Search of human proteins with 58743365

Search of human proteins with 58743365

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|58743365 ring finger protein 157 [Homo sapiens]
         (679 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|58743365 ring finger protein 157 [Homo sapiens]                   1375   0.0  
gi|214010238 mahogunin, ring finger 1 isoform 4 [Homo sapiens]        571   e-163
gi|214010234 mahogunin, ring finger 1 isoform 2 [Homo sapiens]        571   e-163
gi|214010236 mahogunin, ring finger 1 isoform 3 [Homo sapiens]        559   e-159
gi|44917608 mahogunin, ring finger 1 isoform 1 [Homo sapiens]         559   e-159
gi|217416388 neuralized homolog 1B [Homo sapiens]                      54   6e-07
gi|14042925 ring finger protein 26 [Homo sapiens]                      52   1e-06
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]          50   5e-06
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]          50   5e-06
gi|91982772 mucin 17 [Homo sapiens]                                    50   7e-06
gi|5729765 cell growth regulator with ring finger domain 1 [Homo...    49   1e-05
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    48   3e-05
gi|223278368 neuralized-like [Homo sapiens]                            47   4e-05
gi|53729363 leucine rich repeat and sterile alpha motif containi...    45   2e-04
gi|53729361 leucine rich repeat and sterile alpha motif containi...    45   2e-04
gi|53729359 leucine rich repeat and sterile alpha motif containi...    45   2e-04
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]         45   2e-04
gi|171542821 mitochondrial ubiquitin ligase activator of NFKB 1 ...    45   3e-04
gi|57165361 ring finger protein 165 [Homo sapiens]                     43   8e-04
gi|21361493 ring finger protein 141 [Homo sapiens]                     43   8e-04
gi|89993691 mouse double minute 2 homolog isoform MDM2e [Homo sa...    42   0.001
gi|33946285 baculoviral IAP repeat-containing protein 3 [Homo sa...    42   0.002
gi|4502139 baculoviral IAP repeat-containing protein 3 [Homo sap...    42   0.002
gi|8923040 CDKN2A interacting protein [Homo sapiens]                   41   0.003
gi|4502141 baculoviral IAP repeat-containing protein 2 [Homo sap...    41   0.004
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    41   0.004
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    41   0.004
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    41   0.004
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    41   0.004
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    41   0.004

>gi|58743365 ring finger protein 157 [Homo sapiens]
          Length = 679

 Score = 1375 bits (3559), Expect = 0.0
 Identities = 679/679 (100%), Positives = 679/679 (100%)

Query: 1   MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDSTHPEGYLFGENSDL 60
           MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDSTHPEGYLFGENSDL
Sbjct: 1   MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDSTHPEGYLFGENSDL 60

Query: 61  NFLGNRPVVFPYAAPPPQEPVKTLRSLVNIRKDTLRLVKCAEEVKSPGEEASKAKVHYNV 120
           NFLGNRPVVFPYAAPPPQEPVKTLRSLVNIRKDTLRLVKCAEEVKSPGEEASKAKVHYNV
Sbjct: 61  NFLGNRPVVFPYAAPPPQEPVKTLRSLVNIRKDTLRLVKCAEEVKSPGEEASKAKVHYNV 120

Query: 121 EFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSETVQYKRGVCQQFCLPSHTVDP 180
           EFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSETVQYKRGVCQQFCLPSHTVDP
Sbjct: 121 EFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSETVQYKRGVCQQFCLPSHTVDP 180

Query: 181 SEWAEEELGFDLDREVYPLVVHAVVDEGDEYFGHCHVLLGTFEKHTDGTFCVKPLKQKQV 240
           SEWAEEELGFDLDREVYPLVVHAVVDEGDEYFGHCHVLLGTFEKHTDGTFCVKPLKQKQV
Sbjct: 181 SEWAEEELGFDLDREVYPLVVHAVVDEGDEYFGHCHVLLGTFEKHTDGTFCVKPLKQKQV 240

Query: 241 VDGVSYLLQEIYGIENKYNTQDSKVAEDEVSDNSAECVVCLSDVRDTLILPCRHLCLCNT 300
           VDGVSYLLQEIYGIENKYNTQDSKVAEDEVSDNSAECVVCLSDVRDTLILPCRHLCLCNT
Sbjct: 241 VDGVSYLLQEIYGIENKYNTQDSKVAEDEVSDNSAECVVCLSDVRDTLILPCRHLCLCNT 300

Query: 301 CADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPTSFNPIISSQTSDSEEHPSSENI 360
           CADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPTSFNPIISSQTSDSEEHPSSENI
Sbjct: 301 CADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPTSFNPIISSQTSDSEEHPSSENI 360

Query: 361 PPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSDGHLPPVRTISPLDRLS 420
           PPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSDGHLPPVRTISPLDRLS
Sbjct: 361 PPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSDGHLPPVRTISPLDRLS 420

Query: 421 DSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESE 480
           DSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESE
Sbjct: 421 DSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESE 480

Query: 481 NLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSMSGSYI 540
           NLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSMSGSYI
Sbjct: 481 NLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSMSGSYI 540

Query: 541 APGTEEEGEALSSPQPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEEDGSP 600
           APGTEEEGEALSSPQPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEEDGSP
Sbjct: 541 APGTEEEGEALSSPQPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEEDGSP 600

Query: 601 TQEGQRTCAFLGMECDNNNDFDIASVKALDNKLCSEVCLPGAWQADDNAVSRNAQRRRLS 660
           TQEGQRTCAFLGMECDNNNDFDIASVKALDNKLCSEVCLPGAWQADDNAVSRNAQRRRLS
Sbjct: 601 TQEGQRTCAFLGMECDNNNDFDIASVKALDNKLCSEVCLPGAWQADDNAVSRNAQRRRLS 660

Query: 661 SSSLEDSETRPCVWGPLAV 679
           SSSLEDSETRPCVWGPLAV
Sbjct: 661 SSSLEDSETRPCVWGPLAV 679


>gi|214010238 mahogunin, ring finger 1 isoform 4 [Homo sapiens]
          Length = 531

 Score =  571 bits (1471), Expect = e-163
 Identities = 291/454 (64%), Positives = 349/454 (76%), Gaps = 11/454 (2%)

Query: 1   MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDSTHPEGYLFGENSDL 60
           MG++ SR+ AGVE++DI +NS YRYPPKSG+YFASHF MGGEKFD+ HPEGYLFGEN DL
Sbjct: 1   MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL 60

Query: 61  NFLGNRPVVFPYAAPPPQEPVKTLRSLVNIRKDTLRLVKCAEEVKSPGEEASKAKVHYNV 120
           NFLG+RPV FPY  P P EPVKTLRSLVNIRKD+LRLV+  ++  SP E+  K +V Y++
Sbjct: 61  NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL 120

Query: 121 EFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSETVQYKRGVCQQFCLPSHTVDP 180
           EFTFD DARVAITIY QA+EEF NG A Y PK  SLQSETV YKRGV QQF LPS  +D 
Sbjct: 121 EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF 180

Query: 181 SEWAEEELGFDLDREVYPLVVHAVVDEGD---EYFGHCHVLLGTFEKHTDGTFCVKPLKQ 237
           SEW ++EL FDLDR V+P+V+ AVVDEGD   E  GH HVLL  FEKH DG+F VKPLKQ
Sbjct: 181 SEWKDDELNFDLDRGVFPVVIQAVVDEGDAVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQ 240

Query: 238 KQVVDGVSYLLQEIYGIENKYNTQDSKVAEDEVSDNSAECVVCLSDVRDTLILPCRHLCL 297
           KQ+VD VSYLLQEIYGIENK N Q++K ++DE SDNS ECVVCLSD+RDTLILPCRHLCL
Sbjct: 241 KQIVDRVSYLLQEIYGIENK-NNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCL 299

Query: 298 CNTCADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPTSFNPIISSQTSDSEEHPSS 357
           C +CADTLRYQANNCPICRLPFRALLQIRA+RKK G LSP SF+P++ +Q+ + +EH +S
Sbjct: 300 CTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVL-AQSLEHDEHSNS 358

Query: 358 ENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSDGHLPPVRTISPLD 417
           +++PPGYE +SLLEALNG    SPA+P   +  +   SG+     SDG       ++ +D
Sbjct: 359 DSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGI-----SDGLSQASCPLAAID 413

Query: 418 RLSDSSSQ-GLKLKKSLSKSTSQNSSVLHEEEDE 450
            + DSS Q G    K+   +    SS +HEE++E
Sbjct: 414 HILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEE 447


>gi|214010234 mahogunin, ring finger 1 isoform 2 [Homo sapiens]
          Length = 555

 Score =  571 bits (1471), Expect = e-163
 Identities = 291/454 (64%), Positives = 349/454 (76%), Gaps = 11/454 (2%)

Query: 1   MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDSTHPEGYLFGENSDL 60
           MG++ SR+ AGVE++DI +NS YRYPPKSG+YFASHF MGGEKFD+ HPEGYLFGEN DL
Sbjct: 1   MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL 60

Query: 61  NFLGNRPVVFPYAAPPPQEPVKTLRSLVNIRKDTLRLVKCAEEVKSPGEEASKAKVHYNV 120
           NFLG+RPV FPY  P P EPVKTLRSLVNIRKD+LRLV+  ++  SP E+  K +V Y++
Sbjct: 61  NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL 120

Query: 121 EFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSETVQYKRGVCQQFCLPSHTVDP 180
           EFTFD DARVAITIY QA+EEF NG A Y PK  SLQSETV YKRGV QQF LPS  +D 
Sbjct: 121 EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF 180

Query: 181 SEWAEEELGFDLDREVYPLVVHAVVDEGD---EYFGHCHVLLGTFEKHTDGTFCVKPLKQ 237
           SEW ++EL FDLDR V+P+V+ AVVDEGD   E  GH HVLL  FEKH DG+F VKPLKQ
Sbjct: 181 SEWKDDELNFDLDRGVFPVVIQAVVDEGDAVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQ 240

Query: 238 KQVVDGVSYLLQEIYGIENKYNTQDSKVAEDEVSDNSAECVVCLSDVRDTLILPCRHLCL 297
           KQ+VD VSYLLQEIYGIENK N Q++K ++DE SDNS ECVVCLSD+RDTLILPCRHLCL
Sbjct: 241 KQIVDRVSYLLQEIYGIENK-NNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCL 299

Query: 298 CNTCADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPTSFNPIISSQTSDSEEHPSS 357
           C +CADTLRYQANNCPICRLPFRALLQIRA+RKK G LSP SF+P++ +Q+ + +EH +S
Sbjct: 300 CTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVL-AQSLEHDEHSNS 358

Query: 358 ENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSDGHLPPVRTISPLD 417
           +++PPGYE +SLLEALNG    SPA+P   +  +   SG+     SDG       ++ +D
Sbjct: 359 DSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGI-----SDGLSQASCPLAAID 413

Query: 418 RLSDSSSQ-GLKLKKSLSKSTSQNSSVLHEEEDE 450
            + DSS Q G    K+   +    SS +HEE++E
Sbjct: 414 HILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEE 447


>gi|214010236 mahogunin, ring finger 1 isoform 3 [Homo sapiens]
          Length = 552

 Score =  559 bits (1440), Expect = e-159
 Identities = 291/474 (61%), Positives = 346/474 (72%), Gaps = 30/474 (6%)

Query: 1   MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDSTHPEGYLFGENSDL 60
           MG++ SR+ AGVE++DI +NS YRYPPKSG+YFASHF MGGEKFD+ HPEGYLFGEN DL
Sbjct: 1   MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL 60

Query: 61  NFLGNRPVVFPYAAPPPQEPVKTLRSLVNIRKDTLRLVKCAEEVKSPGEEASKAKVHYNV 120
           NFLG+RPV FPY  P P EPVKTLRSLVNIRKD+LRLV+  ++  SP E+  K +V Y++
Sbjct: 61  NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL 120

Query: 121 EFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSETVQYKRGVCQQFCLPSHTVDP 180
           EFTFD DARVAITIY QA+EEF NG A Y PK  SLQSETV YKRGV QQF LPS  +D 
Sbjct: 121 EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF 180

Query: 181 SEWAEEELGFDLDREVYPLVVHAVVDEGD--EYFGHCHVLLGTFEKHTDGTFCVKPLKQK 238
           SEW ++EL FDLDR V+P+V+ AVVDEGD  E  GH HVLL  FEKH DG+F VKPLKQK
Sbjct: 181 SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK 240

Query: 239 QVVDGVSYLLQEIYGIENKYNTQDSKVAEDEVSDNSAECVVCLSDVRDTLILPCRHLCLC 298
           Q+VD VSYLLQEIYGIENK N Q++K ++DE SDNS ECVVCLSD+RDTLILPCRHLCLC
Sbjct: 241 QIVDRVSYLLQEIYGIENK-NNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLC 299

Query: 299 NTCADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPTSFNPIISSQTSDSEE----- 353
            +CADTLRYQANNCPICRLPFRALLQIRA+RKK G LSP SF+P+++      E      
Sbjct: 300 TSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFK 359

Query: 354 ----HP------------SSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSGM 397
               HP            +S+++PPGYE +SLLEALNG    SPA+P   +  +   SG+
Sbjct: 360 KSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGI 419

Query: 398 LPSYGSDGHLPPVRTISPLDRLSDSSSQ-GLKLKKSLSKSTSQNSSVLHEEEDE 450
                SDG       ++ +D + DSS Q G    K+   +    SS +HEE++E
Sbjct: 420 -----SDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEE 468


>gi|44917608 mahogunin, ring finger 1 isoform 1 [Homo sapiens]
          Length = 576

 Score =  559 bits (1440), Expect = e-159
 Identities = 291/474 (61%), Positives = 346/474 (72%), Gaps = 30/474 (6%)

Query: 1   MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDSTHPEGYLFGENSDL 60
           MG++ SR+ AGVE++DI +NS YRYPPKSG+YFASHF MGGEKFD+ HPEGYLFGEN DL
Sbjct: 1   MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL 60

Query: 61  NFLGNRPVVFPYAAPPPQEPVKTLRSLVNIRKDTLRLVKCAEEVKSPGEEASKAKVHYNV 120
           NFLG+RPV FPY  P P EPVKTLRSLVNIRKD+LRLV+  ++  SP E+  K +V Y++
Sbjct: 61  NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL 120

Query: 121 EFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSETVQYKRGVCQQFCLPSHTVDP 180
           EFTFD DARVAITIY QA+EEF NG A Y PK  SLQSETV YKRGV QQF LPS  +D 
Sbjct: 121 EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF 180

Query: 181 SEWAEEELGFDLDREVYPLVVHAVVDEGD--EYFGHCHVLLGTFEKHTDGTFCVKPLKQK 238
           SEW ++EL FDLDR V+P+V+ AVVDEGD  E  GH HVLL  FEKH DG+F VKPLKQK
Sbjct: 181 SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK 240

Query: 239 QVVDGVSYLLQEIYGIENKYNTQDSKVAEDEVSDNSAECVVCLSDVRDTLILPCRHLCLC 298
           Q+VD VSYLLQEIYGIENK N Q++K ++DE SDNS ECVVCLSD+RDTLILPCRHLCLC
Sbjct: 241 QIVDRVSYLLQEIYGIENK-NNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLC 299

Query: 299 NTCADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPTSFNPIISSQTSDSEE----- 353
            +CADTLRYQANNCPICRLPFRALLQIRA+RKK G LSP SF+P+++      E      
Sbjct: 300 TSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFK 359

Query: 354 ----HP------------SSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSGM 397
               HP            +S+++PPGYE +SLLEALNG    SPA+P   +  +   SG+
Sbjct: 360 KSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGI 419

Query: 398 LPSYGSDGHLPPVRTISPLDRLSDSSSQ-GLKLKKSLSKSTSQNSSVLHEEEDE 450
                SDG       ++ +D + DSS Q G    K+   +    SS +HEE++E
Sbjct: 420 -----SDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEE 468


>gi|217416388 neuralized homolog 1B [Homo sapiens]
          Length = 555

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 23/53 (43%), Positives = 33/53 (62%), Gaps = 1/53 (1%)

Query: 274 SAECVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANN-CPICRLPFRALLQI 325
           + EC VC     DT+I  C H+CLC++C   L+ QA   CPICR P + +++I
Sbjct: 500 NGECTVCFDGEVDTVIYTCGHMCLCHSCGLRLKRQARACCPICRRPIKDVIKI 552


>gi|14042925 ring finger protein 26 [Homo sapiens]
          Length = 433

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 23/52 (44%), Positives = 30/52 (57%), Gaps = 6/52 (11%)

Query: 276 ECVVCLSDVRDTLILPCRHLCLCNTCADTLRYQA---NNCPICRLPFRALLQ 324
           +CV+C    +  L+LPCRHLCLC  C + L        NCP+CR   R +LQ
Sbjct: 379 KCVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPLCR---RGILQ 427


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 72/304 (23%), Positives = 109/304 (35%), Gaps = 43/304 (14%)

Query: 292 CRHLCLCNTCADTLRYQANN---CPICRLPFRALLQIRAMRKKLGPLSPTSFNPIISSQT 348
           CRH C   T  D       N   C  CR+ F+   ++  + K + P  P  F P+     
Sbjct: 507 CRH-CFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDP-PPFMFKPVKEEDD 564

Query: 349 SDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSDGHLP 408
             S +H        G      +  L       PA P      DG  S +     S G   
Sbjct: 565 GLSGKHSMRTRRSRGS-----MSTLRSGRKKQPASP------DGRTSPINEDIRSSGRNS 613

Query: 409 PVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLH-------------EEEDEHSCSE 455
           P    +     S + S+   +KKS  K   + SS L              EE D  S  +
Sbjct: 614 PSAAST-----SSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKK 668

Query: 456 SETQLSQRPSVQHLGEECGVTPESENLTLSSSG---AIDQSSCTGTPLSSTISSPEGPAS 512
           ++TQ   RP+    GE  G + +S ++    S     IDQ + + +P   +    E  + 
Sbjct: 669 TKTQEISRPNSPSEGE--GESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSD 726

Query: 513 SSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEGEGLPAES 572
           SS  Q ++      +   T  + + S   PGT +    L +P P   A +   +G P  S
Sbjct: 727 SSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQ----LPTPGPTPSATAVPPQGSPTAS 782

Query: 573 PDSN 576
              N
Sbjct: 783 QAPN 786


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 72/304 (23%), Positives = 109/304 (35%), Gaps = 43/304 (14%)

Query: 292 CRHLCLCNTCADTLRYQANN---CPICRLPFRALLQIRAMRKKLGPLSPTSFNPIISSQT 348
           CRH C   T  D       N   C  CR+ F+   ++  + K + P  P  F P+     
Sbjct: 507 CRH-CFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPVDP-PPFMFKPVKEEDD 564

Query: 349 SDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSDGHLP 408
             S +H        G      +  L       PA P      DG  S +     S G   
Sbjct: 565 GLSGKHSMRTRRSRGS-----MSTLRSGRKKQPASP------DGRTSPINEDIRSSGRNS 613

Query: 409 PVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLH-------------EEEDEHSCSE 455
           P    +     S + S+   +KKS  K   + SS L              EE D  S  +
Sbjct: 614 PSAAST-----SSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKK 668

Query: 456 SETQLSQRPSVQHLGEECGVTPESENLTLSSSG---AIDQSSCTGTPLSSTISSPEGPAS 512
           ++TQ   RP+    GE  G + +S ++    S     IDQ + + +P   +    E  + 
Sbjct: 669 TKTQEISRPNSPSEGE--GESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSD 726

Query: 513 SSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEGEGLPAES 572
           SS  Q ++      +   T  + + S   PGT +    L +P P   A +   +G P  S
Sbjct: 727 SSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQ----LPTPGPTPSATAVPPQGSPTAS 782

Query: 573 PDSN 576
              N
Sbjct: 783 QAPN 786


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 57/238 (23%), Positives = 100/238 (42%), Gaps = 22/238 (9%)

Query: 337  PTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGH-LS 395
            P S  P++SS+       P   + P    + +  EA + P T    V P+    +G  L 
Sbjct: 2462 PVSTTPVVSSEAGTLSTTPVDTSTP----MTTSTEASSSPTTAEDIVVPISTASEGSTLL 2517

Query: 396  GMLPSYGSDGHLPPVRTIS--PLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSC 453
              +P   +    P   T+S  P+D    +S      + S S ++++ +S+      E S 
Sbjct: 2518 TSIPVSTTPVASPEASTLSTTPVD---SNSPVVTSTEISSSATSAEGTSMPTSTYSEGST 2574

Query: 454  SESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSPEGPASS 513
                  +S +P           TP   ++ +++S     S  T    S  IS+P   ++S
Sbjct: 2575 PLRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTS 2634

Query: 514  --SLAQSVMSMASSQIST------DT---VSSMSGSYIAPGTEEEGEALSSPQPASRA 560
              S+  S M +ASS+ ST      DT   V++ +G+  +P T  EG ++ +  P  R+
Sbjct: 2635 LTSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSP-TTAEGSSMPTSTPGERS 2691



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 55/246 (22%), Positives = 87/246 (35%), Gaps = 29/246 (11%)

Query: 337  PTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHL-- 394
            P +  P+ SS+       P   + P    V +  +A + P T    V P+    +G    
Sbjct: 2816 PVNHTPVASSEAGTLSTTPVDTSTP----VTTSTKASSSPTTAEGIVVPISTASEGSTLL 2871

Query: 395  -------SGMLPSYGSDGHLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEE 447
                   + +  S  S     PV T  P+   ++ SS         S +T++ +S+    
Sbjct: 2872 TSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTEGSS---------SPTTAEGTSMPIST 2922

Query: 448  EDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSP 507
              E S   +   +S  P           TP      +++S     S  T    S  IS+P
Sbjct: 2923 PSEVSTPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTP 2982

Query: 508  EGPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEGEG 567
                +   + SV +M  +     T+S        P T    EA SSP  A      EG G
Sbjct: 2983 GERRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVTTST-EASSSPTTA------EGTG 3035

Query: 568  LPAESP 573
            +P  +P
Sbjct: 3036 IPISTP 3041



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 59/271 (21%), Positives = 104/271 (38%), Gaps = 27/271 (9%)

Query: 300 TCADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPTSFNPIISSQTSDSEEHPSSEN 359
           T   T  Y   + P+   P         M      +S  S  P+ +S    +   PSS  
Sbjct: 322 TSIPTSTYTEGSTPLTSTP------ASTMPVATSEMSTLSITPVDTSTLVTTSTEPSS-- 373

Query: 360 IPPGYEVVSLLEA-LNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSDGHLPPVRTISPLDR 418
           +P   E  S+L + L+   TP   +P   +L       +  S  S     PV + + +  
Sbjct: 374 LPTTAEATSMLTSTLSEGSTPLTNMPVSTIL-------VASSEASTTSTIPVDSKTFVTT 426

Query: 419 LSDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPE 478
            S++SS         S +T++++S+      E S   +   +S  P           TP 
Sbjct: 427 ASEASS---------SPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASSEASNLSTTPV 477

Query: 479 SENLTLSSSGAIDQSSCTGTPLSSTISSPEGPAS--SSLAQSVMSMASSQISTDTVSSMS 536
                +++S     S  T    S   S+P   ++  +S++ S M +ASS+ ST + + + 
Sbjct: 478 DSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTMPVASSEASTLSTTPVD 537

Query: 537 GSYIAPGTEEEGEALSSPQPASRAPSEEGEG 567
            S     + E   + ++P+  S   S   EG
Sbjct: 538 TSTPVTTSSEASSSSTTPEGTSIPTSTPSEG 568



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 54/247 (21%), Positives = 91/247 (36%), Gaps = 34/247 (13%)

Query: 337  PTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGH--- 393
            P S  P+ SS  S     P   + P    V +  EA + P T      P     +G    
Sbjct: 3111 PVSTTPVTSSAISTLSTTPVDTSTP----VTTSTEAHSSPTTSEGTSMPTSTPSEGSTPL 3166

Query: 394  ----LSGMLPSYGSDGHLP--PVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEE 447
                +S ML     D  L   PV T +P+   ++++S           +T++ +S+    
Sbjct: 3167 TYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSS----------TTAEGTSIPTST 3216

Query: 448  EDEHSCSESETQLSQRPSVQHLGEECGVTPESEN--LTLSSSGAIDQSSCTGTPLSSTIS 505
              E     +   +S  P           TP   N  LT S+  +    +  GT + ++  
Sbjct: 3217 PSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTP 3276

Query: 506  SPEGPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEG 565
            S      +S+  S  ++ASS+  T T+S+       P T       +  Q +S  P  +G
Sbjct: 3277 SEGSTPLTSMPVSTTTVASSE--TSTLSTTPADTSTPVT-------TYSQASSSPPIADG 3327

Query: 566  EGLPAES 572
              +P  +
Sbjct: 3328 TSMPTST 3334



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 65/289 (22%), Positives = 100/289 (34%), Gaps = 42/289 (14%)

Query: 300  TCADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPTSFNPI-ISSQTSDSEEHPSSE 358
            T   T  Y   + P+  +P    L + +    L      S  P+  S+  + S E  SS 
Sbjct: 1973 TSMPTPAYSEGSTPLTSMPLSTTLVVSSEASTL------STTPVDTSTPATTSTEGSSSP 2026

Query: 359  NIPPGYEV-VSLLEALNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSDGHLPPVRTISPLD 417
                G  +  S       PL   P    L V  +G+     P                  
Sbjct: 2027 TTAGGTSIQTSTPSERTTPLAGMPVSTTLVVSSEGNTLSTTPV----------------- 2069

Query: 418  RLSDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTP 477
               DS +Q     ++ S +T++ SS+      E S   +   LS  P           TP
Sbjct: 2070 ---DSKTQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIPLSTTPVASPEASTLSTTP 2126

Query: 478  ESENLTLSSSGAIDQSSCT--GTPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSM 535
               N  + +S  +  S     GT + ++  S      +S+  S   +ASS IST + + +
Sbjct: 2127 VDSNSPVITSTEVSSSPIPTEGTSMQTSTYSDRRTPLTSMPVSTTVVASSAISTLSTTPV 2186

Query: 536  SGSYIAPGTEEEGEALSSPQPASRAPSEEGEGLPAESPDSN---FAGLP 581
              S   P T    EA SSP       + EG  +P  +P      F  +P
Sbjct: 2187 DTS--TPVTNST-EARSSP------TTSEGTSMPTSTPSEGSTPFTSMP 2226



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 56/246 (22%), Positives = 104/246 (42%), Gaps = 39/246 (15%)

Query: 342  PIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDG--------- 392
            P+ SS  S     P   + P    V +  EA + P T      P     +G         
Sbjct: 1701 PVASSAISTLSTTPVDNSTP----VTTSTEARSSPTTSEGTSMPNSTPSEGTTPLTSIPV 1756

Query: 393  HLSGMLPSYGSDGHLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHS 452
              + +L S  S     P+ T +P+   ++++S         S +T++ +S+        +
Sbjct: 1757 STTPVLSSEASTLSATPIDTSTPVTTSTEATS---------SPTTAEGTSI-----PTST 1802

Query: 453  CSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSS--CTGTPLSSTISSPEGP 510
             SE  T L+  P V H      +   SE  TLS++  +D +S   T T +SS+ +  EG 
Sbjct: 1803 LSEGMTPLTSTP-VSHT-----LVANSEASTLSTT-PVDSNSPVVTSTAVSSSPTPAEGT 1855

Query: 511  --ASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAP-SEEGEG 567
              A+S+ ++   ++ S  +ST TV+S   + ++         +++    S +P + +G  
Sbjct: 1856 SIATSTPSEGSTALTSIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQVSSSPTTADGSS 1915

Query: 568  LPAESP 573
            +P  +P
Sbjct: 1916 MPTSTP 1921



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 58/246 (23%), Positives = 96/246 (39%), Gaps = 29/246 (11%)

Query: 337  PTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLS- 395
            P S  P+ SS+ S     P   +IP    V +  E  + P T      P+    +   S 
Sbjct: 2580 PVSTKPLASSEASTLSTTPVDTSIP----VTTSTETSSSPTTAKDTSMPISTPSEVSTSL 2635

Query: 396  -----GMLPSYGSDGHLPPVRTISPLD-RLSDSSSQGLKLKKSLSKSTSQNSSVLHEEED 449
                   +P   S+       + +P+D R   ++S G     S S +T++ SS+      
Sbjct: 2636 TSILVSTMPVASSEAS---TLSTTPVDTRTLVTTSTGT----SSSPTTAEGSSMPTSTPG 2688

Query: 450  EHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSPEG 509
            E S   +   +S              TP   +  +++S     S  T    S  IS+P  
Sbjct: 2689 ERSTPLTNILVSTTLLANSEASTLSTTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSD 2748

Query: 510  PAS--SSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEGEG 567
             ++  +S+  S + +ASS+ ST + +++  S   P T    EA SSP  A      E   
Sbjct: 2749 GSTPLTSILVSTLPVASSEASTVSTTAVDTS--IPVTTST-EASSSPTTA------EVTS 2799

Query: 568  LPAESP 573
            +P  +P
Sbjct: 2800 MPTSTP 2805



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 55/246 (22%), Positives = 87/246 (35%), Gaps = 29/246 (11%)

Query: 337  PTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLS- 395
            P S  P++SS+ +     P   N      V +  EA + P        P     +G    
Sbjct: 3405 PVSTTPVVSSEVNTLSTTPVDSNTL----VTTSTEASSSPTIAEGTSLPTSTTSEGSTPL 3460

Query: 396  GMLP--------SYGSDGHLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEE 447
             ++P        S  S     PV T +P+   S ++S         S +T++ +S+    
Sbjct: 3461 SIMPLSTTPVASSEASTLSTTPVDTSTPVTTSSPTNS---------SPTTAEVTSMPTST 3511

Query: 448  EDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSP 507
              E S   +   +S  P           TP   N  ++SS     S  T    +  +S+P
Sbjct: 3512 AGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASSSPATLQVTTMRMSTP 3571

Query: 508  EGPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEGEG 567
                SSSL   ++S      ST   SS + +   P  +      +S Q  S     E   
Sbjct: 3572 -SEGSSSLTTMLLS------STYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPEVIT 3624

Query: 568  LPAESP 573
            LP  +P
Sbjct: 3625 LPMSTP 3630



 Score = 37.4 bits (85), Expect = 0.046
 Identities = 43/220 (19%), Positives = 83/220 (37%), Gaps = 13/220 (5%)

Query: 367 VSLLEALNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSDGHLPPVRTISPLDRLSDSSSQG 426
           V+  EA     TP     P+    +   S   P   S     P    +PL  +  S+   
Sbjct: 523 VASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTNMPVSTRLV 582

Query: 427 LKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSS 486
           +  + S + +T  +S+       E S S +  + +  P+  +      +T  S + TL +
Sbjct: 583 VSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVSTTLVA 642

Query: 487 SGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASS------------QISTDTVSS 534
           S      S T    ++ +++     SSS      SM +S             ++T  V+S
Sbjct: 643 SSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNTTLVAS 702

Query: 535 MSGSYIAPGTEEEGEALSSPQPASRAP-SEEGEGLPAESP 573
              S ++    +    +++   AS +P + +G  +P  +P
Sbjct: 703 SEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTP 742



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 57/245 (23%), Positives = 92/245 (37%), Gaps = 12/245 (4%)

Query: 337 PTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSG 396
           P +   + SS+ S     P   + P    V +  EA + P T   A  P     +G  S 
Sbjct: 694 PVNTTLVASSEASTLSTTPVDTSTP----VTTSTEASSSPTTADGASMPTSTPSEG--ST 747

Query: 397 MLPSYGSDGHLPPVRTISPLDR--LSDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCS 454
            L S      L      S L    L  S+      + S S +T++ +S+      E S  
Sbjct: 748 PLTSMPVSKTLLTSSEASTLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPL 807

Query: 455 ESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSS--CTGTPLSSTISSPEGPAS 512
            +   +S  P           TP   N  +++S  +  S     GT + ++  S      
Sbjct: 808 LTSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMPTSTYSEGRTPL 867

Query: 513 SSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEGEG-LPAE 571
           +S+  S   +A+S IST + + +  S     + E   + ++ +  S   S  GEG  P  
Sbjct: 868 TSMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPGEGSTPLT 927

Query: 572 S-PDS 575
           S PDS
Sbjct: 928 SMPDS 932



 Score = 33.9 bits (76), Expect = 0.51
 Identities = 52/247 (21%), Positives = 93/247 (37%), Gaps = 33/247 (13%)

Query: 337  PTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGH--L 394
            P S  P+ S + S     P   N P    V++  E  + P+             D    L
Sbjct: 2108 PLSTTPVASPEASTLSTTPVDSNSP----VITSTEVSSSPIPTEGTSMQTSTYSDRRTPL 2163

Query: 395  SGM-------LPSYGSDGHLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEE 447
            + M         S  S     PV T +P+   +++ S         S +TS+ +S+    
Sbjct: 2164 TSMPVSTTVVASSAISTLSTTPVDTSTPVTNSTEARS---------SPTTSEGTSMPTST 2214

Query: 448  EDEHSCSESETQLSQRPSVQHLGEECGVTP--ESENLTLSSSGAIDQSSCTGTPLSSTIS 505
              E S   +   +S  P V         TP   S  +T S+      ++  GT + ++  
Sbjct: 2215 PSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTL 2274

Query: 506  SPEGPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEG 565
            S      +S+  S   +A+S++ST + + +  +   P T       +S + +S  P+ EG
Sbjct: 2275 SEGTTPLTSIPVSHTLVANSEVSTLSTTPVDSN--TPFT-------TSTEASSPPPTAEG 2325

Query: 566  EGLPAES 572
              +P  +
Sbjct: 2326 TSMPTST 2332



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 56/272 (20%), Positives = 94/272 (34%), Gaps = 45/272 (16%)

Query: 337  PTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHL-- 394
            P S   + +S+ S     P   N P      +  EA + P T      P     +G+   
Sbjct: 2285 PVSHTLVANSEVSTLSTTPVDSNTP----FTTSTEASSPPPTAEGTSMPTSTSSEGNTPL 2340

Query: 395  ------SGMLPSYGSDG-HLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEE 447
                  + M+ S+ +      P  T +P+   S + S         S +T+ ++S+    
Sbjct: 2341 TRMPVSTTMVASFETSTLSTTPADTSTPVTTYSQAGS---------SPTTADDTSMPTST 2391

Query: 448  EDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTG---------- 497
              E S   +   +S  P V         TP   +  +++S     S  T           
Sbjct: 2392 YSEGSTPLTSVPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPP 2451

Query: 498  ----TPLSS-------TISSPEGPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEE 546
                TPL+S        +SS  G  S++   +   M +S  ++ + ++     +   T  
Sbjct: 2452 SEGTTPLASMPVSTTPVVSSEAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTAS 2511

Query: 547  EGEALSSPQPASRAP--SEEGEGLPAESPDSN 576
            EG  L +  P S  P  S E   L     DSN
Sbjct: 2512 EGSTLLTSIPVSTTPVASPEASTLSTTPVDSN 2543



 Score = 33.1 bits (74), Expect = 0.87
 Identities = 54/258 (20%), Positives = 100/258 (38%), Gaps = 30/258 (11%)

Query: 336 SPTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLS 395
           SPT+       ++++SE      ++P     V+  EA+    TP     P+ +      S
Sbjct: 197 SPTTPESTTIPKSTNSEGSTPLTSMPASTMKVASSEAITLLTTPVEISTPVTISAQASSS 256

Query: 396 GMLPSYGSDGHLPPVRTISPLDRLSDS-----SSQGLKL---------------KKSLSK 435
                  S  +  P    +PL R+  S     SS+   L               + S S 
Sbjct: 257 PTTAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTPAATNIPVITSTEASSSP 316

Query: 436 STSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSS---GAIDQ 492
           +T++ +S+      E S   + T  S  P          +TP   +  +++S    ++  
Sbjct: 317 TTAEGTSIPTSTYTEGSTPLTSTPASTMPVATSEMSTLSITPVDTSTLVTTSTEPSSLPT 376

Query: 493 SSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALS 552
           ++   + L+ST+S    P ++    +++  +S   +T T+   S +++   +    EA S
Sbjct: 377 TAEATSMLTSTLSEGSTPLTNMPVSTILVASSEASTTSTIPVDSKTFVTTAS----EASS 432

Query: 553 SPQPA---SRAPSEEGEG 567
           SP  A   S A S   EG
Sbjct: 433 SPTTAEDTSIATSTPSEG 450



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 51/247 (20%), Positives = 92/247 (37%), Gaps = 33/247 (13%)

Query: 337  PTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGH--L 394
            P S   + +S  S     P   + P    V +  EA + P T      P    G+G   L
Sbjct: 871  PVSTTLVATSAISTLSTTPVDTSTP----VTNSTEARSSPTTSEGTSMPTSTPGEGSTPL 926

Query: 395  SGM----LPSYGSDGHL---PPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEE 447
            + M     P   S+       PV T +P+   ++++S         S +T++ +S+    
Sbjct: 927  TSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATS---------SPTTAEGTSIPTST 977

Query: 448  EDEHSCSESETQLSQRPSVQHLGEECGVTPESEN--LTLSSSGAIDQSSCTGTPLSSTIS 505
              E +   + T +S              TP   N  LT S+  +    +  GT + ++  
Sbjct: 978  PSEGTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTSTP 1037

Query: 506  SPEGPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEG 565
            S      + +  S   +ASS+  T T+S+       P T       +  Q +S + + +G
Sbjct: 1038 SEGSTPLTRMPVSTTMVASSE--TSTLSTTPADTSTPVT-------TYSQASSSSTTADG 1088

Query: 566  EGLPAES 572
              +P  +
Sbjct: 1089 TSMPTST 1095



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 57/255 (22%), Positives = 102/255 (40%), Gaps = 24/255 (9%)

Query: 336  SPTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEAL---------NGPLTPSPAVPPL 386
            SPT+   I    ++ SE     ++IP     V+  EA          N P+  S AV   
Sbjct: 1436 SPTTAEGISIPTSTPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPVVTSTAVSSS 1495

Query: 387  HVLGDG-HLSGMLPSYGSDGHLP-PVRTI----SPLDRLSDSSSQGLKLKKSLSKSTSQN 440
                +G  ++   PS GS      PV T     S ++ LS + +       + S+++S  
Sbjct: 1496 PTPAEGTSIAISTPSEGSTALTSIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSP 1555

Query: 441  SSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPL 500
            ++         + SE  T L+  P    L         SE  TLS++    ++  T +  
Sbjct: 1556 TTADGTSMQTSTYSEGSTPLTSLPVSTML------VVSSEANTLSTTPIDSKTQVTASTE 1609

Query: 501  SSTISSPEGPASSSLAQSVMS--MASSQISTDTVSSMSGSYIA-PGTEEEGEALSSPQPA 557
            +S+ ++ EG + +    S  S  + S  +ST  V+S   S ++    +     ++S + +
Sbjct: 1610 ASSSTTAEGSSMTISTPSEGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVS 1669

Query: 558  SRAPSEEGEGLPAES 572
            S     EG  +P  +
Sbjct: 1670 SSPTPAEGTSMPTST 1684



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 45/205 (21%), Positives = 75/205 (36%), Gaps = 26/205 (12%)

Query: 337  PTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLT----------PSPAVPPL 386
            P +   + SS  S     P   + P    V +  EA + P T          PS    PL
Sbjct: 1343 PVNTTLVASSAISILSTTPVDNSTP----VTTSTEACSSPTTSEGTSMPNSNPSEGTTPL 1398

Query: 387  HVLGDGHLSGMLPSYGSDGHLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHE 446
              +     + ++ S  S     PV T +P    ++++S         S +T++  S+   
Sbjct: 1399 TSIPVS-TTPVVSSEASTLSATPVDTSTPGTTSAEATS---------SPTTAEGISIPTS 1448

Query: 447  EEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISS 506
               E         +S  P           TP   N  + +S A+  S       S  IS+
Sbjct: 1449 TPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIAIST 1508

Query: 507  PE--GPASSSLAQSVMSMASSQIST 529
            P     A +S+  S  ++ASS+I++
Sbjct: 1509 PSEGSTALTSIPVSTTTVASSEINS 1533



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 52/252 (20%), Positives = 95/252 (37%), Gaps = 42/252 (16%)

Query: 337  PTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSG 396
            P S   + SS+T+     P+  + P    V +  +  + P T   +  P     +G    
Sbjct: 1873 PVSTTTVASSETNTLSTTPAVTSTP----VTTYAQVSSSPTTADGSSMPTSTPREGR--- 1925

Query: 397  MLPSYGSDGHLPPVRTISPLDRLSDSSSQGLKLKKSL----------SKSTSQNSSVLHE 446
                       PP+ +I P+   + +SS+   L  +L          S+++S  ++    
Sbjct: 1926 -----------PPLTSI-PVSTTTVASSEINTLSTTLADTRTPVTTYSQASSSPTTADGT 1973

Query: 447  EEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISS 506
                 + SE  T L+  P    L         SE  TLS++     +S   T  +   SS
Sbjct: 1974 SMPTPAYSEGSTPLTSMPLSTTL------VVSSEASTLSTTPV--DTSTPATTSTEGSSS 2025

Query: 507  PEGPASSSLAQSVMS-----MASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAP 561
            P     +S+  S  S     +A   +ST  V S  G+ ++    +    +++   AS + 
Sbjct: 2026 PTTAGGTSIQTSTPSERTTPLAGMPVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEASSSA 2085

Query: 562  SEEGEGLPAESP 573
            + EG  +   +P
Sbjct: 2086 TAEGSSMTISAP 2097



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 30/126 (23%), Positives = 50/126 (39%), Gaps = 5/126 (3%)

Query: 456  SETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSS-CTGTPLSST--ISSPEGPAS 512
            S T +     V    E C     SE  ++ +S   + ++  T  P+S+T  +SS     S
Sbjct: 1358 STTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTPLTSIPVSTTPVVSSEASTLS 1417

Query: 513  SSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAP--SEEGEGLPA 570
            ++   +     +S  +T + ++  G  I   T  EG+      P S  P  + E   L  
Sbjct: 1418 ATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEGKTPLKSIPVSNTPVANSEASTLST 1477

Query: 571  ESPDSN 576
               DSN
Sbjct: 1478 TPVDSN 1483


>gi|5729765 cell growth regulator with ring finger domain 1 [Homo
           sapiens]
          Length = 332

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 23/60 (38%), Positives = 34/60 (56%), Gaps = 6/60 (10%)

Query: 257 KYNTQDSKVAEDEVSDNSAECVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICR 316
           K    +S+V   E  +NS +CVVC +   + ++LPCRH CLC+ C    +     CP+CR
Sbjct: 256 KVGLSESEVEPSE--ENSKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQ----QCPMCR 309


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 53/248 (21%), Positives = 97/248 (39%), Gaps = 7/248 (2%)

Query: 420 SDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPES 479
           S  SS       S S S S NSS   +  D  + SES        S      +   +  S
Sbjct: 665 SSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSS 724

Query: 480 ENLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSMSGSY 539
           ++ + +SS + D S+ + +  SS  S+    + SS + +    + S  S+D+  S + S 
Sbjct: 725 DSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSD 784

Query: 540 IAPGTEEEGEALSSPQPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEEDGS 599
               +     + SS    S   S+  +   ++S DS+ +        ++ +D     D S
Sbjct: 785 SNDSSNSSDSSDSSNSSDSSNSSDSSDS--SDSSDSDSSNSSDSSNSSDSSDSSNSSDSS 842

Query: 600 PTQEGQRTCAFLGMECDNNNDFDIASVKALDNKLCSEVCLPGAWQADDNAVSRNAQRRRL 659
            + +        G + D++N  D ++     +   S      +  +D N  S ++     
Sbjct: 843 DSSDSSD-----GSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDS 897

Query: 660 SSSSLEDS 667
           S+SS  DS
Sbjct: 898 SNSSDSDS 905



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 54/250 (21%), Positives = 98/250 (39%), Gaps = 25/250 (10%)

Query: 420 SDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPES 479
           SDSS+       S S S+  NSS   +  D  S   S++  S              +  S
Sbjct: 555 SDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSD-------------SSNS 601

Query: 480 ENLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSMSGSY 539
            + + SS  +    S   +   S  S  E  +S S ++S  S ++S  S+D   S   S 
Sbjct: 602 SDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSN 661

Query: 540 IAPGTEEEGEALSSPQPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEEDGS 599
            +  ++    + SS   +S   S   +   ++S DS+ +   +   D+  +D  +  D S
Sbjct: 662 SSNSSDSSDSSDSSDSSSSSDSSNSSDS--SDSSDSSNSSESSDSSDSSDSDSSDSSDSS 719

Query: 600 PTQEGQRTCAFLGMECDNNNDFDIASVKALDNKLCSEVCLPGAWQADDNAVSRNAQRRRL 659
            +       +      D++N  D  S  + D+   S+        + D++ S N+     
Sbjct: 720 NSNSSDSDSSNSSDSSDSSNSSD--SSDSSDSSNSSD--------SSDSSDSSNSSDSSD 769

Query: 660 SSSSLEDSET 669
           SS S + S++
Sbjct: 770 SSDSSDSSDS 779



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 54/254 (21%), Positives = 98/254 (38%), Gaps = 4/254 (1%)

Query: 417 DRLSDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVT 476
           D  SDSS        S SKS S +S+     ++  S   S +  S   S      +   +
Sbjct: 621 DSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSS 680

Query: 477 PESENLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSMS 536
            +S N +  SS + D S+ + +  SS  S  +   SS  + S  S + S  S+D+  S +
Sbjct: 681 SDSSN-SSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSN 739

Query: 537 GSYIAPGTEEEGEALSSPQPASRAPSEEGEGLPA--ESPDSNFAGLPAGEQDAEGNDVIE 594
            S  +  ++    + SS    S   S+  +   +   S  SN +        ++ +D   
Sbjct: 740 SSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSN 799

Query: 595 EEDGSPTQEGQRTCAFLGMECDNNNDFDIASVKA-LDNKLCSEVCLPGAWQADDNAVSRN 653
             D S + +   +      +  N++D   +S  +   N   S      +  +D ++ +R+
Sbjct: 800 SSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRS 859

Query: 654 AQRRRLSSSSLEDS 667
                  SS   DS
Sbjct: 860 DSSNSSDSSDSSDS 873



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 52/272 (19%), Positives = 102/272 (37%), Gaps = 10/272 (3%)

Query: 400  SYGSDGHLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQ 459
            S  SDG        S     SDSS        S S  +S ++   +  +   S + S++ 
Sbjct: 845  SDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSD 904

Query: 460  LSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSV 519
             S   +     +    +  SE+   S +     SS +     S+ SS    +S+S   S 
Sbjct: 905  SSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSN 964

Query: 520  MSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEGEGLPA--ESPDSNF 577
             S +S   S+D+  S + S  +  ++    + SS    S   S+  +   +   S  SN 
Sbjct: 965  SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024

Query: 578  AGLPAGEQDAEGNDVIEEEDGSPTQEGQRTCAFLGMECDNNNDFDIASVKALDNKLCSEV 637
            +        ++ +D  +  D S + +          +  N++D   +S  +  +      
Sbjct: 1025 SDSSNSSDSSDSSDSSDSSDSSDSSDSS--------DSSNSSDSSDSSDSSDSSDSSDSS 1076

Query: 638  CLPGAWQADDNAVSRNAQRRRLSSSSLEDSET 669
                + ++ D++ S N+     SS S + S++
Sbjct: 1077 DSSDSSESSDSSDSSNSSDSSDSSDSSDSSDS 1108



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 54/259 (20%), Positives = 109/259 (42%), Gaps = 22/259 (8%)

Query: 420 SDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEE------- 472
           ++SSS+G     S     + N S     ED+ S S S+T  S      + G +       
Sbjct: 483 NNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDS 542

Query: 473 -CGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQISTDT 531
             G +  S++ +  SS + D S  + +  S + SS +  +S S +       SS  S  +
Sbjct: 543 GKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSS 602

Query: 532 VSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEGEG-LPAESPDSNFAGLPAGEQDAEGN 590
            SS S    +  + +  ++  S   +S++ S+  +    ++S DSN +        ++ +
Sbjct: 603 DSSDSSD--SSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSS 660

Query: 591 DVIEEEDGSPTQEGQRTCAFLGMECDNNNDFDIASVKALDNKLCSEVCLPGAWQADDNAV 650
           +     D S + +   + +      D++N  D  S  + D+   SE     +  + D++ 
Sbjct: 661 NSSNSSDSSDSSDSSDSSS----SSDSSNSSD--SSDSSDSSNSSE-----SSDSSDSSD 709

Query: 651 SRNAQRRRLSSSSLEDSET 669
           S ++     S+S+  DS++
Sbjct: 710 SDSSDSSDSSNSNSSDSDS 728



 Score = 38.1 bits (87), Expect = 0.027
 Identities = 37/180 (20%), Positives = 71/180 (39%), Gaps = 5/180 (2%)

Query: 420  SDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPES 479
            SDSS+       S S  +S +S+     +   S   S++  S   S      +   + +S
Sbjct: 1118 SDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDS 1177

Query: 480  ENLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSMSGSY 539
             N + SS  +    S   +  S +  S +   SS  + S  S  SS  S  + S+ S   
Sbjct: 1178 SNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSD- 1236

Query: 540  IAPGTEEEGEALSSPQPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEEDGS 599
                + +  ++  S   +  + S +     ++S D + +   +G  +  G+D   + +GS
Sbjct: 1237 ----SSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGS 1292



 Score = 34.7 bits (78), Expect = 0.30
 Identities = 39/186 (20%), Positives = 69/186 (37%), Gaps = 1/186 (0%)

Query: 420  SDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPES 479
            SDSS        S S ++S +S      +   S + S++  S   S      +   + +S
Sbjct: 1106 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDS 1165

Query: 480  ENLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSS-MSGS 538
             + + SS  +   +S   +  S +  S +   SS  + S  S  SS  S  + SS  S S
Sbjct: 1166 SDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1225

Query: 539  YIAPGTEEEGEALSSPQPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEEDG 598
              +  + E  ++  S   +  + S +       S  ++ +   +  Q   GN      D 
Sbjct: 1226 SDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDS 1285

Query: 599  SPTQEG 604
                EG
Sbjct: 1286 DSDSEG 1291


>gi|223278368 neuralized-like [Homo sapiens]
          Length = 574

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 20/52 (38%), Positives = 29/52 (55%), Gaps = 1/52 (1%)

Query: 274 SAECVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANN-CPICRLPFRALLQ 324
           S EC +C     DT+I  C H+CLC  C   L+   +  CPICR P + +++
Sbjct: 518 SDECTICYEHAVDTVIYTCGHMCLCYACGLRLKKALHACCPICRRPIKDIIK 569


>gi|53729363 leucine rich repeat and sterile alpha motif containing
           1 [Homo sapiens]
          Length = 723

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 21/57 (36%), Positives = 28/57 (49%), Gaps = 4/57 (7%)

Query: 269 EVSDNSAECVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICRLPFRALLQI 325
           E+   ++ECVVCL      + L C H+C C  C   LR     CP+CR      L+I
Sbjct: 667 ELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLR----TCPLCRQDIAQRLRI 719


>gi|53729361 leucine rich repeat and sterile alpha motif containing
           1 [Homo sapiens]
          Length = 723

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 21/57 (36%), Positives = 28/57 (49%), Gaps = 4/57 (7%)

Query: 269 EVSDNSAECVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICRLPFRALLQI 325
           E+   ++ECVVCL      + L C H+C C  C   LR     CP+CR      L+I
Sbjct: 667 ELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLR----TCPLCRQDIAQRLRI 719


>gi|53729359 leucine rich repeat and sterile alpha motif containing
           1 [Homo sapiens]
          Length = 723

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 21/57 (36%), Positives = 28/57 (49%), Gaps = 4/57 (7%)

Query: 269 EVSDNSAECVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICRLPFRALLQI 325
           E+   ++ECVVCL      + L C H+C C  C   LR     CP+CR      L+I
Sbjct: 667 ELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLR----TCPLCRQDIAQRLRI 719


>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
          Length = 2968

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 41/143 (28%), Positives = 60/143 (41%), Gaps = 9/143 (6%)

Query: 420  SDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPES 479
            S+SSS       S S S+S + S    EE+     +              G  C      
Sbjct: 2557 SESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTG--------GRNCSAASSR 2608

Query: 480  ENLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSMSGSY 539
                 SSS +   SS + +  SS+ SS    +SSS + S  S +SS  S+ + SS S S 
Sbjct: 2609 AASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS- 2667

Query: 540  IAPGTEEEGEALSSPQPASRAPS 562
             +  T +E  + SS   A+ AP+
Sbjct: 2668 SSSSTTDEDSSCSSDDEAAPAPT 2690



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 47/166 (28%), Positives = 71/166 (42%), Gaps = 20/166 (12%)

Query: 420  SDSSSQGLKLKKSLSKSTSQNSSVLHEEEDE-----------HSCSESETQLSQRPSVQH 468
            S SSS G     S S S+S  S    EEE +            +CS + ++ +   S   
Sbjct: 2560 SSSSSSGSS--SSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPAS--- 2614

Query: 469  LGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQIS 528
                   +  S + + SSS +   SS + +  SS+ SS    +SSS + S  S +SS  +
Sbjct: 2615 --SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSST 2672

Query: 529  TDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEGEGLP-AESP 573
            TD  SS S    A      G +  +  P ++A  + G+  P A SP
Sbjct: 2673 TDEDSSCSSDDEAAPAPTAGPSAQAALP-TKATKQAGKARPSAHSP 2717



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 35/130 (26%), Positives = 50/130 (38%), Gaps = 3/130 (2%)

Query: 447  EEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISS 506
            EE E S S S    S   S    G E   T   E    +  G         +  SS  +S
Sbjct: 2555 EESESSSSSSSGSSSSSSSSSSSGSE---TEGEEEGDKNGDGGCGTGGRNCSAASSRAAS 2611

Query: 507  PEGPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEGE 566
            P   +SSS + S  S +SS  S+ + SS S S  +  +     + SS   +S + S    
Sbjct: 2612 PASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2671

Query: 567  GLPAESPDSN 576
                +S  S+
Sbjct: 2672 TTDEDSSCSS 2681



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 41/172 (23%), Positives = 59/172 (34%), Gaps = 27/172 (15%)

Query: 390  GDGHLSGMLPSYGSDGHLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEEED 449
            GD +  G   + G +      R  SP    S SSS       S S S+S +SS       
Sbjct: 2587 GDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2646

Query: 450  EHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSPEG 509
              S S S +  S                       SSS +   SS + T   S+ SS + 
Sbjct: 2647 SSSSSSSSSSSSS----------------------SSSSSSSSSSSSTTDEDSSCSSDDE 2684

Query: 510  PASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAP 561
             A +  A       S+Q +  T ++       P     G+   +PQP +  P
Sbjct: 2685 AAPAPTAG-----PSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPP 2731



 Score = 30.0 bits (66), Expect = 7.3
 Identities = 39/174 (22%), Positives = 68/174 (39%), Gaps = 10/174 (5%)

Query: 411  RTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSE-SETQLSQRPSVQHL 469
            RT+ P    S      L L+++ ++S+  +SS    ++DE S  E  E +L +       
Sbjct: 1786 RTLKPKPATSRKQPFCLLLREAEARSSFSDSSEESFDQDESSEEEDEEEELEEEDEASGG 1845

Query: 470  GEECGVTPE--SENLTLSSSGAIDQSSCTGTPL-----SSTISSPEGPASSSLAQSVMSM 522
            G   G      S  L  S  G + + + +  P      S ++   E    +   +   S+
Sbjct: 1846 GYRLGARERALSPGLEESGLGLLARFAASALPSPTVGPSLSVVQLEAKQKARKKEERQSL 1905

Query: 523  ASSQIS-TDTVSSMSGSYIAP-GTEEEGEALSSPQPASRAPSEEGEGLPAESPD 574
              ++   TD+ S +     +P G     + L  P P+  AP+    G    SPD
Sbjct: 1906 LGTEFEYTDSESEVKVRKRSPAGLLRPKKGLGEPGPSLAAPTPGARGPDPSSPD 1959


>gi|171542821 mitochondrial ubiquitin ligase activator of NFKB 1
           [Homo sapiens]
          Length = 352

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 23/50 (46%), Positives = 27/50 (54%), Gaps = 2/50 (4%)

Query: 267 EDEVSDNSAECVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICR 316
           ED  S  SA CVVCLS  +  + L C H+C C  C   L  +   CPICR
Sbjct: 293 EDRESLKSA-CVVCLSSFKSCVFLECGHVCSCTECYRALP-EPKKCPICR 340


>gi|57165361 ring finger protein 165 [Homo sapiens]
          Length = 346

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 27/72 (37%), Positives = 32/72 (44%), Gaps = 6/72 (8%)

Query: 257 KYNTQDSKVAEDE--VSDNSAECVVCLS---DVRDTLILPCRHLCLCNTCADTLRYQANN 311
           K   QD K  +DE   SD   +C +CLS   D  D   LPC HL     C D     +  
Sbjct: 272 KRRPQDGKGKKDEGEESDTDEKCTICLSMLEDGEDVRRLPCMHL-FHQLCVDQWLAMSKK 330

Query: 312 CPICRLPFRALL 323
           CPICR+     L
Sbjct: 331 CPICRVDIETQL 342


>gi|21361493 ring finger protein 141 [Homo sapiens]
          Length = 230

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 21/42 (50%), Positives = 24/42 (57%), Gaps = 2/42 (4%)

Query: 276 ECVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICRL 317
           EC +C+ D R  LILPC H   C  C D    +  NCPICRL
Sbjct: 154 ECCICM-DGRADLILPCAH-SFCQKCIDKWSDRHRNCPICRL 193


>gi|89993691 mouse double minute 2 homolog isoform MDM2e [Homo
           sapiens]
          Length = 179

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 28/99 (28%), Positives = 52/99 (52%), Gaps = 11/99 (11%)

Query: 236 KQKQVVDGVSYLLQEIYGIEN-------KYNTQDSKVA-EDEVSDNSAE-CVVCLSDVRD 286
           KQ+ +V   + LL +++G+ +       +  TQD + + E  +  N+ E CV+C    ++
Sbjct: 76  KQQHIVYCSNDLLGDLFGVPSFSVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKN 135

Query: 287 TLILPCR--HLCLCNTCADTLRYQANNCPICRLPFRALL 323
             I+  +  HL  C TCA  L+ +   CP+CR P + ++
Sbjct: 136 GCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIV 174


>gi|33946285 baculoviral IAP repeat-containing protein 3 [Homo
           sapiens]
          Length = 604

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 28/83 (33%), Positives = 39/83 (46%), Gaps = 18/83 (21%)

Query: 248 LQEIYGI--ENKYNTQDSK-VAEDEVSDNSAE-----------CVVCLSDVRDTLILPCR 293
           LQE   +  E+ +  QD K +  ++VSD   E           C VC+      + +PC 
Sbjct: 514 LQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCG 573

Query: 294 HLCLCNTCADTLRYQANNCPICR 316
           HL +C  CA +LR     CPICR
Sbjct: 574 HLVVCKDCAPSLR----KCPICR 592


>gi|4502139 baculoviral IAP repeat-containing protein 3 [Homo
           sapiens]
          Length = 604

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 28/83 (33%), Positives = 39/83 (46%), Gaps = 18/83 (21%)

Query: 248 LQEIYGI--ENKYNTQDSK-VAEDEVSDNSAE-----------CVVCLSDVRDTLILPCR 293
           LQE   +  E+ +  QD K +  ++VSD   E           C VC+      + +PC 
Sbjct: 514 LQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCG 573

Query: 294 HLCLCNTCADTLRYQANNCPICR 316
           HL +C  CA +LR     CPICR
Sbjct: 574 HLVVCKDCAPSLR----KCPICR 592


>gi|8923040 CDKN2A interacting protein [Homo sapiens]
          Length = 580

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 49/167 (29%), Positives = 78/167 (46%), Gaps = 15/167 (8%)

Query: 414 SPLDRLSDSSSQGLKLKKSL----SKSTSQNSSVLHEEEDEHSCSESETQL---SQRPSV 466
           S + + +DS  Q    KKS     S S SQ+SS + E     S   SE +L   S +PS 
Sbjct: 254 SHMTQSTDSRQQSGSPKKSALEGSSASASQSSSEI-EVPLLGSSGSSEVELPLLSSKPSS 312

Query: 467 QHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQ 526
           +      G+T ++ +    SS     SS +GT L +  SS     S   ++S   +A+S 
Sbjct: 313 ETASS--GLTSKTSSEASVSSSVAKNSSSSGTSLLTPKSSSSTNTSLLTSKSTSQVAASL 370

Query: 527 ISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEGEG-LPAES 572
           +++ + S  SGS ++  T       S  Q AS++ S+     LP++S
Sbjct: 371 LASKSSSQTSGSLVSKST----SLASVSQLASKSSSQTSTSQLPSKS 413


>gi|4502141 baculoviral IAP repeat-containing protein 2 [Homo
           sapiens]
          Length = 618

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 17/40 (42%), Positives = 22/40 (55%), Gaps = 4/40 (10%)

Query: 277 CVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICR 316
           C VC+      + +PC HL +C  CA +LR     CPICR
Sbjct: 571 CKVCMDKEVSVVFIPCGHLVVCQECAPSLR----KCPICR 606


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
           [Homo sapiens]
          Length = 1412

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 81/369 (21%), Positives = 146/369 (39%), Gaps = 53/369 (14%)

Query: 329 RKKLGPLSPTSFNPIISS-QTSDSEE--HPSSENIPPGYEVVSLLEALN-GPLTPSPAVP 384
           RK   P  P    P  +  Q    EE    SSE      E ++ + A    PL  SP V 
Sbjct: 371 RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK 430

Query: 385 PLHVLGDGHL---SGMLPSYGSDGHLPPVRTISPLDRLSDSSSQGL------KLKKSLSK 435
           P   +G G L   +G +P  G  G   P   +   +  S+SSS+        ++  +++ 
Sbjct: 431 PASTMGMGPLGKGAGPVPP-GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAP 489

Query: 436 STSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSC 495
           +  ++   + + +   S ++   Q +   +VQ   E+           + +S + ++SS 
Sbjct: 490 AQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEK----------PMDNSESSEESS- 538

Query: 496 TGTPLSSTISSPEGPASSSLAQSVMSMASSQIS-----TDTVSSMSGSYIAPGTEEEGEA 550
                  +  S E PA+ + AQ+  ++   Q       T+T +S   + +  GT+   +A
Sbjct: 539 ------DSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA 592

Query: 551 LSSPQPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEEDGSPTQEGQRTCAF 610
            ++  PA  +P+  G G    + DS+          +E +D  EE+ G     GQ     
Sbjct: 593 GTATSPAGSSPAVAG-GTQRPAEDSS---------SSEESDSEEEKTGLAVTVGQAKSVG 642

Query: 611 LGMECDNNNDFDIASVKALDNKLCSEVCLPGAWQADDNAVSRNAQRRRLSSSSLEDSETR 670
            G++    +      VK    +  + V LPG  +         A+++  S SS E+S++ 
Sbjct: 643 KGLQVKAAS----VPVKGSLGQGTAPV-LPG--KTGPTVTQVKAEKQEDSESSEEESDSE 695

Query: 671 PCVWGPLAV 679
                P  V
Sbjct: 696 EAAASPAQV 704



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 38/171 (22%), Positives = 60/171 (35%), Gaps = 26/171 (15%)

Query: 438 SQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTG 497
           SQ  +   EE+ E S  ES     + P+ + L            L   +SG   Q     
Sbjct: 251 SQTKAGKPEEDSESSSEESSDSEEETPAAKAL------------LQAKASGKTSQVGAAS 298

Query: 498 TPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQ-- 555
            P     S  +G A +   ++  ++A +Q       S S S  +  +EEE  A + P   
Sbjct: 299 APAKE--SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD-SEEEAPAQAKPSGK 355

Query: 556 ---------PASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEED 597
                    PA  +P +     P        A +  G+Q+ +     EE D
Sbjct: 356 APQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESD 406


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 81/369 (21%), Positives = 146/369 (39%), Gaps = 53/369 (14%)

Query: 329 RKKLGPLSPTSFNPIISS-QTSDSEE--HPSSENIPPGYEVVSLLEALN-GPLTPSPAVP 384
           RK   P  P    P  +  Q    EE    SSE      E ++ + A    PL  SP V 
Sbjct: 448 RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK 507

Query: 385 PLHVLGDGHL---SGMLPSYGSDGHLPPVRTISPLDRLSDSSSQGL------KLKKSLSK 435
           P   +G G L   +G +P  G  G   P   +   +  S+SSS+        ++  +++ 
Sbjct: 508 PASTMGMGPLGKGAGPVPP-GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAP 566

Query: 436 STSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSC 495
           +  ++   + + +   S ++   Q +   +VQ   E+           + +S + ++SS 
Sbjct: 567 AQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEK----------PMDNSESSEESS- 615

Query: 496 TGTPLSSTISSPEGPASSSLAQSVMSMASSQIS-----TDTVSSMSGSYIAPGTEEEGEA 550
                  +  S E PA+ + AQ+  ++   Q       T+T +S   + +  GT+   +A
Sbjct: 616 ------DSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA 669

Query: 551 LSSPQPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEEDGSPTQEGQRTCAF 610
            ++  PA  +P+  G G    + DS+          +E +D  EE+ G     GQ     
Sbjct: 670 GTATSPAGSSPAVAG-GTQRPAEDSS---------SSEESDSEEEKTGLAVTVGQAKSVG 719

Query: 611 LGMECDNNNDFDIASVKALDNKLCSEVCLPGAWQADDNAVSRNAQRRRLSSSSLEDSETR 670
            G++    +      VK    +  + V LPG  +         A+++  S SS E+S++ 
Sbjct: 720 KGLQVKAAS----VPVKGSLGQGTAPV-LPG--KTGPTVTQVKAEKQEDSESSEEESDSE 772

Query: 671 PCVWGPLAV 679
                P  V
Sbjct: 773 EAAASPAQV 781



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 60/303 (19%), Positives = 99/303 (32%), Gaps = 72/303 (23%)

Query: 345 SSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSD 404
           +S +SD  +     ++ P     S +     P   +   P       G +  + P     
Sbjct: 203 TSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP-------GKVGDVTPQV-KG 254

Query: 405 GHLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRP 464
           G LPP +     +  S+SS +G + ++     T            +   SE   Q+    
Sbjct: 255 GALPPAKRAKKPEEESESSEEGSESEEEAPAGT----------RSQVKASEKILQVRAAS 304

Query: 465 SVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSPEG--------PASSSLA 516
           +        G TP         +GA+   +  G P   + SS E         PA+ +L 
Sbjct: 305 APAKGTPGKGATPAPPG----KAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360

Query: 517 QSVMSMASSQISTDTV----SSMSGSYIAP-------------------------GTEEE 547
           Q+  S  +SQ+   +     S   G+  AP                          ++ E
Sbjct: 361 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420

Query: 548 GEALSSPQPASRAPSEEGEGLPA-ESPDSNFAGLP------------AGEQDAEGNDVIE 594
            EA +  +P+ +AP       PA ESP    A  P             G+Q+ +     E
Sbjct: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE 480

Query: 595 EED 597
           E D
Sbjct: 481 ESD 483


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 81/369 (21%), Positives = 146/369 (39%), Gaps = 53/369 (14%)

Query: 329 RKKLGPLSPTSFNPIISS-QTSDSEE--HPSSENIPPGYEVVSLLEALN-GPLTPSPAVP 384
           RK   P  P    P  +  Q    EE    SSE      E ++ + A    PL  SP V 
Sbjct: 448 RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK 507

Query: 385 PLHVLGDGHL---SGMLPSYGSDGHLPPVRTISPLDRLSDSSSQGL------KLKKSLSK 435
           P   +G G L   +G +P  G  G   P   +   +  S+SSS+        ++  +++ 
Sbjct: 508 PASTMGMGPLGKGAGPVPP-GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAP 566

Query: 436 STSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSC 495
           +  ++   + + +   S ++   Q +   +VQ   E+           + +S + ++SS 
Sbjct: 567 AQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEK----------PMDNSESSEESS- 615

Query: 496 TGTPLSSTISSPEGPASSSLAQSVMSMASSQIS-----TDTVSSMSGSYIAPGTEEEGEA 550
                  +  S E PA+ + AQ+  ++   Q       T+T +S   + +  GT+   +A
Sbjct: 616 ------DSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA 669

Query: 551 LSSPQPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEEDGSPTQEGQRTCAF 610
            ++  PA  +P+  G G    + DS+          +E +D  EE+ G     GQ     
Sbjct: 670 GTATSPAGSSPAVAG-GTQRPAEDSS---------SSEESDSEEEKTGLAVTVGQAKSVG 719

Query: 611 LGMECDNNNDFDIASVKALDNKLCSEVCLPGAWQADDNAVSRNAQRRRLSSSSLEDSETR 670
            G++    +      VK    +  + V LPG  +         A+++  S SS E+S++ 
Sbjct: 720 KGLQVKAAS----VPVKGSLGQGTAPV-LPG--KTGPTVTQVKAEKQEDSESSEEESDSE 772

Query: 671 PCVWGPLAV 679
                P  V
Sbjct: 773 EAAASPAQV 781



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 60/303 (19%), Positives = 99/303 (32%), Gaps = 72/303 (23%)

Query: 345 SSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSD 404
           +S +SD  +     ++ P     S +     P   +   P       G +  + P     
Sbjct: 203 TSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP-------GKVGDVTPQV-KG 254

Query: 405 GHLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRP 464
           G LPP +     +  S+SS +G + ++     T            +   SE   Q+    
Sbjct: 255 GALPPAKRAKKPEEESESSEEGSESEEEAPAGT----------RSQVKASEKILQVRAAS 304

Query: 465 SVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSPEG--------PASSSLA 516
           +        G TP         +GA+   +  G P   + SS E         PA+ +L 
Sbjct: 305 APAKGTPGKGATPAPPG----KAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360

Query: 517 QSVMSMASSQISTDTV----SSMSGSYIAP-------------------------GTEEE 547
           Q+  S  +SQ+   +     S   G+  AP                          ++ E
Sbjct: 361 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420

Query: 548 GEALSSPQPASRAPSEEGEGLPA-ESPDSNFAGLP------------AGEQDAEGNDVIE 594
            EA +  +P+ +AP       PA ESP    A  P             G+Q+ +     E
Sbjct: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE 480

Query: 595 EED 597
           E D
Sbjct: 481 ESD 483


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
           [Homo sapiens]
          Length = 1411

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 81/369 (21%), Positives = 146/369 (39%), Gaps = 53/369 (14%)

Query: 329 RKKLGPLSPTSFNPIISS-QTSDSEE--HPSSENIPPGYEVVSLLEALN-GPLTPSPAVP 384
           RK   P  P    P  +  Q    EE    SSE      E ++ + A    PL  SP V 
Sbjct: 371 RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK 430

Query: 385 PLHVLGDGHL---SGMLPSYGSDGHLPPVRTISPLDRLSDSSSQGL------KLKKSLSK 435
           P   +G G L   +G +P  G  G   P   +   +  S+SSS+        ++  +++ 
Sbjct: 431 PASTMGMGPLGKGAGPVPP-GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAP 489

Query: 436 STSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSC 495
           +  ++   + + +   S ++   Q +   +VQ   E+           + +S + ++SS 
Sbjct: 490 AQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEK----------PMDNSESSEESS- 538

Query: 496 TGTPLSSTISSPEGPASSSLAQSVMSMASSQIS-----TDTVSSMSGSYIAPGTEEEGEA 550
                  +  S E PA+ + AQ+  ++   Q       T+T +S   + +  GT+   +A
Sbjct: 539 ------DSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA 592

Query: 551 LSSPQPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEEDGSPTQEGQRTCAF 610
            ++  PA  +P+  G G    + DS+          +E +D  EE+ G     GQ     
Sbjct: 593 GTATSPAGSSPAVAG-GTQRPAEDSS---------SSEESDSEEEKTGLAVTVGQAKSVG 642

Query: 611 LGMECDNNNDFDIASVKALDNKLCSEVCLPGAWQADDNAVSRNAQRRRLSSSSLEDSETR 670
            G++    +      VK    +  + V LPG  +         A+++  S SS E+S++ 
Sbjct: 643 KGLQVKAAS----VPVKGSLGQGTAPV-LPG--KTGPTVTQVKAEKQEDSESSEEESDSE 695

Query: 671 PCVWGPLAV 679
                P  V
Sbjct: 696 EAAASPAQV 704



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 38/171 (22%), Positives = 60/171 (35%), Gaps = 26/171 (15%)

Query: 438 SQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTG 497
           SQ  +   EE+ E S  ES     + P+ + L            L   +SG   Q     
Sbjct: 251 SQTKAGKPEEDSESSSEESSDSEEETPAAKAL------------LQAKASGKTSQVGAAS 298

Query: 498 TPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQ-- 555
            P     S  +G A +   ++  ++A +Q       S S S  +  +EEE  A + P   
Sbjct: 299 APAKE--SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD-SEEEAPAQAKPSGK 355

Query: 556 ---------PASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEED 597
                    PA  +P +     P        A +  G+Q+ +     EE D
Sbjct: 356 APQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESD 406


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 81/369 (21%), Positives = 146/369 (39%), Gaps = 53/369 (14%)

Query: 329 RKKLGPLSPTSFNPIISS-QTSDSEE--HPSSENIPPGYEVVSLLEALN-GPLTPSPAVP 384
           RK   P  P    P  +  Q    EE    SSE      E ++ + A    PL  SP V 
Sbjct: 448 RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVK 507

Query: 385 PLHVLGDGHL---SGMLPSYGSDGHLPPVRTISPLDRLSDSSSQGL------KLKKSLSK 435
           P   +G G L   +G +P  G  G   P   +   +  S+SSS+        ++  +++ 
Sbjct: 508 PASTMGMGPLGKGAGPVPP-GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAP 566

Query: 436 STSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSC 495
           +  ++   + + +   S ++   Q +   +VQ   E+           + +S + ++SS 
Sbjct: 567 AQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEK----------PMDNSESSEESS- 615

Query: 496 TGTPLSSTISSPEGPASSSLAQSVMSMASSQIS-----TDTVSSMSGSYIAPGTEEEGEA 550
                  +  S E PA+ + AQ+  ++   Q       T+T +S   + +  GT+   +A
Sbjct: 616 ------DSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA 669

Query: 551 LSSPQPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEEDGSPTQEGQRTCAF 610
            ++  PA  +P+  G G    + DS+          +E +D  EE+ G     GQ     
Sbjct: 670 GTATSPAGSSPAVAG-GTQRPAEDSS---------SSEESDSEEEKTGLAVTVGQAKSVG 719

Query: 611 LGMECDNNNDFDIASVKALDNKLCSEVCLPGAWQADDNAVSRNAQRRRLSSSSLEDSETR 670
            G++    +      VK    +  + V LPG  +         A+++  S SS E+S++ 
Sbjct: 720 KGLQVKAAS----VPVKGSLGQGTAPV-LPG--KTGPTVTQVKAEKQEDSESSEEESDSE 772

Query: 671 PCVWGPLAV 679
                P  V
Sbjct: 773 EAAASPAQV 781



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 60/303 (19%), Positives = 99/303 (32%), Gaps = 72/303 (23%)

Query: 345 SSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSD 404
           +S +SD  +     ++ P     S +     P   +   P       G +  + P     
Sbjct: 203 TSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP-------GKVGDVTPQV-KG 254

Query: 405 GHLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRP 464
           G LPP +     +  S+SS +G + ++     T            +   SE   Q+    
Sbjct: 255 GALPPAKRAKKPEEESESSEEGSESEEEAPAGT----------RSQVKASEKILQVRAAS 304

Query: 465 SVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSPEG--------PASSSLA 516
           +        G TP         +GA+   +  G P   + SS E         PA+ +L 
Sbjct: 305 APAKGTPGKGATPAPPG----KAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360

Query: 517 QSVMSMASSQISTDTV----SSMSGSYIAP-------------------------GTEEE 547
           Q+  S  +SQ+   +     S   G+  AP                          ++ E
Sbjct: 361 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420

Query: 548 GEALSSPQPASRAPSEEGEGLPA-ESPDSNFAGLP------------AGEQDAEGNDVIE 594
            EA +  +P+ +AP       PA ESP    A  P             G+Q+ +     E
Sbjct: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE 480

Query: 595 EED 597
           E D
Sbjct: 481 ESD 483


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.129    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,687,772
Number of Sequences: 37866
Number of extensions: 1535322
Number of successful extensions: 6942
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 452
Number of HSP's that attempted gapping in prelim test: 6022
Number of HSP's gapped (non-prelim): 1212
length of query: 679
length of database: 18,247,518
effective HSP length: 109
effective length of query: 570
effective length of database: 14,120,124
effective search space: 8048470680
effective search space used: 8048470680
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.