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Search of human proteins with 6005924
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6005924 downregulated in renal cell carcinoma [Homo sapiens]
(144 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115583665 downregulated in renal cell carcinoma [Homo sapiens] 290 4e-79
gi|6005924 downregulated in renal cell carcinoma [Homo sapiens] 290 4e-79
gi|40254982 hypothetical protein LOC83641 [Homo sapiens] 138 2e-33
gi|148746195 trichohyalin [Homo sapiens] 40 9e-04
gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens] 38 0.003
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 37 0.006
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 37 0.006
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 37 0.006
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 37 0.006
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 37 0.006
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 37 0.006
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 35 0.017
gi|154354979 myosin X [Homo sapiens] 35 0.017
gi|221219026 pleckstrin homology-like domain, family B, member 1... 35 0.022
gi|221219024 pleckstrin homology-like domain, family B, member 1... 35 0.022
gi|38424073 pleckstrin homology-like domain, family B, member 1 ... 35 0.022
gi|4758472 G protein pathway suppressor 2 [Homo sapiens] 35 0.022
gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens] 34 0.037
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 34 0.037
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 34 0.037
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 34 0.037
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 34 0.037
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 34 0.037
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] 34 0.048
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 34 0.048
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 34 0.048
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 34 0.048
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 34 0.048
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 34 0.048
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 34 0.048
>gi|115583665 downregulated in renal cell carcinoma [Homo sapiens]
Length = 144
Score = 290 bits (741), Expect = 4e-79
Identities = 144/144 (100%), Positives = 144/144 (100%)
Query: 1 MYSEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLG 60
MYSEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLG
Sbjct: 1 MYSEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLG 60
Query: 61 VDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDH 120
VDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDH
Sbjct: 61 VDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDH 120
Query: 121 APEFIKVRENLRRIATLTSEEREL 144
APEFIKVRENLRRIATLTSEEREL
Sbjct: 121 APEFIKVRENLRRIATLTSEEREL 144
>gi|6005924 downregulated in renal cell carcinoma [Homo sapiens]
Length = 144
Score = 290 bits (741), Expect = 4e-79
Identities = 144/144 (100%), Positives = 144/144 (100%)
Query: 1 MYSEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLG 60
MYSEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLG
Sbjct: 1 MYSEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLG 60
Query: 61 VDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDH 120
VDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDH
Sbjct: 61 VDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDH 120
Query: 121 APEFIKVRENLRRIATLTSEEREL 144
APEFIKVRENLRRIATLTSEEREL
Sbjct: 121 APEFIKVRENLRRIATLTSEEREL 144
>gi|40254982 hypothetical protein LOC83641 [Homo sapiens]
Length = 306
Score = 138 bits (347), Expect = 2e-33
Identities = 72/133 (54%), Positives = 101/133 (75%), Gaps = 6/133 (4%)
Query: 15 LMARPEYREW-NPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEH 73
+MA P+Y E NPELI+P+KL+NPVK SR+HQ+LHRELLMN +RGL +KPELQ+V+E
Sbjct: 175 IMAEPDYIEDDNPELIRPQKLINPVKTSRNHQDLHRELLMNQKRGLAPQNKPELQKVMEK 234
Query: 74 RRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEK---EEDHAPEFIKVREN 130
R+R+Q+IK+K+EE + K+ E ELL+RQQ+L QLE +K E+++APEF+KV+ N
Sbjct: 235 RKRDQVIKQKEEEAQKKK--SDLEIELLKRQQKLEQLELEKQKLQEEQENAPEFVKVKGN 292
Query: 131 LRRIATLTSEERE 143
LRR ++ +E
Sbjct: 293 LRRTGQEVAQAQE 305
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 39.7 bits (91), Expect = 9e-04
Identities = 37/139 (26%), Positives = 62/139 (44%), Gaps = 14/139 (10%)
Query: 4 EIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDS 63
E+Q E + L + RE E + ++L + R +E RE R
Sbjct: 270 ELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERRE------ 323
Query: 64 KPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPE 123
+ E + E RR QL ++E+ E + Q EQE RR+Q+L + E+EE+ +
Sbjct: 324 QQERREQQEERREQQL---RREQEERREQQLRREQEEERREQQLRR-----EQEEERREQ 375
Query: 124 FIKVRENLRRIATLTSEER 142
++ + LRR L E++
Sbjct: 376 QLRREQQLRREQQLRREQQ 394
Score = 39.3 bits (90), Expect = 0.001
Identities = 30/125 (24%), Positives = 60/125 (48%), Gaps = 2/125 (1%)
Query: 18 RPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRN 77
R E + L + ++L + R Q+ R R + +L+R E RR
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQ 349
Query: 78 QLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRIATL 137
QL ++++EE ++L+ EQE RR+Q+L + ++ +++ + ++ + LRR L
Sbjct: 350 QLRREQEEERREQQLR--REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 407
Query: 138 TSEER 142
E++
Sbjct: 408 RREQQ 412
Score = 38.9 bits (89), Expect = 0.002
Identities = 37/143 (25%), Positives = 64/143 (44%), Gaps = 7/143 (4%)
Query: 6 QRERADIGGLMARPEYREWNPE---LIKPKKLLNPVKASRSH--QELHRELLMNHRRGLG 60
+RER D + E +EW L K ++ L + R QE +L R+ L
Sbjct: 230 RRERQD--RVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287
Query: 61 VDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDH 120
+ + E Q+ RR QL +K++EE ++ + +QE +Q+ + + E+EE
Sbjct: 288 RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR 347
Query: 121 APEFIKVRENLRRIATLTSEERE 143
+ + +E RR L E+ E
Sbjct: 348 EQQLRREQEEERREQQLRREQEE 370
Score = 38.1 bits (87), Expect = 0.003
Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 8/107 (7%)
Query: 42 RSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQEL- 100
R QE RE + RR + +L+R E RR Q +++++EE E + Q EQ+L
Sbjct: 328 REQQEERREQQL--RREQEERREQQLRREQEEERREQQLRREQEE-ERREQQLRREQQLR 384
Query: 101 ----LRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRIATLTSEERE 143
LRR+Q+L + ++ +++ + ++ + LRR L E+ E
Sbjct: 385 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE 431
Score = 37.4 bits (85), Expect = 0.004
Identities = 39/136 (28%), Positives = 63/136 (46%), Gaps = 9/136 (6%)
Query: 16 MARPEYREWNPELIKPKKLLNPVKASRSHQELHRE---LLMNHRRGLGVDSKPELQR--- 69
+ R E E + ++ ++ L + R Q L RE L RR + + E +R
Sbjct: 519 LKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578
Query: 70 -VLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVR 128
E RR Q +K+++EE +RL+ E E L +++R Q K E EE+ + +K
Sbjct: 579 LKREEERRQQRLKREQEERLEQRLKRE-EVERLEQEERREQRLKREEPEEERRQQLLKSE 637
Query: 129 E-NLRRIATLTSEERE 143
E RR L E++E
Sbjct: 638 EQEERRQQQLRREQQE 653
Score = 37.4 bits (85), Expect = 0.004
Identities = 35/143 (24%), Positives = 65/143 (45%), Gaps = 5/143 (3%)
Query: 4 EIQRERADIGGLMARP-EYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVD 62
++ RE + L R +YRE + ++LL + +R QEL R+ L +
Sbjct: 1032 QLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEE--LQQE 1089
Query: 63 SKPELQRVLEHRRRNQLIK--KKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDH 120
+ L+ E RRR + + +++EEL+ + Q E+ RR+Q L + + E+ +
Sbjct: 1090 EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQE 1149
Query: 121 APEFIKVRENLRRIATLTSEERE 143
+ ++ RR L + RE
Sbjct: 1150 EEQLLREEPEKRRRQELERQYRE 1172
Score = 37.0 bits (84), Expect = 0.006
Identities = 36/138 (26%), Positives = 69/138 (50%), Gaps = 11/138 (7%)
Query: 6 QRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHR-RGLGVDSK 64
++ER + + E R+W +K ++ + R Q+L R+ R R L ++
Sbjct: 439 EQERREQRLKREQEERRDW----LKREEETERHEQERRKQQLKRDQEEERRERWLKLE-- 492
Query: 65 PELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEF 124
E +R + RR Q +++++EE +RL+ E+E R QQRL ++ ++E+ +
Sbjct: 493 -EEERREQQERREQQLRREQEERREQRLKRQEEEE--RLQQRLRSEQQLRREQEERREQL 549
Query: 125 IKVRENLRRIATLTSEER 142
+K RE +R+ E+R
Sbjct: 550 LK-REEEKRLEQERREQR 566
Score = 36.2 bits (82), Expect = 0.010
Identities = 28/117 (23%), Positives = 57/117 (48%), Gaps = 4/117 (3%)
Query: 18 RPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPEL-QRVLEHRRR 76
R E + + ++ ++ L + R Q+L RE + + L + + E ++ E RR
Sbjct: 384 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR 443
Query: 77 NQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRR 133
Q +K+++EE +R E+E R +Q + + ++EE+ ++K+ E RR
Sbjct: 444 EQRLKREQEE---RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERR 497
Score = 33.9 bits (76), Expect = 0.048
Identities = 34/110 (30%), Positives = 50/110 (45%), Gaps = 11/110 (10%)
Query: 42 RSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKR-LQCPFEQEL 100
R Q L RE + L + E++R+ + RR Q +K+++ E E ++ L EQE
Sbjct: 585 RRQQRLKREQEERLEQRL---KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641
Query: 101 LRRQQ-------RLNQLEKPPEKEEDHAPEFIKVRENLRRIATLTSEERE 143
R+QQ R Q K E+EE + E RR L EE+E
Sbjct: 642 RRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691
Score = 33.5 bits (75), Expect = 0.063
Identities = 35/145 (24%), Positives = 64/145 (44%), Gaps = 9/145 (6%)
Query: 4 EIQRERADIGGLMARP-EYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVD 62
E+QRE + + +YRE + ++LL + R QE R+ +R+ +
Sbjct: 912 ELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ----YRKDKKLQ 967
Query: 63 SKPE--LQRVLEHRRRNQLIKK--KKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEE 118
K E L E RRR + KK ++EEL+ + Q E+ RR+Q + + ++ +
Sbjct: 968 QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQ 1027
Query: 119 DHAPEFIKVRENLRRIATLTSEERE 143
+ ++ RR+ + RE
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYRE 1052
Score = 33.1 bits (74), Expect = 0.083
Identities = 33/116 (28%), Positives = 56/116 (48%), Gaps = 15/116 (12%)
Query: 20 EYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPE-------LQRVLE 72
E E + +K +++ + R Q L RE RR + S+ + L+R +
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652
Query: 73 HRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVR 128
RR +L ++++EE +RL+ E+E RR+Q L E+E++ A E IK R
Sbjct: 653 ERREQRLKREEEEERLEQRLKREHEEE--RREQEL------AEEEQEQARERIKSR 700
Score = 32.3 bits (72), Expect = 0.14
Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 8/78 (10%)
Query: 56 RRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPE 115
RR + +KP LQ L R+ QL+++++EEL+ + E+E RRQ++ Q + +
Sbjct: 884 RRRHTLYAKPALQEQL--RKEQQLLQEEEEELQRE------EREKRRRQEQERQYREEEQ 935
Query: 116 KEEDHAPEFIKVRENLRR 133
+++ + RE RR
Sbjct: 936 LQQEEEQLLREEREKRRR 953
Score = 32.0 bits (71), Expect = 0.18
Identities = 27/88 (30%), Positives = 45/88 (51%), Gaps = 8/88 (9%)
Query: 32 KKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPE--LQRVLEHRRRNQLIK--KKKEEL 87
++LL + R QEL R+ +R V + E L+ E RRR +L + +++EEL
Sbjct: 1121 EQLLREEREKRRRQELERQ----YREEEEVQQEEEQLLREEPEKRRRQELERQYREEEEL 1176
Query: 88 EAKRLQCPFEQELLRRQQRLNQLEKPPE 115
+ + Q E++ RRQ+R Q + E
Sbjct: 1177 QQEEEQLLREEQEKRRQERERQYREEEE 1204
Score = 31.6 bits (70), Expect = 0.24
Identities = 27/116 (23%), Positives = 53/116 (45%), Gaps = 4/116 (3%)
Query: 20 EYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQL 79
+YR+ + ++LL R QE RE L + + L+ E RRR +L
Sbjct: 1079 QYRKEEELQQEEEQLLREEPEKRRRQE--RERQCREEEELQQEEEQLLREEREKRRRQEL 1136
Query: 80 IK--KKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRR 133
+ +++EE++ + Q E+ RR+Q L + + E+ + + ++ + RR
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Score = 31.2 bits (69), Expect = 0.31
Identities = 32/117 (27%), Positives = 52/117 (44%), Gaps = 5/117 (4%)
Query: 20 EYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQL 79
+YR+ K ++LL R QE RE L + + L+ E RRR +
Sbjct: 959 QYRKDKKLQQKEEQLLGEEPEKRRRQE--REKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 80 IK--KKKEELEAKRLQCPFEQELLRR-QQRLNQLEKPPEKEEDHAPEFIKVRENLRR 133
+ +KK+EL+ + Q E+ RR Q+R Q + E +++ + RE RR
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRR 1073
Score = 31.2 bits (69), Expect = 0.31
Identities = 18/62 (29%), Positives = 35/62 (56%), Gaps = 3/62 (4%)
Query: 72 EHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENL 131
E RRR + +K +EE ++L E++ LRRQ+R + + + ++ +F++ + L
Sbjct: 1327 EKRRRQETDRKFREE---EQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL 1383
Query: 132 RR 133
RR
Sbjct: 1384 RR 1385
Score = 30.8 bits (68), Expect = 0.41
Identities = 35/140 (25%), Positives = 64/140 (45%), Gaps = 12/140 (8%)
Query: 4 EIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDS 63
+++RE+ + R E E E ++L + R Q+L RE + RR +
Sbjct: 338 QLRREQEERREQQLRREQEEERRE----QQLRREQEEERREQQLRREQQL--RREQQLRR 391
Query: 64 KPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPE 123
+ +L+R + RR QL + E + +R Q ++ LRR+Q + E+ + E++ +
Sbjct: 392 EQQLRREQQLRREQQL----RREQQLRREQQLRREQQLRREQEEERHEQ--KHEQERREQ 445
Query: 124 FIKVRENLRRIATLTSEERE 143
+K + RR EE E
Sbjct: 446 RLKREQEERRDWLKREEETE 465
Score = 29.6 bits (65), Expect = 0.91
Identities = 20/48 (41%), Positives = 30/48 (62%), Gaps = 7/48 (14%)
Query: 75 RRNQLIKKKKEELEAKRLQCPFEQELLRRQQR----LNQLEKPPEKEE 118
RR +L +K +EE ++L+ EQE LRRQ+R L + + PE+EE
Sbjct: 1717 RRQELERKFREE---EQLRQETEQEQLRRQERYRKILEEEQLRPEREE 1761
Score = 27.7 bits (60), Expect = 3.5
Identities = 26/88 (29%), Positives = 41/88 (46%), Gaps = 8/88 (9%)
Query: 39 KASRSHQELHRE--LLMNHRRGLGVDSKPEL-QRVLEHRRRNQLIKKKKEELEAKRLQCP 95
K+ R Q L L R L + + + QR L + ++++ E E K LQ
Sbjct: 776 KSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE-KELQFL 834
Query: 96 FEQELLRRQQRLNQLEKPPEKEEDHAPE 123
E+E L+R++R QL ++EED E
Sbjct: 835 EEEEQLQRRERAQQL----QEEEDGLQE 858
Score = 27.3 bits (59), Expect = 4.5
Identities = 31/124 (25%), Positives = 57/124 (45%), Gaps = 16/124 (12%)
Query: 20 EYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQL 79
+YRE + ++LL R QEL R+ + ELQ+ E QL
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYR----------EEEELQQEEE-----QL 1183
Query: 80 IKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRIATLTS 139
+++++E+ +R + E+E L+RQ+R Q + ++ D ++ +EN R +
Sbjct: 1184 LREEQEKRRQERERQYREEEELQRQKR-KQRYRDEDQRSDLKWQWEPEKENAVRDNKVYC 1242
Query: 140 EERE 143
+ RE
Sbjct: 1243 KGRE 1246
Score = 27.3 bits (59), Expect = 4.5
Identities = 17/68 (25%), Positives = 37/68 (54%), Gaps = 6/68 (8%)
Query: 66 ELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFI 125
E +++L+ R QL ++E + K L+ E++ LRRQ+R + + + ++ +F+
Sbjct: 1465 EEEQLLQEREEQQL---HRQERDRKFLE---EEQQLRRQERDRKFREQELRSQEPERKFL 1518
Query: 126 KVRENLRR 133
+ + L R
Sbjct: 1519 EEEQQLHR 1526
Score = 26.6 bits (57), Expect = 7.7
Identities = 27/129 (20%), Positives = 59/129 (45%), Gaps = 8/129 (6%)
Query: 7 RERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQ--ELHRELLMNHRRGLGVDSK 64
R+R D R E++E + ++L ++ + H+ E E + R L + K
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQL----QSCKGHETEEFPDEEQLRRRELLELRRK 221
Query: 65 PELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEF 124
++ + R R + +++EE E ++ + +E + Q+ Q ++ ++EE+ +
Sbjct: 222 GREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL 281
Query: 125 IKVRENLRR 133
R+ LRR
Sbjct: 282 --ERQELRR 288
Score = 26.6 bits (57), Expect = 7.7
Identities = 17/74 (22%), Positives = 36/74 (48%), Gaps = 3/74 (4%)
Query: 68 QRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKV 127
QR+ + R R +++ E R + EQEL + +++ + E+ + E+H K
Sbjct: 1835 QRLRQERDRQYRAEEQFATQEKSRRE---EQELWQEEEQKRRQERERKLREEHIRRQQKE 1891
Query: 128 RENLRRIATLTSEE 141
+ R++ + S+E
Sbjct: 1892 EQRHRQVGEIKSQE 1905
>gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]
Length = 1317
Score = 38.1 bits (87), Expect = 0.003
Identities = 34/133 (25%), Positives = 70/133 (52%), Gaps = 11/133 (8%)
Query: 14 GLMARPEYREWNPELIKPKKLLNPV----KASRSHQELHRELLMNHRRGLGVDSKPELQR 69
GL + RE +L +KL+ + K+ ++ E ++ + R+ + ++
Sbjct: 595 GLEFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQ 654
Query: 70 VLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRE 129
+RR+ I+ K ++L A++ + FE+E LR QQ + +L+K ++EE F++V+E
Sbjct: 655 EESLKRRSFHIENKLKDLLAEKEK--FEEERLREQQEI-ELQKKRQEEE----TFLRVQE 707
Query: 130 NLRRIATLTSEER 142
L+R+ L + E+
Sbjct: 708 ELQRLKELNNNEK 720
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 37.0 bits (84), Expect = 0.006
Identities = 26/99 (26%), Positives = 51/99 (51%), Gaps = 5/99 (5%)
Query: 25 NPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKK 84
N E +K ++ L + + E H + L++ R+ + K E +RV E +RR + +K +
Sbjct: 365 NSEALKQQQQLQ--QQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQ 422
Query: 85 EELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPE 123
E+ + +RL+ + + LRR++ Q E+ E + E
Sbjct: 423 EKEQQRRLE---DMQALRREEERRQAEREQEYKRKQLEE 458
Score = 26.9 bits (58), Expect = 5.9
Identities = 22/85 (25%), Positives = 44/85 (51%), Gaps = 9/85 (10%)
Query: 42 RSHQELHRELLMNHRRGLGVDSKPELQRVLEHRR--RNQLIKKKK--EELEAKRLQCPFE 97
+ +E + L + ++ L+R E R+ R Q K+K+ E+ +++RLQ +
Sbjct: 411 QQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQ 470
Query: 98 QE-----LLRRQQRLNQLEKPPEKE 117
QE L++QQ+ QL+K +++
Sbjct: 471 QEHAYLKSLQQQQQQQQLQKQQQQQ 495
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 37.0 bits (84), Expect = 0.006
Identities = 26/99 (26%), Positives = 51/99 (51%), Gaps = 5/99 (5%)
Query: 25 NPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKK 84
N E +K ++ L + + E H + L++ R+ + K E +RV E +RR + +K +
Sbjct: 365 NSEALKQQQQLQ--QQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQ 422
Query: 85 EELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPE 123
E+ + +RL+ + + LRR++ Q E+ E + E
Sbjct: 423 EKEQQRRLE---DMQALRREEERRQAEREQEYKRKQLEE 458
Score = 26.9 bits (58), Expect = 5.9
Identities = 22/85 (25%), Positives = 44/85 (51%), Gaps = 9/85 (10%)
Query: 42 RSHQELHRELLMNHRRGLGVDSKPELQRVLEHRR--RNQLIKKKK--EELEAKRLQCPFE 97
+ +E + L + ++ L+R E R+ R Q K+K+ E+ +++RLQ +
Sbjct: 411 QQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQ 470
Query: 98 QE-----LLRRQQRLNQLEKPPEKE 117
QE L++QQ+ QL+K +++
Sbjct: 471 QEHAYLKSLQQQQQQQQLQKQQQQQ 495
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 37.0 bits (84), Expect = 0.006
Identities = 26/99 (26%), Positives = 51/99 (51%), Gaps = 5/99 (5%)
Query: 25 NPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKK 84
N E +K ++ L + + E H + L++ R+ + K E +RV E +RR + +K +
Sbjct: 365 NSEALKQQQQLQ--QQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQ 422
Query: 85 EELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPE 123
E+ + +RL+ + + LRR++ Q E+ E + E
Sbjct: 423 EKEQQRRLE---DMQALRREEERRQAEREQEYKRKQLEE 458
Score = 26.9 bits (58), Expect = 5.9
Identities = 22/85 (25%), Positives = 44/85 (51%), Gaps = 9/85 (10%)
Query: 42 RSHQELHRELLMNHRRGLGVDSKPELQRVLEHRR--RNQLIKKKK--EELEAKRLQCPFE 97
+ +E + L + ++ L+R E R+ R Q K+K+ E+ +++RLQ +
Sbjct: 411 QQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQ 470
Query: 98 QE-----LLRRQQRLNQLEKPPEKE 117
QE L++QQ+ QL+K +++
Sbjct: 471 QEHAYLKSLQQQQQQQQLQKQQQQQ 495
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 37.0 bits (84), Expect = 0.006
Identities = 26/99 (26%), Positives = 51/99 (51%), Gaps = 5/99 (5%)
Query: 25 NPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKK 84
N E +K ++ L + + E H + L++ R+ + K E +RV E +RR + +K +
Sbjct: 365 NSEALKQQQQLQ--QQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQ 422
Query: 85 EELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPE 123
E+ + +RL+ + + LRR++ Q E+ E + E
Sbjct: 423 EKEQQRRLE---DMQALRREEERRQAEREQEYKRKQLEE 458
Score = 26.9 bits (58), Expect = 5.9
Identities = 22/85 (25%), Positives = 44/85 (51%), Gaps = 9/85 (10%)
Query: 42 RSHQELHRELLMNHRRGLGVDSKPELQRVLEHRR--RNQLIKKKK--EELEAKRLQCPFE 97
+ +E + L + ++ L+R E R+ R Q K+K+ E+ +++RLQ +
Sbjct: 411 QQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQ 470
Query: 98 QE-----LLRRQQRLNQLEKPPEKE 117
QE L++QQ+ QL+K +++
Sbjct: 471 QEHAYLKSLQQQQQQQQLQKQQQQQ 495
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 37.0 bits (84), Expect = 0.006
Identities = 39/122 (31%), Positives = 51/122 (41%), Gaps = 24/122 (19%)
Query: 33 KLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEE------ 86
K + V+A R +E R L LQ+ E RR +L++KKKEE
Sbjct: 630 KKMEEVEARRKQEEEARRLRW-------------LQQEEEERRHQELLQKKKEEEQERLR 676
Query: 87 --LEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIK--VRENLRRIATLTSEER 142
EAKRL EQE R Q+R Q + E+ E E + + RR ER
Sbjct: 677 KAAEAKRLAEQREQE-RREQERREQERREQERREQERREQERQLAEQERRREQERLQAER 735
Query: 143 EL 144
EL
Sbjct: 736 EL 737
Score = 32.0 bits (71), Expect = 0.18
Identities = 27/91 (29%), Positives = 42/91 (46%), Gaps = 12/91 (13%)
Query: 64 KPELQRVLEHRRRNQLIKKKKEEL--------EAKRLQCPFEQELLRRQQRLNQLEKPPE 115
K + +R+ E + + + KK EE+ EA+RL+ ++E RR Q L Q +K E
Sbjct: 612 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEE 671
Query: 116 KEE----DHAPEFIKVRENLRRIATLTSEER 142
+E A + RE RR +ER
Sbjct: 672 QERLRKAAEAKRLAEQREQERREQERREQER 702
Score = 31.6 bits (70), Expect = 0.24
Identities = 29/119 (24%), Positives = 55/119 (46%), Gaps = 4/119 (3%)
Query: 16 MARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRR 75
M E R E + + L + R HQEL ++ + L E +R+ E R
Sbjct: 632 MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLR--KAAEAKRLAEQRE 689
Query: 76 RNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRI 134
+ + ++++E+ +R Q EQE ++++L + E+ E+E A ++ RE R+
Sbjct: 690 QERREQERREQ--ERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRL 746
Score = 27.3 bits (59), Expect = 4.5
Identities = 27/109 (24%), Positives = 49/109 (44%), Gaps = 8/109 (7%)
Query: 43 SHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLR 102
S E R+ L N RR + + + RRR + +K K+EE K LQ E ++
Sbjct: 533 SFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK 592
Query: 103 R------QQRLNQLEKPPE--KEEDHAPEFIKVRENLRRIATLTSEERE 143
+Q+ Q+++ E KEE A E K + +++ + + ++
Sbjct: 593 EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ 641
Score = 26.9 bits (58), Expect = 5.9
Identities = 27/102 (26%), Positives = 45/102 (44%), Gaps = 7/102 (6%)
Query: 18 RPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRN 77
+ E +E + + K+L + R QE + R + E Q + RRR
Sbjct: 668 KEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRRE 727
Query: 78 QLIKKKKEELEAKRLQCPFEQEL-LRRQQRLNQLEKPPEKEE 118
Q E L+A+R E+ L L+++Q +LE+ +KEE
Sbjct: 728 Q------ERLQAERELQEREKALRLQKEQLQRELEEKKKKEE 763
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 37.0 bits (84), Expect = 0.006
Identities = 39/122 (31%), Positives = 51/122 (41%), Gaps = 24/122 (19%)
Query: 33 KLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEE------ 86
K + V+A R +E R L LQ+ E RR +L++KKKEE
Sbjct: 626 KKMEEVEARRKQEEEARRLRW-------------LQQEEEERRHQELLQKKKEEEQERLR 672
Query: 87 --LEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIK--VRENLRRIATLTSEER 142
EAKRL EQE R Q+R Q + E+ E E + + RR ER
Sbjct: 673 KAAEAKRLAEQREQE-RREQERREQERREQERREQERREQERQLAEQERRREQERLQAER 731
Query: 143 EL 144
EL
Sbjct: 732 EL 733
Score = 32.0 bits (71), Expect = 0.18
Identities = 27/91 (29%), Positives = 42/91 (46%), Gaps = 12/91 (13%)
Query: 64 KPELQRVLEHRRRNQLIKKKKEEL--------EAKRLQCPFEQELLRRQQRLNQLEKPPE 115
K + +R+ E + + + KK EE+ EA+RL+ ++E RR Q L Q +K E
Sbjct: 608 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEE 667
Query: 116 KEE----DHAPEFIKVRENLRRIATLTSEER 142
+E A + RE RR +ER
Sbjct: 668 QERLRKAAEAKRLAEQREQERREQERREQER 698
Score = 31.6 bits (70), Expect = 0.24
Identities = 29/119 (24%), Positives = 55/119 (46%), Gaps = 4/119 (3%)
Query: 16 MARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRR 75
M E R E + + L + R HQEL ++ + L E +R+ E R
Sbjct: 628 MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLR--KAAEAKRLAEQRE 685
Query: 76 RNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRI 134
+ + ++++E+ +R Q EQE ++++L + E+ E+E A ++ RE R+
Sbjct: 686 QERREQERREQ--ERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRL 742
Score = 30.8 bits (68), Expect = 0.41
Identities = 31/115 (26%), Positives = 56/115 (48%), Gaps = 13/115 (11%)
Query: 34 LLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRN----QLIKKKKEELEA 89
L+ P A RS + + L +D K + ++ LE+ RR QL ++K EE +
Sbjct: 505 LMTPTSAPRSVMKS----FIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKR 560
Query: 90 KRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIK-VRENLRRIATLTSEERE 143
+RL E+ L+R++RL ++ + E+ E E K + + +I T + +E
Sbjct: 561 RRL----EEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 611
Score = 26.9 bits (58), Expect = 5.9
Identities = 27/102 (26%), Positives = 45/102 (44%), Gaps = 7/102 (6%)
Query: 18 RPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRN 77
+ E +E + + K+L + R QE + R + E Q + RRR
Sbjct: 664 KEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRRE 723
Query: 78 QLIKKKKEELEAKRLQCPFEQEL-LRRQQRLNQLEKPPEKEE 118
Q E L+A+R E+ L L+++Q +LE+ +KEE
Sbjct: 724 Q------ERLQAERELQEREKALRLQKEQLQRELEEKKKKEE 759
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 35.4 bits (80), Expect = 0.017
Identities = 34/93 (36%), Positives = 45/93 (48%), Gaps = 17/93 (18%)
Query: 45 QELHRELLMN---HRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELL 101
QEL L+ HR + +K ELQ H+R Q I KK+ + E E L
Sbjct: 564 QELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDT-------ELENL 616
Query: 102 RRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRI 134
RQQ+ Q+EK E+DHA ++ RE RRI
Sbjct: 617 ERQQK-QQVEK---MEQDHA---VRRREEARRI 642
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 35.4 bits (80), Expect = 0.017
Identities = 30/132 (22%), Positives = 64/132 (48%), Gaps = 4/132 (3%)
Query: 9 RADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQ 68
RA + G +AR +YR+ ++ +K R L + ++ ++ G ++ +
Sbjct: 750 RAHVLGFLARKQYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAIVFQKQLRGQIARRVYR 809
Query: 69 RVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVR 128
++L +R + KK++EE + KR + E+E RR+ L + ++EE + ++
Sbjct: 810 QLLAEKREQEEKKKQEEEEKKKREEEERERERERREAEL----RAQQEEETRKQQELEAL 865
Query: 129 ENLRRIATLTSE 140
+ ++ A LT E
Sbjct: 866 QKSQKEAELTRE 877
>gi|221219026 pleckstrin homology-like domain, family B, member 1
isoform b [Homo sapiens]
Length = 1319
Score = 35.0 bits (79), Expect = 0.022
Identities = 20/79 (25%), Positives = 44/79 (55%), Gaps = 4/79 (5%)
Query: 53 MNHRRGLGVDSKPELQRVLE--HRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQL 110
M+ GL + E++++L+ H +N+L++ ++ E+E +R E+E RR+Q +L
Sbjct: 1090 MSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQA--LEEERRRREQVERRL 1147
Query: 111 EKPPEKEEDHAPEFIKVRE 129
+ + + + +K+RE
Sbjct: 1148 QSESARRQQLVEKEVKMRE 1166
>gi|221219024 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 35.0 bits (79), Expect = 0.022
Identities = 20/79 (25%), Positives = 44/79 (55%), Gaps = 4/79 (5%)
Query: 53 MNHRRGLGVDSKPELQRVLE--HRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQL 110
M+ GL + E++++L+ H +N+L++ ++ E+E +R E+E RR+Q +L
Sbjct: 1137 MSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQA--LEEERRRREQVERRL 1194
Query: 111 EKPPEKEEDHAPEFIKVRE 129
+ + + + +K+RE
Sbjct: 1195 QSESARRQQLVEKEVKMRE 1213
>gi|38424073 pleckstrin homology-like domain, family B, member 1
isoform a [Homo sapiens]
Length = 1377
Score = 35.0 bits (79), Expect = 0.022
Identities = 20/79 (25%), Positives = 44/79 (55%), Gaps = 4/79 (5%)
Query: 53 MNHRRGLGVDSKPELQRVLE--HRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQL 110
M+ GL + E++++L+ H +N+L++ ++ E+E +R E+E RR+Q +L
Sbjct: 1137 MSSASGLDMGKIEEMEKMLKEAHAEKNRLMESREREMELRRQA--LEEERRRREQVERRL 1194
Query: 111 EKPPEKEEDHAPEFIKVRE 129
+ + + + +K+RE
Sbjct: 1195 QSESARRQQLVEKEVKMRE 1213
>gi|4758472 G protein pathway suppressor 2 [Homo sapiens]
Length = 327
Score = 35.0 bits (79), Expect = 0.022
Identities = 24/114 (21%), Positives = 56/114 (49%), Gaps = 7/114 (6%)
Query: 31 PKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAK 90
P L P ++ + LHR ++M R + E+ +++E + + + ++KK+E+E +
Sbjct: 2 PALLERPKLSNAMARALHRHIMMERERKR--QEEEEVDKMMEQKMKEEQERRKKKEMEER 59
Query: 91 RLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRR-----IATLTS 139
++++L+ +++L L++ + + + E RR + TLTS
Sbjct: 60 MSLEETKEQILKLEEKLLALQEEKHQLFLQLKKVLHEEEKRRRKEQSDLTTLTS 113
>gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens]
Length = 412
Score = 34.3 bits (77), Expect = 0.037
Identities = 28/102 (27%), Positives = 49/102 (48%), Gaps = 13/102 (12%)
Query: 30 KPKKLLNPVKASRS-HQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELE 88
+P++ L V+ + H++L RELL H R + R L+ N L++K K+
Sbjct: 75 EPRQNLKCVRILKQFHKDLERELLRRHHRS-------KTPRHLDPSLANYLVQKAKQRRA 127
Query: 89 AKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPE-FIKVRE 129
+R +EQEL ++ L ++ E + D P F+ + E
Sbjct: 128 LRR----WEQELNAKRSHLGRITVENEVDLDGPPRAFVYINE 165
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 34.3 bits (77), Expect = 0.037
Identities = 24/74 (32%), Positives = 39/74 (52%), Gaps = 5/74 (6%)
Query: 42 RSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELL 101
R QE R+L + + ++ + EL+R E RR ++ +++ + E +R Q E E
Sbjct: 398 RQEQERKRQLELEKQ----LEKQRELERQREEERRKEIERREAAKRELER-QRQLEWERN 452
Query: 102 RRQQRLNQLEKPPE 115
RRQ+ LNQ K E
Sbjct: 453 RRQELLNQRNKEQE 466
Score = 32.3 bits (72), Expect = 0.14
Identities = 32/118 (27%), Positives = 50/118 (42%), Gaps = 12/118 (10%)
Query: 28 LIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEEL 87
LI K++LN LHR+ L+ +R L E + + R+QL + +KE
Sbjct: 541 LIPEKQILNDQLKQVQQNSLHRDSLVTLKRAL------EAKELARQHLRDQLDEVEKETR 594
Query: 88 EAKRLQCPFEQEL--LRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRIATLTSEERE 143
+ F +L LR QL+K E E +K +E R+I L ++ E
Sbjct: 595 SKLQEIDIFNNQLKELREIHNKQQLQKQKSME----AERLKQKEQERKIIELEKQKEE 648
Score = 28.1 bits (61), Expect = 2.7
Identities = 27/91 (29%), Positives = 43/91 (47%), Gaps = 4/91 (4%)
Query: 54 NHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLN-QLEK 112
N RG ++ + Q +LE +R+ Q + E E +R + +++ +RQ L QLEK
Sbjct: 357 NFERG-NLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEK 415
Query: 113 PPEKEEDHAPEFIKVRENLRRIATLTSEERE 143
E E E + +E RR A ER+
Sbjct: 416 QRELERQREEE--RRKEIERREAAKRELERQ 444
Score = 28.1 bits (61), Expect = 2.7
Identities = 20/84 (23%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
Query: 61 VDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQ-LEKPPEKEED 119
+ +K +LQ+ + + +K+K++E + L+ E+ R Q+R Q LE +++E
Sbjct: 613 IHNKQQLQK--QKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEH 670
Query: 120 HAPEFIKVRENLRRIATLTSEERE 143
P + E L+R ++ ++ E
Sbjct: 671 QRPRKLHEEEKLKREESVKKKDGE 694
Score = 27.3 bits (59), Expect = 4.5
Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 5/78 (6%)
Query: 71 LEHRRRNQLIKKKKEELEAKRLQCPFEQELLRR----QQRLNQLEKPPEKEEDHAPEFIK 126
LE RR+ L +++KE+ +L+ EQE R Q+R QLE + E+ E +
Sbjct: 365 LEKRRQALLEQQRKEQERLAQLERA-EQERKERERQEQERKRQLELEKQLEKQRELERQR 423
Query: 127 VRENLRRIATLTSEEREL 144
E + I + +REL
Sbjct: 424 EEERRKEIERREAAKREL 441
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 34.3 bits (77), Expect = 0.037
Identities = 24/74 (32%), Positives = 39/74 (52%), Gaps = 5/74 (6%)
Query: 42 RSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELL 101
R QE R+L + + ++ + EL+R E RR ++ +++ + E +R Q E E
Sbjct: 398 RQEQERKRQLELEKQ----LEKQRELERQREEERRKEIERREAAKRELER-QRQLEWERN 452
Query: 102 RRQQRLNQLEKPPE 115
RRQ+ LNQ K E
Sbjct: 453 RRQELLNQRNKEQE 466
Score = 32.3 bits (72), Expect = 0.14
Identities = 32/118 (27%), Positives = 50/118 (42%), Gaps = 12/118 (10%)
Query: 28 LIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEEL 87
LI K++LN LHR+ L+ +R L E + + R+QL + +KE
Sbjct: 541 LIPEKQILNDQLKQVQQNSLHRDSLVTLKRAL------EAKELARQHLRDQLDEVEKETR 594
Query: 88 EAKRLQCPFEQEL--LRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRIATLTSEERE 143
+ F +L LR QL+K E E +K +E R+I L ++ E
Sbjct: 595 SKLQEIDIFNNQLKELREIHNKQQLQKQKSME----AERLKQKEQERKIIELEKQKEE 648
Score = 28.1 bits (61), Expect = 2.7
Identities = 27/91 (29%), Positives = 43/91 (47%), Gaps = 4/91 (4%)
Query: 54 NHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLN-QLEK 112
N RG ++ + Q +LE +R+ Q + E E +R + +++ +RQ L QLEK
Sbjct: 357 NFERG-NLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEK 415
Query: 113 PPEKEEDHAPEFIKVRENLRRIATLTSEERE 143
E E E + +E RR A ER+
Sbjct: 416 QRELERQREEE--RRKEIERREAAKRELERQ 444
Score = 28.1 bits (61), Expect = 2.7
Identities = 20/84 (23%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
Query: 61 VDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQ-LEKPPEKEED 119
+ +K +LQ+ + + +K+K++E + L+ E+ R Q+R Q LE +++E
Sbjct: 613 IHNKQQLQK--QKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEH 670
Query: 120 HAPEFIKVRENLRRIATLTSEERE 143
P + E L+R ++ ++ E
Sbjct: 671 QRPRKLHEEEKLKREESVKKKDGE 694
Score = 27.3 bits (59), Expect = 4.5
Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 5/78 (6%)
Query: 71 LEHRRRNQLIKKKKEELEAKRLQCPFEQELLRR----QQRLNQLEKPPEKEEDHAPEFIK 126
LE RR+ L +++KE+ +L+ EQE R Q+R QLE + E+ E +
Sbjct: 365 LEKRRQALLEQQRKEQERLAQLERA-EQERKERERQEQERKRQLELEKQLEKQRELERQR 423
Query: 127 VRENLRRIATLTSEEREL 144
E + I + +REL
Sbjct: 424 EEERRKEIERREAAKREL 441
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 34.3 bits (77), Expect = 0.037
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 9/99 (9%)
Query: 20 EYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQL 79
+ RE + K K+ + QE ++L + R ++ + EL+R E RR +
Sbjct: 389 QQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKR----LEKQRELERQREEERRKDI 444
Query: 80 IKKK--KEELEAKRLQCPFEQELLRRQQRLNQLEKPPEK 116
+++ K+ELE +R E E +RRQ+ LNQ + E+
Sbjct: 445 ERREAAKQELERQRR---LEWERIRRQELLNQKNREQEE 480
Score = 29.6 bits (65), Expect = 0.91
Identities = 31/117 (26%), Positives = 55/117 (47%), Gaps = 19/117 (16%)
Query: 35 LNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQC 94
L ++ + + Q+L E L +R D E++R +R +L++KKK E EA R
Sbjct: 620 LKELRETYNTQQLALEQLYKIKR----DKLKEIER-----KRLELMQKKKLEDEAARKAK 670
Query: 95 PFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRIA--------TLTSEERE 143
++ L + R + EK +E+ E K++E R+ TL +EE++
Sbjct: 671 QGKENLWKENLRKEEEEKQKRLQEEKTQE--KIQEEERKAEEKQRKDKDTLKAEEKK 725
Score = 27.7 bits (60), Expect = 3.5
Identities = 32/136 (23%), Positives = 61/136 (44%), Gaps = 5/136 (3%)
Query: 13 GGLMARPEYREWNPELIKPKKLLNPVKAS--RSHQELH--RELLMNHRRGLGVDSKPELQ 68
G L + + +E P+ P + KA+ R + EL R+ LM ++ + +
Sbjct: 342 GTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEK 401
Query: 69 RVLEHRRRNQLIKKKKEELEA-KRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKV 127
E ++R ++ K++LE KRL+ E E R ++R +E+ +++ +
Sbjct: 402 EEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE 461
Query: 128 RENLRRIATLTSEERE 143
E +RR L + RE
Sbjct: 462 WERIRRQELLNQKNRE 477
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 34.3 bits (77), Expect = 0.037
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 9/99 (9%)
Query: 20 EYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQL 79
+ RE + K K+ + QE ++L + R ++ + EL+R E RR +
Sbjct: 389 QQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKR----LEKQRELERQREEERRKDI 444
Query: 80 IKKK--KEELEAKRLQCPFEQELLRRQQRLNQLEKPPEK 116
+++ K+ELE +R E E +RRQ+ LNQ + E+
Sbjct: 445 ERREAAKQELERQRR---LEWERIRRQELLNQKNREQEE 480
Score = 31.2 bits (69), Expect = 0.31
Identities = 32/118 (27%), Positives = 56/118 (47%), Gaps = 19/118 (16%)
Query: 34 LLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQ 93
LL ++ + + Q+L E L +R D E++R +R +L++KKK E EA R
Sbjct: 646 LLKELRETYNTQQLALEQLYKIKR----DKLKEIER-----KRLELMQKKKLEDEAARKA 696
Query: 94 CPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRIA--------TLTSEERE 143
++ L + R + EK +E+ E K++E R+ TL +EE++
Sbjct: 697 KQGKENLWKENLRKEEEEKQKRLQEEKTQE--KIQEEERKAEEKQRKDKDTLKAEEKK 752
Score = 27.7 bits (60), Expect = 3.5
Identities = 32/136 (23%), Positives = 61/136 (44%), Gaps = 5/136 (3%)
Query: 13 GGLMARPEYREWNPELIKPKKLLNPVKAS--RSHQELH--RELLMNHRRGLGVDSKPELQ 68
G L + + +E P+ P + KA+ R + EL R+ LM ++ + +
Sbjct: 342 GTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEK 401
Query: 69 RVLEHRRRNQLIKKKKEELEA-KRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKV 127
E ++R ++ K++LE KRL+ E E R ++R +E+ +++ +
Sbjct: 402 EEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE 461
Query: 128 RENLRRIATLTSEERE 143
E +RR L + RE
Sbjct: 462 WERIRRQELLNQKNRE 477
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 34.3 bits (77), Expect = 0.037
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 9/99 (9%)
Query: 20 EYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQL 79
+ RE + K K+ + QE ++L + R ++ + EL+R E RR +
Sbjct: 389 QQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKR----LEKQRELERQREEERRKDI 444
Query: 80 IKKK--KEELEAKRLQCPFEQELLRRQQRLNQLEKPPEK 116
+++ K+ELE +R E E +RRQ+ LNQ + E+
Sbjct: 445 ERREAAKQELERQRR---LEWERIRRQELLNQKNREQEE 480
Score = 31.2 bits (69), Expect = 0.31
Identities = 32/118 (27%), Positives = 56/118 (47%), Gaps = 19/118 (16%)
Query: 34 LLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQ 93
LL ++ + + Q+L E L +R D E++R +R +L++KKK E EA R
Sbjct: 646 LLKELRETYNTQQLALEQLYKIKR----DKLKEIER-----KRLELMQKKKLEDEAARKA 696
Query: 94 CPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRIA--------TLTSEERE 143
++ L + R + EK +E+ E K++E R+ TL +EE++
Sbjct: 697 KQGKENLWKENLRKEEEEKQKRLQEEKTQE--KIQEEERKAEEKQRKDKDTLKAEEKK 752
Score = 27.7 bits (60), Expect = 3.5
Identities = 32/136 (23%), Positives = 61/136 (44%), Gaps = 5/136 (3%)
Query: 13 GGLMARPEYREWNPELIKPKKLLNPVKAS--RSHQELH--RELLMNHRRGLGVDSKPELQ 68
G L + + +E P+ P + KA+ R + EL R+ LM ++ + +
Sbjct: 342 GTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEK 401
Query: 69 RVLEHRRRNQLIKKKKEELEA-KRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKV 127
E ++R ++ K++LE KRL+ E E R ++R +E+ +++ +
Sbjct: 402 EEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE 461
Query: 128 RENLRRIATLTSEERE 143
E +RR L + RE
Sbjct: 462 WERIRRQELLNQKNRE 477
>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
Length = 202
Score = 33.9 bits (76), Expect = 0.048
Identities = 23/89 (25%), Positives = 41/89 (46%)
Query: 45 QELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQ 104
+E R N + G D + E +R E R+ Q ++++ + E KR Q R+
Sbjct: 106 RETDRNRERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAERE 165
Query: 105 QRLNQLEKPPEKEEDHAPEFIKVRENLRR 133
+R + +K +KE + K RE+ +R
Sbjct: 166 ERKKERKKERKKERKEKKKEEKRREDKKR 194
Score = 26.6 bits (57), Expect = 7.7
Identities = 24/100 (24%), Positives = 45/100 (45%), Gaps = 6/100 (6%)
Query: 46 ELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQ 105
E RE RG + + + QR E++ + ++++ + Q E+E R+++
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61
Query: 106 R--LNQLEKPPEKEEDHAPEFIKVRENLRRIATLTSEERE 143
R Q E+ E+E + E + RE R+ T ER+
Sbjct: 62 RDRQRQRERETERETERQRERQRQRERKRQ----TDRERD 97
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 33.9 bits (76), Expect = 0.048
Identities = 36/163 (22%), Positives = 79/163 (48%), Gaps = 25/163 (15%)
Query: 3 SEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVD 62
+E++RE+ + + + + ++ ++LL +A + ++ L+ R + +
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2512
Query: 63 SKPELQRVL------------EHRRRNQLIKKKKEEL-----EAKRLQCPFEQELLRRQQ 105
K +L+++ E +R+ Q ++++++ L EA+R Q E+ + R+Q+
Sbjct: 2513 -KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2571
Query: 106 RLNQLEKPPEKEED-HAPEFIKVRENLR------RIATLTSEE 141
L QLE+ ++E+ A E ++RE L+ R A SEE
Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Score = 30.0 bits (66), Expect = 0.70
Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 3/84 (3%)
Query: 64 KPELQRVLEHRRRNQ---LIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDH 120
K EL+ L R N L K++ ELEA R + +E RR++ +++K EE+
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2000
Query: 121 APEFIKVRENLRRIATLTSEEREL 144
A + E + R+ E R L
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRL 2024
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 33.9 bits (76), Expect = 0.048
Identities = 36/163 (22%), Positives = 79/163 (48%), Gaps = 25/163 (15%)
Query: 3 SEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVD 62
+E++RE+ + + + + ++ ++LL +A + ++ L+ R + +
Sbjct: 2457 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2516
Query: 63 SKPELQRVL------------EHRRRNQLIKKKKEEL-----EAKRLQCPFEQELLRRQQ 105
K +L+++ E +R+ Q ++++++ L EA+R Q E+ + R+Q+
Sbjct: 2517 -KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2575
Query: 106 RLNQLEKPPEKEED-HAPEFIKVRENLR------RIATLTSEE 141
L QLE+ ++E+ A E ++RE L+ R A SEE
Sbjct: 2576 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2618
Score = 30.0 bits (66), Expect = 0.70
Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 3/84 (3%)
Query: 64 KPELQRVLEHRRRNQ---LIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDH 120
K EL+ L R N L K++ ELEA R + +E RR++ +++K EE+
Sbjct: 1945 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2004
Query: 121 APEFIKVRENLRRIATLTSEEREL 144
A + E + R+ E R L
Sbjct: 2005 ARQRKAALEEVERLKAKVEEARRL 2028
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 33.9 bits (76), Expect = 0.048
Identities = 36/163 (22%), Positives = 79/163 (48%), Gaps = 25/163 (15%)
Query: 3 SEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVD 62
+E++RE+ + + + + ++ ++LL +A + ++ L+ R + +
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2512
Query: 63 SKPELQRVL------------EHRRRNQLIKKKKEEL-----EAKRLQCPFEQELLRRQQ 105
K +L+++ E +R+ Q ++++++ L EA+R Q E+ + R+Q+
Sbjct: 2513 -KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2571
Query: 106 RLNQLEKPPEKEED-HAPEFIKVRENLR------RIATLTSEE 141
L QLE+ ++E+ A E ++RE L+ R A SEE
Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Score = 30.0 bits (66), Expect = 0.70
Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 3/84 (3%)
Query: 64 KPELQRVLEHRRRNQ---LIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDH 120
K EL+ L R N L K++ ELEA R + +E RR++ +++K EE+
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2000
Query: 121 APEFIKVRENLRRIATLTSEEREL 144
A + E + R+ E R L
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRL 2024
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 33.9 bits (76), Expect = 0.048
Identities = 36/163 (22%), Positives = 79/163 (48%), Gaps = 25/163 (15%)
Query: 3 SEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVD 62
+E++RE+ + + + + ++ ++LL +A + ++ L+ R + +
Sbjct: 2421 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2480
Query: 63 SKPELQRVL------------EHRRRNQLIKKKKEEL-----EAKRLQCPFEQELLRRQQ 105
K +L+++ E +R+ Q ++++++ L EA+R Q E+ + R+Q+
Sbjct: 2481 -KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2539
Query: 106 RLNQLEKPPEKEED-HAPEFIKVRENLR------RIATLTSEE 141
L QLE+ ++E+ A E ++RE L+ R A SEE
Sbjct: 2540 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2582
Score = 30.0 bits (66), Expect = 0.70
Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 3/84 (3%)
Query: 64 KPELQRVLEHRRRNQ---LIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDH 120
K EL+ L R N L K++ ELEA R + +E RR++ +++K EE+
Sbjct: 1909 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 1968
Query: 121 APEFIKVRENLRRIATLTSEEREL 144
A + E + R+ E R L
Sbjct: 1969 ARQRKAALEEVERLKAKVEEARRL 1992
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 33.9 bits (76), Expect = 0.048
Identities = 36/163 (22%), Positives = 79/163 (48%), Gaps = 25/163 (15%)
Query: 3 SEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVD 62
+E++RE+ + + + + ++ ++LL +A + ++ L+ R + +
Sbjct: 2590 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2649
Query: 63 SKPELQRVL------------EHRRRNQLIKKKKEEL-----EAKRLQCPFEQELLRRQQ 105
K +L+++ E +R+ Q ++++++ L EA+R Q E+ + R+Q+
Sbjct: 2650 -KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2708
Query: 106 RLNQLEKPPEKEED-HAPEFIKVRENLR------RIATLTSEE 141
L QLE+ ++E+ A E ++RE L+ R A SEE
Sbjct: 2709 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2751
Score = 30.0 bits (66), Expect = 0.70
Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 3/84 (3%)
Query: 64 KPELQRVLEHRRRNQ---LIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDH 120
K EL+ L R N L K++ ELEA R + +E RR++ +++K EE+
Sbjct: 2078 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2137
Query: 121 APEFIKVRENLRRIATLTSEEREL 144
A + E + R+ E R L
Sbjct: 2138 ARQRKAALEEVERLKAKVEEARRL 2161
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 33.9 bits (76), Expect = 0.048
Identities = 36/163 (22%), Positives = 79/163 (48%), Gaps = 25/163 (15%)
Query: 3 SEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVD 62
+E++RE+ + + + + ++ ++LL +A + ++ L+ R + +
Sbjct: 2431 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2490
Query: 63 SKPELQRVL------------EHRRRNQLIKKKKEEL-----EAKRLQCPFEQELLRRQQ 105
K +L+++ E +R+ Q ++++++ L EA+R Q E+ + R+Q+
Sbjct: 2491 -KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2549
Query: 106 RLNQLEKPPEKEED-HAPEFIKVRENLR------RIATLTSEE 141
L QLE+ ++E+ A E ++RE L+ R A SEE
Sbjct: 2550 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2592
Score = 30.0 bits (66), Expect = 0.70
Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 3/84 (3%)
Query: 64 KPELQRVLEHRRRNQ---LIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDH 120
K EL+ L R N L K++ ELEA R + +E RR++ +++K EE+
Sbjct: 1919 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 1978
Query: 121 APEFIKVRENLRRIATLTSEEREL 144
A + E + R+ E R L
Sbjct: 1979 ARQRKAALEEVERLKAKVEEARRL 2002
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,966,419
Number of Sequences: 37866
Number of extensions: 286296
Number of successful extensions: 3007
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 100
Number of HSP's successfully gapped in prelim test: 275
Number of HSP's that attempted gapping in prelim test: 2101
Number of HSP's gapped (non-prelim): 937
length of query: 144
length of database: 18,247,518
effective HSP length: 92
effective length of query: 52
effective length of database: 14,763,846
effective search space: 767719992
effective search space used: 767719992
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 57 (26.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.