Search of human proteins with 134288865

Search of human proteins with 134288865

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|134288865 solute carrier family 4, sodium bicarbonate
cotransporter, member 7 [Homo sapiens]
         (1214 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|134288865 solute carrier family 4, sodium bicarbonate cotrans...  2437   0.0  
gi|155722998 solute carrier family 4, sodium bicarbonate transpo...  1268   0.0  
gi|90403614 solute carrier family 4, sodium bicarbonate cotransp...  1259   0.0  
gi|90568034 solute carrier family 4, sodium bicarbonate cotransp...  1248   0.0  
gi|4507025 solute carrier family 4, sodium bicarbonate cotranspo...   910   0.0  
gi|148596928 solute carrier family 4, sodium bicarbonate cotrans...   910   0.0  
gi|197927160 solute carrier family 4, sodium bicarbonate cotrans...   909   0.0  
gi|19743827 sodium bicarbonate transporter 4 isoform c [Homo sap...   831   0.0  
gi|125987596 sodium bicarbonate transporter 4 isoform a [Homo sa...   821   0.0  
gi|151101449 solute carrier family 4, sodium bicarbonate cotrans...   745   0.0  
gi|156071474 solute carrier family 4, anion exchanger, member 2 ...   568   e-161
gi|157671951 solute carrier family 4, anion exchanger, member 3 ...   561   e-159
gi|157671953 solute carrier family 4, anion exchanger, member 3 ...   561   e-159
gi|4507021 solute carrier family 4, anion exchanger, member 1 [H...   510   e-144
gi|14042960 solute carrier family 4 member 11 [Homo sapiens]          216   8e-56
gi|32307128 nuclear receptor coactivator 6 [Homo sapiens]              41   0.006
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]               40   0.010
gi|9910278 keratinocytes associated transmembrane protein 2 [Hom...    38   0.051
gi|154354979 myosin X [Homo sapiens]                                   37   0.087
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ...    37   0.11 
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         37   0.15 
gi|23308699 transcription factor MAFB [Homo sapiens]                   36   0.19 
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        36   0.19 
gi|38176300 nestin [Homo sapiens]                                      36   0.25 
gi|22027648 lipin 1 [Homo sapiens]                                     36   0.25 
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]       36   0.25 
gi|13375827 phafin 2 [Homo sapiens]                                    35   0.33 
gi|112421108 capicua homolog [Homo sapiens]                            35   0.33 
gi|105554437 forkhead box B1 [Homo sapiens]                            35   0.33 
gi|222352122 hypothetical protein LOC284297 [Homo sapiens]             35   0.43 

>gi|134288865 solute carrier family 4, sodium bicarbonate
            cotransporter, member 7 [Homo sapiens]
          Length = 1214

 Score = 2437 bits (6317), Expect = 0.0
 Identities = 1214/1214 (100%), Positives = 1214/1214 (100%)

Query: 1    MERFRLEKKLPGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVPFSKESRRRHR 60
            MERFRLEKKLPGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVPFSKESRRRHR
Sbjct: 1    MERFRLEKKLPGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVPFSKESRRRHR 60

Query: 61   HRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELC 120
            HRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELC
Sbjct: 61   HRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELC 120

Query: 121  YRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRA 180
            YRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRA
Sbjct: 121  YRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRA 180

Query: 181  STLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKK 240
            STLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKK
Sbjct: 181  STLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKK 240

Query: 241  HSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCT 300
            HSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCT
Sbjct: 241  HSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCT 300

Query: 301  TPVPTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALK 360
            TPVPTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALK
Sbjct: 301  TPVPTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALK 360

Query: 361  GEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMR 420
            GEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMR
Sbjct: 361  GEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMR 420

Query: 421  KIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQ 480
            KIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQ
Sbjct: 421  KIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQ 480

Query: 481  YHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKS 540
            YHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKS
Sbjct: 481  YHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKS 540

Query: 541  VPSQEKRKIPVFHNGSTPTLGETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDF 600
            VPSQEKRKIPVFHNGSTPTLGETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDF
Sbjct: 541  VPSQEKRKIPVFHNGSTPTLGETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDF 600

Query: 601  KDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQ 660
            KDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQ
Sbjct: 601  KDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQ 660

Query: 661  PLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYIT 720
            PLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYIT
Sbjct: 661  PLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYIT 720

Query: 721  RFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLA 780
            RFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLA
Sbjct: 721  RFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLA 780

Query: 781  QWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSS 840
            QWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSS
Sbjct: 781  QWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSS 840

Query: 841  FLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGW 900
            FLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGW
Sbjct: 841  FLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGW 900

Query: 901  IISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGV 960
            IISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGV
Sbjct: 901  IISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGV 960

Query: 961  MLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMG 1020
            MLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMG
Sbjct: 961  MLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMG 1020

Query: 1021 LSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLW 1080
            LSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLW
Sbjct: 1021 LSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLW 1080

Query: 1081 KVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPE 1140
            KVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPE
Sbjct: 1081 KVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPE 1140

Query: 1141 SKKKKEDDKKKKEKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALKYSPDKPVSVKISFE 1200
            SKKKKEDDKKKKEKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALKYSPDKPVSVKISFE
Sbjct: 1141 SKKKKEDDKKKKEKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALKYSPDKPVSVKISFE 1200

Query: 1201 DEPRKKYVDAETSL 1214
            DEPRKKYVDAETSL
Sbjct: 1201 DEPRKKYVDAETSL 1214


>gi|155722998 solute carrier family 4, sodium bicarbonate
            transporter-like, member 10 [Homo sapiens]
          Length = 1088

 Score = 1268 bits (3280), Expect = 0.0
 Identities = 627/814 (77%), Positives = 700/814 (85%), Gaps = 13/814 (1%)

Query: 361  GEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMR 420
            G++Q    ++D   G + SPQSAP  ++N             SRENSTVDFSKVD++FM+
Sbjct: 243  GKKQSEPNSMDKNAGQVVSPQSAPACVENKNDV---------SRENSTVDFSKVDLHFMK 293

Query: 421  KIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQ 480
            KIP GAEASN+LVGE++FL+R ++AFVRL+PAVLL GL EVP+PTRFLF+LLGP GK  Q
Sbjct: 294  KIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGPLGKGQQ 353

Query: 481  YHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKS 540
            YHEIGRSIATLMTDE+FHDVAYKAKDRNDL+SGIDEFLDQVTVLPPGEWDPSIRIEPPK+
Sbjct: 354  YHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKN 413

Query: 541  VPSQEKRKIPVFHNGSTPTLGETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDF 600
            VPSQEKRKIP   NG T   GE      H +GPELQRTGR+FGGLILDIKRKAP+F SDF
Sbjct: 414  VPSQEKRKIPAVPNG-TAAHGEAEPHGGH-SGPELQRTGRIFGGLILDIKRKAPYFWSDF 471

Query: 601  KDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQ 660
            +DA SLQCLAS LFLYCACMSPVITFGGLLGEATEGRISAIESLFGAS+TGIAYSLF GQ
Sbjct: 472  RDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQ 531

Query: 661  PLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYIT 720
            PLTILGSTGPVLVFEKIL+KFC++Y LSYLSLR SIGLWT+ LCI+LVATDASSLVCYIT
Sbjct: 532  PLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYIT 591

Query: 721  RFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLA 780
            RFTEEAFA+LICIIFIYEALEKLF+L E Y  NMHN+L+ LT YSC C EP NPSN TL 
Sbjct: 592  RFTEEAFASLICIIFIYEALEKLFELSEAYPINMHNDLELLTQYSCNCVEPHNPSNGTLK 651

Query: 781  QWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSS 840
            +W++ NI+A +I W NLTVSECK L G ++G ACGH  PY+PDVLFW VILFF+T  LS+
Sbjct: 652  EWRESNISASDIIWENLTVSECKSLHGEYVGRACGHDHPYVPDVLFWSVILFFSTVTLSA 711

Query: 841  FLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGW 900
             LKQFKT RYFPTKVRS +SDFAVFLTI+ MV IDY +G+PSPKL VP  F+PT  +RGW
Sbjct: 712  TLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTRDDRGW 771

Query: 901  IISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGV 960
             ++PLG NPWWT++ A IPALLCTILIFMDQQITAVIINRKEHKLKKG GYHLDLLMV V
Sbjct: 772  FVTPLGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAV 831

Query: 961  MLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMG 1020
            MLGVCS+MGLPWFVAATVLSI+HVNSLK+ESECSAPGEQPKFLGIREQRVTGLMIFILMG
Sbjct: 832  MLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMG 891

Query: 1021 LSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLW 1080
             SVFMTS+LKFIPMPVLYGVFLYMG SSLKGIQ FDRIKLF MPAKHQPD IYLR+VPL 
Sbjct: 892  SSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFFDRIKLFWMPAKHQPDFIYLRHVPLR 951

Query: 1081 KVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPE 1140
            KVH+FT+IQ++CL LLW+IKVS AA+VFPMMVLALVFVRKLMDL FTKRELSWLDDLMPE
Sbjct: 952  KVHLFTIIQMSCLGLLWIIKVSRAAIVFPMMVLALVFVRKLMDLLFTKRELSWLDDLMPE 1011

Query: 1141 SKKKKEDDKKKKEKEEAERMLQDDDDTVHLPFEG 1174
            SKKKK +D +K  +EE   +  +D+ TV LP EG
Sbjct: 1012 SKKKKLEDAEK--EEEQSMLAMEDEGTVQLPLEG 1043



 Score =  372 bits (955), Expect = e-102
 Identities = 174/238 (73%), Positives = 209/238 (87%), Gaps = 2/238 (0%)

Query: 14  DEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVPFS-KESRRRHRHRGHKHHHRRRK 72
           DEEAVVD G T S + T FEKE+LE HR ++IGVHVP   ++S RRHRHRGHKH  R R 
Sbjct: 19  DEEAVVDRGGTRSILKTHFEKEDLEGHRTLFIGVHVPLGGRKSHRRHRHRGHKHRKRDR- 77

Query: 73  DKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKET 132
           +++S  EDGRESPS+DTPSQRVQFILGTEDDDEEHIPHDLFTE+DE+C+R+GE+ EW+ET
Sbjct: 78  ERDSGLEDGRESPSFDTPSQRVQFILGTEDDDEEHIPHDLFTELDEICWREGEDAEWRET 137

Query: 133 ARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLD 192
           ARWLKFEEDVEDGG+RWSKPYVATLSLHSLFELRSCILNGTV+LDM A+TL+EIADMVLD
Sbjct: 138 ARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLD 197

Query: 193 NMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERN 250
             ++SGQL+E +R  V EAL+K+HHHQN+K+ T+RIP+VRSFADIGKK S+P+ +++N
Sbjct: 198 QQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGKKQSEPNSMDKN 255


>gi|90403614 solute carrier family 4, sodium bicarbonate
            cotransporter, member 8 isoform a [Homo sapiens]
          Length = 1093

 Score = 1259 bits (3258), Expect = 0.0
 Identities = 634/842 (75%), Positives = 714/842 (84%), Gaps = 16/842 (1%)

Query: 361  GEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMR 420
            G++Q +   +D   G   SPQS P     + + E+K   +G + E+S VD SKVD++FM+
Sbjct: 242  GKKQSDPHLMD-KHGQTVSPQSVP-----TTNLEVK---NGVNCEHSPVDLSKVDLHFMK 292

Query: 421  KIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQ 480
            KIPTGAEASNVLVGEVD L+RPI+AFVRL+PAVLL+GLTEVP+PTRFLF+LLGP GK  Q
Sbjct: 293  KIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQ 352

Query: 481  YHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKS 540
            YHEIGRS+AT+MTDEIFHDVAYKAK+R+DLL+GIDEFLDQVTVLPPGEWDPSIRIEPPK+
Sbjct: 353  YHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKN 412

Query: 541  VPSQEKRKIPVFHNGSTPTLGETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDF 600
            VPSQEKRK+P   NG+   + + P     H+GPELQRTGRLFGGL+LDIKRKAP++ SD+
Sbjct: 413  VPSQEKRKMPGVPNGNVCHIEQEPHGG--HSGPELQRTGRLFGGLVLDIKRKAPWYWSDY 470

Query: 601  KDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQ 660
            +DALSLQCLAS LFLYCACMSPVITFGGLLGEATEGRISAIESLFGAS+TGIAYSLFAGQ
Sbjct: 471  RDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQ 530

Query: 661  PLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYIT 720
             LTILGSTGPVLVFEKIL+KFC+DY LSYLSLR  IGLWT+FLCIVLVATDASSLVCYIT
Sbjct: 531  ALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYIT 590

Query: 721  RFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLA 780
            RFTEEAFA+LICIIFIYEA+EKL  L ETY  +MH+ LD L+ Y C CT P NP+N TL 
Sbjct: 591  RFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQ 650

Query: 781  QWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSS 840
             WK  NI    + W NLTVSEC+++ G F+GSACGHHGPY PDVLFW  ILFFTTF LSS
Sbjct: 651  YWKDHNIVTAEVHWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFTTFILSS 710

Query: 841  FLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGW 900
             LK FKT RYFPT+VRS +SDFAVFLTI  MV ID+L+GVPSPKL VP  F+PT  +RGW
Sbjct: 711  TLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGW 770

Query: 901  IISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGV 960
            II+P+G NPWWT++ A IPALLCTILIFMDQQITAVIINRKEHKLKKG GYHLDLLMV +
Sbjct: 771  IINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAI 830

Query: 961  MLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMG 1020
            MLGVCS+MGLPWFVAATVLSI+HVNSLK+ESECSAPGEQPKFLGIREQRVTGLMIF+LMG
Sbjct: 831  MLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMG 890

Query: 1021 LSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLW 1080
             SVFMT++LKFIPMPVLYGVFLYMGVSSL+GIQ FDR+KLFGMPAKHQPD IYLR+VPL 
Sbjct: 891  CSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLR 950

Query: 1081 KVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPE 1140
            KVH+FT+IQLTCLVLLWVIK S AA+VFPMMVLALVFVRK+MDLCF+KRELSWLDDLMPE
Sbjct: 951  KVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLDDLMPE 1010

Query: 1141 SKKKKEDD--KKKKEKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALKYSPDKPVSVKIS 1198
            SKKKK DD  KK KE+EEAE+ML+   D    P E   LL  P K +    D P  + IS
Sbjct: 1011 SKKKKLDDAKKKAKEEEEAEKMLEIGGD--KFPLESRKLLSSPGKNISCRCD-PSEINIS 1067

Query: 1199 FE 1200
             E
Sbjct: 1068 DE 1069



 Score =  335 bits (860), Expect = 1e-91
 Identities = 154/243 (63%), Positives = 200/243 (82%), Gaps = 1/243 (0%)

Query: 13  PDEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVPFSKESRRRHRHRGHKHHHRRRK 72
           PDEEAVVD G TS+ +N  +EKEELE HR +Y+GV +P  ++S R HR  G KH  R R 
Sbjct: 18  PDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHGQKHRRRGRG 77

Query: 73  DKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKET 132
              S  E+G E+ ++DTPSQRVQFILGTE+D EEH+PH+LFTE+DE+C ++GE+ EWKET
Sbjct: 78  KGASQGEEGLEALAHDTPSQRVQFILGTEED-EEHVPHELFTELDEICMKEGEDAEWKET 136

Query: 133 ARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLD 192
           ARWLKFEEDVEDGG+RWSKPYVATLSLHSLFELRSC++NGTV+LDM A++++EI+D++LD
Sbjct: 137 ARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILD 196

Query: 193 NMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGE 252
               S  L++S+R  VREALLK+HHHQNEK+  + IP+VRSFA++GKK SDPHL++++G+
Sbjct: 197 QQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGKKQSDPHLMDKHGQ 256

Query: 253 GLS 255
            +S
Sbjct: 257 TVS 259


>gi|90568034 solute carrier family 4, sodium bicarbonate
            cotransporter, member 8 isoform b [Homo sapiens]
          Length = 1044

 Score = 1248 bits (3229), Expect = 0.0
 Identities = 618/796 (77%), Positives = 693/796 (87%), Gaps = 11/796 (1%)

Query: 361  GEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMR 420
            G++Q +   +D   G   SPQS P     + + E+K   +G + E+S VD SKVD++FM+
Sbjct: 242  GKKQSDPHLMD-KHGQTVSPQSVP-----TTNLEVK---NGVNCEHSPVDLSKVDLHFMK 292

Query: 421  KIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQ 480
            KIPTGAEASNVLVGEVD L+RPI+AFVRL+PAVLL+GLTEVP+PTRFLF+LLGP GK  Q
Sbjct: 293  KIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQ 352

Query: 481  YHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKS 540
            YHEIGRS+AT+MTDEIFHDVAYKAK+R+DLL+GIDEFLDQVTVLPPGEWDPSIRIEPPK+
Sbjct: 353  YHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKN 412

Query: 541  VPSQEKRKIPVFHNGSTPTLGETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDF 600
            VPSQEKRK+P   NG+   + + P     H+GPELQRTGRLFGGL+LDIKRKAP++ SD+
Sbjct: 413  VPSQEKRKMPGVPNGNVCHIEQEPHGG--HSGPELQRTGRLFGGLVLDIKRKAPWYWSDY 470

Query: 601  KDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQ 660
            +DALSLQCLAS LFLYCACMSPVITFGGLLGEATEGRISAIESLFGAS+TGIAYSLFAGQ
Sbjct: 471  RDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQ 530

Query: 661  PLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYIT 720
             LTILGSTGPVLVFEKIL+KFC+DY LSYLSLR  IGLWT+FLCIVLVATDASSLVCYIT
Sbjct: 531  ALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYIT 590

Query: 721  RFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLA 780
            RFTEEAFA+LICIIFIYEA+EKL  L ETY  +MH+ LD L+ Y C CT P NP+N TL 
Sbjct: 591  RFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQ 650

Query: 781  QWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSS 840
             WK  NI    + W NLTVSEC+++ G F+GSACGHHGPY PDVLFW  ILFFTTF LSS
Sbjct: 651  YWKDHNIVTAEVHWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFTTFILSS 710

Query: 841  FLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGW 900
             LK FKT RYFPT+VRS +SDFAVFLTI  MV ID+L+GVPSPKL VP  F+PT  +RGW
Sbjct: 711  TLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGW 770

Query: 901  IISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGV 960
            II+P+G NPWWT++ A IPALLCTILIFMDQQITAVIINRKEHKLKKG GYHLDLLMV +
Sbjct: 771  IINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAI 830

Query: 961  MLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMG 1020
            MLGVCS+MGLPWFVAATVLSI+HVNSLK+ESECSAPGEQPKFLGIREQRVTGLMIF+LMG
Sbjct: 831  MLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMG 890

Query: 1021 LSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLW 1080
             SVFMT++LKFIPMPVLYGVFLYMGVSSL+GIQ FDR+KLFGMPAKHQPD IYLR+VPL 
Sbjct: 891  CSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLR 950

Query: 1081 KVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPE 1140
            KVH+FT+IQLTCLVLLWVIK S AA+VFPMMVLALVFVRK+MDLCF+KRELSWLDDLMPE
Sbjct: 951  KVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLDDLMPE 1010

Query: 1141 SKKKKEDDKKKKEKEE 1156
            SKKKK DD KKK KEE
Sbjct: 1011 SKKKKLDDAKKKAKEE 1026



 Score =  335 bits (860), Expect = 1e-91
 Identities = 154/243 (63%), Positives = 200/243 (82%), Gaps = 1/243 (0%)

Query: 13  PDEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVPFSKESRRRHRHRGHKHHHRRRK 72
           PDEEAVVD G TS+ +N  +EKEELE HR +Y+GV +P  ++S R HR  G KH  R R 
Sbjct: 18  PDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHGQKHRRRGRG 77

Query: 73  DKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKET 132
              S  E+G E+ ++DTPSQRVQFILGTE+D EEH+PH+LFTE+DE+C ++GE+ EWKET
Sbjct: 78  KGASQGEEGLEALAHDTPSQRVQFILGTEED-EEHVPHELFTELDEICMKEGEDAEWKET 136

Query: 133 ARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLD 192
           ARWLKFEEDVEDGG+RWSKPYVATLSLHSLFELRSC++NGTV+LDM A++++EI+D++LD
Sbjct: 137 ARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLLDMHANSIEEISDLILD 196

Query: 193 NMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGE 252
               S  L++S+R  VREALLK+HHHQNEK+  + IP+VRSFA++GKK SDPHL++++G+
Sbjct: 197 QQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGKKQSDPHLMDKHGQ 256

Query: 253 GLS 255
            +S
Sbjct: 257 TVS 259


>gi|4507025 solute carrier family 4, sodium bicarbonate cotransporter,
            member 4 isoform 2 [Homo sapiens]
          Length = 1035

 Score =  910 bits (2353), Expect = 0.0
 Identities = 466/829 (56%), Positives = 592/829 (71%), Gaps = 35/829 (4%)

Query: 379  SPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDF 438
            SP     NL +S   +I         +N           FM+K+P  AEASNVLVGEVDF
Sbjct: 201  SPAMTHRNLTSSSLNDISDKPEKDQLKNK----------FMKKLPRDAEASNVLVGEVDF 250

Query: 439  LERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQYHEIGRSIATLMTDEIFH 498
            L+ P IAFVRL  AV+L  LTEVPVPTRFLF+LLGP GKA  YHEIGR+IATLM+DE+FH
Sbjct: 251  LDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFH 310

Query: 499  DVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPVFHNGSTP 558
            D+AYKAKDR+DL++GIDEFLD+V VLPPGEWDP+IRIEPPKS+PS +KRK       +  
Sbjct: 311  DIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQ 370

Query: 559  TLGETPKEAAHHAG-----PELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASIL 613
              G+TP +  H  G      ELQRTGR  GGLI DIKRKAPFF SDF DAL++Q L++IL
Sbjct: 371  MNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAIL 430

Query: 614  FLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLV 673
            F+Y A ++  ITFGGLLG+AT+     +ES  G +++G  + LFAGQPLTIL STGPVLV
Sbjct: 431  FIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLV 490

Query: 674  FEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICI 733
            FE++L+ F +D    YL  R  IGLW++FLC++LVATDAS LV Y TRFTEE F++LI  
Sbjct: 491  FERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISF 550

Query: 734  IFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSN------ETLAQWKKDNI 787
            IFIY+A +K+  L + Y  N +  +   T +SC C  PP+P+N       TLA      +
Sbjct: 551  IFIYDAFKKMIKLADYYPINSNFKVGYNTLFSCTCV-PPDPANISISNDTTLAPEYLPTM 609

Query: 788  TA----HNIS--WRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSSF 841
            ++    HN +  W  L+  EC K  G  +G+ C     ++PD+     ILF  T+  S  
Sbjct: 610  SSTDMYHNTTFDWAFLSKKECSKYGGNLVGNNCN----FVPDITLMSFILFLGTYTSSMA 665

Query: 842  LKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGWI 901
            LK+FKT  YFPT  R  ISDFA+ L+I+I   ID LVGV +PKL VP +F+PT P RGW 
Sbjct: 666  LKKFKTSPYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWF 725

Query: 902  ISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVM 961
            + P G+NPWW  L AAIPALL TILIFMDQQITAVI+NRKEHKLKKGAGYHLDL  V ++
Sbjct: 726  VPPFGENPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAIL 785

Query: 962  LGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMGL 1021
            + +CS+M LPW+VAATV+SI+H++SLK+E+E SAPGEQPKFLG+REQRVTG ++FIL GL
Sbjct: 786  MVICSLMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGL 845

Query: 1022 SVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLWK 1081
            SVFM  +LKFIPMPVLYGVFLYMGV+SL G+Q  DR+KL  MP KHQPD IYLR+VPL +
Sbjct: 846  SVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRR 905

Query: 1082 VHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPES 1141
            VH+FT +Q+ CL LLW++K + AA++FP+M+LALV VRK MD  F++ +LS+LDD++PE 
Sbjct: 906  VHLFTFLQVLCLALLWILKSTVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEK 965

Query: 1142 KKKKEDDKKKKEKEEAERMLQDDDDTVHLPF-EGGSLLQIPVKALKYSP 1189
             KKK++D+KKK+K++    L  D+D    P+ E    ++IP+  ++  P
Sbjct: 966  DKKKKEDEKKKKKKKGS--LDSDNDDSDCPYSEKVPSIKIPMDIMEQQP 1012



 Score =  167 bits (424), Expect = 4e-41
 Identities = 89/186 (47%), Positives = 123/186 (66%), Gaps = 9/186 (4%)

Query: 91  SQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWS 150
           ++R++FILG EDD     P  LFTE+DEL   DG+E EWKETARW+KFEE VE GG+RWS
Sbjct: 45  AERIRFILGEEDDSPA--PPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWS 102

Query: 151 KPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDESIRENVRE 210
           KP+VATLSLHSLFELR+C+  G++MLD  AS+L ++ +M++D+ I +G L   +++ V  
Sbjct: 103 KPHVATLSLHSLFELRTCMEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTY 162

Query: 211 ALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGE-GLSASRHSLRTGLSASN 269
            LL++H HQ +K        +RS ADIGK  S    +  N + G  A  H   T  S ++
Sbjct: 163 TLLRKHRHQTKK------SNLRSLADIGKTVSSASRMFTNPDNGSPAMTHRNLTSSSLND 216

Query: 270 LSLRGE 275
           +S + E
Sbjct: 217 ISDKPE 222


>gi|148596928 solute carrier family 4, sodium bicarbonate
            cotransporter, member 4 isoform 1 [Homo sapiens]
          Length = 1079

 Score =  910 bits (2353), Expect = 0.0
 Identities = 466/829 (56%), Positives = 592/829 (71%), Gaps = 35/829 (4%)

Query: 379  SPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDF 438
            SP     NL +S   +I         +N           FM+K+P  AEASNVLVGEVDF
Sbjct: 245  SPAMTHRNLTSSSLNDISDKPEKDQLKNK----------FMKKLPRDAEASNVLVGEVDF 294

Query: 439  LERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQYHEIGRSIATLMTDEIFH 498
            L+ P IAFVRL  AV+L  LTEVPVPTRFLF+LLGP GKA  YHEIGR+IATLM+DE+FH
Sbjct: 295  LDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFH 354

Query: 499  DVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPVFHNGSTP 558
            D+AYKAKDR+DL++GIDEFLD+V VLPPGEWDP+IRIEPPKS+PS +KRK       +  
Sbjct: 355  DIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQ 414

Query: 559  TLGETPKEAAHHAG-----PELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASIL 613
              G+TP +  H  G      ELQRTGR  GGLI DIKRKAPFF SDF DAL++Q L++IL
Sbjct: 415  MNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAIL 474

Query: 614  FLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLV 673
            F+Y A ++  ITFGGLLG+AT+     +ES  G +++G  + LFAGQPLTIL STGPVLV
Sbjct: 475  FIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLV 534

Query: 674  FEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICI 733
            FE++L+ F +D    YL  R  IGLW++FLC++LVATDAS LV Y TRFTEE F++LI  
Sbjct: 535  FERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISF 594

Query: 734  IFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSN------ETLAQWKKDNI 787
            IFIY+A +K+  L + Y  N +  +   T +SC C  PP+P+N       TLA      +
Sbjct: 595  IFIYDAFKKMIKLADYYPINSNFKVGYNTLFSCTCV-PPDPANISISNDTTLAPEYLPTM 653

Query: 788  TA----HNIS--WRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSSF 841
            ++    HN +  W  L+  EC K  G  +G+ C     ++PD+     ILF  T+  S  
Sbjct: 654  SSTDMYHNTTFDWAFLSKKECSKYGGNLVGNNCN----FVPDITLMSFILFLGTYTSSMA 709

Query: 842  LKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGWI 901
            LK+FKT  YFPT  R  ISDFA+ L+I+I   ID LVGV +PKL VP +F+PT P RGW 
Sbjct: 710  LKKFKTSPYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWF 769

Query: 902  ISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVM 961
            + P G+NPWW  L AAIPALL TILIFMDQQITAVI+NRKEHKLKKGAGYHLDL  V ++
Sbjct: 770  VPPFGENPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAIL 829

Query: 962  LGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMGL 1021
            + +CS+M LPW+VAATV+SI+H++SLK+E+E SAPGEQPKFLG+REQRVTG ++FIL GL
Sbjct: 830  MVICSLMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGL 889

Query: 1022 SVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLWK 1081
            SVFM  +LKFIPMPVLYGVFLYMGV+SL G+Q  DR+KL  MP KHQPD IYLR+VPL +
Sbjct: 890  SVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRR 949

Query: 1082 VHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPES 1141
            VH+FT +Q+ CL LLW++K + AA++FP+M+LALV VRK MD  F++ +LS+LDD++PE 
Sbjct: 950  VHLFTFLQVLCLALLWILKSTVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEK 1009

Query: 1142 KKKKEDDKKKKEKEEAERMLQDDDDTVHLPF-EGGSLLQIPVKALKYSP 1189
             KKK++D+KKK+K++    L  D+D    P+ E    ++IP+  ++  P
Sbjct: 1010 DKKKKEDEKKKKKKKGS--LDSDNDDSDCPYSEKVPSIKIPMDIMEQQP 1056



 Score =  209 bits (532), Expect = 1e-53
 Identities = 121/275 (44%), Positives = 169/275 (61%), Gaps = 23/275 (8%)

Query: 14  DEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVPFSKESRRRHRHR-GHKHHHRRRK 72
           ++EAV+D G  +S +    ++EE+E H  +YIGVHVP S   RRRH+ + GHK    + +
Sbjct: 2   EDEAVLDRG--ASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKTGHKEKKEKER 59

Query: 73  DKE-----SDKEDGRES------PSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELCY 121
             E     SD E+  ES      P     ++R++FILG EDD     P  LFTE+DEL  
Sbjct: 60  ISENYSDKSDIENADESSSSILKPLISPAAERIRFILGEEDDSPA--PPQLFTELDELLA 117

Query: 122 RDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRAS 181
            DG+E EWKETARW+KFEE VE GG+RWSKP+VATLSLHSLFELR+C+  G++MLD  AS
Sbjct: 118 VDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREAS 177

Query: 182 TLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKH 241
           +L ++ +M++D+ I +G L   +++ V   LL++H HQ +K        +RS ADIGK  
Sbjct: 178 SLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKK------SNLRSLADIGKTV 231

Query: 242 SDPHLLERNGE-GLSASRHSLRTGLSASNLSLRGE 275
           S    +  N + G  A  H   T  S +++S + E
Sbjct: 232 SSASRMFTNPDNGSPAMTHRNLTSSSLNDISDKPE 266


>gi|197927160 solute carrier family 4, sodium bicarbonate
            cotransporter, member 4 isoform 3 [Homo sapiens]
          Length = 1094

 Score =  909 bits (2349), Expect = 0.0
 Identities = 461/808 (57%), Positives = 582/808 (72%), Gaps = 32/808 (3%)

Query: 379  SPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDF 438
            SP     NL +S   +I         +N           FM+K+P  AEASNVLVGEVDF
Sbjct: 245  SPAMTHRNLTSSSLNDISDKPEKDQLKNK----------FMKKLPRDAEASNVLVGEVDF 294

Query: 439  LERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQYHEIGRSIATLMTDEIFH 498
            L+ P IAFVRL  AV+L  LTEVPVPTRFLF+LLGP GKA  YHEIGR+IATLM+DE+FH
Sbjct: 295  LDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFH 354

Query: 499  DVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPVFHNGSTP 558
            D+AYKAKDR+DL++GIDEFLD+V VLPPGEWDP+IRIEPPKS+PS +KRK       +  
Sbjct: 355  DIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQ 414

Query: 559  TLGETPKEAAHHAG-----PELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASIL 613
              G+TP +  H  G      ELQRTGR  GGLI DIKRKAPFF SDF DAL++Q L++IL
Sbjct: 415  MNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAIL 474

Query: 614  FLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLV 673
            F+Y A ++  ITFGGLLG+AT+     +ES  G +++G  + LFAGQPLTIL STGPVLV
Sbjct: 475  FIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLV 534

Query: 674  FEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICI 733
            FE++L+ F +D    YL  R  IGLW++FLC++LVATDAS LV Y TRFTEE F++LI  
Sbjct: 535  FERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISF 594

Query: 734  IFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSN------ETLAQWKKDNI 787
            IFIY+A +K+  L + Y  N +  +   T +SC C  PP+P+N       TLA      +
Sbjct: 595  IFIYDAFKKMIKLADYYPINSNFKVGYNTLFSCTCV-PPDPANISISNDTTLAPEYLPTM 653

Query: 788  TA----HNIS--WRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSSF 841
            ++    HN +  W  L+  EC K  G  +G+ C     ++PD+     ILF  T+  S  
Sbjct: 654  SSTDMYHNTTFDWAFLSKKECSKYGGNLVGNNCN----FVPDITLMSFILFLGTYTSSMA 709

Query: 842  LKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGWI 901
            LK+FKT  YFPT  R  ISDFA+ L+I+I   ID LVGV +PKL VP +F+PT P RGW 
Sbjct: 710  LKKFKTSPYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWF 769

Query: 902  ISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVM 961
            + P G+NPWW  L AAIPALL TILIFMDQQITAVI+NRKEHKLKKGAGYHLDL  V ++
Sbjct: 770  VPPFGENPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAIL 829

Query: 962  LGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMGL 1021
            + +CS+M LPW+VAATV+SI+H++SLK+E+E SAPGEQPKFLG+REQRVTG ++FIL GL
Sbjct: 830  MVICSLMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGL 889

Query: 1022 SVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLWK 1081
            SVFM  +LKFIPMPVLYGVFLYMGV+SL G+Q  DR+KL  MP KHQPD IYLR+VPL +
Sbjct: 890  SVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRR 949

Query: 1082 VHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPES 1141
            VH+FT +Q+ CL LLW++K + AA++FP+M+LALV VRK MD  F++ +LS+LDD++PE 
Sbjct: 950  VHLFTFLQVLCLALLWILKSTVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEK 1009

Query: 1142 KKKKEDDKKKKEKEEAERMLQDDDDTVH 1169
             KKK++D+KKK+K++      +DD+  H
Sbjct: 1010 DKKKKEDEKKKKKKKGSLDSDNDDEKDH 1037



 Score =  209 bits (532), Expect = 1e-53
 Identities = 121/275 (44%), Positives = 169/275 (61%), Gaps = 23/275 (8%)

Query: 14  DEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVPFSKESRRRHRHR-GHKHHHRRRK 72
           ++EAV+D G  +S +    ++EE+E H  +YIGVHVP S   RRRH+ + GHK    + +
Sbjct: 2   EDEAVLDRG--ASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKTGHKEKKEKER 59

Query: 73  DKE-----SDKEDGRES------PSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELCY 121
             E     SD E+  ES      P     ++R++FILG EDD     P  LFTE+DEL  
Sbjct: 60  ISENYSDKSDIENADESSSSILKPLISPAAERIRFILGEEDDSPA--PPQLFTELDELLA 117

Query: 122 RDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRAS 181
            DG+E EWKETARW+KFEE VE GG+RWSKP+VATLSLHSLFELR+C+  G++MLD  AS
Sbjct: 118 VDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREAS 177

Query: 182 TLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKH 241
           +L ++ +M++D+ I +G L   +++ V   LL++H HQ +K        +RS ADIGK  
Sbjct: 178 SLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKK------SNLRSLADIGKTV 231

Query: 242 SDPHLLERNGE-GLSASRHSLRTGLSASNLSLRGE 275
           S    +  N + G  A  H   T  S +++S + E
Sbjct: 232 SSASRMFTNPDNGSPAMTHRNLTSSSLNDISDKPE 266


>gi|19743827 sodium bicarbonate transporter 4 isoform c [Homo sapiens]
          Length = 1121

 Score =  831 bits (2146), Expect = 0.0
 Identities = 419/826 (50%), Positives = 572/826 (69%), Gaps = 63/826 (7%)

Query: 418  FMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGK 477
            FM+KIP  +EASNVLVGEVDFL++P IAFVRL  + +L G+TEVPVPTRFLF+LLGP+G+
Sbjct: 294  FMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGR 353

Query: 478  APQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEP 537
            A  Y+EIGR+IATLM D++F DVAYKA++R DL++GIDEFLD+V VLPPGEWDP+IRIEP
Sbjct: 354  AKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEP 413

Query: 538  PKSVPSQEKRKIPVFH-------NGSTPTLGETP-------------------------- 564
            PK VPS +KRK  VF        NGS    G  P                          
Sbjct: 414  PKKVPSADKRK-SVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSS 472

Query: 565  -----KEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCAC 619
                   A H  G EL  TGR FGGL LDIKRK P+F SDF D   +Q +++ILF+Y  C
Sbjct: 473  GDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGC 532

Query: 620  MSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILY 679
            ++  ITFGGLLG+AT+     +ES  G ++ G  + LF+GQPL IL STGP+L+FEK+L+
Sbjct: 533  ITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLF 592

Query: 680  KFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEA 739
             F +   L Y+  R  IGL ++  C++LVATDAS ++ YITRFTEE F+ LI  IFIY+A
Sbjct: 593  DFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDA 652

Query: 740  LEKLFDLGETYAFNMHNNLDKLTSYSCVCTEP------------PNPSNETLAQWKKDNI 787
            ++K+    + Y  NM    + +T+Y C C  P            P   +   + +   N+
Sbjct: 653  IKKMIGAFKYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNL 712

Query: 788  TAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSSFLKQFKT 847
            TA  + W  L+  EC    G  LG++C     +IPD+     ILFF T+ ++  LK+FK 
Sbjct: 713  TA--LDWSLLSKKECLSYGGRLLGNSC----KFIPDLALMSFILFFGTYSMTLTLKKFKF 766

Query: 848  KRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGWIISPLGD 907
             RYFPTKVR+ ++DF++  +I++   ID   G+ +PKLHVP   +PT P+RGW ++P G 
Sbjct: 767  SRYFPTKVRALVADFSIVFSILMFCGIDACFGLETPKLHVPSVIKPTRPDRGWFVAPFGK 826

Query: 908  NPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSV 967
            NPWW    + +PALL TILIFMDQQITAVI+NRKE+KLKK AGYHLDL  VG+++ +CS 
Sbjct: 827  NPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSF 886

Query: 968  MGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMGLSVFMTS 1027
            MGLPW+VAATV+SI+H++SLK+E+E SAPGEQP+FLG+REQRVTG+++FIL G+SVF+  
Sbjct: 887  MGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAP 946

Query: 1028 VLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTV 1087
            +LK IP+PVLYGVFLYMGV+SL GIQ ++R KLF MPAKHQPD  +LR+VPL ++H+FT+
Sbjct: 947  ILKCIPLPVLYGVFLYMGVASLNGIQFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTL 1006

Query: 1088 IQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPESKKKKED 1147
            +Q+ CL +LW++K + AA++FP+M+L L+ VR+L+D  F++ +L+W+D+++PE K+KKE 
Sbjct: 1007 VQILCLAVLWILKSTVAAIIFPVMILGLIIVRRLLDFIFSQHDLAWIDNILPE-KEKKET 1065

Query: 1148 DKKKKEKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALKYSPDKPV 1193
            DKK+K K+ A    +D D+    P    S+++IP+++++  P   +
Sbjct: 1066 DKKRKRKKGAH---EDCDEEPQFP--PPSVIKIPMESVQSDPQNGI 1106



 Score =  154 bits (389), Expect = 5e-37
 Identities = 96/235 (40%), Positives = 132/235 (56%), Gaps = 30/235 (12%)

Query: 43  VYIGVHVPFSKESRRRHRHRGH-----KHHHRRRKDKESDKEDGRESPSYDTPS------ 91
           ++IG+ VP   +  R+   +GH     K H   R D+   +  G  S +    S      
Sbjct: 31  IHIGLPVPTYPQ--RKTDQKGHLSGLQKVHWGLRPDQPQQELTGPGSGASSQDSSMDLIS 88

Query: 92  -------QRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVED 144
                  +++Q ILG ED+        LFTEMD L + DG++ EWKE+ARW+KFEE VE+
Sbjct: 89  RTRSPAAEQLQDILGEEDEAPNPT---LFTEMDTLQH-DGDQMEWKESARWIKFEEKVEE 144

Query: 145 GGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDESI 204
           GG+RWSKP+V+TLSLHSLFELR+C+  GTV+LD+ + +L +I D V++  I  G L   +
Sbjct: 145 GGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPEL 204

Query: 205 RENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGLSASRH 259
           RE V   LL+RH HQ +K      P+ RS ADIGK  S  +       G   S H
Sbjct: 205 RERVSYVLLRRHRHQTKK------PIHRSLADIGKSVSTTNRSPARSPGAGPSLH 253


>gi|125987596 sodium bicarbonate transporter 4 isoform a [Homo
            sapiens]
          Length = 1137

 Score =  821 bits (2121), Expect = 0.0
 Identities = 419/842 (49%), Positives = 573/842 (68%), Gaps = 79/842 (9%)

Query: 418  FMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGK 477
            FM+KIP  +EASNVLVGEVDFL++P IAFVRL  + +L G+TEVPVPTRFLF+LLGP+G+
Sbjct: 294  FMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGR 353

Query: 478  APQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEP 537
            A  Y+EIGR+IATLM D++F DVAYKA++R DL++GIDEFLD+V VLPPGEWDP+IRIEP
Sbjct: 354  AKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEP 413

Query: 538  PKSVPSQEKRKIPVFH-------NGSTPTLGETP-------------------------- 564
            PK VPS +KRK  VF        NGS    G  P                          
Sbjct: 414  PKKVPSADKRK-SVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSS 472

Query: 565  -----KEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCAC 619
                   A H  G EL  TGR FGGL LDIKRK P+F SDF D   +Q +++ILF+Y  C
Sbjct: 473  GDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGC 532

Query: 620  MSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILY 679
            ++  ITFGGLLG+AT+     +ES  G ++ G  + LF+GQPL IL STGP+L+FEK+L+
Sbjct: 533  ITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLF 592

Query: 680  KFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEA 739
             F +   L Y+  R  IGL ++  C++LVATDAS ++ YITRFTEE F+ LI  IFIY+A
Sbjct: 593  DFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDA 652

Query: 740  LEKLFDLGETYAFNMHNNLDKLTSYSCVCTEP------------PNPSNETLAQWKKDNI 787
            ++K+    + Y  NM    + +T+Y C C  P            P   +   + +   N+
Sbjct: 653  IKKMIGAFKYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNL 712

Query: 788  TAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSSFLKQFKT 847
            TA  + W  L+  EC    G  LG++C     +IPD+     ILFF T+ ++  LK+FK 
Sbjct: 713  TA--LDWSLLSKKECLSYGGRLLGNSC----KFIPDLALMSFILFFGTYSMTLTLKKFKF 766

Query: 848  KRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGWIISPLGD 907
             RYFPTKVR+ ++DF++  +I++   ID   G+ +PKLHVP   +PT P+RGW ++P G 
Sbjct: 767  SRYFPTKVRALVADFSIVFSILMFCGIDACFGLETPKLHVPSVIKPTRPDRGWFVAPFGK 826

Query: 908  NPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSV 967
            NPWW    + +PALL TILIFMDQQITAVI+NRKE+KLKK AGYHLDL  VG+++ +CS 
Sbjct: 827  NPWWVYPASILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSF 886

Query: 968  MGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMGLSVFMTS 1027
            MGLPW+VAATV+SI+H++SLK+E+E SAPGEQP+FLG+REQRVTG+++FIL G+SVF+  
Sbjct: 887  MGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAP 946

Query: 1028 VLKFIPMPVLYGVFLYMGVSSLKGIQL----------------FDRIKLFGMPAKHQPDL 1071
            +LK IP+PVLYGVFLYMGV+SL GIQ+                ++R KLF MPAKHQPD 
Sbjct: 947  ILKCIPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDH 1006

Query: 1072 IYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKREL 1131
             +LR+VPL ++H+FT++Q+ CL +LW++K + AA++FP+M+L L+ VR+L+D  F++ +L
Sbjct: 1007 AFLRHVPLRRIHLFTLVQILCLAVLWILKSTVAAIIFPVMILGLIIVRRLLDFIFSQHDL 1066

Query: 1132 SWLDDLMPESKKKKEDDKKKKEKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALKYSPDK 1191
            +W+D+++PE K+KKE DKK+K K+ A    +D D+    P    S+++IP+++++  P  
Sbjct: 1067 AWIDNILPE-KEKKETDKKRKRKKGAH---EDCDEEPQFP--PPSVIKIPMESVQSDPQN 1120

Query: 1192 PV 1193
             +
Sbjct: 1121 GI 1122



 Score =  154 bits (389), Expect = 5e-37
 Identities = 96/235 (40%), Positives = 132/235 (56%), Gaps = 30/235 (12%)

Query: 43  VYIGVHVPFSKESRRRHRHRGH-----KHHHRRRKDKESDKEDGRESPSYDTPS------ 91
           ++IG+ VP   +  R+   +GH     K H   R D+   +  G  S +    S      
Sbjct: 31  IHIGLPVPTYPQ--RKTDQKGHLSGLQKVHWGLRPDQPQQELTGPGSGASSQDSSMDLIS 88

Query: 92  -------QRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVED 144
                  +++Q ILG ED+        LFTEMD L + DG++ EWKE+ARW+KFEE VE+
Sbjct: 89  RTRSPAAEQLQDILGEEDEAPNPT---LFTEMDTLQH-DGDQMEWKESARWIKFEEKVEE 144

Query: 145 GGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDESI 204
           GG+RWSKP+V+TLSLHSLFELR+C+  GTV+LD+ + +L +I D V++  I  G L   +
Sbjct: 145 GGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPEL 204

Query: 205 RENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGLSASRH 259
           RE V   LL+RH HQ +K      P+ RS ADIGK  S  +       G   S H
Sbjct: 205 RERVSYVLLRRHRHQTKK------PIHRSLADIGKSVSTTNRSPARSPGAGPSLH 253


>gi|151101449 solute carrier family 4, sodium bicarbonate
            cotransporter, member 9 [Homo sapiens]
          Length = 959

 Score =  745 bits (1923), Expect = 0.0
 Identities = 385/765 (50%), Positives = 523/765 (68%), Gaps = 32/765 (4%)

Query: 420  RKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAP 479
            +K+P GAEA  VL GE+ FL +P+ AFVRL   V+L  LTEV +P+RF  LLLGP     
Sbjct: 194  QKLPPGAEAGTVLAGELGFLAQPLGAFVRLRNPVVLGSLTEVSLPSRFFCLLLGPCMLGK 253

Query: 480  QYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPK 539
             YHE+GR+ A L++D  F     +A + +DLL+ +D FL++VTVLPPG WDP+ RI PPK
Sbjct: 254  GYHEMGRAAAVLLSDPQFQWSVRRASNLHDLLAALDAFLEEVTVLPPGRWDPTARIPPPK 313

Query: 540  SVPSQEKRKIPVFHNGSTPTLGE-TPKEAAHHAGP-----ELQRTGRLFGGLILDIKRKA 593
             +PSQ KR          P +   T  E  H  GP     ELQRTGRLFGGLI D++RK 
Sbjct: 314  CLPSQHKRLPSQQREIRGPAVPRLTSAEDRHRHGPHAHSPELQRTGRLFGGLIQDVRRKV 373

Query: 594  PFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIA 653
            P++ SDF DAL LQC +++L++Y A ++  ITFGGLLG+AT+G    +ES  G ++ G A
Sbjct: 374  PWYPSDFLDALHLQCFSAVLYIYLATVTNAITFGGLLGDATDGAQGVLESFLGTAVAGAA 433

Query: 654  YSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDAS 713
            + L AGQPLTIL STGPVLVFE++L+ F RDY L YL  R  +G+W +  C+VLVAT+AS
Sbjct: 434  FCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVATFCLVLVATEAS 493

Query: 714  SLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPN 773
             LV Y TRFTEE F ALI +IFIY+A+ K+ +L  TY      +    ++Y C+C  P  
Sbjct: 494  VLVRYFTRFTEEGFCALISLIFIYDAVGKMLNLTHTYPIQKPGS----SAYGCLCQYPGP 549

Query: 774  PSNETLAQW------KKDNITAHNISWRNLTV---SECKKLRGVFLGSACGHHGPYIPDV 824
              NE+  QW       +D+I + ++   N ++    EC +  G   G  C      +PD+
Sbjct: 550  GGNES--QWIRTRPKDRDDIVSMDLGLINASLLPPPECTRQGGHPRGPGCHT----VPDI 603

Query: 825  LFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPK 884
             F+ ++LF T+FF +  LK  KT R+FP+ VR  +SDF+  L I++   +D  +G+ +PK
Sbjct: 604  AFFSLLLFLTSFFFAMALKCVKTSRFFPSVVRKGLSDFSSVLAILLGCGLDAFLGLATPK 663

Query: 885  LHVPEKFEPTHPERGWIISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHK 944
            L VP +F+PT P RGW++SP G NPWW  + AA+PALL +ILIFMDQQITAVI+NR E++
Sbjct: 664  LMVPREFKPTLPGRGWLVSPFGANPWWWSVAAALPALLLSILIFMDQQITAVILNRMEYR 723

Query: 945  LKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLG 1004
            L+KGAG+HLDL  V V++ + S +GLPW+V+ATV+S++H++SL+ ES   APGE+P FLG
Sbjct: 724  LQKGAGFHLDLFCVAVLMLLTSALGLPWYVSATVISLAHMDSLRRESRACAPGERPNFLG 783

Query: 1005 IREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMP 1064
            IREQR+TGL++FIL G S+F+  VLKFIPMPVLYG+FLYMGV++L  IQ  +R+KL  MP
Sbjct: 784  IREQRLTGLVVFILTGASIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFTNRVKLLLMP 843

Query: 1065 AKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDL 1124
            AKHQPDL+ LR+VPL +VH+FT IQL CL LLW+IK + AA++FP+M+L LV VRK ++ 
Sbjct: 844  AKHQPDLLLLRHVPLTRVHLFTAIQLACLGLLWIIKSTPAAIIFPLMLLGLVGVRKALER 903

Query: 1125 CFTKRELSWLDDLMPESKK-------KKEDDKKKKEKEEAERMLQ 1162
             F+ +EL WLD+LMPE ++       + E      + E++E M Q
Sbjct: 904  VFSPQELLWLDELMPEEERSIPEKGLEPEHSFSGSDSEDSELMYQ 948



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 51/142 (35%), Positives = 71/142 (50%), Gaps = 11/142 (7%)

Query: 80  DGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFE 139
           D    PS D PS      LG   D        LF +++EL     +  EW+ET RW+ FE
Sbjct: 30  DPGTGPSPDGPSDTESKELGVPKDPL------LFIQLNELLGWP-QALEWRETGRWVLFE 82

Query: 140 EDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQ 199
           E +E    RWS P+V TL+L SL +LRS +  G V+LD  A +L E+ + V         
Sbjct: 83  EKLEVAAGRWSAPHVPTLALPSLQKLRSLLAEGLVLLDCPAQSLLELVEQV----TRVES 138

Query: 200 LDESIRENVREALLKRHHHQNE 221
           L   +R  ++  LL+R  H N+
Sbjct: 139 LSPELRGQLQALLLQRPQHYNQ 160


>gi|156071474 solute carrier family 4, anion exchanger, member 2
            (erythrocyte membrane protein band 3-like 1) [Homo
            sapiens]
          Length = 1241

 Score =  568 bits (1463), Expect = e-161
 Identities = 317/743 (42%), Positives = 447/743 (60%), Gaps = 44/743 (5%)

Query: 412  SKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLL 471
            SK ++  + KIP  AEA+ VLVG V+FL RP +AFVRL  AV L  + EVPVP RFLFLL
Sbjct: 500  SKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLL 559

Query: 472  LGPAGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDP 531
            LGP+     YHEIGRSI+TLM+D+ FH+ AY A +R DLL+ I+ FLD   VLPP E   
Sbjct: 560  LGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQG 619

Query: 532  SIRIEPPKSVPSQEKRKIPVFHNGSTPTLGETPKEAAHHA------------GPELQRTG 579
               +        Q  +K            G  PK A   A               L+RTG
Sbjct: 620  EELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTG 679

Query: 580  RLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRIS 639
            R FGGLI D++R+ P +LSDF+DAL  QCLA+++F+Y A +SP ITFGGLLGE T+  I 
Sbjct: 680  RPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIG 739

Query: 640  AIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLW 699
              E +   +L G+ + L   QPL ++G +GP+LVFE+  + FC    L YL  R  IG W
Sbjct: 740  VSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFW 799

Query: 700  TSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLD 759
              FL +++VA + S LV +++RFT+E FA LI +IFIYE   KL  +     F  H    
Sbjct: 800  LVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKI-----FQEH---- 850

Query: 760  KLTSYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGP 819
                          P +   A    +     N++W     +     R   L    G   P
Sbjct: 851  --------------PLHGCSASNSSEVDGGENMTWAGARPTLGPGNRS--LAGQSGQGKP 894

Query: 820  Y-IPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLV 878
               P+     ++L   TFF++ FL++FK  R+FP ++R  I DF V + I+IMV +DY +
Sbjct: 895  RGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSI 954

Query: 879  -GVPSPKLHVPEKFEPTHPE-RGWIISPLGDN---PWWTLLIAAIPALLCTILIFMDQQI 933
                + KL VP  F  T PE RGW+I+PLG+    P W ++ + +PA+L  ILIFM+ QI
Sbjct: 955  EDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQI 1014

Query: 934  TAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESEC 993
            T +II++KE  L+KG+G+HLDLL++  M G+C++ GLPW  AATV S++H N+L V S+ 
Sbjct: 1015 TTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKA 1074

Query: 994  SAPGEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQ 1053
             APG++PK   ++EQRVTGL++ +L+GLS+ +  +L+ IP+ VL+G+FLYMGV+SL GIQ
Sbjct: 1075 VAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQ 1134

Query: 1054 LFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVL 1113
             ++R+ L  MP KH PD+ Y++ V   ++H+FT +QL CL LLW +  +AA++ FP +++
Sbjct: 1135 FYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILI 1194

Query: 1114 ALVFVRK-LMDLCFTKRELSWLD 1135
              V +R  ++   FT RE+  LD
Sbjct: 1195 LTVPLRMVVLTRIFTDREMKCLD 1217



 Score =  122 bits (307), Expect = 2e-27
 Identities = 73/200 (36%), Positives = 108/200 (54%), Gaps = 18/200 (9%)

Query: 68  HRRRKDKESDKEDGRESPSYD-TPSQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEE 126
           H  RK+ +   + GRE      TP  R +           H PH++F E++EL     +E
Sbjct: 287 HLVRKNAKGSTQSGREGREPGPTPRARPR---------APHKPHEVFVELNELLLDKNQE 337

Query: 127 YEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEI 186
            +W+ETARW+KFEEDVE+  +RW KP+VA+LS  SL ELR  + +G V+LD+   TL  +
Sbjct: 338 PQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGV 397

Query: 187 ADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKR---FTSRIPLVRSFADIGKKH-- 241
           A  V++ M+ S Q+    R NV  ALL +H H ++++   F   I      + +G  H  
Sbjct: 398 AHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQ 457

Query: 242 ---SDPHLLERNGEGLSASR 258
              SDPH+ E    G+  +R
Sbjct: 458 GAESDPHVTEPLMGGVPETR 477


>gi|157671951 solute carrier family 4, anion exchanger, member 3
            isoform 1 [Homo sapiens]
          Length = 1232

 Score =  561 bits (1445), Expect = e-159
 Identities = 321/755 (42%), Positives = 455/755 (60%), Gaps = 55/755 (7%)

Query: 416  MNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPA 475
            +  + KIP  AEA+ VLVG V FLE+P  AFVRL  AVLL  + EVPVP RFLF++LGP+
Sbjct: 503  LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPS 562

Query: 476  GKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWD----- 530
              +  YHE+GRSIATLM+D++FH+ AY+A DR DLLS I EFLD   V+PP E +     
Sbjct: 563  HTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLL 622

Query: 531  ---PSIRIEPPKSVPSQEKRKIPVFHNGSTPTLGE--TPKEAAHHAGPE---LQRTGRLF 582
                + + E  +    +E+ K+ +   G     G+  + +     A PE   L RTG +F
Sbjct: 623  RSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVF 682

Query: 583  GGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIE 642
            GGL+ D++R+ P + SD +DAL  QC+A++LF+Y A +SP ITFGGLLGE TEG +   E
Sbjct: 683  GGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSE 742

Query: 643  SLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSF 702
             +   ++ G+ +SL   QPL ++G +GP+LVFE+  +KFCR   L YL+ R  +GLW   
Sbjct: 743  LIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVV 802

Query: 703  LCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLT 762
              + LVA + S LV YI+ FT+E FA LI +IFIYE   KL+ +               T
Sbjct: 803  FVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKV--------------FT 848

Query: 763  SYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGP-YI 821
             +  +   PP  + E                    ++    +  G  L    G   P   
Sbjct: 849  EHPLLPFYPPEGALEG-------------------SLDAGLEPNGSALPPTEGPPSPRNQ 889

Query: 822  PDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDY-LVGV 880
            P+     +IL   TFF++ FL++F+  R+   K R  I DF + ++I++MV +DY +   
Sbjct: 890  PNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDT 949

Query: 881  PSPKLHVPEKFEPTHPE-RGWIISPLGDN---PWWTLLIAAIPALLCTILIFMDQQITAV 936
             + KL VP     T P+ R W I PLG     P W ++ AA+PALL  ILIFM+ QITA+
Sbjct: 950  YTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITAL 1009

Query: 937  IINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAP 996
            I+++K  +L KG+G+HLDLL++G + G+C + GLPW  AATV S++HVN+L V     AP
Sbjct: 1010 IVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAP 1069

Query: 997  GEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFD 1056
            G++P+   +REQRVTG++I  L+GLS+ M +VL+ IP+ VL+G+FLYMGV+SL GIQL  
Sbjct: 1070 GDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQ 1129

Query: 1057 RIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALV 1116
            R+ L  MPAKH P+  Y+  V  W++H+FT IQL C+ LLWV+K +AA++ FP ++L  V
Sbjct: 1130 RLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTV 1189

Query: 1117 FVRK-LMDLCFTKRELSWLD--DLMPESKKKKEDD 1148
             +R  L+   F  REL  LD  D  P   +  +D+
Sbjct: 1190 PLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDE 1224



 Score =  120 bits (301), Expect = 8e-27
 Identities = 72/195 (36%), Positives = 103/195 (52%), Gaps = 8/195 (4%)

Query: 54  ESRRRHRHRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLF 113
           +  + HR   +    R    K S  + GR SPS   P  R +     +    +  PH++F
Sbjct: 267 DDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRK----KKKKKLDRRPHEVF 322

Query: 114 TEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGT 173
            E++EL     +E  W+ETARW+KFEEDVE+  +RW KP+VA+LS  SL ELR  I +G 
Sbjct: 323 VELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGA 382

Query: 174 VMLDMRASTLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKR---FTSRIPL 230
            +LD+  +TL  IA +V++ MI S Q+    R +V   LL +H H N+ +   F  R P 
Sbjct: 383 ALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPS 442

Query: 231 VRSFADI-GKKHSDP 244
             S   + G  H  P
Sbjct: 443 SSSMNSVLGNHHPTP 457


>gi|157671953 solute carrier family 4, anion exchanger, member 3
            isoform 2 [Homo sapiens]
          Length = 1259

 Score =  561 bits (1445), Expect = e-159
 Identities = 321/755 (42%), Positives = 455/755 (60%), Gaps = 55/755 (7%)

Query: 416  MNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPA 475
            +  + KIP  AEA+ VLVG V FLE+P  AFVRL  AVLL  + EVPVP RFLF++LGP+
Sbjct: 530  LKLLEKIPEDAEATVVLVGCVPFLEQPAAAFVRLNEAVLLESVLEVPVPVRFLFVMLGPS 589

Query: 476  GKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWD----- 530
              +  YHE+GRSIATLM+D++FH+ AY+A DR DLLS I EFLD   V+PP E +     
Sbjct: 590  HTSTDYHELGRSIATLMSDKLFHEAAYQADDRQDLLSAISEFLDGSIVIPPSEVEGRDLL 649

Query: 531  ---PSIRIEPPKSVPSQEKRKIPVFHNGSTPTLGE--TPKEAAHHAGPE---LQRTGRLF 582
                + + E  +    +E+ K+ +   G     G+  + +     A PE   L RTG +F
Sbjct: 650  RSVAAFQRELLRKRREREQTKVEMTTRGGYTAPGKELSLELGGSEATPEDDPLLRTGSVF 709

Query: 583  GGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIE 642
            GGL+ D++R+ P + SD +DAL  QC+A++LF+Y A +SP ITFGGLLGE TEG +   E
Sbjct: 710  GGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVSE 769

Query: 643  SLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSF 702
             +   ++ G+ +SL   QPL ++G +GP+LVFE+  +KFCR   L YL+ R  +GLW   
Sbjct: 770  LIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVV 829

Query: 703  LCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLT 762
              + LVA + S LV YI+ FT+E FA LI +IFIYE   KL+ +               T
Sbjct: 830  FVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKV--------------FT 875

Query: 763  SYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGP-YI 821
             +  +   PP  + E                    ++    +  G  L    G   P   
Sbjct: 876  EHPLLPFYPPEGALEG-------------------SLDAGLEPNGSALPPTEGPPSPRNQ 916

Query: 822  PDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDY-LVGV 880
            P+     +IL   TFF++ FL++F+  R+   K R  I DF + ++I++MV +DY +   
Sbjct: 917  PNTALLSLILMLGTFFIAFFLRKFRNSRFLGGKARRIIGDFGIPISILVMVLVDYSITDT 976

Query: 881  PSPKLHVPEKFEPTHPE-RGWIISPLGDN---PWWTLLIAAIPALLCTILIFMDQQITAV 936
             + KL VP     T P+ R W I PLG     P W ++ AA+PALL  ILIFM+ QITA+
Sbjct: 977  YTQKLTVPTGLSVTSPDKRSWFIPPLGSARPFPPWMMVAAAVPALLVLILIFMETQITAL 1036

Query: 937  IINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAP 996
            I+++K  +L KG+G+HLDLL++G + G+C + GLPW  AATV S++HVN+L V     AP
Sbjct: 1037 IVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAP 1096

Query: 997  GEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFD 1056
            G++P+   +REQRVTG++I  L+GLS+ M +VL+ IP+ VL+G+FLYMGV+SL GIQL  
Sbjct: 1097 GDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQ 1156

Query: 1057 RIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALV 1116
            R+ L  MPAKH P+  Y+  V  W++H+FT IQL C+ LLWV+K +AA++ FP ++L  V
Sbjct: 1157 RLLLILMPAKHHPEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTV 1216

Query: 1117 FVRK-LMDLCFTKRELSWLD--DLMPESKKKKEDD 1148
             +R  L+   F  REL  LD  D  P   +  +D+
Sbjct: 1217 PLRHCLLPRLFQDRELQALDSEDAEPNFDEDGQDE 1251



 Score =  120 bits (301), Expect = 8e-27
 Identities = 72/195 (36%), Positives = 103/195 (52%), Gaps = 8/195 (4%)

Query: 54  ESRRRHRHRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLF 113
           +  + HR   +    R    K S  + GR SPS   P  R +     +    +  PH++F
Sbjct: 294 DDMKSHRLEDNPGVRRHLVKKPSRTQGGRGSPSGLAPILRRK----KKKKKLDRRPHEVF 349

Query: 114 TEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGT 173
            E++EL     +E  W+ETARW+KFEEDVE+  +RW KP+VA+LS  SL ELR  I +G 
Sbjct: 350 VELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAHGA 409

Query: 174 VMLDMRASTLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKR---FTSRIPL 230
            +LD+  +TL  IA +V++ MI S Q+    R +V   LL +H H N+ +   F  R P 
Sbjct: 410 ALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFPRNPS 469

Query: 231 VRSFADI-GKKHSDP 244
             S   + G  H  P
Sbjct: 470 SSSMNSVLGNHHPTP 484


>gi|4507021 solute carrier family 4, anion exchanger, member 1 [Homo
            sapiens]
          Length = 911

 Score =  510 bits (1313), Expect = e-144
 Identities = 298/781 (38%), Positives = 444/781 (56%), Gaps = 82/781 (10%)

Query: 399  GSGGSRENSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGL 458
            G GG+  +S           + KIP  +EA+ VLVG  DFLE+P++ FVRL  A  L  +
Sbjct: 204  GDGGTEGHSP-------SGILEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAELEAV 256

Query: 459  TEVPVPTRFLFLLLGPAGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFL 518
             E+PVP RFLF+LLGP      Y ++GR+ ATLM++ +F   AY A+ R +LL  ++ FL
Sbjct: 257  -ELPVPIRFLFVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFL 315

Query: 519  DQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPVFHNGSTPTLGETPKEAAHHAGPE--LQ 576
            D   VLPP +      +     VP Q +     + +          K    + GP+  LQ
Sbjct: 316  DCSLVLPPTDAPSEQALL--SLVPVQRELLRRRYQSSPAKPDSSFYKGLDLNGGPDDPLQ 373

Query: 577  RTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEG 636
            +TG+LFGGL+ DI+R+ P++LSD  DA S Q LA+++F+Y A +SP ITFGGLLGE T  
Sbjct: 374  QTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLGEKTRN 433

Query: 637  RISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSI 696
            ++   E L   ++ GI ++L   QPL ++G +GP+LVFE+  + FC    L Y+  R  I
Sbjct: 434  QMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWI 493

Query: 697  GLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHN 756
            G W   L +++VA + S LV +I+R+T+E F+ LI +IFIYE   KL  + + +      
Sbjct: 494  GFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHP----- 548

Query: 757  NLDKLTSYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGH 816
             L K  +Y+ +    P                                            
Sbjct: 549  -LQKTYNYNVLMVPKPQ------------------------------------------- 564

Query: 817  HGPYIPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDY 876
             GP +P+     ++L   TFF +  L++FK   YFP K+R  I DF V ++I+IMV +D+
Sbjct: 565  -GP-LPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDF 622

Query: 877  LV-GVPSPKLHVPEKFEPTHPE-RGWIISPLG---DNPWWTLLIAAIPALLCTILIFMDQ 931
             +    + KL VP+ F+ ++   RGW+I PLG   + P W +  +A+PALL  ILIF++ 
Sbjct: 623  FIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRSEFPIWMMFASALPALLVFILIFLES 682

Query: 932  QITAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVES 991
            QIT +I+++ E K+ KG+G+HLDLL+V  M GV ++ G+PW  A TV S++H N+L V  
Sbjct: 683  QITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMG 742

Query: 992  ECSAPGEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKG 1051
            + S PG   +   ++EQR++GL++ +L+GLS+ M  +L  IP+ VL+G+FLYMGV+SL G
Sbjct: 743  KASTPGAAAQIQEVKEQRISGLLVAVLVGLSILMEPILSRIPLAVLFGIFLYMGVTSLSG 802

Query: 1052 IQLFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMM 1111
            IQLFDRI L   P K+ PD+ Y++ V  W++H+FT IQ+ CL +LWV+K + A++  P +
Sbjct: 803  IQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFV 862

Query: 1112 VLALVFVRK-LMDLCFTKRELSWLDDLMPESKKKKEDDKKKKEKEEAERMLQDDDDTVHL 1170
            ++  V +R+ L+ L F   EL  LD           DD K    EE  R   D+ D V +
Sbjct: 863  LILTVPLRRVLLPLIFRNVELQCLD----------ADDAKATFDEEEGR---DEYDEVAM 909

Query: 1171 P 1171
            P
Sbjct: 910  P 910



 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 40/113 (35%), Positives = 66/113 (58%), Gaps = 2/113 (1%)

Query: 110 HDLFTEMDELCYRD-GEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSC 168
           H ++ E+ EL   +  +E  W E ARW++ EE++ + G  W +P+++ L+  SL ELR  
Sbjct: 55  HKVYVELQELVMDEKNQELRWMEAARWVQLEENLGENG-AWGRPHLSHLTFWSLLELRRV 113

Query: 169 ILNGTVMLDMRASTLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNE 221
              GTV+LD++ ++L  +A+ +LD  I   Q+    RE +  ALL +H H  E
Sbjct: 114 FTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAGE 166


>gi|14042960 solute carrier family 4 member 11 [Homo sapiens]
          Length = 891

 Score =  216 bits (551), Expect = 8e-56
 Identities = 181/675 (26%), Positives = 302/675 (44%), Gaps = 68/675 (10%)

Query: 466  RFLFLLLGPAG--KAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTV 523
            RF+ L+L P          E+ R+ AT+ +D  F     + +   +    +      +T+
Sbjct: 248  RFVILVLAPPKMKSTKTAMEVARTFATMFSDIAFRQKLLETRTEEEFKEALVHQRQLLTM 307

Query: 524  LPPGEWDPSIRIEPPKSVPSQEKRKIPVFHNGSTPTLGETPKEAAHHAGPELQRTGRLFG 583
            +  G   P  +     S+P                        A  H  P   +    FG
Sbjct: 308  VSHGPVAPRTKERSTVSLP------------------------AHRHPEPPKCKDFVPFG 343

Query: 584  -GLILDIKRKAPFFLSDFKDALSLQ------CLASILFLYCACMSPVITFGGLLGEATEG 636
             G+  DI R+ P +  DF D +  +       + + LFLY AC+ P I FG L  E T+G
Sbjct: 344  KGIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLPTIAFGSLNDENTDG 403

Query: 637  RISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSI 696
             I   +++ G S+ G+ Y+LF+GQPL IL +T P+ ++ +++   C DY L + S     
Sbjct: 404  AIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVICDDYDLDFNSFYAWT 463

Query: 697  GLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHN 756
            GLW SF   +    + S ++    R TEE  A  I I F+ +A++    +   Y +  + 
Sbjct: 464  GLWNSFFLALYAFFNLSLVMSLFKRSTEEIIALFISITFVLDAVKGTVKIFWKYYYGHY- 522

Query: 757  NLDKLTSYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKLRGVFLGSAC-- 814
                L  Y    T                ++ + +    +L  S    L   FL S    
Sbjct: 523  ----LDDYHTKRTS---------------SLVSLSGLGASLNASLHTALNASFLASPTEL 563

Query: 815  --GHHGPYIPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMV 872
                H      VL   +++   T +L   L QFK   Y    VR  +SD A+ + ++   
Sbjct: 564  PSATHSGQATAVL--SLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCALPIAVLAFS 621

Query: 873  TIDYLVGVPSPKLHVPEKFEPTHPERGWIISPLGDNPWWTLLIAAIPALLCTILIFMDQQ 932
                L+     +     KF     E  + ++ +       +  A     L ++L F++Q 
Sbjct: 622  ----LISSHGFREIEMSKFRYNPSESPFAMAQIQSLSLRAVSGAMGLGFLLSMLFFIEQN 677

Query: 933  ITAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESE 992
            + A ++N  E++L KG  YH DLL++ ++    S+ GLPW  AA   S  HV +L +  E
Sbjct: 678  LVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEE 737

Query: 993  CSAPGE-QPKFLGIREQRVTGLMIFILMGLSVFMTSV-LKFIPMPVLYGVFLYMGVSSLK 1050
                G      + ++E R+T L   +L+GLS+ +  V L++IP PVLYG+FLY+ ++SL 
Sbjct: 738  RVENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIPKPVLYGLFLYIALTSLD 797

Query: 1051 GIQLFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSA---AAVV 1107
            G QL  R+ L        P   Y+R VP  K+H FT +Q+  L+LL    +S+     ++
Sbjct: 798  GNQLVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQLLLLCAFGMSSLPYMKMI 857

Query: 1108 FPMMVLALVFVRKLM 1122
            FP++++A++ +R ++
Sbjct: 858  FPLIMIAMIPIRYIL 872


>gi|32307128 nuclear receptor coactivator 6 [Homo sapiens]
          Length = 2063

 Score = 41.2 bits (95), Expect = 0.006
 Identities = 32/108 (29%), Positives = 43/108 (39%), Gaps = 11/108 (10%)

Query: 304  PTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALKGEE 363
            P P N+  SSP+ +  T R    S R  P  L SP     P V  HPP + ++  L  +E
Sbjct: 1712 PVPPNALSSSPAPNIQTGRPLVLSSRATPVQLPSPPCTSSPVVPSHPPVQQVK-ELNPDE 1770

Query: 364  QKNEENVDLTPGILASPQS----------APGNLDNSKSGEIKGNGSG 401
               + N       L S QS          +PG+  N +S      G G
Sbjct: 1771 ASPQVNTSADQNTLPSSQSTTMVSPLLTNSPGSSGNRRSPVSSSKGKG 1818



 Score = 33.1 bits (74), Expect = 1.6
 Identities = 44/162 (27%), Positives = 70/162 (43%), Gaps = 38/162 (23%)

Query: 264  GLSASNLSLRGESPLSLLLG---------HLLPSS--RAGTPAGSRCTTPVPTPQNSPPS 312
            GL+ + L   G++P +L +          H L S    +G  + S  T    +P NS  S
Sbjct: 1274 GLNPTTLKAIGQAPSNLTMNPSNFATPQTHKLDSVVVNSGKQSNSGATKRA-SPSNSRRS 1332

Query: 313  SPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALKGEEQKNEENVDL 372
            SP  SR T+ S      +AP+L ++  ++               AAL  +  +   NV +
Sbjct: 1333 SPGSSRKTTPSPGRQNSKAPKLTLASQTN---------------AALL-QNVELPRNVLV 1376

Query: 373  TPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKV 414
            +P  LA+P   PG+  N+         SG + +NSTV  + V
Sbjct: 1377 SPTPLANP-PVPGSFPNN---------SGLNPQNSTVSVAAV 1408



 Score = 32.0 bits (71), Expect = 3.7
 Identities = 25/94 (26%), Positives = 45/94 (47%), Gaps = 9/94 (9%)

Query: 288  SSRAGTPAGSRCTTPVPTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVV 347
            +SR  +P  SR TTP P  QNS     +++  T+ +  ++      +LVSP     P V 
Sbjct: 1328 NSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTNAALLQNVELPRNVLVSPTPLANPPVP 1387

Query: 348  --------IHPPEEDLE-AALKGEEQKNEENVDL 372
                    ++P    +  AA+ G  + N+E++++
Sbjct: 1388 GSFPNNSGLNPQNSTVSVAAVGGVVEDNKESLNV 1421


>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
          Length = 668

 Score = 40.4 bits (93), Expect = 0.010
 Identities = 38/124 (30%), Positives = 54/124 (43%), Gaps = 5/124 (4%)

Query: 205 RENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGL-SASRHSLRT 263
           R+ V   +L RH  +  +R +     V S  D G        +E    G  S S     +
Sbjct: 362 RKRVDSPMLNRHGKRRPERKSME---VLSVTDGGSPVPARRAIEMAQHGQRSRSISGASS 418

Query: 264 GLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCTTPVPTPQNSPPSSPSISRLTSRS 323
           GLS S LS    +P     G  LP+ + GTP  +   +P  TP  +PPSSPS+  +  R+
Sbjct: 419 GLSTSPLSSPRVTPHPSPRGSPLPTPK-GTPVHTPKESPAGTPNPTPPSSPSVGGVPWRA 477

Query: 324 SQES 327
              S
Sbjct: 478 RLNS 481


>gi|9910278 keratinocytes associated transmembrane protein 2 [Homo
           sapiens]
          Length = 265

 Score = 38.1 bits (87), Expect = 0.051
 Identities = 54/225 (24%), Positives = 92/225 (40%), Gaps = 24/225 (10%)

Query: 285 LLPSSRAGTPAGSRCTTPVPTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDI- 343
           LL  S A +   SR  +P PT  NS  S+P+++ LT  +  +         + P +    
Sbjct: 37  LLLVSAALSSVVSRTDSPSPTVLNSHISTPNVNALTHENQTKPSISQISTTLPPTTSTKK 96

Query: 344 ---PTVVIHPPEEDL--EAALKGEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGN 398
               +VV HP    L  E A   E+   EE   L   + +SP +A   LDN   GE   +
Sbjct: 97  SGGASVVPHPSPTPLSQEEADNNEDPSIEEEDLLM--LNSSPSTAKDTLDNGDYGEPDYD 154

Query: 399 GSGGSRE----NSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVL 454
            + G R+    + T++ ++  M   + + +    S+ +  E       +I F      V 
Sbjct: 155 WTTGPRDDDESDDTLEENRGYMEIEQSVKSFKMPSSNIEEEDSHFFFHLIIFAFCIAVVY 214

Query: 455 LTGLTEVPVPTRFLFLLL-------GPAGKAPQYHEIGRSIATLM 492
           +T   +     R +FLL+       G   K  +YH + +++   M
Sbjct: 215 ITYHNK-----RKIFLLVQSRKWRDGLCSKTVEYHRLDQNVNEAM 254


>gi|154354979 myosin X [Homo sapiens]
          Length = 2058

 Score = 37.4 bits (85), Expect = 0.087
 Identities = 30/111 (27%), Positives = 51/111 (45%), Gaps = 8/111 (7%)

Query: 1099 IKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPESKKKKEDDKKKKEKEEAE 1158
            + +  AA+VF   +   +  R    L   KRE         E KK++E++KKK+E+EE E
Sbjct: 786  LHLKKAAIVFQKQLRGQIARRVYRQLLAEKRE-------QEEKKKQEEEEKKKREEEERE 838

Query: 1159 RMLQDDDDTVHLPFEGGSLLQIPVKALKYSPDKPVSVKISFEDEPRKKYVD 1209
            R  +  +  +    E  +  Q  ++AL+ S  K   +    E +   K V+
Sbjct: 839  RERERREAELRAQQEEETRKQQELEALQKS-QKEAELTRELEKQKENKQVE 888


>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
           containing B [Homo sapiens]
          Length = 546

 Score = 37.0 bits (84), Expect = 0.11
 Identities = 22/50 (44%), Positives = 27/50 (54%), Gaps = 3/50 (6%)

Query: 48  HVPFSKESRRRHR--HRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQ 95
           H P  ++SR+R R   R HK  H   KD +SDK D R S S +  SQ  Q
Sbjct: 490 HSPSKEKSRKRSRSKERSHKRDHSDSKD-QSDKHDRRRSQSIEQESQEKQ 538


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 36.6 bits (83), Expect = 0.15
 Identities = 53/210 (25%), Positives = 83/210 (39%), Gaps = 16/210 (7%)

Query: 271  SLRGESPLSLLLGHLLPSSRAGTPAGSRCTTPVPTPQNSPPSSPSISRLTSRSSQESQRQ 330
            S  G +PL++     +PSS  G PA S    P+P P +SP +SP  S ++   S      
Sbjct: 1388 SAPGAAPLTISSPLHVPSSLPG-PASS----PMPIPNSSPLASPVSSTVSVPLSSSLPIS 1442

Query: 331  APELLVSPASDDIPTVVIHPPEEDLEAALKGEEQKNEENVDLTPGILASPQSAPGNLDNS 390
             P  L +PAS  + T+ I  P   L  +  G          L P + A+P   P +L  S
Sbjct: 1443 VPTTLPAPASAPL-TIPISAP---LTVSASGPALLTSVTPPLAPVVPAAP--GPPSLAPS 1496

Query: 391  KSGEIKGNGSGGSRENSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLA 450
             +       + G     ++  S+   + +   PT +      V  ++    P  + V + 
Sbjct: 1497 GASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSH-----VPGLNSTVAPACSPVLVP 1551

Query: 451  PAVLLTGLTEVPVPTRFLFLLLGPAGKAPQ 480
             + L +     P P      LL PA  A Q
Sbjct: 1552 ASALASPFPSAPNPAPAQASLLAPASSASQ 1581


>gi|23308699 transcription factor MAFB [Homo sapiens]
          Length = 323

 Score = 36.2 bits (82), Expect = 0.19
 Identities = 24/73 (32%), Positives = 36/73 (49%), Gaps = 9/73 (12%)

Query: 294 PAGSRCTTPVPTPQNSPPSSPSISRLTSRSSQES--------QRQAPELLVSPASDDIPT 345
           PAGS  +TP+ TP +S PSSPS S    ++  E         Q+  PE L     D +  
Sbjct: 51  PAGSVSSTPLSTPCSSVPSSPSFSPTEQKTHLEDLYWMASNYQQMNPEALNLTPEDAVEA 110

Query: 346 VV-IHPPEEDLEA 357
           ++  HP  + L++
Sbjct: 111 LIGSHPVPQPLQS 123


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 36.2 bits (82), Expect = 0.19
 Identities = 37/134 (27%), Positives = 54/134 (40%), Gaps = 9/134 (6%)

Query: 262  RTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCTTPVPTP------QNSPPSSPS 315
            RT  + +  SL        L G  L S R    A  R +     P        +PPS+PS
Sbjct: 2356 RTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPS 2415

Query: 316  ISRLTS-RSSQESQR--QAPELLVSPASDDIPTVVIHPPEEDLEAALKGEEQKNEENVDL 372
             SR+TS R+   S R  QAP   + P + D P   +     D    L  +      +  L
Sbjct: 2416 QSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSL 2475

Query: 373  TPGILASPQSAPGN 386
            + G +A+  S+ G+
Sbjct: 2476 SSGAVATTTSSAGD 2489


>gi|38176300 nestin [Homo sapiens]
          Length = 1621

 Score = 35.8 bits (81), Expect = 0.25
 Identities = 40/121 (33%), Positives = 56/121 (46%), Gaps = 17/121 (14%)

Query: 290 RAGTPAGSRCTTPVP-TPQNSPPSSPSISR-----LTSRSSQESQRQAPELLVSPASDDI 343
           +A TP  +  +TP+P TPQ   P+  +  R     L+   +Q  ++QAPE L + A   I
Sbjct: 379 QARTP--TLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQGGRKQAPEPLRAEARVAI 436

Query: 344 PTVVIHPPEEDLEAALKGEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGS 403
           P  V+  PEE          Q+ E +   +P   AS   AP    +  S E K   SGGS
Sbjct: 437 PASVLPGPEEP-------GGQRQEASTGQSPEDHAS--LAPPLSPDHSSLEAKDGESGGS 487

Query: 404 R 404
           R
Sbjct: 488 R 488


>gi|22027648 lipin 1 [Homo sapiens]
          Length = 890

 Score = 35.8 bits (81), Expect = 0.25
 Identities = 22/58 (37%), Positives = 34/58 (58%), Gaps = 2/58 (3%)

Query: 279 SLLLGHLLPSSRAGTPAGSRCTTPVPTPQNSPPSSP-SISRLTSRSSQESQRQAPELL 335
           +L L  + P S A  P   R  +P P+P  S PS+P S S L S+S++ + ++ PE+L
Sbjct: 216 NLSLAVIYPQS-ASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEML 272


>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
          Length = 825

 Score = 35.8 bits (81), Expect = 0.25
 Identities = 29/101 (28%), Positives = 43/101 (42%), Gaps = 3/101 (2%)

Query: 275 ESPLSLLLGHLLPSSRAGTPAGSRCTTPVPTPQNSPPSSPSISRLTSRSSQESQRQAPEL 334
           ESP   LL  +LP S   +P+       +P P    PS   +  + S S+Q++  +   L
Sbjct: 340 ESPSVELLAEILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPL 399

Query: 335 LVSPASDDIPTVVIHPPEEDLEA---ALKGEEQKNEENVDL 372
               A ++ P  V  P  E+  A    L  EE   EE  +L
Sbjct: 400 PAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEAREL 440


>gi|13375827 phafin 2 [Homo sapiens]
          Length = 249

 Score = 35.4 bits (80), Expect = 0.33
 Identities = 24/52 (46%), Positives = 28/52 (53%), Gaps = 13/52 (25%)

Query: 632 EATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCR 683
           EA   RIS +E+ FGA          AGQPLTI    G VL+ E +L K CR
Sbjct: 9   EANTRRISIVENCFGA----------AGQPLTI---PGRVLIGEGVLTKLCR 47


>gi|112421108 capicua homolog [Homo sapiens]
          Length = 1608

 Score = 35.4 bits (80), Expect = 0.33
 Identities = 33/140 (23%), Positives = 51/140 (36%), Gaps = 13/140 (9%)

Query: 302  PVPTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALKG 361
            P P P+   P++ S   L   + + +  + PE + S             P    +  + G
Sbjct: 1232 PPPLPETWTPTARSSPPLPPPAEERTSAKGPETMASKF-----------PSSSSDWRVPG 1280

Query: 362  EEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMRK 421
            +  +N       P    +P  APG    S SG   G+         T    KV    ++K
Sbjct: 1281 QGLENRGEPPTPPSPAPAPAVAPGGSSESSSGRAAGDTPERKEAAGTGKKVKVRPPPLKK 1340

Query: 422  IPTGAEASNVLVGEVDFLER 441
              T     N ++ EVDF ER
Sbjct: 1341 --TFDSVDNRVLSEVDFEER 1358


>gi|105554437 forkhead box B1 [Homo sapiens]
          Length = 325

 Score = 35.4 bits (80), Expect = 0.33
 Identities = 40/116 (34%), Positives = 56/116 (48%), Gaps = 16/116 (13%)

Query: 244 PHLLERNGEGLSASRHSLRTG-LSASNLSLRGESPLSLLLGHLLPS-------SRAGTPA 295
           PH+    G   SA+  S+ +G  SA  + L+   PL    G  LP+       + A  PA
Sbjct: 216 PHVYGSAGMIDSATPISMASGDYSAYGVPLK---PLCHAAGQTLPAIPVPIKPTPAAVPA 272

Query: 296 GSRCTTPVPTP-QNSPPS-SPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIH 349
                 P+PT   NSPPS SP+ S+  + +SQ S     E L SPAS  + +V +H
Sbjct: 273 LPALPAPIPTLLSNSPPSLSPTSSQ--TATSQSSPATPSETLTSPAS-ALHSVAVH 325


>gi|222352122 hypothetical protein LOC284297 [Homo sapiens]
          Length = 1573

 Score = 35.0 bits (79), Expect = 0.43
 Identities = 34/104 (32%), Positives = 41/104 (39%), Gaps = 16/104 (15%)

Query: 287  PSSRAGTPAGSRCTTPVPTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDIPTV 346
            P  R   PA +R   P P+P  S    P    LTS SS+E    +   L S A+ D P  
Sbjct: 990  PERRPPRPAATRTAPPTPSPGPSASPGPPGPALTSDSSRELTPHS--ALTSEATSDAPDT 1047

Query: 347  VIHPPEEDLEAALKGEEQKNEENVDLTPGILASPQSAPGNLDNS 390
               PP  D           +  N DL   IL SP  A    D+S
Sbjct: 1048 --SPPTPD---------PASRTNPDL---ILTSPDFALSTPDSS 1077


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,733,408
Number of Sequences: 37866
Number of extensions: 2488718
Number of successful extensions: 15676
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 115
Number of HSP's that attempted gapping in prelim test: 14622
Number of HSP's gapped (non-prelim): 985
length of query: 1214
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1100
effective length of database: 13,930,794
effective search space: 15323873400
effective search space used: 15323873400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.