Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 134254435

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|134254435 patched isoform S [Homo sapiens]
         (1296 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|134254450 patched isoform S [Homo sapiens]                        2643   0.0  
gi|134254435 patched isoform S [Homo sapiens]                        2643   0.0  
gi|134254468 patched isoform S [Homo sapiens]                        2643   0.0  
gi|134254452 patched isoform S [Homo sapiens]                        2643   0.0  
gi|134254432 patched isoform L' [Homo sapiens]                       2643   0.0  
gi|134254466 patched isoform M [Homo sapiens]                        2643   0.0  
gi|134254446 patched isoform L [Homo sapiens]                        2643   0.0  
gi|52145305 patched 2 [Homo sapiens]                                 1167   0.0  
gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens]     130   6e-30
gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapi...   126   1e-28
gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapi...   110   1e-23
gi|239754873 PREDICTED: similar to hCG2040393 [Homo sapiens]           92   3e-18
gi|239749412 PREDICTED: hypothetical protein XP_002347031 [Homo ...    92   3e-18
gi|239743547 PREDICTED: hypothetical protein XP_002342883 [Homo ...    92   3e-18
gi|194018513 patched domain containing 3 [Homo sapiens]                84   7e-16
gi|148271104 patched domain containing 1 [Homo sapiens]                82   3e-15
gi|148277106 hypothetical protein LOC442213 [Homo sapiens]             79   2e-14
gi|66932902 SREBF chaperone protein [Homo sapiens]                     70   1e-11
gi|149274653 patched domain containing 2 [Homo sapiens]                53   2e-06
gi|25952134 dispatched A [Homo sapiens]                                50   1e-05
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    48   7e-05
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    48   7e-05
gi|150417989 cyclin K isoform 1 [Homo sapiens]                         45   5e-04
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre...    44   8e-04
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              44   0.001
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]     43   0.002
gi|224451135 splicing factor, arginine/serine-rich 15 isoform 3 ...    42   0.003
gi|224451133 splicing factor, arginine/serine-rich 15 isoform 2 ...    42   0.003
gi|40789229 splicing factor, arginine/serine-rich 15 isoform 1 [...    42   0.003
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin...    42   0.003

>gi|134254450 patched isoform S [Homo sapiens]
          Length = 1296

 Score = 2644 bits (6852), Expect = 0.0
 Identities = 1296/1296 (100%), Positives = 1296/1296 (100%)

Query: 1    MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60
            MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT
Sbjct: 1    MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60

Query: 61   ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120
            ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI
Sbjct: 61   ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120

Query: 121  NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180
            NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS
Sbjct: 121  NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180

Query: 181  RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240
            RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK
Sbjct: 181  RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240

Query: 241  AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300
            AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA
Sbjct: 241  AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300

Query: 301  YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360
            YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG
Sbjct: 301  YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360

Query: 361  VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420
            VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR
Sbjct: 361  VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420

Query: 421  AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480
            AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT
Sbjct: 421  AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480

Query: 481  DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540
            DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT
Sbjct: 481  DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540

Query: 541  VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600
            VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV
Sbjct: 541  VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600

Query: 601  VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660
            VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD
Sbjct: 601  VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660

Query: 661  YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720
            YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN
Sbjct: 661  YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720

Query: 721  NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780
            NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP
Sbjct: 721  NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780

Query: 781  VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840
            VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI
Sbjct: 781  VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840

Query: 841  EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900
            EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW
Sbjct: 841  EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900

Query: 901  TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960
            TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK
Sbjct: 901  TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960

Query: 961  NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
            NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL
Sbjct: 961  NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020

Query: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080
            PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV
Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080

Query: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140
            SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG
Sbjct: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140

Query: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200
            SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN
Sbjct: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200

Query: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260
            PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED
Sbjct: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260

Query: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296
            PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN
Sbjct: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296


>gi|134254435 patched isoform S [Homo sapiens]
          Length = 1296

 Score = 2644 bits (6852), Expect = 0.0
 Identities = 1296/1296 (100%), Positives = 1296/1296 (100%)

Query: 1    MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60
            MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT
Sbjct: 1    MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60

Query: 61   ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120
            ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI
Sbjct: 61   ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120

Query: 121  NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180
            NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS
Sbjct: 121  NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180

Query: 181  RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240
            RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK
Sbjct: 181  RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240

Query: 241  AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300
            AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA
Sbjct: 241  AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300

Query: 301  YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360
            YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG
Sbjct: 301  YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360

Query: 361  VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420
            VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR
Sbjct: 361  VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420

Query: 421  AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480
            AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT
Sbjct: 421  AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480

Query: 481  DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540
            DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT
Sbjct: 481  DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540

Query: 541  VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600
            VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV
Sbjct: 541  VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600

Query: 601  VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660
            VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD
Sbjct: 601  VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660

Query: 661  YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720
            YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN
Sbjct: 661  YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720

Query: 721  NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780
            NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP
Sbjct: 721  NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780

Query: 781  VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840
            VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI
Sbjct: 781  VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840

Query: 841  EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900
            EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW
Sbjct: 841  EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900

Query: 901  TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960
            TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK
Sbjct: 901  TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960

Query: 961  NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
            NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL
Sbjct: 961  NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020

Query: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080
            PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV
Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080

Query: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140
            SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG
Sbjct: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140

Query: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200
            SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN
Sbjct: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200

Query: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260
            PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED
Sbjct: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260

Query: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296
            PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN
Sbjct: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296


>gi|134254468 patched isoform S [Homo sapiens]
          Length = 1296

 Score = 2644 bits (6852), Expect = 0.0
 Identities = 1296/1296 (100%), Positives = 1296/1296 (100%)

Query: 1    MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60
            MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT
Sbjct: 1    MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60

Query: 61   ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120
            ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI
Sbjct: 61   ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120

Query: 121  NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180
            NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS
Sbjct: 121  NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180

Query: 181  RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240
            RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK
Sbjct: 181  RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240

Query: 241  AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300
            AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA
Sbjct: 241  AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300

Query: 301  YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360
            YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG
Sbjct: 301  YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360

Query: 361  VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420
            VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR
Sbjct: 361  VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420

Query: 421  AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480
            AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT
Sbjct: 421  AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480

Query: 481  DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540
            DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT
Sbjct: 481  DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540

Query: 541  VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600
            VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV
Sbjct: 541  VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600

Query: 601  VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660
            VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD
Sbjct: 601  VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660

Query: 661  YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720
            YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN
Sbjct: 661  YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720

Query: 721  NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780
            NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP
Sbjct: 721  NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780

Query: 781  VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840
            VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI
Sbjct: 781  VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840

Query: 841  EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900
            EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW
Sbjct: 841  EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900

Query: 901  TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960
            TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK
Sbjct: 901  TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960

Query: 961  NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
            NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL
Sbjct: 961  NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020

Query: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080
            PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV
Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080

Query: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140
            SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG
Sbjct: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140

Query: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200
            SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN
Sbjct: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200

Query: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260
            PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED
Sbjct: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260

Query: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296
            PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN
Sbjct: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296


>gi|134254452 patched isoform S [Homo sapiens]
          Length = 1296

 Score = 2644 bits (6852), Expect = 0.0
 Identities = 1296/1296 (100%), Positives = 1296/1296 (100%)

Query: 1    MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60
            MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT
Sbjct: 1    MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60

Query: 61   ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120
            ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI
Sbjct: 61   ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120

Query: 121  NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180
            NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS
Sbjct: 121  NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180

Query: 181  RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240
            RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK
Sbjct: 181  RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240

Query: 241  AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300
            AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA
Sbjct: 241  AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300

Query: 301  YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360
            YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG
Sbjct: 301  YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360

Query: 361  VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420
            VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR
Sbjct: 361  VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420

Query: 421  AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480
            AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT
Sbjct: 421  AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480

Query: 481  DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540
            DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT
Sbjct: 481  DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540

Query: 541  VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600
            VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV
Sbjct: 541  VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600

Query: 601  VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660
            VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD
Sbjct: 601  VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660

Query: 661  YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720
            YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN
Sbjct: 661  YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720

Query: 721  NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780
            NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP
Sbjct: 721  NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780

Query: 781  VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840
            VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI
Sbjct: 781  VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840

Query: 841  EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900
            EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW
Sbjct: 841  EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900

Query: 901  TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960
            TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK
Sbjct: 901  TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960

Query: 961  NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
            NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL
Sbjct: 961  NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020

Query: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080
            PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV
Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080

Query: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140
            SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG
Sbjct: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140

Query: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200
            SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN
Sbjct: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200

Query: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260
            PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED
Sbjct: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260

Query: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296
            PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN
Sbjct: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296


>gi|134254432 patched isoform L' [Homo sapiens]
          Length = 1446

 Score = 2644 bits (6852), Expect = 0.0
 Identities = 1296/1296 (100%), Positives = 1296/1296 (100%)

Query: 1    MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60
            MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT
Sbjct: 151  MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 210

Query: 61   ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120
            ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI
Sbjct: 211  ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 270

Query: 121  NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180
            NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS
Sbjct: 271  NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 330

Query: 181  RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240
            RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK
Sbjct: 331  RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 390

Query: 241  AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300
            AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA
Sbjct: 391  AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 450

Query: 301  YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360
            YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG
Sbjct: 451  YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 510

Query: 361  VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420
            VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR
Sbjct: 511  VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 570

Query: 421  AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480
            AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT
Sbjct: 571  AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 630

Query: 481  DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540
            DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT
Sbjct: 631  DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 690

Query: 541  VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600
            VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV
Sbjct: 691  VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 750

Query: 601  VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660
            VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD
Sbjct: 751  VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 810

Query: 661  YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720
            YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN
Sbjct: 811  YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 870

Query: 721  NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780
            NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP
Sbjct: 871  NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 930

Query: 781  VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840
            VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI
Sbjct: 931  VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 990

Query: 841  EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900
            EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW
Sbjct: 991  EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 1050

Query: 901  TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960
            TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK
Sbjct: 1051 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 1110

Query: 961  NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
            NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL
Sbjct: 1111 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1170

Query: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080
            PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV
Sbjct: 1171 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1230

Query: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140
            SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG
Sbjct: 1231 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1290

Query: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200
            SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN
Sbjct: 1291 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1350

Query: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260
            PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED
Sbjct: 1351 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1410

Query: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296
            PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN
Sbjct: 1411 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1446


>gi|134254466 patched isoform M [Homo sapiens]
          Length = 1381

 Score = 2644 bits (6852), Expect = 0.0
 Identities = 1296/1296 (100%), Positives = 1296/1296 (100%)

Query: 1    MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60
            MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT
Sbjct: 86   MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 145

Query: 61   ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120
            ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI
Sbjct: 146  ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 205

Query: 121  NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180
            NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS
Sbjct: 206  NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 265

Query: 181  RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240
            RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK
Sbjct: 266  RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 325

Query: 241  AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300
            AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA
Sbjct: 326  AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 385

Query: 301  YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360
            YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG
Sbjct: 386  YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 445

Query: 361  VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420
            VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR
Sbjct: 446  VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 505

Query: 421  AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480
            AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT
Sbjct: 506  AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 565

Query: 481  DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540
            DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT
Sbjct: 566  DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 625

Query: 541  VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600
            VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV
Sbjct: 626  VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 685

Query: 601  VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660
            VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD
Sbjct: 686  VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 745

Query: 661  YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720
            YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN
Sbjct: 746  YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 805

Query: 721  NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780
            NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP
Sbjct: 806  NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 865

Query: 781  VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840
            VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI
Sbjct: 866  VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 925

Query: 841  EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900
            EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW
Sbjct: 926  EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 985

Query: 901  TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960
            TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK
Sbjct: 986  TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 1045

Query: 961  NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
            NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL
Sbjct: 1046 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1105

Query: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080
            PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV
Sbjct: 1106 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1165

Query: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140
            SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG
Sbjct: 1166 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1225

Query: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200
            SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN
Sbjct: 1226 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1285

Query: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260
            PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED
Sbjct: 1286 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1345

Query: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296
            PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN
Sbjct: 1346 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1381


>gi|134254446 patched isoform L [Homo sapiens]
          Length = 1447

 Score = 2644 bits (6852), Expect = 0.0
 Identities = 1296/1296 (100%), Positives = 1296/1296 (100%)

Query: 1    MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60
            MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT
Sbjct: 152  MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 211

Query: 61   ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120
            ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI
Sbjct: 212  ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 271

Query: 121  NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180
            NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS
Sbjct: 272  NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 331

Query: 181  RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240
            RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK
Sbjct: 332  RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 391

Query: 241  AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300
            AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA
Sbjct: 392  AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 451

Query: 301  YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360
            YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG
Sbjct: 452  YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 511

Query: 361  VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420
            VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR
Sbjct: 512  VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 571

Query: 421  AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480
            AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT
Sbjct: 572  AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 631

Query: 481  DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540
            DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT
Sbjct: 632  DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 691

Query: 541  VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600
            VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV
Sbjct: 692  VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 751

Query: 601  VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660
            VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD
Sbjct: 752  VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 811

Query: 661  YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720
            YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN
Sbjct: 812  YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 871

Query: 721  NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780
            NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP
Sbjct: 872  NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 931

Query: 781  VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840
            VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI
Sbjct: 932  VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 991

Query: 841  EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900
            EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW
Sbjct: 992  EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 1051

Query: 901  TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960
            TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK
Sbjct: 1052 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 1111

Query: 961  NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
            NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL
Sbjct: 1112 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1171

Query: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080
            PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV
Sbjct: 1172 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1231

Query: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140
            SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG
Sbjct: 1232 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1291

Query: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200
            SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN
Sbjct: 1292 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1351

Query: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260
            PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED
Sbjct: 1352 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1411

Query: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296
            PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN
Sbjct: 1412 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1447


>gi|52145305 patched 2 [Homo sapiens]
          Length = 1203

 Score = 1167 bits (3018), Expect = 0.0
 Identities = 580/1035 (56%), Positives = 761/1035 (73%), Gaps = 27/1035 (2%)

Query: 2    FNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITE 61
            +  Q++IQT ++EG N+LT EAL  HL +AL AS+V V +Y + W L  +CYKSG  + E
Sbjct: 110  YTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIE 169

Query: 62   TGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKIN 121
             G ++++IE L+PC+I+TPLDCFWEGAKLQ G+AYL G+P ++WTN DP + LEEL    
Sbjct: 170  NGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFA 229

Query: 122  YQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSR 181
              ++ + E+L+KA+VG  Y+ RPCL+P D  CP +APN +S +  ++A  L+GGCHG S 
Sbjct: 230  -SLEGFRELLDKAQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSH 288

Query: 182  KYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKA 241
            K+MHWQEEL++GG  ++  G+L+ A ALQ+ F LM+P+Q+YEHF+G      I W+E++A
Sbjct: 289  KFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQA 348

Query: 242  AAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAY 301
            + +L+AWQR +V++  +++ +N++Q++ +F++TTLDDIL +FS+VS  RV  GYLLMLAY
Sbjct: 349  STVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAY 408

Query: 302  ACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGV 361
            AC+TMLRWDC++SQG+VGLAGVLLVAL+VA+GLGLC+L+GI+FNAATTQVLPFLALG+GV
Sbjct: 409  ACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGV 468

Query: 362  DDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRA 421
            DDVFLLAHAF+E       P ++R GECL+RTG SV LTSI+N+ AF MAAL+PIPALRA
Sbjct: 469  DDVFLLAHAFTEALPG--TPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRA 526

Query: 422  FSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTD 481
            FSLQAA+VV   F  V+L+FPAILS+DL RR  +RLD+ CCF+SPC ++VIQ+ PQ   D
Sbjct: 527  FSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGD 586

Query: 482  THDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTV 541
                      P   +H         + +TVQ  T  +  +    T   P++ +   P   
Sbjct: 587  -------GTVPVGIAH---------LTATVQAFTHCEASSQHVVTILPPQAHLVPPP--- 627

Query: 542  TQDTLSCQSPESTSSTRDLLSQFSDS--SLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAK 599
              D L  +      STRDLL Q  ++     C   PC +W L+ FA   +AP LL+  AK
Sbjct: 628  -SDPLGSELFSPGGSTRDLLGQEEETRQKAACKSLPCARWNLAHFARYQFAPLLLQSHAK 686

Query: 600  VVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKA 659
             +V+ LF  LLG+SLYG T V+DGL LTD+VPR T+E+ F++AQ +YFS Y + +VTQ  
Sbjct: 687  AIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGG 746

Query: 660  -DYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIM 718
             DY + Q  L+DLH+ FS++K V+     Q P+ WLHY+R+WLQG+Q AFD DW +G+I 
Sbjct: 747  FDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRNWLQGIQAAFDQDWASGRIT 806

Query: 719  PNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSN 778
             ++Y+NGS+DG LAYKLL+QTG   +P+D SQLT ++LVD +G+I P  FY+ LT WVS+
Sbjct: 807  RHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDREGLIPPELFYMGLTVWVSS 866

Query: 779  DPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVE 838
            DP+  AASQAN  P  PEW+HDK D   E  LRIP A+P+E+AQFPF L GL+ T+DFVE
Sbjct: 867  DPLGLAASQANFYPPPPEWLHDKYDTTGE-NLRIPPAQPLEFAQFPFLLRGLQKTADFVE 925

Query: 839  AIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLN 898
            AIE  R  C+     G+ +YP+G PFLFWEQY+GLR   LL + ++L CTFLVCA+ LLN
Sbjct: 926  AIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLN 985

Query: 899  PWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIG 958
            PWTAG+IV+VLA+MTVELFG+MG +GIKLSA+PVVIL+ASVGIGVEFTVHVAL FLT  G
Sbjct: 986  PWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQG 1045

Query: 959  DKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLV 1018
             +N RA  ALEH FAPV DGA+STLLG+LMLAGS FDFIVRYFFA L +LT+LG+L+GLV
Sbjct: 1046 SRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLV 1105

Query: 1019 LLPVLLSFFGPYPEV 1033
            LLPVLLS  GP PEV
Sbjct: 1106 LLPVLLSILGPPPEV 1120



 Score = 31.2 bits (69), Expect = 6.7
 Identities = 16/35 (45%), Positives = 22/35 (62%), Gaps = 5/35 (14%)

Query: 1208 SSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1242
            SS+P     +TT     S+TVA+HPPP+PG   +P
Sbjct: 1147 SSLPQSFARVTT-----SMTVAIHPPPLPGAYIHP 1176


>gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens]
          Length = 1278

 Score =  130 bits (328), Expect = 6e-30
 Identities = 126/476 (26%), Positives = 214/476 (44%), Gaps = 66/476 (13%)

Query: 581  LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
            L  F +  Y+P LLK   + +VI +F+G+L  S+    +V  GLD +  +P ++   D+ 
Sbjct: 817  LFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYF 876

Query: 641  AAQFKYF-SFYNMYIVTQKA-DYP--------------NIQHLLYDLHRSFSNVKYVMLE 684
             +  +Y  +   +Y V ++  DY               N   L+  +  +     Y  + 
Sbjct: 877  KSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIG 936

Query: 685  ENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGS--DDGVLAYKLLVQTGSR 742
                 P  W+  + DW++        D  T     + + N S  D   +  + L   G  
Sbjct: 937  F---APSSWIDDYFDWVKPQSSCCRVDNIT-----DQFCNASVVDPACVRCRPLTPEG-- 986

Query: 743  DKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKA 802
                      KQR    D       F  +L  ++S++P           P   +  H  A
Sbjct: 987  ----------KQRPQGGD-------FMRFLPMFLSDNP----------NPKCGKGGH--A 1017

Query: 803  DYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSS---- 857
             Y     + +     +    F  Y   L+ ++DF++A++K R I SN T ++G++     
Sbjct: 1018 AYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYR 1077

Query: 858  -YPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFL-LNPWTAGIIVMVLALMTVE 915
             +P    ++F+EQY+ +    +  + V L   FLV  V L    W+A I+   +A++ V 
Sbjct: 1078 VFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVN 1137

Query: 916  LFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAI-GDKNRRAVLALEHMFAP 974
            +FG+M L GI L+AV +V L+ S GI VEF  H+  AF  ++ G +  RA  AL HM + 
Sbjct: 1138 MFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSS 1197

Query: 975  VLDGAVSTLL-GVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
            V  G   T   G+++LA ++      ++F +   + +LG  +GL+ LPVLLS+ GP
Sbjct: 1198 VFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGP 1253



 Score =  130 bits (326), Expect = 1e-29
 Identities = 77/233 (33%), Positives = 123/233 (52%), Gaps = 9/233 (3%)

Query: 236 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASG 294
           +N+ +     +AW++ ++  V      N T   +SFT   +++D L   SD  V  V   
Sbjct: 571 YNDTEKLQRAQAWEKEFINFVKNYKNPNLT---ISFTAERSIEDELNRESDSDVFTVVIS 627

Query: 295 YLLMLAYACLTM-----LRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATT 349
           Y +M  Y  L +      R     S+ ++G+AG+L+V  SVA  LG+ S IG+       
Sbjct: 628 YAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVI 687

Query: 350 QVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFF 409
           +V+PFL L VGVD++F+L  A+    + +    + + G  L     S+ L+S S   AFF
Sbjct: 688 EVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFF 747

Query: 410 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 462
           + AL  +PA+  FSL A + V  +F + +  F ++L +D+ R+E  RLDIFCC
Sbjct: 748 LGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC 800


>gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapiens]
          Length = 1332

 Score =  126 bits (317), Expect = 1e-28
 Identities = 140/544 (25%), Positives = 236/544 (43%), Gaps = 96/544 (17%)

Query: 581  LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
            L  F +K YAPFLL    + VV+ LFL L GVSLY    +  GLD    +P+++   D+ 
Sbjct: 828  LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYF 887

Query: 641  AAQFKYFSF-----------YN------MYIVTQKADYPNI---QHLLYDLHRSFSNVKY 680
                +YF             YN      M  +   A   N    Q + Y     F    Y
Sbjct: 888  LFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATE--FPEQSY 945

Query: 681  VMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTG 740
            + +  +      W+  F DWL                 P++            +L +   
Sbjct: 946  LAIPASS-----WVDDFIDWLT----------------PSS----------CCRLYISGP 974

Query: 741  SRDK--PIDISQLT--KQRLVDADGIINPSA--FYIYLTAWVSNDPVAYAASQANIRPHR 794
            ++DK  P  ++ L   K  +    G + PS   F+ YL  W  ND       +  +  + 
Sbjct: 975  NKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLP-WFLNDRPNIKCPKGGLAAY- 1032

Query: 795  PEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTS-- 852
                         T + + +   +  ++F  Y   L+++ D+ EA+   R + +N T+  
Sbjct: 1033 ------------STSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL 1080

Query: 853  -------LGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGII 905
                        +P     +F+EQY+ +    L  +S+ L  TF V  + L     +G++
Sbjct: 1081 RKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLL 1140

Query: 906  -VMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKN--- 961
             ++ + ++ V+  G M L GI  +AV ++ L+++VG+ VEF  H+  +F  AI  K    
Sbjct: 1141 NLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSF--AISTKPTWL 1198

Query: 962  RRAVLALEHMFAPVLDG-AVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020
             RA  A   M + V  G A++ L G+L+L  ++   I  +FF +  ++T+LG+L+GLV L
Sbjct: 1199 ERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFL 1258

Query: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTH--SGSDSSDSEYSSQT 1078
            PV+LS+ G  P+V+PA  L +      E   + V  A  P H    S +D+    +S + 
Sbjct: 1259 PVILSYVG--PDVNPALALEQ---KRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEG 1313

Query: 1079 TVSG 1082
            ++ G
Sbjct: 1314 SIKG 1317



 Score =  110 bits (274), Expect = 1e-23
 Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 6/230 (2%)

Query: 239 DKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASGYLL 297
           D   A  + W+  ++E +     + +    ++F    +L+D +   +   +   A+ Y++
Sbjct: 583 DPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIV 642

Query: 298 MLAYACLTMLRWDCSK-----SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVL 352
           +  Y  L +  +         S+  +GL GV +V  +V A +G  S +GI  +    QV+
Sbjct: 643 IFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVV 702

Query: 353 PFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA 412
           PFL L VG D++F+    +    +    P E   G  L R   S+ L S+S    FF+ A
Sbjct: 703 PFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGA 762

Query: 413 LIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 462
           L P+PA+R F+L + + V+ +F + +  F A+LS+D  R+E  RLD+ CC
Sbjct: 763 LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812


>gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo
           sapiens]
          Length = 1359

 Score =  110 bits (274), Expect = 1e-23
 Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 6/230 (2%)

Query: 239 DKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASGYLL 297
           D   A  + W+  ++E +     + +    ++F    +L+D +   +   +   A+ Y++
Sbjct: 583 DPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIV 642

Query: 298 MLAYACLTMLRWDCSK-----SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVL 352
           +  Y  L +  +         S+  +GL GV +V  +V A +G  S +GI  +    QV+
Sbjct: 643 IFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVV 702

Query: 353 PFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA 412
           PFL L VG D++F+    +    +    P E   G  L R   S+ L S+S    FF+ A
Sbjct: 703 PFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGA 762

Query: 413 LIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 462
           L P+PA+R F+L + + V+ +F + +  F A+LS+D  R+E  RLD+ CC
Sbjct: 763 LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812



 Score =  103 bits (256), Expect = 1e-21
 Identities = 82/278 (29%), Positives = 144/278 (51%), Gaps = 23/278 (8%)

Query: 821  AQFPFYLNGLRDTSDFVEAIEKVRTICSNYTS---------LGLSSYPNGYPFLFWEQYI 871
            ++F  Y   L+++ D+ EA+   R + +N T+              +P     +F+EQY+
Sbjct: 1074 SRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYL 1133

Query: 872  GLRHWLLLFISVVLACTFLVCAVFLLNPWTAGII-VMVLALMTVELFGMMGLIGIKLSAV 930
             +    L  +S+ L  TF V  + L     +G++ ++ + ++ V+  G M L GI  +AV
Sbjct: 1134 TILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAV 1193

Query: 931  PVVILIASVGIGVEFTVHVALAFLTAIGDKN---RRAVLALEHMFAPVLDG-AVSTLLGV 986
             ++ L+++VG+ VEF  H+  +F  AI  K     RA  A   M + V  G A++ L G+
Sbjct: 1194 SLINLVSAVGMSVEFVSHITRSF--AISTKPTWLERAKEATISMGSAVFAGVAMTNLPGI 1251

Query: 987  LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPS 1046
            L+L  ++   I  +FF +  ++T+LG+L+GLV LPV+LS+ G  P+V+PA  L +     
Sbjct: 1252 LVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVG--PDVNPALALEQ---KR 1306

Query: 1047 PEPPPSVVRFAMPPGHTH--SGSDSSDSEYSSQTTVSG 1082
             E   + V  A  P H    S +D+    +S + ++ G
Sbjct: 1307 AEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEGSIKG 1344



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 27/67 (40%), Positives = 37/67 (55%)

Query: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
           L  F +K YAPFLL    + VV+ LFL L GVSLY    +  GLD    +P+++   D+ 
Sbjct: 828 LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYF 887

Query: 641 AAQFKYF 647
               +YF
Sbjct: 888 LFLNRYF 894


>gi|239754873 PREDICTED: similar to hCG2040393 [Homo sapiens]
          Length = 333

 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 93/295 (31%), Positives = 113/295 (38%), Gaps = 52/295 (17%)

Query: 1035 PANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQ 1094
            P +   R   P P  P S  R    PG    GS      +     +   +   RH +   
Sbjct: 58   PGHTAPRTQQPKPSGPSSHPREPPLPGAVTGGS----LHFQEPPPLGAATAGSRHRQKPP 113

Query: 1095 GAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPS---NPRQQPHL-DSGSLPPGRQGQQ 1150
              G           E P    +T      R  PPS         HL  SGS    R    
Sbjct: 114  SPGSR------HRWEPPPPGAATATGSRHRREPPSPGATTAGSCHLRSSGSTGTRRAPSH 167

Query: 1151 PR-------RDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWG---PRGARSHNP-- 1198
            P        R+ PRE    PP  P+  A     EG S       WG   P+G R      
Sbjct: 168  PAALQVPYTREGPREPT--PPAGPQGFAGSFCAEG-SRRGAEVGWGKLEPQGTRRTGSLG 224

Query: 1199 --RNPASTAMGSSVPG------------YCQPITTVTASASVTVAVHPPPVPGPGRNPRG 1244
               +P S  +G +  G            +C  I       +      P   PGP ++P+ 
Sbjct: 225  VDSSPLSETLGPAQCGSGRRRACSVLHHHCDGIRFRDCHCA------PSACPGPTQDPQA 278

Query: 1245 GLCPG---YPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296
            GLC G   YP TDHGLF  PH+ F V+ ER + KVEV ELQDVECEE PRGSSSN
Sbjct: 279  GLCTGQEGYPGTDHGLFMGPHLLFQVQGERTNLKVEVTELQDVECEEWPRGSSSN 333


>gi|239749412 PREDICTED: hypothetical protein XP_002347031 [Homo
            sapiens]
          Length = 333

 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 93/295 (31%), Positives = 113/295 (38%), Gaps = 52/295 (17%)

Query: 1035 PANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQ 1094
            P +   R   P P  P S  R    PG    GS      +     +   +   RH +   
Sbjct: 58   PGHTAPRTQQPKPSGPSSHPREPPLPGAVTGGS----LHFQEPPPLGAATAGSRHRQKPP 113

Query: 1095 GAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPS---NPRQQPHL-DSGSLPPGRQGQQ 1150
              G           E P    +T      R  PPS         HL  SGS    R    
Sbjct: 114  SPGSR------HRWEPPPPGAATATGSRHRREPPSPGATTAGSCHLRSSGSTGTRRAPSH 167

Query: 1151 PR-------RDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWG---PRGARSHNP-- 1198
            P        R+ PRE    PP  P+  A     EG S       WG   P+G R      
Sbjct: 168  PAALQVPYTREGPREPT--PPAGPQGFAGSFCAEG-SRRGAEVGWGKLEPQGTRRTGSLG 224

Query: 1199 --RNPASTAMGSSVPG------------YCQPITTVTASASVTVAVHPPPVPGPGRNPRG 1244
               +P S  +G +  G            +C  I       +      P   PGP ++P+ 
Sbjct: 225  VDSSPLSETLGPAQCGSGRRRACSVLHHHCDGIRFRDCHCA------PSACPGPTQDPQA 278

Query: 1245 GLCPG---YPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296
            GLC G   YP TDHGLF  PH+ F V+ ER + KVEV ELQDVECEE PRGSSSN
Sbjct: 279  GLCTGQEGYPGTDHGLFMGPHLLFQVQGERTNLKVEVTELQDVECEEWPRGSSSN 333


>gi|239743547 PREDICTED: hypothetical protein XP_002342883 [Homo
            sapiens]
          Length = 333

 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 93/295 (31%), Positives = 113/295 (38%), Gaps = 52/295 (17%)

Query: 1035 PANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQ 1094
            P +   R   P P  P S  R    PG    GS      +     +   +   RH +   
Sbjct: 58   PGHTAPRTQQPKPSGPSSHPREPPLPGAVTGGS----LHFQEPPPLGAATAGSRHRQKPP 113

Query: 1095 GAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPS---NPRQQPHL-DSGSLPPGRQGQQ 1150
              G           E P    +T      R  PPS         HL  SGS    R    
Sbjct: 114  SPGSR------HRWEPPPPGAATATGSRHRREPPSPGATTAGSCHLRSSGSTGTRRAPSH 167

Query: 1151 PR-------RDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWG---PRGARSHNP-- 1198
            P        R+ PRE    PP  P+  A     EG S       WG   P+G R      
Sbjct: 168  PAALQVPYTREGPREPT--PPAGPQGFAGSFCAEG-SRRGAEVGWGKLEPQGTRRTGSLG 224

Query: 1199 --RNPASTAMGSSVPG------------YCQPITTVTASASVTVAVHPPPVPGPGRNPRG 1244
               +P S  +G +  G            +C  I       +      P   PGP ++P+ 
Sbjct: 225  VDSSPLSETLGPAQCGSGRRRACSVLHHHCDGIRFRDCHCA------PSACPGPTQDPQA 278

Query: 1245 GLCPG---YPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296
            GLC G   YP TDHGLF  PH+ F V+ ER + KVEV ELQDVECEE PRGSSSN
Sbjct: 279  GLCTGQEGYPGTDHGLFMGPHLLFQVQGERTNLKVEVTELQDVECEEWPRGSSSN 333


>gi|194018513 patched domain containing 3 [Homo sapiens]
          Length = 767

 Score = 84.3 bits (207), Expect = 7e-16
 Identities = 62/246 (25%), Positives = 120/246 (48%), Gaps = 20/246 (8%)

Query: 203 LVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQ 262
           L+ A A++ ++ L T    Y+  +  ++++H+    D+   I        +EVVH +   
Sbjct: 316 LLRAKAMRLLYYLKTEDPEYD-VQSKQWLTHLL---DQFTNIKNILALKKIEVVHFT--- 368

Query: 263 NSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAG 322
            S  + L F  T       S + + V  +A  Y+L++ +A  +  R+DC +++  V   G
Sbjct: 369 -SLSRQLEFEAT-------SVTVIPVFHLA--YILIILFAVTSCFRFDCIRNKMCVAAFG 418

Query: 323 VLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPF 382
           V+   L+V +G GL   IG+ F        PFL LGVGVDD+F++  A+ +T  N     
Sbjct: 419 VISAFLAVVSGFGLLLHIGVPFVIIVAN-SPFLILGVGVDDMFIMISAWHKT--NLADDI 475

Query: 383 EDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFP 442
            +R      +   S+ +T+I+N+ A +   +    +++ F +   + ++F +   +  F 
Sbjct: 476 RERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFG 535

Query: 443 AILSMD 448
           A +++D
Sbjct: 536 AFMALD 541



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 37/128 (28%), Positives = 68/128 (53%), Gaps = 9/128 (7%)

Query: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
           +S F   ++ PFL + ++K  V+F+++  +  S+YG   V++GLDL ++   ++    + 
Sbjct: 584 ISLFFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYF 643

Query: 641 AAQFKYFSFYN---MYIVTQKADY--PNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH 695
             +  YFS Y    M IVT+K DY   +++  L +  + F    YV    +K L + WL 
Sbjct: 644 NVEENYFSDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYV----DKNLTEFWLD 699

Query: 696 YFRDWLQG 703
            +  +L+G
Sbjct: 700 AYVQYLKG 707


>gi|148271104 patched domain containing 1 [Homo sapiens]
          Length = 888

 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 65/272 (23%), Positives = 126/272 (46%), Gaps = 24/272 (8%)

Query: 192 VGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRT 251
           +GG   +S  ++ SA A+Q  +                Y+  IN   D  A   E W+ +
Sbjct: 192 LGGVTVHSKDRVKSAEAIQLTY----------------YLQSINSLNDMVA---ERWESS 232

Query: 252 YVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDC 311
           + + V      NS  K+  +T+++L +  +  S VS   + +  +L++  A L     DC
Sbjct: 233 FCDTVRLFQKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDC 292

Query: 312 SKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF 371
            +S+  +GL G++ ++L+     G+ +L G  +N +T   +PF+ LG G+   F +  ++
Sbjct: 293 VRSKPWLGLLGLVTISLATLTAAGIINLTGGKYN-STFLGVPFVMLGHGLYGTFEMLSSW 351

Query: 372 SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFSLQAAVV 429
            +T +++ +  ++RT      +  S +LT+   +  F + A     I A R F   + + 
Sbjct: 352 RKTREDQHV--KERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIA 409

Query: 430 VVFNFAMVLLIFPAILSMDLYRREDRRLDIFC 461
           + FN+  VL  + + L    Y   + +  IFC
Sbjct: 410 IFFNYLYVLSFYGSSLVFTGYIENNYQHSIFC 441



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 23/74 (31%), Positives = 40/74 (54%)

Query: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
           L  F +++Y  ++     K  V+  +L  +  +L G  +V +G DL++IV   T+  ++ 
Sbjct: 483 LVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYT 542

Query: 641 AAQFKYFSFYNMYI 654
            AQ KYFS Y+  I
Sbjct: 543 TAQQKYFSNYSPVI 556



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 36/155 (23%), Positives = 66/155 (42%), Gaps = 16/155 (10%)

Query: 878  LLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVE--LFGMMGLIGIKLSAVPVVIL 935
            LLF S  L       A  L+N W      + L +++VE  + G M L  ++L  + V+ L
Sbjct: 710  LLFFSAFLV------ADSLINVW------ITLTVVSVEFGVIGFMTLWKVELDCISVLCL 757

Query: 936  IASVGIGVEFTVHVALAFLTAIGDKNRRAVL-ALEHMFAPVLDGAVSTLLGVLMLAGSEF 994
            I  +   ++    +   F+        + V  ALE     +L   +  ++G++ LA    
Sbjct: 758  IYGINYTIDNCAPMLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLIPLAAVPS 817

Query: 995  DFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
            +      F  L ++  +   +   +LPV+L+F  P
Sbjct: 818  NLTCT-LFRCLFLIAFVTFFHCFAILPVILTFLPP 851


>gi|148277106 hypothetical protein LOC442213 [Homo sapiens]
          Length = 829

 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 62/260 (23%), Positives = 112/260 (43%), Gaps = 7/260 (2%)

Query: 246 EAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLT 305
           E W+  + +++ +   ++   ++ S  + +L       S ++  +V    +L+L  A L+
Sbjct: 175 EKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLS 234

Query: 306 MLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVF 365
               DC +S+  +GL GVL V +S+    G+  +    +N +T   +PF A+G G   VF
Sbjct: 235 SSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYN-STLLGIPFFAMGHGTKGVF 293

Query: 366 LLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFS 423
            L   +  T +N  +PF+DR  +       +  +TS      F M A     I A++ F 
Sbjct: 294 ELLSGWRRTKEN--LPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFC 351

Query: 424 LQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF--TSPCVSRVIQVEPQAYTD 481
               V ++ N+  +   F + L       ++R   IFCC   ++  + R         +D
Sbjct: 352 QNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSD 411

Query: 482 THDNTRYSPPPPYSSHSFAH 501
            H  T +    PY  H   H
Sbjct: 412 GHQQTSHHETNPYQHHFIQH 431



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 43/183 (23%), Positives = 84/183 (45%), Gaps = 9/183 (4%)

Query: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
           +  F  +HY  ++     K  V+ L+L     S  G  ++ DG ++ +++  ++    + 
Sbjct: 429 IQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYA 488

Query: 641 AAQFKYFSFYNMYI---VTQKADYPN--IQHLLYDLHRSFSNVKYV-MLEENKQLPKMWL 694
             Q KYFS Y+  I   V +  +Y N  +Q  L  L   F+ V +V    +  ++  +  
Sbjct: 489 MVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSA 548

Query: 695 HYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKL-LVQTGSRDKPIDISQL 751
           +   D++  LQ +F    E      +    K G +  ++A +L LV   SRDK  +I+++
Sbjct: 549 NNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEV 608

Query: 752 TKQ 754
            ++
Sbjct: 609 LEK 611



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 39/174 (22%), Positives = 78/174 (44%), Gaps = 12/174 (6%)

Query: 865  LFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTA----GIIVMVLALMTVEL--FG 918
            +F   ++ + H+ L     VL   F V  V +L  +      G   ++L++ ++EL   G
Sbjct: 625  VFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLG 684

Query: 919  MMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLA-LEHMFAPVLD 977
            +M L  + +  + ++ LI ++   ++    +   F+ A      + + + L+     +L 
Sbjct: 685  LMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQ 744

Query: 978  GAVSTLLGV--LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
               S L+G+  L+   S   F +   F  L +     +L+  V+LPV L+FF P
Sbjct: 745  NVTSFLIGLVPLLFVPSNLTFTL---FKCLLLTGGCTLLHCFVILPVFLTFFPP 795


>gi|66932902 SREBF chaperone protein [Homo sapiens]
          Length = 1279

 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 45/182 (24%), Positives = 90/182 (49%), Gaps = 6/182 (3%)

Query: 288 VIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAA 347
           +I + + Y+++ AY   +  + D  KS+  + LA V+ V  S+   +GLC+L G++    
Sbjct: 285 LIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLN 344

Query: 348 TTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTA 407
             ++ P+L + +G+++V +L  +   T  +  +    R  + L     S+     + +  
Sbjct: 345 GGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKL--RIAQGLSSESWSIMKNMATELGI 402

Query: 408 FFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRRE----DRRLDIFCCF 463
             +     +PA++ F L A V +V +F + +L F  +LS+D+ R E    ++RL    C 
Sbjct: 403 ILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACL 462

Query: 464 TS 465
            S
Sbjct: 463 PS 464


>gi|149274653 patched domain containing 2 [Homo sapiens]
          Length = 1392

 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 87/394 (22%), Positives = 152/394 (38%), Gaps = 65/394 (16%)

Query: 236 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGY 295
           W E +A    +++  TYV ++    A+ ST KV      T         D  V R  +  
Sbjct: 415 WEEQRAK--FQSFVVTYVAML----AKQSTSKVQVLYGGT------DLFDYEVRRTFNND 462

Query: 296 LLM--LAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLI-GISFNAATTQVL 352
           +L+  ++ +C+  L +  +     +   G+  + LS    L L  ++ GI +      V 
Sbjct: 463 MLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVA 522

Query: 353 PFLALGVGVDDVFLLAHAFSETGQNKRIPFED---RTGECLKRTGASVALTSISNVTAFF 409
            F+ +G+GVDDVF+  + + +         ED   R    ++  G +   TS++   A+ 
Sbjct: 523 AFVIVGIGVDDVFVFINTYRQATH-----LEDPQLRMIHTVQTAGKATFFTSLTTAAAYA 577

Query: 410 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVS 469
                 IPA+  F L  +++V   +  VL+  PA L +            +  + +P   
Sbjct: 578 ANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL------------WSLYLAP--- 622

Query: 470 RVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAE 529
               +E    T  H N        +    FA   Q+            D    +     E
Sbjct: 623 ----LESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEE 678

Query: 530 PRS-EIS-VQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEK 587
           P S E+  V  V+V+ + L  Q   +T S   L+ Q  +   H        W L S    
Sbjct: 679 PVSLELGDVSLVSVSPEGL--QPASNTGSRGHLIVQLQELLHH--------WVLWSAV-- 726

Query: 588 HYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVR 621
                    K++ V++ LF+ +L +SL   +R+R
Sbjct: 727 ---------KSRWVIVGLFVSILILSLVFASRLR 751



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 35/167 (20%), Positives = 67/167 (40%), Gaps = 39/167 (23%)

Query: 877  LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 936
            +LL + V+L+   +VC V  +  W+                      G ++ AV  + L 
Sbjct: 1205 ILLLLPVLLSILGIVCLVVTIMYWS----------------------GWEMGAVEAISLS 1242

Query: 937  ASVGIGVEFTVHVALAFL------------TAIGDKNRRAVLALEHMFAPVLDGAVSTLL 984
              VG  V++ VH+   +L             A   +  R + A+ H+   ++  A++T++
Sbjct: 1243 ILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVI 1302

Query: 985  GVLMLAGSEFDFIVRY--FFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
              + L    F  I  +  F  ++A+ T + +L  L +   LL    P
Sbjct: 1303 ATVPLF---FCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAP 1346


>gi|25952134 dispatched A [Homo sapiens]
          Length = 1524

 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 29/113 (25%), Positives = 55/113 (48%), Gaps = 5/113 (4%)

Query: 355 LALGVGVDDVFLLAHAFSETGQNK-RIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL 413
           + +G+G DD F+L   ++ T  +K      +     L+    S+ +TS +   AF+   +
Sbjct: 565 ILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYV 624

Query: 414 IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSP 466
             I A+R F + A   ++ N+ +++   PA++ +     E   L+IF CF  P
Sbjct: 625 SNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKP 673



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 41/173 (23%), Positives = 79/173 (45%), Gaps = 21/173 (12%)

Query: 836  FVEAIEKVRTI---CSNYTSLGLSSYPNGYP-------FLFWEQYIGLRHWLLLFISVVL 885
            F  A EK+        ++ S  LSS P G           F++    L    L+ + + +
Sbjct: 933  FTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSV 992

Query: 886  ACTFLVCAVFLLNPWTAGIIVMVLALMTVE-----LFGMMGLIGIKLSAVPVVILIASVG 940
            A  F   +V LL  W   II+ + A++++        G + L+G +L+ +  V +  +VG
Sbjct: 993  AVAF---SVMLLTTWN--IIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVG 1047

Query: 941  IGVEFTVHVALAF-LTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGS 992
            + V+F VH  +A+ L    D+  + + +L  + + +   A++T +   M+  S
Sbjct: 1048 LSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 1100


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 855

 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 67/245 (27%), Positives = 89/245 (36%), Gaps = 32/245 (13%)

Query: 1027 FGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEE 1086
            F P P +SP      L TP P+ PP++   A+PP      S  +    S   T S  +  
Sbjct: 380  FLPSPPLSP------LATPPPQAPPAL---ALPPLQA-PPSPPASPPLSPLATPSPQAPN 429

Query: 1087 LRHYEAQQGAGGPAHQVIVEATENPVFAH--STVVHPESR----------HHPPSNPRQQ 1134
                   Q    P     V+A  +P  +   S    P S+            PPS P   
Sbjct: 430  ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 489

Query: 1135 PHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGAR 1194
            P   S + PP  Q   P   PP +   PPP  P   A        S P++     P    
Sbjct: 490  PMSPSATPPP--QAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 547

Query: 1195 SHNPRNPASTAMGSSVPGYCQPITTVTAS--ASVTV-AVHPPPVPGPGRNPRG-----GL 1246
            +  P +P +T    + P    P+  V  S  AS T+ A   PP PGP  +  G      L
Sbjct: 548  ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLAL 607

Query: 1247 CPGYP 1251
             PG P
Sbjct: 608  APGPP 612



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 41/164 (25%), Positives = 56/164 (34%), Gaps = 34/164 (20%)

Query: 1045 PSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVI 1104
            P P PPPS       P  T SG D +    S+ +T     EELR Y++    G       
Sbjct: 609  PGPPPPPS-----RSPSSTLSGPDLAGHSSSATST----PEELRGYDSGPEGGA------ 653

Query: 1105 VEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLP------PGR--------QGQQ 1150
              A   P  A     HP +    P+ P          LP      PG         + + 
Sbjct: 654  --AASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEG 711

Query: 1151 PRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGAR 1194
            P    P  G   P   P     + +    +G S+R+   P+ AR
Sbjct: 712  PESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRS---PKQAR 752


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
          Length = 816

 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 67/245 (27%), Positives = 89/245 (36%), Gaps = 32/245 (13%)

Query: 1027 FGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEE 1086
            F P P +SP      L TP P+ PP++   A+PP      S  +    S   T S  +  
Sbjct: 341  FLPSPPLSP------LATPPPQAPPAL---ALPPLQA-PPSPPASPPLSPLATPSPQAPN 390

Query: 1087 LRHYEAQQGAGGPAHQVIVEATENPVFAH--STVVHPESR----------HHPPSNPRQQ 1134
                   Q    P     V+A  +P  +   S    P S+            PPS P   
Sbjct: 391  ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 450

Query: 1135 PHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGAR 1194
            P   S + PP  Q   P   PP +   PPP  P   A        S P++     P    
Sbjct: 451  PMSPSATPPP--QAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 508

Query: 1195 SHNPRNPASTAMGSSVPGYCQPITTVTAS--ASVTV-AVHPPPVPGPGRNPRG-----GL 1246
            +  P +P +T    + P    P+  V  S  AS T+ A   PP PGP  +  G      L
Sbjct: 509  ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLAL 568

Query: 1247 CPGYP 1251
             PG P
Sbjct: 569  APGPP 573



 Score = 35.8 bits (81), Expect = 0.27
 Identities = 53/218 (24%), Positives = 72/218 (33%), Gaps = 36/218 (16%)

Query: 1029 PYPEVSPANG---LNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSE 1085
            P  + +PA G    + L TPSP  PPS    + PP  +     S  +   SQ T S    
Sbjct: 279  PRKDAAPALGPLSSSPLATPSPSAPPSP---SAPP--SLQTLPSPPATPPSQATTS---- 329

Query: 1086 ELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPG 1145
                       G P  Q            HS +  P         P+  P L   +LPP 
Sbjct: 330  ----------LGSPTLQA----------THSFLPSPPLSPLATPPPQAPPAL---ALPPL 366

Query: 1146 RQGQQPRRDPPREGL-WPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPAST 1204
            +    P   PP   L  P P  P   A  +     S P +     P    +  P +P++T
Sbjct: 367  QAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT 426

Query: 1205 AMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1242
                + P    P   V  S   +  + P   P P   P
Sbjct: 427  PPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 464



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 41/164 (25%), Positives = 56/164 (34%), Gaps = 34/164 (20%)

Query: 1045 PSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVI 1104
            P P PPPS       P  T SG D +    S+ +T     EELR Y++    G       
Sbjct: 570  PGPPPPPS-----RSPSSTLSGPDLAGHSSSATST----PEELRGYDSGPEGGA------ 614

Query: 1105 VEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLP------PGR--------QGQQ 1150
              A   P  A     HP +    P+ P          LP      PG         + + 
Sbjct: 615  --AASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEG 672

Query: 1151 PRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGAR 1194
            P    P  G   P   P     + +    +G S+R+   P+ AR
Sbjct: 673  PESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRS---PKQAR 713


>gi|150417989 cyclin K isoform 1 [Homo sapiens]
          Length = 580

 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 55/204 (26%), Positives = 69/204 (33%), Gaps = 37/204 (18%)

Query: 1043 PTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQ 1102
            P P  +PPP   R   PP  ++    S+ S Y S        E  +  ++     GP++ 
Sbjct: 407  PAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMS-------GEGYQSLQSMMKTEGPSYG 459

Query: 1103 VIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWP 1162
             +  A   P  AH     P   H  P NP   P       PP      P   PP  G  P
Sbjct: 460  ALPPAYGPP--AHL----PYHPHVYPPNPPPPP-----VPPPPASFPPPAIPPPTPGYPP 508

Query: 1163 PPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTA 1222
            PP           T   + P    R  P  A   +P        G  +P    P   V  
Sbjct: 509  PP----------PTYNPNFPPPPPRLPPTHAVPPHP------PPGLGLPPASYPPPAVPP 552

Query: 1223 SASVTVAVHPPPVPGPGRNPRGGL 1246
                 V   PPP+P PG  P GGL
Sbjct: 553  GGQPPV---PPPIPPPGMPPVGGL 573



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 43/168 (25%), Positives = 53/168 (31%), Gaps = 28/168 (16%)

Query: 1105 VEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGR---------QGQQP---- 1151
            V+AT+ P        HP   H PP  P + P     S   G          +G Q     
Sbjct: 391  VDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSM 450

Query: 1152 -RRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSV 1210
             + + P  G  PP Y P      +    H  P N     P       P +    A+    
Sbjct: 451  MKTEGPSYGALPPAYGP---PAHLPYHPHVYPPN----PPPPPVPPPPASFPPPAIPPPT 503

Query: 1211 PGYCQPITTVTAS-------ASVTVAVHPPPVPGPGRNPRGGLCPGYP 1251
            PGY  P  T   +          T AV P P PG G  P     P  P
Sbjct: 504  PGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVP 551


>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
            preproprotein [Homo sapiens]
          Length = 331

 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 39/133 (29%), Positives = 50/133 (37%), Gaps = 31/133 (23%)

Query: 1130 NPRQQPHLDSGSLPPGRQGQQPRRDPPREG--LWPPPYRPRRDAFEISTEGHSGPSNRAR 1187
            +PR  P    G  PP + G QP+  PP  G    PPP    R       +G   P     
Sbjct: 89   SPRSPPGKPQG--PPPQGGNQPQGPPPPPGKPQGPPPQGGNR------PQGPPPPGKPQG 140

Query: 1188 WGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGP--------G 1239
              P+G +S +PR+P     G    G  QP               PPP PG         G
Sbjct: 141  PPPQGDKSRSPRSPPGKPQGPPPQGGNQP-------------QGPPPPPGKPQGPPPQGG 187

Query: 1240 RNPRGGLCPGYPE 1252
            + P+G   PG P+
Sbjct: 188  KKPQGPPPPGKPQ 200



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 35/126 (27%), Positives = 48/126 (38%), Gaps = 24/126 (19%)

Query: 1138 DSGSLPPGR-QGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGP--RGAR 1194
            +S SL  G  QG  P+     +G  PPP +P+    +   +    P      GP  +G +
Sbjct: 27   ESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDK 86

Query: 1195 SHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGP--------GRNPRGGL 1246
            S +PR+P     G    G  QP               PPP PG         G  P+G  
Sbjct: 87   SRSPRSPPGKPQGPPPQGGNQP-------------QGPPPPPGKPQGPPPQGGNRPQGPP 133

Query: 1247 CPGYPE 1252
             PG P+
Sbjct: 134  PPGKPQ 139


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 47/218 (21%), Positives = 81/218 (37%), Gaps = 44/218 (20%)

Query: 1029 PYPEV----SPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLS 1084
            P+P+V    SP     R P P+    P++   A+ PG   +   S  S  + QTT++ L 
Sbjct: 662  PHPKVPAPFSPPPSKPRSPNPAA---PALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQ 718

Query: 1085 EELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPP 1144
            E                  ++   ++P  +      P   +HPP  P ++P +   +   
Sbjct: 719  ES----------------PVISKDQSPPPS------PPPSYHPPPPPTKKPEVVVEAPSA 756

Query: 1145 GRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPAST 1204
                ++P +DP     WPPP  P  +  ++S      P            S  P  P+ +
Sbjct: 757  SETAEEPLQDPN----WPPPPPPAPEEQDLSMADFPPPEEAF----FSVASPEPAGPSGS 808

Query: 1205 AMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1242
                S P         ++S++  + + PP  P P   P
Sbjct: 809  PELVSSP-------AASSSSATALQIQPPGSPDPPPAP 839


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score = 42.7 bits (99), Expect = 0.002
 Identities = 39/142 (27%), Positives = 50/142 (35%), Gaps = 31/142 (21%)

Query: 1121 PESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREG--LWPPPYRPRRDAFEISTEG 1178
            P    + P  P   P    G  PP + G QP+  PP  G    PPP    +       +G
Sbjct: 40   PPQGGNKPQGPPSPPGKPQG--PPPQGGNQPQGPPPPPGKPQGPPPQGGNK------PQG 91

Query: 1179 HSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGP 1238
               P       P+G +S +PR+P     G    G  QP               PPP PG 
Sbjct: 92   PPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQP-------------QGPPPPPGK 138

Query: 1239 --------GRNPRGGLCPGYPE 1252
                    G  P+G   PG P+
Sbjct: 139  PQGPPPQGGNKPQGPPPPGKPQ 160



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 37/141 (26%), Positives = 48/141 (34%), Gaps = 39/141 (27%)

Query: 1123 SRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREG--LWPPPYRPRRDAFEISTEGHS 1180
            S   PP  P+          PP + G QP+  PP  G    PPP    +       +G  
Sbjct: 172  SSRSPPGKPQG---------PPPQGGNQPQGPPPPPGKPQGPPPQGGNK------PQGPP 216

Query: 1181 GPSNRARWGPRG-ARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGP- 1238
             P       P+G  +S + R+P     G    G  QP               PPP PG  
Sbjct: 217  PPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQP-------------QGPPPPPGKP 263

Query: 1239 -------GRNPRGGLCPGYPE 1252
                   G  P+G   PG P+
Sbjct: 264  QGPPPQGGNKPQGPPPPGKPQ 284



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 41/169 (24%), Positives = 57/169 (33%), Gaps = 50/169 (29%)

Query: 1121 PESRHHPPSNPRQQP----HLDSGSLPPGR-QGQQPR--------RDPPREGLWPPPY-- 1165
            P+    PP  P+  P    +   G  PPG+ QG  P+        R PP +   PPP   
Sbjct: 191  PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGG 250

Query: 1166 -----------RPRRDAFEISTEGHSGPSNRARWGP---RGARSHNPRNPASTAMGSSVP 1211
                       +P+    +   +    P      GP    G++S + R+P     G    
Sbjct: 251  NQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQ 310

Query: 1212 GYCQPITTVTASASVTVAVHPPPVPGP--------GRNPRGGLCPGYPE 1252
            G  QP               PPP PG         G  P+G   PG P+
Sbjct: 311  GGNQP-------------QGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ 346


>gi|224451135 splicing factor, arginine/serine-rich 15 isoform 3 [Homo
            sapiens]
          Length = 1125

 Score = 42.4 bits (98), Expect = 0.003
 Identities = 47/181 (25%), Positives = 64/181 (35%), Gaps = 41/181 (22%)

Query: 1031 PEVSPANGLNRLPTPSPEP----------PPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080
            P   P   L R P   P P          PP    FAMPP H   G       +     +
Sbjct: 840  PPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGM 899

Query: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140
             GL           G GGP  +                   + R  PP  P+QQP   + 
Sbjct: 900  PGLGGP------GPGPGGPEDR-------------------DGRQQPPQQPQQQPQPQAP 934

Query: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPR--GARSHNP 1198
              P  +Q QQP   PP +   P   +P++   +   + +SG  ++ R+G R  G R  N 
Sbjct: 935  QQPQQQQQQQP---PPSQQPPPTQQQPQQFRNDNRQQFNSG-RDQERFGRRSFGNRVEND 990

Query: 1199 R 1199
            R
Sbjct: 991  R 991


>gi|224451133 splicing factor, arginine/serine-rich 15 isoform 2 [Homo
            sapiens]
          Length = 1132

 Score = 42.4 bits (98), Expect = 0.003
 Identities = 47/181 (25%), Positives = 64/181 (35%), Gaps = 41/181 (22%)

Query: 1031 PEVSPANGLNRLPTPSPEP----------PPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080
            P   P   L R P   P P          PP    FAMPP H   G       +     +
Sbjct: 847  PPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGM 906

Query: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140
             GL           G GGP  +                   + R  PP  P+QQP   + 
Sbjct: 907  PGLGGP------GPGPGGPEDR-------------------DGRQQPPQQPQQQPQPQAP 941

Query: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPR--GARSHNP 1198
              P  +Q QQP   PP +   P   +P++   +   + +SG  ++ R+G R  G R  N 
Sbjct: 942  QQPQQQQQQQP---PPSQQPPPTQQQPQQFRNDNRQQFNSG-RDQERFGRRSFGNRVEND 997

Query: 1199 R 1199
            R
Sbjct: 998  R 998


>gi|40789229 splicing factor, arginine/serine-rich 15 isoform 1 [Homo
            sapiens]
          Length = 1147

 Score = 42.4 bits (98), Expect = 0.003
 Identities = 47/181 (25%), Positives = 64/181 (35%), Gaps = 41/181 (22%)

Query: 1031 PEVSPANGLNRLPTPSPEP----------PPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080
            P   P   L R P   P P          PP    FAMPP H   G       +     +
Sbjct: 862  PPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGM 921

Query: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140
             GL           G GGP  +                   + R  PP  P+QQP   + 
Sbjct: 922  PGLGGP------GPGPGGPEDR-------------------DGRQQPPQQPQQQPQPQAP 956

Query: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPR--GARSHNP 1198
              P  +Q QQP   PP +   P   +P++   +   + +SG  ++ R+G R  G R  N 
Sbjct: 957  QQPQQQQQQQP---PPSQQPPPTQQQPQQFRNDNRQQFNSG-RDQERFGRRSFGNRVEND 1012

Query: 1199 R 1199
            R
Sbjct: 1013 R 1013


>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
            tract binding protein associated) [Homo sapiens]
          Length = 707

 Score = 42.4 bits (98), Expect = 0.003
 Identities = 43/151 (28%), Positives = 58/151 (38%), Gaps = 28/151 (18%)

Query: 1127 PPSNPRQQPHLDSGSLPPGRQG---QQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPS 1183
            PP  P QQ        PP +Q    Q P    P +   PPP  P +D+ +       GP+
Sbjct: 61   PPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPP--PPQDSSKPVVAQGPGPA 118

Query: 1184 NRARWGPRGARSHNPRNPAST----------------AMGSSVPGYCQPITTVTASASVT 1227
                  P  + S  P  P ++                A+ S+ PG   P T  ++    T
Sbjct: 119  PGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPG-APPPTPPSSGVPTT 177

Query: 1228 V--AVHPPP----VPGPGRNPRGGLCPGYPE 1252
               A  PPP    VPGPG  P+ G  PG P+
Sbjct: 178  PPQAGGPPPPPAAVPGPGPGPKQGPGPGGPK 208



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 45/178 (25%), Positives = 55/178 (30%), Gaps = 23/178 (12%)

Query: 1029 PYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELR 1088
            P P   P       P P     P V +   P     S   +S S   +    SG      
Sbjct: 87   PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSG------ 140

Query: 1089 HYEAQQGAG-GPAHQVIVEATENPVFA-------HSTVVHPESRHHPPSNPRQQPHLDSG 1140
               A  G+G GP        T  P  A             P     PP  P   P    G
Sbjct: 141  ---APPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVP----G 193

Query: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNP 1198
              P  +QG  P    P+ G  P   +P       +  GH  P +R    PRG R H+P
Sbjct: 194  PGPGPKQGPGP--GGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHP 249



 Score = 32.0 bits (71), Expect = 3.9
 Identities = 55/226 (24%), Positives = 72/226 (31%), Gaps = 44/226 (19%)

Query: 1028 GPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEEL 1087
            GP P + P     +   P P+ PP       PP H          +          S+ +
Sbjct: 55   GPKPPIPPPPPHQQQQQPPPQQPPP----QQPPPHQPPPHPQPHQQQQPPPPPQDSSKPV 110

Query: 1088 RHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSN---PRQQPHLDSGSLPP 1144
                  QG  GPA  V    +  P  + +    P +   PP +   P   P     S PP
Sbjct: 111  ----VAQGP-GPAPGV---GSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPP 162

Query: 1145 GRQGQQPRRD-----PPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPR 1199
            G     P        PP+ G  PPP          +  G  GP  +   GP G +     
Sbjct: 163  GAPPPTPPSSGVPTTPPQAGGPPPP--------PAAVPG-PGPGPKQGPGPGGPK----- 208

Query: 1200 NPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGG 1245
                   G  +PG  +P      S   T   HP P    G  PRGG
Sbjct: 209  -------GGKMPGGPKPGGGPGLS---TPGGHPKPPHRGGGEPRGG 244


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,469,816
Number of Sequences: 37866
Number of extensions: 2815688
Number of successful extensions: 13092
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 330
Number of HSP's that attempted gapping in prelim test: 11851
Number of HSP's gapped (non-prelim): 1378
length of query: 1296
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1182
effective length of database: 13,930,794
effective search space: 16466198508
effective search space used: 16466198508
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press