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Search of human proteins with 56119110
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56119110 family with sequence similarity 13, member A1
isoform a [Homo sapiens]
(1023 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56119110 family with sequence similarity 13, member A1 isofor... 2036 0.0
gi|62865869 family with sequence similarity 13, member A1 isofor... 1370 0.0
gi|156142188 hypothetical protein LOC51306 isoform 1 [Homo sapiens] 642 0.0
gi|156142190 hypothetical protein LOC51306 isoform 2 [Homo sapiens] 588 e-167
gi|156142192 hypothetical protein LOC51306 isoform 3 [Homo sapiens] 484 e-136
gi|50897856 hypothetical protein LOC220965 isoform 1 [Homo sapiens] 287 4e-77
gi|219555642 hypothetical protein LOC220965 isoform 3 [Homo sapi... 287 4e-77
gi|50897854 hypothetical protein LOC220965 isoform 2 [Homo sapiens] 144 3e-34
gi|4757766 Rho GTPase activating protein 1 [Homo sapiens] 116 1e-25
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa... 108 3e-23
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa... 106 1e-22
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 106 1e-22
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 105 2e-22
gi|226423858 PRR5-ARHGAP8 fusion protein [Homo sapiens] 105 3e-22
gi|66346660 Rho GTPase activating protein 8 isoform 2 [Homo sapi... 105 3e-22
gi|66346662 Rho GTPase activating protein 8 isoform 1 [Homo sapi... 105 3e-22
gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap... 97 1e-19
gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi... 97 1e-19
gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens] 95 3e-19
gi|95091988 Rho GTPase activating protein 6 isoform 3 [Homo sapi... 95 3e-19
gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo sapi... 95 3e-19
gi|5803145 ralA binding protein 1 [Homo sapiens] 91 6e-18
gi|51479148 Rho GTPase activating protein 20 [Homo sapiens] 91 6e-18
gi|59710111 Rho GTPase activating protein 28 isoform b [Homo sap... 91 6e-18
gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 91 7e-18
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 91 7e-18
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 91 7e-18
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap... 90 9e-18
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap... 90 9e-18
gi|59710113 Rho GTPase activating protein 28 isoform a [Homo sap... 90 1e-17
>gi|56119110 family with sequence similarity 13, member A1 isoform a
[Homo sapiens]
Length = 1023
Score = 2036 bits (5274), Expect = 0.0
Identities = 1023/1023 (100%), Positives = 1023/1023 (100%)
Query: 1 MGAGALAICQSKAAVRLKEDMKKIVAVPLNEQKDFTYQKLFGVSLQELERQGLTENGIPA 60
MGAGALAICQSKAAVRLKEDMKKIVAVPLNEQKDFTYQKLFGVSLQELERQGLTENGIPA
Sbjct: 1 MGAGALAICQSKAAVRLKEDMKKIVAVPLNEQKDFTYQKLFGVSLQELERQGLTENGIPA 60
Query: 61 VVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVCSAASLLKLF 120
VVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVCSAASLLKLF
Sbjct: 61 VVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVCSAASLLKLF 120
Query: 121 LRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHYCLLKYLCQFLTKVAK 180
LRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHYCLLKYLCQFLTKVAK
Sbjct: 121 LRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHYCLLKYLCQFLTKVAK 180
Query: 181 HHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILENYNTLFEVEYTENDH 240
HHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILENYNTLFEVEYTENDH
Sbjct: 181 HHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILENYNTLFEVEYTENDH 240
Query: 241 LRCENLARLIIVKEVYYKNSLPILLTRGLERDMPKPPPKTKIPKSRSEGSIQAHRVLQPE 300
LRCENLARLIIVKEVYYKNSLPILLTRGLERDMPKPPPKTKIPKSRSEGSIQAHRVLQPE
Sbjct: 241 LRCENLARLIIVKEVYYKNSLPILLTRGLERDMPKPPPKTKIPKSRSEGSIQAHRVLQPE 300
Query: 301 LSDGIPQLSLRLSYRKACLEDMNSAEGAISAKLVPSSQEDERPLSPFYLSAHVPQVSNVS 360
LSDGIPQLSLRLSYRKACLEDMNSAEGAISAKLVPSSQEDERPLSPFYLSAHVPQVSNVS
Sbjct: 301 LSDGIPQLSLRLSYRKACLEDMNSAEGAISAKLVPSSQEDERPLSPFYLSAHVPQVSNVS 360
Query: 361 ATGELLERTIRSAVEQHLFDVNNSGGQSSEDSESGTLSASSATSARQRRRQSKEQDEVRH 420
ATGELLERTIRSAVEQHLFDVNNSGGQSSEDSESGTLSASSATSARQRRRQSKEQDEVRH
Sbjct: 361 ATGELLERTIRSAVEQHLFDVNNSGGQSSEDSESGTLSASSATSARQRRRQSKEQDEVRH 420
Query: 421 GRDKGLINKENTPSGFNHLDDCILNTQEVEKVHKNTFGCAGERSKPKRQKSSTKLSELHD 480
GRDKGLINKENTPSGFNHLDDCILNTQEVEKVHKNTFGCAGERSKPKRQKSSTKLSELHD
Sbjct: 421 GRDKGLINKENTPSGFNHLDDCILNTQEVEKVHKNTFGCAGERSKPKRQKSSTKLSELHD 480
Query: 481 NQDGLVNMESLNSTRSHERTGPDDFEWMSDERKGNEKDGGHTQHFESPTMKIQEHPSLSD 540
NQDGLVNMESLNSTRSHERTGPDDFEWMSDERKGNEKDGGHTQHFESPTMKIQEHPSLSD
Sbjct: 481 NQDGLVNMESLNSTRSHERTGPDDFEWMSDERKGNEKDGGHTQHFESPTMKIQEHPSLSD 540
Query: 541 TKQQRNQDAGDQEESFVSEVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQA 600
TKQQRNQDAGDQEESFVSEVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQA
Sbjct: 541 TKQQRNQDAGDQEESFVSEVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQA 600
Query: 601 GRLIRQLLDEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDEQ 660
GRLIRQLLDEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDEQ
Sbjct: 601 GRLIRQLLDEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDEQ 660
Query: 661 EDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPSHSDKAANPEVLKWTNDLAKFRRQLK 720
EDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPSHSDKAANPEVLKWTNDLAKFRRQLK
Sbjct: 661 EDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPSHSDKAANPEVLKWTNDLAKFRRQLK 720
Query: 721 ESKLKISEEDLTPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKL 780
ESKLKISEEDLTPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKL
Sbjct: 721 ESKLKISEEDLTPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKL 780
Query: 781 QEKRAESSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVTKNERQVMKPLYDRYRL 840
QEKRAESSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVTKNERQVMKPLYDRYRL
Sbjct: 781 QEKRAESSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVTKNERQVMKPLYDRYRL 840
Query: 841 VKQILSRANTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDSNVKPDFMV 900
VKQILSRANTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDSNVKPDFMV
Sbjct: 841 VKQILSRANTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDSNVKPDFMV 900
Query: 901 TLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMRE 960
TLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMRE
Sbjct: 901 TLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMRE 960
Query: 961 EKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYSEYKHIKAKLRLLEVLISKRDTDS 1020
EKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYSEYKHIKAKLRLLEVLISKRDTDS
Sbjct: 961 EKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYSEYKHIKAKLRLLEVLISKRDTDS 1020
Query: 1021 KSM 1023
KSM
Sbjct: 1021 KSM 1023
>gi|62865869 family with sequence similarity 13, member A1 isoform b
[Homo sapiens]
Length = 697
Score = 1370 bits (3547), Expect = 0.0
Identities = 688/688 (100%), Positives = 688/688 (100%)
Query: 336 SSQEDERPLSPFYLSAHVPQVSNVSATGELLERTIRSAVEQHLFDVNNSGGQSSEDSESG 395
SSQEDERPLSPFYLSAHVPQVSNVSATGELLERTIRSAVEQHLFDVNNSGGQSSEDSESG
Sbjct: 10 SSQEDERPLSPFYLSAHVPQVSNVSATGELLERTIRSAVEQHLFDVNNSGGQSSEDSESG 69
Query: 396 TLSASSATSARQRRRQSKEQDEVRHGRDKGLINKENTPSGFNHLDDCILNTQEVEKVHKN 455
TLSASSATSARQRRRQSKEQDEVRHGRDKGLINKENTPSGFNHLDDCILNTQEVEKVHKN
Sbjct: 70 TLSASSATSARQRRRQSKEQDEVRHGRDKGLINKENTPSGFNHLDDCILNTQEVEKVHKN 129
Query: 456 TFGCAGERSKPKRQKSSTKLSELHDNQDGLVNMESLNSTRSHERTGPDDFEWMSDERKGN 515
TFGCAGERSKPKRQKSSTKLSELHDNQDGLVNMESLNSTRSHERTGPDDFEWMSDERKGN
Sbjct: 130 TFGCAGERSKPKRQKSSTKLSELHDNQDGLVNMESLNSTRSHERTGPDDFEWMSDERKGN 189
Query: 516 EKDGGHTQHFESPTMKIQEHPSLSDTKQQRNQDAGDQEESFVSEVPQSDLTALCDEKNWE 575
EKDGGHTQHFESPTMKIQEHPSLSDTKQQRNQDAGDQEESFVSEVPQSDLTALCDEKNWE
Sbjct: 190 EKDGGHTQHFESPTMKIQEHPSLSDTKQQRNQDAGDQEESFVSEVPQSDLTALCDEKNWE 249
Query: 576 EPIPAFSSWQRENSDSDEAHLSPQAGRLIRQLLDEDSDPMLSPRFYAYGQSRQYLDDTEV 635
EPIPAFSSWQRENSDSDEAHLSPQAGRLIRQLLDEDSDPMLSPRFYAYGQSRQYLDDTEV
Sbjct: 250 EPIPAFSSWQRENSDSDEAHLSPQAGRLIRQLLDEDSDPMLSPRFYAYGQSRQYLDDTEV 309
Query: 636 PPSPPNSHSFMRRRSSSLGSYDDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPS 695
PPSPPNSHSFMRRRSSSLGSYDDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPS
Sbjct: 310 PPSPPNSHSFMRRRSSSLGSYDDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPS 369
Query: 696 HSDKAANPEVLKWTNDLAKFRRQLKESKLKISEEDLTPRMRQRSNTLPKSFGSQLEKEDE 755
HSDKAANPEVLKWTNDLAKFRRQLKESKLKISEEDLTPRMRQRSNTLPKSFGSQLEKEDE
Sbjct: 370 HSDKAANPEVLKWTNDLAKFRRQLKESKLKISEEDLTPRMRQRSNTLPKSFGSQLEKEDE 429
Query: 756 KKQELVDKAIKPSVEATLESIQRKLQEKRAESSRPEDIKDMTKDQIANEKVALQKALLYY 815
KKQELVDKAIKPSVEATLESIQRKLQEKRAESSRPEDIKDMTKDQIANEKVALQKALLYY
Sbjct: 430 KKQELVDKAIKPSVEATLESIQRKLQEKRAESSRPEDIKDMTKDQIANEKVALQKALLYY 489
Query: 816 ESIHGRPVTKNERQVMKPLYDRYRLVKQILSRANTIPIIGSPSSKRRSPLLQPIIEGETA 875
ESIHGRPVTKNERQVMKPLYDRYRLVKQILSRANTIPIIGSPSSKRRSPLLQPIIEGETA
Sbjct: 490 ESIHGRPVTKNERQVMKPLYDRYRLVKQILSRANTIPIIGSPSSKRRSPLLQPIIEGETA 549
Query: 876 SFFKEIKEEEEGSEDDSNVKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCS 935
SFFKEIKEEEEGSEDDSNVKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCS
Sbjct: 550 SFFKEIKEEEEGSEDDSNVKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCS 609
Query: 936 QDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEE 995
QDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEE
Sbjct: 610 QDTGLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEE 669
Query: 996 YSEYKHIKAKLRLLEVLISKRDTDSKSM 1023
YSEYKHIKAKLRLLEVLISKRDTDSKSM
Sbjct: 670 YSEYKHIKAKLRLLEVLISKRDTDSKSM 697
>gi|156142188 hypothetical protein LOC51306 isoform 1 [Homo sapiens]
Length = 915
Score = 642 bits (1656), Expect = 0.0
Identities = 416/1021 (40%), Positives = 591/1021 (57%), Gaps = 124/1021 (12%)
Query: 21 MKKIVAVPLNEQKDFTYQKLFGVSLQELERQGLTENGIPAVVWNIVEYLTQHG-LTQEGL 79
M+K + L+ K+FG+ L EL++ G +N +P +V ++V+Y+ +HG L Q+GL
Sbjct: 1 MRKSSSPSLSNCNSVLANKIFGIPLDELQQGGHPDNEVPFIVRHVVDYIEEHGGLEQQGL 60
Query: 80 FRVNGNVKVVEQLRLKFESGVPVELGKDGDVCSAASLLKLFLRELPDSLITSALQPRFIQ 139
F+VNGN + VE LR +++SG V+L K+ DV SA SLL+ FL+ELP+ +I +L +Q
Sbjct: 61 FQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLLRFFLQELPEPVIPGSLHIHLMQ 120
Query: 140 LFQDGRNDVQES-SLRDLIKELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGP 198
L QD N+ + LR L+++LP +Y LLK+LC+FL VA HH + + ++LA VFGP
Sbjct: 121 LSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHH-EEIWSANSLAAVFGP 179
Query: 199 NCFHVPPGLEGMKEQDLCNKIMAKILENYNTLFEVEYTENDHLRCENLARLIIVKEVYYK 258
+ FH+ +E MKEQ++ ++IMA +LENY FE E +E +
Sbjct: 180 DVFHIYTDVEDMKEQEIVSRIMAGLLENYYEFFENE------------------EEDFSS 221
Query: 259 NSLPILLTRGLERDMPKPPPKTKIPKSRSEGSIQAHRVLQPELSDGIPQLSLRLSYRKAC 318
N L + I + +E S + + E + +P+ S
Sbjct: 222 NDL------------------SSITEQVNELSEEEEEDEKLEHIEELPEEGAEKSNDMPE 263
Query: 319 LEDMNSAEGAISAKLVPSSQEDERPLSPFYLSAHVPQVSNVSATGELLERTIRSAVEQHL 378
+ + E + + V ++ S H+ +S + A+ ++LERTIR+AVEQHL
Sbjct: 264 VVQLRMTENILESNSVTAT------------STHISPISILPASTDILERTIRAAVEQHL 311
Query: 379 FDVNNSGGQSSEDSESGTLSASSATSARQRRRQSKEQDEVRHGRDKGLINKENTPSGFNH 438
FD+ QSS D + L S + E H +G N+ +
Sbjct: 312 FDL-----QSSIDHDLKNLQQQSVVC--------NNEAESIHCDGEGSNNQID------- 351
Query: 439 LDDCILNTQEVEKVHKNTFGCAGERSKPKRQKSSTKLSELHDNQDGLVNMESLNSTRSHE 498
+ D I+N E + + SKP +ST L QD + E+ +T+S
Sbjct: 352 IADDIINASESNR----------DCSKPV---ASTNLDNEAMQQDCV--FENEENTQSVG 396
Query: 499 RTGPDDFEWMSDERKGNEKDGGHTQH----FESPTM---------KIQEHPSLSDTKQQR 545
E SD +G+ +DG + F+S + KI + + ++++
Sbjct: 397 IL----LEPCSD--RGDSEDGCLEREEYLLFDSDKLSHLILDSSSKICDLNANTESEVPG 450
Query: 546 NQDAGDQEESFVSEVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQAGRLIR 605
Q G Q E+ +P DL + D WEEP PAF SWQ E+S+S EA LSPQAGR+
Sbjct: 451 GQSVGVQGEAACVSIPHLDLKNVSDGDKWEEPFPAFKSWQ-EDSESGEAQLSPQAGRMNH 509
Query: 606 QLLDEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDEQEDLTP 665
L+ED P+LS R +GQS+++L D E S + SF R R SS S D+++ED TP
Sbjct: 510 HPLEEDCPPVLSHRSLDFGQSQRFLHDPEKLDSSSKALSFTRIRRSSFSSKDEKREDRTP 569
Query: 666 AQLTRRIQSLKKKIRKFEDRFEEEKKYRPSHSDKAANPEVLKWTNDLAKFRRQLKESKLK 725
QL +++Q KKIR+FE++FE E+ +PS+SD AANP+VLKW +L K R+Q+K++K K
Sbjct: 570 YQLVKKLQ---KKIRQFEEQFERERNSKPSYSDIAANPKVLKWMTELTKLRKQIKDAKHK 626
Query: 726 ISEEDLTPRMRQRSNTLPKSFGSQLEKEDEKKQE---LVDKAIKPSVEATLESIQRKLQE 782
S+ + P+ R RSNTLPKSFGS L+ EDE+ ++ ++ K KPS EATLE I ++L+E
Sbjct: 627 NSDGEFVPQTRPRSNTLPKSFGSSLDHEDEENEDEPKVIQKEKKPSKEATLELILKRLKE 686
Query: 783 KRAESSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVTKNERQVMKPLYDRYRLVK 842
KR E PEDIK MTKD + EK +LQK+LLYYES HGRPVTK ER ++KPLYDRYRLVK
Sbjct: 687 KRIERCLPEDIKKMTKDHLVEEKASLQKSLLYYESQHGRPVTKEERHIVKPLYDRYRLVK 746
Query: 843 QILSRANTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDSNVKPDFMVTL 902
Q+L+RA+ P++GSPS+KRR +LQPIIEGETA FF+EIKEEE ED N+ + L
Sbjct: 747 QMLTRASITPVLGSPSTKRRGQMLQPIIEGETAHFFEEIKEEE---EDGVNLSSELGDML 803
Query: 903 KTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEK 962
KT + L+ E D ++ K + D LS+ AAS+PELLE L + R EK
Sbjct: 804 KTAVQVQSSLENSESDV--------EENQEKLALDLRLSSSRAASMPELLEQLWKARAEK 855
Query: 963 KRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYSEYKHIKAKLRLLEVLISKRDTDSKS 1022
K++RK LR+FE+ F++QNGRN QKEDR P+ EEY EYK IKAKLRLLEVLISK+D+ SKS
Sbjct: 856 KKLRKTLREFEEAFYQQNGRNAQKEDRVPVLEEYREYKKIKAKLRLLEVLISKQDS-SKS 914
Query: 1023 M 1023
+
Sbjct: 915 I 915
>gi|156142190 hypothetical protein LOC51306 isoform 2 [Homo sapiens]
Length = 887
Score = 588 bits (1515), Expect = e-167
Identities = 397/1021 (38%), Positives = 569/1021 (55%), Gaps = 152/1021 (14%)
Query: 21 MKKIVAVPLNEQKDFTYQKLFGVSLQELERQGLTENGIPAVVWNIVEYLTQHG-LTQEGL 79
M+K + L+ K+FG+ L EL++ G +N +P +V ++V+Y+ +HG L Q+GL
Sbjct: 1 MRKSSSPSLSNCNSVLANKIFGIPLDELQQGGHPDNEVPFIVRHVVDYIEEHGGLEQQGL 60
Query: 80 FRVNGNVKVVEQLRLKFESGVPVELGKDGDVCSAASLLKLFLRELPDSLITSALQPRFIQ 139
F+VNGN + VE LR +++SG V+L K+ DV SA SLL+ FL+ELP+ +I +L +Q
Sbjct: 61 FQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLLRFFLQELPEPVIPGSLHIHLMQ 120
Query: 140 LFQDGRNDVQES-SLRDLIKELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGP 198
L QD N+ + LR L+++LP +Y LLK+LC+FL VA HH + + ++LA VFGP
Sbjct: 121 LSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHH-EEIWSANSLAAVFGP 179
Query: 199 NCFHVPPGLEGMKEQDLCNKIMAKILENYNTLFEVEYTENDHLRCENLARLIIVKEVYYK 258
+ FH+ +E MKEQ++ ++IMA +LENY FE E +E +
Sbjct: 180 DVFHIYTDVEDMKEQEIVSRIMAGLLENYYEFFENE------------------EEDFSS 221
Query: 259 NSLPILLTRGLERDMPKPPPKTKIPKSRSEGSIQAHRVLQPELSDGIPQLSLRLSYRKAC 318
N L + I + +E S + + E + +P+ S
Sbjct: 222 NDL------------------SSITEQVNELSEEEEEDEKLEHIEELPEEGAEKSNDMPE 263
Query: 319 LEDMNSAEGAISAKLVPSSQEDERPLSPFYLSAHVPQVSNVSATGELLERTIRSAVEQHL 378
+ + E + + V ++ S H+ +S + A+ ++LERTIR+AVEQHL
Sbjct: 264 VVQLRMTENILESNSVTAT------------STHISPISILPASTDILERTIRAAVEQHL 311
Query: 379 FDVNNSGGQSSEDSESGTLSASSATSARQRRRQSKEQDEVRHGRDKGLINKENTPSGFNH 438
FD+ QSS D + L S + E H +G N+ +
Sbjct: 312 FDL-----QSSIDHDLKNLQQQSVVC--------NNEAESIHCDGEGSNNQID------- 351
Query: 439 LDDCILNTQEVEKVHKNTFGCAGERSKPKRQKSSTKLSELHDNQDGLVNMESLNSTRSHE 498
+ D I+N E + + SKP +ST L QD + E+ +T+S
Sbjct: 352 IADDIINASESNR----------DCSKPV---ASTNLDNEAMQQDCV--FENEENTQSVG 396
Query: 499 RTGPDDFEWMSDERKGNEKDGGHTQH----FESPTM---------KIQEHPSLSDTKQQR 545
E SD +G+ +DG + F+S + KI + + ++++
Sbjct: 397 IL----LEPCSD--RGDSEDGCLEREEYLLFDSDKLSHLILDSSSKICDLNANTESEVPG 450
Query: 546 NQDAGDQEESFVSEVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQAGRLIR 605
Q G Q E+ +P DL + D WEEP PAF SWQ E+S+S EA LSPQAGR+
Sbjct: 451 GQSVGVQGEAACVSIPHLDLKNVSDGDKWEEPFPAFKSWQ-EDSESGEAQLSPQAGRMNH 509
Query: 606 QLLDEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDEQEDLTP 665
L+ED P+LS R +GQS+++L D E S + SF R R SS S D+++ED TP
Sbjct: 510 HPLEEDCPPVLSHRSLDFGQSQRFLHDPEKLDSSSKALSFTRIRRSSFSSKDEKREDRTP 569
Query: 666 AQLTRRIQSLKKKIRKFEDRFEEEKKYRPSHSDKAANPEVLKWTNDLAKFRRQLKESKLK 725
QL +++Q KKIR+FE++FE E+ +PS+SD AANP+VLKW +L K R+Q+K++K K
Sbjct: 570 YQLVKKLQ---KKIRQFEEQFERERNSKPSYSDIAANPKVLKWMTELTKLRKQIKDAKHK 626
Query: 726 ISEEDLTPRMRQRSNTLPKSFGSQLEKEDEKKQE---LVDKAIKPSVEATLESIQRKLQE 782
S+ + P+ R RSNTLPKSFGS L+ EDE+ ++ ++ K KPS EATLE I ++L+E
Sbjct: 627 NSDGEFVPQTRPRSNTLPKSFGSSLDHEDEENEDEPKVIQKEKKPSKEATLELILKRLKE 686
Query: 783 KRAESSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVTKNERQVMKPLYDRYRLVK 842
KR E PEDIK VTK ER ++KPLYDRYRLVK
Sbjct: 687 KRIERCLPEDIK----------------------------VTKEERHIVKPLYDRYRLVK 718
Query: 843 QILSRANTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDSNVKPDFMVTL 902
Q+L+RA+ P++GSPS+KRR +LQPIIEGETA FF+EIKEEEE D N+ + L
Sbjct: 719 QMLTRASITPVLGSPSTKRRGQMLQPIIEGETAHFFEEIKEEEE---DGVNLSSELGDML 775
Query: 903 KTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEK 962
KT + L+ E D + + K + D LS+ AAS+PELLE L + R EK
Sbjct: 776 KTAVQVQSSLENSESDVE--------ENQEKLALDLRLSSSRAASMPELLEQLWKARAEK 827
Query: 963 KRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYSEYKHIKAKLRLLEVLISKRDTDSKS 1022
K++RK LR+FE+ F++QNGRN QKEDR P+ EEY EYK IKAKLRLLEVLISK+D+ SKS
Sbjct: 828 KKLRKTLREFEEAFYQQNGRNAQKEDRVPVLEEYREYKKIKAKLRLLEVLISKQDS-SKS 886
Query: 1023 M 1023
+
Sbjct: 887 I 887
>gi|156142192 hypothetical protein LOC51306 isoform 3 [Homo sapiens]
Length = 791
Score = 484 bits (1247), Expect = e-136
Identities = 348/925 (37%), Positives = 492/925 (53%), Gaps = 173/925 (18%)
Query: 138 IQLFQDGRNDVQES-SLRDLIKELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVF 196
+QL QD N+ + LR L+++LP +Y LLK+LC+FL VA HH + + ++LA VF
Sbjct: 1 MQLSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHH-EEIWSANSLAAVF 59
Query: 197 GPNCFHVPPGLEGMKEQDLCNKIMAKILENYNTLFEVEYTENDHLRCENLARLIIVKEVY 256
GP+ FH+ +E MKEQ++ ++IMA +LENY FE E +E +
Sbjct: 60 GPDVFHIYTDVEDMKEQEIVSRIMAGLLENYYEFFENE------------------EEDF 101
Query: 257 YKNSLPILLTRGLERDMPKPPPKTKIPKSRSEGSIQAHRVLQPELSDGIPQLSLRLSYRK 316
N L + I + +E S + + E + +P+ S
Sbjct: 102 SSNDL------------------SSITEQVNELSEEEEEDEKLEHIEELPEEGAEKSNDM 143
Query: 317 ACLEDMNSAEGAISAKLVPSSQEDERPLSPFYLSAHVPQVSNVSATGELLERTIRSAVEQ 376
+ + E + + V ++ S H+ +S + A+ ++LERTIR+AVEQ
Sbjct: 144 PEVVQLRMTENILESNSVTAT------------STHISPISILPASTDILERTIRAAVEQ 191
Query: 377 HLFDVNNSGGQSSEDSESGTLSASSATSARQRRRQSKEQDEVRHGRDKGLINKENTPSGF 436
HLFD+ QSS D + L S + E H +G N+ +
Sbjct: 192 HLFDL-----QSSIDHDLKNLQQQSVVC--------NNEAESIHCDGEGSNNQID----- 233
Query: 437 NHLDDCILNTQEVEKVHKNTFGCAGERSKPKRQKSSTKLSELHDNQDGLVNMESLNSTRS 496
+ D I+N E + + SKP +ST L QD + E+ +T+S
Sbjct: 234 --IADDIINASESNR----------DCSKPV---ASTNLDNEAMQQDCV--FENEENTQS 276
Query: 497 HERTGPDDFEWMSDERKGNEKDGGHTQH----FESPTM---------KIQEHPSLSDTKQ 543
E SD +G+ +DG + F+S + KI + + ++++
Sbjct: 277 VGIL----LEPCSD--RGDSEDGCLEREEYLLFDSDKLSHLILDSSSKICDLNANTESEV 330
Query: 544 QRNQDAGDQEESFVSEVPQSDLTALCDEKNWE----------------------EPIPAF 581
Q G Q E+ +P DL + D WE EP PAF
Sbjct: 331 PGGQSVGVQGEAACVSIPHLDLKNVSDGDKWEASCPITFPLIDFKTMHLQRDGEEPFPAF 390
Query: 582 SSWQRENSDSDEAHLSPQAGRLIRQLLDEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPN 641
SWQ E+S+S EA LSPQAGR+ L+ED P+LS R +GQS+++L D E S
Sbjct: 391 KSWQ-EDSESGEAQLSPQAGRMNHHPLEEDCPPVLSHRSLDFGQSQRFLHDPEKLDSSSK 449
Query: 642 SHSFMRRRSSSLGSYDDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPSHSDKAA 701
+ SF R R SS S D+++ED TP QL +++Q KKIR+FE++FE E+ +PS+SD AA
Sbjct: 450 ALSFTRIRRSSFSSKDEKREDRTPYQLVKKLQ---KKIRQFEEQFERERNSKPSYSDIAA 506
Query: 702 NPEVLKWTNDLAKFRRQLKESKLKISEEDLTPRMRQRSNTLPKSFGSQLEKEDEKKQE-- 759
NP+VLKW +L K R+Q+K++K K S+ + P+ R RSNTLPKSFGS L+ EDE+ ++
Sbjct: 507 NPKVLKWMTELTKLRKQIKDAKHKNSDGEFVPQTRPRSNTLPKSFGSSLDHEDEENEDEP 566
Query: 760 -LVDKAIKPSVEATLESIQRKLQEKRAESSRPEDIKDMTKDQIANEKVALQKALLYYESI 818
++ K KPS EATLE I ++L+EKR E PEDIK
Sbjct: 567 KVIQKEKKPSKEATLELILKRLKEKRIERCLPEDIK------------------------ 602
Query: 819 HGRPVTKNERQVMKPLYDRYRLVKQILSRANTIPIIGSPSSKRRSPLLQPIIEGETASFF 878
VTK ER ++KPLYDRYRLVKQ+L+RA+ P++GSPS+KRR +LQPIIEGETA FF
Sbjct: 603 ----VTKEERHIVKPLYDRYRLVKQMLTRASITPVLGSPSTKRRGQMLQPIIEGETAHFF 658
Query: 879 KEIKEEEEGSEDDSNVKPDFMVTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDT 938
+EIKEEEE D N+ + LKT + L+ E D + + K + D
Sbjct: 659 EEIKEEEE---DGVNLSSELGDMLKTAVQVQSSLENSESDVE--------ENQEKLALDL 707
Query: 939 GLSNLHAASIPELLEHLQEMREEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYSE 998
LS+ AAS+PELLE L + R EKK++RK LR+FE+ F++QNGRN QKEDR P+ EEY E
Sbjct: 708 RLSSSRAASMPELLEQLWKARAEKKKLRKTLREFEEAFYQQNGRNAQKEDRVPVLEEYRE 767
Query: 999 YKHIKAKLRLLEVLISKRDTDSKSM 1023
YK IKAKLRLLEVLISK+D+ SKS+
Sbjct: 768 YKKIKAKLRLLEVLISKQDS-SKSI 791
>gi|50897856 hypothetical protein LOC220965 isoform 1 [Homo sapiens]
Length = 585
Score = 287 bits (734), Expect = 4e-77
Identities = 185/478 (38%), Positives = 255/478 (53%), Gaps = 59/478 (12%)
Query: 540 DTKQQRNQDAGDQEESFVSEVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQ 599
+T+Q N++ Q P S + L D + +P P Q E + E S
Sbjct: 162 ETRQDLNEEEAAQVHGVKDPAPASTQSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVG 221
Query: 600 AGRLIRQLLDEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDE 659
RL+ + D D+ P+LSPR + QS+++ D E PSPP++ FM RSSS S D
Sbjct: 222 TSRLLYHITDGDN-PLLSPRCSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCSCGDG 280
Query: 660 QEDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPSHSDKAANPEVLKWTNDLAKFRRQL 719
+E T QLT+ IQSLK+KIRKFE++FE+EKKYRPSH DK +NPEVLKW NDLAK R+QL
Sbjct: 281 KEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQL 340
Query: 720 KESKLKISEEDLTPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRK 779
KE KLK+SEE + N L + + K E S E T ++
Sbjct: 341 KELKLKLSEEQGSAPKGPPRNLLCE---QPTVPRENGKPEAAGPEPSSSGEETPDAALTC 397
Query: 780 LQEKRAESSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVTKNERQVMKPLYDRYR 839
L+E+R + ED K VTK ++ ++KPLYDRYR
Sbjct: 398 LKERREQLPPQEDSK----------------------------VTKQDKNLIKPLYDRYR 429
Query: 840 LVKQILSRANTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDSNVKPDFM 899
++KQILS +P L P I+ E S ++ +GS+ S P
Sbjct: 430 IIKQILS----------------TPSLIPTIQEEEDS----DEDRPQGSQQPSLADPASH 469
Query: 900 VTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMR 959
+ + + + ++ + + + D+ +SNLH A++P LL+HL+E R
Sbjct: 470 LPVGDHLT-------YSNETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETR 522
Query: 960 EEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYSEYKHIKAKLRLLEVLISKRD 1017
+KKR+RK LR+FE+ FF+Q GR+ QKEDR PMA+EY EYKHIKAKLRLLEVLISK+D
Sbjct: 523 ADKKRLRKALREFEEQFFKQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLISKQD 580
>gi|219555642 hypothetical protein LOC220965 isoform 3 [Homo sapiens]
Length = 502
Score = 287 bits (734), Expect = 4e-77
Identities = 185/478 (38%), Positives = 255/478 (53%), Gaps = 59/478 (12%)
Query: 540 DTKQQRNQDAGDQEESFVSEVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQ 599
+T+Q N++ Q P S + L D + +P P Q E + E S
Sbjct: 79 ETRQDLNEEEAAQVHGVKDPAPASTQSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVG 138
Query: 600 AGRLIRQLLDEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDE 659
RL+ + D D+ P+LSPR + QS+++ D E PSPP++ FM RSSS S D
Sbjct: 139 TSRLLYHITDGDN-PLLSPRCSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCSCGDG 197
Query: 660 QEDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPSHSDKAANPEVLKWTNDLAKFRRQL 719
+E T QLT+ IQSLK+KIRKFE++FE+EKKYRPSH DK +NPEVLKW NDLAK R+QL
Sbjct: 198 KEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQL 257
Query: 720 KESKLKISEEDLTPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRK 779
KE KLK+SEE + N L + + K E S E T ++
Sbjct: 258 KELKLKLSEEQGSAPKGPPRNLLCE---QPTVPRENGKPEAAGPEPSSSGEETPDAALTC 314
Query: 780 LQEKRAESSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVTKNERQVMKPLYDRYR 839
L+E+R + ED K VTK ++ ++KPLYDRYR
Sbjct: 315 LKERREQLPPQEDSK----------------------------VTKQDKNLIKPLYDRYR 346
Query: 840 LVKQILSRANTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDSNVKPDFM 899
++KQILS +P L P I+ E S ++ +GS+ S P
Sbjct: 347 IIKQILS----------------TPSLIPTIQEEEDS----DEDRPQGSQQPSLADPASH 386
Query: 900 VTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMR 959
+ + + + ++ + + + D+ +SNLH A++P LL+HL+E R
Sbjct: 387 LPVGDHLT-------YSNETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETR 439
Query: 960 EEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYSEYKHIKAKLRLLEVLISKRD 1017
+KKR+RK LR+FE+ FF+Q GR+ QKEDR PMA+EY EYKHIKAKLRLLEVLISK+D
Sbjct: 440 ADKKRLRKALREFEEQFFKQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLISKQD 497
>gi|50897854 hypothetical protein LOC220965 isoform 2 [Homo sapiens]
Length = 487
Score = 144 bits (364), Expect = 3e-34
Identities = 90/232 (38%), Positives = 132/232 (56%), Gaps = 28/232 (12%)
Query: 786 ESSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVTKNERQVMKPLYDRYRLVKQIL 845
+ P+ I +TK I + K ++K +E VTK ++ ++KPLYDRYR++KQIL
Sbjct: 279 DGKEPQTITQLTK-HIQSLKRKIRKFEEKFEQEKKYRVTKQDKNLIKPLYDRYRIIKQIL 337
Query: 846 SRANTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDSNVKPDFMVTLKTD 905
S +P L P I+ E S ++ +GS+ S P + +
Sbjct: 338 S----------------TPSLIPTIQEEEDSD----EDRPQGSQQPSLADPASHLPVGDH 377
Query: 906 FSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMREEKKRI 965
+ + ++ + + + D+ +SNLH A++P LL+HL+E R +KKR+
Sbjct: 378 LT-------YSNETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETRADKKRL 430
Query: 966 RKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYSEYKHIKAKLRLLEVLISKRD 1017
RK LR+FE+ FF+Q GR+ QKEDR PMA+EY EYKHIKAKLRLLEVLISK+D
Sbjct: 431 RKALREFEEQFFKQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLISKQD 482
Score = 116 bits (291), Expect = 9e-26
Identities = 103/330 (31%), Positives = 150/330 (45%), Gaps = 50/330 (15%)
Query: 540 DTKQQRNQDAGDQEESFVSEVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQ 599
+T+Q N++ Q P S + L D + +P P Q E + E S
Sbjct: 162 ETRQDLNEEEAAQVHGVKDPAPASTQSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVG 221
Query: 600 AGRLIRQLLDEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDE 659
RL+ + D D+ P+LSPR + QS+++ D E PSPP++ FM RSSS S D
Sbjct: 222 TSRLLYHITDGDN-PLLSPRCSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCSCGDG 280
Query: 660 QEDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPSHSDKAANPEVLKWTNDLAKFRRQL 719
+E T QLT+ IQSLK+KIRKFE++FE+EKKYR + DK ++K D + +Q+
Sbjct: 281 KEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRVTKQDK----NLIKPLYDRYRIIKQI 336
Query: 720 KESKLKI--------SEEDLTPRMRQRSNTLPKS---FGSQLEKEDE----------KKQ 758
+ I S+ED +Q S P S G L +E +K+
Sbjct: 337 LSTPSLIPTIQEEEDSDEDRPQGSQQPSLADPASHLPVGDHLTYSNETEPVRALLPDEKK 396
Query: 759 ELVDKAIKPS--VEATLESIQRKLQEKRAESSRPEDIKDMTKDQIANEKVALQKALLYYE 816
E+ A+ S EAT+ + L+E RA+ R L+KAL +E
Sbjct: 397 EVKPPALSMSNLHEATMPVLLDHLRETRADKKR------------------LRKALREFE 438
Query: 817 SIH----GRPVTKNERQVMKPLYDRYRLVK 842
GR K +R M Y Y+ +K
Sbjct: 439 EQFFKQTGRSPQKEDRIPMADEYYEYKHIK 468
>gi|4757766 Rho GTPase activating protein 1 [Homo sapiens]
Length = 439
Score = 116 bits (290), Expect = 1e-25
Identities = 65/191 (34%), Positives = 106/191 (55%), Gaps = 1/191 (0%)
Query: 41 FGVSLQELERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGV 100
FGVSLQ L+ + + IP V+ V YL H LT EG+FR + N +VV +++ K+ G+
Sbjct: 242 FGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGL 301
Query: 101 PVELGKDGDVCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKEL 160
PV+ + ++ A +LK FLRELP+ L+T L P + + ++L+ +++ L
Sbjct: 302 PVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQ-VLQTL 360
Query: 161 PDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIM 220
P+ +Y +L++L FL +++ H QN+M NLA VFGPN +K + N
Sbjct: 361 PEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFT 420
Query: 221 AKILENYNTLF 231
+L++ LF
Sbjct: 421 KFLLDHQGELF 431
>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
sapiens]
Length = 655
Score = 108 bits (269), Expect = 3e-23
Identities = 72/206 (34%), Positives = 115/206 (55%), Gaps = 11/206 (5%)
Query: 35 FTYQK-LFGVSLQELERQGLTENG--IPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQ 91
F+++K +FG L++ R P +V V+++ Q GL +EGLFR+ G +V++
Sbjct: 33 FSFRKGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKE 92
Query: 92 LRLKFESGVPVELGKDGDVCSAASLLKLFLRELPDSLITSALQPRFIQ----LFQDGRND 147
L+ F+ G + DV + ASLLKL+LRELP+ +I A F+ L ++
Sbjct: 93 LQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAG 152
Query: 148 VQESSLRDLIKELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFH--VPP 205
V+E L +K LP +Y LLKY+C+FL +V + N+M+V NLATVFGPN V
Sbjct: 153 VKE--LAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVED 210
Query: 206 GLEGMKEQDLCNKIMAKILENYNTLF 231
L M+ + ++M+ ++ ++ LF
Sbjct: 211 PLTIMEGTVVVQQLMSVMISKHDCLF 236
Score = 34.3 bits (77), Expect = 0.62
Identities = 69/328 (21%), Positives = 113/328 (34%), Gaps = 54/328 (16%)
Query: 445 NTQEVEKVHKNTFGCAGERSKPKRQKSSTKLSELHDNQDGLVNMESLNSTRSHERTGPDD 504
N + +EK G R + S TK+ H Q+G V M LNS T +
Sbjct: 349 NAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGT-HSVQNGTVRMGILNSDTLGNPTNVRN 407
Query: 505 FEWMSD------ERKGNEKDGGHTQHFESPTMKIQEHPSLSDTKQQRNQDAGDQEESFVS 558
W+ + + K E+ G QH T + QQ + D ++S
Sbjct: 408 MSWLPNGYVTLRDNKQKEQAGELGQHNRLST--------YDNVHQQFSMMNLDDKQSI-- 457
Query: 559 EVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQ----AGRLIRQLLD-EDSD 613
D W S + NS P+ G +LD D
Sbjct: 458 -----------DSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQD 506
Query: 614 PMLSPRFYAYGQSRQYLD--DTEVPPSPPNSHSFMRRRSS------SLGSYDDEQEDLTP 665
+ PR Y + + + S NS +F+ SS SL S ++
Sbjct: 507 DLSHPRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQK 566
Query: 666 AQLTRRIQSLKKK-------IRKFEDRFEEEKKYRPSHSDKAANPEVLK----WTNDLAK 714
+ RI+SL+++ + D ++E+K K N E K ND+
Sbjct: 567 IEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDM-- 624
Query: 715 FRRQLKESKLKISEEDLTPRMRQRSNTL 742
++++++ E + PR +R NT+
Sbjct: 625 LQKEMEQFFSTFGELTVEPRRTERGNTI 652
>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
sapiens]
Length = 653
Score = 106 bits (265), Expect = 1e-22
Identities = 66/179 (36%), Positives = 103/179 (57%), Gaps = 8/179 (4%)
Query: 59 PAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVCSAASLLK 118
P +V V+++ Q GL +EGLFR+ G +V++L+ F+ G + DV + ASLLK
Sbjct: 58 PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLK 117
Query: 119 LFLRELPDSLITSALQPRFIQ----LFQDGRNDVQESSLRDLIKELPDTHYCLLKYLCQF 174
L+LRELP+ +I A F+ L ++ V+E L +K LP +Y LLKY+C+F
Sbjct: 118 LYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKE--LAKQVKSLPVVNYNLLKYICRF 175
Query: 175 LTKVAKHHVQNRMNVHNLATVFGPNCFH--VPPGLEGMKEQDLCNKIMAKILENYNTLF 231
L +V + N+M+V NLATVFGPN V L M+ + ++M+ ++ ++ LF
Sbjct: 176 LDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDCLF 234
Score = 34.3 bits (77), Expect = 0.62
Identities = 69/328 (21%), Positives = 113/328 (34%), Gaps = 54/328 (16%)
Query: 445 NTQEVEKVHKNTFGCAGERSKPKRQKSSTKLSELHDNQDGLVNMESLNSTRSHERTGPDD 504
N + +EK G R + S TK+ H Q+G V M LNS T +
Sbjct: 347 NAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGT-HSVQNGTVRMGILNSDTLGNPTNVRN 405
Query: 505 FEWMSD------ERKGNEKDGGHTQHFESPTMKIQEHPSLSDTKQQRNQDAGDQEESFVS 558
W+ + + K E+ G QH T + QQ + D ++S
Sbjct: 406 MSWLPNGYVTLRDNKQKEQAGELGQHNRLST--------YDNVHQQFSMMNLDDKQSI-- 455
Query: 559 EVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQ----AGRLIRQLLD-EDSD 613
D W S + NS P+ G +LD D
Sbjct: 456 -----------DSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQD 504
Query: 614 PMLSPRFYAYGQSRQYLD--DTEVPPSPPNSHSFMRRRSS------SLGSYDDEQEDLTP 665
+ PR Y + + + S NS +F+ SS SL S ++
Sbjct: 505 DLSHPRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQK 564
Query: 666 AQLTRRIQSLKKK-------IRKFEDRFEEEKKYRPSHSDKAANPEVLK----WTNDLAK 714
+ RI+SL+++ + D ++E+K K N E K ND+
Sbjct: 565 IEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDM-- 622
Query: 715 FRRQLKESKLKISEEDLTPRMRQRSNTL 742
++++++ E + PR +R NT+
Sbjct: 623 LQKEMEQFFSTFGELTVEPRRTERGNTI 650
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 106 bits (265), Expect = 1e-22
Identities = 66/179 (36%), Positives = 103/179 (57%), Gaps = 8/179 (4%)
Query: 59 PAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVCSAASLLK 118
P +V V+++ Q GL +EGLFR+ G +V++L+ F+ G + DV + ASLLK
Sbjct: 153 PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLK 212
Query: 119 LFLRELPDSLITSALQPRFIQ----LFQDGRNDVQESSLRDLIKELPDTHYCLLKYLCQF 174
L+LRELP+ +I A F+ L ++ V+E L +K LP +Y LLKY+C+F
Sbjct: 213 LYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKE--LAKQVKSLPVVNYNLLKYICRF 270
Query: 175 LTKVAKHHVQNRMNVHNLATVFGPNCFH--VPPGLEGMKEQDLCNKIMAKILENYNTLF 231
L +V + N+M+V NLATVFGPN V L M+ + ++M+ ++ ++ LF
Sbjct: 271 LDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDCLF 329
Score = 34.3 bits (77), Expect = 0.62
Identities = 69/328 (21%), Positives = 113/328 (34%), Gaps = 54/328 (16%)
Query: 445 NTQEVEKVHKNTFGCAGERSKPKRQKSSTKLSELHDNQDGLVNMESLNSTRSHERTGPDD 504
N + +EK G R + S TK+ H Q+G V M LNS T +
Sbjct: 442 NAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGT-HSVQNGTVRMGILNSDTLGNPTNVRN 500
Query: 505 FEWMSD------ERKGNEKDGGHTQHFESPTMKIQEHPSLSDTKQQRNQDAGDQEESFVS 558
W+ + + K E+ G QH T + QQ + D ++S
Sbjct: 501 MSWLPNGYVTLRDNKQKEQAGELGQHNRLST--------YDNVHQQFSMMNLDDKQSI-- 550
Query: 559 EVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQ----AGRLIRQLLD-EDSD 613
D W S + NS P+ G +LD D
Sbjct: 551 -----------DSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQD 599
Query: 614 PMLSPRFYAYGQSRQYLD--DTEVPPSPPNSHSFMRRRSS------SLGSYDDEQEDLTP 665
+ PR Y + + + S NS +F+ SS SL S ++
Sbjct: 600 DLSHPRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQK 659
Query: 666 AQLTRRIQSLKKK-------IRKFEDRFEEEKKYRPSHSDKAANPEVLK----WTNDLAK 714
+ RI+SL+++ + D ++E+K K N E K ND+
Sbjct: 660 IEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDM-- 717
Query: 715 FRRQLKESKLKISEEDLTPRMRQRSNTL 742
++++++ E + PR +R NT+
Sbjct: 718 LQKEMEQFFSTFGELTVEPRRTERGNTI 745
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 105 bits (263), Expect = 2e-22
Identities = 64/183 (34%), Positives = 97/183 (53%), Gaps = 4/183 (2%)
Query: 59 PAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVCSAASLLK 118
P +V V+++ + GLT+EGLFR+ G +V L+ F+ G DV + ASLLK
Sbjct: 173 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVASLLK 232
Query: 119 LFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLR--DLIKELPDTHYCLLKYLCQFLT 176
L+LRELP+ ++ A F+ Q D E +L + LP +Y LL+Y+C+FL
Sbjct: 233 LYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKFLD 292
Query: 177 KVAKHHVQNRMNVHNLATVFGPNCF--HVPPGLEGMKEQDLCNKIMAKILENYNTLFEVE 234
+V + N+M+V NLATVFGPN V + M+ L +M ++ ++ LF
Sbjct: 293 EVQAYSNVNKMSVQNLATVFGPNILRPQVEDPVTIMEGTSLVQHLMTVLIRKHSQLFTAP 352
Query: 235 YTE 237
E
Sbjct: 353 VPE 355
>gi|226423858 PRR5-ARHGAP8 fusion protein [Homo sapiens]
Length = 555
Score = 105 bits (261), Expect = 3e-22
Identities = 65/200 (32%), Positives = 103/200 (51%), Gaps = 2/200 (1%)
Query: 41 FGVSLQELERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGV 100
FGVSLQ L+ + E IP V+ V YL + GL EGLFR + +V+ V +++ + G
Sbjct: 315 FGVSLQYLKDKNQGEL-IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGK 373
Query: 101 PVELGKDGDVCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKEL 160
PV GD+ A +LK FLRELP L+T + + + + ++ + R +++ L
Sbjct: 374 PVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGI-TCVESSLRVTGCRQILRSL 432
Query: 161 PDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIM 220
P+ +Y +L+YL FL V++ + N+MN NLA VFG N G+ + N
Sbjct: 433 PEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFT 492
Query: 221 AKILENYNTLFEVEYTENDH 240
++E Y +F +H
Sbjct: 493 ELLIEYYEKIFSTPEAPGEH 512
>gi|66346660 Rho GTPase activating protein 8 isoform 2 [Homo
sapiens]
Length = 433
Score = 105 bits (261), Expect = 3e-22
Identities = 65/200 (32%), Positives = 103/200 (51%), Gaps = 2/200 (1%)
Query: 41 FGVSLQELERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGV 100
FGVSLQ L+ + E IP V+ V YL + GL EGLFR + +V+ V +++ + G
Sbjct: 193 FGVSLQYLKDKNQGEL-IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGK 251
Query: 101 PVELGKDGDVCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKEL 160
PV GD+ A +LK FLRELP L+T + + + + ++ + R +++ L
Sbjct: 252 PVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGI-TCVESSLRVTGCRQILRSL 310
Query: 161 PDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIM 220
P+ +Y +L+YL FL V++ + N+MN NLA VFG N G+ + N
Sbjct: 311 PEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFT 370
Query: 221 AKILENYNTLFEVEYTENDH 240
++E Y +F +H
Sbjct: 371 ELLIEYYEKIFSTPEAPGEH 390
>gi|66346662 Rho GTPase activating protein 8 isoform 1 [Homo
sapiens]
Length = 464
Score = 105 bits (261), Expect = 3e-22
Identities = 65/200 (32%), Positives = 103/200 (51%), Gaps = 2/200 (1%)
Query: 41 FGVSLQELERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGV 100
FGVSLQ L+ + E IP V+ V YL + GL EGLFR + +V+ V +++ + G
Sbjct: 224 FGVSLQYLKDKNQGEL-IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGK 282
Query: 101 PVELGKDGDVCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKEL 160
PV GD+ A +LK FLRELP L+T + + + + ++ + R +++ L
Sbjct: 283 PVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGI-TCVESSLRVTGCRQILRSL 341
Query: 161 PDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIM 220
P+ +Y +L+YL FL V++ + N+MN NLA VFG N G+ + N
Sbjct: 342 PEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFT 401
Query: 221 AKILENYNTLFEVEYTENDH 240
++E Y +F +H
Sbjct: 402 ELLIEYYEKIFSTPEAPGEH 421
>gi|55770898 Rho GTPase activating protein 25 isoform a [Homo
sapiens]
Length = 645
Score = 96.7 bits (239), Expect = 1e-19
Identities = 58/179 (32%), Positives = 100/179 (55%), Gaps = 6/179 (3%)
Query: 58 IPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVCSAASLL 117
+P +V E++ +HG +EG+FR+ G +V+QLR F++G +D DV + ASLL
Sbjct: 176 VPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLL 235
Query: 118 KLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKE---LPDTHYCLLKYLCQF 174
KL+LR+LP+ ++ + F+ Q D + + ++L+K+ LP +Y LL Y+C+F
Sbjct: 236 KLYLRDLPEPVVPWSQYEGFLLCGQLTNAD-EAKAQQELMKQLSILPRDNYSLLSYICRF 294
Query: 175 LTKVAKHHVQNRMNVHNLATVFGPNCFH--VPPGLEGMKEQDLCNKIMAKILENYNTLF 231
L ++ + N+M+V NLATV G N V M+ ++M ++ ++ LF
Sbjct: 295 LHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLF 353
Score = 31.2 bits (69), Expect = 5.2
Identities = 45/176 (25%), Positives = 77/176 (43%), Gaps = 28/176 (15%)
Query: 604 IRQLLDE------DSDPML--SPRFYAYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGS 655
+RQL D D+ P L SP A S Q D + PNS + +++S
Sbjct: 490 LRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSG--- 546
Query: 656 YDDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPSHSDKAANPEVLKWTNDLAKF 715
+E+ D L R +Q L+K+I + +EE+ K + + N +V W + +
Sbjct: 547 --EEEID----SLQRMVQELRKEIETQKQMYEEQIK-----NLEKENYDV--WAK-VVRL 592
Query: 716 RRQLKESKLKISEEDLTPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEA 771
+L++ K K + +++ R +RS + LE E+ +E V +P EA
Sbjct: 593 NEELEKEKKKSAALEISLRNMERSREDVEKRNKALE---EEVKEFVKSMKEPKTEA 645
>gi|7661882 Rho GTPase activating protein 25 isoform b [Homo
sapiens]
Length = 638
Score = 96.7 bits (239), Expect = 1e-19
Identities = 58/179 (32%), Positives = 100/179 (55%), Gaps = 6/179 (3%)
Query: 58 IPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVCSAASLL 117
+P +V E++ +HG +EG+FR+ G +V+QLR F++G +D DV + ASLL
Sbjct: 169 VPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLL 228
Query: 118 KLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKE---LPDTHYCLLKYLCQF 174
KL+LR+LP+ ++ + F+ Q D + + ++L+K+ LP +Y LL Y+C+F
Sbjct: 229 KLYLRDLPEPVVPWSQYEGFLLCGQLTNAD-EAKAQQELMKQLSILPRDNYSLLSYICRF 287
Query: 175 LTKVAKHHVQNRMNVHNLATVFGPNCFH--VPPGLEGMKEQDLCNKIMAKILENYNTLF 231
L ++ + N+M+V NLATV G N V M+ ++M ++ ++ LF
Sbjct: 288 LHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLF 346
Score = 31.2 bits (69), Expect = 5.2
Identities = 45/176 (25%), Positives = 77/176 (43%), Gaps = 28/176 (15%)
Query: 604 IRQLLDE------DSDPML--SPRFYAYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGS 655
+RQL D D+ P L SP A S Q D + PNS + +++S
Sbjct: 483 LRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSG--- 539
Query: 656 YDDEQEDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPSHSDKAANPEVLKWTNDLAKF 715
+E+ D L R +Q L+K+I + +EE+ K + + N +V W + +
Sbjct: 540 --EEEID----SLQRMVQELRKEIETQKQMYEEQIK-----NLEKENYDV--WAK-VVRL 585
Query: 716 RRQLKESKLKISEEDLTPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEA 771
+L++ K K + +++ R +RS + LE E+ +E V +P EA
Sbjct: 586 NEELEKEKKKSAALEISLRNMERSREDVEKRNKALE---EEVKEFVKSMKEPKTEA 638
>gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens]
Length = 771
Score = 95.1 bits (235), Expect = 3e-19
Identities = 71/211 (33%), Positives = 104/211 (49%), Gaps = 27/211 (12%)
Query: 43 VSLQELERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPV 102
+SL + RQ +P +V + ++L +HGL G+FRV + K V QLR +F+ G+ V
Sbjct: 198 LSLNPIYRQ------VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDV 251
Query: 103 ELGKDGDVCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPD 162
L ++ V A+LLK FLR++PD L+T L FI + Q +L+ LI LP
Sbjct: 252 SLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLL-LEPEEQLGTLQLLIYLLPP 310
Query: 163 THYCLLKYLCQFLTKVAKHH-----------VQNRMNVHNLATVFGPNCFHVPPGLE--- 208
+ L L QFL+ VA+H N+M NLAT+FGPN H +
Sbjct: 311 CNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEF 370
Query: 209 ------GMKEQDLCNKIMAKILENYNTLFEV 233
+E ++ K++ENY LF V
Sbjct: 371 SVQSSARAEESTAIIAVVQKMIENYEALFMV 401
>gi|95091988 Rho GTPase activating protein 6 isoform 3 [Homo
sapiens]
Length = 765
Score = 95.1 bits (235), Expect = 3e-19
Identities = 71/211 (33%), Positives = 104/211 (49%), Gaps = 27/211 (12%)
Query: 43 VSLQELERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPV 102
+SL + RQ +P +V + ++L +HGL G+FRV + K V QLR +F+ G+ V
Sbjct: 401 LSLNPIYRQ------VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDV 454
Query: 103 ELGKDGDVCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPD 162
L ++ V A+LLK FLR++PD L+T L FI + Q +L+ LI LP
Sbjct: 455 SLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLL-LEPEEQLGTLQLLIYLLPP 513
Query: 163 THYCLLKYLCQFLTKVAKHH-----------VQNRMNVHNLATVFGPNCFHVPPGLE--- 208
+ L L QFL+ VA+H N+M NLAT+FGPN H +
Sbjct: 514 CNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEF 573
Query: 209 ------GMKEQDLCNKIMAKILENYNTLFEV 233
+E ++ K++ENY LF V
Sbjct: 574 SVQSSARAEESTAIIAVVQKMIENYEALFMV 604
>gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo
sapiens]
Length = 974
Score = 95.1 bits (235), Expect = 3e-19
Identities = 71/211 (33%), Positives = 104/211 (49%), Gaps = 27/211 (12%)
Query: 43 VSLQELERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPV 102
+SL + RQ +P +V + ++L +HGL G+FRV + K V QLR +F+ G+ V
Sbjct: 401 LSLNPIYRQ------VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDV 454
Query: 103 ELGKDGDVCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPD 162
L ++ V A+LLK FLR++PD L+T L FI + Q +L+ LI LP
Sbjct: 455 SLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFINTLL-LEPEEQLGTLQLLIYLLPP 513
Query: 163 THYCLLKYLCQFLTKVAKHH-----------VQNRMNVHNLATVFGPNCFHVPPGLE--- 208
+ L L QFL+ VA+H N+M NLAT+FGPN H +
Sbjct: 514 CNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEF 573
Query: 209 ------GMKEQDLCNKIMAKILENYNTLFEV 233
+E ++ K++ENY LF V
Sbjct: 574 SVQSSARAEESTAIIAVVQKMIENYEALFMV 604
>gi|5803145 ralA binding protein 1 [Homo sapiens]
Length = 655
Score = 90.9 bits (224), Expect = 6e-18
Identities = 55/184 (29%), Positives = 100/184 (54%), Gaps = 4/184 (2%)
Query: 18 KEDMKKIVAVPLNEQKDFTYQK-LFGVSLQELERQGLTENGI--PAVVWNIVEYLTQHGL 74
K+ KK + P Q D K +FG+ L + + + +GI PAV ++Y+ ++G+
Sbjct: 166 KKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGM 225
Query: 75 TQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVCSAASLLKLFLRELPDSLITSALQ 134
EG++RV+G V++L+ ++ L +D + + ASLLK +LR+LP++L+T L
Sbjct: 226 KCEGIYRVSGIKSKVDELKAAYDREESTNL-EDYEPNTVASLLKQYLRDLPENLLTKELM 284
Query: 135 PRFIQLFQDGRNDVQESSLRDLIKELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLAT 194
PRF + + + L+KELP+ +Y L+ +L + V ++ +MN+ N++
Sbjct: 285 PRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISI 344
Query: 195 VFGP 198
V P
Sbjct: 345 VLSP 348
>gi|51479148 Rho GTPase activating protein 20 [Homo sapiens]
Length = 1191
Score = 90.9 bits (224), Expect = 6e-18
Identities = 59/201 (29%), Positives = 101/201 (50%), Gaps = 8/201 (3%)
Query: 39 KLFGVSLQELERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFES 98
+LFG+SL + + +P V +++ +L Q G +G+FR + NVK +L+ K S
Sbjct: 361 QLFGISLPNI----CENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNS 416
Query: 99 GVPVELGKDGDVCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIK 158
GV V L + + AS+LK FLR +P S+ +S L ++ + G ++ + ++++ L+
Sbjct: 417 GVEVHLDCES-IFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLD 475
Query: 159 ELPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNK 218
+LP + LL+YL L + +H N+M NLA P+ P E + K
Sbjct: 476 QLPRANVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKK 535
Query: 219 IMAKI---LENYNTLFEVEYT 236
+ I +EN +F E T
Sbjct: 536 VSLLIQFLIENCLRIFGEEIT 556
>gi|59710111 Rho GTPase activating protein 28 isoform b [Homo
sapiens]
Length = 563
Score = 90.9 bits (224), Expect = 6e-18
Identities = 98/367 (26%), Positives = 157/367 (42%), Gaps = 49/367 (13%)
Query: 19 EDMKKIVAVPLNEQKDFTYQKLFGVSLQ--ELERQGLTENGI------------------ 58
EDMKKI + L E F FG+ L+ + E+ +NGI
Sbjct: 179 EDMKKIRHLSLIELTAFF--DAFGIQLKRNKTEKVKGRDNGIFGVPLTVLLDGDRKKDPG 236
Query: 59 ---PAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVC--SA 113
P V+ E + + GL EG+FR++G V+Q R + ++ + K +C A
Sbjct: 237 VKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREA 296
Query: 114 ASLLKLFLRELPDSLITSALQPRFIQLFQDGRN-DVQESSLRDLIKELPDTHYCLLKYLC 172
A +LK F RELP SL P FI L + G + VQ +L ++ LPD + + L
Sbjct: 297 AVMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVMALPDANRDAAQALM 356
Query: 173 QFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCN---KIMAKILENYNT 229
F KV + +NRM++ N++TV PN F +E L N I+ +L+
Sbjct: 357 TFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDYEELLLANTAAHIIRLMLKYQKI 416
Query: 230 LFEVEYTENDHLRCENLARLIIVKEVYYKNSLPILLTRGLERDMPKPPPKTKIPKSRS-- 287
L++V +R N A +++ K++ + +L + LER+ P + KS S
Sbjct: 417 LWKVPSFLITQVRRMNEATMLLKKQL--PSVRKLLRRKTLERETASPKTSKVLQKSPSAR 474
Query: 288 ------EGSIQAHRVLQPELSDGI--------PQLSLRLSYRKACLEDMNSAEGAISAKL 333
EG I+ H L ++S I + + Y L +A ++ K
Sbjct: 475 RMSDVPEGVIRVHAPLLSKVSMAIQLNNQTKAKDILAKFQYENRILHWQRAALSFLNGKW 534
Query: 334 VPSSQED 340
V +E+
Sbjct: 535 VKKEREE 541
>gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform d [Homo sapiens]
Length = 1133
Score = 90.5 bits (223), Expect = 7e-18
Identities = 60/192 (31%), Positives = 96/192 (50%), Gaps = 8/192 (4%)
Query: 48 LERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKD 107
L Q L ++ IP +V+ V+Y+TQ GLT EG++R G ++L K+
Sbjct: 654 LSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE 713
Query: 108 GD--VCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHY 165
G+ V +S LK FLR+LPD L T A + +++ + + + S R+L+ LP +
Sbjct: 714 GEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNR 773
Query: 166 CLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILE 225
+K L L V N+MNVHNLA VFGP F +G + +++ ++
Sbjct: 774 ATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQT----DGQDYK--AGRVVEDLIN 827
Query: 226 NYNTLFEVEYTE 237
+Y +F V+ E
Sbjct: 828 HYVVVFSVDEEE 839
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform a [Homo sapiens]
Length = 1205
Score = 90.5 bits (223), Expect = 7e-18
Identities = 60/192 (31%), Positives = 96/192 (50%), Gaps = 8/192 (4%)
Query: 48 LERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKD 107
L Q L ++ IP +V+ V+Y+TQ GLT EG++R G ++L K+
Sbjct: 715 LSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE 774
Query: 108 GD--VCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHY 165
G+ V +S LK FLR+LPD L T A + +++ + + + S R+L+ LP +
Sbjct: 775 GEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNR 834
Query: 166 CLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILE 225
+K L L V N+MNVHNLA VFGP F +G + +++ ++
Sbjct: 835 ATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQT----DGQDYK--AGRVVEDLIN 888
Query: 226 NYNTLFEVEYTE 237
+Y +F V+ E
Sbjct: 889 HYVVVFSVDEEE 900
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
isoform c [Homo sapiens]
Length = 1450
Score = 90.5 bits (223), Expect = 7e-18
Identities = 60/192 (31%), Positives = 96/192 (50%), Gaps = 8/192 (4%)
Query: 48 LERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKD 107
L Q L ++ IP +V+ V+Y+TQ GLT EG++R G ++L K+
Sbjct: 960 LSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE 1019
Query: 108 GD--VCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHY 165
G+ V +S LK FLR+LPD L T A + +++ + + + S R+L+ LP +
Sbjct: 1020 GEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNR 1079
Query: 166 CLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILE 225
+K L L V N+MNVHNLA VFGP F +G + +++ ++
Sbjct: 1080 ATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQT----DGQDYK--AGRVVEDLIN 1133
Query: 226 NYNTLFEVEYTE 237
+Y +F V+ E
Sbjct: 1134 HYVVVFSVDEEE 1145
>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
sapiens]
Length = 731
Score = 90.1 bits (222), Expect = 9e-18
Identities = 67/242 (27%), Positives = 118/242 (48%), Gaps = 29/242 (11%)
Query: 16 RLKEDMKKIVAV--PLN--EQKDFTYQKLFGVSLQEL-ERQGLTENGIPAVVWNIVEYLT 70
R++ +K+++A PL +++ ++FG L+ L +R+G T +P+ + + +
Sbjct: 492 RVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDT---VPSFLRLCIAAVD 548
Query: 71 QHGLTQEGLFRVNGNVKVVEQLRLKFESG----------VPVELGKDG----------DV 110
+ GL +G++RV+GN+ VV++LR + P + G++G D+
Sbjct: 549 KRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDI 608
Query: 111 CSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHYCLLKY 170
LKLFLRELP L+ L P F ++ S +++LI +P ++ L+Y
Sbjct: 609 HVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRY 668
Query: 171 LCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLC-NKIMAKILENYNT 229
L + L +V H +NRM HNL VFGP F L +++ +L N+ +
Sbjct: 669 LLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQLVQLMLTNFTS 728
Query: 230 LF 231
LF
Sbjct: 729 LF 730
>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
sapiens]
Length = 547
Score = 90.1 bits (222), Expect = 9e-18
Identities = 67/242 (27%), Positives = 118/242 (48%), Gaps = 29/242 (11%)
Query: 16 RLKEDMKKIVAV--PLN--EQKDFTYQKLFGVSLQEL-ERQGLTENGIPAVVWNIVEYLT 70
R++ +K+++A PL +++ ++FG L+ L +R+G T +P+ + + +
Sbjct: 308 RVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDT---VPSFLRLCIAAVD 364
Query: 71 QHGLTQEGLFRVNGNVKVVEQLRLKFESG----------VPVELGKDG----------DV 110
+ GL +G++RV+GN+ VV++LR + P + G++G D+
Sbjct: 365 KRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDI 424
Query: 111 CSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHYCLLKY 170
LKLFLRELP L+ L P F ++ S +++LI +P ++ L+Y
Sbjct: 425 HVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRY 484
Query: 171 LCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLC-NKIMAKILENYNT 229
L + L +V H +NRM HNL VFGP F L +++ +L N+ +
Sbjct: 485 LLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQLVQLMLTNFTS 544
Query: 230 LF 231
LF
Sbjct: 545 LF 546
>gi|59710113 Rho GTPase activating protein 28 isoform a [Homo
sapiens]
Length = 570
Score = 89.7 bits (221), Expect = 1e-17
Identities = 92/324 (28%), Positives = 144/324 (44%), Gaps = 41/324 (12%)
Query: 19 EDMKKIVAVPLNEQKDFTYQKLFGVSLQ--ELERQGLTENGI------------------ 58
EDMKKI + L E F FG+ L+ + E+ +NGI
Sbjct: 179 EDMKKIRHLSLIELTAFF--DAFGIQLKRNKTEKVKGRDNGIFGVPLTVLLDGDRKKDPG 236
Query: 59 ---PAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVC--SA 113
P V+ E + + GL EG+FR++G V+Q R + ++ + K +C A
Sbjct: 237 VKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREA 296
Query: 114 ASLLKLFLRELPDSLITSALQPRFIQLFQDGRN-DVQESSLRDLIKELPDTHYCLLKYLC 172
A +LK F RELP SL P FI L + G + VQ +L ++ LPD + + L
Sbjct: 297 AVMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVMALPDANRDAAQALM 356
Query: 173 QFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCN---KIMAKILENYNT 229
F KV + +NRM++ N++TV PN F +E L N I+ +L+
Sbjct: 357 TFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDYEELLLANTAAHIIRLMLKYQKI 416
Query: 230 LFEVEYTENDHLRCENLARLIIVKEVYYKNSLPILLTRGLERDMPKPPPKTKIPKSRS-- 287
L++V +R N A +++ K++ + +L + LER+ P + KS S
Sbjct: 417 LWKVPSFLITQVRRMNEATMLLKKQL--PSVRKLLRRKTLERETASPKTSKVLQKSPSAR 474
Query: 288 ------EGSIQAHRVLQPELSDGI 305
EG I+ H L ++S I
Sbjct: 475 RMSDVPEGVIRVHAPLLSKVSMAI 498
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,730,741
Number of Sequences: 37866
Number of extensions: 1995188
Number of successful extensions: 8347
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 125
Number of HSP's successfully gapped in prelim test: 365
Number of HSP's that attempted gapping in prelim test: 7247
Number of HSP's gapped (non-prelim): 1276
length of query: 1023
length of database: 18,247,518
effective HSP length: 112
effective length of query: 911
effective length of database: 14,006,526
effective search space: 12759945186
effective search space used: 12759945186
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.