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Search of human proteins with 57242757
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|57242757 calsyntenin 1 isoform 1 [Homo sapiens]
(981 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|57242757 calsyntenin 1 isoform 1 [Homo sapiens] 2006 0.0
gi|57242755 calsyntenin 1 isoform 2 [Homo sapiens] 1980 0.0
gi|209364544 calsyntenin 2 [Homo sapiens] 1099 0.0
gi|42475534 calsyntenin 3 [Homo sapiens] 1016 0.0
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 66 1e-10
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 63 1e-09
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 62 2e-09
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 62 2e-09
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens] 62 2e-09
gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo ... 62 2e-09
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 61 6e-09
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 59 3e-08
gi|11276081 protocadherin beta 8 precursor [Homo sapiens] 59 3e-08
gi|157426847 protocadherin 19 isoform a [Homo sapiens] 57 6e-08
gi|157426845 protocadherin 19 isoform b [Homo sapiens] 57 6e-08
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 57 6e-08
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 55 4e-07
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 55 4e-07
gi|14270508 protocadherin gamma subfamily B, 7 isoform 2 precurs... 54 5e-07
gi|11128027 protocadherin gamma subfamily B, 7 isoform 1 precurs... 54 5e-07
gi|11128029 protocadherin gamma subfamily B, 6 isoform 1 precurs... 54 9e-07
gi|14270502 protocadherin gamma subfamily B, 6 isoform 2 precurs... 54 9e-07
gi|11036654 protocadherin beta 13 precursor [Homo sapiens] 54 9e-07
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 53 1e-06
gi|17975763 myelin transcription factor 1 [Homo sapiens] 53 1e-06
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens] 53 2e-06
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 52 2e-06
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 52 2e-06
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 52 2e-06
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 52 2e-06
>gi|57242757 calsyntenin 1 isoform 1 [Homo sapiens]
Length = 981
Score = 2006 bits (5198), Expect = 0.0
Identities = 981/981 (100%), Positives = 981/981 (100%)
Query: 1 MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLI 60
MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLI
Sbjct: 1 MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLI 60
Query: 61 ALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCEL 120
ALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCEL
Sbjct: 61 ALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCEL 120
Query: 121 QKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYD 180
QKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYD
Sbjct: 121 QKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYD 180
Query: 181 SILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAY 240
SILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAY
Sbjct: 181 SILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAY 240
Query: 241 DCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQ 300
DCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQ
Sbjct: 241 DCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQ 300
Query: 301 ATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSD 360
ATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSD
Sbjct: 301 ATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSD 360
Query: 361 QVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSL 420
QVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSL
Sbjct: 361 QVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSL 420
Query: 421 YVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHE 480
YVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHE
Sbjct: 421 YVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHE 480
Query: 481 PFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLA 540
PFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLA
Sbjct: 481 PFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLA 540
Query: 541 GLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDK 600
GLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDK
Sbjct: 541 GLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDK 600
Query: 601 AMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGV 660
AMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGV
Sbjct: 601 AMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGV 660
Query: 661 HHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTC 720
HHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTC
Sbjct: 661 HHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTC 720
Query: 721 EVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNW 780
EVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNW
Sbjct: 721 EVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNW 780
Query: 781 HARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFV 840
HARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFV
Sbjct: 781 HARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFV 840
Query: 841 DLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENE 900
DLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENE
Sbjct: 841 DLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENE 900
Query: 901 MDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQ 960
MDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQ
Sbjct: 901 MDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQ 960
Query: 961 GDPQNATRQQQLEWDDSTLSY 981
GDPQNATRQQQLEWDDSTLSY
Sbjct: 961 GDPQNATRQQQLEWDDSTLSY 981
>gi|57242755 calsyntenin 1 isoform 2 [Homo sapiens]
Length = 971
Score = 1980 bits (5129), Expect = 0.0
Identities = 971/981 (98%), Positives = 971/981 (98%), Gaps = 10/981 (1%)
Query: 1 MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLI 60
MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLI
Sbjct: 1 MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLI 60
Query: 61 ALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCEL 120
ALDKDAPLRFA GEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCEL
Sbjct: 61 ALDKDAPLRFA----------GEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCEL 110
Query: 121 QKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYD 180
QKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYD
Sbjct: 111 QKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYD 170
Query: 181 SILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAY 240
SILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAY
Sbjct: 171 SILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAY 230
Query: 241 DCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQ 300
DCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQ
Sbjct: 231 DCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQ 290
Query: 301 ATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSD 360
ATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSD
Sbjct: 291 ATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSD 350
Query: 361 QVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSL 420
QVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSL
Sbjct: 351 QVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSL 410
Query: 421 YVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHE 480
YVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHE
Sbjct: 411 YVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHE 470
Query: 481 PFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLA 540
PFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLA
Sbjct: 471 PFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLA 530
Query: 541 GLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDK 600
GLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDK
Sbjct: 531 GLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDK 590
Query: 601 AMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGV 660
AMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGV
Sbjct: 591 AMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGV 650
Query: 661 HHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTC 720
HHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTC
Sbjct: 651 HHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTC 710
Query: 721 EVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNW 780
EVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNW
Sbjct: 711 EVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNW 770
Query: 781 HARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFV 840
HARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFV
Sbjct: 771 HARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFV 830
Query: 841 DLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENE 900
DLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENE
Sbjct: 831 DLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENE 890
Query: 901 MDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQ 960
MDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQ
Sbjct: 891 MDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQ 950
Query: 961 GDPQNATRQQQLEWDDSTLSY 981
GDPQNATRQQQLEWDDSTLSY
Sbjct: 951 GDPQNATRQQQLEWDDSTLSY 971
>gi|209364544 calsyntenin 2 [Homo sapiens]
Length = 955
Score = 1099 bits (2843), Expect = 0.0
Identities = 527/968 (54%), Positives = 707/968 (73%), Gaps = 60/968 (6%)
Query: 28 AARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGF 87
AA+VNKHKPW+E +YHG++TEN++TV+LDPPL+ALDKDAP+ FA GEIC F
Sbjct: 34 AAKVNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFA----------GEICAF 83
Query: 88 KIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHK 147
KIHGQ +PF+AVV++K++GEG +R+K +DCELQK+Y+F IQAYDCG GP T KKSHK
Sbjct: 84 KIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPHETAWKKSHK 143
Query: 148 ATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITP 207
A VHIQV DVNE+AP FKE +YKA V EGK YDSIL+VEA+D DCSPQ+SQIC+YEI+T
Sbjct: 144 AVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTT 203
Query: 208 DVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQG 267
DVPF +D++G I+NTEKL+Y K+HQY++ VTAYDCG+K A +D LV++ +KP C PGWQ
Sbjct: 204 DVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQD 263
Query: 268 WNNRIEYEPGTGALAVFPNIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRL 327
W RIEY+PG+G++ +FP+IHLETCD V+S+Q EL+T++IGKGCDR+TYSEKSL +L
Sbjct: 264 WTKRIEYQPGSGSMPLFPSIHLETCDGAVSSLQIVTELQTNYIGKGCDRETYSEKSLQKL 323
Query: 328 CGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSDQVFEFNGTQAVRIPDGVVSVSPKEPFT 387
CGA++G +LLPSPS + NWT GL D+ S+ +F+F+G Q ++PDG+V + + FT
Sbjct: 324 CGASSGIIDLLPSPSAATNWTAGLLVDS---SEMIFKFDGRQGAKVPDGIVPKNLTDQFT 380
Query: 388 ISVWMRHGP---FGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLFRQDPSEEKKYRPA 444
I++WM+HGP +KETILC+SDKT+MNRHHY+LYVH CRL+FL R+D + +RPA
Sbjct: 381 ITMWMKHGPSPGVRAEKETILCNSDKTEMNRHHYALYVHNCRLVFLLRKDFDQADTFRPA 440
Query: 445 EFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHEPFSVTEDYPLHPSKIETQLVVGAC 504
EFHWKL+Q+CD+EWH+YV+NVEFP VTLY+DG ++EP+ VT D+P+HPS I QL VGAC
Sbjct: 441 EFHWKLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLVTNDWPIHPSHIAMQLTVGAC 500
Query: 505 WQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLAGLTLRSGKLADKKVIDCLYTCKEG 564
WQ T+P QFF G+LA LT+R GK+ +KVI CL CKEG
Sbjct: 501 WQ------GGEVTKP----------QFAQFFHGSLASLTIRPGKMESQKVISCLQACKEG 544
Query: 565 LDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDKAMQHISYLNSRQFPTPGIRRLKIT 624
LD+ LE G+G++ +PSQ +L +EG+D+G +++A+Q +SY+NSRQFPT G+RRLK++
Sbjct: 545 LDINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRRLKVS 604
Query: 625 STIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGVHHFARAASEFESSEGVFLFPELRI 684
S ++CF E CIS+P VD YVMVLQ EP+I+L G HF R A++FES+ GV LFP+++I
Sbjct: 605 SKVQCFGEDVCISIPEVDAYVMVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFPDIKI 664
Query: 685 ISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMARLQ 744
+ST + P DP +S V EE++H+LD C++ V G +L+ QE LE++ + L
Sbjct: 665 VSTFAKTEAPGDVKTTDP---KSEVLEEMLHNLDFCDILVIGGDLDPRQECLELNHSELH 721
Query: 745 QKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKLICSELNGRYISN 804
Q+ ++ ++S G + GV +M+ YE+VLH +RYRNW SL R+F++ CSELNGRY SN
Sbjct: 722 QRHLDATNSTAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTSN 781
Query: 805 EFKVEVNVIH--TANPMEHANHMAAQPQFV----HPEHRSFVDLSGHNLANPHPFAVVPS 858
EF +EV+++H + EH NH+ QP F+ HPE RS + S +VVPS
Sbjct: 782 EFNLEVSILHEDQVSDKEHVNHLIVQPPFLQSVHHPESRSSIQHS----------SVVPS 831
Query: 859 TATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENEMDWDDSALTITVNPMETY 918
ATVVI++ V LVF++ +GV+R+R AH+ +++ + KE+EMDWDDSALTITVNPME +
Sbjct: 832 IATVVIIISVCMLVFVVAMGVYRVRIAHQHFIQETEAAKESEMDWDDSALTITVNPMEKH 891
Query: 919 EDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQG-----DPQNATRQQQLE 973
E E+E E EEEEE+ EE+ +S+ S+ SEEEE E+G QN RQ QLE
Sbjct: 892 EGPGHGEDETEGEEEEEA----EEEMSSSSGSDDSEEEEEEEGMGRGRHGQNGARQAQLE 947
Query: 974 WDDSTLSY 981
WDDSTL Y
Sbjct: 948 WDDSTLPY 955
>gi|42475534 calsyntenin 3 [Homo sapiens]
Length = 956
Score = 1016 bits (2626), Expect = 0.0
Identities = 495/957 (51%), Positives = 677/957 (70%), Gaps = 41/957 (4%)
Query: 15 LLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESF 74
LLLA LL + NKHKPW+E Y GIV ENDNTVLL+PPL ALDKDAPLR+A
Sbjct: 8 LLLASLLASCS--CNKANKHKPWIEAEYQGIVMENDNTVLLNPPLFALDKDAPLRYA--- 62
Query: 75 EVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCG 134
GEICGF++HG VPF+AV++DK+TGEG+IR+KE +DCE QK+++FTIQAYDCG
Sbjct: 63 -------GEICGFRLHGSGVPFEAVILDKATGEGLIRAKEPVDCEAQKEHTFTIQAYDCG 115
Query: 135 KGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSP 194
+GPDG N KKSHKATVH++VNDVNE+APVF E+ Y+A V EGK YD ILRVEA+D DCSP
Sbjct: 116 EGPDGANTKKSHKATVHVRVNDVNEFAPVFVERLYRAAVTEGKLYDRILRVEAIDGDCSP 175
Query: 195 QFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVK 254
Q+SQIC YEI+TP+ PF +D DG I+NTEKL Y E YK TVTAYDCGKKRA +D V+
Sbjct: 176 QYSQICYYEILTPNTPFLIDNDGNIENTEKLQYSGERLYKFTVTAYDCGKKRAADDAEVE 235
Query: 255 ISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQATVELETSHIGKGC 314
I +KPTC P WQGWN RIEY PG G+LA+FP I LETCDEP+ ++QAT+EL+TSH+ KGC
Sbjct: 236 IQVKPTCKPSWQGWNKRIEYAPGAGSLALFPGIRLETCDEPLWNIQATIELQTSHVAKGC 295
Query: 315 DRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSDQVFEFNGTQAVRIP 374
DRD YSE++L +LCGAA G +LLP P + NWT GL DS ++ FNGTQAV++P
Sbjct: 296 DRDNYSERALRKLCGAATGEVDLLPMPGPNANWTAGLSVHYSQDSSLIYWFNGTQAVQVP 355
Query: 375 DGVVS-------VSPKEPFTISVWMRHGPFGRK----KETILCSSDKTDMNRHHYSLYVH 423
G S S + FT+S WM+HG K +ETI+C++ + + HYSL VH
Sbjct: 356 LGGPSGLGSGPQDSLSDHFTLSFWMKHGVTPNKGKKEEETIVCNTVQNEDGFSHYSLTVH 415
Query: 424 GCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHEPFS 483
GCR+ FL+ P E RP +F WKL QVCD+EWHHY LN+EFP+VTLY DG S +P
Sbjct: 416 GCRIAFLYW--PLLESA-RPVKFLWKLEQVCDDEWHHYALNLEFPTVTLYTDGISFDPAL 472
Query: 484 VTEDYPLHPSKIETQLVVGACWQEFSGVE---NDNETEPVTVASAGGDLHMTQFFRGNLA 540
+ ++ +HP + E L++GACW E E DN T+ + G L + +F G LA
Sbjct: 473 IHDNGLIHPPRREPALMIGACWTEEKNKEKEKGDNSTD----TTQGDPLSIHHYFHGYLA 528
Query: 541 GLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDK 600
G ++RSG+L ++VI+CLY C+EGLD + E G+G+++ +PSQ +LTLEG+D+ +
Sbjct: 529 GFSVRSGRLESREVIECLYACREGLDYRDFESLGKGMKVHVNPSQSLLTLEGDDVETFNH 588
Query: 601 AMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGV 660
A+QH++Y+N+ +F TPG+R L++T+ +KCF+E +C+S+P V+GYV+VLQP+ P+I LSG
Sbjct: 589 ALQHVAYMNTLRFATPGVRPLRLTTAVKCFSEESCVSIPEVEGYVVVLQPDAPQILLSGT 648
Query: 661 HHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTC 720
HFAR A +FE + GV LFP+L+I +I+ +VE + D + TV ++ +S+EIVH+LD C
Sbjct: 649 AHFARPAVDFEGTNGVPLFPDLQITCSISHQVEAKKDESWQGTVTDTRMSDEIVHNLDGC 708
Query: 721 EVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNW 780
E+++ G++L+ E+ESL +D LQQ+G+E++++ +T GV+++ YEE+L RYR
Sbjct: 709 EISLVGDDLDPERESLLLDTTSLQQRGLELTNTSAYLTIAGVESITVYEEILRQARYRLR 768
Query: 781 HARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFV 840
H +L RKF+L CSE+NGRY SNEF VEVNV+H+ N + H +H+ + QF+H H+
Sbjct: 769 HGAALYTRKFRLSCSEMNGRYSSNEFIVEVNVLHSMNRVAHPSHVLSSQQFLHRGHQPPP 828
Query: 841 DLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTM------RDQD 894
+++GH+LA+ H +++PS AT++IVVCV FLV M++LG+ RI + HRR
Sbjct: 829 EMAGHSLASSHRNSMIPSAATLIIVVCVGFLVLMVVLGLVRIHSLHRRVSGAGGPPGASS 888
Query: 895 TGKENEMDWDDSALTITVNPMETYEDQHS--SEEEEEEEEEEESEDGEEEDDITSAE 949
K+ ++ WDDSALTI VNPME+Y+++ S + ++E+E+S D E D +S E
Sbjct: 889 DPKDPDLFWDDSALTIIVNPMESYQNRQSCVTGAVGGQQEDEDSSDSEVADSPSSDE 945
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 66.2 bits (160), Expect = 1e-10
Identities = 50/168 (29%), Positives = 80/168 (47%), Gaps = 22/168 (13%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G+++ K+KLD E YS +QA D G S ATV+I ++DVN+ +PVF
Sbjct: 3396 GLVKVKKKLDRERVSGYSLLVQAVDSGIPA------MSSTATVNIDISDVNDNSPVFTPA 3449
Query: 168 SYKATVIEGKQY-DSILRVEAVDADC---SPQFSQICSYEIIT--PDVPFTVDKDGYIKN 221
+Y A + E K SIL++ D D P F S+ I++ + F +D G +++
Sbjct: 3450 NYTAVIQENKPVGTSILQLVVTDRDSFHNGPPF----SFSILSGNEEEEFVLDPHGILRS 3505
Query: 222 TEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI------KPTCTP 263
+ + +Y L V A D GK + +++ + KPT P
Sbjct: 3506 AVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIP 3553
Score = 57.4 bits (137), Expect = 6e-08
Identities = 76/299 (25%), Positives = 126/299 (42%), Gaps = 45/299 (15%)
Query: 31 VNKHKPWLE-PTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGE-ICGFK 88
VNK P + P Y V E+ + ++ P+++++ +P EG+ I
Sbjct: 2179 VNKAMPVFDKPFYTASVNED---IRMNTPILSINATSP-------------EGQGIIYII 2222
Query: 89 IHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKA 148
I G PF +D TG V++ LD E+ Y TI+A D G +
Sbjct: 2223 IDGD--PFKQFNIDFDTG--VLKVVSPLDYEVTSAYKLTIRASDALTGARA-------EV 2271
Query: 149 TVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEII-- 205
TV + VNDVN+ P+F + +Y T+ E + +L+V ++DAD + +++ Y+I+
Sbjct: 2272 TVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDAD--SENNKMVHYQIVQD 2329
Query: 206 ---TPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPT-- 260
+ D G I L++ L V + D G + +VLV I I
Sbjct: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389
Query: 261 CTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQATVELETSHIGKGCDRDTY 319
P + N++ YE LA P H TC + + + + I G DR ++
Sbjct: 2390 NPPVF----NQLIYESYVSELA--PRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSF 2442
Score = 53.9 bits (128), Expect = 7e-07
Identities = 65/242 (26%), Positives = 105/242 (43%), Gaps = 46/242 (19%)
Query: 32 NKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICG-FKIH 90
N H ++ Y V EN V + +I + ++S + K+G+I G F I+
Sbjct: 1666 NSHPKFIHKDYQAEVNEN---VDIGTSVILISA-----ISQSTLIYEVKDGDINGIFTIN 1717
Query: 91 GQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVK-KSHKAT 149
P+ GVI +++ LD E Y IQA TN+ + AT
Sbjct: 1718 ----PYS----------GVITTQKALDYERTSSYQLIIQA---------TNMAGMASNAT 1754
Query: 150 VHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILR--------VEAVDADCSPQFSQICS 201
V+IQ+ D N+ APVF Y ++ E +SI+R + A DAD + + +
Sbjct: 1755 VNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNR--NALLV 1812
Query: 202 YEII--TPDVPFTVDKD-GYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIK 258
Y+I+ T FTVD G I+ L++ + V D G + T + V+++I+
Sbjct: 1813 YQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIE 1872
Query: 259 PT 260
T
Sbjct: 1873 VT 1874
Score = 53.9 bits (128), Expect = 7e-07
Identities = 49/152 (32%), Positives = 65/152 (42%), Gaps = 8/152 (5%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G I E LD EL K + ++A DG S ATV+I + DVN+ P F +
Sbjct: 3291 GGISVSEVLDYELCKRFYLVVEA------KDGGTPALSAVATVNINLTDVNDNPPKFSQD 3344
Query: 168 SYKATVIEGKQY-DSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKD-GYIKNTEKL 225
Y A + E DS++ + A D D P S D FTVD G +K +KL
Sbjct: 3345 VYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKL 3404
Query: 226 NYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
+ + Y L V A D G + V I I
Sbjct: 3405 DRERVSGYSLLVQAVDSGIPAMSSTATVNIDI 3436
Score = 52.4 bits (124), Expect = 2e-06
Identities = 49/155 (31%), Positives = 81/155 (52%), Gaps = 15/155 (9%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
GVI + + LD E Y T+ A D G P + ++ V+I+V DVN+ AP+ E
Sbjct: 1098 GVITAADILDRETMGSYWLTVYATDRGVVPLYSTIE------VYIEVEDVNDNAPLTSEP 1151
Query: 168 SYKATVIEGKQYD-SILRVEAVDADCSPQFSQICSYEIIT--PDVPFTVD-KDGYIKNT- 222
Y V+E D S+++++A D D S ++ +Y I + P F ++ K G I T
Sbjct: 1152 IYYPVVMENSPKDVSVIQIQAEDPDSSS--NEKLTYRITSGNPQNFFAINIKTGLITTTS 1209
Query: 223 EKLNYGKEHQYKLTVTAYDCG--KKRATEDVLVKI 255
KL+ ++ ++ L VT D G K++T V+V++
Sbjct: 1210 RKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQV 1244
Score = 50.1 bits (118), Expect = 1e-05
Identities = 41/147 (27%), Positives = 74/147 (50%), Gaps = 15/147 (10%)
Query: 104 STGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPV 163
++ G++ ++LD E + +YS I+A D K G + T+ + ++DVN+ +P
Sbjct: 880 NSSTGIVYVADQLDRESKANYSLKIEARD--KAESGQQLFSV--VTLKVFLDDVNDCSPA 935
Query: 164 FKEKSYKATVIEGKQYDSILR-VEAVDADCS----PQFSQICSYEIITPDVPFTVDK-DG 217
F SY V+E +++ +E D D ++S + Y + F +DK G
Sbjct: 936 FIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDY-----NGRFEIDKASG 990
Query: 218 YIKNTEKLNYGKEHQYKLTVTAYDCGK 244
I+ +++L+Y K+ Y LTV A D G+
Sbjct: 991 AIRLSKELDYEKQQFYNLTVRAKDKGR 1017
Score = 46.6 bits (109), Expect = 1e-04
Identities = 38/143 (26%), Positives = 64/143 (44%), Gaps = 12/143 (8%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
+D TG+ ++ +D E Y I YD G N +KS + I V D N+
Sbjct: 776 IDMETGQ--LKVLMPMDREHTDLYLLNITIYDLG------NPQKSSWRLLTINVEDANDN 827
Query: 161 APVFKEKSYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKD-GY 218
+PVF + SY ++E + I++VEA D D +Y ++T F ++ G
Sbjct: 828 SPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGE--VTYSVLTDTQQFAINSSTGI 885
Query: 219 IKNTEKLNYGKEHQYKLTVTAYD 241
+ ++L+ + Y L + A D
Sbjct: 886 VYVADQLDRESKANYSLKIEARD 908
Score = 44.3 bits (103), Expect = 6e-04
Identities = 30/97 (30%), Positives = 47/97 (48%), Gaps = 2/97 (2%)
Query: 150 VHIQVNDVNEYAPVFKEKSYKATVIEGKQY-DSILRVEAVDADCSPQFSQICSYEIITPD 208
V+IQV D+N+ P+F +Y T+ E S+ +V A DAD + Y D
Sbjct: 144 VNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSN-GEFYYYFKNKVD 202
Query: 209 VPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKK 245
+ G I + +LNY ++++Y L + A D G K
Sbjct: 203 LFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMK 239
Score = 44.3 bits (103), Expect = 6e-04
Identities = 64/242 (26%), Positives = 100/242 (41%), Gaps = 34/242 (14%)
Query: 31 VNKHKPWL-EPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKI 89
VN + P EP Y+ +V EN D +I + + P + E ++I
Sbjct: 1141 VNDNAPLTSEPIYYPVVMENSPK---DVSVIQIQAEDP----------DSSSNEKLTYRI 1187
Query: 90 HGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKAT 149
N P + ++ TG + + KLD E Q ++ + D G P K
Sbjct: 1188 TSGN-PQNFFAINIKTGL-ITTTSRKLDREQQAEHFLEVTVTDGGPSP------KQSTIW 1239
Query: 150 VHIQVNDVNEYAPVFKEKSYKATVIE---GKQYDSILRVEAVDADCSPQFSQICSYEII- 205
V +QV D N+ P F EK Y+ + E K+ + I R A D D P SY I+
Sbjct: 1240 VVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAE--ISYSIVD 1297
Query: 206 -TPDVPFTVD-KDGYIKNTEKLNYGKEHQYKLTVTAYDCGK--KRATEDVLVKISIKPTC 261
D F +D K G + + ++ G LT+ A D G+ K +T + ++ KP
Sbjct: 1298 GNDDGKFFIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPP 1355
Query: 262 TP 263
+P
Sbjct: 1356 SP 1357
Score = 44.3 bits (103), Expect = 6e-04
Identities = 43/159 (27%), Positives = 72/159 (45%), Gaps = 10/159 (6%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
+D STG V+ + E+LD E Q + I D + P N+ A V + V D N++
Sbjct: 1511 IDPSTG--VLYTAERLDHEAQDKHILNIMVRD-QEFPYRRNL-----ARVIVNVEDANDH 1562
Query: 161 APVFKEKSYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKD-GY 218
+P F Y+A+V E S +L+V A+D D I + E F ++ G
Sbjct: 1563 SPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGI 1622
Query: 219 IKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
I ++ + Q+ L++ D G + +V+IS+
Sbjct: 1623 ITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISV 1661
Score = 43.9 bits (102), Expect = 7e-04
Identities = 35/122 (28%), Positives = 59/122 (48%), Gaps = 12/122 (9%)
Query: 87 FKIHGQNVP---FDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVK 143
+ +H + P +A +D +TG I + + LD E ++F++ A D G+
Sbjct: 2851 YSLHSDSQPEKVMEAFNIDSNTGW--ISTLKDLDHETDPTFTFSVVASDLGEA-----FS 2903
Query: 144 KSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAV-DADCSPQFSQICSY 202
S A V ++V D+N+ APVF ++ Y+ V E ++ V + D D S Q+ SY
Sbjct: 2904 LSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQV-SY 2962
Query: 203 EI 204
I
Sbjct: 2963 HI 2964
Score = 43.9 bits (102), Expect = 7e-04
Identities = 41/155 (26%), Positives = 67/155 (43%), Gaps = 7/155 (4%)
Query: 105 TGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVF 164
+ G+I ++ LD E Q Y+ +++A D G +++ TV I V D+N+ PVF
Sbjct: 3182 SSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSL-----TTVTITVLDINDNPPVF 3236
Query: 165 KEKSYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEIITPDVPFTVD-KDGYIKNT 222
+ + Y TV E + +L V A D F ++ K G I +
Sbjct: 3237 ERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVS 3296
Query: 223 EKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
E L+Y ++ L V A D G + V I++
Sbjct: 3297 EVLDYELCKRFYLVVEAKDGGTPALSAVATVNINL 3331
Score = 42.7 bits (99), Expect = 0.002
Identities = 49/154 (31%), Positives = 70/154 (45%), Gaps = 21/154 (13%)
Query: 108 GVIRSKEKLDCELQK-DYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKE 166
G + KE + +L +Y TI A D GK S +V + + VN+ PVF +
Sbjct: 2137 GNVILKEAFNSDLSNIEYGVTILAKDGGK--------PSLSTSVELPITIVNKAMPVFDK 2188
Query: 167 KSYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEII--TPDVPFTVDKD-GYIKNT 222
Y A+V E + ++ IL + A SP+ Q Y II P F +D D G +K
Sbjct: 2189 PFYTASVNEDIRMNTPILSINAT----SPE-GQGIIYIIIDGDPFKQFNIDFDTGVLKVV 2243
Query: 223 EKLNYGKEHQYKLTVTAYDC---GKKRATEDVLV 253
L+Y YKLT+ A D + T D+LV
Sbjct: 2244 SPLDYEVTSAYKLTIRASDALTGARAEVTVDLLV 2277
Score = 41.6 bits (96), Expect = 0.004
Identities = 39/123 (31%), Positives = 60/123 (48%), Gaps = 7/123 (5%)
Query: 140 TNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQY-DSILRVEAVDADCSPQFSQ 198
TN + KA V I + D N++ P F++ Y A V E S+L V A D D +
Sbjct: 448 TNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGE--NG 505
Query: 199 ICSYEIITPD-VPFTVDK-DGYIKNTEKLNYGKEHQ-YKLTVTAYDCGKK-RATEDVLVK 254
+Y I + + +PF +++ G I TE+L++ + Y+ V A D G R +V V
Sbjct: 506 YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
Query: 255 ISI 257
I I
Sbjct: 566 IRI 568
Score = 41.6 bits (96), Expect = 0.004
Identities = 41/157 (26%), Positives = 68/157 (43%), Gaps = 12/157 (7%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
VD STG IR+ LD E + F + D G + V+I+V DVN+
Sbjct: 1826 VDSSTG--AIRTIANLDHETIAHFHFHVHVRDSGS----PQLTAESPVEVNIEVTDVNDN 1879
Query: 161 APVFKEKSYKATVIEGKQYD-SILRVEAVDADCSPQFSQICSYEIITPDVP-FTVDKDGY 218
PVF + ++ ++ +L+V A D D + +Y ++ + F +D +
Sbjct: 1880 PPVFTQAVFETILLLPTYVGVEVLKVSATDPD--SEVPPELTYSLMEGSLDHFLIDSNSG 1937
Query: 219 IKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKI 255
+ + N K+H Y L V D GK +T V + +
Sbjct: 1938 VLTIKNNNLSKDH-YMLIVKVSD-GKFYSTSMVTIMV 1972
Score = 39.7 bits (91), Expect = 0.014
Identities = 39/143 (27%), Positives = 64/143 (44%), Gaps = 13/143 (9%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
+D +GE +++ LD E YS +A D G + ++ +H+ + DVN+
Sbjct: 3078 LDPESGE--LKTLALLDRERIPVYSLMAKATDGGG--------RFCQSNIHLILEDVNDN 3127
Query: 161 APVFKEKSYKATVIEGKQYDSIL-RVEAVDADCSPQFSQICSYEIITPDVPFTVD-KDGY 218
PVF Y V E ++L RV+AVD D + S V F++D G
Sbjct: 3128 PPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGV-FSIDSSSGI 3186
Query: 219 IKNTEKLNYGKEHQYKLTVTAYD 241
I + L+ ++ Y ++V A D
Sbjct: 3187 IILEQPLDREQQSSYNISVRATD 3209
Score = 39.3 bits (90), Expect = 0.018
Identities = 29/82 (35%), Positives = 42/82 (51%), Gaps = 5/82 (6%)
Query: 148 ATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEIIT 206
A VHI+V N Y+P F + +Y A V E + ++ V A D D + QI SY II
Sbjct: 2480 AQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGD-PGTYGQI-SYAIIN 2537
Query: 207 PDVP--FTVDKDGYIKNTEKLN 226
F +D +G + TE+L+
Sbjct: 2538 DFAKDRFLIDSNGQVITTERLD 2559
Score = 38.9 bits (89), Expect = 0.024
Identities = 38/153 (24%), Positives = 70/153 (45%), Gaps = 17/153 (11%)
Query: 100 VVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNE 159
V+++ TG I+ ++LD E + F + A V V I+V D+N+
Sbjct: 2757 VIEQETG--TIKLDKRLDRETSPAFHFKVAATI-----PLDKVDIVFTVDVDIKVLDLND 2809
Query: 160 YAPVFKEKSYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEIITPDVP------FT 212
PVF+ SY ++EG + + +V A+D D Q+ +Y + + P F
Sbjct: 2810 NKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGAN-GQV-TYSLHSDSQPEKVMEAFN 2867
Query: 213 VDKD-GYIKNTEKLNYGKEHQYKLTVTAYDCGK 244
+D + G+I + L++ + + +V A D G+
Sbjct: 2868 IDSNTGWISTLKDLDHETDPTFTFSVVASDLGE 2900
Score = 37.0 bits (84), Expect = 0.091
Identities = 39/168 (23%), Positives = 68/168 (40%), Gaps = 19/168 (11%)
Query: 103 KSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAP 162
KST + + D E Q+ Y ++A + D V + V + + D+N+ +P
Sbjct: 2029 KSTSGVIQTTGVPFDREEQELYELVVEA---SRELDHLRVAR---VVVRVNIEDINDNSP 2082
Query: 163 VFKEKSYKATV-IEGKQYDSILRVEAVDADCSPQ------FSQICSYEIITPDVPFTVDK 215
VF Y A V ++ + I +V A+D D P + I P+ + K
Sbjct: 2083 VFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVILK 2142
Query: 216 DGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTP 263
+ + + + YG +T+ A D GK + V + I+I P
Sbjct: 2143 EAFNSDLSNIEYG------VTILAKDGGKPSLSTSVELPITIVNKAMP 2184
Score = 35.0 bits (79), Expect = 0.34
Identities = 36/145 (24%), Positives = 64/145 (44%), Gaps = 13/145 (8%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
GVI +L+ + + Y I A D G G N S A +++ + +NE+AP
Sbjct: 211 GVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSS-TAKLYVHIERINEHAPTIHVV 269
Query: 168 SYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDV--PFTVDKDGYIKNTEKL 225
++ +E + +++ V+ +D + +I S I+ D F + K+G N K+
Sbjct: 270 THVPFSLEKEPTYAVVTVDDLDDGAN---GEIESVSIVAGDPLDQFFLAKEGKWLNEYKI 326
Query: 226 NYGKE-------HQYKLTVTAYDCG 243
K+ + Y LT+ A D G
Sbjct: 327 KERKQIDWESFPYGYNLTLQAKDKG 351
Score = 33.9 bits (76), Expect = 0.77
Identities = 38/145 (26%), Positives = 69/145 (47%), Gaps = 24/145 (16%)
Query: 108 GVIRSKEKLDCELQKD-YSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKE 166
GVI + E+LD E + Y F ++A D G + + + V I++ +VN+ +P+F++
Sbjct: 526 GVISTTEELDFESSPEIYRFIVRASDWG-----SPYRHESEVNVTIRIGNVNDNSPLFEK 580
Query: 167 KSYKATVIEGKQYD-----SILRVEAVDADCSPQFSQICSYEIITPDVP--FTVDKDGYI 219
+ + + YD I V A+D D ++ Y+II+ + F ++ D +
Sbjct: 581 VACQGVI----SYDFPVGGHITAVSAIDID----ELELVKYKIISGNELGFFYLNPDSGV 632
Query: 220 KNTEK--LNYG-KEHQYKLTVTAYD 241
+K N G K + L +TA D
Sbjct: 633 LQLKKSLTNSGIKNGNFALRITATD 657
Score = 32.7 bits (73), Expect = 1.7
Identities = 29/80 (36%), Positives = 39/80 (48%), Gaps = 10/80 (12%)
Query: 113 KEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKAT 172
K LD E Q Y I A DG V + A V + V+DVN+ +PV + +Y A
Sbjct: 2987 KRPLDREEQDIYFLNITA------TDGLFVTQ---AMVEVSVSDVNDNSPVCDQVAYTAL 3037
Query: 173 VIEGKQYDS-ILRVEAVDAD 191
+ E + IL+V A DAD
Sbjct: 3038 LPEDIPSNKIILKVSAKDAD 3057
Score = 31.6 bits (70), Expect = 3.8
Identities = 28/98 (28%), Positives = 49/98 (50%), Gaps = 14/98 (14%)
Query: 97 DAVVVDKSTGEGVIRSKEKLDCE--LQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQV 154
D ++D + G + + E+LD E L+ D S ++A D G ++ TV + V
Sbjct: 2542 DRFLIDSN---GQVITTERLDRENPLEGDVSIFVRALDGGG--------RTTFCTVRVIV 2590
Query: 155 NDVNEYAPVFKEKSYKATV-IEGKQYDSILRVEAVDAD 191
D N+ AP F Y+A+V + + + +V+A+D D
Sbjct: 2591 VDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPD 2628
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 63.2 bits (152), Expect = 1e-09
Identities = 43/159 (27%), Positives = 74/159 (46%), Gaps = 9/159 (5%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
+D TGE I+ LD E +++Y+ I+A D G+ P N IQV D+N++
Sbjct: 595 IDSLTGE--IQVVAPLDFEAEREYALRIRAQDAGRPPLSNNT-----GLASIQVVDINDH 647
Query: 161 APVFKEKSYKATVIEGKQY-DSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDK-DGY 218
P+F ++ +V+E S++ ++AVDAD S + PD PF ++ G+
Sbjct: 648 IPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGW 707
Query: 219 IKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
+ + L+ Y V A D G + V +++
Sbjct: 708 VSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTV 746
Score = 58.5 bits (140), Expect = 3e-08
Identities = 45/141 (31%), Positives = 69/141 (48%), Gaps = 10/141 (7%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G+I + ++D E + Y ++A D G+ P +S VHI V D N+ AP F EK
Sbjct: 493 GLISTSGRVDREHMESYELVVEASDQGQEPG----PRSATVRVHITVLDENDNAPQFSEK 548
Query: 168 SYKATVIEG-KQYDSILRVEAVDADCSPQFSQICSYEIITPDV--PFTVDK-DGYIKNTE 223
Y A V E + + +LRV A D D + + Y II+ + F +D G I+
Sbjct: 549 RYVAQVREDVRPHTVVLRVTATDRD--KDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606
Query: 224 KLNYGKEHQYKLTVTAYDCGK 244
L++ E +Y L + A D G+
Sbjct: 607 PLDFEAEREYALRIRAQDAGR 627
Score = 50.8 bits (120), Expect = 6e-06
Identities = 39/136 (28%), Positives = 63/136 (46%), Gaps = 12/136 (8%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G++R+ +LD E Y T A D G P T V ++ + V DVN+ APVF +
Sbjct: 1017 GIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPV------SIQVMVQDVNDNAPVFPAE 1070
Query: 168 SYKATVIEGKQYDSIL-RVEAVDADCSPQFSQICSYEIITPDVPFTVDKD---GYIKNTE 223
++ V E S++ ++ AVD D P + Y+I+ ++P D G +
Sbjct: 1071 EFEVRVKENSIVGSVVAQITAVDPDEGP--NAHIMYQIVEGNIPELFQMDIFSGELTALI 1128
Query: 224 KLNYGKEHQYKLTVTA 239
L+Y +Y + V A
Sbjct: 1129 DLDYEARQEYVIVVQA 1144
Score = 49.3 bits (116), Expect = 2e-05
Identities = 53/230 (23%), Positives = 88/230 (38%), Gaps = 26/230 (11%)
Query: 32 NKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHG 91
N H+P + ++ + D + +I+ D E+ +T E + F+I
Sbjct: 852 NTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDD---VGENARITYLLEDNLPQFRIDA 908
Query: 92 QNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVH 151
+ G I + LD E Q Y+ I A D G +K+ V
Sbjct: 909 DS--------------GAITLQAPLDYEDQVTYTLAITARDNGIP------QKADTTYVE 948
Query: 152 IQVNDVNEYAPVFKEKSYKATVIE-GKQYDSILRVEAVDADCSPQFS-QICSYEIITPDV 209
+ VNDVN+ AP F Y V E + S+L++ A D D Q D
Sbjct: 949 VMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDG 1008
Query: 210 PFTVD-KDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIK 258
FT++ G ++ +L+ Y+LT A D G V +++ ++
Sbjct: 1009 DFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQ 1058
Score = 47.0 bits (110), Expect = 9e-05
Identities = 55/213 (25%), Positives = 86/213 (40%), Gaps = 28/213 (13%)
Query: 49 NDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFD----------- 97
++NT L ++ ++ P+ + F+V+V + + IH Q V D
Sbjct: 631 SNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSL 690
Query: 98 -------AVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATV 150
V++ +TG + LD E + Y F ++A D G P S A+V
Sbjct: 691 TGVAPDTPFVINSATGW--VSVSGPLDRESVEHYFFGVEARDHGSPP------LSASASV 742
Query: 151 HIQVNDVNEYAPVFKEKSYKATVIEGKQY-DSILRVEAVDADCSPQFS-QICSYEIITPD 208
+ V DVN+ P F K Y + E S++ V AVD D + S QI
Sbjct: 743 TVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRF 802
Query: 209 VPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYD 241
T G + L+Y +E +KL +TA D
Sbjct: 803 AISTQGGVGLVTLALPLDYKQERYFKLVLTASD 835
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/110 (27%), Positives = 53/110 (48%), Gaps = 4/110 (3%)
Query: 150 VHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDV 209
VHI + D N + PVF+ Y +V E + S + V + D + ++I ++ ++
Sbjct: 844 VHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARIT--YLLEDNL 901
Query: 210 P-FTVDKD-GYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
P F +D D G I L+Y + Y L +TA D G + + V++ +
Sbjct: 902 PQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMV 951
Score = 33.1 bits (74), Expect = 1.3
Identities = 39/154 (25%), Positives = 64/154 (41%), Gaps = 32/154 (20%)
Query: 62 LDKDAPLRFAESFEVTVTKEGEICGFKI---------HGQNVPFDAVVVDKSTGE----- 107
++ +AP+ AE FEV V KE I G + G N +V+ + E
Sbjct: 1060 VNDNAPVFPAEEFEVRV-KENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMD 1118
Query: 108 ---GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVF 164
G + + LD E +++Y +QA T+ +ATVH+++ D N+ +PV
Sbjct: 1119 IFSGELTALIDLDYEARQEYVIVVQA---------TSAPLVSRATVHVRLVDQNDNSPVL 1169
Query: 165 KE-----KSYKATVIEGKQYDSILRVEAVDADCS 193
+Y + + I R+ A D D S
Sbjct: 1170 NNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVS 1203
>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
sapiens]
Length = 1021
Score = 62.4 bits (150), Expect = 2e-09
Identities = 72/260 (27%), Positives = 117/260 (45%), Gaps = 33/260 (12%)
Query: 11 PAARLLLAGLLCGGGVWAAR---------VNKHKPWLEPTYHGIVTENDNTVLLDPPLIA 61
P +LL+ L GG+ AR VN + P ++ Y IV ++TV+L +
Sbjct: 321 PNHKLLV--LASDGGLMPARAMVLVNVTDVNDNVPSIDIRY--IVNPVNDTVVLSENIPL 376
Query: 62 LDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQ 121
K A + + G + F H +PF V + + ++ + LD E
Sbjct: 377 NTKIALITVTDK---DADHNGRVTCFTDH--EIPFRLRPV--FSNQFLLETAAYLDYEST 429
Query: 122 KDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYD- 180
K+Y+ + A D GK P + A + I+V D N+ APVF + ++ E
Sbjct: 430 KEYAIKLLAADAGKPP------LNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 483
Query: 181 SILRVEAVDADCSPQFSQICSYEIITPDVP--FTVD-KDGYIKNTEKLNYGKEHQYKLTV 237
+ +V A+DAD P +Y ++ PD P F++D + G + +KL+ KE +Y T+
Sbjct: 484 QLTKVSAMDADSGPNAK--INY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTI 540
Query: 238 TAYDCGKKRATEDVLVKISI 257
A D G T +V V +SI
Sbjct: 541 LAKDNGVPPLTSNVTVFVSI 560
Score = 48.9 bits (115), Expect = 2e-05
Identities = 41/152 (26%), Positives = 68/152 (44%), Gaps = 10/152 (6%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G++ +KLD E + Y FTI A D G P +NV TV + + D N+ +PVF
Sbjct: 520 GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNV------TVFVSIIDQNDNSPVFTHN 573
Query: 168 SYKATVIEG-KQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVD-KDGYIKNTEKL 225
Y V E ++ ++ + D D + + I+ + FT+D + G I+
Sbjct: 574 EYNFYVPENLPRHGTVGLITVTDPDYGD--NSAVTLSILDENDDFTIDSQTGVIRPNISF 631
Query: 226 NYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
+ K+ Y V A D G+ + V I++
Sbjct: 632 DREKQESYTFYVKAEDGGRVSRSSSAKVTINV 663
Score = 46.6 bits (109), Expect = 1e-04
Identities = 49/165 (29%), Positives = 75/165 (45%), Gaps = 19/165 (11%)
Query: 97 DAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVND 156
D +D TG VIR D E Q+ Y+F ++A D G+ V +S A V I V D
Sbjct: 614 DDFTIDSQTG--VIRPNISFDREKQESYTFYVKAEDGGR------VSRSSSAKVTINVVD 665
Query: 157 VNEYAPVF----KEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEII---TPDV 209
VN+ PVF SY+ + + +V AVD D + Y I+ T D+
Sbjct: 666 VNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTG--MNAEVRYSIVGGNTRDL 723
Query: 210 PFTVDKD-GYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLV 253
F +D++ G I EK + +++ V A D G+ + V++
Sbjct: 724 -FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Score = 42.0 bits (97), Expect = 0.003
Identities = 48/203 (23%), Positives = 86/203 (42%), Gaps = 26/203 (12%)
Query: 61 ALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGV--IRSKEKLDC 118
A+D D + +++E+ I QN+ F V++ G+ + + +++LD
Sbjct: 163 AVDPDVGINGVQNYEL------------IKSQNI-FGLDVIETPEGDKMPQLIVQKELDR 209
Query: 119 ELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQ 178
E + Y + K DG ++S A + + V D N+ PVFKE + ++ E
Sbjct: 210 EEKDTYVMKV------KVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAP 263
Query: 179 Y-DSILRVEAVDADCSPQFSQICSYEIITPDVPFTV----DKDGYIKNTEKLNYGKEHQY 233
S+ ++ A DAD S+ + ++ + G I E L+ + +
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 234 KLTVTAYDCGKKRATEDVLVKIS 256
KL V A D G A VLV ++
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVT 346
Score = 32.0 bits (71), Expect = 2.9
Identities = 37/164 (22%), Positives = 65/164 (39%), Gaps = 26/164 (15%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G+I KE LD E ++ + A D G P +A V + V DVN+ P +
Sbjct: 307 GLITIKEPLDREETPNHKLLVLASDGGLMPA--------RAMVLVNVTDVNDNVPSIDIR 358
Query: 168 ----SYKATVIEGKQYD-----SILRVEAVDADCSPQFSQICSYEIITPDVPFTV----D 214
TV+ + +++ V DAD + + + +EI PF +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI-----PFRLRPVFS 413
Query: 215 KDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIK 258
++ L+Y +Y + + A D GK + ++ I +K
Sbjct: 414 NQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 457
>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
Length = 1337
Score = 62.4 bits (150), Expect = 2e-09
Identities = 72/260 (27%), Positives = 117/260 (45%), Gaps = 33/260 (12%)
Query: 11 PAARLLLAGLLCGGGVWAAR---------VNKHKPWLEPTYHGIVTENDNTVLLDPPLIA 61
P +LL+ L GG+ AR VN + P ++ Y IV ++TV+L +
Sbjct: 321 PNHKLLV--LASDGGLMPARAMVLVNVTDVNDNVPSIDIRY--IVNPVNDTVVLSENIPL 376
Query: 62 LDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQ 121
K A + + G + F H +PF V + + ++ + LD E
Sbjct: 377 NTKIALITVTDK---DADHNGRVTCFTDH--EIPFRLRPV--FSNQFLLETAAYLDYEST 429
Query: 122 KDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYD- 180
K+Y+ + A D GK P + A + I+V D N+ APVF + ++ E
Sbjct: 430 KEYAIKLLAADAGKPP------LNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 483
Query: 181 SILRVEAVDADCSPQFSQICSYEIITPDVP--FTVD-KDGYIKNTEKLNYGKEHQYKLTV 237
+ +V A+DAD P +Y ++ PD P F++D + G + +KL+ KE +Y T+
Sbjct: 484 QLTKVSAMDADSGPNAK--INY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTI 540
Query: 238 TAYDCGKKRATEDVLVKISI 257
A D G T +V V +SI
Sbjct: 541 LAKDNGVPPLTSNVTVFVSI 560
Score = 48.9 bits (115), Expect = 2e-05
Identities = 41/152 (26%), Positives = 68/152 (44%), Gaps = 10/152 (6%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G++ +KLD E + Y FTI A D G P +NV TV + + D N+ +PVF
Sbjct: 520 GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNV------TVFVSIIDQNDNSPVFTHN 573
Query: 168 SYKATVIEG-KQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVD-KDGYIKNTEKL 225
Y V E ++ ++ + D D + + I+ + FT+D + G I+
Sbjct: 574 EYNFYVPENLPRHGTVGLITVTDPDYGD--NSAVTLSILDENDDFTIDSQTGVIRPNISF 631
Query: 226 NYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
+ K+ Y V A D G+ + V I++
Sbjct: 632 DREKQESYTFYVKAEDGGRVSRSSSAKVTINV 663
Score = 46.6 bits (109), Expect = 1e-04
Identities = 49/165 (29%), Positives = 75/165 (45%), Gaps = 19/165 (11%)
Query: 97 DAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVND 156
D +D TG VIR D E Q+ Y+F ++A D G+ V +S A V I V D
Sbjct: 614 DDFTIDSQTG--VIRPNISFDREKQESYTFYVKAEDGGR------VSRSSSAKVTINVVD 665
Query: 157 VNEYAPVF----KEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEII---TPDV 209
VN+ PVF SY+ + + +V AVD D + Y I+ T D+
Sbjct: 666 VNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTG--MNAEVRYSIVGGNTRDL 723
Query: 210 PFTVDKD-GYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLV 253
F +D++ G I EK + +++ V A D G+ + V++
Sbjct: 724 -FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Score = 42.0 bits (97), Expect = 0.003
Identities = 48/203 (23%), Positives = 86/203 (42%), Gaps = 26/203 (12%)
Query: 61 ALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGV--IRSKEKLDC 118
A+D D + +++E+ I QN+ F V++ G+ + + +++LD
Sbjct: 163 AVDPDVGINGVQNYEL------------IKSQNI-FGLDVIETPEGDKMPQLIVQKELDR 209
Query: 119 ELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQ 178
E + Y + K DG ++S A + + V D N+ PVFKE + ++ E
Sbjct: 210 EEKDTYVMKV------KVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAP 263
Query: 179 Y-DSILRVEAVDADCSPQFSQICSYEIITPDVPFTV----DKDGYIKNTEKLNYGKEHQY 233
S+ ++ A DAD S+ + ++ + G I E L+ + +
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 234 KLTVTAYDCGKKRATEDVLVKIS 256
KL V A D G A VLV ++
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVT 346
Score = 32.0 bits (71), Expect = 2.9
Identities = 37/164 (22%), Positives = 65/164 (39%), Gaps = 26/164 (15%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G+I KE LD E ++ + A D G P +A V + V DVN+ P +
Sbjct: 307 GLITIKEPLDREETPNHKLLVLASDGGLMPA--------RAMVLVNVTDVNDNVPSIDIR 358
Query: 168 ----SYKATVIEGKQYD-----SILRVEAVDADCSPQFSQICSYEIITPDVPFTV----D 214
TV+ + +++ V DAD + + + +EI PF +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI-----PFRLRPVFS 413
Query: 215 KDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIK 258
++ L+Y +Y + + A D GK + ++ I +K
Sbjct: 414 NQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 457
>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
Length = 1347
Score = 62.4 bits (150), Expect = 2e-09
Identities = 72/260 (27%), Positives = 117/260 (45%), Gaps = 33/260 (12%)
Query: 11 PAARLLLAGLLCGGGVWAAR---------VNKHKPWLEPTYHGIVTENDNTVLLDPPLIA 61
P +LL+ L GG+ AR VN + P ++ Y IV ++TV+L +
Sbjct: 321 PNHKLLV--LASDGGLMPARAMVLVNVTDVNDNVPSIDIRY--IVNPVNDTVVLSENIPL 376
Query: 62 LDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQ 121
K A + + G + F H +PF V + + ++ + LD E
Sbjct: 377 NTKIALITVTDK---DADHNGRVTCFTDH--EIPFRLRPV--FSNQFLLETAAYLDYEST 429
Query: 122 KDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYD- 180
K+Y+ + A D GK P + A + I+V D N+ APVF + ++ E
Sbjct: 430 KEYAIKLLAADAGKPP------LNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 483
Query: 181 SILRVEAVDADCSPQFSQICSYEIITPDVP--FTVD-KDGYIKNTEKLNYGKEHQYKLTV 237
+ +V A+DAD P +Y ++ PD P F++D + G + +KL+ KE +Y T+
Sbjct: 484 QLTKVSAMDADSGPNAK--INY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTI 540
Query: 238 TAYDCGKKRATEDVLVKISI 257
A D G T +V V +SI
Sbjct: 541 LAKDNGVPPLTSNVTVFVSI 560
Score = 48.9 bits (115), Expect = 2e-05
Identities = 41/152 (26%), Positives = 68/152 (44%), Gaps = 10/152 (6%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G++ +KLD E + Y FTI A D G P +NV TV + + D N+ +PVF
Sbjct: 520 GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNV------TVFVSIIDQNDNSPVFTHN 573
Query: 168 SYKATVIEG-KQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVD-KDGYIKNTEKL 225
Y V E ++ ++ + D D + + I+ + FT+D + G I+
Sbjct: 574 EYNFYVPENLPRHGTVGLITVTDPDYGD--NSAVTLSILDENDDFTIDSQTGVIRPNISF 631
Query: 226 NYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
+ K+ Y V A D G+ + V I++
Sbjct: 632 DREKQESYTFYVKAEDGGRVSRSSSAKVTINV 663
Score = 46.6 bits (109), Expect = 1e-04
Identities = 49/165 (29%), Positives = 75/165 (45%), Gaps = 19/165 (11%)
Query: 97 DAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVND 156
D +D TG VIR D E Q+ Y+F ++A D G+ V +S A V I V D
Sbjct: 614 DDFTIDSQTG--VIRPNISFDREKQESYTFYVKAEDGGR------VSRSSSAKVTINVVD 665
Query: 157 VNEYAPVF----KEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEII---TPDV 209
VN+ PVF SY+ + + +V AVD D + Y I+ T D+
Sbjct: 666 VNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTG--MNAEVRYSIVGGNTRDL 723
Query: 210 PFTVDKD-GYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLV 253
F +D++ G I EK + +++ V A D G+ + V++
Sbjct: 724 -FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Score = 42.0 bits (97), Expect = 0.003
Identities = 48/203 (23%), Positives = 86/203 (42%), Gaps = 26/203 (12%)
Query: 61 ALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGV--IRSKEKLDC 118
A+D D + +++E+ I QN+ F V++ G+ + + +++LD
Sbjct: 163 AVDPDVGINGVQNYEL------------IKSQNI-FGLDVIETPEGDKMPQLIVQKELDR 209
Query: 119 ELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQ 178
E + Y + K DG ++S A + + V D N+ PVFKE + ++ E
Sbjct: 210 EEKDTYVMKV------KVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAP 263
Query: 179 Y-DSILRVEAVDADCSPQFSQICSYEIITPDVPFTV----DKDGYIKNTEKLNYGKEHQY 233
S+ ++ A DAD S+ + ++ + G I E L+ + +
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 234 KLTVTAYDCGKKRATEDVLVKIS 256
KL V A D G A VLV ++
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVT 346
Score = 32.0 bits (71), Expect = 2.9
Identities = 37/164 (22%), Positives = 65/164 (39%), Gaps = 26/164 (15%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G+I KE LD E ++ + A D G P +A V + V DVN+ P +
Sbjct: 307 GLITIKEPLDREETPNHKLLVLASDGGLMPA--------RAMVLVNVTDVNDNVPSIDIR 358
Query: 168 ----SYKATVIEGKQYD-----SILRVEAVDADCSPQFSQICSYEIITPDVPFTV----D 214
TV+ + +++ V DAD + + + +EI PF +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI-----PFRLRPVFS 413
Query: 215 KDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIK 258
++ L+Y +Y + + A D GK + ++ I +K
Sbjct: 414 NQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 457
>gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo
sapiens]
Length = 1025
Score = 62.4 bits (150), Expect = 2e-09
Identities = 72/260 (27%), Positives = 117/260 (45%), Gaps = 33/260 (12%)
Query: 11 PAARLLLAGLLCGGGVWAAR---------VNKHKPWLEPTYHGIVTENDNTVLLDPPLIA 61
P +LL+ L GG+ AR VN + P ++ Y IV ++TV+L +
Sbjct: 321 PNHKLLV--LASDGGLMPARAMVLVNVTDVNDNVPSIDIRY--IVNPVNDTVVLSENIPL 376
Query: 62 LDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQ 121
K A + + G + F H +PF V + + ++ + LD E
Sbjct: 377 NTKIALITVTDK---DADHNGRVTCFTDH--EIPFRLRPV--FSNQFLLETAAYLDYEST 429
Query: 122 KDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYD- 180
K+Y+ + A D GK P + A + I+V D N+ APVF + ++ E
Sbjct: 430 KEYAIKLLAADAGKPP------LNQSAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGI 483
Query: 181 SILRVEAVDADCSPQFSQICSYEIITPDVP--FTVD-KDGYIKNTEKLNYGKEHQYKLTV 237
+ +V A+DAD P +Y ++ PD P F++D + G + +KL+ KE +Y T+
Sbjct: 484 QLTKVSAMDADSGPNAK--INY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTI 540
Query: 238 TAYDCGKKRATEDVLVKISI 257
A D G T +V V +SI
Sbjct: 541 LAKDNGVPPLTSNVTVFVSI 560
Score = 48.9 bits (115), Expect = 2e-05
Identities = 41/152 (26%), Positives = 68/152 (44%), Gaps = 10/152 (6%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G++ +KLD E + Y FTI A D G P +NV TV + + D N+ +PVF
Sbjct: 520 GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNV------TVFVSIIDQNDNSPVFTHN 573
Query: 168 SYKATVIEG-KQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVD-KDGYIKNTEKL 225
Y V E ++ ++ + D D + + I+ + FT+D + G I+
Sbjct: 574 EYNFYVPENLPRHGTVGLITVTDPDYGD--NSAVTLSILDENDDFTIDSQTGVIRPNISF 631
Query: 226 NYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
+ K+ Y V A D G+ + V I++
Sbjct: 632 DREKQESYTFYVKAEDGGRVSRSSSAKVTINV 663
Score = 46.6 bits (109), Expect = 1e-04
Identities = 49/165 (29%), Positives = 75/165 (45%), Gaps = 19/165 (11%)
Query: 97 DAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVND 156
D +D TG VIR D E Q+ Y+F ++A D G+ V +S A V I V D
Sbjct: 614 DDFTIDSQTG--VIRPNISFDREKQESYTFYVKAEDGGR------VSRSSSAKVTINVVD 665
Query: 157 VNEYAPVF----KEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEII---TPDV 209
VN+ PVF SY+ + + +V AVD D + Y I+ T D+
Sbjct: 666 VNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTG--MNAEVRYSIVGGNTRDL 723
Query: 210 PFTVDKD-GYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLV 253
F +D++ G I EK + +++ V A D G+ + V++
Sbjct: 724 -FAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQPDSLFSVVI 767
Score = 42.0 bits (97), Expect = 0.003
Identities = 48/203 (23%), Positives = 86/203 (42%), Gaps = 26/203 (12%)
Query: 61 ALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGV--IRSKEKLDC 118
A+D D + +++E+ I QN+ F V++ G+ + + +++LD
Sbjct: 163 AVDPDVGINGVQNYEL------------IKSQNI-FGLDVIETPEGDKMPQLIVQKELDR 209
Query: 119 ELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQ 178
E + Y + K DG ++S A + + V D N+ PVFKE + ++ E
Sbjct: 210 EEKDTYVMKV------KVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAP 263
Query: 179 Y-DSILRVEAVDADCSPQFSQICSYEIITPDVPFTV----DKDGYIKNTEKLNYGKEHQY 233
S+ ++ A DAD S+ + ++ + G I E L+ + +
Sbjct: 264 VGTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNH 323
Query: 234 KLTVTAYDCGKKRATEDVLVKIS 256
KL V A D G A VLV ++
Sbjct: 324 KLLVLASDGGLMPARAMVLVNVT 346
Score = 32.0 bits (71), Expect = 2.9
Identities = 37/164 (22%), Positives = 65/164 (39%), Gaps = 26/164 (15%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G+I KE LD E ++ + A D G P +A V + V DVN+ P +
Sbjct: 307 GLITIKEPLDREETPNHKLLVLASDGGLMPA--------RAMVLVNVTDVNDNVPSIDIR 358
Query: 168 ----SYKATVIEGKQYD-----SILRVEAVDADCSPQFSQICSYEIITPDVPFTV----D 214
TV+ + +++ V DAD + + + +EI PF +
Sbjct: 359 YIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEI-----PFRLRPVFS 413
Query: 215 KDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIK 258
++ L+Y +Y + + A D GK + ++ I +K
Sbjct: 414 NQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVK 457
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 60.8 bits (146), Expect = 6e-09
Identities = 58/215 (26%), Positives = 102/215 (47%), Gaps = 26/215 (12%)
Query: 62 LDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDA--------VVVDKSTGE------ 107
++ +AP A+ + +TV + E Q DA ++D + G+
Sbjct: 3118 VNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINEL 3177
Query: 108 -GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKE 166
G+I+ ++ LD ELQ Y+ +++A D G + + TV + V D+N+ PVF+
Sbjct: 3178 SGIIQLEKPLDRELQAVYTLSLKAVD-----QGLPRRLTATGTVIVSVLDINDNPPVFEY 3232
Query: 167 KSYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEIITPDV--PFTVD-KDGYIKNT 222
+ Y ATV E + +L+V A D + + +Y II+ + F++D K G +
Sbjct: 3233 REYGATVSEDILVGTEVLQVYAASRDI--EANAEITYSIISGNEHGKFSIDSKTGAVFII 3290
Query: 223 EKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
E L+Y H+Y LTV A D G ++ V +++
Sbjct: 3291 ENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNV 3325
Score = 58.5 bits (140), Expect = 3e-08
Identities = 45/163 (27%), Positives = 80/163 (49%), Gaps = 14/163 (8%)
Query: 100 VVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNE 159
++D TG +++ LD E Y+ I YD G +K+ +H+ V D N+
Sbjct: 766 MIDMETG--MLKILSPLDRETTDKYTLNITVYDLGIP------QKAAWRLLHVVVVDAND 817
Query: 160 YAPVFKEKSYKATVIEGKQ-YDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDK-DG 217
P F ++SY V E K+ + I++VEA D D P + +Y I+T F++D G
Sbjct: 818 NPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGP--NGHVTYSIVTDTDTFSIDSVTG 875
Query: 218 YIKNTEKLNYGKEHQYKLTVTAYDCGKK--RATEDVLVKISIK 258
+ L+ +H++ L + A D ++ + V+VK+S++
Sbjct: 876 VVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLE 918
Score = 57.4 bits (137), Expect = 6e-08
Identities = 53/161 (32%), Positives = 72/161 (44%), Gaps = 14/161 (8%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
+D TG I E LD E +Y T++A DG S ATV++ V D+N+
Sbjct: 3280 IDSKTGAVFII--ENLDYESSHEYYLTVEA------TDGGTPSLSDVATVNVNVTDINDN 3331
Query: 161 APVFKEKSYKATVIEGKQYD-SILRVEAVDADCSPQFSQICSYEII--TPDVPFTVDK-D 216
PVF + +Y + E + S++ V A DAD P S I Y II FT+D
Sbjct: 3332 TPVFSQDTYTTVISEDAVLEQSVITVMADDAD-GPSNSHI-HYSIIDGNQGSSFTIDPVR 3389
Query: 217 GYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
G +K T+ L+ Y LTV A D G V I +
Sbjct: 3390 GEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDV 3430
Score = 56.6 bits (135), Expect = 1e-07
Identities = 58/233 (24%), Positives = 101/233 (43%), Gaps = 33/233 (14%)
Query: 31 VNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIH 90
+NK P E ++ E ++ + P++ + ++P + +T +G+
Sbjct: 2175 MNKAMPVFEKPFYS--AEIAESIQVHSPVVHVQANSPEGLKVFYSIT---DGD------- 2222
Query: 91 GQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATV 150
PF ++ +TG VI LD E Y +I+A D G + V
Sbjct: 2223 ----PFSQFTINFNTG--VINVIAPLDFEAHPAYKLSIRATDSLTGAHA-------EVFV 2269
Query: 151 HIQVNDVNEYAPVFKEKSYKATVIEGKQY-DSILRVEAVDADCSPQFSQICSYEII---- 205
I V+D+N+ PVF ++SY T+ E S+++V A D+D P ++ SY++
Sbjct: 2270 DIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEP--NRGISYQMFGNHS 2327
Query: 206 TPDVPFTVDKD-GYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
F VD G I L+Y + Q+ + V A D G + DV+V + +
Sbjct: 2328 KSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDV 2380
Score = 55.5 bits (132), Expect = 2e-07
Identities = 44/156 (28%), Positives = 72/156 (46%), Gaps = 16/156 (10%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G ++ + LD E Y+ T+QA D G P + + TV+I V+DVN+ APVF
Sbjct: 3390 GEVKVTKLLDRETISGYTLTVQASDNGSPP------RVNTTTVNIDVSDVNDNAPVFSRG 3443
Query: 168 SYKATVIEGKQYD-SILRVEAVDADCS---PQFSQICSYEIIT--PDVPFTVDKDGYIKN 221
+Y + E K S+L++ D D S P F + I+T + F V+ G +
Sbjct: 3444 NYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPF----FFTIVTGNDEKAFEVNPQGVLLT 3499
Query: 222 TEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
+ + ++ Y L V D GK + + + I +
Sbjct: 3500 SSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRV 3535
Score = 55.1 bits (131), Expect = 3e-07
Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 10/159 (6%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
+D +TG + + EKLD E ++ T+ D VK++ A + + V+D N++
Sbjct: 1507 LDPATGS--LYTSEKLDHEAVHQHTLTVMVRD-----QDVPVKRNF-ARIVVNVSDTNDH 1558
Query: 161 APVFKEKSYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKD-GY 218
AP F SYK V E S +L+V A+D D + S E F +D G
Sbjct: 1559 APWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGS 1618
Query: 219 IKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
IK ++L+ + +Y L V A D G +E V+I +
Sbjct: 1619 IKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFV 1657
Score = 53.9 bits (128), Expect = 7e-07
Identities = 47/153 (30%), Positives = 73/153 (47%), Gaps = 11/153 (7%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
GVI + ++LD E Y T+ A D G P + ++ ++I+V DVN+ AP E
Sbjct: 1089 GVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIE------IYIEVEDVNDNAPQTSEP 1142
Query: 168 SYKATVIEGKQYD-SILRVEAVDADCSPQFSQICSYEIITPDVPFTV-DKDGYIKNT-EK 224
Y ++E D S++++EA D D S + P F++ K G I T K
Sbjct: 1143 VYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRK 1202
Query: 225 LNYGKEHQYKLTVTAYDCGK--KRATEDVLVKI 255
L+ ++ ++ L VT D G K V+VKI
Sbjct: 1203 LDREQQDEHILEVTVTDNGSPPKSTIARVIVKI 1235
Score = 53.5 bits (127), Expect = 9e-07
Identities = 46/157 (29%), Positives = 80/157 (50%), Gaps = 18/157 (11%)
Query: 97 DAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVND 156
++ V+D+ +G ++ ++ LD E K Y F+I A C + D + S V IQV D
Sbjct: 2749 ESFVIDRQSGR--LKLEKSLDHETTKWYQFSILAR-CTQ--DDHEMVAS--VDVSIQVKD 2801
Query: 157 VNEYAPVFKEKSYKATVIEGKQYDS-ILRVEAVDADCSP------QFSQICSYEIITPDV 209
N+ +PVF+ Y+A ++E S ++++ A DAD Q S E+I
Sbjct: 2802 ANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIE--- 2858
Query: 210 PFTVDKD-GYIKNTEKLNYGKEHQYKLTVTAYDCGKK 245
F ++ + G+I ++L++ K Y++ V A D G+K
Sbjct: 2859 SFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEK 2895
Score = 51.2 bits (121), Expect = 5e-06
Identities = 57/224 (25%), Positives = 96/224 (42%), Gaps = 30/224 (13%)
Query: 54 LLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFD---------AVVVDKS 104
LL ++ + + P ES+ V V+++ E+ I + D ++V D
Sbjct: 807 LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD 866
Query: 105 TGE-----GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNE 159
T GV+ LD ELQ ++S I+A D + + V + + DVN+
Sbjct: 867 TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAR----EEPQLFSTVVVKVSLEDVND 922
Query: 160 YAPVFKEKSYKATVIEGKQYDSILR-VEAVDADCSPQFSQICSYEIITPDVPFTVDK-DG 217
P F +Y+ V E +++ +EA D D Q Q+ + + F VDK G
Sbjct: 923 NPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLG-QSGQVRYSLLDHGEGNFDVDKLSG 981
Query: 218 YIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTC 261
++ ++L++ K+ Y LTV A D GK +S+ TC
Sbjct: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGK---------PVSLSSTC 1016
Score = 49.7 bits (117), Expect = 1e-05
Identities = 54/192 (28%), Positives = 87/192 (45%), Gaps = 29/192 (15%)
Query: 76 VTVTKEGEICGFKIHGQNVP--FDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDC 133
++V G F I G N FD VDK TG ++ + LD E + +Y+ T++A
Sbjct: 1380 ISVEPPGIPLWFDITGGNYDSHFD---VDKGTGTIIVA--KPLDAEQKSNYNLTVEA--- 1431
Query: 134 GKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDS-ILRVEAVDADC 192
DGT + V I+V D N++ P F Y+ + E ++ IL++ AVD D
Sbjct: 1432 ---TDGTTTILTQ---VFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE 1485
Query: 193 SPQFSQICSYEIITPDVPFTVDK------DGYIKNTEKLNYGKEHQYKLTVTA--YDCGK 244
+ Y + + P ++ K G + +EKL++ HQ+ LTV D
Sbjct: 1486 KNKL----IYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPV 1541
Query: 245 KRATEDVLVKIS 256
KR ++V +S
Sbjct: 1542 KRNFARIVVNVS 1553
Score = 48.1 bits (113), Expect = 4e-05
Identities = 52/164 (31%), Positives = 82/164 (50%), Gaps = 21/164 (12%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
+D STG I + LD E + FT+Q +D G + + A V + V D+N+
Sbjct: 1822 IDSSTG--AIHTVLSLDYEETSIFHFTVQVHDMGT----PRLFAEYAANVTVHVIDINDC 1875
Query: 161 APVFKEKSYKAT-VIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDV--PFTVD-KD 216
PVF + Y+A+ ++ + ++ V A DAD S FSQ+ Y I ++ F++D K
Sbjct: 1876 PPVFAKPLYEASLLLPTYKGVKVITVNATDAD-SSAFSQLI-YSITEGNIGEKFSMDYKT 1933
Query: 217 G--YIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIK 258
G ++NT +L +Y+LTV A D R VKI++K
Sbjct: 1934 GALTVQNTTQL----RSRYELTVRASD---GRFAGLTSVKINVK 1970
Score = 47.0 bits (110), Expect = 9e-05
Identities = 44/154 (28%), Positives = 76/154 (49%), Gaps = 16/154 (10%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G +++ LD E Q Y ++A D G + +A++ + + DVN+ AP F
Sbjct: 3077 GELKTSTPLDREEQAVYHLLVRATDGGG--------RFCQASIVLTLEDVNDNAPEFSAD 3128
Query: 168 SYKATVIEGKQYDSIL-RVEAVDADCSPQFSQICSYEII-TPDVPFTVDK-DGYIKNTEK 224
Y TV E + ++L RV+A DAD ++ Y +I + D F++++ G I+ +
Sbjct: 3129 PYAITVFENTEPGTLLTRVQATDADAG--LNRKILYSLIDSADGQFSINELSGIIQLEKP 3186
Query: 225 LNYGKEHQYKLTVTAYDCGKKR---ATEDVLVKI 255
L+ + Y L++ A D G R AT V+V +
Sbjct: 3187 LDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSV 3220
Score = 45.8 bits (107), Expect = 2e-04
Identities = 39/140 (27%), Positives = 64/140 (45%), Gaps = 12/140 (8%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G I + ++LD E + +Y + A D G+ ++ S A V + V DVN+ P F +
Sbjct: 2867 GWITTLKELDHEKRDNYQIKVVASDHGE-----KIQLSSTAIVDVTVTDVNDSPPRFTAE 2921
Query: 168 SYKATVIEGKQYDSILRV-EAVDADCSPQFSQICSYEIITPD-----VPFTVDKDGYIKN 221
YK TV E ++ + DAD S + ++ +Y I D T+ + +
Sbjct: 2922 IYKGTVSEDDPQGGVIAILSTTDAD-SEEINRQVTYFITGGDPLGQFAVETIQNEWKVYV 2980
Query: 222 TEKLNYGKEHQYKLTVTAYD 241
+ L+ K Y LT+TA D
Sbjct: 2981 KKPLDREKRDNYLLTITATD 3000
Score = 43.5 bits (101), Expect = 0.001
Identities = 39/131 (29%), Positives = 61/131 (46%), Gaps = 9/131 (6%)
Query: 116 LDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIE 175
L+ E++ Y+ ++A + TNV+ K V +QV D N+ P+F SY ++ E
Sbjct: 108 LNREVKDHYTLIVKALE-----KNTNVEARTK--VRVQVLDTNDLRPLFSPTSYSVSLPE 160
Query: 176 GKQY-DSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYK 234
SI RV A DAD S++ T D+ G I T +L+Y + Y+
Sbjct: 161 NTAIRTSIARVSATDADIGTNGEFYYSFKDRT-DMFAIHPTSGVIVLTGRLDYLETKLYE 219
Query: 235 LTVTAYDCGKK 245
+ + A D G K
Sbjct: 220 MEILAADRGMK 230
Score = 42.4 bits (98), Expect = 0.002
Identities = 56/213 (26%), Positives = 91/213 (42%), Gaps = 30/213 (14%)
Query: 95 PFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQV 154
P V+ E + K+ LD E + +Y TI A DGT S KA V ++V
Sbjct: 2963 PLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITA------TDGTF---SSKAIVEVKV 3013
Query: 155 NDVNEYAPVFKEKSYKAT----VIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVP 210
D N+ +PV ++ Y T V+ GK I+++ A DAD ++I + +
Sbjct: 3014 LDANDNSPVCEKTLYSDTIPEDVLPGK---LIMQISATDADIRSN-AEITYTLLGSGAEK 3069
Query: 211 FTVDKD-GYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWN 269
F ++ D G +K + L+ ++ Y L V A D G + +++ + +
Sbjct: 3070 FKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQASIVLTLE---------DVND 3120
Query: 270 NRIEYEPGTGALAVFPNIHLETCDEPVASVQAT 302
N E+ A+ VF N T + VQAT
Sbjct: 3121 NAPEFSADPYAITVFENTEPGTL---LTRVQAT 3150
Score = 37.7 bits (86), Expect = 0.053
Identities = 28/94 (29%), Positives = 48/94 (51%), Gaps = 9/94 (9%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
VD STG +I LD E + ++ ++A D G ++V V + V D+N+
Sbjct: 2335 VDSSTG--LISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDV------IVTVDVTDLNDN 2386
Query: 161 APVFKEKSYKATVIEGKQYDSILR-VEAVDADCS 193
P+F+++ Y+A + E + + V+A DAD S
Sbjct: 2387 PPLFEQQIYEARISEHAPHGHFVTCVKAYDADSS 2420
Score = 37.0 bits (84), Expect = 0.091
Identities = 37/138 (26%), Positives = 62/138 (44%), Gaps = 14/138 (10%)
Query: 106 GEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFK 165
GE ++ + +LD L K+Y T+ A D G + A V + + +N+ PVF+
Sbjct: 2133 GEISLKKQFELDT-LNKEYLVTVVAKDGGN--------PAFSAEVIVPITVMNKAMPVFE 2183
Query: 166 EKSYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEIITPDVPFTVD-KDGYIKNTE 223
+ Y A + E Q S ++ V+A + F I + P FT++ G I
Sbjct: 2184 KPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGD---PFSQFTINFNTGVINVIA 2240
Query: 224 KLNYGKEHQYKLTVTAYD 241
L++ YKL++ A D
Sbjct: 2241 PLDFEAHPAYKLSIRATD 2258
Score = 36.6 bits (83), Expect = 0.12
Identities = 53/234 (22%), Positives = 93/234 (39%), Gaps = 31/234 (13%)
Query: 31 VNKHKPWL-EPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKI 89
VN + P EP Y+ + EN KD + E+F+ + ++ +KI
Sbjct: 1132 VNDNAPQTSEPVYYPEIMENS------------PKDVSVVQIEAFDPDSSSNDKLM-YKI 1178
Query: 90 HGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKAT 149
N P + TG + + KLD E Q ++ + D G P KS A
Sbjct: 1179 TSGN-PQGFFSIHPKTGL-ITTTSRKLDREQQDEHILEVTVTDNGSPP------KSTIAR 1230
Query: 150 VHIQVNDVNEYAPVFKEKSYKATVIEGKQYD--------SILRVEAVDADCSPQFSQICS 201
V +++ D N+ P F +K YK + E ++ D + V A D D P S
Sbjct: 1231 VIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYS 1290
Query: 202 YEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKI 255
E F ++ + ++++ + E+ L++ A D G+ + + + I
Sbjct: 1291 IEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDI-LSIKAVDNGRPQKSSTTRLHI 1343
Score = 32.0 bits (71), Expect = 2.9
Identities = 35/142 (24%), Positives = 61/142 (42%), Gaps = 14/142 (9%)
Query: 119 ELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQ 178
+L+ Y T++A D G+ T+VK I V + E F + Y A V E
Sbjct: 1943 QLRSRYELTVRASD-GRFAGLTSVK--------INVKESKESHLKFTQDVYSAVVKENST 1993
Query: 179 YDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQ--YKLT 236
L V + A +P ++ Y I+ PD F + + + +T + +E Q + +
Sbjct: 1994 EAETLAV--ITAIGNP-INEPLFYHILNPDRRFKISRTSGVLSTTGTPFDREQQEAFDVV 2050
Query: 237 VTAYDCGKKRATEDVLVKISIK 258
V + K A V+VK+ ++
Sbjct: 2051 VEVTEEHKPSAVAHVVVKVIVE 2072
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 58.5 bits (140), Expect = 3e-08
Identities = 44/152 (28%), Positives = 71/152 (46%), Gaps = 7/152 (4%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G + LD E K+Y+ ++A D G+ P +NV V +QV D+N+ AP+F
Sbjct: 454 GALDVVSPLDYETTKEYTLRVRAQDGGR-PPLSNVS----GLVTVQVLDINDNAPIFVST 508
Query: 168 SYKATVIEGKQYD-SILRVEAVDADCSPQFSQICSYEIITPDVPFTVDK-DGYIKNTEKL 225
++ATV+E +L V+A+DAD + D PFT++ G+I +L
Sbjct: 509 PFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAEL 568
Query: 226 NYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
+ + Y V A D G T V +++
Sbjct: 569 DREEVDFYSFGVEARDHGTPALTASASVSVTV 600
Score = 57.8 bits (138), Expect = 5e-08
Identities = 62/233 (26%), Positives = 100/233 (42%), Gaps = 38/233 (16%)
Query: 24 GGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGE 83
GG VN + P+Y V EN L A+D D EGE
Sbjct: 168 GGRRKRNVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPD---------------EGE 212
Query: 84 ICGFKIHGQNVPFDA-----VVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPD 138
G + + FD+ +D TG + + E+LD E + + F + A D G
Sbjct: 213 -AGRLEYTMDALFDSRSNQFFSLDPVTG--AVTTAEELDRETKSTHVFRVTAQDHGMP-- 267
Query: 139 GTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYD-SILRVEAVDADCSPQFS 197
++S AT+ I V D N++ PVF+++ YK ++ E + +L V A D D P +
Sbjct: 268 ----RRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNAN 323
Query: 198 QICSYEII-----TPDVPFTVD-KDGYIKNTEKLNYGKEHQYKLTVTAYDCGK 244
+ Y ++ +P F +D + G I+ ++ + Y+LTV A D G+
Sbjct: 324 IL--YRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGR 374
Score = 53.9 bits (128), Expect = 7e-07
Identities = 45/141 (31%), Positives = 68/141 (48%), Gaps = 10/141 (7%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
GVIR++ +D E + Y T++A D G+ P +S A V + V D N+ AP F EK
Sbjct: 347 GVIRTRGPVDREEVESYQLTVEASDQGRDPG----PRSTTAAVFLSVEDDNDNAPQFSEK 402
Query: 168 SYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEIITPDV--PFTVD-KDGYIKNTE 223
Y V E + +LRV A D D + + Y I++ + F +D + G +
Sbjct: 403 RYVVQVREDVTPGAPVLRVTASDRDKGS--NAVVHYSIMSGNARGQFYLDAQTGALDVVS 460
Query: 224 KLNYGKEHQYKLTVTAYDCGK 244
L+Y +Y L V A D G+
Sbjct: 461 PLDYETTKEYTLRVRAQDGGR 481
Score = 53.9 bits (128), Expect = 7e-07
Identities = 58/230 (25%), Positives = 94/230 (40%), Gaps = 28/230 (12%)
Query: 32 NKHKPWLEPTYHGIVTENDNTVLLDPPLI-ALDKDAPLRFAESFEVTVTKEGEICGFKIH 90
N H+P + +++ + D LI A D+D E+ +T E I F+I
Sbjct: 706 NTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDT----GENARITYFMEDSIPQFRID 761
Query: 91 GQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATV 150
G + ++ +LD E Q Y+ I A D G +KS +
Sbjct: 762 ADT--------------GAVTTQAELDYEDQVSYTLAITARDNGIP------QKSDTTYL 801
Query: 151 HIQVNDVNEYAPVFKEKSYKATVIEG-KQYDSILRVEAVDADCSPQFSQICSYE-IITPD 208
I VNDVN+ AP F SY+ +V E + S+L++ A D D +++ D
Sbjct: 802 EILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGD 861
Query: 209 VPFTVDK-DGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
F V+ G ++ +L+ QY L A D G A + V +++
Sbjct: 862 GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTV 911
Score = 52.0 bits (123), Expect = 3e-06
Identities = 58/235 (24%), Positives = 99/235 (42%), Gaps = 33/235 (14%)
Query: 54 LLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDA--------------- 98
L+ ++ ++ +AP+ + F+ TV + + +H Q + DA
Sbjct: 490 LVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGH 549
Query: 99 -VVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDV 157
+ G G I +LD E YSF ++A D G + A+V + V DV
Sbjct: 550 DFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHG------TPALTASASVSVTVLDV 603
Query: 158 NEYAPVFKEKSYKATVIEGKQY-DSILRVEAVDADCSPQFSQICSYEIITPDV--PFTVD 214
N+ P F + Y + E S++ V AVD D + +Y+I + + F++
Sbjct: 604 NDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA----HSVITYQITSGNTRNRFSIT 659
Query: 215 KD---GYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQ 266
G + L+Y E QY L VTA D G ++ T ++V ++ T P +Q
Sbjct: 660 SQSGGGLVSLALPLDYKLERQYVLAVTASD-GTRQDTAQIVVNVTDANTHRPVFQ 713
Score = 47.4 bits (111), Expect = 7e-05
Identities = 38/159 (23%), Positives = 68/159 (42%), Gaps = 13/159 (8%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
+ +G G++ LD +L++ Y + A DGT + A + + V D N +
Sbjct: 658 ITSQSGGGLVSLALPLDYKLERQYVLAVTA------SDGT---RQDTAQIVVNVTDANTH 708
Query: 161 APVFKEKSYKATVIEGKQY-DSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKD-GY 218
PVF+ Y V E + +++ + A D D E P F +D D G
Sbjct: 709 RPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGA 766
Query: 219 IKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
+ +L+Y + Y L +TA D G + ++ ++I +
Sbjct: 767 VTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
Score = 42.7 bits (99), Expect = 0.002
Identities = 57/214 (26%), Positives = 90/214 (42%), Gaps = 28/214 (13%)
Query: 31 VNKHKP-WLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKI 89
VN + P +L +Y G V E+ + A D+D+ L + V T +G
Sbjct: 808 VNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGL----NGRVFYTFQG------- 856
Query: 90 HGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKAT 149
G + D +V S G++R+ +LD E Y A D G P T ++
Sbjct: 857 -GDDGDGDFIVESTS---GIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPME------ 906
Query: 150 VHIQVNDVNEYAPVFKEKSYKATVIEGKQYD-SILRVEAVDADCSPQFSQICSYEIITPD 208
V + V DVN+ PVF++ + V E ++ RV A D D +QI Y+I+ +
Sbjct: 907 VTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTN-AQI-MYQIVEGN 964
Query: 209 VPFTVDKD---GYIKNTEKLNYGKEHQYKLTVTA 239
+P D G + L+Y +Y L + A
Sbjct: 965 IPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA 998
Score = 35.4 bits (80), Expect = 0.26
Identities = 19/43 (44%), Positives = 27/43 (62%), Gaps = 3/43 (6%)
Query: 896 GKENEMDWD---DSALTITVNPMETYEDQHSSEEEEEEEEEEE 935
G++ + D D DS L++ + +Y HSS+ EEEEEEEEE
Sbjct: 2709 GQDQQHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEEEE 2751
>gi|11276081 protocadherin beta 8 precursor [Homo sapiens]
Length = 801
Score = 58.5 bits (140), Expect = 3e-08
Identities = 61/217 (28%), Positives = 88/217 (40%), Gaps = 23/217 (10%)
Query: 42 YHGIVTENDNTVLLDPPL--IALDKDAPLRF----AESFEVTVTKEGEICGFKIHGQNVP 95
Y +V NDN P + + +D+P+ F + +V GEI +
Sbjct: 230 YIEVVDVNDNAPEFQQPFYRVQISEDSPISFLVVKVSATDVDTGVNGEISYSLFQASDEI 289
Query: 96 FDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVN 155
VD TGE IR K++LD E + Y I+A D G S K TV IQV
Sbjct: 290 SKTFKVDFLTGE--IRLKKQLDFEKFQSYEVNIEARDAGGF--------SGKCTVLIQVI 339
Query: 156 DVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDK 215
DVN++AP ++ + + E + D D CS I D+PF +
Sbjct: 340 DVNDHAPEVTMSAFTSPIPENAPETVVALFSVSDLDSGENGKISCS---IQEDLPFLLKS 396
Query: 216 ---DGYIKNTE-KLNYGKEHQYKLTVTAYDCGKKRAT 248
+ Y TE L+ +Y +T+T D G R T
Sbjct: 397 SVGNFYTLLTETPLDRESRAEYNVTITVTDLGTPRLT 433
Score = 47.0 bits (110), Expect = 9e-05
Identities = 38/144 (26%), Positives = 66/144 (45%), Gaps = 10/144 (6%)
Query: 116 LDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIE 175
LD E + + T+ A D G P +S A V+I+V DVN+ AP F++ Y+ + E
Sbjct: 201 LDREEEAELRLTLTALDGGSPP------RSGTAQVYIEVVDVNDNAPEFQQPFYRVQISE 254
Query: 176 GKQYD-SILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKD---GYIKNTEKLNYGKEH 231
+++V A D D S + ++ T D G I+ ++L++ K
Sbjct: 255 DSPISFLVVKVSATDVDTGVNGEISYSLFQASDEISKTFKVDFLTGEIRLKKQLDFEKFQ 314
Query: 232 QYKLTVTAYDCGKKRATEDVLVKI 255
Y++ + A D G VL+++
Sbjct: 315 SYEVNIEARDAGGFSGKCTVLIQV 338
Score = 39.7 bits (91), Expect = 0.014
Identities = 51/210 (24%), Positives = 92/210 (43%), Gaps = 28/210 (13%)
Query: 62 LDKDAPLRFAESFEVTVTKEGE----ICGFKIHGQNVPFDAVVVDKSTGEG-VIRSKEKL 116
+ ++AP F V+ GE C + +++PF ++ S G + ++ L
Sbjct: 357 IPENAPETVVALFSVSDLDSGENGKISCSIQ---EDLPF---LLKSSVGNFYTLLTETPL 410
Query: 117 DCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEG 176
D E + +Y+ TI D G T++ + + V+DVN+ AP F + SY V E
Sbjct: 411 DRESRAEYNVTITVTDLGTPRLTTHLNMT------VLVSDVNDNAPAFTQTSYTLFVREN 464
Query: 177 KQYD-SILRVEAVDADCSPQFSQICSYEIITPDVP-------FTVDKD-GYIKNTEKLNY 227
I V A D D S +Q+ +Y ++ P P +++ D G++ L+Y
Sbjct: 465 NSPALHIGSVSATDRD-SGTNAQV-TYSLLPPQDPHLPLASLVSINTDNGHLFALRSLDY 522
Query: 228 GKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
++ V A D G + + LV++ +
Sbjct: 523 EALQAFEFRVGASDRGSPALSSEALVRVLV 552
>gi|157426847 protocadherin 19 isoform a [Homo sapiens]
Length = 1101
Score = 57.4 bits (137), Expect = 6e-08
Identities = 61/207 (29%), Positives = 88/207 (42%), Gaps = 27/207 (13%)
Query: 61 ALDKDAPLRFAESFEVTVTKEGEICGFKI--HGQNVPFDAVVVDKSTGEGVIRSKEKLDC 118
A D D+ +++E+T E+ G +I G F +VV+KS LD
Sbjct: 153 AYDPDSGSFGVQTYELT---PNELFGLEIKTRGDGSRFAELVVEKS-----------LDR 198
Query: 119 ELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQ 178
E Q YSF I A D G P V S I+V D N+ PVF E +Y +V E
Sbjct: 199 ETQSHYSFRITALDGGDPPRLGTVGLS------IKVTDSNDNNPVFSESTYAVSVPENSP 252
Query: 179 YDS-ILRVEAVDADCSPQFSQICSYEIITPDVP---FTVDK-DGYIKNTEKLNYGKEHQY 233
++ ++R+ A D D + S+ D F +D G + T L+Y + H Y
Sbjct: 253 PNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVY 312
Query: 234 KLTVTAYDCGKKRATEDVLVKISIKPT 260
+L V A D G V +S+ T
Sbjct: 313 ELDVQAKDLGPNSIPAHCKVTVSVLDT 339
Score = 39.7 bits (91), Expect = 0.014
Identities = 53/247 (21%), Positives = 91/247 (36%), Gaps = 49/247 (19%)
Query: 32 NKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHG 91
+ H + +P Y IV EN+ + A D D L + S+++ ++ ++ F
Sbjct: 448 DNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVF---- 503
Query: 92 QNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVH 151
V + G I + + E K + F + A D G +N ATV
Sbjct: 504 -------TYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSN------ATVR 550
Query: 152 IQVNDVNEYAPVFKEK-----------------SYKATVIEGKQYDSILRVEAVDADCSP 194
+ + DVN+ PV Y TV++ + YD
Sbjct: 551 VIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRV------- 603
Query: 195 QFSQICSYEIITPDVPF-TVDK-DGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVL 252
+Y++ D F +D+ +G ++ T + Y+L V A+D GK + L
Sbjct: 604 ------TYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASAL 657
Query: 253 VKISIKP 259
V I + P
Sbjct: 658 VLIYLSP 664
Score = 32.0 bits (71), Expect = 2.9
Identities = 41/152 (26%), Positives = 63/152 (41%), Gaps = 17/152 (11%)
Query: 115 KLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVI 174
+LD E Y+ TIQA D G + +S K+ + + D N+ P F + Y+ V
Sbjct: 410 RLDREQHDQYNLTIQARD-----GGVPMLQSAKSFT-VLITDENDNHPHFSKPYYQVIVQ 463
Query: 175 EGKQYDS-ILRVEAVDADCSPQFSQICSYEII---TPDVP-FTV----DKDGYIKNTEKL 225
E + +L V A D D S SY+I+ D+P FT G I
Sbjct: 464 ENNTPGAYLLSVSARDPDLGLNGS--VSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSF 521
Query: 226 NYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
N+ + ++ V A D G + V++ I
Sbjct: 522 NHEQTKAFEFKVLAKDGGLPSLQSNATVRVII 553
>gi|157426845 protocadherin 19 isoform b [Homo sapiens]
Length = 1100
Score = 57.4 bits (137), Expect = 6e-08
Identities = 61/207 (29%), Positives = 88/207 (42%), Gaps = 27/207 (13%)
Query: 61 ALDKDAPLRFAESFEVTVTKEGEICGFKI--HGQNVPFDAVVVDKSTGEGVIRSKEKLDC 118
A D D+ +++E+T E+ G +I G F +VV+KS LD
Sbjct: 153 AYDPDSGSFGVQTYELT---PNELFGLEIKTRGDGSRFAELVVEKS-----------LDR 198
Query: 119 ELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQ 178
E Q YSF I A D G P V S I+V D N+ PVF E +Y +V E
Sbjct: 199 ETQSHYSFRITALDGGDPPRLGTVGLS------IKVTDSNDNNPVFSESTYAVSVPENSP 252
Query: 179 YDS-ILRVEAVDADCSPQFSQICSYEIITPDVP---FTVDK-DGYIKNTEKLNYGKEHQY 233
++ ++R+ A D D + S+ D F +D G + T L+Y + H Y
Sbjct: 253 PNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVY 312
Query: 234 KLTVTAYDCGKKRATEDVLVKISIKPT 260
+L V A D G V +S+ T
Sbjct: 313 ELDVQAKDLGPNSIPAHCKVTVSVLDT 339
Score = 39.7 bits (91), Expect = 0.014
Identities = 53/247 (21%), Positives = 91/247 (36%), Gaps = 49/247 (19%)
Query: 32 NKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHG 91
+ H + +P Y IV EN+ + A D D L + S+++ ++ ++ F
Sbjct: 448 DNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVF---- 503
Query: 92 QNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVH 151
V + G I + + E K + F + A D G +N ATV
Sbjct: 504 -------TYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSN------ATVR 550
Query: 152 IQVNDVNEYAPVFKEK-----------------SYKATVIEGKQYDSILRVEAVDADCSP 194
+ + DVN+ PV Y TV++ + YD
Sbjct: 551 VIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRV------- 603
Query: 195 QFSQICSYEIITPDVPF-TVDK-DGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVL 252
+Y++ D F +D+ +G ++ T + Y+L V A+D GK + L
Sbjct: 604 ------TYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASAL 657
Query: 253 VKISIKP 259
V I + P
Sbjct: 658 VLIYLSP 664
Score = 32.0 bits (71), Expect = 2.9
Identities = 41/152 (26%), Positives = 63/152 (41%), Gaps = 17/152 (11%)
Query: 115 KLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVI 174
+LD E Y+ TIQA D G + +S K+ + + D N+ P F + Y+ V
Sbjct: 410 RLDREQHDQYNLTIQARD-----GGVPMLQSAKSFT-VLITDENDNHPHFSKPYYQVIVQ 463
Query: 175 EGKQYDS-ILRVEAVDADCSPQFSQICSYEII---TPDVP-FTV----DKDGYIKNTEKL 225
E + +L V A D D S SY+I+ D+P FT G I
Sbjct: 464 ENNTPGAYLLSVSARDPDLGLNGS--VSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSF 521
Query: 226 NYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
N+ + ++ V A D G + V++ I
Sbjct: 522 NHEQTKAFEFKVLAKDGGLPSLQSNATVRVII 553
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 57.4 bits (137), Expect = 6e-08
Identities = 48/160 (30%), Positives = 77/160 (48%), Gaps = 13/160 (8%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
+D+ TG+ + + LD E + Y I+A D G P + K + I V DVN+
Sbjct: 2614 IDQLTGQ--VSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEK------LDITVLDVNDN 2665
Query: 161 APVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDV--PFTVD-KDG 217
AP+FKE + + ++E IL V A+D D P YEI+ ++ F+++ G
Sbjct: 2666 APIFKEDPFISEILENLSPRKILTVSAMDKDSGPNGQ--LDYEIVNGNMENSFSINHATG 2723
Query: 218 YIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
I++ L+ K Y LT+ + D G + V V I+I
Sbjct: 2724 EIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINI 2763
Score = 54.7 bits (130), Expect = 4e-07
Identities = 46/144 (31%), Positives = 65/144 (45%), Gaps = 13/144 (9%)
Query: 105 TGEGV---IRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYA 161
+GEG + SK LD E+ Y ++ D G+ K+ V++ V D+N+
Sbjct: 194 SGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEP------KRRGYLQVNVTVQDINDNP 247
Query: 162 PVFKEKSYKATVIEGKQY-DSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKD-GYI 219
PVF Y+A V E S+L+V A DAD Y + PF +D + G I
Sbjct: 248 PVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNAD--IRYRLQDEGTPFQMDPETGLI 305
Query: 220 KNTEKLNYGKEHQYKLTVTAYDCG 243
E L++ QY LTV A D G
Sbjct: 306 TVREPLDFEARRQYSLTVQAMDRG 329
Score = 52.8 bits (125), Expect = 2e-06
Identities = 43/160 (26%), Positives = 75/160 (46%), Gaps = 11/160 (6%)
Query: 104 STGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPV 163
++ G++ + LD EL + + TI A D G V ++ +V + V DVN+ +PV
Sbjct: 3140 NSSTGILTLAKALDYELCQKHEMTISAIDGGW------VARTGYCSVTVNVIDVNDNSPV 3193
Query: 164 FKEKSYKATVIE-GKQYDSILRVEAVDADCSPQFSQICSYEIITPDVP-FTVDKD-GYIK 220
F Y TV+E +++ + A DAD + + +Y + + D F +D + G I
Sbjct: 3194 FLSDDYFPTVLENAPSGTTVIHLNATDADSGT--NAVIAYTVQSSDSDLFVIDPNTGVIT 3251
Query: 221 NTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPT 260
L++ + Y LTV A++ + V I +K T
Sbjct: 3252 TQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGT 3291
Score = 52.0 bits (123), Expect = 3e-06
Identities = 44/145 (30%), Positives = 66/145 (45%), Gaps = 12/145 (8%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G I + LD E Y T+QA D G P ++ +TV I + D+N++ PVF+
Sbjct: 2209 GAITVAKPLDREKTPTYHLTVQATDRGSTP------RTDTSTVSIVLLDINDFVPVFELS 2262
Query: 168 SYKATVIE--GKQYDSILRVEAVDADCSPQFSQICSYEII--TPDVPFTVDKDGYIKNTE 223
Y V E G +IL+V A D D + SY + D FT+ G + T+
Sbjct: 2263 PYSVNVPENLGTLPRTILQVVARDDDRGS--NSKLSYVLFGGNEDNAFTLSASGELGVTQ 2320
Query: 224 KLNYGKEHQYKLTVTAYDCGKKRAT 248
L+ + ++ L +TA D G T
Sbjct: 2321 SLDRETKERFVLMITATDSGSPALT 2345
Score = 50.8 bits (120), Expect = 6e-06
Identities = 40/136 (29%), Positives = 63/136 (46%), Gaps = 11/136 (8%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
GV LD E+Q+ Y T++A D G T ++ V+ + DVN+ P+F
Sbjct: 1896 GVFNLTRLLDYEVQQYYILTVRAED--GGGQFTTIR------VYFNILDVNDNPPIFSLN 1947
Query: 168 SYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDV--PFTVDKDGYIKNTEKL 225
SY +++E S + V V D + +Y I + D FTVDK+G +K + L
Sbjct: 1948 SYSTSLMENLPVGSTVLVFNV-TDADDGINSQLTYSIASGDSLGQFTVDKNGVLKVLKAL 2006
Query: 226 NYGKEHQYKLTVTAYD 241
+ + Y L V +D
Sbjct: 2007 DRESQSFYNLVVQVHD 2022
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/143 (30%), Positives = 62/143 (43%), Gaps = 21/143 (14%)
Query: 124 YSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIE-GKQYDSI 182
+SFT+ A D G +ATVH+ + D+N+ AP F + Y+AT+ E +
Sbjct: 1175 FSFTVIATD-----QGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQV 1229
Query: 183 LRVEAVDADCSPQFSQICSYEII--TPDVPFTVDK-DGYIKNTEKLNYGKEHQYKLTVTA 239
LRV A D D + + Y II + F +D G + KL+Y Y L + A
Sbjct: 1230 LRVSASDVD--EGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQA 1287
Query: 240 YDCGKKRATEDVLVKISIKPTCT 262
D G I + TCT
Sbjct: 1288 VDSG----------TIPLNSTCT 1300
Score = 47.8 bits (112), Expect = 5e-05
Identities = 44/172 (25%), Positives = 75/172 (43%), Gaps = 16/172 (9%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
+D ++G+ + K LD E YS IQA D G P + T++I + D N+
Sbjct: 1260 IDSTSGQVTLIGK--LDYEATPAYSLVIQAVDSGTIPLNST------CTLNIDILDENDN 1311
Query: 161 APVFKEKSYKATVIEGKQYDSILR-VEAVDADCSPQFSQICSYEIITPDVPFTVDKD-GY 218
P F + + V+E + ++ V A D+D S F++ + G
Sbjct: 1312 TPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGS 1371
Query: 219 IKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIK------PTCTPG 264
I +KL++ + YKL +TA D G+ + + V I ++ P+ PG
Sbjct: 1372 IFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPG 1423
Score = 46.6 bits (109), Expect = 1e-04
Identities = 59/236 (25%), Positives = 100/236 (42%), Gaps = 34/236 (14%)
Query: 46 VTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICG--FKIH------GQNVPFD 97
V + ++V+L + ++ ++P+ S+EVT+++ + FK+ G N
Sbjct: 973 VPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIA 1032
Query: 98 AVVVDKSTGE-------GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATV 150
+ + +TG+ G + K +LD ELQ Y + A D P V V
Sbjct: 1033 YTIAEGNTGDAFGIFPDGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVN------V 1086
Query: 151 HIQVNDVNEYAPVFKEKSYKATVIEGKQYDSIL-RVEAVDADCSPQFSQICSYEIITPDV 209
+ + DVN+ P+F +Y E ++ S + +V AVD D P S+E++ PD
Sbjct: 1087 TVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDF 1146
Query: 210 PFTVDKDGYIKNTEKLNYGKEHQ------YKLTVTAYDCG-----KKRATEDVLVK 254
G I NT + + + + TV A D G K +AT V +K
Sbjct: 1147 ELHA-ISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMK 1201
Score = 45.8 bits (107), Expect = 2e-04
Identities = 39/140 (27%), Positives = 66/140 (47%), Gaps = 12/140 (8%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G I L +L +++ T+ A D G P S +ATVHI V + N + P F +
Sbjct: 3039 GWISVASSLISDLNQNFFITVTAKDKGNPP------LSSQATVHITVTEENYHTPEFSQS 3092
Query: 168 SYKATVIEGKQYDSILR-VEAVDADCSPQFSQICSYEIITPDVP--FTVDKD-GYIKNTE 223
AT+ E SI+R V A D D + + + Y I + + F ++ G + +
Sbjct: 3093 HMSATIPESHSIGSIVRTVSARDRDAA--MNGLIKYSISSGNEEGIFAINSSTGILTLAK 3150
Query: 224 KLNYGKEHQYKLTVTAYDCG 243
L+Y ++++T++A D G
Sbjct: 3151 ALDYELCQKHEMTISAIDGG 3170
Score = 45.1 bits (105), Expect = 3e-04
Identities = 43/156 (27%), Positives = 69/156 (44%), Gaps = 11/156 (7%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G + + LD E Q YS + A D G P +S A +++ + D+N+ +PVF
Sbjct: 639 GRLSTISSLDREEQAFYSLLVLATDLGSPP------QSSMARINVSLLDINDNSPVFYPV 692
Query: 168 SYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEIITPD-VPFTVD-KDGYIKNTEK 224
Y A + E + S I V A D D + Y I D F V+ + G I
Sbjct: 693 QYFAHIKENEPGGSYITTVSATDPDLGT--NGTVKYSISAGDRSRFQVNAQSGVISTRMA 750
Query: 225 LNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPT 260
L+ ++ Y+L + A D G ++ +V I++ T
Sbjct: 751 LDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDT 786
Score = 45.1 bits (105), Expect = 3e-04
Identities = 53/201 (26%), Positives = 88/201 (43%), Gaps = 31/201 (15%)
Query: 65 DAPLRFAESFEVTVTKEGEICGFKI--------HGQNVPFDAVVV-----DKSTGE---- 107
D P+ F + +T+ KEGE G + G P + +V +K+ G
Sbjct: 1625 DGPV-FTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTI 1683
Query: 108 ----GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPV 163
G+I++ LD E Q + + Y K T ++ +A V I + D+N+ PV
Sbjct: 1684 GRHTGIIQTAAILDRE-QGACLYLVDVYAIEKS---TAFPRTQRAEVEITLQDINDNPPV 1739
Query: 164 FKEKSYKATVIEG-KQYDSILRVEAVDADCSPQFSQICSYEIIT-PDVPFTVD-KDGYIK 220
F TV E I+++ A+DAD + + +Y II+ D F +D + G +
Sbjct: 1740 FPTDMLDLTVEENIGDGSKIMQLTAMDAD--EGANALVTYTIISGADDSFRIDPESGDLI 1797
Query: 221 NTEKLNYGKEHQYKLTVTAYD 241
T +L+ + +Y L V A D
Sbjct: 1798 ATRRLDRERRSKYSLLVRADD 1818
Score = 43.5 bits (101), Expect = 0.001
Identities = 48/170 (28%), Positives = 78/170 (45%), Gaps = 12/170 (7%)
Query: 92 QNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVH 151
Q+ D V+D +TG VI ++ LD E ++ Y T++A++ PD ++ ATV+
Sbjct: 3234 QSSDSDLFVIDPNTG--VITTQGFLDFETKQSYHLTVKAFNV---PDE---ERCSFATVN 3285
Query: 152 IQVNDVNEYAPVFKEKSYKATVIEGKQYDSIL-RVEAVDADCSPQFSQICSYEIITPDVP 210
IQ+ NEY P F K Y + E +I+ V A D D +
Sbjct: 3286 IQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKG 3345
Query: 211 FTVD-KDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRAT--EDVLVKISI 257
F ++ K G I + L+ KE + L V A + G R ++V V +++
Sbjct: 3346 FQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTV 3395
Score = 42.7 bits (99), Expect = 0.002
Identities = 48/167 (28%), Positives = 73/167 (43%), Gaps = 23/167 (13%)
Query: 87 FKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSH 146
+++ + PF +D TG +I +E LD E ++ YS T+QA D G P T
Sbjct: 287 YRLQDEGTPFQ---MDPETG--LITVREPLDFEARRQYSLTVQAMDRGV-PSLTG----- 335
Query: 147 KATVHIQVNDVNEYAPVFKEKSYKAT-----VIEGKQYDSILRVEAVDADCSPQFSQICS 201
+A IQ+ DVN+ PV K + + AT V E Q +++ + V SP + S
Sbjct: 336 RAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNIS 395
Query: 202 YEII--TPDVPFTVDKD-----GYIKNTEKLNYGKEHQYKLTVTAYD 241
+I+ F V IK L+ + Y LTV+ D
Sbjct: 396 VQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSD 442
Score = 42.7 bits (99), Expect = 0.002
Identities = 45/155 (29%), Positives = 68/155 (43%), Gaps = 12/155 (7%)
Query: 105 TGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVF 164
T +G +R +LD E +Y+ T+ A D G+ S V + V D+N+ P+F
Sbjct: 2101 TIDGEVRLTGELDREEVSNYTLTVVATDKGQP------SLSSSTEVVVMVLDINDNNPIF 2154
Query: 165 KEKSYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEIITPDV--PFTVDK-DGYIK 220
+ YK + E + I++V A D D Q+ Y I+ + F +D G I
Sbjct: 2155 AQALYKVEINENTLTGTDIIQVFAADGDEGTN-GQV-RYGIVNGNTNQEFRIDSVTGAIT 2212
Query: 221 NTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKI 255
+ L+ K Y LTV A D G T+ V I
Sbjct: 2213 VAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSI 2247
Score = 42.7 bits (99), Expect = 0.002
Identities = 43/157 (27%), Positives = 68/157 (43%), Gaps = 15/157 (9%)
Query: 105 TGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVF 164
+ G + + LD E ++ + I A D G P T T+++ V+DVN+ P F
Sbjct: 2311 SASGELGVTQSLDRETKERFVLMITATDSGS-PALTGT-----GTINVIVDDVNDNVPTF 2364
Query: 165 KEKSYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEIITPDVPFTVD-KDGYIKNT 222
K+Y T+ E + +L V A DAD S II + FT++ G I +
Sbjct: 2365 ASKAYFTTIPEDAPTGTDVLLVNASDADASKN----AVIRIIGGNSQFTINPSTGQIITS 2420
Query: 223 EKLNYGKEHQYKLTVTAYDCGKKR---ATEDVLVKIS 256
L+ + Y L V D G ++ VLV ++
Sbjct: 2421 ALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVT 2457
Score = 40.8 bits (94), Expect = 0.006
Identities = 38/148 (25%), Positives = 61/148 (41%), Gaps = 13/148 (8%)
Query: 46 VTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKST 105
V EN + L D D+P + V + E F++ VP
Sbjct: 367 VDENAQVGTVVALLTVTDADSPAANG-NISVQILGGNEQRHFEVQSSKVP---------- 415
Query: 106 GEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVK-KSHKATVHIQVNDVNEYAPVF 164
+I+ LD E Y+ T+ D P G V+ +S A++ I VND+N++ PVF
Sbjct: 416 NLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVF 475
Query: 165 KEKSYKATVIEGKQYDS-ILRVEAVDAD 191
++ Y+ + E S + + A D D
Sbjct: 476 SQQVYRVNLSEEAPPGSYVSGISATDGD 503
Score = 39.7 bits (91), Expect = 0.014
Identities = 44/154 (28%), Positives = 67/154 (43%), Gaps = 15/154 (9%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
GVI ++ LD E + Y I A DG N++ ++A V I V D + PVF +
Sbjct: 743 GVISTRMALDREEKTAYQLQIVA------TDGGNLQSPNQAIVTITVLDTQDNPPVFSQV 796
Query: 168 SYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVP--FTVDK-DGYIKNTEK 224
+Y V E V +V A S I SY I T D F +++ G +
Sbjct: 797 AYSFVVFENVALG--YHVGSVSASTMDLNSNI-SYLITTGDQKGMFAINQVTGQLTTANV 853
Query: 225 LNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIK 258
++ ++ Y+L V A T D +V I++K
Sbjct: 854 IDREEQSFYQLKVVA---SGGTVTGDTMVNITVK 884
Score = 37.4 bits (85), Expect = 0.069
Identities = 29/114 (25%), Positives = 52/114 (45%), Gaps = 5/114 (4%)
Query: 145 SHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYE 203
S + + V+DVN+ +PVF + SY+ T+ E + +S +V+A D D +
Sbjct: 977 SSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIA 1036
Query: 204 IITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
F + DG + +L+ + +Y L V A D RA E + +++
Sbjct: 1037 EGNTGDAFGIFPDGQLYIKSELDRELQDRYVLMVVASD----RAVEPLSATVNV 1086
Score = 36.6 bits (83), Expect = 0.12
Identities = 41/162 (25%), Positives = 67/162 (41%), Gaps = 15/162 (9%)
Query: 97 DAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVND 156
D+ +D +G+ + + +LD E + YS ++A D + D ++I V+D
Sbjct: 1785 DSFRIDPESGDLI--ATRRLDRERRSKYSLLVRADDGLQSSD---------MRINITVSD 1833
Query: 157 VNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPD---VPFTV 213
VN++ P F Y + E S++ D S +I +Y + D + F
Sbjct: 1834 VNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEI-TYIVNEDDEDGIFFLN 1892
Query: 214 DKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKI 255
G T L+Y + Y LTV A D G + T V I
Sbjct: 1893 PITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNI 1934
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 54.7 bits (130), Expect = 4e-07
Identities = 26/58 (44%), Positives = 34/58 (58%)
Query: 915 METYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQGDPQNATRQQQL 972
+E ++ EEEEE+EEEEE E+ EEED+ E E EEEE Q P T+ Q +
Sbjct: 1062 LELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPRLTKPQSV 1119
Score = 47.0 bits (110), Expect = 9e-05
Identities = 26/79 (32%), Positives = 44/79 (55%), Gaps = 5/79 (6%)
Query: 897 KENEMDWDDSALTITVNPMETYED-----QHSSEEEEEEEEEEESEDGEEEDDITSAESE 951
+EN + + ++ +P E ED + EEEEEEEEEEE E+GEEE+ + E +
Sbjct: 1322 EENRREETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKD 1381
Query: 952 SSEEEEGEQGDPQNATRQQ 970
+ E+ +P+ +T ++
Sbjct: 1382 PDGAKSQEKEEPEISTEKE 1400
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/85 (35%), Positives = 38/85 (44%), Gaps = 19/85 (22%)
Query: 912 VNPMETYEDQHSSEEEEEEEEEEESEDG-------------EEEDDITSAESESS----- 953
+ P E E++ EEEEEEEE EE E G E+E+ S E E S
Sbjct: 1348 IKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLDD 1407
Query: 954 -EEEEGEQGDPQNATRQQQLEWDDS 977
EEEE E +P + + DDS
Sbjct: 1408 HEEEEEEDEEPSHNEDHDADDEDDS 1432
Score = 34.7 bits (78), Expect = 0.45
Identities = 18/66 (27%), Positives = 29/66 (43%), Gaps = 2/66 (3%)
Query: 891 RDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAES 950
+D D K E + + ++ +D EEE+EE E D ++EDD +
Sbjct: 1380 KDPDGAKSQEKE--EPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESA 1437
Query: 951 ESSEEE 956
E +EE
Sbjct: 1438 EVEKEE 1443
Score = 33.1 bits (74), Expect = 1.3
Identities = 22/73 (30%), Positives = 35/73 (47%), Gaps = 5/73 (6%)
Query: 892 DQDTGKENEMDWDDSALTITVNPMETYEDQHSS-----EEEEEEEEEEESEDGEEEDDIT 946
+++ G E D D + P + E + S+ EEEEEE+EE + + DD
Sbjct: 1371 EEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDED 1430
Query: 947 SAESESSEEEEGE 959
+ ES+E E+ E
Sbjct: 1431 DSHMESAEVEKEE 1443
Score = 31.6 bits (70), Expect = 3.8
Identities = 13/45 (28%), Positives = 24/45 (53%)
Query: 929 EEEEEEESEDGEEEDDITSAESESSEEEEGEQGDPQNATRQQQLE 973
E +E E+ EEED+ E E EE+E E+ + + ++ ++
Sbjct: 1063 ELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQ 1107
Score = 31.2 bits (69), Expect = 5.0
Identities = 17/61 (27%), Positives = 29/61 (47%)
Query: 919 EDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQGDPQNATRQQQLEWDDST 978
ED ++ EEEEEE+E E+ D + E E E+ + + ++ LE ++
Sbjct: 1400 EDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLENQETF 1459
Query: 979 L 979
L
Sbjct: 1460 L 1460
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 54.7 bits (130), Expect = 4e-07
Identities = 82/345 (23%), Positives = 132/345 (38%), Gaps = 57/345 (16%)
Query: 31 VNKHKPWL-EPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKI 89
VN+H+P + Y V EN + + A D+D PL ++ ++ F I
Sbjct: 3314 VNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLN--SDITYSLIGGNQLGHFTI 3371
Query: 90 HGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKAT 149
H + +G ++ + LD E YS ++A D G+ P H+ T
Sbjct: 3372 HPK--------------KGELQVAKALDREQASSYSLKLRATDSGQPP-------LHEDT 3410
Query: 150 -VHIQVNDVNEYAPVFKEKSYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEIITP 207
+ IQV DVN+ P F + +Y TV E S +L++ D D SP+ S+ I
Sbjct: 3411 DIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPD-SPENGPPYSFRITKG 3469
Query: 208 D--VPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGW 265
+ F V DG++ E L+ + Y+L + A D G + V++ +
Sbjct: 3470 NNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHV-------- 3521
Query: 266 QGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQATVELETSHIGK--GCDRDTYSEKS 323
+ Y P L +F + + E + +GK DRD +
Sbjct: 3522 ---TEQSHYAPSALPLEIFITVGED-------------EFQGGMVGKIHATDRDPQDTLT 3565
Query: 324 LHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSDQVFEFNGT 368
G + +P G + GLP GH S V +GT
Sbjct: 3566 YSLAEEETLGRHFSVGAPDGKIIAAQGLP--RGHYSFNVTVSDGT 3608
Score = 53.1 bits (126), Expect = 1e-06
Identities = 47/158 (29%), Positives = 80/158 (50%), Gaps = 16/158 (10%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
GVI+ ++ +D E K Y + A+ C + D ++ +V+IQV DVN+ PVF+
Sbjct: 2747 GVIKVRKPMDHESTKLYQIDVMAH-CLQNTDVVSL-----VSVNIQVGDVNDNRPVFEAD 2800
Query: 168 SYKATVIEGKQY-DSILRVEAVDADCSPQFSQICSYEIITPDVP-----FTVDKD-GYIK 220
YKA + E S+++V A+D D + + Q+ SY + F +D + G+I
Sbjct: 2801 PYKAVLTENMPVGTSVIQVTAIDKD-TGRDGQV-SYRLSADPGSNVHELFAIDSESGWIT 2858
Query: 221 NTEKLNYGKEHQYKLTVTAYDCGKK-RATEDVLVKISI 257
++L+ Y V AYD G+ + + LV++SI
Sbjct: 2859 TLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSI 2896
Score = 48.1 bits (113), Expect = 4e-05
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 15/156 (9%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
GV+ LD E + + FT++A D G +ATV + V DVN+ P F +
Sbjct: 2223 GVLTVTGPLDYESKTKHVFTVRATDTALG-------SFSEATVEVLVEDVNDNPPTFSQL 2275
Query: 168 SYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEIIT--PDVP--FTVD-KDGYIKN 221
Y ++ EG + ++++ A D D ++ SY+I+ DV F ++ G +
Sbjct: 2276 VYTTSISEGLPAQTPVIQLLASDQDSGR--NRDVSYQIVEDGSDVSKFFQINGSTGEMST 2333
Query: 222 TEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
++L+Y + + + V A D G T + LV +++
Sbjct: 2334 VQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNV 2369
Score = 45.8 bits (107), Expect = 2e-04
Identities = 44/154 (28%), Positives = 68/154 (44%), Gaps = 12/154 (7%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G++ LD E Y +I+ C + + S TV + + DVNE+ P F +
Sbjct: 3271 GILYVNASLDFETSPKYFLSIE---CSRKSSSS---LSDVTTVMVNITDVNEHRPQFPQD 3324
Query: 168 SYKATVIEGKQY-DSILRVEAVDADCSPQFSQICSYEIITPDV--PFTV-DKDGYIKNTE 223
Y V+E D IL V A D D P S I +Y +I + FT+ K G ++ +
Sbjct: 3325 PYSTRVLENALVGDVILTVSATDED-GPLNSDI-TYSLIGGNQLGHFTIHPKKGELQVAK 3382
Query: 224 KLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
L+ + Y L + A D G+ ED + I +
Sbjct: 3383 ALDREQASSYSLKLRATDSGQPPLHEDTDIAIQV 3416
Score = 43.5 bits (101), Expect = 0.001
Identities = 49/172 (28%), Positives = 83/172 (48%), Gaps = 19/172 (11%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
++ STGE + + ++LD E Q+ + ++A D G P + + V + V+D+N+
Sbjct: 2324 INGSTGE--MSTVQELDYEAQQHFHVKVRAMDKGDPP------LTGETLVVVNVSDINDN 2375
Query: 161 APVFKEKSYKATVIE-GKQYDSILRVEAVDADCSPQFSQICSYEIIT--PDVPFTVDKDG 217
P F++ Y+A V E +L+V+A+D D S S++ Y I++ D F ++
Sbjct: 2376 PPEFRQPQYEANVSELATCGHLVLKVQAIDPD-SRDTSRL-EYLILSGNQDRHFFINSSS 2433
Query: 218 YIKNTEKLNYGKEH---QYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQ 266
I N K+H Y L V A D G RAT V + + +P +Q
Sbjct: 2434 GI--ISMFNLCKKHLDSSYNLRVGASD-GVFRATVPVYINTTNANKYSPEFQ 2482
Score = 37.7 bits (86), Expect = 0.053
Identities = 33/125 (26%), Positives = 55/125 (44%), Gaps = 6/125 (4%)
Query: 138 DGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQ-YDSILRVEAVDADCSPQF 196
D ++ + V + + DVN+ P FK Y + +G + D + +V A D D
Sbjct: 2044 DNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGT-- 2101
Query: 197 SQICSYEIITPDVPFTVDKD-GYIKNTEKLNYGKEHQYKLTVTAYDCG--KKRATEDVLV 253
+ +YE F +D G I + +Y ++Y L V A D G ++ E+VLV
Sbjct: 2102 NGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLV 2161
Query: 254 KISIK 258
+ K
Sbjct: 2162 TVRNK 2166
Score = 35.0 bits (79), Expect = 0.34
Identities = 33/114 (28%), Positives = 54/114 (47%), Gaps = 7/114 (6%)
Query: 150 VHIQVNDVNEYAPVFKEKSYKATVIEG-KQYDSILRVEAVDADCSPQFSQICSYEIITPD 208
V I + D N +AP+F SY T+ E S+L V A D D + +Y I P
Sbjct: 444 VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGE--NGYVTYSIAGPK 501
Query: 209 -VPFTVDKD-GYIKNTEKLNYG-KEHQYKLTVTAYDCGKK-RATEDVLVKISIK 258
+PF++D G I ++ ++Y + Y V A D G R ++V + + ++
Sbjct: 502 ALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLR 555
Score = 35.0 bits (79), Expect = 0.34
Identities = 54/236 (22%), Positives = 93/236 (39%), Gaps = 25/236 (10%)
Query: 29 ARVNKHKPWLEPTYHGIVTENDNTVLLDPPLI-ALDKDAPLRFAESFEVTVTKEGEICGF 87
A +N H+P T + + D ++ + A+D+D +G+ +
Sbjct: 1439 ANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQD---------------KGKSLIY 1483
Query: 88 KIHGQNVPFDAVVVDKSTGEGVIRSKEKLDC-ELQKDYSFTIQAYDCGKGPDGTNVKKSH 146
IHG P A + GV+ + KLD ++ T+ D +K++
Sbjct: 1484 TIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRD-----QEIPIKRNF 1538
Query: 147 KATVHIQVNDVNEYAPVFKEKSYKATVIEG-KQYDSILRVEAVDADCSPQFSQICSYEII 205
V I V D N + P F + Y+A+V + +L+V A+DAD S
Sbjct: 1539 -VWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKG 1597
Query: 206 TPDVPFTVDK-DGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPT 260
+ F ++ G I +KL+ + LTV A D G + + V I + P+
Sbjct: 1598 NSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPS 1653
Score = 33.9 bits (76), Expect = 0.77
Identities = 29/108 (26%), Positives = 53/108 (49%), Gaps = 9/108 (8%)
Query: 147 KATVHIQVN--DVNEYAPVFKEKSYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYE 203
+ATV + +N + N+Y+P F++ Y+A + E + ++ + A+D D P + Y
Sbjct: 2462 RATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGT--IDYT 2519
Query: 204 IIT--PDVPFTVDKDGYIKNTEKLN--YGKEHQYKLTVTAYDCGKKRA 247
II F+++ +G I +KL+ E + V A D G + A
Sbjct: 2520 IINKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMARDGGGRVA 2567
Score = 33.1 bits (74), Expect = 1.3
Identities = 34/132 (25%), Positives = 54/132 (40%), Gaps = 11/132 (8%)
Query: 116 LDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIE 175
L+ E++ Y+ IQA + ++ V + + D N+ P+F SY+ T+ E
Sbjct: 107 LNREVRDSYTLIIQATE-------KTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISE 159
Query: 176 GKQYDS-ILRVEAVDADCSPQFSQICSYEIITPDVPFTV-DKDGYIKNTEKLNYGKEHQY 233
S I +V A DAD Y T F + G + KLN ++
Sbjct: 160 DMPLKSPICKVTATDADLGQNAE--FYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKH 217
Query: 234 KLTVTAYDCGKK 245
+L V A D +K
Sbjct: 218 ELQVLAVDRMRK 229
Score = 33.1 bits (74), Expect = 1.3
Identities = 38/147 (25%), Positives = 56/147 (38%), Gaps = 25/147 (17%)
Query: 31 VNKHKPWLEPTYHGIVTENDNTVLLDPPLI--ALDKDAPLRFAESFEVTVTKEGEICGFK 88
VN + P P+ H V DNT + P + A D D + + + EG
Sbjct: 3106 VNDNAPRFFPS-HCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFS--- 3161
Query: 89 IHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKA 148
+D +TG VIR ++ L Q T++A D GT + S
Sbjct: 3162 ------------IDATTG--VIRLEKPLQVRPQAPLELTVRASDL-----GTPIPLSTLG 3202
Query: 149 TVHIQVNDVNEYAPVFKEKSYKATVIE 175
TV + V + +Y PVF + V E
Sbjct: 3203 TVTVSVVGLEDYLPVFLNTEHSVQVPE 3229
Score = 32.7 bits (73), Expect = 1.7
Identities = 44/154 (28%), Positives = 72/154 (46%), Gaps = 19/154 (12%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G+I +KLD ++ T++A D G P ++ ATV I V + AP+F +
Sbjct: 1610 GIITLAQKLDQANHAPHTLTVKAEDQGS-PQWHDL-----ATVIIHVYPSDRSAPIFSKS 1663
Query: 168 SYKATVIEGKQYDS-ILRVEAVDADCSPQFSQICSYEII--TPDVPFTVDK-DGYIKNTE 223
Y + E S IL V A+ SP S++ +YE+ D F+++ G I +
Sbjct: 1664 EYFVEIPESIPVGSPILLVSAM----SP--SEV-TYELREGNKDGVFSMNSYSGLISTQK 1716
Query: 224 KLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
KL++ K Y+L + + A DV+V + I
Sbjct: 1717 KLDHEKISSYQLKIRGSNMA--GAFTDVMVVVDI 1748
Score = 31.2 bits (69), Expect = 5.0
Identities = 28/99 (28%), Positives = 43/99 (43%), Gaps = 9/99 (9%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
+D S G I S+ +D E + F + +D G + A V I V DVN+
Sbjct: 1815 IDPSMGTLTIVSE--MDYESMPSFQFCVYVHDQGSPV----LFAPRPAQVIIHVRDVNDS 1868
Query: 161 APVFKEKSYKATVIEGKQYD--SILRVEAVDADCSPQFS 197
P F E+ Y+ ++ G + +L V A D D +S
Sbjct: 1869 PPRFSEQIYEVAIV-GPIHPGMELLMVRASDEDSEVNYS 1906
Score = 30.4 bits (67), Expect = 8.5
Identities = 36/157 (22%), Positives = 64/157 (40%), Gaps = 16/157 (10%)
Query: 141 NVKKSHKATVHIQVNDVNEYAPVFKEKSYKAT-VIEGKQYDSIL-RVEAVDADCSPQFSQ 198
N + S + + +N Y P F++ ++ V+E ++ L R+ A D D F+
Sbjct: 691 NQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAG--FNG 748
Query: 199 ICSYEIITPDVPFTVD---KDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKI 255
Y I + D + G + L+Y + Y L VT YD G + + L+ +
Sbjct: 749 KLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTV 808
Query: 256 SIKPTCTPGWQGWN-NRIEYEPGTGALAVFPNIHLET 291
++K WN N + PG L + + + T
Sbjct: 809 NVK--------DWNDNAPRFPPGGYQLTISEDTEVGT 837
>gi|14270508 protocadherin gamma subfamily B, 7 isoform 2 precursor
[Homo sapiens]
Length = 808
Score = 54.3 bits (129), Expect = 5e-07
Identities = 58/225 (25%), Positives = 96/225 (42%), Gaps = 32/225 (14%)
Query: 45 IVTENDNTVLLDPP---LIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVV 101
I+T + ++ D P ++AL K E+ EV + + FKIH + + +V
Sbjct: 348 IITSLSDQIMEDSPPGVVVALFKTRDQDSGENGEVRCSLSRGV-PFKIHSSSNNYYKLVT 406
Query: 102 DKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYA 161
D E LD E +Y+ TI A D GK P S T+ + + DVN+ A
Sbjct: 407 D-----------EALDREQTPEYNVTIAATDRGKPP------LSSSKTITLHITDVNDNA 449
Query: 162 PVFKEKSYKATVIEGKQYD-SILRVEAVDADCSPQFSQICSYEIITPDVPFTV------- 213
PVF + +Y V E Q SI +V A D D + SY +I D+
Sbjct: 450 PVFGQSAYLVHVPENNQPGASIAQVSASDPDFG--LNGRVSYSLIASDLESRTLSSYVSV 507
Query: 214 -DKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
+ G + ++ + ++LT+ A D G + +V +++ +
Sbjct: 508 SAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLV 552
Score = 42.0 bits (97), Expect = 0.003
Identities = 38/147 (25%), Positives = 62/147 (42%), Gaps = 10/147 (6%)
Query: 113 KEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKAT 172
++ LD E Q + + A D G P +S A + I V D N+ PVF + Y+ +
Sbjct: 197 QKTLDRETQSAHHLVLTALDGGDPP------RSGTAQIRILVIDANDNPPVFSQDVYRVS 250
Query: 173 VIEG-KQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKD---GYIKNTEKLNYG 228
+ E SILRV+A D D S+ + D G I + L++
Sbjct: 251 LREDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFE 310
Query: 229 KEHQYKLTVTAYDCGKKRATEDVLVKI 255
+ +Y + + A D G V+V++
Sbjct: 311 EVERYTINIEAKDRGSLSTRCKVIVEV 337
>gi|11128027 protocadherin gamma subfamily B, 7 isoform 1 precursor
[Homo sapiens]
Length = 929
Score = 54.3 bits (129), Expect = 5e-07
Identities = 58/225 (25%), Positives = 96/225 (42%), Gaps = 32/225 (14%)
Query: 45 IVTENDNTVLLDPP---LIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVV 101
I+T + ++ D P ++AL K E+ EV + + FKIH + + +V
Sbjct: 348 IITSLSDQIMEDSPPGVVVALFKTRDQDSGENGEVRCSLSRGV-PFKIHSSSNNYYKLVT 406
Query: 102 DKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYA 161
D E LD E +Y+ TI A D GK P S T+ + + DVN+ A
Sbjct: 407 D-----------EALDREQTPEYNVTIAATDRGKPP------LSSSKTITLHITDVNDNA 449
Query: 162 PVFKEKSYKATVIEGKQYD-SILRVEAVDADCSPQFSQICSYEIITPDVPFTV------- 213
PVF + +Y V E Q SI +V A D D + SY +I D+
Sbjct: 450 PVFGQSAYLVHVPENNQPGASIAQVSASDPDFG--LNGRVSYSLIASDLESRTLSSYVSV 507
Query: 214 -DKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
+ G + ++ + ++LT+ A D G + +V +++ +
Sbjct: 508 SAQSGVVFAQRAFDHEQLRTFELTLQARDQGSPALSANVSLRVLV 552
Score = 42.0 bits (97), Expect = 0.003
Identities = 38/147 (25%), Positives = 62/147 (42%), Gaps = 10/147 (6%)
Query: 113 KEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKAT 172
++ LD E Q + + A D G P +S A + I V D N+ PVF + Y+ +
Sbjct: 197 QKTLDRETQSAHHLVLTALDGGDPP------RSGTAQIRILVIDANDNPPVFSQDVYRVS 250
Query: 173 VIEG-KQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKD---GYIKNTEKLNYG 228
+ E SILRV+A D D S+ + D G I + L++
Sbjct: 251 LREDVPPGTSILRVKATDQDEGINSEITYSFFGVADKAQHVFSLDYTTGNILTQQPLDFE 310
Query: 229 KEHQYKLTVTAYDCGKKRATEDVLVKI 255
+ +Y + + A D G V+V++
Sbjct: 311 EVERYTINIEAKDRGSLSTRCKVIVEV 337
>gi|11128029 protocadherin gamma subfamily B, 6 isoform 1 precursor
[Homo sapiens]
Length = 930
Score = 53.5 bits (127), Expect = 9e-07
Identities = 60/225 (26%), Positives = 98/225 (43%), Gaps = 32/225 (14%)
Query: 45 IVTENDNTVLLDPP---LIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVV 101
I+T + +L + P ++AL K L F + EV E +I FKI+ + + +V
Sbjct: 348 IITSLSDQILENSPPGMVVALFKTRDLDFGGNGEVRCNIETDI-PFKIYSSSNNYYKLVT 406
Query: 102 DKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYA 161
D + LD E +Y+ TI A D GK P S ++ + V D+N+ A
Sbjct: 407 DGA-----------LDREQTPEYNVTIVATDRGKPP------LSSSRSITLYVADINDNA 449
Query: 162 PVFKEKSYKATVIEGKQYD-SILRVEAVDADCSPQFSQICSYEIITPDV-PFTVD----- 214
PVF + SY V E SI +V A D D + SY I+ D+ P V
Sbjct: 450 PVFDQTSYVVHVAENNPPGASIAQVSASDPDLG--LNGHISYSIVASDLEPLAVSSYVSV 507
Query: 215 --KDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
+ G + ++ + + LT+ A D G + +V +++ +
Sbjct: 508 SAQSGVVFAQRAFDHEQLRAFALTLQARDHGSPTLSANVSLRVLV 552
Score = 47.8 bits (112), Expect = 5e-05
Identities = 46/162 (28%), Positives = 73/162 (45%), Gaps = 11/162 (6%)
Query: 99 VVVDKSTGEGVIRSKEKL-DCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDV 157
V V+ G+ S EKL D E Q+ +S + A D G P +S A + I V D
Sbjct: 182 VRVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPP------RSATAHIEISVKDT 235
Query: 158 NEYAPVFKEKSYKATVIEGKQYDS-ILRVEAVDAD--CSPQFSQICSYEIITPDVPFTVD 214
N+ PVF Y+ ++ E S +L+V A D D + + + + F++D
Sbjct: 236 NDNPPVFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLD 295
Query: 215 -KDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKI 255
K G IKN + ++ +Y + V A D G V+++I
Sbjct: 296 EKTGMIKNNQSFDFEDVERYTMEVEAKDGGGLSTQCKVIIEI 337
Score = 32.0 bits (71), Expect = 2.9
Identities = 29/119 (24%), Positives = 55/119 (46%), Gaps = 10/119 (8%)
Query: 150 VHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVE-AVDADCSPQFSQICSYEIITP- 207
V + + DVN++AP F +K + E + L ++ A D D + + I Y+I +
Sbjct: 119 VIVVIEDVNDHAPQFDKKEIHLEIFESASAGTRLSLDPATDPDIN--INSIKDYKINSNP 176
Query: 208 --DVPFTVDKDG----YIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPT 260
+ V+ DG + + L+ ++ + L +TA D G + ++IS+K T
Sbjct: 177 YFSLMVRVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDT 235
>gi|14270502 protocadherin gamma subfamily B, 6 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 53.5 bits (127), Expect = 9e-07
Identities = 60/225 (26%), Positives = 98/225 (43%), Gaps = 32/225 (14%)
Query: 45 IVTENDNTVLLDPP---LIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVV 101
I+T + +L + P ++AL K L F + EV E +I FKI+ + + +V
Sbjct: 348 IITSLSDQILENSPPGMVVALFKTRDLDFGGNGEVRCNIETDI-PFKIYSSSNNYYKLVT 406
Query: 102 DKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYA 161
D + LD E +Y+ TI A D GK P S ++ + V D+N+ A
Sbjct: 407 DGA-----------LDREQTPEYNVTIVATDRGKPP------LSSSRSITLYVADINDNA 449
Query: 162 PVFKEKSYKATVIEGKQYD-SILRVEAVDADCSPQFSQICSYEIITPDV-PFTVD----- 214
PVF + SY V E SI +V A D D + SY I+ D+ P V
Sbjct: 450 PVFDQTSYVVHVAENNPPGASIAQVSASDPDLG--LNGHISYSIVASDLEPLAVSSYVSV 507
Query: 215 --KDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
+ G + ++ + + LT+ A D G + +V +++ +
Sbjct: 508 SAQSGVVFAQRAFDHEQLRAFALTLQARDHGSPTLSANVSLRVLV 552
Score = 47.8 bits (112), Expect = 5e-05
Identities = 46/162 (28%), Positives = 73/162 (45%), Gaps = 11/162 (6%)
Query: 99 VVVDKSTGEGVIRSKEKL-DCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDV 157
V V+ G+ S EKL D E Q+ +S + A D G P +S A + I V D
Sbjct: 182 VRVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPP------RSATAHIEISVKDT 235
Query: 158 NEYAPVFKEKSYKATVIEGKQYDS-ILRVEAVDAD--CSPQFSQICSYEIITPDVPFTVD 214
N+ PVF Y+ ++ E S +L+V A D D + + + + F++D
Sbjct: 236 NDNPPVFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLD 295
Query: 215 -KDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKI 255
K G IKN + ++ +Y + V A D G V+++I
Sbjct: 296 EKTGMIKNNQSFDFEDVERYTMEVEAKDGGGLSTQCKVIIEI 337
Score = 32.0 bits (71), Expect = 2.9
Identities = 29/119 (24%), Positives = 55/119 (46%), Gaps = 10/119 (8%)
Query: 150 VHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVE-AVDADCSPQFSQICSYEIITP- 207
V + + DVN++AP F +K + E + L ++ A D D + + I Y+I +
Sbjct: 119 VIVVIEDVNDHAPQFDKKEIHLEIFESASAGTRLSLDPATDPDIN--INSIKDYKINSNP 176
Query: 208 --DVPFTVDKDG----YIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPT 260
+ V+ DG + + L+ ++ + L +TA D G + ++IS+K T
Sbjct: 177 YFSLMVRVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDT 235
>gi|11036654 protocadherin beta 13 precursor [Homo sapiens]
Length = 798
Score = 53.5 bits (127), Expect = 9e-07
Identities = 55/211 (26%), Positives = 87/211 (41%), Gaps = 22/211 (10%)
Query: 42 YHGIVTENDNTVLLDPPL--IALDKDAPLRF----AESFEVTVTKEGEICGFKIHGQNVP 95
Y ++ NDN + P + + +D+P+ F + +V GEI
Sbjct: 230 YIEVLDVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEEI 289
Query: 96 FDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVN 155
++ TGE I K++LD E + Y I+A D G S K TV IQV
Sbjct: 290 GKTFKINPLTGE--IELKKQLDFEKLQSYEVNIEARDAGTF--------SGKCTVLIQVI 339
Query: 156 DVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVD- 214
DVN++AP ++ + + E + D D CS I D+PF +
Sbjct: 340 DVNDHAPEVTMSAFTSPIPENAPETVVALFSVSDLDSGENGKISCS---IQEDLPFLLKS 396
Query: 215 -KDGYIKNTEK-LNYGKEHQYKLTVTAYDCG 243
++ Y TE+ L+ +Y +T+T D G
Sbjct: 397 AENFYTLLTERPLDRESRAEYNITITVTDLG 427
Score = 43.9 bits (102), Expect = 7e-04
Identities = 37/144 (25%), Positives = 66/144 (45%), Gaps = 10/144 (6%)
Query: 116 LDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIE 175
LD E + + T+ A D G P +S A V+I+V DVN+ AP F++ Y+ + E
Sbjct: 201 LDREEEAELRLTLTALDGGSPP------RSGTAQVYIEVLDVNDNAPEFEQPFYRVQISE 254
Query: 176 GKQYD-SILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKD---GYIKNTEKLNYGKEH 231
+++V A D D S + ++ T + G I+ ++L++ K
Sbjct: 255 DSPVGFLVVKVSATDVDTGVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQ 314
Query: 232 QYKLTVTAYDCGKKRATEDVLVKI 255
Y++ + A D G VL+++
Sbjct: 315 SYEVNIEARDAGTFSGKCTVLIQV 338
Score = 38.5 bits (88), Expect = 0.031
Identities = 39/155 (25%), Positives = 69/155 (44%), Gaps = 17/155 (10%)
Query: 112 SKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKA 171
++ LD E + +Y+ TI D G T + + + + DVN+ AP F + SY
Sbjct: 405 TERPLDRESRAEYNITITVTDLGTPMLITQLNMT------VLIADVNDNAPAFTQTSYTL 458
Query: 172 TVIEGKQYDSILR-VEAVDADCSPQFSQICSYEIITPDVP-------FTVDKD-GYIKNT 222
V E +R V A D D S +Q+ +Y ++ P P +++ D G++
Sbjct: 459 FVRENNSPALHIRSVSATDRD-SGTNAQV-TYSLLPPQDPHLPLTSLVSINADNGHLFAL 516
Query: 223 EKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
L+Y ++ V A D G + + LV++ +
Sbjct: 517 RSLDYEALQGFQFRVGASDHGSPALSSEALVRVVV 551
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 53.1 bits (126), Expect = 1e-06
Identities = 55/218 (25%), Positives = 95/218 (43%), Gaps = 17/218 (7%)
Query: 45 IVTENDNTVLLDPPL--IALDKDAPLRFAE-SFEVTVTKEGEICGFKIHGQNVPFDAVVV 101
++ NDN + P + L++DA + + + + + +++ G N + +
Sbjct: 677 VLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTR-NRFAL 735
Query: 102 DKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYA 161
G G+I LD + ++ Y + A DGT +SH A V I V D N +
Sbjct: 736 SSQRGGGLITLALPLDYKQEQQYVLAVTA------SDGT---RSHTAHVLINVTDANTHR 786
Query: 162 PVFKEKSYKATVIEGKQY-DSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKD-GYI 219
PVF+ Y +V E + SI + A D D + +Y I P F +D D G +
Sbjct: 787 PVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGE--NARITYVIQDPVPQFRIDPDSGTM 844
Query: 220 KNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
+L+Y + Y LT+ A D G + ++ ++I I
Sbjct: 845 YTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILI 882
Score = 52.8 bits (125), Expect = 2e-06
Identities = 41/149 (27%), Positives = 70/149 (46%), Gaps = 10/149 (6%)
Query: 100 VVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNE 159
V + GV+ ++ LD E +Y ++A D G+ P S ATV+I+V D N+
Sbjct: 399 VFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPL----SATATVYIEVEDEND 454
Query: 160 YAPVFKEKSYKATVIEGKQYD-SILRVEAVDADCSPQFSQICSYEIITPDVP---FTVDK 215
P F E++Y V E + ++LRV+A D D + Y I++ +V +
Sbjct: 455 NYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQ--NAAIHYSILSGNVAGQFYLHSL 512
Query: 216 DGYIKNTEKLNYGKEHQYKLTVTAYDCGK 244
G + L++ +Y L++ A D G+
Sbjct: 513 SGILDVINPLDFEDVQKYSLSIKAQDGGR 541
Score = 52.8 bits (125), Expect = 2e-06
Identities = 48/158 (30%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 115 KLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVI 174
+LD E + YSF ++A D G P S +V I V DVN+ PVF + +Y+ +
Sbjct: 644 ELDREEVEHYSFGVEAVDHGSPP------MSSSTSVSITVLDVNDNDPVFTQPTYELRLN 697
Query: 175 EGKQY-DSILRVEAVDADCSPQFSQICSYEIITPDV--PFTVDKD---GYIKNTEKLNYG 228
E S+L ++A D D + + +Y++ + F + G I L+Y
Sbjct: 698 EDAAVGSSVLTLQARDRDA----NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK 753
Query: 229 KEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQ 266
+E QY L VTA D G + T VL+ ++ T P +Q
Sbjct: 754 QEQQYVLAVTASD-GTRSHTAHVLINVTDANTHRPVFQ 790
Score = 51.2 bits (121), Expect = 5e-06
Identities = 44/171 (25%), Positives = 73/171 (42%), Gaps = 28/171 (16%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
G++ LD E + YS +I+A D G+ P + V +QV DVN+ P+F
Sbjct: 514 GILDVINPLDFEDVQKYSLSIKAQDGGRPP-----LINSSGVVSVQVLDVNDNEPIFVSS 568
Query: 168 SYKATVIEGKQYD-SILRVEAVDADCSPQFSQICSYEII-------------------TP 207
++ATV+E ++ ++AVDAD + Y ++ TP
Sbjct: 569 PFQATVLENVPLGYPVVHIQAVDADSGE--NARLHYRLVDTASTFLGGGSAGPKNPAPTP 626
Query: 208 DVPFTV-DKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
D PF + + G+I +L+ + Y V A D G + V I++
Sbjct: 627 DFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITV 677
Score = 44.7 bits (104), Expect = 4e-04
Identities = 53/216 (24%), Positives = 87/216 (40%), Gaps = 28/216 (12%)
Query: 32 NKHKPWLEPTYHGIVTENDNTVLLD-PPLIALDKDAPLRFAESFEVTVTKEGEICGFKIH 90
N H+P + +++ + D V L A D+D E+ +T + + F+I
Sbjct: 783 NTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDT----GENARITYVIQDPVPQFRID 838
Query: 91 GQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATV 150
+ G + + +LD E Q Y+ TI A D G +KS T+
Sbjct: 839 PDS--------------GTMYTMMELDYENQVAYTLTIMAQDNGIP------QKSDTTTL 878
Query: 151 HIQVNDVNEYAPVFKEKSYKATVIE-GKQYDSILRVEAVDADCSPQFSQICSYE-IITPD 208
I + D N+ AP F Y+ ++ E SIL+V A D D P + +++ D
Sbjct: 879 EILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGD 938
Query: 209 VPFTVD-KDGYIKNTEKLNYGKEHQYKLTVTAYDCG 243
F ++ G I+ +L+ Y L A D G
Sbjct: 939 GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRG 974
Score = 40.8 bits (94), Expect = 0.006
Identities = 39/162 (24%), Positives = 74/162 (45%), Gaps = 17/162 (10%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
+D +TG + + LD E ++ + ++A D P +S + + V D N++
Sbjct: 298 IDSATG--AVSTDSVLDRETKETHVLRVKAVDYSTPP------RSATTYITVLVKDTNDH 349
Query: 161 APVFKEKSYKATVIEGKQYD-SILRVEAVDADCSPQFSQICSYEII--TPDVPFTVDKDG 217
+PVF++ Y+ V E + +L + A D D SP + + Y ++ DV + G
Sbjct: 350 SPVFEQSEYRERVRENLEVGYEVLTIRASDRD-SPINANL-RYRVLGGAWDVFQLNESSG 407
Query: 218 YIKNTEKLNYGKEHQYKLTVTAYDCGKK----RATEDVLVKI 255
+ L+ + +Y+L V A D G+ AT V +++
Sbjct: 408 VVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEV 449
Score = 40.8 bits (94), Expect = 0.006
Identities = 45/165 (27%), Positives = 78/165 (47%), Gaps = 13/165 (7%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEK 167
GVIR++ +LD E Y+ A D G+ S + + + D+N+ AP+F++
Sbjct: 948 GVIRTQRRLDRENVAVYNLWALAVD-----RGSPTPLSASVEIQVTILDINDNAPMFEKD 1002
Query: 168 SYKATVIEGKQYDSIL-RVEAVDADCSPQFSQICSYEIITPDVP--FTVD-KDGYIKNTE 223
+ V E S++ ++ A D D P +QI Y+I+ D+ F +D +G ++
Sbjct: 1003 ELELFVEENNPVGSVVAKIRANDPDEGPN-AQI-MYQIVEGDMRHFFQLDLLNGDLRAMV 1060
Query: 224 KLNYGKEHQYKLTVTAYDCG-KKRATEDV-LVKISIKPTCTPGWQ 266
+L++ +Y L V A RAT + LV + P P +Q
Sbjct: 1061 ELDFEVRREYVLVVQATSAPLVSRATVHILLVDQNDNPPVLPDFQ 1105
>gi|17975763 myelin transcription factor 1 [Homo sapiens]
Length = 1121
Score = 53.1 bits (126), Expect = 1e-06
Identities = 27/62 (43%), Positives = 36/62 (58%)
Query: 919 EDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQGDPQNATRQQQLEWDDST 978
ED+ EEEEEEEE+EE E+ EEE++ E E EEEE E+ + + A + D S
Sbjct: 260 EDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSH 319
Query: 979 LS 980
S
Sbjct: 320 TS 321
Score = 52.4 bits (124), Expect = 2e-06
Identities = 67/274 (24%), Positives = 107/274 (39%), Gaps = 57/274 (20%)
Query: 695 EGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMARLQQKGIEVSSSE 754
+ DG+ED V+++ VS+E L+ E G++ H E+ E R K S+
Sbjct: 90 DSDGSEDTEVKDASVSDESEGTLEGAEAETSGQDEIHRPETAE---GRSPVKSHFGSNPI 146
Query: 755 LGMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKLICSELNGRYISNEFKVEVNVIH 814
T + + +SY+ ++ A SLL N I+ E VE ++
Sbjct: 147 GSATASSKGSYSSYQGII---------ATSLL-----------NLGQIAEETLVEEDLGQ 186
Query: 815 TANPMEHANHMAAQPQFVHPEHRSFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFM 874
A P P VH + + + P A V+ V
Sbjct: 187 AAKP---------GPGIVHLLQEAAEGAASEE--GEKGLFIQPEDAEEVVEVT------- 228
Query: 875 IILGVFRIRAAHRRTMRDQDTGKENEMDW--DDSALTITVNPMETYEDQHSSEEEEEEEE 932
T R QD ++ D ++S+ + E +++ EEEEEEE+
Sbjct: 229 --------------TERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEED 274
Query: 933 EEESEDGEEEDDITSAESESSEEEEGEQGDPQNA 966
EEE E+ EEE++ E E EEEE E+ + + A
Sbjct: 275 EEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAA 308
Score = 51.6 bits (122), Expect = 4e-06
Identities = 24/48 (50%), Positives = 31/48 (64%)
Query: 916 ETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQGDP 963
E E++ EEE+EEEEEEE E+ EEE++ E E EEEE E+ P
Sbjct: 262 EEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAP 309
Score = 50.8 bits (120), Expect = 6e-06
Identities = 22/50 (44%), Positives = 32/50 (64%)
Query: 922 HSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQGDPQNATRQQQ 971
H E+EEEEEEEEE E+ EEE++ E E EEEE E+ + + +++
Sbjct: 257 HEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE 306
Score = 50.4 bits (119), Expect = 8e-06
Identities = 23/62 (37%), Positives = 37/62 (59%)
Query: 917 TYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQGDPQNATRQQQLEWDD 976
++E++ EEEEEEEEEE+ E+ EEE++ E E EEEE E+ + + + + +
Sbjct: 256 SHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQE 315
Query: 977 ST 978
T
Sbjct: 316 DT 317
Score = 37.7 bits (86), Expect = 0.053
Identities = 19/65 (29%), Positives = 36/65 (55%), Gaps = 4/65 (6%)
Query: 916 ETYEDQHSSEEEEEE----EEEEESEDGEEEDDITSAESESSEEEEGEQGDPQNATRQQQ 971
++ ED S E +++ EEE+ E+ EEE++ E E EEEE E+ + + +++
Sbjct: 238 QSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEE 297
Query: 972 LEWDD 976
E ++
Sbjct: 298 EEEEE 302
>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
Length = 794
Score = 52.8 bits (125), Expect = 2e-06
Identities = 50/171 (29%), Positives = 74/171 (43%), Gaps = 22/171 (12%)
Query: 99 VVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHK----------A 148
+V D+ T EGVI+ K+ LD E +K Y+F ++A +N+ H+ A
Sbjct: 319 IVTDEDTQEGVIKLKKPLDFETKKAYTFKVEA---------SNLHLDHRFHSAGPFKDTA 369
Query: 149 TVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSIL-RVEAVDADCSPQFSQICSYEIITP 207
TV I V DV+E PVF + Y V E +I+ V A D D +
Sbjct: 370 TVKISVLDVDE-PPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDG 428
Query: 208 DVPFTVD-KDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISI 257
D FT+D +G I E L+ QY ++ A T V + I++
Sbjct: 429 DSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINV 479
Score = 43.9 bits (102), Expect = 7e-04
Identities = 43/148 (29%), Positives = 69/148 (46%), Gaps = 13/148 (8%)
Query: 101 VDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEY 160
+D++TG+ I + LD E + Y+ QA D T ++ I+V D+N+
Sbjct: 104 IDETTGD--IHAIRSLDREEKPFYTLRAQAVDIE-----TRKPLEPESEFIIKVQDINDN 156
Query: 161 APVFKEKSYKATVIEGKQYDS-ILRVEAVDADCSPQF--SQICSYEIITPDVPFTVDKDG 217
P F + Y ATV E + +L+V+A DAD P + S Y I+ F++D
Sbjct: 157 EPKFLDGPYVATVPEMSPVGAYVLQVKATDAD-DPTYGNSARVVYSILQGQPYFSIDPKT 215
Query: 218 YIKNTEKLNYGKE--HQYKLTVTAYDCG 243
+ T N +E QY++ + A D G
Sbjct: 216 GVIRTALPNMDREVKEQYQVLIQAKDMG 243
Score = 37.7 bits (86), Expect = 0.053
Identities = 33/95 (34%), Positives = 44/95 (46%), Gaps = 11/95 (11%)
Query: 107 EGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKE 166
EG I + E LD E Y+F+I A +N + K + I V DVNE+ P
Sbjct: 438 EGTIATNELLDRESTAQYNFSIIASKV------SNPLLTSKVNILINVLDVNEFPPEI-S 490
Query: 167 KSYKATVIEGKQYDSILR-VEAVDADCSP---QFS 197
Y+ V E + I++ V A D D SP QFS
Sbjct: 491 VPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFS 525
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
Length = 1955
Score = 52.4 bits (124), Expect = 2e-06
Identities = 38/117 (32%), Positives = 57/117 (48%), Gaps = 6/117 (5%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNV-KKSHKATVHIQVNDVNEYAPVFKE 166
GVI LD E + Y +QA V KS+ A V+I++ D N + PVF++
Sbjct: 1087 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Query: 167 KSYKATVIE-GKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNT 222
K Y V E + + S+LRV+A D D + +Y +I P P K+G++ T
Sbjct: 1147 KFYIGGVSEDARMFTSVLRVKATDKDTGNY--SVMAYRLIIP--PIKEGKEGFVVET 1199
Score = 50.1 bits (118), Expect = 1e-05
Identities = 52/174 (29%), Positives = 79/174 (45%), Gaps = 39/174 (22%)
Query: 32 NKHKPWLE-PTYHGIVTEN--------DNTVLLDP-PLIALDKDAPLRFAESFEVTVTKE 81
N P+ P+Y G + E+ D+ L P ++ALDKD + TK+
Sbjct: 389 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD----------IEDTKD 438
Query: 82 GEICGFKIHGQNVPFDAVVVDKSTGEGVIRSK---EKLDCELQKDYSFTIQAYDCGKGPD 138
E+ F D V T G+ R + +D E Q+ Y+F+I A+D
Sbjct: 439 PELHLFLN-------DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD------ 485
Query: 139 GTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATV-IEGKQYDSILRVEAVDAD 191
V++S V+IQV D N+ P F E SY V + + DS++++ AVDAD
Sbjct: 486 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Score = 45.4 bits (106), Expect = 3e-04
Identities = 42/141 (29%), Positives = 63/141 (44%), Gaps = 15/141 (10%)
Query: 125 SFTIQAYDC-GKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVI-EGKQYDSI 182
+F ++A+D G P G ATV + V D+N+Y PVF ++ YK V + + I
Sbjct: 893 TFLVEAFDIYGTMPPGI-------ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 183 LRVEAVDADCSPQFSQICSYEIITPDVP-----FTVDKD-GYIKNTEKLNYGKEHQYKLT 236
V A DAD + Y + P F V++D G + LN +KL
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 237 VTAYDCGKKRATEDVLVKISI 257
V A+D G+ + VKI +
Sbjct: 1006 VVAFDDGEPVMSSSATVKILV 1026
Score = 44.7 bits (104), Expect = 4e-04
Identities = 45/143 (31%), Positives = 65/143 (45%), Gaps = 10/143 (6%)
Query: 100 VVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNE 159
V + S G++ + LD E Y I A D G+ PDGT+ ATV+I V DVN+
Sbjct: 660 VFNLSETTGILTLGKALDRESTDRYILIITASD-GR-PDGTST-----ATVNIVVTDVND 712
Query: 160 YAPVFKE-KSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGY 218
APVF +V+E + + +V+A D D + Y + + F + +G
Sbjct: 713 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAG--INGQVHYSLGNFNNLFRITSNGS 770
Query: 219 IKNTEKLNYGKEHQYKLTVTAYD 241
I KLN Y+L V A D
Sbjct: 771 IYTAVKLNREVRDYYELVVVATD 793
Score = 39.3 bits (90), Expect = 0.018
Identities = 45/174 (25%), Positives = 79/174 (45%), Gaps = 19/174 (10%)
Query: 41 TYHGIVTE-NDNTVLLDPPL---IALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPF 96
T + +VT+ NDN + DP L +++ ++ F + T G ++H F
Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAG--INGQVHYSLGNF 759
Query: 97 DAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVND 156
+ + + T G I + KL+ E++ Y + A D P + + T+ I+V D
Sbjct: 760 NNLF--RITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL------TLAIKVLD 811
Query: 157 VNEYAPVFKEKSYKATVIEG-KQYDSILRVEAVDADCSPQFSQICSYEIITPDV 209
+++ +PVF +Y V E +IL++EA D D SY I +P+V
Sbjct: 812 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN----VSYRIRSPEV 861
Score = 35.0 bits (79), Expect = 0.34
Identities = 30/123 (24%), Positives = 54/123 (43%), Gaps = 15/123 (12%)
Query: 148 ATVHIQVNDVNEYAPVFKEKSYK----------ATVIEGKQYDSILRVEAVDADCSPQFS 197
A +HI++ D N +P F SY+ AT+ + S LR+ A+D D
Sbjct: 379 AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438
Query: 198 QICSYEIITPDVPFTVDKDG---YIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVK 254
+ FTV + G Y+ + ++ ++ Y ++TA+D + +E V+V
Sbjct: 439 PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVN 496
Query: 255 ISI 257
I +
Sbjct: 497 IQV 499
Score = 32.3 bits (72), Expect = 2.2
Identities = 32/107 (29%), Positives = 45/107 (42%), Gaps = 18/107 (16%)
Query: 150 VHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRV------EAVDADCSP--QFSQICS 201
V I V D N+ +P FK +SY ATV E + + A D D P Q +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 202 YEIITPDVPFTVDK-------DGYIKNTEKLNYGKEHQYKLTVTAYD 241
Y PD P + D G I ++LNY + +Y + + A D
Sbjct: 193 Y---NPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
Length = 1932
Score = 52.4 bits (124), Expect = 2e-06
Identities = 38/117 (32%), Positives = 57/117 (48%), Gaps = 6/117 (5%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNV-KKSHKATVHIQVNDVNEYAPVFKE 166
GVI LD E + Y +QA V KS+ A V+I++ D N + PVF++
Sbjct: 1065 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1124
Query: 167 KSYKATVIE-GKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNT 222
K Y V E + + S+LRV+A D D + +Y +I P P K+G++ T
Sbjct: 1125 KFYIGGVSEDARMFTSVLRVKATDKDTGNY--SVMAYRLIIP--PIKEGKEGFVVET 1177
Score = 50.1 bits (118), Expect = 1e-05
Identities = 52/174 (29%), Positives = 79/174 (45%), Gaps = 39/174 (22%)
Query: 32 NKHKPWLE-PTYHGIVTEN--------DNTVLLDP-PLIALDKDAPLRFAESFEVTVTKE 81
N P+ P+Y G + E+ D+ L P ++ALDKD + TK+
Sbjct: 367 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD----------IEDTKD 416
Query: 82 GEICGFKIHGQNVPFDAVVVDKSTGEGVIRSK---EKLDCELQKDYSFTIQAYDCGKGPD 138
E+ F D V T G+ R + +D E Q+ Y+F+I A+D
Sbjct: 417 PELHLFLN-------DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD------ 463
Query: 139 GTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATV-IEGKQYDSILRVEAVDAD 191
V++S V+IQV D N+ P F E SY V + + DS++++ AVDAD
Sbjct: 464 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 515
Score = 45.4 bits (106), Expect = 3e-04
Identities = 42/141 (29%), Positives = 63/141 (44%), Gaps = 15/141 (10%)
Query: 125 SFTIQAYDC-GKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVI-EGKQYDSI 182
+F ++A+D G P G ATV + V D+N+Y PVF ++ YK V + + I
Sbjct: 871 TFLVEAFDIYGTMPPGI-------ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 923
Query: 183 LRVEAVDADCSPQFSQICSYEIITPDVP-----FTVDKD-GYIKNTEKLNYGKEHQYKLT 236
V A DAD + Y + P F V++D G + LN +KL
Sbjct: 924 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 983
Query: 237 VTAYDCGKKRATEDVLVKISI 257
V A+D G+ + VKI +
Sbjct: 984 VVAFDDGEPVMSSSATVKILV 1004
Score = 44.7 bits (104), Expect = 4e-04
Identities = 45/143 (31%), Positives = 65/143 (45%), Gaps = 10/143 (6%)
Query: 100 VVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNE 159
V + S G++ + LD E Y I A D G+ PDGT+ ATV+I V DVN+
Sbjct: 638 VFNLSETTGILTLGKALDRESTDRYILIITASD-GR-PDGTST-----ATVNIVVTDVND 690
Query: 160 YAPVFKE-KSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGY 218
APVF +V+E + + +V+A D D + Y + + F + +G
Sbjct: 691 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAG--INGQVHYSLGNFNNLFRITSNGS 748
Query: 219 IKNTEKLNYGKEHQYKLTVTAYD 241
I KLN Y+L V A D
Sbjct: 749 IYTAVKLNREVRDYYELVVVATD 771
Score = 39.3 bits (90), Expect = 0.018
Identities = 45/174 (25%), Positives = 79/174 (45%), Gaps = 19/174 (10%)
Query: 41 TYHGIVTE-NDNTVLLDPPL---IALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPF 96
T + +VT+ NDN + DP L +++ ++ F + T G ++H F
Sbjct: 680 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAG--INGQVHYSLGNF 737
Query: 97 DAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVND 156
+ + + T G I + KL+ E++ Y + A D P + + T+ I+V D
Sbjct: 738 NNLF--RITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL------TLAIKVLD 789
Query: 157 VNEYAPVFKEKSYKATVIEG-KQYDSILRVEAVDADCSPQFSQICSYEIITPDV 209
+++ +PVF +Y V E +IL++EA D D SY I +P+V
Sbjct: 790 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN----VSYRIRSPEV 839
Score = 35.0 bits (79), Expect = 0.34
Identities = 30/123 (24%), Positives = 54/123 (43%), Gaps = 15/123 (12%)
Query: 148 ATVHIQVNDVNEYAPVFKEKSYK----------ATVIEGKQYDSILRVEAVDADCSPQFS 197
A +HI++ D N +P F SY+ AT+ + S LR+ A+D D
Sbjct: 357 AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 416
Query: 198 QICSYEIITPDVPFTVDKDG---YIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVK 254
+ FTV + G Y+ + ++ ++ Y ++TA+D + +E V+V
Sbjct: 417 PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVN 474
Query: 255 ISI 257
I +
Sbjct: 475 IQV 477
Score = 32.3 bits (72), Expect = 2.2
Identities = 32/107 (29%), Positives = 45/107 (42%), Gaps = 18/107 (16%)
Query: 150 VHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRV------EAVDADCSP--QFSQICS 201
V I V D N+ +P FK +SY ATV E + + A D D P Q +
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 202 YEIITPDVPFTVDK-------DGYIKNTEKLNYGKEHQYKLTVTAYD 241
Y PD P + D G I ++LNY + +Y + + A D
Sbjct: 171 Y---NPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 214
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
Length = 1677
Score = 52.4 bits (124), Expect = 2e-06
Identities = 38/117 (32%), Positives = 57/117 (48%), Gaps = 6/117 (5%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNV-KKSHKATVHIQVNDVNEYAPVFKE 166
GVI LD E + Y +QA V KS+ A V+I++ D N + PVF++
Sbjct: 1087 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1146
Query: 167 KSYKATVIE-GKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNT 222
K Y V E + + S+LRV+A D D + +Y +I P P K+G++ T
Sbjct: 1147 KFYIGGVSEDARMFTSVLRVKATDKDTGNY--SVMAYRLIIP--PIKEGKEGFVVET 1199
Score = 50.1 bits (118), Expect = 1e-05
Identities = 52/174 (29%), Positives = 79/174 (45%), Gaps = 39/174 (22%)
Query: 32 NKHKPWLE-PTYHGIVTEN--------DNTVLLDP-PLIALDKDAPLRFAESFEVTVTKE 81
N P+ P+Y G + E+ D+ L P ++ALDKD + TK+
Sbjct: 389 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD----------IEDTKD 438
Query: 82 GEICGFKIHGQNVPFDAVVVDKSTGEGVIRSK---EKLDCELQKDYSFTIQAYDCGKGPD 138
E+ F D V T G+ R + +D E Q+ Y+F+I A+D
Sbjct: 439 PELHLFLN-------DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD------ 485
Query: 139 GTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATV-IEGKQYDSILRVEAVDAD 191
V++S V+IQV D N+ P F E SY V + + DS++++ AVDAD
Sbjct: 486 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
Score = 45.4 bits (106), Expect = 3e-04
Identities = 42/141 (29%), Positives = 63/141 (44%), Gaps = 15/141 (10%)
Query: 125 SFTIQAYDC-GKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVI-EGKQYDSI 182
+F ++A+D G P G ATV + V D+N+Y PVF ++ YK V + + I
Sbjct: 893 TFLVEAFDIYGTMPPGI-------ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
Query: 183 LRVEAVDADCSPQFSQICSYEIITPDVP-----FTVDKD-GYIKNTEKLNYGKEHQYKLT 236
V A DAD + Y + P F V++D G + LN +KL
Sbjct: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
Query: 237 VTAYDCGKKRATEDVLVKISI 257
V A+D G+ + VKI +
Sbjct: 1006 VVAFDDGEPVMSSSATVKILV 1026
Score = 44.7 bits (104), Expect = 4e-04
Identities = 45/143 (31%), Positives = 65/143 (45%), Gaps = 10/143 (6%)
Query: 100 VVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNE 159
V + S G++ + LD E Y I A D G+ PDGT+ ATV+I V DVN+
Sbjct: 660 VFNLSETTGILTLGKALDRESTDRYILIITASD-GR-PDGTST-----ATVNIVVTDVND 712
Query: 160 YAPVFKE-KSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGY 218
APVF +V+E + + +V+A D D + Y + + F + +G
Sbjct: 713 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAG--INGQVHYSLGNFNNLFRITSNGS 770
Query: 219 IKNTEKLNYGKEHQYKLTVTAYD 241
I KLN Y+L V A D
Sbjct: 771 IYTAVKLNREVRDYYELVVVATD 793
Score = 39.3 bits (90), Expect = 0.018
Identities = 45/174 (25%), Positives = 79/174 (45%), Gaps = 19/174 (10%)
Query: 41 TYHGIVTE-NDNTVLLDPPL---IALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPF 96
T + +VT+ NDN + DP L +++ ++ F + T G ++H F
Sbjct: 702 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAG--INGQVHYSLGNF 759
Query: 97 DAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVND 156
+ + + T G I + KL+ E++ Y + A D P + + T+ I+V D
Sbjct: 760 NNLF--RITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL------TLAIKVLD 811
Query: 157 VNEYAPVFKEKSYKATVIEG-KQYDSILRVEAVDADCSPQFSQICSYEIITPDV 209
+++ +PVF +Y V E +IL++EA D D SY I +P+V
Sbjct: 812 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN----VSYRIRSPEV 861
Score = 35.0 bits (79), Expect = 0.34
Identities = 30/123 (24%), Positives = 54/123 (43%), Gaps = 15/123 (12%)
Query: 148 ATVHIQVNDVNEYAPVFKEKSYK----------ATVIEGKQYDSILRVEAVDADCSPQFS 197
A +HI++ D N +P F SY+ AT+ + S LR+ A+D D
Sbjct: 379 AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438
Query: 198 QICSYEIITPDVPFTVDKDG---YIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVK 254
+ FTV + G Y+ + ++ ++ Y ++TA+D + +E V+V
Sbjct: 439 PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVN 496
Query: 255 ISI 257
I +
Sbjct: 497 IQV 499
Score = 32.3 bits (72), Expect = 2.2
Identities = 32/107 (29%), Positives = 45/107 (42%), Gaps = 18/107 (16%)
Query: 150 VHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRV------EAVDADCSP--QFSQICS 201
V I V D N+ +P FK +SY ATV E + + A D D P Q +
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 202 YEIITPDVPFTVDK-------DGYIKNTEKLNYGKEHQYKLTVTAYD 241
Y PD P + D G I ++LNY + +Y + + A D
Sbjct: 193 Y---NPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 236
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
Length = 1682
Score = 52.4 bits (124), Expect = 2e-06
Identities = 38/117 (32%), Positives = 57/117 (48%), Gaps = 6/117 (5%)
Query: 108 GVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNV-KKSHKATVHIQVNDVNEYAPVFKE 166
GVI LD E + Y +QA V KS+ A V+I++ D N + PVF++
Sbjct: 1092 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1151
Query: 167 KSYKATVIE-GKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNT 222
K Y V E + + S+LRV+A D D + +Y +I P P K+G++ T
Sbjct: 1152 KFYIGGVSEDARMFTSVLRVKATDKDTGNY--SVMAYRLIIP--PIKEGKEGFVVET 1204
Score = 50.1 bits (118), Expect = 1e-05
Identities = 52/174 (29%), Positives = 79/174 (45%), Gaps = 39/174 (22%)
Query: 32 NKHKPWLE-PTYHGIVTEN--------DNTVLLDP-PLIALDKDAPLRFAESFEVTVTKE 81
N P+ P+Y G + E+ D+ L P ++ALDKD + TK+
Sbjct: 394 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD----------IEDTKD 443
Query: 82 GEICGFKIHGQNVPFDAVVVDKSTGEGVIRSK---EKLDCELQKDYSFTIQAYDCGKGPD 138
E+ F D V T G+ R + +D E Q+ Y+F+I A+D
Sbjct: 444 PELHLFLN-------DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD------ 490
Query: 139 GTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATV-IEGKQYDSILRVEAVDAD 191
V++S V+IQV D N+ P F E SY V + + DS++++ AVDAD
Sbjct: 491 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 542
Score = 45.4 bits (106), Expect = 3e-04
Identities = 42/141 (29%), Positives = 63/141 (44%), Gaps = 15/141 (10%)
Query: 125 SFTIQAYDC-GKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVI-EGKQYDSI 182
+F ++A+D G P G ATV + V D+N+Y PVF ++ YK V + + I
Sbjct: 898 TFLVEAFDIYGTMPPGI-------ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 950
Query: 183 LRVEAVDADCSPQFSQICSYEIITPDVP-----FTVDKD-GYIKNTEKLNYGKEHQYKLT 236
V A DAD + Y + P F V++D G + LN +KL
Sbjct: 951 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1010
Query: 237 VTAYDCGKKRATEDVLVKISI 257
V A+D G+ + VKI +
Sbjct: 1011 VVAFDDGEPVMSSSATVKILV 1031
Score = 44.7 bits (104), Expect = 4e-04
Identities = 45/143 (31%), Positives = 65/143 (45%), Gaps = 10/143 (6%)
Query: 100 VVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNE 159
V + S G++ + LD E Y I A D G+ PDGT+ ATV+I V DVN+
Sbjct: 665 VFNLSETTGILTLGKALDRESTDRYILIITASD-GR-PDGTST-----ATVNIVVTDVND 717
Query: 160 YAPVFKE-KSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGY 218
APVF +V+E + + +V+A D D + Y + + F + +G
Sbjct: 718 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAG--INGQVHYSLGNFNNLFRITSNGS 775
Query: 219 IKNTEKLNYGKEHQYKLTVTAYD 241
I KLN Y+L V A D
Sbjct: 776 IYTAVKLNREVRDYYELVVVATD 798
Score = 39.3 bits (90), Expect = 0.018
Identities = 45/174 (25%), Positives = 79/174 (45%), Gaps = 19/174 (10%)
Query: 41 TYHGIVTE-NDNTVLLDPPL---IALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPF 96
T + +VT+ NDN + DP L +++ ++ F + T G ++H F
Sbjct: 707 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAG--INGQVHYSLGNF 764
Query: 97 DAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVND 156
+ + + T G I + KL+ E++ Y + A D P + + T+ I+V D
Sbjct: 765 NNLF--RITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL------TLAIKVLD 816
Query: 157 VNEYAPVFKEKSYKATVIEG-KQYDSILRVEAVDADCSPQFSQICSYEIITPDV 209
+++ +PVF +Y V E +IL++EA D D SY I +P+V
Sbjct: 817 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN----VSYRIRSPEV 866
Score = 35.0 bits (79), Expect = 0.34
Identities = 30/123 (24%), Positives = 54/123 (43%), Gaps = 15/123 (12%)
Query: 148 ATVHIQVNDVNEYAPVFKEKSYK----------ATVIEGKQYDSILRVEAVDADCSPQFS 197
A +HI++ D N +P F SY+ AT+ + S LR+ A+D D
Sbjct: 384 AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 443
Query: 198 QICSYEIITPDVPFTVDKDG---YIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVK 254
+ FTV + G Y+ + ++ ++ Y ++TA+D + +E V+V
Sbjct: 444 PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVN 501
Query: 255 ISI 257
I +
Sbjct: 502 IQV 504
Score = 32.3 bits (72), Expect = 2.2
Identities = 32/107 (29%), Positives = 45/107 (42%), Gaps = 18/107 (16%)
Query: 150 VHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRV------EAVDADCSP--QFSQICS 201
V I V D N+ +P FK +SY ATV E + + A D D P Q +
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 202 YEIITPDVPFTVDK-------DGYIKNTEKLNYGKEHQYKLTVTAYD 241
Y PD P + D G I ++LNY + +Y + + A D
Sbjct: 198 Y---NPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND 241
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,631,247
Number of Sequences: 37866
Number of extensions: 2023031
Number of successful extensions: 38953
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 690
Number of HSP's successfully gapped in prelim test: 320
Number of HSP's that attempted gapping in prelim test: 16248
Number of HSP's gapped (non-prelim): 11484
length of query: 981
length of database: 18,247,518
effective HSP length: 112
effective length of query: 869
effective length of database: 14,006,526
effective search space: 12171671094
effective search space used: 12171671094
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.