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Search of human proteins with 58530842
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|58530842 desmoplakin isoform II [Homo sapiens]
(2272 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|58530842 desmoplakin isoform II [Homo sapiens] 4481 0.0
gi|58530840 desmoplakin isoform I [Homo sapiens] 2428 0.0
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 964 0.0
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 964 0.0
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 964 0.0
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 964 0.0
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 964 0.0
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 964 0.0
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 964 0.0
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 964 0.0
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 606 e-173
gi|20357504 dystonin isoform 1eB precursor [Homo sapiens] 596 e-170
gi|221316624 dystonin isoform 4 [Homo sapiens] 577 e-164
gi|221316622 dystonin isoform 3 [Homo sapiens] 577 e-164
gi|221316618 dystonin isoform 2 [Homo sapiens] 577 e-164
gi|34577047 dystonin isoform 1 [Homo sapiens] 577 e-164
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 577 e-164
gi|33188445 microfilament and actin filament cross-linker protei... 516 e-145
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 460 e-129
gi|207452735 epiplakin 1 [Homo sapiens] 382 e-105
gi|156104874 envoplakin [Homo sapiens] 243 2e-63
gi|45439327 periplakin [Homo sapiens] 224 1e-57
gi|33188443 microfilament and actin filament cross-linker protei... 132 5e-30
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 106 2e-22
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 103 3e-21
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 103 3e-21
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 103 3e-21
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 103 3e-21
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 102 3e-21
gi|16262452 cingulin [Homo sapiens] 99 5e-20
>gi|58530842 desmoplakin isoform II [Homo sapiens]
Length = 2272
Score = 4481 bits (11623), Expect = 0.0
Identities = 2272/2272 (100%), Positives = 2272/2272 (100%)
Query: 1 MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG 60
MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG
Sbjct: 1 MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG 60
Query: 61 TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI 120
TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI
Sbjct: 61 TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI 120
Query: 121 LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW 180
LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW
Sbjct: 121 LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW 180
Query: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA
Sbjct: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
Query: 241 DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD 300
DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD
Sbjct: 241 DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD 300
Query: 301 KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW 360
KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW
Sbjct: 301 KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW 360
Query: 361 ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE 420
ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE
Sbjct: 361 ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE 420
Query: 421 LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD 480
LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD
Sbjct: 421 LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD 480
Query: 481 ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL 540
ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL
Sbjct: 481 ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL 540
Query: 541 YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF 600
YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF
Sbjct: 541 YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF 600
Query: 601 GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE 660
GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE
Sbjct: 601 GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE 660
Query: 661 NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA 720
NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA
Sbjct: 661 NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA 720
Query: 721 EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT 780
EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT
Sbjct: 721 EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT 780
Query: 781 EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS 840
EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS
Sbjct: 781 EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS 840
Query: 841 QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK 900
QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK
Sbjct: 841 QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK 900
Query: 901 WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD 960
WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD
Sbjct: 901 WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD 960
Query: 961 YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM 1020
YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM
Sbjct: 961 YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM 1020
Query: 1021 LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE 1080
LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE
Sbjct: 1021 LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE 1080
Query: 1081 ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD 1140
ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD
Sbjct: 1081 ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD 1140
Query: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQ 1200
QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQ
Sbjct: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQ 1200
Query: 1201 ESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ 1260
ESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ
Sbjct: 1201 ESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ 1260
Query: 1261 IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED 1320
IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED
Sbjct: 1261 IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED 1320
Query: 1321 STRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQ 1380
STRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQ
Sbjct: 1321 STRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQ 1380
Query: 1381 LYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKL 1440
LYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKL
Sbjct: 1381 LYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKL 1440
Query: 1441 ISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDP 1500
ISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDP
Sbjct: 1441 ISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDP 1500
Query: 1501 FSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLY 1560
FSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLY
Sbjct: 1501 FSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLY 1560
Query: 1561 RSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTV 1620
RSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTV
Sbjct: 1561 RSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTV 1620
Query: 1621 TELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMK 1680
TELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMK
Sbjct: 1621 TELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMK 1680
Query: 1681 IGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGY 1740
IGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGY
Sbjct: 1681 IGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGY 1740
Query: 1741 NDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNE 1800
NDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNE
Sbjct: 1741 NDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNE 1800
Query: 1801 ELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKN 1860
ELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKN
Sbjct: 1801 ELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKN 1860
Query: 1861 TLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVL 1920
TLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVL
Sbjct: 1861 TLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVL 1920
Query: 1921 VDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSD 1980
VDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSD
Sbjct: 1921 VDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSD 1980
Query: 1981 DVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIER 2040
DVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIER
Sbjct: 1981 DVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIER 2040
Query: 2041 GIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFE 2100
GIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFE
Sbjct: 2041 GIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFE 2100
Query: 2101 GVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGR 2160
GVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGR
Sbjct: 2101 GVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGR 2160
Query: 2161 AAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNM 2220
AAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNM
Sbjct: 2161 AAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNM 2220
Query: 2221 SSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH 2272
SSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH
Sbjct: 2221 SSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH 2272
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 2428 bits (6293), Expect = 0.0
Identities = 1238/1376 (89%), Positives = 1272/1376 (92%), Gaps = 41/1376 (2%)
Query: 1 MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG 60
MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG
Sbjct: 1 MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG 60
Query: 61 TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI 120
TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI
Sbjct: 61 TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI 120
Query: 121 LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW 180
LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW
Sbjct: 121 LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW 180
Query: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA
Sbjct: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
Query: 241 DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD 300
DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD
Sbjct: 241 DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD 300
Query: 301 KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW 360
KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW
Sbjct: 301 KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW 360
Query: 361 ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE 420
ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE
Sbjct: 361 ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE 420
Query: 421 LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD 480
LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD
Sbjct: 421 LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD 480
Query: 481 ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL 540
ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL
Sbjct: 481 ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL 540
Query: 541 YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF 600
YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF
Sbjct: 541 YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF 600
Query: 601 GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE 660
GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE
Sbjct: 601 GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE 660
Query: 661 NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA 720
NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA
Sbjct: 661 NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA 720
Query: 721 EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT 780
EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT
Sbjct: 721 EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT 780
Query: 781 EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS 840
EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS
Sbjct: 781 EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS 840
Query: 841 QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK 900
QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK
Sbjct: 841 QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK 900
Query: 901 WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD 960
WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD
Sbjct: 901 WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD 960
Query: 961 YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM 1020
YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM
Sbjct: 961 YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM 1020
Query: 1021 LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE 1080
LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE
Sbjct: 1021 LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE 1080
Query: 1081 ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD 1140
ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD
Sbjct: 1081 ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD 1140
Query: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQ 1200
QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAK N
Sbjct: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN 1200
Query: 1201 ES----KNQCTQVVQERESLLVKIKVLEQDKA--------RLQR----LEDELNRAKSTL 1244
E +N+ + ++ + +I + ++D + RL R L+DE+ R ++
Sbjct: 1201 EEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSI 1260
Query: 1245 EAETRVKQRLE--------C------EKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSE 1290
T ++R E C +KQ ++ +L Q Q S ++ E K+
Sbjct: 1261 LQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI 1320
Query: 1291 REKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1346
++KN EIERL+AE + EE RR E +++L R+ Y EI L+ +
Sbjct: 1321 QDKN---KEIERLKAEFQ--EEAKRR------WEYENELSKVRNNYDEEIISLKNQ 1365
Score = 2132 bits (5523), Expect = 0.0
Identities = 1147/1473 (77%), Positives = 1245/1473 (84%), Gaps = 21/1473 (1%)
Query: 811 LKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRI 870
+K++KN L L ++ ++Q+ + S+ SQ+ +++L + + T+ + R+++
Sbjct: 1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQS 1468
Query: 871 DKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQ 930
+ D K+I++L+ D K L D R ++ +++ +N+
Sbjct: 1469 LDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKL 1528
Query: 931 KNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSG 990
K E++ R E V + ++KD ++ T +L + +++ ++
Sbjct: 1529 KVQEQELTRLRIDYERVSQ-----ERTVKDQDI-----TRFQNSLKELQLQKQKVEEELN 1578
Query: 991 VILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVL----EEELRLARD 1046
+ + A++ + +L R L E + +L + + ++ E++LR RD
Sbjct: 1579 RLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRD 1638
Query: 1047 ANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKE 1106
+ + + + L++ +E + +L +E +QA L + ++ ++ + E
Sbjct: 1639 VLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNE 1698
Query: 1107 LNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQ--CEKENLGWQKLESEKAI 1164
+I RL E+ + +E+ + +YD L++ R +N +L S+ I
Sbjct: 1699 SKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQI 1758
Query: 1165 KE-KEYEIERLRVLLQEEGTRKRE----YENELAKASNRIQESKNQCTQVVQERESLLVK 1219
+ E++ L LQ E R+ ++ + +ASNRIQESKNQCTQVVQERESLLVK
Sbjct: 1759 SNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVK 1818
Query: 1220 IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1279
IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI
Sbjct: 1819 IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878
Query: 1280 RKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE 1339
RKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE
Sbjct: 1879 RKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE 1938
Query: 1340 IDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGK 1399
IDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGK
Sbjct: 1939 IDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGK 1998
Query: 1400 KSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGI 1459
KSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGI
Sbjct: 1999 KSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGI 2058
Query: 1460 IDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDR 1519
IDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDR
Sbjct: 2059 IDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDR 2118
Query: 1520 ETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTK 1579
ETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTK
Sbjct: 2119 ETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTK 2178
Query: 1580 KKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELES 1639
KKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELES
Sbjct: 2179 KKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELES 2238
Query: 1640 GQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAAT 1699
GQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAAT
Sbjct: 2239 GQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAAT 2298
Query: 1700 GFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKEL 1759
GFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKEL
Sbjct: 2299 GFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKEL 2358
Query: 1760 IEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDP 1819
IEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDP
Sbjct: 2359 IEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDP 2418
Query: 1820 NTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMS 1879
NTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMS
Sbjct: 2419 NTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMS 2478
Query: 1880 VQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGL 1939
VQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGL
Sbjct: 2479 VQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGL 2538
Query: 1940 VDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISS 1999
VDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISS
Sbjct: 2539 VDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISS 2598
Query: 2000 VRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTG 2059
VRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTG
Sbjct: 2599 VRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTG 2658
Query: 2060 GIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWL 2119
GIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWL
Sbjct: 2659 GIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWL 2718
Query: 2120 PYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPK 2179
PYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPK
Sbjct: 2719 PYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPK 2778
Query: 2180 TKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSR 2239
TKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSR
Sbjct: 2779 TKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSR 2838
Query: 2240 SGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH 2272
SGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH
Sbjct: 2839 SGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH 2871
Score = 90.5 bits (223), Expect = 2e-17
Identities = 130/638 (20%), Positives = 260/638 (40%), Gaps = 127/638 (19%)
Query: 813 KIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDK 872
K DL LK + + ++ EL+ A+ +S+ + D +L K+ + +Q + +++
Sbjct: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
Query: 873 -----QIDFRL--WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
++D + +L+K Q++ + + D KRR+ S+E +F
Sbjct: 1082 LKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVED-RFDQQKNDYD 1140
Query: 926 FLNEQKNLHSEISGK---------RDKSEEVQKIAELCANS---IKDYELQLAS----YT 969
L + + E G ++K E++++ L ++YE +LA Y
Sbjct: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN 1200
Query: 970 SGLETLLN-----IPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSL 1024
+ L N I I +T I+ I + D L R R L + + L
Sbjct: 1201 EEMSNLRNKYETEINITKTTIKE----ISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRL 1256
Query: 1025 EDLKLKNTKIEVLEEELRLARDA-NSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELK 1083
D L+ T+ EE L + A SE K + L+ L+++
Sbjct: 1257 NDSILQATEQRRRAEENALQQKACGSEIMQKKQHLE-----------------IELKQVM 1299
Query: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQL- 1142
+Q D KQ+L++ I++ N++I RL E ++E +RR E+ + +N+YD+
Sbjct: 1300 QQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEI 1359
Query: 1143 -------------------QKARQCEKENLGWQK-----------------------LES 1160
Q Q E++ G++ ++
Sbjct: 1360 ISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQT 1419
Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN-------RIQESKNQCTQVVQER 1213
+ ++ E +I++ + E RK++ E EL + + R ++S + + +Q++
Sbjct: 1420 TENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDK 1479
Query: 1214 ESLLVKIK-----------VLEQDKARLQRLEDELNRAKST-------LEAETRVKQRLE 1255
+ ++K LE + ARLQR++ +L +A S+ L+ + + RL
Sbjct: 1480 NKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLR 1539
Query: 1256 CEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER-- 1313
+ +++ + +R + ++++++ +++K E E N L+ + K++EE
Sbjct: 1540 IDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELE 1599
Query: 1314 -CRRKLEDS----TRETQSQLETERSRYQREIDKLRQR 1346
RR L++ T TQ QLE +R D LRQ+
Sbjct: 1600 GMRRSLKEQAIKITNLTQ-QLEQASIVKKRSEDDLRQQ 1636
Score = 38.9 bits (89), Expect = 0.058
Identities = 28/102 (27%), Positives = 55/102 (53%), Gaps = 11/102 (10%)
Query: 245 KSAIYQLEEEYENLL---------KASFERM-DHLRQLQNIIQATSREIMWINDCEEEEL 294
K+ Q+ +E E+LL KA +R+ D L + ++ ++A +R + +CE++++
Sbjct: 1802 KNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-ECEKQQI 1860
Query: 295 LYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQL 336
D + T ++K+EA S+ E E+E N L+ E ++L
Sbjct: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERL 1902
Score = 35.0 bits (79), Expect = 0.84
Identities = 64/362 (17%), Positives = 138/362 (38%), Gaps = 59/362 (16%)
Query: 100 QLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVP 159
QLT +E D +A +D+L RE R + + + L Q E +R + + I
Sbjct: 1379 QLTMQKEEDTSGYRAQ-----IDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQ-- 1431
Query: 160 RVRRASSKGGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGV-----DLASV 214
K G Q + + VT + + +D A + ++ +
Sbjct: 1432 -----QQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERL 1486
Query: 215 EQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQN 274
+Q I+ + D +L +++ DL++ ++ E N LK + + LR
Sbjct: 1487 KQLIDKETNDRKCLEDENARLQRVQYDLQKANSS---ATETINKLKVQEQELTRLR---- 1539
Query: 275 IIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESD 334
+ E + + + K+ +I + Q + Q + E+ELN+LK+ +
Sbjct: 1540 --------------IDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTAS 1585
Query: 335 QLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKG 394
+ + +++E +L+ Q I +T ++ + K
Sbjct: 1586 EDSCKRKKLEEELEGMRRSLKEQAIKITNLT-----------------QQLEQASIVKKR 1628
Query: 395 LQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPD 454
+D +R++ +++ HL E+ + E+ R E + + L+ + + + Q RN
Sbjct: 1629 SEDDLRQQ----RDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684
Query: 455 YR 456
++
Sbjct: 1685 FQ 1686
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 964 bits (2491), Expect = 0.0
Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)
Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
+D +R+++TA L+E ++I T + L +G +S+ E A +L G GS+AG
Sbjct: 3640 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3699
Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
++ S+ +A +K L+S E +LLEAQAATG ++DP + E+LTVD A+ + L+ +
Sbjct: 3700 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3759
Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
++ +AE+A+TG+ DP++ +T+S+ +A+KK LI E +RLL+AQ+A+GG+VDP LP
Sbjct: 3760 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3819
Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
+VA RG +++D + L++P + +++VDP T +++SY QL RCR + TG LLL +
Sbjct: 3820 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3878
Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
R ++F+G+R+ +T+ ELV S ++ +T +L G S +EV + ++ FL+G+SCIAG+
Sbjct: 3879 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3938
Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
+ + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+ L+L VEEA + G+VG
Sbjct: 3939 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3998
Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 3999 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4058
Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4059 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4118
Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4119 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4178
Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
EEITI+ SDG + +++DR++G QYDI DAI K L+DR DQYR+G+LS+T+FADM+S
Sbjct: 4179 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4238
Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
G S S G SSS + +S + +S+SD EE+ P+A I
Sbjct: 4239 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4284
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++ + DAV++G++D+
Sbjct: 4285 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4344
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
M R+ AQKAF GFE + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+ G
Sbjct: 4345 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4404
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ +EA+++G +D R AQ+L+D +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4405 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4464
Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
EAA+ S+KG SPY++S SGS +GSR+GSR+GSR+GSRRGSFDATG+ +S +
Sbjct: 4465 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4516
Query: 2265 FSSSS 2269
FSSSS
Sbjct: 4517 FSSSS 4521
Score = 597 bits (1538), Expect = e-170
Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)
Query: 78 CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
C + L +A+ ++Q +++ G R+ E++ +A+ + +L + ++ ++ P
Sbjct: 408 CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 467
Query: 136 DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
+ +R+ +L E++ A L ++ P + A + Q ++ T
Sbjct: 468 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 524
Query: 188 TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
+ L W+ + + +D WGVDL SVE + SHRG+H SI ++R ++++ ++D + S
Sbjct: 525 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 584
Query: 247 --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
+ +L+ +Y LL +S R+ L L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 585 ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 644
Query: 299 SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
SD+NTN+ K+E++S M +LE+KEK++ +L+ D+L+ HPA +E++ LQTQW
Sbjct: 645 SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 704
Query: 359 SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
SW+LQ+ CI+ HLKENAAYFQFF + + E L+ LQ+++R+KY CD++ + L + +
Sbjct: 705 SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 764
Query: 419 KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
++ + E+E++ EYK + L ++K +VQLKPR+P + + L A+CDYKQ + VHK
Sbjct: 765 QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 824
Query: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
GDEC L + S W V G + VPSV ++PPPN A + ++E ++A++ LW+
Sbjct: 825 GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 884
Query: 539 QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
QL+++MKSL++W D++ IR+ ++A +T++ E+ + + LELHYQ F+R+SQ +
Sbjct: 885 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 944
Query: 599 MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
FG +D+ + ++ HYQ L+ L Q ++ CQ
Sbjct: 945 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 984
Query: 659 RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
+ EL+ IR Q+E CE R + LPL D+ + +I E + Q +
Sbjct: 985 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1034
Query: 716 --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
+ +A + + + +LA S L++E+ KLE + ++ YL L T+ +
Sbjct: 1035 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094
Query: 774 LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
++ E++L+ +E +L E + V L ++EA + LKK++ ++ ++ EL+
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154
Query: 834 KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
AQ++ + Q++ D+++ ++ E+V QL +RWQ + Q D R +LE+ +QLR YR+
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1214
Query: 894 NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
+ WL DA+RRQ+ +++M DS V L +++ L EI +K EE Q+ A+
Sbjct: 1215 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1274
Query: 954 CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
N+IKDYELQL +Y + LE + + P K+ +QS S ++QE D+ Y EL T + Y
Sbjct: 1275 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333
Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
+F+SE L+ +E+ + + + + EE RLA + + + + + + Q K QAE
Sbjct: 1334 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1391
Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
+ + EE+ R +A +D + K+++ + Q+++ +E +I + E +R R +E
Sbjct: 1392 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451
Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
+ + + ++ R + E + L + E+E ++ + E ERLR +Q+E RKR
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1511
Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
+ E ELA E+ + + +Q E L ++ + E+ + R ++++ L A+
Sbjct: 1512 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571
Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
+ EAE + K+ EK Q++ L + ++ +EEA R+ + + E +ER + E
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1630
Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
+ER Q + + E + +++ +Q E E+ + + E + R+ Q E
Sbjct: 1631 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690
Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
E ++ + + +G ++ A + +L +T +G++ + + E+ R A +
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1745
Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
+ + + V A+ + L+ + E + LEA+A R
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1797
Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
+L ++A R L + RQ+ A E A
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDA 1824
Score = 528 bits (1359), Expect = e-149
Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)
Query: 997 ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
A + A L+ R D RFL E + ++ + + ++ V +E R E+ +
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
+ L + + K + + Q +L A E L++Q EL + A++ + ++L E+
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2364
Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
+E E++R+ + ++ K ++ +A+ + + E +G + +E A
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424
Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
+EK ++ L + Q+ + R RE EL + ++Q+ K++ Q VQ
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2484
Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
E++SLL + + +EQ+KA+L++L +DE+ +A+ E + R +Q++E E
Sbjct: 2485 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2544
Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
+Q++ + + + + EE +R+ + E ++ E+++ L E +RL+ +++ +EE+
Sbjct: 2545 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
R L S T SQ+ ++ + R G E + E FDGLR
Sbjct: 2605 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2650
Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
+KV+A +L E ++ L +L +G +V+E+A +++ +L+G SIAG + EK
Sbjct: 2651 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2710
Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
S+ A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+ ++ + ++ +A
Sbjct: 2711 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2770
Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S +P DVA
Sbjct: 2771 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2830
Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
RG D ++ R L DP D K F DP T + ++Y+QL ERC +P TGL LL +
Sbjct: 2831 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2890
Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
+K ++S FQG + VT+ E+++S R + + +G
Sbjct: 2891 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2948
Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
+I+ +++ + I ++ G C G +Y + + + +
Sbjct: 2949 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 3008
Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
+ ++ VR A+ LLEAQA TG I+
Sbjct: 3009 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3068
Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG +SLFQA+ K LI +
Sbjct: 3069 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3128
Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
G+RLL+AQ++TGGI+DP +SHR+P+D+A RG +EE S LS P D K + DP+T E
Sbjct: 3129 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3188
Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
TY +L++RC D+ TGL LLPL EK + + E E+ +E
Sbjct: 3189 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3233
Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
++K ++ WE I+ R L+ + + ++ I + +
Sbjct: 3234 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3293
Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
+ R LS + L+ V S + SGV S F + +V +S + SV
Sbjct: 3294 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3347
Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
R L L+ S +A I+ + EK+SI E + RG++ + T LLEAQA TG
Sbjct: 3348 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3397
Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
++ P Q+L + +AV GV+ ++ +L A+KA G+ +S +A+++ +
Sbjct: 3398 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3457
Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
+ G R LE Q TGG++DP R+ + A ++G+ + L D S K P T
Sbjct: 3458 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3517
Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
++Y+ + R + + TGLRLL
Sbjct: 3518 HENLTYRQLLERCVEDPETGLRLL 3541
Score = 419 bits (1078), Expect = e-116
Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)
Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
+Q ++ L Q++T E+ I+ I + E+ E++ + L + +E R
Sbjct: 2936 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2991
Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
RE QL+ ERS R E+D +R+ G++ E +++ L+K +
Sbjct: 2992 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3048
Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
A+ L E Q +D + +V+E V E L A P
Sbjct: 3049 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3108
Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
+ SL +A +K LI E + LL+AQ +TGGI+DP ++ ++ +D A AR +D +
Sbjct: 3109 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3168
Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
+ + A + DP +G+ + E ++ D+ TG+ LL L
Sbjct: 3169 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3212
Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
+ A AR +LY L +K V+ PV K V + E
Sbjct: 3213 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3269
Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
+ +E +L+ V++ +SF G+R PV +EL+ SG+L +
Sbjct: 3270 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3329
Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
+L+ G+ + ++ E ++ LQGS C+AGIY E TK+K+ IYEAM+ GL+R TA LL
Sbjct: 3330 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3389
Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
EAQAATGF+VDPV N RL V EA K G+VG E E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3390 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3449
Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
AM K L+ + HGIRLLEAQIATGGIIDP SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3450 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3509
Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
KGFFDPNT ENLTY QL ERC++D ETGL LLPLK EK + V+T+Q T + R +
Sbjct: 3510 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3569
Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
+ + MS+ E + LI E +L +++ +T R++++
Sbjct: 3570 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3621
Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
I + I+K + R + G S ++ ++D+
Sbjct: 3622 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3652
Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
F ++I ++ + L + S + LE S +A ++ + + +S
Sbjct: 3653 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3705
Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
I + +++G++ + + LLEAQA TG ++ P G++L++ +AV +G++ ++ RL A+
Sbjct: 3706 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3765
Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
+A G+ ++ +S +A+K++ +P E R L+ Q TGG+VDP + + E A +
Sbjct: 3766 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3825
Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
+G+++ +L + S + P T ++SY + R +D TG L L +A ++
Sbjct: 3826 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3884
Query: 2211 SKGLPSPYNM 2220
+GL M
Sbjct: 3885 FRGLRKQITM 3894
Score = 372 bits (956), Expect = e-102
Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)
Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
SF G+R+ V+ L ++GIL + L G + DE+ R ++ +LQG S IAG+ +
Sbjct: 2645 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2704
Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
T +KL +Y A++ L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E
Sbjct: 2705 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2764
Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
KLLSAERAVTGY DP TG ISLFQAM K LI + HGIRLLEAQIATGG+IDP SHR+
Sbjct: 2765 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2824
Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2825 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2884
Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
+K + +V D E ++ ++K + K + WE I
Sbjct: 2885 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2928
Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
R L+ + + ++ I ++ +Q + G L L++
Sbjct: 2929 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 2980
Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
V + + S V D +++ + SV ++ + +VR L ++ IA ++
Sbjct: 2981 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3030
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
E +K+SI +++ ++ S LLEAQA TG II P T +L++ +AV G++ +
Sbjct: 3031 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3090
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
+L A+KA G+ + +S +A+K+ +P E G R L+ Q TGG+VDP
Sbjct: 3091 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3150
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ + A +G +D ++ L + AK + P T +Y + R + +TGL LL
Sbjct: 3151 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3210
Query: 2205 EAASVSSK 2212
+ +++
Sbjct: 3211 PLSEKAAR 3218
Score = 259 bits (663), Expect = 2e-68
Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)
Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
D KL F GLRK++T +L Q++D+ T +L +G S+EEV +Q FL G IAG
Sbjct: 3879 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3938
Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
+ KE+ S+ +A +K +I P + LLEAQAATG +IDP + KLTV+ A+ ++
Sbjct: 3939 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3998
Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
+ + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP S
Sbjct: 3999 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4058
Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
LP +VA RGL D ++ L DP D K F DP T++ ++Y+QL ERC +P TGL L
Sbjct: 4059 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4118
Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
L + ++++ S +R + ++V E G++ T EL + +
Sbjct: 4119 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4178
Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
+E+ D + S I + + ++ I +A+ L+ R GT +
Sbjct: 4179 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4234
Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
+L A GF S+ P+ A R + V G D ET
Sbjct: 4235 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4291
Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
+S+ +AM++ L++ G RLLEAQ TGGIIDP R PV A +G ++ + + ++
Sbjct: 4292 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4351
Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
GF DP T+ ++ Q ++ E G L + Q T
Sbjct: 4352 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4396
Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
+++P+T + + EA ++G +D T ++L + G+ L KT +
Sbjct: 4397 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4443
Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
+DA+D+ +V+ + + T+ +G G+++ +G + SR
Sbjct: 4444 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4503
Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
S S ++T SSS+S +
Sbjct: 4504 GS---FDATGSGFSMTFSSSSYSSS 4525
Score = 111 bits (278), Expect = 7e-24
Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)
Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
E+++ + + + ++LEEEL RL R+A + K + L+ L K +AE A A
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1772
Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
EE R + +KQ L+ G+ +EL E+ RL E+ KR+R+ E+ +Q+
Sbjct: 1773 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1829
Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
+ +++ + K E+E A+KEKE E ERLR L ++E ++R E + A+
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889
Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
I+E + Q+ + +S L + K L +D R +R LE
Sbjct: 1890 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946
Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
EL R +S E R K++ E E + + + + + EE ++K + E++ R++ +
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006
Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
E+ERL+A++ E RR E + +E+ QL+ + Q+ + + + ++ +
Sbjct: 2007 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062
Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
E + T+ + V D LR + A
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEA 2085
Score = 99.8 bits (247), Expect = 3e-20
Identities = 62/210 (29%), Positives = 109/210 (51%)
Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
L+ S IA + EK+S+ ++R ++ T LLEAQA +G ++ P ++L++
Sbjct: 2692 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2751
Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
+AV +GV+ ++ +L A++A G++ +++S +A+++ + E G R LE Q
Sbjct: 2752 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2811
Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
TGG++DP R+ + A R+G+ D + L D S K P T ++Y + R
Sbjct: 2812 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2871
Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
+ + TGL LL ++KG Y S A
Sbjct: 2872 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2901
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 964 bits (2491), Expect = 0.0
Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)
Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
+D +R+++TA L+E ++I T + L +G +S+ E A +L G GS+AG
Sbjct: 3644 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3703
Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
++ S+ +A +K L+S E +LLEAQAATG ++DP + E+LTVD A+ + L+ +
Sbjct: 3704 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3763
Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
++ +AE+A+TG+ DP++ +T+S+ +A+KK LI E +RLL+AQ+A+GG+VDP LP
Sbjct: 3764 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3823
Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
+VA RG +++D + L++P + +++VDP T +++SY QL RCR + TG LLL +
Sbjct: 3824 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3882
Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
R ++F+G+R+ +T+ ELV S ++ +T +L G S +EV + ++ FL+G+SCIAG+
Sbjct: 3883 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3942
Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
+ + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+ L+L VEEA + G+VG
Sbjct: 3943 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4002
Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 4003 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4062
Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4063 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4122
Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4123 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4182
Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
EEITI+ SDG + +++DR++G QYDI DAI K L+DR DQYR+G+LS+T+FADM+S
Sbjct: 4183 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4242
Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
G S S G SSS + +S + +S+SD EE+ P+A I
Sbjct: 4243 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4288
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++ + DAV++G++D+
Sbjct: 4289 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4348
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
M R+ AQKAF GFE + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+ G
Sbjct: 4349 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4408
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ +EA+++G +D R AQ+L+D +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4409 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4468
Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
EAA+ S+KG SPY++S SGS +GSR+GSR+GSR+GSRRGSFDATG+ +S +
Sbjct: 4469 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4520
Query: 2265 FSSSS 2269
FSSSS
Sbjct: 4521 FSSSS 4525
Score = 597 bits (1538), Expect = e-170
Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)
Query: 78 CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
C + L +A+ ++Q +++ G R+ E++ +A+ + +L + ++ ++ P
Sbjct: 412 CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 471
Query: 136 DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
+ +R+ +L E++ A L ++ P + A + Q ++ T
Sbjct: 472 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 528
Query: 188 TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
+ L W+ + + +D WGVDL SVE + SHRG+H SI ++R ++++ ++D + S
Sbjct: 529 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 588
Query: 247 --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
+ +L+ +Y LL +S R+ L L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 589 ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 648
Query: 299 SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
SD+NTN+ K+E++S M +LE+KEK++ +L+ D+L+ HPA +E++ LQTQW
Sbjct: 649 SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 708
Query: 359 SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
SW+LQ+ CI+ HLKENAAYFQFF + + E L+ LQ+++R+KY CD++ + L + +
Sbjct: 709 SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 768
Query: 419 KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
++ + E+E++ EYK + L ++K +VQLKPR+P + + L A+CDYKQ + VHK
Sbjct: 769 QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 828
Query: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
GDEC L + S W V G + VPSV ++PPPN A + ++E ++A++ LW+
Sbjct: 829 GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 888
Query: 539 QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
QL+++MKSL++W D++ IR+ ++A +T++ E+ + + LELHYQ F+R+SQ +
Sbjct: 889 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 948
Query: 599 MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
FG +D+ + ++ HYQ L+ L Q ++ CQ
Sbjct: 949 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 988
Query: 659 RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
+ EL+ IR Q+E CE R + LPL D+ + +I E + Q +
Sbjct: 989 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1038
Query: 716 --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
+ +A + + + +LA S L++E+ KLE + ++ YL L T+ +
Sbjct: 1039 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1098
Query: 774 LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
++ E++L+ +E +L E + V L ++EA + LKK++ ++ ++ EL+
Sbjct: 1099 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1158
Query: 834 KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
AQ++ + Q++ D+++ ++ E+V QL +RWQ + Q D R +LE+ +QLR YR+
Sbjct: 1159 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1218
Query: 894 NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
+ WL DA+RRQ+ +++M DS V L +++ L EI +K EE Q+ A+
Sbjct: 1219 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1278
Query: 954 CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
N+IKDYELQL +Y + LE + + P K+ +QS S ++QE D+ Y EL T + Y
Sbjct: 1279 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1337
Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
+F+SE L+ +E+ + + + + EE RLA + + + + + + Q K QAE
Sbjct: 1338 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1395
Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
+ + EE+ R +A +D + K+++ + Q+++ +E +I + E +R R +E
Sbjct: 1396 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1455
Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
+ + + ++ R + E + L + E+E ++ + E ERLR +Q+E RKR
Sbjct: 1456 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1515
Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
+ E ELA E+ + + +Q E L ++ + E+ + R ++++ L A+
Sbjct: 1516 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1575
Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
+ EAE + K+ EK Q++ L + ++ +EEA R+ + + E +ER + E
Sbjct: 1576 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1634
Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
+ER Q + + E + +++ +Q E E+ + + E + R+ Q E
Sbjct: 1635 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1694
Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
E ++ + + +G ++ A + +L +T +G++ + + E+ R A +
Sbjct: 1695 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1749
Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
+ + + V A+ + L+ + E + LEA+A R
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1801
Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
+L ++A R L + RQ+ A E A
Sbjct: 1802 ELAEEAARLRALAEEAKRQRQLAEEDA 1828
Score = 528 bits (1359), Expect = e-149
Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)
Query: 997 ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
A + A L+ R D RFL E + ++ + + ++ V +E R E+ +
Sbjct: 2249 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2308
Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
+ L + + K + + Q +L A E L++Q EL + A++ + ++L E+
Sbjct: 2309 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2368
Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
+E E++R+ + ++ K ++ +A+ + + E +G + +E A
Sbjct: 2369 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2428
Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
+EK ++ L + Q+ + R RE EL + ++Q+ K++ Q VQ
Sbjct: 2429 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2488
Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
E++SLL + + +EQ+KA+L++L +DE+ +A+ E + R +Q++E E
Sbjct: 2489 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2548
Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
+Q++ + + + + EE +R+ + E ++ E+++ L E +RL+ +++ +EE+
Sbjct: 2549 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
R L S T SQ+ ++ + R G E + E FDGLR
Sbjct: 2609 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2654
Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
+KV+A +L E ++ L +L +G +V+E+A +++ +L+G SIAG + EK
Sbjct: 2655 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2714
Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
S+ A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+ ++ + ++ +A
Sbjct: 2715 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2774
Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S +P DVA
Sbjct: 2775 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2834
Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
RG D ++ R L DP D K F DP T + ++Y+QL ERC +P TGL LL +
Sbjct: 2835 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2894
Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
+K ++S FQG + VT+ E+++S R + + +G
Sbjct: 2895 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2952
Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
+I+ +++ + I ++ G C G +Y + + + +
Sbjct: 2953 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 3012
Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
+ ++ VR A+ LLEAQA TG I+
Sbjct: 3013 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3072
Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG +SLFQA+ K LI +
Sbjct: 3073 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3132
Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
G+RLL+AQ++TGGI+DP +SHR+P+D+A RG +EE S LS P D K + DP+T E
Sbjct: 3133 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3192
Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
TY +L++RC D+ TGL LLPL EK + + E E+ +E
Sbjct: 3193 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3237
Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
++K ++ WE I+ R L+ + + ++ I + +
Sbjct: 3238 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3297
Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
+ R LS + L+ V S + SGV S F + +V +S + SV
Sbjct: 3298 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3351
Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
R L L+ S +A I+ + EK+SI E + RG++ + T LLEAQA TG
Sbjct: 3352 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3401
Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
++ P Q+L + +AV GV+ ++ +L A+KA G+ +S +A+++ +
Sbjct: 3402 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3461
Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
+ G R LE Q TGG++DP R+ + A ++G+ + L D S K P T
Sbjct: 3462 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3521
Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
++Y+ + R + + TGLRLL
Sbjct: 3522 HENLTYRQLLERCVEDPETGLRLL 3545
Score = 419 bits (1078), Expect = e-116
Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)
Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
+Q ++ L Q++T E+ I+ I + E+ E++ + L + +E R
Sbjct: 2940 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2995
Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
RE QL+ ERS R E+D +R+ G++ E +++ L+K +
Sbjct: 2996 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3052
Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
A+ L E Q +D + +V+E V E L A P
Sbjct: 3053 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3112
Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
+ SL +A +K LI E + LL+AQ +TGGI+DP ++ ++ +D A AR +D +
Sbjct: 3113 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3172
Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
+ + A + DP +G+ + E ++ D+ TG+ LL L
Sbjct: 3173 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3216
Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
+ A AR +LY L +K V+ PV K V + E
Sbjct: 3217 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3273
Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
+ +E +L+ V++ +SF G+R PV +EL+ SG+L +
Sbjct: 3274 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3333
Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
+L+ G+ + ++ E ++ LQGS C+AGIY E TK+K+ IYEAM+ GL+R TA LL
Sbjct: 3334 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3393
Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
EAQAATGF+VDPV N RL V EA K G+VG E E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3394 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3453
Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
AM K L+ + HGIRLLEAQIATGGIIDP SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3454 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3513
Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
KGFFDPNT ENLTY QL ERC++D ETGL LLPLK EK + V+T+Q T + R +
Sbjct: 3514 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3573
Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
+ + MS+ E + LI E +L +++ +T R++++
Sbjct: 3574 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3625
Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
I + I+K + R + G S ++ ++D+
Sbjct: 3626 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3656
Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
F ++I ++ + L + S + LE S +A ++ + + +S
Sbjct: 3657 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3709
Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
I + +++G++ + + LLEAQA TG ++ P G++L++ +AV +G++ ++ RL A+
Sbjct: 3710 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3769
Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
+A G+ ++ +S +A+K++ +P E R L+ Q TGG+VDP + + E A +
Sbjct: 3770 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3829
Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
+G+++ +L + S + P T ++SY + R +D TG L L +A ++
Sbjct: 3830 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3888
Query: 2211 SKGLPSPYNM 2220
+GL M
Sbjct: 3889 FRGLRKQITM 3898
Score = 372 bits (956), Expect = e-102
Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)
Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
SF G+R+ V+ L ++GIL + L G + DE+ R ++ +LQG S IAG+ +
Sbjct: 2649 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2708
Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
T +KL +Y A++ L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E
Sbjct: 2709 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2768
Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
KLLSAERAVTGY DP TG ISLFQAM K LI + HGIRLLEAQIATGG+IDP SHR+
Sbjct: 2769 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2828
Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2829 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2888
Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
+K + +V D E ++ ++K + K + WE I
Sbjct: 2889 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2932
Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
R L+ + + ++ I ++ +Q + G L L++
Sbjct: 2933 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 2984
Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
V + + S V D +++ + SV ++ + +VR L ++ IA ++
Sbjct: 2985 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3034
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
E +K+SI +++ ++ S LLEAQA TG II P T +L++ +AV G++ +
Sbjct: 3035 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3094
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
+L A+KA G+ + +S +A+K+ +P E G R L+ Q TGG+VDP
Sbjct: 3095 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3154
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ + A +G +D ++ L + AK + P T +Y + R + +TGL LL
Sbjct: 3155 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3214
Query: 2205 EAASVSSK 2212
+ +++
Sbjct: 3215 PLSEKAAR 3222
Score = 259 bits (663), Expect = 2e-68
Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)
Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
D KL F GLRK++T +L Q++D+ T +L +G S+EEV +Q FL G IAG
Sbjct: 3883 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3942
Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
+ KE+ S+ +A +K +I P + LLEAQAATG +IDP + KLTV+ A+ ++
Sbjct: 3943 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4002
Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
+ + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP S
Sbjct: 4003 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4062
Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
LP +VA RGL D ++ L DP D K F DP T++ ++Y+QL ERC +P TGL L
Sbjct: 4063 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4122
Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
L + ++++ S +R + ++V E G++ T EL + +
Sbjct: 4123 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4182
Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
+E+ D + S I + + ++ I +A+ L+ R GT +
Sbjct: 4183 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4238
Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
+L A GF S+ P+ A R + V G D ET
Sbjct: 4239 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4295
Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
+S+ +AM++ L++ G RLLEAQ TGGIIDP R PV A +G ++ + + ++
Sbjct: 4296 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4355
Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
GF DP T+ ++ Q ++ E G L + Q T
Sbjct: 4356 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4400
Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
+++P+T + + EA ++G +D T ++L + G+ L KT +
Sbjct: 4401 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4447
Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
+DA+D+ +V+ + + T+ +G G+++ +G + SR
Sbjct: 4448 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4507
Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
S S ++T SSS+S +
Sbjct: 4508 GS---FDATGSGFSMTFSSSSYSSS 4529
Score = 111 bits (278), Expect = 7e-24
Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)
Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
E+++ + + + ++LEEEL RL R+A + K + L+ L K +AE A A
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1776
Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
EE R + +KQ L+ G+ +EL E+ RL E+ KR+R+ E+ +Q+
Sbjct: 1777 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1833
Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
+ +++ + K E+E A+KEKE E ERLR L ++E ++R E + A+
Sbjct: 1834 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1893
Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
I+E + Q+ + +S L + K L +D R +R LE
Sbjct: 1894 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1950
Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
EL R +S E R K++ E E + + + + + EE ++K + E++ R++ +
Sbjct: 1951 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2010
Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
E+ERL+A++ E RR E + +E+ QL+ + Q+ + + + ++ +
Sbjct: 2011 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2066
Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
E + T+ + V D LR + A
Sbjct: 2067 QELQQTLQQEQSVLDQLRGEAEA 2089
Score = 99.8 bits (247), Expect = 3e-20
Identities = 62/210 (29%), Positives = 109/210 (51%)
Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
L+ S IA + EK+S+ ++R ++ T LLEAQA +G ++ P ++L++
Sbjct: 2696 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2755
Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
+AV +GV+ ++ +L A++A G++ +++S +A+++ + E G R LE Q
Sbjct: 2756 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2815
Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
TGG++DP R+ + A R+G+ D + L D S K P T ++Y + R
Sbjct: 2816 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2875
Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
+ + TGL LL ++KG Y S A
Sbjct: 2876 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2905
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 964 bits (2491), Expect = 0.0
Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)
Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
+D +R+++TA L+E ++I T + L +G +S+ E A +L G GS+AG
Sbjct: 3640 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3699
Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
++ S+ +A +K L+S E +LLEAQAATG ++DP + E+LTVD A+ + L+ +
Sbjct: 3700 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3759
Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
++ +AE+A+TG+ DP++ +T+S+ +A+KK LI E +RLL+AQ+A+GG+VDP LP
Sbjct: 3760 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3819
Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
+VA RG +++D + L++P + +++VDP T +++SY QL RCR + TG LLL +
Sbjct: 3820 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3878
Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
R ++F+G+R+ +T+ ELV S ++ +T +L G S +EV + ++ FL+G+SCIAG+
Sbjct: 3879 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3938
Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
+ + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+ L+L VEEA + G+VG
Sbjct: 3939 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3998
Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 3999 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4058
Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4059 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4118
Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4119 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4178
Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
EEITI+ SDG + +++DR++G QYDI DAI K L+DR DQYR+G+LS+T+FADM+S
Sbjct: 4179 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4238
Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
G S S G SSS + +S + +S+SD EE+ P+A I
Sbjct: 4239 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4284
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++ + DAV++G++D+
Sbjct: 4285 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4344
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
M R+ AQKAF GFE + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+ G
Sbjct: 4345 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4404
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ +EA+++G +D R AQ+L+D +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4405 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4464
Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
EAA+ S+KG SPY++S SGS +GSR+GSR+GSR+GSRRGSFDATG+ +S +
Sbjct: 4465 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4516
Query: 2265 FSSSS 2269
FSSSS
Sbjct: 4517 FSSSS 4521
Score = 597 bits (1538), Expect = e-170
Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)
Query: 78 CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
C + L +A+ ++Q +++ G R+ E++ +A+ + +L + ++ ++ P
Sbjct: 408 CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 467
Query: 136 DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
+ +R+ +L E++ A L ++ P + A + Q ++ T
Sbjct: 468 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 524
Query: 188 TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
+ L W+ + + +D WGVDL SVE + SHRG+H SI ++R ++++ ++D + S
Sbjct: 525 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 584
Query: 247 --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
+ +L+ +Y LL +S R+ L L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 585 ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 644
Query: 299 SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
SD+NTN+ K+E++S M +LE+KEK++ +L+ D+L+ HPA +E++ LQTQW
Sbjct: 645 SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 704
Query: 359 SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
SW+LQ+ CI+ HLKENAAYFQFF + + E L+ LQ+++R+KY CD++ + L + +
Sbjct: 705 SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 764
Query: 419 KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
++ + E+E++ EYK + L ++K +VQLKPR+P + + L A+CDYKQ + VHK
Sbjct: 765 QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 824
Query: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
GDEC L + S W V G + VPSV ++PPPN A + ++E ++A++ LW+
Sbjct: 825 GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 884
Query: 539 QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
QL+++MKSL++W D++ IR+ ++A +T++ E+ + + LELHYQ F+R+SQ +
Sbjct: 885 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 944
Query: 599 MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
FG +D+ + ++ HYQ L+ L Q ++ CQ
Sbjct: 945 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 984
Query: 659 RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
+ EL+ IR Q+E CE R + LPL D+ + +I E + Q +
Sbjct: 985 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1034
Query: 716 --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
+ +A + + + +LA S L++E+ KLE + ++ YL L T+ +
Sbjct: 1035 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094
Query: 774 LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
++ E++L+ +E +L E + V L ++EA + LKK++ ++ ++ EL+
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154
Query: 834 KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
AQ++ + Q++ D+++ ++ E+V QL +RWQ + Q D R +LE+ +QLR YR+
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1214
Query: 894 NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
+ WL DA+RRQ+ +++M DS V L +++ L EI +K EE Q+ A+
Sbjct: 1215 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1274
Query: 954 CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
N+IKDYELQL +Y + LE + + P K+ +QS S ++QE D+ Y EL T + Y
Sbjct: 1275 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333
Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
+F+SE L+ +E+ + + + + EE RLA + + + + + + Q K QAE
Sbjct: 1334 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1391
Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
+ + EE+ R +A +D + K+++ + Q+++ +E +I + E +R R +E
Sbjct: 1392 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451
Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
+ + + ++ R + E + L + E+E ++ + E ERLR +Q+E RKR
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1511
Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
+ E ELA E+ + + +Q E L ++ + E+ + R ++++ L A+
Sbjct: 1512 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571
Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
+ EAE + K+ EK Q++ L + ++ +EEA R+ + + E +ER + E
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1630
Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
+ER Q + + E + +++ +Q E E+ + + E + R+ Q E
Sbjct: 1631 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690
Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
E ++ + + +G ++ A + +L +T +G++ + + E+ R A +
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1745
Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
+ + + V A+ + L+ + E + LEA+A R
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1797
Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
+L ++A R L + RQ+ A E A
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDA 1824
Score = 528 bits (1359), Expect = e-149
Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)
Query: 997 ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
A + A L+ R D RFL E + ++ + + ++ V +E R E+ +
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
+ L + + K + + Q +L A E L++Q EL + A++ + ++L E+
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2364
Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
+E E++R+ + ++ K ++ +A+ + + E +G + +E A
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424
Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
+EK ++ L + Q+ + R RE EL + ++Q+ K++ Q VQ
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2484
Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
E++SLL + + +EQ+KA+L++L +DE+ +A+ E + R +Q++E E
Sbjct: 2485 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2544
Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
+Q++ + + + + EE +R+ + E ++ E+++ L E +RL+ +++ +EE+
Sbjct: 2545 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
R L S T SQ+ ++ + R G E + E FDGLR
Sbjct: 2605 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2650
Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
+KV+A +L E ++ L +L +G +V+E+A +++ +L+G SIAG + EK
Sbjct: 2651 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2710
Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
S+ A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+ ++ + ++ +A
Sbjct: 2711 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2770
Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S +P DVA
Sbjct: 2771 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2830
Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
RG D ++ R L DP D K F DP T + ++Y+QL ERC +P TGL LL +
Sbjct: 2831 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2890
Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
+K ++S FQG + VT+ E+++S R + + +G
Sbjct: 2891 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2948
Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
+I+ +++ + I ++ G C G +Y + + + +
Sbjct: 2949 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 3008
Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
+ ++ VR A+ LLEAQA TG I+
Sbjct: 3009 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3068
Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG +SLFQA+ K LI +
Sbjct: 3069 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3128
Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
G+RLL+AQ++TGGI+DP +SHR+P+D+A RG +EE S LS P D K + DP+T E
Sbjct: 3129 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3188
Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
TY +L++RC D+ TGL LLPL EK + + E E+ +E
Sbjct: 3189 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3233
Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
++K ++ WE I+ R L+ + + ++ I + +
Sbjct: 3234 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3293
Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
+ R LS + L+ V S + SGV S F + +V +S + SV
Sbjct: 3294 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3347
Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
R L L+ S +A I+ + EK+SI E + RG++ + T LLEAQA TG
Sbjct: 3348 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3397
Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
++ P Q+L + +AV GV+ ++ +L A+KA G+ +S +A+++ +
Sbjct: 3398 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3457
Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
+ G R LE Q TGG++DP R+ + A ++G+ + L D S K P T
Sbjct: 3458 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3517
Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
++Y+ + R + + TGLRLL
Sbjct: 3518 HENLTYRQLLERCVEDPETGLRLL 3541
Score = 419 bits (1078), Expect = e-116
Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)
Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
+Q ++ L Q++T E+ I+ I + E+ E++ + L + +E R
Sbjct: 2936 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2991
Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
RE QL+ ERS R E+D +R+ G++ E +++ L+K +
Sbjct: 2992 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3048
Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
A+ L E Q +D + +V+E V E L A P
Sbjct: 3049 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3108
Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
+ SL +A +K LI E + LL+AQ +TGGI+DP ++ ++ +D A AR +D +
Sbjct: 3109 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3168
Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
+ + A + DP +G+ + E ++ D+ TG+ LL L
Sbjct: 3169 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3212
Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
+ A AR +LY L +K V+ PV K V + E
Sbjct: 3213 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3269
Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
+ +E +L+ V++ +SF G+R PV +EL+ SG+L +
Sbjct: 3270 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3329
Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
+L+ G+ + ++ E ++ LQGS C+AGIY E TK+K+ IYEAM+ GL+R TA LL
Sbjct: 3330 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3389
Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
EAQAATGF+VDPV N RL V EA K G+VG E E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3390 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3449
Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
AM K L+ + HGIRLLEAQIATGGIIDP SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3450 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3509
Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
KGFFDPNT ENLTY QL ERC++D ETGL LLPLK EK + V+T+Q T + R +
Sbjct: 3510 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3569
Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
+ + MS+ E + LI E +L +++ +T R++++
Sbjct: 3570 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3621
Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
I + I+K + R + G S ++ ++D+
Sbjct: 3622 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3652
Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
F ++I ++ + L + S + LE S +A ++ + + +S
Sbjct: 3653 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3705
Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
I + +++G++ + + LLEAQA TG ++ P G++L++ +AV +G++ ++ RL A+
Sbjct: 3706 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3765
Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
+A G+ ++ +S +A+K++ +P E R L+ Q TGG+VDP + + E A +
Sbjct: 3766 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3825
Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
+G+++ +L + S + P T ++SY + R +D TG L L +A ++
Sbjct: 3826 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3884
Query: 2211 SKGLPSPYNM 2220
+GL M
Sbjct: 3885 FRGLRKQITM 3894
Score = 372 bits (956), Expect = e-102
Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)
Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
SF G+R+ V+ L ++GIL + L G + DE+ R ++ +LQG S IAG+ +
Sbjct: 2645 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2704
Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
T +KL +Y A++ L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E
Sbjct: 2705 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2764
Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
KLLSAERAVTGY DP TG ISLFQAM K LI + HGIRLLEAQIATGG+IDP SHR+
Sbjct: 2765 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2824
Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2825 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2884
Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
+K + +V D E ++ ++K + K + WE I
Sbjct: 2885 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2928
Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
R L+ + + ++ I ++ +Q + G L L++
Sbjct: 2929 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 2980
Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
V + + S V D +++ + SV ++ + +VR L ++ IA ++
Sbjct: 2981 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3030
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
E +K+SI +++ ++ S LLEAQA TG II P T +L++ +AV G++ +
Sbjct: 3031 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3090
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
+L A+KA G+ + +S +A+K+ +P E G R L+ Q TGG+VDP
Sbjct: 3091 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3150
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ + A +G +D ++ L + AK + P T +Y + R + +TGL LL
Sbjct: 3151 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3210
Query: 2205 EAASVSSK 2212
+ +++
Sbjct: 3211 PLSEKAAR 3218
Score = 259 bits (663), Expect = 2e-68
Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)
Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
D KL F GLRK++T +L Q++D+ T +L +G S+EEV +Q FL G IAG
Sbjct: 3879 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3938
Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
+ KE+ S+ +A +K +I P + LLEAQAATG +IDP + KLTV+ A+ ++
Sbjct: 3939 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3998
Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
+ + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP S
Sbjct: 3999 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4058
Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
LP +VA RGL D ++ L DP D K F DP T++ ++Y+QL ERC +P TGL L
Sbjct: 4059 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4118
Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
L + ++++ S +R + ++V E G++ T EL + +
Sbjct: 4119 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4178
Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
+E+ D + S I + + ++ I +A+ L+ R GT +
Sbjct: 4179 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4234
Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
+L A GF S+ P+ A R + V G D ET
Sbjct: 4235 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4291
Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
+S+ +AM++ L++ G RLLEAQ TGGIIDP R PV A +G ++ + + ++
Sbjct: 4292 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4351
Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
GF DP T+ ++ Q ++ E G L + Q T
Sbjct: 4352 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4396
Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
+++P+T + + EA ++G +D T ++L + G+ L KT +
Sbjct: 4397 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4443
Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
+DA+D+ +V+ + + T+ +G G+++ +G + SR
Sbjct: 4444 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4503
Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
S S ++T SSS+S +
Sbjct: 4504 GS---FDATGSGFSMTFSSSSYSSS 4525
Score = 111 bits (278), Expect = 7e-24
Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)
Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
E+++ + + + ++LEEEL RL R+A + K + L+ L K +AE A A
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1772
Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
EE R + +KQ L+ G+ +EL E+ RL E+ KR+R+ E+ +Q+
Sbjct: 1773 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1829
Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
+ +++ + K E+E A+KEKE E ERLR L ++E ++R E + A+
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889
Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
I+E + Q+ + +S L + K L +D R +R LE
Sbjct: 1890 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946
Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
EL R +S E R K++ E E + + + + + EE ++K + E++ R++ +
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006
Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
E+ERL+A++ E RR E + +E+ QL+ + Q+ + + + ++ +
Sbjct: 2007 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062
Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
E + T+ + V D LR + A
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEA 2085
Score = 99.8 bits (247), Expect = 3e-20
Identities = 62/210 (29%), Positives = 109/210 (51%)
Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
L+ S IA + EK+S+ ++R ++ T LLEAQA +G ++ P ++L++
Sbjct: 2692 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2751
Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
+AV +GV+ ++ +L A++A G++ +++S +A+++ + E G R LE Q
Sbjct: 2752 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2811
Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
TGG++DP R+ + A R+G+ D + L D S K P T ++Y + R
Sbjct: 2812 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2871
Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
+ + TGL LL ++KG Y S A
Sbjct: 2872 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2901
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 964 bits (2491), Expect = 0.0
Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)
Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
+D +R+++TA L+E ++I T + L +G +S+ E A +L G GS+AG
Sbjct: 3608 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3667
Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
++ S+ +A +K L+S E +LLEAQAATG ++DP + E+LTVD A+ + L+ +
Sbjct: 3668 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3727
Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
++ +AE+A+TG+ DP++ +T+S+ +A+KK LI E +RLL+AQ+A+GG+VDP LP
Sbjct: 3728 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3787
Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
+VA RG +++D + L++P + +++VDP T +++SY QL RCR + TG LLL +
Sbjct: 3788 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3846
Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
R ++F+G+R+ +T+ ELV S ++ +T +L G S +EV + ++ FL+G+SCIAG+
Sbjct: 3847 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3906
Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
+ + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+ L+L VEEA + G+VG
Sbjct: 3907 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3966
Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 3967 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4026
Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4027 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4086
Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4087 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4146
Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
EEITI+ SDG + +++DR++G QYDI DAI K L+DR DQYR+G+LS+T+FADM+S
Sbjct: 4147 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4206
Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
G S S G SSS + +S + +S+SD EE+ P+A I
Sbjct: 4207 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4252
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++ + DAV++G++D+
Sbjct: 4253 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4312
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
M R+ AQKAF GFE + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+ G
Sbjct: 4313 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4372
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ +EA+++G +D R AQ+L+D +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4373 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4432
Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
EAA+ S+KG SPY++S SGS +GSR+GSR+GSR+GSRRGSFDATG+ +S +
Sbjct: 4433 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4484
Query: 2265 FSSSS 2269
FSSSS
Sbjct: 4485 FSSSS 4489
Score = 597 bits (1538), Expect = e-170
Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)
Query: 78 CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
C + L +A+ ++Q +++ G R+ E++ +A+ + +L + ++ ++ P
Sbjct: 376 CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 435
Query: 136 DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
+ +R+ +L E++ A L ++ P + A + Q ++ T
Sbjct: 436 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 492
Query: 188 TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
+ L W+ + + +D WGVDL SVE + SHRG+H SI ++R ++++ ++D + S
Sbjct: 493 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 552
Query: 247 --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
+ +L+ +Y LL +S R+ L L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 553 ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 612
Query: 299 SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
SD+NTN+ K+E++S M +LE+KEK++ +L+ D+L+ HPA +E++ LQTQW
Sbjct: 613 SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 672
Query: 359 SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
SW+LQ+ CI+ HLKENAAYFQFF + + E L+ LQ+++R+KY CD++ + L + +
Sbjct: 673 SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 732
Query: 419 KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
++ + E+E++ EYK + L ++K +VQLKPR+P + + L A+CDYKQ + VHK
Sbjct: 733 QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 792
Query: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
GDEC L + S W V G + VPSV ++PPPN A + ++E ++A++ LW+
Sbjct: 793 GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 852
Query: 539 QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
QL+++MKSL++W D++ IR+ ++A +T++ E+ + + LELHYQ F+R+SQ +
Sbjct: 853 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 912
Query: 599 MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
FG +D+ + ++ HYQ L+ L Q ++ CQ
Sbjct: 913 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 952
Query: 659 RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
+ EL+ IR Q+E CE R + LPL D+ + +I E + Q +
Sbjct: 953 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1002
Query: 716 --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
+ +A + + + +LA S L++E+ KLE + ++ YL L T+ +
Sbjct: 1003 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1062
Query: 774 LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
++ E++L+ +E +L E + V L ++EA + LKK++ ++ ++ EL+
Sbjct: 1063 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1122
Query: 834 KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
AQ++ + Q++ D+++ ++ E+V QL +RWQ + Q D R +LE+ +QLR YR+
Sbjct: 1123 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1182
Query: 894 NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
+ WL DA+RRQ+ +++M DS V L +++ L EI +K EE Q+ A+
Sbjct: 1183 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1242
Query: 954 CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
N+IKDYELQL +Y + LE + + P K+ +QS S ++QE D+ Y EL T + Y
Sbjct: 1243 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1301
Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
+F+SE L+ +E+ + + + + EE RLA + + + + + + Q K QAE
Sbjct: 1302 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1359
Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
+ + EE+ R +A +D + K+++ + Q+++ +E +I + E +R R +E
Sbjct: 1360 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1419
Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
+ + + ++ R + E + L + E+E ++ + E ERLR +Q+E RKR
Sbjct: 1420 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1479
Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
+ E ELA E+ + + +Q E L ++ + E+ + R ++++ L A+
Sbjct: 1480 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1539
Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
+ EAE + K+ EK Q++ L + ++ +EEA R+ + + E +ER + E
Sbjct: 1540 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1598
Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
+ER Q + + E + +++ +Q E E+ + + E + R+ Q E
Sbjct: 1599 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1658
Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
E ++ + + +G ++ A + +L +T +G++ + + E+ R A +
Sbjct: 1659 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1713
Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
+ + + V A+ + L+ + E + LEA+A R
Sbjct: 1714 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1765
Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
+L ++A R L + RQ+ A E A
Sbjct: 1766 ELAEEAARLRALAEEAKRQRQLAEEDA 1792
Score = 528 bits (1359), Expect = e-149
Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)
Query: 997 ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
A + A L+ R D RFL E + ++ + + ++ V +E R E+ +
Sbjct: 2213 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2272
Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
+ L + + K + + Q +L A E L++Q EL + A++ + ++L E+
Sbjct: 2273 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2332
Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
+E E++R+ + ++ K ++ +A+ + + E +G + +E A
Sbjct: 2333 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2392
Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
+EK ++ L + Q+ + R RE EL + ++Q+ K++ Q VQ
Sbjct: 2393 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2452
Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
E++SLL + + +EQ+KA+L++L +DE+ +A+ E + R +Q++E E
Sbjct: 2453 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2512
Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
+Q++ + + + + EE +R+ + E ++ E+++ L E +RL+ +++ +EE+
Sbjct: 2513 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
R L S T SQ+ ++ + R G E + E FDGLR
Sbjct: 2573 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2618
Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
+KV+A +L E ++ L +L +G +V+E+A +++ +L+G SIAG + EK
Sbjct: 2619 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2678
Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
S+ A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+ ++ + ++ +A
Sbjct: 2679 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2738
Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S +P DVA
Sbjct: 2739 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2798
Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
RG D ++ R L DP D K F DP T + ++Y+QL ERC +P TGL LL +
Sbjct: 2799 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2858
Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
+K ++S FQG + VT+ E+++S R + + +G
Sbjct: 2859 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2916
Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
+I+ +++ + I ++ G C G +Y + + + +
Sbjct: 2917 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 2976
Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
+ ++ VR A+ LLEAQA TG I+
Sbjct: 2977 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3036
Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG +SLFQA+ K LI +
Sbjct: 3037 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3096
Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
G+RLL+AQ++TGGI+DP +SHR+P+D+A RG +EE S LS P D K + DP+T E
Sbjct: 3097 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3156
Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
TY +L++RC D+ TGL LLPL EK + + E E+ +E
Sbjct: 3157 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3201
Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
++K ++ WE I+ R L+ + + ++ I + +
Sbjct: 3202 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3261
Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
+ R LS + L+ V S + SGV S F + +V +S + SV
Sbjct: 3262 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3315
Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
R L L+ S +A I+ + EK+SI E + RG++ + T LLEAQA TG
Sbjct: 3316 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3365
Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
++ P Q+L + +AV GV+ ++ +L A+KA G+ +S +A+++ +
Sbjct: 3366 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3425
Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
+ G R LE Q TGG++DP R+ + A ++G+ + L D S K P T
Sbjct: 3426 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3485
Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
++Y+ + R + + TGLRLL
Sbjct: 3486 HENLTYRQLLERCVEDPETGLRLL 3509
Score = 419 bits (1078), Expect = e-116
Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)
Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
+Q ++ L Q++T E+ I+ I + E+ E++ + L + +E R
Sbjct: 2904 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2959
Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
RE QL+ ERS R E+D +R+ G++ E +++ L+K +
Sbjct: 2960 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3016
Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
A+ L E Q +D + +V+E V E L A P
Sbjct: 3017 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3076
Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
+ SL +A +K LI E + LL+AQ +TGGI+DP ++ ++ +D A AR +D +
Sbjct: 3077 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3136
Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
+ + A + DP +G+ + E ++ D+ TG+ LL L
Sbjct: 3137 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3180
Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
+ A AR +LY L +K V+ PV K V + E
Sbjct: 3181 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3237
Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
+ +E +L+ V++ +SF G+R PV +EL+ SG+L +
Sbjct: 3238 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3297
Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
+L+ G+ + ++ E ++ LQGS C+AGIY E TK+K+ IYEAM+ GL+R TA LL
Sbjct: 3298 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3357
Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
EAQAATGF+VDPV N RL V EA K G+VG E E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3358 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3417
Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
AM K L+ + HGIRLLEAQIATGGIIDP SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3418 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3477
Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
KGFFDPNT ENLTY QL ERC++D ETGL LLPLK EK + V+T+Q T + R +
Sbjct: 3478 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3537
Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
+ + MS+ E + LI E +L +++ +T R++++
Sbjct: 3538 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3589
Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
I + I+K + R + G S ++ ++D+
Sbjct: 3590 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3620
Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
F ++I ++ + L + S + LE S +A ++ + + +S
Sbjct: 3621 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3673
Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
I + +++G++ + + LLEAQA TG ++ P G++L++ +AV +G++ ++ RL A+
Sbjct: 3674 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3733
Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
+A G+ ++ +S +A+K++ +P E R L+ Q TGG+VDP + + E A +
Sbjct: 3734 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3793
Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
+G+++ +L + S + P T ++SY + R +D TG L L +A ++
Sbjct: 3794 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3852
Query: 2211 SKGLPSPYNM 2220
+GL M
Sbjct: 3853 FRGLRKQITM 3862
Score = 372 bits (956), Expect = e-102
Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)
Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
SF G+R+ V+ L ++GIL + L G + DE+ R ++ +LQG S IAG+ +
Sbjct: 2613 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2672
Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
T +KL +Y A++ L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E
Sbjct: 2673 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2732
Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
KLLSAERAVTGY DP TG ISLFQAM K LI + HGIRLLEAQIATGG+IDP SHR+
Sbjct: 2733 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2792
Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2793 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2852
Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
+K + +V D E ++ ++K + K + WE I
Sbjct: 2853 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2896
Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
R L+ + + ++ I ++ +Q + G L L++
Sbjct: 2897 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 2948
Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
V + + S V D +++ + SV ++ + +VR L ++ IA ++
Sbjct: 2949 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 2998
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
E +K+SI +++ ++ S LLEAQA TG II P T +L++ +AV G++ +
Sbjct: 2999 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3058
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
+L A+KA G+ + +S +A+K+ +P E G R L+ Q TGG+VDP
Sbjct: 3059 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3118
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ + A +G +D ++ L + AK + P T +Y + R + +TGL LL
Sbjct: 3119 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3178
Query: 2205 EAASVSSK 2212
+ +++
Sbjct: 3179 PLSEKAAR 3186
Score = 259 bits (663), Expect = 2e-68
Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)
Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
D KL F GLRK++T +L Q++D+ T +L +G S+EEV +Q FL G IAG
Sbjct: 3847 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3906
Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
+ KE+ S+ +A +K +I P + LLEAQAATG +IDP + KLTV+ A+ ++
Sbjct: 3907 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3966
Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
+ + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP S
Sbjct: 3967 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4026
Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
LP +VA RGL D ++ L DP D K F DP T++ ++Y+QL ERC +P TGL L
Sbjct: 4027 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4086
Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
L + ++++ S +R + ++V E G++ T EL + +
Sbjct: 4087 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4146
Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
+E+ D + S I + + ++ I +A+ L+ R GT +
Sbjct: 4147 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4202
Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
+L A GF S+ P+ A R + V G D ET
Sbjct: 4203 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4259
Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
+S+ +AM++ L++ G RLLEAQ TGGIIDP R PV A +G ++ + + ++
Sbjct: 4260 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4319
Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
GF DP T+ ++ Q ++ E G L + Q T
Sbjct: 4320 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4364
Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
+++P+T + + EA ++G +D T ++L + G+ L KT +
Sbjct: 4365 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4411
Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
+DA+D+ +V+ + + T+ +G G+++ +G + SR
Sbjct: 4412 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4471
Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
S S ++T SSS+S +
Sbjct: 4472 GS---FDATGSGFSMTFSSSSYSSS 4493
Score = 111 bits (278), Expect = 7e-24
Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)
Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
E+++ + + + ++LEEEL RL R+A + K + L+ L K +AE A A
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1740
Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
EE R + +KQ L+ G+ +EL E+ RL E+ KR+R+ E+ +Q+
Sbjct: 1741 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1797
Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
+ +++ + K E+E A+KEKE E ERLR L ++E ++R E + A+
Sbjct: 1798 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1857
Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
I+E + Q+ + +S L + K L +D R +R LE
Sbjct: 1858 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1914
Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
EL R +S E R K++ E E + + + + + EE ++K + E++ R++ +
Sbjct: 1915 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1974
Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
E+ERL+A++ E RR E + +E+ QL+ + Q+ + + + ++ +
Sbjct: 1975 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2030
Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
E + T+ + V D LR + A
Sbjct: 2031 QELQQTLQQEQSVLDQLRGEAEA 2053
Score = 99.8 bits (247), Expect = 3e-20
Identities = 62/210 (29%), Positives = 109/210 (51%)
Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
L+ S IA + EK+S+ ++R ++ T LLEAQA +G ++ P ++L++
Sbjct: 2660 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2719
Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
+AV +GV+ ++ +L A++A G++ +++S +A+++ + E G R LE Q
Sbjct: 2720 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2779
Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
TGG++DP R+ + A R+G+ D + L D S K P T ++Y + R
Sbjct: 2780 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2839
Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
+ + TGL LL ++KG Y S A
Sbjct: 2840 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2869
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 964 bits (2491), Expect = 0.0
Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)
Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
+D +R+++TA L+E ++I T + L +G +S+ E A +L G GS+AG
Sbjct: 3777 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3836
Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
++ S+ +A +K L+S E +LLEAQAATG ++DP + E+LTVD A+ + L+ +
Sbjct: 3837 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3896
Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
++ +AE+A+TG+ DP++ +T+S+ +A+KK LI E +RLL+AQ+A+GG+VDP LP
Sbjct: 3897 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3956
Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
+VA RG +++D + L++P + +++VDP T +++SY QL RCR + TG LLL +
Sbjct: 3957 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 4015
Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
R ++F+G+R+ +T+ ELV S ++ +T +L G S +EV + ++ FL+G+SCIAG+
Sbjct: 4016 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 4075
Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
+ + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+ L+L VEEA + G+VG
Sbjct: 4076 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4135
Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 4136 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4195
Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4196 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4255
Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4256 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4315
Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
EEITI+ SDG + +++DR++G QYDI DAI K L+DR DQYR+G+LS+T+FADM+S
Sbjct: 4316 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4375
Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
G S S G SSS + +S + +S+SD EE+ P+A I
Sbjct: 4376 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4421
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++ + DAV++G++D+
Sbjct: 4422 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4481
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
M R+ AQKAF GFE + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+ G
Sbjct: 4482 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4541
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ +EA+++G +D R AQ+L+D +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4542 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4601
Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
EAA+ S+KG SPY++S SGS +GSR+GSR+GSR+GSRRGSFDATG+ +S +
Sbjct: 4602 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4653
Query: 2265 FSSSS 2269
FSSSS
Sbjct: 4654 FSSSS 4658
Score = 597 bits (1538), Expect = e-170
Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)
Query: 78 CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
C + L +A+ ++Q +++ G R+ E++ +A+ + +L + ++ ++ P
Sbjct: 545 CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 604
Query: 136 DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
+ +R+ +L E++ A L ++ P + A + Q ++ T
Sbjct: 605 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 661
Query: 188 TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
+ L W+ + + +D WGVDL SVE + SHRG+H SI ++R ++++ ++D + S
Sbjct: 662 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 721
Query: 247 --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
+ +L+ +Y LL +S R+ L L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 722 ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 781
Query: 299 SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
SD+NTN+ K+E++S M +LE+KEK++ +L+ D+L+ HPA +E++ LQTQW
Sbjct: 782 SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 841
Query: 359 SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
SW+LQ+ CI+ HLKENAAYFQFF + + E L+ LQ+++R+KY CD++ + L + +
Sbjct: 842 SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 901
Query: 419 KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
++ + E+E++ EYK + L ++K +VQLKPR+P + + L A+CDYKQ + VHK
Sbjct: 902 QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 961
Query: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
GDEC L + S W V G + VPSV ++PPPN A + ++E ++A++ LW+
Sbjct: 962 GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 1021
Query: 539 QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
QL+++MKSL++W D++ IR+ ++A +T++ E+ + + LELHYQ F+R+SQ +
Sbjct: 1022 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 1081
Query: 599 MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
FG +D+ + ++ HYQ L+ L Q ++ CQ
Sbjct: 1082 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 1121
Query: 659 RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
+ EL+ IR Q+E CE R + LPL D+ + +I E + Q +
Sbjct: 1122 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1171
Query: 716 --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
+ +A + + + +LA S L++E+ KLE + ++ YL L T+ +
Sbjct: 1172 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1231
Query: 774 LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
++ E++L+ +E +L E + V L ++EA + LKK++ ++ ++ EL+
Sbjct: 1232 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1291
Query: 834 KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
AQ++ + Q++ D+++ ++ E+V QL +RWQ + Q D R +LE+ +QLR YR+
Sbjct: 1292 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1351
Query: 894 NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
+ WL DA+RRQ+ +++M DS V L +++ L EI +K EE Q+ A+
Sbjct: 1352 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1411
Query: 954 CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
N+IKDYELQL +Y + LE + + P K+ +QS S ++QE D+ Y EL T + Y
Sbjct: 1412 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1470
Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
+F+SE L+ +E+ + + + + EE RLA + + + + + + Q K QAE
Sbjct: 1471 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1528
Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
+ + EE+ R +A +D + K+++ + Q+++ +E +I + E +R R +E
Sbjct: 1529 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1588
Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
+ + + ++ R + E + L + E+E ++ + E ERLR +Q+E RKR
Sbjct: 1589 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1648
Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
+ E ELA E+ + + +Q E L ++ + E+ + R ++++ L A+
Sbjct: 1649 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1708
Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
+ EAE + K+ EK Q++ L + ++ +EEA R+ + + E +ER + E
Sbjct: 1709 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1767
Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
+ER Q + + E + +++ +Q E E+ + + E + R+ Q E
Sbjct: 1768 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1827
Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
E ++ + + +G ++ A + +L +T +G++ + + E+ R A +
Sbjct: 1828 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1882
Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
+ + + V A+ + L+ + E + LEA+A R
Sbjct: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1934
Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
+L ++A R L + RQ+ A E A
Sbjct: 1935 ELAEEAARLRALAEEAKRQRQLAEEDA 1961
Score = 528 bits (1359), Expect = e-149
Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)
Query: 997 ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
A + A L+ R D RFL E + ++ + + ++ V +E R E+ +
Sbjct: 2382 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2441
Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
+ L + + K + + Q +L A E L++Q EL + A++ + ++L E+
Sbjct: 2442 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2501
Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
+E E++R+ + ++ K ++ +A+ + + E +G + +E A
Sbjct: 2502 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2561
Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
+EK ++ L + Q+ + R RE EL + ++Q+ K++ Q VQ
Sbjct: 2562 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2621
Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
E++SLL + + +EQ+KA+L++L +DE+ +A+ E + R +Q++E E
Sbjct: 2622 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2681
Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
+Q++ + + + + EE +R+ + E ++ E+++ L E +RL+ +++ +EE+
Sbjct: 2682 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
R L S T SQ+ ++ + R G E + E FDGLR
Sbjct: 2742 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2787
Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
+KV+A +L E ++ L +L +G +V+E+A +++ +L+G SIAG + EK
Sbjct: 2788 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2847
Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
S+ A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+ ++ + ++ +A
Sbjct: 2848 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2907
Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S +P DVA
Sbjct: 2908 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2967
Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
RG D ++ R L DP D K F DP T + ++Y+QL ERC +P TGL LL +
Sbjct: 2968 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 3027
Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
+K ++S FQG + VT+ E+++S R + + +G
Sbjct: 3028 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 3085
Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
+I+ +++ + I ++ G C G +Y + + + +
Sbjct: 3086 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 3145
Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
+ ++ VR A+ LLEAQA TG I+
Sbjct: 3146 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3205
Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG +SLFQA+ K LI +
Sbjct: 3206 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3265
Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
G+RLL+AQ++TGGI+DP +SHR+P+D+A RG +EE S LS P D K + DP+T E
Sbjct: 3266 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3325
Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
TY +L++RC D+ TGL LLPL EK + + E E+ +E
Sbjct: 3326 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3370
Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
++K ++ WE I+ R L+ + + ++ I + +
Sbjct: 3371 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3430
Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
+ R LS + L+ V S + SGV S F + +V +S + SV
Sbjct: 3431 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3484
Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
R L L+ S +A I+ + EK+SI E + RG++ + T LLEAQA TG
Sbjct: 3485 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3534
Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
++ P Q+L + +AV GV+ ++ +L A+KA G+ +S +A+++ +
Sbjct: 3535 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3594
Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
+ G R LE Q TGG++DP R+ + A ++G+ + L D S K P T
Sbjct: 3595 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3654
Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
++Y+ + R + + TGLRLL
Sbjct: 3655 HENLTYRQLLERCVEDPETGLRLL 3678
Score = 419 bits (1078), Expect = e-116
Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)
Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
+Q ++ L Q++T E+ I+ I + E+ E++ + L + +E R
Sbjct: 3073 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 3128
Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
RE QL+ ERS R E+D +R+ G++ E +++ L+K +
Sbjct: 3129 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3185
Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
A+ L E Q +D + +V+E V E L A P
Sbjct: 3186 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3245
Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
+ SL +A +K LI E + LL+AQ +TGGI+DP ++ ++ +D A AR +D +
Sbjct: 3246 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3305
Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
+ + A + DP +G+ + E ++ D+ TG+ LL L
Sbjct: 3306 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3349
Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
+ A AR +LY L +K V+ PV K V + E
Sbjct: 3350 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3406
Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
+ +E +L+ V++ +SF G+R PV +EL+ SG+L +
Sbjct: 3407 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3466
Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
+L+ G+ + ++ E ++ LQGS C+AGIY E TK+K+ IYEAM+ GL+R TA LL
Sbjct: 3467 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3526
Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
EAQAATGF+VDPV N RL V EA K G+VG E E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3527 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3586
Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
AM K L+ + HGIRLLEAQIATGGIIDP SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3587 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3646
Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
KGFFDPNT ENLTY QL ERC++D ETGL LLPLK EK + V+T+Q T + R +
Sbjct: 3647 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3706
Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
+ + MS+ E + LI E +L +++ +T R++++
Sbjct: 3707 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3758
Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
I + I+K + R + G S ++ ++D+
Sbjct: 3759 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3789
Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
F ++I ++ + L + S + LE S +A ++ + + +S
Sbjct: 3790 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3842
Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
I + +++G++ + + LLEAQA TG ++ P G++L++ +AV +G++ ++ RL A+
Sbjct: 3843 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3902
Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
+A G+ ++ +S +A+K++ +P E R L+ Q TGG+VDP + + E A +
Sbjct: 3903 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3962
Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
+G+++ +L + S + P T ++SY + R +D TG L L +A ++
Sbjct: 3963 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 4021
Query: 2211 SKGLPSPYNM 2220
+GL M
Sbjct: 4022 FRGLRKQITM 4031
Score = 372 bits (956), Expect = e-102
Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)
Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
SF G+R+ V+ L ++GIL + L G + DE+ R ++ +LQG S IAG+ +
Sbjct: 2782 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2841
Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
T +KL +Y A++ L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E
Sbjct: 2842 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2901
Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
KLLSAERAVTGY DP TG ISLFQAM K LI + HGIRLLEAQIATGG+IDP SHR+
Sbjct: 2902 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2961
Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2962 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 3021
Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
+K + +V D E ++ ++K + K + WE I
Sbjct: 3022 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 3065
Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
R L+ + + ++ I ++ +Q + G L L++
Sbjct: 3066 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 3117
Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
V + + S V D +++ + SV ++ + +VR L ++ IA ++
Sbjct: 3118 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3167
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
E +K+SI +++ ++ S LLEAQA TG II P T +L++ +AV G++ +
Sbjct: 3168 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3227
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
+L A+KA G+ + +S +A+K+ +P E G R L+ Q TGG+VDP
Sbjct: 3228 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3287
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ + A +G +D ++ L + AK + P T +Y + R + +TGL LL
Sbjct: 3288 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3347
Query: 2205 EAASVSSK 2212
+ +++
Sbjct: 3348 PLSEKAAR 3355
Score = 259 bits (663), Expect = 2e-68
Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)
Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
D KL F GLRK++T +L Q++D+ T +L +G S+EEV +Q FL G IAG
Sbjct: 4016 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 4075
Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
+ KE+ S+ +A +K +I P + LLEAQAATG +IDP + KLTV+ A+ ++
Sbjct: 4076 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4135
Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
+ + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP S
Sbjct: 4136 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4195
Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
LP +VA RGL D ++ L DP D K F DP T++ ++Y+QL ERC +P TGL L
Sbjct: 4196 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4255
Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
L + ++++ S +R + ++V E G++ T EL + +
Sbjct: 4256 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4315
Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
+E+ D + S I + + ++ I +A+ L+ R GT +
Sbjct: 4316 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4371
Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
+L A GF S+ P+ A R + V G D ET
Sbjct: 4372 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4428
Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
+S+ +AM++ L++ G RLLEAQ TGGIIDP R PV A +G ++ + + ++
Sbjct: 4429 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4488
Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
GF DP T+ ++ Q ++ E G L + Q T
Sbjct: 4489 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4533
Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
+++P+T + + EA ++G +D T ++L + G+ L KT +
Sbjct: 4534 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4580
Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
+DA+D+ +V+ + + T+ +G G+++ +G + SR
Sbjct: 4581 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4640
Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
S S ++T SSS+S +
Sbjct: 4641 GS---FDATGSGFSMTFSSSSYSSS 4662
Score = 111 bits (278), Expect = 7e-24
Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)
Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
E+++ + + + ++LEEEL RL R+A + K + L+ L K +AE A A
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1909
Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
EE R + +KQ L+ G+ +EL E+ RL E+ KR+R+ E+ +Q+
Sbjct: 1910 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1966
Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
+ +++ + K E+E A+KEKE E ERLR L ++E ++R E + A+
Sbjct: 1967 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 2026
Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
I+E + Q+ + +S L + K L +D R +R LE
Sbjct: 2027 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 2083
Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
EL R +S E R K++ E E + + + + + EE ++K + E++ R++ +
Sbjct: 2084 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2143
Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
E+ERL+A++ E RR E + +E+ QL+ + Q+ + + + ++ +
Sbjct: 2144 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2199
Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
E + T+ + V D LR + A
Sbjct: 2200 QELQQTLQQEQSVLDQLRGEAEA 2222
Score = 99.8 bits (247), Expect = 3e-20
Identities = 62/210 (29%), Positives = 109/210 (51%)
Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
L+ S IA + EK+S+ ++R ++ T LLEAQA +G ++ P ++L++
Sbjct: 2829 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2888
Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
+AV +GV+ ++ +L A++A G++ +++S +A+++ + E G R LE Q
Sbjct: 2889 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2948
Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
TGG++DP R+ + A R+G+ D + L D S K P T ++Y + R
Sbjct: 2949 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 3008
Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
+ + TGL LL ++KG Y S A
Sbjct: 3009 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 3038
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 964 bits (2491), Expect = 0.0
Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)
Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
+D +R+++TA L+E ++I T + L +G +S+ E A +L G GS+AG
Sbjct: 3618 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3677
Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
++ S+ +A +K L+S E +LLEAQAATG ++DP + E+LTVD A+ + L+ +
Sbjct: 3678 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3737
Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
++ +AE+A+TG+ DP++ +T+S+ +A+KK LI E +RLL+AQ+A+GG+VDP LP
Sbjct: 3738 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3797
Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
+VA RG +++D + L++P + +++VDP T +++SY QL RCR + TG LLL +
Sbjct: 3798 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3856
Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
R ++F+G+R+ +T+ ELV S ++ +T +L G S +EV + ++ FL+G+SCIAG+
Sbjct: 3857 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3916
Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
+ + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+ L+L VEEA + G+VG
Sbjct: 3917 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3976
Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 3977 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4036
Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4037 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4096
Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4097 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4156
Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
EEITI+ SDG + +++DR++G QYDI DAI K L+DR DQYR+G+LS+T+FADM+S
Sbjct: 4157 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4216
Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
G S S G SSS + +S + +S+SD EE+ P+A I
Sbjct: 4217 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4262
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++ + DAV++G++D+
Sbjct: 4263 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4322
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
M R+ AQKAF GFE + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+ G
Sbjct: 4323 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4382
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ +EA+++G +D R AQ+L+D +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4383 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4442
Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
EAA+ S+KG SPY++S SGS +GSR+GSR+GSR+GSRRGSFDATG+ +S +
Sbjct: 4443 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4494
Query: 2265 FSSSS 2269
FSSSS
Sbjct: 4495 FSSSS 4499
Score = 597 bits (1538), Expect = e-170
Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)
Query: 78 CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
C + L +A+ ++Q +++ G R+ E++ +A+ + +L + ++ ++ P
Sbjct: 386 CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 445
Query: 136 DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
+ +R+ +L E++ A L ++ P + A + Q ++ T
Sbjct: 446 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 502
Query: 188 TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
+ L W+ + + +D WGVDL SVE + SHRG+H SI ++R ++++ ++D + S
Sbjct: 503 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 562
Query: 247 --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
+ +L+ +Y LL +S R+ L L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 563 ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 622
Query: 299 SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
SD+NTN+ K+E++S M +LE+KEK++ +L+ D+L+ HPA +E++ LQTQW
Sbjct: 623 SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 682
Query: 359 SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
SW+LQ+ CI+ HLKENAAYFQFF + + E L+ LQ+++R+KY CD++ + L + +
Sbjct: 683 SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 742
Query: 419 KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
++ + E+E++ EYK + L ++K +VQLKPR+P + + L A+CDYKQ + VHK
Sbjct: 743 QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 802
Query: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
GDEC L + S W V G + VPSV ++PPPN A + ++E ++A++ LW+
Sbjct: 803 GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 862
Query: 539 QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
QL+++MKSL++W D++ IR+ ++A +T++ E+ + + LELHYQ F+R+SQ +
Sbjct: 863 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 922
Query: 599 MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
FG +D+ + ++ HYQ L+ L Q ++ CQ
Sbjct: 923 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 962
Query: 659 RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
+ EL+ IR Q+E CE R + LPL D+ + +I E + Q +
Sbjct: 963 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1012
Query: 716 --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
+ +A + + + +LA S L++E+ KLE + ++ YL L T+ +
Sbjct: 1013 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1072
Query: 774 LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
++ E++L+ +E +L E + V L ++EA + LKK++ ++ ++ EL+
Sbjct: 1073 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1132
Query: 834 KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
AQ++ + Q++ D+++ ++ E+V QL +RWQ + Q D R +LE+ +QLR YR+
Sbjct: 1133 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1192
Query: 894 NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
+ WL DA+RRQ+ +++M DS V L +++ L EI +K EE Q+ A+
Sbjct: 1193 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1252
Query: 954 CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
N+IKDYELQL +Y + LE + + P K+ +QS S ++QE D+ Y EL T + Y
Sbjct: 1253 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1311
Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
+F+SE L+ +E+ + + + + EE RLA + + + + + + Q K QAE
Sbjct: 1312 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1369
Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
+ + EE+ R +A +D + K+++ + Q+++ +E +I + E +R R +E
Sbjct: 1370 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1429
Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
+ + + ++ R + E + L + E+E ++ + E ERLR +Q+E RKR
Sbjct: 1430 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1489
Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
+ E ELA E+ + + +Q E L ++ + E+ + R ++++ L A+
Sbjct: 1490 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1549
Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
+ EAE + K+ EK Q++ L + ++ +EEA R+ + + E +ER + E
Sbjct: 1550 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1608
Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
+ER Q + + E + +++ +Q E E+ + + E + R+ Q E
Sbjct: 1609 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1668
Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
E ++ + + +G ++ A + +L +T +G++ + + E+ R A +
Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1723
Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
+ + + V A+ + L+ + E + LEA+A R
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1775
Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
+L ++A R L + RQ+ A E A
Sbjct: 1776 ELAEEAARLRALAEEAKRQRQLAEEDA 1802
Score = 528 bits (1359), Expect = e-149
Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)
Query: 997 ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
A + A L+ R D RFL E + ++ + + ++ V +E R E+ +
Sbjct: 2223 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2282
Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
+ L + + K + + Q +L A E L++Q EL + A++ + ++L E+
Sbjct: 2283 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2342
Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
+E E++R+ + ++ K ++ +A+ + + E +G + +E A
Sbjct: 2343 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2402
Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
+EK ++ L + Q+ + R RE EL + ++Q+ K++ Q VQ
Sbjct: 2403 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2462
Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
E++SLL + + +EQ+KA+L++L +DE+ +A+ E + R +Q++E E
Sbjct: 2463 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2522
Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
+Q++ + + + + EE +R+ + E ++ E+++ L E +RL+ +++ +EE+
Sbjct: 2523 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
R L S T SQ+ ++ + R G E + E FDGLR
Sbjct: 2583 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2628
Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
+KV+A +L E ++ L +L +G +V+E+A +++ +L+G SIAG + EK
Sbjct: 2629 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2688
Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
S+ A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+ ++ + ++ +A
Sbjct: 2689 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2748
Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S +P DVA
Sbjct: 2749 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2808
Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
RG D ++ R L DP D K F DP T + ++Y+QL ERC +P TGL LL +
Sbjct: 2809 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2868
Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
+K ++S FQG + VT+ E+++S R + + +G
Sbjct: 2869 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2926
Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
+I+ +++ + I ++ G C G +Y + + + +
Sbjct: 2927 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 2986
Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
+ ++ VR A+ LLEAQA TG I+
Sbjct: 2987 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3046
Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG +SLFQA+ K LI +
Sbjct: 3047 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3106
Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
G+RLL+AQ++TGGI+DP +SHR+P+D+A RG +EE S LS P D K + DP+T E
Sbjct: 3107 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3166
Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
TY +L++RC D+ TGL LLPL EK + + E E+ +E
Sbjct: 3167 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3211
Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
++K ++ WE I+ R L+ + + ++ I + +
Sbjct: 3212 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3271
Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
+ R LS + L+ V S + SGV S F + +V +S + SV
Sbjct: 3272 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3325
Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
R L L+ S +A I+ + EK+SI E + RG++ + T LLEAQA TG
Sbjct: 3326 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3375
Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
++ P Q+L + +AV GV+ ++ +L A+KA G+ +S +A+++ +
Sbjct: 3376 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3435
Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
+ G R LE Q TGG++DP R+ + A ++G+ + L D S K P T
Sbjct: 3436 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3495
Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
++Y+ + R + + TGLRLL
Sbjct: 3496 HENLTYRQLLERCVEDPETGLRLL 3519
Score = 419 bits (1078), Expect = e-116
Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)
Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
+Q ++ L Q++T E+ I+ I + E+ E++ + L + +E R
Sbjct: 2914 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2969
Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
RE QL+ ERS R E+D +R+ G++ E +++ L+K +
Sbjct: 2970 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3026
Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
A+ L E Q +D + +V+E V E L A P
Sbjct: 3027 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3086
Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
+ SL +A +K LI E + LL+AQ +TGGI+DP ++ ++ +D A AR +D +
Sbjct: 3087 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3146
Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
+ + A + DP +G+ + E ++ D+ TG+ LL L
Sbjct: 3147 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3190
Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
+ A AR +LY L +K V+ PV K V + E
Sbjct: 3191 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3247
Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
+ +E +L+ V++ +SF G+R PV +EL+ SG+L +
Sbjct: 3248 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3307
Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
+L+ G+ + ++ E ++ LQGS C+AGIY E TK+K+ IYEAM+ GL+R TA LL
Sbjct: 3308 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3367
Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
EAQAATGF+VDPV N RL V EA K G+VG E E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3368 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3427
Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
AM K L+ + HGIRLLEAQIATGGIIDP SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3428 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3487
Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
KGFFDPNT ENLTY QL ERC++D ETGL LLPLK EK + V+T+Q T + R +
Sbjct: 3488 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3547
Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
+ + MS+ E + LI E +L +++ +T R++++
Sbjct: 3548 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3599
Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
I + I+K + R + G S ++ ++D+
Sbjct: 3600 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3630
Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
F ++I ++ + L + S + LE S +A ++ + + +S
Sbjct: 3631 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3683
Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
I + +++G++ + + LLEAQA TG ++ P G++L++ +AV +G++ ++ RL A+
Sbjct: 3684 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3743
Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
+A G+ ++ +S +A+K++ +P E R L+ Q TGG+VDP + + E A +
Sbjct: 3744 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3803
Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
+G+++ +L + S + P T ++SY + R +D TG L L +A ++
Sbjct: 3804 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3862
Query: 2211 SKGLPSPYNM 2220
+GL M
Sbjct: 3863 FRGLRKQITM 3872
Score = 372 bits (956), Expect = e-102
Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)
Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
SF G+R+ V+ L ++GIL + L G + DE+ R ++ +LQG S IAG+ +
Sbjct: 2623 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2682
Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
T +KL +Y A++ L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E
Sbjct: 2683 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2742
Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
KLLSAERAVTGY DP TG ISLFQAM K LI + HGIRLLEAQIATGG+IDP SHR+
Sbjct: 2743 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2802
Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2803 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2862
Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
+K + +V D E ++ ++K + K + WE I
Sbjct: 2863 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2906
Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
R L+ + + ++ I ++ +Q + G L L++
Sbjct: 2907 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 2958
Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
V + + S V D +++ + SV ++ + +VR L ++ IA ++
Sbjct: 2959 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3008
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
E +K+SI +++ ++ S LLEAQA TG II P T +L++ +AV G++ +
Sbjct: 3009 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3068
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
+L A+KA G+ + +S +A+K+ +P E G R L+ Q TGG+VDP
Sbjct: 3069 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3128
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ + A +G +D ++ L + AK + P T +Y + R + +TGL LL
Sbjct: 3129 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3188
Query: 2205 EAASVSSK 2212
+ +++
Sbjct: 3189 PLSEKAAR 3196
Score = 259 bits (663), Expect = 2e-68
Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)
Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
D KL F GLRK++T +L Q++D+ T +L +G S+EEV +Q FL G IAG
Sbjct: 3857 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3916
Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
+ KE+ S+ +A +K +I P + LLEAQAATG +IDP + KLTV+ A+ ++
Sbjct: 3917 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3976
Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
+ + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP S
Sbjct: 3977 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4036
Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
LP +VA RGL D ++ L DP D K F DP T++ ++Y+QL ERC +P TGL L
Sbjct: 4037 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4096
Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
L + ++++ S +R + ++V E G++ T EL + +
Sbjct: 4097 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4156
Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
+E+ D + S I + + ++ I +A+ L+ R GT +
Sbjct: 4157 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4212
Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
+L A GF S+ P+ A R + V G D ET
Sbjct: 4213 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4269
Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
+S+ +AM++ L++ G RLLEAQ TGGIIDP R PV A +G ++ + + ++
Sbjct: 4270 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4329
Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
GF DP T+ ++ Q ++ E G L + Q T
Sbjct: 4330 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4374
Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
+++P+T + + EA ++G +D T ++L + G+ L KT +
Sbjct: 4375 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4421
Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
+DA+D+ +V+ + + T+ +G G+++ +G + SR
Sbjct: 4422 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4481
Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
S S ++T SSS+S +
Sbjct: 4482 GS---FDATGSGFSMTFSSSSYSSS 4503
Score = 111 bits (278), Expect = 7e-24
Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)
Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
E+++ + + + ++LEEEL RL R+A + K + L+ L K +AE A A
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1750
Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
EE R + +KQ L+ G+ +EL E+ RL E+ KR+R+ E+ +Q+
Sbjct: 1751 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1807
Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
+ +++ + K E+E A+KEKE E ERLR L ++E ++R E + A+
Sbjct: 1808 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1867
Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
I+E + Q+ + +S L + K L +D R +R LE
Sbjct: 1868 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1924
Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
EL R +S E R K++ E E + + + + + EE ++K + E++ R++ +
Sbjct: 1925 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1984
Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
E+ERL+A++ E RR E + +E+ QL+ + Q+ + + + ++ +
Sbjct: 1985 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040
Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
E + T+ + V D LR + A
Sbjct: 2041 QELQQTLQQEQSVLDQLRGEAEA 2063
Score = 99.8 bits (247), Expect = 3e-20
Identities = 62/210 (29%), Positives = 109/210 (51%)
Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
L+ S IA + EK+S+ ++R ++ T LLEAQA +G ++ P ++L++
Sbjct: 2670 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2729
Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
+AV +GV+ ++ +L A++A G++ +++S +A+++ + E G R LE Q
Sbjct: 2730 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2789
Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
TGG++DP R+ + A R+G+ D + L D S K P T ++Y + R
Sbjct: 2790 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2849
Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
+ + TGL LL ++KG Y S A
Sbjct: 2850 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2879
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 964 bits (2491), Expect = 0.0
Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)
Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
+D +R+++TA L+E ++I T + L +G +S+ E A +L G GS+AG
Sbjct: 3626 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3685
Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
++ S+ +A +K L+S E +LLEAQAATG ++DP + E+LTVD A+ + L+ +
Sbjct: 3686 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3745
Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
++ +AE+A+TG+ DP++ +T+S+ +A+KK LI E +RLL+AQ+A+GG+VDP LP
Sbjct: 3746 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3805
Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
+VA RG +++D + L++P + +++VDP T +++SY QL RCR + TG LLL +
Sbjct: 3806 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3864
Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
R ++F+G+R+ +T+ ELV S ++ +T +L G S +EV + ++ FL+G+SCIAG+
Sbjct: 3865 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3924
Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
+ + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+ L+L VEEA + G+VG
Sbjct: 3925 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3984
Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 3985 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4044
Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4045 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4104
Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4105 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4164
Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
EEITI+ SDG + +++DR++G QYDI DAI K L+DR DQYR+G+LS+T+FADM+S
Sbjct: 4165 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4224
Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
G S S G SSS + +S + +S+SD EE+ P+A I
Sbjct: 4225 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4270
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++ + DAV++G++D+
Sbjct: 4271 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4330
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
M R+ AQKAF GFE + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+ G
Sbjct: 4331 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4390
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ +EA+++G +D R AQ+L+D +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4391 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4450
Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
EAA+ S+KG SPY++S SGS +GSR+GSR+GSR+GSRRGSFDATG+ +S +
Sbjct: 4451 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4502
Query: 2265 FSSSS 2269
FSSSS
Sbjct: 4503 FSSSS 4507
Score = 597 bits (1538), Expect = e-170
Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)
Query: 78 CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
C + L +A+ ++Q +++ G R+ E++ +A+ + +L + ++ ++ P
Sbjct: 394 CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 453
Query: 136 DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
+ +R+ +L E++ A L ++ P + A + Q ++ T
Sbjct: 454 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 510
Query: 188 TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
+ L W+ + + +D WGVDL SVE + SHRG+H SI ++R ++++ ++D + S
Sbjct: 511 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 570
Query: 247 --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
+ +L+ +Y LL +S R+ L L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 571 ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 630
Query: 299 SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
SD+NTN+ K+E++S M +LE+KEK++ +L+ D+L+ HPA +E++ LQTQW
Sbjct: 631 SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 690
Query: 359 SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
SW+LQ+ CI+ HLKENAAYFQFF + + E L+ LQ+++R+KY CD++ + L + +
Sbjct: 691 SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 750
Query: 419 KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
++ + E+E++ EYK + L ++K +VQLKPR+P + + L A+CDYKQ + VHK
Sbjct: 751 QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 810
Query: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
GDEC L + S W V G + VPSV ++PPPN A + ++E ++A++ LW+
Sbjct: 811 GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 870
Query: 539 QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
QL+++MKSL++W D++ IR+ ++A +T++ E+ + + LELHYQ F+R+SQ +
Sbjct: 871 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 930
Query: 599 MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
FG +D+ + ++ HYQ L+ L Q ++ CQ
Sbjct: 931 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 970
Query: 659 RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
+ EL+ IR Q+E CE R + LPL D+ + +I E + Q +
Sbjct: 971 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1020
Query: 716 --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
+ +A + + + +LA S L++E+ KLE + ++ YL L T+ +
Sbjct: 1021 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1080
Query: 774 LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
++ E++L+ +E +L E + V L ++EA + LKK++ ++ ++ EL+
Sbjct: 1081 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1140
Query: 834 KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
AQ++ + Q++ D+++ ++ E+V QL +RWQ + Q D R +LE+ +QLR YR+
Sbjct: 1141 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1200
Query: 894 NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
+ WL DA+RRQ+ +++M DS V L +++ L EI +K EE Q+ A+
Sbjct: 1201 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1260
Query: 954 CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
N+IKDYELQL +Y + LE + + P K+ +QS S ++QE D+ Y EL T + Y
Sbjct: 1261 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1319
Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
+F+SE L+ +E+ + + + + EE RLA + + + + + + Q K QAE
Sbjct: 1320 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1377
Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
+ + EE+ R +A +D + K+++ + Q+++ +E +I + E +R R +E
Sbjct: 1378 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1437
Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
+ + + ++ R + E + L + E+E ++ + E ERLR +Q+E RKR
Sbjct: 1438 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1497
Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
+ E ELA E+ + + +Q E L ++ + E+ + R ++++ L A+
Sbjct: 1498 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1557
Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
+ EAE + K+ EK Q++ L + ++ +EEA R+ + + E +ER + E
Sbjct: 1558 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1616
Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
+ER Q + + E + +++ +Q E E+ + + E + R+ Q E
Sbjct: 1617 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1676
Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
E ++ + + +G ++ A + +L +T +G++ + + E+ R A +
Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1731
Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
+ + + V A+ + L+ + E + LEA+A R
Sbjct: 1732 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1783
Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
+L ++A R L + RQ+ A E A
Sbjct: 1784 ELAEEAARLRALAEEAKRQRQLAEEDA 1810
Score = 528 bits (1359), Expect = e-149
Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)
Query: 997 ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
A + A L+ R D RFL E + ++ + + ++ V +E R E+ +
Sbjct: 2231 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2290
Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
+ L + + K + + Q +L A E L++Q EL + A++ + ++L E+
Sbjct: 2291 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2350
Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
+E E++R+ + ++ K ++ +A+ + + E +G + +E A
Sbjct: 2351 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2410
Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
+EK ++ L + Q+ + R RE EL + ++Q+ K++ Q VQ
Sbjct: 2411 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2470
Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
E++SLL + + +EQ+KA+L++L +DE+ +A+ E + R +Q++E E
Sbjct: 2471 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2530
Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
+Q++ + + + + EE +R+ + E ++ E+++ L E +RL+ +++ +EE+
Sbjct: 2531 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
R L S T SQ+ ++ + R G E + E FDGLR
Sbjct: 2591 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2636
Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
+KV+A +L E ++ L +L +G +V+E+A +++ +L+G SIAG + EK
Sbjct: 2637 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2696
Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
S+ A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+ ++ + ++ +A
Sbjct: 2697 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2756
Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S +P DVA
Sbjct: 2757 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2816
Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
RG D ++ R L DP D K F DP T + ++Y+QL ERC +P TGL LL +
Sbjct: 2817 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2876
Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
+K ++S FQG + VT+ E+++S R + + +G
Sbjct: 2877 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2934
Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
+I+ +++ + I ++ G C G +Y + + + +
Sbjct: 2935 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 2994
Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
+ ++ VR A+ LLEAQA TG I+
Sbjct: 2995 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3054
Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG +SLFQA+ K LI +
Sbjct: 3055 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3114
Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
G+RLL+AQ++TGGI+DP +SHR+P+D+A RG +EE S LS P D K + DP+T E
Sbjct: 3115 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3174
Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
TY +L++RC D+ TGL LLPL EK + + E E+ +E
Sbjct: 3175 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3219
Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
++K ++ WE I+ R L+ + + ++ I + +
Sbjct: 3220 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3279
Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
+ R LS + L+ V S + SGV S F + +V +S + SV
Sbjct: 3280 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3333
Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
R L L+ S +A I+ + EK+SI E + RG++ + T LLEAQA TG
Sbjct: 3334 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3383
Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
++ P Q+L + +AV GV+ ++ +L A+KA G+ +S +A+++ +
Sbjct: 3384 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3443
Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
+ G R LE Q TGG++DP R+ + A ++G+ + L D S K P T
Sbjct: 3444 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3503
Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
++Y+ + R + + TGLRLL
Sbjct: 3504 HENLTYRQLLERCVEDPETGLRLL 3527
Score = 419 bits (1078), Expect = e-116
Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)
Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
+Q ++ L Q++T E+ I+ I + E+ E++ + L + +E R
Sbjct: 2922 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2977
Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
RE QL+ ERS R E+D +R+ G++ E +++ L+K +
Sbjct: 2978 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3034
Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
A+ L E Q +D + +V+E V E L A P
Sbjct: 3035 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3094
Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
+ SL +A +K LI E + LL+AQ +TGGI+DP ++ ++ +D A AR +D +
Sbjct: 3095 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3154
Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
+ + A + DP +G+ + E ++ D+ TG+ LL L
Sbjct: 3155 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3198
Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
+ A AR +LY L +K V+ PV K V + E
Sbjct: 3199 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3255
Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
+ +E +L+ V++ +SF G+R PV +EL+ SG+L +
Sbjct: 3256 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3315
Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
+L+ G+ + ++ E ++ LQGS C+AGIY E TK+K+ IYEAM+ GL+R TA LL
Sbjct: 3316 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3375
Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
EAQAATGF+VDPV N RL V EA K G+VG E E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3376 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3435
Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
AM K L+ + HGIRLLEAQIATGGIIDP SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3436 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3495
Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
KGFFDPNT ENLTY QL ERC++D ETGL LLPLK EK + V+T+Q T + R +
Sbjct: 3496 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3555
Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
+ + MS+ E + LI E +L +++ +T R++++
Sbjct: 3556 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3607
Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
I + I+K + R + G S ++ ++D+
Sbjct: 3608 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3638
Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
F ++I ++ + L + S + LE S +A ++ + + +S
Sbjct: 3639 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3691
Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
I + +++G++ + + LLEAQA TG ++ P G++L++ +AV +G++ ++ RL A+
Sbjct: 3692 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3751
Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
+A G+ ++ +S +A+K++ +P E R L+ Q TGG+VDP + + E A +
Sbjct: 3752 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3811
Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
+G+++ +L + S + P T ++SY + R +D TG L L +A ++
Sbjct: 3812 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3870
Query: 2211 SKGLPSPYNM 2220
+GL M
Sbjct: 3871 FRGLRKQITM 3880
Score = 372 bits (956), Expect = e-102
Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)
Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
SF G+R+ V+ L ++GIL + L G + DE+ R ++ +LQG S IAG+ +
Sbjct: 2631 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2690
Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
T +KL +Y A++ L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E
Sbjct: 2691 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2750
Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
KLLSAERAVTGY DP TG ISLFQAM K LI + HGIRLLEAQIATGG+IDP SHR+
Sbjct: 2751 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2810
Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2811 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2870
Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
+K + +V D E ++ ++K + K + WE I
Sbjct: 2871 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2914
Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
R L+ + + ++ I ++ +Q + G L L++
Sbjct: 2915 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 2966
Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
V + + S V D +++ + SV ++ + +VR L ++ IA ++
Sbjct: 2967 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3016
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
E +K+SI +++ ++ S LLEAQA TG II P T +L++ +AV G++ +
Sbjct: 3017 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3076
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
+L A+KA G+ + +S +A+K+ +P E G R L+ Q TGG+VDP
Sbjct: 3077 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3136
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ + A +G +D ++ L + AK + P T +Y + R + +TGL LL
Sbjct: 3137 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3196
Query: 2205 EAASVSSK 2212
+ +++
Sbjct: 3197 PLSEKAAR 3204
Score = 259 bits (663), Expect = 2e-68
Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)
Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
D KL F GLRK++T +L Q++D+ T +L +G S+EEV +Q FL G IAG
Sbjct: 3865 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3924
Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
+ KE+ S+ +A +K +I P + LLEAQAATG +IDP + KLTV+ A+ ++
Sbjct: 3925 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3984
Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
+ + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP S
Sbjct: 3985 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4044
Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
LP +VA RGL D ++ L DP D K F DP T++ ++Y+QL ERC +P TGL L
Sbjct: 4045 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4104
Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
L + ++++ S +R + ++V E G++ T EL + +
Sbjct: 4105 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4164
Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
+E+ D + S I + + ++ I +A+ L+ R GT +
Sbjct: 4165 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4220
Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
+L A GF S+ P+ A R + V G D ET
Sbjct: 4221 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4277
Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
+S+ +AM++ L++ G RLLEAQ TGGIIDP R PV A +G ++ + + ++
Sbjct: 4278 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4337
Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
GF DP T+ ++ Q ++ E G L + Q T
Sbjct: 4338 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4382
Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
+++P+T + + EA ++G +D T ++L + G+ L KT +
Sbjct: 4383 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4429
Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
+DA+D+ +V+ + + T+ +G G+++ +G + SR
Sbjct: 4430 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4489
Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
S S ++T SSS+S +
Sbjct: 4490 GS---FDATGSGFSMTFSSSSYSSS 4511
Score = 111 bits (278), Expect = 7e-24
Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)
Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
E+++ + + + ++LEEEL RL R+A + K + L+ L K +AE A A
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1758
Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
EE R + +KQ L+ G+ +EL E+ RL E+ KR+R+ E+ +Q+
Sbjct: 1759 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1815
Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
+ +++ + K E+E A+KEKE E ERLR L ++E ++R E + A+
Sbjct: 1816 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1875
Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
I+E + Q+ + +S L + K L +D R +R LE
Sbjct: 1876 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1932
Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
EL R +S E R K++ E E + + + + + EE ++K + E++ R++ +
Sbjct: 1933 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1992
Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
E+ERL+A++ E RR E + +E+ QL+ + Q+ + + + ++ +
Sbjct: 1993 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2048
Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
E + T+ + V D LR + A
Sbjct: 2049 QELQQTLQQEQSVLDQLRGEAEA 2071
Score = 99.8 bits (247), Expect = 3e-20
Identities = 62/210 (29%), Positives = 109/210 (51%)
Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
L+ S IA + EK+S+ ++R ++ T LLEAQA +G ++ P ++L++
Sbjct: 2678 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2737
Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
+AV +GV+ ++ +L A++A G++ +++S +A+++ + E G R LE Q
Sbjct: 2738 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2797
Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
TGG++DP R+ + A R+G+ D + L D S K P T ++Y + R
Sbjct: 2798 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2857
Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
+ + TGL LL ++KG Y S A
Sbjct: 2858 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2887
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 964 bits (2491), Expect = 0.0
Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)
Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
+D +R+++TA L+E ++I T + L +G +S+ E A +L G GS+AG
Sbjct: 3667 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3726
Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
++ S+ +A +K L+S E +LLEAQAATG ++DP + E+LTVD A+ + L+ +
Sbjct: 3727 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3786
Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
++ +AE+A+TG+ DP++ +T+S+ +A+KK LI E +RLL+AQ+A+GG+VDP LP
Sbjct: 3787 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3846
Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
+VA RG +++D + L++P + +++VDP T +++SY QL RCR + TG LLL +
Sbjct: 3847 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3905
Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
R ++F+G+R+ +T+ ELV S ++ +T +L G S +EV + ++ FL+G+SCIAG+
Sbjct: 3906 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3965
Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
+ + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+ L+L VEEA + G+VG
Sbjct: 3966 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4025
Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 4026 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4085
Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4086 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4145
Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4146 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4205
Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
EEITI+ SDG + +++DR++G QYDI DAI K L+DR DQYR+G+LS+T+FADM+S
Sbjct: 4206 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4265
Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
G S S G SSS + +S + +S+SD EE+ P+A I
Sbjct: 4266 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4311
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++ + DAV++G++D+
Sbjct: 4312 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4371
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
M R+ AQKAF GFE + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+ G
Sbjct: 4372 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4431
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ +EA+++G +D R AQ+L+D +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4432 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4491
Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
EAA+ S+KG SPY++S SGS +GSR+GSR+GSR+GSRRGSFDATG+ +S +
Sbjct: 4492 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4543
Query: 2265 FSSSS 2269
FSSSS
Sbjct: 4544 FSSSS 4548
Score = 597 bits (1538), Expect = e-170
Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)
Query: 78 CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
C + L +A+ ++Q +++ G R+ E++ +A+ + +L + ++ ++ P
Sbjct: 435 CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 494
Query: 136 DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
+ +R+ +L E++ A L ++ P + A + Q ++ T
Sbjct: 495 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 551
Query: 188 TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
+ L W+ + + +D WGVDL SVE + SHRG+H SI ++R ++++ ++D + S
Sbjct: 552 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 611
Query: 247 --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
+ +L+ +Y LL +S R+ L L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 612 ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 671
Query: 299 SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
SD+NTN+ K+E++S M +LE+KEK++ +L+ D+L+ HPA +E++ LQTQW
Sbjct: 672 SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 731
Query: 359 SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
SW+LQ+ CI+ HLKENAAYFQFF + + E L+ LQ+++R+KY CD++ + L + +
Sbjct: 732 SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 791
Query: 419 KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
++ + E+E++ EYK + L ++K +VQLKPR+P + + L A+CDYKQ + VHK
Sbjct: 792 QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 851
Query: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
GDEC L + S W V G + VPSV ++PPPN A + ++E ++A++ LW+
Sbjct: 852 GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 911
Query: 539 QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
QL+++MKSL++W D++ IR+ ++A +T++ E+ + + LELHYQ F+R+SQ +
Sbjct: 912 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 971
Query: 599 MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
FG +D+ + ++ HYQ L+ L Q ++ CQ
Sbjct: 972 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 1011
Query: 659 RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
+ EL+ IR Q+E CE R + LPL D+ + +I E + Q +
Sbjct: 1012 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1061
Query: 716 --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
+ +A + + + +LA S L++E+ KLE + ++ YL L T+ +
Sbjct: 1062 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1121
Query: 774 LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
++ E++L+ +E +L E + V L ++EA + LKK++ ++ ++ EL+
Sbjct: 1122 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1181
Query: 834 KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
AQ++ + Q++ D+++ ++ E+V QL +RWQ + Q D R +LE+ +QLR YR+
Sbjct: 1182 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1241
Query: 894 NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
+ WL DA+RRQ+ +++M DS V L +++ L EI +K EE Q+ A+
Sbjct: 1242 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1301
Query: 954 CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
N+IKDYELQL +Y + LE + + P K+ +QS S ++QE D+ Y EL T + Y
Sbjct: 1302 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1360
Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
+F+SE L+ +E+ + + + + EE RLA + + + + + + Q K QAE
Sbjct: 1361 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1418
Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
+ + EE+ R +A +D + K+++ + Q+++ +E +I + E +R R +E
Sbjct: 1419 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1478
Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
+ + + ++ R + E + L + E+E ++ + E ERLR +Q+E RKR
Sbjct: 1479 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1538
Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
+ E ELA E+ + + +Q E L ++ + E+ + R ++++ L A+
Sbjct: 1539 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1598
Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
+ EAE + K+ EK Q++ L + ++ +EEA R+ + + E +ER + E
Sbjct: 1599 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1657
Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
+ER Q + + E + +++ +Q E E+ + + E + R+ Q E
Sbjct: 1658 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1717
Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
E ++ + + +G ++ A + +L +T +G++ + + E+ R A +
Sbjct: 1718 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1772
Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
+ + + V A+ + L+ + E + LEA+A R
Sbjct: 1773 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1824
Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
+L ++A R L + RQ+ A E A
Sbjct: 1825 ELAEEAARLRALAEEAKRQRQLAEEDA 1851
Score = 528 bits (1359), Expect = e-149
Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)
Query: 997 ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
A + A L+ R D RFL E + ++ + + ++ V +E R E+ +
Sbjct: 2272 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2331
Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
+ L + + K + + Q +L A E L++Q EL + A++ + ++L E+
Sbjct: 2332 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2391
Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
+E E++R+ + ++ K ++ +A+ + + E +G + +E A
Sbjct: 2392 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2451
Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
+EK ++ L + Q+ + R RE EL + ++Q+ K++ Q VQ
Sbjct: 2452 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2511
Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
E++SLL + + +EQ+KA+L++L +DE+ +A+ E + R +Q++E E
Sbjct: 2512 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2571
Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
+Q++ + + + + EE +R+ + E ++ E+++ L E +RL+ +++ +EE+
Sbjct: 2572 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
R L S T SQ+ ++ + R G E + E FDGLR
Sbjct: 2632 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2677
Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
+KV+A +L E ++ L +L +G +V+E+A +++ +L+G SIAG + EK
Sbjct: 2678 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2737
Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
S+ A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+ ++ + ++ +A
Sbjct: 2738 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2797
Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S +P DVA
Sbjct: 2798 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2857
Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
RG D ++ R L DP D K F DP T + ++Y+QL ERC +P TGL LL +
Sbjct: 2858 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2917
Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
+K ++S FQG + VT+ E+++S R + + +G
Sbjct: 2918 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2975
Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
+I+ +++ + I ++ G C G +Y + + + +
Sbjct: 2976 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 3035
Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
+ ++ VR A+ LLEAQA TG I+
Sbjct: 3036 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3095
Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG +SLFQA+ K LI +
Sbjct: 3096 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3155
Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
G+RLL+AQ++TGGI+DP +SHR+P+D+A RG +EE S LS P D K + DP+T E
Sbjct: 3156 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3215
Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
TY +L++RC D+ TGL LLPL EK + + E E+ +E
Sbjct: 3216 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3260
Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
++K ++ WE I+ R L+ + + ++ I + +
Sbjct: 3261 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3320
Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
+ R LS + L+ V S + SGV S F + +V +S + SV
Sbjct: 3321 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3374
Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
R L L+ S +A I+ + EK+SI E + RG++ + T LLEAQA TG
Sbjct: 3375 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3424
Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
++ P Q+L + +AV GV+ ++ +L A+KA G+ +S +A+++ +
Sbjct: 3425 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3484
Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
+ G R LE Q TGG++DP R+ + A ++G+ + L D S K P T
Sbjct: 3485 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3544
Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
++Y+ + R + + TGLRLL
Sbjct: 3545 HENLTYRQLLERCVEDPETGLRLL 3568
Score = 419 bits (1078), Expect = e-116
Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)
Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
+Q ++ L Q++T E+ I+ I + E+ E++ + L + +E R
Sbjct: 2963 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 3018
Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
RE QL+ ERS R E+D +R+ G++ E +++ L+K +
Sbjct: 3019 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3075
Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
A+ L E Q +D + +V+E V E L A P
Sbjct: 3076 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3135
Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
+ SL +A +K LI E + LL+AQ +TGGI+DP ++ ++ +D A AR +D +
Sbjct: 3136 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3195
Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
+ + A + DP +G+ + E ++ D+ TG+ LL L
Sbjct: 3196 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3239
Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
+ A AR +LY L +K V+ PV K V + E
Sbjct: 3240 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3296
Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
+ +E +L+ V++ +SF G+R PV +EL+ SG+L +
Sbjct: 3297 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3356
Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
+L+ G+ + ++ E ++ LQGS C+AGIY E TK+K+ IYEAM+ GL+R TA LL
Sbjct: 3357 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3416
Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
EAQAATGF+VDPV N RL V EA K G+VG E E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3417 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3476
Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
AM K L+ + HGIRLLEAQIATGGIIDP SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3477 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3536
Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
KGFFDPNT ENLTY QL ERC++D ETGL LLPLK EK + V+T+Q T + R +
Sbjct: 3537 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3596
Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
+ + MS+ E + LI E +L +++ +T R++++
Sbjct: 3597 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3648
Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
I + I+K + R + G S ++ ++D+
Sbjct: 3649 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3679
Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
F ++I ++ + L + S + LE S +A ++ + + +S
Sbjct: 3680 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3732
Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
I + +++G++ + + LLEAQA TG ++ P G++L++ +AV +G++ ++ RL A+
Sbjct: 3733 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3792
Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
+A G+ ++ +S +A+K++ +P E R L+ Q TGG+VDP + + E A +
Sbjct: 3793 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3852
Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
+G+++ +L + S + P T ++SY + R +D TG L L +A ++
Sbjct: 3853 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3911
Query: 2211 SKGLPSPYNM 2220
+GL M
Sbjct: 3912 FRGLRKQITM 3921
Score = 372 bits (956), Expect = e-102
Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)
Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
SF G+R+ V+ L ++GIL + L G + DE+ R ++ +LQG S IAG+ +
Sbjct: 2672 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2731
Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
T +KL +Y A++ L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E
Sbjct: 2732 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2791
Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
KLLSAERAVTGY DP TG ISLFQAM K LI + HGIRLLEAQIATGG+IDP SHR+
Sbjct: 2792 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2851
Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2852 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2911
Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
+K + +V D E ++ ++K + K + WE I
Sbjct: 2912 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2955
Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
R L+ + + ++ I ++ +Q + G L L++
Sbjct: 2956 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 3007
Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
V + + S V D +++ + SV ++ + +VR L ++ IA ++
Sbjct: 3008 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3057
Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
E +K+SI +++ ++ S LLEAQA TG II P T +L++ +AV G++ +
Sbjct: 3058 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3117
Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
+L A+KA G+ + +S +A+K+ +P E G R L+ Q TGG+VDP
Sbjct: 3118 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3177
Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
R+ + A +G +D ++ L + AK + P T +Y + R + +TGL LL
Sbjct: 3178 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3237
Query: 2205 EAASVSSK 2212
+ +++
Sbjct: 3238 PLSEKAAR 3245
Score = 259 bits (663), Expect = 2e-68
Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)
Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
D KL F GLRK++T +L Q++D+ T +L +G S+EEV +Q FL G IAG
Sbjct: 3906 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3965
Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
+ KE+ S+ +A +K +I P + LLEAQAATG +IDP + KLTV+ A+ ++
Sbjct: 3966 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4025
Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
+ + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP S
Sbjct: 4026 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4085
Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
LP +VA RGL D ++ L DP D K F DP T++ ++Y+QL ERC +P TGL L
Sbjct: 4086 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4145
Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
L + ++++ S +R + ++V E G++ T EL + +
Sbjct: 4146 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4205
Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
+E+ D + S I + + ++ I +A+ L+ R GT +
Sbjct: 4206 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4261
Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
+L A GF S+ P+ A R + V G D ET
Sbjct: 4262 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4318
Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
+S+ +AM++ L++ G RLLEAQ TGGIIDP R PV A +G ++ + + ++
Sbjct: 4319 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4378
Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
GF DP T+ ++ Q ++ E G L + Q T
Sbjct: 4379 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4423
Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
+++P+T + + EA ++G +D T ++L + G+ L KT +
Sbjct: 4424 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4470
Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
+DA+D+ +V+ + + T+ +G G+++ +G + SR
Sbjct: 4471 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4530
Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
S S ++T SSS+S +
Sbjct: 4531 GS---FDATGSGFSMTFSSSSYSSS 4552
Score = 111 bits (278), Expect = 7e-24
Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)
Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
E+++ + + + ++LEEEL RL R+A + K + L+ L K +AE A A
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1799
Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
EE R + +KQ L+ G+ +EL E+ RL E+ KR+R+ E+ +Q+
Sbjct: 1800 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1856
Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
+ +++ + K E+E A+KEKE E ERLR L ++E ++R E + A+
Sbjct: 1857 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1916
Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
I+E + Q+ + +S L + K L +D R +R LE
Sbjct: 1917 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1973
Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
EL R +S E R K++ E E + + + + + EE ++K + E++ R++ +
Sbjct: 1974 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2033
Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
E+ERL+A++ E RR E + +E+ QL+ + Q+ + + + ++ +
Sbjct: 2034 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2089
Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
E + T+ + V D LR + A
Sbjct: 2090 QELQQTLQQEQSVLDQLRGEAEA 2112
Score = 99.8 bits (247), Expect = 3e-20
Identities = 62/210 (29%), Positives = 109/210 (51%)
Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
L+ S IA + EK+S+ ++R ++ T LLEAQA +G ++ P ++L++
Sbjct: 2719 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2778
Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
+AV +GV+ ++ +L A++A G++ +++S +A+++ + E G R LE Q
Sbjct: 2779 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2838
Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
TGG++DP R+ + A R+G+ D + L D S K P T ++Y + R
Sbjct: 2839 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2898
Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
+ + TGL LL ++KG Y S A
Sbjct: 2899 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2928
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 606 bits (1562), Expect = e-173
Identities = 368/1259 (29%), Positives = 657/1259 (52%), Gaps = 139/1259 (11%)
Query: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
+E + L W+ + + ++D WG DL SVE H+ +H+ +H +I ++ L + K
Sbjct: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
Query: 241 DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
+ +A +++LE +Y LL S + HL L N + + E++W+N+ EE
Sbjct: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
Query: 292 EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
EE+ YDWS++NTNIA+K++ + M +L+ KE+ + +++ ++QL+L HPA IEAY
Sbjct: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
Query: 352 DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
+QTQWSWILQ+ +C++ H+KEN AYF+FF +A+ YL+ L+D+I++KY CD++ +
Sbjct: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
Query: 412 QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
L + ++E +E+E++L+YK + NL+ K+K I+QLKPRN D I ++A+CDY+Q
Sbjct: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
Query: 472 DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
+ ++K DEC+L +N+ R+KW V P G + +VPSV +PPPN AVDL+ +IEQ Y+
Sbjct: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
Query: 532 AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
+L LW++ +INMKS+VSWHY + +I++IRA +A +KTM ++ + +++L+ +++F+
Sbjct: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
Query: 592 RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
+SQ S++F D +++ + +++YQ L+
Sbjct: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 726
Query: 652 NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
K E + + + E++ IR ++E+CE R+ + ++ H +I E +
Sbjct: 727 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785
Query: 712 VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
++ + + + + + N+ ++ + S L++E+ + Q + + ++ Y++ L
Sbjct: 786 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845
Query: 768 CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
TV +L+ E ++K+YE +L EEE V D + +E LK+ +++++ K+ +
Sbjct: 846 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 905
Query: 828 MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
++ ELQKA+ I + + Y DLD EK QL +RWQ + QID RL DLE K
Sbjct: 906 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 965
Query: 888 LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
L+ YRD Y W+ + Q ++ + +S T+ LN+QK L SEI K+ K +E
Sbjct: 966 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025
Query: 948 QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
QK AE + ++KDYELQ +Y + +++ P+KR +QS + +I+QE D+ RY L+
Sbjct: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085
Query: 1008 TRSGDYYRFLSEMLKSLEDLKLK------------------------NTKI--------- 1034
T Y +F + LK LE+ ++K N+K+
Sbjct: 1086 TLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELER 1145
Query: 1035 ---------EVLEEELRLARDANSENCNKNK--FLDQNLQKYQA--ECSQFKAKLASLEE 1081
+EEEL R+A K + D +LQK +A E Q++ +L ++
Sbjct: 1146 MVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVR 1205
Query: 1082 LKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR---------- 1131
K AE + + +Q + + + E + ++E+ R+++ED
Sbjct: 1206 EKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLND 1265
Query: 1132 FDQQKND-YDQLQKARQCEKE----------NLGWQKLESEKAIKEKE-YEIERLRVLLQ 1179
+QQKN ++L++ R E+E +L +QK +EK +KEK+ E+E R + +
Sbjct: 1266 LEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITE 1325
Query: 1180 EEGTRKREYENEL----------AKASNRIQE--SKNQCTQVVQERESLLVKIKVLEQDK 1227
+ T + EN L +A +Q+ K + ++ Q+ + L + EQD
Sbjct: 1326 IQYTCR---ENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDM 1382
Query: 1228 ARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESERE 1287
L + L K++ E + R+ L+ + + N L K + RK++A + +
Sbjct: 1383 RELTYELNALQLEKTSSEEKARL---LKDKLDETNNTLRCLKLELERKDQAEKGYSQQLR 1439
Query: 1288 KSEREKNSLRSEIERLQAE---IKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKL 1343
+ R+ N + E E +K+I+ + +LE L E+ + QRE+D++
Sbjct: 1440 ELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELE--------SLNHEKGKLQREVDRI 1490
Score = 377 bits (969), Expect = e-104
Identities = 218/619 (35%), Positives = 346/619 (55%), Gaps = 50/619 (8%)
Query: 1603 SVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA 1662
SV+ FQG+R VT +LV++ +L T+ +L G + +EV + + FL ++ IA
Sbjct: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIA 2140
Query: 1663 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 1722
G+Y E+TK+K+ A + ++ AL LEAQAATGFI+DP+S VE+A +G+V
Sbjct: 2141 GLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVV 2200
Query: 1723 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 1782
EF+ +LL AE+A GY+ + +S+FQAM ++++ G +LEAQIA+GG+IDP
Sbjct: 2201 DPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPV 2258
Query: 1783 ESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGL 1842
R+P +IA ++G N + + L +PS +T+ F +PN ++ L Y +L C+ D E+
Sbjct: 2259 RGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQC 2318
Query: 1843 CLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQEC 1902
L P E+ S N + R+ +VD +T E++V EA+++ LI+ + EL Q+
Sbjct: 2319 FLFPFGERN----ISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQY 2374
Query: 1903 EWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMI 1962
+W+E S G + +L D KTG ++I +AI++G +D+ +Y+ G ++LT+ AD
Sbjct: 2375 QWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELAD-- 2432
Query: 1963 SLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2022
S +S + ++L SP+A
Sbjct: 2433 -----------------------------SLLSRLVPKKDL-------------HSPVAG 2450
Query: 2023 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2082
+ T + E+IS+ + R +VD IT R LEAQ TGGII P TG+K + +A+ +G++D
Sbjct: 2451 YWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVD 2510
Query: 2083 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2142
+ A +L+ + G K MS EAV + E G R LEFQYLTGGL++P+V
Sbjct: 2511 EGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQV 2570
Query: 2143 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2202
H R+S EEA++ G ID A +L+D SY + + CP+TK K++YK+A+ ++ + TGL+
Sbjct: 2571 HSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLK 2630
Query: 2203 LLEAASVSSKGLPSPYNMS 2221
LLE + G+ S Y S
Sbjct: 2631 LLEVSEPLMTGISSLYYSS 2649
Score = 272 bits (696), Expect = 2e-72
Identities = 324/1404 (23%), Positives = 588/1404 (41%), Gaps = 264/1404 (18%)
Query: 647 QDVNHNKVIETNRENDKQETWMLMELQKIRR--QIEHCEGRMTLKNLPLADQGSSHHITV 704
+D+ K + + +KQ+ +EL+ R+ +I++ L P+ S +T
Sbjct: 1296 KDLAFQKQVAEKQLKEKQK----IELEARRKITEIQYTCRENALPVCPITQATSCRAVTG 1351
Query: 705 KINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYL 764
E +D Q E+ Q+ ++ A R +E+ + + +N +
Sbjct: 1352 LQQE-----HDKQKAEELKQQVDELTAANRKAEQ---------DMRELTYELNALQLEKT 1397
Query: 765 NSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSL 824
+S R L + +T + L+ + L ++ + Y L+++ LN
Sbjct: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQA------EKGYSQQLRELGRQLNQTTGK 1451
Query: 825 LATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQ 884
E ++I + + + GK +V ++T +K I L Q
Sbjct: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQH----LNSQ 1507
Query: 885 IKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKS 944
I R+ ++ + L +R+ D L+ +++ + +K + +I ++
Sbjct: 1508 IHSFRDEKE-----LERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEEL 1562
Query: 945 EEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYI 1004
E+ + AE+ +++ Q ET L + IQ+ S I+ E + R
Sbjct: 1563 EKSNECAEMLKQKVEELTRQ------NNETKLMMQ----RIQAESENIVLEKQTIQQR-C 1611
Query: 1005 ELLTRSGDYYRFLSEMLKSLEDLKLKNTK--------IEVLEEELRLARDANSE---NCN 1053
E L D ++ + L+S + K TK I+ LEE+L +++ SE C+
Sbjct: 1612 EALKIQADGFK---DQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCD 1668
Query: 1054 KNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITR 1113
+ + QN +K E A+L + +E KR+ E Q + Q++ELN ++ +
Sbjct: 1669 QQNIIIQNTKK---EVRNLNAELNASKEEKRRGE-------QKVQLQQAQVQELNNRLKK 1718
Query: 1114 LTYE-----IEDEKRRRKSV-----EDRFDQQKNDY----DQLQKARQCEKENLGWQKLE 1159
+ E IE++ RK V +F Q ++ ++L +++ + ++ +L+
Sbjct: 1719 VQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLD 1778
Query: 1160 -----------------SEKAIKEKEYEIERLRVLLQE-------EGTRKREYENELAKA 1195
E IKE E ++++ R +Q+ + ++ E+EL
Sbjct: 1779 FVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQ 1838
Query: 1196 SNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR------LEDELNRAKSTLEAETR 1249
++ K + Q ++E E LV ++ Q K+ + E + + + E +R
Sbjct: 1839 KREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSR 1898
Query: 1250 VKQRLECEKQQIQNDLNQW---------KTQYSRKEEAIRKIES-------EREKSEREK 1293
L + + L +W K Q+ E+ ++++ E+EKS++
Sbjct: 1899 NTGHLHPTPR---SPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCY 1955
Query: 1294 NSLRSE--------------IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE 1339
+ S+ I RL +EI++I ++ R + E E +
Sbjct: 1956 SEYFSQTSTELQITFDETNPITRL-SEIEKIRDQALNNSRPPVRYQDNACEMELVKVLTP 2014
Query: 1340 IDKLRQRPYGSHRETQT----------ECEW----------------------------- 1360
++ + + Y H E T EW
Sbjct: 2015 LEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNF 2074
Query: 1361 ------TVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLR 1414
+V + F GLR VTA QL E +L+D T+++L G K+VEEV + FL
Sbjct: 2075 DGDHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLT 2134
Query: 1415 GAGSIAGASA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSA 1473
A SIAG S KEK S A + +I + LEAQAATG IIDP + +V+ A
Sbjct: 2135 KATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDA 2194
Query: 1474 IARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASG 1533
+ + ++D + R ++ AEKA G+ +S KT+SV +A++ ++DR+ G +LEAQIASG
Sbjct: 2195 VLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASG 2252
Query: 1534 GVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVD------------------ 1575
GV+DPV + +P ++AL +GL++ + + L++P + + F +
Sbjct: 2253 GVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVF 2312
Query: 1576 ---------PVTKKKVSYVQLKERCRI---EPHTG------------------LLLLSVQ 1605
P ++ +S + +K+ RI + TG L LS Q
Sbjct: 2313 DVESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQ 2372
Query: 1606 ----KRSMSFQGIRQP------------VTVTELVDSGILRPSTVNELESGQISYDEVGE 1649
K +M F+ + E ++ G + + V + + G I+ E+ +
Sbjct: 2373 QYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELAD 2432
Query: 1650 RIKDFLQGS----SCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDP 1705
+ L S +AG + + +++ + +A + LV TAL LEAQ +TG I+DP
Sbjct: 2433 SLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDP 2492
Query: 1706 VSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHG 1765
++ + V EA RGLV F ++L E +TG P T ++S+ +A+N +I K G
Sbjct: 2493 LTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMG 2552
Query: 1766 IRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENL 1825
IR LE Q TGG+I+P+ RL ++ A + G + ++ L D + P T+ L
Sbjct: 2553 IRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKL 2612
Query: 1826 TYLQLKERCIKDEETGLCLLPLKE 1849
TY + E+ D TGL LL + E
Sbjct: 2613 TYKEALEKADFDFHTGLKLLEVSE 2636
Score = 124 bits (311), Expect = 1e-27
Identities = 93/289 (32%), Positives = 145/289 (50%), Gaps = 12/289 (4%)
Query: 1324 ETQSQLETERSRYQ-REIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLY 1382
E LE +YQ +E + SH T T+ + ++ + G K + Y
Sbjct: 2362 EKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKK-Y 2420
Query: 1383 ECQLIDKTTL-DKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLI 1441
+ LI T L D LL +++ S + AG AS E+ S+++A R+ L+
Sbjct: 2421 QEGLITLTELADSLLSRLVPKKDLHSPV------AGYWLTASG---ERISVLKASRRNLV 2471
Query: 1442 SPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPF 1501
+ + LEAQ +TGGIIDP +K V A+ R L+D QQ+ E ITG P
Sbjct: 2472 DRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPI 2531
Query: 1502 SGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYR 1561
+ K +SV EA+ N+I++E G+R LE Q +GG+++P L + AL G+ID +
Sbjct: 2532 TNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIAT 2591
Query: 1562 SLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMS 1610
L D + +N + P TK+K++Y + E+ + HTGL LL V + M+
Sbjct: 2592 KLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMT 2640
Score = 60.5 bits (145), Expect = 2e-08
Identities = 124/635 (19%), Positives = 259/635 (40%), Gaps = 112/635 (17%)
Query: 909 QDSLESMKFGDSNTVM--RFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966
+DS ES F S+ + +N K + E+ ++ E+ + + L + +++ L+L
Sbjct: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
Query: 967 SYTSGLETLLNIPIKRTMI-QSPSGVILQEAADVHARYI--ELLTRSGDYYRFLSEMLKS 1023
+ L + P++R + +S + QE + +L T + F S+ S
Sbjct: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
Query: 1024 LEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELK 1083
L++ ++ V+ + + +S +K K ++ L+ QA ++ KL + +
Sbjct: 815 SSVPTLRS-ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA--AEALVKLYETKLCE 871
Query: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR-----------F 1132
+A + K+ +NL Q + ++ ++ + +EDE ++ K++ D F
Sbjct: 872 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF 931
Query: 1133 DQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVL---LQEEGTRKREYE 1189
D K DQL + Q + + + E K +Y + L +Q+ T +R+ +
Sbjct: 932 DWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
Query: 1190 NELAKASNRIQESKNQCTQVVQERESLLVKI----KVLEQDKARLQRLEDELNRAKSTLE 1245
+ S + NQ +V E E K+ K EQ A ++ E + ++ ++
Sbjct: 992 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1051
Query: 1246 AETRV---KQRLECEKQQIQNDLNQWKTQYSR-------------------KEEAIRKIE 1283
++ + ++R++ I + +T+Y+ +EE I++ +
Sbjct: 1052 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCK 1111
Query: 1284 S-----------EREKSEREKNSLR----SEIERLQAEIK----RIEE---RCRRKLEDS 1321
+R+K+ +NS SE+ER+ AE+K R+EE + R E+
Sbjct: 1112 ETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENE 1171
Query: 1322 TRETQSQLE----------TERSRYQREIDKLRQRPYGSHRETQTECEWTVD-------- 1363
R+ Q +E +E +Y+RE++ + + + RE + + T++
Sbjct: 1172 LRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAV 1231
Query: 1364 ----------------TSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEE--- 1404
T + + D L++K ++ E Q K L + L+ K+ EE
Sbjct: 1232 EENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQ---KNKLMEELRRKRDNEEELL 1288
Query: 1405 -VASEIQPFLRGAGSIAGASASPKEKYSLVEAKRK 1438
+ +++ L +A K+K L EA+RK
Sbjct: 1289 KLIKQMEKDLAFQKQVAEKQLKEKQKIEL-EARRK 1322
Score = 37.4 bits (85), Expect = 0.17
Identities = 58/248 (23%), Positives = 111/248 (44%), Gaps = 48/248 (19%)
Query: 216 QHINSHRGIHNSIGDYRWQLDKIKADLREKSAIY-QLEEEYENLL---KASFERMDHLRQ 271
QH+NS IH S D + +L++++ R+ + Q E+ +E LL KA E D +++
Sbjct: 1502 QHLNSQ--IH-SFRDEK-ELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQR 1557
Query: 272 LQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQ 331
L ++ + N+C E + QK E + + ++ ++ + +++
Sbjct: 1558 LNEELEKS-------NECAEM------------LKQKVEELTRQNNETKLM---MQRIQA 1595
Query: 332 ESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFE-EAQSTEA 390
ES+ +VL + + EA L+ Q + + HL + Q F+ + + E
Sbjct: 1596 ESENIVLEKQTIQQRCEA----LKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEE 1651
Query: 391 YLKGLQDSIRK-KYPCDK-NMPLQHLLEQIKELEKEREKILEYKR-----------QVQN 437
L Q+ + + K CD+ N+ +Q+ ++++ L E E KR QVQ
Sbjct: 1652 DLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQE 1711
Query: 438 LVNKSKKI 445
L N+ KK+
Sbjct: 1712 LNNRLKKV 1719
>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
Length = 3062
Score = 596 bits (1537), Expect = e-170
Identities = 394/1408 (27%), Positives = 706/1408 (50%), Gaps = 116/1408 (8%)
Query: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
+E + L W+ + + ++D WG DL SVE H+ +H+ +H +I ++ L + K
Sbjct: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
Query: 241 DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
+ +A +++LE +Y LL S + HL L N + + E++W+N+ EE
Sbjct: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
Query: 292 EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
EE+ YDWS++NTNIA+K++ + M +L+ KE+ + +++ ++QL+L HPA IEAY
Sbjct: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
Query: 352 DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
+QTQWSWILQ+ +C++ H+KEN AYF+FF +A+ YL+ L+D+I++KY CD++ +
Sbjct: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
Query: 412 QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
L + ++E +E+E++L+YK + NL+ K+K I+QLKPRN D I ++A+CDY+Q
Sbjct: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
Query: 472 DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
+ ++K DEC+L +N+ R+KW V P G + +VPSV +PPPN AVDL+ +IEQ Y+
Sbjct: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
Query: 532 AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
+L LW++ +INMKS+VSWHY + +I++IRA +A +KTM ++ + +++L+ +++F+
Sbjct: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
Query: 592 RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
+SQ S++F D +++ + +++YQ L+
Sbjct: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 726
Query: 652 NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
K E + + + E++ IR ++E+CE R+ + ++ H +I E +
Sbjct: 727 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785
Query: 712 VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
++ + + + + + N+ ++ + S L++E+ + Q + + ++ Y++ L
Sbjct: 786 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845
Query: 768 CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
TV +L+ E ++K+YE +L EEE V D + +E LK+ +++++ K+ +
Sbjct: 846 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 905
Query: 828 MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
++ ELQKA+ I + + Y DLD EK QL +RWQ + QID RL DLE K
Sbjct: 906 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 965
Query: 888 LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
L+ YRD Y W+ + Q ++ + +S T+ LN+QK L SEI K+ K +E
Sbjct: 966 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025
Query: 948 QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
QK AE + ++KDYELQ +Y + +++ P+KR +QS + +I+QE D+ RY L+
Sbjct: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085
Query: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLEEELRLARDA--------NSENCNKNKF 1057
T Y +F + LK L E+ L+ K E +E+ L + ++E K F
Sbjct: 1086 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1145
Query: 1058 LDQNLQKYQAECSQFKAKLA-SLEELKR-QAELDGKSAKQNLDKCYGQIKELNEKITRLT 1115
Q + E S K +L+ +L+ ++ A+ K + ++ Q+K L E L
Sbjct: 1146 SKQKIS--SEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLF 1203
Query: 1116 YEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLR 1175
E + + ++ D ++K L K + + L +A+ LR
Sbjct: 1204 SESLKQLQESQTSGDVKVEEK-----LDKVIAGTIDQTTGEVLSVFQAV---------LR 1249
Query: 1176 VLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLED 1235
L+ + T R E +L S I +C + + L+ ++L Q K
Sbjct: 1250 GLIDYD-TGIRLLETQL-MISGLISPELRKCFDLKDAKSHGLIDEQILCQLK-------- 1299
Query: 1236 ELNRAKSTLEAETRVK-QRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKN 1294
EL++AK + A + L+ Q + + K I + E+ +K
Sbjct: 1300 ELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKA 1359
Query: 1295 SLRSEI-ERLQAEIKRIEERCRRKLEDSTRETQSQLE-TERSRYQREIDK--LRQRPYGS 1350
++ + L +++ + C+ ++ T E S ++ +RS Q L RP
Sbjct: 1360 FQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEG 1419
Query: 1351 HRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQ 1410
R T +C + + +GL + T +L QL+
Sbjct: 1420 GRIT-LKCGRNISILRAAHEGLIDRETMFRLLSAQLL----------------------- 1455
Query: 1411 PFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTV 1470
+G + +++ ++ ++ EA R+ +I ++ +L Q TGGII + ++LTV
Sbjct: 1456 -----SGGLINSNSG--QRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTV 1508
Query: 1471 DSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQI 1530
D A+ DLI + A++ G P SG+ S ++++ LI E ++L +
Sbjct: 1509 DEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQ 1568
Query: 1531 ASGGVVDPVNSVFLPKDVALARGLIDRD 1558
+ P +S + D A G+ID +
Sbjct: 1569 KIAALYIPESSQVIGLDAAKQLGIIDNN 1596
Score = 150 bits (378), Expect = 2e-35
Identities = 188/946 (19%), Positives = 400/946 (42%), Gaps = 83/946 (8%)
Query: 909 QDSLESMKFGDSNTVM--RFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966
+DS ES F S+ + +N K + E+ ++ E+ + + L + +++ L+L
Sbjct: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
Query: 967 SYTSGLETLLNIPIKRTMI-QSPSGVILQEAADVHARYI--ELLTRSGDYYRFLSEMLKS 1023
+ L + P++R + +S + QE + +L T + F S+ S
Sbjct: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814
Query: 1024 LEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELK 1083
L++ ++ V+ + + +S +K K ++ L+ QA ++ KL + +
Sbjct: 815 SSVPTLRS-ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA--AEALVKLYETKLCE 871
Query: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR-----------F 1132
+A + K+ +NL Q + ++ ++ + +EDE ++ K++ D F
Sbjct: 872 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF 931
Query: 1133 DQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVL---LQEEGTRKREYE 1189
D K DQL + Q + + + E K +Y + L +Q+ T +R+ +
Sbjct: 932 DWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
Query: 1190 NELAKASNRIQESKNQCTQVVQERESLLVKI----KVLEQDKARLQRLEDELNRAKSTLE 1245
+ S + NQ +V E E K+ K EQ A ++ E + ++ ++
Sbjct: 992 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1051
Query: 1246 AETRV---KQRLECEKQQIQNDLNQWKTQYSR-----------KEEAIRKIESEREKSER 1291
++ + ++R++ I + +T+Y+ ++++++E E + E
Sbjct: 1052 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1111
Query: 1292 EKNSLRSEIERLQAEIKRIE------ERCRRKLEDSTRETQSQLETERSRYQREIDKLRQ 1345
EK + + LQ + I E+ + + + ++ T++ + + + Q
Sbjct: 1112 EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTI-Q 1170
Query: 1346 RPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVE-E 1404
H + T+ E + L K+V +Q L+ +L +L + + S + +
Sbjct: 1171 LFLAKHGDKMTDEER---------NELEKQVKTLQ-ESYNLLFSESLKQLQESQTSGDVK 1220
Query: 1405 VASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHR 1464
V ++ + G + E S+ +A + LI ++ + LLE Q G+I P
Sbjct: 1221 VEEKLDKVIAGT-----IDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPEL 1275
Query: 1465 NEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMR 1524
+ + A + LID Q+ KA S T+ V +A+ +++I ++
Sbjct: 1276 RKCFDLKDAKSHGLIDEQILCQLKELSKA-KEIISAASPTTIPVLDALAQSMITESMAIK 1334
Query: 1525 LLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSY 1584
+LE +++G +V P L A + L+ L+ + + ++ K+ +DP T +KVS
Sbjct: 1335 VLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSL 1394
Query: 1585 VQLKERCRIEPHTGLLLLSVQKRSMSFQGIR--QPVTVTELVDSGILRPSTVNELESGQI 1642
+ + +R ++ +TG+ LL V+ + ++ + +++ G++ T+ L S Q+
Sbjct: 1395 IDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQL 1454
Query: 1643 SYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFI 1702
L G G+ N + Q++ + EA++ G++ TA +L Q TG I
Sbjct: 1455 ------------LSG-----GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGI 1497
Query: 1703 VDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEK 1762
+ RL V+EA + L+ +L A+R G P +G I ++ +ELI
Sbjct: 1498 IQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITN 1557
Query: 1763 GHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
++L + + P+ S + +D A + G + + IL +
Sbjct: 1558 ELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKN 1603
Score = 95.1 bits (235), Expect = 7e-19
Identities = 191/968 (19%), Positives = 390/968 (40%), Gaps = 144/968 (14%)
Query: 1117 EIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRV 1176
E+ + + R ++ EDR +Q E+++L ES I E+E + L
Sbjct: 745 EVRNIRLRLENCEDRLIRQIRT--------PLERDDLH----ESVFRITEQEKLKKELER 792
Query: 1177 LLQEEGTRKREYEN--ELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLE 1234
L + GT + E A AS+ + +++ V+Q +V + +L+
Sbjct: 793 LKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN------QVYSMSSTYIDKLK 846
Query: 1235 DELNRAKSTLEAETRVK--QRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSERE 1292
K+T AE VK + CE++ + D N + S +++ SE ++ +
Sbjct: 847 TVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS----TLKQWRSEVDEKRQV 902
Query: 1293 KNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHR 1352
++L E+++ +A + D +T + + + ++ + D+L +R H
Sbjct: 903 FHALEDELQKAKA------------ISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHV 950
Query: 1353 ETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPF 1412
+ +D +G+ K +++ Y LD ++ ++ + E QP
Sbjct: 951 Q--------IDNRLRDLEGIGK---SLKYYRDTY---HPLDDWIQQVETTQRKIQENQP- 995
Query: 1413 LRGAGSIAGASASPKEKYSLVEAKRKKLISPE-------STVMLLEAQAAT-GGIIDPHR 1464
+ ++A K S +E K+ K+ + +TV E Q T ++D +
Sbjct: 996 -ENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054
Query: 1465 N---EKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRET 1521
++ + S+ + +F D + Y A + F+G ++ E +K+L + +
Sbjct: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114
Query: 1522 GMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKK 1581
V K++ I + L +D++K P +K+K
Sbjct: 1115 ------------------EHVEKAKELQKWVSNISKTL-------KDAEKAGKPPFSKQK 1149
Query: 1582 VSYVQL---KERCRIEPHTGLLLLSVQKRSMSFQGIRQ-PVTVTELVDS-GILRPSTVNE 1636
+S ++ KE+ T L L+ M+ + + V L +S +L ++ +
Sbjct: 1150 ISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQ 1209
Query: 1637 LESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQ 1696
L+ Q S D E D IAG ++TT + L +++A+ GL+ T + LLE Q
Sbjct: 1210 LQESQTSGDVKVEEKLD-----KVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQ 1264
Query: 1697 AATGFIVDPVSNLRLPVEEAYKRGLVGIEF--KEKLLSAERAVTGYNDPETGNIISLFQA 1754
++ P +++A GL+ + + K LS + + P T I + A
Sbjct: 1265 LMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT---IPVLDA 1321
Query: 1755 MNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTK 1814
+ + +I + I++LE ++TG ++ P +L + A+++ + L + + + K
Sbjct: 1322 LAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCK 1381
Query: 1815 GFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPET 1874
DP T E ++ + + +R E TG+ LLP++ Q + TL+
Sbjct: 1382 DLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRP-----QEGGRITLK----------C 1426
Query: 1875 NKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDA 1934
+ +S+ A +GLID ET L + ++G L++ +G + +++A
Sbjct: 1427 GRNISILRAAHEGLIDRETMFRLLSAQL------LSGG-------LINSNSGQRMTVEEA 1473
Query: 1935 IDKGLVDRKFFD-----QYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH- 1988
+ +G++DR Q ++G + + A +++ V S + + +
Sbjct: 1474 VREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYV 1533
Query: 1989 -----ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIV 2043
S T SS++ I + L IAA++ E+ + I + + GI+
Sbjct: 1534 GLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGII 1593
Query: 2044 DSITGQRL 2051
D+ T L
Sbjct: 1594 DNNTASIL 1601
Score = 92.4 bits (228), Expect = 4e-18
Identities = 97/390 (24%), Positives = 164/390 (42%), Gaps = 54/390 (13%)
Query: 1800 EELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQ- 1858
E+LSE L D T+E L+ + + +++ L E KQ+Q SQ
Sbjct: 1160 EQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN----LLFSESLKQLQESQT 1215
Query: 1859 ------KNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGS 1912
+ L K +D T + +SV +A +GLIDY+T L E + + I+G
Sbjct: 1216 SGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQ-----LMISG- 1269
Query: 1913 DGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSS 1972
L+ + +D++DA GL+D + L Q ++ K + +S
Sbjct: 1270 -------LISPELRKCFDLKDAKSHGLIDEQI----------LCQLKELSKAKEIISAAS 1312
Query: 1973 SMGSGVSDDVFSSSRHESVS------KISTISSVRNLT--------------IRSSSFSD 2012
V D + S ES++ +ST S V T + S+ FS
Sbjct: 1313 PTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSK 1372
Query: 2013 TLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSL 2072
LE + + D EK+S+ + ++R + TG LL + GG I G+ +S+
Sbjct: 1373 VLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISI 1432
Query: 2073 QDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQY 2132
A +G+ID++ RL AQ G ++M+ EAV+E + + L +Q
Sbjct: 1433 LRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492
Query: 2133 LTGGLVDPEVHGRISTEEAIRKGFIDGRAA 2162
TGG++ R++ +EA++ I +A
Sbjct: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSA 1522
Score = 83.6 bits (205), Expect = 2e-15
Identities = 93/458 (20%), Positives = 190/458 (41%), Gaps = 67/458 (14%)
Query: 1713 VEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQ 1772
++E+ G V +E EKL ++ + G D TG ++S+FQA+ + LI+ GIRLLE Q
Sbjct: 1210 LQESQTSGDVKVE--EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQ 1264
Query: 1773 IATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKE 1832
+ G+I P+ + A G +E++ L + S K + + L
Sbjct: 1265 LMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSK-AKEIISAASPTTIPVLDALA 1323
Query: 1833 RCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYE 1892
+ + E + +L + + T +V P T +++++Q+A+++ L+
Sbjct: 1324 QSMITESMAIKVLEIL-----LSTGS----------LVIPATGEQLTLQKAFQQNLVSSA 1368
Query: 1893 TFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGS 1952
F ++ E++ ++ L+D T + + D + + + Q +G
Sbjct: 1369 LFSKVLERQNMCKD-------------LIDPCTSEKVSLIDMVQRSTL------QENTGM 1409
Query: 1953 LSLT---QFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSS 2009
L Q I+LK G S + HE + T+ + + + S
Sbjct: 1410 WLLPVRPQEGGRITLKCGRNIS-----------ILRAAHEGLIDRETMFRLLSAQLLSGG 1458
Query: 2010 FSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQK 2069
+ ++ + +++++ E + G++D T +L Q TGGII ++
Sbjct: 1459 -------------LINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKR 1505
Query: 2070 LSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLE 2129
L++ +AV +I A + AQ+ ++G + + +++++ + E + L
Sbjct: 1506 LTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILN 1565
Query: 2130 FQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQD 2167
+ L PE I + A + G ID A L++
Sbjct: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKN 1603
Score = 80.9 bits (198), Expect = 1e-14
Identities = 65/246 (26%), Positives = 109/246 (44%), Gaps = 32/246 (13%)
Query: 1980 DDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSP-------------IAAIFDT 2026
D + R+E ++ T+ NL S L+ES IA D
Sbjct: 1178 DKMTDEERNELEKQVKTLQESYNLLFSESL--KQLQESQTSGDVKVEEKLDKVIAGTIDQ 1235
Query: 2027 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2086
E +S+ + + RG++D TG RLLE Q G+I P + L+DA S G+ID+ +
Sbjct: 1236 TTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQIL 1295
Query: 2087 TRLKPAQKAFIGFEGVKGKKKMSAA--------EAVKEKWLPYEAGQRFLEFQYLTGGLV 2138
+LK KA K+ +SAA +A+ + + + LE TG LV
Sbjct: 1296 CQLKELSKA---------KEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLV 1346
Query: 2139 DPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDI 2198
P +++ ++A ++ + ++ + + K L P T K+S D + RS +++
Sbjct: 1347 IPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQEN 1406
Query: 2199 TGLRLL 2204
TG+ LL
Sbjct: 1407 TGMWLL 1412
Score = 70.5 bits (171), Expect = 2e-11
Identities = 155/853 (18%), Positives = 335/853 (39%), Gaps = 107/853 (12%)
Query: 902 LYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDK----SEEVQKIAELCANS 957
LY+ K + E D N + ++ K SE+ KR +E+QK +
Sbjct: 864 LYETKLCE---EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEM 920
Query: 958 IKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFL 1017
K Y+ + + E +++ V +Q D R +E + +S YYR
Sbjct: 921 FKTYKERDLDFDWHKEKA------DQLVERWQNVHVQ--IDNRLRDLEGIGKSLKYYR-- 970
Query: 1018 SEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQKYQA---ECS 1070
+ L+D ++E + +++ + NS+ N+ K L ++ Q+ EC
Sbjct: 971 -DTYHPLDDWI---QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQ 1026
Query: 1071 QFKAKLAS------LEELKRQAELDGKSA--------KQNLDKCYGQIKELNEK----IT 1112
++ + ++ L+ + +A +D + + + D + +L + +T
Sbjct: 1027 KYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVT 1086
Query: 1113 RLTYEIE---DEKRRRKSVEDRFDQQKNDYDQLQKARQCEK--ENLGWQKLESEKAIKEK 1167
+T I+ D +R + E +++K ++ ++KA++ +K N+ ++EKA K
Sbjct: 1087 LMTQYIKFAGDSLKRLEEEEKSLEEEKKEH--VEKAKELQKWVSNISKTLKDAEKAGKPP 1144
Query: 1168 EYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDK 1227
+ ++ +E T+K + L + + ++ T +ER L ++K L Q+
Sbjct: 1145 ---FSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTD--EERNELEKQVKTL-QES 1198
Query: 1228 ARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEA--------- 1278
L E +S + +V+++L+ + I ++Q + +A
Sbjct: 1199 YNLLFSESLKQLQESQTSGDVKVEEKLD---KVIAGTIDQTTGEVLSVFQAVLRGLIDYD 1255
Query: 1279 --IRKIESEREKSEREKNSLRSEIERLQAEIKR-IEERCRRKLEDSTRETQSQLETERSR 1335
IR +E++ S LR + A+ I+E+ +L++ ++ + +
Sbjct: 1256 TGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEI-ISAASPT 1314
Query: 1336 YQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKL 1395
+D L Q + E + T LV +++T + ++ L+ K+
Sbjct: 1315 TIPVLDALAQSMITESMAIKV-LEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373
Query: 1396 LKGKKSVEEVASEI------------QPFLRGAGSIAGASASPKE----------KYSLV 1433
L+ + +++ + L+ + P+E S++
Sbjct: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISIL 1433
Query: 1434 EAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKA 1493
A + LI E+ LL AQ +GG+I+ + +++TV+ A+ +ID D I +
Sbjct: 1434 RAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQ 1493
Query: 1494 ITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARG 1553
G K ++V EA++ +LI + + +LEAQ G++ P + P +L +
Sbjct: 1494 TGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQE 1553
Query: 1554 LIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL--LSVQKRSMSF 1611
LI +L + + R P + + + K+ I+ +T +L +++ +
Sbjct: 1554 LITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPDL 1613
Query: 1612 QGIRQPVTVTELVDSGILRPSTVNELESGQISYD-------EVGERIKDFLQGSSCIAGI 1664
+ + +PSTV++ + +D + E K I
Sbjct: 1614 GDLEACKNARRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQTSEETKKLFLSYLMINSY 1673
Query: 1665 YNETTKQKLGIYE 1677
+ T Q+L +Y+
Sbjct: 1674 MDANTGQRLLLYD 1686
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 577 bits (1488), Expect = e-164
Identities = 350/1260 (27%), Positives = 651/1260 (51%), Gaps = 131/1260 (10%)
Query: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
+E + L W+ + + ++D WG DL SVE H+ +H+ +H +I ++ L + K
Sbjct: 630 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 689
Query: 241 DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
+ +A +++LE +Y LL S + HL L N + + E++W+N+ EE
Sbjct: 690 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 749
Query: 292 EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
EE+ YDWS++NTNIA+K++ + M +L+ KE+ + +++ ++QL+L HPA IEAY
Sbjct: 750 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 809
Query: 352 DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
+QTQWSWILQ+ +C++ H+KEN AYF+FF +A+ YL+ L+D+I++KY CD++ +
Sbjct: 810 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 869
Query: 412 QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
L + ++E +E+E++L+YK + NL+ K+K I+QLKPRN D I ++A+CDY+Q
Sbjct: 870 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 929
Query: 472 DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
+ ++K DEC+L +N+ R+KW V P G + +VPSV +PPPN AVDL+ +IEQ Y+
Sbjct: 930 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 989
Query: 532 AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
+L LW++ +INMKS+VSWHY + +I++IRA +A +KTM ++ + +++L+ +++F+
Sbjct: 990 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1049
Query: 592 RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
+SQ S++F D +++ + +++YQ L+
Sbjct: 1050 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1081
Query: 652 NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
K E + + + E++ IR ++E+CE R+ + ++ H +I E +
Sbjct: 1082 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1140
Query: 712 VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
++ + + + + + N+ ++ + S L++E+ + Q + + ++ Y++ L
Sbjct: 1141 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1200
Query: 768 CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
TV +L+ E ++K+YE +L EEE V D + +E LK+ +++++ K+ +
Sbjct: 1201 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1260
Query: 828 MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
++ ELQKA+ I + + Y DLD EK QL +RWQ + QID RL DLE K
Sbjct: 1261 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1320
Query: 888 LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
L+ YRD Y W+ + Q ++ + +S T+ LN+QK L SEI K+ K +E
Sbjct: 1321 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1380
Query: 948 QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
QK AE + ++KDYELQ +Y + +++ P+KR +QS + +I+QE D+ RY L+
Sbjct: 1381 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1440
Query: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLE-------------EELRLARDANSENC 1052
T Y +F + LK L E+ L+ K E +E + L+ A A
Sbjct: 1441 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1500
Query: 1053 NKNKFLDQNLQKYQAECSQ-------FKAKLAS--LEELKRQAELDGKSAKQNLDKCYGQ 1103
+K K + + + + S+ F AK +E + + E K+ +++ + + +
Sbjct: 1501 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1560
Query: 1104 -IKELNEKITRLTYEIEDE---------KRRRKSVEDRFDQQKNDYDQLQKARQCEKENL 1153
+K+L E T ++E++ K + + + D Q +N Q+A +
Sbjct: 1561 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1620
Query: 1154 GWQKLESEKAIKEKEYE---------IERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
+K +S++ +K+ + ++ L+E G + + + L + ++ E+K
Sbjct: 1621 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKI 1678
Query: 1205 QCTQV------------------VQERESLLVKIKVLEQDKARLQRLEDEL-NRAKSTLE 1245
+C Q+ ++E + +K LE+ K +++ L D L N K +
Sbjct: 1679 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1738
Query: 1246 AETRVKQRLE---------------CEKQQIQNDL------NQWKTQYSRKEEAIRKIES 1284
A T+ KQ +E E+ ++ +L Q T + +K+++
Sbjct: 1739 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1798
Query: 1285 EREKSEREKNSLRSEIERLQAEIKR----IEERCRRKLEDSTRETQSQLETERSRYQREI 1340
+ EK + ++ + Q +++ + + KL+ + +E + ET + ++++
Sbjct: 1799 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1858
Score = 63.9 bits (154), Expect = 2e-09
Identities = 124/642 (19%), Positives = 249/642 (38%), Gaps = 89/642 (13%)
Query: 836 QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
Q TS Q +DLD + RW+ ++K++ R L++ + ++D
Sbjct: 3294 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3344
Query: 896 QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
++ W+ D + + + + V + EQK L + ++ E +++ E A
Sbjct: 3345 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3403
Query: 956 NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
+ + + QL+ S E LLN R V+ Q+ + E L
Sbjct: 3404 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3456
Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECS 1070
++ + + L + E + T+ LEE++ + + N NK L Q + Q
Sbjct: 3457 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ---- 3509
Query: 1071 QFKAKLASLEELKRQAELDGKSAKQNLDKC-YGQIKELNEKITRLTYE-IEDEKRRRKSV 1128
SL+ L + + D +K + + Y +I+E + + L + + + K +
Sbjct: 3510 -------SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDE 3562
Query: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREY 1188
+ + +D+L K + G K +SE LRVL ++ RK+
Sbjct: 3563 VELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE------------LRVLQEDILLRKQNV 3610
Query: 1189 ENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET 1248
+ L ++++ ++Q++ LE KAR + + TLE
Sbjct: 3611 DQALLNGLELLKQTTGDEVLIIQDK---------LEAIKARYKDITKLSTDVAKTLEQAL 3661
Query: 1249 RVKQRLECEKQQ-------IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS---LRS 1298
++ +RL ++ ++ +L ++TQ + EEA + +E + KN+ L S
Sbjct: 3662 QLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDS 3721
Query: 1299 EIERLQAEIKRIEERCRRKLEDSTRETQSQ---LETERSRYQREIDKLRQRPYGSHRETQ 1355
E A ++ + R R LE E + + ++ EID R +
Sbjct: 3722 LNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3781
Query: 1356 TECEWTVDTSKLVFD----GLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQP 1411
E W +T K + L + T+ QL + KT ++L+ K ++++
Sbjct: 3782 AELSWITETEKKLMSLGDIRLEQDQTSAQLQ----VQKTFTMEILRHKDIIDDLVK---- 3833
Query: 1412 FLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQ 1453
+G + S +EK S+ + K K++ T+ + ++
Sbjct: 3834 ----SGHKIMTACSEEEKQSM-KKKLDKVLKNYDTICQINSE 3870
Score = 53.5 bits (127), Expect = 2e-06
Identities = 145/819 (17%), Positives = 331/819 (40%), Gaps = 130/819 (15%)
Query: 528 QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
QY + + A+++ + I L S D+E ++ I +LK + E Y + I L++
Sbjct: 4214 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4272
Query: 588 QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
Q + + +E + DK +Q + + + +L
Sbjct: 4273 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4304
Query: 648 DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
++I NR++ + + + L ++ + H EG ++ + P+ G I
Sbjct: 4305 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4356
Query: 703 TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
+++ + +QND Q+ E +N+ + L E+ LQN++ L Q+ +N+
Sbjct: 4357 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4416
Query: 760 TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
T+ Q Q + L+ + E E + L E + K +
Sbjct: 4417 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4463
Query: 815 --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
K LN+ + A T K+ +QK QQ+ ++ + + + L +
Sbjct: 4464 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4517
Query: 866 RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
+W+ ++ +++ R LE+ + + ++ Q F WL A++ ++ S +TV+
Sbjct: 4518 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4576
Query: 926 FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
++E K +E++ R++ E+ K L+ S + + N+ I +
Sbjct: 4577 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4624
Query: 986 QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
QS ++Q + + R+ ++ S++++ LE+ + + L+ EL +A
Sbjct: 4625 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4678
Query: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
D + ++ A+ +F+ L + + G+S K+ +K
Sbjct: 4679 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4726
Query: 1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIK 1165
L++ ++ L + + + +++ ++ Q A Q + L ++E + A
Sbjct: 4727 -LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWL--YRVEPQLAED 4783
Query: 1166 EKEY-EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLE 1224
+ + +I+ + L+ + ++ EL K ++ +Q K ++++ +KV
Sbjct: 4784 QPVHGDIDLVMNLIDNH----KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQM 4839
Query: 1225 QDKARLQRLEDELNRAKST-LEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIE 1283
Q+ + L+ +K T LEA R + E + + L +W + E+ +R
Sbjct: 4840 QELSTRWETVCALSISKQTRLEAALRQAE----EFHSVVHALLEW---LAEAEQTLR--- 4889
Query: 1284 SEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDST 1322
++++LR+ I++ + +K++EE+ R +L +T
Sbjct: 4890 -FHGVLPDDEDALRTLIDQHKEFMKKLEEK-RAELNKAT 4926
Score = 52.0 bits (123), Expect = 7e-06
Identities = 132/763 (17%), Positives = 306/763 (40%), Gaps = 86/763 (11%)
Query: 713 QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
QN QA+ L LK ++ +Q+++ + + ++I ++ +L
Sbjct: 3608 QNVDQALLNGLELLKQTTG-----DEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3662
Query: 773 LLQAILQTEDMLKVY----EARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
L + + T + L + E L ET L ++ + K++K + K+LL ++
Sbjct: 3663 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3722
Query: 829 KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888
++ S + P + + V + +R++ + I ++ +++ I +
Sbjct: 3723 N-------EVSSALLELVPWRARE--GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3773
Query: 889 RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
+ + A W+ + +++ SL ++ T + L QK EI +D +++
Sbjct: 3774 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ-LQVQKTFTMEILRHKDIIDDLV 3832
Query: 949 KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
K + + E Q S L+ +L I S + L+ A + ++ E
Sbjct: 3833 KSGHKIMTACSEEEKQ--SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3890
Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQK 1064
+ ++ L L+ + +EE R R+ +E+ NK Q L+
Sbjct: 3891 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3950
Query: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED--EK 1122
E + K + + L Q + D K LD+ Q + ++KI ++ +E E+
Sbjct: 3951 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4010
Query: 1123 RRR--------KSVEDRFDQQKN---DYDQLQKARQCEKE--------NLGWQKLESEKA 1163
R+ + ++++ + KN D ++LQ + K+ + G K S KA
Sbjct: 4011 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4070
Query: 1164 IKEKEYEI----ERLRVLLQEEGTRKREYENELAKA----SNRIQESKNQCTQVVQERES 1215
+++K ++ E + L++E + + ELA+ + + +++ E
Sbjct: 4071 VQDKLDQMVFIWENIHTLVEEREAKLLDV-MELAEKFWCDHMSLIVTIKDTQDFIRDLED 4129
Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-----ECEKQQIQNDLNQ--- 1267
+ V++Q + + + +E++ + L+ + L E +K ++ +++
Sbjct: 4130 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4189
Query: 1268 -WKTQYSRKEEAIRKIESEREKSEREKNSLR-------------SEIERLQAEIKRIEER 1313
W + ++ I K+E + + + ++ L+ + + + +++ ++++
Sbjct: 4190 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4249
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
+ + Q Q+E ER +Q E+ L++ S + T + + KL++D L
Sbjct: 4250 IEELKQFKSEAYQQQIEMERLNHQAEL-LLKKVTEESDKHTVQD---PLMELKLIWDSLE 4305
Query: 1374 KKVTAMQ-LYECQLID----KTTLDKLLKGKKSVEEVASEIQP 1411
+++ Q E L+ + LD+LL E + SE +P
Sbjct: 4306 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4348
Score = 50.1 bits (118), Expect = 3e-05
Identities = 99/551 (17%), Positives = 224/551 (40%), Gaps = 68/551 (12%)
Query: 773 LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832
L Q + + L+ LT+ +TV L + + + + L++ ++L T + ++
Sbjct: 2552 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQV 2611
Query: 833 QKAQQIHSQTSQQY-------------PLYDLDL-GKFGEKVTQLTDRWQRIDKQIDFRL 878
Q Q + QY P D L G E++ +T +W + Q+ R
Sbjct: 2612 QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRC 2671
Query: 879 WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
+++ I + Y+ ++ L D + S ++ + + + L + + EI
Sbjct: 2672 DWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST-HPDAMNQQLETAQKMKQEIQ 2730
Query: 939 GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
++ + + Q + E + +K+ L+ A + LE +L S +++ A+
Sbjct: 2731 QEKKQIKVAQALCEDLSALVKEEYLK-AELSRQLEGILK-----------SFKDVEQKAE 2778
Query: 999 VHARYIELLTRSGDYYRFLSEMLKSLEDLKLK--------NTKIEVLEEELRLARDANSE 1050
H ++++ S ++ +S ++ D K + + K++VLE ++ +D +
Sbjct: 2779 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2838
Query: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEK 1110
++ ++ + AE K E+ Q +L+ + K N D Q+KE K
Sbjct: 2839 LTAQSHMYEKTI----AEGENLLLKTQGSEKAALQLQLN--TIKTNWDTFNKQVKERENK 2892
Query: 1111 ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAI-KEKEY 1169
+ +E + ++ VE + + L++ + C G + K++ KE +
Sbjct: 2893 LKE---SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2949
Query: 1170 EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIK-VLEQDKA 1228
+ +L N A + + E + V E +SL+ K+ V EQ +
Sbjct: 2950 HFGMVELL------------NNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHS 2995
Query: 1229 RLQRLEDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIR 1280
+ LE+ + K E K++L+C K+Q+ Q N++ T ++++++
Sbjct: 2996 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3055
Query: 1281 KIESEREKSER 1291
++ + + ++R
Sbjct: 3056 ALKHQVDLAKR 3066
Score = 48.5 bits (114), Expect = 7e-05
Identities = 140/703 (19%), Positives = 270/703 (38%), Gaps = 92/703 (13%)
Query: 674 KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
KI + +E E + P + I +I+E K+V D + + + LK +M
Sbjct: 3996 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4055
Query: 730 LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
+A G++K +Q+++ + ENI+ + + L C +L+
Sbjct: 4056 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4115
Query: 776 AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
I T+D ++ E + V + E R + ++ +L++ +L +
Sbjct: 4116 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4166
Query: 836 QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
+ I + P+ + + +L W ++K R+ LE+ ++ Y+D
Sbjct: 4167 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4219
Query: 896 QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
QA W+ A + S+ + D TV + + E K SE ++ + E + AEL
Sbjct: 4220 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4278
Query: 955 --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
++++D ++L LE + I R G +L HA EL
Sbjct: 4279 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4332
Query: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
L LSE D ++++ K VL+ ++ LA + E NK N ++ +
Sbjct: 4333 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4391
Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
+ E S + KL L + + + KQ LD Q K + +I L + D
Sbjct: 4392 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4448
Query: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
+R V F+ ++ Y L QK +Q +
Sbjct: 4449 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4508
Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQV-----VQERES 1215
++ I + + E + L E T+ E N + N +Q+ N TQ V R S
Sbjct: 4509 DQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPS 4568
Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ---IQNDL----NQW 1268
L++ + + D+ ++ E +R + +T + +KQ I+N L ++W
Sbjct: 4569 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4628
Query: 1269 KTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1311
+ R E R ++ R+++++ + +E L+ K ++
Sbjct: 4629 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4671
Score = 43.1 bits (100), Expect = 0.003
Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)
Query: 198 QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
Q AE V +DL V I++H+ +G + +K RE K
Sbjct: 4779 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4836
Query: 246 SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
+ +L +E + S + L RQ + + W+ + E+ +L D
Sbjct: 4837 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4896
Query: 298 WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
D + + + F M +LE K ELNK D ++ HP S I+ ++ ++
Sbjct: 4897 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4953
Query: 357 QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
++ +L K L +A + + EA L LQ + DK + Q +E
Sbjct: 4954 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 5010
Query: 417 QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
++K L E + +E + Q V+K K + + +P +S+ P++ + K+
Sbjct: 5011 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5070
Query: 474 KIVHKGDECILKDNNER-----SKW 493
+ G + ++ N R SKW
Sbjct: 5071 SLYPSGSQTQIETKNPRVNLLVSKW 5095
Score = 42.4 bits (98), Expect = 0.005
Identities = 102/546 (18%), Positives = 223/546 (40%), Gaps = 84/546 (15%)
Query: 814 IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
+K + KS A +K + K Q++ + ++ + + ++ + +T++ +WQ ++
Sbjct: 2494 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2553
Query: 872 KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
+ R LE+ L ++ +WL + + L + D N LN Q+
Sbjct: 2554 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2608
Query: 932 NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
++VQ + + A YE T+ + +L+ P + ++ G+
Sbjct: 2609 -------------QQVQILLQEFATRKPQYE----QLTAAGQGILSRPGEDPSLR---GI 2648
Query: 992 ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSEN 1051
+ ++ A V ++ L + LS+ ++ +K+T+ + L LR D S+
Sbjct: 2649 VKEQLAAVTQKWDSLTGQ-------LSDRCDWIDQAIVKSTQYQSL---LRSLSDKLSDL 2698
Query: 1052 CNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKI 1111
NK L +L +L + +++K++ + + K K C + E+
Sbjct: 2699 DNK---LSSSL-AVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2754
Query: 1112 TR--LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-------RQCEKENLGWQKLESEK 1162
+ L+ ++E + K VE + +N LQ A +Q ++ W L+++K
Sbjct: 2755 LKAELSRQLEGILKSFKDVEQK---AENHVQHLQSACASSHQFQQMSRDFQAW--LDTKK 2809
Query: 1163 AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKV 1222
+ K + I +L+ +++ L S+ +++ + E E+LL+K +
Sbjct: 2810 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT-------IAEGENLLLKTQG 2862
Query: 1223 LEQDKARLQ-------------RLEDELNRAKSTLEAETRVKQRLECEKQQI---QNDLN 1266
E+ +LQ ++++ N+ K +LE + K+++E I QN+L
Sbjct: 2863 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2922
Query: 1267 QWK--TQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE 1324
+ K + E +I K++S ++E + +E L + C E T E
Sbjct: 2923 EIKFCLDPAEGENSIAKLKS----LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDE 2978
Query: 1325 TQSQLE 1330
+S ++
Sbjct: 2979 NKSLIQ 2984
Score = 41.2 bits (95), Expect = 0.012
Identities = 58/293 (19%), Positives = 126/293 (43%), Gaps = 40/293 (13%)
Query: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
KSLED K K + E++ ++ CN A + KA +A+++
Sbjct: 2352 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL----------ISAVTTPAKA-IAAVKS 2400
Query: 1082 LKRQAELDGKSAKQNLDKCYGQ--IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139
A L+G+ N ++ + + + + +T +++ ED K D+ +
Sbjct: 2401 --GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK---DKIAELNTKL 2455
Query: 1140 DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI 1199
+LQKA++ + W + ++ A K ++ ++ + + + +E EL + N++
Sbjct: 2456 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2515
Query: 1200 QESKNQCTQVVQER---------ESLLVKIKVLEQDKARL-----QRLEDELNRAKSTLE 1245
QE K++ T++++E + +L +I Q+ +L Q+LE+ N
Sbjct: 2516 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2575
Query: 1246 AETRVKQRLECEKQ-------QIQNDLNQWKTQYSRKEEAIRKIESEREKSER 1291
E ++KQ L EK+ + D N TQ + + +++ + + + E+
Sbjct: 2576 VEAQLKQWL-VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2627
Score = 35.8 bits (81), Expect = 0.49
Identities = 16/28 (57%), Positives = 22/28 (78%)
Query: 2223 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2250
A ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 5439 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5466
Score = 35.4 bits (80), Expect = 0.64
Identities = 16/27 (59%), Positives = 20/27 (74%)
Query: 2226 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2252
SR GSR+GS++GSR+ SR GS FD
Sbjct: 5446 SRPGSRAGSKAGSRASSRRGSDASDFD 5472
Score = 33.1 bits (74), Expect = 3.2
Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)
Query: 2199 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2242
+GL AA V ++ S S PGSR+GS++GSR+ SR GS
Sbjct: 5424 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5466
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 577 bits (1488), Expect = e-164
Identities = 350/1260 (27%), Positives = 651/1260 (51%), Gaps = 131/1260 (10%)
Query: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
+E + L W+ + + ++D WG DL SVE H+ +H+ +H +I ++ L + K
Sbjct: 641 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700
Query: 241 DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
+ +A +++LE +Y LL S + HL L N + + E++W+N+ EE
Sbjct: 701 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760
Query: 292 EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
EE+ YDWS++NTNIA+K++ + M +L+ KE+ + +++ ++QL+L HPA IEAY
Sbjct: 761 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820
Query: 352 DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
+QTQWSWILQ+ +C++ H+KEN AYF+FF +A+ YL+ L+D+I++KY CD++ +
Sbjct: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880
Query: 412 QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
L + ++E +E+E++L+YK + NL+ K+K I+QLKPRN D I ++A+CDY+Q
Sbjct: 881 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940
Query: 472 DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
+ ++K DEC+L +N+ R+KW V P G + +VPSV +PPPN AVDL+ +IEQ Y+
Sbjct: 941 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000
Query: 532 AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
+L LW++ +INMKS+VSWHY + +I++IRA +A +KTM ++ + +++L+ +++F+
Sbjct: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060
Query: 592 RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
+SQ S++F D +++ + +++YQ L+
Sbjct: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1092
Query: 652 NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
K E + + + E++ IR ++E+CE R+ + ++ H +I E +
Sbjct: 1093 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1151
Query: 712 VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
++ + + + + + N+ ++ + S L++E+ + Q + + ++ Y++ L
Sbjct: 1152 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1211
Query: 768 CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
TV +L+ E ++K+YE +L EEE V D + +E LK+ +++++ K+ +
Sbjct: 1212 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1271
Query: 828 MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
++ ELQKA+ I + + Y DLD EK QL +RWQ + QID RL DLE K
Sbjct: 1272 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1331
Query: 888 LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
L+ YRD Y W+ + Q ++ + +S T+ LN+QK L SEI K+ K +E
Sbjct: 1332 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1391
Query: 948 QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
QK AE + ++KDYELQ +Y + +++ P+KR +QS + +I+QE D+ RY L+
Sbjct: 1392 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1451
Query: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLE-------------EELRLARDANSENC 1052
T Y +F + LK L E+ L+ K E +E + L+ A A
Sbjct: 1452 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1511
Query: 1053 NKNKFLDQNLQKYQAECSQ-------FKAKLAS--LEELKRQAELDGKSAKQNLDKCYGQ 1103
+K K + + + + S+ F AK +E + + E K+ +++ + + +
Sbjct: 1512 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1571
Query: 1104 -IKELNEKITRLTYEIEDE---------KRRRKSVEDRFDQQKNDYDQLQKARQCEKENL 1153
+K+L E T ++E++ K + + + D Q +N Q+A +
Sbjct: 1572 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1631
Query: 1154 GWQKLESEKAIKEKEYE---------IERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
+K +S++ +K+ + ++ L+E G + + + L + ++ E+K
Sbjct: 1632 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKI 1689
Query: 1205 QCTQV------------------VQERESLLVKIKVLEQDKARLQRLEDEL-NRAKSTLE 1245
+C Q+ ++E + +K LE+ K +++ L D L N K +
Sbjct: 1690 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1749
Query: 1246 AETRVKQRLE---------------CEKQQIQNDL------NQWKTQYSRKEEAIRKIES 1284
A T+ KQ +E E+ ++ +L Q T + +K+++
Sbjct: 1750 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1809
Query: 1285 EREKSEREKNSLRSEIERLQAEIKR----IEERCRRKLEDSTRETQSQLETERSRYQREI 1340
+ EK + ++ + Q +++ + + KL+ + +E + ET + ++++
Sbjct: 1810 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1869
Score = 63.9 bits (154), Expect = 2e-09
Identities = 124/642 (19%), Positives = 249/642 (38%), Gaps = 89/642 (13%)
Query: 836 QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
Q TS Q +DLD + RW+ ++K++ R L++ + ++D
Sbjct: 3305 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3355
Query: 896 QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
++ W+ D + + + + V + EQK L + ++ E +++ E A
Sbjct: 3356 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3414
Query: 956 NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
+ + + QL+ S E LLN R V+ Q+ + E L
Sbjct: 3415 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3467
Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECS 1070
++ + + L + E + T+ LEE++ + + N NK L Q + Q
Sbjct: 3468 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ---- 3520
Query: 1071 QFKAKLASLEELKRQAELDGKSAKQNLDKC-YGQIKELNEKITRLTYE-IEDEKRRRKSV 1128
SL+ L + + D +K + + Y +I+E + + L + + + K +
Sbjct: 3521 -------SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDE 3573
Query: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREY 1188
+ + +D+L K + G K +SE LRVL ++ RK+
Sbjct: 3574 VELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE------------LRVLQEDILLRKQNV 3621
Query: 1189 ENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET 1248
+ L ++++ ++Q++ LE KAR + + TLE
Sbjct: 3622 DQALLNGLELLKQTTGDEVLIIQDK---------LEAIKARYKDITKLSTDVAKTLEQAL 3672
Query: 1249 RVKQRLECEKQQ-------IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS---LRS 1298
++ +RL ++ ++ +L ++TQ + EEA + +E + KN+ L S
Sbjct: 3673 QLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDS 3732
Query: 1299 EIERLQAEIKRIEERCRRKLEDSTRETQSQ---LETERSRYQREIDKLRQRPYGSHRETQ 1355
E A ++ + R R LE E + + ++ EID R +
Sbjct: 3733 LNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3792
Query: 1356 TECEWTVDTSKLVFD----GLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQP 1411
E W +T K + L + T+ QL + KT ++L+ K ++++
Sbjct: 3793 AELSWITETEKKLMSLGDIRLEQDQTSAQLQ----VQKTFTMEILRHKDIIDDLVK---- 3844
Query: 1412 FLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQ 1453
+G + S +EK S+ + K K++ T+ + ++
Sbjct: 3845 ----SGHKIMTACSEEEKQSM-KKKLDKVLKNYDTICQINSE 3881
Score = 53.5 bits (127), Expect = 2e-06
Identities = 145/819 (17%), Positives = 331/819 (40%), Gaps = 130/819 (15%)
Query: 528 QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
QY + + A+++ + I L S D+E ++ I +LK + E Y + I L++
Sbjct: 4225 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4283
Query: 588 QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
Q + + +E + DK +Q + + + +L
Sbjct: 4284 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4315
Query: 648 DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
++I NR++ + + + L ++ + H EG ++ + P+ G I
Sbjct: 4316 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4367
Query: 703 TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
+++ + +QND Q+ E +N+ + L E+ LQN++ L Q+ +N+
Sbjct: 4368 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4427
Query: 760 TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
T+ Q Q + L+ + E E + L E + K +
Sbjct: 4428 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4474
Query: 815 --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
K LN+ + A T K+ +QK QQ+ ++ + + + L +
Sbjct: 4475 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4528
Query: 866 RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
+W+ ++ +++ R LE+ + + ++ Q F WL A++ ++ S +TV+
Sbjct: 4529 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4587
Query: 926 FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
++E K +E++ R++ E+ K L+ S + + N+ I +
Sbjct: 4588 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4635
Query: 986 QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
QS ++Q + + R+ ++ S++++ LE+ + + L+ EL +A
Sbjct: 4636 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4689
Query: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
D + ++ A+ +F+ L + + G+S K+ +K
Sbjct: 4690 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4737
Query: 1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIK 1165
L++ ++ L + + + +++ ++ Q A Q + L ++E + A
Sbjct: 4738 -LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWL--YRVEPQLAED 4794
Query: 1166 EKEY-EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLE 1224
+ + +I+ + L+ + ++ EL K ++ +Q K ++++ +KV
Sbjct: 4795 QPVHGDIDLVMNLIDNH----KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQM 4850
Query: 1225 QDKARLQRLEDELNRAKST-LEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIE 1283
Q+ + L+ +K T LEA R + E + + L +W + E+ +R
Sbjct: 4851 QELSTRWETVCALSISKQTRLEAALRQAE----EFHSVVHALLEW---LAEAEQTLR--- 4900
Query: 1284 SEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDST 1322
++++LR+ I++ + +K++EE+ R +L +T
Sbjct: 4901 -FHGVLPDDEDALRTLIDQHKEFMKKLEEK-RAELNKAT 4937
Score = 52.0 bits (123), Expect = 7e-06
Identities = 132/763 (17%), Positives = 306/763 (40%), Gaps = 86/763 (11%)
Query: 713 QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
QN QA+ L LK ++ +Q+++ + + ++I ++ +L
Sbjct: 3619 QNVDQALLNGLELLKQTTG-----DEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3673
Query: 773 LLQAILQTEDMLKVY----EARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
L + + T + L + E L ET L ++ + K++K + K+LL ++
Sbjct: 3674 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3733
Query: 829 KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888
++ S + P + + V + +R++ + I ++ +++ I +
Sbjct: 3734 N-------EVSSALLELVPWRARE--GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3784
Query: 889 RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
+ + A W+ + +++ SL ++ T + L QK EI +D +++
Sbjct: 3785 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ-LQVQKTFTMEILRHKDIIDDLV 3843
Query: 949 KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
K + + E Q S L+ +L I S + L+ A + ++ E
Sbjct: 3844 KSGHKIMTACSEEEKQ--SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3901
Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQK 1064
+ ++ L L+ + +EE R R+ +E+ NK Q L+
Sbjct: 3902 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3961
Query: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED--EK 1122
E + K + + L Q + D K LD+ Q + ++KI ++ +E E+
Sbjct: 3962 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4021
Query: 1123 RRR--------KSVEDRFDQQKN---DYDQLQKARQCEKE--------NLGWQKLESEKA 1163
R+ + ++++ + KN D ++LQ + K+ + G K S KA
Sbjct: 4022 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4081
Query: 1164 IKEKEYEI----ERLRVLLQEEGTRKREYENELAKA----SNRIQESKNQCTQVVQERES 1215
+++K ++ E + L++E + + ELA+ + + +++ E
Sbjct: 4082 VQDKLDQMVFIWENIHTLVEEREAKLLDV-MELAEKFWCDHMSLIVTIKDTQDFIRDLED 4140
Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-----ECEKQQIQNDLNQ--- 1267
+ V++Q + + + +E++ + L+ + L E +K ++ +++
Sbjct: 4141 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4200
Query: 1268 -WKTQYSRKEEAIRKIESEREKSEREKNSLR-------------SEIERLQAEIKRIEER 1313
W + ++ I K+E + + + ++ L+ + + + +++ ++++
Sbjct: 4201 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4260
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
+ + Q Q+E ER +Q E+ L++ S + T + + KL++D L
Sbjct: 4261 IEELKQFKSEAYQQQIEMERLNHQAEL-LLKKVTEESDKHTVQD---PLMELKLIWDSLE 4316
Query: 1374 KKVTAMQ-LYECQLID----KTTLDKLLKGKKSVEEVASEIQP 1411
+++ Q E L+ + LD+LL E + SE +P
Sbjct: 4317 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4359
Score = 50.1 bits (118), Expect = 3e-05
Identities = 99/551 (17%), Positives = 224/551 (40%), Gaps = 68/551 (12%)
Query: 773 LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832
L Q + + L+ LT+ +TV L + + + + L++ ++L T + ++
Sbjct: 2563 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQV 2622
Query: 833 QKAQQIHSQTSQQY-------------PLYDLDL-GKFGEKVTQLTDRWQRIDKQIDFRL 878
Q Q + QY P D L G E++ +T +W + Q+ R
Sbjct: 2623 QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRC 2682
Query: 879 WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
+++ I + Y+ ++ L D + S ++ + + + L + + EI
Sbjct: 2683 DWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST-HPDAMNQQLETAQKMKQEIQ 2741
Query: 939 GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
++ + + Q + E + +K+ L+ A + LE +L S +++ A+
Sbjct: 2742 QEKKQIKVAQALCEDLSALVKEEYLK-AELSRQLEGILK-----------SFKDVEQKAE 2789
Query: 999 VHARYIELLTRSGDYYRFLSEMLKSLEDLKLK--------NTKIEVLEEELRLARDANSE 1050
H ++++ S ++ +S ++ D K + + K++VLE ++ +D +
Sbjct: 2790 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2849
Query: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEK 1110
++ ++ + AE K E+ Q +L+ + K N D Q+KE K
Sbjct: 2850 LTAQSHMYEKTI----AEGENLLLKTQGSEKAALQLQLN--TIKTNWDTFNKQVKERENK 2903
Query: 1111 ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAI-KEKEY 1169
+ +E + ++ VE + + L++ + C G + K++ KE +
Sbjct: 2904 LKE---SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2960
Query: 1170 EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIK-VLEQDKA 1228
+ +L N A + + E + V E +SL+ K+ V EQ +
Sbjct: 2961 HFGMVELL------------NNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHS 3006
Query: 1229 RLQRLEDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIR 1280
+ LE+ + K E K++L+C K+Q+ Q N++ T ++++++
Sbjct: 3007 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3066
Query: 1281 KIESEREKSER 1291
++ + + ++R
Sbjct: 3067 ALKHQVDLAKR 3077
Score = 48.5 bits (114), Expect = 7e-05
Identities = 140/703 (19%), Positives = 270/703 (38%), Gaps = 92/703 (13%)
Query: 674 KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
KI + +E E + P + I +I+E K+V D + + + LK +M
Sbjct: 4007 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066
Query: 730 LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
+A G++K +Q+++ + ENI+ + + L C +L+
Sbjct: 4067 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4126
Query: 776 AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
I T+D ++ E + V + E R + ++ +L++ +L +
Sbjct: 4127 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4177
Query: 836 QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
+ I + P+ + + +L W ++K R+ LE+ ++ Y+D
Sbjct: 4178 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4230
Query: 896 QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
QA W+ A + S+ + D TV + + E K SE ++ + E + AEL
Sbjct: 4231 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4289
Query: 955 --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
++++D ++L LE + I R G +L HA EL
Sbjct: 4290 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4343
Query: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
L LSE D ++++ K VL+ ++ LA + E NK N ++ +
Sbjct: 4344 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4402
Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
+ E S + KL L + + + KQ LD Q K + +I L + D
Sbjct: 4403 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4459
Query: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
+R V F+ ++ Y L QK +Q +
Sbjct: 4460 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4519
Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQV-----VQERES 1215
++ I + + E + L E T+ E N + N +Q+ N TQ V R S
Sbjct: 4520 DQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPS 4579
Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ---IQNDL----NQW 1268
L++ + + D+ ++ E +R + +T + +KQ I+N L ++W
Sbjct: 4580 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639
Query: 1269 KTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1311
+ R E R ++ R+++++ + +E L+ K ++
Sbjct: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4682
Score = 43.1 bits (100), Expect = 0.003
Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)
Query: 198 QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
Q AE V +DL V I++H+ +G + +K RE K
Sbjct: 4790 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847
Query: 246 SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
+ +L +E + S + L RQ + + W+ + E+ +L D
Sbjct: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907
Query: 298 WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
D + + + F M +LE K ELNK D ++ HP S I+ ++ ++
Sbjct: 4908 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4964
Query: 357 QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
++ +L K L +A + + EA L LQ + DK + Q +E
Sbjct: 4965 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 5021
Query: 417 QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
++K L E + +E + Q V+K K + + +P +S+ P++ + K+
Sbjct: 5022 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5081
Query: 474 KIVHKGDECILKDNNER-----SKW 493
+ G + ++ N R SKW
Sbjct: 5082 SLYPSGSQTQIETKNPRVNLLVSKW 5106
Score = 42.4 bits (98), Expect = 0.005
Identities = 102/546 (18%), Positives = 223/546 (40%), Gaps = 84/546 (15%)
Query: 814 IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
+K + KS A +K + K Q++ + ++ + + ++ + +T++ +WQ ++
Sbjct: 2505 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2564
Query: 872 KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
+ R LE+ L ++ +WL + + L + D N LN Q+
Sbjct: 2565 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2619
Query: 932 NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
++VQ + + A YE T+ + +L+ P + ++ G+
Sbjct: 2620 -------------QQVQILLQEFATRKPQYE----QLTAAGQGILSRPGEDPSLR---GI 2659
Query: 992 ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSEN 1051
+ ++ A V ++ L + LS+ ++ +K+T+ + L LR D S+
Sbjct: 2660 VKEQLAAVTQKWDSLTGQ-------LSDRCDWIDQAIVKSTQYQSL---LRSLSDKLSDL 2709
Query: 1052 CNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKI 1111
NK L +L +L + +++K++ + + K K C + E+
Sbjct: 2710 DNK---LSSSL-AVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2765
Query: 1112 TR--LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-------RQCEKENLGWQKLESEK 1162
+ L+ ++E + K VE + +N LQ A +Q ++ W L+++K
Sbjct: 2766 LKAELSRQLEGILKSFKDVEQK---AENHVQHLQSACASSHQFQQMSRDFQAW--LDTKK 2820
Query: 1163 AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKV 1222
+ K + I +L+ +++ L S+ +++ + E E+LL+K +
Sbjct: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT-------IAEGENLLLKTQG 2873
Query: 1223 LEQDKARLQ-------------RLEDELNRAKSTLEAETRVKQRLECEKQQI---QNDLN 1266
E+ +LQ ++++ N+ K +LE + K+++E I QN+L
Sbjct: 2874 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2933
Query: 1267 QWK--TQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE 1324
+ K + E +I K++S ++E + +E L + C E T E
Sbjct: 2934 EIKFCLDPAEGENSIAKLKS----LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDE 2989
Query: 1325 TQSQLE 1330
+S ++
Sbjct: 2990 NKSLIQ 2995
Score = 41.2 bits (95), Expect = 0.012
Identities = 58/293 (19%), Positives = 126/293 (43%), Gaps = 40/293 (13%)
Query: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
KSLED K K + E++ ++ CN A + KA +A+++
Sbjct: 2363 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL----------ISAVTTPAKA-IAAVKS 2411
Query: 1082 LKRQAELDGKSAKQNLDKCYGQ--IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139
A L+G+ N ++ + + + + +T +++ ED K D+ +
Sbjct: 2412 --GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK---DKIAELNTKL 2466
Query: 1140 DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI 1199
+LQKA++ + W + ++ A K ++ ++ + + + +E EL + N++
Sbjct: 2467 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2526
Query: 1200 QESKNQCTQVVQER---------ESLLVKIKVLEQDKARL-----QRLEDELNRAKSTLE 1245
QE K++ T++++E + +L +I Q+ +L Q+LE+ N
Sbjct: 2527 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2586
Query: 1246 AETRVKQRLECEKQ-------QIQNDLNQWKTQYSRKEEAIRKIESEREKSER 1291
E ++KQ L EK+ + D N TQ + + +++ + + + E+
Sbjct: 2587 VEAQLKQWL-VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2638
Score = 35.8 bits (81), Expect = 0.49
Identities = 16/28 (57%), Positives = 22/28 (78%)
Query: 2223 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2250
A ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 5450 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5477
Score = 35.4 bits (80), Expect = 0.64
Identities = 16/27 (59%), Positives = 20/27 (74%)
Query: 2226 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2252
SR GSR+GS++GSR+ SR GS FD
Sbjct: 5457 SRPGSRAGSKAGSRASSRRGSDASDFD 5483
Score = 33.1 bits (74), Expect = 3.2
Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)
Query: 2199 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2242
+GL AA V ++ S S PGSR+GS++GSR+ SR GS
Sbjct: 5435 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5477
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 577 bits (1488), Expect = e-164
Identities = 350/1260 (27%), Positives = 651/1260 (51%), Gaps = 131/1260 (10%)
Query: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
+E + L W+ + + ++D WG DL SVE H+ +H+ +H +I ++ L + K
Sbjct: 779 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 838
Query: 241 DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
+ +A +++LE +Y LL S + HL L N + + E++W+N+ EE
Sbjct: 839 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 898
Query: 292 EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
EE+ YDWS++NTNIA+K++ + M +L+ KE+ + +++ ++QL+L HPA IEAY
Sbjct: 899 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 958
Query: 352 DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
+QTQWSWILQ+ +C++ H+KEN AYF+FF +A+ YL+ L+D+I++KY CD++ +
Sbjct: 959 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 1018
Query: 412 QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
L + ++E +E+E++L+YK + NL+ K+K I+QLKPRN D I ++A+CDY+Q
Sbjct: 1019 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 1078
Query: 472 DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
+ ++K DEC+L +N+ R+KW V P G + +VPSV +PPPN AVDL+ +IEQ Y+
Sbjct: 1079 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1138
Query: 532 AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
+L LW++ +INMKS+VSWHY + +I++IRA +A +KTM ++ + +++L+ +++F+
Sbjct: 1139 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1198
Query: 592 RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
+SQ S++F D +++ + +++YQ L+
Sbjct: 1199 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1230
Query: 652 NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
K E + + + E++ IR ++E+CE R+ + ++ H +I E +
Sbjct: 1231 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1289
Query: 712 VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
++ + + + + + N+ ++ + S L++E+ + Q + + ++ Y++ L
Sbjct: 1290 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1349
Query: 768 CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
TV +L+ E ++K+YE +L EEE V D + +E LK+ +++++ K+ +
Sbjct: 1350 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1409
Query: 828 MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
++ ELQKA+ I + + Y DLD EK QL +RWQ + QID RL DLE K
Sbjct: 1410 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1469
Query: 888 LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
L+ YRD Y W+ + Q ++ + +S T+ LN+QK L SEI K+ K +E
Sbjct: 1470 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1529
Query: 948 QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
QK AE + ++KDYELQ +Y + +++ P+KR +QS + +I+QE D+ RY L+
Sbjct: 1530 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1589
Query: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLE-------------EELRLARDANSENC 1052
T Y +F + LK L E+ L+ K E +E + L+ A A
Sbjct: 1590 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1649
Query: 1053 NKNKFLDQNLQKYQAECSQ-------FKAKLAS--LEELKRQAELDGKSAKQNLDKCYGQ 1103
+K K + + + + S+ F AK +E + + E K+ +++ + + +
Sbjct: 1650 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1709
Query: 1104 -IKELNEKITRLTYEIEDE---------KRRRKSVEDRFDQQKNDYDQLQKARQCEKENL 1153
+K+L E T ++E++ K + + + D Q +N Q+A +
Sbjct: 1710 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1769
Query: 1154 GWQKLESEKAIKEKEYE---------IERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
+K +S++ +K+ + ++ L+E G + + + L + ++ E+K
Sbjct: 1770 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKI 1827
Query: 1205 QCTQV------------------VQERESLLVKIKVLEQDKARLQRLEDEL-NRAKSTLE 1245
+C Q+ ++E + +K LE+ K +++ L D L N K +
Sbjct: 1828 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1887
Query: 1246 AETRVKQRLE---------------CEKQQIQNDL------NQWKTQYSRKEEAIRKIES 1284
A T+ KQ +E E+ ++ +L Q T + +K+++
Sbjct: 1888 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1947
Query: 1285 EREKSEREKNSLRSEIERLQAEIKR----IEERCRRKLEDSTRETQSQLETERSRYQREI 1340
+ EK + ++ + Q +++ + + KL+ + +E + ET + ++++
Sbjct: 1948 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 2007
Score = 63.9 bits (154), Expect = 2e-09
Identities = 124/642 (19%), Positives = 249/642 (38%), Gaps = 89/642 (13%)
Query: 836 QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
Q TS Q +DLD + RW+ ++K++ R L++ + ++D
Sbjct: 3443 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3493
Query: 896 QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
++ W+ D + + + + V + EQK L + ++ E +++ E A
Sbjct: 3494 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3552
Query: 956 NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
+ + + QL+ S E LLN R V+ Q+ + E L
Sbjct: 3553 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3605
Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECS 1070
++ + + L + E + T+ LEE++ + + N NK L Q + Q
Sbjct: 3606 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ---- 3658
Query: 1071 QFKAKLASLEELKRQAELDGKSAKQNLDKC-YGQIKELNEKITRLTYE-IEDEKRRRKSV 1128
SL+ L + + D +K + + Y +I+E + + L + + + K +
Sbjct: 3659 -------SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDE 3711
Query: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREY 1188
+ + +D+L K + G K +SE LRVL ++ RK+
Sbjct: 3712 VELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE------------LRVLQEDILLRKQNV 3759
Query: 1189 ENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET 1248
+ L ++++ ++Q++ LE KAR + + TLE
Sbjct: 3760 DQALLNGLELLKQTTGDEVLIIQDK---------LEAIKARYKDITKLSTDVAKTLEQAL 3810
Query: 1249 RVKQRLECEKQQ-------IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS---LRS 1298
++ +RL ++ ++ +L ++TQ + EEA + +E + KN+ L S
Sbjct: 3811 QLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDS 3870
Query: 1299 EIERLQAEIKRIEERCRRKLEDSTRETQSQ---LETERSRYQREIDKLRQRPYGSHRETQ 1355
E A ++ + R R LE E + + ++ EID R +
Sbjct: 3871 LNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3930
Query: 1356 TECEWTVDTSKLVFD----GLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQP 1411
E W +T K + L + T+ QL + KT ++L+ K ++++
Sbjct: 3931 AELSWITETEKKLMSLGDIRLEQDQTSAQLQ----VQKTFTMEILRHKDIIDDLVK---- 3982
Query: 1412 FLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQ 1453
+G + S +EK S+ + K K++ T+ + ++
Sbjct: 3983 ----SGHKIMTACSEEEKQSM-KKKLDKVLKNYDTICQINSE 4019
Score = 53.5 bits (127), Expect = 2e-06
Identities = 145/819 (17%), Positives = 331/819 (40%), Gaps = 130/819 (15%)
Query: 528 QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
QY + + A+++ + I L S D+E ++ I +LK + E Y + I L++
Sbjct: 4363 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4421
Query: 588 QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
Q + + +E + DK +Q + + + +L
Sbjct: 4422 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4453
Query: 648 DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
++I NR++ + + + L ++ + H EG ++ + P+ G I
Sbjct: 4454 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4505
Query: 703 TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
+++ + +QND Q+ E +N+ + L E+ LQN++ L Q+ +N+
Sbjct: 4506 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4565
Query: 760 TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
T+ Q Q + L+ + E E + L E + K +
Sbjct: 4566 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4612
Query: 815 --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
K LN+ + A T K+ +QK QQ+ ++ + + + L +
Sbjct: 4613 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4666
Query: 866 RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
+W+ ++ +++ R LE+ + + ++ Q F WL A++ ++ S +TV+
Sbjct: 4667 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4725
Query: 926 FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
++E K +E++ R++ E+ K L+ S + + N+ I +
Sbjct: 4726 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4773
Query: 986 QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
QS ++Q + + R+ ++ S++++ LE+ + + L+ EL +A
Sbjct: 4774 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4827
Query: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
D + ++ A+ +F+ L + + G+S K+ +K
Sbjct: 4828 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4875
Query: 1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIK 1165
L++ ++ L + + + +++ ++ Q A Q + L ++E + A
Sbjct: 4876 -LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWL--YRVEPQLAED 4932
Query: 1166 EKEY-EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLE 1224
+ + +I+ + L+ + ++ EL K ++ +Q K ++++ +KV
Sbjct: 4933 QPVHGDIDLVMNLIDNH----KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQM 4988
Query: 1225 QDKARLQRLEDELNRAKST-LEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIE 1283
Q+ + L+ +K T LEA R + E + + L +W + E+ +R
Sbjct: 4989 QELSTRWETVCALSISKQTRLEAALRQAE----EFHSVVHALLEW---LAEAEQTLR--- 5038
Query: 1284 SEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDST 1322
++++LR+ I++ + +K++EE+ R +L +T
Sbjct: 5039 -FHGVLPDDEDALRTLIDQHKEFMKKLEEK-RAELNKAT 5075
Score = 52.0 bits (123), Expect = 7e-06
Identities = 132/763 (17%), Positives = 306/763 (40%), Gaps = 86/763 (11%)
Query: 713 QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
QN QA+ L LK ++ +Q+++ + + ++I ++ +L
Sbjct: 3757 QNVDQALLNGLELLKQTTG-----DEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3811
Query: 773 LLQAILQTEDMLKVY----EARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
L + + T + L + E L ET L ++ + K++K + K+LL ++
Sbjct: 3812 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3871
Query: 829 KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888
++ S + P + + V + +R++ + I ++ +++ I +
Sbjct: 3872 N-------EVSSALLELVPWRARE--GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3922
Query: 889 RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
+ + A W+ + +++ SL ++ T + L QK EI +D +++
Sbjct: 3923 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ-LQVQKTFTMEILRHKDIIDDLV 3981
Query: 949 KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
K + + E Q S L+ +L I S + L+ A + ++ E
Sbjct: 3982 KSGHKIMTACSEEEKQ--SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 4039
Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQK 1064
+ ++ L L+ + +EE R R+ +E+ NK Q L+
Sbjct: 4040 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 4099
Query: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED--EK 1122
E + K + + L Q + D K LD+ Q + ++KI ++ +E E+
Sbjct: 4100 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4159
Query: 1123 RRR--------KSVEDRFDQQKN---DYDQLQKARQCEKE--------NLGWQKLESEKA 1163
R+ + ++++ + KN D ++LQ + K+ + G K S KA
Sbjct: 4160 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4219
Query: 1164 IKEKEYEI----ERLRVLLQEEGTRKREYENELAKA----SNRIQESKNQCTQVVQERES 1215
+++K ++ E + L++E + + ELA+ + + +++ E
Sbjct: 4220 VQDKLDQMVFIWENIHTLVEEREAKLLDV-MELAEKFWCDHMSLIVTIKDTQDFIRDLED 4278
Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-----ECEKQQIQNDLNQ--- 1267
+ V++Q + + + +E++ + L+ + L E +K ++ +++
Sbjct: 4279 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4338
Query: 1268 -WKTQYSRKEEAIRKIESEREKSEREKNSLR-------------SEIERLQAEIKRIEER 1313
W + ++ I K+E + + + ++ L+ + + + +++ ++++
Sbjct: 4339 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4398
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
+ + Q Q+E ER +Q E+ L++ S + T + + KL++D L
Sbjct: 4399 IEELKQFKSEAYQQQIEMERLNHQAEL-LLKKVTEESDKHTVQD---PLMELKLIWDSLE 4454
Query: 1374 KKVTAMQ-LYECQLID----KTTLDKLLKGKKSVEEVASEIQP 1411
+++ Q E L+ + LD+LL E + SE +P
Sbjct: 4455 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4497
Score = 50.1 bits (118), Expect = 3e-05
Identities = 99/551 (17%), Positives = 224/551 (40%), Gaps = 68/551 (12%)
Query: 773 LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832
L Q + + L+ LT+ +TV L + + + + L++ ++L T + ++
Sbjct: 2701 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQV 2760
Query: 833 QKAQQIHSQTSQQY-------------PLYDLDL-GKFGEKVTQLTDRWQRIDKQIDFRL 878
Q Q + QY P D L G E++ +T +W + Q+ R
Sbjct: 2761 QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRC 2820
Query: 879 WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
+++ I + Y+ ++ L D + S ++ + + + L + + EI
Sbjct: 2821 DWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST-HPDAMNQQLETAQKMKQEIQ 2879
Query: 939 GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
++ + + Q + E + +K+ L+ A + LE +L S +++ A+
Sbjct: 2880 QEKKQIKVAQALCEDLSALVKEEYLK-AELSRQLEGILK-----------SFKDVEQKAE 2927
Query: 999 VHARYIELLTRSGDYYRFLSEMLKSLEDLKLK--------NTKIEVLEEELRLARDANSE 1050
H ++++ S ++ +S ++ D K + + K++VLE ++ +D +
Sbjct: 2928 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2987
Query: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEK 1110
++ ++ + AE K E+ Q +L+ + K N D Q+KE K
Sbjct: 2988 LTAQSHMYEKTI----AEGENLLLKTQGSEKAALQLQLN--TIKTNWDTFNKQVKERENK 3041
Query: 1111 ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAI-KEKEY 1169
+ +E + ++ VE + + L++ + C G + K++ KE +
Sbjct: 3042 LKE---SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 3098
Query: 1170 EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIK-VLEQDKA 1228
+ +L N A + + E + V E +SL+ K+ V EQ +
Sbjct: 3099 HFGMVELL------------NNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHS 3144
Query: 1229 RLQRLEDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIR 1280
+ LE+ + K E K++L+C K+Q+ Q N++ T ++++++
Sbjct: 3145 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3204
Query: 1281 KIESEREKSER 1291
++ + + ++R
Sbjct: 3205 ALKHQVDLAKR 3215
Score = 48.5 bits (114), Expect = 7e-05
Identities = 140/703 (19%), Positives = 270/703 (38%), Gaps = 92/703 (13%)
Query: 674 KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
KI + +E E + P + I +I+E K+V D + + + LK +M
Sbjct: 4145 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4204
Query: 730 LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
+A G++K +Q+++ + ENI+ + + L C +L+
Sbjct: 4205 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4264
Query: 776 AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
I T+D ++ E + V + E R + ++ +L++ +L +
Sbjct: 4265 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4315
Query: 836 QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
+ I + P+ + + +L W ++K R+ LE+ ++ Y+D
Sbjct: 4316 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4368
Query: 896 QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
QA W+ A + S+ + D TV + + E K SE ++ + E + AEL
Sbjct: 4369 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4427
Query: 955 --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
++++D ++L LE + I R G +L HA EL
Sbjct: 4428 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4481
Query: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
L LSE D ++++ K VL+ ++ LA + E NK N ++ +
Sbjct: 4482 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4540
Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
+ E S + KL L + + + KQ LD Q K + +I L + D
Sbjct: 4541 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4597
Query: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
+R V F+ ++ Y L QK +Q +
Sbjct: 4598 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4657
Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQV-----VQERES 1215
++ I + + E + L E T+ E N + N +Q+ N TQ V R S
Sbjct: 4658 DQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPS 4717
Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ---IQNDL----NQW 1268
L++ + + D+ ++ E +R + +T + +KQ I+N L ++W
Sbjct: 4718 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4777
Query: 1269 KTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1311
+ R E R ++ R+++++ + +E L+ K ++
Sbjct: 4778 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4820
Score = 43.1 bits (100), Expect = 0.003
Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)
Query: 198 QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
Q AE V +DL V I++H+ +G + +K RE K
Sbjct: 4928 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4985
Query: 246 SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
+ +L +E + S + L RQ + + W+ + E+ +L D
Sbjct: 4986 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 5045
Query: 298 WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
D + + + F M +LE K ELNK D ++ HP S I+ ++ ++
Sbjct: 5046 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 5102
Query: 357 QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
++ +L K L +A + + EA L LQ + DK + Q +E
Sbjct: 5103 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 5159
Query: 417 QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
++K L E + +E + Q V+K K + + +P +S+ P++ + K+
Sbjct: 5160 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5219
Query: 474 KIVHKGDECILKDNNER-----SKW 493
+ G + ++ N R SKW
Sbjct: 5220 SLYPSGSQTQIETKNPRVNLLVSKW 5244
Score = 42.4 bits (98), Expect = 0.005
Identities = 102/546 (18%), Positives = 223/546 (40%), Gaps = 84/546 (15%)
Query: 814 IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
+K + KS A +K + K Q++ + ++ + + ++ + +T++ +WQ ++
Sbjct: 2643 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2702
Query: 872 KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
+ R LE+ L ++ +WL + + L + D N LN Q+
Sbjct: 2703 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2757
Query: 932 NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
++VQ + + A YE T+ + +L+ P + ++ G+
Sbjct: 2758 -------------QQVQILLQEFATRKPQYE----QLTAAGQGILSRPGEDPSLR---GI 2797
Query: 992 ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSEN 1051
+ ++ A V ++ L + LS+ ++ +K+T+ + L LR D S+
Sbjct: 2798 VKEQLAAVTQKWDSLTGQ-------LSDRCDWIDQAIVKSTQYQSL---LRSLSDKLSDL 2847
Query: 1052 CNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKI 1111
NK L +L +L + +++K++ + + K K C + E+
Sbjct: 2848 DNK---LSSSL-AVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2903
Query: 1112 TR--LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-------RQCEKENLGWQKLESEK 1162
+ L+ ++E + K VE + +N LQ A +Q ++ W L+++K
Sbjct: 2904 LKAELSRQLEGILKSFKDVEQK---AENHVQHLQSACASSHQFQQMSRDFQAW--LDTKK 2958
Query: 1163 AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKV 1222
+ K + I +L+ +++ L S+ +++ + E E+LL+K +
Sbjct: 2959 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT-------IAEGENLLLKTQG 3011
Query: 1223 LEQDKARLQ-------------RLEDELNRAKSTLEAETRVKQRLECEKQQI---QNDLN 1266
E+ +LQ ++++ N+ K +LE + K+++E I QN+L
Sbjct: 3012 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 3071
Query: 1267 QWK--TQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE 1324
+ K + E +I K++S ++E + +E L + C E T E
Sbjct: 3072 EIKFCLDPAEGENSIAKLKS----LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDE 3127
Query: 1325 TQSQLE 1330
+S ++
Sbjct: 3128 NKSLIQ 3133
Score = 41.2 bits (95), Expect = 0.012
Identities = 58/293 (19%), Positives = 126/293 (43%), Gaps = 40/293 (13%)
Query: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
KSLED K K + E++ ++ CN A + KA +A+++
Sbjct: 2501 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL----------ISAVTTPAKA-IAAVKS 2549
Query: 1082 LKRQAELDGKSAKQNLDKCYGQ--IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139
A L+G+ N ++ + + + + +T +++ ED K D+ +
Sbjct: 2550 --GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK---DKIAELNTKL 2604
Query: 1140 DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI 1199
+LQKA++ + W + ++ A K ++ ++ + + + +E EL + N++
Sbjct: 2605 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2664
Query: 1200 QESKNQCTQVVQER---------ESLLVKIKVLEQDKARL-----QRLEDELNRAKSTLE 1245
QE K++ T++++E + +L +I Q+ +L Q+LE+ N
Sbjct: 2665 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2724
Query: 1246 AETRVKQRLECEKQ-------QIQNDLNQWKTQYSRKEEAIRKIESEREKSER 1291
E ++KQ L EK+ + D N TQ + + +++ + + + E+
Sbjct: 2725 VEAQLKQWL-VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2776
Score = 35.8 bits (81), Expect = 0.49
Identities = 16/28 (57%), Positives = 22/28 (78%)
Query: 2223 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2250
A ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 5588 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5615
Score = 35.4 bits (80), Expect = 0.64
Identities = 16/27 (59%), Positives = 20/27 (74%)
Query: 2226 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2252
SR GSR+GS++GSR+ SR GS FD
Sbjct: 5595 SRPGSRAGSKAGSRASSRRGSDASDFD 5621
Score = 33.1 bits (74), Expect = 3.2
Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)
Query: 2199 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2242
+GL AA V ++ S S PGSR+GS++GSR+ SR GS
Sbjct: 5573 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5615
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 577 bits (1488), Expect = e-164
Identities = 350/1260 (27%), Positives = 651/1260 (51%), Gaps = 131/1260 (10%)
Query: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
+E + L W+ + + ++D WG DL SVE H+ +H+ +H +I ++ L + K
Sbjct: 601 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660
Query: 241 DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
+ +A +++LE +Y LL S + HL L N + + E++W+N+ EE
Sbjct: 661 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720
Query: 292 EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
EE+ YDWS++NTNIA+K++ + M +L+ KE+ + +++ ++QL+L HPA IEAY
Sbjct: 721 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780
Query: 352 DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
+QTQWSWILQ+ +C++ H+KEN AYF+FF +A+ YL+ L+D+I++KY CD++ +
Sbjct: 781 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840
Query: 412 QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
L + ++E +E+E++L+YK + NL+ K+K I+QLKPRN D I ++A+CDY+Q
Sbjct: 841 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900
Query: 472 DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
+ ++K DEC+L +N+ R+KW V P G + +VPSV +PPPN AVDL+ +IEQ Y+
Sbjct: 901 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960
Query: 532 AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
+L LW++ +INMKS+VSWHY + +I++IRA +A +KTM ++ + +++L+ +++F+
Sbjct: 961 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020
Query: 592 RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
+SQ S++F D +++ + +++YQ L+
Sbjct: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1052
Query: 652 NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
K E + + + E++ IR ++E+CE R+ + ++ H +I E +
Sbjct: 1053 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1111
Query: 712 VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
++ + + + + + N+ ++ + S L++E+ + Q + + ++ Y++ L
Sbjct: 1112 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1171
Query: 768 CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
TV +L+ E ++K+YE +L EEE V D + +E LK+ +++++ K+ +
Sbjct: 1172 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1231
Query: 828 MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
++ ELQKA+ I + + Y DLD EK QL +RWQ + QID RL DLE K
Sbjct: 1232 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1291
Query: 888 LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
L+ YRD Y W+ + Q ++ + +S T+ LN+QK L SEI K+ K +E
Sbjct: 1292 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1351
Query: 948 QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
QK AE + ++KDYELQ +Y + +++ P+KR +QS + +I+QE D+ RY L+
Sbjct: 1352 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1411
Query: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLE-------------EELRLARDANSENC 1052
T Y +F + LK L E+ L+ K E +E + L+ A A
Sbjct: 1412 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1471
Query: 1053 NKNKFLDQNLQKYQAECSQ-------FKAKLAS--LEELKRQAELDGKSAKQNLDKCYGQ 1103
+K K + + + + S+ F AK +E + + E K+ +++ + + +
Sbjct: 1472 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1531
Query: 1104 -IKELNEKITRLTYEIEDE---------KRRRKSVEDRFDQQKNDYDQLQKARQCEKENL 1153
+K+L E T ++E++ K + + + D Q +N Q+A +
Sbjct: 1532 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1591
Query: 1154 GWQKLESEKAIKEKEYE---------IERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
+K +S++ +K+ + ++ L+E G + + + L + ++ E+K
Sbjct: 1592 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKI 1649
Query: 1205 QCTQV------------------VQERESLLVKIKVLEQDKARLQRLEDEL-NRAKSTLE 1245
+C Q+ ++E + +K LE+ K +++ L D L N K +
Sbjct: 1650 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1709
Query: 1246 AETRVKQRLE---------------CEKQQIQNDL------NQWKTQYSRKEEAIRKIES 1284
A T+ KQ +E E+ ++ +L Q T + +K+++
Sbjct: 1710 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1769
Query: 1285 EREKSEREKNSLRSEIERLQAEIKR----IEERCRRKLEDSTRETQSQLETERSRYQREI 1340
+ EK + ++ + Q +++ + + KL+ + +E + ET + ++++
Sbjct: 1770 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1829
Score = 63.9 bits (154), Expect = 2e-09
Identities = 124/642 (19%), Positives = 249/642 (38%), Gaps = 89/642 (13%)
Query: 836 QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
Q TS Q +DLD + RW+ ++K++ R L++ + ++D
Sbjct: 3265 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3315
Query: 896 QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
++ W+ D + + + + V + EQK L + ++ E +++ E A
Sbjct: 3316 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3374
Query: 956 NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
+ + + QL+ S E LLN R V+ Q+ + E L
Sbjct: 3375 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3427
Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECS 1070
++ + + L + E + T+ LEE++ + + N NK L Q + Q
Sbjct: 3428 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ---- 3480
Query: 1071 QFKAKLASLEELKRQAELDGKSAKQNLDKC-YGQIKELNEKITRLTYE-IEDEKRRRKSV 1128
SL+ L + + D +K + + Y +I+E + + L + + + K +
Sbjct: 3481 -------SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDE 3533
Query: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREY 1188
+ + +D+L K + G K +SE LRVL ++ RK+
Sbjct: 3534 VELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE------------LRVLQEDILLRKQNV 3581
Query: 1189 ENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET 1248
+ L ++++ ++Q++ LE KAR + + TLE
Sbjct: 3582 DQALLNGLELLKQTTGDEVLIIQDK---------LEAIKARYKDITKLSTDVAKTLEQAL 3632
Query: 1249 RVKQRLECEKQQ-------IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS---LRS 1298
++ +RL ++ ++ +L ++TQ + EEA + +E + KN+ L S
Sbjct: 3633 QLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDS 3692
Query: 1299 EIERLQAEIKRIEERCRRKLEDSTRETQSQ---LETERSRYQREIDKLRQRPYGSHRETQ 1355
E A ++ + R R LE E + + ++ EID R +
Sbjct: 3693 LNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3752
Query: 1356 TECEWTVDTSKLVFD----GLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQP 1411
E W +T K + L + T+ QL + KT ++L+ K ++++
Sbjct: 3753 AELSWITETEKKLMSLGDIRLEQDQTSAQLQ----VQKTFTMEILRHKDIIDDLVK---- 3804
Query: 1412 FLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQ 1453
+G + S +EK S+ + K K++ T+ + ++
Sbjct: 3805 ----SGHKIMTACSEEEKQSM-KKKLDKVLKNYDTICQINSE 3841
Score = 53.5 bits (127), Expect = 2e-06
Identities = 145/819 (17%), Positives = 331/819 (40%), Gaps = 130/819 (15%)
Query: 528 QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
QY + + A+++ + I L S D+E ++ I +LK + E Y + I L++
Sbjct: 4185 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4243
Query: 588 QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
Q + + +E + DK +Q + + + +L
Sbjct: 4244 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4275
Query: 648 DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
++I NR++ + + + L ++ + H EG ++ + P+ G I
Sbjct: 4276 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4327
Query: 703 TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
+++ + +QND Q+ E +N+ + L E+ LQN++ L Q+ +N+
Sbjct: 4328 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4387
Query: 760 TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
T+ Q Q + L+ + E E + L E + K +
Sbjct: 4388 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4434
Query: 815 --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
K LN+ + A T K+ +QK QQ+ ++ + + + L +
Sbjct: 4435 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4488
Query: 866 RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
+W+ ++ +++ R LE+ + + ++ Q F WL A++ ++ S +TV+
Sbjct: 4489 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4547
Query: 926 FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
++E K +E++ R++ E+ K L+ S + + N+ I +
Sbjct: 4548 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4595
Query: 986 QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
QS ++Q + + R+ ++ S++++ LE+ + + L+ EL +A
Sbjct: 4596 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4649
Query: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
D + ++ A+ +F+ L + + G+S K+ +K
Sbjct: 4650 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4697
Query: 1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIK 1165
L++ ++ L + + + +++ ++ Q A Q + L ++E + A
Sbjct: 4698 -LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWL--YRVEPQLAED 4754
Query: 1166 EKEY-EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLE 1224
+ + +I+ + L+ + ++ EL K ++ +Q K ++++ +KV
Sbjct: 4755 QPVHGDIDLVMNLIDNH----KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQM 4810
Query: 1225 QDKARLQRLEDELNRAKST-LEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIE 1283
Q+ + L+ +K T LEA R + E + + L +W + E+ +R
Sbjct: 4811 QELSTRWETVCALSISKQTRLEAALRQAE----EFHSVVHALLEW---LAEAEQTLR--- 4860
Query: 1284 SEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDST 1322
++++LR+ I++ + +K++EE+ R +L +T
Sbjct: 4861 -FHGVLPDDEDALRTLIDQHKEFMKKLEEK-RAELNKAT 4897
Score = 52.0 bits (123), Expect = 7e-06
Identities = 132/763 (17%), Positives = 306/763 (40%), Gaps = 86/763 (11%)
Query: 713 QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
QN QA+ L LK ++ +Q+++ + + ++I ++ +L
Sbjct: 3579 QNVDQALLNGLELLKQTTG-----DEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3633
Query: 773 LLQAILQTEDMLKVY----EARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
L + + T + L + E L ET L ++ + K++K + K+LL ++
Sbjct: 3634 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3693
Query: 829 KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888
++ S + P + + V + +R++ + I ++ +++ I +
Sbjct: 3694 N-------EVSSALLELVPWRARE--GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3744
Query: 889 RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
+ + A W+ + +++ SL ++ T + L QK EI +D +++
Sbjct: 3745 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ-LQVQKTFTMEILRHKDIIDDLV 3803
Query: 949 KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
K + + E Q S L+ +L I S + L+ A + ++ E
Sbjct: 3804 KSGHKIMTACSEEEKQ--SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3861
Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQK 1064
+ ++ L L+ + +EE R R+ +E+ NK Q L+
Sbjct: 3862 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3921
Query: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED--EK 1122
E + K + + L Q + D K LD+ Q + ++KI ++ +E E+
Sbjct: 3922 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3981
Query: 1123 RRR--------KSVEDRFDQQKN---DYDQLQKARQCEKE--------NLGWQKLESEKA 1163
R+ + ++++ + KN D ++LQ + K+ + G K S KA
Sbjct: 3982 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4041
Query: 1164 IKEKEYEI----ERLRVLLQEEGTRKREYENELAKA----SNRIQESKNQCTQVVQERES 1215
+++K ++ E + L++E + + ELA+ + + +++ E
Sbjct: 4042 VQDKLDQMVFIWENIHTLVEEREAKLLDV-MELAEKFWCDHMSLIVTIKDTQDFIRDLED 4100
Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-----ECEKQQIQNDLNQ--- 1267
+ V++Q + + + +E++ + L+ + L E +K ++ +++
Sbjct: 4101 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4160
Query: 1268 -WKTQYSRKEEAIRKIESEREKSEREKNSLR-------------SEIERLQAEIKRIEER 1313
W + ++ I K+E + + + ++ L+ + + + +++ ++++
Sbjct: 4161 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4220
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
+ + Q Q+E ER +Q E+ L++ S + T + + KL++D L
Sbjct: 4221 IEELKQFKSEAYQQQIEMERLNHQAEL-LLKKVTEESDKHTVQD---PLMELKLIWDSLE 4276
Query: 1374 KKVTAMQ-LYECQLID----KTTLDKLLKGKKSVEEVASEIQP 1411
+++ Q E L+ + LD+LL E + SE +P
Sbjct: 4277 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4319
Score = 50.1 bits (118), Expect = 3e-05
Identities = 99/551 (17%), Positives = 224/551 (40%), Gaps = 68/551 (12%)
Query: 773 LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832
L Q + + L+ LT+ +TV L + + + + L++ ++L T + ++
Sbjct: 2523 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQV 2582
Query: 833 QKAQQIHSQTSQQY-------------PLYDLDL-GKFGEKVTQLTDRWQRIDKQIDFRL 878
Q Q + QY P D L G E++ +T +W + Q+ R
Sbjct: 2583 QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRC 2642
Query: 879 WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
+++ I + Y+ ++ L D + S ++ + + + L + + EI
Sbjct: 2643 DWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST-HPDAMNQQLETAQKMKQEIQ 2701
Query: 939 GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
++ + + Q + E + +K+ L+ A + LE +L S +++ A+
Sbjct: 2702 QEKKQIKVAQALCEDLSALVKEEYLK-AELSRQLEGILK-----------SFKDVEQKAE 2749
Query: 999 VHARYIELLTRSGDYYRFLSEMLKSLEDLKLK--------NTKIEVLEEELRLARDANSE 1050
H ++++ S ++ +S ++ D K + + K++VLE ++ +D +
Sbjct: 2750 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2809
Query: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEK 1110
++ ++ + AE K E+ Q +L+ + K N D Q+KE K
Sbjct: 2810 LTAQSHMYEKTI----AEGENLLLKTQGSEKAALQLQLN--TIKTNWDTFNKQVKERENK 2863
Query: 1111 ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAI-KEKEY 1169
+ +E + ++ VE + + L++ + C G + K++ KE +
Sbjct: 2864 LKE---SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2920
Query: 1170 EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIK-VLEQDKA 1228
+ +L N A + + E + V E +SL+ K+ V EQ +
Sbjct: 2921 HFGMVELL------------NNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHS 2966
Query: 1229 RLQRLEDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIR 1280
+ LE+ + K E K++L+C K+Q+ Q N++ T ++++++
Sbjct: 2967 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3026
Query: 1281 KIESEREKSER 1291
++ + + ++R
Sbjct: 3027 ALKHQVDLAKR 3037
Score = 48.5 bits (114), Expect = 7e-05
Identities = 140/703 (19%), Positives = 270/703 (38%), Gaps = 92/703 (13%)
Query: 674 KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
KI + +E E + P + I +I+E K+V D + + + LK +M
Sbjct: 3967 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4026
Query: 730 LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
+A G++K +Q+++ + ENI+ + + L C +L+
Sbjct: 4027 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4086
Query: 776 AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
I T+D ++ E + V + E R + ++ +L++ +L +
Sbjct: 4087 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4137
Query: 836 QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
+ I + P+ + + +L W ++K R+ LE+ ++ Y+D
Sbjct: 4138 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4190
Query: 896 QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
QA W+ A + S+ + D TV + + E K SE ++ + E + AEL
Sbjct: 4191 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4249
Query: 955 --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
++++D ++L LE + I R G +L HA EL
Sbjct: 4250 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4303
Query: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
L LSE D ++++ K VL+ ++ LA + E NK N ++ +
Sbjct: 4304 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4362
Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
+ E S + KL L + + + KQ LD Q K + +I L + D
Sbjct: 4363 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4419
Query: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
+R V F+ ++ Y L QK +Q +
Sbjct: 4420 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4479
Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQV-----VQERES 1215
++ I + + E + L E T+ E N + N +Q+ N TQ V R S
Sbjct: 4480 DQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPS 4539
Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ---IQNDL----NQW 1268
L++ + + D+ ++ E +R + +T + +KQ I+N L ++W
Sbjct: 4540 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599
Query: 1269 KTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1311
+ R E R ++ R+++++ + +E L+ K ++
Sbjct: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4642
Score = 43.1 bits (100), Expect = 0.003
Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)
Query: 198 QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
Q AE V +DL V I++H+ +G + +K RE K
Sbjct: 4750 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807
Query: 246 SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
+ +L +E + S + L RQ + + W+ + E+ +L D
Sbjct: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867
Query: 298 WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
D + + + F M +LE K ELNK D ++ HP S I+ ++ ++
Sbjct: 4868 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4924
Query: 357 QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
++ +L K L +A + + EA L LQ + DK + Q +E
Sbjct: 4925 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 4981
Query: 417 QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
++K L E + +E + Q V+K K + + +P +S+ P++ + K+
Sbjct: 4982 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5041
Query: 474 KIVHKGDECILKDNNER-----SKW 493
+ G + ++ N R SKW
Sbjct: 5042 SLYPSGSQTQIETKNPRVNLLVSKW 5066
Score = 42.4 bits (98), Expect = 0.005
Identities = 102/546 (18%), Positives = 223/546 (40%), Gaps = 84/546 (15%)
Query: 814 IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
+K + KS A +K + K Q++ + ++ + + ++ + +T++ +WQ ++
Sbjct: 2465 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2524
Query: 872 KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
+ R LE+ L ++ +WL + + L + D N LN Q+
Sbjct: 2525 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2579
Query: 932 NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
++VQ + + A YE T+ + +L+ P + ++ G+
Sbjct: 2580 -------------QQVQILLQEFATRKPQYE----QLTAAGQGILSRPGEDPSLR---GI 2619
Query: 992 ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSEN 1051
+ ++ A V ++ L + LS+ ++ +K+T+ + L LR D S+
Sbjct: 2620 VKEQLAAVTQKWDSLTGQ-------LSDRCDWIDQAIVKSTQYQSL---LRSLSDKLSDL 2669
Query: 1052 CNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKI 1111
NK L +L +L + +++K++ + + K K C + E+
Sbjct: 2670 DNK---LSSSL-AVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2725
Query: 1112 TR--LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-------RQCEKENLGWQKLESEK 1162
+ L+ ++E + K VE + +N LQ A +Q ++ W L+++K
Sbjct: 2726 LKAELSRQLEGILKSFKDVEQK---AENHVQHLQSACASSHQFQQMSRDFQAW--LDTKK 2780
Query: 1163 AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKV 1222
+ K + I +L+ +++ L S+ +++ + E E+LL+K +
Sbjct: 2781 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT-------IAEGENLLLKTQG 2833
Query: 1223 LEQDKARLQ-------------RLEDELNRAKSTLEAETRVKQRLECEKQQI---QNDLN 1266
E+ +LQ ++++ N+ K +LE + K+++E I QN+L
Sbjct: 2834 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2893
Query: 1267 QWK--TQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE 1324
+ K + E +I K++S ++E + +E L + C E T E
Sbjct: 2894 EIKFCLDPAEGENSIAKLKS----LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDE 2949
Query: 1325 TQSQLE 1330
+S ++
Sbjct: 2950 NKSLIQ 2955
Score = 41.2 bits (95), Expect = 0.012
Identities = 58/293 (19%), Positives = 126/293 (43%), Gaps = 40/293 (13%)
Query: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
KSLED K K + E++ ++ CN A + KA +A+++
Sbjct: 2323 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL----------ISAVTTPAKA-IAAVKS 2371
Query: 1082 LKRQAELDGKSAKQNLDKCYGQ--IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139
A L+G+ N ++ + + + + +T +++ ED K D+ +
Sbjct: 2372 --GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK---DKIAELNTKL 2426
Query: 1140 DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI 1199
+LQKA++ + W + ++ A K ++ ++ + + + +E EL + N++
Sbjct: 2427 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2486
Query: 1200 QESKNQCTQVVQER---------ESLLVKIKVLEQDKARL-----QRLEDELNRAKSTLE 1245
QE K++ T++++E + +L +I Q+ +L Q+LE+ N
Sbjct: 2487 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2546
Query: 1246 AETRVKQRLECEKQ-------QIQNDLNQWKTQYSRKEEAIRKIESEREKSER 1291
E ++KQ L EK+ + D N TQ + + +++ + + + E+
Sbjct: 2547 VEAQLKQWL-VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2598
Score = 35.8 bits (81), Expect = 0.49
Identities = 16/28 (57%), Positives = 22/28 (78%)
Query: 2223 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2250
A ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 5410 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5437
Score = 35.4 bits (80), Expect = 0.64
Identities = 16/27 (59%), Positives = 20/27 (74%)
Query: 2226 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2252
SR GSR+GS++GSR+ SR GS FD
Sbjct: 5417 SRPGSRAGSKAGSRASSRRGSDASDFD 5443
Score = 33.1 bits (74), Expect = 3.2
Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)
Query: 2199 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2242
+GL AA V ++ S S PGSR+GS++GSR+ SR GS
Sbjct: 5395 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5437
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 577 bits (1488), Expect = e-164
Identities = 350/1260 (27%), Positives = 651/1260 (51%), Gaps = 131/1260 (10%)
Query: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
+E + L W+ + + ++D WG DL SVE H+ +H+ +H +I ++ L + K
Sbjct: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334
Query: 241 DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
+ +A +++LE +Y LL S + HL L N + + E++W+N+ EE
Sbjct: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394
Query: 292 EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
EE+ YDWS++NTNIA+K++ + M +L+ KE+ + +++ ++QL+L HPA IEAY
Sbjct: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454
Query: 352 DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
+QTQWSWILQ+ +C++ H+KEN AYF+FF +A+ YL+ L+D+I++KY CD++ +
Sbjct: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514
Query: 412 QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
L + ++E +E+E++L+YK + NL+ K+K I+QLKPRN D I ++A+CDY+Q
Sbjct: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574
Query: 472 DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
+ ++K DEC+L +N+ R+KW V P G + +VPSV +PPPN AVDL+ +IEQ Y+
Sbjct: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634
Query: 532 AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
+L LW++ +INMKS+VSWHY + +I++IRA +A +KTM ++ + +++L+ +++F+
Sbjct: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694
Query: 592 RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
+SQ S++F D +++ + +++YQ L+
Sbjct: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 726
Query: 652 NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
K E + + + E++ IR ++E+CE R+ + ++ H +I E +
Sbjct: 727 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785
Query: 712 VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
++ + + + + + N+ ++ + S L++E+ + Q + + ++ Y++ L
Sbjct: 786 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845
Query: 768 CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
TV +L+ E ++K+YE +L EEE V D + +E LK+ +++++ K+ +
Sbjct: 846 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 905
Query: 828 MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
++ ELQKA+ I + + Y DLD EK QL +RWQ + QID RL DLE K
Sbjct: 906 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 965
Query: 888 LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
L+ YRD Y W+ + Q ++ + +S T+ LN+QK L SEI K+ K +E
Sbjct: 966 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025
Query: 948 QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
QK AE + ++KDYELQ +Y + +++ P+KR +QS + +I+QE D+ RY L+
Sbjct: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085
Query: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLE-------------EELRLARDANSENC 1052
T Y +F + LK L E+ L+ K E +E + L+ A A
Sbjct: 1086 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1145
Query: 1053 NKNKFLDQNLQKYQAECSQ-------FKAKLAS--LEELKRQAELDGKSAKQNLDKCYGQ 1103
+K K + + + + S+ F AK +E + + E K+ +++ + + +
Sbjct: 1146 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1205
Query: 1104 -IKELNEKITRLTYEIEDE---------KRRRKSVEDRFDQQKNDYDQLQKARQCEKENL 1153
+K+L E T ++E++ K + + + D Q +N Q+A +
Sbjct: 1206 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1265
Query: 1154 GWQKLESEKAIKEKEYE---------IERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
+K +S++ +K+ + ++ L+E G + + + L + ++ E+K
Sbjct: 1266 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKI 1323
Query: 1205 QCTQV------------------VQERESLLVKIKVLEQDKARLQRLEDEL-NRAKSTLE 1245
+C Q+ ++E + +K LE+ K +++ L D L N K +
Sbjct: 1324 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1383
Query: 1246 AETRVKQRLE---------------CEKQQIQNDL------NQWKTQYSRKEEAIRKIES 1284
A T+ KQ +E E+ ++ +L Q T + +K+++
Sbjct: 1384 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1443
Query: 1285 EREKSEREKNSLRSEIERLQAEIKR----IEERCRRKLEDSTRETQSQLETERSRYQREI 1340
+ EK + ++ + Q +++ + + KL+ + +E + ET + ++++
Sbjct: 1444 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1503
Score = 63.9 bits (154), Expect = 2e-09
Identities = 124/642 (19%), Positives = 249/642 (38%), Gaps = 89/642 (13%)
Query: 836 QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
Q TS Q +DLD + RW+ ++K++ R L++ + ++D
Sbjct: 2939 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 2989
Query: 896 QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
++ W+ D + + + + V + EQK L + ++ E +++ E A
Sbjct: 2990 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3048
Query: 956 NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
+ + + QL+ S E LLN R V+ Q+ + E L
Sbjct: 3049 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3101
Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECS 1070
++ + + L + E + T+ LEE++ + + N NK L Q + Q
Sbjct: 3102 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ---- 3154
Query: 1071 QFKAKLASLEELKRQAELDGKSAKQNLDKC-YGQIKELNEKITRLTYE-IEDEKRRRKSV 1128
SL+ L + + D +K + + Y +I+E + + L + + + K +
Sbjct: 3155 -------SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDE 3207
Query: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREY 1188
+ + +D+L K + G K +SE LRVL ++ RK+
Sbjct: 3208 VELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE------------LRVLQEDILLRKQNV 3255
Query: 1189 ENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET 1248
+ L ++++ ++Q++ LE KAR + + TLE
Sbjct: 3256 DQALLNGLELLKQTTGDEVLIIQDK---------LEAIKARYKDITKLSTDVAKTLEQAL 3306
Query: 1249 RVKQRLECEKQQ-------IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS---LRS 1298
++ +RL ++ ++ +L ++TQ + EEA + +E + KN+ L S
Sbjct: 3307 QLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDS 3366
Query: 1299 EIERLQAEIKRIEERCRRKLEDSTRETQSQ---LETERSRYQREIDKLRQRPYGSHRETQ 1355
E A ++ + R R LE E + + ++ EID R +
Sbjct: 3367 LNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3426
Query: 1356 TECEWTVDTSKLVFD----GLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQP 1411
E W +T K + L + T+ QL + KT ++L+ K ++++
Sbjct: 3427 AELSWITETEKKLMSLGDIRLEQDQTSAQLQ----VQKTFTMEILRHKDIIDDLVK---- 3478
Query: 1412 FLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQ 1453
+G + S +EK S+ + K K++ T+ + ++
Sbjct: 3479 ----SGHKIMTACSEEEKQSM-KKKLDKVLKNYDTICQINSE 3515
Score = 53.5 bits (127), Expect = 2e-06
Identities = 145/819 (17%), Positives = 331/819 (40%), Gaps = 130/819 (15%)
Query: 528 QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
QY + + A+++ + I L S D+E ++ I +LK + E Y + I L++
Sbjct: 3859 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 3917
Query: 588 QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
Q + + +E + DK +Q + + + +L
Sbjct: 3918 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 3949
Query: 648 DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
++I NR++ + + + L ++ + H EG ++ + P+ G I
Sbjct: 3950 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4001
Query: 703 TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
+++ + +QND Q+ E +N+ + L E+ LQN++ L Q+ +N+
Sbjct: 4002 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4061
Query: 760 TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
T+ Q Q + L+ + E E + L E + K +
Sbjct: 4062 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4108
Query: 815 --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
K LN+ + A T K+ +QK QQ+ ++ + + + L +
Sbjct: 4109 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4162
Query: 866 RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
+W+ ++ +++ R LE+ + + ++ Q F WL A++ ++ S +TV+
Sbjct: 4163 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4221
Query: 926 FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
++E K +E++ R++ E+ K L+ S + + N+ I +
Sbjct: 4222 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4269
Query: 986 QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
QS ++Q + + R+ ++ S++++ LE+ + + L+ EL +A
Sbjct: 4270 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4323
Query: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
D + ++ A+ +F+ L + + G+S K+ +K
Sbjct: 4324 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4371
Query: 1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIK 1165
L++ ++ L + + + +++ ++ Q A Q + L ++E + A
Sbjct: 4372 -LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWL--YRVEPQLAED 4428
Query: 1166 EKEY-EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLE 1224
+ + +I+ + L+ + ++ EL K ++ +Q K ++++ +KV
Sbjct: 4429 QPVHGDIDLVMNLIDNH----KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQM 4484
Query: 1225 QDKARLQRLEDELNRAKST-LEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIE 1283
Q+ + L+ +K T LEA R + E + + L +W + E+ +R
Sbjct: 4485 QELSTRWETVCALSISKQTRLEAALRQAE----EFHSVVHALLEW---LAEAEQTLR--- 4534
Query: 1284 SEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDST 1322
++++LR+ I++ + +K++EE+ R +L +T
Sbjct: 4535 -FHGVLPDDEDALRTLIDQHKEFMKKLEEK-RAELNKAT 4571
Score = 52.0 bits (123), Expect = 7e-06
Identities = 132/763 (17%), Positives = 306/763 (40%), Gaps = 86/763 (11%)
Query: 713 QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
QN QA+ L LK ++ +Q+++ + + ++I ++ +L
Sbjct: 3253 QNVDQALLNGLELLKQTTG-----DEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3307
Query: 773 LLQAILQTEDMLKVY----EARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
L + + T + L + E L ET L ++ + K++K + K+LL ++
Sbjct: 3308 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3367
Query: 829 KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888
++ S + P + + V + +R++ + I ++ +++ I +
Sbjct: 3368 N-------EVSSALLELVPWRARE--GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3418
Query: 889 RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
+ + A W+ + +++ SL ++ T + L QK EI +D +++
Sbjct: 3419 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ-LQVQKTFTMEILRHKDIIDDLV 3477
Query: 949 KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
K + + E Q S L+ +L I S + L+ A + ++ E
Sbjct: 3478 KSGHKIMTACSEEEKQ--SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3535
Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQK 1064
+ ++ L L+ + +EE R R+ +E+ NK Q L+
Sbjct: 3536 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3595
Query: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED--EK 1122
E + K + + L Q + D K LD+ Q + ++KI ++ +E E+
Sbjct: 3596 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3655
Query: 1123 RRR--------KSVEDRFDQQKN---DYDQLQKARQCEKE--------NLGWQKLESEKA 1163
R+ + ++++ + KN D ++LQ + K+ + G K S KA
Sbjct: 3656 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 3715
Query: 1164 IKEKEYEI----ERLRVLLQEEGTRKREYENELAKA----SNRIQESKNQCTQVVQERES 1215
+++K ++ E + L++E + + ELA+ + + +++ E
Sbjct: 3716 VQDKLDQMVFIWENIHTLVEEREAKLLDV-MELAEKFWCDHMSLIVTIKDTQDFIRDLED 3774
Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-----ECEKQQIQNDLNQ--- 1267
+ V++Q + + + +E++ + L+ + L E +K ++ +++
Sbjct: 3775 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 3834
Query: 1268 -WKTQYSRKEEAIRKIESEREKSEREKNSLR-------------SEIERLQAEIKRIEER 1313
W + ++ I K+E + + + ++ L+ + + + +++ ++++
Sbjct: 3835 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 3894
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
+ + Q Q+E ER +Q E+ L++ S + T + + KL++D L
Sbjct: 3895 IEELKQFKSEAYQQQIEMERLNHQAEL-LLKKVTEESDKHTVQD---PLMELKLIWDSLE 3950
Query: 1374 KKVTAMQ-LYECQLID----KTTLDKLLKGKKSVEEVASEIQP 1411
+++ Q E L+ + LD+LL E + SE +P
Sbjct: 3951 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 3993
Score = 50.1 bits (118), Expect = 3e-05
Identities = 99/551 (17%), Positives = 224/551 (40%), Gaps = 68/551 (12%)
Query: 773 LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832
L Q + + L+ LT+ +TV L + + + + L++ ++L T + ++
Sbjct: 2197 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQV 2256
Query: 833 QKAQQIHSQTSQQY-------------PLYDLDL-GKFGEKVTQLTDRWQRIDKQIDFRL 878
Q Q + QY P D L G E++ +T +W + Q+ R
Sbjct: 2257 QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRC 2316
Query: 879 WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
+++ I + Y+ ++ L D + S ++ + + + L + + EI
Sbjct: 2317 DWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST-HPDAMNQQLETAQKMKQEIQ 2375
Query: 939 GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
++ + + Q + E + +K+ L+ A + LE +L S +++ A+
Sbjct: 2376 QEKKQIKVAQALCEDLSALVKEEYLK-AELSRQLEGILK-----------SFKDVEQKAE 2423
Query: 999 VHARYIELLTRSGDYYRFLSEMLKSLEDLKLK--------NTKIEVLEEELRLARDANSE 1050
H ++++ S ++ +S ++ D K + + K++VLE ++ +D +
Sbjct: 2424 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2483
Query: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEK 1110
++ ++ + AE K E+ Q +L+ + K N D Q+KE K
Sbjct: 2484 LTAQSHMYEKTI----AEGENLLLKTQGSEKAALQLQLN--TIKTNWDTFNKQVKERENK 2537
Query: 1111 ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAI-KEKEY 1169
+ +E + ++ VE + + L++ + C G + K++ KE +
Sbjct: 2538 LKE---SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2594
Query: 1170 EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIK-VLEQDKA 1228
+ +L N A + + E + V E +SL+ K+ V EQ +
Sbjct: 2595 HFGMVELL------------NNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHS 2640
Query: 1229 RLQRLEDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIR 1280
+ LE+ + K E K++L+C K+Q+ Q N++ T ++++++
Sbjct: 2641 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 2700
Query: 1281 KIESEREKSER 1291
++ + + ++R
Sbjct: 2701 ALKHQVDLAKR 2711
Score = 48.5 bits (114), Expect = 7e-05
Identities = 140/703 (19%), Positives = 270/703 (38%), Gaps = 92/703 (13%)
Query: 674 KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
KI + +E E + P + I +I+E K+V D + + + LK +M
Sbjct: 3641 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 3700
Query: 730 LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
+A G++K +Q+++ + ENI+ + + L C +L+
Sbjct: 3701 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 3760
Query: 776 AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
I T+D ++ E + V + E R + ++ +L++ +L +
Sbjct: 3761 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 3811
Query: 836 QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
+ I + P+ + + +L W ++K R+ LE+ ++ Y+D
Sbjct: 3812 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 3864
Query: 896 QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
QA W+ A + S+ + D TV + + E K SE ++ + E + AEL
Sbjct: 3865 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 3923
Query: 955 --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
++++D ++L LE + I R G +L HA EL
Sbjct: 3924 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 3977
Query: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
L LSE D ++++ K VL+ ++ LA + E NK N ++ +
Sbjct: 3978 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4036
Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
+ E S + KL L + + + KQ LD Q K + +I L + D
Sbjct: 4037 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4093
Query: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
+R V F+ ++ Y L QK +Q +
Sbjct: 4094 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4153
Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQV-----VQERES 1215
++ I + + E + L E T+ E N + N +Q+ N TQ V R S
Sbjct: 4154 DQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPS 4213
Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ---IQNDL----NQW 1268
L++ + + D+ ++ E +R + +T + +KQ I+N L ++W
Sbjct: 4214 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4273
Query: 1269 KTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1311
+ R E R ++ R+++++ + +E L+ K ++
Sbjct: 4274 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4316
Score = 43.1 bits (100), Expect = 0.003
Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)
Query: 198 QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
Q AE V +DL V I++H+ +G + +K RE K
Sbjct: 4424 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4481
Query: 246 SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
+ +L +E + S + L RQ + + W+ + E+ +L D
Sbjct: 4482 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4541
Query: 298 WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
D + + + F M +LE K ELNK D ++ HP S I+ ++ ++
Sbjct: 4542 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4598
Query: 357 QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
++ +L K L +A + + EA L LQ + DK + Q +E
Sbjct: 4599 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 4655
Query: 417 QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
++K L E + +E + Q V+K K + + +P +S+ P++ + K+
Sbjct: 4656 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 4715
Query: 474 KIVHKGDECILKDNNER-----SKW 493
+ G + ++ N R SKW
Sbjct: 4716 SLYPSGSQTQIETKNPRVNLLVSKW 4740
Score = 42.4 bits (98), Expect = 0.005
Identities = 102/546 (18%), Positives = 223/546 (40%), Gaps = 84/546 (15%)
Query: 814 IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
+K + KS A +K + K Q++ + ++ + + ++ + +T++ +WQ ++
Sbjct: 2139 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2198
Query: 872 KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
+ R LE+ L ++ +WL + + L + D N LN Q+
Sbjct: 2199 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2253
Query: 932 NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
++VQ + + A YE T+ + +L+ P + ++ G+
Sbjct: 2254 -------------QQVQILLQEFATRKPQYE----QLTAAGQGILSRPGEDPSLR---GI 2293
Query: 992 ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSEN 1051
+ ++ A V ++ L + LS+ ++ +K+T+ + L LR D S+
Sbjct: 2294 VKEQLAAVTQKWDSLTGQ-------LSDRCDWIDQAIVKSTQYQSL---LRSLSDKLSDL 2343
Query: 1052 CNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKI 1111
NK L +L +L + +++K++ + + K K C + E+
Sbjct: 2344 DNK---LSSSL-AVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2399
Query: 1112 TR--LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-------RQCEKENLGWQKLESEK 1162
+ L+ ++E + K VE + +N LQ A +Q ++ W L+++K
Sbjct: 2400 LKAELSRQLEGILKSFKDVEQK---AENHVQHLQSACASSHQFQQMSRDFQAW--LDTKK 2454
Query: 1163 AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKV 1222
+ K + I +L+ +++ L S+ +++ + E E+LL+K +
Sbjct: 2455 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT-------IAEGENLLLKTQG 2507
Query: 1223 LEQDKARLQ-------------RLEDELNRAKSTLEAETRVKQRLECEKQQI---QNDLN 1266
E+ +LQ ++++ N+ K +LE + K+++E I QN+L
Sbjct: 2508 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2567
Query: 1267 QWK--TQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE 1324
+ K + E +I K++S ++E + +E L + C E T E
Sbjct: 2568 EIKFCLDPAEGENSIAKLKS----LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDE 2623
Query: 1325 TQSQLE 1330
+S ++
Sbjct: 2624 NKSLIQ 2629
Score = 41.2 bits (95), Expect = 0.012
Identities = 58/293 (19%), Positives = 126/293 (43%), Gaps = 40/293 (13%)
Query: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
KSLED K K + E++ ++ CN A + KA +A+++
Sbjct: 1997 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL----------ISAVTTPAKA-IAAVKS 2045
Query: 1082 LKRQAELDGKSAKQNLDKCYGQ--IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139
A L+G+ N ++ + + + + +T +++ ED K D+ +
Sbjct: 2046 --GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK---DKIAELNTKL 2100
Query: 1140 DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI 1199
+LQKA++ + W + ++ A K ++ ++ + + + +E EL + N++
Sbjct: 2101 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2160
Query: 1200 QESKNQCTQVVQER---------ESLLVKIKVLEQDKARL-----QRLEDELNRAKSTLE 1245
QE K++ T++++E + +L +I Q+ +L Q+LE+ N
Sbjct: 2161 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2220
Query: 1246 AETRVKQRLECEKQ-------QIQNDLNQWKTQYSRKEEAIRKIESEREKSER 1291
E ++KQ L EK+ + D N TQ + + +++ + + + E+
Sbjct: 2221 VEAQLKQWL-VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2272
Score = 35.8 bits (81), Expect = 0.49
Identities = 16/28 (57%), Positives = 22/28 (78%)
Query: 2223 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2250
A ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 5084 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5111
Score = 35.4 bits (80), Expect = 0.64
Identities = 16/27 (59%), Positives = 20/27 (74%)
Query: 2226 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2252
SR GSR+GS++GSR+ SR GS FD
Sbjct: 5091 SRPGSRAGSKAGSRASSRRGSDASDFD 5117
Score = 33.1 bits (74), Expect = 3.2
Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)
Query: 2199 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2242
+GL AA V ++ S S PGSR+GS++GSR+ SR GS
Sbjct: 5069 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5111
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 516 bits (1328), Expect = e-145
Identities = 365/1351 (27%), Positives = 673/1351 (49%), Gaps = 120/1351 (8%)
Query: 178 SGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDY------ 231
S DE E L W+ + + +++ WG DL SVE + + + IH S+ +
Sbjct: 579 SSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKE 638
Query: 232 -RWQLDKIKADLREKSA--IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIND 288
R K+ + A + +LE +Y L + S RM HL+ L + + E++W+N+
Sbjct: 639 ARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNE 698
Query: 289 CEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIE 348
EEEEL YDWSD N+NI+ K+ FS +LE K+ L+ ++ L L HPA +E
Sbjct: 699 KEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVE 758
Query: 349 AYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKN 408
AY +Q+Q W+ Q+ C++ H+KEN AYFQFF +A+ E++L+ LQDSI++KY CD N
Sbjct: 759 AYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHN 818
Query: 409 MPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCD 468
L L + +++ E+E++++ K V +LV +SK IVQLKPR+PD+ I ++A+CD
Sbjct: 819 TSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCD 878
Query: 469 YKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQ 528
Y+Q + + K DEC+L+DN++R+KW V P G + +VPSV +IPPPN A++++ ++EQ
Sbjct: 879 YRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQ 938
Query: 529 YYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQ 588
Y+ ++ALW+QL++N KSL+SW+Y D++ ++ + KL++ + + + +L+ HY+
Sbjct: 939 SYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYE 998
Query: 589 EFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQD 648
+F+++S+ S +F D+ +++ + + +Q L+ + + +TV I+
Sbjct: 999 DFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYIS------- 1051
Query: 649 VNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLA----DQGSSHHITV 704
EL+ IR ++E E R+ + LA D+ + +
Sbjct: 1052 ----------------------ELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNAL 1089
Query: 705 KINELKSVQNDSQAIAEVLNQLKDMLANFR----GSEKYCYLQNEVFGLFQKLENINGVT 760
+I E + Q D Q + L+ + +F S L++E+ L +K++++ G++
Sbjct: 1090 RIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLS 1149
Query: 761 DGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNL 820
YLN L TV ++++I E ++K YE +L++EE V DL +EA+ L+ +D+
Sbjct: 1150 TVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKD 1209
Query: 821 KKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWD 880
K S+ + + E+ KA+ + Q S+ P +LDL ++ EK +QL +RW R+ Q++ R +
Sbjct: 1210 KNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSE 1269
Query: 881 LEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGK 940
LE + L +YR + KW+ + +Q+ ++ + DS + L++Q L +EI
Sbjct: 1270 LESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERN 1329
Query: 941 RDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVH 1000
+ K ++ QK ++ + +KDYELQL +Y + +E+ P KR + S S I QE D+
Sbjct: 1330 QTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLR 1389
Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKL-----KNTKIEVLEEEL----RLARD----A 1047
RY L+T + + +++S+ L+ LE+ + K +E ++E L LAR+ A
Sbjct: 1390 TRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKA 1449
Query: 1048 NSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKEL 1107
S ++ +++ + + Q + K + E + +++ AK + K++
Sbjct: 1450 TSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI--FLAKHGHKLSEKEKKQI 1507
Query: 1108 NEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQK--ARQCEKENLGWQKLESEKAIK 1165
+E++ L K+ D D N QLQ A Q E++ L Q+ + ++
Sbjct: 1508 SEQLNAL----------NKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE 1557
Query: 1166 EKEYEIERLRVLL--------QEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLL 1217
+ + + L Q++ + ++ +++L + IQ VV++ E +
Sbjct: 1558 DLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFM 1617
Query: 1218 VKIKVLEQDKARLQRLEDELNRAKSTLEA---ETRVKQRLECEKQQIQNDLNQWKTQYSR 1274
+ + + L L ++L++AK EA ETRV Q+ +++ + Q +
Sbjct: 1618 EENQT-KLSPRELTALREKLHQAKEQYEALQEETRVAQK------ELEEAVTSALQQETE 1670
Query: 1275 KEEAIRKIESEREKSEREKN---SLRSEIERLQAEIKRIEERCRRKLEDSTRETQS---- 1327
K +A +++ ++K + + S+ S +L + +E+ LE +T
Sbjct: 1671 KSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMG 1730
Query: 1328 -QLETERSRYQREIDKLRQRPYGSHRE----TQTECEWTVDTSKLVFDGLRKKVTAMQLY 1382
E+ Q E+ K R + S ++ + +D +++ +L
Sbjct: 1731 VNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLG 1790
Query: 1383 ECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKL-- 1440
E + T+L + K V+ + E+Q FL+ KE S +E K+L
Sbjct: 1791 ELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ----------DHKEFESWLERSEKELEN 1840
Query: 1441 -----ISPESTVMLLEAQAATGGIIDPHRNE 1466
SPE+ LL+ Q + + H+ +
Sbjct: 1841 MHKGGSSPETLPSLLKRQGSFSEDVISHKGD 1871
Score = 53.9 bits (128), Expect = 2e-06
Identities = 186/967 (19%), Positives = 376/967 (38%), Gaps = 155/967 (16%)
Query: 415 LEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQK 474
L+Q++ L+ E +K L+ ++ ++ + +S+K ++ + P +L+ + +D
Sbjct: 1807 LKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDV- 1865
Query: 475 IVHKGDECILKDNNER----SKWYVTG--PGGVDMLVPSVGLIIPPPNPLAVDLSC-KIE 527
I HKGD + + ++ + G P + LV L A+ C ++
Sbjct: 1866 ISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK-LKDATERYTALHSKCTRLG 1924
Query: 528 QYYEAILALWNQLYINMKSLVSW-HYCMIDIEKIRAMTIAKLKTMRQEDYMKT------I 580
+ +L ++Q + SL +W C ++EK+ + T+A + QE T +
Sbjct: 1925 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 1984
Query: 581 ADLEL---HYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTT 637
A+ ++ Q+ R+ E D R +Q H+Q+L L + ++
Sbjct: 1985 AEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA---ERSSLLQ 2041
Query: 638 TEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQG 697
I + Q+ + + E + L Q E M LK +A Q
Sbjct: 2042 KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQ-EALATNMKLKQ-DIARQK 2099
Query: 698 SSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKL---- 753
SS T ++ DS A + +L ++ F E+ C Q E +KL
Sbjct: 2100 SSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRF---EQLCLQQQEKESSLKKLLPQA 2156
Query: 754 ---ENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCG 810
E+++G ++ + R L +D+ ++ +++
Sbjct: 2157 EMFEHLSGKLQQFMENKS--RMLASGNQPDQDITHFFQ--------------QIQELNLE 2200
Query: 811 LKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRI 870
++ + +L+ + L+ TEL + LDL + ++V L + +
Sbjct: 2201 MEDQQENLDTLEHLV----TELSSCG------------FALDLCQHQDRVQNLRKDFTEL 2244
Query: 871 DKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQ 930
K + R D +QL +R + F KWL + + E+ + + + +
Sbjct: 2245 QKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM--SAKELEKQIEHL 2302
Query: 931 KNLHSEISGKRDKSEEVQKIAELC-ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPS 989
K+L + + K EE+ C S+++ +++ + S +T +P + + S +
Sbjct: 2303 KSLLDDWASKGTLVEEIN-----CKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVN 2357
Query: 990 GV--------ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDL-KLKNTKIEVLE-- 1038
G I + +DV+ +Y +L + L +L +E++ K N+ ++ LE
Sbjct: 2358 GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK 2417
Query: 1039 EELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLD 1098
EE+ + DA S + +A+ KA LA LE QN
Sbjct: 2418 EEVLKSMDAMSS--------PTKTETVKAQAESNKAFLAELE--------------QNSP 2455
Query: 1099 KCYGQIKELNEKITRL--TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLG-- 1154
K I+++ E + L TY E K +++ + + ++ ARQ + E
Sbjct: 2456 K----IQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASH 2511
Query: 1155 ---WQKLESEKA--IKEKEYEI-----------------ERLRVLLQEEGTRKREYE--N 1190
+Q ES+ + EKE + ++++ +L+E R++++E N
Sbjct: 2512 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLN 2571
Query: 1191 ELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRV 1250
E A+ + T VQ K L+ + L D+LN S ++ + V
Sbjct: 2572 EAAQGILTGPGDVSLSTSQVQ---------KELQSINQKWVELTDKLNSRSSQID-QAIV 2621
Query: 1251 KQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSER---EKNSLRSEIERLQAEI 1307
K + Q++ DL++ ++ I ++ E ++ E + +RS++E+L E+
Sbjct: 2622 KST---QYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 2678
Query: 1308 KRIEERC 1314
K + C
Sbjct: 2679 KEAQTLC 2685
Score = 48.1 bits (113), Expect = 1e-04
Identities = 136/746 (18%), Positives = 280/746 (37%), Gaps = 127/746 (17%)
Query: 709 LKSVQNDSQAIAEVLNQLKDMLANFRGS---EKYCYLQNEVFGLFQKLENINGVTDGYLN 765
L ++ +S I +V L +L + S E + +Q E+ +++ + L
Sbjct: 2447 LAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLE 2506
Query: 766 SLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLL 825
+ A QA E L+ + L E+E + L L N LN +K +
Sbjct: 2507 ESASHLACFQA---AESQLRPW---LMEKELMMGVLGP-------LSIDPNMLNAQKQQV 2553
Query: 826 ATMKTELQKAQQIHSQTSQQYPLY-------DLDLGKFGEKVTQLTDRWQRIDKQIDFRL 878
M E + +Q H Q ++ L + +++ + +W + +++ R
Sbjct: 2554 QFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRS 2613
Query: 879 WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
+++ I + Y++ Q + + +R S++S V + L E + S++
Sbjct: 2614 SQIDQAIVKSTQYQELLQDLSEKVRAVGQRL-SVQSAISTQPEAVKQQLEETSEIRSDLE 2672
Query: 939 GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
+ +E Q + + + I + L+ LET + P + AAD
Sbjct: 2673 QLDHEVKEAQTLCDELSVLIGEQYLK-DELKKRLET----------VALPLQGLEDLAAD 2721
Query: 999 VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFL 1058
R L + + + E+ L+D + + K + +L + EN K L
Sbjct: 2722 RINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSL 2781
Query: 1059 DQNLQKYQAECSQFKAKLAS-------------LEELKRQ-AELDGKSAKQN-------- 1096
+Q+ Y+ ++ ++ L S L ELK EL K+A +
Sbjct: 2782 NQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQ 2841
Query: 1097 ---------------LDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQ 1141
++ C ++ EL ++T ++E R K++ + +++++ +
Sbjct: 2842 KAQKYQWHVEDLVPWIEDCKAKMSEL--RVTLDPVQLESSLLRSKAMLNEVEKRRSLLEI 2899
Query: 1142 LQKAR-------QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAK 1194
L A + +++ + +K + + E++ L+E R RE++
Sbjct: 2900 LNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKN 2959
Query: 1195 ASNRIQESKNQCTQVVQERESLLVKIKVLEQDKAR---LQRLEDE--------------- 1236
+++ +K+Q ++ S K LE+ +A+ LQ LE +
Sbjct: 2960 IEKKVEGAKHQL-EIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDA 3018
Query: 1237 ---------LNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESERE 1287
L++A+ + VKQR+ ++N L + R E ++ +
Sbjct: 3019 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3078
Query: 1288 KSE------REKNSLRSEIER----------LQAEIKRIEERCRRKLEDSTRETQSQLET 1331
+ + R+ +SL+S+IE L+ +I+ E CR LE+ L+
Sbjct: 3079 ELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKR 3138
Query: 1332 ERSRYQREIDKLRQRPYGSHRETQTE 1357
E ++ KL +R G R+ Q E
Sbjct: 3139 ELEALNKQCGKLTER--GKARQEQLE 3162
Score = 48.1 bits (113), Expect = 1e-04
Identities = 113/609 (18%), Positives = 251/609 (41%), Gaps = 84/609 (13%)
Query: 738 KYCYLQNEVFGLFQKLENINGVTDGYLNSLC-----TVRALLQAILQT-EDMLKVYEARL 791
K+ L+N+V +E +N + L S ++R+ L+A+ Q E +L+ E R
Sbjct: 4307 KHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEERE 4366
Query: 792 TEEETVCLDLD----KVEAYRCGLKKIKNDLNLKK---SLLATMKTELQKAQQIHSQTSQ 844
+ ++ ++E + L ++++ L+ K L T + +L +++SQ
Sbjct: 4367 QQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKA 4426
Query: 845 QYPLYD--LDLGKF----------GEKVTQ----LTDRWQRIDKQIDFRLWDLEKQIKQL 888
+ Y+ LD G+ G K Q L +W + +++ R LE+ +
Sbjct: 4427 KEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLA 4486
Query: 889 RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
++++ Q F WL A++ ++ S NTV+ + E K +E++ RD+ E+
Sbjct: 4487 TEFQNSLQEFINWLTLAEQSL-NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELD 4545
Query: 949 KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
+ +L+ S + + N+ + +QS ++Q + + +
Sbjct: 4546 QTGN---------QLKFLSQKQDVVLIKNLLVS---VQSRWEKVVQRSIERGRSLDDARK 4593
Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDAN--SENCNKNKFLDQNLQKYQ 1066
R+ ++ +++ LED + L+ EL ++ D + +K+K + L Q
Sbjct: 4594 RAKQFHEAWKKLIDWLEDAE------SHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQ 4647
Query: 1067 AECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRK 1126
+ + + LK + L S Q LD G++++ + + + E R+
Sbjct: 4648 ---PVYDTTIRTGRALKEKTLLPEDS--QKLDNFLGEVRDKWDTVCGKSVE------RQH 4696
Query: 1127 SVEDRFDQQKNDYDQLQKARQCEKENLGW-QKLESEKAIKEKEYEIERLRVLLQEEGTRK 1185
+E+ D LQ + W K+E + A + + L + L +
Sbjct: 4697 KLEEALLFSGQFMDALQAL-------VDWLYKVEPQLAEDQPVHGDLDLVMNLMD---AH 4746
Query: 1186 REYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNR-AKSTL 1244
+ ++ EL K + +Q K ++++ + K +LQ L + K ++
Sbjct: 4747 KVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV------KGQLQELSTRWDTVCKLSV 4800
Query: 1245 EAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQ 1304
++R++Q L+ + + ++ ++ S E+ +R R + +L+S I+ +
Sbjct: 4801 SKQSRLEQALK-QAEVFRDTVHMLLEWLSEAEQTLR----FRGALPDDTEALQSLIDTHK 4855
Query: 1305 AEIKRIEER 1313
+K++EE+
Sbjct: 4856 EFMKKVEEK 4864
Score = 47.0 bits (110), Expect = 2e-04
Identities = 116/579 (20%), Positives = 238/579 (41%), Gaps = 51/579 (8%)
Query: 858 EKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917
+ + ++ + W+ ++K RL LE ++ Y+D QA WL + + ++ +
Sbjct: 4127 KSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVG- 4185
Query: 918 GDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC---ANSIKDYELQLASYTSGLET 974
D NTV LNE K E+ ++ + E++ EL A D ++ T
Sbjct: 4186 TDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHL 4245
Query: 975 LLNIPIKRTMIQSP-SGVILQEAADVHA--RYIELLTRSGDYYRFLSEMLKSLEDLKLKN 1031
N+ K Q G +L HA + LT + + + + ++++
Sbjct: 4246 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVEL 4305
Query: 1032 TKIEVLEEELRLARDANSENCNK--NKFLDQNLQKYQAECSQFKAKLASLEELKRQAELD 1089
K VL+ ++ LA A E NK N+ L+ + + S +++L ++ +
Sbjct: 4306 AKHHVLKNDV-LAHQATVETVNKAGNELLESSAGD---DASSLRSRLEAMNQC------- 4354
Query: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCE 1149
+S Q ++ Q++ ++ EIED +E + K + AR+
Sbjct: 4355 WESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQL 4414
Query: 1150 KENLGWQKLESEKAIKEKEY----EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQ 1205
++ +L S+ KE+ Y + RL +L +++ + E +A +++ +
Sbjct: 4415 DTHM---ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVA----LLEQKWHV 4467
Query: 1206 CTQVVQERESLLVK-IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQ-- 1262
+ ++ER+S L + + + + + LQ + L A+ +L + L QI+
Sbjct: 4468 VSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEH 4527
Query: 1263 ----NDLNQWKTQYSRKEEAIRKIE--SEREKSEREKNSLRSEIERLQAEIKRIEERCRR 1316
N++N + Q ++ +++ S+++ KN L S R + ++R ER R
Sbjct: 4528 KVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER-GR 4586
Query: 1317 KLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
L+D+ + + E +++ ID L + +E E + D K+ + K
Sbjct: 4587 SLDDARKRAKQFHEA----WKKLIDWLED----AESHLDSELEISNDPDKIKLQLSKHKE 4638
Query: 1377 TAMQLYECQLIDKTTL--DKLLKGKKSVEEVASEIQPFL 1413
L Q + TT+ + LK K + E + ++ FL
Sbjct: 4639 FQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFL 4677
Score = 47.0 bits (110), Expect = 2e-04
Identities = 106/513 (20%), Positives = 197/513 (38%), Gaps = 81/513 (15%)
Query: 801 LDKVEAYRCGLKKIKNDLNLKKSLLATMK---TELQKAQQIHSQTSQQYPLY------DL 851
LD C + + DLN K L MK E+ + Q + + Q L +
Sbjct: 4171 LDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDET 4230
Query: 852 DLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDS 911
D E +T+L W+ + ++I R LE + L ++ + WL + D+
Sbjct: 4231 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA 4290
Query: 912 LESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIA-ELCANSIKDYELQLASYTS 970
+ GD + L + L +++ + E V K EL +S D L S
Sbjct: 4291 QRPIS-GDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLE 4349
Query: 971 GLETLLNIPIKRT-----MIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLE 1025
+ +++T +QS LQ+A H+ +E
Sbjct: 4350 AMNQCWESVLQKTEEREQQLQS----TLQQAQGFHS---------------------EIE 4384
Query: 1026 DLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEEL--K 1083
D L+ T+ +E +L ++ + LD +++ Y SQ KAK + +L K
Sbjct: 4385 DFLLELTR---MESQLSASKPTGGLPETAREQLDTHMELY----SQLKAKEETYNQLLDK 4437
Query: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQ 1143
+ L + + K + L +K ++ ++E+ K + ++ N + Q
Sbjct: 4438 GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK-------SKLEEALNLATEFQ 4490
Query: 1144 KARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI---Q 1200
+ Q E + W L + + VL Q E + + NE+ ++I
Sbjct: 4491 NSLQ---EFINWLTLAEQSLNIASPPSLILNTVLSQIE--EHKVFANEVNAHRDQIIELD 4545
Query: 1201 ESKNQCTQVVQERESLLVK----------IKVLEQDKARLQRLEDELNRAKSTLEAETRV 1250
++ NQ + Q+++ +L+K KV+++ R + L+D RAK EA ++
Sbjct: 4546 QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKL 4605
Query: 1251 KQRLECEKQ------QIQNDLNQWKTQYSRKEE 1277
LE + +I ND ++ K Q S+ +E
Sbjct: 4606 IDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 4638
Score = 44.7 bits (104), Expect = 0.001
Identities = 113/627 (18%), Positives = 238/627 (37%), Gaps = 78/627 (12%)
Query: 850 DLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQ 909
D D+ + ++ RW ++K++ R+ L++ + ++D + WL D +
Sbjct: 3241 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3300
Query: 910 DSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYT 969
+ + + V + EQK L + ++ + +Q A S +LA
Sbjct: 3301 AN-QKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS-----AELADRE 3354
Query: 970 SGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKL 1029
L ++ + T + S + ++ D+ + + FLS K L + +
Sbjct: 3355 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP 3414
Query: 1030 KNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELD 1089
T+ +++++ ++K L+++++ + + Q SL L AE
Sbjct: 3415 VGTQTAKIQQQI-----------IRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-- 3461
Query: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR--- 1146
G + E + + EI+D R+ ++ D+ L AR
Sbjct: 3462 -----------QGVLSEKIDSLQARYSEIQDRCCRKAALLDQ---------ALSNARLFG 3501
Query: 1147 QCEKENLGWQKLESEK--AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
+ E E L W +K ++ K+++ + L + E N I+ +
Sbjct: 3502 EDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQA 3561
Query: 1205 QCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQND 1264
Q E E LL++ K L+ K R + ++A TLE ++ + + +++
Sbjct: 3562 LLKQTTGE-EVLLIQEK-LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW 3619
Query: 1265 LNQWKTQ------YSRKEEAIRKIESEREKSEREKNSLR------SEIERLQAEIK--RI 1310
L + + + S E I + + +++ ++E R +E+ R E+ R
Sbjct: 3620 LREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRA 3679
Query: 1311 EERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTS-KLVF 1369
E + + D+ + + +T R EID QR + E W +T KL+
Sbjct: 3680 REGLDKLVSDANEQYKLVSDTIGQRVD-EIDAAIQRSQQYEQAADAELAWVAETKRKLMA 3738
Query: 1370 DG---LRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASP 1426
G L + T QL + K +++ K S++E+ S G
Sbjct: 3739 LGPIRLEQDQTTAQLQ----VQKAFSIDIIRHKDSMDELFSHRSEIFGTCG--------- 3785
Query: 1427 KEKYSLVEAKRKKLISPESTVMLLEAQ 1453
+E+ ++++ K + LI + LL ++
Sbjct: 3786 EEQKTVLQEKTESLIQQYEAISLLNSE 3812
Score = 43.5 bits (101), Expect = 0.002
Identities = 96/522 (18%), Positives = 195/522 (37%), Gaps = 93/522 (17%)
Query: 859 KVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFG 918
++ +L + W+ + K+ R L+ +++ + Y+ + + W+ D K + L
Sbjct: 2814 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTL-- 2871
Query: 919 DSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNI 978
D + L K + +E+ +R E + A++ NS + E + +G+
Sbjct: 2872 DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGIN----- 2926
Query: 979 PIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLE 1038
++ A EL ++G + + E K K+E +
Sbjct: 2927 ------------------QNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAK 2968
Query: 1039 EELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKR------QAELDGKS 1092
+L + S+ C+ ++NL+K +A+ +A ++ L+ + DG
Sbjct: 2969 HQLEIFDALGSQACS-----NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSD 3023
Query: 1093 AKQNLDKC------YGQIKE-LNEKITRLTYEIEDEKRRRKSVEDRFDQQKN-------- 1137
A Q L + + ++K+ +N + ++E + V + F Q +
Sbjct: 3024 ASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGM 3083
Query: 1138 -----DYDQLQKARQCEKENLGWQKLESEKA-IKEKEYEIERLRVLLQEEGTRKREYENE 1191
D D LQ Q E L K+ K I+ E E R +L+EEGT +
Sbjct: 3084 GAIGRDTDSLQS--QIEDVRLFLNKIHVLKLDIEASEAE---CRHMLEEEGTL------D 3132
Query: 1192 LAKASNRIQESKNQCTQVVQ----ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE 1247
L ++ QC ++ + +E L + + +E +L+ L D A+ +
Sbjct: 3133 LLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQ 3192
Query: 1248 TRVKQRLECEKQQIQ--------------------NDLNQWKTQYSRKEEAIRKIESERE 1287
V +E QQ+ N L Q Q + K+ ++ +E + E
Sbjct: 3193 WVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME 3252
Query: 1288 KSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQL 1329
+ N+L ++ + A+++ C K +D+ S L
Sbjct: 3253 EINARWNTLNKKVAQRIAQLQEALLHC-GKFQDALEPLLSWL 3293
Score = 42.0 bits (97), Expect = 0.007
Identities = 171/973 (17%), Positives = 350/973 (35%), Gaps = 175/973 (17%)
Query: 574 EDYMKTIADLELH---YQEFIRNSQGS-----EMFGDDDKRKIQSQFTDAQKHYQTLVIQ 625
+ Y + D EL Y+ F+ + Q S M D I +F D + Y LV
Sbjct: 1341 QQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDA--ITQEFMDLRTRYTALVTL 1398
Query: 626 LPGYPQHQTVTTTEITHHGTCQDVNHNKVIE---------------TNRENDKQETWMLM 670
+ ++ + + + + +E T + ET
Sbjct: 1399 TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKEST 1458
Query: 671 ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDML 730
+++K + + +T K +++ + I + + K + + + I+E LN L
Sbjct: 1459 DIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAY 1518
Query: 731 ANF--RGSEKYCYLQNEVFGLFQK--LENINGVTDGYLNSLCTVRALLQAILQTEDMLKV 786
+ + + LQ+++ ++ L+ L LC+ + Q E L
Sbjct: 1519 HDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSW------VGQAERALAG 1572
Query: 787 YEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQY 846
++ R T++ DL ++ + LK +++D+ + + AT+ +++ + Q
Sbjct: 1573 HQGRTTQQ-----DLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFME-----ENQT 1622
Query: 847 PLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAK 906
L +L EK+ Q ++++ + ++ +LE+ + K L + K
Sbjct: 1623 KLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENK 1682
Query: 907 RRQDSLESMKFGDSNTVMRFLN-----EQKNLHSEISGKRDKSEEVQKIAELCANSIKDY 961
++ D+L ++ + L EQ + S G D ++ + + K
Sbjct: 1683 KKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQC 1742
Query: 962 ELQLASYTSGLETLLNIPIKRTMIQS------------PSGVILQEAADVHARYIELLTR 1009
E+ A + L N + Q+ ++ Q+ ++ +Y L +
Sbjct: 1743 EMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQ 1802
Query: 1010 SGDYYRFLS----EMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKY 1065
S + + E+ K L+D K + +E E+EL EN +K + L
Sbjct: 1803 SEAELKQVQTLQDELQKFLQDHKEFESWLERSEKEL--------ENMHKGGSSPETLPSL 1854
Query: 1066 QAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRR 1125
F + S + R + G+ +++ + + KE +E + +++D R
Sbjct: 1855 LKRQGSFSEDVISHKGDLRFVTISGQKVL-DMENSFKEGKEPSEIGNLVKDKLKDATERY 1913
Query: 1126 KSVEDR--------------FDQQKNDYDQLQKARQ-CE------------------KEN 1152
++ + + Q +N D LQ Q CE +E
Sbjct: 1914 TALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQ 1973
Query: 1153 LGWQKLESEKAIKEKEYEIERL----RVLLQEEGTRKREYEN-----------------E 1191
L K + ++ + E + +E+L R +++ EG ++ +
Sbjct: 1974 LATTK-QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYS 2032
Query: 1192 LAKASNRIQESKNQCTQVVQERESLLVKIKVLEQD-----------------KARLQRLE 1234
LA+ S+ +Q++ Q V + ESLL I +EQ+ A +L+
Sbjct: 2033 LAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLK 2092
Query: 1235 DELNRAKSTLEAETRVKQR-LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREK 1293
++ R KS+LEA + R +E L + S++ E + + E+E S ++
Sbjct: 2093 QDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKL 2152
Query: 1294 NSLRSEIERLQAEIKRIEERCRRKLEDSTRETQ---------SQLETERSRYQREIDKLR 1344
E L ++++ E R L + Q +L E Q +D L
Sbjct: 2153 LPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL- 2211
Query: 1345 QRPYGSHRETQ-TECEWTVDTSKLV--FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKS 1401
H T+ + C + +D + LRK T +Q T+ + K S
Sbjct: 2212 -----EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQ---------KTVKEREKDASS 2257
Query: 1402 VEEVASEIQPFLR 1414
+E E + +R
Sbjct: 2258 CQEQLDEFRKLVR 2270
Score = 39.7 bits (91), Expect = 0.034
Identities = 28/68 (41%), Positives = 36/68 (52%), Gaps = 4/68 (5%)
Query: 2208 SVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGS----FDATGNSSYSYSY 2263
S SS + + A +S SR GSR+GSR+GSR+ SRRGS FD S
Sbjct: 5330 SNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDT 5389
Query: 2264 SFSSSSIG 2271
S SS++ G
Sbjct: 5390 SESSAAGG 5397
Score = 32.3 bits (72), Expect = 5.4
Identities = 34/168 (20%), Positives = 70/168 (41%), Gaps = 14/168 (8%)
Query: 774 LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
LQA++ D L E +L E++ V DLD V K + +L + + +K +
Sbjct: 4712 LQALV---DWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLK---R 4765
Query: 834 KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
+++ + D ++ +L+ RW + K + LE+ +KQ +RD
Sbjct: 4766 SGRELIENSRD-------DTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRD 4818
Query: 894 NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKR 941
+WL +A++ ++ D+ + ++ K ++ KR
Sbjct: 4819 TVHMLLEWLSEAEQTLRFRGALP-DDTEALQSLIDTHKEFMKKVEEKR 4865
>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
Length = 1369
Score = 460 bits (1183), Expect = e-129
Identities = 262/862 (30%), Positives = 475/862 (55%), Gaps = 57/862 (6%)
Query: 78 CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
C + L +A+ ++Q +++ G R+ E++ +A+ + +L + ++ ++ P
Sbjct: 541 CEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 600
Query: 136 DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
+ +R+ +L E++ A L ++ P + A + Q ++ T
Sbjct: 601 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 657
Query: 188 TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
+ L W+ + + +D WGVDL SVE + SHRG+H SI +++ ++++ ++D + S
Sbjct: 658 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSP 717
Query: 247 --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
+ +L+ +Y LL +S R+ L L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 718 ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 777
Query: 299 SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
SD+NTN+ K+E++S M +LE+KEK++ +L+ D+L+ HPA +E++ LQTQW
Sbjct: 778 SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 837
Query: 359 SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
SW+LQ+ CI+ HLKENAAYFQFF + + E L+ LQ+++R+K CD++ + L + +
Sbjct: 838 SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLL 897
Query: 419 KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
++ + E+E++ EYK + L ++K +VQLKPR+P + + L A+CDYKQ + VHK
Sbjct: 898 QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 957
Query: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
GDEC L + S W V G + VPSV ++PPPN + ++E ++A++ LW+
Sbjct: 958 GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWH 1017
Query: 539 QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
QL+++MKSL++W D++ IR+ ++A +T++ E+ + + LELHYQ F+R+SQ +
Sbjct: 1018 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 1077
Query: 599 MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
FG +D+ + ++ HYQ L+ L Q ++ CQ
Sbjct: 1078 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 1117
Query: 659 RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
+ EL+ IR Q+E CE R + LPL D+ + +I E + Q +
Sbjct: 1118 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1167
Query: 716 --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
+ +A + + + +LA S L++E+ KLE + ++ YL L T+ +
Sbjct: 1168 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1227
Query: 774 LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
++ E++L+ +E +L E + V L ++EA + LKK++ ++ ++ EL+
Sbjct: 1228 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1287
Query: 834 KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
AQ++ + Q++ D+++ ++ E+V QL +RWQ + Q D R +LE+ +QLR YR+
Sbjct: 1288 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1347
Query: 894 NYQAFCKWLYDAKRRQDSLESM 915
+ WL DA+RRQ+ +++M
Sbjct: 1348 SADPLGAWLQDARRRQEQIQAM 1369
Score = 34.7 bits (78), Expect = 1.1
Identities = 66/341 (19%), Positives = 133/341 (39%), Gaps = 51/341 (14%)
Query: 867 WQRIDKQIDF-RLWDL--------EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917
WQ + + + R W L E+Q + L + +YQAF + DS ++ F
Sbjct: 1029 WQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLR---------DSQDAGGF 1079
Query: 918 GDSNTVM--RFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETL 975
G + +M R + + ++ ++ + + + C + +KD LQL + +
Sbjct: 1080 GPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR 1139
Query: 976 LNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIE 1035
L +P+ + P+ Q A+ E+ R +E K L L +
Sbjct: 1140 LRLPLDK----EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA-LPEPSPAAP 1194
Query: 1036 VLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQ 1095
L EL L L++ ++ + + KL ++ + R + A++
Sbjct: 1195 TLRSELELTLG--------------KLEQVRSLSAIYLEKLKTISLVIRGTQ----GAEE 1236
Query: 1096 NLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQL-------QKARQC 1148
L Q+KE + + E+E K K + + + Q+ +D L Q+ +
Sbjct: 1237 VLRAHEEQLKEA-QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1295
Query: 1149 EKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYE 1189
++ G + +E E+ + +ER + +L + R+RE E
Sbjct: 1296 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1336
>gi|207452735 epiplakin 1 [Homo sapiens]
Length = 5090
Score = 382 bits (981), Expect = e-105
Identities = 283/872 (32%), Positives = 439/872 (50%), Gaps = 91/872 (10%)
Query: 1365 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGS 1418
++ V DGL +L E Q+ +D L + SVE+ V E+ L A
Sbjct: 1263 AQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAER 1322
Query: 1419 IAGASASP--KEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 1476
A P + SL +A K L+ + LL+ Q ATGG++DP L +A
Sbjct: 1323 AAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRL 1382
Query: 1477 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 1536
L+D Q + A +K F DP + V+ + ++ + D ETG+ LL + V
Sbjct: 1383 GLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEV 1442
Query: 1537 DPVNSVFL-----PKDVALARGLIDR--DLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKE 1589
D +V L P +G DL S D ++ V + + ++
Sbjct: 1443 DDHTAVALRAMKVPVSTGRFKGCSVSLWDLLLSEYVGADKRRELVALCRSGRAAALR--- 1499
Query: 1590 RCRIEPHTGLLLLSVQKRSM--SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEV 1647
++ L+ + +++ + +F+G+R+ V+ +L + ++ T++EL G + EV
Sbjct: 1500 --QVVSAVTALVEAAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEV 1557
Query: 1648 GER--IKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDP 1705
E +K L+G + IAG+ + T++++ I EA++ ++RPGTAL LLEAQAATGFI+DP
Sbjct: 1558 AEMDSVKRSLEGGNFIAGVLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDP 1617
Query: 1706 VSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHG 1765
N +L VEEA+K G+ G E KLLSAERAVTGY DP TG ISLFQAM K+LI + HG
Sbjct: 1618 AENRKLTVEEAFKAGMFGKETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHG 1677
Query: 1766 IRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENL 1825
IRLLEAQIATGGIIDP SHR+PVD+AY+ GYF+EE++ IL+DPSDDTKGFFDPNT ENL
Sbjct: 1678 IRLLEAQIATGGIIDPVHSHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENL 1737
Query: 1826 TYLQLKERCIKDEETGLCLLPLKEKKKQ---VQTSQKNTLRKRRVVIVDPETNKEMSVQE 1882
TYLQL ERC++D ETGL LL + +K + + + ++ L+ R +M V
Sbjct: 1738 TYLQLLERCVEDPETGLYLLQIIKKGENYVYINEATRHVLQSR---------TAKMRVGR 1788
Query: 1883 AYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDR 1942
+ ++ + W+ + S+ DRK R
Sbjct: 1789 -FADQVVSF------------WDLL-------SSPYFTEDRK-----------------R 1811
Query: 1943 KFFDQYRSGSLSLTQFADMISL--------KNGVGTSSSMGSGVSDDVFSSSRHESVSKI 1994
+ +Y + S L + ++I+ G+ ++ G + D+F+S V
Sbjct: 1812 ELIQEYGAQSGGLEKLLEIITTTIEETETQNQGIKVAAIRGEVTAADLFNS----RVIDQ 1867
Query: 1995 STISSVRNLTIRSSSFSDT------LEESSPIAAIFDTENLEKISITEGIERGIVDSITG 2048
T+ ++R + S LE S IA + E +S+ E + ++ +
Sbjct: 1868 KTLHTLRVGRTGGQALSTLECVKPYLEGSDCIAGVTVPSTREVMSLHEASRKELIPAAFA 1927
Query: 2049 QRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKM 2108
LLEAQA TG ++ P T QKLS+ +AV G++++++ RL A++A G+ +
Sbjct: 1928 TWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDTI 1987
Query: 2109 SAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDT 2168
+A++++ + R LE Q TGG++DP+ H R+ E A R+G + + D
Sbjct: 1988 PLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQ 2047
Query: 2169 SSYAKILTCPKTKLKISYKDAINRSMVEDITG 2200
K P T+ K+SY++ R ++ TG
Sbjct: 2048 KHMRKRFVDPNTQEKVSYRELQERCRPQEDTG 2079
Score = 372 bits (955), Expect = e-102
Identities = 287/963 (29%), Positives = 449/963 (46%), Gaps = 149/963 (15%)
Query: 1335 RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDK 1394
RY++ L Q ETQ + + ++ LR +VT QL E +ID+ LD+
Sbjct: 853 RYRQREVTLGQVAKLLEAETQRQAD-------IMLPALRSRVTVHQLLEAGIIDQQLLDQ 905
Query: 1395 LLKGKKSVEEVA--SEIQPFLRGAGSIAGASASPK-EKYSLVEAKRKKLISPESTVMLLE 1451
+L G S E + ++ +L G G++ G P ++ SL +A R+KL+ P + LLE
Sbjct: 906 VLAGTISPEALLLMDGVRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVALALLE 965
Query: 1452 AQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEA 1511
AQAATG I+DPH E L+VD A+ R ++ + ++ AE AI GF DPFSGK VSV +A
Sbjct: 966 AQAATGTIMDPHSPESLSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQVSVFQA 1025
Query: 1512 IKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQK 1571
+KK LI E RLLEAQ+A+GG++DP + LP VA+ RG +D+++ +L+ S +
Sbjct: 1026 MKKGLIPWEQAARLLEAQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETALS---SSSE 1082
Query: 1572 NFVDPVTKKKVSYVQLKERCRIEPHTGLLLL-------------SVQKRSMSFQGIRQPV 1618
F P + + SY QL E C + +GL LL VQ+ + G +
Sbjct: 1083 TFPTPDGQGRTSYAQLLEECPRDETSGLHLLPLPESAPALPTEEQVQRSLQAVPGAKDGT 1142
Query: 1619 TVTELVDSGIL----RPSTVNELESGQISYDEVGERIKDFLQGSSCI------------- 1661
++ +L+ S R + +++ G+ + ++ ++ ++Q + +
Sbjct: 1143 SLWDLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQARVMVPGPRGE 1202
Query: 1662 --------AGIYNETTKQKL--------------------------------------GI 1675
AGI + T + L I
Sbjct: 1203 VPAVWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSGAKASI 1262
Query: 1676 YEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAER 1735
+A++ GL+ G LLEAQ A+GF+VDP++N RL VE+A K GLVG E E+L AER
Sbjct: 1263 AQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAER 1322
Query: 1736 AVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKR 1795
A GY DP + +SL+QAM K L+ + G+ LL+ Q+ATGG++DP LP A +
Sbjct: 1323 AAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRL 1382
Query: 1796 GYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL-KEKKKQV 1854
G + + S++L+ D K FFDP+ + +TY QL+ERC+ D ETGL LLPL + +V
Sbjct: 1383 GLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEV 1442
Query: 1855 QTSQKNTLRKRRV-VIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSD 1913
LR +V V +S+ + + + +EL C
Sbjct: 1443 DDHTAVALRAMKVPVSTGRFKGCSVSLWDLLLSEYVGADKRRELVAL-CRSGRAAALRQV 1501
Query: 1914 GSTRVVLVD-----------RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMI 1962
S LV+ R Q +D L+ RK D+ G+ ++ + A+M
Sbjct: 1502 VSAVTALVEAAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEMD 1561
Query: 1963 SLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2022
S+K +LE + IA
Sbjct: 1562 SVKR----------------------------------------------SLEGGNFIAG 1575
Query: 2023 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2082
+ E++SI E + R I+ T LLEAQA TG II P +KL++++A G+
Sbjct: 1576 VLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFKAGMFG 1635
Query: 2083 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2142
++ +L A++A G+ +++S +A+++ + E G R LE Q TGG++DP
Sbjct: 1636 KETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVH 1695
Query: 2143 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2202
R+ + A R G+ D + L D S K P T ++Y + R + + TGL
Sbjct: 1696 SHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLY 1755
Query: 2203 LLE 2205
LL+
Sbjct: 1756 LLQ 1758
Score = 345 bits (885), Expect = 3e-94
Identities = 253/814 (31%), Positives = 406/814 (49%), Gaps = 68/814 (8%)
Query: 1416 AGSIAGASASPK-EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAI 1474
A SIAG + S+ A + L+ LLEAQAATGG++D R + L V A+
Sbjct: 40 ARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKAL 99
Query: 1475 ARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGG 1534
+ L+ + ++++ AAE+A TG+ DP+ G+ +++ +AI K ++DR G LE Q+A+GG
Sbjct: 100 QQGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATGG 159
Query: 1535 VVDPVNSVFLPKDVALARGLIDRDLYRSLND--PRDSQKNFVDPVTKKKVSYVQLKERCR 1592
+VDP V + + A +GL+DR+ + L++ P F++P T ++++Y QL ERC
Sbjct: 160 LVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQLLERCV 219
Query: 1593 IEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER-- 1650
P +GL LL ++ ++F+ + V+ EL++ GIL V L G+++ +V R
Sbjct: 220 RAPGSGLALLPLK---ITFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAE 276
Query: 1651 IKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLR 1710
++ +L+G+ +AG+ K ++A L+ GTAL LLEAQAAT +VDP++ R
Sbjct: 277 VRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQR 336
Query: 1711 LPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLE 1770
L V+EA + GLV E E+LL AE+AVTG++DP +G+ I LFQAM K L+++ +RLL+
Sbjct: 337 LWVDEAVRAGLVSPELHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLD 396
Query: 1771 AQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQL 1830
AQ+ATGG++ P RLP++ A + G +E+ LS G F T L Y QL
Sbjct: 397 AQLATGGLVCPARRLRLPLEAALRCGCLDEDTQRQLSQ-----AGSFSDGTHGGLRYEQL 451
Query: 1831 KERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLID 1890
C+ D ETGL LPL + + ++ S ++A
Sbjct: 452 LALCVTDPETGLAFLPLSGGPRGGEPQGPPFIK--------------YSTRQALSTATAT 497
Query: 1891 YETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRS 1950
K WE + R +L QY+
Sbjct: 498 VSVGKFRGRPVSLWELLFSEAISSEQRAMLA------------------------QQYQE 533
Query: 1951 GSLSLTQFADMIS--LKNGVGTSSSMGSGVSD----------DVFSSSRHESVSK-ISTI 1997
G+LS+ + A +S L+ T+ SG+ D ++ +E + +T
Sbjct: 534 GTLSVEKLAAELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLEHGQATA 593
Query: 1998 SSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQAC 2057
V +L +S L+ + IA + + E++SI E +G++ T LLEAQA
Sbjct: 594 KDVGSL----ASAQRYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQAA 649
Query: 2058 TGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEK 2117
TG II P + S+++A+ VI D+ +L A++A G+ +++S +A+++
Sbjct: 650 TGFIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQKG 709
Query: 2118 WLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTC 2177
+ E G R LE Q TGG++DP R+ + A R+G+ D L D S K
Sbjct: 710 LIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGFFD 769
Query: 2178 PKTKLKISYKDAINRSMVEDITGLRLLEAASVSS 2211
P T ++Y + R + + TGL LL +S S
Sbjct: 770 PNTHENLTYLQLLERCVRDPETGLYLLPLSSTQS 803
Score = 339 bits (870), Expect = 2e-92
Identities = 286/963 (29%), Positives = 445/963 (46%), Gaps = 159/963 (16%)
Query: 1366 KLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGAS 1423
K+ F + V+A +L E ++D+ + L +G+ + +V++ E++ +L G GS+AG
Sbjct: 232 KITFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAEVRRYLEGTGSVAGVV 291
Query: 1424 ASPK-EKYSLVEAKRKKLISPESTVMLLEAQAAT-------------------GGIIDPH 1463
P+ K S +A + L+ + + LLEAQAAT G++ P
Sbjct: 292 LLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVSPE 351
Query: 1464 RNEKLTVDS-------------------AIARDLIDFDDRQQIYAAEKAITGFDDPFSGK 1504
+E+L V A+ + L+D ++ A+ A G P
Sbjct: 352 LHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQLATGGLVCPARRL 411
Query: 1505 TVSVSEAIKKNLIDRETGMRLLEAQIASGG--------------VVDPVNSV-FLPKDVA 1549
+ + A++ +D +T +L +A S G V DP + FLP
Sbjct: 412 RLPLEAALRCGCLDEDTQRQLSQAGSFSDGTHGGLRYEQLLALCVTDPETGLAFLPLSGG 471
Query: 1550 LARG---------LIDRDLYRSLNDPRDSQKNFVDPVTKKKVSY---VQLKERCRIEPHT 1597
G R + K PV+ ++ + + ++R +
Sbjct: 472 PRGGEPQGPPFIKYSTRQALSTATATVSVGKFRGRPVSLWELLFSEAISSEQRAMLAQQY 531
Query: 1598 GLLLLSVQKRS---------------MSFQGIRQPVTVTELVDSGILRPSTVNELESGQI 1642
LSV+K + ++F G+R VT EL+ + I+ LE GQ
Sbjct: 532 QEGTLSVEKLAAELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLEHGQA 591
Query: 1643 SYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATG 1700
+ +VG + +LQG+ CIAG+ ++++L IYEA GL+RPGTAL LLEAQAATG
Sbjct: 592 TAKDVGSLASAQRYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQAATG 651
Query: 1701 FIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELI 1760
FI+DP +N VEEA + ++G + KLLSAERAVTGY DP TG ISLFQAM K LI
Sbjct: 652 FIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQKGLI 711
Query: 1761 EKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPN 1820
+ HGIRLLEAQIATGG+IDP SHR+PVD+AY+RGYF++ L+ IL DPSDDTKGFFDPN
Sbjct: 712 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGFFDPN 771
Query: 1821 TEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSV 1880
T ENLTYLQL ERC++D ETGL LLPL + + S + ++ V
Sbjct: 772 THENLTYLQLLERCVRDPETGLYLLPLSSTQSPLVDSATQQAFQNLLLSV---KYGRFQG 828
Query: 1881 QEAYKKGLIDYETFKELCEQEC----EWEEITITGSDGSTRVVLVDRKTGSQYDI----- 1931
Q LI+ E F E ++ E+T+ L++ +T Q DI
Sbjct: 829 QRVSAWELINSEYFSEGRRRQLLRRYRQREVTL-----GQVAKLLEAETQRQADIMLPAL 883
Query: 1932 ------QDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLK------NGVGTSSSMGSGVS 1979
++ G++D++ DQ +G++S M ++ VG + SG
Sbjct: 884 RSRVTVHQLLEAGIIDQQLLDQVLAGTISPEALLLMDGVRRYLCGLGAVGGVRLLPSGQR 943
Query: 1980 DDVFSSSRHE------------------------SVSKISTISSVRNLTIRSSSFSDTLE 2015
++ + R + S +S +VR + +
Sbjct: 944 LSLYQAMRQKLLGPRVALALLEAQAATGTIMDPHSPESLSVDEAVRRGVVGPELYGRLKR 1003
Query: 2016 ESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDA 2075
IA D + +++S+ + +++G++ RLLEAQ TGGII PT+ L + A
Sbjct: 1004 AEGAIAGFRDPFSGKQVSVFQAMKKGLIPWEQAARLLEAQVATGGIIDPTSHHHLPMPVA 1063
Query: 2076 VSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTG 2135
+ +G +DQ+M T L + + F G+ + S A+ ++E +G L
Sbjct: 1064 IQRGYVDQEMETALSSSSET---FPTPDGQGRTSYAQLLEECPRDETSGLHLLPL----- 1115
Query: 2136 GLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMV 2195
PE + TEE +++ +A +D +S +L+ + + R ++
Sbjct: 1116 ----PESAPALPTEEQVQRSL---QAVPGAKDGTSLWDLLS------SCHFTEEQRRGLL 1162
Query: 2196 EDI 2198
ED+
Sbjct: 1163 EDV 1165
Score = 339 bits (869), Expect = 2e-92
Identities = 270/941 (28%), Positives = 430/941 (45%), Gaps = 137/941 (14%)
Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGASAS- 1425
F GLRK+V+A L+ QLI + TLD+L +G +V+EVA ++ L G IAG
Sbjct: 1521 FRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEMDSVKRSLEGGNFIAGVLIQG 1580
Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDS------------- 1472
+E+ S+ EA R+ ++ P + ++LLEAQAATG IIDP N KLTV+
Sbjct: 1581 TQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFKAGMFGKETYV 1640
Query: 1473 -------------------------AIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVS 1507
A+ +DLI + ++ A+ A G DP V
Sbjct: 1641 KLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVHSHRVP 1700
Query: 1508 VSEAIK-------------------KNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDV 1548
V A + K D T L Q+ V DP ++L + +
Sbjct: 1701 VDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLLQII 1760
Query: 1549 -----------ALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCR----- 1592
A L R + D +F D ++ + + +E +
Sbjct: 1761 KKGENYVYINEATRHVLQSRTAKMRVGRFADQVVSFWDLLSSPYFTEDRKRELIQEYGAQ 1820
Query: 1593 ---IEPHTGLLLLSVQKRSMSFQGI-----RQPVTVTELVDSGILRPSTVNELESGQISY 1644
+E ++ ++++ QGI R VT +L +S ++ T++ L G+
Sbjct: 1821 SGGLEKLLEIITTTIEETETQNQGIKVAAIRGEVTAADLFNSRVIDQKTLHTLRVGRTGG 1880
Query: 1645 DEVG--ERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFI 1702
+ E +K +L+GS CIAG+ +T++ + ++EA + L+ A LLEAQAATGF+
Sbjct: 1881 QALSTLECVKPYLEGSDCIAGVTVPSTREVMSLHEASRKELIPAAFATWLLEAQAATGFL 1940
Query: 1703 VDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEK 1762
+DP + +L V+EA GLV E +E+LL AERA TGY DP TG+ I LFQAM K+LIEK
Sbjct: 1941 LDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDTIPLFQAMQKQLIEK 2000
Query: 1763 GHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTE 1822
+RLLE Q+ATGG+IDP+ HRLP++ AY+RG ++++ ++SD K F DPNT+
Sbjct: 2001 AEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQKHMRKRFVDPNTQ 2060
Query: 1823 ENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQE 1882
E ++Y +L+ERC E+TG L P+ + + + +D ET + +
Sbjct: 2061 EKVSYRELQERCRPQEDTGWVLFPVNKAARDSEH-------------IDDETRRAL---- 2103
Query: 1883 AYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDR 1942
E E EIT+ G + S+Y ++ K + R
Sbjct: 2104 ------------------EAEQVEITVGRFRGQKPTLWA--LLNSEYVTEE--KKLQLVR 2141
Query: 1943 KFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSS-------RHESVSKIS 1995
+ R ++ Q + K G+ + +S E + +
Sbjct: 2142 MYRTHTRRALQTVAQLILELIEKQETSNKHLWFQGIRRQITASELLSSAIITEEMLQDLE 2201
Query: 1996 TISSVRNLTIRSSSFSDTLEESSPIAAIF-----DTENLEKISITEGIERGIVDSITGQR 2050
T S + LE +S IA + EK+SI + + +G++ T
Sbjct: 2202 TGRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALV 2261
Query: 2051 LLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSA 2110
LLEAQA TG +I P +LS+++ V GV+ ++ +L A++A G+ +++S
Sbjct: 2262 LLEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEIQEKLLSAERAVTGYTDPYTGQQISL 2321
Query: 2111 AEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSS 2170
+A+++ + E G R LE Q TGG++DP R+ + A R+G+ D + L D S
Sbjct: 2322 FQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSD 2381
Query: 2171 YAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSS 2211
K P T ++Y + R + + TGL +L+ A S
Sbjct: 2382 DTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGRGS 2422
Score = 330 bits (847), Expect = 7e-90
Identities = 215/519 (41%), Positives = 294/519 (56%), Gaps = 34/519 (6%)
Query: 1378 AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASPK--EK 1429
A L E Q LD + K SV+E V E++ L A A P +
Sbjct: 1927 ATWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDT 1986
Query: 1430 YSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYA 1489
L +A +K+LI + LLE Q ATGG+IDP + +L +++A R + D I
Sbjct: 1987 IPLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISD 2046
Query: 1490 AEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIA---SGGVVDPVNSVFLPK 1546
+ F DP + + VS E ++ +TG L A S + D +
Sbjct: 2047 QKHMRKRFVDPNTQEKVSYRELQERCRPQEDTGWVLFPVNKAARDSEHIDDETRRALEAE 2106
Query: 1547 DVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKE---RCRIEPHTGLLLLS 1603
V + G +R + N +KK+ V++ R ++ L+L
Sbjct: 2107 QVEITVGR-----FRGQKPTLWALLNSEYVTEEKKLQLVRMYRTHTRRALQTVAQLILEL 2161
Query: 1604 VQKRSMS-----FQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGE--RIKDFLQ 1656
++K+ S FQGIR+ +T +EL+ S I+ + +LE+G+ + E+ E R+K +L+
Sbjct: 2162 IEKQETSNKHLWFQGIRRQITASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRYLE 2221
Query: 1657 GSSCIAGIYNETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRL 1711
G+SCIAG+ Q K+ IY+AM G++RPGTAL LLEAQAATGF++DPV NLRL
Sbjct: 2222 GTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRL 2281
Query: 1712 PVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEA 1771
VEE G+VG E +EKLLSAERAVTGY DP TG ISLFQAM K+LI + HGIRLLEA
Sbjct: 2282 SVEEPVPAGVVGSEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEA 2341
Query: 1772 QIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLK 1831
QIATGG+IDP SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTY+QL
Sbjct: 2342 QIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLL 2401
Query: 1832 ERCIKDEETGLCLLPLKEKKK---QVQTSQKNTLRKRRV 1867
RC+ D +TGL +L L + Q+ + LR RV
Sbjct: 2402 RRCVPDPDTGLYMLQLAGRGSAVHQLSEELRCALRDARV 2440
Score = 308 bits (788), Expect = 5e-83
Identities = 271/950 (28%), Positives = 431/950 (45%), Gaps = 151/950 (15%)
Query: 1353 ETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQ 1410
E E T+++ F GLR VT +L + ++ID+ ++L G+ + ++V S Q
Sbjct: 544 ELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLEHGQATAKDVGSLASAQ 603
Query: 1411 PFLRGAGSIAGASA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLT 1469
+L+G G IAG +E+ S+ EA+ K L+ P + ++LLEAQAATG IIDP N+ +
Sbjct: 604 RYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQAATGFIIDPKANKGHS 663
Query: 1470 VDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQ 1529
V+ A+ +I D ++ +AE+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQ
Sbjct: 664 VEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQKGLIVREHGIRLLEAQ 723
Query: 1530 IASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKE 1589
IA+GGV+DPV+S +P DVA RG D+ L L DP D K F DP T + ++Y+QL E
Sbjct: 724 IATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGFFDPNTHENLTYLQLLE 783
Query: 1590 RCRIEPHTGLLLLSVQK---------RSMSFQGI----------RQPVTVTELVDS---- 1626
RC +P TGL LL + +FQ + Q V+ EL++S
Sbjct: 784 RCVRDPETGLYLLPLSSTQSPLVDSATQQAFQNLLLSVKYGRFQGQRVSAWELINSEYFS 843
Query: 1627 -----GILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKL---GIYEA 1678
+LR E+ GQ++ E + Q + + + T +L GI +
Sbjct: 844 EGRRRQLLRRYRQREVTLGQVAKLLEAETQR---QADIMLPALRSRVTVHQLLEAGIIDQ 900
Query: 1679 MKIGLVRPGT----ALELLE-------AQAATGFIVDPVSNLRLPVEEAYKRGLVG---- 1723
+ V GT AL L++ A G + S RL + +A ++ L+G
Sbjct: 901 QLLDQVLAGTISPEALLLMDGVRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVA 960
Query: 1724 ----------------------------------IEFKEKLLSAERAVTGYNDPETGNII 1749
E +L AE A+ G+ DP +G +
Sbjct: 961 LALLEAQAATGTIMDPHSPESLSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQV 1020
Query: 1750 SLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDP 1809
S+FQAM K LI RLLEAQ+ATGGIIDP H LP+ +A +RGY ++E+ LS
Sbjct: 1021 SVFQAMKKGLIPWEQAARLLEAQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETALSSS 1080
Query: 1810 SDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVI 1869
S+ F P+ + +Y QL E C +DE +GL LLPL E + T ++ + V
Sbjct: 1081 SET---FPTPDGQGRTSYAQLLEECPRDETSGLHLLPLPESAPALPTEEQVQRSLQAVPG 1137
Query: 1870 VDPETN-----KEMSVQEAYKKGLID-----YETFKELCEQECEWEEITITGSDGSTRVV 1919
T+ E ++GL++ T +L W + T + V
Sbjct: 1138 AKDGTSLWDLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQAR---V 1194
Query: 1920 LVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVS 1979
+V G + +D G++ ++ + G+ S Q A+ ++K + G+G
Sbjct: 1195 MVPGPRGEVPAVW-LLDAGIITQETLEALAQGTQSPAQVAEQPAVK-----ACLWGTGCV 1248
Query: 1980 DDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIE 2039
V S +K S +VR+ + + LE + D N +++S+ + ++
Sbjct: 1249 AGVL---LQPSGAKASIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVK 1305
Query: 2040 RGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGF 2099
G+V ++L +A+ G P + LSL A+ +G++
Sbjct: 1306 VGLVGRELSEQLGQAERAAAGYPDPYSRASLSLWQAMEKGLV------------------ 1347
Query: 2100 EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG-RISTEEAIRKGFID 2158
P G L+ Q TGG+VDP VHG + A R G +D
Sbjct: 1348 --------------------PQNEGLPLLQVQLATGGVVDP-VHGVHLPQAAACRLGLLD 1386
Query: 2159 GRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAAS 2208
+ +Q L K P + +++Y+ R + + TGL LL S
Sbjct: 1387 TQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPS 1436
Score = 296 bits (758), Expect = 2e-79
Identities = 157/269 (58%), Positives = 197/269 (73%), Gaps = 10/269 (3%)
Query: 1609 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYN 1666
+SF+G+R+ V+ +EL SGIL P T+ +L G + EV E +K +L+G+SCIAG+
Sbjct: 2706 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 2765
Query: 1667 ETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGL 1721
Q K+ IY+AM G++RPGTAL LLEAQAATGF++DPV NLRL VEEA G+
Sbjct: 2766 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 2825
Query: 1722 VGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDP 1781
VG E +EKLLSAERAVTGY DP TG ISLFQAM K+LI + HGIRLLEAQIATGG+IDP
Sbjct: 2826 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 2885
Query: 1782 KESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETG 1841
SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTY+QL RC+ D +TG
Sbjct: 2886 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTG 2945
Query: 1842 LCLLPLKEKKK---QVQTSQKNTLRKRRV 1867
L +L L + Q+ + LR RV
Sbjct: 2946 LYMLQLAGRGSAVHQLSEELRCALRDARV 2974
Score = 296 bits (758), Expect = 2e-79
Identities = 157/269 (58%), Positives = 197/269 (73%), Gaps = 10/269 (3%)
Query: 1609 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYN 1666
+SF+G+R+ V+ +EL SGIL P T+ +L G + EV E +K +L+G+SCIAG+
Sbjct: 3240 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 3299
Query: 1667 ETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGL 1721
Q K+ IY+AM G++RPGTAL LLEAQAATGF++DPV NLRL VEEA G+
Sbjct: 3300 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 3359
Query: 1722 VGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDP 1781
VG E +EKLLSAERAVTGY DP TG ISLFQAM K+LI + HGIRLLEAQIATGG+IDP
Sbjct: 3360 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 3419
Query: 1782 KESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETG 1841
SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTY+QL RC+ D +TG
Sbjct: 3420 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTG 3479
Query: 1842 LCLLPLKEKKK---QVQTSQKNTLRKRRV 1867
L +L L + Q+ + LR RV
Sbjct: 3480 LYMLQLAGRGSAVHQLSEELRCALRDARV 3508
Score = 296 bits (758), Expect = 2e-79
Identities = 157/269 (58%), Positives = 197/269 (73%), Gaps = 10/269 (3%)
Query: 1609 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYN 1666
+SF+G+R+ V+ +EL SGIL P T+ +L G + EV E +K +L+G+SCIAG+
Sbjct: 3774 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 3833
Query: 1667 ETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGL 1721
Q K+ IY+AM G++RPGTAL LLEAQAATGF++DPV NLRL VEEA G+
Sbjct: 3834 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 3893
Query: 1722 VGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDP 1781
VG E +EKLLSAERAVTGY DP TG ISLFQAM K+LI + HGIRLLEAQIATGG+IDP
Sbjct: 3894 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 3953
Query: 1782 KESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETG 1841
SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTY+QL RC+ D +TG
Sbjct: 3954 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTG 4013
Query: 1842 LCLLPLKEKKK---QVQTSQKNTLRKRRV 1867
L +L L + Q+ + LR RV
Sbjct: 4014 LYMLQLAGRGSAVHQLSEELRCALRDARV 4042
Score = 296 bits (758), Expect = 2e-79
Identities = 157/269 (58%), Positives = 197/269 (73%), Gaps = 10/269 (3%)
Query: 1609 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYN 1666
+SF+G+R+ V+ +EL SGIL P T+ +L G + EV E +K +L+G+SCIAG+
Sbjct: 4308 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 4367
Query: 1667 ETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGL 1721
Q K+ IY+AM G++RPGTAL LLEAQAATGF++DPV NLRL VEEA G+
Sbjct: 4368 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 4427
Query: 1722 VGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDP 1781
VG E +EKLLSAERAVTGY DP TG ISLFQAM K+LI + HGIRLLEAQIATGG+IDP
Sbjct: 4428 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 4487
Query: 1782 KESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETG 1841
SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTY+QL RC+ D +TG
Sbjct: 4488 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTG 4547
Query: 1842 LCLLPLKEKKK---QVQTSQKNTLRKRRV 1867
L +L L + Q+ + LR RV
Sbjct: 4548 LYMLQLAGRGSAVHQLSEELRCALRDARV 4576
Score = 293 bits (750), Expect = 1e-78
Identities = 153/246 (62%), Positives = 187/246 (76%), Gaps = 7/246 (2%)
Query: 1609 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYN 1666
+SF+G+R+ V+ +EL SGIL P T+ +L G + EV E +K +L+G+SCIAG+
Sbjct: 4842 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 4901
Query: 1667 ETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGL 1721
Q K+ IY+AM G++RPGTAL LLEAQAATGF++DPV NLRL VEEA G+
Sbjct: 4902 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 4961
Query: 1722 VGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDP 1781
VG E +EKLLSAERAVTGY DP TG ISLFQAM K+LI + HGIRLLEAQIATGG+IDP
Sbjct: 4962 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 5021
Query: 1782 KESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETG 1841
SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL +R D ETG
Sbjct: 5022 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETG 5081
Query: 1842 LCLLPL 1847
L L L
Sbjct: 5082 LLFLSL 5087
Score = 229 bits (584), Expect = 2e-59
Identities = 241/958 (25%), Positives = 411/958 (42%), Gaps = 130/958 (13%)
Query: 1311 EERCRRKLED--STRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLV 1368
EE+ R LED R T QL R+ +E L Q ++++
Sbjct: 1155 EEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQ-------------------ARVM 1195
Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASE--IQPFLRGAGSIAGASASP 1426
G R +V A+ L + +I + TL+ L +G +S +VA + ++ L G G +AG P
Sbjct: 1196 VPGPRGEVPAVWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQP 1255
Query: 1427 K-EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
K S+ +A R L+ LLEAQ A+G ++DP N++L+V+ A+ L+ + +
Sbjct: 1256 SGAKASIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSE 1315
Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
Q+ AE+A G+ DP+S ++S+ +A++K L+ + G+ LL+ Q+A+GGVVDPV+ V LP
Sbjct: 1316 QLGQAERAAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLP 1375
Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
+ A GL+D + L K F DP + +V+Y QL+ERC + TGLLLL +
Sbjct: 1376 QAAACRLGLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLP 1435
Query: 1606 K---------RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGE------- 1649
+++ + ++ PV+ + S + L S + D+ E
Sbjct: 1436 SDTVLEVDDHTAVALRAMKVPVSTGRFKGCSV---SLWDLLLSEYVGADKRRELVALCRS 1492
Query: 1650 -RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSN 1708
R Q S + + +Q L +A GL + +A +L AQ + +D +S
Sbjct: 1493 GRAAALRQVVSAVTALVEAAERQPL---QATFRGLRKQVSARDLFRAQLISRKTLDELSQ 1549
Query: 1709 LRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRL 1768
V+E + V ++ L + G T +S+ +A+ + ++ G + L
Sbjct: 1550 GTTTVKEVAEMDSV-----KRSLEGGNFIAGVLIQGTQERMSIPEALRRHILRPGTALVL 1604
Query: 1769 LEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYL 1828
LEAQ ATG IIDP E+ +L V+ A+K G F +E L G+ DP T + ++
Sbjct: 1605 LEAQAATGFIIDPAENRKLTVEEAFKAGMFGKETYVKLLSAERAVTGYTDPYTGQQISLF 1664
Query: 1829 QLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGL 1888
Q ++ + E G+ LL + Q+ T I+DP + + V AY+ G
Sbjct: 1665 QAMQKDLIVREHGIRLL-----EAQIATGG----------IIDPVHSHRVPVDVAYRCGY 1709
Query: 1889 IDYETFKELCEQECEWEEITITGS-DGSTRVVLVDR---------------KTGSQYDIQ 1932
D E + L + + + + + T + L++R K G Y
Sbjct: 1710 FDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLLQIIKKGENYVYI 1769
Query: 1933 DAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVS 1992
+ + ++ Q R+ + + +FAD + S +S F+ R +
Sbjct: 1770 NEATRHVL------QSRTAKMRVGRFADQVV---------SFWDLLSSPYFTEDRKREL- 1813
Query: 1993 KISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIE-RGIVDSITGQRL 2051
++ +S LE + +T+N +GI+ I +T L
Sbjct: 1814 -------IQEYGAQSGGLEKLLEIITTTIEETETQN-------QGIKVAAIRGEVTAADL 1859
Query: 2052 LEAQACTGGIIHP-----TTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKK 2106
++ +H T GQ LS + V + D G ++
Sbjct: 1860 FNSRVIDQKTLHTLRVGRTGGQALSTLECVKPYLEGSD----------CIAGVTVPSTRE 1909
Query: 2107 KMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQ 2166
MS EA +++ +P LE Q TG L+DP ++S +EA+ G ++ +RL
Sbjct: 1910 VMSLHEASRKELIPAAFATWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLL 1969
Query: 2167 DTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAP 2224
A P T I A+ + ++E LRLLE V++ G+ P + P
Sbjct: 1970 KAERAATGYRDPATGDTIPLFQAMQKQLIEKAEALRLLE-VQVATGGVIDPQHHHRLP 2026
Score = 228 bits (581), Expect = 5e-59
Identities = 174/594 (29%), Positives = 297/594 (50%), Gaps = 37/594 (6%)
Query: 1322 TRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQL 1381
T + + +L E ++KL + + ET+T+ + +R +VTA L
Sbjct: 1806 TEDRKRELIQEYGAQSGGLEKLLEIITTTIEETETQ------NQGIKVAAIRGEVTAADL 1859
Query: 1382 YECQLIDKTTLDKLLKGKKSVEEVASE--IQPFLRGAGSIAGASA-SPKEKYSLVEAKRK 1438
+ ++ID+ TL L G+ + +++ ++P+L G+ IAG + S +E SL EA RK
Sbjct: 1860 FNSRVIDQKTLHTLRVGRTGGQALSTLECVKPYLEGSDCIAGVTVPSTREVMSLHEASRK 1919
Query: 1439 KLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFD 1498
+LI LLEAQAATG ++DP +KL+VD A+ L++ + R+++ AE+A TG+
Sbjct: 1920 ELIPAAFATWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYR 1979
Query: 1499 DPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRD 1558
DP +G T+ + +A++K LI++ +RLLE Q+A+GGV+DP + LP + A RG + +D
Sbjct: 1980 DPATGDTIPLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKD 2039
Query: 1559 LYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGI---R 1615
+Y ++D + +K FVDP T++KVSY +L+ERCR + TG +L V K + + I
Sbjct: 2040 IYALISDQKHMRKRFVDPNTQEKVSYRELQERCRPQEDTGWVLFPVNKAARDSEHIDDET 2099
Query: 1616 QPVTVTELVDSGILR-----PSTVNELESGQISYDEVGERIKDF----LQGSSCIAGIYN 1666
+ E V+ + R P+ L S ++ ++ + ++ + + +A +
Sbjct: 2100 RRALEAEQVEITVGRFRGQKPTLWALLNSEYVTEEKKLQLVRMYRTHTRRALQTVAQLIL 2159
Query: 1667 E-TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIE 1725
E KQ+ G+ R TA ELL + T ++ + R +E + V
Sbjct: 2160 ELIEKQETSNKHLWFQGIRRQITASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRY 2219
Query: 1726 FKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESH 1785
+ A V + P +S++QAM K ++ G + LLEAQ ATG +IDP +
Sbjct: 2220 LEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNL 2279
Query: 1786 RLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLL 1845
RL V+ G E+ E L G+ DP T + ++ Q ++ + E G+ LL
Sbjct: 2280 RLSVEEPVPAGVVGSEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL 2339
Query: 1846 PLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 1899
+ Q+ T ++DP + + V AY++G D E + L +
Sbjct: 2340 -----EAQIATGG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 2378
Score = 198 bits (504), Expect = 4e-50
Identities = 105/248 (42%), Positives = 167/248 (67%), Gaps = 8/248 (3%)
Query: 1365 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGA 1422
SK+ F GLR++V+A +L+ ++ TL L +G K+++EV ++ +L G IAG
Sbjct: 4840 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 4899
Query: 1423 SASPK------EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 1476
K EK S+ +A K ++ P + ++LLEAQAATG +IDP RN +L+V+ A+A
Sbjct: 4900 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 4959
Query: 1477 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 1536
++ + ++++ +AE+A+TG+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+
Sbjct: 4960 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 5019
Query: 1537 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH 1596
DPV+S +P DVA RG D ++ R L DP D K F DP T + ++Y+QL +R ++P
Sbjct: 5020 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPE 5079
Query: 1597 TGLLLLSV 1604
TGLL LS+
Sbjct: 5080 TGLLFLSL 5087
Score = 197 bits (501), Expect = 1e-49
Identities = 106/251 (42%), Positives = 166/251 (66%), Gaps = 8/251 (3%)
Query: 1365 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGA 1422
SK+ F GLR++V+A +L+ ++ TL L +G K+++EV ++ +L G IAG
Sbjct: 2704 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 2763
Query: 1423 SASPK------EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 1476
K EK S+ +A K ++ P + ++LLEAQAATG +IDP RN +L+V+ A+A
Sbjct: 2764 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 2823
Query: 1477 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 1536
++ + ++++ +AE+A+TG+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+
Sbjct: 2824 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 2883
Query: 1537 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH 1596
DPV+S +P DVA RG D ++ R L DP D K F DP T + ++YVQL RC +P
Sbjct: 2884 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD 2943
Query: 1597 TGLLLLSVQKR 1607
TGL +L + R
Sbjct: 2944 TGLYMLQLAGR 2954
Score = 197 bits (501), Expect = 1e-49
Identities = 106/251 (42%), Positives = 166/251 (66%), Gaps = 8/251 (3%)
Query: 1365 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGA 1422
SK+ F GLR++V+A +L+ ++ TL L +G K+++EV ++ +L G IAG
Sbjct: 3238 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 3297
Query: 1423 SASPK------EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 1476
K EK S+ +A K ++ P + ++LLEAQAATG +IDP RN +L+V+ A+A
Sbjct: 3298 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 3357
Query: 1477 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 1536
++ + ++++ +AE+A+TG+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+
Sbjct: 3358 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 3417
Query: 1537 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH 1596
DPV+S +P DVA RG D ++ R L DP D K F DP T + ++YVQL RC +P
Sbjct: 3418 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD 3477
Query: 1597 TGLLLLSVQKR 1607
TGL +L + R
Sbjct: 3478 TGLYMLQLAGR 3488
Score = 197 bits (501), Expect = 1e-49
Identities = 106/251 (42%), Positives = 166/251 (66%), Gaps = 8/251 (3%)
Query: 1365 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGA 1422
SK+ F GLR++V+A +L+ ++ TL L +G K+++EV ++ +L G IAG
Sbjct: 3772 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 3831
Query: 1423 SASPK------EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 1476
K EK S+ +A K ++ P + ++LLEAQAATG +IDP RN +L+V+ A+A
Sbjct: 3832 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 3891
Query: 1477 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 1536
++ + ++++ +AE+A+TG+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+
Sbjct: 3892 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 3951
Query: 1537 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH 1596
DPV+S +P DVA RG D ++ R L DP D K F DP T + ++YVQL RC +P
Sbjct: 3952 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD 4011
Query: 1597 TGLLLLSVQKR 1607
TGL +L + R
Sbjct: 4012 TGLYMLQLAGR 4022
Score = 197 bits (501), Expect = 1e-49
Identities = 106/251 (42%), Positives = 166/251 (66%), Gaps = 8/251 (3%)
Query: 1365 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGA 1422
SK+ F GLR++V+A +L+ ++ TL L +G K+++EV ++ +L G IAG
Sbjct: 4306 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 4365
Query: 1423 SASPK------EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 1476
K EK S+ +A K ++ P + ++LLEAQAATG +IDP RN +L+V+ A+A
Sbjct: 4366 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 4425
Query: 1477 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 1536
++ + ++++ +AE+A+TG+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+
Sbjct: 4426 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 4485
Query: 1537 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH 1596
DPV+S +P DVA RG D ++ R L DP D K F DP T + ++YVQL RC +P
Sbjct: 4486 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD 4545
Query: 1597 TGLLLLSVQKR 1607
TGL +L + R
Sbjct: 4546 TGLYMLQLAGR 4556
Score = 191 bits (485), Expect = 7e-48
Identities = 120/351 (34%), Positives = 198/351 (56%), Gaps = 28/351 (7%)
Query: 1285 EREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE-TQSQLETER--------SR 1335
ER + + + + + + + + I++ RR LE E T + ++ S
Sbjct: 2070 ERCRPQEDTGWVLFPVNKAARDSEHIDDETRRALEAEQVEITVGRFRGQKPTLWALLNSE 2129
Query: 1336 YQREIDKLRQ-RPYGSH--RETQTECEWTVD--------TSKLVFDGLRKKVTAMQLYEC 1384
Y E KL+ R Y +H R QT + ++ L F G+R+++TA +L
Sbjct: 2130 YVTEEKKLQLVRMYRTHTRRALQTVAQLILELIEKQETSNKHLWFQGIRRQITASELLSS 2189
Query: 1385 QLIDKTTLDKLLKGKKSVEEVASE--IQPFLRGAGSIAGASASPK------EKYSLVEAK 1436
+I + L L G+ + +E+ + ++ +L G IAG K EK S+ +A
Sbjct: 2190 AIITEEMLQDLETGRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAM 2249
Query: 1437 RKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITG 1496
K ++ P + ++LLEAQAATG +IDP RN +L+V+ + ++ + ++++ +AE+A+TG
Sbjct: 2250 WKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEIQEKLLSAERAVTG 2309
Query: 1497 FDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLID 1556
+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+DPV+S +P DVA RG D
Sbjct: 2310 YTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFD 2369
Query: 1557 RDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKR 1607
++ R L DP D K F DP T + ++YVQL RC +P TGL +L + R
Sbjct: 2370 EEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGR 2420
Score = 108 bits (270), Expect = 6e-23
Identities = 117/481 (24%), Positives = 195/481 (40%), Gaps = 44/481 (9%)
Query: 1735 RAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYK 1794
R++ G +G S++ AM + L+ G G LLEAQ ATGG++D LPV A +
Sbjct: 41 RSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQ 100
Query: 1795 RGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQV 1854
+G EL E L T G+ DP E L Q + + D G L + Q+
Sbjct: 101 QGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEV-----QL 155
Query: 1855 QTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDG 1914
T +VDP ++ + A +GL+D ET+ +L E E ++ +
Sbjct: 156 ATGG----------LVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPN- 204
Query: 1915 STRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSM 1974
++R T Q + G SG L S+ V + +
Sbjct: 205 -----TLERLTYHQLLERCVRAPG-----------SGLALLPLKITFRSMGGAVSAAELL 248
Query: 1975 GSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISI 2034
G+ D+ E +++ + +R LE + +A + K S
Sbjct: 249 EVGILDEQAVQGLREG--RLAAVDVSARAEVRRY-----LEGTGSVAGVVLLPEGHKKSF 301
Query: 2035 TEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQK 2094
+ ++ T LLEAQA T ++ P TGQ+L + +AV G++ ++ +L A++
Sbjct: 302 FQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVSPELHEQLLVAEQ 361
Query: 2095 AFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRK 2154
A G ++ +A+K+ + R L+ Q TGGLV P R+ E A+R
Sbjct: 362 AVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQLATGGLVCPARRLRLPLEAALRC 421
Query: 2155 GFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGL 2214
G +D ++L S++ T + Y+ + + + TGL L + G
Sbjct: 422 GCLDEDTQRQLSQAGSFS-----DGTHGGLRYEQLLALCVTDPETGLAFLPLSGGPRGGE 476
Query: 2215 P 2215
P
Sbjct: 477 P 477
Score = 97.1 bits (240), Expect = 2e-19
Identities = 58/182 (31%), Positives = 99/182 (54%)
Query: 2030 EKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2089
EK+SI + + +G++ T LLEAQA TG +I P +LS+++AV+ GV+ ++ +L
Sbjct: 2775 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 2834
Query: 2090 KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTE 2149
A++A G+ +++S +A+++ + E G R LE Q TGG++DP R+ +
Sbjct: 2835 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 2894
Query: 2150 EAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASV 2209
A R+G+ D + L D S K P T ++Y + R + + TGL +L+ A
Sbjct: 2895 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGR 2954
Query: 2210 SS 2211
S
Sbjct: 2955 GS 2956
Score = 97.1 bits (240), Expect = 2e-19
Identities = 58/182 (31%), Positives = 99/182 (54%)
Query: 2030 EKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2089
EK+SI + + +G++ T LLEAQA TG +I P +LS+++AV+ GV+ ++ +L
Sbjct: 3309 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 3368
Query: 2090 KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTE 2149
A++A G+ +++S +A+++ + E G R LE Q TGG++DP R+ +
Sbjct: 3369 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 3428
Query: 2150 EAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASV 2209
A R+G+ D + L D S K P T ++Y + R + + TGL +L+ A
Sbjct: 3429 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGR 3488
Query: 2210 SS 2211
S
Sbjct: 3489 GS 3490
Score = 97.1 bits (240), Expect = 2e-19
Identities = 58/182 (31%), Positives = 99/182 (54%)
Query: 2030 EKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2089
EK+SI + + +G++ T LLEAQA TG +I P +LS+++AV+ GV+ ++ +L
Sbjct: 3843 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 3902
Query: 2090 KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTE 2149
A++A G+ +++S +A+++ + E G R LE Q TGG++DP R+ +
Sbjct: 3903 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 3962
Query: 2150 EAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASV 2209
A R+G+ D + L D S K P T ++Y + R + + TGL +L+ A
Sbjct: 3963 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGR 4022
Query: 2210 SS 2211
S
Sbjct: 4023 GS 4024
Score = 97.1 bits (240), Expect = 2e-19
Identities = 58/182 (31%), Positives = 99/182 (54%)
Query: 2030 EKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2089
EK+SI + + +G++ T LLEAQA TG +I P +LS+++AV+ GV+ ++ +L
Sbjct: 4377 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 4436
Query: 2090 KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTE 2149
A++A G+ +++S +A+++ + E G R LE Q TGG++DP R+ +
Sbjct: 4437 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 4496
Query: 2150 EAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASV 2209
A R+G+ D + L D S K P T ++Y + R + + TGL +L+ A
Sbjct: 4497 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGR 4556
Query: 2210 SS 2211
S
Sbjct: 4557 GS 4558
Score = 95.1 bits (235), Expect = 7e-19
Identities = 56/175 (32%), Positives = 96/175 (54%)
Query: 2030 EKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2089
EK+SI + + +G++ T LLEAQA TG +I P +LS+++AV+ GV+ ++ +L
Sbjct: 4911 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 4970
Query: 2090 KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTE 2149
A++A G+ +++S +A+++ + E G R LE Q TGG++DP R+ +
Sbjct: 4971 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 5030
Query: 2150 EAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
A R+G+ D + L D S K P T ++Y + R+ ++ TGL L
Sbjct: 5031 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFL 5085
Score = 89.4 bits (220), Expect = 4e-17
Identities = 55/191 (28%), Positives = 100/191 (52%), Gaps = 2/191 (1%)
Query: 2016 ESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDA 2075
++ IA ++ + + S+ +E+G++ + GQ LLEAQA TGG++ GQ L + A
Sbjct: 39 QARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKA 98
Query: 2076 VSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTG 2135
+ QG++ ++ +L A++A G+ G +K++ +A+ ++ + GQ +LE Q TG
Sbjct: 99 LQQGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATG 158
Query: 2136 GLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTC--PKTKLKISYKDAINRS 2193
GLVDP ++ E A +G +D +L + L P T +++Y + R
Sbjct: 159 GLVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQLLERC 218
Query: 2194 MVEDITGLRLL 2204
+ +GL LL
Sbjct: 219 VRAPGSGLALL 229
Score = 79.7 bits (195), Expect = 3e-14
Identities = 103/426 (24%), Positives = 173/426 (40%), Gaps = 69/426 (16%)
Query: 1118 IEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVL 1177
I D+K RK D Q+K Y +LQ+ R +E+ GW KA ++ E+ + R
Sbjct: 2044 ISDQKHMRKRFVDPNTQEKVSYRELQE-RCRPQEDTGWVLFPVNKAARDSEHIDDETRRA 2102
Query: 1178 LQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDEL 1237
L+ E + E+ R Q+ +LL V E+ K +L R+
Sbjct: 2103 LEAE-------QVEITVGRFRGQK---------PTLWALLNSEYVTEEKKLQLVRM---- 2142
Query: 1238 NRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLR 1297
T ++ L+ Q I + + +T S K + I + SE +++
Sbjct: 2143 --------YRTHTRRALQTVAQLILELIEKQET--SNKHLWFQGIRRQITASELLSSAI- 2191
Query: 1298 SEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE--------IDKLRQRPYG 1349
I E + LE TQ +E +R + E + + +P
Sbjct: 2192 ------------ITEEMLQDLETGRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQPGR 2239
Query: 1350 SHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEE----- 1404
+ + + W G+ + TA+ L E Q +D + + SVEE
Sbjct: 2240 QEKMSIYQAMW---------KGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAG 2290
Query: 1405 -VASEIQPFLRGAGSIAGASASP--KEKYSLVEAKRKKLISPESTVMLLEAQAATGGIID 1461
V SEIQ L A P ++ SL +A +K LI E + LLEAQ ATGG+ID
Sbjct: 2291 VVGSEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVID 2350
Query: 1462 PHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRET 1521
P + ++ VD A R D + + + GF DP + + ++ + +++ + D +T
Sbjct: 2351 PVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDT 2410
Query: 1522 GMRLLE 1527
G+ +L+
Sbjct: 2411 GLYMLQ 2416
Score = 70.9 bits (172), Expect = 1e-11
Identities = 42/170 (24%), Positives = 82/170 (48%), Gaps = 7/170 (4%)
Query: 1611 FQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEV-------GERIKDFLQGSSCIAG 1663
++G+ +P T L+++ ++ + + ++S +E GE + L + G
Sbjct: 4920 WKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTG 4979
Query: 1664 IYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVG 1723
+ T Q++ +++AM+ L+ + LLEAQ ATG ++DPV + R+PV+ AY+RG
Sbjct: 4980 YTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFD 5039
Query: 1724 IEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQI 1773
E L G+ DP T ++ Q + + ++ G+ L +
Sbjct: 5040 EEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLSL 5089
Score = 69.7 bits (169), Expect = 3e-11
Identities = 51/171 (29%), Positives = 82/171 (47%), Gaps = 8/171 (4%)
Query: 1368 VFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAG 1421
++ G+ + TA+ L E Q +D + + SVEE V EIQ L A
Sbjct: 4919 MWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVT 4978
Query: 1422 ASASPK--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLI 1479
P ++ SL +A +K LI E + LLEAQ ATGG+IDP + ++ VD A R
Sbjct: 4979 GYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYF 5038
Query: 1480 DFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQI 1530
D + + + GF DP + + ++ + +++ +D ETG+ L +
Sbjct: 5039 DEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLSL 5089
Score = 65.9 bits (159), Expect = 4e-10
Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%)
Query: 1737 VTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG 1796
V + P +S++QAM K ++ G + LLEAQ ATG +IDP + RL V+ A G
Sbjct: 2765 VPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAG 2824
Query: 1797 YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQT 1856
E+ E L G+ DP T + ++ Q ++ + E G+ LL + Q+ T
Sbjct: 2825 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL-----EAQIAT 2879
Query: 1857 SQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 1899
++DP + + V AY++G D E + L +
Sbjct: 2880 GG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 2912
Score = 65.9 bits (159), Expect = 4e-10
Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%)
Query: 1737 VTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG 1796
V + P +S++QAM K ++ G + LLEAQ ATG +IDP + RL V+ A G
Sbjct: 3299 VPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAG 3358
Query: 1797 YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQT 1856
E+ E L G+ DP T + ++ Q ++ + E G+ LL + Q+ T
Sbjct: 3359 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL-----EAQIAT 3413
Query: 1857 SQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 1899
++DP + + V AY++G D E + L +
Sbjct: 3414 GG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 3446
Score = 65.9 bits (159), Expect = 4e-10
Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%)
Query: 1737 VTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG 1796
V + P +S++QAM K ++ G + LLEAQ ATG +IDP + RL V+ A G
Sbjct: 3833 VPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAG 3892
Query: 1797 YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQT 1856
E+ E L G+ DP T + ++ Q ++ + E G+ LL + Q+ T
Sbjct: 3893 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL-----EAQIAT 3947
Query: 1857 SQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 1899
++DP + + V AY++G D E + L +
Sbjct: 3948 GG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 3980
Score = 65.9 bits (159), Expect = 4e-10
Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%)
Query: 1737 VTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG 1796
V + P +S++QAM K ++ G + LLEAQ ATG +IDP + RL V+ A G
Sbjct: 4367 VPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAG 4426
Query: 1797 YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQT 1856
E+ E L G+ DP T + ++ Q ++ + E G+ LL + Q+ T
Sbjct: 4427 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL-----EAQIAT 4481
Query: 1857 SQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 1899
++DP + + V AY++G D E + L +
Sbjct: 4482 GG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 4514
Score = 65.9 bits (159), Expect = 4e-10
Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%)
Query: 1737 VTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG 1796
V + P +S++QAM K ++ G + LLEAQ ATG +IDP + RL V+ A G
Sbjct: 4901 VPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAG 4960
Query: 1797 YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQT 1856
E+ E L G+ DP T + ++ Q ++ + E G+ LL + Q+ T
Sbjct: 4961 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL-----EAQIAT 5015
Query: 1857 SQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 1899
++DP + + V AY++G D E + L +
Sbjct: 5016 GG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 5048
Score = 62.8 bits (151), Expect = 4e-09
Identities = 43/168 (25%), Positives = 80/168 (47%), Gaps = 8/168 (4%)
Query: 1456 TGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGF-----DDPFSGKTVSVSE 1510
T GI+ P L + +++ + D ++ I G D P + +S+ +
Sbjct: 4858 TSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQ 4917
Query: 1511 AIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQ 1570
A+ K ++ T + LLEAQ A+G V+DPV ++ L + A+A G++ ++ L +
Sbjct: 4918 AMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAV 4977
Query: 1571 KNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPV 1618
+ DP T +++S Q ++ I G+ LL Q ++ G+ PV
Sbjct: 4978 TGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQ---IATGGVIDPV 5022
Score = 55.5 bits (132), Expect = 6e-07
Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 16/203 (7%)
Query: 2027 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2086
E L K+S RG+ ++ L T GI+ P T + L+ Q V + D
Sbjct: 2701 ERLSKVSF-----RGLRRQVSASELH-----TSGILGPETLRDLAQGTKTLQEVTEMDSV 2750
Query: 2087 TRLKPAQKAFIGF-----EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPE 2141
R G + ++KMS +A+ + L LE Q TG ++DP
Sbjct: 2751 KRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPV 2810
Query: 2142 VHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGL 2201
+ R+S EEA+ G + G ++L T P T +IS A+ + ++ G+
Sbjct: 2811 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI 2870
Query: 2202 RLLEAASVSSKGLPSPYNMSSAP 2224
RLLE A +++ G+ P + P
Sbjct: 2871 RLLE-AQIATGGVIDPVHSHRVP 2892
Score = 55.5 bits (132), Expect = 6e-07
Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 16/203 (7%)
Query: 2027 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2086
E L K+S RG+ ++ L T GI+ P T + L+ Q V + D
Sbjct: 3235 ERLSKVSF-----RGLRRQVSASELH-----TSGILGPETLRDLAQGTKTLQEVTEMDSV 3284
Query: 2087 TRLKPAQKAFIGF-----EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPE 2141
R G + ++KMS +A+ + L LE Q TG ++DP
Sbjct: 3285 KRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPV 3344
Query: 2142 VHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGL 2201
+ R+S EEA+ G + G ++L T P T +IS A+ + ++ G+
Sbjct: 3345 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI 3404
Query: 2202 RLLEAASVSSKGLPSPYNMSSAP 2224
RLLE A +++ G+ P + P
Sbjct: 3405 RLLE-AQIATGGVIDPVHSHRVP 3426
Score = 55.5 bits (132), Expect = 6e-07
Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 16/203 (7%)
Query: 2027 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2086
E L K+S RG+ ++ L T GI+ P T + L+ Q V + D
Sbjct: 3769 ERLSKVSF-----RGLRRQVSASELH-----TSGILGPETLRDLAQGTKTLQEVTEMDSV 3818
Query: 2087 TRLKPAQKAFIGF-----EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPE 2141
R G + ++KMS +A+ + L LE Q TG ++DP
Sbjct: 3819 KRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPV 3878
Query: 2142 VHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGL 2201
+ R+S EEA+ G + G ++L T P T +IS A+ + ++ G+
Sbjct: 3879 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI 3938
Query: 2202 RLLEAASVSSKGLPSPYNMSSAP 2224
RLLE A +++ G+ P + P
Sbjct: 3939 RLLE-AQIATGGVIDPVHSHRVP 3960
Score = 55.5 bits (132), Expect = 6e-07
Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 16/203 (7%)
Query: 2027 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2086
E L K+S RG+ ++ L T GI+ P T + L+ Q V + D
Sbjct: 4303 ERLSKVSF-----RGLRRQVSASELH-----TSGILGPETLRDLAQGTKTLQEVTEMDSV 4352
Query: 2087 TRLKPAQKAFIGF-----EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPE 2141
R G + ++KMS +A+ + L LE Q TG ++DP
Sbjct: 4353 KRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPV 4412
Query: 2142 VHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGL 2201
+ R+S EEA+ G + G ++L T P T +IS A+ + ++ G+
Sbjct: 4413 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI 4472
Query: 2202 RLLEAASVSSKGLPSPYNMSSAP 2224
RLLE A +++ G+ P + P
Sbjct: 4473 RLLE-AQIATGGVIDPVHSHRVP 4494
Score = 55.5 bits (132), Expect = 6e-07
Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 16/203 (7%)
Query: 2027 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2086
E L K+S RG+ ++ L T GI+ P T + L+ Q V + D
Sbjct: 4837 ERLSKVSF-----RGLRRQVSASELH-----TSGILGPETLRDLAQGTKTLQEVTEMDSV 4886
Query: 2087 TRLKPAQKAFIGF-----EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPE 2141
R G + ++KMS +A+ + L LE Q TG ++DP
Sbjct: 4887 KRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPV 4946
Query: 2142 VHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGL 2201
+ R+S EEA+ G + G ++L T P T +IS A+ + ++ G+
Sbjct: 4947 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI 5006
Query: 2202 RLLEAASVSSKGLPSPYNMSSAP 2224
RLLE A +++ G+ P + P
Sbjct: 5007 RLLE-AQIATGGVIDPVHSHRVP 5028
Score = 37.4 bits (85), Expect = 0.17
Identities = 35/150 (23%), Positives = 62/150 (41%), Gaps = 7/150 (4%)
Query: 2074 DAVSQGVIDQDMATRL------KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRF 2127
++ Q + + MA L +P ++ G + S A+++ LP GQ
Sbjct: 15 NSTEQASVPRAMAATLGAGTPPRPQARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQAL 74
Query: 2128 LEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYK 2187
LE Q TGGLVD + +A+++G + ++L P K++
Sbjct: 75 LEAQAATGGLVDLARGQLLPVSKALQQGLVGLELKEKLLAAERATTGYPDPYGGEKLALF 134
Query: 2188 DAINRSMVEDITGLRLLEAASVSSKGLPSP 2217
AI + +V+ G LE +++ GL P
Sbjct: 135 QAIGKEVVDRALGQSWLE-VQLATGGLVDP 163
>gi|156104874 envoplakin [Homo sapiens]
Length = 2033
Score = 243 bits (620), Expect = 2e-63
Identities = 147/378 (38%), Positives = 224/378 (59%), Gaps = 19/378 (5%)
Query: 1831 KERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLID 1890
KER ++D + +E ++ QT + N K + I++PET K+MS EAYK+G+ID
Sbjct: 1655 KERTLRDLHAKVSR---EELSQETQTRETNLSTK--ISILEPETGKDMSPYEAYKRGIID 1709
Query: 1891 YETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRS 1950
+ +L E EC+WEE+T +G G V+L DRK+G QY I+ A+ + ++ + Y+
Sbjct: 1710 RGQYLQLQELECDWEEVTTSGPCGEESVLL-DRKSGKQYSIEAALRCRRISKEEYHLYKD 1768
Query: 1951 GSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSF 2010
G L +++FA +++ + +S S+GS +S +S +S S S SF
Sbjct: 1769 GHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSP------------SF 1816
Query: 2011 SDTL-EESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQK 2069
S L ++S PIA I+DT K SI + + ++D ITGQ+LLEAQA TGGI+ + ++
Sbjct: 1817 SLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRER 1876
Query: 2070 LSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLE 2129
S+ A+ +G+I+ RL AQKAF G E KK++S EAV++ W+P E+ L+
Sbjct: 1877 YSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQ 1936
Query: 2130 FQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDA 2189
Q+LTGGL+DP+ GRI ++A+ G I AQ LQD SSY K LT P +K ++SYK+A
Sbjct: 1937 VQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEA 1996
Query: 2190 INRSMVEDITGLRLLEAA 2207
+ R + ++GL LL AA
Sbjct: 1997 MGRCRKDPLSGLLLLPAA 2014
Score = 176 bits (446), Expect = 2e-43
Identities = 267/1129 (23%), Positives = 495/1129 (43%), Gaps = 141/1129 (12%)
Query: 790 RLTEEETVCLDLD-KVEAYRCGLK-KIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYP 847
RL E+E V D ++E +K +++ + + L A ++ QK Q+ S+ P
Sbjct: 953 RLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQP 1012
Query: 848 LYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRN-----------YRDNYQ 896
++VTQ+ D +D + L QI+QLR +
Sbjct: 1013 HL------LTKEVTQVER-----DPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELL 1061
Query: 897 AFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCAN 956
A K D K + E +K + +++ + E + +R ++EE +A+L A
Sbjct: 1062 ALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEA--VAKLQAR 1119
Query: 957 SIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRF 1016
I+D E ++S +E + + + + Q P +LQE++ + + E T++ R
Sbjct: 1120 -IEDLERAISS----VEPKVIVKEVKKVEQDPG--LLQESSRLRSLLEEERTKNATLARE 1172
Query: 1017 LSEMLKSLEDLKLKNTKIEVLE---EELRLARDANSENCNKNKFLDQNLQKYQAECSQFK 1073
LS++ ++ + K+++ E E ++ + E L + K + +
Sbjct: 1173 LSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVE 1232
Query: 1074 AKLASLEELKRQAE-LDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRF 1132
L LE L+ Q ++ K Q + + + + E+ +I RL ++ + +++
Sbjct: 1233 KLLPDLEVLRAQKPTVEYKEVTQEVVR-HERSPEVLREIDRLKAQLNELVNSHGRSQEQL 1291
Query: 1133 DQQKNDYDQLQKAR-QCEKENLGWQKLESEK-AIKEKEYEIERLRVLLQEEGTRKREYEN 1190
+ + + D+ ++ R + E + + + + EK + EKE ERLR ++E ++R E+
Sbjct: 1292 IRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKE--AERLRQEVREAAQKRRAAED 1349
Query: 1191 ELAKASNR---IQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE 1247
+ + ++ ++ K + VVQE + V ++D +L +E +R +L+ E
Sbjct: 1350 AVYELQSKRLLLERRKPEEKVVVQE-------VVVTQKDP----KLREEHSRLSGSLDEE 1398
Query: 1248 TRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREK-------SEREKNSLRSEI 1300
+++LE E QQ++ + + + S +E+ +K+ ERE E EK +
Sbjct: 1399 VGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQE 1458
Query: 1301 ERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRY----------QREIDKLRQRPYGS 1350
+ + E+ ++E+ LE ST + L+ E+++ Q +ID L Q+
Sbjct: 1459 KIIMEEVVKLEKD--PDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVL-QKAKSQ 1515
Query: 1351 HRETQTEC------EWTVDTSKLVFDGLRKKVTAMQLYECQ---LIDKTTLDKLLKGKKS 1401
+ E D V++ L ++ TA Q E + L ++ + L S
Sbjct: 1516 EKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWS 1575
Query: 1402 VEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIID 1461
EE SE+Q A G +E +L K+++ + + LL + +
Sbjct: 1576 REE--SELQRARDQADQECGRLQ--QELRALERQKQQQTLQLQEESKLLSQKTESERQKA 1631
Query: 1462 PHRNEKLT-VDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRE 1520
R ++L+ +++AI R+ + QIY E+ + S E + + RE
Sbjct: 1632 AQRGQELSRLEAAILRE------KDQIYEKERTLRDLHAKVS------REELSQETQTRE 1679
Query: 1521 TGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLND------------PRD 1568
T L +I+ +++P + A RG+IDR Y L + P
Sbjct: 1680 TN---LSTKIS---ILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCG 1733
Query: 1569 SQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGI 1628
+ +D + K+ S ++ RCR +S ++ + G P++ L+ +G
Sbjct: 1734 EESVLLDRKSGKQYS-IEAALRCR--------RISKEEYHLYKDG-HLPISEFALLVAGE 1783
Query: 1629 LRPST---VNELESGQISYDEVGERIKDFLQGSSC--------IAGIYNETTKQKLGIYE 1677
+PS+ + + S + F S IAGIY+ TT K I
Sbjct: 1784 TKPSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKT 1843
Query: 1678 AMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAV 1737
A+ ++ P T +LLEAQAATG IVD +S R V +A +RGL+ ++LL+A++A
Sbjct: 1844 AVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAF 1903
Query: 1738 TGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGY 1797
TG DP T +S+ +A+ K + + + L+ Q TGG+IDPK + R+P+ A G
Sbjct: 1904 TGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGM 1963
Query: 1798 FNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLP 1846
+EEL+++L D S K DP ++E L+Y + RC KD +GL LLP
Sbjct: 1964 ISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012
Score = 124 bits (312), Expect = 8e-28
Identities = 86/341 (25%), Positives = 163/341 (47%), Gaps = 10/341 (2%)
Query: 195 MRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEE 254
+ Q++ ++ +G +A +EQ I H + I Y QL + + +
Sbjct: 156 LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGP-----DAATIRSQ 210
Query: 255 YENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQ-KQEAFS 313
Y +LLKA+ R L L +Q +R++ + + + L DWSD + A ++E
Sbjct: 211 YRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEH 270
Query: 314 IRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLK 373
+ +L +E+ +N+L+ + +++V +HPA I+A+ + L+ +W L + C + L+
Sbjct: 271 FKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQ 330
Query: 374 ENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKR 433
Y +F EEA S L L ++ KY P E +++LE E +++ +R
Sbjct: 331 HVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTER 390
Query: 434 QVQNLVNKSKKIVQL-KPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSK 492
+L +S+ + L + RNP +P+ + ++CD+ + + +G+ L DN +
Sbjct: 391 ATGDLQRRSRDVAPLPQRRNP---PQQPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHA 447
Query: 493 WYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAI 533
W V GPGG P+ IP P+P AV + ++ +A+
Sbjct: 448 WVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQAL 488
Score = 102 bits (253), Expect = 6e-21
Identities = 175/824 (21%), Positives = 340/824 (41%), Gaps = 128/824 (15%)
Query: 993 LQEAADVHARYIELLTR-SGDYYRFLSEMLK----SLEDLKLKNTKIEVLEEELRLARDA 1047
L E + H R E L R G+ + E K ++ +++ K VLE+E R
Sbjct: 1277 LNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQE 1336
Query: 1048 NSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKEL 1107
E K + + + + Q++ + + + + ++ + K K L
Sbjct: 1337 VREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPK------------L 1384
Query: 1108 NEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEK 1167
E+ +RL+ +++E RR+ +E + QL+ + ++ L +Q+ S+K E+
Sbjct: 1385 REEHSRLSGSLDEEVGRRRQLE-------LEVQQLRAGVEEQEGLLSFQEDRSKKLAVER 1437
Query: 1168 EY--------EIERLRVLLQE----EGTRKREYENELAKASNRIQ----ESKNQCTQVVQ 1211
E E+E+ +QE E K E + +L K++ ++ + K Q T++ +
Sbjct: 1438 ELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNR 1497
Query: 1212 ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQ 1271
E ++L V+I VL++ K++ + + E+ R + + RV LE E+ ++ LN+ +T
Sbjct: 1498 ECKNLQVQIDVLQKAKSQEKTIYKEVIRVQ-----KDRV---LEDERARVWEMLNRERTA 1549
Query: 1272 YSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLET 1331
+EE R++ +++E + E LQ + ++ C R L+ R + Q +
Sbjct: 1550 RQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGR-LQQELRALERQKQQ 1608
Query: 1332 ERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTT 1391
+ + Q E L Q+ + E Q + + S+L LR+K Q+YE + +T
Sbjct: 1609 QTLQLQEESKLLSQK---TESERQKAAQRGQELSRLEAAILREKD---QIYEKE---RTL 1659
Query: 1392 LDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLE 1451
D L K S EE++ E Q + K S++E + K +SP
Sbjct: 1660 RD--LHAKVSREELSQETQT----------RETNLSTKISILEPETGKDMSPY------- 1700
Query: 1452 AQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA----EKAITGFDDPFSGKTVS 1507
+A GIID R + L + D +++ + E+++ D SGK S
Sbjct: 1701 -EAYKRGIID--RGQYLQLQELEC-------DWEEVTTSGPCGEESV--LLDRKSGKQYS 1748
Query: 1508 VSEAIKKNLIDRET-------GMRLLEAQIASGGVVDPVNSVFLPKDVALA--------- 1551
+ A++ I +E + + E + G P +S+ + ++ +
Sbjct: 1749 IEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQS 1808
Query: 1552 RGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSF 1611
L D D T K S + ++P TG LL Q +
Sbjct: 1809 TSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGI 1868
Query: 1612 QGI--RQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETT 1669
+ R+ +V + ++ G++ ++ L + Q ++ GI + T
Sbjct: 1869 VDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAF-----------------TGIEDPVT 1911
Query: 1670 KQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEK 1729
K++L + EA++ G + + L L+ Q TG ++DP R+P+++A G++ E +
Sbjct: 1912 KKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQL 1971
Query: 1730 LLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQI 1773
L DP + +S +AM + + G+ LL A +
Sbjct: 1972 LQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015
Score = 34.7 bits (78), Expect = 1.1
Identities = 47/180 (26%), Positives = 75/180 (41%), Gaps = 32/180 (17%)
Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAF--------IGFEGV----KGKKKM 2108
I+ P TG+ +S +A +G+ID+ +L+ + + G E V K K+
Sbjct: 1688 ILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEESVLLDRKSGKQY 1747
Query: 2109 SAAEAV------KEKWLPYEAGQRFL-EFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRA 2161
S A+ KE++ Y+ G + EF L G P +S I K + A
Sbjct: 1748 SIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPS--SSLSIGSIISKSPLASPA 1805
Query: 2162 AQR-----------LQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVS 2210
Q L D S + T K S K A+ ++M++ ITG +LLEA + +
Sbjct: 1806 PQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAAT 1865
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 224 bits (570), Expect = 1e-57
Identities = 391/1838 (21%), Positives = 751/1838 (40%), Gaps = 317/1838 (17%)
Query: 206 AWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFER 265
++G DL V+ + H HN + L K D + S +L +Y+ LL AS R
Sbjct: 153 SFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAK-DGDKEQNS---ELRAKYQKLLAASQAR 208
Query: 266 MDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQ-LEVKEK 324
HL LQ+ +Q + E+ W++ + + YDWSD+N + ++ + +++ LE KE+
Sbjct: 209 QQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEE 268
Query: 325 ELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKE-NAAYFQFFE 383
+NKL E DQL+ +HP + I+ H++ +A + ++
Sbjct: 269 RINKLHSEGDQLLAAEHPGRNS---------------------IEAHMEAVHADWKEYLN 307
Query: 384 EAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSK 443
E++LK ++D Q E K+ +++L R+V + +N+
Sbjct: 308 LLICEESHLKYMED-----------------YHQFHEDVKDAQELL---RKVDSDLNQKY 347
Query: 444 KIVQLKPRNPDYRSNKPI--ILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGV 501
PD++ I +LR L D +K++ K ++ +++ +R +
Sbjct: 348 --------GPDFKDRYQIELLLRELDD---QEKVLDKYED-VVQGLQKRGQ--------- 386
Query: 502 DMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIR 561
+VP P P+ V+ C E + +++ + + SW K+
Sbjct: 387 -QVVPLKYRRETPLKPIPVEALCDFEGE-QGLISRGYSYTLQKNNGESWELMDSAGNKLI 444
Query: 562 AMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQT 621
A + + + + L Y+ + + GS KR +Q + Y+
Sbjct: 445 APAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGS-------KRTLQQR-------YEV 490
Query: 622 LVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEH 681
L + PG +D Q +L L K+ ++
Sbjct: 491 LKTENPG------------------------------DASDLQGRQLLAGLDKVASDLDR 520
Query: 682 CEGRMTLKNLPLADQGSSHHITV-KINELKSVQNDSQAIAEVLNQL----KDMLANFRGS 736
E +T P +QG + + + +LK++ N+ I + + + GS
Sbjct: 521 QEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGS 580
Query: 737 EKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEET 796
L+ V +K E++ + D + L +++ Q+ ++L +E L +++T
Sbjct: 581 GTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDT 640
Query: 797 VCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKF 856
V +++ L + +L +KSLL ++ LQ A+Q S + ++ + DL +
Sbjct: 641 VPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQ 700
Query: 857 GEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMK 916
+V +L R+ + +Q++ R L+ ++ + ++L S E +
Sbjct: 701 EAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIP----SYEPQE 756
Query: 917 FGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANS------IKDYELQLASYTS 970
+ + L QKNL EI+ + +EVQKI CANS +KDYEL+
Sbjct: 757 TDSLSQMETKLKNQKNLLDEIASRE---QEVQKI---CANSQQYQQAVKDYELEAEK--- 807
Query: 971 GLETLLNIP-------IKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKS 1023
L +LL++ KR +QSP+ + +E A + A++ E+ Y + L++
Sbjct: 808 -LRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEV-------YAINRQRLQN 859
Query: 1024 LE---DLKLKNTKIEVLEEELRLAR-DANSENCNK-NKFLDQNLQKYQAECSQFKAKLAS 1078
LE +L + ++EV E L+ R D+ E K K LD
Sbjct: 860 LEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELD------------------- 900
Query: 1079 LEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQ--K 1136
EE +R+ +L+ ++K E+I L + E RK V + +
Sbjct: 901 -EETERRRQLEN------------EVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLE 947
Query: 1137 NDYDQLQK--ARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAK 1194
+ QLQ+ A + K L ++LE+ + +LR L QE +EY + K
Sbjct: 948 ESFQQLQRTLAEEQHKNQLLQEELEALQL---------QLRALEQETRDGGQEY---VVK 995
Query: 1195 ASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL 1254
RI+ + Q +V+Q RE L + +A + L+ R + E ++R ++++
Sbjct: 996 EVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQ---RVAALAEEKSRAQEKV 1052
Query: 1255 -ECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER 1313
E E ++QND Q + +Y + +E ++ + REK E E + L+ +++RL+ E E +
Sbjct: 1053 TEKEVVKLQND-PQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGK 1111
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
K E E + E E S R+ + + S RE +TE L
Sbjct: 1112 ITVK-EVLKVEKDAATEREVSDLTRQYEDEAAKARASQRE-KTE--------------LL 1155
Query: 1374 KKVTAMQLYECQLIDKTTLDKLLK-GKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSL 1432
+K+ A++ +++ + + ++++ K+ EVA+ + GA + S
Sbjct: 1156 RKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSE 1215
Query: 1433 VEAKRKKLISPESTVMLLEAQAATGGII----DPHRNEKLT------VDSAIARDLIDFD 1482
+EA R++ P+ +E + T +I DP ++L VD + D +
Sbjct: 1216 LEALRRR--GPQ-----VEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLE 1268
Query: 1483 DRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSV 1542
IY +K I D K + +E +L+ Q DP
Sbjct: 1269 ----IYQLKKEIQALKDT------------KPQVQTKEVVQEILQFQ------EDPQTK- 1305
Query: 1543 FLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERC------RIEPH 1596
++VA R + + + ++ R+ + + +K+ ++KER R E
Sbjct: 1306 ---EEVASLRAKLSEEQKKQVDLERERASQ-EEQIARKEEELSRVKERVVQQEVVRYEEE 1361
Query: 1597 TGLLL-LSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFL 1655
GL S S+ + + EL R +LE + E ++
Sbjct: 1362 PGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQ 1421
Query: 1656 QGSSCIAGIYNETTKQKLGIYEAMKIGLVR-PGTA-------LELLEAQAATGFIVDPVS 1707
+ +A + E + + + K+ L + P A L+L E Q + +
Sbjct: 1422 RLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELE 1481
Query: 1708 NLRLPVEEAYKRGLVGIEFKEKLLSAE--RAVTGYNDPETGNIISLFQAMNKELIEKGHG 1765
LR + K E KEK++ +E + G + E + S + ++ E
Sbjct: 1482 TLRRKLAALEKA-----EVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVE 1536
Query: 1766 IRLLEAQIATGGIIDPK----------ESHRLPVD---IAYKRGYFNEELSEILSDPSD- 1811
+ LEA+++ + K E+H+L ++ + + E++ ++ D
Sbjct: 1537 VSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDL 1596
Query: 1812 --DTKGFFDPNTEENLTYLQLK----ERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKR 1865
T N + L L+ + +R KD++ + L + V+ Q+ +R
Sbjct: 1597 RNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRR 1656
Query: 1866 RVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKT 1925
+V++ P+T +E+S +EA++ GLID+ F +L QEC+WEEI++ G +G + V+ DRK+
Sbjct: 1657 SIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVI-HDRKS 1715
Query: 1926 GSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMIS 1963
G ++ I++A+ G + +D+Y + +S+ + A ++S
Sbjct: 1716 GKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVS 1753
Score = 33.1 bits (74), Expect = 3.2
Identities = 21/85 (24%), Positives = 44/85 (51%), Gaps = 7/85 (8%)
Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
+IHP TG++LS ++A G+ID +M +L+ + +E + K + + ++
Sbjct: 1660 VIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQE---CDWEEISVKGPNGESSVIHDR--- 1713
Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGR 2145
++G++F + L G + P + R
Sbjct: 1714 -KSGKKFSIEEALQSGRLTPAQYDR 1737
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 132 bits (331), Expect = 5e-30
Identities = 115/478 (24%), Positives = 212/478 (44%), Gaps = 56/478 (11%)
Query: 1437 RKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITG 1496
+K L+ ++ ++LLE+Q G+I P E L+++ IAR+LI+ QQ+ + A+
Sbjct: 2 QKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALAL 61
Query: 1497 FDDPFSGK-TVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLI 1555
+ +SV EAI+K +I G+++LEA +A+GG + + + A +GLI
Sbjct: 62 ISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLI 121
Query: 1556 DRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIR 1615
L+ L + KN +DP T +K+ + L +RC + +G LL V++ + ++
Sbjct: 122 SAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLK 181
Query: 1616 --QPVTVTELVDSGIL-RPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQK 1672
+ V++ V G++ R TV LE+ + GI + T +
Sbjct: 182 SGRKVSIFRAVQEGLIDRQVTVRLLEAQLFA------------------GGIVDPRTGHR 223
Query: 1673 LGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLS 1732
L + EA++ L+ A +L Q TG I+D V+ RL ++EA LV + +L
Sbjct: 224 LTVEEAVRHNLIDQDMACAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILE 283
Query: 1733 AERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIA 1792
+ + G PE+G I+ + A+ + GI+ + +H++ +
Sbjct: 284 SLWSFMGLLWPESGEILPITDALEQ-------------------GIVSTELAHKILSNRQ 324
Query: 1793 YKRGYFNEELSEILSDPSDDTKGFFDPNTEENL---------TYLQLKERCIKDEETGLC 1843
+ + F +EILS G D + NL ++QL + ++ G
Sbjct: 325 HIKALFLPATTEILSWKKAIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAA 384
Query: 1844 LLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQE 1901
+LP + + SQ L + T+ ++VQ + L+D E + L ++
Sbjct: 385 VLPCSKSHPKATASQSENL------LFQLMTHSYINVQNGQRLLLLDKELMETLTSRD 436
Score = 123 bits (309), Expect = 2e-27
Identities = 117/454 (25%), Positives = 207/454 (45%), Gaps = 46/454 (10%)
Query: 1428 EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQI 1487
+K L EA + ++ + V L+E G D E LT + I L+D +
Sbjct: 744 QKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKLLHNV 803
Query: 1488 YAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKD 1547
A+KAI+G DP + SV +A+ L+D+ET R+LE Q+ +GG++D +
Sbjct: 804 LMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVT 863
Query: 1548 VALARGLID-RDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQK 1606
+A GL+D D +N + S+ + ++++ +Q++ I+P + L VQ
Sbjct: 864 LASTLGLVDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQS 923
Query: 1607 RSMSFQGIRQPVTV--TELVDSGI------LRPSTVNELESGQISYDEVGERIKDFLQGS 1658
+ V + ++VD GI +R S N G I +++ E++K +
Sbjct: 924 IDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIG-EDLAEKLKRV--EN 980
Query: 1659 SCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYK 1718
I I+N TK+ + + +A+K+ L+ E+ E QA TG VD +S RL + EA K
Sbjct: 981 LNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKK 1040
Query: 1719 RGLV------------GI----------------EFKEKLLSAER--AVTGYNDPETG-- 1746
GL+ GI + K + S +R V ++D + G
Sbjct: 1041 EGLLTNEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVS 1100
Query: 1747 -NIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEI 1805
+++L QA+ ++ +++LEAQ TGGIID RL + A + +E + I
Sbjct: 1101 DKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENMVRI 1160
Query: 1806 LSDPSDDTKGFFDPNTEENLTYLQ-LKERCIKDE 1838
++ G D +++ +T ++ +++R I E
Sbjct: 1161 IASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPE 1194
Score = 118 bits (295), Expect = 8e-26
Identities = 122/494 (24%), Positives = 213/494 (43%), Gaps = 69/494 (13%)
Query: 1663 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 1722
GI++E T QKL + EA+ G+V TA++L+E D + L EE GL+
Sbjct: 736 GIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLM 795
Query: 1723 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 1782
+ +L A++A++G DP T + S+ A+ L++K R+LE Q+ TGGIID K
Sbjct: 796 DEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLK 855
Query: 1783 ESHRLPVDIAYKRGYFN--------------------EELSEILSDPSDDTKGFFDPNTE 1822
++ V +A G + + + E L +T G DP+++
Sbjct: 856 RGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSK 915
Query: 1823 ENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQE 1882
LT +Q +R + + E + LL KQV I+ + +SV
Sbjct: 916 APLTVVQSIDRGLLEREEAVRLLT-----KQVVDGG----------IIHHISGMRLSVDN 960
Query: 1883 AYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDR 1942
A++ GLI ++L E+ E + I + + +T + AI L+
Sbjct: 961 AFRHGLIG----EDLAEKLKRVENLNIHQ--------IFNPETKENISLPKAIKLDLITS 1008
Query: 1943 KFFDQYRSGSLSLTQFADMIS--------------LKNGVGTSSSMGSGVSDDVFSSSRH 1988
+ + F D+IS L N S M G+ D
Sbjct: 1009 DLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVLSPGMMHGIVDP------- 1061
Query: 1989 ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITG 2048
E+ + V+ I S LE P + I D + + +++++ I+ G VD +
Sbjct: 1062 ENCRIVPYSELVKKCKIDIESGQRYLEVI-PFSDIKDGVSDKVLTLSQAIQLGKVDFAST 1120
Query: 2049 QRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKM 2108
++LEAQA TGGII TG++L+L A+ + ++D++M + Q G + +++
Sbjct: 1121 LKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRV 1180
Query: 2109 SAAEAVKEKWLPYE 2122
+ EA++++ + E
Sbjct: 1181 TLVEAIEKRLISPE 1194
Score = 117 bits (292), Expect = 2e-25
Identities = 98/413 (23%), Positives = 186/413 (45%), Gaps = 56/413 (13%)
Query: 1679 MKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVT 1738
M+ GL+ T L LLE+Q ++ P + L +EE R L+ + ++L + A+
Sbjct: 1 MQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALA 60
Query: 1739 GYND-PETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGY 1797
+ E+ +S+ +A+ K +I + G+++LEA +ATGG + + ++ A+ +G
Sbjct: 61 LISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGL 120
Query: 1798 FNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTS 1857
+ L +L +K DPNT E + L L +RCI +E+G LLP+K+
Sbjct: 121 ISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGG---- 176
Query: 1858 QKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTR 1917
+V ++ +++S+ A ++GLID + L E + G
Sbjct: 177 -----------MVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQ------LFAGG----- 214
Query: 1918 VVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSG 1977
+VD +TG + +++A+ L+D+ L D ++ G ++
Sbjct: 215 --IVDPRTGHRLTVEEAVRHNLIDQDMACAILIRQLQTGGIIDTVT-----GQRLTIDEA 267
Query: 1978 VSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEG 2037
VS+D+ + +KI+ + LE + E+ E + IT+
Sbjct: 268 VSNDLVA-------AKIALV---------------ILESLWSFMGLLWPESGEILPITDA 305
Query: 2038 IERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLK 2090
+E+GIV + ++L + + P T + LS + A+ G++D+D+A LK
Sbjct: 306 LEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLK 358
Score = 108 bits (269), Expect = 8e-23
Identities = 162/780 (20%), Positives = 303/780 (38%), Gaps = 73/780 (9%)
Query: 1421 GASASPKEK-YSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLI 1479
G S SP E +L EA + LIS +L + +IDP+ EK+ + + R ++
Sbjct: 100 GFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIV 159
Query: 1480 DFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPV 1539
+ ++ ++ G SG+ VS+ A+++ LIDR+ +RLLEAQ+ +GG+VDP
Sbjct: 160 HQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPR 219
Query: 1540 NSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGL 1599
L + A+ LID+D+ ++ + +D VT ++++ + + L
Sbjct: 220 TGHRLTVEEAVRHNLIDQDMACAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIAL 279
Query: 1600 LLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSS 1659
++L + SF G+ P +SG + P T + LE G +S E+ +I L
Sbjct: 280 VIL---ESLWSFMGLLWP-------ESGEILPIT-DALEQGIVS-TELAHKI---LSNRQ 324
Query: 1660 CIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKR 1719
I ++ T + L +A++ G++ A L V P L E+
Sbjct: 325 HIKALFLPATTEILSWKKAIESGILDRDLANNLKSICIPD---VMPHMQLADSAEQNINP 381
Query: 1720 GLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGII 1779
G +L ++ ++ N+ LFQ M I +G RLL +
Sbjct: 382 GAA-------VLPCSKSHPKATASQSENL--LFQLMTHSYINVQNGQRLLLLDKELMETL 432
Query: 1780 DPKESHRLPVDIAYKRGYFNEELSEILSDPSD-DTKGFFDPNTEENLTYLQLKERCIKDE 1838
++ ++ + G+ ++ E L + ++ G F L Q + +
Sbjct: 433 TSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYP 492
Query: 1839 ETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVD-PETNKEMSVQEAYKKGLIDY------ 1891
+ C K KK V+T + + + V+ E N + + K ++
Sbjct: 493 DREDCTTE-KGKKTTVETEDSSVENPEQDLFVEQKERNPNIDALKVINKVKLEVQRQLIG 551
Query: 1892 -----ETFKELCEQECEWEEITITGSDGSTRVVLVDRKT--------------GSQYDIQ 1932
+T + E +TI ++ ++VD+ + + Q
Sbjct: 552 TQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEHQPLRNTSFTCQ 611
Query: 1933 DAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVS 1992
+ L D+ + + +K +G + S +V + E +
Sbjct: 612 NEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLK 671
Query: 1993 KI-------STISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDS 2045
K +N+ S S+ +E IF +S + +E +++
Sbjct: 672 KTFLAKDDHKESQEAQNIAGGSMMMSEKTDEEDSGREIF-------LSCSHPLE--LLEE 722
Query: 2046 ITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGK 2105
T +L AQ GGI H TGQKL L +A+S+G++ A +L F GF +
Sbjct: 723 AT-LNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTC 781
Query: 2106 KKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRL 2165
+ ++ E + E + + L G++DP S ++A+ G +D A R+
Sbjct: 782 ESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRI 841
Score = 101 bits (251), Expect = 1e-20
Identities = 115/486 (23%), Positives = 209/486 (43%), Gaps = 56/486 (11%)
Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
S+ +A L+ E+ +LE Q TGGIID R +K++V A L+D D+ ++
Sbjct: 823 SVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINL 882
Query: 1491 EKA--------------------ITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQI 1530
EKA TG DP S ++V ++I + L++RE +RLL Q+
Sbjct: 883 EKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQV 942
Query: 1531 ASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFV-DPVTKKKVSYVQLKE 1589
GG++ ++ + L D A GLI DL L + + + +P TK+ +S + +
Sbjct: 943 VDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIK 1002
Query: 1590 RCRIEPHTGLLLLSVQKRSMSFQGI--RQPVTVTELVDSGILRPSTVNELESGQISYDEV 1647
I + VQ + +F + Q +T+ E G+L V L G +
Sbjct: 1003 LDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAV--LSPGMMH---- 1056
Query: 1648 GERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVS 1707
+ +C Y+E K+ KI + LE++ I D VS
Sbjct: 1057 -----GIVDPENCRIVPYSELVKK-------CKIDIESGQRYLEVIPFSD----IKDGVS 1100
Query: 1708 NLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIR 1767
+ L + +A + G V K+L A+ G D TG ++L A+ ++L+++
Sbjct: 1101 DKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENMVRI 1160
Query: 1768 LLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILS-DPSDDTKGFFDPNTEENLT 1826
+ Q+ GGI+D R+ + A ++ + EL+ ++ D S+ + +E +
Sbjct: 1161 IASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIE 1220
Query: 1827 YLQL------KERCIKDEETG-LCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPE---TNK 1876
L K+ I +T + ++E ++ Q ++ K +V + D E ++
Sbjct: 1221 VCALQNEFLGKDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSR 1280
Query: 1877 EMSVQE 1882
E+S++E
Sbjct: 1281 EISLKE 1286
Score = 97.1 bits (240), Expect = 2e-19
Identities = 107/473 (22%), Positives = 194/473 (41%), Gaps = 83/473 (17%)
Query: 1741 NDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNE 1800
++ ++G I L + EL+E+ + +L AQ+ GGI + +L ++ A RG
Sbjct: 701 DEEDSGREIFLSCSHPLELLEEAT-LNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPS 759
Query: 1801 ELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKN 1860
+ L + + +GFFD T E+LT ++ + DE+ N
Sbjct: 760 HTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKL-----------------LHN 802
Query: 1861 TLRKRRVV--IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRV 1918
L + + ++DP T SV++A GL+D ET + E++ +TG
Sbjct: 803 VLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQ------VVTGG------ 850
Query: 1919 VLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV 1978
++D K G + + A GLVD AD L N
Sbjct: 851 -IIDLKRGKKVSVTLASTLGLVD----------------VADQPELIN------------ 881
Query: 1979 SDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGI 2038
+ +S+ K T+R S +E + + D ++ +++ + I
Sbjct: 882 ---LEKASKGRDAEK----------TVRERLISLQMETT----GLIDPDSKAPLTVVQSI 924
Query: 2039 ERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFI- 2097
+RG+++ RLL Q GGIIH +G +LS+ +A G+I +D+A +LK + I
Sbjct: 925 DRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIH 984
Query: 2098 GFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFI 2157
+ K+ +S +A+K + + + E Q TG VD R++ EA ++G +
Sbjct: 985 QIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLL 1044
Query: 2158 DGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVS 2210
A + + P+ + Y + + + ++ +G R LE S
Sbjct: 1045 TNEAVL----SPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFS 1093
Score = 95.5 bits (236), Expect = 5e-19
Identities = 87/378 (23%), Positives = 168/378 (44%), Gaps = 42/378 (11%)
Query: 1832 ERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDY 1891
++ + D++TGL LL + QV S ++ PET + +S++E + LI+
Sbjct: 2 QKGLLDQDTGLVLL-----ESQVIMSG----------LIAPETGENLSLEEGIARNLINP 46
Query: 1892 ETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ--YDIQDAIDKGLVDR----KFF 1945
+ +++L E + + L+ R T S+ + +AI+K ++ K
Sbjct: 47 QMYQQLRELQ--------------DALALISRLTESRGPLSVVEAIEKRIISETVGLKIL 92
Query: 1946 DQY-RSGSLSLTQFADMISLKNGV--GTSSSMGSGVSDDVFSSSRH----ESVSKISTIS 1998
+ + +G SL+ + I+L+ G S+ V + +S++ + KI +
Sbjct: 93 EAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGLLD 152
Query: 1999 SVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACT 2058
++ + S L + ++ K+SI ++ G++D RLLEAQ
Sbjct: 153 LMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFA 212
Query: 2059 GGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKW 2118
GGI+ P TG +L++++AV +IDQDMA + Q G ++++ EAV
Sbjct: 213 GGIVDPRTGHRLTVEEAVRHNLIDQDMACAILIRQLQTGGIIDTVTGQRLTIDEAVSNDL 272
Query: 2119 LPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCP 2178
+ + LE + GL+ PE + +A+ +G + A ++ + K L P
Sbjct: 273 VAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALFLP 332
Query: 2179 KTKLKISYKDAINRSMVE 2196
T +S+K AI +++
Sbjct: 333 ATTEILSWKKAIESGILD 350
Score = 79.3 bits (194), Expect = 4e-14
Identities = 57/204 (27%), Positives = 100/204 (49%), Gaps = 7/204 (3%)
Query: 1386 LIDKTTLDK-----LLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKL 1440
LID T +K L++ +E ++ P + AG + + K S+ A ++ L
Sbjct: 139 LIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSG--RKVSIFRAVQEGL 196
Query: 1441 ISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDP 1500
I + TV LLEAQ GGI+DP +LTV+ A+ +LID D I + G D
Sbjct: 197 IDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACAILIRQLQTGGIIDT 256
Query: 1501 FSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLY 1560
+G+ +++ EA+ +L+ + + +LE+ + G++ P + LP AL +G++ +L
Sbjct: 257 VTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELA 316
Query: 1561 RSLNDPRDSQKNFVDPVTKKKVSY 1584
+ R K P T + +S+
Sbjct: 317 HKILSNRQHIKALFLPATTEILSW 340
Score = 77.4 bits (189), Expect = 1e-13
Identities = 49/168 (29%), Positives = 84/168 (50%), Gaps = 1/168 (0%)
Query: 2038 IERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFI 2097
+++G++D TG LLE+Q G+I P TG+ LSL++ +++ +I+ M +L+ Q A
Sbjct: 1 MQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALA 60
Query: 2098 GFEGV-KGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGF 2156
+ + + +S EA++++ + G + LE TGG I+ EEA +G
Sbjct: 61 LISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGL 120
Query: 2157 IDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
I L+ +K L P T KI D + R +V +G +LL
Sbjct: 121 ISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLL 168
Score = 67.8 bits (164), Expect = 1e-10
Identities = 87/414 (21%), Positives = 170/414 (41%), Gaps = 58/414 (14%)
Query: 1755 MNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTK 1814
M K L+++ G+ LLE+Q+ G+I P+ L ++ R N ++ + L + D
Sbjct: 1 MQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRE-LQDAL 59
Query: 1815 GFFDPNTEEN--LTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDP 1872
TE L+ ++ E+ I E GL +L + + T + + P
Sbjct: 60 ALISRLTESRGPLSVVEAIEKRIISETVGLKIL-----EAHLATGGFS---------LSP 105
Query: 1873 ETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQ 1932
N ++++EA+ +GLI W ++ S T L+D T + +
Sbjct: 106 SENC-INLEEAFHQGLIS------------AWLH-SVLESYLRTSKNLIDPNTAEKIGLL 151
Query: 1933 DAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVS 1992
D + + +V ++ SG ++ +K G S+ SG +F + + +
Sbjct: 152 DLMQRCIVHQE------SGF-------KLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLID 198
Query: 1993 KISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLL 2052
R +T+R LE I D ++++ E + ++D +L
Sbjct: 199 --------RQVTVR------LLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACAIL 244
Query: 2053 EAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAE 2112
Q TGGII TGQ+L++ +AVS ++ +A + + +F+G + + + +
Sbjct: 245 IRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITD 304
Query: 2113 AVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQ 2166
A+++ + E + L + L P +S ++AI G +D A L+
Sbjct: 305 ALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLK 358
Score = 64.7 bits (156), Expect = 1e-09
Identities = 61/296 (20%), Positives = 133/296 (44%), Gaps = 12/296 (4%)
Query: 1380 QLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKK 1439
Q++ + + +L K +K ++ EIQ G+ + ++ +L EAK++
Sbjct: 985 QIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISG--QRLTLAEAKKEG 1042
Query: 1440 LISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDD 1499
L++ E+ + + GI+DP + + + ID + Q+ Y + D
Sbjct: 1043 LLTNEAVL----SPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQR-YLEVIPFSDIKD 1097
Query: 1500 PFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDL 1559
S K +++S+AI+ +D + +++LEAQ +GG++D L AL L+D ++
Sbjct: 1098 GVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENM 1157
Query: 1560 YRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVT 1619
R + + VD + ++V+ V+ E+ I P L +Q S F R +
Sbjct: 1158 VRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPE---LANMIQIDSSEFSDHRAQIE 1214
Query: 1620 VTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGI 1675
E ++ L+ + + I+ ++ E + ++ S + + N++ ++K+ +
Sbjct: 1215 KQEGIEVCALQNEFLG--KDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKV 1268
Score = 53.9 bits (128), Expect = 2e-06
Identities = 186/967 (19%), Positives = 376/967 (38%), Gaps = 155/967 (16%)
Query: 415 LEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQK 474
L+Q++ L+ E +K L+ ++ ++ + +S+K ++ + P +L+ + +D
Sbjct: 2309 LKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDV- 2367
Query: 475 IVHKGDECILKDNNER----SKWYVTG--PGGVDMLVPSVGLIIPPPNPLAVDLSC-KIE 527
I HKGD + + ++ + G P + LV L A+ C ++
Sbjct: 2368 ISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK-LKDATERYTALHSKCTRLG 2426
Query: 528 QYYEAILALWNQLYINMKSLVSW-HYCMIDIEKIRAMTIAKLKTMRQEDYMKT------I 580
+ +L ++Q + SL +W C ++EK+ + T+A + QE T +
Sbjct: 2427 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 2486
Query: 581 ADLEL---HYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTT 637
A+ ++ Q+ R+ E D R +Q H+Q+L L + ++
Sbjct: 2487 AEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA---ERSSLLQ 2543
Query: 638 TEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQG 697
I + Q+ + + E + L Q E M LK +A Q
Sbjct: 2544 KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQ-EALATNMKLKQ-DIARQK 2601
Query: 698 SSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKL---- 753
SS T ++ DS A + +L ++ F E+ C Q E +KL
Sbjct: 2602 SSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRF---EQLCLQQQEKESSLKKLLPQA 2658
Query: 754 ---ENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCG 810
E+++G ++ + R L +D+ ++ +++
Sbjct: 2659 EMFEHLSGKLQQFMENKS--RMLASGNQPDQDITHFFQ--------------QIQELNLE 2702
Query: 811 LKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRI 870
++ + +L+ + L+ TEL + LDL + ++V L + +
Sbjct: 2703 MEDQQENLDTLEHLV----TELSSCG------------FALDLCQHQDRVQNLRKDFTEL 2746
Query: 871 DKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQ 930
K + R D +QL +R + F KWL + + E+ + + + +
Sbjct: 2747 QKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM--SAKELEKQIEHL 2804
Query: 931 KNLHSEISGKRDKSEEVQKIAELC-ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPS 989
K+L + + K EE+ C S+++ +++ + S +T +P + + S +
Sbjct: 2805 KSLLDDWASKGTLVEEIN-----CKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVN 2859
Query: 990 GV--------ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDL-KLKNTKIEVLE-- 1038
G I + +DV+ +Y +L + L +L +E++ K N+ ++ LE
Sbjct: 2860 GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK 2919
Query: 1039 EELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLD 1098
EE+ + DA S + +A+ KA LA LE QN
Sbjct: 2920 EEVLKSMDAMSS--------PTKTETVKAQAESNKAFLAELE--------------QNSP 2957
Query: 1099 KCYGQIKELNEKITRL--TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLG-- 1154
K I+++ E + L TY E K +++ + + ++ ARQ + E
Sbjct: 2958 K----IQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASH 3013
Query: 1155 ---WQKLESEKA--IKEKEYEI-----------------ERLRVLLQEEGTRKREYE--N 1190
+Q ES+ + EKE + ++++ +L+E R++++E N
Sbjct: 3014 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLN 3073
Query: 1191 ELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRV 1250
E A+ + T VQ K L+ + L D+LN S ++ + V
Sbjct: 3074 EAAQGILTGPGDVSLSTSQVQ---------KELQSINQKWVELTDKLNSRSSQID-QAIV 3123
Query: 1251 KQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSER---EKNSLRSEIERLQAEI 1307
K + Q++ DL++ ++ I ++ E ++ E + +RS++E+L E+
Sbjct: 3124 KST---QYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 3180
Query: 1308 KRIEERC 1314
K + C
Sbjct: 3181 KEAQTLC 3187
Score = 48.1 bits (113), Expect = 1e-04
Identities = 136/746 (18%), Positives = 280/746 (37%), Gaps = 127/746 (17%)
Query: 709 LKSVQNDSQAIAEVLNQLKDMLANFRGS---EKYCYLQNEVFGLFQKLENINGVTDGYLN 765
L ++ +S I +V L +L + S E + +Q E+ +++ + L
Sbjct: 2949 LAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLE 3008
Query: 766 SLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLL 825
+ A QA E L+ + L E+E + L L N LN +K +
Sbjct: 3009 ESASHLACFQA---AESQLRPW---LMEKELMMGVLGP-------LSIDPNMLNAQKQQV 3055
Query: 826 ATMKTELQKAQQIHSQTSQQYPLY-------DLDLGKFGEKVTQLTDRWQRIDKQIDFRL 878
M E + +Q H Q ++ L + +++ + +W + +++ R
Sbjct: 3056 QFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRS 3115
Query: 879 WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
+++ I + Y++ Q + + +R S++S V + L E + S++
Sbjct: 3116 SQIDQAIVKSTQYQELLQDLSEKVRAVGQRL-SVQSAISTQPEAVKQQLEETSEIRSDLE 3174
Query: 939 GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
+ +E Q + + + I + L+ LET + P + AAD
Sbjct: 3175 QLDHEVKEAQTLCDELSVLIGEQYLK-DELKKRLET----------VALPLQGLEDLAAD 3223
Query: 999 VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFL 1058
R L + + + E+ L+D + + K + +L + EN K L
Sbjct: 3224 RINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSL 3283
Query: 1059 DQNLQKYQAECSQFKAKLAS-------------LEELKRQ-AELDGKSAKQN-------- 1096
+Q+ Y+ ++ ++ L S L ELK EL K+A +
Sbjct: 3284 NQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQ 3343
Query: 1097 ---------------LDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQ 1141
++ C ++ EL ++T ++E R K++ + +++++ +
Sbjct: 3344 KAQKYQWHVEDLVPWIEDCKAKMSEL--RVTLDPVQLESSLLRSKAMLNEVEKRRSLLEI 3401
Query: 1142 LQKAR-------QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAK 1194
L A + +++ + +K + + E++ L+E R RE++
Sbjct: 3402 LNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKN 3461
Query: 1195 ASNRIQESKNQCTQVVQERESLLVKIKVLEQDKAR---LQRLEDE--------------- 1236
+++ +K+Q ++ S K LE+ +A+ LQ LE +
Sbjct: 3462 IEKKVEGAKHQL-EIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDA 3520
Query: 1237 ---------LNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESERE 1287
L++A+ + VKQR+ ++N L + R E ++ +
Sbjct: 3521 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580
Query: 1288 KSE------REKNSLRSEIER----------LQAEIKRIEERCRRKLEDSTRETQSQLET 1331
+ + R+ +SL+S+IE L+ +I+ E CR LE+ L+
Sbjct: 3581 ELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKR 3640
Query: 1332 ERSRYQREIDKLRQRPYGSHRETQTE 1357
E ++ KL +R G R+ Q E
Sbjct: 3641 ELEALNKQCGKLTER--GKARQEQLE 3664
Score = 48.1 bits (113), Expect = 1e-04
Identities = 113/609 (18%), Positives = 251/609 (41%), Gaps = 84/609 (13%)
Query: 738 KYCYLQNEVFGLFQKLENINGVTDGYLNSLC-----TVRALLQAILQT-EDMLKVYEARL 791
K+ L+N+V +E +N + L S ++R+ L+A+ Q E +L+ E R
Sbjct: 4809 KHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEERE 4868
Query: 792 TEEETVCLDLD----KVEAYRCGLKKIKNDLNLKK---SLLATMKTELQKAQQIHSQTSQ 844
+ ++ ++E + L ++++ L+ K L T + +L +++SQ
Sbjct: 4869 QQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKA 4928
Query: 845 QYPLYD--LDLGKF----------GEKVTQ----LTDRWQRIDKQIDFRLWDLEKQIKQL 888
+ Y+ LD G+ G K Q L +W + +++ R LE+ +
Sbjct: 4929 KEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLA 4988
Query: 889 RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
++++ Q F WL A++ ++ S NTV+ + E K +E++ RD+ E+
Sbjct: 4989 TEFQNSLQEFINWLTLAEQSL-NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELD 5047
Query: 949 KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
+ +L+ S + + N+ + +QS ++Q + + +
Sbjct: 5048 QTGN---------QLKFLSQKQDVVLIKNLLVS---VQSRWEKVVQRSIERGRSLDDARK 5095
Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDAN--SENCNKNKFLDQNLQKYQ 1066
R+ ++ +++ LED + L+ EL ++ D + +K+K + L Q
Sbjct: 5096 RAKQFHEAWKKLIDWLEDAE------SHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQ 5149
Query: 1067 AECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRK 1126
+ + + LK + L S Q LD G++++ + + + E R+
Sbjct: 5150 ---PVYDTTIRTGRALKEKTLLPEDS--QKLDNFLGEVRDKWDTVCGKSVE------RQH 5198
Query: 1127 SVEDRFDQQKNDYDQLQKARQCEKENLGW-QKLESEKAIKEKEYEIERLRVLLQEEGTRK 1185
+E+ D LQ + W K+E + A + + L + L +
Sbjct: 5199 KLEEALLFSGQFMDALQAL-------VDWLYKVEPQLAEDQPVHGDLDLVMNLMD---AH 5248
Query: 1186 REYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNR-AKSTL 1244
+ ++ EL K + +Q K ++++ + K +LQ L + K ++
Sbjct: 5249 KVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV------KGQLQELSTRWDTVCKLSV 5302
Query: 1245 EAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQ 1304
++R++Q L+ + + ++ ++ S E+ +R R + +L+S I+ +
Sbjct: 5303 SKQSRLEQALK-QAEVFRDTVHMLLEWLSEAEQTLR----FRGALPDDTEALQSLIDTHK 5357
Query: 1305 AEIKRIEER 1313
+K++EE+
Sbjct: 5358 EFMKKVEEK 5366
Score = 47.0 bits (110), Expect = 2e-04
Identities = 116/579 (20%), Positives = 238/579 (41%), Gaps = 51/579 (8%)
Query: 858 EKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917
+ + ++ + W+ ++K RL LE ++ Y+D QA WL + + ++ +
Sbjct: 4629 KSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVG- 4687
Query: 918 GDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC---ANSIKDYELQLASYTSGLET 974
D NTV LNE K E+ ++ + E++ EL A D ++ T
Sbjct: 4688 TDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHL 4747
Query: 975 LLNIPIKRTMIQSP-SGVILQEAADVHA--RYIELLTRSGDYYRFLSEMLKSLEDLKLKN 1031
N+ K Q G +L HA + LT + + + + ++++
Sbjct: 4748 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVEL 4807
Query: 1032 TKIEVLEEELRLARDANSENCNK--NKFLDQNLQKYQAECSQFKAKLASLEELKRQAELD 1089
K VL+ ++ LA A E NK N+ L+ + + S +++L ++ +
Sbjct: 4808 AKHHVLKNDV-LAHQATVETVNKAGNELLESSAGD---DASSLRSRLEAMNQC------- 4856
Query: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCE 1149
+S Q ++ Q++ ++ EIED +E + K + AR+
Sbjct: 4857 WESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQL 4916
Query: 1150 KENLGWQKLESEKAIKEKEY----EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQ 1205
++ +L S+ KE+ Y + RL +L +++ + E +A +++ +
Sbjct: 4917 DTHM---ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVA----LLEQKWHV 4969
Query: 1206 CTQVVQERESLLVK-IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQ-- 1262
+ ++ER+S L + + + + + LQ + L A+ +L + L QI+
Sbjct: 4970 VSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEH 5029
Query: 1263 ----NDLNQWKTQYSRKEEAIRKIE--SEREKSEREKNSLRSEIERLQAEIKRIEERCRR 1316
N++N + Q ++ +++ S+++ KN L S R + ++R ER R
Sbjct: 5030 KVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER-GR 5088
Query: 1317 KLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
L+D+ + + E +++ ID L + +E E + D K+ + K
Sbjct: 5089 SLDDARKRAKQFHEA----WKKLIDWLED----AESHLDSELEISNDPDKIKLQLSKHKE 5140
Query: 1377 TAMQLYECQLIDKTTL--DKLLKGKKSVEEVASEIQPFL 1413
L Q + TT+ + LK K + E + ++ FL
Sbjct: 5141 FQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFL 5179
Score = 47.0 bits (110), Expect = 2e-04
Identities = 106/513 (20%), Positives = 197/513 (38%), Gaps = 81/513 (15%)
Query: 801 LDKVEAYRCGLKKIKNDLNLKKSLLATMK---TELQKAQQIHSQTSQQYPLY------DL 851
LD C + + DLN K L MK E+ + Q + + Q L +
Sbjct: 4673 LDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDET 4732
Query: 852 DLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDS 911
D E +T+L W+ + ++I R LE + L ++ + WL + D+
Sbjct: 4733 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA 4792
Query: 912 LESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIA-ELCANSIKDYELQLASYTS 970
+ GD + L + L +++ + E V K EL +S D L S
Sbjct: 4793 QRPIS-GDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLE 4851
Query: 971 GLETLLNIPIKRT-----MIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLE 1025
+ +++T +QS LQ+A H+ +E
Sbjct: 4852 AMNQCWESVLQKTEEREQQLQS----TLQQAQGFHS---------------------EIE 4886
Query: 1026 DLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEEL--K 1083
D L+ T+ +E +L ++ + LD +++ Y SQ KAK + +L K
Sbjct: 4887 DFLLELTR---MESQLSASKPTGGLPETAREQLDTHMELY----SQLKAKEETYNQLLDK 4939
Query: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQ 1143
+ L + + K + L +K ++ ++E+ K + ++ N + Q
Sbjct: 4940 GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK-------SKLEEALNLATEFQ 4992
Query: 1144 KARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI---Q 1200
+ Q E + W L + + VL Q E + + NE+ ++I
Sbjct: 4993 NSLQ---EFINWLTLAEQSLNIASPPSLILNTVLSQIE--EHKVFANEVNAHRDQIIELD 5047
Query: 1201 ESKNQCTQVVQERESLLVK----------IKVLEQDKARLQRLEDELNRAKSTLEAETRV 1250
++ NQ + Q+++ +L+K KV+++ R + L+D RAK EA ++
Sbjct: 5048 QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKL 5107
Query: 1251 KQRLECEKQ------QIQNDLNQWKTQYSRKEE 1277
LE + +I ND ++ K Q S+ +E
Sbjct: 5108 IDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 5140
Score = 44.7 bits (104), Expect = 0.001
Identities = 113/627 (18%), Positives = 238/627 (37%), Gaps = 78/627 (12%)
Query: 850 DLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQ 909
D D+ + ++ RW ++K++ R+ L++ + ++D + WL D +
Sbjct: 3743 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3802
Query: 910 DSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYT 969
+ + + V + EQK L + ++ + +Q A S +LA
Sbjct: 3803 AN-QKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS-----AELADRE 3856
Query: 970 SGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKL 1029
L ++ + T + S + ++ D+ + + FLS K L + +
Sbjct: 3857 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP 3916
Query: 1030 KNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELD 1089
T+ +++++ ++K L+++++ + + Q SL L AE
Sbjct: 3917 VGTQTAKIQQQI-----------IRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-- 3963
Query: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR--- 1146
G + E + + EI+D R+ ++ D+ L AR
Sbjct: 3964 -----------QGVLSEKIDSLQARYSEIQDRCCRKAALLDQ---------ALSNARLFG 4003
Query: 1147 QCEKENLGWQKLESEK--AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
+ E E L W +K ++ K+++ + L + E N I+ +
Sbjct: 4004 EDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQA 4063
Query: 1205 QCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQND 1264
Q E E LL++ K L+ K R + ++A TLE ++ + + +++
Sbjct: 4064 LLKQTTGE-EVLLIQEK-LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW 4121
Query: 1265 LNQWKTQ------YSRKEEAIRKIESEREKSEREKNSLR------SEIERLQAEIK--RI 1310
L + + + S E I + + +++ ++E R +E+ R E+ R
Sbjct: 4122 LREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRA 4181
Query: 1311 EERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTS-KLVF 1369
E + + D+ + + +T R EID QR + E W +T KL+
Sbjct: 4182 REGLDKLVSDANEQYKLVSDTIGQRVD-EIDAAIQRSQQYEQAADAELAWVAETKRKLMA 4240
Query: 1370 DG---LRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASP 1426
G L + T QL + K +++ K S++E+ S G
Sbjct: 4241 LGPIRLEQDQTTAQLQ----VQKAFSIDIIRHKDSMDELFSHRSEIFGTCG--------- 4287
Query: 1427 KEKYSLVEAKRKKLISPESTVMLLEAQ 1453
+E+ ++++ K + LI + LL ++
Sbjct: 4288 EEQKTVLQEKTESLIQQYEAISLLNSE 4314
Score = 43.5 bits (101), Expect = 0.002
Identities = 96/522 (18%), Positives = 195/522 (37%), Gaps = 93/522 (17%)
Query: 859 KVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFG 918
++ +L + W+ + K+ R L+ +++ + Y+ + + W+ D K + L
Sbjct: 3316 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTL-- 3373
Query: 919 DSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNI 978
D + L K + +E+ +R E + A++ NS + E + +G+
Sbjct: 3374 DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGIN----- 3428
Query: 979 PIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLE 1038
++ A EL ++G + + E K K+E +
Sbjct: 3429 ------------------QNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAK 3470
Query: 1039 EELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKR------QAELDGKS 1092
+L + S+ C+ ++NL+K +A+ +A ++ L+ + DG
Sbjct: 3471 HQLEIFDALGSQACS-----NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSD 3525
Query: 1093 AKQNLDKC------YGQIKE-LNEKITRLTYEIEDEKRRRKSVEDRFDQQKN-------- 1137
A Q L + + ++K+ +N + ++E + V + F Q +
Sbjct: 3526 ASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGM 3585
Query: 1138 -----DYDQLQKARQCEKENLGWQKLESEKA-IKEKEYEIERLRVLLQEEGTRKREYENE 1191
D D LQ Q E L K+ K I+ E E R +L+EEGT +
Sbjct: 3586 GAIGRDTDSLQS--QIEDVRLFLNKIHVLKLDIEASEAE---CRHMLEEEGTL------D 3634
Query: 1192 LAKASNRIQESKNQCTQVVQ----ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE 1247
L ++ QC ++ + +E L + + +E +L+ L D A+ +
Sbjct: 3635 LLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQ 3694
Query: 1248 TRVKQRLECEKQQIQ--------------------NDLNQWKTQYSRKEEAIRKIESERE 1287
V +E QQ+ N L Q Q + K+ ++ +E + E
Sbjct: 3695 WVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME 3754
Query: 1288 KSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQL 1329
+ N+L ++ + A+++ C K +D+ S L
Sbjct: 3755 EINARWNTLNKKVAQRIAQLQEALLHC-GKFQDALEPLLSWL 3795
Score = 42.4 bits (98), Expect = 0.005
Identities = 74/411 (18%), Positives = 159/411 (38%), Gaps = 57/411 (13%)
Query: 1060 QNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEI- 1118
+N++ + + LA L++L QA++ + K +++ +N+ I E+
Sbjct: 1818 RNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVP 1877
Query: 1119 --------EDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYE 1170
+D K +KS+ D + Q A + EK + Q + E +++
Sbjct: 1878 AQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAW 1937
Query: 1171 IERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIK--------- 1221
+ ++L +G+ + L + ++ K + + ++L I+
Sbjct: 1938 VGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQD 1997
Query: 1222 ----------------------VLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQ 1259
+LEQ A++ L+ L + + +T KQ+ C +Q
Sbjct: 1998 LSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQ 2057
Query: 1260 QIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCR---R 1316
DL W Q R + ++++ S +KN +S+++ LQ +I+ +
Sbjct: 2058 --LEDLCSWVGQAERALAGHQGRTTQQDLSALQKN--QSDLKDLQDDIQNRATSFATVVK 2113
Query: 1317 KLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWT----VDTSKLVFDGL 1372
+E E Q++L RE+ LR++ + + + + E T + + V L
Sbjct: 2114 DIEGFMEENQTKLS------PRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSAL 2167
Query: 1373 RKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGAS 1423
+++ + + +K +D LL SV ++ L G ++GAS
Sbjct: 2168 QQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGAS 2218
Score = 41.2 bits (95), Expect = 0.012
Identities = 142/777 (18%), Positives = 282/777 (36%), Gaps = 146/777 (18%)
Query: 743 QNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLD 802
Q E L + L+ L LC+ + Q E L ++ R T++ DL
Sbjct: 2037 QMEQEALVKTLQKQQNTCHQQLEDLCSW------VGQAERALAGHQGRTTQQ-----DLS 2085
Query: 803 KVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQ 862
++ + LK +++D+ + + AT+ +++ + Q L +L EK+ Q
Sbjct: 2086 ALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFME-----ENQTKLSPRELTALREKLHQ 2140
Query: 863 LTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNT 922
++++ + ++ +LE+ + K L + K++ D+L ++
Sbjct: 2141 AKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSS 2200
Query: 923 VMRFLN-----EQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLN 977
+ L EQ + S G D ++ + + K E+ A + L N
Sbjct: 2201 GGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQN 2260
Query: 978 IPIKRTMIQS------------PSGVILQEAADVHARYIELLTRSGDYYRFLS----EML 1021
+ Q+ ++ Q+ ++ +Y L +S + + E+
Sbjct: 2261 FILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQ 2320
Query: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
K L+D K + +E E+EL EN +K + L F + S +
Sbjct: 2321 KFLQDHKEFESWLERSEKEL--------ENMHKGGSSPETLPSLLKRQGSFSEDVISHKG 2372
Query: 1082 LKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR---------- 1131
R + G+ +++ + + KE +E + +++D R ++ +
Sbjct: 2373 DLRFVTISGQKVL-DMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNM 2431
Query: 1132 ----FDQQKNDYDQLQKARQ-CE------------------KENLGWQKLESEKAIKEKE 1168
+ Q +N D LQ Q CE +E L K + ++ + E +
Sbjct: 2432 LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTK-QLQEELAEHQ 2490
Query: 1169 YEIERL----RVLLQEEGTRKREYEN-----------------ELAKASNRIQESKNQCT 1207
+E+L R +++ EG ++ + LA+ S+ +Q++ Q
Sbjct: 2491 VPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQ 2550
Query: 1208 QVVQERESLLVKIKVLEQD-----------------KARLQRLEDELNRAKSTLEAETRV 1250
V + ESLL I +EQ+ A +L+ ++ R KS+LEA +
Sbjct: 2551 SVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREM 2610
Query: 1251 KQR-LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKR 1309
R +E L + S++ E + + E+E S ++ E L ++++
Sbjct: 2611 VTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQ 2670
Query: 1310 IEERCRRKLEDSTRETQ---------SQLETERSRYQREIDKLRQRPYGSHRETQ-TECE 1359
E R L + Q +L E Q +D L H T+ + C
Sbjct: 2671 FMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL------EHLVTELSSCG 2724
Query: 1360 WTVDTSKLV--FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLR 1414
+ +D + LRK T +Q T+ + K S +E E + +R
Sbjct: 2725 FALDLCQHQDRVQNLRKDFTELQ---------KTVKEREKDASSCQEQLDEFRKLVR 2772
Score = 39.7 bits (91), Expect = 0.034
Identities = 28/68 (41%), Positives = 36/68 (52%), Gaps = 4/68 (5%)
Query: 2208 SVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGS----FDATGNSSYSYSY 2263
S SS + + A +S SR GSR+GSR+GSR+ SRRGS FD S
Sbjct: 5838 SNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDT 5897
Query: 2264 SFSSSSIG 2271
S SS++ G
Sbjct: 5898 SESSAAGG 5905
Score = 32.3 bits (72), Expect = 5.4
Identities = 34/168 (20%), Positives = 70/168 (41%), Gaps = 14/168 (8%)
Query: 774 LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
LQA++ D L E +L E++ V DLD V K + +L + + +K +
Sbjct: 5214 LQALV---DWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLK---R 5267
Query: 834 KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
+++ + D ++ +L+ RW + K + LE+ +KQ +RD
Sbjct: 5268 SGRELIENSRD-------DTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRD 5320
Query: 894 NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKR 941
+WL +A++ ++ D+ + ++ K ++ KR
Sbjct: 5321 TVHMLLEWLSEAEQTLRFRGALP-DDTEALQSLIDTHKEFMKKVEEKR 5367
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 106 bits (265), Expect = 2e-22
Identities = 244/1201 (20%), Positives = 480/1201 (39%), Gaps = 170/1201 (14%)
Query: 213 SVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQ-----LEEEYENLLKASFERMD 267
SV + ++H+ + S +Y +++ +K +L + Y L+++ E + E +
Sbjct: 109 SVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSE 168
Query: 268 HLRQLQNI---IQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVK-- 322
L+ N ++ EI I EE++LY + +K+E + + +E
Sbjct: 169 QLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQ 228
Query: 323 --EKELNKLKQESDQL-VLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYF 379
+K +N L++E QL ++Q + L Q I+ KE+ A
Sbjct: 229 HYQKNINSLQEELLQLKAIHQEEVKE--------LMCQ----------IEASAKEHEAEI 270
Query: 380 QFFEEA-QSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREK---ILEYKRQV 435
E ++ + + +I+KKY C+ L++L + ++ + +L+ V
Sbjct: 271 NKLNELKENLVKQCEASEKNIQKKYECE----LENLRKATSNANQDNQICSILLQENTFV 326
Query: 436 QNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDN--NERSKW 493
+ +VN+ K+ L+ + S I L+ Y + K+ + D +KD +ER
Sbjct: 327 EQVVNE--KVKHLEDTLKELESQHSI-LKDEVTYMNNLKLKLEMDAQHIKDEFFHERE-- 381
Query: 494 YVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYC 553
D+ L++ + C IE+ + L Q +C
Sbjct: 382 --------DLEFKINELLLAKE-----EQGCVIEKLKSELAGLNKQ------------FC 416
Query: 554 MIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFT 613
+ R + K E + K I++L + F+ +S+ ++ + + ++ Q
Sbjct: 417 YTVEQHNREVQSLK------EQHQKEISELN---ETFLSDSEKEKLTLMFEIQGLKEQCE 467
Query: 614 DAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQ 673
+ Q+ Q ++ + + TE+ K+ + +Q+ + ELQ
Sbjct: 468 NLQQEKQEAILNYESLREIMEILQTELGESA-------GKISQEFESMKQQQASDVHELQ 520
Query: 674 -KIRRQIEHCEGRMTLKNLPLADQG---SSHHITVKI-NELKSVQNDSQAIAEVLNQLKD 728
K+R + + N + S + ++ N +K++Q + L+Q
Sbjct: 521 QKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDT 580
Query: 729 MLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYE 788
ML G K L E KL+N + D + L+ + + + Y
Sbjct: 581 MLKELEG--KINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYN 638
Query: 789 ARLTEEETVCLDLDKVEAYRCGLK-----KIKNDLNLKKSLLATMKTELQKAQQIHSQTS 843
+ L + KV GL+ K +ND L+K L+ MK + + + ++
Sbjct: 639 SELEQ---------KVNELTGGLEETLKEKDQNDQKLEK-LMVQMKVLSEDKEVLSAEVK 688
Query: 844 QQYPLYDLDLGKFGEKVTQLTDRW-----QRIDKQIDFRLWDLEKQIKQLRNYRDNYQAF 898
Y + K + QL+ Q+ D + + LEK+++ + +DN
Sbjct: 689 SLYE----ENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLN-- 742
Query: 899 CKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSI 958
K L + + ++ +++ +G FL E + SE S ++D +Q + E A I
Sbjct: 743 -KLLENEQVQKLFVKTQLYG-------FLKEMGSEVSEDSEEKDVVNVLQAVGESLAK-I 793
Query: 959 KDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIE---LLTRSGDYYR 1015
+ + LA E +L + + +Q S V +E + Y + LL + + +
Sbjct: 794 NEEKCNLAFQRD--EKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQ 851
Query: 1016 FLSEMLKS-LEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKA 1074
E L+S L ++K N K + + L + + S+ C+K++ ++ + + E K
Sbjct: 852 SEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKP 911
Query: 1075 KLASLEELKRQAELD------GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSV 1128
L E R+AEL KS D +KEL EKI L E ++++ + +
Sbjct: 912 LLEQKELRDRRAELILLKDSLAKSPSVKNDPL-SSVKELEEKIENLEKECKEKEEKINKI 970
Query: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEK---------------AIKEKEYEIER 1173
+ + K + D +K Q KE L + L SEK + K E E+
Sbjct: 971 KLVAVKAKKELDSSRKETQTVKEEL--ESLRSEKDQLSASMRDLIQGAESYKNLLLEYEK 1028
Query: 1174 LRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRL 1233
L E R +E+ + + +++ S QC + + E LL +I+ L+ + L+
Sbjct: 1029 QSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQ 1088
Query: 1234 EDELNRAKS----TLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESERE-- 1287
E+ RAK+ LEAE K++ E N+L + + Q ++++ ++K E E
Sbjct: 1089 ILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELV 1148
Query: 1288 KSEREKNSLR----SEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKL 1343
K + ++ +L ++ ERL E+ + K+ED +E + Q + + + Q EI L
Sbjct: 1149 KKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQET-LQEEITSL 1207
Query: 1344 R 1344
+
Sbjct: 1208 Q 1208
Score = 82.4 bits (202), Expect = 5e-15
Identities = 190/1078 (17%), Positives = 448/1078 (41%), Gaps = 166/1078 (15%)
Query: 243 REKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKN 302
++ S +++L+++ L+ +F D L + N +Q + +++ ++EL+ + +
Sbjct: 511 QQASDVHELQQK----LRTAFTEKDALLETVNRLQGENEKLL-----SQQELVPELENTI 561
Query: 303 TNIAQKQEAFSIRMSQLEVKEKEL----NKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
N+ +K + + +SQ + KEL N L +E D + + ++++ + + +
Sbjct: 562 KNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREE 621
Query: 359 SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
IL++ K ++ ++ N+ E Q GL++++++K D+ L+ L+ Q+
Sbjct: 622 RLILELGKKVEQTIQYNS------ELEQKVNELTGGLEETLKEKDQNDQK--LEKLMVQM 673
Query: 419 KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
K L +++E + S ++ L N S K + R L + + +
Sbjct: 674 KVLSEDKEVL-------------SAEVKSLYEENNKLSSEKKQLSRDL------EVFLSQ 714
Query: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
++ ILK++ + L + L++ + +L+ +E L +
Sbjct: 715 KEDVILKEH-------------ITQLEKKLQLMVEEQD----NLNKLLENEQVQKLFVKT 757
Query: 539 QLYINMKSLVSW------HYCMIDIEKIRAMTIAKLKT-------MRQEDYMKTIADLE- 584
QLY +K + S ++++ + ++AK+ R E ++ +++
Sbjct: 758 QLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKC 817
Query: 585 LHYQEFIRNSQGSEMFGDDDKRKI--QSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITH 642
L + ++ + + D ++ K+ + + + Q + L L T E
Sbjct: 818 LQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLE-NQ 876
Query: 643 HGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
+ Q ++ + ++++E + E + ++ +E E R L L +
Sbjct: 877 NLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSP 936
Query: 703 TVKINELKSVQNDSQAIAEVLNQLKDM--------LANFRGSEKYCYLQNEVFGLFQKLE 754
+VK + L SV+ + I + + K+ L + ++ + E + ++LE
Sbjct: 937 SVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELE 996
Query: 755 NINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI 814
++ D S+ R L+Q +++L YE + E + ++ ++ + ++ +
Sbjct: 997 SLRSEKDQLSASM---RDLIQGAESYKNLLLEYEK---QSEQLDVEKERANNFEHRIEDL 1050
Query: 815 KNDLNLK-----------KSLLATMKT-----ELQKAQQIHSQTSQQYPLYDLDLGKFGE 858
L + LLA ++T +L + Q + Q ++ +L+ K +
Sbjct: 1051 TRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKL-Q 1109
Query: 859 KVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFG 918
K ++ + +++ + ++ L+K+ KQL+ + K DA+ Q +L +M+
Sbjct: 1110 KEQKIKEHATTVNELEELQV-QLQKEKKQLQKTMQELELVKK---DAQ--QTTLMNMEIA 1163
Query: 919 DSNTVMRFLNEQ--------KNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTS 970
D +M+ LN++ ++L EI ++ K E +Q+ +S++ YE +
Sbjct: 1164 DYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEK------ 1217
Query: 971 GLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLK 1030
N IK+ ++++ + + A+ + L LK +L+
Sbjct: 1218 ------NTKIKQLLVKTKKELADSKQAETD-------------HLILQASLKG--ELEAS 1256
Query: 1031 NTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDG 1090
++EV + +L + SE ++ L + +++Q S ++ ++ +L+E R A+ +
Sbjct: 1257 QQQVEVYKIQLA---EITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQ 1313
Query: 1091 KSAKQNLD----KCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR 1146
+ + + + +K+ K + E E K+ R+ +E DQ K Q
Sbjct: 1314 ATVTSEFESYKVRVHNVLKQQKNK-SMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNL 1372
Query: 1147 QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQC 1206
Q L Q L+SE + +ER +LQE +++ E +L + K++
Sbjct: 1373 QINVSEL--QTLQSEH-----DTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEH 1425
Query: 1207 TQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQND 1264
TQ V + S ++ +D+ R L++E + TL+ + ++E + Q++N+
Sbjct: 1426 TQTVSQLTSQNEVLRNSFRDQVR--HLQEEHRKTVETLQQQL---SKMEAQLFQLKNE 1478
Score = 73.2 bits (178), Expect = 3e-12
Identities = 257/1431 (17%), Positives = 583/1431 (40%), Gaps = 219/1431 (15%)
Query: 49 TDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELD 108
TD+ + Q + +Q+ Q+ + + + L++ + I Q E+K +
Sbjct: 209 TDEKKETVTQLQNIIEANSQH-YQKNINSLQEELLQLKAIHQEEVKE---LMCQIEASAK 264
Query: 109 ECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKG 168
E A+ N E+ ++L+++ C+A +K + + E + +R+A+S
Sbjct: 265 EHEAEINKLNELKENLVKQ-------CEASEKNIQKKYE--------CELENLRKATSNA 309
Query: 169 G-GGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMD------------MVAWGVDLASVE 215
C + F + V +E + + E++ M + L
Sbjct: 310 NQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDA 369
Query: 216 QHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQ-LEEEYENLLKASFERMD-HLRQLQ 273
QHI + D ++++++ E+ + + L+ E L K ++ H R++Q
Sbjct: 370 QHIKDE--FFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQ 427
Query: 274 NIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQES 333
++ + +EI +N+ T ++ ++ M +++ +++ L+QE
Sbjct: 428 SLKEQHQKEISELNE--------------TFLSDSEKEKLTLMFEIQGLKEQCENLQQEK 473
Query: 334 DQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYF-QFFEEAQSTEAY- 391
+ +LN + + M+ LQT+ L E+A Q FE + +A
Sbjct: 474 QEAILNY----ESLREIMEILQTE--------------LGESAGKISQEFESMKQQQASD 515
Query: 392 LKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPR 451
+ LQ +R + +K+ LLE + L+ E EK+L + V L N K L+ +
Sbjct: 516 VHELQQKLRTAFT-EKDA----LLETVNRLQGENEKLLSQQELVPELENTIK---NLQEK 567
Query: 452 NPDY---RSNKPIILRALCDYKQDQKIVHKGDECI--LKDNNERSKWYVTGPGGVDMLVP 506
N Y S + +L+ L + + + D+ I LK+++E + + L+
Sbjct: 568 NGVYLLSLSQRDTMLKEL--EGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLIL 625
Query: 507 SVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIA 566
+G + +L K+ + + + N + L M + + + + A
Sbjct: 626 ELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA 685
Query: 567 KLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL 626
++K++ +E+ + +L + SQ ++ + +++ + + L L
Sbjct: 686 EVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLL 745
Query: 627 PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRM 686
+ T++ +G +++ ++V E + E D ++ LQ + + ++
Sbjct: 746 ENEQVQKLFVKTQL--YGFLKEMG-SEVSEDSEEKD-----VVNVLQAVGESL----AKI 793
Query: 687 TLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEV 746
+ LA Q + ++ E+K +Q +S E +LK +L ++ + E
Sbjct: 794 NEEKCNLAFQRDEKVLELE-KEIKCLQEESVVQCE---ELKSLLRDY---------EQEK 840
Query: 747 FGLFQKLENINGVTDGYLNSLCTVR-ALLQAILQTEDMLKVYEARLTEEETVCLDLD-KV 804
L ++LE I + + L ++ A + L+ +++L ++ E C +
Sbjct: 841 VLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLL----IQVEEVSQTCSKSEIHN 896
Query: 805 EAYRCGLKKIKN--------DLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKF 856
E +C +K+ +N +L +++ L +K L K+ + + PL + +
Sbjct: 897 EKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKND-----PLSSVK--EL 949
Query: 857 GEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMK 916
EK+ L + +++I+ K K+L + R Q + L + +D L +
Sbjct: 950 EEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSA-- 1007
Query: 917 FGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLL 976
+++ KNL E + ++ + ++ A + I+D QL + T ET
Sbjct: 1008 --SMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCET-- 1063
Query: 977 NIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEV 1036
I + D+ AR IE L + ++ + + K + E
Sbjct: 1064 ---------------INSDNEDLLAR-IETLQSNAKLLEVQILEVQRAKAMVDKELEAEK 1107
Query: 1037 LEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQN 1096
L++E ++ A + N L++ + Q E Q + + LE +K+ A+ ++ N
Sbjct: 1108 LQKEQKIKEHATTVN-----ELEELQVQLQKEKKQLQKTMQELELVKKDAQ---QTTLMN 1159
Query: 1097 LDKCYGQ--IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-RQCEKENL 1153
++ + +KELN+K+T +IED ++ K + + + + + LQ + +Q E++N
Sbjct: 1160 MEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNT 1219
Query: 1154 GWQKL--ESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQ 1211
++L +++K + + + + E ++LQ + EL + +++ K Q ++
Sbjct: 1220 KIKQLLVKTKKELADSK-QAETDHLILQ------ASLKGELEASQQQVEVYKIQLAEITS 1272
Query: 1212 ERESLLVKIK--------VLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQN 1263
E+ + +K L + R+ L++E AK+ + V E K ++ N
Sbjct: 1273 EKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKA---EQATVTSEFESYKVRVHN 1329
Query: 1264 DLNQWKTQYSRKEEAIRKIESEREKSERE----------------KNSLR---SEIERLQ 1304
L Q +K +++ + E+E K ERE +N+L+ SE++ LQ
Sbjct: 1330 VLKQ------QKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQ 1383
Query: 1305 AEIKRIEERCRRKLEDST------RETQSQLETE----RSRYQREIDKLRQRPYGSHRET 1354
+E + ER + L+++ RE +++E +S + + + +L +
Sbjct: 1384 SEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSF 1443
Query: 1355 QTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV 1405
+ + + + + L+++++ M+ QL ++ T + ++S++ +
Sbjct: 1444 RDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNL 1494
Score = 67.4 bits (163), Expect = 2e-10
Identities = 189/953 (19%), Positives = 383/953 (40%), Gaps = 160/953 (16%)
Query: 812 KKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQR-- 869
K ++ NL+K L M T+L+ ++Q+ Q + + ++ K E++ ++ ++
Sbjct: 144 KYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSED-----NVKKLQEEIEKIRPGFEEQI 198
Query: 870 --IDKQIDFRLWDLEKQIKQLRNYRD-NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRF 926
+ KQ+D + ++ + QL+N + N Q + K + Q+ L +K
Sbjct: 199 LYLQKQLDATTDEKKETVTQLQNIIEANSQHYQK---NINSLQEELLQLK-------AIH 248
Query: 927 LNEQKNLHSEISGKRDKSE-EVQKIAELCANSIKDYELQ----LASYTSGLETLLNIPIK 981
E K L +I + E E+ K+ EL N +K E Y LE L
Sbjct: 249 QEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSN 308
Query: 982 RTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLED-LKLKNTKIEVLEEE 1040
++LQE V + ++E +K LED LK ++ +L++E
Sbjct: 309 ANQDNQICSILLQENTFVE--------------QVVNEKVKHLEDTLKELESQHSILKDE 354
Query: 1041 ------LRLARDANSENCNKNKFLDQN----------LQKYQAEC--SQFKAKLASL-EE 1081
L+L + ++++ F ++ L K + C + K++LA L ++
Sbjct: 355 VTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQ 414
Query: 1082 LKRQAELDGKSAKQNLDKCYGQIKELN---------EKITRLTYEIEDEKRRRKSVEDRF 1132
E + + ++ +I ELN EK+T L +EI+ K + ++++
Sbjct: 415 FCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLT-LMFEIQGLKEQCENLQQEK 473
Query: 1133 DQQKNDYDQLQKARQCEKENLG------WQKLESEK----------------AIKEKEYE 1170
+ +Y+ L++ + + LG Q+ ES K A EK+
Sbjct: 474 QEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDAL 533
Query: 1171 IERLRVLL--QEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLV----KIKVLE 1224
+E + L E+ ++E EL +QE + +R+++L KI L
Sbjct: 534 LETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLT 593
Query: 1225 QDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQ---QIQNDLNQWKTQYSRKEEAIRK 1281
++K +D +N+ K++ E ++ E E++ ++ + Q S E+ + +
Sbjct: 594 EEK------DDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNE 647
Query: 1282 IESEREKSEREKNSLRSEIERLQAEIKRIEE--RCRRKLEDSTRETQSQLETERSRYQRE 1339
+ E++ +EK+ ++E+L ++K + E S E ++L +E+ + R+
Sbjct: 648 LTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRD 707
Query: 1340 IDK-LRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKG 1398
++ L Q+ +E T+ E + D L K + Q+ +L KT L LK
Sbjct: 708 LEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQ--KLFVKTQLYGFLKE 765
Query: 1399 KKSVEEVASEIQPFLRGAGSIAGASAS-PKEKYSLVEAKRKKLISPESTVMLLEAQAAT- 1456
S SE + + ++ + A +EK +L + +K++ E + L+ ++
Sbjct: 766 MGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQ 825
Query: 1457 ----GGIIDPHRNEKLTV----------DSAIARDLIDFDDRQQIYAAEKAITGFDDPFS 1502
++ + EK+ + A+ DL++ + + E
Sbjct: 826 CEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEV 885
Query: 1503 GKTVSVSEAIKKN----LIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRD 1558
+T S SE + + + E LLE + + D + L KD +LA+ +
Sbjct: 886 SQTCSKSEIHNEKEKCFIKEHENLKPLLEQK----ELRDRRAELILLKD-SLAKSPSVK- 939
Query: 1559 LYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPV 1618
NDP S K ++K+ ++ + + + E + L++V+ + ++
Sbjct: 940 -----NDPLSSVKEL-----EEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQ 989
Query: 1619 TVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQ 1671
TV E ELES + D++ ++D +QG+ + E KQ
Sbjct: 990 TVKE-------------ELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQ 1029
Score = 44.3 bits (103), Expect = 0.001
Identities = 46/266 (17%), Positives = 121/266 (45%), Gaps = 18/266 (6%)
Query: 1163 AIKEKEYEIERLRVLLQEEGTR-KREYENELAKASNRIQESKNQCTQVVQERESLLVKIK 1221
A+ ++ E E+ + L++E + K+E E+ + K + +E + V+E E+L ++
Sbjct: 80 ALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELM 139
Query: 1222 VLE----QDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEE 1277
+ +DKA LQ+ +E + L + + + E +++Q ++ + + + +
Sbjct: 140 AVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQIL 199
Query: 1278 AIRK-----IESEREKSEREKNSLRSEIERLQAEIKRIEE---RCRRKLEDSTRETQSQL 1329
++K + ++E + +N + + + Q I ++E + + ++ +E Q+
Sbjct: 200 YLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQI 259
Query: 1330 ETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAM----QLYECQ 1385
E ++ EI+KL + ++ + + + + LRK + Q+
Sbjct: 260 EASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSIL 319
Query: 1386 LIDKTTLDKLLKGK-KSVEEVASEIQ 1410
L + T +++++ K K +E+ E++
Sbjct: 320 LQENTFVEQVVNEKVKHLEDTLKELE 345
Score = 43.1 bits (100), Expect = 0.003
Identities = 53/218 (24%), Positives = 101/218 (46%), Gaps = 10/218 (4%)
Query: 1199 IQESKNQCTQVVQERESLLVKIKVLEQD----KARLQRLEDELNRAKSTLEAETRVKQRL 1254
IQ++K++CT++ +E E L K V E KA +RL+ L T + +K+
Sbjct: 41 IQKAKSRCTELEKEIEELRSK-PVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKEN 99
Query: 1255 ECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEI-KRIEER 1313
KQ++++ + + + E++ E E + E ++RS+ +A + K++EE
Sbjct: 100 IKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEA 159
Query: 1314 CRRKLEDSTR-ETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGL 1372
+LE S + + Q+ E + Q EI+K+R Q + + T D K L
Sbjct: 160 MNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQL 219
Query: 1373 RKKVTA-MQLYECQLIDKTTLDKLLKGKKSVEEVASEI 1409
+ + A Q Y+ + + ++LL+ K +E E+
Sbjct: 220 QNIIEANSQHYQKNI--NSLQEELLQLKAIHQEEVKEL 255
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 103 bits (256), Expect = 3e-21
Identities = 155/753 (20%), Positives = 307/753 (40%), Gaps = 113/753 (15%)
Query: 653 KVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSV 712
+ ++T E+ T EL+ R Q +T+ L ++ SH ++ E++
Sbjct: 1149 EALKTELEDTLDSTATQQELRAKREQ------EVTVLKKALDEETRSHE--AQVQEMR-- 1198
Query: 713 QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
Q +QA+ E+ QL+ +K N+ Q LE N G L R
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDK-----NK-----QTLEKENADLAGEL------RV 1242
Query: 773 LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEA-YRCGLKKIKNDLNLKKSLL------ 825
L QA + E K EA++ E ++ C D ++ A + K++N++ +L
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 826 --------ATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFR 877
A++ ++LQ Q++ + ++Q L + E+ L D+ +D++++ +
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAK 1359
Query: 878 LWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEI 937
+LE+ I L N Q L D+K++ S RF E +NL +
Sbjct: 1360 Q-NLERHISTL-----NIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1408
Query: 938 SGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAA 997
K ++++K + D + L + + L K + + I + A
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468
Query: 998 D----VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCN 1053
D A E T++ R L E L++ E+L+ N ++ E+L ++D +N +
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 1054 K----NKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNE 1109
+ + L+ +++ + + + + +L + E+ K + E++ ++ K ++ E NE
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 1110 KITRLTY--------EIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE 1161
+ R E+EDE+++R + + D L+ L+++
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE--------------LQAD 1634
Query: 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENE-------LAKASNRIQESKNQCTQVVQERE 1214
AIK +E I++LR L + +RE E+ A A +++K+ ++Q +E
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1694
Query: 1215 SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSR 1274
L + +Q + L +EL + S A K+RLE Q++ +L + +
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 1275 KEEAIRKI---------------------ESEREKSEREKNSLRSEIERLQAEIKRIEER 1313
+ +RK ES R++ ER+ LRS++ ++ +K +
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1814
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1346
LE + + Q+E E Q L+Q+
Sbjct: 1815 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847
Score = 94.0 bits (232), Expect = 2e-18
Identities = 139/713 (19%), Positives = 315/713 (44%), Gaps = 64/713 (8%)
Query: 743 QNEVFGLFQKL--ENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLD 800
QN +KL E I+ +T + L + + E M+ E RL +EE +
Sbjct: 993 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1052
Query: 801 LDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKV 860
L+K++ +K++ D + +A ++ ++ ++ Q +++ L + +++
Sbjct: 1053 LEKLK------RKLEGDASDFHEQIADLQAQIA---ELKMQLAKKEEELQAALARLDDEI 1103
Query: 861 TQLTDRWQRIDKQIDFRLWDLEKQI-----------KQLRNYRDNYQAFCKWL---YDAK 906
Q + ++I ++++ + DL++ + KQ R+ + +A L D+
Sbjct: 1104 AQKNNALKKI-RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162
Query: 907 RRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966
Q L + + + + + L+E+ H E + + + Q + EL ++ ++ A
Sbjct: 1163 ATQQELRAKREQEVTVLKKALDEETRSH-EAQVQEMRQKHAQAVEEL-TEQLEQFKRAKA 1220
Query: 967 SYTSGLETL----LNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLK 1022
+ +TL ++ + ++ + + + A+ EL ++ D R +E+
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 1023 SLEDLKLKNTKIEVLEEE-----LRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
+ L+ + + + E ++LA+D S + ++ + + LQ+ + KL
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-SQLQDTQELLQEETRQKLNVSTKLR 1339
Query: 1078 SLEELKR--QAELDGK-SAKQNLDKCYGQI--------KELNEKITRLTYEIEDEKRRRK 1126
LEE + Q +LD + AKQNL++ + K+L + + + E +KR +K
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1399
Query: 1127 SVED---RFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
+E+ +++++ YD+L+K + Q E ++L + + E + + LL E
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459
Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRA 1240
E +Y +E +A +E + + + + E L + LE+ L+ ++L +
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519
Query: 1241 KSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEI 1300
K + LE K+ ++ + + KTQ E+ ++ E + + E +L+ +
Sbjct: 1520 KDDVGKNVH---ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Query: 1301 ER-LQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREI-DKLRQRPYGSHRETQTEC 1358
ER LQA ++ EE+ RR+L+ E +++LE ER QR + +++ G ++ + +
Sbjct: 1577 ERDLQARDEQNEEK-RRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDLKDLELQA 1633
Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLID-KTTLDKLLKGKKSVEEVASEIQ 1410
+ + + LRK M+ ++ +L D + + D++ K E+ A ++
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686
Score = 77.8 bits (190), Expect = 1e-13
Identities = 104/496 (20%), Positives = 231/496 (46%), Gaps = 65/496 (13%)
Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQ 1060
A Y++L R+ ++R +++ K L + + +++ E+EL+ ++ + N+ K L+Q
Sbjct: 824 AAYLKL--RNWQWWRLFTKV-KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ 880
Query: 1061 NLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED 1120
+ E + + E+L+ + EL Y + +E+ ++ E+E+
Sbjct: 881 KHSQLTEEKNLLQ------EQLQAETEL------------YAEAEEMRVRLAAKKQELEE 922
Query: 1121 EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
+E R +++++ QLQ E++ + Q L+ E+ ++E+E ++L++
Sbjct: 923 ILHE---MEARLEEEEDRGQQLQ----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 975
Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKAR-LQRL----ED 1235
+ ++ E+E+ ++ + + ++++ER S L E++KA+ L +L E
Sbjct: 976 AEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1034
Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
++ + L+ E + +Q LE K++++ D + + Q + + I +++ + K E E
Sbjct: 1035 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE--- 1091
Query: 1296 LRSEIERLQAEIKRIEERCR--RKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRE 1353
L++ + RL EI + + R+LE + Q L++ER+ R + ++R G E
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA--ARNKAEKQKRDLGEELE 1149
Query: 1354 T-QTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKT------TLDKLLKGKKSVEEVA 1406
+TE E T+D++ + K+ + + + L ++T + K ++VEE+
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1209
Query: 1407 SEIQPFLRGAGSI-AGASASPKEKYSL-------------VEAKRKKLISPESTVMLLEA 1452
+++ F R ++ KE L VE K+KKL E+ V L++
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQS 1266
Query: 1453 QAATGGIIDPHRNEKL 1468
+ + G N+K+
Sbjct: 1267 KCSDGERARAELNDKV 1282
Score = 49.7 bits (117), Expect = 3e-05
Identities = 176/1017 (17%), Positives = 391/1017 (38%), Gaps = 117/1017 (11%)
Query: 197 QQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYE 256
+Q+ +++ V + +E I +N + R L++ +DL A + EE+ +
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--EEEEKAK 1023
Query: 257 NLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRM 316
NL K + + +L+ ++ + + + + L D SD + IA Q +
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK-LEGDASDFHEQIADLQAQIAELK 1082
Query: 317 SQLEVKEKELNKLKQESDQLVLNQHPASDKI---EAYMDTLQTQWSWILQITKCIDVHLK 373
QL KE+EL D + ++ A KI E ++ LQ
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD---------SERAA 1133
Query: 374 ENAAYFQFFEEAQSTEAYLKGLQDSI-----RKKYPCDKNMPLQHLLEQIKELEKEREKI 428
N A Q + + EA L+D++ +++ + + L + + E + E
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193
Query: 429 LEYKRQ--VQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKD 486
++ RQ Q + ++++ Q K + NK + + D + +++ + + +
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1250
Query: 487 NNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYY---EAILALWNQLYIN 543
+++ K ++ V + +L+ K+ + E++ + N+
Sbjct: 1251 EHKKKK--------LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 544 MKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDD 603
L D+ + + + +++E K +L E RNS ++ D+
Sbjct: 1303 AIKLAK------DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL--DE 1354
Query: 604 DKRKIQSQFTDAQKHYQTLVIQLPGYPQ--HQTVTTTEITHHGTCQDVNHNKVIE--TNR 659
+ Q+ ++H TL IQL + +T E G + K IE T +
Sbjct: 1355 EMEAKQN----LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR---FQKEIENLTQQ 1407
Query: 660 ENDKQETWMLMELQKIRRQ-------IEHCEGRMTLKNLPLADQGSSHHITVKIN-ELKS 711
+K + +E K R Q ++ R + NL + + + N K
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1467
Query: 712 VQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVR 771
+A AE + L+ R E E ++LE N + + L + +
Sbjct: 1468 ADERDRAEAEAREKETKALSLARALE-------EALEAKEELERTNKMLKAEMEDLVSSK 1520
Query: 772 ALL-QAILQTEDMLKVYEARLTEEETVCLDL-DKVEAYRCGLKKIKNDLN-LKKSLLATM 828
+ + + + E + E ++ E +T +L D+++A +++ ++ LK +
Sbjct: 1521 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1580
Query: 829 KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVT-------QLTDRWQRIDKQIDFRLWDL 881
+ ++ ++ Q +Q Y+ +L ++ +L + ++ Q D +
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1640
Query: 882 EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKR 941
E+ IKQLR + + F + L DA+ +D + + + + L +++
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA-- 1698
Query: 942 DKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHA 1001
+E +K A+L + + +LAS SG R +Q + A +
Sbjct: 1699 --AERARKQADLEKEELAE---ELASSLSG----------RNALQDEKRRLEARIAQLEE 1743
Query: 1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQN 1061
EL G+ + K+ + + + ++ + A + +NK L
Sbjct: 1744 ---ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800
Query: 1062 LQ--------KYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITR 1113
L K+++ + +AK+A LEE Q + ++A ++L K+ ++K+
Sbjct: 1801 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL-------KQKDKKLKE 1853
Query: 1114 LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYE 1170
+ ++EDE++ + +++ ++ QL+ RQ E+ Q++ + + ++E +
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLK--RQLEEAEEESQRINANRRKLQRELD 1908
Score = 35.8 bits (81), Expect = 0.49
Identities = 87/401 (21%), Positives = 165/401 (41%), Gaps = 68/401 (16%)
Query: 55 GYCQTGTMSRHQNQNTIQELLQ-NCSDCL-MRAELIVQPELKYGDGIQLTRSRE----LD 108
GY ++ Q Q T +++Q NC+ L +R + K +Q+TR E +
Sbjct: 799 GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 858
Query: 109 ECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRA-LYKAISVPRVRRASSK 167
+ + ++ + ++ ++E+ Q +K LLQ Q Q LY RVR A+ K
Sbjct: 859 DELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYAEAEEMRVRLAAKK 917
Query: 168 GGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNS 227
+ E + E R Q+ + + + +E+ +
Sbjct: 918 Q------ELEEILHEMEARLEEE---EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 228 IGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIN 287
+ QL+K+ A+ + K +LE+E + ++ + L + + +++ ++ N
Sbjct: 969 L-----QLEKVTAEAKIK----KLEDE----ILVMDDQNNKLSKERKLLEERISDLT-TN 1014
Query: 288 DCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLN-QHPASDK 346
EEEE K N+ + + +S+LEV+ K+ K +QE ++L + ASD
Sbjct: 1015 LAEEEE-------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 347 IEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCD 406
E D LQ Q + LK Q ++ + +A L L D I +K
Sbjct: 1068 HEQIAD-LQAQIA-----------ELK-----MQLAKKEEELQAALARLDDEIAQK---- 1106
Query: 407 KNMPLQHLLEQIKELE---KEREKILEYKRQVQNLVNKSKK 444
+ L++I+ELE + ++ L+ +R +N K K+
Sbjct: 1107 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 103 bits (256), Expect = 3e-21
Identities = 155/753 (20%), Positives = 307/753 (40%), Gaps = 113/753 (15%)
Query: 653 KVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSV 712
+ ++T E+ T EL+ R Q +T+ L ++ SH ++ E++
Sbjct: 1156 EALKTELEDTLDSTATQQELRAKREQ------EVTVLKKALDEETRSHE--AQVQEMR-- 1205
Query: 713 QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
Q +QA+ E+ QL+ +K N+ Q LE N G L R
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDK-----NK-----QTLEKENADLAGEL------RV 1249
Query: 773 LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEA-YRCGLKKIKNDLNLKKSLL------ 825
L QA + E K EA++ E ++ C D ++ A + K++N++ +L
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 826 --------ATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFR 877
A++ ++LQ Q++ + ++Q L + E+ L D+ +D++++ +
Sbjct: 1310 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAK 1366
Query: 878 LWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEI 937
+LE+ I L N Q L D+K++ S RF E +NL +
Sbjct: 1367 Q-NLERHISTL-----NIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1415
Query: 938 SGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAA 997
K ++++K + D + L + + L K + + I + A
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475
Query: 998 D----VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCN 1053
D A E T++ R L E L++ E+L+ N ++ E+L ++D +N +
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 1054 K----NKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNE 1109
+ + L+ +++ + + + + +L + E+ K + E++ ++ K ++ E NE
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 1110 KITRLTY--------EIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE 1161
+ R E+EDE+++R + + D L+ L+++
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE--------------LQAD 1641
Query: 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENE-------LAKASNRIQESKNQCTQVVQERE 1214
AIK +E I++LR L + +RE E+ A A +++K+ ++Q +E
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1701
Query: 1215 SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSR 1274
L + +Q + L +EL + S A K+RLE Q++ +L + +
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761
Query: 1275 KEEAIRKI---------------------ESEREKSEREKNSLRSEIERLQAEIKRIEER 1313
+ +RK ES R++ ER+ LRS++ ++ +K +
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1821
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1346
LE + + Q+E E Q L+Q+
Sbjct: 1822 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Score = 94.0 bits (232), Expect = 2e-18
Identities = 139/713 (19%), Positives = 315/713 (44%), Gaps = 64/713 (8%)
Query: 743 QNEVFGLFQKL--ENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLD 800
QN +KL E I+ +T + L + + E M+ E RL +EE +
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1059
Query: 801 LDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKV 860
L+K++ +K++ D + +A ++ ++ ++ Q +++ L + +++
Sbjct: 1060 LEKLK------RKLEGDASDFHEQIADLQAQIA---ELKMQLAKKEEELQAALARLDDEI 1110
Query: 861 TQLTDRWQRIDKQIDFRLWDLEKQI-----------KQLRNYRDNYQAFCKWL---YDAK 906
Q + ++I ++++ + DL++ + KQ R+ + +A L D+
Sbjct: 1111 AQKNNALKKI-RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169
Query: 907 RRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966
Q L + + + + + L+E+ H E + + + Q + EL ++ ++ A
Sbjct: 1170 ATQQELRAKREQEVTVLKKALDEETRSH-EAQVQEMRQKHAQAVEEL-TEQLEQFKRAKA 1227
Query: 967 SYTSGLETL----LNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLK 1022
+ +TL ++ + ++ + + + A+ EL ++ D R +E+
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 1023 SLEDLKLKNTKIEVLEEE-----LRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
+ L+ + + + E ++LA+D S + ++ + + LQ+ + KL
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-SQLQDTQELLQEETRQKLNVSTKLR 1346
Query: 1078 SLEELKR--QAELDGK-SAKQNLDKCYGQI--------KELNEKITRLTYEIEDEKRRRK 1126
LEE + Q +LD + AKQNL++ + K+L + + + E +KR +K
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406
Query: 1127 SVED---RFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
+E+ +++++ YD+L+K + Q E ++L + + E + + LL E
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRA 1240
E +Y +E +A +E + + + + E L + LE+ L+ ++L +
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1526
Query: 1241 KSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEI 1300
K + LE K+ ++ + + KTQ E+ ++ E + + E +L+ +
Sbjct: 1527 KDDVGKNVH---ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 1301 ER-LQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREI-DKLRQRPYGSHRETQTEC 1358
ER LQA ++ EE+ RR+L+ E +++LE ER QR + +++ G ++ + +
Sbjct: 1584 ERDLQARDEQNEEK-RRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDLKDLELQA 1640
Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLID-KTTLDKLLKGKKSVEEVASEIQ 1410
+ + + LRK M+ ++ +L D + + D++ K E+ A ++
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693
Score = 77.8 bits (190), Expect = 1e-13
Identities = 104/496 (20%), Positives = 231/496 (46%), Gaps = 65/496 (13%)
Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQ 1060
A Y++L R+ ++R +++ K L + + +++ E+EL+ ++ + N+ K L+Q
Sbjct: 831 AAYLKL--RNWQWWRLFTKV-KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ 887
Query: 1061 NLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED 1120
+ E + + E+L+ + EL Y + +E+ ++ E+E+
Sbjct: 888 KHSQLTEEKNLLQ------EQLQAETEL------------YAEAEEMRVRLAAKKQELEE 929
Query: 1121 EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
+E R +++++ QLQ E++ + Q L+ E+ ++E+E ++L++
Sbjct: 930 ILHE---MEARLEEEEDRGQQLQ----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 982
Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKAR-LQRL----ED 1235
+ ++ E+E+ ++ + + ++++ER S L E++KA+ L +L E
Sbjct: 983 AEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041
Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
++ + L+ E + +Q LE K++++ D + + Q + + I +++ + K E E
Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE--- 1098
Query: 1296 LRSEIERLQAEIKRIEERCR--RKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRE 1353
L++ + RL EI + + R+LE + Q L++ER+ R + ++R G E
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA--ARNKAEKQKRDLGEELE 1156
Query: 1354 T-QTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKT------TLDKLLKGKKSVEEVA 1406
+TE E T+D++ + K+ + + + L ++T + K ++VEE+
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1216
Query: 1407 SEIQPFLRGAGSI-AGASASPKEKYSL-------------VEAKRKKLISPESTVMLLEA 1452
+++ F R ++ KE L VE K+KKL E+ V L++
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQS 1273
Query: 1453 QAATGGIIDPHRNEKL 1468
+ + G N+K+
Sbjct: 1274 KCSDGERARAELNDKV 1289
Score = 49.7 bits (117), Expect = 3e-05
Identities = 176/1017 (17%), Positives = 391/1017 (38%), Gaps = 117/1017 (11%)
Query: 197 QQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYE 256
+Q+ +++ V + +E I +N + R L++ +DL A + EE+ +
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--EEEEKAK 1030
Query: 257 NLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRM 316
NL K + + +L+ ++ + + + + L D SD + IA Q +
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK-LEGDASDFHEQIADLQAQIAELK 1089
Query: 317 SQLEVKEKELNKLKQESDQLVLNQHPASDKI---EAYMDTLQTQWSWILQITKCIDVHLK 373
QL KE+EL D + ++ A KI E ++ LQ
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD---------SERAA 1140
Query: 374 ENAAYFQFFEEAQSTEAYLKGLQDSI-----RKKYPCDKNMPLQHLLEQIKELEKEREKI 428
N A Q + + EA L+D++ +++ + + L + + E + E
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200
Query: 429 LEYKRQ--VQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKD 486
++ RQ Q + ++++ Q K + NK + + D + +++ + + +
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1257
Query: 487 NNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYY---EAILALWNQLYIN 543
+++ K ++ V + +L+ K+ + E++ + N+
Sbjct: 1258 EHKKKK--------LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 544 MKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDD 603
L D+ + + + +++E K +L E RNS ++ D+
Sbjct: 1310 AIKLAK------DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL--DE 1361
Query: 604 DKRKIQSQFTDAQKHYQTLVIQLPGYPQ--HQTVTTTEITHHGTCQDVNHNKVIE--TNR 659
+ Q+ ++H TL IQL + +T E G + K IE T +
Sbjct: 1362 EMEAKQN----LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR---FQKEIENLTQQ 1414
Query: 660 ENDKQETWMLMELQKIRRQ-------IEHCEGRMTLKNLPLADQGSSHHITVKIN-ELKS 711
+K + +E K R Q ++ R + NL + + + N K
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1474
Query: 712 VQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVR 771
+A AE + L+ R E E ++LE N + + L + +
Sbjct: 1475 ADERDRAEAEAREKETKALSLARALE-------EALEAKEELERTNKMLKAEMEDLVSSK 1527
Query: 772 ALL-QAILQTEDMLKVYEARLTEEETVCLDL-DKVEAYRCGLKKIKNDLN-LKKSLLATM 828
+ + + + E + E ++ E +T +L D+++A +++ ++ LK +
Sbjct: 1528 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1587
Query: 829 KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVT-------QLTDRWQRIDKQIDFRLWDL 881
+ ++ ++ Q +Q Y+ +L ++ +L + ++ Q D +
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1647
Query: 882 EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKR 941
E+ IKQLR + + F + L DA+ +D + + + + L +++
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA-- 1705
Query: 942 DKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHA 1001
+E +K A+L + + +LAS SG R +Q + A +
Sbjct: 1706 --AERARKQADLEKEELAE---ELASSLSG----------RNALQDEKRRLEARIAQLEE 1750
Query: 1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQN 1061
EL G+ + K+ + + + ++ + A + +NK L
Sbjct: 1751 ---ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807
Query: 1062 LQ--------KYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITR 1113
L K+++ + +AK+A LEE Q + ++A ++L K+ ++K+
Sbjct: 1808 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL-------KQKDKKLKE 1860
Query: 1114 LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYE 1170
+ ++EDE++ + +++ ++ QL+ RQ E+ Q++ + + ++E +
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLK--RQLEEAEEESQRINANRRKLQRELD 1915
Score = 35.8 bits (81), Expect = 0.49
Identities = 87/401 (21%), Positives = 165/401 (41%), Gaps = 68/401 (16%)
Query: 55 GYCQTGTMSRHQNQNTIQELLQ-NCSDCL-MRAELIVQPELKYGDGIQLTRSRE----LD 108
GY ++ Q Q T +++Q NC+ L +R + K +Q+TR E +
Sbjct: 806 GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 865
Query: 109 ECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRA-LYKAISVPRVRRASSK 167
+ + ++ + ++ ++E+ Q +K LLQ Q Q LY RVR A+ K
Sbjct: 866 DELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYAEAEEMRVRLAAKK 924
Query: 168 GGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNS 227
+ E + E R Q+ + + + +E+ +
Sbjct: 925 Q------ELEEILHEMEARLEEE---EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 228 IGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIN 287
+ QL+K+ A+ + K +LE+E + ++ + L + + +++ ++ N
Sbjct: 976 L-----QLEKVTAEAKIK----KLEDE----ILVMDDQNNKLSKERKLLEERISDLT-TN 1021
Query: 288 DCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLN-QHPASDK 346
EEEE K N+ + + +S+LEV+ K+ K +QE ++L + ASD
Sbjct: 1022 LAEEEE-------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 347 IEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCD 406
E D LQ Q + LK Q ++ + +A L L D I +K
Sbjct: 1075 HEQIAD-LQAQIA-----------ELK-----MQLAKKEEELQAALARLDDEIAQK---- 1113
Query: 407 KNMPLQHLLEQIKELE---KEREKILEYKRQVQNLVNKSKK 444
+ L++I+ELE + ++ L+ +R +N K K+
Sbjct: 1114 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 103 bits (256), Expect = 3e-21
Identities = 155/753 (20%), Positives = 307/753 (40%), Gaps = 113/753 (15%)
Query: 653 KVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSV 712
+ ++T E+ T EL+ R Q +T+ L ++ SH ++ E++
Sbjct: 1156 EALKTELEDTLDSTATQQELRAKREQ------EVTVLKKALDEETRSHE--AQVQEMR-- 1205
Query: 713 QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
Q +QA+ E+ QL+ +K N+ Q LE N G L R
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDK-----NK-----QTLEKENADLAGEL------RV 1249
Query: 773 LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEA-YRCGLKKIKNDLNLKKSLL------ 825
L QA + E K EA++ E ++ C D ++ A + K++N++ +L
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 826 --------ATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFR 877
A++ ++LQ Q++ + ++Q L + E+ L D+ +D++++ +
Sbjct: 1310 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAK 1366
Query: 878 LWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEI 937
+LE+ I L N Q L D+K++ S RF E +NL +
Sbjct: 1367 Q-NLERHISTL-----NIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1415
Query: 938 SGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAA 997
K ++++K + D + L + + L K + + I + A
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475
Query: 998 D----VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCN 1053
D A E T++ R L E L++ E+L+ N ++ E+L ++D +N +
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 1054 K----NKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNE 1109
+ + L+ +++ + + + + +L + E+ K + E++ ++ K ++ E NE
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 1110 KITRLTY--------EIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE 1161
+ R E+EDE+++R + + D L+ L+++
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE--------------LQAD 1641
Query: 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENE-------LAKASNRIQESKNQCTQVVQERE 1214
AIK +E I++LR L + +RE E+ A A +++K+ ++Q +E
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1701
Query: 1215 SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSR 1274
L + +Q + L +EL + S A K+RLE Q++ +L + +
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761
Query: 1275 KEEAIRKI---------------------ESEREKSEREKNSLRSEIERLQAEIKRIEER 1313
+ +RK ES R++ ER+ LRS++ ++ +K +
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1821
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1346
LE + + Q+E E Q L+Q+
Sbjct: 1822 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Score = 94.0 bits (232), Expect = 2e-18
Identities = 139/713 (19%), Positives = 315/713 (44%), Gaps = 64/713 (8%)
Query: 743 QNEVFGLFQKL--ENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLD 800
QN +KL E I+ +T + L + + E M+ E RL +EE +
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1059
Query: 801 LDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKV 860
L+K++ +K++ D + +A ++ ++ ++ Q +++ L + +++
Sbjct: 1060 LEKLK------RKLEGDASDFHEQIADLQAQIA---ELKMQLAKKEEELQAALARLDDEI 1110
Query: 861 TQLTDRWQRIDKQIDFRLWDLEKQI-----------KQLRNYRDNYQAFCKWL---YDAK 906
Q + ++I ++++ + DL++ + KQ R+ + +A L D+
Sbjct: 1111 AQKNNALKKI-RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169
Query: 907 RRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966
Q L + + + + + L+E+ H E + + + Q + EL ++ ++ A
Sbjct: 1170 ATQQELRAKREQEVTVLKKALDEETRSH-EAQVQEMRQKHAQAVEEL-TEQLEQFKRAKA 1227
Query: 967 SYTSGLETL----LNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLK 1022
+ +TL ++ + ++ + + + A+ EL ++ D R +E+
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 1023 SLEDLKLKNTKIEVLEEE-----LRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
+ L+ + + + E ++LA+D S + ++ + + LQ+ + KL
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-SQLQDTQELLQEETRQKLNVSTKLR 1346
Query: 1078 SLEELKR--QAELDGK-SAKQNLDKCYGQI--------KELNEKITRLTYEIEDEKRRRK 1126
LEE + Q +LD + AKQNL++ + K+L + + + E +KR +K
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406
Query: 1127 SVED---RFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
+E+ +++++ YD+L+K + Q E ++L + + E + + LL E
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRA 1240
E +Y +E +A +E + + + + E L + LE+ L+ ++L +
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1526
Query: 1241 KSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEI 1300
K + LE K+ ++ + + KTQ E+ ++ E + + E +L+ +
Sbjct: 1527 KDDVGKNVH---ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 1301 ER-LQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREI-DKLRQRPYGSHRETQTEC 1358
ER LQA ++ EE+ RR+L+ E +++LE ER QR + +++ G ++ + +
Sbjct: 1584 ERDLQARDEQNEEK-RRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDLKDLELQA 1640
Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLID-KTTLDKLLKGKKSVEEVASEIQ 1410
+ + + LRK M+ ++ +L D + + D++ K E+ A ++
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693
Score = 77.8 bits (190), Expect = 1e-13
Identities = 104/496 (20%), Positives = 231/496 (46%), Gaps = 65/496 (13%)
Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQ 1060
A Y++L R+ ++R +++ K L + + +++ E+EL+ ++ + N+ K L+Q
Sbjct: 831 AAYLKL--RNWQWWRLFTKV-KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ 887
Query: 1061 NLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED 1120
+ E + + E+L+ + EL Y + +E+ ++ E+E+
Sbjct: 888 KHSQLTEEKNLLQ------EQLQAETEL------------YAEAEEMRVRLAAKKQELEE 929
Query: 1121 EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
+E R +++++ QLQ E++ + Q L+ E+ ++E+E ++L++
Sbjct: 930 ILHE---MEARLEEEEDRGQQLQ----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 982
Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKAR-LQRL----ED 1235
+ ++ E+E+ ++ + + ++++ER S L E++KA+ L +L E
Sbjct: 983 AEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041
Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
++ + L+ E + +Q LE K++++ D + + Q + + I +++ + K E E
Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE--- 1098
Query: 1296 LRSEIERLQAEIKRIEERCR--RKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRE 1353
L++ + RL EI + + R+LE + Q L++ER+ R + ++R G E
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA--ARNKAEKQKRDLGEELE 1156
Query: 1354 T-QTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKT------TLDKLLKGKKSVEEVA 1406
+TE E T+D++ + K+ + + + L ++T + K ++VEE+
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1216
Query: 1407 SEIQPFLRGAGSI-AGASASPKEKYSL-------------VEAKRKKLISPESTVMLLEA 1452
+++ F R ++ KE L VE K+KKL E+ V L++
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQS 1273
Query: 1453 QAATGGIIDPHRNEKL 1468
+ + G N+K+
Sbjct: 1274 KCSDGERARAELNDKV 1289
Score = 49.7 bits (117), Expect = 3e-05
Identities = 176/1017 (17%), Positives = 391/1017 (38%), Gaps = 117/1017 (11%)
Query: 197 QQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYE 256
+Q+ +++ V + +E I +N + R L++ +DL A + EE+ +
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--EEEEKAK 1030
Query: 257 NLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRM 316
NL K + + +L+ ++ + + + + L D SD + IA Q +
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK-LEGDASDFHEQIADLQAQIAELK 1089
Query: 317 SQLEVKEKELNKLKQESDQLVLNQHPASDKI---EAYMDTLQTQWSWILQITKCIDVHLK 373
QL KE+EL D + ++ A KI E ++ LQ
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD---------SERAA 1140
Query: 374 ENAAYFQFFEEAQSTEAYLKGLQDSI-----RKKYPCDKNMPLQHLLEQIKELEKEREKI 428
N A Q + + EA L+D++ +++ + + L + + E + E
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200
Query: 429 LEYKRQ--VQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKD 486
++ RQ Q + ++++ Q K + NK + + D + +++ + + +
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1257
Query: 487 NNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYY---EAILALWNQLYIN 543
+++ K ++ V + +L+ K+ + E++ + N+
Sbjct: 1258 EHKKKK--------LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 544 MKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDD 603
L D+ + + + +++E K +L E RNS ++ D+
Sbjct: 1310 AIKLAK------DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL--DE 1361
Query: 604 DKRKIQSQFTDAQKHYQTLVIQLPGYPQ--HQTVTTTEITHHGTCQDVNHNKVIE--TNR 659
+ Q+ ++H TL IQL + +T E G + K IE T +
Sbjct: 1362 EMEAKQN----LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR---FQKEIENLTQQ 1414
Query: 660 ENDKQETWMLMELQKIRRQ-------IEHCEGRMTLKNLPLADQGSSHHITVKIN-ELKS 711
+K + +E K R Q ++ R + NL + + + N K
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1474
Query: 712 VQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVR 771
+A AE + L+ R E E ++LE N + + L + +
Sbjct: 1475 ADERDRAEAEAREKETKALSLARALE-------EALEAKEELERTNKMLKAEMEDLVSSK 1527
Query: 772 ALL-QAILQTEDMLKVYEARLTEEETVCLDL-DKVEAYRCGLKKIKNDLN-LKKSLLATM 828
+ + + + E + E ++ E +T +L D+++A +++ ++ LK +
Sbjct: 1528 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1587
Query: 829 KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVT-------QLTDRWQRIDKQIDFRLWDL 881
+ ++ ++ Q +Q Y+ +L ++ +L + ++ Q D +
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1647
Query: 882 EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKR 941
E+ IKQLR + + F + L DA+ +D + + + + L +++
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA-- 1705
Query: 942 DKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHA 1001
+E +K A+L + + +LAS SG R +Q + A +
Sbjct: 1706 --AERARKQADLEKEELAE---ELASSLSG----------RNALQDEKRRLEARIAQLEE 1750
Query: 1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQN 1061
EL G+ + K+ + + + ++ + A + +NK L
Sbjct: 1751 ---ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807
Query: 1062 LQ--------KYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITR 1113
L K+++ + +AK+A LEE Q + ++A ++L K+ ++K+
Sbjct: 1808 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL-------KQKDKKLKE 1860
Query: 1114 LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYE 1170
+ ++EDE++ + +++ ++ QL+ RQ E+ Q++ + + ++E +
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLK--RQLEEAEEESQRINANRRKLQRELD 1915
Score = 35.8 bits (81), Expect = 0.49
Identities = 87/401 (21%), Positives = 165/401 (41%), Gaps = 68/401 (16%)
Query: 55 GYCQTGTMSRHQNQNTIQELLQ-NCSDCL-MRAELIVQPELKYGDGIQLTRSRE----LD 108
GY ++ Q Q T +++Q NC+ L +R + K +Q+TR E +
Sbjct: 806 GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 865
Query: 109 ECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRA-LYKAISVPRVRRASSK 167
+ + ++ + ++ ++E+ Q +K LLQ Q Q LY RVR A+ K
Sbjct: 866 DELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYAEAEEMRVRLAAKK 924
Query: 168 GGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNS 227
+ E + E R Q+ + + + +E+ +
Sbjct: 925 Q------ELEEILHEMEARLEEE---EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 228 IGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIN 287
+ QL+K+ A+ + K +LE+E + ++ + L + + +++ ++ N
Sbjct: 976 L-----QLEKVTAEAKIK----KLEDE----ILVMDDQNNKLSKERKLLEERISDLT-TN 1021
Query: 288 DCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLN-QHPASDK 346
EEEE K N+ + + +S+LEV+ K+ K +QE ++L + ASD
Sbjct: 1022 LAEEEE-------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 347 IEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCD 406
E D LQ Q + LK Q ++ + +A L L D I +K
Sbjct: 1075 HEQIAD-LQAQIA-----------ELK-----MQLAKKEEELQAALARLDDEIAQK---- 1113
Query: 407 KNMPLQHLLEQIKELE---KEREKILEYKRQVQNLVNKSKK 444
+ L++I+ELE + ++ L+ +R +N K K+
Sbjct: 1114 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 103 bits (256), Expect = 3e-21
Identities = 155/753 (20%), Positives = 307/753 (40%), Gaps = 113/753 (15%)
Query: 653 KVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSV 712
+ ++T E+ T EL+ R Q +T+ L ++ SH ++ E++
Sbjct: 1149 EALKTELEDTLDSTATQQELRAKREQ------EVTVLKKALDEETRSHE--AQVQEMR-- 1198
Query: 713 QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
Q +QA+ E+ QL+ +K N+ Q LE N G L R
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDK-----NK-----QTLEKENADLAGEL------RV 1242
Query: 773 LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEA-YRCGLKKIKNDLNLKKSLL------ 825
L QA + E K EA++ E ++ C D ++ A + K++N++ +L
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 826 --------ATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFR 877
A++ ++LQ Q++ + ++Q L + E+ L D+ +D++++ +
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAK 1359
Query: 878 LWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEI 937
+LE+ I L N Q L D+K++ S RF E +NL +
Sbjct: 1360 Q-NLERHISTL-----NIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1408
Query: 938 SGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAA 997
K ++++K + D + L + + L K + + I + A
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468
Query: 998 D----VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCN 1053
D A E T++ R L E L++ E+L+ N ++ E+L ++D +N +
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 1054 K----NKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNE 1109
+ + L+ +++ + + + + +L + E+ K + E++ ++ K ++ E NE
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 1110 KITRLTY--------EIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE 1161
+ R E+EDE+++R + + D L+ L+++
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE--------------LQAD 1634
Query: 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENE-------LAKASNRIQESKNQCTQVVQERE 1214
AIK +E I++LR L + +RE E+ A A +++K+ ++Q +E
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1694
Query: 1215 SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSR 1274
L + +Q + L +EL + S A K+RLE Q++ +L + +
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 1275 KEEAIRKI---------------------ESEREKSEREKNSLRSEIERLQAEIKRIEER 1313
+ +RK ES R++ ER+ LRS++ ++ +K +
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1814
Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1346
LE + + Q+E E Q L+Q+
Sbjct: 1815 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847
Score = 94.0 bits (232), Expect = 2e-18
Identities = 139/713 (19%), Positives = 315/713 (44%), Gaps = 64/713 (8%)
Query: 743 QNEVFGLFQKL--ENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLD 800
QN +KL E I+ +T + L + + E M+ E RL +EE +
Sbjct: 993 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1052
Query: 801 LDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKV 860
L+K++ +K++ D + +A ++ ++ ++ Q +++ L + +++
Sbjct: 1053 LEKLK------RKLEGDASDFHEQIADLQAQIA---ELKMQLAKKEEELQAALARLDDEI 1103
Query: 861 TQLTDRWQRIDKQIDFRLWDLEKQI-----------KQLRNYRDNYQAFCKWL---YDAK 906
Q + ++I ++++ + DL++ + KQ R+ + +A L D+
Sbjct: 1104 AQKNNALKKI-RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162
Query: 907 RRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966
Q L + + + + + L+E+ H E + + + Q + EL ++ ++ A
Sbjct: 1163 ATQQELRAKREQEVTVLKKALDEETRSH-EAQVQEMRQKHAQAVEEL-TEQLEQFKRAKA 1220
Query: 967 SYTSGLETL----LNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLK 1022
+ +TL ++ + ++ + + + A+ EL ++ D R +E+
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 1023 SLEDLKLKNTKIEVLEEE-----LRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
+ L+ + + + E ++LA+D S + ++ + + LQ+ + KL
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-SQLQDTQELLQEETRQKLNVSTKLR 1339
Query: 1078 SLEELKR--QAELDGK-SAKQNLDKCYGQI--------KELNEKITRLTYEIEDEKRRRK 1126
LEE + Q +LD + AKQNL++ + K+L + + + E +KR +K
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1399
Query: 1127 SVED---RFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
+E+ +++++ YD+L+K + Q E ++L + + E + + LL E
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459
Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRA 1240
E +Y +E +A +E + + + + E L + LE+ L+ ++L +
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519
Query: 1241 KSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEI 1300
K + LE K+ ++ + + KTQ E+ ++ E + + E +L+ +
Sbjct: 1520 KDDVGKNVH---ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Query: 1301 ER-LQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREI-DKLRQRPYGSHRETQTEC 1358
ER LQA ++ EE+ RR+L+ E +++LE ER QR + +++ G ++ + +
Sbjct: 1577 ERDLQARDEQNEEK-RRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDLKDLELQA 1633
Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLID-KTTLDKLLKGKKSVEEVASEIQ 1410
+ + + LRK M+ ++ +L D + + D++ K E+ A ++
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686
Score = 77.8 bits (190), Expect = 1e-13
Identities = 104/496 (20%), Positives = 231/496 (46%), Gaps = 65/496 (13%)
Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQ 1060
A Y++L R+ ++R +++ K L + + +++ E+EL+ ++ + N+ K L+Q
Sbjct: 824 AAYLKL--RNWQWWRLFTKV-KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ 880
Query: 1061 NLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED 1120
+ E + + E+L+ + EL Y + +E+ ++ E+E+
Sbjct: 881 KHSQLTEEKNLLQ------EQLQAETEL------------YAEAEEMRVRLAAKKQELEE 922
Query: 1121 EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
+E R +++++ QLQ E++ + Q L+ E+ ++E+E ++L++
Sbjct: 923 ILHE---MEARLEEEEDRGQQLQ----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 975
Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKAR-LQRL----ED 1235
+ ++ E+E+ ++ + + ++++ER S L E++KA+ L +L E
Sbjct: 976 AEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1034
Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
++ + L+ E + +Q LE K++++ D + + Q + + I +++ + K E E
Sbjct: 1035 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE--- 1091
Query: 1296 LRSEIERLQAEIKRIEERCR--RKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRE 1353
L++ + RL EI + + R+LE + Q L++ER+ R + ++R G E
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA--ARNKAEKQKRDLGEELE 1149
Query: 1354 T-QTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKT------TLDKLLKGKKSVEEVA 1406
+TE E T+D++ + K+ + + + L ++T + K ++VEE+
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1209
Query: 1407 SEIQPFLRGAGSI-AGASASPKEKYSL-------------VEAKRKKLISPESTVMLLEA 1452
+++ F R ++ KE L VE K+KKL E+ V L++
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQS 1266
Query: 1453 QAATGGIIDPHRNEKL 1468
+ + G N+K+
Sbjct: 1267 KCSDGERARAELNDKV 1282
Score = 49.7 bits (117), Expect = 3e-05
Identities = 176/1017 (17%), Positives = 391/1017 (38%), Gaps = 117/1017 (11%)
Query: 197 QQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYE 256
+Q+ +++ V + +E I +N + R L++ +DL A + EE+ +
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--EEEEKAK 1023
Query: 257 NLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRM 316
NL K + + +L+ ++ + + + + L D SD + IA Q +
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK-LEGDASDFHEQIADLQAQIAELK 1082
Query: 317 SQLEVKEKELNKLKQESDQLVLNQHPASDKI---EAYMDTLQTQWSWILQITKCIDVHLK 373
QL KE+EL D + ++ A KI E ++ LQ
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD---------SERAA 1133
Query: 374 ENAAYFQFFEEAQSTEAYLKGLQDSI-----RKKYPCDKNMPLQHLLEQIKELEKEREKI 428
N A Q + + EA L+D++ +++ + + L + + E + E
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193
Query: 429 LEYKRQ--VQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKD 486
++ RQ Q + ++++ Q K + NK + + D + +++ + + +
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1250
Query: 487 NNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYY---EAILALWNQLYIN 543
+++ K ++ V + +L+ K+ + E++ + N+
Sbjct: 1251 EHKKKK--------LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 544 MKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDD 603
L D+ + + + +++E K +L E RNS ++ D+
Sbjct: 1303 AIKLAK------DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL--DE 1354
Query: 604 DKRKIQSQFTDAQKHYQTLVIQLPGYPQ--HQTVTTTEITHHGTCQDVNHNKVIE--TNR 659
+ Q+ ++H TL IQL + +T E G + K IE T +
Sbjct: 1355 EMEAKQN----LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR---FQKEIENLTQQ 1407
Query: 660 ENDKQETWMLMELQKIRRQ-------IEHCEGRMTLKNLPLADQGSSHHITVKIN-ELKS 711
+K + +E K R Q ++ R + NL + + + N K
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1467
Query: 712 VQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVR 771
+A AE + L+ R E E ++LE N + + L + +
Sbjct: 1468 ADERDRAEAEAREKETKALSLARALE-------EALEAKEELERTNKMLKAEMEDLVSSK 1520
Query: 772 ALL-QAILQTEDMLKVYEARLTEEETVCLDL-DKVEAYRCGLKKIKNDLN-LKKSLLATM 828
+ + + + E + E ++ E +T +L D+++A +++ ++ LK +
Sbjct: 1521 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1580
Query: 829 KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVT-------QLTDRWQRIDKQIDFRLWDL 881
+ ++ ++ Q +Q Y+ +L ++ +L + ++ Q D +
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1640
Query: 882 EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKR 941
E+ IKQLR + + F + L DA+ +D + + + + L +++
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA-- 1698
Query: 942 DKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHA 1001
+E +K A+L + + +LAS SG R +Q + A +
Sbjct: 1699 --AERARKQADLEKEELAE---ELASSLSG----------RNALQDEKRRLEARIAQLEE 1743
Query: 1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQN 1061
EL G+ + K+ + + + ++ + A + +NK L
Sbjct: 1744 ---ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800
Query: 1062 LQ--------KYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITR 1113
L K+++ + +AK+A LEE Q + ++A ++L K+ ++K+
Sbjct: 1801 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL-------KQKDKKLKE 1853
Query: 1114 LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYE 1170
+ ++EDE++ + +++ ++ QL+ RQ E+ Q++ + + ++E +
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLK--RQLEEAEEESQRINANRRKLQRELD 1908
Score = 35.8 bits (81), Expect = 0.49
Identities = 87/401 (21%), Positives = 165/401 (41%), Gaps = 68/401 (16%)
Query: 55 GYCQTGTMSRHQNQNTIQELLQ-NCSDCL-MRAELIVQPELKYGDGIQLTRSRE----LD 108
GY ++ Q Q T +++Q NC+ L +R + K +Q+TR E +
Sbjct: 799 GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 858
Query: 109 ECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRA-LYKAISVPRVRRASSK 167
+ + ++ + ++ ++E+ Q +K LLQ Q Q LY RVR A+ K
Sbjct: 859 DELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYAEAEEMRVRLAAKK 917
Query: 168 GGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNS 227
+ E + E R Q+ + + + +E+ +
Sbjct: 918 Q------ELEEILHEMEARLEEE---EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 228 IGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIN 287
+ QL+K+ A+ + K +LE+E + ++ + L + + +++ ++ N
Sbjct: 969 L-----QLEKVTAEAKIK----KLEDE----ILVMDDQNNKLSKERKLLEERISDLT-TN 1014
Query: 288 DCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLN-QHPASDK 346
EEEE K N+ + + +S+LEV+ K+ K +QE ++L + ASD
Sbjct: 1015 LAEEEE-------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 347 IEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCD 406
E D LQ Q + LK Q ++ + +A L L D I +K
Sbjct: 1068 HEQIAD-LQAQIA-----------ELK-----MQLAKKEEELQAALARLDDEIAQK---- 1106
Query: 407 KNMPLQHLLEQIKELE---KEREKILEYKRQVQNLVNKSKK 444
+ L++I+ELE + ++ L+ +R +N K K+
Sbjct: 1107 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 102 bits (255), Expect = 3e-21
Identities = 188/974 (19%), Positives = 387/974 (39%), Gaps = 135/974 (13%)
Query: 520 VDLSCKIEQYYEAILAL--WNQLYINMKSLVSWHYC----MIDIEKIRAMTIAKLKTMRQ 573
V KI++ E IL L N +I K L+ + E+ +A +AK++ ++
Sbjct: 974 VTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQE 1033
Query: 574 EDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQ 633
I+DLE E ++ + + + KRK+ + TD Q L Q+
Sbjct: 1034 V----MISDLE----ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQL 1085
Query: 634 TVTTTEITH---HGTCQDVNHNKVIETNRENDKQ----------ETWMLMELQKIRRQI- 679
E+ G + ++ N ++ RE Q E + +K +R +
Sbjct: 1086 AKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145
Query: 680 EHCEGRMTLKNLPLADQGSSHHITVK----INELKSVQNDSQAIAEVLNQLKDMLANFRG 735
E E T L + + K + ELK + E Q++DM
Sbjct: 1146 EELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEA--QIQDMRQRHAT 1203
Query: 736 SEKYCYLQNEVFGLFQ-KLE-NINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTE 793
+ + Q E F+ LE N G+ C V+ L Q ++E K +A++ E
Sbjct: 1204 ALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQE 1263
Query: 794 EETVCLDLDKVEAYRCG-LKKIKNDLNLKKSLLATM-KTELQKAQQIHSQTSQQYPLYDL 851
+ D++ K++N+L+ +LL K ++ A+ S SQ +L
Sbjct: 1264 LHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQEL 1323
Query: 852 DLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDS 911
+ +K+ L+ R ++++++ + E++ + +N A L D K++ D
Sbjct: 1324 LQEETRQKLN-LSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382
Query: 912 LESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSG 971
D T+ +K L + + EE + + + +L T
Sbjct: 1383 -------DLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVD 1435
Query: 972 LETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL-----------TRSGDYYRFLSEM 1020
L+ + Q +L E + ARY E T++ R L E
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEA 1495
Query: 1021 LKSLEDLKLKNTKIEVLEEELRLARDANSENCNK----NKFLDQNLQKYQAECSQFKAKL 1076
L++ E+ + +N ++ E+L ++D +N ++ + L+Q +++ + + + + +L
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555
Query: 1077 ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTY--------EIEDEKRRR--- 1125
+ E+ K + E++ ++ K ++ E NE+ RL E+EDE+++R
Sbjct: 1556 QATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALA 1615
Query: 1126 -----------KSVEDRFDQ-----------------QKNDYDQLQKARQCEKENLGWQK 1157
K +E + + Q DY + + + ++ + Q
Sbjct: 1616 VASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQS 1675
Query: 1158 LESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLL 1217
ESEK +K E EI +L+ L +R E E + ++ I S + + ++ E+ L
Sbjct: 1676 KESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLE 1735
Query: 1218 VKI----KVLEQDKARLQRLED--------------ELNRAKSTLEAETRVKQRLECEKQ 1259
+I + LE++++ ++ L D EL +S + +Q+LE + +
Sbjct: 1736 ARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNK 1795
Query: 1260 QIQNDL--------NQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRI- 1310
+++ L +++K S E I ++E + E+ +E+ + + R + ++K I
Sbjct: 1796 ELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIF 1855
Query: 1311 -EERCRRKLEDSTRETQSQLETERSRYQREIDKLRQ---RPYGSHRETQTECEWTVDTSK 1366
+ R+ D +E + + +R++++ + R S R+ Q E +D +
Sbjct: 1856 MQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRE----LDDAT 1911
Query: 1367 LVFDGLRKKVTAMQ 1380
+GL ++V+ ++
Sbjct: 1912 EANEGLSREVSTLK 1925
Score = 85.5 bits (210), Expect = 5e-16
Identities = 142/686 (20%), Positives = 282/686 (41%), Gaps = 122/686 (17%)
Query: 876 FRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHS 935
+R++ K + Q+ + QA + L K +Q +E L E + H
Sbjct: 835 WRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGE-----------LEEMERKHQ 883
Query: 936 EISGKRD-KSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQ 994
++ +++ +E++Q EL A + ++ +LA+ LE +L+ R + ILQ
Sbjct: 884 QLLEEKNILAEQLQAETELFAEA-EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQ 942
Query: 995 EAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNK 1054
+I+ L D + L+ LE + + KI+ +EEE+ L D NS+ +
Sbjct: 943 NEKKKMQAHIQDLEEQLDEEEGARQKLQ-LEKVTAE-AKIKKMEEEILLLEDQNSKFIKE 1000
Query: 1055 NKFLDQNLQKYQAECSQFKAKLASLEELKRQAEL----------DGKSAKQNLDKCY--- 1101
K ++ + + ++ ++ + K +L +++ + E+ + +Q L+K
Sbjct: 1001 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060
Query: 1102 -GQIKELNEKITRLTYEIEDEKRRRKSVEDRF--------DQQKNDYDQLQKARQCEKEN 1152
G+ +L ++I L +I++ K + E+ D+ + + L+ R+ + +
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQI 1120
Query: 1153 LGWQK-LESEKAIKEK--------EYEIERLRVLL---------QEEGTRKREYE-NELA 1193
Q+ ESEKA + K E+E L+ L Q+E KRE E EL
Sbjct: 1121 AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK 1180
Query: 1194 KASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQR 1253
KA +E+KN Q+ R+ ++ L + + +R + L + K LE + +
Sbjct: 1181 KALE--EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK---E 1235
Query: 1254 LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE-- 1311
L CE + +Q + + + + + ++++ ++ + +R + L + +LQ E+ +
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295
Query: 1312 -ERCRRK----------LEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEW 1360
E +K LE ++TQ L+ E + ++RQ E + +
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQL-----EEEKNSLQE 1350
Query: 1361 TVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIA 1420
+ + L K+V A+Q +L KK V++ I+
Sbjct: 1351 QQEEEEEARKNLEKQVLALQ------------SQLADTKKKVDDDLGTIE---------- 1388
Query: 1421 GASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRN------EKLTVDSAI 1474
SL EAK+K L E+ LE +A ++ +N + LTVD
Sbjct: 1389 ----------SLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH 1438
Query: 1475 ARDLIDFDDRQ-----QIYAAEKAIT 1495
R + +++ Q+ A EK+I+
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSIS 1464
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 99.0 bits (245), Expect = 5e-20
Identities = 154/743 (20%), Positives = 305/743 (41%), Gaps = 98/743 (13%)
Query: 709 LKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENING---VTDGYLN 765
L+ + ++Q + L +K +L +G + L+ +V L KL+++ G + L
Sbjct: 410 LERRKGEAQQSNKELQNMKRLLD--QGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLK 467
Query: 766 SLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLL 825
L R LL+ +L+ + ++ + RL E E L E +++++ +
Sbjct: 468 DLLETRELLEEVLEGKQRVEE-QLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDT 526
Query: 826 ATMKTELQKAQQIHSQTS---QQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLE 882
++ +Q A Q H+ Q+ L + E+ ++ T WQ + ++ L +
Sbjct: 527 EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATK 586
Query: 883 KQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTV-------MRFLNEQKNLHS 935
+++ QLR ++ + + +R+ GD+ V +R E K L +
Sbjct: 587 QELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQA 646
Query: 936 E-----ISGKRDKSEEVQKIAELCANS-----IKDYELQLASYTSGLETLLNIPIKRTMI 985
E ++G+ E +++A L + +++ LQL L K M+
Sbjct: 647 ERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMV 706
Query: 986 QSPSGVIL-QEAADVHARYIELLTRSGDYYRFLSEMLKSLED--------------LKLK 1030
+L Q A V E + ++ R + + + L++ L+ K
Sbjct: 707 AEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDK 766
Query: 1031 NTKIEVLEEELRLARDANSENCNK-----------------------------NKFLDQN 1061
++E +++L A +A+ E N+ L++
Sbjct: 767 LQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEE 826
Query: 1062 ------LQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
L++ +AE + K L +++ L ++ E G+ +KQ L + Q+++ EK R
Sbjct: 827 GKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARR- 885
Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERL 1174
E+ D +R+ K ++ +LQ Q ++ L + E + A +KE +RL
Sbjct: 886 --EVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRL 943
Query: 1175 RVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLE 1234
+ L QE +KR ++ + ++ T++ +E+ ++ E R+ R
Sbjct: 944 QGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTV-------ELLTDRVNRGR 996
Query: 1235 DELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKN 1294
D++++ ++ L E +Q LEC+K ++ KT+ + E +K + + E +
Sbjct: 997 DQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLA-SSEGFQKPSASLSQLESQNQ 1055
Query: 1295 SLRSEIERLQAEI--KRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHR 1352
L+ ERLQAE K + + RKLE +E Q+E ER + D+L R R
Sbjct: 1056 LLQ---ERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKR 1112
Query: 1353 ETQTECEWTVDTSKLVFDGLRKK 1375
+ E E ++ DGLRKK
Sbjct: 1113 QVD-EAEEEIER----LDGLRKK 1130
Score = 98.2 bits (243), Expect = 8e-20
Identities = 138/598 (23%), Positives = 257/598 (42%), Gaps = 65/598 (10%)
Query: 770 VRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLN--LKKSLLAT 827
V L + +L+T++ LK +A +E D+ + + +++ D L++ L
Sbjct: 627 VEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQL 686
Query: 828 MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDF---RLWDLEKQ 884
KT LQ+ +Q + S+ + + + G++ + + ++ D R+ LE+Q
Sbjct: 687 QKT-LQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQ 745
Query: 885 IKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKS 944
+K+ R D +A L D +R ++ E++ L ++ +++
Sbjct: 746 LKETRGLVDGGEAVEARLRDKLQRLEA-----------------EKQQLEEALNASQEEE 788
Query: 945 EEVQKIAELCANSIKDYELQLASYTSGLETL---LNIPIKRTMIQSPSGVILQEAADVHA 1001
+ +++ + LA +TL L K+ + L+E +
Sbjct: 789 GSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLD 848
Query: 1002 RYIELLTRS-----GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN- 1055
R ++ L + D + L ++ LED K K + EV + + R A+D SE +
Sbjct: 849 RTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARR-EVADAQ-RQAKDWASEAEKTSG 906
Query: 1056 ---------KFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKE 1106
+ L Q LQ QAE + L + + E + ++ K++ D Q+K
Sbjct: 907 GLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKG 966
Query: 1107 LNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKE 1166
L EK++RL E+++EK + + DR ++ ++ DQL+ + +E Q LE +K E
Sbjct: 967 LEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLR--TELMQERSARQDLECDKISLE 1024
Query: 1167 KEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQD 1226
++ + + R L EG +K AS ES+N Q++QER ++ E++
Sbjct: 1025 RQNKDLKTR-LASSEGFQK-------PSASLSQLESQN---QLLQER------LQAEERE 1067
Query: 1227 KARLQRLEDELNRAKSTLEAETR-VKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESE 1285
K LQ +L R L + +Q + +K Q+ + K Q EE I +++
Sbjct: 1068 KTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGL 1127
Query: 1286 REKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKL 1343
R+K++RE E+LQA IK +E+ RK S E S L+ E E D +
Sbjct: 1128 RKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAE--SALKNEGLSSDEEFDSV 1183
Score = 64.3 bits (155), Expect = 1e-09
Identities = 89/457 (19%), Positives = 196/457 (42%), Gaps = 55/457 (12%)
Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECS 1070
G+ R + E+ + L++ K K+E + L + +E C++ L + L++ + E
Sbjct: 362 GELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSR---LQELLERRKGEAQ 418
Query: 1071 QFKAKLASLEELKRQA------------ELDGK--------SAKQNLDKCYGQIKELNEK 1110
Q +L +++ L Q EL K AK+ L K + +EL E+
Sbjct: 419 QSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEE 478
Query: 1111 ITRLTYEIEDEKRRRK--------SVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEK 1162
+ +E++ R R+ ++++ + + + +++ Q + E L ++ +
Sbjct: 479 VLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQ 538
Query: 1163 AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKV 1222
E E +++ L++ E E + Q++K QE L ++ +
Sbjct: 539 DHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEE 598
Query: 1223 LEQDKA-RLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRK 1281
+E++ +++ L+ EL +A+++ +TR + L+ E + Q +L + + + +E A R
Sbjct: 599 MEEELGEKIEVLQRELEQARAS-AGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRH 657
Query: 1282 IESEREKS---EREKNSLRSEIERLQAEIKRIEERCRRKLEDSTR-------------ET 1325
+ E EK R + E+E ++++ ++ R+ E++++ +
Sbjct: 658 RDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQR 717
Query: 1326 QSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQ 1385
++ +ET Q E D+ R+R G ++ + E VD + V LR K+ ++ + Q
Sbjct: 718 RAAVETTLRETQEENDEFRRRILGLEQQLK-ETRGLVDGGEAVEARLRDKLQRLEAEKQQ 776
Query: 1386 LIDKTTLDK-----LLKGKKSVEEVASEIQPFLRGAG 1417
L + + L K+++E E Q L G
Sbjct: 777 LEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLG 813
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,655,462
Number of Sequences: 37866
Number of extensions: 3612930
Number of successful extensions: 31198
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 473
Number of HSP's successfully gapped in prelim test: 1042
Number of HSP's that attempted gapping in prelim test: 13394
Number of HSP's gapped (non-prelim): 8657
length of query: 2272
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2154
effective length of database: 13,779,330
effective search space: 29680676820
effective search space used: 29680676820
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.