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Search of human proteins with 134254466
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|134254466 patched isoform M [Homo sapiens]
(1381 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|134254466 patched isoform M [Homo sapiens] 2813 0.0
gi|134254432 patched isoform L' [Homo sapiens] 2811 0.0
gi|134254446 patched isoform L [Homo sapiens] 2811 0.0
gi|134254450 patched isoform S [Homo sapiens] 2643 0.0
gi|134254435 patched isoform S [Homo sapiens] 2643 0.0
gi|134254468 patched isoform S [Homo sapiens] 2643 0.0
gi|134254452 patched isoform S [Homo sapiens] 2643 0.0
gi|52145305 patched 2 [Homo sapiens] 1278 0.0
gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens] 130 7e-30
gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapi... 126 1e-28
gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapi... 110 1e-23
gi|239754873 PREDICTED: similar to hCG2040393 [Homo sapiens] 92 3e-18
gi|239749412 PREDICTED: hypothetical protein XP_002347031 [Homo ... 92 3e-18
gi|239743547 PREDICTED: hypothetical protein XP_002342883 [Homo ... 92 3e-18
gi|194018513 patched domain containing 3 [Homo sapiens] 84 7e-16
gi|148271104 patched domain containing 1 [Homo sapiens] 82 3e-15
gi|148277106 hypothetical protein LOC442213 [Homo sapiens] 79 2e-14
gi|66932902 SREBF chaperone protein [Homo sapiens] 70 1e-11
gi|149274653 patched domain containing 2 [Homo sapiens] 53 2e-06
gi|25952134 dispatched A [Homo sapiens] 50 1e-05
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 48 7e-05
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 48 7e-05
gi|150417989 cyclin K isoform 1 [Homo sapiens] 45 5e-04
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre... 44 8e-04
gi|112734870 hypothetical protein LOC57648 [Homo sapiens] 44 0.001
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 43 0.002
gi|224451135 splicing factor, arginine/serine-rich 15 isoform 3 ... 42 0.003
gi|224451133 splicing factor, arginine/serine-rich 15 isoform 2 ... 42 0.003
gi|40789229 splicing factor, arginine/serine-rich 15 isoform 1 [... 42 0.003
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin... 42 0.003
>gi|134254466 patched isoform M [Homo sapiens]
Length = 1381
Score = 2813 bits (7291), Expect = 0.0
Identities = 1381/1381 (100%), Positives = 1381/1381 (100%)
Query: 1 MGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVE 60
MGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVE
Sbjct: 1 MGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVE 60
Query: 61 ELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQAS 120
ELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQAS
Sbjct: 61 ELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQAS 120
Query: 121 RVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTA 180
RVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTA
Sbjct: 121 RVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTA 180
Query: 181 YLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPA 240
YLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPA
Sbjct: 181 YLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPA 240
Query: 241 TAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQL 300
TAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQL
Sbjct: 241 TAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQL 300
Query: 301 MTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTT 360
MTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTT
Sbjct: 301 MTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTT 360
Query: 361 LDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLG 420
LDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLG
Sbjct: 361 LDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLG 420
Query: 421 LCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGA 480
LCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGA
Sbjct: 421 LCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGA 480
Query: 481 SVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDR 540
SVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDR
Sbjct: 481 SVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDR 540
Query: 541 RLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRT 600
RLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRT
Sbjct: 541 RLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRT 600
Query: 601 EYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPP 660
EYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPP
Sbjct: 601 EYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPP 660
Query: 661 CTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETR 720
CTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETR
Sbjct: 661 CTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETR 720
Query: 721 EYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH 780
EYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH
Sbjct: 721 EYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH 780
Query: 781 YFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQR 840
YFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQR
Sbjct: 781 YFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQR 840
Query: 841 LVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAA 900
LVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAA
Sbjct: 841 LVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAA 900
Query: 901 EPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRH 960
EPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRH
Sbjct: 901 EPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRH 960
Query: 961 WLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVIL 1020
WLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVIL
Sbjct: 961 WLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVIL 1020
Query: 1021 IASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFD 1080
IASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFD
Sbjct: 1021 IASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFD 1080
Query: 1081 FIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVR 1140
FIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVR
Sbjct: 1081 FIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVR 1140
Query: 1141 FAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAH 1200
FAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAH
Sbjct: 1141 FAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAH 1200
Query: 1201 STVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEIS 1260
STVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEIS
Sbjct: 1201 STVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEIS 1260
Query: 1261 TEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPV 1320
TEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPV
Sbjct: 1261 TEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPV 1320
Query: 1321 PGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSS 1380
PGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSS
Sbjct: 1321 PGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSS 1380
Query: 1381 N 1381
N
Sbjct: 1381 N 1381
>gi|134254432 patched isoform L' [Homo sapiens]
Length = 1446
Score = 2811 bits (7286), Expect = 0.0
Identities = 1380/1380 (100%), Positives = 1380/1380 (100%)
Query: 2 GKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEE 61
GKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEE
Sbjct: 67 GKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEE 126
Query: 62 LWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASR 121
LWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASR
Sbjct: 127 LWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASR 186
Query: 122 VHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAY 181
VHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAY
Sbjct: 187 VHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAY 246
Query: 182 LLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPAT 241
LLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPAT
Sbjct: 247 LLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPAT 306
Query: 242 APNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLM 301
APNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLM
Sbjct: 307 APNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLM 366
Query: 302 TPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTL 361
TPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTL
Sbjct: 367 TPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTL 426
Query: 362 DDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGL 421
DDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGL
Sbjct: 427 DDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGL 486
Query: 422 CSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGAS 481
CSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGAS
Sbjct: 487 CSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGAS 546
Query: 482 VALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRR 541
VALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRR
Sbjct: 547 VALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRR 606
Query: 542 LDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTE 601
LDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTE
Sbjct: 607 LDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTE 666
Query: 602 YDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPC 661
YDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPC
Sbjct: 667 YDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPC 726
Query: 662 TKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETRE 721
TKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETRE
Sbjct: 727 TKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETRE 786
Query: 722 YDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHY 781
YDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHY
Sbjct: 787 YDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHY 846
Query: 782 FRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRL 841
FRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRL
Sbjct: 847 FRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRL 906
Query: 842 VDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAE 901
VDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAE
Sbjct: 907 VDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAE 966
Query: 902 PIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHW 961
PIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHW
Sbjct: 967 PIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHW 1026
Query: 962 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 1021
LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI
Sbjct: 1027 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 1086
Query: 1022 ASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDF 1081
ASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDF
Sbjct: 1087 ASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDF 1146
Query: 1082 IVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRF 1141
IVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRF
Sbjct: 1147 IVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRF 1206
Query: 1142 AMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHS 1201
AMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHS
Sbjct: 1207 AMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHS 1266
Query: 1202 TVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEIST 1261
TVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEIST
Sbjct: 1267 TVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEIST 1326
Query: 1262 EGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVP 1321
EGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVP
Sbjct: 1327 EGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVP 1386
Query: 1322 GPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1381
GPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN
Sbjct: 1387 GPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1446
>gi|134254446 patched isoform L [Homo sapiens]
Length = 1447
Score = 2811 bits (7286), Expect = 0.0
Identities = 1380/1380 (100%), Positives = 1380/1380 (100%)
Query: 2 GKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEE 61
GKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEE
Sbjct: 68 GKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEE 127
Query: 62 LWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASR 121
LWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASR
Sbjct: 128 LWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASR 187
Query: 122 VHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAY 181
VHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAY
Sbjct: 188 VHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAY 247
Query: 182 LLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPAT 241
LLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPAT
Sbjct: 248 LLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPAT 307
Query: 242 APNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLM 301
APNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLM
Sbjct: 308 APNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLM 367
Query: 302 TPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTL 361
TPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTL
Sbjct: 368 TPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTL 427
Query: 362 DDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGL 421
DDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGL
Sbjct: 428 DDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGL 487
Query: 422 CSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGAS 481
CSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGAS
Sbjct: 488 CSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGAS 547
Query: 482 VALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRR 541
VALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRR
Sbjct: 548 VALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRR 607
Query: 542 LDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTE 601
LDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTE
Sbjct: 608 LDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTE 667
Query: 602 YDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPC 661
YDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPC
Sbjct: 668 YDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPC 727
Query: 662 TKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETRE 721
TKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETRE
Sbjct: 728 TKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETRE 787
Query: 722 YDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHY 781
YDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHY
Sbjct: 788 YDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHY 847
Query: 782 FRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRL 841
FRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRL
Sbjct: 848 FRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRL 907
Query: 842 VDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAE 901
VDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAE
Sbjct: 908 VDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAE 967
Query: 902 PIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHW 961
PIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHW
Sbjct: 968 PIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHW 1027
Query: 962 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 1021
LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI
Sbjct: 1028 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 1087
Query: 1022 ASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDF 1081
ASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDF
Sbjct: 1088 ASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDF 1147
Query: 1082 IVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRF 1141
IVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRF
Sbjct: 1148 IVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRF 1207
Query: 1142 AMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHS 1201
AMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHS
Sbjct: 1208 AMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHS 1267
Query: 1202 TVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEIST 1261
TVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEIST
Sbjct: 1268 TVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEIST 1327
Query: 1262 EGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVP 1321
EGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVP
Sbjct: 1328 EGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVP 1387
Query: 1322 GPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1381
GPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN
Sbjct: 1388 GPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1447
>gi|134254450 patched isoform S [Homo sapiens]
Length = 1296
Score = 2644 bits (6852), Expect = 0.0
Identities = 1296/1296 (100%), Positives = 1296/1296 (100%)
Query: 86 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 145
MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT
Sbjct: 1 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60
Query: 146 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 205
ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI
Sbjct: 61 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120
Query: 206 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 265
NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS
Sbjct: 121 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180
Query: 266 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 325
RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK
Sbjct: 181 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240
Query: 326 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 385
AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA
Sbjct: 241 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300
Query: 386 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 445
YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG
Sbjct: 301 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360
Query: 446 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 505
VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR
Sbjct: 361 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420
Query: 506 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 565
AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT
Sbjct: 421 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480
Query: 566 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 625
DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT
Sbjct: 481 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540
Query: 626 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 685
VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV
Sbjct: 541 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600
Query: 686 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 745
VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD
Sbjct: 601 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660
Query: 746 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 805
YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN
Sbjct: 661 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720
Query: 806 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 865
NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP
Sbjct: 721 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780
Query: 866 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 925
VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI
Sbjct: 781 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840
Query: 926 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 985
EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW
Sbjct: 841 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900
Query: 986 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 1045
TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK
Sbjct: 901 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960
Query: 1046 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1105
NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL
Sbjct: 961 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
Query: 1106 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1165
PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV
Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080
Query: 1166 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1225
SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG
Sbjct: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140
Query: 1226 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1285
SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN
Sbjct: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200
Query: 1286 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1345
PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED
Sbjct: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260
Query: 1346 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1381
PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN
Sbjct: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296
>gi|134254435 patched isoform S [Homo sapiens]
Length = 1296
Score = 2644 bits (6852), Expect = 0.0
Identities = 1296/1296 (100%), Positives = 1296/1296 (100%)
Query: 86 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 145
MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT
Sbjct: 1 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60
Query: 146 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 205
ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI
Sbjct: 61 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120
Query: 206 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 265
NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS
Sbjct: 121 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180
Query: 266 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 325
RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK
Sbjct: 181 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240
Query: 326 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 385
AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA
Sbjct: 241 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300
Query: 386 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 445
YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG
Sbjct: 301 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360
Query: 446 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 505
VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR
Sbjct: 361 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420
Query: 506 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 565
AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT
Sbjct: 421 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480
Query: 566 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 625
DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT
Sbjct: 481 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540
Query: 626 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 685
VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV
Sbjct: 541 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600
Query: 686 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 745
VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD
Sbjct: 601 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660
Query: 746 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 805
YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN
Sbjct: 661 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720
Query: 806 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 865
NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP
Sbjct: 721 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780
Query: 866 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 925
VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI
Sbjct: 781 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840
Query: 926 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 985
EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW
Sbjct: 841 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900
Query: 986 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 1045
TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK
Sbjct: 901 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960
Query: 1046 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1105
NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL
Sbjct: 961 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
Query: 1106 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1165
PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV
Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080
Query: 1166 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1225
SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG
Sbjct: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140
Query: 1226 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1285
SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN
Sbjct: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200
Query: 1286 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1345
PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED
Sbjct: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260
Query: 1346 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1381
PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN
Sbjct: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296
>gi|134254468 patched isoform S [Homo sapiens]
Length = 1296
Score = 2644 bits (6852), Expect = 0.0
Identities = 1296/1296 (100%), Positives = 1296/1296 (100%)
Query: 86 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 145
MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT
Sbjct: 1 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60
Query: 146 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 205
ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI
Sbjct: 61 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120
Query: 206 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 265
NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS
Sbjct: 121 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180
Query: 266 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 325
RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK
Sbjct: 181 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240
Query: 326 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 385
AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA
Sbjct: 241 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300
Query: 386 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 445
YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG
Sbjct: 301 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360
Query: 446 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 505
VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR
Sbjct: 361 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420
Query: 506 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 565
AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT
Sbjct: 421 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480
Query: 566 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 625
DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT
Sbjct: 481 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540
Query: 626 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 685
VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV
Sbjct: 541 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600
Query: 686 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 745
VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD
Sbjct: 601 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660
Query: 746 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 805
YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN
Sbjct: 661 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720
Query: 806 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 865
NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP
Sbjct: 721 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780
Query: 866 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 925
VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI
Sbjct: 781 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840
Query: 926 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 985
EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW
Sbjct: 841 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900
Query: 986 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 1045
TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK
Sbjct: 901 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960
Query: 1046 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1105
NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL
Sbjct: 961 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
Query: 1106 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1165
PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV
Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080
Query: 1166 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1225
SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG
Sbjct: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140
Query: 1226 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1285
SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN
Sbjct: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200
Query: 1286 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1345
PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED
Sbjct: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260
Query: 1346 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1381
PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN
Sbjct: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296
>gi|134254452 patched isoform S [Homo sapiens]
Length = 1296
Score = 2644 bits (6852), Expect = 0.0
Identities = 1296/1296 (100%), Positives = 1296/1296 (100%)
Query: 86 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 145
MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT
Sbjct: 1 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60
Query: 146 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 205
ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI
Sbjct: 61 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120
Query: 206 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 265
NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS
Sbjct: 121 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180
Query: 266 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 325
RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK
Sbjct: 181 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240
Query: 326 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 385
AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA
Sbjct: 241 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300
Query: 386 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 445
YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG
Sbjct: 301 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360
Query: 446 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 505
VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR
Sbjct: 361 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420
Query: 506 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 565
AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT
Sbjct: 421 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480
Query: 566 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 625
DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT
Sbjct: 481 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540
Query: 626 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 685
VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV
Sbjct: 541 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600
Query: 686 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 745
VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD
Sbjct: 601 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660
Query: 746 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 805
YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN
Sbjct: 661 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720
Query: 806 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 865
NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP
Sbjct: 721 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780
Query: 866 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 925
VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI
Sbjct: 781 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840
Query: 926 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 985
EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW
Sbjct: 841 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900
Query: 986 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 1045
TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK
Sbjct: 901 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960
Query: 1046 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1105
NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL
Sbjct: 961 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
Query: 1106 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1165
PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV
Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080
Query: 1166 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1225
SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG
Sbjct: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140
Query: 1226 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1285
SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN
Sbjct: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200
Query: 1286 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1345
PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED
Sbjct: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260
Query: 1346 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1381
PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN
Sbjct: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296
>gi|52145305 patched 2 [Homo sapiens]
Length = 1203
Score = 1278 bits (3306), Expect = 0.0
Identities = 634/1114 (56%), Positives = 828/1114 (74%), Gaps = 27/1114 (2%)
Query: 8 KAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVG 67
KAPLWLRA FQ LLF LGC IQ++CGK L +GLL FGA A+GL+ A +ETN+E+LWVEVG
Sbjct: 31 KAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVG 90
Query: 68 GRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMY 127
RVS+EL+YT++K+GEEA + Q++IQT ++EG N+LT EAL HL +AL AS+V V +Y
Sbjct: 91 SRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLY 150
Query: 128 NRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPP 187
+ W L +CYKSG + E G ++++IE L+PC+I+TPLDCFWEGAKLQ G+AYL G+P
Sbjct: 151 GKSWDLNKICYKSGVPLIENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPD 210
Query: 188 LRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNS 247
++WTN DP + LEEL ++ + E+L+KA+VG Y+ RPCL+P D CP +APN +S
Sbjct: 211 IQWTNLDPEQLLEELGPFA-SLEGFRELLDKAQVGQAYVGRPCLHPDDLHCPPSAPNHHS 269
Query: 248 TKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMY 307
+ ++A L+GGCHG S K+MHWQEEL++GG ++ G+L+ A ALQ+ F LM+P+Q+Y
Sbjct: 270 RQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQLY 329
Query: 308 EHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKS 367
EHF+G I W+E++A+ +L+AWQR +V++ +++ +N++Q++ +F++TTLDDIL +
Sbjct: 330 EHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHA 389
Query: 368 FSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGI 427
FS+VS RV GYLLMLAYAC+TMLRWDC++SQG+VGLAGVLLVAL+VA+GLGLC+L+GI
Sbjct: 390 FSEVSAARVVGGYLLMLAYACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGI 449
Query: 428 SFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSI 487
+FNAATTQVLPFLALG+GVDDVFLLAHAF+E P ++R GECL+RTG SV LTSI
Sbjct: 450 TFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPG--TPLQERMGECLQRTGTSVVLTSI 507
Query: 488 SNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 547
+N+ AF MAAL+PIPALRAFSLQAA+VV F V+L+FPAILS+DL RR +RLD+ CC
Sbjct: 508 NNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCC 567
Query: 548 FTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTH 607
F+SPC ++VIQ+ PQ D P +H + +TVQ T + +
Sbjct: 568 FSSPCSAQVIQILPQELGD-------GTVPVGIAH---------LTATVQAFTHCEASSQ 611
Query: 608 VYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDS--SLHCLEPPCTKWT 665
T P++ + P D L + STRDLL Q ++ C PC +W
Sbjct: 612 HVVTILPPQAHLVPPP----SDPLGSELFSPGGSTRDLLGQEEETRQKAACKSLPCARWN 667
Query: 666 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 725
L+ FA +AP LL+ AK +V+ LF LLG+SLYG T V+DGL LTD+VPR T+E+ F+
Sbjct: 668 LAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFL 727
Query: 726 AAQFKYFSFYNMYIVTQKA-DYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRD 784
+AQ +YFS Y + +VTQ DY + Q L+DLH+ FS++K V+ Q P+ WLHY+R+
Sbjct: 728 SAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRN 787
Query: 785 WLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDA 844
WLQG+Q AFD DW +G+I ++Y+NGS+DG LAYKLL+QTG +P+D SQLT ++LVD
Sbjct: 788 WLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDR 847
Query: 845 DGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIE 904
+G+I P FY+ LT WVS+DP+ AASQAN P PEW+HDK D E LRIP A+P+E
Sbjct: 848 EGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGE-NLRIPPAQPLE 906
Query: 905 YAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLL 964
+AQFPF L GL+ T+DFVEAIE R C+ G+ +YP+G PFLFWEQY+GLR LL
Sbjct: 907 FAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLL 966
Query: 965 FISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASV 1024
+ ++L CTFLVCA+ LLNPWTAG+IV+VLA+MTVELFG+MG +GIKLSA+PVVIL+ASV
Sbjct: 967 AVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASV 1026
Query: 1025 GIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVR 1084
GIGVEFTVHVAL FLT G +N RA ALEH FAPV DGA+STLLG+LMLAGS FDFIVR
Sbjct: 1027 GIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVR 1086
Query: 1085 YFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEV 1118
YFFA L +LT+LG+L+GLVLLPVLLS GP PEV
Sbjct: 1087 YFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEV 1120
Score = 31.2 bits (69), Expect = 7.2
Identities = 16/35 (45%), Positives = 22/35 (62%), Gaps = 5/35 (14%)
Query: 1293 SSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1327
SS+P +TT S+TVA+HPPP+PG +P
Sbjct: 1147 SSLPQSFARVTT-----SMTVAIHPPPLPGAYIHP 1176
>gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens]
Length = 1278
Score = 130 bits (328), Expect = 7e-30
Identities = 126/476 (26%), Positives = 214/476 (44%), Gaps = 66/476 (13%)
Query: 666 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 725
L F + Y+P LLK + +VI +F+G+L S+ +V GLD + +P ++ D+
Sbjct: 817 LFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYF 876
Query: 726 AAQFKYF-SFYNMYIVTQKA-DYP--------------NIQHLLYDLHRSFSNVKYVMLE 769
+ +Y + +Y V ++ DY N L+ + + Y +
Sbjct: 877 KSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIG 936
Query: 770 ENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGS--DDGVLAYKLLVQTGSR 827
P W+ + DW++ D T + + N S D + + L G
Sbjct: 937 F---APSSWIDDYFDWVKPQSSCCRVDNIT-----DQFCNASVVDPACVRCRPLTPEG-- 986
Query: 828 DKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKA 887
KQR D F +L ++S++P P + H A
Sbjct: 987 ----------KQRPQGGD-------FMRFLPMFLSDNP----------NPKCGKGGH--A 1017
Query: 888 DYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSS---- 942
Y + + + F Y L+ ++DF++A++K R I SN T ++G++
Sbjct: 1018 AYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYR 1077
Query: 943 -YPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFL-LNPWTAGIIVMVLALMTVE 1000
+P ++F+EQY+ + + + V L FLV V L W+A I+ +A++ V
Sbjct: 1078 VFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVN 1137
Query: 1001 LFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAI-GDKNRRAVLALEHMFAP 1059
+FG+M L GI L+AV +V L+ S GI VEF H+ AF ++ G + RA AL HM +
Sbjct: 1138 MFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSS 1197
Query: 1060 VLDGAVSTLL-GVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1114
V G T G+++LA ++ ++F + + +LG +GL+ LPVLLS+ GP
Sbjct: 1198 VFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGP 1253
Score = 130 bits (326), Expect = 1e-29
Identities = 77/233 (33%), Positives = 123/233 (52%), Gaps = 9/233 (3%)
Query: 321 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASG 379
+N+ + +AW++ ++ V N T +SFT +++D L SD V V
Sbjct: 571 YNDTEKLQRAQAWEKEFINFVKNYKNPNLT---ISFTAERSIEDELNRESDSDVFTVVIS 627
Query: 380 YLLMLAYACLTM-----LRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATT 434
Y +M Y L + R S+ ++G+AG+L+V SVA LG+ S IG+
Sbjct: 628 YAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVI 687
Query: 435 QVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFF 494
+V+PFL L VGVD++F+L A+ + + + + G L S+ L+S S AFF
Sbjct: 688 EVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFF 747
Query: 495 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 547
+ AL +PA+ FSL A + V +F + + F ++L +D+ R+E RLDIFCC
Sbjct: 748 LGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC 800
>gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapiens]
Length = 1332
Score = 126 bits (317), Expect = 1e-28
Identities = 140/544 (25%), Positives = 236/544 (43%), Gaps = 96/544 (17%)
Query: 666 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 725
L F +K YAPFLL + VV+ LFL L GVSLY + GLD +P+++ D+
Sbjct: 828 LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYF 887
Query: 726 AAQFKYFSF-----------YN------MYIVTQKADYPNI---QHLLYDLHRSFSNVKY 765
+YF YN M + A N Q + Y F Y
Sbjct: 888 LFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATE--FPEQSY 945
Query: 766 VMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTG 825
+ + + W+ F DWL P++ +L +
Sbjct: 946 LAIPASS-----WVDDFIDWLT----------------PSS----------CCRLYISGP 974
Query: 826 SRDK--PIDISQLT--KQRLVDADGIINPSA--FYIYLTAWVSNDPVAYAASQANIRPHR 879
++DK P ++ L K + G + PS F+ YL W ND + + +
Sbjct: 975 NKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLP-WFLNDRPNIKCPKGGLAAY- 1032
Query: 880 PEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTS-- 937
T + + + + ++F Y L+++ D+ EA+ R + +N T+
Sbjct: 1033 ------------STSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL 1080
Query: 938 -------LGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGII 990
+P +F+EQY+ + L +S+ L TF V + L +G++
Sbjct: 1081 RKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLL 1140
Query: 991 -VMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKN--- 1046
++ + ++ V+ G M L GI +AV ++ L+++VG+ VEF H+ +F AI K
Sbjct: 1141 NLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSF--AISTKPTWL 1198
Query: 1047 RRAVLALEHMFAPVLDG-AVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1105
RA A M + V G A++ L G+L+L ++ I +FF + ++T+LG+L+GLV L
Sbjct: 1199 ERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFL 1258
Query: 1106 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTH--SGSDSSDSEYSSQT 1163
PV+LS+ G P+V+PA L + E + V A P H S +D+ +S +
Sbjct: 1259 PVILSYVG--PDVNPALALEQ---KRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEG 1313
Query: 1164 TVSG 1167
++ G
Sbjct: 1314 SIKG 1317
Score = 110 bits (274), Expect = 1e-23
Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 6/230 (2%)
Query: 324 DKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASGYLL 382
D A + W+ ++E + + + ++F +L+D + + + A+ Y++
Sbjct: 583 DPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIV 642
Query: 383 MLAYACLTMLRWDCSK-----SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVL 437
+ Y L + + S+ +GL GV +V +V A +G S +GI + QV+
Sbjct: 643 IFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVV 702
Query: 438 PFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA 497
PFL L VG D++F+ + + P E G L R S+ L S+S FF+ A
Sbjct: 703 PFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGA 762
Query: 498 LIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 547
L P+PA+R F+L + + V+ +F + + F A+LS+D R+E RLD+ CC
Sbjct: 763 LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812
>gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo
sapiens]
Length = 1359
Score = 110 bits (274), Expect = 1e-23
Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 6/230 (2%)
Query: 324 DKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASGYLL 382
D A + W+ ++E + + + ++F +L+D + + + A+ Y++
Sbjct: 583 DPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIV 642
Query: 383 MLAYACLTMLRWDCSK-----SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVL 437
+ Y L + + S+ +GL GV +V +V A +G S +GI + QV+
Sbjct: 643 IFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVV 702
Query: 438 PFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA 497
PFL L VG D++F+ + + P E G L R S+ L S+S FF+ A
Sbjct: 703 PFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGA 762
Query: 498 LIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 547
L P+PA+R F+L + + V+ +F + + F A+LS+D R+E RLD+ CC
Sbjct: 763 LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812
Score = 103 bits (256), Expect = 1e-21
Identities = 82/278 (29%), Positives = 144/278 (51%), Gaps = 23/278 (8%)
Query: 906 AQFPFYLNGLRDTSDFVEAIEKVRTICSNYTS---------LGLSSYPNGYPFLFWEQYI 956
++F Y L+++ D+ EA+ R + +N T+ +P +F+EQY+
Sbjct: 1074 SRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYL 1133
Query: 957 GLRHWLLLFISVVLACTFLVCAVFLLNPWTAGII-VMVLALMTVELFGMMGLIGIKLSAV 1015
+ L +S+ L TF V + L +G++ ++ + ++ V+ G M L GI +AV
Sbjct: 1134 TILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAV 1193
Query: 1016 PVVILIASVGIGVEFTVHVALAFLTAIGDKN---RRAVLALEHMFAPVLDG-AVSTLLGV 1071
++ L+++VG+ VEF H+ +F AI K RA A M + V G A++ L G+
Sbjct: 1194 SLINLVSAVGMSVEFVSHITRSF--AISTKPTWLERAKEATISMGSAVFAGVAMTNLPGI 1251
Query: 1072 LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPS 1131
L+L ++ I +FF + ++T+LG+L+GLV LPV+LS+ G P+V+PA L +
Sbjct: 1252 LVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVG--PDVNPALALEQ---KR 1306
Query: 1132 PEPPPSVVRFAMPPGHTH--SGSDSSDSEYSSQTTVSG 1167
E + V A P H S +D+ +S + ++ G
Sbjct: 1307 AEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEGSIKG 1344
Score = 48.9 bits (115), Expect = 3e-05
Identities = 27/67 (40%), Positives = 37/67 (55%)
Query: 666 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 725
L F +K YAPFLL + VV+ LFL L GVSLY + GLD +P+++ D+
Sbjct: 828 LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYF 887
Query: 726 AAQFKYF 732
+YF
Sbjct: 888 LFLNRYF 894
>gi|239754873 PREDICTED: similar to hCG2040393 [Homo sapiens]
Length = 333
Score = 92.0 bits (227), Expect = 3e-18
Identities = 93/295 (31%), Positives = 113/295 (38%), Gaps = 52/295 (17%)
Query: 1120 PANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQ 1179
P + R P P P S R PG GS + + + RH +
Sbjct: 58 PGHTAPRTQQPKPSGPSSHPREPPLPGAVTGGS----LHFQEPPPLGAATAGSRHRQKPP 113
Query: 1180 GAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPS---NPRQQPHL-DSGSLPPGRQGQQ 1235
G E P +T R PPS HL SGS R
Sbjct: 114 SPGSR------HRWEPPPPGAATATGSRHRREPPSPGATTAGSCHLRSSGSTGTRRAPSH 167
Query: 1236 PR-------RDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWG---PRGARSHNP-- 1283
P R+ PRE PP P+ A EG S WG P+G R
Sbjct: 168 PAALQVPYTREGPREPT--PPAGPQGFAGSFCAEG-SRRGAEVGWGKLEPQGTRRTGSLG 224
Query: 1284 --RNPASTAMGSSVPG------------YCQPITTVTASASVTVAVHPPPVPGPGRNPRG 1329
+P S +G + G +C I + P PGP ++P+
Sbjct: 225 VDSSPLSETLGPAQCGSGRRRACSVLHHHCDGIRFRDCHCA------PSACPGPTQDPQA 278
Query: 1330 GLCPG---YPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1381
GLC G YP TDHGLF PH+ F V+ ER + KVEV ELQDVECEE PRGSSSN
Sbjct: 279 GLCTGQEGYPGTDHGLFMGPHLLFQVQGERTNLKVEVTELQDVECEEWPRGSSSN 333
>gi|239749412 PREDICTED: hypothetical protein XP_002347031 [Homo
sapiens]
Length = 333
Score = 92.0 bits (227), Expect = 3e-18
Identities = 93/295 (31%), Positives = 113/295 (38%), Gaps = 52/295 (17%)
Query: 1120 PANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQ 1179
P + R P P P S R PG GS + + + RH +
Sbjct: 58 PGHTAPRTQQPKPSGPSSHPREPPLPGAVTGGS----LHFQEPPPLGAATAGSRHRQKPP 113
Query: 1180 GAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPS---NPRQQPHL-DSGSLPPGRQGQQ 1235
G E P +T R PPS HL SGS R
Sbjct: 114 SPGSR------HRWEPPPPGAATATGSRHRREPPSPGATTAGSCHLRSSGSTGTRRAPSH 167
Query: 1236 PR-------RDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWG---PRGARSHNP-- 1283
P R+ PRE PP P+ A EG S WG P+G R
Sbjct: 168 PAALQVPYTREGPREPT--PPAGPQGFAGSFCAEG-SRRGAEVGWGKLEPQGTRRTGSLG 224
Query: 1284 --RNPASTAMGSSVPG------------YCQPITTVTASASVTVAVHPPPVPGPGRNPRG 1329
+P S +G + G +C I + P PGP ++P+
Sbjct: 225 VDSSPLSETLGPAQCGSGRRRACSVLHHHCDGIRFRDCHCA------PSACPGPTQDPQA 278
Query: 1330 GLCPG---YPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1381
GLC G YP TDHGLF PH+ F V+ ER + KVEV ELQDVECEE PRGSSSN
Sbjct: 279 GLCTGQEGYPGTDHGLFMGPHLLFQVQGERTNLKVEVTELQDVECEEWPRGSSSN 333
>gi|239743547 PREDICTED: hypothetical protein XP_002342883 [Homo
sapiens]
Length = 333
Score = 92.0 bits (227), Expect = 3e-18
Identities = 93/295 (31%), Positives = 113/295 (38%), Gaps = 52/295 (17%)
Query: 1120 PANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQ 1179
P + R P P P S R PG GS + + + RH +
Sbjct: 58 PGHTAPRTQQPKPSGPSSHPREPPLPGAVTGGS----LHFQEPPPLGAATAGSRHRQKPP 113
Query: 1180 GAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPS---NPRQQPHL-DSGSLPPGRQGQQ 1235
G E P +T R PPS HL SGS R
Sbjct: 114 SPGSR------HRWEPPPPGAATATGSRHRREPPSPGATTAGSCHLRSSGSTGTRRAPSH 167
Query: 1236 PR-------RDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWG---PRGARSHNP-- 1283
P R+ PRE PP P+ A EG S WG P+G R
Sbjct: 168 PAALQVPYTREGPREPT--PPAGPQGFAGSFCAEG-SRRGAEVGWGKLEPQGTRRTGSLG 224
Query: 1284 --RNPASTAMGSSVPG------------YCQPITTVTASASVTVAVHPPPVPGPGRNPRG 1329
+P S +G + G +C I + P PGP ++P+
Sbjct: 225 VDSSPLSETLGPAQCGSGRRRACSVLHHHCDGIRFRDCHCA------PSACPGPTQDPQA 278
Query: 1330 GLCPG---YPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1381
GLC G YP TDHGLF PH+ F V+ ER + KVEV ELQDVECEE PRGSSSN
Sbjct: 279 GLCTGQEGYPGTDHGLFMGPHLLFQVQGERTNLKVEVTELQDVECEEWPRGSSSN 333
>gi|194018513 patched domain containing 3 [Homo sapiens]
Length = 767
Score = 84.3 bits (207), Expect = 7e-16
Identities = 62/246 (25%), Positives = 120/246 (48%), Gaps = 20/246 (8%)
Query: 288 LVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQ 347
L+ A A++ ++ L T Y+ + ++++H+ D+ I +EVVH +
Sbjct: 316 LLRAKAMRLLYYLKTEDPEYD-VQSKQWLTHLL---DQFTNIKNILALKKIEVVHFT--- 368
Query: 348 NSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAG 407
S + L F T S + + V +A Y+L++ +A + R+DC +++ V G
Sbjct: 369 -SLSRQLEFEAT-------SVTVIPVFHLA--YILIILFAVTSCFRFDCIRNKMCVAAFG 418
Query: 408 VLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPF 467
V+ L+V +G GL IG+ F PFL LGVGVDD+F++ A+ +T N
Sbjct: 419 VISAFLAVVSGFGLLLHIGVPFVIIVAN-SPFLILGVGVDDMFIMISAWHKT--NLADDI 475
Query: 468 EDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFP 527
+R + S+ +T+I+N+ A + + +++ F + + ++F + + F
Sbjct: 476 RERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFG 535
Query: 528 AILSMD 533
A +++D
Sbjct: 536 AFMALD 541
Score = 60.5 bits (145), Expect = 1e-08
Identities = 37/128 (28%), Positives = 68/128 (53%), Gaps = 9/128 (7%)
Query: 666 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 725
+S F ++ PFL + ++K V+F+++ + S+YG V++GLDL ++ ++ +
Sbjct: 584 ISLFFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYF 643
Query: 726 AAQFKYFSFYN---MYIVTQKADY--PNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH 780
+ YFS Y M IVT+K DY +++ L + + F YV +K L + WL
Sbjct: 644 NVEENYFSDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYV----DKNLTEFWLD 699
Query: 781 YFRDWLQG 788
+ +L+G
Sbjct: 700 AYVQYLKG 707
>gi|148271104 patched domain containing 1 [Homo sapiens]
Length = 888
Score = 82.4 bits (202), Expect = 3e-15
Identities = 65/272 (23%), Positives = 126/272 (46%), Gaps = 24/272 (8%)
Query: 277 VGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRT 336
+GG +S ++ SA A+Q + Y+ IN D A E W+ +
Sbjct: 192 LGGVTVHSKDRVKSAEAIQLTY----------------YLQSINSLNDMVA---ERWESS 232
Query: 337 YVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDC 396
+ + V NS K+ +T+++L + + S VS + + +L++ A L DC
Sbjct: 233 FCDTVRLFQKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDC 292
Query: 397 SKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF 456
+S+ +GL G++ ++L+ G+ +L G +N +T +PF+ LG G+ F + ++
Sbjct: 293 VRSKPWLGLLGLVTISLATLTAAGIINLTGGKYN-STFLGVPFVMLGHGLYGTFEMLSSW 351
Query: 457 SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFSLQAAVV 514
+T +++ + ++RT + S +LT+ + F + A I A R F + +
Sbjct: 352 RKTREDQHV--KERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIA 409
Query: 515 VVFNFAMVLLIFPAILSMDLYRREDRRLDIFC 546
+ FN+ VL + + L Y + + IFC
Sbjct: 410 IFFNYLYVLSFYGSSLVFTGYIENNYQHSIFC 441
Score = 44.7 bits (104), Expect = 6e-04
Identities = 23/74 (31%), Positives = 40/74 (54%)
Query: 666 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 725
L F +++Y ++ K V+ +L + +L G +V +G DL++IV T+ ++
Sbjct: 483 LVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYT 542
Query: 726 AAQFKYFSFYNMYI 739
AQ KYFS Y+ I
Sbjct: 543 TAQQKYFSNYSPVI 556
Score = 31.6 bits (70), Expect = 5.5
Identities = 36/155 (23%), Positives = 66/155 (42%), Gaps = 16/155 (10%)
Query: 963 LLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVE--LFGMMGLIGIKLSAVPVVIL 1020
LLF S L A L+N W + L +++VE + G M L ++L + V+ L
Sbjct: 710 LLFFSAFLV------ADSLINVW------ITLTVVSVEFGVIGFMTLWKVELDCISVLCL 757
Query: 1021 IASVGIGVEFTVHVALAFLTAIGDKNRRAVL-ALEHMFAPVLDGAVSTLLGVLMLAGSEF 1079
I + ++ + F+ + V ALE +L + ++G++ LA
Sbjct: 758 IYGINYTIDNCAPMLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLIPLAAVPS 817
Query: 1080 DFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1114
+ F L ++ + + +LPV+L+F P
Sbjct: 818 NLTCT-LFRCLFLIAFVTFFHCFAILPVILTFLPP 851
>gi|148277106 hypothetical protein LOC442213 [Homo sapiens]
Length = 829
Score = 79.3 bits (194), Expect = 2e-14
Identities = 62/260 (23%), Positives = 112/260 (43%), Gaps = 7/260 (2%)
Query: 331 EAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLT 390
E W+ + +++ + ++ ++ S + +L S ++ +V +L+L A L+
Sbjct: 175 EKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLS 234
Query: 391 MLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVF 450
DC +S+ +GL GVL V +S+ G+ + +N +T +PF A+G G VF
Sbjct: 235 SSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYN-STLLGIPFFAMGHGTKGVF 293
Query: 451 LLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFS 508
L + T +N +PF+DR + + +TS F M A I A++ F
Sbjct: 294 ELLSGWRRTKEN--LPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFC 351
Query: 509 LQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF--TSPCVSRVIQVEPQAYTD 566
V ++ N+ + F + L ++R IFCC ++ + R +D
Sbjct: 352 QNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSD 411
Query: 567 THDNTRYSPPPPYSSHSFAH 586
H T + PY H H
Sbjct: 412 GHQQTSHHETNPYQHHFIQH 431
Score = 43.5 bits (101), Expect = 0.001
Identities = 43/183 (23%), Positives = 84/183 (45%), Gaps = 9/183 (4%)
Query: 666 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 725
+ F +HY ++ K V+ L+L S G ++ DG ++ +++ ++ +
Sbjct: 429 IQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYA 488
Query: 726 AAQFKYFSFYNMYI---VTQKADYPN--IQHLLYDLHRSFSNVKYV-MLEENKQLPKMWL 779
Q KYFS Y+ I V + +Y N +Q L L F+ V +V + ++ +
Sbjct: 489 MVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSA 548
Query: 780 HYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKL-LVQTGSRDKPIDISQL 836
+ D++ LQ +F E + K G + ++A +L LV SRDK +I+++
Sbjct: 549 NNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEV 608
Query: 837 TKQ 839
++
Sbjct: 609 LEK 611
Score = 41.6 bits (96), Expect = 0.005
Identities = 39/174 (22%), Positives = 78/174 (44%), Gaps = 12/174 (6%)
Query: 950 LFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTA----GIIVMVLALMTVEL--FG 1003
+F ++ + H+ L VL F V V +L + G ++L++ ++EL G
Sbjct: 625 VFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLG 684
Query: 1004 MMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLA-LEHMFAPVLD 1062
+M L + + + ++ LI ++ ++ + F+ A + + + L+ +L
Sbjct: 685 LMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQ 744
Query: 1063 GAVSTLLGV--LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1114
S L+G+ L+ S F + F L + +L+ V+LPV L+FF P
Sbjct: 745 NVTSFLIGLVPLLFVPSNLTFTL---FKCLLLTGGCTLLHCFVILPVFLTFFPP 795
>gi|66932902 SREBF chaperone protein [Homo sapiens]
Length = 1279
Score = 70.1 bits (170), Expect = 1e-11
Identities = 45/182 (24%), Positives = 90/182 (49%), Gaps = 6/182 (3%)
Query: 373 VIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAA 432
+I + + Y+++ AY + + D KS+ + LA V+ V S+ +GLC+L G++
Sbjct: 285 LIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLN 344
Query: 433 TTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTA 492
++ P+L + +G+++V +L + T + + R + L S+ + +
Sbjct: 345 GGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKL--RIAQGLSSESWSIMKNMATELGI 402
Query: 493 FFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRRE----DRRLDIFCCF 548
+ +PA++ F L A V +V +F + +L F +LS+D+ R E ++RL C
Sbjct: 403 ILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACL 462
Query: 549 TS 550
S
Sbjct: 463 PS 464
>gi|149274653 patched domain containing 2 [Homo sapiens]
Length = 1392
Score = 53.1 bits (126), Expect = 2e-06
Identities = 87/394 (22%), Positives = 152/394 (38%), Gaps = 65/394 (16%)
Query: 321 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGY 380
W E +A +++ TYV ++ A+ ST KV T D V R +
Sbjct: 415 WEEQRAK--FQSFVVTYVAML----AKQSTSKVQVLYGGT------DLFDYEVRRTFNND 462
Query: 381 LLM--LAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLI-GISFNAATTQVL 437
+L+ ++ +C+ L + + + G+ + LS L L ++ GI + V
Sbjct: 463 MLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVA 522
Query: 438 PFLALGVGVDDVFLLAHAFSETGQNKRIPFED---RTGECLKRTGASVALTSISNVTAFF 494
F+ +G+GVDDVF+ + + + ED R ++ G + TS++ A+
Sbjct: 523 AFVIVGIGVDDVFVFINTYRQATH-----LEDPQLRMIHTVQTAGKATFFTSLTTAAAYA 577
Query: 495 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVS 554
IPA+ F L +++V + VL+ PA L + + + +P
Sbjct: 578 ANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL------------WSLYLAP--- 622
Query: 555 RVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAE 614
+E T H N + FA Q+ D + E
Sbjct: 623 ----LESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEE 678
Query: 615 PRS-EIS-VQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEK 672
P S E+ V V+V+ + L Q +T S L+ Q + H W L S
Sbjct: 679 PVSLELGDVSLVSVSPEGL--QPASNTGSRGHLIVQLQELLHH--------WVLWSAV-- 726
Query: 673 HYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVR 706
K++ V++ LF+ +L +SL +R+R
Sbjct: 727 ---------KSRWVIVGLFVSILILSLVFASRLR 751
Score = 32.3 bits (72), Expect = 3.2
Identities = 35/167 (20%), Positives = 67/167 (40%), Gaps = 39/167 (23%)
Query: 962 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 1021
+LL + V+L+ +VC V + W+ G ++ AV + L
Sbjct: 1205 ILLLLPVLLSILGIVCLVVTIMYWS----------------------GWEMGAVEAISLS 1242
Query: 1022 ASVGIGVEFTVHVALAFL------------TAIGDKNRRAVLALEHMFAPVLDGAVSTLL 1069
VG V++ VH+ +L A + R + A+ H+ ++ A++T++
Sbjct: 1243 ILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVI 1302
Query: 1070 GVLMLAGSEFDFIVRY--FFAVLAILTILGVLNGLVLLPVLLSFFGP 1114
+ L F I + F ++A+ T + +L L + LL P
Sbjct: 1303 ATVPLF---FCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAP 1346
>gi|25952134 dispatched A [Homo sapiens]
Length = 1524
Score = 50.4 bits (119), Expect = 1e-05
Identities = 29/113 (25%), Positives = 55/113 (48%), Gaps = 5/113 (4%)
Query: 440 LALGVGVDDVFLLAHAFSETGQNK-RIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL 498
+ +G+G DD F+L ++ T +K + L+ S+ +TS + AF+ +
Sbjct: 565 ILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYV 624
Query: 499 IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSP 551
I A+R F + A ++ N+ +++ PA++ + E L+IF CF P
Sbjct: 625 SNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKP 673
Score = 41.2 bits (95), Expect = 0.007
Identities = 41/173 (23%), Positives = 79/173 (45%), Gaps = 21/173 (12%)
Query: 921 FVEAIEKVRTI---CSNYTSLGLSSYPNGYP-------FLFWEQYIGLRHWLLLFISVVL 970
F A EK+ ++ S LSS P G F++ L L+ + + +
Sbjct: 933 FTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSV 992
Query: 971 ACTFLVCAVFLLNPWTAGIIVMVLALMTVE-----LFGMMGLIGIKLSAVPVVILIASVG 1025
A F +V LL W II+ + A++++ G + L+G +L+ + V + +VG
Sbjct: 993 AVAF---SVMLLTTWN--IIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVG 1047
Query: 1026 IGVEFTVHVALAF-LTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGS 1077
+ V+F VH +A+ L D+ + + +L + + + A++T + M+ S
Sbjct: 1048 LSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 1100
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 855
Score = 47.8 bits (112), Expect = 7e-05
Identities = 67/245 (27%), Positives = 89/245 (36%), Gaps = 32/245 (13%)
Query: 1112 FGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEE 1171
F P P +SP L TP P+ PP++ A+PP S + S T S +
Sbjct: 380 FLPSPPLSP------LATPPPQAPPAL---ALPPLQA-PPSPPASPPLSPLATPSPQAPN 429
Query: 1172 LRHYEAQQGAGGPAHQVIVEATENPVFAH--STVVHPESR----------HHPPSNPRQQ 1219
Q P V+A +P + S P S+ PPS P
Sbjct: 430 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 489
Query: 1220 PHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGAR 1279
P S + PP Q P PP + PPP P A S P++ P
Sbjct: 490 PMSPSATPPP--QAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 547
Query: 1280 SHNPRNPASTAMGSSVPGYCQPITTVTAS--ASVTV-AVHPPPVPGPGRNPRG-----GL 1331
+ P +P +T + P P+ V S AS T+ A PP PGP + G L
Sbjct: 548 ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLAL 607
Query: 1332 CPGYP 1336
PG P
Sbjct: 608 APGPP 612
Score = 31.6 bits (70), Expect = 5.5
Identities = 41/164 (25%), Positives = 56/164 (34%), Gaps = 34/164 (20%)
Query: 1130 PSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVI 1189
P P PPPS P T SG D + S+ +T EELR Y++ G
Sbjct: 609 PGPPPPPS-----RSPSSTLSGPDLAGHSSSATST----PEELRGYDSGPEGGA------ 653
Query: 1190 VEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLP------PGR--------QGQQ 1235
A P A HP + P+ P LP PG + +
Sbjct: 654 --AASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEG 711
Query: 1236 PRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGAR 1279
P P G P P + + +G S+R+ P+ AR
Sbjct: 712 PESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRS---PKQAR 752
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
Length = 816
Score = 47.8 bits (112), Expect = 7e-05
Identities = 67/245 (27%), Positives = 89/245 (36%), Gaps = 32/245 (13%)
Query: 1112 FGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEE 1171
F P P +SP L TP P+ PP++ A+PP S + S T S +
Sbjct: 341 FLPSPPLSP------LATPPPQAPPAL---ALPPLQA-PPSPPASPPLSPLATPSPQAPN 390
Query: 1172 LRHYEAQQGAGGPAHQVIVEATENPVFAH--STVVHPESR----------HHPPSNPRQQ 1219
Q P V+A +P + S P S+ PPS P
Sbjct: 391 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 450
Query: 1220 PHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGAR 1279
P S + PP Q P PP + PPP P A S P++ P
Sbjct: 451 PMSPSATPPP--QAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 508
Query: 1280 SHNPRNPASTAMGSSVPGYCQPITTVTAS--ASVTV-AVHPPPVPGPGRNPRG-----GL 1331
+ P +P +T + P P+ V S AS T+ A PP PGP + G L
Sbjct: 509 ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLAL 568
Query: 1332 CPGYP 1336
PG P
Sbjct: 569 APGPP 573
Score = 35.8 bits (81), Expect = 0.29
Identities = 53/218 (24%), Positives = 72/218 (33%), Gaps = 36/218 (16%)
Query: 1114 PYPEVSPANG---LNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSE 1170
P + +PA G + L TPSP PPS + PP + S + SQ T S
Sbjct: 279 PRKDAAPALGPLSSSPLATPSPSAPPSP---SAPP--SLQTLPSPPATPPSQATTS---- 329
Query: 1171 ELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPG 1230
G P Q HS + P P+ P L +LPP
Sbjct: 330 ----------LGSPTLQA----------THSFLPSPPLSPLATPPPQAPPAL---ALPPL 366
Query: 1231 RQGQQPRRDPPREGL-WPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPAST 1289
+ P PP L P P P A + S P + P + P +P++T
Sbjct: 367 QAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT 426
Query: 1290 AMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1327
+ P P V S + + P P P P
Sbjct: 427 PPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 464
Score = 31.6 bits (70), Expect = 5.5
Identities = 41/164 (25%), Positives = 56/164 (34%), Gaps = 34/164 (20%)
Query: 1130 PSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVI 1189
P P PPPS P T SG D + S+ +T EELR Y++ G
Sbjct: 570 PGPPPPPS-----RSPSSTLSGPDLAGHSSSATST----PEELRGYDSGPEGGA------ 614
Query: 1190 VEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLP------PGR--------QGQQ 1235
A P A HP + P+ P LP PG + +
Sbjct: 615 --AASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEG 672
Query: 1236 PRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGAR 1279
P P G P P + + +G S+R+ P+ AR
Sbjct: 673 PESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRS---PKQAR 713
>gi|150417989 cyclin K isoform 1 [Homo sapiens]
Length = 580
Score = 45.1 bits (105), Expect = 5e-04
Identities = 55/204 (26%), Positives = 69/204 (33%), Gaps = 37/204 (18%)
Query: 1128 PTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQ 1187
P P +PPP R PP ++ S+ S Y S E + ++ GP++
Sbjct: 407 PAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMS-------GEGYQSLQSMMKTEGPSYG 459
Query: 1188 VIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWP 1247
+ A P AH P H P NP P PP P PP G P
Sbjct: 460 ALPPAYGPP--AHL----PYHPHVYPPNPPPPP-----VPPPPASFPPPAIPPPTPGYPP 508
Query: 1248 PPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTA 1307
PP T + P R P A +P G +P P V
Sbjct: 509 PP----------PTYNPNFPPPPPRLPPTHAVPPHP------PPGLGLPPASYPPPAVPP 552
Query: 1308 SASVTVAVHPPPVPGPGRNPRGGL 1331
V PPP+P PG P GGL
Sbjct: 553 GGQPPV---PPPIPPPGMPPVGGL 573
Score = 32.3 bits (72), Expect = 3.2
Identities = 43/168 (25%), Positives = 53/168 (31%), Gaps = 28/168 (16%)
Query: 1190 VEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGR---------QGQQP---- 1236
V+AT+ P HP H PP P + P S G +G Q
Sbjct: 391 VDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSM 450
Query: 1237 -RRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSV 1295
+ + P G PP Y P + H P N P P + A+
Sbjct: 451 MKTEGPSYGALPPAYGP---PAHLPYHPHVYPPN----PPPPPVPPPPASFPPPAIPPPT 503
Query: 1296 PGYCQPITTVTAS-------ASVTVAVHPPPVPGPGRNPRGGLCPGYP 1336
PGY P T + T AV P P PG G P P P
Sbjct: 504 PGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVP 551
>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
preproprotein [Homo sapiens]
Length = 331
Score = 44.3 bits (103), Expect = 8e-04
Identities = 39/133 (29%), Positives = 50/133 (37%), Gaps = 31/133 (23%)
Query: 1215 NPRQQPHLDSGSLPPGRQGQQPRRDPPREG--LWPPPYRPRRDAFEISTEGHSGPSNRAR 1272
+PR P G PP + G QP+ PP G PPP R +G P
Sbjct: 89 SPRSPPGKPQG--PPPQGGNQPQGPPPPPGKPQGPPPQGGNR------PQGPPPPGKPQG 140
Query: 1273 WGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGP--------G 1324
P+G +S +PR+P G G QP PPP PG G
Sbjct: 141 PPPQGDKSRSPRSPPGKPQGPPPQGGNQP-------------QGPPPPPGKPQGPPPQGG 187
Query: 1325 RNPRGGLCPGYPE 1337
+ P+G PG P+
Sbjct: 188 KKPQGPPPPGKPQ 200
Score = 36.6 bits (83), Expect = 0.17
Identities = 35/126 (27%), Positives = 48/126 (38%), Gaps = 24/126 (19%)
Query: 1223 DSGSLPPGR-QGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGP--RGAR 1279
+S SL G QG P+ +G PPP +P+ + + P GP +G +
Sbjct: 27 ESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDK 86
Query: 1280 SHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGP--------GRNPRGGL 1331
S +PR+P G G QP PPP PG G P+G
Sbjct: 87 SRSPRSPPGKPQGPPPQGGNQP-------------QGPPPPPGKPQGPPPQGGNRPQGPP 133
Query: 1332 CPGYPE 1337
PG P+
Sbjct: 134 PPGKPQ 139
>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
Length = 1094
Score = 43.5 bits (101), Expect = 0.001
Identities = 47/218 (21%), Positives = 81/218 (37%), Gaps = 44/218 (20%)
Query: 1114 PYPEV----SPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLS 1169
P+P+V SP R P P+ P++ A+ PG + S S + QTT++ L
Sbjct: 662 PHPKVPAPFSPPPSKPRSPNPAA---PALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQ 718
Query: 1170 EELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPP 1229
E ++ ++P + P +HPP P ++P + +
Sbjct: 719 ES----------------PVISKDQSPPPS------PPPSYHPPPPPTKKPEVVVEAPSA 756
Query: 1230 GRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPAST 1289
++P +DP WPPP P + ++S P S P P+ +
Sbjct: 757 SETAEEPLQDPN----WPPPPPPAPEEQDLSMADFPPPEEAF----FSVASPEPAGPSGS 808
Query: 1290 AMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1327
S P ++S++ + + PP P P P
Sbjct: 809 PELVSSP-------AASSSSATALQIQPPGSPDPPPAP 839
>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
Length = 416
Score = 42.7 bits (99), Expect = 0.002
Identities = 39/142 (27%), Positives = 50/142 (35%), Gaps = 31/142 (21%)
Query: 1206 PESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREG--LWPPPYRPRRDAFEISTEG 1263
P + P P P G PP + G QP+ PP G PPP + +G
Sbjct: 40 PPQGGNKPQGPPSPPGKPQG--PPPQGGNQPQGPPPPPGKPQGPPPQGGNK------PQG 91
Query: 1264 HSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGP 1323
P P+G +S +PR+P G G QP PPP PG
Sbjct: 92 PPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQP-------------QGPPPPPGK 138
Query: 1324 --------GRNPRGGLCPGYPE 1337
G P+G PG P+
Sbjct: 139 PQGPPPQGGNKPQGPPPPGKPQ 160
Score = 32.7 bits (73), Expect = 2.5
Identities = 37/141 (26%), Positives = 48/141 (34%), Gaps = 39/141 (27%)
Query: 1208 SRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREG--LWPPPYRPRRDAFEISTEGHS 1265
S PP P+ PP + G QP+ PP G PPP + +G
Sbjct: 172 SSRSPPGKPQG---------PPPQGGNQPQGPPPPPGKPQGPPPQGGNK------PQGPP 216
Query: 1266 GPSNRARWGPRG-ARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGP- 1323
P P+G +S + R+P G G QP PPP PG
Sbjct: 217 PPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQP-------------QGPPPPPGKP 263
Query: 1324 -------GRNPRGGLCPGYPE 1337
G P+G PG P+
Sbjct: 264 QGPPPQGGNKPQGPPPPGKPQ 284
Score = 32.7 bits (73), Expect = 2.5
Identities = 41/169 (24%), Positives = 57/169 (33%), Gaps = 50/169 (29%)
Query: 1206 PESRHHPPSNPRQQP----HLDSGSLPPGR-QGQQPR--------RDPPREGLWPPPY-- 1250
P+ PP P+ P + G PPG+ QG P+ R PP + PPP
Sbjct: 191 PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGG 250
Query: 1251 -----------RPRRDAFEISTEGHSGPSNRARWGP---RGARSHNPRNPASTAMGSSVP 1296
+P+ + + P GP G++S + R+P G
Sbjct: 251 NQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQ 310
Query: 1297 GYCQPITTVTASASVTVAVHPPPVPGP--------GRNPRGGLCPGYPE 1337
G QP PPP PG G P+G PG P+
Sbjct: 311 GGNQP-------------QGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ 346
>gi|224451135 splicing factor, arginine/serine-rich 15 isoform 3 [Homo
sapiens]
Length = 1125
Score = 42.4 bits (98), Expect = 0.003
Identities = 47/181 (25%), Positives = 64/181 (35%), Gaps = 41/181 (22%)
Query: 1116 PEVSPANGLNRLPTPSPEP----------PPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1165
P P L R P P P PP FAMPP H G + +
Sbjct: 840 PPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGM 899
Query: 1166 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1225
GL G GGP + + R PP P+QQP +
Sbjct: 900 PGLGGP------GPGPGGPEDR-------------------DGRQQPPQQPQQQPQPQAP 934
Query: 1226 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPR--GARSHNP 1283
P +Q QQP PP + P +P++ + + +SG ++ R+G R G R N
Sbjct: 935 QQPQQQQQQQP---PPSQQPPPTQQQPQQFRNDNRQQFNSG-RDQERFGRRSFGNRVEND 990
Query: 1284 R 1284
R
Sbjct: 991 R 991
>gi|224451133 splicing factor, arginine/serine-rich 15 isoform 2 [Homo
sapiens]
Length = 1132
Score = 42.4 bits (98), Expect = 0.003
Identities = 47/181 (25%), Positives = 64/181 (35%), Gaps = 41/181 (22%)
Query: 1116 PEVSPANGLNRLPTPSPEP----------PPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1165
P P L R P P P PP FAMPP H G + +
Sbjct: 847 PPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGM 906
Query: 1166 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1225
GL G GGP + + R PP P+QQP +
Sbjct: 907 PGLGGP------GPGPGGPEDR-------------------DGRQQPPQQPQQQPQPQAP 941
Query: 1226 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPR--GARSHNP 1283
P +Q QQP PP + P +P++ + + +SG ++ R+G R G R N
Sbjct: 942 QQPQQQQQQQP---PPSQQPPPTQQQPQQFRNDNRQQFNSG-RDQERFGRRSFGNRVEND 997
Query: 1284 R 1284
R
Sbjct: 998 R 998
>gi|40789229 splicing factor, arginine/serine-rich 15 isoform 1 [Homo
sapiens]
Length = 1147
Score = 42.4 bits (98), Expect = 0.003
Identities = 47/181 (25%), Positives = 64/181 (35%), Gaps = 41/181 (22%)
Query: 1116 PEVSPANGLNRLPTPSPEP----------PPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1165
P P L R P P P PP FAMPP H G + +
Sbjct: 862 PPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGM 921
Query: 1166 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1225
GL G GGP + + R PP P+QQP +
Sbjct: 922 PGLGGP------GPGPGGPEDR-------------------DGRQQPPQQPQQQPQPQAP 956
Query: 1226 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPR--GARSHNP 1283
P +Q QQP PP + P +P++ + + +SG ++ R+G R G R N
Sbjct: 957 QQPQQQQQQQP---PPSQQPPPTQQQPQQFRNDNRQQFNSG-RDQERFGRRSFGNRVEND 1012
Query: 1284 R 1284
R
Sbjct: 1013 R 1013
>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
tract binding protein associated) [Homo sapiens]
Length = 707
Score = 42.4 bits (98), Expect = 0.003
Identities = 43/151 (28%), Positives = 58/151 (38%), Gaps = 28/151 (18%)
Query: 1212 PPSNPRQQPHLDSGSLPPGRQG---QQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPS 1268
PP P QQ PP +Q Q P P + PPP P +D+ + GP+
Sbjct: 61 PPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPP--PPQDSSKPVVAQGPGPA 118
Query: 1269 NRARWGPRGARSHNPRNPAST----------------AMGSSVPGYCQPITTVTASASVT 1312
P + S P P ++ A+ S+ PG P T ++ T
Sbjct: 119 PGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPG-APPPTPPSSGVPTT 177
Query: 1313 V--AVHPPP----VPGPGRNPRGGLCPGYPE 1337
A PPP VPGPG P+ G PG P+
Sbjct: 178 PPQAGGPPPPPAAVPGPGPGPKQGPGPGGPK 208
Score = 33.1 bits (74), Expect = 1.9
Identities = 45/178 (25%), Positives = 55/178 (30%), Gaps = 23/178 (12%)
Query: 1114 PYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELR 1173
P P P P P P V + P S +S S + SG
Sbjct: 87 PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSG------ 140
Query: 1174 HYEAQQGAG-GPAHQVIVEATENPVFA-------HSTVVHPESRHHPPSNPRQQPHLDSG 1225
A G+G GP T P A P PP P P G
Sbjct: 141 ---APPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVP----G 193
Query: 1226 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNP 1283
P +QG P P+ G P +P + GH P +R PRG R H+P
Sbjct: 194 PGPGPKQGPGP--GGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHP 249
Score = 32.0 bits (71), Expect = 4.2
Identities = 55/226 (24%), Positives = 72/226 (31%), Gaps = 44/226 (19%)
Query: 1113 GPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEEL 1172
GP P + P + P P+ PP PP H + S+ +
Sbjct: 55 GPKPPIPPPPPHQQQQQPPPQQPPP----QQPPPHQPPPHPQPHQQQQPPPPPQDSSKPV 110
Query: 1173 RHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSN---PRQQPHLDSGSLPP 1229
QG GPA V + P + + P + PP + P P S PP
Sbjct: 111 ----VAQGP-GPAPGV---GSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPP 162
Query: 1230 GRQGQQPRRD-----PPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPR 1284
G P PP+ G PPP + G GP + GP G +
Sbjct: 163 GAPPPTPPSSGVPTTPPQAGGPPPP--------PAAVPG-PGPGPKQGPGPGGPK----- 208
Query: 1285 NPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGG 1330
G +PG +P S T HP P G PRGG
Sbjct: 209 -------GGKMPGGPKPGGGPGLS---TPGGHPKPPHRGGGEPRGG 244
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,264,918
Number of Sequences: 37866
Number of extensions: 2936119
Number of successful extensions: 13346
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 330
Number of HSP's that attempted gapping in prelim test: 12102
Number of HSP's gapped (non-prelim): 1383
length of query: 1381
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1266
effective length of database: 13,892,928
effective search space: 17588446848
effective search space used: 17588446848
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.