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Search of human proteins with 56788359
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
(877 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 1890 0.0
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 1843 0.0
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 481 e-136
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 290 5e-78
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 272 9e-73
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 270 4e-72
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 263 5e-70
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 261 2e-69
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 251 3e-66
gi|145309328 papilin [Homo sapiens] 213 8e-55
gi|226442878 ADAMTS-like 5 [Homo sapiens] 209 7e-54
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 202 1e-51
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 196 1e-49
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 191 2e-48
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 190 4e-48
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 178 2e-44
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 176 8e-44
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 169 8e-42
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 169 8e-42
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 167 5e-41
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 153 6e-37
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 153 6e-37
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 153 6e-37
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 152 1e-36
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 152 1e-36
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 149 1e-35
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 144 5e-34
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 141 2e-33
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 134 4e-31
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 130 7e-30
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 1890 bits (4895), Expect = 0.0
Identities = 877/877 (100%), Positives = 877/877 (100%)
Query: 1 MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPC 60
MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPC
Sbjct: 1 MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPC 60
Query: 61 GVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTSPETLPLYRTQSRG 120
GVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTSPETLPLYRTQSRG
Sbjct: 61 GVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTSPETLPLYRTQSRG 120
Query: 121 RGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSPPR 180
RGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSPPR
Sbjct: 121 RGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSPPR 180
Query: 181 SELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEV 240
SELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEV
Sbjct: 181 SELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEV 240
Query: 241 APRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPD 300
APRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPD
Sbjct: 241 APRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPD 300
Query: 301 PFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSP 360
PFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSP
Sbjct: 301 PFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSP 360
Query: 361 IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL 420
IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL
Sbjct: 361 IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL 420
Query: 421 NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD 480
NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD
Sbjct: 421 NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD 480
Query: 481 DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW 540
DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW
Sbjct: 481 DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW 540
Query: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS
Sbjct: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
Query: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP
Sbjct: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
Query: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG
Sbjct: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
Query: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL 780
TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL
Sbjct: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL 780
Query: 781 RLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGP 840
RLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGP
Sbjct: 781 RLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGP 840
Query: 841 CTTAWFHSDWSSKVSPEPPAISCILGNHAQDTSAFPA 877
CTTAWFHSDWSSKVSPEPPAISCILGNHAQDTSAFPA
Sbjct: 841 CTTAWFHSDWSSKVSPEPPAISCILGNHAQDTSAFPA 877
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 1843 bits (4774), Expect = 0.0
Identities = 855/857 (99%), Positives = 855/857 (99%)
Query: 1 MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPC 60
MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPC
Sbjct: 1 MENWTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPC 60
Query: 61 GVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTSPETLPLYRTQSRG 120
GVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTSPETLPLYRTQSRG
Sbjct: 61 GVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTSPETLPLYRTQSRG 120
Query: 121 RGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSPPR 180
RGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSPPR
Sbjct: 121 RGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGYGRVPFALPLHRNRRHPRSPPR 180
Query: 181 SELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEV 240
SELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEV
Sbjct: 181 SELSLISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTPSPQAEPLSPETAQTEV 240
Query: 241 APRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPD 300
APRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPD
Sbjct: 241 APRTRPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRPD 300
Query: 301 PFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSP 360
PFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSP
Sbjct: 301 PFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLWSLFAPSSP 360
Query: 361 IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL 420
IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL
Sbjct: 361 IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL 420
Query: 421 NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD 480
NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD
Sbjct: 421 NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD 480
Query: 481 DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW 540
DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW
Sbjct: 481 DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW 540
Query: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS
Sbjct: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
Query: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP
Sbjct: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
Query: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG
Sbjct: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
Query: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL 780
TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL
Sbjct: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL 780
Query: 781 RLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGP 840
RLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGP
Sbjct: 781 RLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGP 840
Query: 841 CTTAWFHSDWSSKVSPE 857
CTTAWFHSDWSSK S E
Sbjct: 841 CTTAWFHSDWSSKCSAE 857
Score = 109 bits (273), Expect = 1e-23
Identities = 76/246 (30%), Positives = 105/246 (42%), Gaps = 39/246 (15%)
Query: 639 PGTLQRQVRIPQ------MPAPP----HPRTPLGSPAAYWKRVGH-------SACSASCG 681
PGT RQ++ Q PP H P + + + GH S CS CG
Sbjct: 741 PGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCG 800
Query: 682 KGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTS-CSRSCG 740
+G C+ +G+E+ E+ CA+G P S E C PC W +W+S CS CG
Sbjct: 801 RGQRSRQVRCVG-NNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECG 859
Query: 741 PGTQHRQLQCRQEFGGGGSSVPP----------ERCGHLPRPNITQSCQLRLC---GHWE 787
G Q R + C G G+++ P + C RP ++C L C W
Sbjct: 860 TGIQRRSVVCL----GSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRWY 915
Query: 788 VGSPWSQCSVRCGRGQRSRQVRCVGNNGDE--VSEQECASGPPQPPSREACDMGPCTTAW 845
G PW +CS CG G + R + CV G E V+ S P+PP+ + C C W
Sbjct: 916 TG-PWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRW 974
Query: 846 FHSDWS 851
F + WS
Sbjct: 975 FSTPWS 980
Score = 109 bits (272), Expect = 1e-23
Identities = 64/183 (34%), Positives = 83/183 (45%), Gaps = 22/183 (12%)
Query: 674 SACSASCGKGVWRPIFLCISRESGEELDE----------RSCAAGARPPASPEPCHGTPC 723
S CSA CG G+ R +C+ SG L +SC G+RPP C PC
Sbjct: 852 SKCSAECGTGIQRRSVVCLG--SGAALGPGQGEAGAGTGQSCPTGSRPP-DMRACSLGPC 908
Query: 724 PPYWE--AGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLR 781
W G W CS CG GTQ R + C + G + P C HLPRP Q CQ +
Sbjct: 909 ERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQ 968
Query: 782 LCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQ--PPSREACDMG 839
C +PWS CS C G ++R+V+C+ N + C PPQ P + C+
Sbjct: 969 ACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTN--QTLSTRC---PPQLRPSRKRPCNSQ 1023
Query: 840 PCT 842
PC+
Sbjct: 1024 PCS 1026
Score = 69.7 bits (169), Expect = 1e-11
Identities = 40/109 (36%), Positives = 54/109 (49%), Gaps = 5/109 (4%)
Query: 676 CSASCGKGVWRPIFLCISRESGEELDERS---CAAGARPPASPEPCHGTPCPPYWEAGEW 732
CS+ CG G R +C+S+ G E + S C+ RPPA +PC G C W + W
Sbjct: 922 CSSECGSGTQRRDIICVSK-LGTEFNVTSPSNCSHLPRPPAL-QPCQGQACQDRWFSTPW 979
Query: 733 TSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLR 781
+ CSRSC GTQ R++QC + PP+ RP +Q C R
Sbjct: 980 SPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQR 1028
Score = 31.2 bits (69), Expect = 4.4
Identities = 27/80 (33%), Positives = 31/80 (38%), Gaps = 15/80 (18%)
Query: 24 DQEVLSGHSLQTPTEEGQGPEGVWGPWVQ--WAS-CSQPCGVGVQRRSRTCQLPTVQLHP 80
+QE SG Q P+ E W W+S CS CG G+QRRS C L P
Sbjct: 820 EQECASGPP-QPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGP 878
Query: 81 -----------SLPLPPRPP 89
S P RPP
Sbjct: 879 GQGEAGAGTGQSCPTGSRPP 898
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 481 bits (1239), Expect = e-136
Identities = 302/849 (35%), Positives = 406/849 (47%), Gaps = 119/849 (14%)
Query: 40 GQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRG 99
G G GVWG W W++CS+ C GV ++R C P + RG
Sbjct: 49 GGGAPGVWGAWGPWSACSRSCSGGVMEQTRPCL-------------------PRSYRLRG 89
Query: 100 QGPRPQTSPETLPLYRTQSRGRGGPLRGPASHLGREETQEIRAARRSRLRDPIKPGMFGY 159
G RP G P R A H+ + A R S
Sbjct: 90 -GQRP-----------------GAPARAFADHV-------VSAVRTS------------- 111
Query: 160 GRVPFALPLHRNRRHPRSPPRSELSLISSRGEEAIPSPTPRAEPFSANGSPQTE--LPPT 217
+PLHR+R + ++ S P P+ + + +T + P
Sbjct: 112 ------VPLHRSRDETPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPG 165
Query: 218 ELSVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPRAQASGTEP--PSPTHSLGEGGFF 275
+ + +P PL +TA T R + RH AS SP H + + G
Sbjct: 166 KYG-YGKAPYILPLQTDTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHG-- 222
Query: 276 RASPQPRRPSSQGWASPQVAGRRPDPFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHP 335
P S G S A P +P QG H P E H
Sbjct: 223 -----PLYQSDSGPRSGLQAAEAP--IYQLPL---THDQGYPAASSLFHSP--ETSNNH- 269
Query: 336 GAWLPLLSNGPH-ASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQPDPRALQCAAF 394
G H A+ +S A S+ I C G Q + C+ CP R +QCA++
Sbjct: 270 -------GVGTHGATQSFSQPARSTAIS-CIGAYRQYKLCNTNVCPESSRSIREVQCASY 321
Query: 395 NSQEFMGQLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAG 454
N++ FMG+ Y+WEPF EV+G+++CELNC+ G+RFYVR EKV DGT C ICV+G
Sbjct: 322 NNKPFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSG 381
Query: 455 RCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQ 514
+C S GCD LGS + D CGVCGGD++ C++VSG LGY +++ IP GA ++
Sbjct: 382 QCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKIN 441
Query: 515 IAQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPR-EEGKGESLSAE 573
I ++ S+NYLALR GRSIINGNWA+D PG Y GGT+F Y RP GES AE
Sbjct: 442 ITEMYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAE 501
Query: 574 GPTTQPVDVYMIFQEENPGVFYQYVISSPPPILENPTP-----EPPVPQL---------- 618
GPT + +DVYMI Q+ NPGV Y+YVI I P EP Q+
Sbjct: 502 GPTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEG 561
Query: 619 -------QPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMP---APPHPRTPLGSPAAYW 668
+ E LR E P A+T P P PP P+ P S W
Sbjct: 562 EQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNW 621
Query: 669 KRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWE 728
K++G + CS +CGKG PIF C+ R + EE E C + +P EPC+ PCP +W+
Sbjct: 622 KQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWD 681
Query: 729 AGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEV 788
GEW+ CS++CG G QHRQ+ CRQ + +V P RC HL +P T +CQL++C W++
Sbjct: 682 IGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEWQI 741
Query: 789 GSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHS 848
+ W+ CSV CG GQR+R V+CV N GD V ++EC + +P E CDMGPC +WF +
Sbjct: 742 RTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEEC-NMKLRPNDIENCDMGPCAKSWFLT 800
Query: 849 DWSSKVSPE 857
+WS + S E
Sbjct: 801 EWSERCSAE 809
Score = 106 bits (264), Expect = 1e-22
Identities = 67/188 (35%), Positives = 89/188 (47%), Gaps = 13/188 (6%)
Query: 670 RVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEA 729
R ++CS CG G C+S G+ +D+ C RP E C PC W
Sbjct: 742 RTDWTSCSVPCGVGQRTRDVKCVSN-IGDVVDDEECNMKLRPN-DIENCDMGPCAKSWFL 799
Query: 730 GEWTS-CSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCG---H 785
EW+ CS CG G + R + C SS+P E CG+ RP C C
Sbjct: 800 TEWSERCSAECGAGVRTRSVVCMTNHV---SSLPLEGCGN-NRPAEATPCDNGPCTGKVE 855
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGD--EVSEQECASGPPQPPSREACDMGPCTT 843
W GS WSQCS+ CG G + R+V CV N D EV + S +PPS+++C + PC
Sbjct: 856 WFAGS-WSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGA 914
Query: 844 AWFHSDWS 851
WF ++WS
Sbjct: 915 KWFSTEWS 922
Score = 100 bits (249), Expect = 6e-21
Identities = 57/168 (33%), Positives = 77/168 (45%), Gaps = 8/168 (4%)
Query: 676 CSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPY--WEAGEWT 733
CSA CG GV +C++ L C G PA PC PC W AG W+
Sbjct: 806 CSAECGAGVRTRSVVCMTNHVSS-LPLEGC--GNNRPAEATPCDNGPCTGKVEWFAGSWS 862
Query: 734 SCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWS 793
CS CG GTQ R++ C ++ + P C L +P QSC L+ CG + WS
Sbjct: 863 QCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWS 922
Query: 794 QCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC 841
CS C G R R+VRC+ D+++ +P RE+C+ C
Sbjct: 923 MCSKSCQGGFRVREVRCL---SDDMTLSNLCDPQLKPEERESCNPQDC 967
Score = 60.8 bits (146), Expect = 5e-09
Identities = 34/118 (28%), Positives = 54/118 (45%), Gaps = 8/118 (6%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISR--ESGEELDERSCAAGARPPASPEPCHGTPCPP 725
W S CS CG G + +C+ + ++ E LD C+ +PP S + CH PC
Sbjct: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPP-SQQSCHLKPCGA 914
Query: 726 YWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC 783
W + EW+ CS+SC G + R+++C + C +P +SC + C
Sbjct: 915 KWFSTEWSMCSKSCQGGFRVREVRCLSD-----DMTLSNLCDPQLKPEERESCNPQDC 967
Score = 33.9 bits (76), Expect = 0.68
Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 6/53 (11%)
Query: 699 ELDERSCAAGARPPASPEPCHGTPCPPYWEA-GEWTSCSRSCGPGTQHRQLQC 750
++ +R A GA PE G P W A G W++CSRSC G + C
Sbjct: 33 KVPQRMAAEGA-----PEDDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRPC 80
Score = 30.0 bits (66), Expect = 9.8
Identities = 19/52 (36%), Positives = 22/52 (42%), Gaps = 4/52 (7%)
Query: 52 QWAS-CSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGP 102
+W+ CS CG GV+ RS C V SLPL P P GP
Sbjct: 801 EWSERCSAECGAGVRTRSVVCMTNHVS---SLPLEGCGNNRPAEATPCDNGP 849
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 290 bits (741), Expect = 5e-78
Identities = 160/493 (32%), Positives = 235/493 (47%), Gaps = 63/493 (12%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
C G S + C+ PC D RA QCA +NS+ F G YQW+P+T+V+ RC+L C+
Sbjct: 628 CPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCK 687
Query: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
F F+ + KV+DGT C P D+C+ G C GCD LGS D CGVC GD+ST
Sbjct: 688 AENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNST 747
Query: 484 CRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVD 543
C+ G ++ Y ++ IPAGA ++I +L+ SS+YLA+R + + G W++D
Sbjct: 748 CKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSID 807
Query: 544 PPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISSPP 603
PG + GT F Y R + E L A GPT + + ++ Q +NPG+ ++Y +
Sbjct: 808 WPGEFPFAGTTFEYQ---RSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYAL---- 860
Query: 604 PILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTPLGS 663
P+++ PP P
Sbjct: 861 ----------------PKVMNGTPPATKRP------------------------------ 874
Query: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPC 723
AY + S CS SCG G +C+ R+ +++ C+A +P P+ C+ C
Sbjct: 875 --AYTWSIVQSECSVSCGGGYINVKAICL-RDQNTQVNSSFCSAKTKPVTEPKICNAFSC 931
Query: 724 PPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC 783
P YW GEW++CS++C G Q R++QC Q+ + P Q+C C
Sbjct: 932 PAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHAC 991
Query: 784 -GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC- 841
W +G PWSQCS CGRG R R++ C G+ + + E +C S P+P +E C +G C
Sbjct: 992 PPQWSLG-PWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTS-LPRPELQEGCVLGRCP 1049
Query: 842 ---TTAWFHSDWS 851
W S WS
Sbjct: 1050 KNSRLQWVASSWS 1062
Score = 90.1 bits (222), Expect = 8e-18
Identities = 60/189 (31%), Positives = 85/189 (44%), Gaps = 21/189 (11%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPP-- 725
W S CS +CG+GV + LC + E L E C + RP E C CP
Sbjct: 995 WSLGPWSQCSKTCGRGVRKRELLC-KGSAAETLPESQCTSLPRPELQ-EGCVLGRCPKNS 1052
Query: 726 --YWEAGEWTSCSRSCGPGTQHRQLQCRQE-FGGGGSSVPPERCGHLPRPN--ITQSCQL 780
W A W+ CS +CG G + R+++C ++ F G + P RC ++ +PN + ++C
Sbjct: 1053 RLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNR 1112
Query: 781 RLCGHWEV--------GSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPS 832
R C V PW QC+V CG G ++R V CV S C +PP
Sbjct: 1113 RACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSS---CLL-HQKPPV 1168
Query: 833 REACDMGPC 841
AC+ C
Sbjct: 1169 LRACNTNFC 1177
Score = 38.5 bits (88), Expect = 0.028
Identities = 14/33 (42%), Positives = 19/33 (57%)
Query: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQ 77
G W W +W+ CS+ CG GV+ + R C P Q
Sbjct: 590 GQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ 622
Score = 37.0 bits (84), Expect = 0.080
Identities = 15/60 (25%), Positives = 28/60 (46%)
Query: 793 SQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSS 852
S+CSV CG G + + C+ + +V+ C++ + C+ C W +WS+
Sbjct: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWST 942
Score = 35.0 bits (79), Expect = 0.30
Identities = 25/89 (28%), Positives = 37/89 (41%), Gaps = 24/89 (26%)
Query: 715 PEPCHGTPCPPYWEA-GEWTSCSRSCGPGTQHRQLQC---RQEFGG---GGSSVPPERCG 767
P P HG W A +W+ CSR+CG G + ++ C + ++GG GSS
Sbjct: 585 PRPIHGQ-----WSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSS------- 632
Query: 768 HLPRPNITQSCQLRLCGHWEVGSPWSQCS 796
I Q C + C + QC+
Sbjct: 633 -----RIYQLCNINPCNENSLDFRAQQCA 656
Score = 33.5 bits (75), Expect = 0.89
Identities = 29/103 (28%), Positives = 39/103 (37%), Gaps = 25/103 (24%)
Query: 739 CGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVR 798
CG RQ QC +FG G PRP + G W S WS+CS
Sbjct: 566 CGLSMWCRQGQC-VKFGELG-----------PRP---------IHGQWSAWSKWSECSRT 604
Query: 799 CGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC 841
CG G + ++ C N + C P + C++ PC
Sbjct: 605 CGGGVKFQERHC-NNPKPQYGGLFC---PGSSRIYQLCNINPC 643
Score = 31.6 bits (70), Expect = 3.4
Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 8/48 (16%)
Query: 43 PEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHP-----SLPLP 85
P+ GPW Q CS+ CG GV++R C+ + P SLP P
Sbjct: 993 PQWSLGPWSQ---CSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRP 1037
Score = 30.8 bits (68), Expect = 5.7
Identities = 13/34 (38%), Positives = 19/34 (55%), Gaps = 2/34 (5%)
Query: 40 GQGPEGVWGPWV--QWASCSQPCGVGVQRRSRTC 71
G+ P+ WV W+ CS CG+GV++R C
Sbjct: 1046 GRCPKNSRLQWVASSWSECSATCGLGVRKREMKC 1079
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 272 bits (696), Expect = 9e-73
Identities = 176/559 (31%), Positives = 249/559 (44%), Gaps = 81/559 (14%)
Query: 313 GQGPWGTGG--TPHGPRLEPDPQHPGAWLPLLSNGP----------HASSLWSLFAPSSP 360
G W GG +G P P H G W S P H S L + PS
Sbjct: 564 GHDMWCRGGQCVKYGDE-GPKPTH-GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHG 621
Query: 361 IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL 420
C G + L+ C+ CP + D RA QCA NS+ F G+ Y+W+P+T+V+ C+L
Sbjct: 622 GKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKL 681
Query: 421 NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD 480
C GF F+ + KV+DGT C + ++C+ G C GCD +LGS D CGVC G+
Sbjct: 682 YCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGN 741
Query: 481 DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW 540
+S C + G T Y ++ IP+GA ++I ++ S++Y+++R R +NG+W
Sbjct: 742 NSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHW 801
Query: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
VD PG Y+ GT F Y R E E+L A GPT + + V ++FQ NPGV ++Y
Sbjct: 802 TVDWPGRYKFSGTTFDYRRSYNEP---ENLIATGPTNETLIVELLFQGRNPGVAWEY--- 855
Query: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
+P+L E +PP P
Sbjct: 856 -------------SMPRLGTE---KQPPAQP----------------------------- 870
Query: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
+Y + S CS SCG G C R+ +++ C RP PC
Sbjct: 871 -----SYTWAIVRSECSVSCGGGQMTVREGCY-RDLKFQVNMSFCNPKTRPVTGLVPCKV 924
Query: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL 780
+ CPP W G W++CSR+CG G Q R +QC + VP C P P+ Q+C
Sbjct: 925 SACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQ-PAPSSRQACNS 983
Query: 781 RLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGD---EVSEQECASGPPQPPSREAC 836
+ C W G PW++CS CG+G R R V C N ++ + P+P EAC
Sbjct: 984 QSCPPAWSAG-PWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
Query: 837 DMGPC----TTAWFHSDWS 851
+ C W S WS
Sbjct: 1043 LLQRCHKPKKLQWLVSAWS 1061
Score = 74.7 bits (182), Expect = 3e-13
Identities = 48/167 (28%), Positives = 74/167 (44%), Gaps = 25/167 (14%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEE---LDERSCAAGARPPASP----EPCHG 720
W + CS +CGKG + C S L + C + +P + CH
Sbjct: 990 WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCH- 1048
Query: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGG-SSVPPERCGHLPRPNIT--QS 777
P W W+ CS +C GTQ R L+C +++ G + ++C HLP+P++ ++
Sbjct: 1049 KPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERA 1108
Query: 778 CQLRLC-------------GHWEVGSPWSQCSVRCGRGQRSRQVRCV 811
C C G W SPWSQC+ CG G ++R V+C+
Sbjct: 1109 CAPLPCPRHPPFAAAGPSRGSW-FASPWSQCTASCGGGVQTRSVQCL 1154
Score = 52.4 bits (124), Expect = 2e-06
Identities = 37/132 (28%), Positives = 53/132 (40%), Gaps = 22/132 (16%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRE-SGE--ELDERSCAAGARPPASPE-PCHGTPC 723
W S CS +C +G + C + SG+ EL + C+ +P E C PC
Sbjct: 1055 WLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPC 1114
Query: 724 PPY------------WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPR 771
P + W A W+ C+ SCG G Q R +QC GG P C +
Sbjct: 1115 PRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQC---LAGGR---PASGCLLHQK 1168
Query: 772 PNITQSCQLRLC 783
P+ + +C C
Sbjct: 1169 PSASLACNTHFC 1180
Score = 42.4 bits (98), Expect = 0.002
Identities = 18/38 (47%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 38 EEGQGP-EGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
+EG P G W W W+ CS+ CG GV RSR C P
Sbjct: 579 DEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNP 616
Score = 32.3 bits (72), Expect = 2.0
Identities = 19/58 (32%), Positives = 25/58 (43%), Gaps = 8/58 (13%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLP-------PRPPRHPEALLPRGQGPR 103
WA CS CG G ++R+ C+ L LP P+P H LL R P+
Sbjct: 995 WAECSHTCGKGWRKRAVACKSTNPSARAQL-LPDAVCTSEPKPRMHEACLLQRCHKPK 1051
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 270 bits (690), Expect = 4e-72
Identities = 183/577 (31%), Positives = 253/577 (43%), Gaps = 73/577 (12%)
Query: 304 SVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLSNGPHASSLW----------- 352
S+P G Q TG G + D G W + G SLW
Sbjct: 523 SIPAAEGTLCQ----TGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGV 578
Query: 353 --SLFAPSSPIPR-----CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQ 405
SL SP P C GE ++ R+C+ PCP D R QCA F++ F G+ Y
Sbjct: 579 SSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYN 638
Query: 406 WEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGIL 465
W+P+T G + C LNC G+ FY V DGT C + DIC+ G C GCD IL
Sbjct: 639 WKPYTG-GGVKPCALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNIL 697
Query: 466 GSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYL 525
GS R D C VCGGD STC + G D GY +++ IP G++ +++ ++ S NY+
Sbjct: 698 GSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYI 757
Query: 526 ALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMI 585
AL+ G ING W +D P + GT F Y RP E ESL A GPT++ + V ++
Sbjct: 758 ALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEP---ESLEALGPTSENLIVMVL 814
Query: 586 FQEENPGVFYQYVISSPPPILENPTPEPPVP---QLQPEILRVEPPLAPAPRPARTPGTL 642
QE+N G+ Y++ + PI + + V QP + A G +
Sbjct: 815 LQEQNLGIRYKFNV----PITRTGSGDNEVGFTWNHQPW----------SECSATCAGGV 860
Query: 643 QRQVRI----------------PQMPAPPHPRTPLGSPA-AYWKRVGHSACSASCGKGVW 685
QRQ + P P + R P W CS +C G+
Sbjct: 861 QRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMR 920
Query: 686 RPIFLCISR---ESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPG 742
LCI + E LD C P EPC+ CPP W A +W+ C+ CGPG
Sbjct: 921 TRAVLCIRKIGPSEEETLDYSGCL--THRPVEKEPCNNQSCPPQWVALDWSECTPKCGPG 978
Query: 743 TQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC--GHWEVGSPWSQCSVRCG 800
+HR + C+ + P +C +P + C L C W G W QCS +CG
Sbjct: 979 FKHRIVLCKS--SDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGD-WGQCSAQCG 1035
Query: 801 RGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACD 837
GQ+ R V+C+ G + +C +PPS + C+
Sbjct: 1036 LGQQMRTVQCLSYTGQ--ASSDCLE-TVRPPSMQQCE 1069
Score = 98.6 bits (244), Expect = 2e-20
Identities = 51/184 (27%), Positives = 77/184 (41%), Gaps = 1/184 (0%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
W S CSA+C GV R +C + + C ++PP + C+ PCPP W
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEW 903
Query: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787
G+W CS++C G + R + C ++ G RP + C + C
Sbjct: 904 FIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQW 963
Query: 788 VGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC-TTAWF 846
V WS+C+ +CG G + R V C ++ + +PP R C +G C W
Sbjct: 964 VALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWV 1023
Query: 847 HSDW 850
DW
Sbjct: 1024 TGDW 1027
Score = 60.5 bits (145), Expect = 7e-09
Identities = 38/129 (29%), Positives = 54/129 (41%), Gaps = 7/129 (5%)
Query: 727 WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQ-SCQLRLCG- 784
W W+ CS +C G Q +++ C++ S V C +P Q +C C
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVCKRL--DDNSIVQNNYCDPDSKPPENQRACNTEPCPP 901
Query: 785 HWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASG--PPQPPSREACDMGPCT 842
W +G W +CS C G R+R V C+ G E SG +P +E C+ C
Sbjct: 902 EWFIGD-WLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCP 960
Query: 843 TAWFHSDWS 851
W DWS
Sbjct: 961 PQWVALDWS 969
Score = 42.0 bits (97), Expect = 0.002
Identities = 16/34 (47%), Positives = 18/34 (52%)
Query: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
Q +G WGPW W CS+ CG GV R C P
Sbjct: 555 QSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSP 588
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
7 preproprotein [Homo sapiens]
Length = 1686
Score = 263 bits (672), Expect = 5e-70
Identities = 165/485 (34%), Positives = 224/485 (46%), Gaps = 74/485 (15%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
C GE ++ R C+ CP +P R +QC+ F++ + GQL+ W P V CEL+CR
Sbjct: 577 CVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYKGQLHTWVPV--VNDVNPCELHCR 634
Query: 424 PRGFRFYVRHTEKVQDGTLCQP--GAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
P F + + V DGT C + D+C+ G C + GCD + SG D CGVC G+
Sbjct: 635 PANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNG 694
Query: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRS-IINGNW 540
STC VSG + G LGY + IPAGA ++I ++ ++N+LALR +NG W
Sbjct: 695 STCHTVSGTFEEAEG-LGYVDVGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGW 753
Query: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
+ G Y+ GT F Y R G E+L++ GPT +PV + ++FQE NPGV Y+Y
Sbjct: 754 TIQWNGDYQVAGTTFTYAR----RGNWENLTSPGPTKEPVWIQLLFQESNPGVHYEY--- 806
Query: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
T+ R+ A H P
Sbjct: 807 ----------------------------------------TIHRE-------AGGHDEVP 819
Query: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
P W + C+ +CG+GV R C+ R++G +DE C RP C
Sbjct: 820 --PPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGP-VDEEHCDPLGRPDDQQRKCSE 876
Query: 721 TPCPPYWEAGEWTSCSRSCGP-GTQHRQLQCRQEFG-GGGSSVPPERCGHLPRPNITQSC 778
PCP W AGEW CS SCGP G R + C + G S++ P C HLPRP C
Sbjct: 877 QPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPC 936
Query: 779 QLRL-C-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREAC 836
+ C W VG+ WSQCSV CG G + R V C + G E + QP S C
Sbjct: 937 NRHVPCPATWAVGN-WSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQ------QPASEVTC 989
Query: 837 DMGPC 841
+ C
Sbjct: 990 SLPLC 994
Score = 103 bits (256), Expect = 9e-22
Identities = 87/291 (29%), Positives = 107/291 (36%), Gaps = 70/291 (24%)
Query: 611 PEP---PVPQLQPEILRVEPPLA------PA-PRPARTPGTLQRQVRIPQMPAPPHPRTP 660
PEP P P+ QPE L E PL+ PA PA + + Q P + P P
Sbjct: 1348 PEPALNPGPKGQPESLSPEVPLSSRLLSTPAWDSPANSHRVPETQPLAPSLAEAGPPADP 1407
Query: 661 LGSPAAYWKRVGHSACSASCGKG-VWRPIFLCISRESGEELDERSCAAGARPPASPEPCH 719
L A W+ S CS +CG G VWRP+ R+ CA RP + CH
Sbjct: 1408 LVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDE-------DCAPAGRPQPARR-CH 1459
Query: 720 GTPCPPYWEAGEWTSCSRSCGPGTQHRQLQC----------------------------- 750
PC W +G W+ CSRSCG G+ R +QC
Sbjct: 1460 LRPCAT-WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGA 1518
Query: 751 -------------RQEFGGGG------SSVPPERCGHLPRPNITQSCQLRLCGHWEVGSP 791
E GGG + P C RPN T+ C C W VG P
Sbjct: 1519 QPCLSWYTSSWRECSEACGGGEQQRLVTCPEPGLCEEALRPNTTRPCNTHPCTQWVVG-P 1577
Query: 792 WSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECASGPPQPPSREACDMGPC 841
W QCS CG G + R V+CV G + + P S C C
Sbjct: 1578 WGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 51.2 bits (121), Expect = 4e-06
Identities = 31/96 (32%), Positives = 43/96 (44%), Gaps = 9/96 (9%)
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQEC-ASGPPQPPSREACDMGPCTTA 844
W G PW++C+V CGRG + + V C+ V E+ C G P R+ C PC
Sbjct: 825 WHYG-PWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRK-CSEQPCPAR 882
Query: 845 WFHSDW---SSKVSP---EPPAISCILGNHAQDTSA 874
W+ +W SS P A+ CI + SA
Sbjct: 883 WWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSA 918
Score = 41.6 bits (96), Expect = 0.003
Identities = 15/32 (46%), Positives = 19/32 (59%)
Query: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTCQLPT 75
+G W W W+ CS+ CG+GVQ R C PT
Sbjct: 538 DGGWSGWSAWSICSRSCGMGVQSAERQCTQPT 569
Score = 36.6 bits (83), Expect = 0.10
Identities = 21/63 (33%), Positives = 27/63 (42%), Gaps = 2/63 (3%)
Query: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESG-EELDERSCAAGARPPASPEPCHGTP 722
P W CS CG GV R + C++ ++G E D C A P +S PC
Sbjct: 1569 PCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESS-RPCGTED 1627
Query: 723 CPP 725
C P
Sbjct: 1628 CEP 1630
Score = 35.0 bits (79), Expect = 0.30
Identities = 31/93 (33%), Positives = 36/93 (38%), Gaps = 29/93 (31%)
Query: 668 WKRVG---HSACSAS-----CGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCH 719
W VG HS A+ CG+ W C+S E G RP A
Sbjct: 496 WCSVGTTCHSKLDAAVDGTRCGENKW-----CLSGEC--------VPVGFRPEAVDGGWS 542
Query: 720 GTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQ 752
G W A W+ CSRSCG G Q + QC Q
Sbjct: 543 G------WSA--WSICSRSCGMGVQSAERQCTQ 567
Score = 33.9 bits (76), Expect = 0.68
Identities = 22/57 (38%), Positives = 30/57 (52%), Gaps = 4/57 (7%)
Query: 15 LLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71
L++ P+ L +E L ++ + P + V GPW Q CS PCG GVQRR C
Sbjct: 1544 LVTCPEPGLCEEALRPNTTR-PCNTHPCTQWVVGPWGQ---CSGPCGGGVQRRLVKC 1596
Score = 30.4 bits (67), Expect = 7.5
Identities = 19/51 (37%), Positives = 23/51 (45%), Gaps = 2/51 (3%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRP-PRHPEALLPRGQGP 102
W+ CS+ CG G R C + T L P P +P P P A P G P
Sbjct: 1471 WSKCSRSCGGGSSVRDVQC-VDTRDLRPLRPFHCQPGPAKPPAHRPCGAQP 1520
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 261 bits (668), Expect = 2e-69
Identities = 165/492 (33%), Positives = 228/492 (46%), Gaps = 41/492 (8%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
C GE + R+C+ CPP D R +QC+ F+S F G+ Y+W+ + G + C L C
Sbjct: 586 CLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRG-GGVKACSLTCL 644
Query: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
GF FY V DGT C+P DICV+G C GCD +LGS R D C VCGGD S
Sbjct: 645 AEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSA 704
Query: 484 CRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVD 543
C + G + GY+ ++WIP G++ + I L S ++LAL+G ++ G
Sbjct: 705 CETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTP 764
Query: 544 PPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQY----VI 599
P GT F+ + P + +SL A GP + V ++ + E P + Y++
Sbjct: 765 QPHRLPLAGTTFQLRQGPDQV---QSLEALGPINASLIVMVLARTELPALRYRFNAPIAR 821
Query: 600 SSPPPILENPTPEPPV-------PQLQPEILRVE-PPLAPAPRPARTPGTL-QRQVRIPQ 650
S PP + P Q+Q R + A AP L +RQ
Sbjct: 822 DSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNT 881
Query: 651 MPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEE---LDERSCAA 707
P PP W S CS SC GV +C R S E LD+ +C
Sbjct: 882 EPCPPD-----------WVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ 930
Query: 708 GARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCG 767
RPP E CHG CPP W A +W+ C+ SCGPG +HR + C+ +++PP C
Sbjct: 931 -PRPPVL-EACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKS--ADHRATLPPAHCS 986
Query: 768 HLPRPNITQSCQLRLC--GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECAS 825
+P T C LR C W G W +CS +CG GQR R VRC + G + EC
Sbjct: 987 PAAKPPATMRCNLRRCPPARWVAGE-WGECSAQCGVGQRQRSVRCTSHTGQ--ASHECTE 1043
Query: 826 GPPQPPSREACD 837
+PP+ + C+
Sbjct: 1044 A-LRPPTTQQCE 1054
Score = 95.9 bits (237), Expect = 1e-19
Identities = 50/188 (26%), Positives = 75/188 (39%), Gaps = 1/188 (0%)
Query: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPC 723
P W + CSA C G C ++ + C+A ++ P C+ PC
Sbjct: 825 PPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPC 884
Query: 724 PPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC 783
PP W G W+ CSRSC G + R + C++ + PRP + ++C C
Sbjct: 885 PPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTC 944
Query: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTT 843
WS+C+ CG G R R V C + S +PP+ C++ C
Sbjct: 945 PPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPP 1004
Query: 844 A-WFHSDW 850
A W +W
Sbjct: 1005 ARWVAGEW 1012
Score = 79.7 bits (195), Expect = 1e-14
Identities = 48/133 (36%), Positives = 62/133 (46%), Gaps = 8/133 (6%)
Query: 724 PPY-WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCG-HLPRPNITQSCQLR 781
PPY W WT CS C G+Q + ++CR + S+V P C H P ++C
Sbjct: 825 PPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDS--SAVAPHYCSAHSKLPKRQRACNTE 882
Query: 782 LCG-HWEVGSPWSQCSVRCGRGQRSRQVRCVG--NNGDEVSEQECASGPPQPPSREACDM 838
C W VG+ WS CS C G RSR V C + +E + + A P+PP EAC
Sbjct: 883 PCPPDWVVGN-WSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHG 941
Query: 839 GPCTTAWFHSDWS 851
C W DWS
Sbjct: 942 PTCPPEWAALDWS 954
Score = 48.1 bits (113), Expect = 3e-05
Identities = 17/34 (50%), Positives = 20/34 (58%)
Query: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
+G +G WGPW W CS+ CG GV SR C P
Sbjct: 544 EGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSP 577
Score = 33.9 bits (76), Expect = 0.68
Identities = 21/62 (33%), Positives = 26/62 (41%), Gaps = 3/62 (4%)
Query: 50 WV--QWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQTS 107
WV +W CS CGVG ++RS C T Q RPP + + P P
Sbjct: 1007 WVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPT-TQQCEAKCDSPTPGDG 1065
Query: 108 PE 109
PE
Sbjct: 1066 PE 1067
Score = 30.4 bits (67), Expect = 7.5
Identities = 22/68 (32%), Positives = 26/68 (38%), Gaps = 7/68 (10%)
Query: 29 SGHSLQTPTEEGQGPEGVWGPWV--QWASCSQPCGVGVQRRSRTCQ-----LPTVQLHPS 81
S HS + E WV W+ CS+ C GV+ RS CQ L S
Sbjct: 867 SAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDS 926
Query: 82 LPLPPRPP 89
PRPP
Sbjct: 927 ACPQPRPP 934
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 251 bits (640), Expect = 3e-66
Identities = 167/537 (31%), Positives = 248/537 (46%), Gaps = 69/537 (12%)
Query: 347 HASSLWSLFAP-------------------SSPIPRCSGESEQLRACSQAPCPPEQPDPR 387
H + WSL++P S C+G +Q R C PCP P R
Sbjct: 634 HLAGEWSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICENPPCPAGLPGFR 693
Query: 388 ALQCAAFNSQEFMGQ-LYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPG 446
QC A++ + + + QW+ + + + C L C P G + +EKV DGT C
Sbjct: 694 DWQCQAYSVRTSSPKHILQWQAVLDEE--KPCALFCSPVGKEQPILLSEKVMDGTSCGYQ 751
Query: 447 APDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWI 506
DIC GRC GCDG+LGS R D CGVC G+ +C+++ G+ G GY ++L I
Sbjct: 752 GLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRG-AGYVEVLVI 810
Query: 507 PAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGK 566
PAGA R+++ + +P+ +YLALR G +S IN +W ++ G++ GT Y R G
Sbjct: 811 PAGARRIKVVEEKPAHSYLALRDAGKQS-INSDWKIEHSGAFNLAGTTVHYVR----RGL 865
Query: 567 GESLSAEGPTTQPVD-VYMIFQEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRV 625
E +SA+GPTT P+ + ++FQ++N G+ Y+Y I S P+ EN + + P P
Sbjct: 866 WEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPS-DPLPENQSSKAPEPLFMWTHTSW 924
Query: 626 EPPLAPAPRPARTPGT-----LQRQVRIPQ--------MPAPPHPRTPLGSPAAYWKRVG 672
E A R + + + I P P + W
Sbjct: 925 EDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTE 984
Query: 673 HSACSASCGKGVWRPIFLCISRESGEEL---DERSCAAGARPPASPEPCHGTPCPPYWEA 729
+ CS +CGKG+ C + S L ER C PAS + C G C WEA
Sbjct: 985 WTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCI--GPKPASAQRCEGQDCMTVWEA 1042
Query: 730 GEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQ-LRLCGHWEV 788
G W+ CS CG G +HR ++C P ++C RP + C+ C W +
Sbjct: 1043 GVWSECSVKCGKGIRHRTVRCTN---------PRKKCVLSTRPREAEDCEDYSKCYVWRM 1093
Query: 789 GSPWSQCSVRCGRGQRSRQVRCV----GNNGDEVSEQECASGPPQPPSREACDMGPC 841
G WS+CS+ CG+G +SR ++C+ G +G+E E +P + C + PC
Sbjct: 1094 GD-WSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSE------KPAAYRPCHLQPC 1143
Score = 36.2 bits (82), Expect = 0.14
Identities = 13/35 (37%), Positives = 17/35 (48%)
Query: 37 TEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71
T PE + G W W+ CS+ C G+ R R C
Sbjct: 626 TSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKC 660
Score = 31.2 bits (69), Expect = 4.4
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 39 EGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
EGQ VW V W+ CS CG G++ R+ C P
Sbjct: 1032 EGQDCMTVWEAGV-WSECSVKCGKGIRHRTVRCTNP 1066
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 213 bits (541), Expect = 8e-55
Identities = 156/510 (30%), Positives = 207/510 (40%), Gaps = 94/510 (18%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
C G + R+C CP D RA QCA F+ EF G+ Y+W P+ +CELNC
Sbjct: 64 CVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPY--YSAPNKCELNCI 121
Query: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
P+G FY +H E V DGT C+PG D+CV G C GCD L S ++ D C CGGD +T
Sbjct: 122 PKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTT 181
Query: 484 CRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVD 543
C V+G A L + +R G +NG+W ++
Sbjct: 182 CYPVAGTFD---------------ANDLSRAVKNVR------------GEYYLNGHWTIE 214
Query: 544 PPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISSPP 603
+ A T+ Y R + E L A GPT++P+ + +I QE NPGV Y+Y +
Sbjct: 215 AARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELISQEPNPGVHYEYHLP--- 271
Query: 604 PILENPTPEPPVP---------------QLQPEILRVEPPLAPAPRPARTPGTLQRQVRI 648
L P+P Q + ++ P R P R+
Sbjct: 272 --LRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRR--- 326
Query: 649 PQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESG---EELDERSC 705
P P T WK + CSASCG G CIS + E ++E C
Sbjct: 327 -SCNLHPCPETKR------WKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAEC 379
Query: 706 AAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPER 765
A P + + C+ C W W CS SCG G + R + CR G GS +
Sbjct: 380 AGLPGKPPAIQACNLQRCAA-WSPEPWGECSVSCGVGVRKRSVTCR---GERGSLLHTAA 435
Query: 766 CGHLPRPNITQSCQLRLCG-----HWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSE 820
C RP +T+ C C W VG+ W CS C G R RQV
Sbjct: 436 CSLEDRPPLTEPCVHEDCPLLSDQAWHVGT-WGLCSKSCSSGTRRRQV------------ 482
Query: 821 QECASGPP---------QPPSREACDMGPC 841
CA GPP +P E C+ PC
Sbjct: 483 -ICAIGPPSHCGSLQHSKPVDVEPCNTQPC 511
Score = 42.7 bits (99), Expect = 0.001
Identities = 15/25 (60%), Positives = 17/25 (68%)
Query: 47 WGPWVQWASCSQPCGVGVQRRSRTC 71
WGPW QW+ CS+ CG GV R R C
Sbjct: 29 WGPWSQWSPCSRTCGGGVSFRERPC 53
Score = 38.5 bits (88), Expect = 0.028
Identities = 35/129 (27%), Positives = 50/129 (38%), Gaps = 26/129 (20%)
Query: 731 EWTSCSRSCGPGTQHRQLQC-RQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVG 789
+W+ CSR+CG G R+ C Q GG S V P R +SC+ C
Sbjct: 34 QWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARS--------HRSCRTESCPDGARD 85
Query: 790 SPWSQCSVRCG---RGQRSR-----------QVRCV--GNNGDEVSEQECASGPP-QPPS 832
QC+ G +G+R R ++ C+ G N + G P +P
Sbjct: 86 FRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPGK 145
Query: 833 REACDMGPC 841
R+ C G C
Sbjct: 146 RDVCVDGSC 154
Score = 35.8 bits (81), Expect = 0.18
Identities = 64/239 (26%), Positives = 88/239 (36%), Gaps = 33/239 (13%)
Query: 47 WGPWVQWASCSQPCGVGVQRRSRTCQLPTVQL--HPSLPLPPRPPR-----HPEALLPRG 99
W P W CS CGVGV++RS TC+ L + L RPP H + L
Sbjct: 400 WSP-EPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSD 458
Query: 100 QGPRPQTSPETLPLYRTQSRGRGGPLR-GPASHLGREETQEIRAARRSRLRDPIKPGMFG 158
Q T + +R R GP SH G + + S+ D ++P
Sbjct: 459 QAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCG--------SLQHSKPVD-VEPCNTQ 509
Query: 159 YGRVPFALPLHRNRRHPRSPP-----RSELSLISSRGE--EAIPSPTPRAEPFSANGSPQ 211
+P +P ++ P S P E SRG+ A P+ R + G P+
Sbjct: 510 PCHLPQEVPSMQDVHTPASNPWMPLGPQESPASDSRGQWWAAQEHPSARGDHRGERGDPR 569
Query: 212 TELPPTELSVHTPSPQAEPLSPETAQTEVAPRTRPAPLRHHPRAQASGTEPPSPTHSLG 270
+ T LS P+P L Q + + P RH P G P T SLG
Sbjct: 570 GD-QGTHLSALGPAPS---LQQPPYQQPLRSGSGPHDCRHSPH----GCCPDGHTASLG 620
>gi|226442878 ADAMTS-like 5 [Homo sapiens]
Length = 471
Score = 209 bits (533), Expect = 7e-54
Identities = 129/341 (37%), Positives = 169/341 (49%), Gaps = 31/341 (9%)
Query: 333 QHPGAWLPLLS---------NGPHASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQ 383
Q PG W P +S G S L P C G+S + R C CPP
Sbjct: 33 QGPGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPGEE--PCWGDSHEYRLCQLPDCPPGA 90
Query: 384 PDPRALQCAAFNSQEFMG--QLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGT 441
R LQCA +N + +G + YQW PF +C+LNC G FY +V DGT
Sbjct: 91 VPFRDLQCALYNGRPVLGTQKTYQWVPFHGAPN--QCDLNCLAEGHAFY-HSFGRVLDGT 147
Query: 442 LCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQ 501
C PGA +CVAGRCLS GCDG+LGSG D CG CGG + +C V D G GY
Sbjct: 148 ACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYW 207
Query: 502 KILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPP 561
+ IP GA +++ S N+LAL G GR ++NG+W V PPG+Y A GT Y
Sbjct: 208 NVTLIPEGARHIRVE--HRSRNHLALMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYT--- 262
Query: 562 REEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISS---PPPILENPTPEPPVPQL 618
R+ G E+L A GPT+ + + ++ QE NPG+ +++ + P P+ Q
Sbjct: 263 RDTGPQETLQAAGPTSHDLLLQVLLQEPNPGIEFEFWLPRERYSPFQARVQALGWPLRQP 322
Query: 619 QPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRT 659
QP + +PP APA PA+TP + P PP P T
Sbjct: 323 QPRGVEPQPPAAPAVTPAQTP-------TLAPDPCPPCPDT 356
Score = 44.7 bits (104), Expect = 4e-04
Identities = 19/31 (61%), Positives = 19/31 (61%), Gaps = 1/31 (3%)
Query: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71
QGP G W PWV W CS CG GV RSR C
Sbjct: 33 QGP-GEWTPWVSWTRCSSSCGRGVSVRSRRC 62
Score = 34.3 bits (77), Expect = 0.52
Identities = 20/62 (32%), Positives = 27/62 (43%), Gaps = 14/62 (22%)
Query: 770 PRPNITQSCQLRLC--------------GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG 815
PRP++ Q+ L L G W W++CS CGRG R RC+ G
Sbjct: 8 PRPHLFQNLLLFLWALLNCGLGVSAQGPGEWTPWVSWTRCSSSCGRGVSVRSRRCLRLPG 67
Query: 816 DE 817
+E
Sbjct: 68 EE 69
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 202 bits (514), Expect = 1e-51
Identities = 144/496 (29%), Positives = 197/496 (39%), Gaps = 101/496 (20%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFN--SQEFMGQLYQWEPFTEVQGSQRCELN 421
C G S + C PCP P R QC A + S + G L V + CEL
Sbjct: 582 CPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLT-----AVVVDDKPCELY 636
Query: 422 CRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
C P G + ++V DGT C P D+CV G+C GCDGI+GS + D CGVC GD
Sbjct: 637 CSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDG 696
Query: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWA 541
TC LV G+ + G AL+ G+ IN +W
Sbjct: 697 KTCHLVKGDFSHARGT----------------------------ALKD-SGKGSINSDWK 727
Query: 542 VDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVY-MIFQEENPGVFYQYVIS 600
++ PG ++ GT RY R G E +SA+GPT P+ + ++F +++ G+ Y+Y +
Sbjct: 728 IELPGEFQIAGTTVRYVR----RGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVP 783
Query: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
PE P L
Sbjct: 784 VNRTAENQSEPEKPQDSL------------------------------------------ 801
Query: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLC--ISRESGEELDERSCAAGARPPASPEPC 718
W G CS CG G R I C I ++ +++ C +RP C
Sbjct: 802 -----FIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRC 856
Query: 719 HGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGS-SVPPERCGHLPRPNITQS 777
+ PC W AG W+ CS +C G QHR++ C + G + P C PRP QS
Sbjct: 857 NLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG-PRPAAVQS 915
Query: 778 CQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREAC 836
C+ + C WE S WSQCS CG+G R V C + G +P + EAC
Sbjct: 916 CEGQDCLSIWE-ASEWSQCSASCGKGVWKRTVACTNSQGK-------CDASTRPRAEEAC 967
Query: 837 DMGPCTTAWFHSDWSS 852
+ W DWS+
Sbjct: 968 EDYSGCYEWKTGDWST 983
Score = 70.9 bits (172), Expect = 5e-12
Identities = 39/116 (33%), Positives = 53/116 (45%), Gaps = 12/116 (10%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
W+ S CSASCGKGVW+ C + + C A RP A E C W
Sbjct: 925 WEASEWSQCSASCGKGVWKRTVACTNSQG-------KCDASTRPRAE-EACEDYSGCYEW 976
Query: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC 783
+ G+W++CS +CG G Q R +QC + G S C L +P + C +C
Sbjct: 977 KTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGS----ECPALSKPAPYRQCYQEVC 1028
Score = 41.2 bits (95), Expect = 0.004
Identities = 14/31 (45%), Positives = 18/31 (58%)
Query: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
+G W PW W+ CS+ CG G + R R C P
Sbjct: 543 DGDWSPWGAWSMCSRTCGTGARFRQRKCDNP 573
Score = 39.7 bits (91), Expect = 0.012
Identities = 28/88 (31%), Positives = 39/88 (44%), Gaps = 8/88 (9%)
Query: 702 ERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGG----- 756
++ C AG +P P H W G W+ CSR+CG G + RQ +C G
Sbjct: 524 DKWCRAGECVSKTPIPEHVDGDWSPW--GAWSMCSRTCGTGARFRQRKCDNPPPGPGGTH 581
Query: 757 -GGSSVPPERCGHLPRPNITQSCQLRLC 783
G+SV C +LP P S + + C
Sbjct: 582 CPGASVEHAVCENLPCPKGLPSFRDQQC 609
Score = 33.5 bits (75), Expect = 0.89
Identities = 13/27 (48%), Positives = 14/27 (51%)
Query: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRC 810
G W WS CS CG G R RQ +C
Sbjct: 544 GDWSPWGAWSMCSRTCGTGARFRQRKC 570
Score = 30.0 bits (66), Expect = 9.8
Identities = 13/33 (39%), Positives = 18/33 (54%), Gaps = 1/33 (3%)
Query: 39 EGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71
EGQ +W +W+ CS CG GV +R+ C
Sbjct: 917 EGQDCLSIWEA-SEWSQCSASCGKGVWKRTVAC 948
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 196 bits (497), Expect = 1e-49
Identities = 160/541 (29%), Positives = 234/541 (43%), Gaps = 64/541 (11%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFM--GQL--YQWEP-FTEVQGSQRC 418
C G + ++C+ PC ++ D R QCA F+ + F G L +W P ++ + RC
Sbjct: 627 CVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRC 686
Query: 419 ELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCG 478
+L CR G Y + ++V DGT C DICV G C GCD +L S R D CGVCG
Sbjct: 687 KLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCG 746
Query: 479 GDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPS-----SNYLALRGPGGR 533
GD+S+C+ V+G T GY ++ IPAGA + + Q S NYLAL G
Sbjct: 747 GDNSSCKTVAG--TFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGE 804
Query: 534 SIINGNWAVD-PPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQP--VDVYMIFQEEN 590
++NGN+ V R G V Y+ E E +++ Q + V + + N
Sbjct: 805 FLLNGNFVVTMAKREIRIGNAVVEYS---GSETAVERINSTDRIEQELLLQVLSVGKLYN 861
Query: 591 PGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQV---- 646
P V Y + I PI + P Q P +P + G +R++
Sbjct: 862 PDVRYSFNI----PIEDKP---------QQFYWNSHGPWQACSKPCQ--GERKRKLVCTR 906
Query: 647 ----------RIPQMPAPPHPRTPLGSPA-AYWKRVGHSACSASCGKGVWRPIFLC--IS 693
R ++P P H P G+ W S CSA CG G C S
Sbjct: 907 ESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYS 966
Query: 694 RESG--EELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCR 751
R G E++D+ C++ + P++ E C G W WT CS+SC GTQ R+ C
Sbjct: 967 RLDGKTEKVDDGFCSSHPK-PSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAIC- 1024
Query: 752 QEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCV 811
+ +C H + I Q C C W+ G WS+C V CG+G + RQV C
Sbjct: 1025 --VNTRNDVLDDSKCTHQEKVTI-QRCSEFPCPQWKSGD-WSECLVTCGKGHKHRQVWCQ 1080
Query: 812 GNNGDEVSEQECASGPPQPPSREACDMGPCTT----AWFHSDWSSKVSPEPPAISCILGN 867
D ++++ C +P S + C C + W + + A+ CI+G
Sbjct: 1081 FGE-DRLNDRMC-DPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGT 1138
Query: 868 H 868
+
Sbjct: 1139 Y 1139
Score = 114 bits (284), Expect = 5e-25
Identities = 65/192 (33%), Positives = 84/192 (43%), Gaps = 21/192 (10%)
Query: 666 AYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARP-------------- 711
A W+ CS +CG+G CI +D+ C A RP
Sbjct: 1109 ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPP 1168
Query: 712 PASPEPCHGTPCPP--YWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHL 769
PA+PE T P W G WT CS +CG GT+ R + CR E GS C L
Sbjct: 1169 PAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDE---NGSVADESACATL 1225
Query: 770 PRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQ 829
PRP + C + CG W+ WS CSV CG+G+ +RQV CV + + EC
Sbjct: 1226 PRPVAKEECSVTPCGQWK-ALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSEC-DQDYI 1283
Query: 830 PPSREACDMGPC 841
P + + C M PC
Sbjct: 1284 PETDQDCSMSPC 1295
Score = 104 bits (260), Expect = 3e-22
Identities = 70/209 (33%), Positives = 95/209 (45%), Gaps = 14/209 (6%)
Query: 653 APPHP-RTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARP 711
A PH R G WK S CS SCG+GV + C + + E C RP
Sbjct: 1485 AKPHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGC-QIGTHKIARETECNPYTRP 1543
Query: 712 PASPEPCHGTPCPPY-WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLP 770
S C G CP Y W A EW C+++CG G+++R++ C + + V RC
Sbjct: 1544 E-SERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDD---NKNEVHGARCDVSK 1599
Query: 771 RPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRC----VGNNGDEVSEQECASG 826
RP +SC L+ C + + WS+CSV CG+G + R V C G E S Q +
Sbjct: 1600 RPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINC 1659
Query: 827 P-PQPPSREACDMGPC--TTAWFHSDWSS 852
P QPPS C + C + W +W S
Sbjct: 1660 PGTQPPSVHPCYLRDCPVSATWRVGNWGS 1688
Score = 101 bits (251), Expect = 3e-21
Identities = 74/273 (27%), Positives = 109/273 (39%), Gaps = 28/273 (10%)
Query: 619 QPEILRVEPPLAPAPRPARTPGT------LQRQVRIPQMPAPPHPRTPLGSPAAYWKRVG 672
Q I + + +P P RTP + Q + P+ +P G+ W+
Sbjct: 1280 QDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQ---WRTGP 1336
Query: 673 HSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEW 732
ACS++C G R + +C E+G ++ C +P C PCP W G W
Sbjct: 1337 WGACSSTCAGGSQRRVVVC-QDENGYTAND--CVERIKPDEQ-RACESGPCPQ-WAYGNW 1391
Query: 733 TSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGH---WEVG 789
C++ CG G + R + C++ G P C L +P + C C H W G
Sbjct: 1392 GECTKLCGGGIRTRLVVCQRS---NGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTG 1448
Query: 790 SPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC----TTAW 845
PWS CSV CGRG + R V C+ +G + C +P C G C AW
Sbjct: 1449 -PWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYC-KHLAKPHGHRKCRGGRCPKWKAGAW 1506
Query: 846 FHSDWSSKVSPEPPAISCILGNH--AQDTSAFP 876
S + + C +G H A++T P
Sbjct: 1507 SQCSVSCGRGVQQRHVGCQIGTHKIARETECNP 1539
Score = 100 bits (249), Expect = 6e-21
Identities = 53/175 (30%), Positives = 87/175 (49%), Gaps = 11/175 (6%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
W+ + CS SC G R +C++ + + LD+ C + + + C PCP W
Sbjct: 1001 WRYSAWTECSKSCDGGTQRRRAICVNTRN-DVLDDSKCTHQEK--VTIQRCSEFPCPQ-W 1056
Query: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787
++G+W+ C +CG G +HRQ+ C+ G + C +P Q+CQ C W+
Sbjct: 1057 KSGDWSECLVTCGKGHKHRQVWCQF----GEDRLNDRMCDPETKPTSMQTCQQPECASWQ 1112
Query: 788 VGSPWSQCSVRCGRGQRSRQVRC-VGNNGDEVSEQECASGPPQPPSREACDMGPC 841
G PW QCSV CG+G + R V+C +G V + +C + +P + C++ C
Sbjct: 1113 AG-PWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDC-NAATRPTDTQDCELPSC 1165
Score = 94.7 bits (234), Expect = 3e-19
Identities = 67/236 (28%), Positives = 91/236 (38%), Gaps = 45/236 (19%)
Query: 649 PQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAG 708
P AP R+ +P W+ + CSA+CGKG R ++ E+G DE +CA
Sbjct: 1167 PPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGT-RMRYVSCRDENGSVADESACATL 1225
Query: 709 ARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGH 768
RP A E C TPC W+A +W+SCS +CG G RQ+ C + C
Sbjct: 1226 PRPVAK-EECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMC---VNYSDHVIDRSECDQ 1280
Query: 769 LPRPNITQSCQLRLC----------------------------------GHWEVGSPWSQ 794
P Q C + C W G PW
Sbjct: 1281 DYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTG-PWGA 1339
Query: 795 CSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDW 850
CS C G + R V C NG + +C +P + AC+ GPC W + +W
Sbjct: 1340 CSSTCAGGSQRRVVVCQDENG--YTANDCVE-RIKPDEQRACESGPC-PQWAYGNW 1391
Score = 92.0 bits (227), Expect = 2e-18
Identities = 63/248 (25%), Positives = 100/248 (40%), Gaps = 44/248 (17%)
Query: 640 GTLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEE 699
G++ + +P P +P WK + S+CS +CG+G +C++ S
Sbjct: 1214 GSVADESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVN-YSDHV 1272
Query: 700 LDERSCAAGARPPASPEPCHGTPCP-----------PY---------------------- 726
+D C P + + C +PCP P+
Sbjct: 1273 IDRSECDQD-YIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQ 1331
Query: 727 WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHW 786
W G W +CS +C G+Q R + C+ E G + C +P+ ++C+ C W
Sbjct: 1332 WRTGPWGACSSTCAGGSQRRVVVCQDENGYTAND-----CVERIKPDEQRACESGPCPQW 1386
Query: 787 EVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC--TTA 844
G+ W +C+ CG G R+R V C +NG+ + C +PP RE C+ C A
Sbjct: 1387 AYGN-WGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEI-LDKPPDREQCNTHACPHDAA 1444
Query: 845 WFHSDWSS 852
W WSS
Sbjct: 1445 WSTGPWSS 1452
Score = 78.2 bits (191), Expect = 3e-14
Identities = 55/187 (29%), Positives = 78/187 (41%), Gaps = 18/187 (9%)
Query: 657 PRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPE 716
PR PL + W+ C+ +CG+G +C+ ++ E+ C RP E
Sbjct: 1552 PRCPLYT----WRAEEWQECTKTCGEGSRYRKVVCVD-DNKNEVHGARCDVSKRP-VDRE 1605
Query: 717 PCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGG----SSVPPERCGHLPRP 772
C PC W GEW+ CS +CG G + R + C + + G S C P
Sbjct: 1606 SCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPP 1665
Query: 773 NITQSCQLRLC---GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQ 829
++ C LR C W VG+ W CSV CG G R V+C+ N E +
Sbjct: 1666 SV-HPCYLRDCPVSATWRVGN-WGSCSVSCGVGVMQRSVQCLTN---EDQPSHLCHTDLK 1720
Query: 830 PPSREAC 836
P R+ C
Sbjct: 1721 PEERKTC 1727
Score = 35.8 bits (81), Expect = 0.18
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
+G WG W + +CS+ CG G++ R C P
Sbjct: 588 DGSWGSWSPFGTCSRTCGGGIKTAIRECNRP 618
Score = 31.6 bits (70), Expect = 3.4
Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 7/53 (13%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPP--RPPRHPEALLPRGQGPR 103
W+ CS CG GVQ+R CQ+ T ++ P RP + QGPR
Sbjct: 1506 WSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDC-----QGPR 1553
Score = 31.2 bits (69), Expect = 4.4
Identities = 12/19 (63%), Positives = 13/19 (68%)
Query: 53 WASCSQPCGVGVQRRSRTC 71
W SCS CGVGV +RS C
Sbjct: 1686 WGSCSVSCGVGVMQRSVQC 1704
Score = 30.8 bits (68), Expect = 5.7
Identities = 15/49 (30%), Positives = 22/49 (44%), Gaps = 3/49 (6%)
Query: 34 QTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPSL 82
Q E G P+ +G W C++ CG G++ R CQ + P L
Sbjct: 1375 QRACESGPCPQWAYG---NWGECTKLCGGGIRTRLVVCQRSNGERFPDL 1420
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 191 bits (486), Expect = 2e-48
Identities = 146/532 (27%), Positives = 219/532 (41%), Gaps = 80/532 (15%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEF----MGQLYQWEP-FTEVQGSQRC 418
C G + R+C+ CP D R QC+ FN + + +W P ++ + RC
Sbjct: 595 CVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRC 654
Query: 419 ELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCG 478
+L C+ G ++ + V+DGT C DICV G+C++ GCD +L S + D CGVCG
Sbjct: 655 KLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCG 714
Query: 479 GDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQL----RPSSNYLALRGPGGRS 534
GD+S+C+ ++G GY ++ IPAGA + I Q +P +YLAL G
Sbjct: 715 GDNSSCKTITG--VFNSSHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNF 772
Query: 535 IINGNWAVDPPG---SYRAGGTVFRYNRPPREEGKGESLSAEGPTTQP-----VDVYMIF 586
+ NGN+ + + + TV Y+ G ++ T + + V +
Sbjct: 773 LFNGNFLLSTSKKEINVQGTRTVIEYS------GSNNAVERINSTNRQEKELILQVLCVG 826
Query: 587 QEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQ- 645
NP V Y + +P + + P P + LQR+
Sbjct: 827 NLYNPDVHYSF----------------NIPLEERSDMFTWDPYGPWEGCTKMCQGLQRRN 870
Query: 646 --------------VRIPQMPAPPHPRTPLGSPAAY-WKRVGHSACSASCGKGVWRPIFL 690
+P P + W +G S CS+ CG+G
Sbjct: 871 ITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHVIGKSECSSQCGQGYRTLDIH 930
Query: 691 CISRESGE----ELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHR 746
C+ E ++D+ C +PP + E CHG W EW+ CSRSCG G + R
Sbjct: 931 CMKYSIHEGQTVQVDDHYCGDQLKPP-TQELCHGNCVFTRWHYSEWSQCSRSCGGGERSR 989
Query: 747 QLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSR 806
+ C F G + C L R ++C C W S WS+C V CG+G + R
Sbjct: 990 ESYCMNNF---GHRLADNECQELSRVT-RENCNEFSCPSW-AASEWSECLVTCGKGTKQR 1044
Query: 807 QVRCVGNNGDEVSEQECASGPPQPPSREACDM-----------GPCTTAWFH 847
QV C N D +S+ C S +P S C++ GPCTT H
Sbjct: 1045 QVWC-QLNVDHLSDGFCNSS-TKPESLSPCELHTCASWQVGPWGPCTTTCGH 1094
Score = 99.8 bits (247), Expect = 1e-20
Identities = 63/224 (28%), Positives = 90/224 (40%), Gaps = 33/224 (14%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
W S CS SCG G C++ G L + C +R + E C+ CP W
Sbjct: 970 WHYSEWSQCSRSCGGGERSRESYCMNN-FGHRLADNECQELSR--VTRENCNEFSCPS-W 1025
Query: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787
A EW+ C +CG GT+ RQ+ C+ + C +P C+L C W+
Sbjct: 1026 AASEWSECLVTCGKGTKQRQVWCQLNV----DHLSDGFCNSSTKPESLSPCELHTCASWQ 1081
Query: 788 VGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCT----- 842
VG PW C+ CG G + R V+CV V E +P R++C + PC+
Sbjct: 1082 VG-PWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKL 1140
Query: 843 -------------TAWFHSDWSSKVSPEPPAISCILGNHAQDTS 873
W H W+ P ++SC G A+ S
Sbjct: 1141 ETALLPTVLIKKMAQWRHGSWT------PCSVSCGRGTQARYVS 1178
Score = 96.7 bits (239), Expect = 9e-20
Identities = 64/209 (30%), Positives = 84/209 (40%), Gaps = 27/209 (12%)
Query: 666 AYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCP- 724
A W+ C+ +CG G C++ + L++ C +RP + + C TPC
Sbjct: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRP-SDRQSCVLTPCSF 1136
Query: 725 -----------------PYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCG 767
W G WT CS SCG GTQ R + CR C
Sbjct: 1137 ISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDAL---DRIADESYCA 1193
Query: 768 HLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGP 827
HLPRP C CG W+ G WS CS CG G+ +RQV C+ N + E C
Sbjct: 1194 HLPRPAEIWDC-FTPCGEWQAGD-WSPCSASCGHGKTTRQVLCM-NYHQPIDENYC-DPE 1249
Query: 828 PQPPSREACDMGPCTTAWFHSDWSSKVSP 856
+P + C + C A H SS V P
Sbjct: 1250 VRPLMEQECSLAACPPAHSHFP-SSPVQP 1277
Score = 94.7 bits (234), Expect = 3e-19
Identities = 55/190 (28%), Positives = 87/190 (45%), Gaps = 9/190 (4%)
Query: 654 PPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPA 713
PP + P W CS +CG G+ + +C +G+ L++ +C +PP+
Sbjct: 1348 PPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVIC-QFPNGQILEDHNCEIVNKPPS 1406
Query: 714 SPEPCHGTPCPP--YWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPR 771
+ CH CP W WTSCS SCG G ++R++ C +F + C + +
Sbjct: 1407 VIQ-CHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQF---QRKLEDTNCSQVQK 1462
Query: 772 PNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPP 831
P ++C+ C W+ S W++CSV CG G + R V C +V E+ C +P
Sbjct: 1463 PPTHKACRSVRCPSWKANS-WNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQS-TRPC 1520
Query: 832 SREACDMGPC 841
S+ C C
Sbjct: 1521 SQRRCWSQDC 1530
Score = 92.0 bits (227), Expect = 2e-18
Identities = 67/233 (28%), Positives = 84/233 (36%), Gaps = 53/233 (22%)
Query: 663 SPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTP 722
+P W+ S CSASCG G LC++ + +DE C RP E C
Sbjct: 1206 TPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYH--QPIDENYCDPEVRPLMEQE-CSLAA 1262
Query: 723 CPP-----------------------------------------YWEAGEWTSCSRSCGP 741
CPP W G W SCS SC
Sbjct: 1263 CPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSG 1322
Query: 742 GTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGR 801
G QHR + C+ E G S C +P Q C C W G+ W +CS CG
Sbjct: 1323 GLQHRAVVCQDENGQSAS-----YCDAASKPPELQQCGPGPCPQWNYGN-WGECSQTCGG 1376
Query: 802 GQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC--TTAWFHSDWSS 852
G +SR V C NG + + C +PPS C M C +W W+S
Sbjct: 1377 GIKSRLVICQFPNGQILEDHNCEI-VNKPPSVIQCHMHACPADVSWHQEPWTS 1428
Score = 85.5 bits (210), Expect = 2e-16
Identities = 64/234 (27%), Positives = 84/234 (35%), Gaps = 55/234 (23%)
Query: 659 TPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPC 718
T L A W+ + CS SCG+G C R++ + + + S A PA C
Sbjct: 1147 TVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC--RDALDRIADESYCAHLPRPAEIWDC 1204
Query: 719 HGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSC 778
TPC W+AG+W+ CS SCG G RQ+ C + C RP + Q C
Sbjct: 1205 F-TPCGE-WQAGDWSPCSASCGHGKTTRQVLCMNYH----QPIDENYCDPEVRPLMEQEC 1258
Query: 779 QLRLC------------------------------------------GHWEVGSPWSQCS 796
L C W G PW CS
Sbjct: 1259 SLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTG-PWGSCS 1317
Query: 797 VRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDW 850
C G + R V C NG S + AS +PP + C GPC W + +W
Sbjct: 1318 SSCSGGLQHRAVVCQDENGQSASYCDAAS---KPPELQQCGPGPC-PQWNYGNW 1367
Score = 77.4 bits (189), Expect = 5e-14
Identities = 49/155 (31%), Positives = 74/155 (47%), Gaps = 9/155 (5%)
Query: 668 WKRVGHSACSASCGKG-VWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPY 726
W + ++CSASCGKG +R +F CI + +L++ +C+ +PP + C CP
Sbjct: 1421 WHQEPWTSCSASCGKGRKYREVF-CIDQFQ-RKLEDTNCSQVQKPPTH-KACRSVRCPS- 1476
Query: 727 WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-GH 785
W+A W CS +CG G Q R + CR + G V E C RP + C + C H
Sbjct: 1477 WKANSWNECSVTCGSGVQQRDVYCRLK---GVGQVVEEMCDQSTRPCSQRRCWSQDCVQH 1533
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSE 820
+ CS C R +++ C N +V+E
Sbjct: 1534 KGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNE 1568
Score = 71.6 bits (174), Expect = 3e-12
Identities = 50/179 (27%), Positives = 78/179 (43%), Gaps = 9/179 (5%)
Query: 676 CSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSC 735
C+ C +G+ R CI + + ++ C P + C+ T C W + C
Sbjct: 859 CTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCN-TDCELRWHVIGKSEC 916
Query: 736 SRSCGPGTQHRQLQCRQEFGGGGSSVPPE--RCGHLPRPNITQSCQLR-LCGHWEVGSPW 792
S CG G + + C + G +V + CG +P + C + W S W
Sbjct: 917 SSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHY-SEW 975
Query: 793 SQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWS 851
SQCS CG G+RSR+ C+ N G +++ EC +RE C+ C +W S+WS
Sbjct: 976 SQCSRSCGGGERSRESYCMNNFGHRLADNECQE--LSRVTRENCNEFSC-PSWAASEWS 1031
Score = 66.2 bits (160), Expect = 1e-10
Identities = 41/127 (32%), Positives = 61/127 (48%), Gaps = 9/127 (7%)
Query: 730 GEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPN-ITQSCQLRLCGHWEV 788
G W C++ C G Q R + C + S V + C HLP P+ +TQSC W V
Sbjct: 854 GPWEGCTKMC-QGLQRRNITCIHK--SDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHV 910
Query: 789 GSPWSQCSVRCGRGQRSRQVRCVG---NNGDEVSEQECASGPP-QPPSREACDMGPCTTA 844
S+CS +CG+G R+ + C+ + G V + G +PP++E C T
Sbjct: 911 IGK-SECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTR 969
Query: 845 WFHSDWS 851
W +S+WS
Sbjct: 970 WHYSEWS 976
Score = 53.9 bits (128), Expect = 6e-07
Identities = 62/258 (24%), Positives = 92/258 (35%), Gaps = 73/258 (28%)
Query: 650 QMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGA 709
Q+ PP + WK + CS +CG GV + C + G+ ++E C
Sbjct: 1459 QVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEM-CDQST 1517
Query: 710 RPPASPEPCHGTPCPPY--WEAGEWTSCSRSCGPGTQHRQLQCRQ-------EFGGGGSS 760
RP S C C + E G +CS SC H++++C E S+
Sbjct: 1518 RP-CSQRRCWSQDCVQHKGMERGR-LNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSST 1575
Query: 761 V---------PP--------------ERCG---------------------HLPRPNITQ 776
+ PP CG H RP + Q
Sbjct: 1576 ISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQ 1635
Query: 777 SCQ----------LRLCGH---WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQEC 823
C + C H W+VG WS+CSV CG G RQV+C+ +G +S C
Sbjct: 1636 ECPVVPSSQVYQCINSCLHLATWKVGK-WSKCSVTCGIGIMKRQVKCITKHG--LSSDLC 1692
Query: 824 ASGPPQPPSREACDMGPC 841
+ +P +++ C C
Sbjct: 1693 LN-HLKPGAQKKCYANDC 1709
Score = 41.6 bits (96), Expect = 0.003
Identities = 14/30 (46%), Positives = 20/30 (66%)
Query: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
G WGPW ++SCS+ CG G++ +R C P
Sbjct: 557 GEWGPWEPYSSCSRTCGGGIESATRRCNRP 586
Score = 35.8 bits (81), Expect = 0.18
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 40 GQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQL 78
G GP W + W CSQ CG G++ R CQ P Q+
Sbjct: 1355 GPGPCPQWN-YGNWGECSQTCGGGIKSRLVICQFPNGQI 1392
Score = 34.3 bits (77), Expect = 0.52
Identities = 30/99 (30%), Positives = 35/99 (35%), Gaps = 13/99 (13%)
Query: 7 RPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQR 66
+P YL L L Q D E H + GP W SCS C G+Q
Sbjct: 1276 QPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGP---------WGSCSSSCSGGLQH 1326
Query: 67 RSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQ 105
R+ CQ Q +PP L G GP PQ
Sbjct: 1327 RAVVCQDENGQSASYCDAASKPPE----LQQCGPGPCPQ 1361
Score = 30.4 bits (67), Expect = 7.5
Identities = 15/41 (36%), Positives = 22/41 (53%), Gaps = 2/41 (4%)
Query: 31 HSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71
+S P EE + W P+ W C++ C G+QRR+ TC
Sbjct: 835 YSFNIPLEE-RSDMFTWDPYGPWEGCTKMC-QGLQRRNITC 873
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 190 bits (483), Expect = 4e-48
Identities = 142/439 (32%), Positives = 196/439 (44%), Gaps = 62/439 (14%)
Query: 364 CSGESEQLRACSQAPCPPEQPDP--RALQCAAFN----SQEFMGQLYQWEP-FTEVQGSQ 416
C G + R+C+ PCP R QC AFN S + W P ++ V
Sbjct: 555 CEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRD 614
Query: 417 RCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGV 476
+C+L CR G ++ KV DGTLC P + +CV G+C+ GCDG LGS +R D CGV
Sbjct: 615 KCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGV 674
Query: 477 CGGDDSTCRLVSGNLTDRGGPL-GYQKILWIPAGALRLQIAQ-----LRPSSNYLALRGP 530
CGGD+ +C+ V+G T P+ GY ++ IPAGA + I Q L NYLAL+
Sbjct: 675 CGGDNKSCKKVTGLFTK---PMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNS 731
Query: 531 GGRSIINGNWAVDP-PGSYRAGGTVFRYNRPPREEGKG---ESLSAEGPTTQP--VDVYM 584
G+ ++NG++ V G++ RY+ G G ESL A P +P V+V
Sbjct: 732 QGKYLLNGHFVVSAVERDLVVKGSLLRYS------GTGTAVESLQASRPILEPLTVEVLS 785
Query: 585 IFQEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQR 644
+ + P V Y + + P ++ P+ P R P L
Sbjct: 786 VGKMTPPRVRYSFYLPKEPREDKSSHPKDP----------------------RGPSVLHN 823
Query: 645 QVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERS 704
V + P P A W CSASCG G+ + C R S + +
Sbjct: 824 SV----LSLSNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDC--RGSAGQRTVPA 877
Query: 705 CAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPE 764
C A R P + C G PCP WE W+ CS+SCG G Q R L+C G GG + +
Sbjct: 878 CDAAHR-PVETQAC-GEPCPT-WELSAWSPCSKSCGRGFQRRSLKC---VGHGGRLLARD 931
Query: 765 RCGHLPRPNITQSCQLRLC 783
+C +P C LR C
Sbjct: 932 QCNLHRKPQELDFCVLRPC 950
Score = 37.7 bits (86), Expect = 0.047
Identities = 19/56 (33%), Positives = 25/56 (44%), Gaps = 5/56 (8%)
Query: 20 QLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPT 75
+LCL + H+L +G W W + CS+ CG GVQ R C PT
Sbjct: 497 KLCLKGACVERHNLNKHRVDGS-----WAKWDPYGPCSRTCGGGVQLARRQCTNPT 547
Score = 30.0 bits (66), Expect = 9.8
Identities = 11/19 (57%), Positives = 13/19 (68%)
Query: 53 WASCSQPCGVGVQRRSRTC 71
W+ CS+ CG G QRRS C
Sbjct: 902 WSPCSKSCGRGFQRRSLKC 920
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 178 bits (452), Expect = 2e-44
Identities = 146/489 (29%), Positives = 197/489 (40%), Gaps = 74/489 (15%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQ-EFMGQLYQWEPFTEVQGSQRCELNC 422
C G + + + C+ C D RA QC NS E+ + W P+ +RC L C
Sbjct: 590 CPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYC 649
Query: 423 RPRGFRFYVRHTEKVQDGTLCQPGAP-DICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
+ + + V DGT C P ICV G C+ GCD +GS + D CGVCGGD+
Sbjct: 650 QSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDN 709
Query: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG-GRSIINGNW 540
S CR V G T LGY K+ IP GA + I + S + LA++ G I+NG
Sbjct: 710 SHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKG 769
Query: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEEN--PGVFYQYV 598
++ G + YN E ESL +GP PV V +I QE + + Y+Y+
Sbjct: 770 EEAKSRTFIDLGVEWDYN----IEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYI 825
Query: 599 I--SSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPH 656
I S P I N +Q E+ E
Sbjct: 826 IHEDSVPTINSNNV-------IQEELDTFE------------------------------ 848
Query: 657 PRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPE 716
W S CS CG G + C + + + C A +P
Sbjct: 849 -----------WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRR 897
Query: 717 PCHGTPCP-PYWEAGEWTSCSRSCG-PGTQHRQLQCRQE-FGGGGSSVPPERCGHLPRPN 773
C+ C P W A EW C+++CG G Q R ++C Q G SV + C RP
Sbjct: 898 MCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPE 956
Query: 774 ITQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPS 832
+ C C W+ G PWS+CSV CG G RQV C GD + +P S
Sbjct: 957 SRRPCNRVPCPAQWKTG-PWSECSVTCGEGTEVRQVLC--RAGDHCDGE-------KPES 1006
Query: 833 REACDMGPC 841
AC + PC
Sbjct: 1007 VRACQLPPC 1015
Score = 60.8 bits (146), Expect = 5e-09
Identities = 41/134 (30%), Positives = 57/134 (42%), Gaps = 15/134 (11%)
Query: 727 WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPN-ITQSCQLRLCGH 785
W W+ CS+ CG G Q+ + CR++ V C +P I + C ++ C H
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRK--SDNKMVHRSFCEANKKPKPIRRMCNIQECTH 906
Query: 786 --WEVGSPWSQCSVRCGR-GQRSRQVRCV-----GNNGDEVSEQECASGPPQPPSREACD 837
W V W C+ CG G + R VRC+ G N V + C P+ SR C+
Sbjct: 907 PLW-VAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRS-VHSKYCMGDRPE--SRRPCN 962
Query: 838 MGPCTTAWFHSDWS 851
PC W WS
Sbjct: 963 RVPCPAQWKTGPWS 976
Score = 42.7 bits (99), Expect = 0.001
Identities = 16/34 (47%), Positives = 22/34 (64%)
Query: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
Q +G WG W ++ SCS+ CG GV+ R+R C P
Sbjct: 548 QKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNP 581
Score = 35.0 bits (79), Expect = 0.30
Identities = 38/138 (27%), Positives = 51/138 (36%), Gaps = 36/138 (26%)
Query: 649 PQMPAPPHPRTPLGSPAAYWKRVGHSACSA-----SCGKGVW-----RPIFLCISRESGE 698
P++P P + + VG+ C+A C K +W P F + G
Sbjct: 466 PKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPC-KQLWCSHPDNPYFC--KTKKGP 522
Query: 699 ELDERSCAAGARPPASPEPCHGTPCPPYWEA----------GEWT---SCSRSCGPGTQH 745
LD CAAG + C+ C W+ G WT SCSR+CG G +
Sbjct: 523 PLDGTECAAG-------KWCYKGHC--MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRF 573
Query: 746 RQLQCRQEFG-GGGSSVP 762
R QC GG P
Sbjct: 574 RTRQCNNPMPINGGQDCP 591
Score = 34.7 bits (78), Expect = 0.40
Identities = 19/55 (34%), Positives = 25/55 (45%)
Query: 666 AYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
A WK S CS +CG+G LC + + + S A PP + EPC G
Sbjct: 968 AQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLG 1022
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 176 bits (446), Expect = 8e-44
Identities = 129/446 (28%), Positives = 193/446 (43%), Gaps = 56/446 (12%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
C+GE ++ R C+ PC E P R +QC+ F++ + +LY W P + CEL CR
Sbjct: 581 CTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWFPI--FNPAHPCELYCR 638
Query: 424 PRGFRFYVRHTEKVQDGTLCQPG--APDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
P +F + + V DGT C G + ++C+ G C GCD + S D CGVC GD
Sbjct: 639 PIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDG 698
Query: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG-GRSIINGNW 540
S+C+ V + G GY I IP GA +++ ++ + N+LA+R + +NG +
Sbjct: 699 SSCQTVRKMFKQKEGS-GYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGF 757
Query: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
+ G+Y+ GTVF+Y+R +G E L A GPT + V + ++FQ NPG+ Y+Y I
Sbjct: 758 IIQWNGNYKLAGTVFQYDR----KGDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQ 813
Query: 601 SPPPILENPTPE------------------PPVPQLQPEILRVEPPLAPAP--RPARTPG 640
L+N + + + ++ + A P P
Sbjct: 814 KDG--LDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPN 871
Query: 641 TLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCG-KGVWRPIFLCISRESGEE 699
RQ + + PP W ACSA+CG G + LCI +E
Sbjct: 872 --GRQKKCHEKACPPR-----------WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDE 918
Query: 700 --LDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGG 757
L C +P CP W G W+ CS SCG G + R + C +
Sbjct: 919 QALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNH--- 975
Query: 758 GSSVPPERCGHLPRPNITQSCQLRLC 783
E C +PN C L+ C
Sbjct: 976 -----DEPCDVTRKPNSRALCGLQQC 996
Score = 110 bits (274), Expect = 7e-24
Identities = 65/182 (35%), Positives = 88/182 (48%), Gaps = 12/182 (6%)
Query: 667 YWKRVGH-SACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPP 725
Y+ + GH + CS +CG G+ R CI + G + C +P + CH CPP
Sbjct: 826 YFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGM-VKATFCDPETQPNGRQKKCHEKACPP 884
Query: 726 YWEAGEWTSCSRSCGP-GTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLR-LC 783
W AGEW +CS +CGP G + R + C Q ++PP C HL +P SC LC
Sbjct: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILC 944
Query: 784 -GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCT 842
W VG+ WS+CSV CG G R R V C N+ E +P SR C + C
Sbjct: 945 PSDWTVGN-WSECSVSCGGGVRIRSVTCAKNH------DEPCDVTRKPNSRALCGLQQCP 997
Query: 843 TA 844
++
Sbjct: 998 SS 999
Score = 102 bits (255), Expect = 1e-21
Identities = 62/186 (33%), Positives = 78/186 (41%), Gaps = 26/186 (13%)
Query: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCA--AGARPPAS----PEP 717
P A WK S CS +C G C+ L C AG PP S PEP
Sbjct: 1364 PCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEP 1423
Query: 718 CHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQS 777
C W+ W+ CSRSCG G Q R + C P C RP T S
Sbjct: 1424 CEA------WQVEPWSQCSRSCGGGVQERGVFC-----------PGGLCDWTKRPTSTMS 1466
Query: 778 CQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQE--CASGPPQPPSREA 835
C LC HW G+ W CS CG G + R V+CV + G++ +Q+ P+PP +
Sbjct: 1467 CNEHLCCHWATGN-WDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKK 1525
Query: 836 CDMGPC 841
C+ C
Sbjct: 1526 CNQQAC 1531
Score = 57.4 bits (137), Expect = 6e-08
Identities = 41/130 (31%), Positives = 49/130 (37%), Gaps = 11/130 (8%)
Query: 654 PPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPA 713
PP + P W+ S CS SCG GV +E G C RP
Sbjct: 1413 PPLSMSCNPEPCEAWQVEPWSQCSRSCGGGV---------QERGVFCPGGLCDWTKRP-T 1462
Query: 714 SPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPN 773
S C+ C +W G W CS SCG G Q R +QC G C H PRP
Sbjct: 1463 STMSCNEHLCC-HWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPP 1521
Query: 774 ITQSCQLRLC 783
+ C + C
Sbjct: 1522 EFKKCNQQAC 1531
Score = 42.4 bits (98), Expect = 0.002
Identities = 17/38 (44%), Positives = 21/38 (55%), Gaps = 3/38 (7%)
Query: 40 GQGPEGV---WGPWVQWASCSQPCGVGVQRRSRTCQLP 74
G+ PE + WG W W+ CS+ CG GVQ R C P
Sbjct: 535 GKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNP 572
Score = 39.3 bits (90), Expect = 0.016
Identities = 17/67 (25%), Positives = 27/67 (40%), Gaps = 1/67 (1%)
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAW 845
W+ G W++CSV CG G R + C+ V C ++ C C W
Sbjct: 828 WQYGH-WTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRW 886
Query: 846 FHSDWSS 852
+ +W +
Sbjct: 887 WAGEWEA 893
Score = 33.1 bits (74), Expect = 1.2
Identities = 19/58 (32%), Positives = 27/58 (46%), Gaps = 4/58 (6%)
Query: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC 841
G W SPWS CS CG G +S + C NN + + +G + C++ PC
Sbjct: 543 GGWGRWSPWSHCSRTCGAGVQSAERLC--NNPEPKFGGKYCTG--ERKRYRLCNVHPC 596
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 169 bits (429), Expect = 8e-42
Identities = 132/486 (27%), Positives = 188/486 (38%), Gaps = 63/486 (12%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEF-MGQLYQWEPFTEVQGSQRCELNC 422
C G + + C+ CP D RA QCA NS + W P+ +Q+CEL C
Sbjct: 591 CLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELIC 650
Query: 423 RPRGFRFYVRHTEKVQDGTLCQPGAP-DICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
+ V + V DGT C P +C G C+ GCD +GS + D CGVCGGD+
Sbjct: 651 QSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDN 710
Query: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWA 541
S CR V G L G K++ IPAGA +QI L S + + ++ + G++
Sbjct: 711 SHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQ-----VTGSFI 765
Query: 542 VDPPGSYRAGGTVFRYNRPPRE--EGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVI 599
++P G T + E ESL GP + + + +
Sbjct: 766 LNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILAL-------------- 811
Query: 600 SSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRT 659
PP PR + + + +P + +
Sbjct: 812 ---------------------------PPTEGGPRSSLAYKYVIHEDLLPLIGSN---NV 841
Query: 660 PLGSPAAY-WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPC 718
L Y W + CS +CG G+ + C R + C RP C
Sbjct: 842 LLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRC 901
Query: 719 HGTPCP-PYWEAGEWTSCSRSCGP-GTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQ 776
+ PC P W EW +CSRSCG G Q R +QC G V P + RP +
Sbjct: 902 NQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARR 961
Query: 777 SCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREA 835
C C W +G+ WSQCS CG G + RQV C N + + E +P + +
Sbjct: 962 PCLRVPCPAQWRLGA-WSQCSATCGEGIQQRQVVC-RTNANSLGHCE----GDRPDTVQV 1015
Query: 836 CDMGPC 841
C + C
Sbjct: 1016 CSLPAC 1021
Score = 58.5 bits (140), Expect = 3e-08
Identities = 39/132 (29%), Positives = 55/132 (41%), Gaps = 11/132 (8%)
Query: 727 WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPN-ITQSCQLRLCGH 785
W W CS++CG G Q + CR+ V C H RP I + C C
Sbjct: 851 WALKSWAPCSKACGGGIQFTKYGCRRR--RDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQ 908
Query: 786 --WEVGSPWSQCSVRCGR-GQRSRQVRCV---GNNGDEVSEQECASGPPQPPSREACDMG 839
W V W CS CG+ G ++R ++C+ N +V + +G +P +R C
Sbjct: 909 PVW-VTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGD-RPEARRPCLRV 966
Query: 840 PCTTAWFHSDWS 851
PC W WS
Sbjct: 967 PCPAQWRLGAWS 978
Score = 49.3 bits (116), Expect = 2e-05
Identities = 22/57 (38%), Positives = 31/57 (54%)
Query: 30 GHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPP 86
GH + E+ G +G W W ++ SCS+ CG GV+ RSR+C P+ L L P
Sbjct: 538 GHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGP 594
Score = 36.2 bits (82), Expect = 0.14
Identities = 83/344 (24%), Positives = 116/344 (33%), Gaps = 84/344 (24%)
Query: 50 WV--QWASCSQPCG-VGVQRRSRTCQLPTVQ-LHPSLPLPPRPPRHPEALLPRGQGPRPQ 105
WV +W +CS+ CG +GVQ R C LP H +P PEA P + P P
Sbjct: 911 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 970
Query: 106 TSPETLPLYRTQSRGRG-----GPLRGPASHLG-----REETQEI---RAARRSRLRDPI 152
+ + G G R A+ LG R +T ++ A + +
Sbjct: 971 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTV 1030
Query: 153 KPGMFGYGR-----VPFALPLHRNR----------------------RHPRSPPRSELSL 185
+ ++ G VP + PLH R+ P L
Sbjct: 1031 RADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCC 1090
Query: 186 ISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTP-SPQAEPLSPETAQTEVAPRT 244
+S + + P+P P P T LPP TP SP P P A P
Sbjct: 1091 VSCIKKASGPNPGPDPGP--------TSLPP----FSTPGSPLPGPQDPADA---AEPPG 1135
Query: 245 RPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRP----- 299
+P H +A T+ P + G +P+ P + SP G P
Sbjct: 1136 KPTGSEDHQHGRA--TQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQ 1193
Query: 300 DPFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLS 343
P P VP +GQ G+ D +HPG LP S
Sbjct: 1194 TPTP-VPEDKGQPGE----------------DLRHPGTSLPAAS 1220
Score = 33.9 bits (76), Expect = 0.68
Identities = 52/201 (25%), Positives = 69/201 (34%), Gaps = 38/201 (18%)
Query: 43 PEGVWGPW------VQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALL 96
PEG W P + S ++PC RS CQ+ + + S+P R
Sbjct: 1040 PEGQWVPQSEPLHPINKISSTEPC---TGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIKK 1096
Query: 97 PRGQGPRPQTSPETLPLYRTQSRGRGGP------LRGPASHLGREETQEIRAARRSRLRD 150
G P P P +LP + T GP P G E+ Q RA + D
Sbjct: 1097 ASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALD 1156
Query: 151 PIKPGMFGYGRVPFALPLHRNRRHPRSPPRSELSLISSRGEEAIP-----SPTPRAEPFS 205
PG + PFA P +P IS +P +PTP E
Sbjct: 1157 TSSPGT----QHPFA---------PETPIPGASWSISPTTPGGLPWGWTQTPTPVPED-- 1201
Query: 206 ANGSPQTEL--PPTELSVHTP 224
G P +L P T L +P
Sbjct: 1202 -KGQPGEDLRHPGTSLPAASP 1221
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 169 bits (429), Expect = 8e-42
Identities = 132/486 (27%), Positives = 188/486 (38%), Gaps = 63/486 (12%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEF-MGQLYQWEPFTEVQGSQRCELNC 422
C G + + C+ CP D RA QCA NS + W P+ +Q+CEL C
Sbjct: 594 CLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELIC 653
Query: 423 RPRGFRFYVRHTEKVQDGTLCQPGAP-DICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
+ V + V DGT C P +C G C+ GCD +GS + D CGVCGGD+
Sbjct: 654 QSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDN 713
Query: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWA 541
S CR V G L G K++ IPAGA +QI L S + + ++ + G++
Sbjct: 714 SHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQ-----VTGSFI 768
Query: 542 VDPPGSYRAGGTVFRYNRPPRE--EGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVI 599
++P G T + E ESL GP + + + +
Sbjct: 769 LNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILAL-------------- 814
Query: 600 SSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRT 659
PP PR + + + +P + +
Sbjct: 815 ---------------------------PPTEGGPRSSLAYKYVIHEDLLPLIGSN---NV 844
Query: 660 PLGSPAAY-WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPC 718
L Y W + CS +CG G+ + C R + C RP C
Sbjct: 845 LLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRC 904
Query: 719 HGTPCP-PYWEAGEWTSCSRSCGP-GTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQ 776
+ PC P W EW +CSRSCG G Q R +QC G V P + RP +
Sbjct: 905 NQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARR 964
Query: 777 SCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREA 835
C C W +G+ WSQCS CG G + RQV C N + + E +P + +
Sbjct: 965 PCLRVPCPAQWRLGA-WSQCSATCGEGIQQRQVVC-RTNANSLGHCE----GDRPDTVQV 1018
Query: 836 CDMGPC 841
C + C
Sbjct: 1019 CSLPAC 1024
Score = 58.5 bits (140), Expect = 3e-08
Identities = 39/132 (29%), Positives = 55/132 (41%), Gaps = 11/132 (8%)
Query: 727 WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPN-ITQSCQLRLCGH 785
W W CS++CG G Q + CR+ V C H RP I + C C
Sbjct: 854 WALKSWAPCSKACGGGIQFTKYGCRRR--RDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQ 911
Query: 786 --WEVGSPWSQCSVRCGR-GQRSRQVRCV---GNNGDEVSEQECASGPPQPPSREACDMG 839
W V W CS CG+ G ++R ++C+ N +V + +G +P +R C
Sbjct: 912 PVW-VTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGD-RPEARRPCLRV 969
Query: 840 PCTTAWFHSDWS 851
PC W WS
Sbjct: 970 PCPAQWRLGAWS 981
Score = 49.3 bits (116), Expect = 2e-05
Identities = 22/57 (38%), Positives = 31/57 (54%)
Query: 30 GHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPP 86
GH + E+ G +G W W ++ SCS+ CG GV+ RSR+C P+ L L P
Sbjct: 541 GHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGP 597
Score = 36.2 bits (82), Expect = 0.14
Identities = 83/344 (24%), Positives = 116/344 (33%), Gaps = 84/344 (24%)
Query: 50 WV--QWASCSQPCG-VGVQRRSRTCQLPTVQ-LHPSLPLPPRPPRHPEALLPRGQGPRPQ 105
WV +W +CS+ CG +GVQ R C LP H +P PEA P + P P
Sbjct: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 973
Query: 106 TSPETLPLYRTQSRGRG-----GPLRGPASHLG-----REETQEI---RAARRSRLRDPI 152
+ + G G R A+ LG R +T ++ A + +
Sbjct: 974 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTV 1033
Query: 153 KPGMFGYGR-----VPFALPLHRNR----------------------RHPRSPPRSELSL 185
+ ++ G VP + PLH R+ P L
Sbjct: 1034 RADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCC 1093
Query: 186 ISSRGEEAIPSPTPRAEPFSANGSPQTELPPTELSVHTP-SPQAEPLSPETAQTEVAPRT 244
+S + + P+P P P T LPP TP SP P P A P
Sbjct: 1094 VSCIKKASGPNPGPDPGP--------TSLPP----FSTPGSPLPGPQDPADA---AEPPG 1138
Query: 245 RPAPLRHHPRAQASGTEPPSPTHSLGEGGFFRASPQPRRPSSQGWASPQVAGRRP----- 299
+P H +A T+ P + G +P+ P + SP G P
Sbjct: 1139 KPTGSEDHQHGRA--TQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQ 1196
Query: 300 DPFPSVPRGRGQQGQGPWGTGGTPHGPRLEPDPQHPGAWLPLLS 343
P P VP +GQ G+ D +HPG LP S
Sbjct: 1197 TPTP-VPEDKGQPGE----------------DLRHPGTSLPAAS 1223
Score = 33.9 bits (76), Expect = 0.68
Identities = 52/201 (25%), Positives = 69/201 (34%), Gaps = 38/201 (18%)
Query: 43 PEGVWGPW------VQWASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRHPEALL 96
PEG W P + S ++PC RS CQ+ + + S+P R
Sbjct: 1043 PEGQWVPQSEPLHPINKISSTEPC---TGDRSVFCQMEVLDRYCSIPGYHRLCCVSCIKK 1099
Query: 97 PRGQGPRPQTSPETLPLYRTQSRGRGGP------LRGPASHLGREETQEIRAARRSRLRD 150
G P P P +LP + T GP P G E+ Q RA + D
Sbjct: 1100 ASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALD 1159
Query: 151 PIKPGMFGYGRVPFALPLHRNRRHPRSPPRSELSLISSRGEEAIP-----SPTPRAEPFS 205
PG + PFA P +P IS +P +PTP E
Sbjct: 1160 TSSPGT----QHPFA---------PETPIPGASWSISPTTPGGLPWGWTQTPTPVPED-- 1204
Query: 206 ANGSPQTEL--PPTELSVHTP 224
G P +L P T L +P
Sbjct: 1205 -KGQPGEDLRHPGTSLPAASP 1224
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 167 bits (422), Expect = 5e-41
Identities = 145/546 (26%), Positives = 218/546 (39%), Gaps = 94/546 (17%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
C G + + R CS CPPE D RA QC+A N + GQ Y+W P + C L C+
Sbjct: 66 CEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSN-DPDNPCSLKCQ 124
Query: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
+G V KV DGT C + D+C++G C GCD LGS + D CGVC GD ST
Sbjct: 125 AKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGST 184
Query: 484 CRLVSGNLTDR-GGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAV 542
CRLV G + ++ IP G+ +++ P YL + G G ++
Sbjct: 185 CRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQG---TKGENSL 241
Query: 543 DPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPG--------VF 594
G++ + + + P + E L GP T I + N G +F
Sbjct: 242 SSTGTFLVDNSSVDFQKFPDK----EILRMAGPLTAD----FIVKIRNSGSADSTVQFIF 293
Query: 595 YQYVI-----------------------SSPPPILENPTPEPPVPQLQPEILRVEPPLAP 631
YQ +I + + N PE ++ +P L
Sbjct: 294 YQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE 353
Query: 632 APRPARTPGTLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLC 691
+Q+ +P P PR W+ +ACS+SCG G+ C
Sbjct: 354 CNLDPCPASDGYKQI-MPYDLYHPLPR---------WEATPWTACSSSCGGGIQSRAVSC 403
Query: 692 ISRE---SGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQL 748
+ + ++E C + P + +PC+ CP W A EW+ C+ +CG G ++R +
Sbjct: 404 VEEDIQGHVTSVEEWKCMYTPKMPIA-QPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVV 461
Query: 749 QCRQEFG--GGGSS-----------VPPERCGHLPRPNITQSCQL---RLCGHWEVGS-- 790
C G GG S + P C + P+ + +L + E G+
Sbjct: 462 LCIDHRGMHTGGCSPKTKPHIKEECIVPTPC-YKPKEKLPVEAKLPWFKQAQELEEGAAV 520
Query: 791 ---------PWSQCSVRCGRGQRSRQVRC-----VGNNGDEVSEQECASGPPQPPSREAC 836
WS C+V CG G + R VRC + ++ EC P+P S+ AC
Sbjct: 521 SEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEG--PKPASQRAC 578
Query: 837 DMGPCT 842
GPC+
Sbjct: 579 YAGPCS 584
Score = 115 bits (288), Expect = 2e-25
Identities = 58/190 (30%), Positives = 90/190 (47%), Gaps = 8/190 (4%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
W+ G + CS SCG GV + C+++++ E +E C RPP + C+ PCP W
Sbjct: 611 WEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARW 670
Query: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGG--GGSSVPPERCGHLPRPNITQSCQLRLCGH 785
E G+W+ CS +CG G Q R + C + + + P+P+ Q+C C
Sbjct: 671 EIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPP 730
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGD----EVSEQECASGPPQPPSREACDMGPC 841
+ W CS CG G + R+V C D E+ E C++ +P ++AC C
Sbjct: 731 AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSAS--KPACQQACKKDDC 788
Query: 842 TTAWFHSDWS 851
+ W SDW+
Sbjct: 789 PSEWLLSDWT 798
Score = 105 bits (262), Expect = 2e-22
Identities = 65/192 (33%), Positives = 95/192 (49%), Gaps = 11/192 (5%)
Query: 667 YWKRVGHSA-CSASCG-KGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCP 724
YW V A CSASCG +GV +P C+ + E++ CA RP P C+ CP
Sbjct: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCLLNST--EVNPAHCAGKVRPAVQPIACNRRDCP 1546
Query: 725 PYWEAGEWTSCSRSCGPGTQHRQLQCRQ-EFGGGGSSVPPERCGHL-PRPNITQSCQLRL 782
W W++C+RSCG G Q R++ C++ + G + V + C + RP TQ+C +L
Sbjct: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
Query: 783 CGHWEVGSPWSQCSVRC---GRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMG 839
C W S W QC+ C + RQV C +G + ++C S P+P S + C
Sbjct: 1607 CVEWAFSS-WGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQC-SALPRPVSTQNCWSE 1664
Query: 840 PCTTAWFHSDWS 851
C+ W S W+
Sbjct: 1665 ACSVHWRVSLWT 1676
Score = 92.8 bits (229), Expect = 1e-18
Identities = 58/182 (31%), Positives = 84/182 (46%), Gaps = 13/182 (7%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESG---EELDERSCAAGARPPASPEPCHGTPCP 724
W SAC+ SCG GV C ++ + C A+ P + C+ C
Sbjct: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
Query: 725 PYWEAGEWTSCSRSC-GP--GTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLR 781
W W C+ C GP QHRQ+ C+ G ++P E+C LPRP TQ+C
Sbjct: 1609 E-WAFSSWGQCNGPCIGPHLAVQHRQVFCQTR---DGITLPSEQCSALPRPVSTQNCWSE 1664
Query: 782 LCG-HWEVGSPWSQCSVRCGR-GQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMG 839
C HW V S W+ C+ CG G +SR+V CV ++ + S P+P + + C++
Sbjct: 1665 ACSVHWRV-SLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNIT 1723
Query: 840 PC 841
PC
Sbjct: 1724 PC 1725
Score = 87.4 bits (215), Expect = 5e-17
Identities = 46/148 (31%), Positives = 68/148 (45%), Gaps = 3/148 (2%)
Query: 666 AYWKRVGHSACSASCGKGVWRPIFLC---ISRESGEELDERSCAAGARPPASPEPCHGTP 722
A W+ S CS +CG G+ C +SRE E + P++ + C+
Sbjct: 668 ARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFN 727
Query: 723 CPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRL 782
CPP W +W CSR+CG G Q R++ C+Q G PE +P Q+C+
Sbjct: 728 CPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDD 787
Query: 783 CGHWEVGSPWSQCSVRCGRGQRSRQVRC 810
C + S W++CS CG G ++R C
Sbjct: 788 CPSEWLLSDWTECSTSCGEGTQTRSAIC 815
Score = 73.2 bits (178), Expect = 1e-12
Identities = 61/213 (28%), Positives = 86/213 (40%), Gaps = 43/213 (20%)
Query: 674 SACSASCGKGVWRPIFLC----ISRESGEELDERSCAAGARPPASPEPCHGTPC----PP 725
SAC+ +CG G I C +S +L C PAS C+ PC P
Sbjct: 532 SACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECE--GPKPASQRACYAGPCSGEIPE 589
Query: 726 Y--------------------WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPER 765
+ WE +T CS SCG G Q + C + + P E
Sbjct: 590 FNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNK----QTREPAEE 645
Query: 766 --CGHLPR-PNITQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQ 821
C R P + +SC L C WE+G WS CS+ CG G ++R V C E++E
Sbjct: 646 NLCVTSRRPPQLLKSCNLDPCPARWEIGK-WSPCSLTCGVGLQTRDVFCSHLLSREMNET 704
Query: 822 ECASG----PPQPPSREACDMGPCTTAWFHSDW 850
+ P+P + +AC+ C AW+ + W
Sbjct: 705 VILADELCRQPKPSTVQACNRFNCPPAWYPAQW 737
Score = 69.7 bits (169), Expect = 1e-11
Identities = 43/120 (35%), Positives = 53/120 (44%), Gaps = 6/120 (5%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGE---ELDERSCAAGARPPASPEPCHGTPCP 724
W CS +CG GV + LC R + EL E C+A PA + C CP
Sbjct: 732 WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASK--PACQQACKKDDCP 789
Query: 725 PYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPER-CGHLPRPNITQSCQLRLC 783
W +WT CS SCG GTQ R CR+ G S+V C LP + + C L C
Sbjct: 790 SEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATC 849
Score = 66.6 bits (161), Expect = 9e-11
Identities = 60/278 (21%), Positives = 102/278 (36%), Gaps = 74/278 (26%)
Query: 657 PRTPLGSPAAY-----WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARP 711
P+ P+ P W S C+ +CG+G+ + LCI + C+ +P
Sbjct: 424 PKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG---MHTGGCSPKTKP 480
Query: 712 PASPEPCHGTPC-------------PPYWEAGE-----------------WTSCSRSCGP 741
E TPC P + +A E W++C+ +CG
Sbjct: 481 HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGV 540
Query: 742 GTQHRQLQCR--QEFGGGGSSVPPERCGHLPRPNITQSCQLRLCG--------------- 784
GTQ R ++C+ F + +P + C P+P ++C C
Sbjct: 541 GTQVRIVRCQVLLSFSQSVADLPIDEC-EGPKPASQRACYAGPCSGEIPEFNPDETDGLF 599
Query: 785 ----------HWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQE-CASGPPQPPSR 833
WE +++CS CG G + V C+ E +E+ C + P
Sbjct: 600 GGLQDFDELYDWEY-EGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLL 658
Query: 834 EACDMGPCTTAWFHSDWSSKVSPEPPAISCILGNHAQD 871
++C++ PC W WS P +++C +G +D
Sbjct: 659 KSCNLDPCPARWEIGKWS------PCSLTCGVGLQTRD 690
Score = 50.8 bits (120), Expect = 5e-06
Identities = 34/111 (30%), Positives = 48/111 (43%), Gaps = 6/111 (5%)
Query: 686 RPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGP-GTQ 744
R +F C +R+ G L C+A RP S + C C +W WT C+ +CG G Q
Sbjct: 1632 RQVF-CQTRD-GITLPSEQCSALPRP-VSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQ 1688
Query: 745 HRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQC 795
R+++C +VP C PRP Q C + C + E C
Sbjct: 1689 SRRVECVH--ARTNKAVPEHLCSWGPRPANWQRCNITPCENMECRDTTRYC 1737
Score = 37.4 bits (85), Expect = 0.061
Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 2/80 (2%)
Query: 774 ITQSCQLRLCGHWEVGSPWSQCSVRCG-RGQRSRQVRCVGNNGDEVSEQECASGPPQPPS 832
+ Q L + +W + CS CG RG + ++RC+ N+ EV+ CA
Sbjct: 1478 LMQKASLVIQDYWWSVDRLATCSASCGNRGVQQPRLRCLLNS-TEVNPAHCAGKVRPAVQ 1536
Query: 833 REACDMGPCTTAWFHSDWSS 852
AC+ C + W + WS+
Sbjct: 1537 PIACNRRDCPSRWMVTSWSA 1556
Score = 33.9 bits (76), Expect = 0.68
Identities = 11/28 (39%), Positives = 15/28 (53%)
Query: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTC 71
+G+W W W+ CS+ CG G R C
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRC 60
Score = 33.5 bits (75), Expect = 0.89
Identities = 21/88 (23%), Positives = 36/88 (40%), Gaps = 15/88 (17%)
Query: 727 WEA-GEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-G 784
W+A G W+ CSR+CG G + +C G ++ C ++ P + + C
Sbjct: 36 WDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSA 95
Query: 785 HWEV-------------GSPWSQCSVRC 799
H +V P + CS++C
Sbjct: 96 HNDVKHHGQFYEWLPVSNDPDNPCSLKC 123
Score = 33.1 bits (74), Expect = 1.2
Identities = 13/34 (38%), Positives = 17/34 (50%)
Query: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDE 817
G W+ PWS+CS CG G RC+ + E
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCE 67
Score = 31.6 bits (70), Expect = 3.4
Identities = 13/26 (50%), Positives = 16/26 (61%), Gaps = 1/26 (3%)
Query: 47 WGPWVQWASCSQPCGVGVQRRSRTCQ 72
W P QW CS+ CG GVQ+R C+
Sbjct: 732 WYP-AQWQPCSRTCGGGVQKREVLCK 756
Score = 31.2 bits (69), Expect = 4.4
Identities = 11/20 (55%), Positives = 15/20 (75%)
Query: 53 WASCSQPCGVGVQRRSRTCQ 72
W++C++ CG GVQ R TCQ
Sbjct: 1554 WSACTRSCGGGVQTRRVTCQ 1573
Score = 30.4 bits (67), Expect = 7.5
Identities = 11/27 (40%), Positives = 16/27 (59%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLH 79
W +CS CG G+Q R+ +C +Q H
Sbjct: 385 WTACSSSCGGGIQSRAVSCVEEDIQGH 411
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 153 bits (387), Expect = 6e-37
Identities = 148/518 (28%), Positives = 202/518 (38%), Gaps = 82/518 (15%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQ-----LYQW-EPFTEVQGSQR 417
C G Q C+ C Q + + QCA + Q Y W QG
Sbjct: 392 CVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDAL 451
Query: 418 CELNCRPRGFRFYVRHTEKVQDGTLCQPGAP------DICVAGRCLSPGCDGILGSGRRP 471
C CR G F ++ + DGT C P P +CV+G C + GCDG + S +
Sbjct: 452 CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVW 511
Query: 472 DGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG 531
D C VCGGD+STC G+ T G Y L + + IA RP +LA+R
Sbjct: 512 DRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR--- 567
Query: 532 GRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENP 591
I G + V GK +S TT P + E+
Sbjct: 568 ----IGGRYVV---------------------AGK---MSISPNTTYPSLL------EDG 593
Query: 592 GVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAP------RPARTPGTLQRQ 645
V Y+ ++ E +P+L E +R+ PL R G L R
Sbjct: 594 RVEYRVALT-----------EDRLPRL--EEIRIWGPLQEDADIQVYRRYGEEYGNLTRP 640
Query: 646 VRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSC 705
I P PR A W V CS SCG G+ + C+ + E ++ C
Sbjct: 641 -DITFTYFQPKPRQ-----AWVWAAV-RGPCSVSCGAGLRWVNYSCLDQARKELVETVQC 693
Query: 706 AAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPER 765
+PPA PE C PCPPYW G++ CS SCG G + R ++C + G ++PP R
Sbjct: 694 QGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPAR 753
Query: 766 C-GHLPRPNIT-QSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCV-GNNGDEVSEQ 821
C +P + ++C + C WEV P S C+ G G CV G +G E
Sbjct: 754 CRAGAQQPAVALETCNPQPCPARWEVSEP-SSCTSAGGAGLALENETCVPGADGLEAPVT 812
Query: 822 E-CASGPPQPPSREACDMGPCTTAWFHSDWSSKVSPEP 858
E S + P+ E C C W H D +S P
Sbjct: 813 EGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAP 850
Score = 104 bits (259), Expect = 4e-22
Identities = 60/172 (34%), Positives = 78/172 (45%), Gaps = 5/172 (2%)
Query: 674 SACSASCGKGVWRPIFLCI---SRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAG 730
+ACS SCG+GV R I C + GEE+ + G P E C PCPP W+
Sbjct: 929 AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVM 988
Query: 731 EWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGH-WEVG 789
CS SCG GT R + C Q G V C L RP + C + C + W VG
Sbjct: 989 SLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVG 1048
Query: 790 SPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC 841
+ W +CSV CG G + R+ C+G + P+P + C GPC
Sbjct: 1049 T-WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
Score = 99.8 bits (247), Expect = 1e-20
Identities = 79/259 (30%), Positives = 108/259 (41%), Gaps = 17/259 (6%)
Query: 606 LENPTPEPPVPQLQPEILR----VEPPLAPAPRP----ARTPGTLQRQVRIPQMPAP-PH 656
LEN T P L+ + V+ L PAP P + PG AP P
Sbjct: 795 LENETCVPGADGLEAPVTEGPGSVDEKL-PAPEPCVGMSCPPGWGHLDATSAGEKAPSPW 853
Query: 657 PRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPE 716
G+ AA+ +CS SCG+G+ FLC+ + E C ++P + E
Sbjct: 854 GSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRRE 913
Query: 717 PCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFG--GGGSSVPPERCGHLPRPNI 774
C PCP W+ + +CS SCG G R L C + G G + +C LPRP
Sbjct: 914 VCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP 972
Query: 775 TQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECA-SGPPQPP 831
++C L C W+V S CS CG G R V CV + G +V E A + +P
Sbjct: 973 QEACSLEPCPPRWKVMS-LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1031
Query: 832 SREACDMGPCTTAWFHSDW 850
+ C + CT W W
Sbjct: 1032 ASVPCLIADCTYRWHVGTW 1050
Score = 37.0 bits (84), Expect = 0.080
Identities = 42/152 (27%), Positives = 52/152 (34%), Gaps = 45/152 (29%)
Query: 730 GEWTS------CSRSCGPGTQHRQLQC---RQEFGGG---GSSVPPERCGHLPRPNITQS 777
G W+S CSRSCG G R+ QC R FGG G+ + E C TQ+
Sbjct: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCN-------TQA 406
Query: 778 C---QLRLCG---------------------HWEVGSPWSQCSVRCGRGQRSRQVRCVGN 813
C QL HW P SQ C R+ +
Sbjct: 407 CEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMK 466
Query: 814 NGDE-VSEQEC-ASGPPQPPSREACDMGPCTT 843
GD + C SGP + + C G C T
Sbjct: 467 RGDSFLDGTRCMPSGPREDGTLSLCVSGSCRT 498
Score = 33.1 bits (74), Expect = 1.2
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 5/48 (10%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRH-PEALLPRG 99
W CS CG G+QRR TC P Q P+P +H P+ + RG
Sbjct: 1050 WMECSVSCGDGIQRRRDTCLGPQAQ----APVPADFCQHLPKPVTVRG 1093
Score = 31.6 bits (70), Expect = 3.4
Identities = 13/30 (43%), Positives = 15/30 (50%)
Query: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
G W W + CS+ CG GV R R C P
Sbjct: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNP 383
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 153 bits (387), Expect = 6e-37
Identities = 148/518 (28%), Positives = 202/518 (38%), Gaps = 82/518 (15%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQ-----LYQW-EPFTEVQGSQR 417
C G Q C+ C Q + + QCA + Q Y W QG
Sbjct: 423 CVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDAL 482
Query: 418 CELNCRPRGFRFYVRHTEKVQDGTLCQPGAP------DICVAGRCLSPGCDGILGSGRRP 471
C CR G F ++ + DGT C P P +CV+G C + GCDG + S +
Sbjct: 483 CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVW 542
Query: 472 DGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG 531
D C VCGGD+STC G+ T G Y L + + IA RP +LA+R
Sbjct: 543 DRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR--- 598
Query: 532 GRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENP 591
I G + V GK +S TT P + E+
Sbjct: 599 ----IGGRYVV---------------------AGK---MSISPNTTYPSLL------EDG 624
Query: 592 GVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAP------RPARTPGTLQRQ 645
V Y+ ++ E +P+L E +R+ PL R G L R
Sbjct: 625 RVEYRVALT-----------EDRLPRL--EEIRIWGPLQEDADIQVYRRYGEEYGNLTRP 671
Query: 646 VRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSC 705
I P PR A W V CS SCG G+ + C+ + E ++ C
Sbjct: 672 -DITFTYFQPKPRQ-----AWVWAAV-RGPCSVSCGAGLRWVNYSCLDQARKELVETVQC 724
Query: 706 AAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPER 765
+PPA PE C PCPPYW G++ CS SCG G + R ++C + G ++PP R
Sbjct: 725 QGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPAR 784
Query: 766 C-GHLPRPNIT-QSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCV-GNNGDEVSEQ 821
C +P + ++C + C WEV P S C+ G G CV G +G E
Sbjct: 785 CRAGAQQPAVALETCNPQPCPARWEVSEP-SSCTSAGGAGLALENETCVPGADGLEAPVT 843
Query: 822 E-CASGPPQPPSREACDMGPCTTAWFHSDWSSKVSPEP 858
E S + P+ E C C W H D +S P
Sbjct: 844 EGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAP 881
Score = 104 bits (259), Expect = 4e-22
Identities = 60/172 (34%), Positives = 78/172 (45%), Gaps = 5/172 (2%)
Query: 674 SACSASCGKGVWRPIFLCI---SRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAG 730
+ACS SCG+GV R I C + GEE+ + G P E C PCPP W+
Sbjct: 960 AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVM 1019
Query: 731 EWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGH-WEVG 789
CS SCG GT R + C Q G V C L RP + C + C + W VG
Sbjct: 1020 SLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVG 1079
Query: 790 SPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC 841
+ W +CSV CG G + R+ C+G + P+P + C GPC
Sbjct: 1080 T-WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 99.8 bits (247), Expect = 1e-20
Identities = 79/259 (30%), Positives = 108/259 (41%), Gaps = 17/259 (6%)
Query: 606 LENPTPEPPVPQLQPEILR----VEPPLAPAPRP----ARTPGTLQRQVRIPQMPAP-PH 656
LEN T P L+ + V+ L PAP P + PG AP P
Sbjct: 826 LENETCVPGADGLEAPVTEGPGSVDEKL-PAPEPCVGMSCPPGWGHLDATSAGEKAPSPW 884
Query: 657 PRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPE 716
G+ AA+ +CS SCG+G+ FLC+ + E C ++P + E
Sbjct: 885 GSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRRE 944
Query: 717 PCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFG--GGGSSVPPERCGHLPRPNI 774
C PCP W+ + +CS SCG G R L C + G G + +C LPRP
Sbjct: 945 VCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP 1003
Query: 775 TQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECA-SGPPQPP 831
++C L C W+V S CS CG G R V CV + G +V E A + +P
Sbjct: 1004 QEACSLEPCPPRWKVMS-LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1062
Query: 832 SREACDMGPCTTAWFHSDW 850
+ C + CT W W
Sbjct: 1063 ASVPCLIADCTYRWHVGTW 1081
Score = 37.0 bits (84), Expect = 0.080
Identities = 42/152 (27%), Positives = 52/152 (34%), Gaps = 45/152 (29%)
Query: 730 GEWTS------CSRSCGPGTQHRQLQC---RQEFGGG---GSSVPPERCGHLPRPNITQS 777
G W+S CSRSCG G R+ QC R FGG G+ + E C TQ+
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCN-------TQA 437
Query: 778 C---QLRLCG---------------------HWEVGSPWSQCSVRCGRGQRSRQVRCVGN 813
C QL HW P SQ C R+ +
Sbjct: 438 CEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMK 497
Query: 814 NGDE-VSEQEC-ASGPPQPPSREACDMGPCTT 843
GD + C SGP + + C G C T
Sbjct: 498 RGDSFLDGTRCMPSGPREDGTLSLCVSGSCRT 529
Score = 33.1 bits (74), Expect = 1.2
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 5/48 (10%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRH-PEALLPRG 99
W CS CG G+QRR TC P Q P+P +H P+ + RG
Sbjct: 1081 WMECSVSCGDGIQRRRDTCLGPQAQ----APVPADFCQHLPKPVTVRG 1124
Score = 31.6 bits (70), Expect = 3.4
Identities = 13/30 (43%), Positives = 15/30 (50%)
Query: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
G W W + CS+ CG GV R R C P
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNP 414
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 153 bits (387), Expect = 6e-37
Identities = 148/518 (28%), Positives = 202/518 (38%), Gaps = 82/518 (15%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQ-----LYQW-EPFTEVQGSQR 417
C G Q C+ C Q + + QCA + Q Y W QG
Sbjct: 423 CVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDAL 482
Query: 418 CELNCRPRGFRFYVRHTEKVQDGTLCQPGAP------DICVAGRCLSPGCDGILGSGRRP 471
C CR G F ++ + DGT C P P +CV+G C + GCDG + S +
Sbjct: 483 CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVW 542
Query: 472 DGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG 531
D C VCGGD+STC G+ T G Y L + + IA RP +LA+R
Sbjct: 543 DRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR--- 598
Query: 532 GRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENP 591
I G + V GK +S TT P + E+
Sbjct: 599 ----IGGRYVV---------------------AGK---MSISPNTTYPSLL------EDG 624
Query: 592 GVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAP------RPARTPGTLQRQ 645
V Y+ ++ E +P+L E +R+ PL R G L R
Sbjct: 625 RVEYRVALT-----------EDRLPRL--EEIRIWGPLQEDADIQVYRRYGEEYGNLTRP 671
Query: 646 VRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSC 705
I P PR A W V CS SCG G+ + C+ + E ++ C
Sbjct: 672 -DITFTYFQPKPRQ-----AWVWAAV-RGPCSVSCGAGLRWVNYSCLDQARKELVETVQC 724
Query: 706 AAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPER 765
+PPA PE C PCPPYW G++ CS SCG G + R ++C + G ++PP R
Sbjct: 725 QGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPAR 784
Query: 766 C-GHLPRPNIT-QSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCV-GNNGDEVSEQ 821
C +P + ++C + C WEV P S C+ G G CV G +G E
Sbjct: 785 CRAGAQQPAVALETCNPQPCPARWEVSEP-SSCTSAGGAGLALENETCVPGADGLEAPVT 843
Query: 822 E-CASGPPQPPSREACDMGPCTTAWFHSDWSSKVSPEP 858
E S + P+ E C C W H D +S P
Sbjct: 844 EGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAP 881
Score = 104 bits (259), Expect = 4e-22
Identities = 60/172 (34%), Positives = 78/172 (45%), Gaps = 5/172 (2%)
Query: 674 SACSASCGKGVWRPIFLCI---SRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAG 730
+ACS SCG+GV R I C + GEE+ + G P E C PCPP W+
Sbjct: 960 AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVM 1019
Query: 731 EWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGH-WEVG 789
CS SCG GT R + C Q G V C L RP + C + C + W VG
Sbjct: 1020 SLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVG 1079
Query: 790 SPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC 841
+ W +CSV CG G + R+ C+G + P+P + C GPC
Sbjct: 1080 T-WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 99.8 bits (247), Expect = 1e-20
Identities = 79/259 (30%), Positives = 108/259 (41%), Gaps = 17/259 (6%)
Query: 606 LENPTPEPPVPQLQPEILR----VEPPLAPAPRP----ARTPGTLQRQVRIPQMPAP-PH 656
LEN T P L+ + V+ L PAP P + PG AP P
Sbjct: 826 LENETCVPGADGLEAPVTEGPGSVDEKL-PAPEPCVGMSCPPGWGHLDATSAGEKAPSPW 884
Query: 657 PRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPE 716
G+ AA+ +CS SCG+G+ FLC+ + E C ++P + E
Sbjct: 885 GSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRRE 944
Query: 717 PCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFG--GGGSSVPPERCGHLPRPNI 774
C PCP W+ + +CS SCG G R L C + G G + +C LPRP
Sbjct: 945 VCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP 1003
Query: 775 TQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECA-SGPPQPP 831
++C L C W+V S CS CG G R V CV + G +V E A + +P
Sbjct: 1004 QEACSLEPCPPRWKVMS-LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1062
Query: 832 SREACDMGPCTTAWFHSDW 850
+ C + CT W W
Sbjct: 1063 ASVPCLIADCTYRWHVGTW 1081
Score = 37.0 bits (84), Expect = 0.080
Identities = 42/152 (27%), Positives = 52/152 (34%), Gaps = 45/152 (29%)
Query: 730 GEWTS------CSRSCGPGTQHRQLQC---RQEFGGG---GSSVPPERCGHLPRPNITQS 777
G W+S CSRSCG G R+ QC R FGG G+ + E C TQ+
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCN-------TQA 437
Query: 778 C---QLRLCG---------------------HWEVGSPWSQCSVRCGRGQRSRQVRCVGN 813
C QL HW P SQ C R+ +
Sbjct: 438 CEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMK 497
Query: 814 NGDE-VSEQEC-ASGPPQPPSREACDMGPCTT 843
GD + C SGP + + C G C T
Sbjct: 498 RGDSFLDGTRCMPSGPREDGTLSLCVSGSCRT 529
Score = 35.8 bits (81), Expect = 0.18
Identities = 25/73 (34%), Positives = 33/73 (45%), Gaps = 8/73 (10%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRH-PEALLPRGQGPRP---QTSP 108
W CS CG G+QRR TC P Q P+P +H P+ + RG P Q +P
Sbjct: 1081 WMECSVSCGDGIQRRRDTCLGPQAQ----APVPADFCQHLPKPVTVRGCWAGPCVGQGTP 1136
Query: 109 ETLPLYRTQSRGR 121
+P + GR
Sbjct: 1137 SLVPHEEAAAPGR 1149
Score = 31.6 bits (70), Expect = 3.4
Identities = 13/30 (43%), Positives = 15/30 (50%)
Query: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
G W W + CS+ CG GV R R C P
Sbjct: 385 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNP 414
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 152 bits (384), Expect = 1e-36
Identities = 86/247 (34%), Positives = 131/247 (53%), Gaps = 9/247 (3%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQ----GSQRCE 419
C+G S++ + C CPP+ R QC +FNS + G+ +QW+P S+ C+
Sbjct: 90 CTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCD 149
Query: 420 LNCRPRGFRFYVRHTEKVQDGTLCQ-PGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCG 478
L+C + + +DGT C+ +CV+G+C GCDG+L S D CG+C
Sbjct: 150 LHCTTVDGQRQLM--VPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQ 207
Query: 479 GDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIING 538
GD S+C V+GN LGY + IPAGA +QI + + S++ LAL G NG
Sbjct: 208 GDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNG 267
Query: 539 NWAVDPPGSYRAGGTVFRYNRPPREEGKG-ESLSAEGPTTQPVDVYMIFQE-ENPGVFYQ 596
N+ VD P ++ GTV +Y RP G E + A+GPT Q ++V + Q ++P + ++
Sbjct: 268 NYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFE 327
Query: 597 YVISSPP 603
Y + PP
Sbjct: 328 YTLLQPP 334
Score = 115 bits (287), Expect = 2e-25
Identities = 69/189 (36%), Positives = 91/189 (48%), Gaps = 16/189 (8%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
WK H CSA+C GV +C+ R G E+D+ C A RP E C G C P W
Sbjct: 568 WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
Query: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGG-GSSVPPERC--GHLPRPNITQSCQLRLCG 784
E W+ CSR+CG G Q R ++C + G SSV + C RP ++C+ CG
Sbjct: 627 ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACG 686
Query: 785 -HWEVGSPWSQCSVRCG-RGQRSRQVRCVGNNGDEVSEQECASGP-PQPPSREACDMGPC 841
WE+ S WS+C+ +CG R +R +RC SE E P +P + C PC
Sbjct: 687 PQWEM-SEWSECTAKCGERSVVTRDIRC--------SEDEKLCDPNTRPVGEKNCTGPPC 737
Query: 842 TTAWFHSDW 850
W SDW
Sbjct: 738 DRQWTVSDW 746
Score = 94.4 bits (233), Expect = 4e-19
Identities = 60/196 (30%), Positives = 83/196 (42%), Gaps = 20/196 (10%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
W CS SCG+G C + + G + E C +P A PC CP +W
Sbjct: 741 WTVSDWGPCSGSCGQGRTIRHVYCKTSD-GRVVPESQCQMETKPLAI-HPCGDKNCPAHW 798
Query: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787
A +W C+ +CG G + R + C + G + CG +P +C R C W
Sbjct: 799 LAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWY 858
Query: 788 VGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFH 847
SPWS+C+ CG G R R V+C G ++ +P R+ACD+ PC T
Sbjct: 859 T-SPWSECTKTCGVGVRMRDVKCY--QGTDIVRG--CDPLVKPVGRQACDLQPCPT---- 909
Query: 848 SDWSSKVSPEPPAISC 863
EPP SC
Sbjct: 910 ---------EPPDDSC 916
Score = 91.3 bits (225), Expect = 4e-18
Identities = 63/206 (30%), Positives = 88/206 (42%), Gaps = 25/206 (12%)
Query: 655 PHPRTPLGSPAA--YWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPP 712
P R +PA W+ S C+A CG+ R + ++R+ DE+ C RP
Sbjct: 674 PEERKTCRNPACGPQWEMSEWSECTAKCGE---RSV---VTRDIRCSEDEKLCDPNTRP- 726
Query: 713 ASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRP 772
+ C G PC W +W CS SCG G R + C+ G VP +C +P
Sbjct: 727 VGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT---SDGRVVPESQCQMETKP 783
Query: 773 NITQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECASGP--- 827
C + C HW + W +C+ CGRG + R V C+ NG + + SGP
Sbjct: 784 LAIHPCGDKNCPAHW-LAQDWERCNTTCGRGVKKRLVLCMELANG----KPQTRSGPECG 838
Query: 828 --PQPPSREACDMGPCTTAWFHSDWS 851
+PP C PC W+ S WS
Sbjct: 839 LAKKPPEESTCFERPC-FKWYTSPWS 863
Score = 65.1 bits (157), Expect = 3e-10
Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 23/165 (13%)
Query: 643 QRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDE 702
+ Q ++ P HP PA +W C+ +CG+GV + + LC+ +G+
Sbjct: 774 ESQCQMETKPLAIHPCGDKNCPA-HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTR 832
Query: 703 RSCAAG-ARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQ--------- 752
G A+ P C PC W W+ C+++CG G + R ++C Q
Sbjct: 833 SGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCD 891
Query: 753 -----------EFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHW 786
+ + P + C P N + ++ LCGHW
Sbjct: 892 PLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHW 936
Score = 40.8 bits (94), Expect = 0.006
Identities = 22/73 (30%), Positives = 34/73 (46%), Gaps = 8/73 (10%)
Query: 4 WTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQ--GPEGV---WGPWVQWASCSQ 58
W W + LL+L++ V +G + +PT G + WG W +W +CS+
Sbjct: 5 WQCSCWAWFLLVLAV---VAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSR 61
Query: 59 PCGVGVQRRSRTC 71
CG GV + R C
Sbjct: 62 SCGGGVTSQERHC 74
Score = 37.4 bits (85), Expect = 0.061
Identities = 21/66 (31%), Positives = 26/66 (39%), Gaps = 1/66 (1%)
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAW 845
W++ S CS C G S CV +G EV + C + P E C C W
Sbjct: 568 WKLSSH-EPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
Query: 846 FHSDWS 851
S WS
Sbjct: 627 ETSSWS 632
Score = 36.2 bits (82), Expect = 0.14
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 701 DERSCAAGARPPASPEPCHGTPCPPYW--EAGEWTSCSRSCGPGTQHRQLQCRQE 753
D S + P S GT +W E +WT+CSRSCG G ++ C Q+
Sbjct: 23 DTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQ 77
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 152 bits (384), Expect = 1e-36
Identities = 86/247 (34%), Positives = 131/247 (53%), Gaps = 9/247 (3%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQ----GSQRCE 419
C+G S++ + C CPP+ R QC +FNS + G+ +QW+P S+ C+
Sbjct: 90 CTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPDDYVHISSKPCD 149
Query: 420 LNCRPRGFRFYVRHTEKVQDGTLCQ-PGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCG 478
L+C + + +DGT C+ +CV+G+C GCDG+L S D CG+C
Sbjct: 150 LHCTTVDGQRQLM--VPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQ 207
Query: 479 GDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIING 538
GD S+C V+GN LGY + IPAGA +QI + + S++ LAL G NG
Sbjct: 208 GDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNG 267
Query: 539 NWAVDPPGSYRAGGTVFRYNRPPREEGKG-ESLSAEGPTTQPVDVYMIFQE-ENPGVFYQ 596
N+ VD P ++ GTV +Y RP G E + A+GPT Q ++V + Q ++P + ++
Sbjct: 268 NYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFE 327
Query: 597 YVISSPP 603
Y + PP
Sbjct: 328 YTLLQPP 334
Score = 115 bits (287), Expect = 2e-25
Identities = 69/189 (36%), Positives = 91/189 (48%), Gaps = 16/189 (8%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
WK H CSA+C GV +C+ R G E+D+ C A RP E C G C P W
Sbjct: 568 WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
Query: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGG-GSSVPPERC--GHLPRPNITQSCQLRLCG 784
E W+ CSR+CG G Q R ++C + G SSV + C RP ++C+ CG
Sbjct: 627 ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACG 686
Query: 785 -HWEVGSPWSQCSVRCG-RGQRSRQVRCVGNNGDEVSEQECASGP-PQPPSREACDMGPC 841
WE+ S WS+C+ +CG R +R +RC SE E P +P + C PC
Sbjct: 687 PQWEM-SEWSECTAKCGERSVVTRDIRC--------SEDEKLCDPNTRPVGEKNCTGPPC 737
Query: 842 TTAWFHSDW 850
W SDW
Sbjct: 738 DRQWTVSDW 746
Score = 94.4 bits (233), Expect = 4e-19
Identities = 60/196 (30%), Positives = 83/196 (42%), Gaps = 20/196 (10%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
W CS SCG+G C + + G + E C +P A PC CP +W
Sbjct: 741 WTVSDWGPCSGSCGQGRTIRHVYCKTSD-GRVVPESQCQMETKPLAI-HPCGDKNCPAHW 798
Query: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787
A +W C+ +CG G + R + C + G + CG +P +C R C W
Sbjct: 799 LAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWY 858
Query: 788 VGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFH 847
SPWS+C+ CG G R R V+C G ++ +P R+ACD+ PC T
Sbjct: 859 T-SPWSECTKTCGVGVRMRDVKCY--QGTDIVRG--CDPLVKPVGRQACDLQPCPT---- 909
Query: 848 SDWSSKVSPEPPAISC 863
EPP SC
Sbjct: 910 ---------EPPDDSC 916
Score = 91.3 bits (225), Expect = 4e-18
Identities = 63/206 (30%), Positives = 88/206 (42%), Gaps = 25/206 (12%)
Query: 655 PHPRTPLGSPAA--YWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPP 712
P R +PA W+ S C+A CG+ R + ++R+ DE+ C RP
Sbjct: 674 PEERKTCRNPACGPQWEMSEWSECTAKCGE---RSV---VTRDIRCSEDEKLCDPNTRP- 726
Query: 713 ASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRP 772
+ C G PC W +W CS SCG G R + C+ G VP +C +P
Sbjct: 727 VGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT---SDGRVVPESQCQMETKP 783
Query: 773 NITQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECASGP--- 827
C + C HW + W +C+ CGRG + R V C+ NG + + SGP
Sbjct: 784 LAIHPCGDKNCPAHW-LAQDWERCNTTCGRGVKKRLVLCMELANG----KPQTRSGPECG 838
Query: 828 --PQPPSREACDMGPCTTAWFHSDWS 851
+PP C PC W+ S WS
Sbjct: 839 LAKKPPEESTCFERPC-FKWYTSPWS 863
Score = 65.1 bits (157), Expect = 3e-10
Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 23/165 (13%)
Query: 643 QRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDE 702
+ Q ++ P HP PA +W C+ +CG+GV + + LC+ +G+
Sbjct: 774 ESQCQMETKPLAIHPCGDKNCPA-HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTR 832
Query: 703 RSCAAG-ARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQ--------- 752
G A+ P C PC W W+ C+++CG G + R ++C Q
Sbjct: 833 SGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCD 891
Query: 753 -----------EFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHW 786
+ + P + C P N + ++ LCGHW
Sbjct: 892 PLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHW 936
Score = 40.8 bits (94), Expect = 0.006
Identities = 22/73 (30%), Positives = 34/73 (46%), Gaps = 8/73 (10%)
Query: 4 WTGRPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQ--GPEGV---WGPWVQWASCSQ 58
W W + LL+L++ V +G + +PT G + WG W +W +CS+
Sbjct: 5 WQCSCWAWFLLVLAV---VAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSR 61
Query: 59 PCGVGVQRRSRTC 71
CG GV + R C
Sbjct: 62 SCGGGVTSQERHC 74
Score = 37.4 bits (85), Expect = 0.061
Identities = 21/66 (31%), Positives = 26/66 (39%), Gaps = 1/66 (1%)
Query: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAW 845
W++ S CS C G S CV +G EV + C + P E C C W
Sbjct: 568 WKLSSH-EPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
Query: 846 FHSDWS 851
S WS
Sbjct: 627 ETSSWS 632
Score = 36.2 bits (82), Expect = 0.14
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 701 DERSCAAGARPPASPEPCHGTPCPPYW--EAGEWTSCSRSCGPGTQHRQLQCRQE 753
D S + P S GT +W E +WT+CSRSCG G ++ C Q+
Sbjct: 23 DTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQ 77
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 149 bits (376), Expect = 1e-35
Identities = 121/453 (26%), Positives = 182/453 (40%), Gaps = 70/453 (15%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
C G + + R CS CPPE D RA QC+A N + GQ Y+W P + C L C+
Sbjct: 66 CEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSN-DPDNPCSLKCQ 124
Query: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
+G V KV DGT C + D+C++G C GCD LGS + D CGVC GD ST
Sbjct: 125 AKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGST 184
Query: 484 CRLVSGNLTDR-GGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAV 542
CRLV G + ++ IP G+ +++ P YL + G G ++
Sbjct: 185 CRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQG---TKGENSL 241
Query: 543 DPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPG--------VF 594
G++ + + + P + E L GP T I + N G +F
Sbjct: 242 SSTGTFLVDNSSVDFQKFPDK----EILRMAGPLTAD----FIVKIRNSGSADSTVQFIF 293
Query: 595 YQYVI-----------------------SSPPPILENPTPEPPVPQLQPEILRVEPPLAP 631
YQ +I + + N PE ++ +P L
Sbjct: 294 YQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE 353
Query: 632 APRPARTPGTLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLC 691
+Q+ +P P PR W+ +ACS+SCG G+ C
Sbjct: 354 CNLDPCPASDGYKQI-MPYDLYHPLPR---------WEATPWTACSSSCGGGIQSRAVSC 403
Query: 692 ISRE---SGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQL 748
+ + ++E C + P + +PC+ CP W A EW+ C+ +CG G ++R +
Sbjct: 404 VEEDIQGHVTSVEEWKCMYTPKMPIA-QPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVV 461
Query: 749 QCRQEFG---GGGSSVPPERCGHLPRPNITQSC 778
C G GG C +P+I + C
Sbjct: 462 LCIDHRGMHTGG--------CSPKTKPHIKEEC 486
Score = 92.0 bits (227), Expect = 2e-18
Identities = 52/169 (30%), Positives = 74/169 (43%), Gaps = 22/169 (13%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSC---AAGARPPASPEPCHGTPCP 724
W+ CSA+CG G C S + ++ C +P + C+ PCP
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 725 -----------------PYWEAGEWTSCSRSCGPGTQHRQLQC-RQEFGGGGSSVPPERC 766
P WEA WT+CS SCG G Q R + C ++ G +SV +C
Sbjct: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
Query: 767 GHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG 815
+ P+ I Q C + C W + WS C+V CG+G R R V C+ + G
Sbjct: 421 MYTPKMPIAQPCNIFDCPKW-LAQEWSPCTVTCGQGLRYRVVLCIDHRG 468
Score = 33.9 bits (76), Expect = 0.68
Identities = 11/28 (39%), Positives = 15/28 (53%)
Query: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTC 71
+G+W W W+ CS+ CG G R C
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRC 60
Score = 33.5 bits (75), Expect = 0.89
Identities = 21/88 (23%), Positives = 36/88 (40%), Gaps = 15/88 (17%)
Query: 727 WEA-GEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-G 784
W+A G W+ CSR+CG G + +C G ++ C ++ P + + C
Sbjct: 36 WDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSA 95
Query: 785 HWEV-------------GSPWSQCSVRC 799
H +V P + CS++C
Sbjct: 96 HNDVKHHGQFYEWLPVSNDPDNPCSLKC 123
Score = 33.1 bits (74), Expect = 1.2
Identities = 13/34 (38%), Positives = 17/34 (50%)
Query: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDE 817
G W+ PWS+CS CG G RC+ + E
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCE 67
Score = 30.4 bits (67), Expect = 7.5
Identities = 11/27 (40%), Positives = 16/27 (59%)
Query: 53 WASCSQPCGVGVQRRSRTCQLPTVQLH 79
W +CS CG G+Q R+ +C +Q H
Sbjct: 385 WTACSSSCGGGIQSRAVSCVEEDIQGH 411
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 144 bits (362), Expect = 5e-34
Identities = 123/442 (27%), Positives = 183/442 (41%), Gaps = 35/442 (7%)
Query: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQL-YQWEPFTEVQGSQRCELNC 422
CSG + + CS+ CP D R QC ++ G + W P +RC L C
Sbjct: 600 CSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYC 659
Query: 423 RPRGFRFYVRHTEKVQDGTLCQ-PGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
R V V DGT C A +CV G C GCDG++GS ++ D CGVCGGD+
Sbjct: 660 ESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDN 719
Query: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRG-PGGRSIINGNW 540
S C++V G T GY K+ IPAGA L I ++ +S++LA++ G+ I+N
Sbjct: 720 SHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEEN 779
Query: 541 AVDPPG-SYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMI-FQEENPGVFYQYV 598
VD ++ A G + Y R+E E+L GP + V +I + + Y+Y+
Sbjct: 780 DVDASSKTFIAMGVEWEY----RDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYM 835
Query: 599 ISSPP-PILENPTPEPPVPQLQPEILRVEPPLAPAPRPAR-TPGTLQRQV---------- 646
I + +N E + + + P P ++ T +R++
Sbjct: 836 IHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFC 895
Query: 647 -RIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGK-GVWRPIFLCIS---RESGEELD 701
+ + A P W CS +CG+ G+ CI + +
Sbjct: 896 AALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVH 955
Query: 702 ERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSV 761
+ C P S C CP W AG W+ CS +CG GTQ R + CR G
Sbjct: 956 AKHC--NDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGIC- 1012
Query: 762 PPERCGHLPRPNITQSCQLRLC 783
RP ++C+L C
Sbjct: 1013 ------QEERPETARTCRLGPC 1028
Score = 97.4 bits (241), Expect = 5e-20
Identities = 69/221 (31%), Positives = 96/221 (43%), Gaps = 21/221 (9%)
Query: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCP-PY 726
W S CS CG G + C R + + CAA ++P A C+ C P
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPV 917
Query: 727 WEAGEWTSCSRSCG-PGTQHRQLQCRQEFGGGGS-SVPPERCGHLPRPNITQSCQLRLC- 783
W GEW CS++CG G Q R ++C Q + SV + C RP ++C LC
Sbjct: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RPESRRACSRELCP 976
Query: 784 GHWEVGSPWSQCSVRCGRGQRSRQVRC-VGNNGDEVSEQECASGPPQPPSREACDMGPC- 841
G W G PWSQCSV CG G + R V C ++ + ++E +P + C +GPC
Sbjct: 977 GRWRAG-PWSQCSVTCGNGTQERPVLCRTADDSFGICQEE------RPETARTCRLGPCP 1029
Query: 842 ------TTAWFHSDWSSKVSPEPPAISCILGNHAQ-DTSAF 875
+ + W S+ P+ P H Q D S F
Sbjct: 1030 RNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIF 1070
Score = 41.2 bits (95), Expect = 0.004
Identities = 17/38 (44%), Positives = 23/38 (60%), Gaps = 4/38 (10%)
Query: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHPS 81
+G WG W + SCS+ CG GV+ R+R C P HP+
Sbjct: 561 DGSWGAWSPFGSCSRTCGTGVKFRTRQCDNP----HPA 594
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 141 bits (356), Expect = 2e-33
Identities = 101/323 (31%), Positives = 143/323 (44%), Gaps = 52/323 (16%)
Query: 281 PRRPSSQGWASPQVAGRRPDPFPSVPRGRGQQGQGPWGT------GGTPHGPR--LEPDP 332
P S+G P+ RP P G GPWG GG R +P+P
Sbjct: 503 PGHLCSEGSCLPEEEVERPKPVAD----GGWAPWGPWGECSRTCGGGVQFSHRECKDPEP 558
Query: 333 QHPGAWLPLLSNGPHASSLWSLFAPSSPIPRCSGESEQLRACSQAPCPPEQPDPRALQCA 392
Q+ G + C G + ++C CPP+ R QC
Sbjct: 559 QNGGRY-------------------------CLGRRAKYQSCHTEECPPDGKSFREQQCE 593
Query: 393 AFNSQEFM---GQLYQWEP-FTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAP 448
+N+ + G L QW P + V RC+L CR RG + KV DGTLC P
Sbjct: 594 KYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETL 653
Query: 449 DICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPA 508
ICV G+C+ GCD ++ S R+ D CGVCGG ++CR VSG+LT GY I+ IPA
Sbjct: 654 AICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTN--YGYNDIVTIPA 711
Query: 509 GALRLQIAQ-----LRPSSNYLALRGPGGRSIINGNWAVDP-PGSYRAGGTVFRYNRPPR 562
GA + + Q ++ NYLAL+ G+ ++NGN A+ GT+ +Y+
Sbjct: 712 GATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYS---G 768
Query: 563 EEGKGESLSAEGPTTQPVDVYMI 585
E L + P +P+ V ++
Sbjct: 769 SIATLERLQSFRPLPEPLTVQLL 791
Score = 45.1 bits (105), Expect = 3e-04
Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 5/57 (8%)
Query: 727 WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC 783
W G+W+ CS +CG G Q R ++CR G ++ C +P + C+ +LC
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQASAT-----CNKALKPEDAKPCESQLC 887
Score = 43.1 bits (100), Expect = 0.001
Identities = 20/46 (43%), Positives = 24/46 (52%), Gaps = 4/46 (8%)
Query: 36 PTEEGQGP----EGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQ 77
P EE + P +G W PW W CS+ CG GVQ R C+ P Q
Sbjct: 514 PEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQ 559
Score = 32.3 bits (72), Expect = 2.0
Identities = 14/30 (46%), Positives = 18/30 (60%), Gaps = 2/30 (6%)
Query: 50 WV--QWASCSQPCGVGVQRRSRTCQLPTVQ 77
WV W+ CS CG G QRR+ C+ P+ Q
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQ 865
Score = 31.6 bits (70), Expect = 3.4
Identities = 16/41 (39%), Positives = 20/41 (48%), Gaps = 1/41 (2%)
Query: 775 TQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG 815
T Q L W +G WS+CS CG G + R V C +G
Sbjct: 825 TNIIQPLLHAQWVLGD-WSECSSTCGAGWQRRTVECRDPSG 864
Score = 30.4 bits (67), Expect = 7.5
Identities = 34/136 (25%), Positives = 44/136 (32%), Gaps = 16/136 (11%)
Query: 625 VEPPLAPAPRPARTPGTL---QRQVRIPQMPAPPHPRTPLGSP----AAYWKRV--GHSA 675
++ P A P P PG + Q + Q+ P P S A W
Sbjct: 426 LDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPL 485
Query: 676 CSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSC 735
C G W C G E SC P+P P+ G W C
Sbjct: 486 CHTKNGSLPWADGTPC---GPGHLCSEGSCLP-EEEVERPKPVADGGWAPW---GPWGEC 538
Query: 736 SRSCGPGTQHRQLQCR 751
SR+CG G Q +C+
Sbjct: 539 SRTCGGGVQFSHRECK 554
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 134 bits (337), Expect = 4e-31
Identities = 89/272 (32%), Positives = 130/272 (47%), Gaps = 25/272 (9%)
Query: 360 PIPR-----CSGESEQLRACSQAPCPPEQPDP-RALQCAAFNSQ-----EFMGQLYQWEP 408
P+PR C G + R+C+ CP R QCAA+N + F G + W P
Sbjct: 550 PVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPM-DWVP 608
Query: 409 -FTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGS 467
+T V +C+L C+ + +Y +V DGT C P + +CV GRC+ GCD I+GS
Sbjct: 609 RYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGS 668
Query: 468 GRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQL-RPS--SNY 524
++ D C VCGGD S C SG+ R GY ++ IPAGA + + Q P S Y
Sbjct: 669 KKKFDKCMVCGGDGSGCSKQSGSF--RKFRYGYNNVVTIPAGATHILVRQQGNPGHRSIY 726
Query: 525 LALRGPGGRSIINGNWAV--DPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDV 582
LAL+ P G +NG + + P G RY+ E+LS GP QP+ +
Sbjct: 727 LALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYS---GATAASETLSGHGPLAQPLTL 783
Query: 583 YMIF--QEENPGVFYQYVISSPPPILENPTPE 612
++ ++ + Y + + P P PTP+
Sbjct: 784 QVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQ 815
Score = 43.9 bits (102), Expect = 7e-04
Identities = 17/30 (56%), Positives = 18/30 (60%)
Query: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
G WGPW W CS+ CG GVQ SR C P
Sbjct: 521 GGWGPWGPWGDCSRTCGGGVQFSSRDCTRP 550
Score = 37.4 bits (85), Expect = 0.061
Identities = 47/197 (23%), Positives = 62/197 (31%), Gaps = 33/197 (16%)
Query: 697 GEELD-ERSCAAGARPPASPEPCHGTPCPPYWEAGEWTS---CSRSCGPGTQHRQLQCRQ 752
G++ D +R C P + P PC W +G C P Q
Sbjct: 440 GKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQ 499
Query: 753 EFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRC-- 810
GG RC H+ + Q + G W PW CS CG G + C
Sbjct: 500 ACMGG-------RCLHMDQ---LQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTR 549
Query: 811 -VGNNGDEVSE-----------QECASGPPQPPSREACDMGPCTTAWFHS-----DWSSK 853
V NG + E ++C +G E C T F S DW +
Sbjct: 550 PVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPR 609
Query: 854 VSPEPPAISCILGNHAQ 870
+ P C L AQ
Sbjct: 610 YTGVAPQDQCKLTCQAQ 626
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 130 bits (326), Expect = 7e-30
Identities = 106/397 (26%), Positives = 167/397 (42%), Gaps = 50/397 (12%)
Query: 359 SPIPR-----CSGESEQLRACSQAPCPPEQPDP-RALQCAAFNSQEFM------GQLYQW 406
+P+P+ C G+ + R+C+ CP R QC A N EF G +W
Sbjct: 588 NPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHN--EFSKASFGSGPAVEW 645
Query: 407 EP-FTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGIL 465
P + V RC+L C+ +G ++ KV DGT C P + +CV G+C+ GCD I+
Sbjct: 646 IPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRII 705
Query: 466 GSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQ-----LRP 520
S ++ D CGVCGG+ STC+ +SG++T GY I+ IP GA +++ Q R
Sbjct: 706 DSKKKFDKCGVCGGNGSTCKKISGSVT--SAKPGYHDIITIPTGATNIEVKQRNQRGSRN 763
Query: 521 SSNYLALRGPGGRSIINGNWAVDP-PGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQP 579
+ ++LA++ G I+NG++ + G V RY+ E + + P +P
Sbjct: 764 NGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYS---GSSAALERIRSFSPLKEP 820
Query: 580 --VDVYMIFQEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPAR 637
+ V + P + Y Y + +P ++ + +
Sbjct: 821 LTIQVLTVGNALRPKIKYTYFVKKKKESFN------AIPTFSAWVIEEWGECSKSCE--- 871
Query: 638 TPGTLQRQVR---IPQMPA--------PPHPRTPLGSPAAYWKRVGHSACSASCGKGVWR 686
G +R V I PA P R P W+ S+CS +CGKG +
Sbjct: 872 -LGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKK 930
Query: 687 PIFLCISRESGEELDERSCAAGARPPASPEPCHGTPC 723
C+S + G L SC +P + C C
Sbjct: 931 RSLKCLSHDGG-VLSHESCDPLKKPKHFIDFCTMAEC 966
Score = 75.5 bits (184), Expect = 2e-13
Identities = 40/129 (31%), Positives = 60/129 (46%), Gaps = 10/129 (7%)
Query: 716 EPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNIT 775
E + P W EW CS+SC G Q R ++CR G P C +P T
Sbjct: 847 ESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQ-----PASECAKEVKPAST 901
Query: 776 QSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSR-- 833
+ C C W++G WS CS CG+G + R ++C+ ++G +S + C P + P
Sbjct: 902 RPCADHPCPQWQLGE-WSSCSKTCGKGYKKRSLKCLSHDGGVLSHESC--DPLKKPKHFI 958
Query: 834 EACDMGPCT 842
+ C M C+
Sbjct: 959 DFCTMAECS 967
Score = 63.2 bits (152), Expect = 1e-09
Identities = 40/109 (36%), Positives = 54/109 (49%), Gaps = 9/109 (8%)
Query: 676 CSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSC 735
CS SC G R + C +G+ E CA +P AS PC PCP W+ GEW+SC
Sbjct: 866 CSKSCELGWQRRLVECRDI-NGQPASE--CAKEVKP-ASTRPCADHPCPQ-WQLGEWSSC 920
Query: 736 SRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRP-NITQSCQLRLC 783
S++CG G + R L+C GG + E C L +P + C + C
Sbjct: 921 SKTCGKGYKKRSLKCLSHDGG---VLSHESCDPLKKPKHFIDFCTMAEC 966
Score = 39.3 bits (90), Expect = 0.016
Identities = 15/30 (50%), Positives = 16/30 (53%)
Query: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
G WG W W CS+ CG GVQ R C P
Sbjct: 560 GSWGMWGPWGDCSRTCGGGVQYTMRECDNP 589
Score = 37.7 bits (86), Expect = 0.047
Identities = 38/155 (24%), Positives = 55/155 (35%), Gaps = 44/155 (28%)
Query: 675 ACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEA-GEWT 733
A SCG+G W C+++ + D P HG+ W G W
Sbjct: 529 ADGTSCGEGKWCINGKCVNKTDRKHFDT--------------PFHGS-----WGMWGPWG 569
Query: 734 SCSRSCGPGTQHRQLQCRQEF-GGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPW 792
CSR+CG G Q+ +C GG +R + +SC L C
Sbjct: 570 DCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRY-------RSCNLEDCPD------- 615
Query: 793 SQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGP 827
G+ R+ +C +N E S+ SGP
Sbjct: 616 -------NNGKTFREEQCEAHN--EFSKASFGSGP 641
Score = 30.4 bits (67), Expect = 7.5
Identities = 10/20 (50%), Positives = 15/20 (75%)
Query: 52 QWASCSQPCGVGVQRRSRTC 71
+W+SCS+ CG G ++RS C
Sbjct: 916 EWSSCSKTCGKGYKKRSLKC 935
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.136 0.456
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,175,923
Number of Sequences: 37866
Number of extensions: 3893235
Number of successful extensions: 29605
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 211
Number of HSP's successfully gapped in prelim test: 1426
Number of HSP's that attempted gapping in prelim test: 18173
Number of HSP's gapped (non-prelim): 10277
length of query: 877
length of database: 18,247,518
effective HSP length: 111
effective length of query: 766
effective length of database: 14,044,392
effective search space: 10758004272
effective search space used: 10758004272
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.