BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|134254432 patched isoform L' [Homo sapiens] (1446 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|134254432 patched isoform L' [Homo sapiens] 2948 0.0 gi|134254446 patched isoform L [Homo sapiens] 2813 0.0 gi|134254466 patched isoform M [Homo sapiens] 2811 0.0 gi|134254450 patched isoform S [Homo sapiens] 2643 0.0 gi|134254435 patched isoform S [Homo sapiens] 2643 0.0 gi|134254468 patched isoform S [Homo sapiens] 2643 0.0 gi|134254452 patched isoform S [Homo sapiens] 2643 0.0 gi|52145305 patched 2 [Homo sapiens] 1278 0.0 gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens] 130 7e-30 gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapi... 126 1e-28 gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapi... 110 1e-23 gi|239754873 PREDICTED: similar to hCG2040393 [Homo sapiens] 92 4e-18 gi|239749412 PREDICTED: hypothetical protein XP_002347031 [Homo ... 92 4e-18 gi|239743547 PREDICTED: hypothetical protein XP_002342883 [Homo ... 92 4e-18 gi|194018513 patched domain containing 3 [Homo sapiens] 84 8e-16 gi|148271104 patched domain containing 1 [Homo sapiens] 82 3e-15 gi|148277106 hypothetical protein LOC442213 [Homo sapiens] 79 2e-14 gi|66932902 SREBF chaperone protein [Homo sapiens] 70 1e-11 gi|149274653 patched domain containing 2 [Homo sapiens] 53 2e-06 gi|25952134 dispatched A [Homo sapiens] 50 1e-05 gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 48 8e-05 gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 48 8e-05 gi|150417989 cyclin K isoform 1 [Homo sapiens] 45 5e-04 gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre... 44 9e-04 gi|112734870 hypothetical protein LOC57648 [Homo sapiens] 44 0.001 gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 43 0.003 gi|224451135 splicing factor, arginine/serine-rich 15 isoform 3 ... 42 0.003 gi|224451133 splicing factor, arginine/serine-rich 15 isoform 2 ... 42 0.003 gi|40789229 splicing factor, arginine/serine-rich 15 isoform 1 [... 42 0.003 gi|4826998 splicing factor proline/glutamine rich (polypyrimidin... 42 0.003 >gi|134254432 patched isoform L' [Homo sapiens] Length = 1446 Score = 2948 bits (7643), Expect = 0.0 Identities = 1446/1446 (100%), Positives = 1446/1446 (100%) Query: 1 MELLNRNRLVIVSPRCTPPKASGGPARRGFYTFRSFCKDGGGGEEEEENGGEEKDDRGDK 60 MELLNRNRLVIVSPRCTPPKASGGPARRGFYTFRSFCKDGGGGEEEEENGGEEKDDRGDK Sbjct: 1 MELLNRNRLVIVSPRCTPPKASGGPARRGFYTFRSFCKDGGGGEEEEENGGEEKDDRGDK 60 Query: 61 ETRSDKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANL 120 ETRSDKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANL Sbjct: 61 ETRSDKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANL 120 Query: 121 ETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDS 180 ETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDS Sbjct: 121 ETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDS 180 Query: 181 ALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKL 240 ALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKL Sbjct: 181 ALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKL 240 Query: 241 QSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPAD 300 QSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPAD Sbjct: 241 QSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPAD 300 Query: 301 PDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQ 360 PDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQ Sbjct: 301 PDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQ 360 Query: 361 TMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLS 420 TMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLS Sbjct: 361 TMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLS 420 Query: 421 FTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSV 480 FTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSV Sbjct: 421 FTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSV 480 Query: 481 AAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECL 540 AAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECL Sbjct: 481 AAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECL 540 Query: 541 KRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLY 600 KRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLY Sbjct: 541 KRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLY 600 Query: 601 RREDRRLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQST 660 RREDRRLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQST Sbjct: 601 RREDRRLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQST 660 Query: 661 VQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLH 720 VQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLH Sbjct: 661 VQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLH 720 Query: 721 CLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIV 780 CLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIV Sbjct: 721 CLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIV 780 Query: 781 PRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLP 840 PRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLP Sbjct: 781 PRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLP 840 Query: 841 KMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQ 900 KMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQ Sbjct: 841 KMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQ 900 Query: 901 LTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRL 960 LTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRL Sbjct: 901 LTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRL 960 Query: 961 RIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQY 1020 RIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQY Sbjct: 961 RIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQY 1020 Query: 1021 IGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAV 1080 IGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAV Sbjct: 1021 IGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAV 1080 Query: 1081 PVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLA 1140 PVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLA Sbjct: 1081 PVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLA 1140 Query: 1141 GSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPP 1200 GSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPP Sbjct: 1141 GSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPP 1200 Query: 1201 PSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATEN 1260 PSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATEN Sbjct: 1201 PSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATEN 1260 Query: 1261 PVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRD 1320 PVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRD Sbjct: 1261 PVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRD 1320 Query: 1321 AFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAV 1380 AFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAV Sbjct: 1321 AFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAV 1380 Query: 1381 HPPPVPGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERP 1440 HPPPVPGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERP Sbjct: 1381 HPPPVPGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERP 1440 Query: 1441 RGSSSN 1446 RGSSSN Sbjct: 1441 RGSSSN 1446 >gi|134254446 patched isoform L [Homo sapiens] Length = 1447 Score = 2813 bits (7291), Expect = 0.0 Identities = 1381/1381 (100%), Positives = 1381/1381 (100%) Query: 66 KGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVE 125 KGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVE Sbjct: 67 KGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVE 126 Query: 126 ELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQAS 185 ELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQAS Sbjct: 127 ELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQAS 186 Query: 186 RVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTA 245 RVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTA Sbjct: 187 RVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTA 246 Query: 246 YLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPA 305 YLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPA Sbjct: 247 YLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPA 306 Query: 306 TAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQL 365 TAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQL Sbjct: 307 TAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQL 366 Query: 366 MTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTT 425 MTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTT Sbjct: 367 MTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTT 426 Query: 426 LDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLG 485 LDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLG Sbjct: 427 LDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLG 486 Query: 486 LCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGA 545 LCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGA Sbjct: 487 LCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGA 546 Query: 546 SVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDR 605 SVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDR Sbjct: 547 SVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDR 606 Query: 606 RLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRT 665 RLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRT Sbjct: 607 RLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRT 666 Query: 666 EYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPP 725 EYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPP Sbjct: 667 EYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPP 726 Query: 726 CTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETR 785 CTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETR Sbjct: 727 CTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETR 786 Query: 786 EYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH 845 EYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH Sbjct: 787 EYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH 846 Query: 846 YFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQR 905 YFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQR Sbjct: 847 YFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQR 906 Query: 906 LVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAA 965 LVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAA Sbjct: 907 LVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAA 966 Query: 966 EPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRH 1025 EPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRH Sbjct: 967 EPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRH 1026 Query: 1026 WLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVIL 1085 WLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVIL Sbjct: 1027 WLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVIL 1086 Query: 1086 IASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFD 1145 IASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFD Sbjct: 1087 IASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFD 1146 Query: 1146 FIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVR 1205 FIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVR Sbjct: 1147 FIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVR 1206 Query: 1206 FAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAH 1265 FAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAH Sbjct: 1207 FAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAH 1266 Query: 1266 STVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEIS 1325 STVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEIS Sbjct: 1267 STVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEIS 1326 Query: 1326 TEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPV 1385 TEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPV Sbjct: 1327 TEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPV 1386 Query: 1386 PGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSS 1445 PGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSS Sbjct: 1387 PGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSS 1446 Query: 1446 N 1446 N Sbjct: 1447 N 1447 >gi|134254466 patched isoform M [Homo sapiens] Length = 1381 Score = 2811 bits (7286), Expect = 0.0 Identities = 1380/1380 (100%), Positives = 1380/1380 (100%) Query: 67 GKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEE 126 GKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEE Sbjct: 2 GKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEE 61 Query: 127 LWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASR 186 LWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASR Sbjct: 62 LWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASR 121 Query: 187 VHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAY 246 VHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAY Sbjct: 122 VHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAY 181 Query: 247 LLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPAT 306 LLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPAT Sbjct: 182 LLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPAT 241 Query: 307 APNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLM 366 APNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLM Sbjct: 242 APNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLM 301 Query: 367 TPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTL 426 TPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTL Sbjct: 302 TPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTL 361 Query: 427 DDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGL 486 DDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGL Sbjct: 362 DDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGL 421 Query: 487 CSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGAS 546 CSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGAS Sbjct: 422 CSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGAS 481 Query: 547 VALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRR 606 VALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRR Sbjct: 482 VALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRR 541 Query: 607 LDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTE 666 LDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTE Sbjct: 542 LDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTE 601 Query: 667 YDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPC 726 YDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPC Sbjct: 602 YDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPC 661 Query: 727 TKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETRE 786 TKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETRE Sbjct: 662 TKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETRE 721 Query: 787 YDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHY 846 YDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHY Sbjct: 722 YDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHY 781 Query: 847 FRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRL 906 FRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRL Sbjct: 782 FRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRL 841 Query: 907 VDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAE 966 VDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAE Sbjct: 842 VDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAE 901 Query: 967 PIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHW 1026 PIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHW Sbjct: 902 PIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHW 961 Query: 1027 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 1086 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI Sbjct: 962 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 1021 Query: 1087 ASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDF 1146 ASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDF Sbjct: 1022 ASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDF 1081 Query: 1147 IVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRF 1206 IVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRF Sbjct: 1082 IVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRF 1141 Query: 1207 AMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHS 1266 AMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHS Sbjct: 1142 AMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHS 1201 Query: 1267 TVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEIST 1326 TVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEIST Sbjct: 1202 TVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEIST 1261 Query: 1327 EGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVP 1386 EGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVP Sbjct: 1262 EGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVP 1321 Query: 1387 GPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1446 GPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN Sbjct: 1322 GPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1381 >gi|134254450 patched isoform S [Homo sapiens] Length = 1296 Score = 2644 bits (6852), Expect = 0.0 Identities = 1296/1296 (100%), Positives = 1296/1296 (100%) Query: 151 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 210 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT Sbjct: 1 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60 Query: 211 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 270 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI Sbjct: 61 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120 Query: 271 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 330 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS Sbjct: 121 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180 Query: 331 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 390 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK Sbjct: 181 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240 Query: 391 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 450 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA Sbjct: 241 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300 Query: 451 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 510 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG Sbjct: 301 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360 Query: 511 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 570 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR Sbjct: 361 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420 Query: 571 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 630 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT Sbjct: 421 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480 Query: 631 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 690 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT Sbjct: 481 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540 Query: 691 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 750 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV Sbjct: 541 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600 Query: 751 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 810 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD Sbjct: 601 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660 Query: 811 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 870 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN Sbjct: 661 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720 Query: 871 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 930 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP Sbjct: 721 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780 Query: 931 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 990 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI Sbjct: 781 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840 Query: 991 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 1050 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW Sbjct: 841 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900 Query: 1051 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 1110 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK Sbjct: 901 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960 Query: 1111 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1170 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL Sbjct: 961 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020 Query: 1171 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1230 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080 Query: 1231 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1290 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG Sbjct: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140 Query: 1291 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1350 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN Sbjct: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200 Query: 1351 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1410 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED Sbjct: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260 Query: 1411 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1446 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN Sbjct: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296 >gi|134254435 patched isoform S [Homo sapiens] Length = 1296 Score = 2644 bits (6852), Expect = 0.0 Identities = 1296/1296 (100%), Positives = 1296/1296 (100%) Query: 151 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 210 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT Sbjct: 1 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60 Query: 211 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 270 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI Sbjct: 61 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120 Query: 271 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 330 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS Sbjct: 121 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180 Query: 331 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 390 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK Sbjct: 181 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240 Query: 391 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 450 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA Sbjct: 241 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300 Query: 451 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 510 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG Sbjct: 301 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360 Query: 511 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 570 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR Sbjct: 361 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420 Query: 571 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 630 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT Sbjct: 421 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480 Query: 631 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 690 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT Sbjct: 481 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540 Query: 691 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 750 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV Sbjct: 541 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600 Query: 751 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 810 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD Sbjct: 601 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660 Query: 811 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 870 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN Sbjct: 661 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720 Query: 871 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 930 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP Sbjct: 721 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780 Query: 931 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 990 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI Sbjct: 781 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840 Query: 991 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 1050 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW Sbjct: 841 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900 Query: 1051 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 1110 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK Sbjct: 901 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960 Query: 1111 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1170 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL Sbjct: 961 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020 Query: 1171 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1230 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080 Query: 1231 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1290 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG Sbjct: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140 Query: 1291 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1350 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN Sbjct: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200 Query: 1351 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1410 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED Sbjct: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260 Query: 1411 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1446 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN Sbjct: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296 >gi|134254468 patched isoform S [Homo sapiens] Length = 1296 Score = 2644 bits (6852), Expect = 0.0 Identities = 1296/1296 (100%), Positives = 1296/1296 (100%) Query: 151 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 210 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT Sbjct: 1 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60 Query: 211 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 270 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI Sbjct: 61 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120 Query: 271 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 330 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS Sbjct: 121 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180 Query: 331 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 390 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK Sbjct: 181 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240 Query: 391 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 450 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA Sbjct: 241 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300 Query: 451 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 510 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG Sbjct: 301 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360 Query: 511 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 570 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR Sbjct: 361 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420 Query: 571 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 630 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT Sbjct: 421 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480 Query: 631 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 690 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT Sbjct: 481 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540 Query: 691 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 750 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV Sbjct: 541 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600 Query: 751 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 810 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD Sbjct: 601 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660 Query: 811 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 870 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN Sbjct: 661 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720 Query: 871 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 930 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP Sbjct: 721 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780 Query: 931 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 990 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI Sbjct: 781 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840 Query: 991 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 1050 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW Sbjct: 841 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900 Query: 1051 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 1110 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK Sbjct: 901 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960 Query: 1111 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1170 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL Sbjct: 961 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020 Query: 1171 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1230 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080 Query: 1231 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1290 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG Sbjct: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140 Query: 1291 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1350 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN Sbjct: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200 Query: 1351 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1410 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED Sbjct: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260 Query: 1411 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1446 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN Sbjct: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296 >gi|134254452 patched isoform S [Homo sapiens] Length = 1296 Score = 2644 bits (6852), Expect = 0.0 Identities = 1296/1296 (100%), Positives = 1296/1296 (100%) Query: 151 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 210 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT Sbjct: 1 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELIT 60 Query: 211 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 270 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI Sbjct: 61 ETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI 120 Query: 271 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 330 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS Sbjct: 121 NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS 180 Query: 331 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 390 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK Sbjct: 181 RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDK 240 Query: 391 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 450 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA Sbjct: 241 AAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLA 300 Query: 451 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 510 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG Sbjct: 301 YACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG 360 Query: 511 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 570 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR Sbjct: 361 VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR 420 Query: 571 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 630 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT Sbjct: 421 AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480 Query: 631 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 690 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT Sbjct: 481 DTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT 540 Query: 691 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 750 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV Sbjct: 541 VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKV 600 Query: 751 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 810 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD Sbjct: 601 VVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKAD 660 Query: 811 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 870 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN Sbjct: 661 YPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN 720 Query: 871 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 930 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP Sbjct: 721 NYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDP 780 Query: 931 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 990 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI Sbjct: 781 VAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAI 840 Query: 991 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 1050 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW Sbjct: 841 EKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPW 900 Query: 1051 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 1110 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK Sbjct: 901 TAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDK 960 Query: 1111 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1170 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL Sbjct: 961 NRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1020 Query: 1171 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1230 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV Sbjct: 1021 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1080 Query: 1231 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1290 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG Sbjct: 1081 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1140 Query: 1291 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1350 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN Sbjct: 1141 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRN 1200 Query: 1351 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1410 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED Sbjct: 1201 PASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFED 1260 Query: 1411 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1446 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN Sbjct: 1261 PHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1296 >gi|52145305 patched 2 [Homo sapiens] Length = 1203 Score = 1278 bits (3306), Expect = 0.0 Identities = 634/1114 (56%), Positives = 828/1114 (74%), Gaps = 27/1114 (2%) Query: 73 KAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVG 132 KAPLWLRA FQ LLF LGC IQ++CGK L +GLL FGA A+GL+ A +ETN+E+LWVEVG Sbjct: 31 KAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVG 90 Query: 133 GRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMY 192 RVS+EL+YT++K+GEEA + Q++IQT ++EG N+LT EAL HL +AL AS+V V +Y Sbjct: 91 SRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLY 150 Query: 193 NRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPP 252 + W L +CYKSG + E G ++++IE L+PC+I+TPLDCFWEGAKLQ G+AYL G+P Sbjct: 151 GKSWDLNKICYKSGVPLIENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPD 210 Query: 253 LRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNS 312 ++WTN DP + LEEL ++ + E+L+KA+VG Y+ RPCL+P D CP +APN +S Sbjct: 211 IQWTNLDPEQLLEELGPFA-SLEGFRELLDKAQVGQAYVGRPCLHPDDLHCPPSAPNHHS 269 Query: 313 TKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMY 372 + ++A L+GGCHG S K+MHWQEEL++GG ++ G+L+ A ALQ+ F LM+P+Q+Y Sbjct: 270 RQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQLY 329 Query: 373 EHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKS 432 EHF+G I W+E++A+ +L+AWQR +V++ +++ +N++Q++ +F++TTLDDIL + Sbjct: 330 EHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHA 389 Query: 433 FSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGI 492 FS+VS RV GYLLMLAYAC+TMLRWDC++SQG+VGLAGVLLVAL+VA+GLGLC+L+GI Sbjct: 390 FSEVSAARVVGGYLLMLAYACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGI 449 Query: 493 SFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSI 552 +FNAATTQVLPFLALG+GVDDVFLLAHAF+E P ++R GECL+RTG SV LTSI Sbjct: 450 TFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPG--TPLQERMGECLQRTGTSVVLTSI 507 Query: 553 SNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 612 +N+ AF MAAL+PIPALRAFSLQAA+VV F V+L+FPAILS+DL RR +RLD+ CC Sbjct: 508 NNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCC 567 Query: 613 FTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTH 672 F+SPC ++VIQ+ PQ D P +H + +TVQ T + + Sbjct: 568 FSSPCSAQVIQILPQELGD-------GTVPVGIAH---------LTATVQAFTHCEASSQ 611 Query: 673 VYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDS--SLHCLEPPCTKWT 730 T P++ + P D L + STRDLL Q ++ C PC +W Sbjct: 612 HVVTILPPQAHLVPPP----SDPLGSELFSPGGSTRDLLGQEEETRQKAACKSLPCARWN 667 Query: 731 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 790 L+ FA +AP LL+ AK +V+ LF LLG+SLYG T V+DGL LTD+VPR T+E+ F+ Sbjct: 668 LAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFL 727 Query: 791 AAQFKYFSFYNMYIVTQKA-DYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRD 849 +AQ +YFS Y + +VTQ DY + Q L+DLH+ FS++K V+ Q P+ WLHY+R+ Sbjct: 728 SAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRN 787 Query: 850 WLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDA 909 WLQG+Q AFD DW +G+I ++Y+NGS+DG LAYKLL+QTG +P+D SQLT ++LVD Sbjct: 788 WLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDR 847 Query: 910 DGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIE 969 +G+I P FY+ LT WVS+DP+ AASQAN P PEW+HDK D E LRIP A+P+E Sbjct: 848 EGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGE-NLRIPPAQPLE 906 Query: 970 YAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLL 1029 +AQFPF L GL+ T+DFVEAIE R C+ G+ +YP+G PFLFWEQY+GLR LL Sbjct: 907 FAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLL 966 Query: 1030 FISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASV 1089 + ++L CTFLVCA+ LLNPWTAG+IV+VLA+MTVELFG+MG +GIKLSA+PVVIL+ASV Sbjct: 967 AVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASV 1026 Query: 1090 GIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVR 1149 GIGVEFTVHVAL FLT G +N RA ALEH FAPV DGA+STLLG+LMLAGS FDFIVR Sbjct: 1027 GIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVR 1086 Query: 1150 YFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEV 1183 YFFA L +LT+LG+L+GLVLLPVLLS GP PEV Sbjct: 1087 YFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEV 1120 Score = 31.2 bits (69), Expect = 7.6 Identities = 16/35 (45%), Positives = 22/35 (62%), Gaps = 5/35 (14%) Query: 1358 SSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1392 SS+P +TT S+TVA+HPPP+PG +P Sbjct: 1147 SSLPQSFARVTT-----SMTVAIHPPPLPGAYIHP 1176 >gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens] Length = 1278 Score = 130 bits (328), Expect = 7e-30 Identities = 126/476 (26%), Positives = 214/476 (44%), Gaps = 66/476 (13%) Query: 731 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 790 L F + Y+P LLK + +VI +F+G+L S+ +V GLD + +P ++ D+ Sbjct: 817 LFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYF 876 Query: 791 AAQFKYF-SFYNMYIVTQKA-DYP--------------NIQHLLYDLHRSFSNVKYVMLE 834 + +Y + +Y V ++ DY N L+ + + Y + Sbjct: 877 KSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIG 936 Query: 835 ENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGS--DDGVLAYKLLVQTGSR 892 P W+ + DW++ D T + + N S D + + L G Sbjct: 937 F---APSSWIDDYFDWVKPQSSCCRVDNIT-----DQFCNASVVDPACVRCRPLTPEG-- 986 Query: 893 DKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKA 952 KQR D F +L ++S++P P + H A Sbjct: 987 ----------KQRPQGGD-------FMRFLPMFLSDNP----------NPKCGKGGH--A 1017 Query: 953 DYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSS---- 1007 Y + + + F Y L+ ++DF++A++K R I SN T ++G++ Sbjct: 1018 AYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYR 1077 Query: 1008 -YPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFL-LNPWTAGIIVMVLALMTVE 1065 +P ++F+EQY+ + + + V L FLV V L W+A I+ +A++ V Sbjct: 1078 VFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVN 1137 Query: 1066 LFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAI-GDKNRRAVLALEHMFAP 1124 +FG+M L GI L+AV +V L+ S GI VEF H+ AF ++ G + RA AL HM + Sbjct: 1138 MFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSS 1197 Query: 1125 VLDGAVSTLL-GVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1179 V G T G+++LA ++ ++F + + +LG +GL+ LPVLLS+ GP Sbjct: 1198 VFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGP 1253 Score = 130 bits (326), Expect = 1e-29 Identities = 77/233 (33%), Positives = 123/233 (52%), Gaps = 9/233 (3%) Query: 386 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASG 444 +N+ + +AW++ ++ V N T +SFT +++D L SD V V Sbjct: 571 YNDTEKLQRAQAWEKEFINFVKNYKNPNLT---ISFTAERSIEDELNRESDSDVFTVVIS 627 Query: 445 YLLMLAYACLTM-----LRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATT 499 Y +M Y L + R S+ ++G+AG+L+V SVA LG+ S IG+ Sbjct: 628 YAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVI 687 Query: 500 QVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFF 559 +V+PFL L VGVD++F+L A+ + + + + G L S+ L+S S AFF Sbjct: 688 EVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFF 747 Query: 560 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 612 + AL +PA+ FSL A + V +F + + F ++L +D+ R+E RLDIFCC Sbjct: 748 LGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC 800 >gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapiens] Length = 1332 Score = 126 bits (317), Expect = 1e-28 Identities = 140/544 (25%), Positives = 236/544 (43%), Gaps = 96/544 (17%) Query: 731 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 790 L F +K YAPFLL + VV+ LFL L GVSLY + GLD +P+++ D+ Sbjct: 828 LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYF 887 Query: 791 AAQFKYFSF-----------YN------MYIVTQKADYPNI---QHLLYDLHRSFSNVKY 830 +YF YN M + A N Q + Y F Y Sbjct: 888 LFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATE--FPEQSY 945 Query: 831 VMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTG 890 + + + W+ F DWL P++ +L + Sbjct: 946 LAIPASS-----WVDDFIDWLT----------------PSS----------CCRLYISGP 974 Query: 891 SRDK--PIDISQLT--KQRLVDADGIINPSA--FYIYLTAWVSNDPVAYAASQANIRPHR 944 ++DK P ++ L K + G + PS F+ YL W ND + + + Sbjct: 975 NKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLP-WFLNDRPNIKCPKGGLAAY- 1032 Query: 945 PEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTS-- 1002 T + + + + ++F Y L+++ D+ EA+ R + +N T+ Sbjct: 1033 ------------STSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL 1080 Query: 1003 -------LGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGII 1055 +P +F+EQY+ + L +S+ L TF V + L +G++ Sbjct: 1081 RKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLL 1140 Query: 1056 -VMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKN--- 1111 ++ + ++ V+ G M L GI +AV ++ L+++VG+ VEF H+ +F AI K Sbjct: 1141 NLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSF--AISTKPTWL 1198 Query: 1112 RRAVLALEHMFAPVLDG-AVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLL 1170 RA A M + V G A++ L G+L+L ++ I +FF + ++T+LG+L+GLV L Sbjct: 1199 ERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFL 1258 Query: 1171 PVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTH--SGSDSSDSEYSSQT 1228 PV+LS+ G P+V+PA L + E + V A P H S +D+ +S + Sbjct: 1259 PVILSYVG--PDVNPALALEQ---KRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEG 1313 Query: 1229 TVSG 1232 ++ G Sbjct: 1314 SIKG 1317 Score = 110 bits (274), Expect = 1e-23 Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 6/230 (2%) Query: 389 DKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASGYLL 447 D A + W+ ++E + + + ++F +L+D + + + A+ Y++ Sbjct: 583 DPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIV 642 Query: 448 MLAYACLTMLRWDCSK-----SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVL 502 + Y L + + S+ +GL GV +V +V A +G S +GI + QV+ Sbjct: 643 IFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVV 702 Query: 503 PFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA 562 PFL L VG D++F+ + + P E G L R S+ L S+S FF+ A Sbjct: 703 PFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGA 762 Query: 563 LIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 612 L P+PA+R F+L + + V+ +F + + F A+LS+D R+E RLD+ CC Sbjct: 763 LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812 >gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapiens] Length = 1359 Score = 110 bits (274), Expect = 1e-23 Identities = 66/230 (28%), Positives = 115/230 (50%), Gaps = 6/230 (2%) Query: 389 DKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASGYLL 447 D A + W+ ++E + + + ++F +L+D + + + A+ Y++ Sbjct: 583 DPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIV 642 Query: 448 MLAYACLTMLRWDCSK-----SQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVL 502 + Y L + + S+ +GL GV +V +V A +G S +GI + QV+ Sbjct: 643 IFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVV 702 Query: 503 PFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA 562 PFL L VG D++F+ + + P E G L R S+ L S+S FF+ A Sbjct: 703 PFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGA 762 Query: 563 LIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 612 L P+PA+R F+L + + V+ +F + + F A+LS+D R+E RLD+ CC Sbjct: 763 LTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCC 812 Score = 103 bits (256), Expect = 2e-21 Identities = 82/278 (29%), Positives = 144/278 (51%), Gaps = 23/278 (8%) Query: 971 AQFPFYLNGLRDTSDFVEAIEKVRTICSNYTS---------LGLSSYPNGYPFLFWEQYI 1021 ++F Y L+++ D+ EA+ R + +N T+ +P +F+EQY+ Sbjct: 1074 SRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYL 1133 Query: 1022 GLRHWLLLFISVVLACTFLVCAVFLLNPWTAGII-VMVLALMTVELFGMMGLIGIKLSAV 1080 + L +S+ L TF V + L +G++ ++ + ++ V+ G M L GI +AV Sbjct: 1134 TILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAV 1193 Query: 1081 PVVILIASVGIGVEFTVHVALAFLTAIGDKN---RRAVLALEHMFAPVLDG-AVSTLLGV 1136 ++ L+++VG+ VEF H+ +F AI K RA A M + V G A++ L G+ Sbjct: 1194 SLINLVSAVGMSVEFVSHITRSF--AISTKPTWLERAKEATISMGSAVFAGVAMTNLPGI 1251 Query: 1137 LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPS 1196 L+L ++ I +FF + ++T+LG+L+GLV LPV+LS+ G P+V+PA L + Sbjct: 1252 LVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVG--PDVNPALALEQ---KR 1306 Query: 1197 PEPPPSVVRFAMPPGHTH--SGSDSSDSEYSSQTTVSG 1232 E + V A P H S +D+ +S + ++ G Sbjct: 1307 AEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEGSIKG 1344 Score = 48.9 bits (115), Expect = 4e-05 Identities = 27/67 (40%), Positives = 37/67 (55%) Query: 731 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 790 L F +K YAPFLL + VV+ LFL L GVSLY + GLD +P+++ D+ Sbjct: 828 LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYF 887 Query: 791 AAQFKYF 797 +YF Sbjct: 888 LFLNRYF 894 >gi|239754873 PREDICTED: similar to hCG2040393 [Homo sapiens] Length = 333 Score = 92.0 bits (227), Expect = 4e-18 Identities = 93/295 (31%), Positives = 113/295 (38%), Gaps = 52/295 (17%) Query: 1185 PANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQ 1244 P + R P P P S R PG GS + + + RH + Sbjct: 58 PGHTAPRTQQPKPSGPSSHPREPPLPGAVTGGS----LHFQEPPPLGAATAGSRHRQKPP 113 Query: 1245 GAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPS---NPRQQPHL-DSGSLPPGRQGQQ 1300 G E P +T R PPS HL SGS R Sbjct: 114 SPGSR------HRWEPPPPGAATATGSRHRREPPSPGATTAGSCHLRSSGSTGTRRAPSH 167 Query: 1301 PR-------RDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWG---PRGARSHNP-- 1348 P R+ PRE PP P+ A EG S WG P+G R Sbjct: 168 PAALQVPYTREGPREPT--PPAGPQGFAGSFCAEG-SRRGAEVGWGKLEPQGTRRTGSLG 224 Query: 1349 --RNPASTAMGSSVPG------------YCQPITTVTASASVTVAVHPPPVPGPGRNPRG 1394 +P S +G + G +C I + P PGP ++P+ Sbjct: 225 VDSSPLSETLGPAQCGSGRRRACSVLHHHCDGIRFRDCHCA------PSACPGPTQDPQA 278 Query: 1395 GLCPG---YPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1446 GLC G YP TDHGLF PH+ F V+ ER + KVEV ELQDVECEE PRGSSSN Sbjct: 279 GLCTGQEGYPGTDHGLFMGPHLLFQVQGERTNLKVEVTELQDVECEEWPRGSSSN 333 >gi|239749412 PREDICTED: hypothetical protein XP_002347031 [Homo sapiens] Length = 333 Score = 92.0 bits (227), Expect = 4e-18 Identities = 93/295 (31%), Positives = 113/295 (38%), Gaps = 52/295 (17%) Query: 1185 PANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQ 1244 P + R P P P S R PG GS + + + RH + Sbjct: 58 PGHTAPRTQQPKPSGPSSHPREPPLPGAVTGGS----LHFQEPPPLGAATAGSRHRQKPP 113 Query: 1245 GAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPS---NPRQQPHL-DSGSLPPGRQGQQ 1300 G E P +T R PPS HL SGS R Sbjct: 114 SPGSR------HRWEPPPPGAATATGSRHRREPPSPGATTAGSCHLRSSGSTGTRRAPSH 167 Query: 1301 PR-------RDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWG---PRGARSHNP-- 1348 P R+ PRE PP P+ A EG S WG P+G R Sbjct: 168 PAALQVPYTREGPREPT--PPAGPQGFAGSFCAEG-SRRGAEVGWGKLEPQGTRRTGSLG 224 Query: 1349 --RNPASTAMGSSVPG------------YCQPITTVTASASVTVAVHPPPVPGPGRNPRG 1394 +P S +G + G +C I + P PGP ++P+ Sbjct: 225 VDSSPLSETLGPAQCGSGRRRACSVLHHHCDGIRFRDCHCA------PSACPGPTQDPQA 278 Query: 1395 GLCPG---YPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1446 GLC G YP TDHGLF PH+ F V+ ER + KVEV ELQDVECEE PRGSSSN Sbjct: 279 GLCTGQEGYPGTDHGLFMGPHLLFQVQGERTNLKVEVTELQDVECEEWPRGSSSN 333 >gi|239743547 PREDICTED: hypothetical protein XP_002342883 [Homo sapiens] Length = 333 Score = 92.0 bits (227), Expect = 4e-18 Identities = 93/295 (31%), Positives = 113/295 (38%), Gaps = 52/295 (17%) Query: 1185 PANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQ 1244 P + R P P P S R PG GS + + + RH + Sbjct: 58 PGHTAPRTQQPKPSGPSSHPREPPLPGAVTGGS----LHFQEPPPLGAATAGSRHRQKPP 113 Query: 1245 GAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPS---NPRQQPHL-DSGSLPPGRQGQQ 1300 G E P +T R PPS HL SGS R Sbjct: 114 SPGSR------HRWEPPPPGAATATGSRHRREPPSPGATTAGSCHLRSSGSTGTRRAPSH 167 Query: 1301 PR-------RDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWG---PRGARSHNP-- 1348 P R+ PRE PP P+ A EG S WG P+G R Sbjct: 168 PAALQVPYTREGPREPT--PPAGPQGFAGSFCAEG-SRRGAEVGWGKLEPQGTRRTGSLG 224 Query: 1349 --RNPASTAMGSSVPG------------YCQPITTVTASASVTVAVHPPPVPGPGRNPRG 1394 +P S +G + G +C I + P PGP ++P+ Sbjct: 225 VDSSPLSETLGPAQCGSGRRRACSVLHHHCDGIRFRDCHCA------PSACPGPTQDPQA 278 Query: 1395 GLCPG---YPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN 1446 GLC G YP TDHGLF PH+ F V+ ER + KVEV ELQDVECEE PRGSSSN Sbjct: 279 GLCTGQEGYPGTDHGLFMGPHLLFQVQGERTNLKVEVTELQDVECEEWPRGSSSN 333 >gi|194018513 patched domain containing 3 [Homo sapiens] Length = 767 Score = 84.3 bits (207), Expect = 8e-16 Identities = 62/246 (25%), Positives = 120/246 (48%), Gaps = 20/246 (8%) Query: 353 LVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQ 412 L+ A A++ ++ L T Y+ + ++++H+ D+ I +EVVH + Sbjct: 316 LLRAKAMRLLYYLKTEDPEYD-VQSKQWLTHLL---DQFTNIKNILALKKIEVVHFT--- 368 Query: 413 NSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAG 472 S + L F T S + + V +A Y+L++ +A + R+DC +++ V G Sbjct: 369 -SLSRQLEFEAT-------SVTVIPVFHLA--YILIILFAVTSCFRFDCIRNKMCVAAFG 418 Query: 473 VLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPF 532 V+ L+V +G GL IG+ F PFL LGVGVDD+F++ A+ +T N Sbjct: 419 VISAFLAVVSGFGLLLHIGVPFVIIVAN-SPFLILGVGVDDMFIMISAWHKT--NLADDI 475 Query: 533 EDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFP 592 +R + S+ +T+I+N+ A + + +++ F + + ++F + + F Sbjct: 476 RERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFG 535 Query: 593 AILSMD 598 A +++D Sbjct: 536 AFMALD 541 Score = 60.5 bits (145), Expect = 1e-08 Identities = 37/128 (28%), Positives = 68/128 (53%), Gaps = 9/128 (7%) Query: 731 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 790 +S F ++ PFL + ++K V+F+++ + S+YG V++GLDL ++ ++ + Sbjct: 584 ISLFFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYF 643 Query: 791 AAQFKYFSFYN---MYIVTQKADY--PNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH 845 + YFS Y M IVT+K DY +++ L + + F YV +K L + WL Sbjct: 644 NVEENYFSDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYV----DKNLTEFWLD 699 Query: 846 YFRDWLQG 853 + +L+G Sbjct: 700 AYVQYLKG 707 >gi|148271104 patched domain containing 1 [Homo sapiens] Length = 888 Score = 82.4 bits (202), Expect = 3e-15 Identities = 65/272 (23%), Positives = 126/272 (46%), Gaps = 24/272 (8%) Query: 342 VGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRT 401 +GG +S ++ SA A+Q + Y+ IN D A E W+ + Sbjct: 192 LGGVTVHSKDRVKSAEAIQLTY----------------YLQSINSLNDMVA---ERWESS 232 Query: 402 YVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDC 461 + + V NS K+ +T+++L + + S VS + + +L++ A L DC Sbjct: 233 FCDTVRLFQKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDC 292 Query: 462 SKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF 521 +S+ +GL G++ ++L+ G+ +L G +N +T +PF+ LG G+ F + ++ Sbjct: 293 VRSKPWLGLLGLVTISLATLTAAGIINLTGGKYN-STFLGVPFVMLGHGLYGTFEMLSSW 351 Query: 522 SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFSLQAAVV 579 +T +++ + ++RT + S +LT+ + F + A I A R F + + Sbjct: 352 RKTREDQHV--KERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIA 409 Query: 580 VVFNFAMVLLIFPAILSMDLYRREDRRLDIFC 611 + FN+ VL + + L Y + + IFC Sbjct: 410 IFFNYLYVLSFYGSSLVFTGYIENNYQHSIFC 441 Score = 44.7 bits (104), Expect = 7e-04 Identities = 23/74 (31%), Positives = 40/74 (54%) Query: 731 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 790 L F +++Y ++ K V+ +L + +L G +V +G DL++IV T+ ++ Sbjct: 483 LVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYT 542 Query: 791 AAQFKYFSFYNMYI 804 AQ KYFS Y+ I Sbjct: 543 TAQQKYFSNYSPVI 556 Score = 31.6 bits (70), Expect = 5.8 Identities = 36/155 (23%), Positives = 66/155 (42%), Gaps = 16/155 (10%) Query: 1028 LLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVE--LFGMMGLIGIKLSAVPVVIL 1085 LLF S L A L+N W + L +++VE + G M L ++L + V+ L Sbjct: 710 LLFFSAFLV------ADSLINVW------ITLTVVSVEFGVIGFMTLWKVELDCISVLCL 757 Query: 1086 IASVGIGVEFTVHVALAFLTAIGDKNRRAVL-ALEHMFAPVLDGAVSTLLGVLMLAGSEF 1144 I + ++ + F+ + V ALE +L + ++G++ LA Sbjct: 758 IYGINYTIDNCAPMLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLIPLAAVPS 817 Query: 1145 DFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1179 + F L ++ + + +LPV+L+F P Sbjct: 818 NLTCT-LFRCLFLIAFVTFFHCFAILPVILTFLPP 851 >gi|148277106 hypothetical protein LOC442213 [Homo sapiens] Length = 829 Score = 79.3 bits (194), Expect = 2e-14 Identities = 62/260 (23%), Positives = 112/260 (43%), Gaps = 7/260 (2%) Query: 396 EAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLT 455 E W+ + +++ + ++ ++ S + +L S ++ +V +L+L A L+ Sbjct: 175 EKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLS 234 Query: 456 MLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVF 515 DC +S+ +GL GVL V +S+ G+ + +N +T +PF A+G G VF Sbjct: 235 SSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYN-STLLGIPFFAMGHGTKGVF 293 Query: 516 LLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAA--LIPIPALRAFS 573 L + T +N +PF+DR + + +TS F M A I A++ F Sbjct: 294 ELLSGWRRTKEN--LPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFC 351 Query: 574 LQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF--TSPCVSRVIQVEPQAYTD 631 V ++ N+ + F + L ++R IFCC ++ + R +D Sbjct: 352 QNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSD 411 Query: 632 THDNTRYSPPPPYSSHSFAH 651 H T + PY H H Sbjct: 412 GHQQTSHHETNPYQHHFIQH 431 Score = 43.5 bits (101), Expect = 0.001 Identities = 43/183 (23%), Positives = 84/183 (45%), Gaps = 9/183 (4%) Query: 731 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 790 + F +HY ++ K V+ L+L S G ++ DG ++ +++ ++ + Sbjct: 429 IQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYA 488 Query: 791 AAQFKYFSFYNMYI---VTQKADYPN--IQHLLYDLHRSFSNVKYV-MLEENKQLPKMWL 844 Q KYFS Y+ I V + +Y N +Q L L F+ V +V + ++ + Sbjct: 489 MVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSA 548 Query: 845 HYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKL-LVQTGSRDKPIDISQL 901 + D++ LQ +F E + K G + ++A +L LV SRDK +I+++ Sbjct: 549 NNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEV 608 Query: 902 TKQ 904 ++ Sbjct: 609 LEK 611 Score = 41.6 bits (96), Expect = 0.006 Identities = 39/174 (22%), Positives = 78/174 (44%), Gaps = 12/174 (6%) Query: 1015 LFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTA----GIIVMVLALMTVEL--FG 1068 +F ++ + H+ L VL F V V +L + G ++L++ ++EL G Sbjct: 625 VFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLG 684 Query: 1069 MMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLA-LEHMFAPVLD 1127 +M L + + + ++ LI ++ ++ + F+ A + + + L+ +L Sbjct: 685 LMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQ 744 Query: 1128 GAVSTLLGV--LMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1179 S L+G+ L+ S F + F L + +L+ V+LPV L+FF P Sbjct: 745 NVTSFLIGLVPLLFVPSNLTFTL---FKCLLLTGGCTLLHCFVILPVFLTFFPP 795 >gi|66932902 SREBF chaperone protein [Homo sapiens] Length = 1279 Score = 70.1 bits (170), Expect = 1e-11 Identities = 45/182 (24%), Positives = 90/182 (49%), Gaps = 6/182 (3%) Query: 438 VIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAA 497 +I + + Y+++ AY + + D KS+ + LA V+ V S+ +GLC+L G++ Sbjct: 285 LIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLN 344 Query: 498 TTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTA 557 ++ P+L + +G+++V +L + T + + R + L S+ + + Sbjct: 345 GGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKL--RIAQGLSSESWSIMKNMATELGI 402 Query: 558 FFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRRE----DRRLDIFCCF 613 + +PA++ F L A V +V +F + +L F +LS+D+ R E ++RL C Sbjct: 403 ILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACL 462 Query: 614 TS 615 S Sbjct: 463 PS 464 >gi|149274653 patched domain containing 2 [Homo sapiens] Length = 1392 Score = 53.1 bits (126), Expect = 2e-06 Identities = 87/394 (22%), Positives = 152/394 (38%), Gaps = 65/394 (16%) Query: 386 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGY 445 W E +A +++ TYV ++ A+ ST KV T D V R + Sbjct: 415 WEEQRAK--FQSFVVTYVAML----AKQSTSKVQVLYGGT------DLFDYEVRRTFNND 462 Query: 446 LLM--LAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLI-GISFNAATTQVL 502 +L+ ++ +C+ L + + + G+ + LS L L ++ GI + V Sbjct: 463 MLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVA 522 Query: 503 PFLALGVGVDDVFLLAHAFSETGQNKRIPFED---RTGECLKRTGASVALTSISNVTAFF 559 F+ +G+GVDDVF+ + + + ED R ++ G + TS++ A+ Sbjct: 523 AFVIVGIGVDDVFVFINTYRQATH-----LEDPQLRMIHTVQTAGKATFFTSLTTAAAYA 577 Query: 560 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVS 619 IPA+ F L +++V + VL+ PA L + + + +P Sbjct: 578 ANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL------------WSLYLAP--- 622 Query: 620 RVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAE 679 +E T H N + FA Q+ D + E Sbjct: 623 ----LESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEE 678 Query: 680 PRS-EIS-VQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEK 737 P S E+ V V+V+ + L Q +T S L+ Q + H W L S Sbjct: 679 PVSLELGDVSLVSVSPEGL--QPASNTGSRGHLIVQLQELLHH--------WVLWSAV-- 726 Query: 738 HYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVR 771 K++ V++ LF+ +L +SL +R+R Sbjct: 727 ---------KSRWVIVGLFVSILILSLVFASRLR 751 Score = 32.3 bits (72), Expect = 3.4 Identities = 35/167 (20%), Positives = 67/167 (40%), Gaps = 39/167 (23%) Query: 1027 LLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILI 1086 +LL + V+L+ +VC V + W+ G ++ AV + L Sbjct: 1205 ILLLLPVLLSILGIVCLVVTIMYWS----------------------GWEMGAVEAISLS 1242 Query: 1087 ASVGIGVEFTVHVALAFL------------TAIGDKNRRAVLALEHMFAPVLDGAVSTLL 1134 VG V++ VH+ +L A + R + A+ H+ ++ A++T++ Sbjct: 1243 ILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVI 1302 Query: 1135 GVLMLAGSEFDFIVRY--FFAVLAILTILGVLNGLVLLPVLLSFFGP 1179 + L F I + F ++A+ T + +L L + LL P Sbjct: 1303 ATVPLF---FCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAP 1346 >gi|25952134 dispatched A [Homo sapiens] Length = 1524 Score = 50.4 bits (119), Expect = 1e-05 Identities = 29/113 (25%), Positives = 55/113 (48%), Gaps = 5/113 (4%) Query: 505 LALGVGVDDVFLLAHAFSETGQNK-RIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL 563 + +G+G DD F+L ++ T +K + L+ S+ +TS + AF+ + Sbjct: 565 ILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYV 624 Query: 564 IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSP 616 I A+R F + A ++ N+ +++ PA++ + E L+IF CF P Sbjct: 625 SNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKP 673 Score = 41.2 bits (95), Expect = 0.007 Identities = 41/173 (23%), Positives = 79/173 (45%), Gaps = 21/173 (12%) Query: 986 FVEAIEKVRTI---CSNYTSLGLSSYPNGYP-------FLFWEQYIGLRHWLLLFISVVL 1035 F A EK+ ++ S LSS P G F++ L L+ + + + Sbjct: 933 FTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSV 992 Query: 1036 ACTFLVCAVFLLNPWTAGIIVMVLALMTVE-----LFGMMGLIGIKLSAVPVVILIASVG 1090 A F +V LL W II+ + A++++ G + L+G +L+ + V + +VG Sbjct: 993 AVAF---SVMLLTTWN--IIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVG 1047 Query: 1091 IGVEFTVHVALAF-LTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGS 1142 + V+F VH +A+ L D+ + + +L + + + A++T + M+ S Sbjct: 1048 LSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 1100 >gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 855 Score = 47.8 bits (112), Expect = 8e-05 Identities = 67/245 (27%), Positives = 89/245 (36%), Gaps = 32/245 (13%) Query: 1177 FGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEE 1236 F P P +SP L TP P+ PP++ A+PP S + S T S + Sbjct: 380 FLPSPPLSP------LATPPPQAPPAL---ALPPLQA-PPSPPASPPLSPLATPSPQAPN 429 Query: 1237 LRHYEAQQGAGGPAHQVIVEATENPVFAH--STVVHPESR----------HHPPSNPRQQ 1284 Q P V+A +P + S P S+ PPS P Sbjct: 430 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 489 Query: 1285 PHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGAR 1344 P S + PP Q P PP + PPP P A S P++ P Sbjct: 490 PMSPSATPPP--QAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 547 Query: 1345 SHNPRNPASTAMGSSVPGYCQPITTVTAS--ASVTV-AVHPPPVPGPGRNPRG-----GL 1396 + P +P +T + P P+ V S AS T+ A PP PGP + G L Sbjct: 548 ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLAL 607 Query: 1397 CPGYP 1401 PG P Sbjct: 608 APGPP 612 Score = 31.6 bits (70), Expect = 5.8 Identities = 41/164 (25%), Positives = 56/164 (34%), Gaps = 34/164 (20%) Query: 1195 PSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVI 1254 P P PPPS P T SG D + S+ +T EELR Y++ G Sbjct: 609 PGPPPPPS-----RSPSSTLSGPDLAGHSSSATST----PEELRGYDSGPEGGA------ 653 Query: 1255 VEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLP------PGR--------QGQQ 1300 A P A HP + P+ P LP PG + + Sbjct: 654 --AASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEG 711 Query: 1301 PRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGAR 1344 P P G P P + + +G S+R+ P+ AR Sbjct: 712 PESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRS---PKQAR 752 >gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens] Length = 816 Score = 47.8 bits (112), Expect = 8e-05 Identities = 67/245 (27%), Positives = 89/245 (36%), Gaps = 32/245 (13%) Query: 1177 FGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEE 1236 F P P +SP L TP P+ PP++ A+PP S + S T S + Sbjct: 341 FLPSPPLSP------LATPPPQAPPAL---ALPPLQA-PPSPPASPPLSPLATPSPQAPN 390 Query: 1237 LRHYEAQQGAGGPAHQVIVEATENPVFAH--STVVHPESR----------HHPPSNPRQQ 1284 Q P V+A +P + S P S+ PPS P Sbjct: 391 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 450 Query: 1285 PHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGAR 1344 P S + PP Q P PP + PPP P A S P++ P Sbjct: 451 PMSPSATPPP--QAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 508 Query: 1345 SHNPRNPASTAMGSSVPGYCQPITTVTAS--ASVTV-AVHPPPVPGPGRNPRG-----GL 1396 + P +P +T + P P+ V S AS T+ A PP PGP + G L Sbjct: 509 ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLAL 568 Query: 1397 CPGYP 1401 PG P Sbjct: 569 APGPP 573 Score = 35.8 bits (81), Expect = 0.31 Identities = 53/218 (24%), Positives = 72/218 (33%), Gaps = 36/218 (16%) Query: 1179 PYPEVSPANG---LNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSE 1235 P + +PA G + L TPSP PPS + PP + S + SQ T S Sbjct: 279 PRKDAAPALGPLSSSPLATPSPSAPPSP---SAPP--SLQTLPSPPATPPSQATTS---- 329 Query: 1236 ELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPG 1295 G P Q HS + P P+ P L +LPP Sbjct: 330 ----------LGSPTLQA----------THSFLPSPPLSPLATPPPQAPPAL---ALPPL 366 Query: 1296 RQGQQPRRDPPREGL-WPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPAST 1354 + P PP L P P P A + S P + P + P +P++T Sbjct: 367 QAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT 426 Query: 1355 AMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1392 + P P V S + + P P P P Sbjct: 427 PPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 464 Score = 31.6 bits (70), Expect = 5.8 Identities = 41/164 (25%), Positives = 56/164 (34%), Gaps = 34/164 (20%) Query: 1195 PSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVI 1254 P P PPPS P T SG D + S+ +T EELR Y++ G Sbjct: 570 PGPPPPPS-----RSPSSTLSGPDLAGHSSSATST----PEELRGYDSGPEGGA------ 614 Query: 1255 VEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLP------PGR--------QGQQ 1300 A P A HP + P+ P LP PG + + Sbjct: 615 --AASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEG 672 Query: 1301 PRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGAR 1344 P P G P P + + +G S+R+ P+ AR Sbjct: 673 PESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRS---PKQAR 713 >gi|150417989 cyclin K isoform 1 [Homo sapiens] Length = 580 Score = 45.1 bits (105), Expect = 5e-04 Identities = 55/204 (26%), Positives = 69/204 (33%), Gaps = 37/204 (18%) Query: 1193 PTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQ 1252 P P +PPP R PP ++ S+ S Y S E + ++ GP++ Sbjct: 407 PAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMS-------GEGYQSLQSMMKTEGPSYG 459 Query: 1253 VIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWP 1312 + A P AH P H P NP P PP P PP G P Sbjct: 460 ALPPAYGPP--AHL----PYHPHVYPPNPPPPP-----VPPPPASFPPPAIPPPTPGYPP 508 Query: 1313 PPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTA 1372 PP T + P R P A +P G +P P V Sbjct: 509 PP----------PTYNPNFPPPPPRLPPTHAVPPHP------PPGLGLPPASYPPPAVPP 552 Query: 1373 SASVTVAVHPPPVPGPGRNPRGGL 1396 V PPP+P PG P GGL Sbjct: 553 GGQPPV---PPPIPPPGMPPVGGL 573 Score = 32.3 bits (72), Expect = 3.4 Identities = 43/168 (25%), Positives = 53/168 (31%), Gaps = 28/168 (16%) Query: 1255 VEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGR---------QGQQP---- 1301 V+AT+ P HP H PP P + P S G +G Q Sbjct: 391 VDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSM 450 Query: 1302 -RRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSV 1360 + + P G PP Y P + H P N P P + A+ Sbjct: 451 MKTEGPSYGALPPAYGP---PAHLPYHPHVYPPN----PPPPPVPPPPASFPPPAIPPPT 503 Query: 1361 PGYCQPITTVTAS-------ASVTVAVHPPPVPGPGRNPRGGLCPGYP 1401 PGY P T + T AV P P PG G P P P Sbjct: 504 PGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVP 551 >gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 preproprotein [Homo sapiens] Length = 331 Score = 44.3 bits (103), Expect = 9e-04 Identities = 39/133 (29%), Positives = 50/133 (37%), Gaps = 31/133 (23%) Query: 1280 NPRQQPHLDSGSLPPGRQGQQPRRDPPREG--LWPPPYRPRRDAFEISTEGHSGPSNRAR 1337 +PR P G PP + G QP+ PP G PPP R +G P Sbjct: 89 SPRSPPGKPQG--PPPQGGNQPQGPPPPPGKPQGPPPQGGNR------PQGPPPPGKPQG 140 Query: 1338 WGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGP--------G 1389 P+G +S +PR+P G G QP PPP PG G Sbjct: 141 PPPQGDKSRSPRSPPGKPQGPPPQGGNQP-------------QGPPPPPGKPQGPPPQGG 187 Query: 1390 RNPRGGLCPGYPE 1402 + P+G PG P+ Sbjct: 188 KKPQGPPPPGKPQ 200 Score = 36.6 bits (83), Expect = 0.18 Identities = 35/126 (27%), Positives = 48/126 (38%), Gaps = 24/126 (19%) Query: 1288 DSGSLPPGR-QGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGP--RGAR 1344 +S SL G QG P+ +G PPP +P+ + + P GP +G + Sbjct: 27 ESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDK 86 Query: 1345 SHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGP--------GRNPRGGL 1396 S +PR+P G G QP PPP PG G P+G Sbjct: 87 SRSPRSPPGKPQGPPPQGGNQP-------------QGPPPPPGKPQGPPPQGGNRPQGPP 133 Query: 1397 CPGYPE 1402 PG P+ Sbjct: 134 PPGKPQ 139 >gi|112734870 hypothetical protein LOC57648 [Homo sapiens] Length = 1094 Score = 43.5 bits (101), Expect = 0.001 Identities = 47/218 (21%), Positives = 81/218 (37%), Gaps = 44/218 (20%) Query: 1179 PYPEV----SPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLS 1234 P+P+V SP R P P+ P++ A+ PG + S S + QTT++ L Sbjct: 662 PHPKVPAPFSPPPSKPRSPNPAA---PALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQ 718 Query: 1235 EELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPP 1294 E ++ ++P + P +HPP P ++P + + Sbjct: 719 ES----------------PVISKDQSPPPS------PPPSYHPPPPPTKKPEVVVEAPSA 756 Query: 1295 GRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPAST 1354 ++P +DP WPPP P + ++S P S P P+ + Sbjct: 757 SETAEEPLQDPN----WPPPPPPAPEEQDLSMADFPPPEEAF----FSVASPEPAGPSGS 808 Query: 1355 AMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNP 1392 S P ++S++ + + PP P P P Sbjct: 809 PELVSSP-------AASSSSATALQIQPPGSPDPPPAP 839 >gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] Length = 416 Score = 42.7 bits (99), Expect = 0.003 Identities = 39/142 (27%), Positives = 50/142 (35%), Gaps = 31/142 (21%) Query: 1271 PESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREG--LWPPPYRPRRDAFEISTEG 1328 P + P P P G PP + G QP+ PP G PPP + +G Sbjct: 40 PPQGGNKPQGPPSPPGKPQG--PPPQGGNQPQGPPPPPGKPQGPPPQGGNK------PQG 91 Query: 1329 HSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGP 1388 P P+G +S +PR+P G G QP PPP PG Sbjct: 92 PPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQP-------------QGPPPPPGK 138 Query: 1389 --------GRNPRGGLCPGYPE 1402 G P+G PG P+ Sbjct: 139 PQGPPPQGGNKPQGPPPPGKPQ 160 Score = 32.7 bits (73), Expect = 2.6 Identities = 37/141 (26%), Positives = 48/141 (34%), Gaps = 39/141 (27%) Query: 1273 SRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREG--LWPPPYRPRRDAFEISTEGHS 1330 S PP P+ PP + G QP+ PP G PPP + +G Sbjct: 172 SSRSPPGKPQG---------PPPQGGNQPQGPPPPPGKPQGPPPQGGNK------PQGPP 216 Query: 1331 GPSNRARWGPRG-ARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGP- 1388 P P+G +S + R+P G G QP PPP PG Sbjct: 217 PPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQP-------------QGPPPPPGKP 263 Query: 1389 -------GRNPRGGLCPGYPE 1402 G P+G PG P+ Sbjct: 264 QGPPPQGGNKPQGPPPPGKPQ 284 Score = 32.7 bits (73), Expect = 2.6 Identities = 41/169 (24%), Positives = 57/169 (33%), Gaps = 50/169 (29%) Query: 1271 PESRHHPPSNPRQQP----HLDSGSLPPGR-QGQQPR--------RDPPREGLWPPPY-- 1315 P+ PP P+ P + G PPG+ QG P+ R PP + PPP Sbjct: 191 PQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGG 250 Query: 1316 -----------RPRRDAFEISTEGHSGPSNRARWGP---RGARSHNPRNPASTAMGSSVP 1361 +P+ + + P GP G++S + R+P G Sbjct: 251 NQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQ 310 Query: 1362 GYCQPITTVTASASVTVAVHPPPVPGP--------GRNPRGGLCPGYPE 1402 G QP PPP PG G P+G PG P+ Sbjct: 311 GGNQP-------------QGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ 346 >gi|224451135 splicing factor, arginine/serine-rich 15 isoform 3 [Homo sapiens] Length = 1125 Score = 42.4 bits (98), Expect = 0.003 Identities = 47/181 (25%), Positives = 64/181 (35%), Gaps = 41/181 (22%) Query: 1181 PEVSPANGLNRLPTPSPEP----------PPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1230 P P L R P P P PP FAMPP H G + + Sbjct: 840 PPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGM 899 Query: 1231 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1290 GL G GGP + + R PP P+QQP + Sbjct: 900 PGLGGP------GPGPGGPEDR-------------------DGRQQPPQQPQQQPQPQAP 934 Query: 1291 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPR--GARSHNP 1348 P +Q QQP PP + P +P++ + + +SG ++ R+G R G R N Sbjct: 935 QQPQQQQQQQP---PPSQQPPPTQQQPQQFRNDNRQQFNSG-RDQERFGRRSFGNRVEND 990 Query: 1349 R 1349 R Sbjct: 991 R 991 >gi|224451133 splicing factor, arginine/serine-rich 15 isoform 2 [Homo sapiens] Length = 1132 Score = 42.4 bits (98), Expect = 0.003 Identities = 47/181 (25%), Positives = 64/181 (35%), Gaps = 41/181 (22%) Query: 1181 PEVSPANGLNRLPTPSPEP----------PPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1230 P P L R P P P PP FAMPP H G + + Sbjct: 847 PPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGM 906 Query: 1231 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1290 GL G GGP + + R PP P+QQP + Sbjct: 907 PGLGGP------GPGPGGPEDR-------------------DGRQQPPQQPQQQPQPQAP 941 Query: 1291 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPR--GARSHNP 1348 P +Q QQP PP + P +P++ + + +SG ++ R+G R G R N Sbjct: 942 QQPQQQQQQQP---PPSQQPPPTQQQPQQFRNDNRQQFNSG-RDQERFGRRSFGNRVEND 997 Query: 1349 R 1349 R Sbjct: 998 R 998 >gi|40789229 splicing factor, arginine/serine-rich 15 isoform 1 [Homo sapiens] Length = 1147 Score = 42.4 bits (98), Expect = 0.003 Identities = 47/181 (25%), Positives = 64/181 (35%), Gaps = 41/181 (22%) Query: 1181 PEVSPANGLNRLPTPSPEP----------PPSVVRFAMPPGHTHSGSDSSDSEYSSQTTV 1230 P P L R P P P PP FAMPP H G + + Sbjct: 862 PPGMPPPHLQRFPLMPPRPMPPHMMHRGPPPGPGGFAMPPPHGMKGPFPPHGPFVRPGGM 921 Query: 1231 SGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSG 1290 GL G GGP + + R PP P+QQP + Sbjct: 922 PGLGGP------GPGPGGPEDR-------------------DGRQQPPQQPQQQPQPQAP 956 Query: 1291 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPR--GARSHNP 1348 P +Q QQP PP + P +P++ + + +SG ++ R+G R G R N Sbjct: 957 QQPQQQQQQQP---PPSQQPPPTQQQPQQFRNDNRQQFNSG-RDQERFGRRSFGNRVEND 1012 Query: 1349 R 1349 R Sbjct: 1013 R 1013 >gi|4826998 splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) [Homo sapiens] Length = 707 Score = 42.4 bits (98), Expect = 0.003 Identities = 43/151 (28%), Positives = 58/151 (38%), Gaps = 28/151 (18%) Query: 1277 PPSNPRQQPHLDSGSLPPGRQG---QQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPS 1333 PP P QQ PP +Q Q P P + PPP P +D+ + GP+ Sbjct: 61 PPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPP--PPQDSSKPVVAQGPGPA 118 Query: 1334 NRARWGPRGARSHNPRNPAST----------------AMGSSVPGYCQPITTVTASASVT 1377 P + S P P ++ A+ S+ PG P T ++ T Sbjct: 119 PGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPG-APPPTPPSSGVPTT 177 Query: 1378 V--AVHPPP----VPGPGRNPRGGLCPGYPE 1402 A PPP VPGPG P+ G PG P+ Sbjct: 178 PPQAGGPPPPPAAVPGPGPGPKQGPGPGGPK 208 Score = 33.1 bits (74), Expect = 2.0 Identities = 45/178 (25%), Positives = 55/178 (30%), Gaps = 23/178 (12%) Query: 1179 PYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELR 1238 P P P P P P V + P S +S S + SG Sbjct: 87 PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSG------ 140 Query: 1239 HYEAQQGAG-GPAHQVIVEATENPVFA-------HSTVVHPESRHHPPSNPRQQPHLDSG 1290 A G+G GP T P A P PP P P G Sbjct: 141 ---APPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVP----G 193 Query: 1291 SLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNP 1348 P +QG P P+ G P +P + GH P +R PRG R H+P Sbjct: 194 PGPGPKQGPGP--GGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHP 249 Score = 32.0 bits (71), Expect = 4.4 Identities = 55/226 (24%), Positives = 72/226 (31%), Gaps = 44/226 (19%) Query: 1178 GPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEEL 1237 GP P + P + P P+ PP PP H + S+ + Sbjct: 55 GPKPPIPPPPPHQQQQQPPPQQPPP----QQPPPHQPPPHPQPHQQQQPPPPPQDSSKPV 110 Query: 1238 RHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSN---PRQQPHLDSGSLPP 1294 QG GPA V + P + + P + PP + P P S PP Sbjct: 111 ----VAQGP-GPAPGV---GSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPP 162 Query: 1295 GRQGQQPRRD-----PPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPR 1349 G P PP+ G PPP + G GP + GP G + Sbjct: 163 GAPPPTPPSSGVPTTPPQAGGPPPP--------PAAVPG-PGPGPKQGPGPGGPK----- 208 Query: 1350 NPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGG 1395 G +PG +P S T HP P G PRGG Sbjct: 209 -------GGKMPGGPKPGGGPGLS---TPGGHPKPPHRGGGEPRGG 244 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.136 0.419 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 60,972,589 Number of Sequences: 37866 Number of extensions: 3174548 Number of successful extensions: 16159 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 37 Number of HSP's successfully gapped in prelim test: 335 Number of HSP's that attempted gapping in prelim test: 14726 Number of HSP's gapped (non-prelim): 1594 length of query: 1446 length of database: 18,247,518 effective HSP length: 115 effective length of query: 1331 effective length of database: 13,892,928 effective search space: 18491487168 effective search space used: 18491487168 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.