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Search of human proteins with 134142826
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|134142826 pericentriolar material 1 [Homo sapiens]
(2024 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|134142826 pericentriolar material 1 [Homo sapiens] 4003 0.0
gi|71061468 centromere protein E [Homo sapiens] 72 6e-12
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 68 8e-11
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 68 8e-11
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 68 8e-11
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 68 8e-11
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 66 3e-10
gi|38044112 restin isoform b [Homo sapiens] 66 4e-10
gi|4506751 restin isoform a [Homo sapiens] 66 4e-10
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 64 1e-09
gi|118498356 kinectin 1 isoform a [Homo sapiens] 59 4e-08
gi|33620775 kinectin 1 isoform a [Homo sapiens] 59 4e-08
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 59 6e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 58 1e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 58 1e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 58 1e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 58 1e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 58 1e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 58 1e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 58 1e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 58 1e-07
gi|115511012 coiled-coil domain containing 136 [Homo sapiens] 58 1e-07
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 57 1e-07
gi|32698688 citron [Homo sapiens] 56 4e-07
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 55 5e-07
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 55 5e-07
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 55 7e-07
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 55 9e-07
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 55 9e-07
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 54 1e-06
>gi|134142826 pericentriolar material 1 [Homo sapiens]
Length = 2024
Score = 4003 bits (10382), Expect = 0.0
Identities = 2024/2024 (100%), Positives = 2024/2024 (100%)
Query: 1 MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRV 60
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRV
Sbjct: 1 MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRV 60
Query: 61 TNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQAELEKLKQRINFSDLDQRSIGSD 120
TNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQAELEKLKQRINFSDLDQRSIGSD
Sbjct: 61 TNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQAELEKLKQRINFSDLDQRSIGSD 120
Query: 121 SQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTSPPNRETIGSAQCKELFASALS 180
SQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTSPPNRETIGSAQCKELFASALS
Sbjct: 121 SQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTSPPNRETIGSAQCKELFASALS 180
Query: 181 NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLT 240
NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLT
Sbjct: 181 NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLT 240
Query: 241 HLIDHLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQ 300
HLIDHLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQ
Sbjct: 241 HLIDHLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQ 300
Query: 301 AALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA 360
AALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA
Sbjct: 301 AALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA 360
Query: 361 VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTL 420
VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTL
Sbjct: 361 VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTL 420
Query: 421 RDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESEN 480
RDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESEN
Sbjct: 421 RDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESEN 480
Query: 481 EGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE 540
EGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE
Sbjct: 481 EGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE 540
Query: 541 NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPS 600
NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPS
Sbjct: 541 NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPS 600
Query: 601 LDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKIN 660
LDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKIN
Sbjct: 601 LDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKIN 660
Query: 661 RLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKT 720
RLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKT
Sbjct: 661 RLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKT 720
Query: 721 QKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASV 780
QKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASV
Sbjct: 721 QKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASV 780
Query: 781 GNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRR 840
GNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRR
Sbjct: 781 GNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRR 840
Query: 841 KQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE 900
KQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE
Sbjct: 841 KQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE 900
Query: 901 EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFS 960
EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFS
Sbjct: 901 EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFS 960
Query: 961 ADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKKQLDFSVSICQTL 1020
ADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKKQLDFSVSICQTL
Sbjct: 961 ADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKKQLDFSVSICQTL 1020
Query: 1021 MQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLN 1080
MQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLN
Sbjct: 1021 MQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLN 1080
Query: 1081 ELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMN 1140
ELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMN
Sbjct: 1081 ELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMN 1140
Query: 1141 FSPLFPSNFGDFSQNISTPSEQQQPLAQNSSGKTEYMAFPKPFESSSSIGAEKPRNKKLP 1200
FSPLFPSNFGDFSQNISTPSEQQQPLAQNSSGKTEYMAFPKPFESSSSIGAEKPRNKKLP
Sbjct: 1141 FSPLFPSNFGDFSQNISTPSEQQQPLAQNSSGKTEYMAFPKPFESSSSIGAEKPRNKKLP 1200
Query: 1201 EEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLES 1260
EEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLES
Sbjct: 1201 EEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLES 1260
Query: 1261 FSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESAS 1320
FSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESAS
Sbjct: 1261 FSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESAS 1320
Query: 1321 MSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSETGSDFSMFEA 1380
MSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSETGSDFSMFEA
Sbjct: 1321 MSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSETGSDFSMFEA 1380
Query: 1381 LRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK 1440
LRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK
Sbjct: 1381 LRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK 1440
Query: 1441 GENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSS 1500
GENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSS
Sbjct: 1441 GENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSS 1500
Query: 1501 NFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVN 1560
NFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVN
Sbjct: 1501 NFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVN 1560
Query: 1561 NLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQL 1620
NLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQL
Sbjct: 1561 NLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQL 1620
Query: 1621 LTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVL 1680
LTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVL
Sbjct: 1621 LTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVL 1680
Query: 1681 FNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDK 1740
FNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDK
Sbjct: 1681 FNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDK 1740
Query: 1741 DKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINLSKAETQALTNYGSGE 1800
DKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINLSKAETQALTNYGSGE
Sbjct: 1741 DKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINLSKAETQALTNYGSGE 1800
Query: 1801 DENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATS 1860
DENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATS
Sbjct: 1801 DENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATS 1860
Query: 1861 KNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKE 1920
KNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKE
Sbjct: 1861 KNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKE 1920
Query: 1921 VKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEAD 1980
VKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEAD
Sbjct: 1921 VKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEAD 1980
Query: 1981 LRKKMVEEEQKNHLSGEICEMQTEELAGNSETLKEPETVGAQSI 2024
LRKKMVEEEQKNHLSGEICEMQTEELAGNSETLKEPETVGAQSI
Sbjct: 1981 LRKKMVEEEQKNHLSGEICEMQTEELAGNSETLKEPETVGAQSI 2024
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 72.0 bits (175), Expect = 6e-12
Identities = 149/798 (18%), Positives = 316/798 (39%), Gaps = 93/798 (11%)
Query: 1286 ASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAK 1345
A + D +S + + +LK ++K + M + + +S+ + + ++ +
Sbjct: 630 AETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKE 689
Query: 1346 VFSRKNH---------EQLEKIIKCN-----RSTEISSETGSDFSMFEALRDTIYSEVAT 1391
+ S N ++ K + CN + T++ E + EALR+ +
Sbjct: 690 LQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVI----- 744
Query: 1392 LISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGT 1451
L+S+ +S P + L E+Q + L+ + + SE K V+ +
Sbjct: 745 LLSELKSLPSEVERLRKEIQD------KSEELHIITSEKDKLFSEVVHKESRVQGLLEEI 798
Query: 1452 WIASNSELTPSESLATTDDE-----TFEKNFERETHKISEQNDADNASVLSVSSNFEPFA 1506
+ T + +TD E T +FE++ + E+N+ N ++++S + F
Sbjct: 799 GKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFD 858
Query: 1507 TDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETP 1566
+ LG L ++E + + E + M +E+ D +T+ +E
Sbjct: 859 SS-LGALKTELSYKTQELQE--KTREVQERLNEMEQLKEQLENRD-----STLQTVEREK 910
Query: 1567 VIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAI---------------------MKEVI 1605
+ QQ + EV T+ + D +QL ++ ++ +
Sbjct: 911 TLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNAL 970
Query: 1606 PFLKEHMDEV--CSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLG-SILQDSLAKFAG 1662
LK+H + + S++ V R L + + E+K+ +F K +G QD AK
Sbjct: 971 ESLKQHQETINTLKSKISEEVSRN-LHMEENTGETKD--EFQQKMVGIDKKQDLEAKNTQ 1027
Query: 1663 RKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAK 1722
D ++ ++E +F+ + +Q + + I K++ K ++ + +E
Sbjct: 1028 TLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEEL 1087
Query: 1723 RILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEED-EESEGCPV 1781
R+L D EI ++K+ K+ + S D V + ++ + +E + +
Sbjct: 1088 RLLGDELKKQQEIVAQEKNH---AIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLL 1144
Query: 1782 SINLSKAETQALTNYGSG---EDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQV 1838
++ +E Q N E +N++ +E E +++ L N E + + +V
Sbjct: 1145 NVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKV 1204
Query: 1839 LQRDFKKTAESKNVPLE---REATSKNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTV 1895
L ++ +K+ E++ L RE + Q +K ++++ E ++ ++ S T
Sbjct: 1205 L-KELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTA 1263
Query: 1896 D----------STQQPNPLPLRLPEMEPLVPRVKEVKSAQETPE--SSLAGSPDTESPVL 1943
T+ +P+ L E + L+P VKEV QET L T+
Sbjct: 1264 QIINTQDLEKSHTKLQEEIPV-LHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTT 1322
Query: 1944 VNDYEAESGNISQK---SDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKNHLSGEICE 2000
+ E E +++K S EE ++ TI +++ ++E + L+ +I E
Sbjct: 1323 LARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLA-KIQE 1381
Query: 2001 MQTEELAGNSETLKEPET 2018
Q+++ + K+ ET
Sbjct: 1382 SQSKQEQSLNMKEKDNET 1399
Score = 59.3 bits (142), Expect = 4e-08
Identities = 148/800 (18%), Positives = 311/800 (38%), Gaps = 140/800 (17%)
Query: 89 MSQMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQI 148
+ Q+ Q E ++LK I+ D +I + Q R N L ++++ N L +I
Sbjct: 934 LKQLQESLQIERDQLKSDIH--DTVNMNIDTQEQLR----NALESLKQHQETINTLKSKI 987
Query: 149 NTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSR 208
+ S++ ET Q K + + +N Q D + +E + +
Sbjct: 988 SEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFS 1047
Query: 209 LVQ--------IRDYITKASSMREDLVEKNERSA-NVERLTHLIDHLKEQEKSYMKFLKK 259
L+Q + I + ++ DL E E + N E L L D LK+Q++
Sbjct: 1048 LIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQE-------- 1099
Query: 260 ILARDPQQEPMEEIENLKKQHDLLK---RMLQQQEQLRALQGRQAALLALQHKAEQAIAV 316
I+A+ E+ +KK+ +L + R+ + +E+L+ + LQ K +Q + V
Sbjct: 1100 IVAQ-------EKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQ------LQEKQQQLLNV 1146
Query: 317 MDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTRE 376
++ SE+ +++N+ I+ N+L++ + LT E
Sbjct: 1147 QEEM---------------SEMQKKINE-IENLKNELKNKE---------------LTLE 1175
Query: 377 VSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSV 436
++ + +++L + + +++ + ++++ + +L T RD HL + +
Sbjct: 1176 HMETERLELAQKLNEN----YEEVKSITKERKVLKELQKSFETERD-HLRGYIREIEATG 1230
Query: 437 DQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEV 496
Q A + L + L SV TA +++ + E + H E++ L+E
Sbjct: 1231 LQTKEELKIAHIHLKEHQE-TIDELRRSVSEKTAQIINTQDLE-KSHTKLQEEIPVLHEE 1288
Query: 497 RKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVAST 556
++ L ++E+ E +++ KD T + I ++
Sbjct: 1289 QELLPNVKEVSETQETMNELELLTEQSTTKDSTT--------------LARIEMERLRLN 1334
Query: 557 WNEVNSHSNAQCVSNNRDG-RTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHV 615
S + ++ RD +T+ E+ + ++ +L + +QE +
Sbjct: 1335 EKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKE----HIRETLAKIQESQSKQEQSL 1390
Query: 616 AQGEDDEEEEE---EAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQL 672
E D E + E E+ ++L ++ E ++ + K L++L
Sbjct: 1391 NMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRL 1450
Query: 673 QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTK--------QNSNNTRGNANKTQKDT 724
Q+ V + D + + A +L+ EE+ K Q N ++K+T
Sbjct: 1451 QE-VLQSESDQLKENIKEIVAKHLE----TEEELKVAHCCLKEQEETINELRVNLSEKET 1505
Query: 725 ----------GVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQ 774
+N+K + K E +++Q +KQ+ E +QEK+ L+ +
Sbjct: 1506 EISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISE-------VQEKVNELKQFKEHRK 1558
Query: 775 LSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLRE 834
+++ + +K M +T+ +Q E + E E+ V L E R+
Sbjct: 1559 AKDSALQSIESK--MLELTNRLQESQEEIQI--MIKEKEEMKRVQEALQIE-------RD 1607
Query: 835 ELRQRRKQLEALMAEHQRRQ 854
+L++ K++ A M E Q ++
Sbjct: 1608 QLKENTKEIVAKMKESQEKE 1627
Score = 51.6 bits (122), Expect = 8e-06
Identities = 113/604 (18%), Positives = 249/604 (41%), Gaps = 72/604 (11%)
Query: 106 RINFSDLDQRSIGSDSQGRATAANNKRQ-----LSENRKPFNFLPMQINTNKSKDASTSP 160
R+N S+ + S Q + A N+K Q + E + FN + K +
Sbjct: 1497 RVNLSEKETEI--STIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFK 1554
Query: 161 PNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKAS 220
+R+ SA ++ + +L E R + + E QI+ + + + +A
Sbjct: 1555 EHRKAKDSA------LQSIESKML------ELTNRLQESQEEIQIMIKEKEEMKRVQEAL 1602
Query: 221 SMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQH 280
+ D +++N + ++ +KE ++ +FLK + A + QE M EIE+LK+Q
Sbjct: 1603 QIERDQLKENTKE--------IVAKMKESQEKEYQFLK-MTAVNETQEKMCEIEHLKEQF 1653
Query: 281 DLLKRMLQ--QQEQLRALQGRQAALLALQH--KAEQAIAVMDDSVVAETAGSLSGVSITS 336
+ K L+ + E +R Q L ++ K + +++++ E + T
Sbjct: 1654 ETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETI 1713
Query: 337 ELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQSRK--PSASERLPDEKV 394
+ E + ++ H L++ Q D R S T E+S +K +++ L + +
Sbjct: 1714 TRDLEKQEELKIVHMHLKEHQETI--DKLRGIVS-EKTNEISNMQKDLEHSNDALKAQDL 1770
Query: 395 ELFSKMRV----LQEKKQKMDKLLGELHTLRD------QHLNNSSSSPQRSVDQRSTSAP 444
++ ++R+ L+E+++ +DKL G + D + L NS++ Q + + +
Sbjct: 1771 KIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEH 1830
Query: 445 SASVGLAPVVN------GESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRK 498
+ L VN E L + + +L S+ E EN LN ++KL + E K
Sbjct: 1831 QL-ITLKKDVNETQKKVSEMEQLKKQIKDQSLTL-SKLEIEN---LNLAQKLHENLEEMK 1885
Query: 499 RLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTWN 558
+ + R+ + E+T + D + E+ ++ + + E E + + ++ V
Sbjct: 1886 SVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLRE 1945
Query: 559 EVNSHS-NAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQ 617
+++ + + + D +I ++ L + ++ + + E
Sbjct: 1946 KISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEM------ 1999
Query: 618 GEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVA 677
E+ +++ E + +S S+ L + E E +I + + +LR++++ +
Sbjct: 2000 ----EQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLE---EIRIVAKERDELRRIKESLK 2052
Query: 678 MVQD 681
M +D
Sbjct: 2053 MERD 2056
Score = 48.9 bits (115), Expect = 5e-05
Identities = 153/828 (18%), Positives = 320/828 (38%), Gaps = 142/828 (17%)
Query: 117 IGSDSQGRATAANNKRQLSENRKPFNFLPMQINTN-KSKDASTSPPNRETIGSAQCKELF 175
IG AT +N + + + F L M K N+E + ++ + F
Sbjct: 798 IGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKF 857
Query: 176 AS---ALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNER 232
S AL +L Q +E R E + ++ + Q+++ + S + + + E+
Sbjct: 858 DSSLGALKTELSYKTQELQEKTR-----EVQERLNEMEQLKEQLENRDSTLQTV--EREK 910
Query: 233 SANVERLTHLIDHLKE--QEKSYMKFLKKILARDPQQEPMEEIENLKKQ-HDLLKRMLQQ 289
+ E+L ++ +K QEK +K L++ L + Q LK HD + +
Sbjct: 911 TLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ--------LKSDIHDTVNMNIDT 962
Query: 290 QEQLR-ALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQR 348
QEQLR AL+ + QH ++ I + + E + +L T E +E
Sbjct: 963 QEQLRNALESLK------QH--QETINTLKSKISEEVSRNLHMEENTGETKDEF------ 1008
Query: 349 FHNQLRDSQPPAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQ 408
Q V +++Q T+ ++ K + + +++ ++FS ++ E +Q
Sbjct: 1009 --------QQKMVGIDKKQDLEAKNTQTLTADVKDN---EIIEQQRKIFSLIQEKNELQQ 1057
Query: 409 KMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYP 468
++ ++ E L+ N + + N E L
Sbjct: 1058 MLESVIAEKEQLKTDLKENIEMT---------------------IENQEELRLLGDELKK 1096
Query: 469 TASLVSQNES---ENEGHLNPS-----EKLQKLNEVRKRLNELRE-LVHYYEQTSDMMTD 519
+V+Q ++ + EG L+ + E +KL E ++L E ++ L++ E+ S+M
Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKK 1156
Query: 520 AVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVN 579
E + E EH +E + ++A NE N + +++
Sbjct: 1157 INEIENLKNELKNKELTLEHMETERL------ELAQKLNE-----------NYEEVKSIT 1199
Query: 580 SNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLS 639
++ ++ L + + R +EI A G +EE + ++ L
Sbjct: 1200 KERKV-------LKELQKSFETERDHLRGYIREIE-ATGLQTKEELK------IAHIHLK 1245
Query: 640 SHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDF 699
H+ ++ + +E +I ++ +LQ+ + ++ ++ N+ +
Sbjct: 1246 EHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQEL-------LPNVKEV 1298
Query: 700 YPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDI 759
+E + T + K E R + E K Q+ Q E+K L +ER L I
Sbjct: 1299 SETQETMNELELLTEQSTTKDSTTLARIEMERLRLNE-KFQESQEEIKSLTKERDNLKTI 1357
Query: 760 QEKIQALQTACPD-LQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSV-----FEPE 813
+E ++ + ++ + A + +K+ + + + + T+K V F+P+
Sbjct: 1358 KEALEVKHDQLKEHIRETLAKIQESQSKQ-----EQSLNMKEKDNETTKIVSEMEQFKPK 1412
Query: 814 DSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSE 873
DS+++ E+ EM L + L++ +++++ E Q L E + L+ + E
Sbjct: 1413 DSALLRIEI--EMLG---LSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKE 1467
Query: 874 NLCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEE 921
+ ++ E +A C L E+ + ++E V E+E E
Sbjct: 1468 IVAKHLETEEELKVA------HCCLKEQEET---INELRVNLSEKETE 1506
Score = 47.4 bits (111), Expect = 1e-04
Identities = 137/705 (19%), Positives = 273/705 (38%), Gaps = 122/705 (17%)
Query: 91 QMSVPEQAELEKLKQRINFSDL-DQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQIN 149
Q +P E+ + ++ +N +L ++S DS A + +L+E Q +
Sbjct: 1289 QELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEK--------FQES 1340
Query: 150 TNKSKDASTSPPNRETIGSA------QCKELFASALSNDLLQNCQVSEEDGRG--EPAME 201
+ K + N +TI A Q KE L+ +Q Q +E E E
Sbjct: 1341 QEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAK--IQESQSKQEQSLNMKEKDNE 1398
Query: 202 SSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKE--QEKSYMKFLKK 259
+++IVS + Q + K S++ +E S +RL D +K +EK ++ L++
Sbjct: 1399 TTKIVSEMEQFKP---KDSALLRIEIEMLGLS---KRLQESHDEMKSVAKEKDDLQRLQE 1452
Query: 260 ILARDPQQ--EPMEEI--------ENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHK 309
+L + Q E ++EI E LK H LK + +LR + ++ K
Sbjct: 1453 VLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQK 1512
Query: 310 AEQAIAVMDDSVVAETAGSLSGVSIT--SELNEELNDLIQ-RFHNQLRDSQPPAVPDNRR 366
+AI + + E +I SE+ E++N+L Q + H + +DS ++
Sbjct: 1513 QLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSI----- 1567
Query: 367 QAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLN 426
+++ L LT + +S++ +++++ ++K++M ++ L RDQ
Sbjct: 1568 ESKMLELTNRLQESQE----------------EIQIMIKEKEEMKRVQEALQIERDQLKE 1611
Query: 427 NSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENE----G 482
N+ + + + Y + + NE++ +
Sbjct: 1612 NTKEIVAKMKESQEKE------------------------YQFLKMTAVNETQEKMCEIE 1647
Query: 483 HLNPSEKLQKLN--EVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE 540
HL + QKLN + L +++H + +T ++ R EET + E D E
Sbjct: 1648 HLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKE 1707
Query: 541 N-SEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPP 599
N E +T Q ++ + + + R + +N EI+N + +
Sbjct: 1708 NLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTN-EISNMQKDLEHSNDALK 1766
Query: 600 SLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKI 659
+ D + ++E+ +A E++E + G+ + D +A+ ++KI
Sbjct: 1767 AQDLKI----QEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKI 1822
Query: 660 NRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANK 719
L A + +L + + +D + Q +S E+ KQ K
Sbjct: 1823 QELKANEHQL------ITLKKDVNETQKKVSEM----------EQLKKQI---------K 1857
Query: 720 TQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQ 764
Q T + KL + E+K + +ER L ++E ++
Sbjct: 1858 DQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLK 1902
Score = 42.0 bits (97), Expect = 0.006
Identities = 118/684 (17%), Positives = 253/684 (36%), Gaps = 97/684 (14%)
Query: 360 AVPDNRRQAESLSLTREVSQSRK--PSASERLPDEKVELFSKMRVLQEKKQKMDKLLGEL 417
A+ ++ + + L E+S + A D + EL SK+ +L+EK+ ++ KL +
Sbjct: 539 ALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYI 598
Query: 418 HTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNE 477
+ + +++ S S++ + + + E+ +L +
Sbjct: 599 DSQKLENIKMDLSYSLESIEDPKQMKQT-------LFDAETVAL---------------D 636
Query: 478 SENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDS 537
++ E SE L E+++++ EL E + + +K + E E S
Sbjct: 637 AKRESAFLRSENL----ELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQS 692
Query: 538 EHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRD-GRTVNSNCEINNRSAANIRALN 596
+T++ + +V + N + D + +N E N + L+
Sbjct: 693 AFNEITKLTSLIDGKVPK-----DLLCNLELEGKITDLQKELNKEVEENEALREEVILLS 747
Query: 597 MPPSLDCRYNR------EGEQEIHVAQGEDDEEEEEEA----------EEEGVSGASLSS 640
SL R + +E+H+ E D+ E EE G + L++
Sbjct: 748 ELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLAT 807
Query: 641 HRSSLVDEHPE-------DAEFEQKINRLMAAKQKLRQ-LQDLVAMVQDDDAAQGVISAS 692
+S+ E +FEQK ++ +++ Q + +L Q D++ G +
Sbjct: 808 TQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTE 867
Query: 693 AS-NLDDFYPAEEDTKQNSNNTRGNANKTQ-KDTGVNEKAREK-FYEAKLQQQQRELKQL 749
S + + ++ N + + +D+ + REK KLQQ E+K L
Sbjct: 868 LSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTL 927
Query: 750 QEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSV 809
+E+ L +QE +LQ L+ N + ++ QH+
Sbjct: 928 TQEKDDLKQLQE---SLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQ------- 977
Query: 810 FEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRS 869
E + + +++ E+ R+ + E + + + + M ++Q L + +L +
Sbjct: 978 ---ETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQ---TLTA 1031
Query: 870 DGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIV------RTDEEEEEEQ 923
D +N QQ + +L +E +E + E ++ +TD +E E
Sbjct: 1032 DVKDNEIIEQQRKI------------FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM 1079
Query: 924 DASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQEN 983
+ + + +E + K S + + + + S Q QE
Sbjct: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
Query: 984 LRWVSELSYVEEKEQWQEQINQLK 1007
+ + L+ EE + Q++IN+++
Sbjct: 1140 QQQL--LNVQEEMSEMQKKINEIE 1161
Score = 37.0 bits (84), Expect = 0.20
Identities = 96/518 (18%), Positives = 205/518 (39%), Gaps = 74/518 (14%)
Query: 1515 IHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQ 1574
IHL + + E R +E T +II D + T + EE PV+
Sbjct: 1242 IHLKEHQETIDELRRSVSEK--------TAQIINTQDLEKSHTKLQ--EEIPVLHEEQEL 1291
Query: 1575 QP-VSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQ 1633
P V EVS + + L Q + K+ + M+ + ++ + + +LT+
Sbjct: 1292 LPNVKEVSETQETMNELELLTEQ--STTKDSTTLARIEMERLRLNEKFQESQEEIKSLTK 1349
Query: 1634 QNDESK---EFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKLM 1690
+ D K E ++ H QL ++++LAK + K + L ++ + NE K++
Sbjct: 1350 ERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQ-EQSLNMKEKD---NETT--KIV 1403
Query: 1691 QDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQ 1750
+++ + +IE G+ +KR+ E H E+ K+KD+ + +++
Sbjct: 1404 SEMEQFKPKDSALLRIEIEMLGL-------SKRLQESHD----EMKSVAKEKDDLQRLQE 1452
Query: 1751 TQTSEVYDGPKNVRSDISDQEEDEE----SEGC---------PVSINLSKAETQALTNYG 1797
SE +N++ ++ E EE + C + +NLS+ ET+ T
Sbjct: 1453 VLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQK 1512
Query: 1798 SGED-----ENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFK-KTAESKN 1851
E +N+ +E+ E EE +++ + + E + E +D ++ ESK
Sbjct: 1513 QLEAINDKLQNKIQEIYEKEE-QFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKM 1571
Query: 1852 VPLEREATSKNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEM 1911
+ L ++ +K E+ + + A E ++T++ + ++ E
Sbjct: 1572 LELTNRLQESQEEIQIMIKE-----KEEMKRVQEALQIERDQLKENTKE---IVAKMKES 1623
Query: 1912 EPLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPL 1971
+ + ++ + ET E E L +E + N+ ++ E++ L
Sbjct: 1624 QEKEYQFLKMTAVNETQEKM------CEIEHLKEQFETQKLNLEN-------IETENIRL 1670
Query: 1972 KLTIYSEADLRKKMVEEEQKNHLSGEICEMQTEELAGN 2009
++ + + + +E E +++ ++L N
Sbjct: 1671 TQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKEN 1708
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 68.2 bits (165), Expect = 8e-11
Identities = 185/939 (19%), Positives = 370/939 (39%), Gaps = 171/939 (18%)
Query: 218 KASSMREDLVEKNERSANVERL--------THLIDHLKEQEKSYMKF--LKKILARDPQQ 267
+ S + +L E+ E++ N+ +L + L LK++EKS + LK+ L D
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS- 1065
Query: 268 EPMEEIENLKKQHDLLKRMLQQQEQ----------------------LRALQGRQAALL- 304
+ E+I +L+ Q LK L ++E+ +R L+G + L
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125
Query: 305 ------ALQHKAEQAIAVMDDSVVA---ETAGSLSGVSITSELN----EELNDLIQRFHN 351
A ++KAE+ + + + A E +L + EL +E+ L +
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 352 QLRDSQPPAVPDNRRQAESLS-LTREVSQSRKPSAS-----ERLPDEKVELFSKMRVLQE 405
+ R + ++ A+++ LT ++ Q ++ A+ + L E +L ++RVL +
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245
Query: 406 KKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQ------RSTSAPSASVGLAPVVNGESN 459
KQ+++ +L + Q L + S +R+ + + + + G+ G++
Sbjct: 1246 AKQEVEHKKKKLEA-QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 460 SLTSSVPYPTASLVSQNE---SENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDM 516
L V ++ L E E LN S KL++L E R L + + +Q +
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 517 MTDAVNENRKDEETEESEYDSEHENSEP--------VTNIRNP--QVASTWNEVNSHSNA 566
+N D + + ++ S E E + N+ + A+ ++++ N
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424
Query: 567 ------QCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGED 620
V + + R + SN E R + A +E +++
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA----------------EEKNISSKYA 1468
Query: 621 DEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQ 680
DE + EAE +LS R+ ++E E E ++ N+++ A +++DLV+
Sbjct: 1469 DERDRAEAEAREKETKALSLARA--LEEALEAKEELERTNKMLKA-----EMEDLVS--S 1519
Query: 681 DDDAAQGV----------------ISASASNLDDFYPAEEDTKQNSN-NTRGNANKTQKD 723
DD + V + L+D A ED K N + + ++D
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1579
Query: 724 TGVNEKAREKFYEAKLQQQQRELKQ----LQEERKKLIDIQEKIQALQTACPDLQLSAAS 779
+AR++ E K +Q QR+L + L++ERK+ + L+ DL+L A S
Sbjct: 1580 L----QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 780 V--GNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELR 837
G K + + + Q E +++ + ++ +NE ++ + L +L
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE-----KKAKSLEADLM 1690
Query: 838 QRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCA 897
Q ++ L A AE R+Q E S N ++ R E +A +
Sbjct: 1691 QLQEDLAA--AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA----QLEEE 1744
Query: 898 LDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHN-SYNGKE-------- 948
L+EE +S+ + + ++ E+ + + + + + S KE
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Query: 949 ---TKNRWKNNCPF------SADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEK--- 996
K+++K+ +E A+ +Q +Q++ + L VE++
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864
Query: 997 -EQWQEQ-------INQLKKQLDFSVSICQTLMQDQQTL 1027
EQ++EQ + QLK+QL+ + Q + +++ L
Sbjct: 1865 AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903
Score = 57.4 bits (137), Expect = 1e-07
Identities = 157/861 (18%), Positives = 330/861 (38%), Gaps = 100/861 (11%)
Query: 49 KKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQA--ELEKLKQR 106
++K E +T +++ E + K H S ++ E++ ELEKLK++
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 107 INFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTSPPNRETI 166
+ D +D Q A A K QL++ + +++ ++ + RE
Sbjct: 1060 LEGDASDFHEQIADLQ--AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1117
Query: 167 GSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDL 226
G S L DL SE R + + + L ++ + ++
Sbjct: 1118 GHI-------SDLQEDL-----DSERAARNKAEKQKRDLGEELEALKTELE--DTLDSTA 1163
Query: 227 VEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQ--QEPMEEIENLKKQHDLLK 284
++ R+ + +T L L E+ +S+ ++++ + Q +E E++E K+ L
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 285 RMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELND 344
+ Q E+ A + +L +A+Q + + A+ S S ELND
Sbjct: 1224 KNKQTLEKENADLAGELRVLG---QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 345 LIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQ--SRKPSASERLPDE---KVELFSK 399
+ + N++ N + +++ L ++V+ S+ E L +E K+ + +K
Sbjct: 1281 KVHKLQNEVESVTGML---NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 400 MRVLQEKKQKM-DKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGES 458
+R L+E++ + D+L E+ ++ + S+ + Q S ++ +++V + G+
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV--EALEEGKK 1395
Query: 459 NSLTSSVPYPTASLVSQNESEN--EGHLNPSEKLQKLNEVRKRLN-ELRELVHYYEQTSD 515
Q E EN + + + KL + + RL EL +LV +
Sbjct: 1396 RF--------------QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441
Query: 516 MMTDAVNENRK------DEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCV 569
++++ + RK +E+ S+Y E + +E + + S + A+
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-E 1500
Query: 570 SNNRDGRTVNSNCE--INNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEE 627
R + + + E ++++ + S + E + + + ED+ + E+
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Query: 628 AEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQG 687
A+ L + +L + D + + N +Q RQL + ++D+ +
Sbjct: 1561 AK------LRLEVNMQALKGQFERDLQARDEQNE-EKRRQLQRQLHEYETELEDERKQRA 1613
Query: 688 VISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELK 747
+ +A+ L+ E ++ R A K + +A+++ QREL+
Sbjct: 1614 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL-----------QAQMKDFQRELE 1662
Query: 748 QLQEERKKLI----DIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHET 803
+ R ++ + ++K ++L+ LQ A+ Q +
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR--------------KQADL 1708
Query: 804 STSKSVFEPEDSSIVDNELWSEMRRHE----MLREELRQRRKQLEALMAEHQRRQGLAET 859
+ E S N L E RR E L EEL + + +EA+ ++ AE
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 860 ASPVAVSLRSDGSENLCTPQQ 880
S + RS +N QQ
Sbjct: 1769 LSNELATERSTAQKNESARQQ 1789
Score = 47.0 bits (110), Expect = 2e-04
Identities = 167/859 (19%), Positives = 317/859 (36%), Gaps = 155/859 (18%)
Query: 1255 EESLESFSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNI 1314
EE LE + + VT K +K + + SK +K ++ N+
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 1315 RYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSETGSD 1374
E + K +N+H + E K+ ++LEK+ + ++ +
Sbjct: 1016 AEEEEKAKNLT---KLKNKHESMISELEVRLKKEEKSRQELEKLKR-----KLEGDASDF 1067
Query: 1375 FSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYA-LQDI---- 1429
L+ I L + E L L E+ N + R L + D+
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 1430 ----VSRHISESHEK--GENVKSVNSGTWIASNSELTPSESLATTDDET--FEKNFERET 1481
+R+ +E ++ GE ++++ + +S T E A + E +K + ET
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187
Query: 1482 H----KISEQNDADNASVLSVSSNFEPFA----------------TDDLGNTVIHLDQAL 1521
++ E +V ++ E F DL + L QA
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 1522 ARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTT------VNNLEETPVIENRSSQQ 1575
+ E+++ K EA+ ++ C DG+ A A N +E + N + +
Sbjct: 1248 QEV-EHKKKKLEAQVQE-LQSKC---SDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 1576 PVS---EVSTIPCPRIDTQQL----DRQIKAI------MKEVIPFLKEHMDEVCSSQLLT 1622
+ +V+++ DTQ+L RQ + ++E L++ +DE ++
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK--Q 1360
Query: 1623 SVRRMVLTLTQQNDESK--------------EFVKFFHKQLGSILQDSLAKFAGR-KLKD 1667
++ R + TL Q +SK E K F K++ ++ Q K A KL+
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Query: 1668 CGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILED 1727
L E+ + L+ DLDN V K++ ++ ++L +
Sbjct: 1421 TKNRLQQELDD----------LVVDLDNQRQLVSNLEKKQ-----------RKFDQLLAE 1459
Query: 1728 HGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINLSK 1787
+ + + DE +D E + + ++ + + + +EE E + + K
Sbjct: 1460 EKNISSKYADE---RDRAEAEAREKETKALSLARALEEALEAKEELERTN------KMLK 1510
Query: 1788 AETQALTNYGSGEDENEDE----------EMEEFEEGPVDVQTSLQANTEATEENEHDEQ 1837
AE + L + +N E +MEE + +++ LQA +A E + Q
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 1838 VLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYLNILEDE---QPLNSAAHKESPPT 1894
L+ F++ ++++ E + Q + Y LEDE + L +AA K+
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRRQLQRQLH-----EYETELEDERKQRALAAAAKKKLEGD 1625
Query: 1895 VD--STQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESG 1952
+ Q + + R ++ L ++K Q E + A + + N+ +A
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA--- 1682
Query: 1953 NISQKSDEEDFVKV-EDLPLKLTIYSEADLRKKMVEEEQKNHLSGEIC------------ 1999
KS E D +++ EDL +ADL K+ + EE + LSG
Sbjct: 1683 ----KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1738
Query: 2000 ---EMQTEELAGNSETLKE 2015
E + EE GN E + +
Sbjct: 1739 AQLEEELEEEQGNMEAMSD 1757
Score = 41.6 bits (96), Expect = 0.008
Identities = 159/813 (19%), Positives = 293/813 (36%), Gaps = 89/813 (10%)
Query: 647 DEHPEDAEFEQKI-NRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEED 705
DE + E +QK N L +QK QL + ++Q+ A+ + A A +
Sbjct: 859 DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM--------- 909
Query: 706 TKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKK----LIDIQE 761
R A K + + ++E EA+L++++ +QLQ ERKK ++D++E
Sbjct: 910 ------RVRLAAKKQELEEILHEM------EARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 762 KIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDN- 820
+++ + A LQL + KK + N ++ S + + E S + N
Sbjct: 958 QLEEEEAARQKLQLEKVT-AEAKIKKLEDEILVMDDQN-NKLSKERKLLEERISDLTTNL 1015
Query: 821 --------ELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGS 872
L +HE + EL R K+ E E ++ + E + SD
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA-------SDFH 1068
Query: 873 ENLCTPQQSRTEKTM--ATWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDN 930
E + Q E M A Q AL DE + + + E E D + +
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 931 FSVCPSNSVNHNSYNGKETKNRWKNNCPFSADE--NYRPLAKTRQQNISMQRQ---ENLR 985
N + E K + D + L R+Q +++ ++ E R
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 986 WVSELSYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSN 1045
E E +++ + + +L +QL+ L +++QTL L G V+
Sbjct: 1189 -SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE-KENADLAGELRVL--G 1244
Query: 1046 VASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLNELMRQQNQHPEKPGG---KERGSSA 1102
A +V +L +L + ++ +R + LN+ + + E G + G +
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 1103 SHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQ 1162
+ TQ + N S+ + + E
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE------EERNSLQDQLDEEMEA 1358
Query: 1163 QQPLAQN-SSGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEK 1221
+Q L ++ S+ + K + +S KK ++E+E+ YE++
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ--YEEKAAAYD 1416
Query: 1222 PFIKTGFSVSVEKS---TSSNRKNQLDTN--GRRRQFDE---ESLESFSSMPDPVDPTTV 1273
KT + E + + QL +N ++R+FD+ E S D D
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 1274 TKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTC-EPCKSRN 1332
K KA + A A ++ + +R + LK+ ++++ + E KS+
Sbjct: 1477 EAREKETKALSLAR-ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 1333 RHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATL 1392
Q EE + E+LE ++ ++ E +AL+ ++
Sbjct: 1536 ALETQMEE-------MKTQLEELEDELQATEDAKLRLEVN-----MQALKGQFERDLQAR 1583
Query: 1393 ISQNESRPHFLIELFHELQLLNTDYLRQRALYA 1425
QNE + L HE + D +QRAL A
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Score = 40.0 bits (92), Expect = 0.023
Identities = 114/613 (18%), Positives = 239/613 (38%), Gaps = 84/613 (13%)
Query: 201 ESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVER-LTHLIDHLKEQEKSYMKFLKK 259
E+ Q ++ ++R + +S+++ L E+ E N+ER ++ L L + +K F
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386
Query: 260 ILARDPQQEPME-EIENLKKQHD-----------LLKRMLQQQEQLRALQGRQAALLALQ 307
+ A + ++ + EIENL +Q++ R+ Q+ + L Q L++
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446
Query: 308 HKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQ 367
K ++ D ++AE +I+S+ +E + R + R+ + A+ R
Sbjct: 1447 EKKQRKF----DQLLAEEK------NISSKYADERD----RAEAEAREKETKALSLARAL 1492
Query: 368 AESLSLTREVSQSRKP---------SASERLPDEKVELFSKMRVLQ----EKKQKMDKLL 414
E+L E+ ++ K S+ + + EL R L+ E K ++++L
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552
Query: 415 GELHTLRDQHLNNSSSSP------QRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYP 468
EL D L + +R + R L ++ L
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE--RK 1610
Query: 469 TASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENR-KD 527
+L + + + EG L E LQ + ++ R +++L Q D + + +D
Sbjct: 1611 QRALAAAAKKKLEGDLKDLE-LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669
Query: 528 E------ETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSN 581
E E E+ E + + ++ + A ++ A+ ++++ GR N+
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR--NAL 1727
Query: 582 CEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSH 641
+ R A I L E E+E + D + + E +S L++
Sbjct: 1728 QDEKRRLEARIAQLE----------EELEEEQGNMEAMSDRVRKATQQAEQLSN-ELATE 1776
Query: 642 RSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYP 701
RS+ + E++ L + KL +++ V A + A + L++
Sbjct: 1777 RSTAQKNESARQQLERQNKEL---RSKLHEMEGAVKSKFKSTIA--ALEAKIAQLEEQVE 1831
Query: 702 AEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYE----------AKLQQQQRELKQLQE 751
E KQ + + +K K+ + + K E A+++Q +R+L++ +E
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1891
Query: 752 ERKKLIDIQEKIQ 764
E +++ + K+Q
Sbjct: 1892 ESQRINANRRKLQ 1904
Score = 38.9 bits (89), Expect = 0.052
Identities = 66/291 (22%), Positives = 117/291 (40%), Gaps = 15/291 (5%)
Query: 1738 EDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEED--EESEGCPVSINLSKAETQALTN 1795
E + K E E + Q KN+ + E + E+E V + K E + + +
Sbjct: 866 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 925
Query: 1796 YGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLE 1855
E E++ ++ + + + E EE E Q LQ + K TAE+K LE
Sbjct: 926 EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE-KVTAEAKIKKLE 984
Query: 1856 REATSKNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLV 1915
E +DQNN K L + E L + +E + T+ N + E+E V
Sbjct: 985 DEILVMDDQNNKLSKERKL-LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--V 1041
Query: 1916 PRVKEVKSAQETPESSLAGSPD-TESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLT 1974
KE KS QE + D ++ + D +A+ + + + K E+L L
Sbjct: 1042 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK----KEEELQAALA 1097
Query: 1975 IYSEADLRKKMVEEEQKNHLSGEICEMQTE---ELAGNSETLKEPETVGAQ 2022
+ ++ +K ++ L G I ++Q + E A ++ K+ +G +
Sbjct: 1098 RLDD-EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1147
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 68.2 bits (165), Expect = 8e-11
Identities = 185/939 (19%), Positives = 370/939 (39%), Gaps = 171/939 (18%)
Query: 218 KASSMREDLVEKNERSANVERL--------THLIDHLKEQEKSYMKF--LKKILARDPQQ 267
+ S + +L E+ E++ N+ +L + L LK++EKS + LK+ L D
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS- 1072
Query: 268 EPMEEIENLKKQHDLLKRMLQQQEQ----------------------LRALQGRQAALL- 304
+ E+I +L+ Q LK L ++E+ +R L+G + L
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132
Query: 305 ------ALQHKAEQAIAVMDDSVVA---ETAGSLSGVSITSELN----EELNDLIQRFHN 351
A ++KAE+ + + + A E +L + EL +E+ L +
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Query: 352 QLRDSQPPAVPDNRRQAESLS-LTREVSQSRKPSAS-----ERLPDEKVELFSKMRVLQE 405
+ R + ++ A+++ LT ++ Q ++ A+ + L E +L ++RVL +
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252
Query: 406 KKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQ------RSTSAPSASVGLAPVVNGESN 459
KQ+++ +L + Q L + S +R+ + + + + G+ G++
Sbjct: 1253 AKQEVEHKKKKLEA-QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 460 SLTSSVPYPTASLVSQNE---SENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDM 516
L V ++ L E E LN S KL++L E R L + + +Q +
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 517 MTDAVNENRKDEETEESEYDSEHENSEP--------VTNIRNP--QVASTWNEVNSHSNA 566
+N D + + ++ S E E + N+ + A+ ++++ N
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 567 ------QCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGED 620
V + + R + SN E R + A +E +++
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA----------------EEKNISSKYA 1475
Query: 621 DEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQ 680
DE + EAE +LS R+ ++E E E ++ N+++ A +++DLV+
Sbjct: 1476 DERDRAEAEAREKETKALSLARA--LEEALEAKEELERTNKMLKA-----EMEDLVS--S 1526
Query: 681 DDDAAQGV----------------ISASASNLDDFYPAEEDTKQNSN-NTRGNANKTQKD 723
DD + V + L+D A ED K N + + ++D
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1586
Query: 724 TGVNEKAREKFYEAKLQQQQRELKQ----LQEERKKLIDIQEKIQALQTACPDLQLSAAS 779
+AR++ E K +Q QR+L + L++ERK+ + L+ DL+L A S
Sbjct: 1587 L----QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 780 V--GNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELR 837
G K + + + Q E +++ + ++ +NE ++ + L +L
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE-----KKAKSLEADLM 1697
Query: 838 QRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCA 897
Q ++ L A AE R+Q E S N ++ R E +A +
Sbjct: 1698 QLQEDLAA--AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA----QLEEE 1751
Query: 898 LDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHN-SYNGKE-------- 948
L+EE +S+ + + ++ E+ + + + + + S KE
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Query: 949 ---TKNRWKNNCPF------SADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEK--- 996
K+++K+ +E A+ +Q +Q++ + L VE++
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871
Query: 997 -EQWQEQ-------INQLKKQLDFSVSICQTLMQDQQTL 1027
EQ++EQ + QLK+QL+ + Q + +++ L
Sbjct: 1872 AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910
Score = 57.4 bits (137), Expect = 1e-07
Identities = 157/861 (18%), Positives = 330/861 (38%), Gaps = 100/861 (11%)
Query: 49 KKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQA--ELEKLKQR 106
++K E +T +++ E + K H S ++ E++ ELEKLK++
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066
Query: 107 INFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTSPPNRETI 166
+ D +D Q A A K QL++ + +++ ++ + RE
Sbjct: 1067 LEGDASDFHEQIADLQ--AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1124
Query: 167 GSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDL 226
G S L DL SE R + + + L ++ + ++
Sbjct: 1125 GHI-------SDLQEDL-----DSERAARNKAEKQKRDLGEELEALKTELE--DTLDSTA 1170
Query: 227 VEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQ--QEPMEEIENLKKQHDLLK 284
++ R+ + +T L L E+ +S+ ++++ + Q +E E++E K+ L
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 285 RMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELND 344
+ Q E+ A + +L +A+Q + + A+ S S ELND
Sbjct: 1231 KNKQTLEKENADLAGELRVLG---QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 345 LIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQ--SRKPSASERLPDE---KVELFSK 399
+ + N++ N + +++ L ++V+ S+ E L +E K+ + +K
Sbjct: 1288 KVHKLQNEVESVTGML---NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 400 MRVLQEKKQKM-DKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGES 458
+R L+E++ + D+L E+ ++ + S+ + Q S ++ +++V + G+
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV--EALEEGKK 1402
Query: 459 NSLTSSVPYPTASLVSQNESEN--EGHLNPSEKLQKLNEVRKRLN-ELRELVHYYEQTSD 515
Q E EN + + + KL + + RL EL +LV +
Sbjct: 1403 RF--------------QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448
Query: 516 MMTDAVNENRK------DEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCV 569
++++ + RK +E+ S+Y E + +E + + S + A+
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-E 1507
Query: 570 SNNRDGRTVNSNCE--INNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEE 627
R + + + E ++++ + S + E + + + ED+ + E+
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Query: 628 AEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQG 687
A+ L + +L + D + + N +Q RQL + ++D+ +
Sbjct: 1568 AK------LRLEVNMQALKGQFERDLQARDEQNE-EKRRQLQRQLHEYETELEDERKQRA 1620
Query: 688 VISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELK 747
+ +A+ L+ E ++ R A K + +A+++ QREL+
Sbjct: 1621 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL-----------QAQMKDFQRELE 1669
Query: 748 QLQEERKKLI----DIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHET 803
+ R ++ + ++K ++L+ LQ A+ Q +
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR--------------KQADL 1715
Query: 804 STSKSVFEPEDSSIVDNELWSEMRRHE----MLREELRQRRKQLEALMAEHQRRQGLAET 859
+ E S N L E RR E L EEL + + +EA+ ++ AE
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 860 ASPVAVSLRSDGSENLCTPQQ 880
S + RS +N QQ
Sbjct: 1776 LSNELATERSTAQKNESARQQ 1796
Score = 47.0 bits (110), Expect = 2e-04
Identities = 167/859 (19%), Positives = 317/859 (36%), Gaps = 155/859 (18%)
Query: 1255 EESLESFSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNI 1314
EE LE + + VT K +K + + SK +K ++ N+
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 1315 RYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSETGSD 1374
E + K +N+H + E K+ ++LEK+ + ++ +
Sbjct: 1023 AEEEEKAKNLT---KLKNKHESMISELEVRLKKEEKSRQELEKLKR-----KLEGDASDF 1074
Query: 1375 FSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYA-LQDI---- 1429
L+ I L + E L L E+ N + R L + D+
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 1430 ----VSRHISESHEK--GENVKSVNSGTWIASNSELTPSESLATTDDET--FEKNFERET 1481
+R+ +E ++ GE ++++ + +S T E A + E +K + ET
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194
Query: 1482 H----KISEQNDADNASVLSVSSNFEPFA----------------TDDLGNTVIHLDQAL 1521
++ E +V ++ E F DL + L QA
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 1522 ARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTT------VNNLEETPVIENRSSQQ 1575
+ E+++ K EA+ ++ C DG+ A A N +E + N + +
Sbjct: 1255 QEV-EHKKKKLEAQVQE-LQSKC---SDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 1576 PVS---EVSTIPCPRIDTQQL----DRQIKAI------MKEVIPFLKEHMDEVCSSQLLT 1622
+ +V+++ DTQ+L RQ + ++E L++ +DE ++
Sbjct: 1310 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK--Q 1367
Query: 1623 SVRRMVLTLTQQNDESK--------------EFVKFFHKQLGSILQDSLAKFAGR-KLKD 1667
++ R + TL Q +SK E K F K++ ++ Q K A KL+
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Query: 1668 CGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILED 1727
L E+ + L+ DLDN V K++ ++ ++L +
Sbjct: 1428 TKNRLQQELDD----------LVVDLDNQRQLVSNLEKKQ-----------RKFDQLLAE 1466
Query: 1728 HGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINLSK 1787
+ + + DE +D E + + ++ + + + +EE E + + K
Sbjct: 1467 EKNISSKYADE---RDRAEAEAREKETKALSLARALEEALEAKEELERTN------KMLK 1517
Query: 1788 AETQALTNYGSGEDENEDE----------EMEEFEEGPVDVQTSLQANTEATEENEHDEQ 1837
AE + L + +N E +MEE + +++ LQA +A E + Q
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577
Query: 1838 VLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYLNILEDE---QPLNSAAHKESPPT 1894
L+ F++ ++++ E + Q + Y LEDE + L +AA K+
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRRQLQRQLH-----EYETELEDERKQRALAAAAKKKLEGD 1632
Query: 1895 VD--STQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESG 1952
+ Q + + R ++ L ++K Q E + A + + N+ +A
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA--- 1689
Query: 1953 NISQKSDEEDFVKV-EDLPLKLTIYSEADLRKKMVEEEQKNHLSGEIC------------ 1999
KS E D +++ EDL +ADL K+ + EE + LSG
Sbjct: 1690 ----KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745
Query: 2000 ---EMQTEELAGNSETLKE 2015
E + EE GN E + +
Sbjct: 1746 AQLEEELEEEQGNMEAMSD 1764
Score = 41.6 bits (96), Expect = 0.008
Identities = 159/813 (19%), Positives = 293/813 (36%), Gaps = 89/813 (10%)
Query: 647 DEHPEDAEFEQKI-NRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEED 705
DE + E +QK N L +QK QL + ++Q+ A+ + A A +
Sbjct: 866 DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM--------- 916
Query: 706 TKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKK----LIDIQE 761
R A K + + ++E EA+L++++ +QLQ ERKK ++D++E
Sbjct: 917 ------RVRLAAKKQELEEILHEM------EARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 762 KIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDN- 820
+++ + A LQL + KK + N ++ S + + E S + N
Sbjct: 965 QLEEEEAARQKLQLEKVT-AEAKIKKLEDEILVMDDQN-NKLSKERKLLEERISDLTTNL 1022
Query: 821 --------ELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGS 872
L +HE + EL R K+ E E ++ + E + SD
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA-------SDFH 1075
Query: 873 ENLCTPQQSRTEKTM--ATWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDN 930
E + Q E M A Q AL DE + + + E E D + +
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 931 FSVCPSNSVNHNSYNGKETKNRWKNNCPFSADE--NYRPLAKTRQQNISMQRQ---ENLR 985
N + E K + D + L R+Q +++ ++ E R
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 986 WVSELSYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSN 1045
E E +++ + + +L +QL+ L +++QTL L G V+
Sbjct: 1196 -SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE-KENADLAGELRVL--G 1251
Query: 1046 VASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLNELMRQQNQHPEKPGG---KERGSSA 1102
A +V +L +L + ++ +R + LN+ + + E G + G +
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 1103 SHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQ 1162
+ TQ + N S+ + + E
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE------EERNSLQDQLDEEMEA 1365
Query: 1163 QQPLAQN-SSGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEK 1221
+Q L ++ S+ + K + +S KK ++E+E+ YE++
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ--YEEKAAAYD 1423
Query: 1222 PFIKTGFSVSVEKS---TSSNRKNQLDTN--GRRRQFDE---ESLESFSSMPDPVDPTTV 1273
KT + E + + QL +N ++R+FD+ E S D D
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 1274 TKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTC-EPCKSRN 1332
K KA + A A ++ + +R + LK+ ++++ + E KS+
Sbjct: 1484 EAREKETKALSLAR-ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 1333 RHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATL 1392
Q EE + E+LE ++ ++ E +AL+ ++
Sbjct: 1543 ALETQMEE-------MKTQLEELEDELQATEDAKLRLEVN-----MQALKGQFERDLQAR 1590
Query: 1393 ISQNESRPHFLIELFHELQLLNTDYLRQRALYA 1425
QNE + L HE + D +QRAL A
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Score = 40.0 bits (92), Expect = 0.023
Identities = 114/613 (18%), Positives = 239/613 (38%), Gaps = 84/613 (13%)
Query: 201 ESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVER-LTHLIDHLKEQEKSYMKFLKK 259
E+ Q ++ ++R + +S+++ L E+ E N+ER ++ L L + +K F
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393
Query: 260 ILARDPQQEPME-EIENLKKQHD-----------LLKRMLQQQEQLRALQGRQAALLALQ 307
+ A + ++ + EIENL +Q++ R+ Q+ + L Q L++
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453
Query: 308 HKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQ 367
K ++ D ++AE +I+S+ +E + R + R+ + A+ R
Sbjct: 1454 EKKQRKF----DQLLAEEK------NISSKYADERD----RAEAEAREKETKALSLARAL 1499
Query: 368 AESLSLTREVSQSRKP---------SASERLPDEKVELFSKMRVLQ----EKKQKMDKLL 414
E+L E+ ++ K S+ + + EL R L+ E K ++++L
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559
Query: 415 GELHTLRDQHLNNSSSSP------QRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYP 468
EL D L + +R + R L ++ L
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE--RK 1617
Query: 469 TASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENR-KD 527
+L + + + EG L E LQ + ++ R +++L Q D + + +D
Sbjct: 1618 QRALAAAAKKKLEGDLKDLE-LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676
Query: 528 E------ETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSN 581
E E E+ E + + ++ + A ++ A+ ++++ GR N+
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR--NAL 1734
Query: 582 CEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSH 641
+ R A I L E E+E + D + + E +S L++
Sbjct: 1735 QDEKRRLEARIAQLE----------EELEEEQGNMEAMSDRVRKATQQAEQLSN-ELATE 1783
Query: 642 RSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYP 701
RS+ + E++ L + KL +++ V A + A + L++
Sbjct: 1784 RSTAQKNESARQQLERQNKEL---RSKLHEMEGAVKSKFKSTIA--ALEAKIAQLEEQVE 1838
Query: 702 AEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYE----------AKLQQQQRELKQLQE 751
E KQ + + +K K+ + + K E A+++Q +R+L++ +E
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1898
Query: 752 ERKKLIDIQEKIQ 764
E +++ + K+Q
Sbjct: 1899 ESQRINANRRKLQ 1911
Score = 38.9 bits (89), Expect = 0.052
Identities = 66/291 (22%), Positives = 117/291 (40%), Gaps = 15/291 (5%)
Query: 1738 EDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEED--EESEGCPVSINLSKAETQALTN 1795
E + K E E + Q KN+ + E + E+E V + K E + + +
Sbjct: 873 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 932
Query: 1796 YGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLE 1855
E E++ ++ + + + E EE E Q LQ + K TAE+K LE
Sbjct: 933 EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE-KVTAEAKIKKLE 991
Query: 1856 REATSKNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLV 1915
E +DQNN K L + E L + +E + T+ N + E+E V
Sbjct: 992 DEILVMDDQNNKLSKERKL-LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--V 1048
Query: 1916 PRVKEVKSAQETPESSLAGSPD-TESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLT 1974
KE KS QE + D ++ + D +A+ + + + K E+L L
Sbjct: 1049 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK----KEEELQAALA 1104
Query: 1975 IYSEADLRKKMVEEEQKNHLSGEICEMQTE---ELAGNSETLKEPETVGAQ 2022
+ ++ +K ++ L G I ++Q + E A ++ K+ +G +
Sbjct: 1105 RLDD-EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1154
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 68.2 bits (165), Expect = 8e-11
Identities = 185/939 (19%), Positives = 370/939 (39%), Gaps = 171/939 (18%)
Query: 218 KASSMREDLVEKNERSANVERL--------THLIDHLKEQEKSYMKF--LKKILARDPQQ 267
+ S + +L E+ E++ N+ +L + L LK++EKS + LK+ L D
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS- 1072
Query: 268 EPMEEIENLKKQHDLLKRMLQQQEQ----------------------LRALQGRQAALL- 304
+ E+I +L+ Q LK L ++E+ +R L+G + L
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132
Query: 305 ------ALQHKAEQAIAVMDDSVVA---ETAGSLSGVSITSELN----EELNDLIQRFHN 351
A ++KAE+ + + + A E +L + EL +E+ L +
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Query: 352 QLRDSQPPAVPDNRRQAESLS-LTREVSQSRKPSAS-----ERLPDEKVELFSKMRVLQE 405
+ R + ++ A+++ LT ++ Q ++ A+ + L E +L ++RVL +
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252
Query: 406 KKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQ------RSTSAPSASVGLAPVVNGESN 459
KQ+++ +L + Q L + S +R+ + + + + G+ G++
Sbjct: 1253 AKQEVEHKKKKLEA-QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 460 SLTSSVPYPTASLVSQNE---SENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDM 516
L V ++ L E E LN S KL++L E R L + + +Q +
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 517 MTDAVNENRKDEETEESEYDSEHENSEP--------VTNIRNP--QVASTWNEVNSHSNA 566
+N D + + ++ S E E + N+ + A+ ++++ N
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 567 ------QCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGED 620
V + + R + SN E R + A +E +++
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA----------------EEKNISSKYA 1475
Query: 621 DEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQ 680
DE + EAE +LS R+ ++E E E ++ N+++ A +++DLV+
Sbjct: 1476 DERDRAEAEAREKETKALSLARA--LEEALEAKEELERTNKMLKA-----EMEDLVS--S 1526
Query: 681 DDDAAQGV----------------ISASASNLDDFYPAEEDTKQNSN-NTRGNANKTQKD 723
DD + V + L+D A ED K N + + ++D
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1586
Query: 724 TGVNEKAREKFYEAKLQQQQRELKQ----LQEERKKLIDIQEKIQALQTACPDLQLSAAS 779
+AR++ E K +Q QR+L + L++ERK+ + L+ DL+L A S
Sbjct: 1587 L----QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 780 V--GNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELR 837
G K + + + Q E +++ + ++ +NE ++ + L +L
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE-----KKAKSLEADLM 1697
Query: 838 QRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCA 897
Q ++ L A AE R+Q E S N ++ R E +A +
Sbjct: 1698 QLQEDLAA--AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA----QLEEE 1751
Query: 898 LDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHN-SYNGKE-------- 948
L+EE +S+ + + ++ E+ + + + + + S KE
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Query: 949 ---TKNRWKNNCPF------SADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEK--- 996
K+++K+ +E A+ +Q +Q++ + L VE++
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871
Query: 997 -EQWQEQ-------INQLKKQLDFSVSICQTLMQDQQTL 1027
EQ++EQ + QLK+QL+ + Q + +++ L
Sbjct: 1872 AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910
Score = 57.4 bits (137), Expect = 1e-07
Identities = 157/861 (18%), Positives = 330/861 (38%), Gaps = 100/861 (11%)
Query: 49 KKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQA--ELEKLKQR 106
++K E +T +++ E + K H S ++ E++ ELEKLK++
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066
Query: 107 INFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTSPPNRETI 166
+ D +D Q A A K QL++ + +++ ++ + RE
Sbjct: 1067 LEGDASDFHEQIADLQ--AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1124
Query: 167 GSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDL 226
G S L DL SE R + + + L ++ + ++
Sbjct: 1125 GHI-------SDLQEDL-----DSERAARNKAEKQKRDLGEELEALKTELE--DTLDSTA 1170
Query: 227 VEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQ--QEPMEEIENLKKQHDLLK 284
++ R+ + +T L L E+ +S+ ++++ + Q +E E++E K+ L
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 285 RMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELND 344
+ Q E+ A + +L +A+Q + + A+ S S ELND
Sbjct: 1231 KNKQTLEKENADLAGELRVLG---QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 345 LIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQ--SRKPSASERLPDE---KVELFSK 399
+ + N++ N + +++ L ++V+ S+ E L +E K+ + +K
Sbjct: 1288 KVHKLQNEVESVTGML---NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 400 MRVLQEKKQKM-DKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGES 458
+R L+E++ + D+L E+ ++ + S+ + Q S ++ +++V + G+
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV--EALEEGKK 1402
Query: 459 NSLTSSVPYPTASLVSQNESEN--EGHLNPSEKLQKLNEVRKRLN-ELRELVHYYEQTSD 515
Q E EN + + + KL + + RL EL +LV +
Sbjct: 1403 RF--------------QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448
Query: 516 MMTDAVNENRK------DEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCV 569
++++ + RK +E+ S+Y E + +E + + S + A+
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-E 1507
Query: 570 SNNRDGRTVNSNCE--INNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEE 627
R + + + E ++++ + S + E + + + ED+ + E+
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Query: 628 AEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQG 687
A+ L + +L + D + + N +Q RQL + ++D+ +
Sbjct: 1568 AK------LRLEVNMQALKGQFERDLQARDEQNE-EKRRQLQRQLHEYETELEDERKQRA 1620
Query: 688 VISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELK 747
+ +A+ L+ E ++ R A K + +A+++ QREL+
Sbjct: 1621 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL-----------QAQMKDFQRELE 1669
Query: 748 QLQEERKKLI----DIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHET 803
+ R ++ + ++K ++L+ LQ A+ Q +
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR--------------KQADL 1715
Query: 804 STSKSVFEPEDSSIVDNELWSEMRRHE----MLREELRQRRKQLEALMAEHQRRQGLAET 859
+ E S N L E RR E L EEL + + +EA+ ++ AE
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 860 ASPVAVSLRSDGSENLCTPQQ 880
S + RS +N QQ
Sbjct: 1776 LSNELATERSTAQKNESARQQ 1796
Score = 47.0 bits (110), Expect = 2e-04
Identities = 167/859 (19%), Positives = 317/859 (36%), Gaps = 155/859 (18%)
Query: 1255 EESLESFSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNI 1314
EE LE + + VT K +K + + SK +K ++ N+
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 1315 RYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSETGSD 1374
E + K +N+H + E K+ ++LEK+ + ++ +
Sbjct: 1023 AEEEEKAKNLT---KLKNKHESMISELEVRLKKEEKSRQELEKLKR-----KLEGDASDF 1074
Query: 1375 FSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYA-LQDI---- 1429
L+ I L + E L L E+ N + R L + D+
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 1430 ----VSRHISESHEK--GENVKSVNSGTWIASNSELTPSESLATTDDET--FEKNFERET 1481
+R+ +E ++ GE ++++ + +S T E A + E +K + ET
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194
Query: 1482 H----KISEQNDADNASVLSVSSNFEPFA----------------TDDLGNTVIHLDQAL 1521
++ E +V ++ E F DL + L QA
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 1522 ARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTT------VNNLEETPVIENRSSQQ 1575
+ E+++ K EA+ ++ C DG+ A A N +E + N + +
Sbjct: 1255 QEV-EHKKKKLEAQVQE-LQSKC---SDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 1576 PVS---EVSTIPCPRIDTQQL----DRQIKAI------MKEVIPFLKEHMDEVCSSQLLT 1622
+ +V+++ DTQ+L RQ + ++E L++ +DE ++
Sbjct: 1310 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK--Q 1367
Query: 1623 SVRRMVLTLTQQNDESK--------------EFVKFFHKQLGSILQDSLAKFAGR-KLKD 1667
++ R + TL Q +SK E K F K++ ++ Q K A KL+
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Query: 1668 CGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILED 1727
L E+ + L+ DLDN V K++ ++ ++L +
Sbjct: 1428 TKNRLQQELDD----------LVVDLDNQRQLVSNLEKKQ-----------RKFDQLLAE 1466
Query: 1728 HGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINLSK 1787
+ + + DE +D E + + ++ + + + +EE E + + K
Sbjct: 1467 EKNISSKYADE---RDRAEAEAREKETKALSLARALEEALEAKEELERTN------KMLK 1517
Query: 1788 AETQALTNYGSGEDENEDE----------EMEEFEEGPVDVQTSLQANTEATEENEHDEQ 1837
AE + L + +N E +MEE + +++ LQA +A E + Q
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577
Query: 1838 VLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYLNILEDE---QPLNSAAHKESPPT 1894
L+ F++ ++++ E + Q + Y LEDE + L +AA K+
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRRQLQRQLH-----EYETELEDERKQRALAAAAKKKLEGD 1632
Query: 1895 VD--STQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESG 1952
+ Q + + R ++ L ++K Q E + A + + N+ +A
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA--- 1689
Query: 1953 NISQKSDEEDFVKV-EDLPLKLTIYSEADLRKKMVEEEQKNHLSGEIC------------ 1999
KS E D +++ EDL +ADL K+ + EE + LSG
Sbjct: 1690 ----KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745
Query: 2000 ---EMQTEELAGNSETLKE 2015
E + EE GN E + +
Sbjct: 1746 AQLEEELEEEQGNMEAMSD 1764
Score = 41.6 bits (96), Expect = 0.008
Identities = 159/813 (19%), Positives = 293/813 (36%), Gaps = 89/813 (10%)
Query: 647 DEHPEDAEFEQKI-NRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEED 705
DE + E +QK N L +QK QL + ++Q+ A+ + A A +
Sbjct: 866 DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM--------- 916
Query: 706 TKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKK----LIDIQE 761
R A K + + ++E EA+L++++ +QLQ ERKK ++D++E
Sbjct: 917 ------RVRLAAKKQELEEILHEM------EARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 762 KIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDN- 820
+++ + A LQL + KK + N ++ S + + E S + N
Sbjct: 965 QLEEEEAARQKLQLEKVT-AEAKIKKLEDEILVMDDQN-NKLSKERKLLEERISDLTTNL 1022
Query: 821 --------ELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGS 872
L +HE + EL R K+ E E ++ + E + SD
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA-------SDFH 1075
Query: 873 ENLCTPQQSRTEKTM--ATWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDN 930
E + Q E M A Q AL DE + + + E E D + +
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 931 FSVCPSNSVNHNSYNGKETKNRWKNNCPFSADE--NYRPLAKTRQQNISMQRQ---ENLR 985
N + E K + D + L R+Q +++ ++ E R
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 986 WVSELSYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSN 1045
E E +++ + + +L +QL+ L +++QTL L G V+
Sbjct: 1196 -SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE-KENADLAGELRVL--G 1251
Query: 1046 VASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLNELMRQQNQHPEKPGG---KERGSSA 1102
A +V +L +L + ++ +R + LN+ + + E G + G +
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 1103 SHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQ 1162
+ TQ + N S+ + + E
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE------EERNSLQDQLDEEMEA 1365
Query: 1163 QQPLAQN-SSGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEK 1221
+Q L ++ S+ + K + +S KK ++E+E+ YE++
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ--YEEKAAAYD 1423
Query: 1222 PFIKTGFSVSVEKS---TSSNRKNQLDTN--GRRRQFDE---ESLESFSSMPDPVDPTTV 1273
KT + E + + QL +N ++R+FD+ E S D D
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 1274 TKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTC-EPCKSRN 1332
K KA + A A ++ + +R + LK+ ++++ + E KS+
Sbjct: 1484 EAREKETKALSLAR-ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 1333 RHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATL 1392
Q EE + E+LE ++ ++ E +AL+ ++
Sbjct: 1543 ALETQMEE-------MKTQLEELEDELQATEDAKLRLEVN-----MQALKGQFERDLQAR 1590
Query: 1393 ISQNESRPHFLIELFHELQLLNTDYLRQRALYA 1425
QNE + L HE + D +QRAL A
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Score = 40.0 bits (92), Expect = 0.023
Identities = 114/613 (18%), Positives = 239/613 (38%), Gaps = 84/613 (13%)
Query: 201 ESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVER-LTHLIDHLKEQEKSYMKFLKK 259
E+ Q ++ ++R + +S+++ L E+ E N+ER ++ L L + +K F
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393
Query: 260 ILARDPQQEPME-EIENLKKQHD-----------LLKRMLQQQEQLRALQGRQAALLALQ 307
+ A + ++ + EIENL +Q++ R+ Q+ + L Q L++
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453
Query: 308 HKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQ 367
K ++ D ++AE +I+S+ +E + R + R+ + A+ R
Sbjct: 1454 EKKQRKF----DQLLAEEK------NISSKYADERD----RAEAEAREKETKALSLARAL 1499
Query: 368 AESLSLTREVSQSRKP---------SASERLPDEKVELFSKMRVLQ----EKKQKMDKLL 414
E+L E+ ++ K S+ + + EL R L+ E K ++++L
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559
Query: 415 GELHTLRDQHLNNSSSSP------QRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYP 468
EL D L + +R + R L ++ L
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE--RK 1617
Query: 469 TASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENR-KD 527
+L + + + EG L E LQ + ++ R +++L Q D + + +D
Sbjct: 1618 QRALAAAAKKKLEGDLKDLE-LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676
Query: 528 E------ETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSN 581
E E E+ E + + ++ + A ++ A+ ++++ GR N+
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR--NAL 1734
Query: 582 CEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSH 641
+ R A I L E E+E + D + + E +S L++
Sbjct: 1735 QDEKRRLEARIAQLE----------EELEEEQGNMEAMSDRVRKATQQAEQLSN-ELATE 1783
Query: 642 RSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYP 701
RS+ + E++ L + KL +++ V A + A + L++
Sbjct: 1784 RSTAQKNESARQQLERQNKEL---RSKLHEMEGAVKSKFKSTIA--ALEAKIAQLEEQVE 1838
Query: 702 AEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYE----------AKLQQQQRELKQLQE 751
E KQ + + +K K+ + + K E A+++Q +R+L++ +E
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1898
Query: 752 ERKKLIDIQEKIQ 764
E +++ + K+Q
Sbjct: 1899 ESQRINANRRKLQ 1911
Score = 38.9 bits (89), Expect = 0.052
Identities = 66/291 (22%), Positives = 117/291 (40%), Gaps = 15/291 (5%)
Query: 1738 EDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEED--EESEGCPVSINLSKAETQALTN 1795
E + K E E + Q KN+ + E + E+E V + K E + + +
Sbjct: 873 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 932
Query: 1796 YGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLE 1855
E E++ ++ + + + E EE E Q LQ + K TAE+K LE
Sbjct: 933 EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE-KVTAEAKIKKLE 991
Query: 1856 REATSKNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLV 1915
E +DQNN K L + E L + +E + T+ N + E+E V
Sbjct: 992 DEILVMDDQNNKLSKERKL-LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--V 1048
Query: 1916 PRVKEVKSAQETPESSLAGSPD-TESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLT 1974
KE KS QE + D ++ + D +A+ + + + K E+L L
Sbjct: 1049 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK----KEEELQAALA 1104
Query: 1975 IYSEADLRKKMVEEEQKNHLSGEICEMQTE---ELAGNSETLKEPETVGAQ 2022
+ ++ +K ++ L G I ++Q + E A ++ K+ +G +
Sbjct: 1105 RLDD-EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1154
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 68.2 bits (165), Expect = 8e-11
Identities = 185/939 (19%), Positives = 370/939 (39%), Gaps = 171/939 (18%)
Query: 218 KASSMREDLVEKNERSANVERL--------THLIDHLKEQEKSYMKF--LKKILARDPQQ 267
+ S + +L E+ E++ N+ +L + L LK++EKS + LK+ L D
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS- 1065
Query: 268 EPMEEIENLKKQHDLLKRMLQQQEQ----------------------LRALQGRQAALL- 304
+ E+I +L+ Q LK L ++E+ +R L+G + L
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125
Query: 305 ------ALQHKAEQAIAVMDDSVVA---ETAGSLSGVSITSELN----EELNDLIQRFHN 351
A ++KAE+ + + + A E +L + EL +E+ L +
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 352 QLRDSQPPAVPDNRRQAESLS-LTREVSQSRKPSAS-----ERLPDEKVELFSKMRVLQE 405
+ R + ++ A+++ LT ++ Q ++ A+ + L E +L ++RVL +
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245
Query: 406 KKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQ------RSTSAPSASVGLAPVVNGESN 459
KQ+++ +L + Q L + S +R+ + + + + G+ G++
Sbjct: 1246 AKQEVEHKKKKLEA-QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 460 SLTSSVPYPTASLVSQNE---SENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDM 516
L V ++ L E E LN S KL++L E R L + + +Q +
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 517 MTDAVNENRKDEETEESEYDSEHENSEP--------VTNIRNP--QVASTWNEVNSHSNA 566
+N D + + ++ S E E + N+ + A+ ++++ N
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424
Query: 567 ------QCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGED 620
V + + R + SN E R + A +E +++
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA----------------EEKNISSKYA 1468
Query: 621 DEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQ 680
DE + EAE +LS R+ ++E E E ++ N+++ A +++DLV+
Sbjct: 1469 DERDRAEAEAREKETKALSLARA--LEEALEAKEELERTNKMLKA-----EMEDLVS--S 1519
Query: 681 DDDAAQGV----------------ISASASNLDDFYPAEEDTKQNSN-NTRGNANKTQKD 723
DD + V + L+D A ED K N + + ++D
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1579
Query: 724 TGVNEKAREKFYEAKLQQQQRELKQ----LQEERKKLIDIQEKIQALQTACPDLQLSAAS 779
+AR++ E K +Q QR+L + L++ERK+ + L+ DL+L A S
Sbjct: 1580 L----QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 780 V--GNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELR 837
G K + + + Q E +++ + ++ +NE ++ + L +L
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE-----KKAKSLEADLM 1690
Query: 838 QRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCA 897
Q ++ L A AE R+Q E S N ++ R E +A +
Sbjct: 1691 QLQEDLAA--AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA----QLEEE 1744
Query: 898 LDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHN-SYNGKE-------- 948
L+EE +S+ + + ++ E+ + + + + + S KE
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Query: 949 ---TKNRWKNNCPF------SADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEK--- 996
K+++K+ +E A+ +Q +Q++ + L VE++
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864
Query: 997 -EQWQEQ-------INQLKKQLDFSVSICQTLMQDQQTL 1027
EQ++EQ + QLK+QL+ + Q + +++ L
Sbjct: 1865 AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903
Score = 57.4 bits (137), Expect = 1e-07
Identities = 157/861 (18%), Positives = 330/861 (38%), Gaps = 100/861 (11%)
Query: 49 KKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQA--ELEKLKQR 106
++K E +T +++ E + K H S ++ E++ ELEKLK++
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1059
Query: 107 INFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTSPPNRETI 166
+ D +D Q A A K QL++ + +++ ++ + RE
Sbjct: 1060 LEGDASDFHEQIADLQ--AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELE 1117
Query: 167 GSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDL 226
G S L DL SE R + + + L ++ + ++
Sbjct: 1118 GHI-------SDLQEDL-----DSERAARNKAEKQKRDLGEELEALKTELE--DTLDSTA 1163
Query: 227 VEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQ--QEPMEEIENLKKQHDLLK 284
++ R+ + +T L L E+ +S+ ++++ + Q +E E++E K+ L
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 285 RMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELND 344
+ Q E+ A + +L +A+Q + + A+ S S ELND
Sbjct: 1224 KNKQTLEKENADLAGELRVLG---QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 345 LIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQ--SRKPSASERLPDE---KVELFSK 399
+ + N++ N + +++ L ++V+ S+ E L +E K+ + +K
Sbjct: 1281 KVHKLQNEVESVTGML---NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 400 MRVLQEKKQKM-DKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGES 458
+R L+E++ + D+L E+ ++ + S+ + Q S ++ +++V + G+
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV--EALEEGKK 1395
Query: 459 NSLTSSVPYPTASLVSQNESEN--EGHLNPSEKLQKLNEVRKRLN-ELRELVHYYEQTSD 515
Q E EN + + + KL + + RL EL +LV +
Sbjct: 1396 RF--------------QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441
Query: 516 MMTDAVNENRK------DEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCV 569
++++ + RK +E+ S+Y E + +E + + S + A+
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-E 1500
Query: 570 SNNRDGRTVNSNCE--INNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEE 627
R + + + E ++++ + S + E + + + ED+ + E+
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Query: 628 AEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQG 687
A+ L + +L + D + + N +Q RQL + ++D+ +
Sbjct: 1561 AK------LRLEVNMQALKGQFERDLQARDEQNE-EKRRQLQRQLHEYETELEDERKQRA 1613
Query: 688 VISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELK 747
+ +A+ L+ E ++ R A K + +A+++ QREL+
Sbjct: 1614 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL-----------QAQMKDFQRELE 1662
Query: 748 QLQEERKKLI----DIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHET 803
+ R ++ + ++K ++L+ LQ A+ Q +
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR--------------KQADL 1708
Query: 804 STSKSVFEPEDSSIVDNELWSEMRRHE----MLREELRQRRKQLEALMAEHQRRQGLAET 859
+ E S N L E RR E L EEL + + +EA+ ++ AE
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 860 ASPVAVSLRSDGSENLCTPQQ 880
S + RS +N QQ
Sbjct: 1769 LSNELATERSTAQKNESARQQ 1789
Score = 47.0 bits (110), Expect = 2e-04
Identities = 167/859 (19%), Positives = 317/859 (36%), Gaps = 155/859 (18%)
Query: 1255 EESLESFSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNI 1314
EE LE + + VT K +K + + SK +K ++ N+
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 1315 RYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSETGSD 1374
E + K +N+H + E K+ ++LEK+ + ++ +
Sbjct: 1016 AEEEEKAKNLT---KLKNKHESMISELEVRLKKEEKSRQELEKLKR-----KLEGDASDF 1067
Query: 1375 FSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYA-LQDI---- 1429
L+ I L + E L L E+ N + R L + D+
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 1430 ----VSRHISESHEK--GENVKSVNSGTWIASNSELTPSESLATTDDET--FEKNFERET 1481
+R+ +E ++ GE ++++ + +S T E A + E +K + ET
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187
Query: 1482 H----KISEQNDADNASVLSVSSNFEPFA----------------TDDLGNTVIHLDQAL 1521
++ E +V ++ E F DL + L QA
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 1522 ARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTT------VNNLEETPVIENRSSQQ 1575
+ E+++ K EA+ ++ C DG+ A A N +E + N + +
Sbjct: 1248 QEV-EHKKKKLEAQVQE-LQSKC---SDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 1576 PVS---EVSTIPCPRIDTQQL----DRQIKAI------MKEVIPFLKEHMDEVCSSQLLT 1622
+ +V+++ DTQ+L RQ + ++E L++ +DE ++
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK--Q 1360
Query: 1623 SVRRMVLTLTQQNDESK--------------EFVKFFHKQLGSILQDSLAKFAGR-KLKD 1667
++ R + TL Q +SK E K F K++ ++ Q K A KL+
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Query: 1668 CGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILED 1727
L E+ + L+ DLDN V K++ ++ ++L +
Sbjct: 1421 TKNRLQQELDD----------LVVDLDNQRQLVSNLEKKQ-----------RKFDQLLAE 1459
Query: 1728 HGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEGCPVSINLSK 1787
+ + + DE +D E + + ++ + + + +EE E + + K
Sbjct: 1460 EKNISSKYADE---RDRAEAEAREKETKALSLARALEEALEAKEELERTN------KMLK 1510
Query: 1788 AETQALTNYGSGEDENEDE----------EMEEFEEGPVDVQTSLQANTEATEENEHDEQ 1837
AE + L + +N E +MEE + +++ LQA +A E + Q
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 1838 VLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYLNILEDE---QPLNSAAHKESPPT 1894
L+ F++ ++++ E + Q + Y LEDE + L +AA K+
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRRQLQRQLH-----EYETELEDERKQRALAAAAKKKLEGD 1625
Query: 1895 VD--STQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESG 1952
+ Q + + R ++ L ++K Q E + A + + N+ +A
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA--- 1682
Query: 1953 NISQKSDEEDFVKV-EDLPLKLTIYSEADLRKKMVEEEQKNHLSGEIC------------ 1999
KS E D +++ EDL +ADL K+ + EE + LSG
Sbjct: 1683 ----KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1738
Query: 2000 ---EMQTEELAGNSETLKE 2015
E + EE GN E + +
Sbjct: 1739 AQLEEELEEEQGNMEAMSD 1757
Score = 41.6 bits (96), Expect = 0.008
Identities = 159/813 (19%), Positives = 293/813 (36%), Gaps = 89/813 (10%)
Query: 647 DEHPEDAEFEQKI-NRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEED 705
DE + E +QK N L +QK QL + ++Q+ A+ + A A +
Sbjct: 859 DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM--------- 909
Query: 706 TKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKK----LIDIQE 761
R A K + + ++E EA+L++++ +QLQ ERKK ++D++E
Sbjct: 910 ------RVRLAAKKQELEEILHEM------EARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 762 KIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDN- 820
+++ + A LQL + KK + N ++ S + + E S + N
Sbjct: 958 QLEEEEAARQKLQLEKVT-AEAKIKKLEDEILVMDDQN-NKLSKERKLLEERISDLTTNL 1015
Query: 821 --------ELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGS 872
L +HE + EL R K+ E E ++ + E + SD
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA-------SDFH 1068
Query: 873 ENLCTPQQSRTEKTM--ATWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDN 930
E + Q E M A Q AL DE + + + E E D + +
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 931 FSVCPSNSVNHNSYNGKETKNRWKNNCPFSADE--NYRPLAKTRQQNISMQRQ---ENLR 985
N + E K + D + L R+Q +++ ++ E R
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 986 WVSELSYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSN 1045
E E +++ + + +L +QL+ L +++QTL L G V+
Sbjct: 1189 -SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE-KENADLAGELRVL--G 1244
Query: 1046 VASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLNELMRQQNQHPEKPGG---KERGSSA 1102
A +V +L +L + ++ +R + LN+ + + E G + G +
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 1103 SHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQ 1162
+ TQ + N S+ + + E
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE------EERNSLQDQLDEEMEA 1358
Query: 1163 QQPLAQN-SSGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEK 1221
+Q L ++ S+ + K + +S KK ++E+E+ YE++
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ--YEEKAAAYD 1416
Query: 1222 PFIKTGFSVSVEKS---TSSNRKNQLDTN--GRRRQFDE---ESLESFSSMPDPVDPTTV 1273
KT + E + + QL +N ++R+FD+ E S D D
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 1274 TKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTC-EPCKSRN 1332
K KA + A A ++ + +R + LK+ ++++ + E KS+
Sbjct: 1477 EAREKETKALSLAR-ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 1333 RHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATL 1392
Q EE + E+LE ++ ++ E +AL+ ++
Sbjct: 1536 ALETQMEE-------MKTQLEELEDELQATEDAKLRLEVN-----MQALKGQFERDLQAR 1583
Query: 1393 ISQNESRPHFLIELFHELQLLNTDYLRQRALYA 1425
QNE + L HE + D +QRAL A
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Score = 40.0 bits (92), Expect = 0.023
Identities = 114/613 (18%), Positives = 239/613 (38%), Gaps = 84/613 (13%)
Query: 201 ESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVER-LTHLIDHLKEQEKSYMKFLKK 259
E+ Q ++ ++R + +S+++ L E+ E N+ER ++ L L + +K F
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386
Query: 260 ILARDPQQEPME-EIENLKKQHD-----------LLKRMLQQQEQLRALQGRQAALLALQ 307
+ A + ++ + EIENL +Q++ R+ Q+ + L Q L++
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446
Query: 308 HKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQ 367
K ++ D ++AE +I+S+ +E + R + R+ + A+ R
Sbjct: 1447 EKKQRKF----DQLLAEEK------NISSKYADERD----RAEAEAREKETKALSLARAL 1492
Query: 368 AESLSLTREVSQSRKP---------SASERLPDEKVELFSKMRVLQ----EKKQKMDKLL 414
E+L E+ ++ K S+ + + EL R L+ E K ++++L
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552
Query: 415 GELHTLRDQHLNNSSSSP------QRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYP 468
EL D L + +R + R L ++ L
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE--RK 1610
Query: 469 TASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENR-KD 527
+L + + + EG L E LQ + ++ R +++L Q D + + +D
Sbjct: 1611 QRALAAAAKKKLEGDLKDLE-LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669
Query: 528 E------ETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSN 581
E E E+ E + + ++ + A ++ A+ ++++ GR N+
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR--NAL 1727
Query: 582 CEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSH 641
+ R A I L E E+E + D + + E +S L++
Sbjct: 1728 QDEKRRLEARIAQLE----------EELEEEQGNMEAMSDRVRKATQQAEQLSN-ELATE 1776
Query: 642 RSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYP 701
RS+ + E++ L + KL +++ V A + A + L++
Sbjct: 1777 RSTAQKNESARQQLERQNKEL---RSKLHEMEGAVKSKFKSTIA--ALEAKIAQLEEQVE 1831
Query: 702 AEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYE----------AKLQQQQRELKQLQE 751
E KQ + + +K K+ + + K E A+++Q +R+L++ +E
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1891
Query: 752 ERKKLIDIQEKIQ 764
E +++ + K+Q
Sbjct: 1892 ESQRINANRRKLQ 1904
Score = 38.9 bits (89), Expect = 0.052
Identities = 66/291 (22%), Positives = 117/291 (40%), Gaps = 15/291 (5%)
Query: 1738 EDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEED--EESEGCPVSINLSKAETQALTN 1795
E + K E E + Q KN+ + E + E+E V + K E + + +
Sbjct: 866 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 925
Query: 1796 YGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLE 1855
E E++ ++ + + + E EE E Q LQ + K TAE+K LE
Sbjct: 926 EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE-KVTAEAKIKKLE 984
Query: 1856 REATSKNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLV 1915
E +DQNN K L + E L + +E + T+ N + E+E V
Sbjct: 985 DEILVMDDQNNKLSKERKL-LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--V 1041
Query: 1916 PRVKEVKSAQETPESSLAGSPD-TESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLT 1974
KE KS QE + D ++ + D +A+ + + + K E+L L
Sbjct: 1042 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK----KEEELQAALA 1097
Query: 1975 IYSEADLRKKMVEEEQKNHLSGEICEMQTE---ELAGNSETLKEPETVGAQ 2022
+ ++ +K ++ L G I ++Q + E A ++ K+ +G +
Sbjct: 1098 RLDD-EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1147
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 66.2 bits (160), Expect = 3e-10
Identities = 127/609 (20%), Positives = 250/609 (41%), Gaps = 91/609 (14%)
Query: 207 SRLVQIRDYITKASSMREDLVE--KN-------ERSANVERLTHLIDHLKEQEKSYMKFL 257
+R++++ D+IT+ + E L E KN E V++L H + +E++ +
Sbjct: 1525 ARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAE 1584
Query: 258 KKILARDPQQEPME-EIENLKKQHDLLKRMLQ-QQEQLRALQGR-----QAALLALQHKA 310
+KIL + Q M+ E+E KK+ + + ++ ++E+L+AL+ R A L L+ KA
Sbjct: 1585 EKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKA 1644
Query: 311 EQAIAVMDDSVVA-----ETAGSLSGVSITSELNEELNDLIQRFHN--------QLRDSQ 357
EQ IA + +++ E S SELN +L + + H + S+
Sbjct: 1645 EQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSE 1704
Query: 358 PPAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGEL 417
VP R A++++ E ++ ++ +EK+ + R L EK++ + ++ E
Sbjct: 1705 TLIVP---RSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQ--RNLTEKEKLLQRVGQEK 1759
Query: 418 HTLRDQHLNNSSSSPQRSVDQRSTSAPS----ASVGLAPVVNGESNSLTSSVPYPTASLV 473
H +R + A + +G E N SL+
Sbjct: 1760 EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNK--------KYSLI 1811
Query: 474 SQNESENEGHLNPSEKLQKL----NEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEE 529
E EG N + Q L ++V+K L E EQ + + ++
Sbjct: 1812 VAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHR 1871
Query: 530 TEESEYDSEHENSEPVTNI--RNPQVA----STWNEVNSH-------SNAQCVSNNRDGR 576
E E S++E + + + RN +T + SH SN + N+ + +
Sbjct: 1872 VEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFK 1931
Query: 577 TVNSNCEINNRSAANIRALNMPPSLDCRYNR-EGEQEIHVAQGEDDEEEEE--EAEEEGV 633
+ E +R D R R E +QE+ + + E D+E EE + E+E +
Sbjct: 1932 LAGAEREKQKLGKEIVRLQK-----DLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDL 1986
Query: 634 SGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVA-MVQDDDAAQGVISAS 692
S+ + + + + + A+ EQ++ M K+ + + Q++ A +++ +
Sbjct: 1987 ELKHNSTLKQLMREFNTQLAQKEQELE--MTIKETINKAQEVEAELLESHQEETNQLLKK 2044
Query: 693 ASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEE 752
+ DD + +T K ARE+ AK++ Q +L++LQ++
Sbjct: 2045 IAEKDD-----------------DLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKK 2087
Query: 753 RKKLIDIQE 761
++ ++ +E
Sbjct: 2088 YQQKLEQEE 2096
Score = 62.8 bits (151), Expect = 3e-09
Identities = 178/921 (19%), Positives = 371/921 (40%), Gaps = 118/921 (12%)
Query: 144 LPMQINTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMES- 202
L Q T K +ET+ + KE+ A ++ N + E+ + +ES
Sbjct: 634 LKQQYQTEMEKLREKCEQEKETL--LKDKEIIFQAHIEEM--NEKTLEKLDVKQTELESL 689
Query: 203 SQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILA 262
S +S +++ R + + S+ +D +K ++ ++ +H ++Q S +K + +
Sbjct: 690 SSELSEVLKARHKLEEELSVLKDQTDKMKQELEA-KMDEQKNHHQQQVDSIIKEHEVSIQ 748
Query: 263 RDPQ--QEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDS 320
R + ++ + ++E L K+ D K + + Q + L+ A + + + +QA A +D
Sbjct: 749 RTEKALKDQINQLELLLKERD--KHLKEHQAHVENLE---ADIKRSEGELQQASAKLDVF 803
Query: 321 VVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQ- 379
++A T E + + + + +L D + E + LT++V++
Sbjct: 804 QSYQSA--------THEQTKAYEEQLAQLQQKLLDLE----------TERILLTKQVAEV 845
Query: 380 -SRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQ 438
++K L K+++ M+ L+++ +M++ + L + + L + + Q Q
Sbjct: 846 EAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKE-QEQTKQ 904
Query: 439 RSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRK 498
+ + + E LT + S+ NE N +K++K V++
Sbjct: 905 ILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEK---VKQ 961
Query: 499 RLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTWN 558
+ E++E + +K +E++ E EN+ + + Q +
Sbjct: 962 KAKEMQETL-----------------KKKLLDQEAKLKKELENTALELSQKEKQFNAKML 1004
Query: 559 EVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSL-DCRYNREGE--QEIHV 615
E+ + +N+ +S+ N +I + + + R LN S+ + + N++ E QEIH
Sbjct: 1005 EM-AQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHE 1063
Query: 616 AQGEDDEEEEEEAEEEGVS-GASLSSHRSSLVDEHPEDAEFEQKINRLMAA-KQKLRQLQ 673
Q ++ E+E E +++ + G + E + + +N L KQK +
Sbjct: 1064 IQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVN 1123
Query: 674 DLVAMVQDDDAAQGVISASASNLDDFYP---------------AEEDTKQNSNNTRGNAN 718
L QD+ + + +L+ AEED ++ S T +
Sbjct: 1124 SLA---QDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELT--SKL 1178
Query: 719 KTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQ-EKIQALQTACPDLQLSA 777
KT + + K+ + L+ + E K+L EE +DI +K +AL A + ++
Sbjct: 1179 KTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINI 1238
Query: 778 AS---------VGNCP---TKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSE 825
+S + +C TK + T TV++ E + E +I + +
Sbjct: 1239 SSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQ 1298
Query: 826 MRRHE----MLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENL---CTP 878
+ E ++ ++ + EAL E +Q A L+ + SEN+
Sbjct: 1299 LEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLM 1358
Query: 879 QQSRTEKTMATWGGSTQCA-LDEE-------GDEDGYLSEGIVRTDEEEEEEQDASSNDN 930
++ EK + S Q L+ + +++ +S + DEE+ E D + +
Sbjct: 1359 KEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLS 1418
Query: 931 FSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSEL 990
F V ++++ + E + W N FS + T+ QN + Q L S+
Sbjct: 1419 FKV---DTLSKEKISALEQVDDWSNK--FSEWKKKAQSRFTQHQNTVKELQIQLELKSKE 1473
Query: 991 SYVEEKEQWQEQINQLKKQLD 1011
+Y ++ EQIN LK++LD
Sbjct: 1474 AYEKD-----EQINLLKEELD 1489
Score = 56.6 bits (135), Expect = 2e-07
Identities = 160/860 (18%), Positives = 338/860 (39%), Gaps = 138/860 (16%)
Query: 209 LVQIRDYITKASSMREDLVEKNERS--ANVERLTHLIDHLKEQEKSYMKFLKKILARDPQ 266
+ Q+R I + ++ E+L E+ E+S A E L + ++ E++ K +
Sbjct: 384 IAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKL---------K 434
Query: 267 QEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETA 326
E E+I+ ++K + +R+ QQE R +Q + ++ +E+ IA + E A
Sbjct: 435 AEMDEQIKTIEKTSEE-ERISLQQELSRV---KQEVVDVMKKSSEEQIAKLQKLHEKELA 490
Query: 327 GSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQSRKPSAS 386
EL ++L + F Q++ V + Q+E L +++E Q
Sbjct: 491 RK------EQELTKKLQTREREFQEQMK------VALEKSQSEYLKISQEKEQQ------ 532
Query: 387 ERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSA 446
E L E++EL K +L E + K+ L E T R + L SS ++S+ + +
Sbjct: 533 ESLALEELEL-QKKAILTESENKLRDLQQEAETYRTRILELESSL-EKSLQENKNQSKDL 590
Query: 447 SVGLAPVVNGESNSLTSSVPYPTASLVSQNESEN-----------EGHLNPSEKL-QKLN 494
+V L N + +T V L S ++ + + EKL +K
Sbjct: 591 AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCE 650
Query: 495 EVRKRLNELRELVH--YYEQTSDMMTDAVNENRKDEETEESEYD----SEHENSEPVTNI 548
+ ++ L + +E++ + E+ ++ + ++ + + E+ SE + H+ E ++ +
Sbjct: 651 QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL 710
Query: 549 RNP------QVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLD 602
++ ++ + +E +H Q S ++ E + N L +
Sbjct: 711 KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKE--- 767
Query: 603 CRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRL 662
R E + HV E D + E ++ + A L +S H + +E+++ +L
Sbjct: 768 -RDKHLKEHQAHVENLEADIKRSEGELQQ--ASAKLDVFQSYQSATHEQTKAYEEQLAQL 824
Query: 663 MAAKQKLRQLQ-DLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQ 721
+QKL L+ + + + + + + LD +D Q + N+ Q
Sbjct: 825 ---QQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLE--KQNSEMEQ 879
Query: 722 KDTGVNEKAREKFYEAKLQ---QQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAA 778
K K+ + YE+KL+ ++Q + KQ+ E++ +I + Q + +LSA
Sbjct: 880 K-----VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAK 934
Query: 779 SVG-NCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRH-EMLREEL 836
+ ++Y + + +K + E ++D E +++++ E EL
Sbjct: 935 EDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQE--AKLKKELENTALEL 992
Query: 837 RQRRKQLEALMAEHQRRQ--GLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGST 894
Q+ KQ A M E + G+++ S + + + + E+L + ++ W
Sbjct: 993 SQKEKQFNAKMLEMAQANSAGISDAVSRLETN-QKEQIESLTEVHRRELNDVISIW---- 1047
Query: 895 QCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWK 954
+ L+++ +E + E ++ E+E+E + C +N
Sbjct: 1048 EKKLNQQAEELQEIHE--IQLQEKEQEVAELKQKILLFGCEKEEMN-------------- 1091
Query: 955 NNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKKQLDFSV 1014
+ + W+ E E + +N+L++QL
Sbjct: 1092 ---------------------------KEITWLKE-----EGVKQDTTLNELQEQLKQKS 1119
Query: 1015 SICQTLMQDQQTLSCLLQTL 1034
+ +L QD+ L L+ L
Sbjct: 1120 AHVNSLAQDETKLKAHLEKL 1139
Score = 48.5 bits (114), Expect = 7e-05
Identities = 156/820 (19%), Positives = 324/820 (39%), Gaps = 169/820 (20%)
Query: 85 HSRYMSQMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFL 144
H ++Q +A LEKL+ +N +S+ ++ + K E+++ + L
Sbjct: 1121 HVNSLAQDETKLKAHLEKLEVDLN------KSLKENTFLQEQLVELKMLAEEDKRKVSEL 1174
Query: 145 PMQINTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQN----CQVSE---EDGRGE 197
++ T + S + ++ S + K L LS +L C+ +E E E
Sbjct: 1175 TSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNE 1234
Query: 198 ----PAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVE-RLTHLIDHLKEQEKS 252
+ +++ I+SR+ + TK ++E L+ K + +E +L L + S
Sbjct: 1235 LINISSSKTNAILSRISHCQHRTTK---VKEALLIKTCTVSELEAQLRQLTEEQNTLNIS 1291
Query: 253 YMKFLKKILARDPQQEPME-EIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAE 311
+ + ++ ++ Q + M+ +IE+L + + L++ Q+Q A +++ + L+ +
Sbjct: 1292 FQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ--AASEKESCITQLKKELS 1349
Query: 312 Q---AIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRR-- 366
+ A+ +M + + + V I+S L+++L DL + N + S+ A + R
Sbjct: 1350 ENINAVTLMKEELKEKK------VEISS-LSKQLTDLNVQLQNSISLSEKEAAISSLRKQ 1402
Query: 367 ----------QAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGE 416
Q + LS + K SA E++ D+ FS+ KK+ +
Sbjct: 1403 YDEEKCELLDQVQDLSFKVDTLSKEKISALEQV-DDWSNKFSEW-----KKKAQSRFTQH 1456
Query: 417 LHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLA----PVVNGESNSLTSSVPYPTASL 472
+T+++ + S + + + + GE S + ++L
Sbjct: 1457 QNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL 1516
Query: 473 VSQNESEN------EGHLNPSE-KLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENR 525
++ +S+ E H+ +++ LNEV K N+ +++ H + V + +
Sbjct: 1517 ETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEH---------KELVQKLQ 1567
Query: 526 KDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNS------HSNAQCVSNNRDGRTVN 579
+E E + + E E + + N QV S E+ + H N S + + +
Sbjct: 1568 HFQELGEEKDNRVKEAEEKILTLEN-QVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
Query: 580 SNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGE--DDEEEEEEAEEEGVSGAS 637
E + SAA + L R+ EQ+I + + EE+EE ++G
Sbjct: 1627 DRLE--SESAAKLAELK----------RKAEQKIAAIKKQLLSQMEEKEEQYKKGTE--- 1671
Query: 638 LSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLD 697
SH S L +L ++++ L++ + V+ + ++ SA N+
Sbjct: 1672 --SHLSELN-------------TKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVA 1716
Query: 698 DFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLI 757
+ T+Q +++G KT YE K+ QR L E++KL+
Sbjct: 1717 AY------TEQEEADSQGCVQKT--------------YEEKISVLQRNLT----EKEKLL 1752
Query: 758 DI--QEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDS 815
QEK + + S+ C ++ + + QHE D
Sbjct: 1753 QRVGQEKEETV---------SSHFEMRCQYQERLIKLEHAEA-KQHE-----------DQ 1791
Query: 816 SIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQG 855
S++ + L+EEL ++ K+ ++A+H ++G
Sbjct: 1792 SMIGH-----------LQEELEEKNKKYSLIVAQHVEKEG 1820
Score = 38.9 bits (89), Expect = 0.052
Identities = 68/335 (20%), Positives = 132/335 (39%), Gaps = 90/335 (26%)
Query: 1719 KEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTS----EVYDGPKNV----------- 1763
++AK+ L++ E D ++KD+ +V QTQ S + +GP NV
Sbjct: 200 QQAKKHLQE------EFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEP 253
Query: 1764 RSDISDQEEDEESEGCPV-----------------------------SINLSKAETQALT 1794
++++ +EE+ ES+G PV +I K + LT
Sbjct: 254 QAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLT 313
Query: 1795 NYGSGEDENEDEEMEEFEE-------GPVDVQTSLQANTEATEENEHDEQVL----QRDF 1843
+ E DE ++E E+ + T L+ E+ E D+ ++ +R
Sbjct: 314 SEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQM 373
Query: 1844 KKTAESKNVPLE------REATSKNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDS 1897
+T E K + ++ T++ ++ + E ++ AA +E + +
Sbjct: 374 HETLEMKEEEIAQLRSRIKQMTTQGEE-----------LREQKEKSERAAFEELEKALST 422
Query: 1898 TQQPNPLPLRL-PEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQ 1956
Q+ +L EM+ +++K+ ++T E S V + E ++ +
Sbjct: 423 AQKTEEARRKLKAEMD------EQIKTIEKTSEEERISLQQELSRV-----KQEVVDVMK 471
Query: 1957 KSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQK 1991
KS EE K++ L K E +L KK+ E++
Sbjct: 472 KSSEEQIAKLQKLHEKELARKEQELTKKLQTRERE 506
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 65.9 bits (159), Expect = 4e-10
Identities = 169/907 (18%), Positives = 352/907 (38%), Gaps = 160/907 (17%)
Query: 200 MESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKK 259
+ES++ + + + SS++E L + R+ + +T L +H +E+++ K +K
Sbjct: 487 LESNKPAGDVDMSLSLLQEISSLQEKL--EVTRTDHQREITSLKEHFGAREETHQKEIKA 544
Query: 260 ILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLAL-QHKAEQAIA--- 315
+ E L K+++ LK L+ + + ++AL + K E AIA
Sbjct: 545 LYTAT---------EKLSKENESLKSKLEHANK------ENSDVIALWKSKLETAIASHQ 589
Query: 316 -VMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLT 374
M++ V+ + G + + +EL ++ + + +++ + Q N++ +E +
Sbjct: 590 QAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQ------NQQDSERAAHA 643
Query: 375 REVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQR 434
+E+ R M+V++EK+ ++ + +L DQHL + +
Sbjct: 644 KEMEALRA---------------KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 688
Query: 435 SVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLN 494
V V+ + N T + T+ L + EKL L+
Sbjct: 689 ------LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA-----------TEEKLLDLD 731
Query: 495 EVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVA 554
+RK +E + + Q +A + K E E ++ S ++I
Sbjct: 732 ALRKASSEGKSEMKKLRQ----QLEAAEKQIKHLEIE------KNAESSKASSITRELQG 781
Query: 555 STWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIH 614
N N VS ++ T+ +I L ++ E+ +
Sbjct: 782 RELKLTNLQENLSEVSQVKE--TLEKELQI----------------LKEKFAEASEEAVS 823
Query: 615 VAQG--EDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKL-RQ 671
V + E + ++ E+ + + L R +L D + E +++ +L+ AK+KL
Sbjct: 824 VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEND 883
Query: 672 LQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAR 731
+ +++ M D+ S+ + ++D +E ++ + K ++ +K+
Sbjct: 884 IAEIMKMSGDN-------SSQLTKMNDELRLKE---RDVEELQLKLTKANENASFLQKSI 933
Query: 732 EKFYEAKLQQQQRELKQLQEERK----KLIDIQEKIQALQTACPDLQLSAASVGNCPTKK 787
E Q QQ K+ +EE+K KL D+++K++ C +L+ +
Sbjct: 934 EDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELK-----------AR 982
Query: 788 YMPAVTSTPTVNQHE---TSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLE 844
Y A + T T +HE + K++ + ED +L + L +EL + RKQ
Sbjct: 983 YERATSETKT--KHEEILQNLQKTLLDTED------KLKGAREENSGLLQELEELRKQ-- 1032
Query: 845 ALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDE 904
A+ + AE A + + + +E L + + ++ T L E D
Sbjct: 1033 ---ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK----------QTNAKLQNELDT 1079
Query: 905 DGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADEN 964
L E ++ EE + ++ + +N + K+ + +EN
Sbjct: 1080 ---LKENNLKNVEELNKSKELLTVENQKM---EEFRKEIETLKQAAAQKSQQLSALQEEN 1133
Query: 965 YR---PLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQI---NQLKKQLDFSVSICQ 1018
+ L ++R + S Q+ E R V +E K++ + I ++ K L S+SI
Sbjct: 1134 VKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITS 1193
Query: 1019 TLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQM 1078
L+ ++ L+ L + N ++ +H ++ L +L + V+ L+
Sbjct: 1194 ALLTEK---DAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKL---ELKVKNLELQ 1247
Query: 1079 LNELMRQ 1085
L E RQ
Sbjct: 1248 LKENKRQ 1254
Score = 37.4 bits (85), Expect = 0.15
Identities = 117/658 (17%), Positives = 238/658 (36%), Gaps = 115/658 (17%)
Query: 1230 VSVEKSTSSNRKNQLDTNGRRRQFD----EESLESFSSMPDPVDPTTVTKTFKTRKASAQ 1285
+ +EK+ S++ + + + R+ +E+L S + + ++ K +AS +
Sbjct: 761 LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEE 820
Query: 1286 A---SLASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPV 1342
A + ++ K K+ L S ++ +R A M + K R + + E+ +
Sbjct: 821 AVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEA-----KFREKDERE-EQLI 874
Query: 1343 QAKVFSRKNHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTI------YSEVATLISQN 1396
+AK E+LE N EI +G + S + D + E+ +++
Sbjct: 875 KAK-------EKLE-----NDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKA 922
Query: 1397 ESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASN 1456
FL + ++ + +A + Q+ +H E E + + + N
Sbjct: 923 NENASFLQKSIEDMTV--------KAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN 974
Query: 1457 S--ELTPSESLATTDDETFEKNFERETHKISEQND-------ADNASVLSVSSNFEPFAT 1507
EL AT++ +T + + K + +N+ +L A
Sbjct: 975 QCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQA- 1033
Query: 1508 DDLGNTVIHLDQALARMREYERMKTEA--------ESNSNMRCTCRIIEDGDGAGAGTTV 1559
D + A+ M + + KTE ++N+ ++ +++ + +
Sbjct: 1034 -DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNV-EEL 1091
Query: 1560 NNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKE---HMDEVC 1616
N +E +EN+ ++ E+ T+ + Q +Q+ A+ +E + +E DEV
Sbjct: 1092 NKSKELLTVENQKMEEFRKEIETL---KQAAAQKSQQLSALQEENVKLAEELGRSRDEVT 1148
Query: 1617 SSQLLTSVRRMVLT-LTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVE 1675
S Q L R ++ L + +F+K ++ S+ + A KD + L
Sbjct: 1149 SHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRN 1208
Query: 1676 ISEVLFNELAFFK----LMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSP 1731
VL E A K ++Q L+++ + ++ + K ++ KE KR L
Sbjct: 1209 EVTVLRGENASAKSLHSVVQTLESDKVKLELKVKN-------LELQLKENKRQLSSSSGN 1261
Query: 1732 AGEIDDEDKDKDETET------------------VKQTQTSEV-----------YDGPKN 1762
DED+ E++ +K SE YD
Sbjct: 1262 TDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQ 1321
Query: 1763 VRS---------DISDQEEDEESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEF 1811
+ DI D + ++E CP +S+ + + GE+ E E F
Sbjct: 1322 EKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMF 1379
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 65.9 bits (159), Expect = 4e-10
Identities = 169/907 (18%), Positives = 352/907 (38%), Gaps = 160/907 (17%)
Query: 200 MESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKK 259
+ES++ + + + SS++E L + R+ + +T L +H +E+++ K +K
Sbjct: 522 LESNKPAGDVDMSLSLLQEISSLQEKL--EVTRTDHQREITSLKEHFGAREETHQKEIKA 579
Query: 260 ILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLAL-QHKAEQAIA--- 315
+ E L K+++ LK L+ + + ++AL + K E AIA
Sbjct: 580 LYTAT---------EKLSKENESLKSKLEHANK------ENSDVIALWKSKLETAIASHQ 624
Query: 316 -VMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLT 374
M++ V+ + G + + +EL ++ + + +++ + Q N++ +E +
Sbjct: 625 QAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQ------NQQDSERAAHA 678
Query: 375 REVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQR 434
+E+ R M+V++EK+ ++ + +L DQHL + +
Sbjct: 679 KEMEALRA---------------KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 723
Query: 435 SVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLN 494
V V+ + N T + T+ L + EKL L+
Sbjct: 724 ------LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA-----------TEEKLLDLD 766
Query: 495 EVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVA 554
+RK +E + + Q +A + K E E ++ S ++I
Sbjct: 767 ALRKASSEGKSEMKKLRQ----QLEAAEKQIKHLEIE------KNAESSKASSITRELQG 816
Query: 555 STWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIH 614
N N VS ++ T+ +I L ++ E+ +
Sbjct: 817 RELKLTNLQENLSEVSQVKE--TLEKELQI----------------LKEKFAEASEEAVS 858
Query: 615 VAQG--EDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKL-RQ 671
V + E + ++ E+ + + L R +L D + E +++ +L+ AK+KL
Sbjct: 859 VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEND 918
Query: 672 LQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAR 731
+ +++ M D+ S+ + ++D +E ++ + K ++ +K+
Sbjct: 919 IAEIMKMSGDN-------SSQLTKMNDELRLKE---RDVEELQLKLTKANENASFLQKSI 968
Query: 732 EKFYEAKLQQQQRELKQLQEERK----KLIDIQEKIQALQTACPDLQLSAASVGNCPTKK 787
E Q QQ K+ +EE+K KL D+++K++ C +L+ +
Sbjct: 969 EDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELK-----------AR 1017
Query: 788 YMPAVTSTPTVNQHE---TSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLE 844
Y A + T T +HE + K++ + ED +L + L +EL + RKQ
Sbjct: 1018 YERATSETKT--KHEEILQNLQKTLLDTED------KLKGAREENSGLLQELEELRKQ-- 1067
Query: 845 ALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDE 904
A+ + AE A + + + +E L + + ++ T L E D
Sbjct: 1068 ---ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK----------QTNAKLQNELDT 1114
Query: 905 DGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADEN 964
L E ++ EE + ++ + +N + K+ + +EN
Sbjct: 1115 ---LKENNLKNVEELNKSKELLTVENQKM---EEFRKEIETLKQAAAQKSQQLSALQEEN 1168
Query: 965 YR---PLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQI---NQLKKQLDFSVSICQ 1018
+ L ++R + S Q+ E R V +E K++ + I ++ K L S+SI
Sbjct: 1169 VKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITS 1228
Query: 1019 TLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQM 1078
L+ ++ L+ L + N ++ +H ++ L +L + V+ L+
Sbjct: 1229 ALLTEK---DAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKL---ELKVKNLELQ 1282
Query: 1079 LNELMRQ 1085
L E RQ
Sbjct: 1283 LKENKRQ 1289
Score = 37.4 bits (85), Expect = 0.15
Identities = 117/658 (17%), Positives = 238/658 (36%), Gaps = 115/658 (17%)
Query: 1230 VSVEKSTSSNRKNQLDTNGRRRQFD----EESLESFSSMPDPVDPTTVTKTFKTRKASAQ 1285
+ +EK+ S++ + + + R+ +E+L S + + ++ K +AS +
Sbjct: 796 LEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEE 855
Query: 1286 A---SLASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPV 1342
A + ++ K K+ L S ++ +R A M + K R + + E+ +
Sbjct: 856 AVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEA-----KFREKDERE-EQLI 909
Query: 1343 QAKVFSRKNHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTI------YSEVATLISQN 1396
+AK E+LE N EI +G + S + D + E+ +++
Sbjct: 910 KAK-------EKLE-----NDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKA 957
Query: 1397 ESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASN 1456
FL + ++ + +A + Q+ +H E E + + + N
Sbjct: 958 NENASFLQKSIEDMTV--------KAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN 1009
Query: 1457 S--ELTPSESLATTDDETFEKNFERETHKISEQND-------ADNASVLSVSSNFEPFAT 1507
EL AT++ +T + + K + +N+ +L A
Sbjct: 1010 QCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQA- 1068
Query: 1508 DDLGNTVIHLDQALARMREYERMKTEA--------ESNSNMRCTCRIIEDGDGAGAGTTV 1559
D + A+ M + + KTE ++N+ ++ +++ + +
Sbjct: 1069 -DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNV-EEL 1126
Query: 1560 NNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKE---HMDEVC 1616
N +E +EN+ ++ E+ T+ + Q +Q+ A+ +E + +E DEV
Sbjct: 1127 NKSKELLTVENQKMEEFRKEIETL---KQAAAQKSQQLSALQEENVKLAEELGRSRDEVT 1183
Query: 1617 SSQLLTSVRRMVLT-LTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVE 1675
S Q L R ++ L + +F+K ++ S+ + A KD + L
Sbjct: 1184 SHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRN 1243
Query: 1676 ISEVLFNELAFFK----LMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSP 1731
VL E A K ++Q L+++ + ++ + K ++ KE KR L
Sbjct: 1244 EVTVLRGENASAKSLHSVVQTLESDKVKLELKVKN-------LELQLKENKRQLSSSSGN 1296
Query: 1732 AGEIDDEDKDKDETET------------------VKQTQTSEV-----------YDGPKN 1762
DED+ E++ +K SE YD
Sbjct: 1297 TDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQ 1356
Query: 1763 VRS---------DISDQEEDEESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEF 1811
+ DI D + ++E CP +S+ + + GE+ E E F
Sbjct: 1357 EKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMF 1414
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 64.3 bits (155), Expect = 1e-09
Identities = 183/977 (18%), Positives = 362/977 (37%), Gaps = 158/977 (16%)
Query: 247 KEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLAL 306
KE KS MK + L R +Q + ++ K + L + +++ L G L
Sbjct: 2109 KESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNK 2168
Query: 307 QHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRR 366
+ K Q + DS V + A +S + + + D +++ + D+ + R
Sbjct: 2169 KDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL 2228
Query: 367 QAESLSLTREVSQSRKPSASE------RLPDEKVELFSKMRVLQEKKQKM-DKLLGELHT 419
+ ++ S+ ++ + E RL +K SK + + +QK+ D L GE
Sbjct: 2229 KEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKE 2288
Query: 420 LRDQ-----HLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYP--TASL 472
L Q HL +SS + ++ S L SNSL +
Sbjct: 2289 LLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL-------SNSLEKCKEQKGNLEGI 2341
Query: 473 VSQNESENEGHLNPSEKLQK-LNEVRKRLNELRELVHYYEQT--------SDMMTDAVNE 523
+ Q E++ + E+L+ L R+ + L E ++ EQ + + A+ E
Sbjct: 2342 IRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAE 2401
Query: 524 NRKDEETEESEYD---SEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNS 580
R+ + E E + S+ E V N + N++ N +
Sbjct: 2402 LRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKEN------IQQ 2455
Query: 581 NCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAE----EEGVSGA 636
++++ + N + Y + E+ + + +D +E AE +E + G
Sbjct: 2456 KAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRG- 2514
Query: 637 SLSSHRSSLVDEHPE-DAE---FEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISAS 692
L SH L E+ + DAE + + +N+++ K +Q Q L +Q + + +
Sbjct: 2515 -LRSHMDDLNSENAKLDAELIQYREDLNQVITIKDS-QQKQLLEVQLQQNKELENKYAKL 2572
Query: 693 ASNLDDFYPAEEDTKQNSNNTRGNANKTQKD---------------TGVNEKAREKFYEA 737
L + A ED +++ N + K+ T + E+ Y A
Sbjct: 2573 EEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHA 2632
Query: 738 KLQQQQRELKQLQ----EERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTK--KYMPA 791
+L+ ++ E+ +L +K++ +++E++ +Q +A VG K K +
Sbjct: 2633 QLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKE------AAKKVGEIEDKLKKELKH 2686
Query: 792 VTSTPTVNQHETSTSKSVFEPEDSSIVDNE-----------------------LWSEMRR 828
+ + ++ET T++ +V+ E + S
Sbjct: 2687 LHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNS 2746
Query: 829 HEMLREELRQRRKQLEALMAE--HQRRQGLAETA-----SPVAVSLRSDGSENLCTPQQ- 880
+ EEL + +++ +A + E + QGL S A S+ S +L ++
Sbjct: 2747 RDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKL 2806
Query: 881 -----SRTEKTMATWGG---------STQCALDEEGDEDGYLSEGIVRTDEEEEEEQDAS 926
S+ E+ + S A+ +E +L + + + EE +Q ++
Sbjct: 2807 NQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSA 2866
Query: 927 SNDNFSVCPSNSV--------NHNSYNGKETKNRWKNNCPFSAD-----------ENYRP 967
+ + S S+ N KE KN + + + + Y+
Sbjct: 2867 AQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQD 2926
Query: 968 LAKTRQQNISMQRQENLRWVSELSYVE-EKEQWQEQINQLKKQL-------DFSVSICQT 1019
K Q RQENL W EL + EK W+ ++K+Q D +S Q
Sbjct: 2927 KTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQN 2986
Query: 1020 LMQDQQTLSCLLQTL-LTGPYSVMPSNVASP--------QVHFIMHQLNQCYTQLTWQQN 1070
L+++ ++ S Q L + P ASP + + QLN ++ ++
Sbjct: 2987 LIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL 3046
Query: 1071 NVQRLKQMLNELMRQQN 1087
+Q+L ++L+ ++N
Sbjct: 3047 RIQQLNSNFSQLLEEKN 3063
Score = 62.4 bits (150), Expect = 4e-09
Identities = 211/1074 (19%), Positives = 404/1074 (37%), Gaps = 160/1074 (14%)
Query: 90 SQMSVPEQAEL--EKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQ 147
S +V +AE+ E L+Q++ S L + + + ++ +S+ + ++L Q
Sbjct: 1355 SLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQ 1414
Query: 148 INTNKSK--DASTSPPNRETIGSAQCKELFASALSND---------LLQNCQVSEEDGRG 196
++ ++ T +E + A +L A +D L + Q EE G
Sbjct: 1415 LSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEE 1474
Query: 197 EPAMESSQ--IVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYM 254
A + Q + + L+ ++ + + S++E+L + +ERLT + ++ Q +
Sbjct: 1475 SRAKQQIQRKLQAALISRKEALKENKSLQEEL---SLARGTIERLTKSLADVESQVSAQN 1531
Query: 255 KFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAI 314
K +L R + EE + L + D + +L+ Q + + + AL L E+ +
Sbjct: 1532 KEKDTVLGRLALLQ--EERDKLITEMD--RSLLENQSLSSSCESLKLALEGLTEDKEKLV 1587
Query: 315 AVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLT 374
++ ++ A S EL +E L+Q + N +++
Sbjct: 1588 KEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAE----------------- 1630
Query: 375 REVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRD---QHLNNSSSS 431
R E + EK EL+ K+R + K++ +K L E + + + + S
Sbjct: 1631 ------RIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKS 1684
Query: 432 PQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQ 491
Q+ + + + P + ++ AS+ + E + S+K Q
Sbjct: 1685 KQQKILELEEENDRLRAEVHP-AGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQ 1743
Query: 492 KLNEVRKRLN-ELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRN 550
L + L+ E+++L H E + + D +T +E ++ E T ++
Sbjct: 1744 SLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGE--TEEQD 1801
Query: 551 PQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINN------RSAANIRALNMPPSLDCR 604
ST + + +N + +S+ EINN + I L +
Sbjct: 1802 SLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKE 1861
Query: 605 YNR--EGEQEIHVAQGEDDEEEEEEAEEEGVSGASLS---SHRSSLVDEHPEDAEFEQK- 658
+++ E E+ ++Q + E + +EE L+ S V + E AE E+
Sbjct: 1862 FSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDD 1921
Query: 659 -INRLMAAKQKLR-QLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGN 716
RLM +L + + V D ++ + NL E+ KQ +
Sbjct: 1922 LEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTK 1981
Query: 717 ANK------------TQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQ 764
QK+ G K+ K + L+++Q+E+KQLQ K I QEKI
Sbjct: 1982 VESEIRKEYLEKIQGAQKEPG--NKSHAKELQELLKEKQQEVKQLQ---KDCIRYQEKIS 2036
Query: 765 ALQTACPDLQL--SAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSS----IV 818
AL+ L+ + + TK+ + Q E ++ K + + S +
Sbjct: 2037 ALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLA 2096
Query: 819 DN-----ELWS----------------EMRRHEMLREELRQRRKQLEALMAEHQRRQGLA 857
DN EL S E R + + L++++ E L A + + L
Sbjct: 2097 DNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLE 2156
Query: 858 ETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRTDE 917
ET + V+L E Q + T+ T+ + D D + DE
Sbjct: 2157 ETIGEIQVTLNKKDKE--VQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVI-------DE 2207
Query: 918 EEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWK-NNCPFSADENYRPLAKTRQQNI 976
++ E+ S ++ KE + R K +NC D+ RQ +I
Sbjct: 2208 AKKWERKFS---------------DAIQSKEEEIRLKEDNCSVLKDQ-------LRQMSI 2245
Query: 977 SMQRQENLRWVSELSYVEEKEQWQEQINQLKKQLDFSVSICQTLM-QDQQTLSCLLQTLL 1035
M+ + +S +E +Q E Q + QL +C TL ++++ LS L +T
Sbjct: 2246 HMEELK-----INISRLEHDKQIWESKAQTEVQL--QQKVCDTLQGENKELLSQLEET-- 2296
Query: 1036 TGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQM---LNELMRQQ 1086
Y + +A + +L QLT N++++ K+ L ++RQQ
Sbjct: 2297 RHLYHSSQNELAK-----LESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQ 2345
Score = 56.2 bits (134), Expect = 3e-07
Identities = 334/1911 (17%), Positives = 717/1911 (37%), Gaps = 289/1911 (15%)
Query: 88 YMSQMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQ 147
Y+ Q ++ EL+ +++ DL+++ + ++ Q +A + L + + L +
Sbjct: 1061 YLKQTISEKEVELQHIRK-----DLEEK-LAAEEQFQALVKQMNQTLQDKTNQIDLLQAE 1114
Query: 148 INTNKS---KDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQ 204
I+ N++ K +++ + A KE + C S E + E +
Sbjct: 1115 ISENQAIIQKLITSNTDASDGDSVALVKETVV------ISPPCTGSSEHWKPELEEKILA 1168
Query: 205 IVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARD 264
+ Q++ + +A + R+ +++K + E+ HL + LK+Q+ Y + ++ D
Sbjct: 1169 LEKEKEQLQKKLQEALTSRKAILKKAQ-----EKERHLREELKQQKDDYNRLQEQF---D 1220
Query: 265 PQQEPMEEIENLKKQHDLLKR--------MLQQQEQLRALQGRQAALLAL--QHKAEQAI 314
Q + E I + +Q + R QQE + G + L QH + +
Sbjct: 1221 EQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVL 1280
Query: 315 A---VMDDSVVAETAGSLSGVSITSELNEELNDL-IQRFHNQLRDSQPPAVPDNRRQAES 370
D +E A +L G + +++ +L ++ ++ +L+ S + ++ E
Sbjct: 1281 ESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSEL-TKKSEEV 1339
Query: 371 LSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSS 430
L ++++ S + + E+ ++ LQ+K + + L LR+ L
Sbjct: 1340 FQLQEQINKQGLEIESLKTVSHEAEVHAES--LQQKLESSQLQIAGLEHLRE--LQPKLD 1395
Query: 431 SPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTA--SLVSQNESENEGHLNPSE 488
Q+ + ++ S L+ + T + +L +Q E + + H +
Sbjct: 1396 ELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIK 1455
Query: 489 KLQ-KLNEVRKRLNELRELVHYYEQTSDMMTDAV---NENRKDEETEESEYDSEHENSEP 544
+LQ +L E++++ E+ E +Q + A+ E K+ ++ + E E
Sbjct: 1456 QLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIER 1515
Query: 545 VTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCR 604
+T + +V S +AQ N++ TV + + L+ +
Sbjct: 1516 LTK--------SLADVESQVSAQ----NKEKDTVLGRLALLQEERDKLITEMDRSLLENQ 1563
Query: 605 YNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMA 664
+ + +A E++E+ +E + S +SS + E E+++K L
Sbjct: 1564 SLSSSCESLKLALEGLTEDKEKLVKE-------IESLKSSKI---AESTEWQEKHKELQK 1613
Query: 665 AKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDT 724
+ L Q + V+ + + Q V+ A + Y T+ N T
Sbjct: 1614 EYEILLQSYENVS--NEAERIQHVVEAVRQEKQELYGKLRSTEANKKET----------- 1660
Query: 725 GVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDI-QEKIQALQTACPDLQLSAASVGNC 783
E +LQ+ ++E+++++E+ +K Q+KI L+ L+ G+
Sbjct: 1661 -----------EKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDT 1709
Query: 784 PTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQL 843
K+ M + S+ + E K +E + + S M + L EE++ + Q+
Sbjct: 1710 -AKECMETLLSSNASMKEELERVKMEYET-----LSKKFQSLMSEKDSLSEEVQDLKHQI 1763
Query: 844 EALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATW---------GGST 894
E +++ + + + V+ +G++++ + + +M+T S
Sbjct: 1764 EGNVSKQANLEATEKHDNQTNVT--EEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSA 1821
Query: 895 QCALDEEGDEDGYLSEGIVRTDEEEEE----EQDASSNDNFSVCPSNSVNHNSYNGKETK 950
A+ ++ ++ + + D+ +E E++ N FS N N + TK
Sbjct: 1822 NPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKN-TLLSQISTK 1880
Query: 951 NRWKNNCPFSADENYRPLAK--TRQQNISMQRQENLRWVSELSYV--EEKEQWQEQINQL 1006
D + L + T+ ++ Q QE L V++L EEK+ +E++
Sbjct: 1881 -----------DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQ 1929
Query: 1007 KKQLDFSV-SICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQL 1065
+L+ S+ + CQ + D Q + LL++ M L +C ++L
Sbjct: 1930 LAELNGSIGNYCQDVT-DAQIKNELLESE--------------------MKNLKKCVSEL 1968
Query: 1066 TWQQNNVQRLKQMLNELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFN 1125
++ + + K + +R++ + KE G+ + L + +
Sbjct: 1969 EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDC 2028
Query: 1126 IPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQ-QQPLAQNSSGKTEYMAFPKPFE 1184
I S+ + + + +++ E Q + + E +F +
Sbjct: 2029 IRYQEKISALERTVKALEFVQT---ESQKDLEITKENLAQAVEHRKKAQAELASFKVLLD 2085
Query: 1185 SSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQL 1244
+ S A + ++E++S++ + + + E + + N + +L
Sbjct: 2086 DTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL 2145
Query: 1245 DTNGRRRQFDEESL-----------ESFSSMPDPVDPTTVTKTFKTRKASAQASLASKDK 1293
D R + EE++ + + + +D T T+ S+ +
Sbjct: 2146 DALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVI 2205
Query: 1294 TPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHE 1353
K +++ S ++S+ + IR + C K + R + E ++ + SR H+
Sbjct: 2206 DEAKKWERKFSDAIQSKEEEIRLKE----DNCSVLKDQLRQMSIHMEELKINI-SRLEHD 2260
Query: 1354 QLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLL 1413
+ +I + TE+ + + + DT+ E L+SQ E H +EL L
Sbjct: 2261 K--QIWESKAQTEVQLQ--------QKVCDTLQGENKELLSQLEETRHLYHSSQNELAKL 2310
Query: 1414 NTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETF 1473
++ L +L+D ++ +S S EK + K G I E S + +
Sbjct: 2311 ESE------LKSLKDQLT-DLSNSLEKCKEQKGNLEG--IIRQQEADIQNSKFSYEQLET 2361
Query: 1474 EKNFERE-THKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMR-EYERMK 1531
+ RE T ++ E+ + ++S+ S E + A+A +R ++++
Sbjct: 2362 DLQASRELTSRLHEEINMKEQKIISLLSGKEE-----------AIQVAIAELRQQHDKEI 2410
Query: 1532 TEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEET-PVIENRSSQQP------VSEVSTIP 1584
E E+ + I+ + + A N L ET I+ + QQ V +S++
Sbjct: 2411 KELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQ 2470
Query: 1585 CPRI----DTQQLDRQIKAI-----------------MKEVIPFLKEHMDEVCS------ 1617
R D QQL+ + +I +KE I L+ HMD++ S
Sbjct: 2471 NDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLD 2530
Query: 1618 SQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLK---DCGEDL-- 1672
++L+ + +T ++ + K+ ++ Q L++ AK KLK + EDL
Sbjct: 2531 AELIQYREDLNQVITIKDSQQKQLLE-VQLQQNKELENKYAKLE-EKLKESEEANEDLRR 2588
Query: 1673 ----LVEISEVLFNELAFFKLMQDLDNNSITVKQ--------RCKRKIEATGVIQSCA-- 1718
L E + L E+ K+ +T Q + K++ V + A
Sbjct: 2589 SFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALF 2648
Query: 1719 -KEAKRILE----------DHGSPAGEIDD----EDKDKDETETVKQTQTSEVYDGPKNV 1763
KRI E + GEI+D E K + + +T + +
Sbjct: 2649 SSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAEL 2708
Query: 1764 RSDISDQEE-----DEESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDV 1818
D+ + E+ +E++G I +L N +E DE +++ +
Sbjct: 2709 ARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYD---ASL 2765
Query: 1819 QTSLQANTEATEENEHDEQVLQRDFKKTAESKN-----VPLEREATSKNDQ 1864
+ Q + E D + + F + +N L ++ SK++Q
Sbjct: 2766 KELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQ 2816
Score = 53.9 bits (128), Expect = 2e-06
Identities = 126/649 (19%), Positives = 253/649 (38%), Gaps = 117/649 (18%)
Query: 201 ESSQIVSRLVQIRDYITKASSMREDLVEKN--ERSANVERLTHLIDHLKEQEKSYMKFLK 258
E ++ S+++++ KA +++ EKN E++ + L LI+ K+ +
Sbjct: 685 ELERLKSQILELELNFHKA----QEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFT 740
Query: 259 KILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMD 318
+ EE + L Q L + + + Q++ L+ A Q + +
Sbjct: 741 AL---------SEERDQLLSQVKELSMVTELRAQVKQLE-MNLAEAERQRRLDYESQTAH 790
Query: 319 DSVVAETAGSLSGVSITSE-----LNEELNDLIQRFHNQ---LRDSQPPAVPDNRRQAES 370
D+++ E SLS + + + L EL+D+ +F Q +R Q E
Sbjct: 791 DNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG 850
Query: 371 LSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSS 430
R +S S+ S+ L +++E+ ++L EKK+ ++ L + +DQ + S
Sbjct: 851 AERVRHIS-SKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEE-KDQQVTEISF 908
Query: 431 SPQRSVDQRSTSAPSASVGLAPVVNG----------------ESNSLTSSVPY-----PT 469
S + Q + S V + + E N ++S +
Sbjct: 909 SMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSP 968
Query: 470 ASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKD-- 527
A +S+ E ++E L E Q+ +++ L +EL+ + + + + +E++K+
Sbjct: 969 AGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIP 1028
Query: 528 -EETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNC-EIN 585
ETE E + + EN E ++E + V S C EI
Sbjct: 1029 LSETERGEVEEDKENKE-------------YSE----------------KCVTSKCQEIE 1059
Query: 586 NRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSL 645
I E+E+ + D EE+ AEE+ A + +L
Sbjct: 1060 IYLKQTI----------------SEKEVELQHIRKDLEEKLAAEEQ--FQALVKQMNQTL 1101
Query: 646 VDEHPEDAEFEQKINRLMAAKQKLRQLQ------DLVAMVQDDDAAQGVISASASN---- 695
D+ + + +I+ A QKL D VA+V++ + S+ +
Sbjct: 1102 QDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPE 1161
Query: 696 LDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQ----E 751
L++ A E K+ A ++K + +E+ +L+QQ+ + +LQ E
Sbjct: 1162 LEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDE 1221
Query: 752 ERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQ 800
+ K+ +I ++++ LQ +Q+ + G P+ + +STP + +
Sbjct: 1222 QSKENENIGDQLRQLQ-----IQVRESIDGKLPSTDQQESCSSTPGLEE 1265
Score = 53.1 bits (126), Expect = 3e-06
Identities = 308/1747 (17%), Positives = 606/1747 (34%), Gaps = 219/1747 (12%)
Query: 26 DDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPH 85
D +L D Q+++ ++ K K ++ N E G P +
Sbjct: 72 DVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQ 131
Query: 86 SRYMSQMSVPEQAELEKLKQRIN-----FSDLDQRSIGSDSQGRATAANN-------KRQ 133
+ S E+ E+EK+K ++ S L + + ++ A ++ K+Q
Sbjct: 132 LSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQ 191
Query: 134 LSENRKPFNFLPMQINTNKSKDASTSPPNRE--------TIGSAQCKELFASA-LSNDLL 184
L E + + L Q++ +++ A+ + + + +L A + ++
Sbjct: 192 LQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQ 251
Query: 185 QNCQVSEED---------GRGE----------PAMESSQIVSRLVQ--------IRDYIT 217
Q +V + GR + A + +QI+S+ +Q +R+ +
Sbjct: 252 QKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVE 311
Query: 218 KASSMREDLVEK-----NERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPMEE 272
+ L+EK ER + L + HL EQ + + ++ +R E +
Sbjct: 312 TEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHK 371
Query: 273 IENLKKQHDLL---KRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSL 329
E +K +L K + Q AL+ + + L LQ K EQ AV + + L
Sbjct: 372 AEMEEKTSHILSLQKTGQELQSACDALKDQNSKL--LQDKNEQ--AVQSAQTIQQLEDQL 427
Query: 330 SGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQSRKPSASERL 389
S E+++ LN L + H + P V + QA +T E S + E L
Sbjct: 428 QQKS--KEISQFLNRLPLQQHETASQTSFPDVYNEGTQA----VTEENIASLQKRVVE-L 480
Query: 390 PDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVG 449
+EK L L+E K + +KL ++ L Q N + R V + +
Sbjct: 481 ENEKGALLLSSIELEELKAENEKLSSQITLLEAQ---NRTGEADREVSE---------IS 528
Query: 450 LAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQ------KLNEVRKRLNEL 503
+ + N S+S S + SQ E L ++ Q KL KR E
Sbjct: 529 IVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEA 588
Query: 504 RELVHYYEQTSDMMTDAVNENRKDEETEESEYD----SEHENSEPVTNIRNPQV---AST 556
V ++ M + + + E++ D E+S P + T
Sbjct: 589 DHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRT 648
Query: 557 WNEVN-SHSNAQCVSNNRDG-RTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIH 614
E++ + + + S +DG +++++ +I + L L+ N QEI+
Sbjct: 649 SEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLK-SQILELELNFHKAQEIY 707
Query: 615 VAQGEDDEEE----EEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLR 670
++ +E + EE + + SS ++L +E + ++++ + + +++
Sbjct: 708 EKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVK 767
Query: 671 QLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKA 730
QL+ +A + + NL + S + + + + D + +
Sbjct: 768 QLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFS 827
Query: 731 REKFYEAKLQQQ-QRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYM 789
+ LQ Q Q + ++ E +++ I K++ L A +L + +K
Sbjct: 828 EQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKR 887
Query: 790 PAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAE 849
T T+ + + ++ F + + NE L E++ ++QL L
Sbjct: 888 DVETLQQTIEEKDQQVTEISFSMTEKMVQLNE------EKFSLGVEIKTLKEQLNLLSRA 941
Query: 850 HQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTE---------KTMATWGGSTQCALDE 900
+ ++ E + V+ L+ + E Q S+ E K Q AL
Sbjct: 942 EEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALIN 1001
Query: 901 EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFS 960
+ L + + R +EE +D S + P + + + C S
Sbjct: 1002 RKE----LLQRVSRLEEELANLKDESKKE----IPLSETERGEVEEDKENKEYSEKCVTS 1053
Query: 961 ADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKKQLDFSVSICQTL 1020
+ K ++ Q + + E E EQ+Q + Q+ + L + L
Sbjct: 1054 KCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAE--EQFQALVKQMNQTLQDKTNQIDLL 1111
Query: 1021 MQDQQTLSCLLQTLLTGPYSVMPSN----------VASPQVHFIMHQLNQCYTQLTWQQN 1070
+ ++Q L+T + ++ P H + ++ +
Sbjct: 1112 QAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEK 1171
Query: 1071 NVQRLKQMLNELMRQQNQHPEKPGGKERGSSASHPPSPSLF--CPFSFPTQPVNLFNIPG 1128
++L++ L E + + +K KER + F Q NI
Sbjct: 1172 EKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGD 1231
Query: 1129 FTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQQQPLAQNSSGKTEYMA--------FP 1180
+ PS D ++ S+ ++PL + + +P
Sbjct: 1232 QLRQLQIQVRESIDGKLPST--DQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWP 1289
Query: 1181 KPFESSS------SIGAEKPRNKKLPEEEVE-----SSRTPWLYEQEGEV---EKPFIKT 1226
E +S S+ K + K++ E+VE SS T L ++ EV ++ K
Sbjct: 1290 SHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQ 1349
Query: 1227 GFSVSVEKSTSSNRK---NQLDTNGRRRQFDEESLESFSSMPDPVDPTTVTKTFKTRKAS 1283
G + K+ S + L Q LE + +D + K S
Sbjct: 1350 GLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVS 1409
Query: 1284 AQASLASKDKTPKSKSK----------KRNSTQLK-------SRVKNIRYESASMSSTCE 1326
+ S+ + +K + K TQL+ R+K ++ E M E
Sbjct: 1410 YLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPE 1469
Query: 1327 PCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIK---------CNRSTEISSETGSDFSM 1377
+R Q + +QA + SRK + K ++ R T+ ++ S S
Sbjct: 1470 EIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSA 1529
Query: 1378 FEALRDTIYSEVATLISQNESRPHFLIELFHEL----QLLNTDYLRQRALYALQDIVSRH 1433
+DT+ +A L E R + E+ L L ++ + AL L + +
Sbjct: 1530 QNKEKDTVLGRLALL---QEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKL 1586
Query: 1434 ISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKIS--EQNDAD 1491
+ E E ++ K S W + EL + E ER H + Q +
Sbjct: 1587 VKEI-ESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQE 1645
Query: 1492 NASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTE-----AESNSNMRCTCRI 1546
L + + L +++ +MR++ + K + E N +R
Sbjct: 1646 LYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVH- 1704
Query: 1547 IEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIP 1606
AG T ET + N S ++ + V +++ + L ++ +++M E
Sbjct: 1705 -------PAGDTAKECMETLLSSNASMKEELERV------KMEYETLSKKFQSLMSEKDS 1751
Query: 1607 FLKEHMD 1613
+E D
Sbjct: 1752 LSEEVQD 1758
Score = 42.4 bits (98), Expect = 0.005
Identities = 135/713 (18%), Positives = 271/713 (38%), Gaps = 117/713 (16%)
Query: 220 SSMREDLVEKNER-----SANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPMEEIE 274
S + E++ K ++ S E + I L++Q +K L+ +L+++ ++ + E E
Sbjct: 2371 SRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEE 2430
Query: 275 NLK---KQHDLL-------KRMLQQQEQL-------RALQGRQAALLALQHKAEQ---AI 314
N K K + L+ K +QQ+ QL +LQ + ++ + E+ +I
Sbjct: 2431 NKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSI 2490
Query: 315 AVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFH-NQLRDSQPPAVPDNRRQAESLSL 373
+ D ++ E A ++L EE+ L R H + L + + E L+
Sbjct: 2491 ILEKDQLIQEAAAE------NNKLKEEIRGL--RSHMDDLNSENAKLDAELIQYREDLNQ 2542
Query: 374 TREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQ 433
+ S++ E + EL +K L+EK ++ ++ ++ L S ++ Q
Sbjct: 2543 VITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEA--------NEDLRRSFNALQ 2594
Query: 434 RSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKL 493
S S V ++ + + +T+ T L E ++ L
Sbjct: 2595 EEKQDLSKEIESLKVSISQL----TRQVTALQEEGTLGLYHAQLKVKEEEVHRLSAL--F 2648
Query: 494 NEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQV 553
+ +KR+ EL E + ++ + + + K +E + +D+ +E T +V
Sbjct: 2649 SSSQKRIAELEEELVCVQKEAAKKVGEIEDKLK-KELKHLHHDAGIMRNE--TETAEERV 2705
Query: 554 ASTWNE-VNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQE 612
A + V V+ G T A I++ S +E
Sbjct: 2706 AELARDLVEMEQKLLMVTKENKGLT------------AQIQSFGRSMSSLQNSRDHANEE 2753
Query: 613 IHVAQGEDDEEEEEEAE--EEGVSG----ASLSSHRSSLVDEHPEDAEFEQKINRLMAAK 666
+ + + D +E A+ E+G+ A LS S+ +K+N+ + +K
Sbjct: 2754 LDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSK 2813
Query: 667 QKL-----RQLQDLVAMVQDDDAAQGVISASASNL----DDFYPAEEDTKQNS---NNTR 714
+ QL+D VQ A + +L + F +EE ++++ + +
Sbjct: 2814 DEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSP 2873
Query: 715 GNANKTQKDTGVNEKAREKFYEA--KLQQQ----QRELKQLQEERKKLIDIQEKIQALQT 768
+K + R++ + LQQQ +E+ +L + +L + Q+K +A Q
Sbjct: 2874 AEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQI 2933
Query: 769 ACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWS---- 824
+L+ S + H+ KS +E + + + L +
Sbjct: 2934 MQEELRQENLSWQH----------------ELHQLRMEKSSWEIHERRMKEQYLMAISDK 2977
Query: 825 --EMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENL 875
++ + L ELR Q + L ++QR+ +ASP DGS+NL
Sbjct: 2978 DQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASP-------DGSQNL 3023
Score = 35.8 bits (81), Expect = 0.44
Identities = 136/783 (17%), Positives = 297/783 (37%), Gaps = 100/783 (12%)
Query: 1193 KPRNKKLPEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQ 1252
K + +K+ E E E+ R G+ K ++T S ++++ K +L+ +
Sbjct: 1683 KSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLS------SNASMKEELERVKMEYE 1736
Query: 1253 FDEESLESFSSMPDPVDPTTVTKTFKTR-KASAQASLASKDKTPKSKSKKRNSTQLKSRV 1311
+ +S S D + + S QA+L + +K + TQ +
Sbjct: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQ---SI 1793
Query: 1312 KNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNH-----EQLEKIIKCNRSTE 1366
E S+S + P S + SA++ P +K FS + +Q++++ + E
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853
Query: 1367 ISSETGSDFSM-FEALRDTIYSEVAT------LISQNESRPHFLIELFHELQLLNTDYLR 1419
+ +FS E ++T+ S+++T ++ + ++ + L + E +L L+
Sbjct: 1854 EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQE-ELSRVTKLK 1912
Query: 1420 QRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEK---N 1476
+ A D+ R +++ E ++ G + ++ L ++ + +K
Sbjct: 1913 ETAEEEKDDLEERLMNQLAELNGSI-----GNYCQDVTDAQIKNELLESEMKNLKKCVSE 1967
Query: 1477 FERETHKISEQNDADNASVLSVSSNFEPFATDDLGNT--VIHLDQALA-RMREYERMKTE 1533
E E ++ ++ + + A + GN L + L + +E ++++ +
Sbjct: 1968 LEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKD 2027
Query: 1534 A----ESNSNMRCTCRIIE---DGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCP 1586
E S + T + +E T NL + +E+R Q +E+++
Sbjct: 2028 CIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQA--VEHRKKAQ--AELASFKVL 2083
Query: 1587 RIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFH 1646
DTQ ++ A ++ L+ + + V SQ+ + L Q ++ + K
Sbjct: 2084 LDDTQSEAARVLADNLKLKKELQSNKESV-KSQMKQKDEDLERRLEQAEEKHLKEKKNMQ 2142
Query: 1647 KQLGSI------LQDSLAKFA---GRKLKDCGEDLLVEISEVLFNELAFFKLMQDL-DNN 1696
++L ++ L++++ + +K K+ + L + + AF K M L D+
Sbjct: 2143 EKLDALRREKVHLEETIGEIQVTLNKKDKEV-QQLQENLDSTVTQLAAFTKSMSSLQDDR 2201
Query: 1697 SITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPAGE---------------IDDEDKD 1741
+ + K + + + IQS +E R+ ED+ S + I + D
Sbjct: 2202 DRVIDEAKKWERKFSDAIQSKEEEI-RLKEDNCSVLKDQLRQMSIHMEELKINISRLEHD 2260
Query: 1742 KDETETVKQTQ------------------------TSEVYDGPKNVRSDISDQEEDEESE 1777
K E+ QT+ T +Y +N + + + + + +
Sbjct: 2261 KQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQ 2320
Query: 1778 GCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQ 1837
+S +L K + Q G + D + +F ++T LQA+ E T +
Sbjct: 2321 LTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYE--QLETDLQASRELTSRLHEEIN 2378
Query: 1838 VLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDS 1897
+ ++ K ++ Q++ +K N+L E+ N +E+ VD
Sbjct: 2379 MKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELE-NLLSQEEEENIVLEEENKKAVDK 2437
Query: 1898 TQQ 1900
T Q
Sbjct: 2438 TNQ 2440
Score = 35.0 bits (79), Expect = 0.75
Identities = 92/474 (19%), Positives = 193/474 (40%), Gaps = 63/474 (13%)
Query: 1569 ENRSSQQPVSEV-STIPCPRIDTQQLDRQIKAIMKEV------IPFLKEHMDEVCSSQ-- 1619
EN+S Q+ +S TI ++ Q+ A KE + L+E D++ +
Sbjct: 1498 ENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDR 1557
Query: 1620 -------LLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDL 1672
L +S + L L ++ ++ VK S + +S K ++
Sbjct: 1558 SLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEI 1617
Query: 1673 LVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSPA 1732
L++ E + NE + +Q + KQ K+ +T ++ KE ++ L++
Sbjct: 1618 LLQSYENVSNEA---ERIQHVVEAVRQEKQELYGKLRST---EANKKETEKQLQEAEQEM 1671
Query: 1733 GEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDI----------------SDQEEDEES 1776
E+ ++ + ++ KQ + E+ + +R+++ S+ EE
Sbjct: 1672 EEMKEKMRKFAKS---KQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEEL 1728
Query: 1777 EGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDE 1836
E + + Q+L + E ++ EE+++ + ++ S QAN EATE++++
Sbjct: 1729 ERVKMEYETLSKKFQSLMS----EKDSLSEEVQDLKH-QIEGNVSKQANLEATEKHDNQT 1783
Query: 1837 QVLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYLNILEDEQPLNSAAHKE--SPPT 1894
V + ++++P E T + D + +P + + N A K+ S
Sbjct: 1784 NVTEEG------TQSIPGE---TEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDE 1834
Query: 1895 VDS-TQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVL-VNDYEAESG 1952
+++ QQ + L R+ +E + KE E +++L T+ L + E
Sbjct: 1835 INNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM 1894
Query: 1953 NISQKSDEEDFVKVEDLPLKLTIYSEA-DLRKKMVEE-EQKNHLSGEICEMQTE 2004
N+ + +E+ +V LK T E DL ++++ + + N G C+ T+
Sbjct: 1895 NLLNQQIQEELSRV--TKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTD 1946
Score = 32.3 bits (72), Expect = 4.8
Identities = 55/275 (20%), Positives = 108/275 (39%), Gaps = 17/275 (6%)
Query: 596 NMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEF 655
NM LD ++E + E + ED +E AE+ V + + + + E +
Sbjct: 25 NMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQE 84
Query: 656 EQ-----KINRL-MAAKQKLRQLQDLVAMVQDDDAAQG--VISASASNLDDFYPAEEDTK 707
E+ KI +L + AK KL L + ++ AQG V+ + + ++ +
Sbjct: 85 ERKAADNKIKKLKLHAKAKLTSLNKYI----EEMKAQGGTVLPTEPQSEEQLSKHDKSST 140
Query: 708 QNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQ 767
+ +K Q+ + + + +A+ +Q + +++E +QEK + +
Sbjct: 141 EEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFIS 200
Query: 768 TACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMR 827
T L + A + A T V HE + V + + + + +L R
Sbjct: 201 TLQAQLSQTQAEQAAQQVVREKDARFET-QVRLHEDELLQLVTQADVETEMQQKLRVLQR 259
Query: 828 RHEMLREELRQRRKQLEALMAE----HQRRQGLAE 858
+ E E L R + ++ L E QR Q L++
Sbjct: 260 KLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQ 294
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 59.3 bits (142), Expect = 4e-08
Identities = 181/939 (19%), Positives = 358/939 (38%), Gaps = 125/939 (13%)
Query: 177 SALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANV 236
+ + D + N E + + Q +RLV + K ++++ V+K
Sbjct: 426 NGILRDAVSNTTNQLESKQSAELNKLRQDYARLVN--ELTEKTGKLQQEEVQKKNAE--- 480
Query: 237 ERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRAL 296
+ T L L+E E+ + + I R + E Q DL + + ++ ++++L
Sbjct: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAA--------QQDLQSKFVAKENEVQSL 532
Query: 297 QGRQAALLALQHKAEQAIAVMDDSV---VAETAGSLSGVSITSELNEELNDLIQRFHNQL 353
+ L + + EQ + + +S V + V E NE L IQ+FH+Q+
Sbjct: 533 HSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQI 592
Query: 354 RDSQPPAVPDNRRQAESLSLTREVSQSRKPSASER----LPDEKVELFSKMR-VLQEKKQ 408
+V +++ Q+ ASER +E+++ M +L+ + Q
Sbjct: 593 AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
Query: 409 KMDKLLGE----LHTLRDQHLNNSSSSPQ-RSVDQRSTSAPSASVGLAPVVNGESNSLTS 463
K+ L E H L + + R ++++ S + ++N ++ +L S
Sbjct: 653 KLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKS 712
Query: 464 SVPYPTASLVSQNESENEGHLNPSEK-LQKLNEVRKRLNELRELVHYYEQTSDMMTDAVN 522
V +LVS E N+ + EK +Q+ +E K + EL E T + +A+
Sbjct: 713 EVQ-KLQTLVS--EQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR 769
Query: 523 ENRKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNC 582
TE S E ++ + N + AS E+ V + +DG+ + S
Sbjct: 770 -------TENSSLTKEVQDLKAKQNDQ-VSFASLVEELKK------VIHEKDGK-IKSVE 814
Query: 583 EINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHR 642
E+ A ++ N ++ ++ +QEI + E + E+A++ ++
Sbjct: 815 EL--LEAELLKVANKEKTV-----QDLKQEIKALKEEIGNVQLEKAQQLSITSKV----- 862
Query: 643 SSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPA 702
Q++ L+ K++ V ++ D A + L D
Sbjct: 863 --------------QELQNLLKGKEEQMNTMKAVLEEKEKDLAN-----TGKWLQDLQEE 903
Query: 703 EEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKL-IDIQE 761
E K + + K E+ E L++++ ELK+L+ K+ D+
Sbjct: 904 NESLKAHVQEVAQHNLKEASSASQFEEL-----EIVLKEKENELKRLEAMLKERESDLSS 958
Query: 762 KIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNE 821
K Q LQ + +L + + + Y A + P HE K + E E +
Sbjct: 959 KTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPP----HE-ELLKVISEREKEI---SG 1010
Query: 822 LWSEMRRHEMLREELRQRRKQ-----------LEALMAEHQRRQGLAETASPV------A 864
LW+E+ + L++ + +RK+ +EAL + + Q S A
Sbjct: 1011 LWNEL---DSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEA 1067
Query: 865 VSLRSDGSENLCTPQQS-RTEKTMATW-----GGSTQCALDEEGDEDGYLSEGIVRTDEE 918
V L + P+ S + + W + +C G E+ + E ++ +E
Sbjct: 1068 VELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADE 1127
Query: 919 EEEEQDASSNDNFSVCPSNS--VNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNI 976
SV + + ++ +N+WK DE+++ + K Q +
Sbjct: 1128 MHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWK----VKVDESHKTI-KQMQSSF 1182
Query: 977 SMQRQENLRWVSELSYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLT 1036
+ QE R SE +E + +E + ++ + S T +++ + L LQ L
Sbjct: 1183 TSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLD 1242
Query: 1037 GPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRL 1075
YS + +++ + QLN+ T+L +QN Q++
Sbjct: 1243 DSYSEAVRQ--NEELNLLKAQLNETLTKLRTEQNERQKV 1279
Score = 54.7 bits (130), Expect = 9e-07
Identities = 132/722 (18%), Positives = 288/722 (39%), Gaps = 72/722 (9%)
Query: 199 AMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLK 258
A E ++ S+ +++D I + + + V+K + AN E+ + K Q+ Y+K K
Sbjct: 624 ASERDRLTSKEEELKD-IQNMNFLLKAEVQKLQALAN-EQAAAAHELEKMQQSVYVKDDK 681
Query: 259 -KILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVM 317
++L Q E ++E K +D K + + ++L+ L Q ++ + E+ I
Sbjct: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVE-QMEKCIQEK 740
Query: 318 DDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREV 377
D+ + +G+ + EELN + + ++ Q N Q SL E+
Sbjct: 741 DEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND-QVSFASLVEEL 799
Query: 378 SQ------SRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELH------------T 419
+ + S E L E +++ +K + +Q+ KQ++ L E+ T
Sbjct: 800 KKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSIT 859
Query: 420 LRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPV------VNGESNSLTSSVPYPTASLV 473
+ Q L N + ++ LA + E+ SL + V V
Sbjct: 860 SKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQE-----V 914
Query: 474 SQNESENEGHLNPSEKLQ-----KLNEVRKRLNELRELVHYYEQTSDMMTDAVNENR--- 525
+Q+ + + E+L+ K NE+++ L+E + ++ D +EN+
Sbjct: 915 AQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFK 974
Query: 526 ------KDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVN 579
K + +++ HE V + R +++ WNE++S +A ++
Sbjct: 975 SQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLRE 1034
Query: 580 SNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLS 639
N E A+ + L + + ++E +Q++ E E E +E ++ S+
Sbjct: 1035 KNWEAMEALASTEKMLQDKVN---KTSKERQQQV-----EAVELEAKEVLKKLFPKVSVP 1086
Query: 640 SHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDF 699
S+ S H FE+K MA +++ L +++ D ++
Sbjct: 1087 SNLSYGEWLH----GFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSV 1142
Query: 700 YPAEEDTKQN-SNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLID 758
E Q + NK + + K ++ ++ ++EL++L+ E K + +
Sbjct: 1143 LAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM-QSSFTSSEQELERLRSENKDIEN 1201
Query: 759 IQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIV 818
++ + + L+ +L+ + T+ T + + S S++V + E+ +++
Sbjct: 1202 LRREREHLEM---ELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLL 1258
Query: 819 D---NELWSEMRRHEMLRE----ELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDG 871
NE +++R + R+ +L + ++ LE + ++ + G VS ++
Sbjct: 1259 KAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETES 1318
Query: 872 SE 873
SE
Sbjct: 1319 SE 1320
Score = 37.4 bits (85), Expect = 0.15
Identities = 92/456 (20%), Positives = 181/456 (39%), Gaps = 43/456 (9%)
Query: 85 HSRYMSQMSVPEQA---ELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQL----SEN 137
H + ++Q ++ E + + E+L+ + + + + + + + R + ++K QL +
Sbjct: 910 HVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDE 969
Query: 138 RKPFNFLPMQINTNKSKDASTSPPNRETIGSAQCKELFASALSNDL------LQNCQVSE 191
K F Q+ + AS+ PP+ E + +E S L N+L +++ +
Sbjct: 970 NKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKN 1029
Query: 192 EDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLK---- 247
D R + + S ++D + K S R+ VE E A E L L +
Sbjct: 1030 NDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAK-EVLKKLFPKVSVPSN 1088
Query: 248 ----EQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQ--QEQLRALQGRQA 301
E + K K+ +A E ++ +E+ K+ D + +LQ ++ L +
Sbjct: 1089 LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEG 1148
Query: 302 ALLALQHKAEQA----IAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQ 357
L LQ EQ +D+S S S EL E L + N R+ +
Sbjct: 1149 ILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQEL-ERLRSENKDIENLRRERE 1207
Query: 358 PPAVPDNRRQAESLSLTREVSQSRK--PSASERLPDEKVELFSKMRVLQEKKQKMDKLLG 415
+ + + E + EV + + ++L D E + L K ++++ L
Sbjct: 1208 HLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLT 1267
Query: 416 ELHTLRD--QHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLV 473
+L T ++ Q + Q+S++ + A+ + N + + T S T S V
Sbjct: 1268 KLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMS-V 1326
Query: 474 SQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHY 509
S N++ ++ Q L V ++L + +E HY
Sbjct: 1327 SLNQT-------VTQLQQLLQAVNQQLTKEKE--HY 1353
Score = 36.6 bits (83), Expect = 0.26
Identities = 122/624 (19%), Positives = 226/624 (36%), Gaps = 85/624 (13%)
Query: 492 KLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNP 551
++ + K N + +H Q + M + R+ E E + E+ I
Sbjct: 379 RIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQEN-------GILRD 431
Query: 552 QVASTWNEVNSHSNAQCVSNNRD-GRTVNSNCEINNR--------SAANIRALNMPPSLD 602
V++T N++ S +A+ +D R VN E + A A + L
Sbjct: 432 AVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQ 491
Query: 603 CRYNREGEQEIHVAQGEDDEEE-EEEAEEEGVSGAS-LSSHRSSLVDEHPEDAEFEQKIN 660
R E + ++ + + E +++ + + V+ + + S S L D + EQ++
Sbjct: 492 EAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLM 551
Query: 661 RLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKT 720
+LM ++QK ++ + M D Q A + + F+ Q + T +
Sbjct: 552 QLMESEQKRVNKEESLQMQVQDILEQN--EALKAQIQQFH------SQIAAQTSASVLAE 603
Query: 721 QKDTGVNEKARE-KFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAAS 779
+ + EK ++ K E L ++ L +EE K DIQ L+ LQ
Sbjct: 604 ELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELK---DIQNMNFLLKAEVQKLQ----- 655
Query: 780 VGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLR--EELR 837
A+ + HE + +D I L E +HE+ EE +
Sbjct: 656 -----------ALANEQAAAAHELEKMQQSVYVKDDKI---RLLEEQLQHEISNKMEEFK 701
Query: 838 QRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENL--CTPQQSRTEKTMATW--GGS 893
Q +AL +E Q+ Q L V+ D E + C ++ KT+ G
Sbjct: 702 ILNDQNKALKSEVQKLQTL------VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGL 755
Query: 894 TQCALDEEGDEDGYLSEGIVRTDEEE--EEEQDASSNDNFSVCPSNSVNH-----NSYNG 946
Q A EE +RT+ +E QD + N V ++ V + +G
Sbjct: 756 IQVATKEE-------ELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDG 808
Query: 947 KETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQE----NLRWVSELSYVEEKEQWQEQ 1002
K N + +Q I ++E L +LS + ++ Q
Sbjct: 809 KIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNL 868
Query: 1003 INQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMH-----Q 1057
+ ++Q++ ++ + +D LQ L S + ++V H + Q
Sbjct: 869 LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENES-LKAHVQEVAQHNLKEASSASQ 927
Query: 1058 LNQCYTQLTWQQNNVQRLKQMLNE 1081
+ L ++N ++RL+ ML E
Sbjct: 928 FEELEIVLKEKENELKRLEAMLKE 951
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 59.3 bits (142), Expect = 4e-08
Identities = 181/939 (19%), Positives = 358/939 (38%), Gaps = 125/939 (13%)
Query: 177 SALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANV 236
+ + D + N E + + Q +RLV + K ++++ V+K
Sbjct: 426 NGILRDAVSNTTNQLESKQSAELNKLRQDYARLVN--ELTEKTGKLQQEEVQKKNAE--- 480
Query: 237 ERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRAL 296
+ T L L+E E+ + + I R + E Q DL + + ++ ++++L
Sbjct: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAA--------QQDLQSKFVAKENEVQSL 532
Query: 297 QGRQAALLALQHKAEQAIAVMDDSV---VAETAGSLSGVSITSELNEELNDLIQRFHNQL 353
+ L + + EQ + + +S V + V E NE L IQ+FH+Q+
Sbjct: 533 HSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQI 592
Query: 354 RDSQPPAVPDNRRQAESLSLTREVSQSRKPSASER----LPDEKVELFSKMR-VLQEKKQ 408
+V +++ Q+ ASER +E+++ M +L+ + Q
Sbjct: 593 AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
Query: 409 KMDKLLGE----LHTLRDQHLNNSSSSPQ-RSVDQRSTSAPSASVGLAPVVNGESNSLTS 463
K+ L E H L + + R ++++ S + ++N ++ +L S
Sbjct: 653 KLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKS 712
Query: 464 SVPYPTASLVSQNESENEGHLNPSEK-LQKLNEVRKRLNELRELVHYYEQTSDMMTDAVN 522
V +LVS E N+ + EK +Q+ +E K + EL E T + +A+
Sbjct: 713 EVQ-KLQTLVS--EQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR 769
Query: 523 ENRKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNC 582
TE S E ++ + N + AS E+ V + +DG+ + S
Sbjct: 770 -------TENSSLTKEVQDLKAKQNDQ-VSFASLVEELKK------VIHEKDGK-IKSVE 814
Query: 583 EINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHR 642
E+ A ++ N ++ ++ +QEI + E + E+A++ ++
Sbjct: 815 EL--LEAELLKVANKEKTV-----QDLKQEIKALKEEIGNVQLEKAQQLSITSKV----- 862
Query: 643 SSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPA 702
Q++ L+ K++ V ++ D A + L D
Sbjct: 863 --------------QELQNLLKGKEEQMNTMKAVLEEKEKDLAN-----TGKWLQDLQEE 903
Query: 703 EEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKL-IDIQE 761
E K + + K E+ E L++++ ELK+L+ K+ D+
Sbjct: 904 NESLKAHVQEVAQHNLKEASSASQFEEL-----EIVLKEKENELKRLEAMLKERESDLSS 958
Query: 762 KIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNE 821
K Q LQ + +L + + + Y A + P HE K + E E +
Sbjct: 959 KTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPP----HE-ELLKVISEREKEI---SG 1010
Query: 822 LWSEMRRHEMLREELRQRRKQ-----------LEALMAEHQRRQGLAETASPV------A 864
LW+E+ + L++ + +RK+ +EAL + + Q S A
Sbjct: 1011 LWNEL---DSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEA 1067
Query: 865 VSLRSDGSENLCTPQQS-RTEKTMATW-----GGSTQCALDEEGDEDGYLSEGIVRTDEE 918
V L + P+ S + + W + +C G E+ + E ++ +E
Sbjct: 1068 VELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADE 1127
Query: 919 EEEEQDASSNDNFSVCPSNS--VNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNI 976
SV + + ++ +N+WK DE+++ + K Q +
Sbjct: 1128 MHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWK----VKVDESHKTI-KQMQSSF 1182
Query: 977 SMQRQENLRWVSELSYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLT 1036
+ QE R SE +E + +E + ++ + S T +++ + L LQ L
Sbjct: 1183 TSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLD 1242
Query: 1037 GPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRL 1075
YS + +++ + QLN+ T+L +QN Q++
Sbjct: 1243 DSYSEAVRQ--NEELNLLKAQLNETLTKLRTEQNERQKV 1279
Score = 54.7 bits (130), Expect = 9e-07
Identities = 132/722 (18%), Positives = 288/722 (39%), Gaps = 72/722 (9%)
Query: 199 AMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLK 258
A E ++ S+ +++D I + + + V+K + AN E+ + K Q+ Y+K K
Sbjct: 624 ASERDRLTSKEEELKD-IQNMNFLLKAEVQKLQALAN-EQAAAAHELEKMQQSVYVKDDK 681
Query: 259 -KILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVM 317
++L Q E ++E K +D K + + ++L+ L Q ++ + E+ I
Sbjct: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVE-QMEKCIQEK 740
Query: 318 DDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREV 377
D+ + +G+ + EELN + + ++ Q N Q SL E+
Sbjct: 741 DEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND-QVSFASLVEEL 799
Query: 378 SQ------SRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELH------------T 419
+ + S E L E +++ +K + +Q+ KQ++ L E+ T
Sbjct: 800 KKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSIT 859
Query: 420 LRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPV------VNGESNSLTSSVPYPTASLV 473
+ Q L N + ++ LA + E+ SL + V V
Sbjct: 860 SKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQE-----V 914
Query: 474 SQNESENEGHLNPSEKLQ-----KLNEVRKRLNELRELVHYYEQTSDMMTDAVNENR--- 525
+Q+ + + E+L+ K NE+++ L+E + ++ D +EN+
Sbjct: 915 AQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFK 974
Query: 526 ------KDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVN 579
K + +++ HE V + R +++ WNE++S +A ++
Sbjct: 975 SQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLRE 1034
Query: 580 SNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLS 639
N E A+ + L + + ++E +Q++ E E E +E ++ S+
Sbjct: 1035 KNWEAMEALASTEKMLQDKVN---KTSKERQQQV-----EAVELEAKEVLKKLFPKVSVP 1086
Query: 640 SHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDF 699
S+ S H FE+K MA +++ L +++ D ++
Sbjct: 1087 SNLSYGEWLH----GFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSV 1142
Query: 700 YPAEEDTKQN-SNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLID 758
E Q + NK + + K ++ ++ ++EL++L+ E K + +
Sbjct: 1143 LAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM-QSSFTSSEQELERLRSENKDIEN 1201
Query: 759 IQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIV 818
++ + + L+ +L+ + T+ T + + S S++V + E+ +++
Sbjct: 1202 LRREREHLEM---ELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLL 1258
Query: 819 D---NELWSEMRRHEMLRE----ELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDG 871
NE +++R + R+ +L + ++ LE + ++ + G VS ++
Sbjct: 1259 KAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETES 1318
Query: 872 SE 873
SE
Sbjct: 1319 SE 1320
Score = 37.4 bits (85), Expect = 0.15
Identities = 92/456 (20%), Positives = 181/456 (39%), Gaps = 43/456 (9%)
Query: 85 HSRYMSQMSVPEQA---ELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQL----SEN 137
H + ++Q ++ E + + E+L+ + + + + + + + R + ++K QL +
Sbjct: 910 HVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDE 969
Query: 138 RKPFNFLPMQINTNKSKDASTSPPNRETIGSAQCKELFASALSNDL------LQNCQVSE 191
K F Q+ + AS+ PP+ E + +E S L N+L +++ +
Sbjct: 970 NKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKN 1029
Query: 192 EDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLK---- 247
D R + + S ++D + K S R+ VE E A E L L +
Sbjct: 1030 NDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAK-EVLKKLFPKVSVPSN 1088
Query: 248 ----EQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQ--QEQLRALQGRQA 301
E + K K+ +A E ++ +E+ K+ D + +LQ ++ L +
Sbjct: 1089 LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEG 1148
Query: 302 ALLALQHKAEQA----IAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQ 357
L LQ EQ +D+S S S EL E L + N R+ +
Sbjct: 1149 ILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQEL-ERLRSENKDIENLRRERE 1207
Query: 358 PPAVPDNRRQAESLSLTREVSQSRK--PSASERLPDEKVELFSKMRVLQEKKQKMDKLLG 415
+ + + E + EV + + ++L D E + L K ++++ L
Sbjct: 1208 HLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLT 1267
Query: 416 ELHTLRD--QHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLV 473
+L T ++ Q + Q+S++ + A+ + N + + T S T S V
Sbjct: 1268 KLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMS-V 1326
Query: 474 SQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHY 509
S N++ ++ Q L V ++L + +E HY
Sbjct: 1327 SLNQT-------VTQLQQLLQAVNQQLTKEKE--HY 1353
Score = 36.6 bits (83), Expect = 0.26
Identities = 122/624 (19%), Positives = 226/624 (36%), Gaps = 85/624 (13%)
Query: 492 KLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNP 551
++ + K N + +H Q + M + R+ E E + E+ I
Sbjct: 379 RIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQEN-------GILRD 431
Query: 552 QVASTWNEVNSHSNAQCVSNNRD-GRTVNSNCEINNR--------SAANIRALNMPPSLD 602
V++T N++ S +A+ +D R VN E + A A + L
Sbjct: 432 AVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQ 491
Query: 603 CRYNREGEQEIHVAQGEDDEEE-EEEAEEEGVSGAS-LSSHRSSLVDEHPEDAEFEQKIN 660
R E + ++ + + E +++ + + V+ + + S S L D + EQ++
Sbjct: 492 EAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLM 551
Query: 661 RLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKT 720
+LM ++QK ++ + M D Q A + + F+ Q + T +
Sbjct: 552 QLMESEQKRVNKEESLQMQVQDILEQN--EALKAQIQQFH------SQIAAQTSASVLAE 603
Query: 721 QKDTGVNEKARE-KFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAAS 779
+ + EK ++ K E L ++ L +EE K DIQ L+ LQ
Sbjct: 604 ELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELK---DIQNMNFLLKAEVQKLQ----- 655
Query: 780 VGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLR--EELR 837
A+ + HE + +D I L E +HE+ EE +
Sbjct: 656 -----------ALANEQAAAAHELEKMQQSVYVKDDKI---RLLEEQLQHEISNKMEEFK 701
Query: 838 QRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENL--CTPQQSRTEKTMATW--GGS 893
Q +AL +E Q+ Q L V+ D E + C ++ KT+ G
Sbjct: 702 ILNDQNKALKSEVQKLQTL------VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGL 755
Query: 894 TQCALDEEGDEDGYLSEGIVRTDEEE--EEEQDASSNDNFSVCPSNSVNH-----NSYNG 946
Q A EE +RT+ +E QD + N V ++ V + +G
Sbjct: 756 IQVATKEE-------ELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDG 808
Query: 947 KETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQE----NLRWVSELSYVEEKEQWQEQ 1002
K N + +Q I ++E L +LS + ++ Q
Sbjct: 809 KIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNL 868
Query: 1003 INQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMH-----Q 1057
+ ++Q++ ++ + +D LQ L S + ++V H + Q
Sbjct: 869 LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENES-LKAHVQEVAQHNLKEASSASQ 927
Query: 1058 LNQCYTQLTWQQNNVQRLKQMLNE 1081
+ L ++N ++RL+ ML E
Sbjct: 928 FEELEIVLKEKENELKRLEAMLKE 951
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 58.5 bits (140), Expect = 6e-08
Identities = 177/896 (19%), Positives = 346/896 (38%), Gaps = 142/896 (15%)
Query: 147 QINTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIV 206
+I+ S+ + +E + + K A L Q + E+ G + E +Q+
Sbjct: 362 RIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGL-QLQSEINQLH 420
Query: 207 SRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQ 266
S+L++ + +A K +R + E+L KEQ+ + ++ L+R +
Sbjct: 421 SKLLETERQLGEAHGRL-----KEQRQLSSEKLMD-----KEQQVADLQLK---LSRLEE 467
Query: 267 QEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDD------S 320
Q + + + QH L K Q QEQ Q A L Q+ EQ + + D +
Sbjct: 468 QLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN 527
Query: 321 VVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREV--- 377
+ A S +S+ + E+L IQ + ++ Q + LT ++
Sbjct: 528 LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQ 587
Query: 378 SQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVD 437
S+S K A E L D+ E + +R Q++ ++ + EL++ LN S +
Sbjct: 588 SESHK-QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS----QLNESKEKVSQ--- 639
Query: 438 QRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVR 497
L + ++ L S+ TA ++ + HL+ ++ N ++
Sbjct: 640 ------------LDIQIKAKTELLLSAEAAKTA-----QRADLQNHLDTAQ-----NALQ 677
Query: 498 KRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTW 557
+ EL ++ +Q + + D E+ E+ EY ++ + E T Q+
Sbjct: 678 DKQQELNKITTQLDQVTAKLQDK-QEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL- 735
Query: 558 NEVNS----HSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEI 613
E +S S Q + + + R +N++ E +RA + L E E+EI
Sbjct: 736 -EADSLEVKASKEQALQDLQQQRQLNTDLE--------LRATELSKQL------EMEKEI 780
Query: 614 HVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQ 673
V+ D +++ EA E + ++ + E E KI ++ ++Q
Sbjct: 781 -VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH----EELNNRIQ 835
Query: 674 DLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREK 733
V +Q + + S + D D+ +NS + N+ K ++ + K
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895
Query: 734 FYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVT 793
+ +LQ Q + Q+E KK ++ +++ A L+L S+ +
Sbjct: 896 ELKHQLQVQMENTLKEQKELKKSLEKEKE------ASHQLKLELNSMQE-------QLIQ 942
Query: 794 STPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMA----- 848
+ T+ Q+ E E+ + N L++ Q++KQ+EAL
Sbjct: 943 AQNTLKQN---------EKEEQQLQGN--------INELKQSSEQKKKQIEALQGELKIA 985
Query: 849 -------EHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEE 901
E++ +Q L + A +A + + Q+ EK+ T+ Q D
Sbjct: 986 VLQKTELENKLQQQLTQAAQELA------AEKEKISVLQNNYEKSQETF---KQLQSDFY 1036
Query: 902 GDEDGYLSEGIVRTDEEEEEE------QDASSNDNFSVCPSNSVNHNSYNGKETKNRWKN 955
G E L+ R D + EE +D SN N + N + K T +
Sbjct: 1037 GRESELLA---TRQDLKSVEEKLSLAQEDLISNRN-QIGNQNKLIQELKTAKATLEQDSA 1092
Query: 956 NCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEE-KEQWQEQINQLKKQL 1010
E + L +++ S++ +E + S+L+ +EE K + +++I +L ++L
Sbjct: 1093 KKEQQLQERCKALQDIQKEK-SLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEEL 1147
Score = 51.6 bits (122), Expect = 8e-06
Identities = 55/247 (22%), Positives = 109/247 (44%), Gaps = 32/247 (12%)
Query: 181 NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLT 240
N L+Q + ++ + A + Q+ R ++D + S ++LV + + A +E +
Sbjct: 1074 NKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK 1133
Query: 241 HLIDHLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQ 300
QEK K +++ + + E ++EI NLK LL +QQ+ +L QG+
Sbjct: 1134 C------RQEKEITKLNEEL--KSHKLESIKEITNLKDAKQLL---IQQKLEL---QGKA 1179
Query: 301 AALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA 360
+L A + ++ ++ D V E EL +E + + H+++++ +
Sbjct: 1180 DSLKAAVEQEKRNQQILKDQVKKEE----------EELKKEFIEKEAKLHSEIKEKE--- 1226
Query: 361 VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTL 420
V + + LT +++ + +E L K E S R + E +++ D L GE+ L
Sbjct: 1227 VGMKKHEENEAKLTMQIT-----ALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVL 1281
Query: 421 RDQHLNN 427
NN
Sbjct: 1282 EATVQNN 1288
Score = 47.0 bits (110), Expect = 2e-04
Identities = 137/759 (18%), Positives = 299/759 (39%), Gaps = 98/759 (12%)
Query: 1302 RNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKII-- 1359
R QLK +V N S + + K +++ ++ AK+ R+ LE+++
Sbjct: 464 RLEEQLKEKVTN----STELQHQLDKTKQQHQEQQALQQSTTAKL--REAQNDLEQVLRQ 517
Query: 1360 ------KCNRSTEISSETGSDFSMFEALRDTIYSEV------ATLISQNESRPHFLIELF 1407
K + ++ + S+ E R+ +Y+++ +++Q + + H L E
Sbjct: 518 IGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQV 577
Query: 1408 HEL--QLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESL 1465
+L +L N ++A L D V + + V S+ + NS+L S+
Sbjct: 578 TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV-NELNSQLNESKEK 636
Query: 1466 ATTDDETFEKNFE----RETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQAL 1521
+ D + E E K +++ D N L + N +L LDQ
Sbjct: 637 VSQLDIQIKAKTELLLSAEAAKTAQRADLQNH--LDTAQNALQDKQQELNKITTQLDQVT 694
Query: 1522 ARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVS 1581
A++++ + ++ ES+ + + + LE + S +Q + ++
Sbjct: 695 AKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQ 754
Query: 1582 TIPCPRIDTQ----QLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDE 1637
D + +L +Q++ + KE++ + +D S+ L S+++ LT+Q +E
Sbjct: 755 QQRQLNTDLELRATELSKQLE-MEKEIVSSTR--LDLQKKSEALESIKQK---LTKQEEE 808
Query: 1638 SK----------EFVKFFHKQLGSILQDSLAKFAGRKLK--------DCGEDLLVEISEV 1679
+ + K H++L + +Q ++ + K++ +D L ++S+
Sbjct: 809 KQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS 868
Query: 1680 LFNELAFFK--------LMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGSP 1731
L N + F+ + DL+ +K + + ++E T Q KE K+ LE
Sbjct: 869 LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQ---KELKKSLEKEKEA 925
Query: 1732 AGEIDDEDKDKDET-----ETVKQTQTSEVY-DGPKNVRSDISDQEEDEESEGCPVSINL 1785
+ ++ E E T+KQ + E G N S+Q++ ++ E + +
Sbjct: 926 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKK-KQIEALQGELKI 984
Query: 1786 SKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHD-----EQVL- 1839
+ + L N + +E+ +E +Q + + + E ++ + D ++L
Sbjct: 985 AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044
Query: 1840 -QRDFKKTAESKNVPLEREATSKNDQNNC-----PVKPCYLNILEDEQPLNSAAHKESPP 1893
++D K E ++ E +++N N +K + +D +
Sbjct: 1045 TRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKA 1104
Query: 1894 TVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAESGN 1953
D ++ + L + + ++E+K QE + L + + +S L + E
Sbjct: 1105 LQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKL--NEELKSHKLESIKE----- 1157
Query: 1954 ISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKN 1992
I+ D + + + KL + +AD K VE+E++N
Sbjct: 1158 ITNLKDAKQLL----IQQKLELQGKADSLKAAVEQEKRN 1192
Score = 38.1 bits (87), Expect = 0.088
Identities = 118/676 (17%), Positives = 256/676 (37%), Gaps = 106/676 (15%)
Query: 1359 IKCNRSTEISSETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYL 1418
++ + E + + + S E + +E L Q E + ++L E+ L++ L
Sbjct: 365 VELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLL 424
Query: 1419 RQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSE-SLATTDDETFEK-- 1475
R + E+H + + + ++S + ++ + L+ +++ EK
Sbjct: 425 E----------TERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVT 474
Query: 1476 ---NFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKT 1532
+ + K +Q+ A S ++ A +DL + + +++ E +
Sbjct: 475 NSTELQHQLDKTKQQHQEQQALQQSTTAKLRE-AQNDLEQVLRQIGDKDQKIQNLEALLQ 533
Query: 1533 EAESNSNMRCTCRI-----IEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPR 1587
+++ N ++ R I+ G+G A +N L+E +N + Q+ V++++ +
Sbjct: 534 KSKENISLLEKEREDLYAKIQAGEGETA--VLNQLQE----KNHTLQEQVTQLTEKLKNQ 587
Query: 1588 IDT-QQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFH 1646
++ +Q + ++E L+ D V S L TSV L Q +ESKE V
Sbjct: 588 SESHKQAQENLHDQVQEQKAHLRAAQDRVLS--LETSVNE----LNSQLNESKEKVSQLD 641
Query: 1647 KQLGS----ILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQ 1702
Q+ + +L AK A R DL N+ T +
Sbjct: 642 IQIKAKTELLLSAEAAKTAQRA---------------------------DLQNHLDTAQN 674
Query: 1703 RCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKN 1762
+ K + I + + L+D +++ K+ E + +T E+ K
Sbjct: 675 ALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKK 734
Query: 1763 VRSDISDQEEDEESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSL 1822
+ +D S+ + ++ QAL + N D E+ E + L
Sbjct: 735 LEAD---------------SLEVKASKEQALQDLQQQRQLNTDLELRATE-----LSKQL 774
Query: 1823 QANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYLNILEDEQP 1882
+ E D Q KK+ +++ ++ +K ++ +K + + ++ +
Sbjct: 775 EMEKEIVSSTRLDLQ------KKSEALESI---KQKLTKQEEEKQILKQDFETLSQETKI 825
Query: 1883 LNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAGSPDTESPV 1942
+ + TV Q+ E E L+ + VK SL S +S
Sbjct: 826 QHEELNNRIQTTVTELQKVKM------EKEALMTELSTVKDKLSKVSDSLKNS---KSEF 876
Query: 1943 LVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKNH-LSGEICEM 2001
+ + ++ + + ++ + ++ T+ + +L+K + +E++ +H L E+ M
Sbjct: 877 EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSM 936
Query: 2002 QTEELAGNSETLKEPE 2017
Q E+L TLK+ E
Sbjct: 937 Q-EQLIQAQNTLKQNE 951
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 57.8 bits (138), Expect = 1e-07
Identities = 199/1107 (17%), Positives = 394/1107 (35%), Gaps = 107/1107 (9%)
Query: 36 AQQKKANRSSEKNKKKFGVESDKRVTNDISPES----SPGVGRRRTKTPHTFPHSRYMSQ 91
AQ+++A +E+ +++ ES ++ ++ S R + + R ++
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546
Query: 92 MSVPE--QAELEKLKQRINFSDLDQRSIGSDSQG-RATAANNKRQLSENRKPFNFLPMQI 148
+ QAE+E+ +Q + QRS ++ Q RA+ A QL + + + Q+
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 149 NTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSR 208
+ A A+ +EL L + ++ E+ + ++ ++ +
Sbjct: 1607 REEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665
Query: 209 LVQIRDYITKASSMREDLVEKNERSAN-VERLTHLIDHLKEQEKSYMKFLKKILARDPQQ 267
+ + E V + E + +E+ L + +Q + + L ++ A Q
Sbjct: 1666 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 268 EPM-----EEIENLKKQHDLLKRMLQQQE-QLRALQGRQAALLALQHKAEQAIAVMDDSV 321
E EE+ L+++ + Q+ E +L ++ LLA + +AE+ +
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 322 VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRR-------------QA 368
+E L L + Q + ++ A +A
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1845
Query: 369 ESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEK----KQKMDKLLGELHTLRDQH 424
L E++ K + +ERL + + R L+E+ K +++ L +L D
Sbjct: 1846 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1905
Query: 425 LNNSSSSPQRSVDQR-----STSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESE 479
L + ++ QR A AS A E L + ++ S+
Sbjct: 1906 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSNAEDTLRSK 1962
Query: 480 NEGHLNPSEKLQKLNEVRKRLNELRELVHYY----EQTSDMMTDAVNE-NRKDEETEESE 534
+ L + + Q E +R E E V E+ + A+ E R + EE+
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2022
Query: 535 YDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRA 594
E E ++ Q A+ + + A + + + + + +R
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR- 2080
Query: 595 LNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAE 654
GE E E+ EE +AE E L E A+
Sbjct: 2081 --------------GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126
Query: 655 FEQKINRLMAAKQKLRQL--QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNN 712
+ AA +KLR+ Q+ Q + AA A+ + ++ E T
Sbjct: 2127 ARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT------ 2177
Query: 713 TRGNANKTQKDTGVNEKAREKFYEAKL--QQQQRELKQLQEERKKLIDIQEKIQALQTAC 770
R A Q+ T + + E ++ L ++ QR + E ++ ++E++ +++
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2237
Query: 771 PDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHE 830
+L A + + +T Q E K V E+++ + R +
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV--AEEAARLSVAAQEAARLRQ 2295
Query: 831 MLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATW 890
+ E+L Q+R E ++ E + Q + E A + + L Q R ++
Sbjct: 2296 LAEEDLAQQRALAEKMLKE--KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353
Query: 891 GGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQ-DASSNDNFSVCPSNSVNHNSYNGKET 949
L EE ++G RT E E + Q + S+ ++ +E
Sbjct: 2354 AQQ----LAEE-------TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2402
Query: 950 KNRWKNNCPFSADENYRPLAKTRQ-----QNISMQRQENLRWVSEL-SYVEEKEQWQEQI 1003
R++ ++ +R T++ Q + +QRQ++ L + E E+ +E++
Sbjct: 2403 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2462
Query: 1004 NQLKKQLDFSVSICQTLMQDQ--QTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQC 1061
Q K L QT+ Q+Q Q L Q+ L+ S++ Q + QL
Sbjct: 2463 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--- 2519
Query: 1062 YTQLTWQQNNVQRLKQMLNELMRQQNQ 1088
Q+ V + +Q+ E RQQ Q
Sbjct: 2520 ------FQDEVAKAQQLREEQQRQQQQ 2540
Score = 52.0 bits (123), Expect = 6e-06
Identities = 187/1043 (17%), Positives = 385/1043 (36%), Gaps = 122/1043 (11%)
Query: 14 DQDLPNW---SNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSP 70
+++L W +NE + RL + Q+ A +EK K++ E+ +R ++
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR------GKAEE 1681
Query: 71 GVGRRRTKTPHTFPHSRYMSQMSVPEQ--AELEKLKQRINFSDLDQ-RSIGSDSQGR--- 124
R+R R +++ + ++ AE E ++ R +Q R + + R
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1741
Query: 125 -ATAANNKRQ-----LSENRKPFNFLPMQINTNKSKDASTSPPNRETIGS--AQCKELFA 176
A AA KRQ L++ R L + + STS +++ + + + +EL
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Query: 177 SA-----LSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNE 231
A L+ + + Q++EED + A + +L I + T+ + E + E
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE-ATRLKTEAE--IALKE 1858
Query: 232 RSANVERLTHLID-------HLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLK 284
+ A ERL L + L+EQ + +++ LA+ + E L++Q L++
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLVE 1914
Query: 285 RMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELND 344
L+Q+ Q+ + +LAL+ E+A A + L I S + L
Sbjct: 1915 DTLRQRRQV------EEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRS 1961
Query: 345 LIQRFHNQLRDSQPPAVPDNRRQA------ESLSLTREVSQSRKPSASERLPDEKVELFS 398
Q R Q A + RR+ +SL+ E ++ RK +A E + K ++
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEE 2020
Query: 399 KMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGES 458
R+ + +Q+ + L + L + +V Q+ L + E
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-------LQQTLQQEQ 2073
Query: 459 NSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMT 518
+ L A+ + E+E E Q +V + L++ Q
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAEEQAQARAQAQ 2132
Query: 519 DAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTV 578
A + RK+ E E + + + +R Q A E + Q +
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAA-----LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Query: 579 NSNCEIN--------NRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE 630
+ + N ++ L + R + E+E+ + + +E + +A
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2247
Query: 631 EGVSGASLSSHRSS----LVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQ 686
E + A + + + L +E + + ++ RL A Q+ +L+ L ++D AQ
Sbjct: 2248 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA----EEDLAQ 2303
Query: 687 GVISASASNLDDFYPAEEDT--KQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQR 744
A + +E T K + + Q+ ++ +E+ + ++ Q
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363
Query: 745 ELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETS 804
+ L+ ER++ +++ + + L+ ++ + A + A +++ E +
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 805 TSKSV-------FEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQ--RRQG 855
T + V + + S L + E +E+L+Q K L+ E Q +++
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483
Query: 856 LAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRT 915
L + + S S+ L + EK Q DE +++
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE-----QLFQDE-------VAKAQQLR 2531
Query: 916 DEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQN 975
+E++ ++Q V + +E R E + L + R+Q
Sbjct: 2532 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--------KQEELQQLEQQRRQQ 2583
Query: 976 ISMQRQENLRWVSELSYVEEKEQ 998
+ +EN R +L +EE+ +
Sbjct: 2584 EELLAEENQRLREQLQLLEEQHR 2606
Score = 45.8 bits (107), Expect = 4e-04
Identities = 145/779 (18%), Positives = 283/779 (36%), Gaps = 99/779 (12%)
Query: 197 EPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKF 256
EP+ + + S L + + S+ +EK + + V R T + + + +K
Sbjct: 1055 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1114
Query: 257 LKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAV 316
+ + A P+ E + +LKK L + QQ AL+ + + +Q
Sbjct: 1115 AQAVPATLPELEATKA--SLKK---LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1169
Query: 317 MDDSV------VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA---VPDNRRQ 367
D V VA+ V +++ + + + R R+S P + D RR+
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1229
Query: 368 AESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNN 427
E + P A + E++ + + L E+ ++ + + E Q++N
Sbjct: 1230 QEQIQAM--------PLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINA 1278
Query: 428 SSSSPQRSVDQRSTSAPSASVGLAPVVNGESNS-----------------LTSS-VPYPT 469
+ V ++ P AS P V S S LTS + + +
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338
Query: 470 ASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNE--NRKD 527
+L E E +E+ ++L EV L + R+L + Q E R
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 528 EET---EESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEI 584
EE EE+ D++ + + ++ S A+ + R + +
Sbjct: 1399 EEVVRREEAAVDAQQQKRS---------IQEELQQLRQSSEAEIQAKARQAEAAERS-RL 1448
Query: 585 NNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSS 644
+ L + + R EGE + A+ E+ E ++ +A+EE R
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQ 1502
Query: 645 LVDEHPEDAEFEQKINRLM-----AAKQKLRQLQDLVAM-VQDDDAAQGVISASASNLDD 698
+ DE + E ++ + AA++K R LQ L + +Q ++A + + A
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562
Query: 699 FYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLID 758
A E ++++ A K EK + E LQ++ + QL+EE ++
Sbjct: 1563 VQVALETAQRSA-----EAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREEAERRAQ 1615
Query: 759 IQ-EKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSI 817
Q E +A + A +L+ + + E + KS+ + E
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLR----------LQAEEVAQQKSLAQAEAEKQ 1665
Query: 818 VDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAE---TASPVAVSLRSDGSEN 874
+ RR + + +RQR + L + Q +G A+ A + LR++ +
Sbjct: 1666 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 875 LCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLS------EGIVRTDEEEEEEQDASS 927
Q+ E+ +A A + + + L+ E ++ + EEE ++S
Sbjct: 1726 --EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782
Score = 43.1 bits (100), Expect = 0.003
Identities = 127/677 (18%), Positives = 251/677 (37%), Gaps = 80/677 (11%)
Query: 218 KASSMREDLVEKNER-SANVERLTHLIDHLKEQEKSYMKFLKKILARDPQ-QEPMEEIEN 275
+A+ R+ +E+ ER A VE L + +++ ++ ++ + Q +E
Sbjct: 1999 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2058
Query: 276 LKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSIT 335
+K+ +L + + Q+Q L L+G A +AE+A + E A S V
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE----REAAQSRRQVEEA 2114
Query: 336 SELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQS----RKPSASERLPD 391
L + + Q R A R++AE + R ++ +K +A +
Sbjct: 2115 ERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2169
Query: 392 EKVELFSKMRVLQEKKQKMDKLLGELH------TLRDQHLNNSSSSPQRSVDQRSTSAPS 445
K +R + +Q++ L +L L D+ L + + QRS
Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV--E 2227
Query: 446 ASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNP-SEKLQKLNEVRKRLN--- 501
+ V E + L + + +L+ +++ + L +EK++++ E RL+
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 502 ----ELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTW 557
LR+L + + + + + E + +E E + + Q
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL- 2346
Query: 558 NEVNSHSNAQCVSNNRDG--RTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHV 615
+ + AQ ++ G RT+ + + +A L + R E
Sbjct: 2347 -QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---------RVAEMSRAQ 2396
Query: 616 AQGEDDEEE-EEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQD 674
A+ E+D + ++AEE G HR+ L + +I R + R +
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEK-----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2451
Query: 675 LVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKF 734
+ + ++ + Q ++ +++ + ++KD+ + RE+F
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ---RERF 2508
Query: 735 YEAKLQQQQRELKQL-QEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVT 793
E Q++ +L+QL Q+E K ++E+ Q Q ++ + A
Sbjct: 2509 IE----QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ------------ERQRLVASM 2552
Query: 794 STPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRR 853
QHE + E + E E+L EE ++ R+QL+ L E Q R
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----ELLAEENQRLREQLQLL--EEQHR 2606
Query: 854 QGLAE----TASPVAVS 866
LA TAS VA +
Sbjct: 2607 AALAHSEEVTASQVAAT 2623
Score = 41.2 bits (95), Expect = 0.010
Identities = 176/929 (18%), Positives = 336/929 (36%), Gaps = 106/929 (11%)
Query: 224 EDLVEKNERSANVERLTHLIDHLKEQEK-----SYMKFLKKILARDPQQEPMEEIENLKK 278
E+ + + +R+ ERL + L++Q + + K + A++ QQ EE+ ++
Sbjct: 1347 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406
Query: 279 QH-DLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSE 337
D ++ QE+L+ L RQ++ +Q KA QA A + E + V + E
Sbjct: 1407 AAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEE--EIRVVRLQLE 1462
Query: 338 LNEELNDLIQRFHNQLRDSQPPAVPDNRR-QAESLSLTREVSQSRKPSASERLPDEKVEL 396
E + LR A R+ Q E+ L R+V S+R +VEL
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----SQRKRQAEVEL 1517
Query: 397 FSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNG 456
S+++ E ++ + L L LR Q Q V+ R+ A
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRSAEA 1576
Query: 457 ESNSLTSSVPYPTASL----------VSQNESENEGHLNPSEKLQKLNEVRKR------- 499
E S +S TA L V+Q E E + ++ E +R
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1636
Query: 500 -LNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRN--PQVAST 556
NE L E+ + + A E K +E E E + E R Q
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1696
Query: 557 WNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAA----NIRALNMPPSLDCRYNREGEQE 612
++ + Q ++ ++ + + E + + L + + +E E E
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1756
Query: 613 IHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQL 672
+ + E + +A E S ++ + L E E ++ RL A ++ ++
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816
Query: 673 QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAR- 731
+ L ++DAA+ A + E T+ + K ++ + A
Sbjct: 1817 RQLA----EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Query: 732 EKFYEAKLQQQ--------QRELKQLQ-------EERKKLID--------IQEKIQALQT 768
E F +L++Q + L QL+ E +K L++ ++E+I AL+
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1932
Query: 769 ACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRR 828
+ A+ G + + + S N +T SK E E + R+
Sbjct: 1933 S-----FEKAAAGKAELELELGRIRS----NAEDTLRSKEQAELEAA-----------RQ 1972
Query: 829 HEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMA 888
++ EE R+RR+ E + Q+ E A+ + + +++R + A
Sbjct: 1973 RQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2028
Query: 889 TWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKE 948
+ Q L +E + +E +++EQ+ ++ SV E
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ----TLQQEQSVLDQLRGEAE 2084
Query: 949 TKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKK 1008
R + + R A++R+Q ++ E L+ +E + + Q Q +L+K
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQ---VEEAERLKQSAE-EQAQARAQAQAAAEKLRK 2140
Query: 1009 QLDFSVS----ICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQ-VHFIMHQLNQCYT 1063
+ + + Q ++ +Q ++ + Q + + QL +
Sbjct: 2141 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2200
Query: 1064 QLTWQQNNVQRLKQMLNELMRQQNQHPEK 1092
Q +QRLK E RQ++Q E+
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEE 2229
Score = 38.9 bits (89), Expect = 0.052
Identities = 105/631 (16%), Positives = 241/631 (38%), Gaps = 60/631 (9%)
Query: 1419 RQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFE 1478
+QRAL AL+++ R +E E+ V + L ++ A + ++ +F
Sbjct: 1531 KQRALQALEEL--RLQAEEAERRLRQAEVERARQV--QVALETAQRSAEAELQSKRASFA 1586
Query: 1479 RETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARM-REYERMKTEAESN 1537
+T ++ ++ +V + E A ++A RE ER + +A
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQA-----EAERAREEAERELERWQLKANEA 1641
Query: 1538 SNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQI 1597
+R + EE E + ++ +E + + Q+L++Q
Sbjct: 1642 LRLRLQAEEVAQQKSLAQAEAEKQKEEA---EREARRRGKAEEQAVRQRELAEQELEKQ- 1697
Query: 1598 KAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSL 1657
+ E + Q L + + ++ L + ++ ++ + ++L + +++
Sbjct: 1698 ------------RQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAA 1744
Query: 1658 AKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEA-TGVIQS 1716
A R ++L E+++V + S + ++ K+++EA G +
Sbjct: 1745 AATQKR------QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798
Query: 1717 CAKEAKRI--LEDHGSPAGEIDDED--KDKDETETVKQTQTSEVYDGPK-NVRSDISDQE 1771
A+EA R+ L + ++ +ED + + E E V + + + + + ++I+ +E
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858
Query: 1772 EDEESEGC-----PVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANT 1826
++ E+E + + E QA + + E ++ + + ++ Q L +T
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSELERQKGLVEDT 1916
Query: 1827 -EATEENEHDEQVLQRDFKKTAESK---NVPLEREATSKND----QNNCPVKPCYLNIL- 1877
+ E + L+ F+K A K + L R ++ D + ++ L
Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 1878 -EDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAG-- 1934
E+E+ A + + L E+E L +V+E + +E E A
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036
Query: 1935 --SPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKN 1992
+ + L + +A + + QK E ++ + + EA+ ++ EE ++
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096
Query: 1993 HLSGEICEMQTEELAGNSETLKEPETVGAQS 2023
+ E Q+ +E LK+ AQ+
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 57.8 bits (138), Expect = 1e-07
Identities = 199/1107 (17%), Positives = 394/1107 (35%), Gaps = 107/1107 (9%)
Query: 36 AQQKKANRSSEKNKKKFGVESDKRVTNDISPES----SPGVGRRRTKTPHTFPHSRYMSQ 91
AQ+++A +E+ +++ ES ++ ++ S R + + R ++
Sbjct: 1491 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1550
Query: 92 MSVPE--QAELEKLKQRINFSDLDQRSIGSDSQG-RATAANNKRQLSENRKPFNFLPMQI 148
+ QAE+E+ +Q + QRS ++ Q RA+ A QL + + + Q+
Sbjct: 1551 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1610
Query: 149 NTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSR 208
+ A A+ +EL L + ++ E+ + ++ ++ +
Sbjct: 1611 REEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1669
Query: 209 LVQIRDYITKASSMREDLVEKNERSAN-VERLTHLIDHLKEQEKSYMKFLKKILARDPQQ 267
+ + E V + E + +E+ L + +Q + + L ++ A Q
Sbjct: 1670 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1729
Query: 268 EPM-----EEIENLKKQHDLLKRMLQQQE-QLRALQGRQAALLALQHKAEQAIAVMDDSV 321
E EE+ L+++ + Q+ E +L ++ LLA + +AE+ +
Sbjct: 1730 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1789
Query: 322 VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRR-------------QA 368
+E L L + Q + ++ A +A
Sbjct: 1790 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1849
Query: 369 ESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEK----KQKMDKLLGELHTLRDQH 424
L E++ K + +ERL + + R L+E+ K +++ L +L D
Sbjct: 1850 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1909
Query: 425 LNNSSSSPQRSVDQR-----STSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESE 479
L + ++ QR A AS A E L + ++ S+
Sbjct: 1910 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSNAEDTLRSK 1966
Query: 480 NEGHLNPSEKLQKLNEVRKRLNELRELVHYY----EQTSDMMTDAVNE-NRKDEETEESE 534
+ L + + Q E +R E E V E+ + A+ E R + EE+
Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2026
Query: 535 YDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRA 594
E E ++ Q A+ + + A + + + + + +R
Sbjct: 2027 RLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR- 2084
Query: 595 LNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAE 654
GE E E+ EE +AE E L E A+
Sbjct: 2085 --------------GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2130
Query: 655 FEQKINRLMAAKQKLRQL--QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNN 712
+ AA +KLR+ Q+ Q + AA A+ + ++ E T
Sbjct: 2131 ARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT------ 2181
Query: 713 TRGNANKTQKDTGVNEKAREKFYEAKL--QQQQRELKQLQEERKKLIDIQEKIQALQTAC 770
R A Q+ T + + E ++ L ++ QR + E ++ ++E++ +++
Sbjct: 2182 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2241
Query: 771 PDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHE 830
+L A + + +T Q E K V E+++ + R +
Sbjct: 2242 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV--AEEAARLSVAAQEAARLRQ 2299
Query: 831 MLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATW 890
+ E+L Q+R E ++ E + Q + E A + + L Q R ++
Sbjct: 2300 LAEEDLAQQRALAEKMLKE--KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2357
Query: 891 GGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQ-DASSNDNFSVCPSNSVNHNSYNGKET 949
L EE ++G RT E E + Q + S+ ++ +E
Sbjct: 2358 AQQ----LAEE-------TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2406
Query: 950 KNRWKNNCPFSADENYRPLAKTRQ-----QNISMQRQENLRWVSEL-SYVEEKEQWQEQI 1003
R++ ++ +R T++ Q + +QRQ++ L + E E+ +E++
Sbjct: 2407 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2466
Query: 1004 NQLKKQLDFSVSICQTLMQDQ--QTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQC 1061
Q K L QT+ Q+Q Q L Q+ L+ S++ Q + QL
Sbjct: 2467 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--- 2523
Query: 1062 YTQLTWQQNNVQRLKQMLNELMRQQNQ 1088
Q+ V + +Q+ E RQQ Q
Sbjct: 2524 ------FQDEVAKAQQLREEQQRQQQQ 2544
Score = 52.0 bits (123), Expect = 6e-06
Identities = 187/1043 (17%), Positives = 385/1043 (36%), Gaps = 122/1043 (11%)
Query: 14 DQDLPNW---SNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSP 70
+++L W +NE + RL + Q+ A +EK K++ E+ +R ++
Sbjct: 1632 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR------GKAEE 1685
Query: 71 GVGRRRTKTPHTFPHSRYMSQMSVPEQ--AELEKLKQRINFSDLDQ-RSIGSDSQGR--- 124
R+R R +++ + ++ AE E ++ R +Q R + + R
Sbjct: 1686 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1745
Query: 125 -ATAANNKRQ-----LSENRKPFNFLPMQINTNKSKDASTSPPNRETIGS--AQCKELFA 176
A AA KRQ L++ R L + + STS +++ + + + +EL
Sbjct: 1746 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1805
Query: 177 SA-----LSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNE 231
A L+ + + Q++EED + A + +L I + T+ + E + E
Sbjct: 1806 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE-ATRLKTEAE--IALKE 1862
Query: 232 RSANVERLTHLID-------HLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLK 284
+ A ERL L + L+EQ + +++ LA+ + E L++Q L++
Sbjct: 1863 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLVE 1918
Query: 285 RMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELND 344
L+Q+ Q+ + +LAL+ E+A A + L I S + L
Sbjct: 1919 DTLRQRRQV------EEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRS 1965
Query: 345 LIQRFHNQLRDSQPPAVPDNRRQA------ESLSLTREVSQSRKPSASERLPDEKVELFS 398
Q R Q A + RR+ +SL+ E ++ RK +A E + K ++
Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEE 2024
Query: 399 KMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGES 458
R+ + +Q+ + L + L + +V Q+ L + E
Sbjct: 2025 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-------LQQTLQQEQ 2077
Query: 459 NSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMT 518
+ L A+ + E+E E Q +V + L++ Q
Sbjct: 2078 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAEEQAQARAQAQ 2136
Query: 519 DAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTV 578
A + RK+ E E + + + +R Q A E + Q +
Sbjct: 2137 AAAEKLRKEAEQEAARRAQAEQAA-----LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2191
Query: 579 NSNCEIN--------NRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE 630
+ + N ++ L + R + E+E+ + + +E + +A
Sbjct: 2192 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2251
Query: 631 EGVSGASLSSHRSS----LVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQ 686
E + A + + + L +E + + ++ RL A Q+ +L+ L ++D AQ
Sbjct: 2252 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA----EEDLAQ 2307
Query: 687 GVISASASNLDDFYPAEEDT--KQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQR 744
A + +E T K + + Q+ ++ +E+ + ++ Q
Sbjct: 2308 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2367
Query: 745 ELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETS 804
+ L+ ER++ +++ + + L+ ++ + A + A +++ E +
Sbjct: 2368 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2427
Query: 805 TSKSV-------FEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQ--RRQG 855
T + V + + S L + E +E+L+Q K L+ E Q +++
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2487
Query: 856 LAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRT 915
L + + S S+ L + EK Q DE +++
Sbjct: 2488 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE-----QLFQDE-------VAKAQQLR 2535
Query: 916 DEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQN 975
+E++ ++Q V + +E R E + L + R+Q
Sbjct: 2536 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--------KQEELQQLEQQRRQQ 2587
Query: 976 ISMQRQENLRWVSELSYVEEKEQ 998
+ +EN R +L +EE+ +
Sbjct: 2588 EELLAEENQRLREQLQLLEEQHR 2610
Score = 45.8 bits (107), Expect = 4e-04
Identities = 145/779 (18%), Positives = 283/779 (36%), Gaps = 99/779 (12%)
Query: 197 EPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKF 256
EP+ + + S L + + S+ +EK + + V R T + + + +K
Sbjct: 1059 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1118
Query: 257 LKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAV 316
+ + A P+ E + +LKK L + QQ AL+ + + +Q
Sbjct: 1119 AQAVPATLPELEATKA--SLKK---LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1173
Query: 317 MDDSV------VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA---VPDNRRQ 367
D V VA+ V +++ + + + R R+S P + D RR+
Sbjct: 1174 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1233
Query: 368 AESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNN 427
E + P A + E++ + + L E+ ++ + + E Q++N
Sbjct: 1234 QEQIQAM--------PLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINA 1282
Query: 428 SSSSPQRSVDQRSTSAPSASVGLAPVVNGESNS-----------------LTSS-VPYPT 469
+ V ++ P AS P V S S LTS + + +
Sbjct: 1283 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1342
Query: 470 ASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNE--NRKD 527
+L E E +E+ ++L EV L + R+L + Q E R
Sbjct: 1343 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1402
Query: 528 EET---EESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEI 584
EE EE+ D++ + + ++ S A+ + R + +
Sbjct: 1403 EEVVRREEAAVDAQQQKRS---------IQEELQQLRQSSEAEIQAKARQAEAAERS-RL 1452
Query: 585 NNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSS 644
+ L + + R EGE + A+ E+ E ++ +A+EE R
Sbjct: 1453 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQ 1506
Query: 645 LVDEHPEDAEFEQKINRLM-----AAKQKLRQLQDLVAM-VQDDDAAQGVISASASNLDD 698
+ DE + E ++ + AA++K R LQ L + +Q ++A + + A
Sbjct: 1507 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1566
Query: 699 FYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLID 758
A E ++++ A K EK + E LQ++ + QL+EE ++
Sbjct: 1567 VQVALETAQRSA-----EAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREEAERRAQ 1619
Query: 759 IQ-EKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSI 817
Q E +A + A +L+ + + E + KS+ + E
Sbjct: 1620 QQAEAERAREEAERELERWQLKANEALRLR----------LQAEEVAQQKSLAQAEAEKQ 1669
Query: 818 VDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAE---TASPVAVSLRSDGSEN 874
+ RR + + +RQR + L + Q +G A+ A + LR++ +
Sbjct: 1670 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1729
Query: 875 LCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLS------EGIVRTDEEEEEEQDASS 927
Q+ E+ +A A + + + L+ E ++ + EEE ++S
Sbjct: 1730 --EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1786
Score = 43.1 bits (100), Expect = 0.003
Identities = 127/677 (18%), Positives = 251/677 (37%), Gaps = 80/677 (11%)
Query: 218 KASSMREDLVEKNER-SANVERLTHLIDHLKEQEKSYMKFLKKILARDPQ-QEPMEEIEN 275
+A+ R+ +E+ ER A VE L + +++ ++ ++ + Q +E
Sbjct: 2003 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2062
Query: 276 LKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSIT 335
+K+ +L + + Q+Q L L+G A +AE+A + E A S V
Sbjct: 2063 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE----REAAQSRRQVEEA 2118
Query: 336 SELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQS----RKPSASERLPD 391
L + + Q R A R++AE + R ++ +K +A +
Sbjct: 2119 ERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2173
Query: 392 EKVELFSKMRVLQEKKQKMDKLLGELH------TLRDQHLNNSSSSPQRSVDQRSTSAPS 445
K +R + +Q++ L +L L D+ L + + QRS
Sbjct: 2174 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV--E 2231
Query: 446 ASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNP-SEKLQKLNEVRKRLN--- 501
+ V E + L + + +L+ +++ + L +EK++++ E RL+
Sbjct: 2232 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2291
Query: 502 ----ELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTW 557
LR+L + + + + + E + +E E + + Q
Sbjct: 2292 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL- 2350
Query: 558 NEVNSHSNAQCVSNNRDG--RTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHV 615
+ + AQ ++ G RT+ + + +A L + R E
Sbjct: 2351 -QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---------RVAEMSRAQ 2400
Query: 616 AQGEDDEEE-EEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQD 674
A+ E+D + ++AEE G HR+ L + +I R + R +
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEK-----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2455
Query: 675 LVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKF 734
+ + ++ + Q ++ +++ + ++KD+ + RE+F
Sbjct: 2456 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ---RERF 2512
Query: 735 YEAKLQQQQRELKQL-QEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVT 793
E Q++ +L+QL Q+E K ++E+ Q Q ++ + A
Sbjct: 2513 IE----QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ------------ERQRLVASM 2556
Query: 794 STPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRR 853
QHE + E + E E+L EE ++ R+QL+ L E Q R
Sbjct: 2557 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----ELLAEENQRLREQLQLL--EEQHR 2610
Query: 854 QGLAE----TASPVAVS 866
LA TAS VA +
Sbjct: 2611 AALAHSEEVTASQVAAT 2627
Score = 41.2 bits (95), Expect = 0.010
Identities = 176/929 (18%), Positives = 336/929 (36%), Gaps = 106/929 (11%)
Query: 224 EDLVEKNERSANVERLTHLIDHLKEQEK-----SYMKFLKKILARDPQQEPMEEIENLKK 278
E+ + + +R+ ERL + L++Q + + K + A++ QQ EE+ ++
Sbjct: 1351 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1410
Query: 279 QH-DLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSE 337
D ++ QE+L+ L RQ++ +Q KA QA A + E + V + E
Sbjct: 1411 AAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEE--EIRVVRLQLE 1466
Query: 338 LNEELNDLIQRFHNQLRDSQPPAVPDNRR-QAESLSLTREVSQSRKPSASERLPDEKVEL 396
E + LR A R+ Q E+ L R+V S+R +VEL
Sbjct: 1467 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----SQRKRQAEVEL 1521
Query: 397 FSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNG 456
S+++ E ++ + L L LR Q Q V+ R+ A
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRSAEA 1580
Query: 457 ESNSLTSSVPYPTASL----------VSQNESENEGHLNPSEKLQKLNEVRKR------- 499
E S +S TA L V+Q E E + ++ E +R
Sbjct: 1581 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1640
Query: 500 -LNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRN--PQVAST 556
NE L E+ + + A E K +E E E + E R Q
Sbjct: 1641 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1700
Query: 557 WNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAA----NIRALNMPPSLDCRYNREGEQE 612
++ + Q ++ ++ + + E + + L + + +E E E
Sbjct: 1701 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1760
Query: 613 IHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQL 672
+ + E + +A E S ++ + L E E ++ RL A ++ ++
Sbjct: 1761 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1820
Query: 673 QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAR- 731
+ L ++DAA+ A + E T+ + K ++ + A
Sbjct: 1821 RQLA----EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1876
Query: 732 EKFYEAKLQQQ--------QRELKQLQ-------EERKKLID--------IQEKIQALQT 768
E F +L++Q + L QL+ E +K L++ ++E+I AL+
Sbjct: 1877 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1936
Query: 769 ACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRR 828
+ A+ G + + + S N +T SK E E + R+
Sbjct: 1937 S-----FEKAAAGKAELELELGRIRS----NAEDTLRSKEQAELEAA-----------RQ 1976
Query: 829 HEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMA 888
++ EE R+RR+ E + Q+ E A+ + + +++R + A
Sbjct: 1977 RQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2032
Query: 889 TWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKE 948
+ Q L +E + +E +++EQ+ ++ SV E
Sbjct: 2033 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ----TLQQEQSVLDQLRGEAE 2088
Query: 949 TKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKK 1008
R + + R A++R+Q ++ E L+ +E + + Q Q +L+K
Sbjct: 2089 AARRAAEEAEEARVQAEREAAQSRRQ---VEEAERLKQSAE-EQAQARAQAQAAAEKLRK 2144
Query: 1009 QLDFSVS----ICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQ-VHFIMHQLNQCYT 1063
+ + + Q ++ +Q ++ + Q + + QL +
Sbjct: 2145 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2204
Query: 1064 QLTWQQNNVQRLKQMLNELMRQQNQHPEK 1092
Q +QRLK E RQ++Q E+
Sbjct: 2205 QKNLLDEELQRLKAEATEAARQRSQVEEE 2233
Score = 38.9 bits (89), Expect = 0.052
Identities = 105/631 (16%), Positives = 241/631 (38%), Gaps = 60/631 (9%)
Query: 1419 RQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFE 1478
+QRAL AL+++ R +E E+ V + L ++ A + ++ +F
Sbjct: 1535 KQRALQALEEL--RLQAEEAERRLRQAEVERARQV--QVALETAQRSAEAELQSKRASFA 1590
Query: 1479 RETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARM-REYERMKTEAESN 1537
+T ++ ++ +V + E A ++A RE ER + +A
Sbjct: 1591 EKTAQLERSLQEEHVAVAQLREEAERRAQQQA-----EAERAREEAERELERWQLKANEA 1645
Query: 1538 SNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQI 1597
+R + EE E + ++ +E + + Q+L++Q
Sbjct: 1646 LRLRLQAEEVAQQKSLAQAEAEKQKEEA---EREARRRGKAEEQAVRQRELAEQELEKQ- 1701
Query: 1598 KAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSL 1657
+ E + Q L + + ++ L + ++ ++ + ++L + +++
Sbjct: 1702 ------------RQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAA 1748
Query: 1658 AKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEA-TGVIQS 1716
A R ++L E+++V + S + ++ K+++EA G +
Sbjct: 1749 AATQKR------QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1802
Query: 1717 CAKEAKRI--LEDHGSPAGEIDDED--KDKDETETVKQTQTSEVYDGPK-NVRSDISDQE 1771
A+EA R+ L + ++ +ED + + E E V + + + + + ++I+ +E
Sbjct: 1803 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1862
Query: 1772 EDEESEGC-----PVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANT 1826
++ E+E + + E QA + + E ++ + + ++ Q L +T
Sbjct: 1863 KEAENERLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSELERQKGLVEDT 1920
Query: 1827 -EATEENEHDEQVLQRDFKKTAESK---NVPLEREATSKND----QNNCPVKPCYLNIL- 1877
+ E + L+ F+K A K + L R ++ D + ++ L
Sbjct: 1921 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1980
Query: 1878 -EDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAG-- 1934
E+E+ A + + L E+E L +V+E + +E E A
Sbjct: 1981 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2040
Query: 1935 --SPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKN 1992
+ + L + +A + + QK E ++ + + EA+ ++ EE ++
Sbjct: 2041 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2100
Query: 1993 HLSGEICEMQTEELAGNSETLKEPETVGAQS 2023
+ E Q+ +E LK+ AQ+
Sbjct: 2101 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2131
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 57.8 bits (138), Expect = 1e-07
Identities = 199/1107 (17%), Positives = 394/1107 (35%), Gaps = 107/1107 (9%)
Query: 36 AQQKKANRSSEKNKKKFGVESDKRVTNDISPES----SPGVGRRRTKTPHTFPHSRYMSQ 91
AQ+++A +E+ +++ ES ++ ++ S R + + R ++
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546
Query: 92 MSVPE--QAELEKLKQRINFSDLDQRSIGSDSQG-RATAANNKRQLSENRKPFNFLPMQI 148
+ QAE+E+ +Q + QRS ++ Q RA+ A QL + + + Q+
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 149 NTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSR 208
+ A A+ +EL L + ++ E+ + ++ ++ +
Sbjct: 1607 REEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665
Query: 209 LVQIRDYITKASSMREDLVEKNERSAN-VERLTHLIDHLKEQEKSYMKFLKKILARDPQQ 267
+ + E V + E + +E+ L + +Q + + L ++ A Q
Sbjct: 1666 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 268 EPM-----EEIENLKKQHDLLKRMLQQQE-QLRALQGRQAALLALQHKAEQAIAVMDDSV 321
E EE+ L+++ + Q+ E +L ++ LLA + +AE+ +
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 322 VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRR-------------QA 368
+E L L + Q + ++ A +A
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1845
Query: 369 ESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEK----KQKMDKLLGELHTLRDQH 424
L E++ K + +ERL + + R L+E+ K +++ L +L D
Sbjct: 1846 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1905
Query: 425 LNNSSSSPQRSVDQR-----STSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESE 479
L + ++ QR A AS A E L + ++ S+
Sbjct: 1906 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSNAEDTLRSK 1962
Query: 480 NEGHLNPSEKLQKLNEVRKRLNELRELVHYY----EQTSDMMTDAVNE-NRKDEETEESE 534
+ L + + Q E +R E E V E+ + A+ E R + EE+
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2022
Query: 535 YDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRA 594
E E ++ Q A+ + + A + + + + + +R
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR- 2080
Query: 595 LNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAE 654
GE E E+ EE +AE E L E A+
Sbjct: 2081 --------------GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126
Query: 655 FEQKINRLMAAKQKLRQL--QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNN 712
+ AA +KLR+ Q+ Q + AA A+ + ++ E T
Sbjct: 2127 ARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT------ 2177
Query: 713 TRGNANKTQKDTGVNEKAREKFYEAKL--QQQQRELKQLQEERKKLIDIQEKIQALQTAC 770
R A Q+ T + + E ++ L ++ QR + E ++ ++E++ +++
Sbjct: 2178 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2237
Query: 771 PDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHE 830
+L A + + +T Q E K V E+++ + R +
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV--AEEAARLSVAAQEAARLRQ 2295
Query: 831 MLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATW 890
+ E+L Q+R E ++ E + Q + E A + + L Q R ++
Sbjct: 2296 LAEEDLAQQRALAEKMLKE--KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353
Query: 891 GGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQ-DASSNDNFSVCPSNSVNHNSYNGKET 949
L EE ++G RT E E + Q + S+ ++ +E
Sbjct: 2354 AQQ----LAEE-------TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2402
Query: 950 KNRWKNNCPFSADENYRPLAKTRQ-----QNISMQRQENLRWVSEL-SYVEEKEQWQEQI 1003
R++ ++ +R T++ Q + +QRQ++ L + E E+ +E++
Sbjct: 2403 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2462
Query: 1004 NQLKKQLDFSVSICQTLMQDQ--QTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQC 1061
Q K L QT+ Q+Q Q L Q+ L+ S++ Q + QL
Sbjct: 2463 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--- 2519
Query: 1062 YTQLTWQQNNVQRLKQMLNELMRQQNQ 1088
Q+ V + +Q+ E RQQ Q
Sbjct: 2520 ------FQDEVAKAQQLREEQQRQQQQ 2540
Score = 52.0 bits (123), Expect = 6e-06
Identities = 187/1043 (17%), Positives = 385/1043 (36%), Gaps = 122/1043 (11%)
Query: 14 DQDLPNW---SNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSP 70
+++L W +NE + RL + Q+ A +EK K++ E+ +R ++
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR------GKAEE 1681
Query: 71 GVGRRRTKTPHTFPHSRYMSQMSVPEQ--AELEKLKQRINFSDLDQ-RSIGSDSQGR--- 124
R+R R +++ + ++ AE E ++ R +Q R + + R
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1741
Query: 125 -ATAANNKRQ-----LSENRKPFNFLPMQINTNKSKDASTSPPNRETIGS--AQCKELFA 176
A AA KRQ L++ R L + + STS +++ + + + +EL
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Query: 177 SA-----LSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNE 231
A L+ + + Q++EED + A + +L I + T+ + E + E
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE-ATRLKTEAE--IALKE 1858
Query: 232 RSANVERLTHLID-------HLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLK 284
+ A ERL L + L+EQ + +++ LA+ + E L++Q L++
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLVE 1914
Query: 285 RMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELND 344
L+Q+ Q+ + +LAL+ E+A A + L I S + L
Sbjct: 1915 DTLRQRRQV------EEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRS 1961
Query: 345 LIQRFHNQLRDSQPPAVPDNRRQA------ESLSLTREVSQSRKPSASERLPDEKVELFS 398
Q R Q A + RR+ +SL+ E ++ RK +A E + K ++
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEE 2020
Query: 399 KMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGES 458
R+ + +Q+ + L + L + +V Q+ L + E
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-------LQQTLQQEQ 2073
Query: 459 NSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMT 518
+ L A+ + E+E E Q +V + L++ Q
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAEEQAQARAQAQ 2132
Query: 519 DAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTV 578
A + RK+ E E + + + +R Q A E + Q +
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAA-----LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Query: 579 NSNCEIN--------NRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE 630
+ + N ++ L + R + E+E+ + + +E + +A
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2247
Query: 631 EGVSGASLSSHRSS----LVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQ 686
E + A + + + L +E + + ++ RL A Q+ +L+ L ++D AQ
Sbjct: 2248 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA----EEDLAQ 2303
Query: 687 GVISASASNLDDFYPAEEDT--KQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQR 744
A + +E T K + + Q+ ++ +E+ + ++ Q
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363
Query: 745 ELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETS 804
+ L+ ER++ +++ + + L+ ++ + A + A +++ E +
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 805 TSKSV-------FEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQ--RRQG 855
T + V + + S L + E +E+L+Q K L+ E Q +++
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483
Query: 856 LAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRT 915
L + + S S+ L + EK Q DE +++
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE-----QLFQDE-------VAKAQQLR 2531
Query: 916 DEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQN 975
+E++ ++Q V + +E R E + L + R+Q
Sbjct: 2532 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--------KQEELQQLEQQRRQQ 2583
Query: 976 ISMQRQENLRWVSELSYVEEKEQ 998
+ +EN R +L +EE+ +
Sbjct: 2584 EELLAEENQRLREQLQLLEEQHR 2606
Score = 45.8 bits (107), Expect = 4e-04
Identities = 145/779 (18%), Positives = 283/779 (36%), Gaps = 99/779 (12%)
Query: 197 EPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKF 256
EP+ + + S L + + S+ +EK + + V R T + + + +K
Sbjct: 1055 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1114
Query: 257 LKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAV 316
+ + A P+ E + +LKK L + QQ AL+ + + +Q
Sbjct: 1115 AQAVPATLPELEATKA--SLKK---LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1169
Query: 317 MDDSV------VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA---VPDNRRQ 367
D V VA+ V +++ + + + R R+S P + D RR+
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1229
Query: 368 AESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNN 427
E + P A + E++ + + L E+ ++ + + E Q++N
Sbjct: 1230 QEQIQAM--------PLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINA 1278
Query: 428 SSSSPQRSVDQRSTSAPSASVGLAPVVNGESNS-----------------LTSS-VPYPT 469
+ V ++ P AS P V S S LTS + + +
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338
Query: 470 ASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNE--NRKD 527
+L E E +E+ ++L EV L + R+L + Q E R
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 528 EET---EESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEI 584
EE EE+ D++ + + ++ S A+ + R + +
Sbjct: 1399 EEVVRREEAAVDAQQQKRS---------IQEELQQLRQSSEAEIQAKARQAEAAERS-RL 1448
Query: 585 NNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSS 644
+ L + + R EGE + A+ E+ E ++ +A+EE R
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQ 1502
Query: 645 LVDEHPEDAEFEQKINRLM-----AAKQKLRQLQDLVAM-VQDDDAAQGVISASASNLDD 698
+ DE + E ++ + AA++K R LQ L + +Q ++A + + A
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562
Query: 699 FYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLID 758
A E ++++ A K EK + E LQ++ + QL+EE ++
Sbjct: 1563 VQVALETAQRSA-----EAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREEAERRAQ 1615
Query: 759 IQ-EKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSI 817
Q E +A + A +L+ + + E + KS+ + E
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLR----------LQAEEVAQQKSLAQAEAEKQ 1665
Query: 818 VDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAE---TASPVAVSLRSDGSEN 874
+ RR + + +RQR + L + Q +G A+ A + LR++ +
Sbjct: 1666 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 875 LCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLS------EGIVRTDEEEEEEQDASS 927
Q+ E+ +A A + + + L+ E ++ + EEE ++S
Sbjct: 1726 --EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782
Score = 43.1 bits (100), Expect = 0.003
Identities = 127/677 (18%), Positives = 251/677 (37%), Gaps = 80/677 (11%)
Query: 218 KASSMREDLVEKNER-SANVERLTHLIDHLKEQEKSYMKFLKKILARDPQ-QEPMEEIEN 275
+A+ R+ +E+ ER A VE L + +++ ++ ++ + Q +E
Sbjct: 1999 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2058
Query: 276 LKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSIT 335
+K+ +L + + Q+Q L L+G A +AE+A + E A S V
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE----REAAQSRRQVEEA 2114
Query: 336 SELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQS----RKPSASERLPD 391
L + + Q R A R++AE + R ++ +K +A +
Sbjct: 2115 ERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2169
Query: 392 EKVELFSKMRVLQEKKQKMDKLLGELH------TLRDQHLNNSSSSPQRSVDQRSTSAPS 445
K +R + +Q++ L +L L D+ L + + QRS
Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV--E 2227
Query: 446 ASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNP-SEKLQKLNEVRKRLN--- 501
+ V E + L + + +L+ +++ + L +EK++++ E RL+
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 502 ----ELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTW 557
LR+L + + + + + E + +E E + + Q
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL- 2346
Query: 558 NEVNSHSNAQCVSNNRDG--RTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHV 615
+ + AQ ++ G RT+ + + +A L + R E
Sbjct: 2347 -QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---------RVAEMSRAQ 2396
Query: 616 AQGEDDEEE-EEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQD 674
A+ E+D + ++AEE G HR+ L + +I R + R +
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEK-----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2451
Query: 675 LVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKF 734
+ + ++ + Q ++ +++ + ++KD+ + RE+F
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ---RERF 2508
Query: 735 YEAKLQQQQRELKQL-QEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVT 793
E Q++ +L+QL Q+E K ++E+ Q Q ++ + A
Sbjct: 2509 IE----QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ------------ERQRLVASM 2552
Query: 794 STPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRR 853
QHE + E + E E+L EE ++ R+QL+ L E Q R
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----ELLAEENQRLREQLQLL--EEQHR 2606
Query: 854 QGLAE----TASPVAVS 866
LA TAS VA +
Sbjct: 2607 AALAHSEEVTASQVAAT 2623
Score = 41.2 bits (95), Expect = 0.010
Identities = 176/929 (18%), Positives = 336/929 (36%), Gaps = 106/929 (11%)
Query: 224 EDLVEKNERSANVERLTHLIDHLKEQEK-----SYMKFLKKILARDPQQEPMEEIENLKK 278
E+ + + +R+ ERL + L++Q + + K + A++ QQ EE+ ++
Sbjct: 1347 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406
Query: 279 QH-DLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSE 337
D ++ QE+L+ L RQ++ +Q KA QA A + E + V + E
Sbjct: 1407 AAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEE--EIRVVRLQLE 1462
Query: 338 LNEELNDLIQRFHNQLRDSQPPAVPDNRR-QAESLSLTREVSQSRKPSASERLPDEKVEL 396
E + LR A R+ Q E+ L R+V S+R +VEL
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----SQRKRQAEVEL 1517
Query: 397 FSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNG 456
S+++ E ++ + L L LR Q Q V+ R+ A
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRSAEA 1576
Query: 457 ESNSLTSSVPYPTASL----------VSQNESENEGHLNPSEKLQKLNEVRKR------- 499
E S +S TA L V+Q E E + ++ E +R
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1636
Query: 500 -LNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRN--PQVAST 556
NE L E+ + + A E K +E E E + E R Q
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1696
Query: 557 WNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAA----NIRALNMPPSLDCRYNREGEQE 612
++ + Q ++ ++ + + E + + L + + +E E E
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1756
Query: 613 IHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQL 672
+ + E + +A E S ++ + L E E ++ RL A ++ ++
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816
Query: 673 QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAR- 731
+ L ++DAA+ A + E T+ + K ++ + A
Sbjct: 1817 RQLA----EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1872
Query: 732 EKFYEAKLQQQ--------QRELKQLQ-------EERKKLID--------IQEKIQALQT 768
E F +L++Q + L QL+ E +K L++ ++E+I AL+
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1932
Query: 769 ACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRR 828
+ A+ G + + + S N +T SK E E + R+
Sbjct: 1933 S-----FEKAAAGKAELELELGRIRS----NAEDTLRSKEQAELEAA-----------RQ 1972
Query: 829 HEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMA 888
++ EE R+RR+ E + Q+ E A+ + + +++R + A
Sbjct: 1973 RQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2028
Query: 889 TWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKE 948
+ Q L +E + +E +++EQ+ ++ SV E
Sbjct: 2029 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ----TLQQEQSVLDQLRGEAE 2084
Query: 949 TKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKK 1008
R + + R A++R+Q ++ E L+ +E + + Q Q +L+K
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQ---VEEAERLKQSAE-EQAQARAQAQAAAEKLRK 2140
Query: 1009 QLDFSVS----ICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQ-VHFIMHQLNQCYT 1063
+ + + Q ++ +Q ++ + Q + + QL +
Sbjct: 2141 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2200
Query: 1064 QLTWQQNNVQRLKQMLNELMRQQNQHPEK 1092
Q +QRLK E RQ++Q E+
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEE 2229
Score = 38.9 bits (89), Expect = 0.052
Identities = 105/631 (16%), Positives = 241/631 (38%), Gaps = 60/631 (9%)
Query: 1419 RQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFE 1478
+QRAL AL+++ R +E E+ V + L ++ A + ++ +F
Sbjct: 1531 KQRALQALEEL--RLQAEEAERRLRQAEVERARQV--QVALETAQRSAEAELQSKRASFA 1586
Query: 1479 RETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARM-REYERMKTEAESN 1537
+T ++ ++ +V + E A ++A RE ER + +A
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQA-----EAERAREEAERELERWQLKANEA 1641
Query: 1538 SNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQI 1597
+R + EE E + ++ +E + + Q+L++Q
Sbjct: 1642 LRLRLQAEEVAQQKSLAQAEAEKQKEEA---EREARRRGKAEEQAVRQRELAEQELEKQ- 1697
Query: 1598 KAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSL 1657
+ E + Q L + + ++ L + ++ ++ + ++L + +++
Sbjct: 1698 ------------RQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAA 1744
Query: 1658 AKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEA-TGVIQS 1716
A R ++L E+++V + S + ++ K+++EA G +
Sbjct: 1745 AATQKR------QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798
Query: 1717 CAKEAKRI--LEDHGSPAGEIDDED--KDKDETETVKQTQTSEVYDGPK-NVRSDISDQE 1771
A+EA R+ L + ++ +ED + + E E V + + + + + ++I+ +E
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858
Query: 1772 EDEESEGC-----PVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANT 1826
++ E+E + + E QA + + E ++ + + ++ Q L +T
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSELERQKGLVEDT 1916
Query: 1827 -EATEENEHDEQVLQRDFKKTAESK---NVPLEREATSKND----QNNCPVKPCYLNIL- 1877
+ E + L+ F+K A K + L R ++ D + ++ L
Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 1878 -EDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAG-- 1934
E+E+ A + + L E+E L +V+E + +E E A
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036
Query: 1935 --SPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKN 1992
+ + L + +A + + QK E ++ + + EA+ ++ EE ++
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096
Query: 1993 HLSGEICEMQTEELAGNSETLKEPETVGAQS 2023
+ E Q+ +E LK+ AQ+
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 57.8 bits (138), Expect = 1e-07
Identities = 199/1107 (17%), Positives = 394/1107 (35%), Gaps = 107/1107 (9%)
Query: 36 AQQKKANRSSEKNKKKFGVESDKRVTNDISPES----SPGVGRRRTKTPHTFPHSRYMSQ 91
AQ+++A +E+ +++ ES ++ ++ S R + + R ++
Sbjct: 1455 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1514
Query: 92 MSVPE--QAELEKLKQRINFSDLDQRSIGSDSQG-RATAANNKRQLSENRKPFNFLPMQI 148
+ QAE+E+ +Q + QRS ++ Q RA+ A QL + + + Q+
Sbjct: 1515 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1574
Query: 149 NTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSR 208
+ A A+ +EL L + ++ E+ + ++ ++ +
Sbjct: 1575 REEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1633
Query: 209 LVQIRDYITKASSMREDLVEKNERSAN-VERLTHLIDHLKEQEKSYMKFLKKILARDPQQ 267
+ + E V + E + +E+ L + +Q + + L ++ A Q
Sbjct: 1634 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1693
Query: 268 EPM-----EEIENLKKQHDLLKRMLQQQE-QLRALQGRQAALLALQHKAEQAIAVMDDSV 321
E EE+ L+++ + Q+ E +L ++ LLA + +AE+ +
Sbjct: 1694 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1753
Query: 322 VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRR-------------QA 368
+E L L + Q + ++ A +A
Sbjct: 1754 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1813
Query: 369 ESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEK----KQKMDKLLGELHTLRDQH 424
L E++ K + +ERL + + R L+E+ K +++ L +L D
Sbjct: 1814 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1873
Query: 425 LNNSSSSPQRSVDQR-----STSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESE 479
L + ++ QR A AS A E L + ++ S+
Sbjct: 1874 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSNAEDTLRSK 1930
Query: 480 NEGHLNPSEKLQKLNEVRKRLNELRELVHYY----EQTSDMMTDAVNE-NRKDEETEESE 534
+ L + + Q E +R E E V E+ + A+ E R + EE+
Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 1990
Query: 535 YDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRA 594
E E ++ Q A+ + + A + + + + + +R
Sbjct: 1991 RLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR- 2048
Query: 595 LNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAE 654
GE E E+ EE +AE E L E A+
Sbjct: 2049 --------------GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2094
Query: 655 FEQKINRLMAAKQKLRQL--QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNN 712
+ AA +KLR+ Q+ Q + AA A+ + ++ E T
Sbjct: 2095 ARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT------ 2145
Query: 713 TRGNANKTQKDTGVNEKAREKFYEAKL--QQQQRELKQLQEERKKLIDIQEKIQALQTAC 770
R A Q+ T + + E ++ L ++ QR + E ++ ++E++ +++
Sbjct: 2146 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2205
Query: 771 PDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHE 830
+L A + + +T Q E K V E+++ + R +
Sbjct: 2206 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV--AEEAARLSVAAQEAARLRQ 2263
Query: 831 MLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATW 890
+ E+L Q+R E ++ E + Q + E A + + L Q R ++
Sbjct: 2264 LAEEDLAQQRALAEKMLKE--KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2321
Query: 891 GGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQ-DASSNDNFSVCPSNSVNHNSYNGKET 949
L EE ++G RT E E + Q + S+ ++ +E
Sbjct: 2322 AQQ----LAEE-------TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2370
Query: 950 KNRWKNNCPFSADENYRPLAKTRQ-----QNISMQRQENLRWVSEL-SYVEEKEQWQEQI 1003
R++ ++ +R T++ Q + +QRQ++ L + E E+ +E++
Sbjct: 2371 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2430
Query: 1004 NQLKKQLDFSVSICQTLMQDQ--QTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQC 1061
Q K L QT+ Q+Q Q L Q+ L+ S++ Q + QL
Sbjct: 2431 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--- 2487
Query: 1062 YTQLTWQQNNVQRLKQMLNELMRQQNQ 1088
Q+ V + +Q+ E RQQ Q
Sbjct: 2488 ------FQDEVAKAQQLREEQQRQQQQ 2508
Score = 52.0 bits (123), Expect = 6e-06
Identities = 187/1043 (17%), Positives = 385/1043 (36%), Gaps = 122/1043 (11%)
Query: 14 DQDLPNW---SNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSP 70
+++L W +NE + RL + Q+ A +EK K++ E+ +R ++
Sbjct: 1596 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR------GKAEE 1649
Query: 71 GVGRRRTKTPHTFPHSRYMSQMSVPEQ--AELEKLKQRINFSDLDQ-RSIGSDSQGR--- 124
R+R R +++ + ++ AE E ++ R +Q R + + R
Sbjct: 1650 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1709
Query: 125 -ATAANNKRQ-----LSENRKPFNFLPMQINTNKSKDASTSPPNRETIGS--AQCKELFA 176
A AA KRQ L++ R L + + STS +++ + + + +EL
Sbjct: 1710 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1769
Query: 177 SA-----LSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNE 231
A L+ + + Q++EED + A + +L I + T+ + E + E
Sbjct: 1770 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE-ATRLKTEAE--IALKE 1826
Query: 232 RSANVERLTHLID-------HLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLK 284
+ A ERL L + L+EQ + +++ LA+ + E L++Q L++
Sbjct: 1827 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLVE 1882
Query: 285 RMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELND 344
L+Q+ Q+ + +LAL+ E+A A + L I S + L
Sbjct: 1883 DTLRQRRQV------EEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRS 1929
Query: 345 LIQRFHNQLRDSQPPAVPDNRRQA------ESLSLTREVSQSRKPSASERLPDEKVELFS 398
Q R Q A + RR+ +SL+ E ++ RK +A E + K ++
Sbjct: 1930 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEE 1988
Query: 399 KMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGES 458
R+ + +Q+ + L + L + +V Q+ L + E
Sbjct: 1989 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-------LQQTLQQEQ 2041
Query: 459 NSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMT 518
+ L A+ + E+E E Q +V + L++ Q
Sbjct: 2042 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAEEQAQARAQAQ 2100
Query: 519 DAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTV 578
A + RK+ E E + + + +R Q A E + Q +
Sbjct: 2101 AAAEKLRKEAEQEAARRAQAEQAA-----LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2155
Query: 579 NSNCEIN--------NRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE 630
+ + N ++ L + R + E+E+ + + +E + +A
Sbjct: 2156 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2215
Query: 631 EGVSGASLSSHRSS----LVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQ 686
E + A + + + L +E + + ++ RL A Q+ +L+ L ++D AQ
Sbjct: 2216 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA----EEDLAQ 2271
Query: 687 GVISASASNLDDFYPAEEDT--KQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQR 744
A + +E T K + + Q+ ++ +E+ + ++ Q
Sbjct: 2272 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2331
Query: 745 ELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETS 804
+ L+ ER++ +++ + + L+ ++ + A + A +++ E +
Sbjct: 2332 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2391
Query: 805 TSKSV-------FEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQ--RRQG 855
T + V + + S L + E +E+L+Q K L+ E Q +++
Sbjct: 2392 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2451
Query: 856 LAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRT 915
L + + S S+ L + EK Q DE +++
Sbjct: 2452 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE-----QLFQDE-------VAKAQQLR 2499
Query: 916 DEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQN 975
+E++ ++Q V + +E R E + L + R+Q
Sbjct: 2500 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--------KQEELQQLEQQRRQQ 2551
Query: 976 ISMQRQENLRWVSELSYVEEKEQ 998
+ +EN R +L +EE+ +
Sbjct: 2552 EELLAEENQRLREQLQLLEEQHR 2574
Score = 45.8 bits (107), Expect = 4e-04
Identities = 145/779 (18%), Positives = 283/779 (36%), Gaps = 99/779 (12%)
Query: 197 EPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKF 256
EP+ + + S L + + S+ +EK + + V R T + + + +K
Sbjct: 1023 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1082
Query: 257 LKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAV 316
+ + A P+ E + +LKK L + QQ AL+ + + +Q
Sbjct: 1083 AQAVPATLPELEATKA--SLKK---LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1137
Query: 317 MDDSV------VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA---VPDNRRQ 367
D V VA+ V +++ + + + R R+S P + D RR+
Sbjct: 1138 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1197
Query: 368 AESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNN 427
E + P A + E++ + + L E+ ++ + + E Q++N
Sbjct: 1198 QEQIQAM--------PLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINA 1246
Query: 428 SSSSPQRSVDQRSTSAPSASVGLAPVVNGESNS-----------------LTSS-VPYPT 469
+ V ++ P AS P V S S LTS + + +
Sbjct: 1247 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1306
Query: 470 ASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNE--NRKD 527
+L E E +E+ ++L EV L + R+L + Q E R
Sbjct: 1307 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1366
Query: 528 EET---EESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEI 584
EE EE+ D++ + + ++ S A+ + R + +
Sbjct: 1367 EEVVRREEAAVDAQQQKRS---------IQEELQQLRQSSEAEIQAKARQAEAAERS-RL 1416
Query: 585 NNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSS 644
+ L + + R EGE + A+ E+ E ++ +A+EE R
Sbjct: 1417 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQ 1470
Query: 645 LVDEHPEDAEFEQKINRLM-----AAKQKLRQLQDLVAM-VQDDDAAQGVISASASNLDD 698
+ DE + E ++ + AA++K R LQ L + +Q ++A + + A
Sbjct: 1471 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1530
Query: 699 FYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLID 758
A E ++++ A K EK + E LQ++ + QL+EE ++
Sbjct: 1531 VQVALETAQRSA-----EAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREEAERRAQ 1583
Query: 759 IQ-EKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSI 817
Q E +A + A +L+ + + E + KS+ + E
Sbjct: 1584 QQAEAERAREEAERELERWQLKANEALRLR----------LQAEEVAQQKSLAQAEAEKQ 1633
Query: 818 VDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAE---TASPVAVSLRSDGSEN 874
+ RR + + +RQR + L + Q +G A+ A + LR++ +
Sbjct: 1634 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1693
Query: 875 LCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLS------EGIVRTDEEEEEEQDASS 927
Q+ E+ +A A + + + L+ E ++ + EEE ++S
Sbjct: 1694 --EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1750
Score = 43.1 bits (100), Expect = 0.003
Identities = 127/677 (18%), Positives = 251/677 (37%), Gaps = 80/677 (11%)
Query: 218 KASSMREDLVEKNER-SANVERLTHLIDHLKEQEKSYMKFLKKILARDPQ-QEPMEEIEN 275
+A+ R+ +E+ ER A VE L + +++ ++ ++ + Q +E
Sbjct: 1967 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2026
Query: 276 LKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSIT 335
+K+ +L + + Q+Q L L+G A +AE+A + E A S V
Sbjct: 2027 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE----REAAQSRRQVEEA 2082
Query: 336 SELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQS----RKPSASERLPD 391
L + + Q R A R++AE + R ++ +K +A +
Sbjct: 2083 ERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2137
Query: 392 EKVELFSKMRVLQEKKQKMDKLLGELH------TLRDQHLNNSSSSPQRSVDQRSTSAPS 445
K +R + +Q++ L +L L D+ L + + QRS
Sbjct: 2138 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV--E 2195
Query: 446 ASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNP-SEKLQKLNEVRKRLN--- 501
+ V E + L + + +L+ +++ + L +EK++++ E RL+
Sbjct: 2196 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2255
Query: 502 ----ELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTW 557
LR+L + + + + + E + +E E + + Q
Sbjct: 2256 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL- 2314
Query: 558 NEVNSHSNAQCVSNNRDG--RTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHV 615
+ + AQ ++ G RT+ + + +A L + R E
Sbjct: 2315 -QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---------RVAEMSRAQ 2364
Query: 616 AQGEDDEEE-EEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQD 674
A+ E+D + ++AEE G HR+ L + +I R + R +
Sbjct: 2365 ARAEEDAQRFRKQAEEIGEK-----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2419
Query: 675 LVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKF 734
+ + ++ + Q ++ +++ + ++KD+ + RE+F
Sbjct: 2420 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ---RERF 2476
Query: 735 YEAKLQQQQRELKQL-QEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVT 793
E Q++ +L+QL Q+E K ++E+ Q Q ++ + A
Sbjct: 2477 IE----QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ------------ERQRLVASM 2520
Query: 794 STPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRR 853
QHE + E + E E+L EE ++ R+QL+ L E Q R
Sbjct: 2521 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----ELLAEENQRLREQLQLL--EEQHR 2574
Query: 854 QGLAE----TASPVAVS 866
LA TAS VA +
Sbjct: 2575 AALAHSEEVTASQVAAT 2591
Score = 41.2 bits (95), Expect = 0.010
Identities = 176/929 (18%), Positives = 336/929 (36%), Gaps = 106/929 (11%)
Query: 224 EDLVEKNERSANVERLTHLIDHLKEQEK-----SYMKFLKKILARDPQQEPMEEIENLKK 278
E+ + + +R+ ERL + L++Q + + K + A++ QQ EE+ ++
Sbjct: 1315 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1374
Query: 279 QH-DLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSE 337
D ++ QE+L+ L RQ++ +Q KA QA A + E + V + E
Sbjct: 1375 AAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEE--EIRVVRLQLE 1430
Query: 338 LNEELNDLIQRFHNQLRDSQPPAVPDNRR-QAESLSLTREVSQSRKPSASERLPDEKVEL 396
E + LR A R+ Q E+ L R+V S+R +VEL
Sbjct: 1431 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----SQRKRQAEVEL 1485
Query: 397 FSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNG 456
S+++ E ++ + L L LR Q Q V+ R+ A
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRSAEA 1544
Query: 457 ESNSLTSSVPYPTASL----------VSQNESENEGHLNPSEKLQKLNEVRKR------- 499
E S +S TA L V+Q E E + ++ E +R
Sbjct: 1545 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1604
Query: 500 -LNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRN--PQVAST 556
NE L E+ + + A E K +E E E + E R Q
Sbjct: 1605 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1664
Query: 557 WNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAA----NIRALNMPPSLDCRYNREGEQE 612
++ + Q ++ ++ + + E + + L + + +E E E
Sbjct: 1665 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1724
Query: 613 IHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQL 672
+ + E + +A E S ++ + L E E ++ RL A ++ ++
Sbjct: 1725 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1784
Query: 673 QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAR- 731
+ L ++DAA+ A + E T+ + K ++ + A
Sbjct: 1785 RQLA----EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1840
Query: 732 EKFYEAKLQQQ--------QRELKQLQ-------EERKKLID--------IQEKIQALQT 768
E F +L++Q + L QL+ E +K L++ ++E+I AL+
Sbjct: 1841 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1900
Query: 769 ACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRR 828
+ A+ G + + + S N +T SK E E + R+
Sbjct: 1901 S-----FEKAAAGKAELELELGRIRS----NAEDTLRSKEQAELEAA-----------RQ 1940
Query: 829 HEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMA 888
++ EE R+RR+ E + Q+ E A+ + + +++R + A
Sbjct: 1941 RQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 1996
Query: 889 TWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKE 948
+ Q L +E + +E +++EQ+ ++ SV E
Sbjct: 1997 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ----TLQQEQSVLDQLRGEAE 2052
Query: 949 TKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKK 1008
R + + R A++R+Q ++ E L+ +E + + Q Q +L+K
Sbjct: 2053 AARRAAEEAEEARVQAEREAAQSRRQ---VEEAERLKQSAE-EQAQARAQAQAAAEKLRK 2108
Query: 1009 QLDFSVS----ICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQ-VHFIMHQLNQCYT 1063
+ + + Q ++ +Q ++ + Q + + QL +
Sbjct: 2109 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2168
Query: 1064 QLTWQQNNVQRLKQMLNELMRQQNQHPEK 1092
Q +QRLK E RQ++Q E+
Sbjct: 2169 QKNLLDEELQRLKAEATEAARQRSQVEEE 2197
Score = 38.9 bits (89), Expect = 0.052
Identities = 105/631 (16%), Positives = 241/631 (38%), Gaps = 60/631 (9%)
Query: 1419 RQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFE 1478
+QRAL AL+++ R +E E+ V + L ++ A + ++ +F
Sbjct: 1499 KQRALQALEEL--RLQAEEAERRLRQAEVERARQV--QVALETAQRSAEAELQSKRASFA 1554
Query: 1479 RETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARM-REYERMKTEAESN 1537
+T ++ ++ +V + E A ++A RE ER + +A
Sbjct: 1555 EKTAQLERSLQEEHVAVAQLREEAERRAQQQA-----EAERAREEAERELERWQLKANEA 1609
Query: 1538 SNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQI 1597
+R + EE E + ++ +E + + Q+L++Q
Sbjct: 1610 LRLRLQAEEVAQQKSLAQAEAEKQKEEA---EREARRRGKAEEQAVRQRELAEQELEKQ- 1665
Query: 1598 KAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSL 1657
+ E + Q L + + ++ L + ++ ++ + ++L + +++
Sbjct: 1666 ------------RQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAA 1712
Query: 1658 AKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEA-TGVIQS 1716
A R ++L E+++V + S + ++ K+++EA G +
Sbjct: 1713 AATQKR------QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1766
Query: 1717 CAKEAKRI--LEDHGSPAGEIDDED--KDKDETETVKQTQTSEVYDGPK-NVRSDISDQE 1771
A+EA R+ L + ++ +ED + + E E V + + + + + ++I+ +E
Sbjct: 1767 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1826
Query: 1772 EDEESEGC-----PVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANT 1826
++ E+E + + E QA + + E ++ + + ++ Q L +T
Sbjct: 1827 KEAENERLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSELERQKGLVEDT 1884
Query: 1827 -EATEENEHDEQVLQRDFKKTAESK---NVPLEREATSKND----QNNCPVKPCYLNIL- 1877
+ E + L+ F+K A K + L R ++ D + ++ L
Sbjct: 1885 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1944
Query: 1878 -EDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAG-- 1934
E+E+ A + + L E+E L +V+E + +E E A
Sbjct: 1945 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2004
Query: 1935 --SPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKN 1992
+ + L + +A + + QK E ++ + + EA+ ++ EE ++
Sbjct: 2005 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2064
Query: 1993 HLSGEICEMQTEELAGNSETLKEPETVGAQS 2023
+ E Q+ +E LK+ AQ+
Sbjct: 2065 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2095
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 57.8 bits (138), Expect = 1e-07
Identities = 199/1107 (17%), Positives = 394/1107 (35%), Gaps = 107/1107 (9%)
Query: 36 AQQKKANRSSEKNKKKFGVESDKRVTNDISPES----SPGVGRRRTKTPHTFPHSRYMSQ 91
AQ+++A +E+ +++ ES ++ ++ S R + + R ++
Sbjct: 1624 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1683
Query: 92 MSVPE--QAELEKLKQRINFSDLDQRSIGSDSQG-RATAANNKRQLSENRKPFNFLPMQI 148
+ QAE+E+ +Q + QRS ++ Q RA+ A QL + + + Q+
Sbjct: 1684 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1743
Query: 149 NTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSR 208
+ A A+ +EL L + ++ E+ + ++ ++ +
Sbjct: 1744 REEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1802
Query: 209 LVQIRDYITKASSMREDLVEKNERSAN-VERLTHLIDHLKEQEKSYMKFLKKILARDPQQ 267
+ + E V + E + +E+ L + +Q + + L ++ A Q
Sbjct: 1803 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1862
Query: 268 EPM-----EEIENLKKQHDLLKRMLQQQE-QLRALQGRQAALLALQHKAEQAIAVMDDSV 321
E EE+ L+++ + Q+ E +L ++ LLA + +AE+ +
Sbjct: 1863 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1922
Query: 322 VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRR-------------QA 368
+E L L + Q + ++ A +A
Sbjct: 1923 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1982
Query: 369 ESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEK----KQKMDKLLGELHTLRDQH 424
L E++ K + +ERL + + R L+E+ K +++ L +L D
Sbjct: 1983 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 2042
Query: 425 LNNSSSSPQRSVDQR-----STSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESE 479
L + ++ QR A AS A E L + ++ S+
Sbjct: 2043 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSNAEDTLRSK 2099
Query: 480 NEGHLNPSEKLQKLNEVRKRLNELRELVHYY----EQTSDMMTDAVNE-NRKDEETEESE 534
+ L + + Q E +R E E V E+ + A+ E R + EE+
Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2159
Query: 535 YDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRA 594
E E ++ Q A+ + + A + + + + + +R
Sbjct: 2160 RLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR- 2217
Query: 595 LNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAE 654
GE E E+ EE +AE E L E A+
Sbjct: 2218 --------------GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2263
Query: 655 FEQKINRLMAAKQKLRQL--QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNN 712
+ AA +KLR+ Q+ Q + AA A+ + ++ E T
Sbjct: 2264 ARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT------ 2314
Query: 713 TRGNANKTQKDTGVNEKAREKFYEAKL--QQQQRELKQLQEERKKLIDIQEKIQALQTAC 770
R A Q+ T + + E ++ L ++ QR + E ++ ++E++ +++
Sbjct: 2315 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2374
Query: 771 PDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHE 830
+L A + + +T Q E K V E+++ + R +
Sbjct: 2375 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV--AEEAARLSVAAQEAARLRQ 2432
Query: 831 MLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATW 890
+ E+L Q+R E ++ E + Q + E A + + L Q R ++
Sbjct: 2433 LAEEDLAQQRALAEKMLKE--KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2490
Query: 891 GGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQ-DASSNDNFSVCPSNSVNHNSYNGKET 949
L EE ++G RT E E + Q + S+ ++ +E
Sbjct: 2491 AQQ----LAEE-------TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2539
Query: 950 KNRWKNNCPFSADENYRPLAKTRQ-----QNISMQRQENLRWVSEL-SYVEEKEQWQEQI 1003
R++ ++ +R T++ Q + +QRQ++ L + E E+ +E++
Sbjct: 2540 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2599
Query: 1004 NQLKKQLDFSVSICQTLMQDQ--QTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQC 1061
Q K L QT+ Q+Q Q L Q+ L+ S++ Q + QL
Sbjct: 2600 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--- 2656
Query: 1062 YTQLTWQQNNVQRLKQMLNELMRQQNQ 1088
Q+ V + +Q+ E RQQ Q
Sbjct: 2657 ------FQDEVAKAQQLREEQQRQQQQ 2677
Score = 52.0 bits (123), Expect = 6e-06
Identities = 187/1043 (17%), Positives = 385/1043 (36%), Gaps = 122/1043 (11%)
Query: 14 DQDLPNW---SNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSP 70
+++L W +NE + RL + Q+ A +EK K++ E+ +R ++
Sbjct: 1765 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR------GKAEE 1818
Query: 71 GVGRRRTKTPHTFPHSRYMSQMSVPEQ--AELEKLKQRINFSDLDQ-RSIGSDSQGR--- 124
R+R R +++ + ++ AE E ++ R +Q R + + R
Sbjct: 1819 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1878
Query: 125 -ATAANNKRQ-----LSENRKPFNFLPMQINTNKSKDASTSPPNRETIGS--AQCKELFA 176
A AA KRQ L++ R L + + STS +++ + + + +EL
Sbjct: 1879 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1938
Query: 177 SA-----LSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNE 231
A L+ + + Q++EED + A + +L I + T+ + E + E
Sbjct: 1939 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE-ATRLKTEAE--IALKE 1995
Query: 232 RSANVERLTHLID-------HLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLK 284
+ A ERL L + L+EQ + +++ LA+ + E L++Q L++
Sbjct: 1996 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLVE 2051
Query: 285 RMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELND 344
L+Q+ Q+ + +LAL+ E+A A + L I S + L
Sbjct: 2052 DTLRQRRQV------EEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRS 2098
Query: 345 LIQRFHNQLRDSQPPAVPDNRRQA------ESLSLTREVSQSRKPSASERLPDEKVELFS 398
Q R Q A + RR+ +SL+ E ++ RK +A E + K ++
Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEE 2157
Query: 399 KMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGES 458
R+ + +Q+ + L + L + +V Q+ L + E
Sbjct: 2158 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-------LQQTLQQEQ 2210
Query: 459 NSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMT 518
+ L A+ + E+E E Q +V + L++ Q
Sbjct: 2211 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAEEQAQARAQAQ 2269
Query: 519 DAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTV 578
A + RK+ E E + + + +R Q A E + Q +
Sbjct: 2270 AAAEKLRKEAEQEAARRAQAEQAA-----LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2324
Query: 579 NSNCEIN--------NRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE 630
+ + N ++ L + R + E+E+ + + +E + +A
Sbjct: 2325 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2384
Query: 631 EGVSGASLSSHRSS----LVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQ 686
E + A + + + L +E + + ++ RL A Q+ +L+ L ++D AQ
Sbjct: 2385 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA----EEDLAQ 2440
Query: 687 GVISASASNLDDFYPAEEDT--KQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQR 744
A + +E T K + + Q+ ++ +E+ + ++ Q
Sbjct: 2441 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2500
Query: 745 ELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETS 804
+ L+ ER++ +++ + + L+ ++ + A + A +++ E +
Sbjct: 2501 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2560
Query: 805 TSKSV-------FEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQ--RRQG 855
T + V + + S L + E +E+L+Q K L+ E Q +++
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2620
Query: 856 LAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRT 915
L + + S S+ L + EK Q DE +++
Sbjct: 2621 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE-----QLFQDE-------VAKAQQLR 2668
Query: 916 DEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQN 975
+E++ ++Q V + +E R E + L + R+Q
Sbjct: 2669 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--------KQEELQQLEQQRRQQ 2720
Query: 976 ISMQRQENLRWVSELSYVEEKEQ 998
+ +EN R +L +EE+ +
Sbjct: 2721 EELLAEENQRLREQLQLLEEQHR 2743
Score = 45.8 bits (107), Expect = 4e-04
Identities = 145/779 (18%), Positives = 283/779 (36%), Gaps = 99/779 (12%)
Query: 197 EPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKF 256
EP+ + + S L + + S+ +EK + + V R T + + + +K
Sbjct: 1192 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1251
Query: 257 LKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAV 316
+ + A P+ E + +LKK L + QQ AL+ + + +Q
Sbjct: 1252 AQAVPATLPELEATKA--SLKK---LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1306
Query: 317 MDDSV------VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA---VPDNRRQ 367
D V VA+ V +++ + + + R R+S P + D RR+
Sbjct: 1307 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1366
Query: 368 AESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNN 427
E + P A + E++ + + L E+ ++ + + E Q++N
Sbjct: 1367 QEQIQAM--------PLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINA 1415
Query: 428 SSSSPQRSVDQRSTSAPSASVGLAPVVNGESNS-----------------LTSS-VPYPT 469
+ V ++ P AS P V S S LTS + + +
Sbjct: 1416 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1475
Query: 470 ASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNE--NRKD 527
+L E E +E+ ++L EV L + R+L + Q E R
Sbjct: 1476 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1535
Query: 528 EET---EESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEI 584
EE EE+ D++ + + ++ S A+ + R + +
Sbjct: 1536 EEVVRREEAAVDAQQQKRS---------IQEELQQLRQSSEAEIQAKARQAEAAERS-RL 1585
Query: 585 NNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSS 644
+ L + + R EGE + A+ E+ E ++ +A+EE R
Sbjct: 1586 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQ 1639
Query: 645 LVDEHPEDAEFEQKINRLM-----AAKQKLRQLQDLVAM-VQDDDAAQGVISASASNLDD 698
+ DE + E ++ + AA++K R LQ L + +Q ++A + + A
Sbjct: 1640 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1699
Query: 699 FYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLID 758
A E ++++ A K EK + E LQ++ + QL+EE ++
Sbjct: 1700 VQVALETAQRSA-----EAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREEAERRAQ 1752
Query: 759 IQ-EKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSI 817
Q E +A + A +L+ + + E + KS+ + E
Sbjct: 1753 QQAEAERAREEAERELERWQLKANEALRLR----------LQAEEVAQQKSLAQAEAEKQ 1802
Query: 818 VDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAE---TASPVAVSLRSDGSEN 874
+ RR + + +RQR + L + Q +G A+ A + LR++ +
Sbjct: 1803 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1862
Query: 875 LCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLS------EGIVRTDEEEEEEQDASS 927
Q+ E+ +A A + + + L+ E ++ + EEE ++S
Sbjct: 1863 --EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1919
Score = 43.1 bits (100), Expect = 0.003
Identities = 127/677 (18%), Positives = 251/677 (37%), Gaps = 80/677 (11%)
Query: 218 KASSMREDLVEKNER-SANVERLTHLIDHLKEQEKSYMKFLKKILARDPQ-QEPMEEIEN 275
+A+ R+ +E+ ER A VE L + +++ ++ ++ + Q +E
Sbjct: 2136 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2195
Query: 276 LKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSIT 335
+K+ +L + + Q+Q L L+G A +AE+A + E A S V
Sbjct: 2196 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE----REAAQSRRQVEEA 2251
Query: 336 SELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQS----RKPSASERLPD 391
L + + Q R A R++AE + R ++ +K +A +
Sbjct: 2252 ERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2306
Query: 392 EKVELFSKMRVLQEKKQKMDKLLGELH------TLRDQHLNNSSSSPQRSVDQRSTSAPS 445
K +R + +Q++ L +L L D+ L + + QRS
Sbjct: 2307 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV--E 2364
Query: 446 ASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNP-SEKLQKLNEVRKRLN--- 501
+ V E + L + + +L+ +++ + L +EK++++ E RL+
Sbjct: 2365 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2424
Query: 502 ----ELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTW 557
LR+L + + + + + E + +E E + + Q
Sbjct: 2425 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL- 2483
Query: 558 NEVNSHSNAQCVSNNRDG--RTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHV 615
+ + AQ ++ G RT+ + + +A L + R E
Sbjct: 2484 -QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---------RVAEMSRAQ 2533
Query: 616 AQGEDDEEE-EEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQD 674
A+ E+D + ++AEE G HR+ L + +I R + R +
Sbjct: 2534 ARAEEDAQRFRKQAEEIGEK-----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2588
Query: 675 LVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKF 734
+ + ++ + Q ++ +++ + ++KD+ + RE+F
Sbjct: 2589 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ---RERF 2645
Query: 735 YEAKLQQQQRELKQL-QEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVT 793
E Q++ +L+QL Q+E K ++E+ Q Q ++ + A
Sbjct: 2646 IE----QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ------------ERQRLVASM 2689
Query: 794 STPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRR 853
QHE + E + E E+L EE ++ R+QL+ L E Q R
Sbjct: 2690 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----ELLAEENQRLREQLQLL--EEQHR 2743
Query: 854 QGLAE----TASPVAVS 866
LA TAS VA +
Sbjct: 2744 AALAHSEEVTASQVAAT 2760
Score = 41.2 bits (95), Expect = 0.010
Identities = 176/929 (18%), Positives = 336/929 (36%), Gaps = 106/929 (11%)
Query: 224 EDLVEKNERSANVERLTHLIDHLKEQEK-----SYMKFLKKILARDPQQEPMEEIENLKK 278
E+ + + +R+ ERL + L++Q + + K + A++ QQ EE+ ++
Sbjct: 1484 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1543
Query: 279 QH-DLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSE 337
D ++ QE+L+ L RQ++ +Q KA QA A + E + V + E
Sbjct: 1544 AAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEE--EIRVVRLQLE 1599
Query: 338 LNEELNDLIQRFHNQLRDSQPPAVPDNRR-QAESLSLTREVSQSRKPSASERLPDEKVEL 396
E + LR A R+ Q E+ L R+V S+R +VEL
Sbjct: 1600 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----SQRKRQAEVEL 1654
Query: 397 FSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNG 456
S+++ E ++ + L L LR Q Q V+ R+ A
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRSAEA 1713
Query: 457 ESNSLTSSVPYPTASL----------VSQNESENEGHLNPSEKLQKLNEVRKR------- 499
E S +S TA L V+Q E E + ++ E +R
Sbjct: 1714 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1773
Query: 500 -LNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRN--PQVAST 556
NE L E+ + + A E K +E E E + E R Q
Sbjct: 1774 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1833
Query: 557 WNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAA----NIRALNMPPSLDCRYNREGEQE 612
++ + Q ++ ++ + + E + + L + + +E E E
Sbjct: 1834 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1893
Query: 613 IHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQL 672
+ + E + +A E S ++ + L E E ++ RL A ++ ++
Sbjct: 1894 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1953
Query: 673 QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAR- 731
+ L ++DAA+ A + E T+ + K ++ + A
Sbjct: 1954 RQLA----EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 2009
Query: 732 EKFYEAKLQQQ--------QRELKQLQ-------EERKKLID--------IQEKIQALQT 768
E F +L++Q + L QL+ E +K L++ ++E+I AL+
Sbjct: 2010 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 2069
Query: 769 ACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRR 828
+ A+ G + + + S N +T SK E E + R+
Sbjct: 2070 S-----FEKAAAGKAELELELGRIRS----NAEDTLRSKEQAELEAA-----------RQ 2109
Query: 829 HEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMA 888
++ EE R+RR+ E + Q+ E A+ + + +++R + A
Sbjct: 2110 RQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2165
Query: 889 TWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKE 948
+ Q L +E + +E +++EQ+ ++ SV E
Sbjct: 2166 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ----TLQQEQSVLDQLRGEAE 2221
Query: 949 TKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKK 1008
R + + R A++R+Q ++ E L+ +E + + Q Q +L+K
Sbjct: 2222 AARRAAEEAEEARVQAEREAAQSRRQ---VEEAERLKQSAE-EQAQARAQAQAAAEKLRK 2277
Query: 1009 QLDFSVS----ICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQ-VHFIMHQLNQCYT 1063
+ + + Q ++ +Q ++ + Q + + QL +
Sbjct: 2278 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2337
Query: 1064 QLTWQQNNVQRLKQMLNELMRQQNQHPEK 1092
Q +QRLK E RQ++Q E+
Sbjct: 2338 QKNLLDEELQRLKAEATEAARQRSQVEEE 2366
Score = 38.9 bits (89), Expect = 0.052
Identities = 105/631 (16%), Positives = 241/631 (38%), Gaps = 60/631 (9%)
Query: 1419 RQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFE 1478
+QRAL AL+++ R +E E+ V + L ++ A + ++ +F
Sbjct: 1668 KQRALQALEEL--RLQAEEAERRLRQAEVERARQV--QVALETAQRSAEAELQSKRASFA 1723
Query: 1479 RETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARM-REYERMKTEAESN 1537
+T ++ ++ +V + E A ++A RE ER + +A
Sbjct: 1724 EKTAQLERSLQEEHVAVAQLREEAERRAQQQA-----EAERAREEAERELERWQLKANEA 1778
Query: 1538 SNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQI 1597
+R + EE E + ++ +E + + Q+L++Q
Sbjct: 1779 LRLRLQAEEVAQQKSLAQAEAEKQKEEA---EREARRRGKAEEQAVRQRELAEQELEKQ- 1834
Query: 1598 KAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSL 1657
+ E + Q L + + ++ L + ++ ++ + ++L + +++
Sbjct: 1835 ------------RQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAA 1881
Query: 1658 AKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEA-TGVIQS 1716
A R ++L E+++V + S + ++ K+++EA G +
Sbjct: 1882 AATQKR------QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1935
Query: 1717 CAKEAKRI--LEDHGSPAGEIDDED--KDKDETETVKQTQTSEVYDGPK-NVRSDISDQE 1771
A+EA R+ L + ++ +ED + + E E V + + + + + ++I+ +E
Sbjct: 1936 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1995
Query: 1772 EDEESEGC-----PVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANT 1826
++ E+E + + E QA + + E ++ + + ++ Q L +T
Sbjct: 1996 KEAENERLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSELERQKGLVEDT 2053
Query: 1827 -EATEENEHDEQVLQRDFKKTAESK---NVPLEREATSKND----QNNCPVKPCYLNIL- 1877
+ E + L+ F+K A K + L R ++ D + ++ L
Sbjct: 2054 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 2113
Query: 1878 -EDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAG-- 1934
E+E+ A + + L E+E L +V+E + +E E A
Sbjct: 2114 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2173
Query: 1935 --SPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKN 1992
+ + L + +A + + QK E ++ + + EA+ ++ EE ++
Sbjct: 2174 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2233
Query: 1993 HLSGEICEMQTEELAGNSETLKEPETVGAQS 2023
+ E Q+ +E LK+ AQ+
Sbjct: 2234 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2264
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 57.8 bits (138), Expect = 1e-07
Identities = 199/1107 (17%), Positives = 394/1107 (35%), Gaps = 107/1107 (9%)
Query: 36 AQQKKANRSSEKNKKKFGVESDKRVTNDISPES----SPGVGRRRTKTPHTFPHSRYMSQ 91
AQ+++A +E+ +++ ES ++ ++ S R + + R ++
Sbjct: 1465 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1524
Query: 92 MSVPE--QAELEKLKQRINFSDLDQRSIGSDSQG-RATAANNKRQLSENRKPFNFLPMQI 148
+ QAE+E+ +Q + QRS ++ Q RA+ A QL + + + Q+
Sbjct: 1525 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1584
Query: 149 NTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSR 208
+ A A+ +EL L + ++ E+ + ++ ++ +
Sbjct: 1585 REEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1643
Query: 209 LVQIRDYITKASSMREDLVEKNERSAN-VERLTHLIDHLKEQEKSYMKFLKKILARDPQQ 267
+ + E V + E + +E+ L + +Q + + L ++ A Q
Sbjct: 1644 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1703
Query: 268 EPM-----EEIENLKKQHDLLKRMLQQQE-QLRALQGRQAALLALQHKAEQAIAVMDDSV 321
E EE+ L+++ + Q+ E +L ++ LLA + +AE+ +
Sbjct: 1704 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1763
Query: 322 VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRR-------------QA 368
+E L L + Q + ++ A +A
Sbjct: 1764 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1823
Query: 369 ESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEK----KQKMDKLLGELHTLRDQH 424
L E++ K + +ERL + + R L+E+ K +++ L +L D
Sbjct: 1824 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1883
Query: 425 LNNSSSSPQRSVDQR-----STSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESE 479
L + ++ QR A AS A E L + ++ S+
Sbjct: 1884 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSNAEDTLRSK 1940
Query: 480 NEGHLNPSEKLQKLNEVRKRLNELRELVHYY----EQTSDMMTDAVNE-NRKDEETEESE 534
+ L + + Q E +R E E V E+ + A+ E R + EE+
Sbjct: 1941 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2000
Query: 535 YDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRA 594
E E ++ Q A+ + + A + + + + + +R
Sbjct: 2001 RLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR- 2058
Query: 595 LNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAE 654
GE E E+ EE +AE E L E A+
Sbjct: 2059 --------------GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2104
Query: 655 FEQKINRLMAAKQKLRQL--QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNN 712
+ AA +KLR+ Q+ Q + AA A+ + ++ E T
Sbjct: 2105 ARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT------ 2155
Query: 713 TRGNANKTQKDTGVNEKAREKFYEAKL--QQQQRELKQLQEERKKLIDIQEKIQALQTAC 770
R A Q+ T + + E ++ L ++ QR + E ++ ++E++ +++
Sbjct: 2156 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2215
Query: 771 PDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHE 830
+L A + + +T Q E K V E+++ + R +
Sbjct: 2216 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV--AEEAARLSVAAQEAARLRQ 2273
Query: 831 MLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATW 890
+ E+L Q+R E ++ E + Q + E A + + L Q R ++
Sbjct: 2274 LAEEDLAQQRALAEKMLKE--KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2331
Query: 891 GGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQ-DASSNDNFSVCPSNSVNHNSYNGKET 949
L EE ++G RT E E + Q + S+ ++ +E
Sbjct: 2332 AQQ----LAEE-------TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2380
Query: 950 KNRWKNNCPFSADENYRPLAKTRQ-----QNISMQRQENLRWVSEL-SYVEEKEQWQEQI 1003
R++ ++ +R T++ Q + +QRQ++ L + E E+ +E++
Sbjct: 2381 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2440
Query: 1004 NQLKKQLDFSVSICQTLMQDQ--QTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQC 1061
Q K L QT+ Q+Q Q L Q+ L+ S++ Q + QL
Sbjct: 2441 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--- 2497
Query: 1062 YTQLTWQQNNVQRLKQMLNELMRQQNQ 1088
Q+ V + +Q+ E RQQ Q
Sbjct: 2498 ------FQDEVAKAQQLREEQQRQQQQ 2518
Score = 52.0 bits (123), Expect = 6e-06
Identities = 187/1043 (17%), Positives = 385/1043 (36%), Gaps = 122/1043 (11%)
Query: 14 DQDLPNW---SNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSP 70
+++L W +NE + RL + Q+ A +EK K++ E+ +R ++
Sbjct: 1606 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR------GKAEE 1659
Query: 71 GVGRRRTKTPHTFPHSRYMSQMSVPEQ--AELEKLKQRINFSDLDQ-RSIGSDSQGR--- 124
R+R R +++ + ++ AE E ++ R +Q R + + R
Sbjct: 1660 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1719
Query: 125 -ATAANNKRQ-----LSENRKPFNFLPMQINTNKSKDASTSPPNRETIGS--AQCKELFA 176
A AA KRQ L++ R L + + STS +++ + + + +EL
Sbjct: 1720 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1779
Query: 177 SA-----LSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNE 231
A L+ + + Q++EED + A + +L I + T+ + E + E
Sbjct: 1780 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE-ATRLKTEAE--IALKE 1836
Query: 232 RSANVERLTHLID-------HLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLK 284
+ A ERL L + L+EQ + +++ LA+ + E L++Q L++
Sbjct: 1837 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLVE 1892
Query: 285 RMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELND 344
L+Q+ Q+ + +LAL+ E+A A + L I S + L
Sbjct: 1893 DTLRQRRQV------EEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRS 1939
Query: 345 LIQRFHNQLRDSQPPAVPDNRRQA------ESLSLTREVSQSRKPSASERLPDEKVELFS 398
Q R Q A + RR+ +SL+ E ++ RK +A E + K ++
Sbjct: 1940 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEE 1998
Query: 399 KMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGES 458
R+ + +Q+ + L + L + +V Q+ L + E
Sbjct: 1999 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-------LQQTLQQEQ 2051
Query: 459 NSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMT 518
+ L A+ + E+E E Q +V + L++ Q
Sbjct: 2052 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAEEQAQARAQAQ 2110
Query: 519 DAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTV 578
A + RK+ E E + + + +R Q A E + Q +
Sbjct: 2111 AAAEKLRKEAEQEAARRAQAEQAA-----LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2165
Query: 579 NSNCEIN--------NRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE 630
+ + N ++ L + R + E+E+ + + +E + +A
Sbjct: 2166 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2225
Query: 631 EGVSGASLSSHRSS----LVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQ 686
E + A + + + L +E + + ++ RL A Q+ +L+ L ++D AQ
Sbjct: 2226 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA----EEDLAQ 2281
Query: 687 GVISASASNLDDFYPAEEDT--KQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQR 744
A + +E T K + + Q+ ++ +E+ + ++ Q
Sbjct: 2282 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2341
Query: 745 ELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETS 804
+ L+ ER++ +++ + + L+ ++ + A + A +++ E +
Sbjct: 2342 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2401
Query: 805 TSKSV-------FEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQ--RRQG 855
T + V + + S L + E +E+L+Q K L+ E Q +++
Sbjct: 2402 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2461
Query: 856 LAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRT 915
L + + S S+ L + EK Q DE +++
Sbjct: 2462 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE-----QLFQDE-------VAKAQQLR 2509
Query: 916 DEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQN 975
+E++ ++Q V + +E R E + L + R+Q
Sbjct: 2510 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--------KQEELQQLEQQRRQQ 2561
Query: 976 ISMQRQENLRWVSELSYVEEKEQ 998
+ +EN R +L +EE+ +
Sbjct: 2562 EELLAEENQRLREQLQLLEEQHR 2584
Score = 45.8 bits (107), Expect = 4e-04
Identities = 145/779 (18%), Positives = 283/779 (36%), Gaps = 99/779 (12%)
Query: 197 EPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKF 256
EP+ + + S L + + S+ +EK + + V R T + + + +K
Sbjct: 1033 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1092
Query: 257 LKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAV 316
+ + A P+ E + +LKK L + QQ AL+ + + +Q
Sbjct: 1093 AQAVPATLPELEATKA--SLKK---LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1147
Query: 317 MDDSV------VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA---VPDNRRQ 367
D V VA+ V +++ + + + R R+S P + D RR+
Sbjct: 1148 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1207
Query: 368 AESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNN 427
E + P A + E++ + + L E+ ++ + + E Q++N
Sbjct: 1208 QEQIQAM--------PLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINA 1256
Query: 428 SSSSPQRSVDQRSTSAPSASVGLAPVVNGESNS-----------------LTSS-VPYPT 469
+ V ++ P AS P V S S LTS + + +
Sbjct: 1257 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1316
Query: 470 ASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNE--NRKD 527
+L E E +E+ ++L EV L + R+L + Q E R
Sbjct: 1317 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1376
Query: 528 EET---EESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEI 584
EE EE+ D++ + + ++ S A+ + R + +
Sbjct: 1377 EEVVRREEAAVDAQQQKRS---------IQEELQQLRQSSEAEIQAKARQAEAAERS-RL 1426
Query: 585 NNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSS 644
+ L + + R EGE + A+ E+ E ++ +A+EE R
Sbjct: 1427 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQ 1480
Query: 645 LVDEHPEDAEFEQKINRLM-----AAKQKLRQLQDLVAM-VQDDDAAQGVISASASNLDD 698
+ DE + E ++ + AA++K R LQ L + +Q ++A + + A
Sbjct: 1481 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1540
Query: 699 FYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLID 758
A E ++++ A K EK + E LQ++ + QL+EE ++
Sbjct: 1541 VQVALETAQRSA-----EAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREEAERRAQ 1593
Query: 759 IQ-EKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSI 817
Q E +A + A +L+ + + E + KS+ + E
Sbjct: 1594 QQAEAERAREEAERELERWQLKANEALRLR----------LQAEEVAQQKSLAQAEAEKQ 1643
Query: 818 VDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAE---TASPVAVSLRSDGSEN 874
+ RR + + +RQR + L + Q +G A+ A + LR++ +
Sbjct: 1644 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1703
Query: 875 LCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLS------EGIVRTDEEEEEEQDASS 927
Q+ E+ +A A + + + L+ E ++ + EEE ++S
Sbjct: 1704 --EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1760
Score = 43.1 bits (100), Expect = 0.003
Identities = 127/677 (18%), Positives = 251/677 (37%), Gaps = 80/677 (11%)
Query: 218 KASSMREDLVEKNER-SANVERLTHLIDHLKEQEKSYMKFLKKILARDPQ-QEPMEEIEN 275
+A+ R+ +E+ ER A VE L + +++ ++ ++ + Q +E
Sbjct: 1977 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2036
Query: 276 LKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSIT 335
+K+ +L + + Q+Q L L+G A +AE+A + E A S V
Sbjct: 2037 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE----REAAQSRRQVEEA 2092
Query: 336 SELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQS----RKPSASERLPD 391
L + + Q R A R++AE + R ++ +K +A +
Sbjct: 2093 ERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2147
Query: 392 EKVELFSKMRVLQEKKQKMDKLLGELH------TLRDQHLNNSSSSPQRSVDQRSTSAPS 445
K +R + +Q++ L +L L D+ L + + QRS
Sbjct: 2148 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV--E 2205
Query: 446 ASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNP-SEKLQKLNEVRKRLN--- 501
+ V E + L + + +L+ +++ + L +EK++++ E RL+
Sbjct: 2206 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2265
Query: 502 ----ELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTW 557
LR+L + + + + + E + +E E + + Q
Sbjct: 2266 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL- 2324
Query: 558 NEVNSHSNAQCVSNNRDG--RTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHV 615
+ + AQ ++ G RT+ + + +A L + R E
Sbjct: 2325 -QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---------RVAEMSRAQ 2374
Query: 616 AQGEDDEEE-EEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQD 674
A+ E+D + ++AEE G HR+ L + +I R + R +
Sbjct: 2375 ARAEEDAQRFRKQAEEIGEK-----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2429
Query: 675 LVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKF 734
+ + ++ + Q ++ +++ + ++KD+ + RE+F
Sbjct: 2430 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ---RERF 2486
Query: 735 YEAKLQQQQRELKQL-QEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVT 793
E Q++ +L+QL Q+E K ++E+ Q Q ++ + A
Sbjct: 2487 IE----QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ------------ERQRLVASM 2530
Query: 794 STPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRR 853
QHE + E + E E+L EE ++ R+QL+ L E Q R
Sbjct: 2531 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----ELLAEENQRLREQLQLL--EEQHR 2584
Query: 854 QGLAE----TASPVAVS 866
LA TAS VA +
Sbjct: 2585 AALAHSEEVTASQVAAT 2601
Score = 41.2 bits (95), Expect = 0.010
Identities = 176/929 (18%), Positives = 336/929 (36%), Gaps = 106/929 (11%)
Query: 224 EDLVEKNERSANVERLTHLIDHLKEQEK-----SYMKFLKKILARDPQQEPMEEIENLKK 278
E+ + + +R+ ERL + L++Q + + K + A++ QQ EE+ ++
Sbjct: 1325 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1384
Query: 279 QH-DLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSE 337
D ++ QE+L+ L RQ++ +Q KA QA A + E + V + E
Sbjct: 1385 AAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEE--EIRVVRLQLE 1440
Query: 338 LNEELNDLIQRFHNQLRDSQPPAVPDNRR-QAESLSLTREVSQSRKPSASERLPDEKVEL 396
E + LR A R+ Q E+ L R+V S+R +VEL
Sbjct: 1441 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----SQRKRQAEVEL 1495
Query: 397 FSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNG 456
S+++ E ++ + L L LR Q Q V+ R+ A
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRSAEA 1554
Query: 457 ESNSLTSSVPYPTASL----------VSQNESENEGHLNPSEKLQKLNEVRKR------- 499
E S +S TA L V+Q E E + ++ E +R
Sbjct: 1555 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1614
Query: 500 -LNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRN--PQVAST 556
NE L E+ + + A E K +E E E + E R Q
Sbjct: 1615 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1674
Query: 557 WNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAA----NIRALNMPPSLDCRYNREGEQE 612
++ + Q ++ ++ + + E + + L + + +E E E
Sbjct: 1675 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1734
Query: 613 IHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQL 672
+ + E + +A E S ++ + L E E ++ RL A ++ ++
Sbjct: 1735 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1794
Query: 673 QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAR- 731
+ L ++DAA+ A + E T+ + K ++ + A
Sbjct: 1795 RQLA----EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1850
Query: 732 EKFYEAKLQQQ--------QRELKQLQ-------EERKKLID--------IQEKIQALQT 768
E F +L++Q + L QL+ E +K L++ ++E+I AL+
Sbjct: 1851 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1910
Query: 769 ACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRR 828
+ A+ G + + + S N +T SK E E + R+
Sbjct: 1911 S-----FEKAAAGKAELELELGRIRS----NAEDTLRSKEQAELEAA-----------RQ 1950
Query: 829 HEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMA 888
++ EE R+RR+ E + Q+ E A+ + + +++R + A
Sbjct: 1951 RQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2006
Query: 889 TWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKE 948
+ Q L +E + +E +++EQ+ ++ SV E
Sbjct: 2007 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ----TLQQEQSVLDQLRGEAE 2062
Query: 949 TKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKK 1008
R + + R A++R+Q ++ E L+ +E + + Q Q +L+K
Sbjct: 2063 AARRAAEEAEEARVQAEREAAQSRRQ---VEEAERLKQSAE-EQAQARAQAQAAAEKLRK 2118
Query: 1009 QLDFSVS----ICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQ-VHFIMHQLNQCYT 1063
+ + + Q ++ +Q ++ + Q + + QL +
Sbjct: 2119 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2178
Query: 1064 QLTWQQNNVQRLKQMLNELMRQQNQHPEK 1092
Q +QRLK E RQ++Q E+
Sbjct: 2179 QKNLLDEELQRLKAEATEAARQRSQVEEE 2207
Score = 38.9 bits (89), Expect = 0.052
Identities = 105/631 (16%), Positives = 241/631 (38%), Gaps = 60/631 (9%)
Query: 1419 RQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFE 1478
+QRAL AL+++ R +E E+ V + L ++ A + ++ +F
Sbjct: 1509 KQRALQALEEL--RLQAEEAERRLRQAEVERARQV--QVALETAQRSAEAELQSKRASFA 1564
Query: 1479 RETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARM-REYERMKTEAESN 1537
+T ++ ++ +V + E A ++A RE ER + +A
Sbjct: 1565 EKTAQLERSLQEEHVAVAQLREEAERRAQQQA-----EAERAREEAERELERWQLKANEA 1619
Query: 1538 SNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQI 1597
+R + EE E + ++ +E + + Q+L++Q
Sbjct: 1620 LRLRLQAEEVAQQKSLAQAEAEKQKEEA---EREARRRGKAEEQAVRQRELAEQELEKQ- 1675
Query: 1598 KAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSL 1657
+ E + Q L + + ++ L + ++ ++ + ++L + +++
Sbjct: 1676 ------------RQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAA 1722
Query: 1658 AKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEA-TGVIQS 1716
A R ++L E+++V + S + ++ K+++EA G +
Sbjct: 1723 AATQKR------QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1776
Query: 1717 CAKEAKRI--LEDHGSPAGEIDDED--KDKDETETVKQTQTSEVYDGPK-NVRSDISDQE 1771
A+EA R+ L + ++ +ED + + E E V + + + + + ++I+ +E
Sbjct: 1777 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1836
Query: 1772 EDEESEGC-----PVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANT 1826
++ E+E + + E QA + + E ++ + + ++ Q L +T
Sbjct: 1837 KEAENERLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSELERQKGLVEDT 1894
Query: 1827 -EATEENEHDEQVLQRDFKKTAESK---NVPLEREATSKND----QNNCPVKPCYLNIL- 1877
+ E + L+ F+K A K + L R ++ D + ++ L
Sbjct: 1895 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1954
Query: 1878 -EDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAG-- 1934
E+E+ A + + L E+E L +V+E + +E E A
Sbjct: 1955 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2014
Query: 1935 --SPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKN 1992
+ + L + +A + + QK E ++ + + EA+ ++ EE ++
Sbjct: 2015 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2074
Query: 1993 HLSGEICEMQTEELAGNSETLKEPETVGAQS 2023
+ E Q+ +E LK+ AQ+
Sbjct: 2075 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2105
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 57.8 bits (138), Expect = 1e-07
Identities = 199/1107 (17%), Positives = 394/1107 (35%), Gaps = 107/1107 (9%)
Query: 36 AQQKKANRSSEKNKKKFGVESDKRVTNDISPES----SPGVGRRRTKTPHTFPHSRYMSQ 91
AQ+++A +E+ +++ ES ++ ++ S R + + R ++
Sbjct: 1473 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1532
Query: 92 MSVPE--QAELEKLKQRINFSDLDQRSIGSDSQG-RATAANNKRQLSENRKPFNFLPMQI 148
+ QAE+E+ +Q + QRS ++ Q RA+ A QL + + + Q+
Sbjct: 1533 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1592
Query: 149 NTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSR 208
+ A A+ +EL L + ++ E+ + ++ ++ +
Sbjct: 1593 REEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1651
Query: 209 LVQIRDYITKASSMREDLVEKNERSAN-VERLTHLIDHLKEQEKSYMKFLKKILARDPQQ 267
+ + E V + E + +E+ L + +Q + + L ++ A Q
Sbjct: 1652 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1711
Query: 268 EPM-----EEIENLKKQHDLLKRMLQQQE-QLRALQGRQAALLALQHKAEQAIAVMDDSV 321
E EE+ L+++ + Q+ E +L ++ LLA + +AE+ +
Sbjct: 1712 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1771
Query: 322 VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRR-------------QA 368
+E L L + Q + ++ A +A
Sbjct: 1772 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1831
Query: 369 ESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEK----KQKMDKLLGELHTLRDQH 424
L E++ K + +ERL + + R L+E+ K +++ L +L D
Sbjct: 1832 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1891
Query: 425 LNNSSSSPQRSVDQR-----STSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESE 479
L + ++ QR A AS A E L + ++ S+
Sbjct: 1892 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSNAEDTLRSK 1948
Query: 480 NEGHLNPSEKLQKLNEVRKRLNELRELVHYY----EQTSDMMTDAVNE-NRKDEETEESE 534
+ L + + Q E +R E E V E+ + A+ E R + EE+
Sbjct: 1949 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2008
Query: 535 YDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRA 594
E E ++ Q A+ + + A + + + + + +R
Sbjct: 2009 RLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR- 2066
Query: 595 LNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAE 654
GE E E+ EE +AE E L E A+
Sbjct: 2067 --------------GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2112
Query: 655 FEQKINRLMAAKQKLRQL--QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNN 712
+ AA +KLR+ Q+ Q + AA A+ + ++ E T
Sbjct: 2113 ARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT------ 2163
Query: 713 TRGNANKTQKDTGVNEKAREKFYEAKL--QQQQRELKQLQEERKKLIDIQEKIQALQTAC 770
R A Q+ T + + E ++ L ++ QR + E ++ ++E++ +++
Sbjct: 2164 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2223
Query: 771 PDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHE 830
+L A + + +T Q E K V E+++ + R +
Sbjct: 2224 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV--AEEAARLSVAAQEAARLRQ 2281
Query: 831 MLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATW 890
+ E+L Q+R E ++ E + Q + E A + + L Q R ++
Sbjct: 2282 LAEEDLAQQRALAEKMLKE--KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2339
Query: 891 GGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQ-DASSNDNFSVCPSNSVNHNSYNGKET 949
L EE ++G RT E E + Q + S+ ++ +E
Sbjct: 2340 AQQ----LAEE-------TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2388
Query: 950 KNRWKNNCPFSADENYRPLAKTRQ-----QNISMQRQENLRWVSEL-SYVEEKEQWQEQI 1003
R++ ++ +R T++ Q + +QRQ++ L + E E+ +E++
Sbjct: 2389 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2448
Query: 1004 NQLKKQLDFSVSICQTLMQDQ--QTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQC 1061
Q K L QT+ Q+Q Q L Q+ L+ S++ Q + QL
Sbjct: 2449 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--- 2505
Query: 1062 YTQLTWQQNNVQRLKQMLNELMRQQNQ 1088
Q+ V + +Q+ E RQQ Q
Sbjct: 2506 ------FQDEVAKAQQLREEQQRQQQQ 2526
Score = 52.0 bits (123), Expect = 6e-06
Identities = 187/1043 (17%), Positives = 385/1043 (36%), Gaps = 122/1043 (11%)
Query: 14 DQDLPNW---SNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSP 70
+++L W +NE + RL + Q+ A +EK K++ E+ +R ++
Sbjct: 1614 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR------GKAEE 1667
Query: 71 GVGRRRTKTPHTFPHSRYMSQMSVPEQ--AELEKLKQRINFSDLDQ-RSIGSDSQGR--- 124
R+R R +++ + ++ AE E ++ R +Q R + + R
Sbjct: 1668 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1727
Query: 125 -ATAANNKRQ-----LSENRKPFNFLPMQINTNKSKDASTSPPNRETIGS--AQCKELFA 176
A AA KRQ L++ R L + + STS +++ + + + +EL
Sbjct: 1728 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1787
Query: 177 SA-----LSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNE 231
A L+ + + Q++EED + A + +L I + T+ + E + E
Sbjct: 1788 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE-ATRLKTEAE--IALKE 1844
Query: 232 RSANVERLTHLID-------HLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLK 284
+ A ERL L + L+EQ + +++ LA+ + E L++Q L++
Sbjct: 1845 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLVE 1900
Query: 285 RMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELND 344
L+Q+ Q+ + +LAL+ E+A A + L I S + L
Sbjct: 1901 DTLRQRRQV------EEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRS 1947
Query: 345 LIQRFHNQLRDSQPPAVPDNRRQA------ESLSLTREVSQSRKPSASERLPDEKVELFS 398
Q R Q A + RR+ +SL+ E ++ RK +A E + K ++
Sbjct: 1948 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEE 2006
Query: 399 KMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGES 458
R+ + +Q+ + L + L + +V Q+ L + E
Sbjct: 2007 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-------LQQTLQQEQ 2059
Query: 459 NSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMT 518
+ L A+ + E+E E Q +V + L++ Q
Sbjct: 2060 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAEEQAQARAQAQ 2118
Query: 519 DAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTV 578
A + RK+ E E + + + +R Q A E + Q +
Sbjct: 2119 AAAEKLRKEAEQEAARRAQAEQAA-----LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2173
Query: 579 NSNCEIN--------NRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE 630
+ + N ++ L + R + E+E+ + + +E + +A
Sbjct: 2174 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2233
Query: 631 EGVSGASLSSHRSS----LVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQ 686
E + A + + + L +E + + ++ RL A Q+ +L+ L ++D AQ
Sbjct: 2234 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA----EEDLAQ 2289
Query: 687 GVISASASNLDDFYPAEEDT--KQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQR 744
A + +E T K + + Q+ ++ +E+ + ++ Q
Sbjct: 2290 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2349
Query: 745 ELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETS 804
+ L+ ER++ +++ + + L+ ++ + A + A +++ E +
Sbjct: 2350 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2409
Query: 805 TSKSV-------FEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQ--RRQG 855
T + V + + S L + E +E+L+Q K L+ E Q +++
Sbjct: 2410 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2469
Query: 856 LAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRT 915
L + + S S+ L + EK Q DE +++
Sbjct: 2470 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE-----QLFQDE-------VAKAQQLR 2517
Query: 916 DEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQN 975
+E++ ++Q V + +E R E + L + R+Q
Sbjct: 2518 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--------KQEELQQLEQQRRQQ 2569
Query: 976 ISMQRQENLRWVSELSYVEEKEQ 998
+ +EN R +L +EE+ +
Sbjct: 2570 EELLAEENQRLREQLQLLEEQHR 2592
Score = 45.8 bits (107), Expect = 4e-04
Identities = 145/779 (18%), Positives = 283/779 (36%), Gaps = 99/779 (12%)
Query: 197 EPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKF 256
EP+ + + S L + + S+ +EK + + V R T + + + +K
Sbjct: 1041 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1100
Query: 257 LKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAV 316
+ + A P+ E + +LKK L + QQ AL+ + + +Q
Sbjct: 1101 AQAVPATLPELEATKA--SLKK---LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1155
Query: 317 MDDSV------VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA---VPDNRRQ 367
D V VA+ V +++ + + + R R+S P + D RR+
Sbjct: 1156 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1215
Query: 368 AESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNN 427
E + P A + E++ + + L E+ ++ + + E Q++N
Sbjct: 1216 QEQIQAM--------PLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINA 1264
Query: 428 SSSSPQRSVDQRSTSAPSASVGLAPVVNGESNS-----------------LTSS-VPYPT 469
+ V ++ P AS P V S S LTS + + +
Sbjct: 1265 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1324
Query: 470 ASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNE--NRKD 527
+L E E +E+ ++L EV L + R+L + Q E R
Sbjct: 1325 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1384
Query: 528 EET---EESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEI 584
EE EE+ D++ + + ++ S A+ + R + +
Sbjct: 1385 EEVVRREEAAVDAQQQKRS---------IQEELQQLRQSSEAEIQAKARQAEAAERS-RL 1434
Query: 585 NNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSS 644
+ L + + R EGE + A+ E+ E ++ +A+EE R
Sbjct: 1435 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQ 1488
Query: 645 LVDEHPEDAEFEQKINRLM-----AAKQKLRQLQDLVAM-VQDDDAAQGVISASASNLDD 698
+ DE + E ++ + AA++K R LQ L + +Q ++A + + A
Sbjct: 1489 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1548
Query: 699 FYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLID 758
A E ++++ A K EK + E LQ++ + QL+EE ++
Sbjct: 1549 VQVALETAQRSA-----EAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREEAERRAQ 1601
Query: 759 IQ-EKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSI 817
Q E +A + A +L+ + + E + KS+ + E
Sbjct: 1602 QQAEAERAREEAERELERWQLKANEALRLR----------LQAEEVAQQKSLAQAEAEKQ 1651
Query: 818 VDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAE---TASPVAVSLRSDGSEN 874
+ RR + + +RQR + L + Q +G A+ A + LR++ +
Sbjct: 1652 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1711
Query: 875 LCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLS------EGIVRTDEEEEEEQDASS 927
Q+ E+ +A A + + + L+ E ++ + EEE ++S
Sbjct: 1712 --EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1768
Score = 43.1 bits (100), Expect = 0.003
Identities = 127/677 (18%), Positives = 251/677 (37%), Gaps = 80/677 (11%)
Query: 218 KASSMREDLVEKNER-SANVERLTHLIDHLKEQEKSYMKFLKKILARDPQ-QEPMEEIEN 275
+A+ R+ +E+ ER A VE L + +++ ++ ++ + Q +E
Sbjct: 1985 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2044
Query: 276 LKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSIT 335
+K+ +L + + Q+Q L L+G A +AE+A + E A S V
Sbjct: 2045 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE----REAAQSRRQVEEA 2100
Query: 336 SELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQS----RKPSASERLPD 391
L + + Q R A R++AE + R ++ +K +A +
Sbjct: 2101 ERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2155
Query: 392 EKVELFSKMRVLQEKKQKMDKLLGELH------TLRDQHLNNSSSSPQRSVDQRSTSAPS 445
K +R + +Q++ L +L L D+ L + + QRS
Sbjct: 2156 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV--E 2213
Query: 446 ASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNP-SEKLQKLNEVRKRLN--- 501
+ V E + L + + +L+ +++ + L +EK++++ E RL+
Sbjct: 2214 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2273
Query: 502 ----ELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTW 557
LR+L + + + + + E + +E E + + Q
Sbjct: 2274 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL- 2332
Query: 558 NEVNSHSNAQCVSNNRDG--RTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHV 615
+ + AQ ++ G RT+ + + +A L + R E
Sbjct: 2333 -QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---------RVAEMSRAQ 2382
Query: 616 AQGEDDEEE-EEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQD 674
A+ E+D + ++AEE G HR+ L + +I R + R +
Sbjct: 2383 ARAEEDAQRFRKQAEEIGEK-----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2437
Query: 675 LVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKF 734
+ + ++ + Q ++ +++ + ++KD+ + RE+F
Sbjct: 2438 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ---RERF 2494
Query: 735 YEAKLQQQQRELKQL-QEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVT 793
E Q++ +L+QL Q+E K ++E+ Q Q ++ + A
Sbjct: 2495 IE----QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ------------ERQRLVASM 2538
Query: 794 STPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRR 853
QHE + E + E E+L EE ++ R+QL+ L E Q R
Sbjct: 2539 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----ELLAEENQRLREQLQLL--EEQHR 2592
Query: 854 QGLAE----TASPVAVS 866
LA TAS VA +
Sbjct: 2593 AALAHSEEVTASQVAAT 2609
Score = 41.2 bits (95), Expect = 0.010
Identities = 176/929 (18%), Positives = 336/929 (36%), Gaps = 106/929 (11%)
Query: 224 EDLVEKNERSANVERLTHLIDHLKEQEK-----SYMKFLKKILARDPQQEPMEEIENLKK 278
E+ + + +R+ ERL + L++Q + + K + A++ QQ EE+ ++
Sbjct: 1333 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1392
Query: 279 QH-DLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSE 337
D ++ QE+L+ L RQ++ +Q KA QA A + E + V + E
Sbjct: 1393 AAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEE--EIRVVRLQLE 1448
Query: 338 LNEELNDLIQRFHNQLRDSQPPAVPDNRR-QAESLSLTREVSQSRKPSASERLPDEKVEL 396
E + LR A R+ Q E+ L R+V S+R +VEL
Sbjct: 1449 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----SQRKRQAEVEL 1503
Query: 397 FSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNG 456
S+++ E ++ + L L LR Q Q V+ R+ A
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRSAEA 1562
Query: 457 ESNSLTSSVPYPTASL----------VSQNESENEGHLNPSEKLQKLNEVRKR------- 499
E S +S TA L V+Q E E + ++ E +R
Sbjct: 1563 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1622
Query: 500 -LNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRN--PQVAST 556
NE L E+ + + A E K +E E E + E R Q
Sbjct: 1623 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1682
Query: 557 WNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAA----NIRALNMPPSLDCRYNREGEQE 612
++ + Q ++ ++ + + E + + L + + +E E E
Sbjct: 1683 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1742
Query: 613 IHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQL 672
+ + E + +A E S ++ + L E E ++ RL A ++ ++
Sbjct: 1743 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1802
Query: 673 QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAR- 731
+ L ++DAA+ A + E T+ + K ++ + A
Sbjct: 1803 RQLA----EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1858
Query: 732 EKFYEAKLQQQ--------QRELKQLQ-------EERKKLID--------IQEKIQALQT 768
E F +L++Q + L QL+ E +K L++ ++E+I AL+
Sbjct: 1859 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1918
Query: 769 ACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRR 828
+ A+ G + + + S N +T SK E E + R+
Sbjct: 1919 S-----FEKAAAGKAELELELGRIRS----NAEDTLRSKEQAELEAA-----------RQ 1958
Query: 829 HEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMA 888
++ EE R+RR+ E + Q+ E A+ + + +++R + A
Sbjct: 1959 RQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2014
Query: 889 TWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKE 948
+ Q L +E + +E +++EQ+ ++ SV E
Sbjct: 2015 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ----TLQQEQSVLDQLRGEAE 2070
Query: 949 TKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKK 1008
R + + R A++R+Q ++ E L+ +E + + Q Q +L+K
Sbjct: 2071 AARRAAEEAEEARVQAEREAAQSRRQ---VEEAERLKQSAE-EQAQARAQAQAAAEKLRK 2126
Query: 1009 QLDFSVS----ICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQ-VHFIMHQLNQCYT 1063
+ + + Q ++ +Q ++ + Q + + QL +
Sbjct: 2127 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2186
Query: 1064 QLTWQQNNVQRLKQMLNELMRQQNQHPEK 1092
Q +QRLK E RQ++Q E+
Sbjct: 2187 QKNLLDEELQRLKAEATEAARQRSQVEEE 2215
Score = 38.9 bits (89), Expect = 0.052
Identities = 105/631 (16%), Positives = 241/631 (38%), Gaps = 60/631 (9%)
Query: 1419 RQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFE 1478
+QRAL AL+++ R +E E+ V + L ++ A + ++ +F
Sbjct: 1517 KQRALQALEEL--RLQAEEAERRLRQAEVERARQV--QVALETAQRSAEAELQSKRASFA 1572
Query: 1479 RETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARM-REYERMKTEAESN 1537
+T ++ ++ +V + E A ++A RE ER + +A
Sbjct: 1573 EKTAQLERSLQEEHVAVAQLREEAERRAQQQA-----EAERAREEAERELERWQLKANEA 1627
Query: 1538 SNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQI 1597
+R + EE E + ++ +E + + Q+L++Q
Sbjct: 1628 LRLRLQAEEVAQQKSLAQAEAEKQKEEA---EREARRRGKAEEQAVRQRELAEQELEKQ- 1683
Query: 1598 KAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSL 1657
+ E + Q L + + ++ L + ++ ++ + ++L + +++
Sbjct: 1684 ------------RQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAA 1730
Query: 1658 AKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEA-TGVIQS 1716
A R ++L E+++V + S + ++ K+++EA G +
Sbjct: 1731 AATQKR------QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1784
Query: 1717 CAKEAKRI--LEDHGSPAGEIDDED--KDKDETETVKQTQTSEVYDGPK-NVRSDISDQE 1771
A+EA R+ L + ++ +ED + + E E V + + + + + ++I+ +E
Sbjct: 1785 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1844
Query: 1772 EDEESEGC-----PVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANT 1826
++ E+E + + E QA + + E ++ + + ++ Q L +T
Sbjct: 1845 KEAENERLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSELERQKGLVEDT 1902
Query: 1827 -EATEENEHDEQVLQRDFKKTAESK---NVPLEREATSKND----QNNCPVKPCYLNIL- 1877
+ E + L+ F+K A K + L R ++ D + ++ L
Sbjct: 1903 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1962
Query: 1878 -EDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAG-- 1934
E+E+ A + + L E+E L +V+E + +E E A
Sbjct: 1963 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2022
Query: 1935 --SPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKN 1992
+ + L + +A + + QK E ++ + + EA+ ++ EE ++
Sbjct: 2023 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2082
Query: 1993 HLSGEICEMQTEELAGNSETLKEPETVGAQS 2023
+ E Q+ +E LK+ AQ+
Sbjct: 2083 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2113
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 57.8 bits (138), Expect = 1e-07
Identities = 199/1107 (17%), Positives = 394/1107 (35%), Gaps = 107/1107 (9%)
Query: 36 AQQKKANRSSEKNKKKFGVESDKRVTNDISPES----SPGVGRRRTKTPHTFPHSRYMSQ 91
AQ+++A +E+ +++ ES ++ ++ S R + + R ++
Sbjct: 1514 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1573
Query: 92 MSVPE--QAELEKLKQRINFSDLDQRSIGSDSQG-RATAANNKRQLSENRKPFNFLPMQI 148
+ QAE+E+ +Q + QRS ++ Q RA+ A QL + + + Q+
Sbjct: 1574 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1633
Query: 149 NTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSR 208
+ A A+ +EL L + ++ E+ + ++ ++ +
Sbjct: 1634 REEAERRAQQQAEAERAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1692
Query: 209 LVQIRDYITKASSMREDLVEKNERSAN-VERLTHLIDHLKEQEKSYMKFLKKILARDPQQ 267
+ + E V + E + +E+ L + +Q + + L ++ A Q
Sbjct: 1693 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1752
Query: 268 EPM-----EEIENLKKQHDLLKRMLQQQE-QLRALQGRQAALLALQHKAEQAIAVMDDSV 321
E EE+ L+++ + Q+ E +L ++ LLA + +AE+ +
Sbjct: 1753 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1812
Query: 322 VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRR-------------QA 368
+E L L + Q + ++ A +A
Sbjct: 1813 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1872
Query: 369 ESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEK----KQKMDKLLGELHTLRDQH 424
L E++ K + +ERL + + R L+E+ K +++ L +L D
Sbjct: 1873 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1932
Query: 425 LNNSSSSPQRSVDQR-----STSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESE 479
L + ++ QR A AS A E L + ++ S+
Sbjct: 1933 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE---LELELGRIRSNAEDTLRSK 1989
Query: 480 NEGHLNPSEKLQKLNEVRKRLNELRELVHYY----EQTSDMMTDAVNE-NRKDEETEESE 534
+ L + + Q E +R E E V E+ + A+ E R + EE+
Sbjct: 1990 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2049
Query: 535 YDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRA 594
E E ++ Q A+ + + A + + + + + +R
Sbjct: 2050 RLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR- 2107
Query: 595 LNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAE 654
GE E E+ EE +AE E L E A+
Sbjct: 2108 --------------GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2153
Query: 655 FEQKINRLMAAKQKLRQL--QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNN 712
+ AA +KLR+ Q+ Q + AA A+ + ++ E T
Sbjct: 2154 ARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT------ 2204
Query: 713 TRGNANKTQKDTGVNEKAREKFYEAKL--QQQQRELKQLQEERKKLIDIQEKIQALQTAC 770
R A Q+ T + + E ++ L ++ QR + E ++ ++E++ +++
Sbjct: 2205 LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2264
Query: 771 PDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHE 830
+L A + + +T Q E K V E+++ + R +
Sbjct: 2265 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV--AEEAARLSVAAQEAARLRQ 2322
Query: 831 MLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATW 890
+ E+L Q+R E ++ E + Q + E A + + L Q R ++
Sbjct: 2323 LAEEDLAQQRALAEKMLKE--KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2380
Query: 891 GGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQ-DASSNDNFSVCPSNSVNHNSYNGKET 949
L EE ++G RT E E + Q + S+ ++ +E
Sbjct: 2381 AQQ----LAEE-------TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEED 2429
Query: 950 KNRWKNNCPFSADENYRPLAKTRQ-----QNISMQRQENLRWVSEL-SYVEEKEQWQEQI 1003
R++ ++ +R T++ Q + +QRQ++ L + E E+ +E++
Sbjct: 2430 AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2489
Query: 1004 NQLKKQLDFSVSICQTLMQDQ--QTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQC 1061
Q K L QT+ Q+Q Q L Q+ L+ S++ Q + QL
Sbjct: 2490 QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL--- 2546
Query: 1062 YTQLTWQQNNVQRLKQMLNELMRQQNQ 1088
Q+ V + +Q+ E RQQ Q
Sbjct: 2547 ------FQDEVAKAQQLREEQQRQQQQ 2567
Score = 52.0 bits (123), Expect = 6e-06
Identities = 187/1043 (17%), Positives = 385/1043 (36%), Gaps = 122/1043 (11%)
Query: 14 DQDLPNW---SNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSP 70
+++L W +NE + RL + Q+ A +EK K++ E+ +R ++
Sbjct: 1655 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR------GKAEE 1708
Query: 71 GVGRRRTKTPHTFPHSRYMSQMSVPEQ--AELEKLKQRINFSDLDQ-RSIGSDSQGR--- 124
R+R R +++ + ++ AE E ++ R +Q R + + R
Sbjct: 1709 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR 1768
Query: 125 -ATAANNKRQ-----LSENRKPFNFLPMQINTNKSKDASTSPPNRETIGS--AQCKELFA 176
A AA KRQ L++ R L + + STS +++ + + + +EL
Sbjct: 1769 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828
Query: 177 SA-----LSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNE 231
A L+ + + Q++EED + A + +L I + T+ + E + E
Sbjct: 1829 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE-ATRLKTEAE--IALKE 1885
Query: 232 RSANVERLTHLID-------HLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLK 284
+ A ERL L + L+EQ + +++ LA+ + E L++Q L++
Sbjct: 1886 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE----LERQKGLVE 1941
Query: 285 RMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELND 344
L+Q+ Q+ + +LAL+ E+A A + L I S + L
Sbjct: 1942 DTLRQRRQV------EEEILALKASFEKAAA-------GKAELELELGRIRSNAEDTLRS 1988
Query: 345 LIQRFHNQLRDSQPPAVPDNRRQA------ESLSLTREVSQSRKPSASERLPDEKVELFS 398
Q R Q A + RR+ +SL+ E ++ RK +A E + K ++
Sbjct: 1989 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK-AALEEVERLKAKVEE 2047
Query: 399 KMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGES 458
R+ + +Q+ + L + L + +V Q+ L + E
Sbjct: 2048 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE-------LQQTLQQEQ 2100
Query: 459 NSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMT 518
+ L A+ + E+E E Q +V + L++ Q
Sbjct: 2101 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAEEQAQARAQAQ 2159
Query: 519 DAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTV 578
A + RK+ E E + + + +R Q A E + Q +
Sbjct: 2160 AAAEKLRKEAEQEAARRAQAEQAA-----LRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2214
Query: 579 NSNCEIN--------NRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE 630
+ + N ++ L + R + E+E+ + + +E + +A
Sbjct: 2215 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2274
Query: 631 EGVSGASLSSHRSS----LVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQ 686
E + A + + + L +E + + ++ RL A Q+ +L+ L ++D AQ
Sbjct: 2275 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA----EEDLAQ 2330
Query: 687 GVISASASNLDDFYPAEEDT--KQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQR 744
A + +E T K + + Q+ ++ +E+ + ++ Q
Sbjct: 2331 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2390
Query: 745 ELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETS 804
+ L+ ER++ +++ + + L+ ++ + A + A +++ E +
Sbjct: 2391 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2450
Query: 805 TSKSV-------FEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQ--RRQG 855
T + V + + S L + E +E+L+Q K L+ E Q +++
Sbjct: 2451 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2510
Query: 856 LAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRT 915
L + + S S+ L + EK Q DE +++
Sbjct: 2511 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE-----QLFQDE-------VAKAQQLR 2558
Query: 916 DEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQN 975
+E++ ++Q V + +E R E + L + R+Q
Sbjct: 2559 EEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR--------KQEELQQLEQQRRQQ 2610
Query: 976 ISMQRQENLRWVSELSYVEEKEQ 998
+ +EN R +L +EE+ +
Sbjct: 2611 EELLAEENQRLREQLQLLEEQHR 2633
Score = 45.8 bits (107), Expect = 4e-04
Identities = 145/779 (18%), Positives = 283/779 (36%), Gaps = 99/779 (12%)
Query: 197 EPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKF 256
EP+ + + S L + + S+ +EK + + V R T + + + +K
Sbjct: 1082 EPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKE 1141
Query: 257 LKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAV 316
+ + A P+ E + +LKK L + QQ AL+ + + +Q
Sbjct: 1142 AQAVPATLPELEATKA--SLKK---LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE 1196
Query: 317 MDDSV------VAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA---VPDNRRQ 367
D V VA+ V +++ + + + R R+S P + D RR+
Sbjct: 1197 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1256
Query: 368 AESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNN 427
E + P A + E++ + + L E+ ++ + + E Q++N
Sbjct: 1257 QEQIQAM--------PLADSQAVREQLR---QEQALLEEIERHGEKVEECQRFAKQYINA 1305
Query: 428 SSSSPQRSVDQRSTSAPSASVGLAPVVNGESNS-----------------LTSS-VPYPT 469
+ V ++ P AS P V S S LTS + + +
Sbjct: 1306 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1365
Query: 470 ASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNE--NRKD 527
+L E E +E+ ++L EV L + R+L + Q E R
Sbjct: 1366 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1425
Query: 528 EET---EESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEI 584
EE EE+ D++ + + ++ S A+ + R + +
Sbjct: 1426 EEVVRREEAAVDAQQQKRS---------IQEELQQLRQSSEAEIQAKARQAEAAERS-RL 1475
Query: 585 NNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSS 644
+ L + + R EGE + A+ E+ E ++ +A+EE R
Sbjct: 1476 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQ 1529
Query: 645 LVDEHPEDAEFEQKINRLM-----AAKQKLRQLQDLVAM-VQDDDAAQGVISASASNLDD 698
+ DE + E ++ + AA++K R LQ L + +Q ++A + + A
Sbjct: 1530 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1589
Query: 699 FYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLID 758
A E ++++ A K EK + E LQ++ + QL+EE ++
Sbjct: 1590 VQVALETAQRSA-----EAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREEAERRAQ 1642
Query: 759 IQ-EKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSI 817
Q E +A + A +L+ + + E + KS+ + E
Sbjct: 1643 QQAEAERAREEAERELERWQLKANEALRLR----------LQAEEVAQQKSLAQAEAEKQ 1692
Query: 818 VDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAE---TASPVAVSLRSDGSEN 874
+ RR + + +RQR + L + Q +G A+ A + LR++ +
Sbjct: 1693 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1752
Query: 875 LCTPQQSRTEKTMATWGGSTQCALDEEGDEDGYLS------EGIVRTDEEEEEEQDASS 927
Q+ E+ +A A + + + L+ E ++ + EEE ++S
Sbjct: 1753 --EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1809
Score = 43.1 bits (100), Expect = 0.003
Identities = 127/677 (18%), Positives = 251/677 (37%), Gaps = 80/677 (11%)
Query: 218 KASSMREDLVEKNER-SANVERLTHLIDHLKEQEKSYMKFLKKILARDPQ-QEPMEEIEN 275
+A+ R+ +E+ ER A VE L + +++ ++ ++ + Q +E
Sbjct: 2026 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2085
Query: 276 LKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSIT 335
+K+ +L + + Q+Q L L+G A +AE+A + E A S V
Sbjct: 2086 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE----REAAQSRRQVEEA 2141
Query: 336 SELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQS----RKPSASERLPD 391
L + + Q R A R++AE + R ++ +K +A +
Sbjct: 2142 ERLKQSAEE-----QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2196
Query: 392 EKVELFSKMRVLQEKKQKMDKLLGELH------TLRDQHLNNSSSSPQRSVDQRSTSAPS 445
K +R + +Q++ L +L L D+ L + + QRS
Sbjct: 2197 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV--E 2254
Query: 446 ASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNP-SEKLQKLNEVRKRLN--- 501
+ V E + L + + +L+ +++ + L +EK++++ E RL+
Sbjct: 2255 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2314
Query: 502 ----ELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTW 557
LR+L + + + + + E + +E E + + Q
Sbjct: 2315 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL- 2373
Query: 558 NEVNSHSNAQCVSNNRDG--RTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHV 615
+ + AQ ++ G RT+ + + +A L + R E
Sbjct: 2374 -QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL---------RVAEMSRAQ 2423
Query: 616 AQGEDDEEE-EEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQD 674
A+ E+D + ++AEE G HR+ L + +I R + R +
Sbjct: 2424 ARAEEDAQRFRKQAEEIGEK-----LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2478
Query: 675 LVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKF 734
+ + ++ + Q ++ +++ + ++KD+ + RE+F
Sbjct: 2479 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ---RERF 2535
Query: 735 YEAKLQQQQRELKQL-QEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVT 793
E Q++ +L+QL Q+E K ++E+ Q Q ++ + A
Sbjct: 2536 IE----QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ------------ERQRLVASM 2579
Query: 794 STPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRR 853
QHE + E + E E+L EE ++ R+QL+ L E Q R
Sbjct: 2580 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----ELLAEENQRLREQLQLL--EEQHR 2633
Query: 854 QGLAE----TASPVAVS 866
LA TAS VA +
Sbjct: 2634 AALAHSEEVTASQVAAT 2650
Score = 41.2 bits (95), Expect = 0.010
Identities = 176/929 (18%), Positives = 336/929 (36%), Gaps = 106/929 (11%)
Query: 224 EDLVEKNERSANVERLTHLIDHLKEQEK-----SYMKFLKKILARDPQQEPMEEIENLKK 278
E+ + + +R+ ERL + L++Q + + K + A++ QQ EE+ ++
Sbjct: 1374 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1433
Query: 279 QH-DLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSE 337
D ++ QE+L+ L RQ++ +Q KA QA A + E + V + E
Sbjct: 1434 AAVDAQQQKRSIQEELQQL--RQSSEAEIQAKARQAEAAERSRLRIEE--EIRVVRLQLE 1489
Query: 338 LNEELNDLIQRFHNQLRDSQPPAVPDNRR-QAESLSLTREVSQSRKPSASERLPDEKVEL 396
E + LR A R+ Q E+ L R+V S+R +VEL
Sbjct: 1490 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----SQRKRQAEVEL 1544
Query: 397 FSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNG 456
S+++ E ++ + L L LR Q Q V+ R+ A
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRSAEA 1603
Query: 457 ESNSLTSSVPYPTASL----------VSQNESENEGHLNPSEKLQKLNEVRKR------- 499
E S +S TA L V+Q E E + ++ E +R
Sbjct: 1604 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1663
Query: 500 -LNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRN--PQVAST 556
NE L E+ + + A E K +E E E + E R Q
Sbjct: 1664 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1723
Query: 557 WNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAA----NIRALNMPPSLDCRYNREGEQE 612
++ + Q ++ ++ + + E + + L + + +E E E
Sbjct: 1724 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1783
Query: 613 IHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQL 672
+ + E + +A E S ++ + L E E ++ RL A ++ ++
Sbjct: 1784 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1843
Query: 673 QDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAR- 731
+ L ++DAA+ A + E T+ + K ++ + A
Sbjct: 1844 RQLA----EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAED 1899
Query: 732 EKFYEAKLQQQ--------QRELKQLQ-------EERKKLID--------IQEKIQALQT 768
E F +L++Q + L QL+ E +K L++ ++E+I AL+
Sbjct: 1900 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1959
Query: 769 ACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRR 828
+ A+ G + + + S N +T SK E E + R+
Sbjct: 1960 S-----FEKAAAGKAELELELGRIRS----NAEDTLRSKEQAELEAA-----------RQ 1999
Query: 829 HEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMA 888
++ EE R+RR+ E + Q+ E A+ + + +++R + A
Sbjct: 2000 RQLAAEEERRRREAEERV----QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2055
Query: 889 TWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKE 948
+ Q L +E + +E +++EQ+ ++ SV E
Sbjct: 2056 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ----TLQQEQSVLDQLRGEAE 2111
Query: 949 TKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKK 1008
R + + R A++R+Q ++ E L+ +E + + Q Q +L+K
Sbjct: 2112 AARRAAEEAEEARVQAEREAAQSRRQ---VEEAERLKQSAE-EQAQARAQAQAAAEKLRK 2167
Query: 1009 QLDFSVS----ICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQ-VHFIMHQLNQCYT 1063
+ + + Q ++ +Q ++ + Q + + QL +
Sbjct: 2168 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH 2227
Query: 1064 QLTWQQNNVQRLKQMLNELMRQQNQHPEK 1092
Q +QRLK E RQ++Q E+
Sbjct: 2228 QKNLLDEELQRLKAEATEAARQRSQVEEE 2256
Score = 38.9 bits (89), Expect = 0.052
Identities = 105/631 (16%), Positives = 241/631 (38%), Gaps = 60/631 (9%)
Query: 1419 RQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFE 1478
+QRAL AL+++ R +E E+ V + L ++ A + ++ +F
Sbjct: 1558 KQRALQALEEL--RLQAEEAERRLRQAEVERARQV--QVALETAQRSAEAELQSKRASFA 1613
Query: 1479 RETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARM-REYERMKTEAESN 1537
+T ++ ++ +V + E A ++A RE ER + +A
Sbjct: 1614 EKTAQLERSLQEEHVAVAQLREEAERRAQQQA-----EAERAREEAERELERWQLKANEA 1668
Query: 1538 SNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQI 1597
+R + EE E + ++ +E + + Q+L++Q
Sbjct: 1669 LRLRLQAEEVAQQKSLAQAEAEKQKEEA---EREARRRGKAEEQAVRQRELAEQELEKQ- 1724
Query: 1598 KAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSL 1657
+ E + Q L + + ++ L + ++ ++ + ++L + +++
Sbjct: 1725 ------------RQLAEGTAQQRLAAEQELI-RLRAETEQGEQQRQLLEEELARLQREAA 1771
Query: 1658 AKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEA-TGVIQS 1716
A R ++L E+++V + S + ++ K+++EA G +
Sbjct: 1772 AATQKR------QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1825
Query: 1717 CAKEAKRI--LEDHGSPAGEIDDED--KDKDETETVKQTQTSEVYDGPK-NVRSDISDQE 1771
A+EA R+ L + ++ +ED + + E E V + + + + + ++I+ +E
Sbjct: 1826 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1885
Query: 1772 EDEESEGC-----PVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANT 1826
++ E+E + + E QA + + E ++ + + ++ Q L +T
Sbjct: 1886 KEAENERLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSELERQKGLVEDT 1943
Query: 1827 -EATEENEHDEQVLQRDFKKTAESK---NVPLEREATSKND----QNNCPVKPCYLNIL- 1877
+ E + L+ F+K A K + L R ++ D + ++ L
Sbjct: 1944 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 2003
Query: 1878 -EDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQETPESSLAG-- 1934
E+E+ A + + L E+E L +V+E + +E E A
Sbjct: 2004 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2063
Query: 1935 --SPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKN 1992
+ + L + +A + + QK E ++ + + EA+ ++ EE ++
Sbjct: 2064 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2123
Query: 1993 HLSGEICEMQTEELAGNSETLKEPETVGAQS 2023
+ E Q+ +E LK+ AQ+
Sbjct: 2124 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2154
>gi|115511012 coiled-coil domain containing 136 [Homo sapiens]
Length = 1154
Score = 57.8 bits (138), Expect = 1e-07
Identities = 154/742 (20%), Positives = 296/742 (39%), Gaps = 141/742 (19%)
Query: 192 EDGRGEPAMESSQIVSRLVQIRDYITKASSMREDL-VEKNERSANVERLTHLIDHLKEQE 250
ED R A ++ ++ Q++ + S+RE++ + ++E+ + ++ + + HL + E
Sbjct: 94 EDERLASAQQAEVFTKQIQQLQGELR---SLREEISLLEHEKESELKEIEQEL-HLAQAE 149
Query: 251 KSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKA 310
++ A D E +I +L++ ++ L+ E++R + A L + +
Sbjct: 150 IQSLRQA----AEDSATEHESDIASLQEDLCRMQNELEDMERIRGDYEMEIASLRAEMEM 205
Query: 311 EQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFH-----------------NQL 353
+ + E +GSL G+S S L EEL +L +R+H QL
Sbjct: 206 KSS----------EPSGSL-GLSDYSGLQEELQELRERYHFLNEEYRALQESNSSLTGQL 254
Query: 354 RD---SQPPAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELF-SKMRVLQEK--- 406
D + + Q+++LS+T SQ+ + E PD +++L ++R +E+
Sbjct: 255 ADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLE--PDPEMQLLRQQLRDAEEQMHG 312
Query: 407 -KQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPS------ASVGLAPVVNGESN 459
K K +L EL L QH S QR + + A + S + +S
Sbjct: 313 MKNKCQELCCELEEL--QHHRQVSEEEQRRLQRELKCAQNEVLRFQTSHSVTQNEELKSR 370
Query: 460 SLTSSVPYPTA-------------------------SLVSQNESENE----------GHL 484
T Y T+ S + +N+SE E H
Sbjct: 371 LCTLQKKYDTSQDEQNELLKMQLQLQTELRQLKVMKSTLVENQSEKELLCRLQKLHLQHQ 430
Query: 485 NPSEKLQKLNEVRKRLNE-----------LRELVHYYEQTSDMMTDA---------VNEN 524
N + + +KL E +++L E LR+ V ++++++ T+ + +
Sbjct: 431 NVTCEKEKLLERQQQLQEELQCHEAELQHLRDTVASFKESNEKDTETHAQLQEMKQLYQA 490
Query: 525 RKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEI 584
KDE + + E + + ++ ++ +C N+ ++ E+
Sbjct: 491 SKDELERQKHMYDQLEQDLLLCQLELKELKAS--HPIPEDKGKCA--NKCDTLLSRLTEL 546
Query: 585 NNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSS 644
+ A+ + + C E ++ + QG+ EE SG L S
Sbjct: 547 QEKYKASQKEMGQLQMEQCEL-LEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQE-- 603
Query: 645 LVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEE 704
L+ + + E + + ++KL Q QD V + + + + + S+ + +
Sbjct: 604 LLTKLEDLCELQLLYQGMQEEQKKLIQNQDCV-LKEQLEIHEELRRFKESHFQEVLENPD 662
Query: 705 DTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQ---QRELKQLQEERKKL-IDIQ 760
D+K + +++ N NK K +A + Y+A +Q Q+E +L EERK+L D+Q
Sbjct: 663 DSKL-AKSSKCNRNKQSKLLMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQ 721
Query: 761 ---EKIQALQTACPDLQLSAASVG-----------NCPTKKYMPAVTSTPTVNQHETST- 805
E++Q LQ P +++S S G NC K Y V + + TST
Sbjct: 722 LCLEEMQLLQVQSPSIKMSLESYGKSYGSMVPSNENC-RKTYDTTVDDNESYYKSYTSTQ 780
Query: 806 --SKSVFEPEDSSIVDNELWSE 825
SKS + DSS +E + +
Sbjct: 781 TSSKSFLKSYDSSTSASEAYGK 802
Score = 51.6 bits (122), Expect = 8e-06
Identities = 115/527 (21%), Positives = 196/527 (37%), Gaps = 76/527 (14%)
Query: 601 LDCRYNREGEQEIHVAQGEDDEEEEEEAEEEG-VSGASLSSHRSSLVDEHPEDAEFEQKI 659
L Y E E+E + E+ EEEEE+ ++ G V S++ HR + E E E+
Sbjct: 10 LPALYEEEEEEE---EEEEEVEEEEEQVQKGGSVGSLSVNKHRGLSLTE----TELEELR 62
Query: 660 NRLMAAKQKLRQLQDLVAMVQDDD-AAQGVISASASNLDDFYPAEEDTKQNSNNTRGNAN 718
+++ +L + ++L +DD QG++ L AE TKQ +G
Sbjct: 63 AQVLQLVAELEETRELAGQHEDDSLELQGLL--EDERLASAQQAEVFTKQ-IQQLQGELR 119
Query: 719 KTQKDTGVNEKARE---KFYEAKLQQQQRELKQLQ--------EERKKLIDIQEKIQALQ 767
+++ + E +E K E +L Q E++ L+ E + +QE + +Q
Sbjct: 120 SLREEISLLEHEKESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQ 179
Query: 768 TACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMR 827
D++ Y + S + ++S D S + EL
Sbjct: 180 NELEDMERIRGD--------YEMEIASLRAEMEMKSSEPSGSLGLSDYSGLQEELQELRE 231
Query: 828 RHEMLREELRQRRK-------QLEALMAEHQRR--------QGLAETASPVAVS----LR 868
R+ L EE R ++ QL L +E +R Q L+ T++ S L
Sbjct: 232 RYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLE 291
Query: 869 SDGSENLCTPQQSRTEKTMATWGGSTQ--CALDEEGDEDGYLSEGIVRTDEEEEEEQDAS 926
D L Q E+ M Q C EE +SE + E +
Sbjct: 292 PDPEMQLLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSE---EEQRRLQRELKCA 348
Query: 927 SNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRW 986
N+ S+SV N +E K+R C + + + +Q Q LR
Sbjct: 349 QNEVLRFQTSHSVTQN----EELKSRL---CTLQKKYDTSQDEQNELLKMQLQLQTELRQ 401
Query: 987 VSEL-SYVEEKEQWQEQINQLKK-QLDFSVSIC---------QTLMQDQQTLSCLLQTLL 1035
+ + S + E + +E + +L+K L C Q L ++ Q LQ L
Sbjct: 402 LKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHLR 461
Query: 1036 TGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLNEL 1082
S SN + H + ++ Q Y ++ ++R K M ++L
Sbjct: 462 DTVASFKESNEKDTETHAQLQEMKQLYQA---SKDELERQKHMYDQL 505
Score = 48.1 bits (113), Expect = 9e-05
Identities = 65/313 (20%), Positives = 132/313 (42%), Gaps = 50/313 (15%)
Query: 258 KKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRAL-QGRQAALLALQHKAEQAIAV 316
K ++ +EP E E++++ +++ ++L + + ++A+ Q Q LQ + E+ +A
Sbjct: 829 KSFVSSCTDEEPAEP-EDMERFEEMVVKVLIKLQAVQAMYQISQEEHSQLQEQMEKLLAK 887
Query: 317 MDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQA--ESLSLT 374
D L EEL+ + F + + P P N + E +
Sbjct: 888 QKD------------------LKEELDACEREFKECMECLEKPMAPQNDKNEIKELQTKL 929
Query: 375 REVSQSRKPSASE--RLPDEKVELFSKMRVLQEK-KQKMDKLLGELHTLRDQHLNNSSSS 431
RE+ + S E RL + +L +++ QE+ +Q +K + R ++ N + +
Sbjct: 930 RELQLQYQASMDEQGRLLVVQEQLEGQLQCCQEELRQLREKRPSVVKEARGKNANKNMNK 989
Query: 432 PQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQ 491
V + + P + + + E+ V Y AS + + +G EK +
Sbjct: 990 NANGVKMKKVTKPCSDTSESDL---ETRKSLEVVLYYKAS-----QRKLDGLAKEEEKKE 1041
Query: 492 KLNEVRKRLNELRELVHYYEQTSDMM------------TDAVNENRKDEETEESEYDSEH 539
++ E +K++ E + EQ D + T+ EN +D+E EE E DSE
Sbjct: 1042 EMEEEKKQVKEEAK-----EQCGDELVAEPADPEEAKSTEDQEENEEDKEEEEKEEDSEE 1096
Query: 540 ENSEPVTNIRNPQ 552
E + +++ +P+
Sbjct: 1097 EEDDADSSLESPE 1109
Score = 45.1 bits (105), Expect = 7e-04
Identities = 164/924 (17%), Positives = 344/924 (37%), Gaps = 134/924 (14%)
Query: 97 QAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDA 156
Q EL++L++R +F + + R++ + + R +L Q + S ++
Sbjct: 223 QEELQELRERYHFLNEEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAES 282
Query: 157 STSPPN-----------RETIGSAQ---------CKELFASALSNDLLQNCQVSEEDGRG 196
TS + R+ + A+ C+EL +L + QVSEE+ R
Sbjct: 283 QTSEMDFLEPDPEMQLLRQQLRDAEEQMHGMKNKCQELCCEL--EELQHHRQVSEEEQRR 340
Query: 197 -EPAMESSQIVSRLVQIRDYITKASSMREDL--VEKNERSANVERLTHLIDHLKEQ-EKS 252
+ ++ +Q Q +T+ ++ L ++K ++ E+ L L+ Q E
Sbjct: 341 LQRELKCAQNEVLRFQTSHSVTQNEELKSRLCTLQKKYDTSQDEQNELLKMQLQLQTELR 400
Query: 253 YMKFLKKILARDP-QQEPMEEIENLKKQHDLL----KRMLQQQEQLRA-LQGRQAALLAL 306
+K +K L + ++E + ++ L QH + +++L++Q+QL+ LQ +A L L
Sbjct: 401 QLKVMKSTLVENQSEKELLCRLQKLHLQHQNVTCEKEKLLERQQQLQEELQCHEAELQHL 460
Query: 307 QHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRR 366
+ +A +S +T E + +L ++ Q + + + ++
Sbjct: 461 R----DTVASFKESNEKDT-----------ETHAQLQEMKQLYQASKDELERQKHMYDQL 505
Query: 367 QAESLSLTREVSQSRKPSASERLPDEKVE-------LFSKMRVLQEKKQKMDKLLGELHT 419
+ + L E+ + + AS +P++K + L S++ LQEK + K +G+L
Sbjct: 506 EQDLLLCQLELKELK---ASHPIPEDKGKCANKCDTLLSRLTELQEKYKASQKEMGQLQM 562
Query: 420 -----LRDQH-LNNSSSSPQRSVDQRSTSAPSASVGLAP---------------VVNGES 458
L DQ + Q + + + P + + L + G
Sbjct: 563 EQCELLEDQRRMQEEQGQLQEELHRLTLPLPKSGLLLKSQELLTKLEDLCELQLLYQGMQ 622
Query: 459 NSLTSSVPYPTASLVSQNESENE------GHL-----NPSE-KLQKLNEVRKRLNELREL 506
+ L Q E E H NP + KL K ++ + N+ +L
Sbjct: 623 EEQKKLIQNQDCVLKEQLEIHEELRRFKESHFQEVLENPDDSKLAKSSKCNR--NKQSKL 680
Query: 507 VHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEP----------VTNIRNPQVAST 556
+ Q +M DA ++ + E+ E + + + +++P + +
Sbjct: 681 LMEQMQALQVMYDAGQAKQELLQQEQGRLLEERKRLQADLQLCLEEMQLLQVQSPSIKMS 740
Query: 557 WNEVNSHSNAQCVSNNRDGRTVNSNCEINNR-----SAANIRALNMPPSLDCRYNR-EGE 610
+ SN +T ++ + N ++ + + S D + E
Sbjct: 741 LESYGKSYGSMVPSNENCRKTYDTTVDDNESYYKSYTSTQTSSKSFLKSYDSSTSASEAY 800
Query: 611 QEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLR 670
+ + ++ S S SS DE P + E ++ ++ + L
Sbjct: 801 GKSYCTTSNSSITYKKSYGSTSSSDTCQKSFVSSCTDEEPAEPEDMERFEEMVV--KVLI 858
Query: 671 QLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKD-----TG 725
+LQ + AM Q +Q S ++ ++D K+ + + +
Sbjct: 859 KLQAVQAMYQ---ISQEEHSQLQEQMEKLLAKQKDLKEELDACEREFKECMECLEKPMAP 915
Query: 726 VNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPT 785
N+K K + KL++ Q + + +E+ +L+ +QE+++ Q C +L
Sbjct: 916 QNDKNEIKELQTKLRELQLQYQASMDEQGRLLVVQEQLEG-QLQCCQEELRQLREKRPSV 974
Query: 786 KKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEA 845
K + +N++ S +++L + +L + QR+ L+
Sbjct: 975 VKEARGKNANKNMNKNANGVKMKKVTKPCSDTSESDLETRKSLEVVLYYKASQRK--LDG 1032
Query: 846 LMAEHQRRQGLAETASPVAVSLRSD-GSENLCTPQQSRTEKTMATWGGSTQCALDEEGDE 904
L E ++++ + E V + G E + P K+ EE +E
Sbjct: 1033 LAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPEEAKSTED---------QEENEE 1083
Query: 905 DGYLSEGIVRTDEEEEEEQDASSN 928
D E + ++ EEEE DA S+
Sbjct: 1084 D---KEEEEKEEDSEEEEDDADSS 1104
Score = 37.0 bits (84), Expect = 0.20
Identities = 48/208 (23%), Positives = 76/208 (36%), Gaps = 38/208 (18%)
Query: 1712 GVIQSCAKEAKRILEDHGSPAGEIDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQE 1771
G +Q C +E +++ E S E ++ +K+ + + +V SD S+ +
Sbjct: 955 GQLQCCQEELRQLREKRPSVVKEARGKNANKNMNKNANGVKMKKV----TKPCSDTSESD 1010
Query: 1772 -EDEESEGCPVSINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQA------ 1824
E +S + S+ + L ++E E+E+ + EE L A
Sbjct: 1011 LETRKSLEVVLYYKASQRKLDGLAKEEEKKEEMEEEKKQVKEEAKEQCGDELVAEPADPE 1070
Query: 1825 ---NTEATEENEHDEQVLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYLNILEDEQ 1881
+TE EENE D K E K E E + P E+
Sbjct: 1071 EAKSTEDQEENEED---------KEEEEKEEDSEEEEDDADSSLESP---------EENN 1112
Query: 1882 PLNSAAHKESPPTVDSTQQPNPLPLRLP 1909
PL + K+S PT PNP LP
Sbjct: 1113 PLRLSESKKSSPT------PNPPIFSLP 1134
Score = 33.1 bits (74), Expect = 2.8
Identities = 58/296 (19%), Positives = 115/296 (38%), Gaps = 28/296 (9%)
Query: 1725 LEDHGSPAGEIDDEDKDKD---ETETVKQTQTSEVYDGP--------KNVRSDISDQEED 1773
LE+ AG+ +D+ + E E + Q +EV+ +++R +IS E +
Sbjct: 72 LEETRELAGQHEDDSLELQGLLEDERLASAQQAEVFTKQIQQLQGELRSLREEISLLEHE 131
Query: 1774 EESEGCPV--SINLSKAETQALTNYGSGEDENEDEEMEEFEEGPVDVQTSLQANTEATEE 1831
+ESE + ++L++AE Q+L + ++ +E +Q L+
Sbjct: 132 KESELKEIEQELHLAQAEIQSLRQAAEDSATEHESDIASLQEDLCRMQNELE-------- 183
Query: 1832 NEHDEQVLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYLNILEDEQPLNSAAHKES 1891
D + ++ D++ S +E +++ + Y + E+ Q L H +
Sbjct: 184 ---DMERIRGDYEMEIASLRAEMEMKSSEPSGSLGL---SDYSGLQEELQELRERYHFLN 237
Query: 1892 PPTVDSTQQPNPLPLRLPEME-PLVPRVKEVKSAQETPESSLAGSPDTESPVLVNDYEAE 1950
+ + L +L ++E R E +T + A S +E L D E +
Sbjct: 238 EEYRALQESNSSLTGQLADLESERTQRATERWLQSQTLSMTSAESQTSEMDFLEPDPEMQ 297
Query: 1951 SGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKNHLSGEICEMQTEEL 2006
+ EE +++ +L E + V EE++ L E+ Q E L
Sbjct: 298 LLRQQLRDAEEQMHGMKNKCQELCCELEELQHHRQVSEEEQRRLQRELKCAQNEVL 353
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 57.4 bits (137), Expect = 1e-07
Identities = 146/803 (18%), Positives = 316/803 (39%), Gaps = 84/803 (10%)
Query: 22 NENVDDRLNNMDWGAQQKKANRSS-EKNKKKF------------GVESDKRVTNDISPES 68
N ++ + ++++ +Q+K R+ E+ K+K +E+DK+ + +
Sbjct: 1028 NAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKK 1087
Query: 69 SPGVGRRRTKTPHTFPHSRYMSQMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAA 128
+ + + K HS + QA +E+L++ I + I + R+ A
Sbjct: 1088 EFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKI---EKQRSDLA 1144
Query: 129 NNKRQLSEN-RKPFNFLPMQINTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNC 187
++SE + QI NK ++A R+ + E A+ L
Sbjct: 1145 RELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK----- 1199
Query: 188 QVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLK 247
+ + E + + L +++ + K S E +E ++ ++N+E L+ +++
Sbjct: 1200 -------QADSVAELGEQIDNLQRVKQKLEKEKS--ELKMEIDDMASNIEALSKSKSNIE 1250
Query: 248 EQEKSYMKFLKKILARDPQQEPMEEIENLKK-----QHDLLKRMLQQQEQLRALQGRQAA 302
++ +I A+D QQ + N++K Q+ L ++++E L + +
Sbjct: 1251 RTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESL--ISQLTKS 1308
Query: 303 LLALQHKAEQAIAVMDDSVVAETA------GSLSGVSITSELNEELNDLIQRFHNQL-RD 355
AL + E+ M++ A+ A S + E EE + L +
Sbjct: 1309 KQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKA 1368
Query: 356 SQPPAVPDNRRQAESLSLTREVSQSRKPSASE-RLPDEKVELF-SKMRVLQEKKQKMDKL 413
+ A + + +++ T E+ +++K A + +E E SK L++ KQ++
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGE 1428
Query: 414 LGELHTLRDQHLNNSS----SSPQRSVDQ---RSTSAPSASVGLAPVVNGESNSLTS--- 463
+ +L +RD ++++ QR+ D+ S ES SL++
Sbjct: 1429 VEDL--MRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELF 1486
Query: 464 SVPYPTASLVSQNESENEGHLNPSEKL----QKLNEVRKRLNELRELVHYYEQTSDMMTD 519
+ +V Q E+ + N E++ +++ E K L E + EQ +
Sbjct: 1487 KMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQV 1546
Query: 520 AVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEV-----NSHSNAQCVSNNRD 574
A+ E E EES+ V + + +V E+ NS A+ + + D
Sbjct: 1547 ALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLD 1606
Query: 575 G--RTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGE--DDEEEEEEA-- 628
R+ N + + ++ + + R E ++ + QG+ D + ++A
Sbjct: 1607 AEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALR 1666
Query: 629 -EEEGVSGASLSSHRSSLVDEHPEDAE--FEQKINRLMAAKQKLRQLQDLVAMVQDDDAA 685
E+ ++ R+ L+ E E+ + EQ ++Q+L D V ++ + +
Sbjct: 1667 SNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTS 1726
Query: 686 QGVISASASNLDDFYPAE---EDTKQNSNNTRGNANKTQKDTGV--NEKAREKFYEAKLQ 740
+I+ D + E++ Q S N A K D + E +E+ A L+
Sbjct: 1727 --LINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1784
Query: 741 QQQRELKQLQEERKKLIDIQEKI 763
+ ++ L+Q ++ + +D E++
Sbjct: 1785 RMKKNLEQTVKDLQHRLDEAEQL 1807
Score = 51.6 bits (122), Expect = 8e-06
Identities = 161/802 (20%), Positives = 311/802 (38%), Gaps = 117/802 (14%)
Query: 284 KRMLQQQEQLRALQGRQAALLALQH-----------------KAEQAIAVMDDSVVAETA 326
K+M+++++ + +Q + + ++H +AE+ +A M +
Sbjct: 806 KKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEMATMKEDFERTKE 865
Query: 327 GSLSGVSITSELNEELNDLIQRFHN-QLR-DSQPPAVPDNRRQAESLSLTREVSQSRKPS 384
+ EL E++ L+Q ++ QL+ S+ + D + E L ++ + +++
Sbjct: 866 ELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKE 925
Query: 385 ASERLPDEKV---ELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRST 441
+ERL +E+ EL +K R L++K + + + +L L + + + V S
Sbjct: 926 LTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLE-LTLTKVEKEKHATENKVKNLSE 984
Query: 442 SAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESEN----------------EGHLN 485
+ ++ + E SL + L + + N EG L
Sbjct: 985 EMTALEENISKLTK-EKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLE 1043
Query: 486 PSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDA--VNENRKDEETEESEYDSEHENSE 543
+KL+ E KR E +L E D+ D + E K +E E S+ ++ ++ E
Sbjct: 1044 QEKKLRADLERAKRKLE-GDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDD-E 1101
Query: 544 PVTNIR--------NPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRAL 595
V +++ ++ E+ + + + EI+ R +
Sbjct: 1102 QVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISER----LEEA 1157
Query: 596 NMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEF 655
+ S N++ E E + + EE + + A+L ++ V AE
Sbjct: 1158 SGATSAQIEMNKKREAEFQKMR----RDLEEATLQHEATAATLRKKQADSV------AEL 1207
Query: 656 EQKINRLMAAKQKLRQLQDLVAMVQDDDAAQ-GVISASASNLDDFYPAEEDTKQNSNNTR 714
++I+ L KQKL + + + M DD A+ +S S SN++ ED Q S
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVED--QFSEIKA 1265
Query: 715 GNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLI-DIQEKIQALQTACPDL 773
+ +TQ +N + +A+LQ Q EL EE++ LI + + QAL +L
Sbjct: 1266 KDEQQTQLIHDLNMQ------KARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEEL 1319
Query: 774 QLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDS---------SIVDNELWS 824
+ K A+ ++H+ + +E E S ++E+
Sbjct: 1320 KRQMEE-----ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQ 1374
Query: 825 EMRRHE----MLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQ 880
++E EEL + +K+L + E + ETA+ SL E Q
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQEAEEN---TETANSKCASL-----EKTKQRLQ 1426
Query: 881 SRTEKTMATWGGS-TQCA-LD-EEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSN 937
E M S T CA LD ++ + D L+E + D E + E +A+ ++ S+
Sbjct: 1427 GEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLD-ESQAELEAAQKESRSLSTEL 1485
Query: 938 SVNHNSY----NGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYV 993
N+Y + ET R N + +A+T + ++Q E + + E
Sbjct: 1486 FKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGK---NLQEAEKTKKLVE---- 1538
Query: 994 EEKEQWQEQINQLKKQLDFSVS 1015
+EK Q + +++ L+ S
Sbjct: 1539 QEKSDLQVALEEVEGSLEHEES 1560
Score = 36.2 bits (82), Expect = 0.34
Identities = 92/476 (19%), Positives = 186/476 (39%), Gaps = 81/476 (17%)
Query: 1457 SELTPSESLATTDDETFEKNFERETHKIS---EQNDADNASVLSVSSNFEPFATDDLGNT 1513
SE S AT+ K E E K+ E+ + + + + + +LG
Sbjct: 1151 SERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQ 1210
Query: 1514 VIHLDQALARM-REYERMKTE-----------AESNSNMRCTCRIIEDGDGAGAGTTVNN 1561
+ +L + ++ +E +K E ++S SN+ TCR +ED + +
Sbjct: 1211 IDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVED---QFSEIKAKD 1267
Query: 1562 LEETPVIENRSSQQPVSEVSTIPCP-RIDTQ-----QLDRQIKAIMKEVIPFLKEHMDEV 1615
++T +I + + Q+ + R++ + QL + +A+ ++ + LK M+E
Sbjct: 1268 EQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQ-LEELKRQMEEE 1326
Query: 1616 CSSQ-----LLTSVRRMVLTLTQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGE 1670
++ L S R L +Q +E +E +L L + ++ A + K
Sbjct: 1327 TKAKNAMAHALQSSRHDCDLLREQYEEEQE----AKAELQRALSKANSEVAQWRTK-YET 1381
Query: 1671 DLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGVIQSCAKEAKRILEDHGS 1730
D + E+ + + +Q+ + N+ T +C + +Q ++ R LE +
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHT 1441
Query: 1731 PAGEIDDEDKDKDE---------------------------TETVKQTQT-SEVYD---- 1758
+D + ++ D+ TE K EV D
Sbjct: 1442 ACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET 1501
Query: 1759 ---GPKNVRSDISDQEED--------EESEGCPVSINLSKAETQALTNYGSGEDENEDEE 1807
KN++ +ISD E +E+E + K++ Q G E+E+ +
Sbjct: 1502 LRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESK 1561
Query: 1808 MEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATSKND 1863
+ + V++ L + + E++E EQ L+R+ ++ AE+ L+ E S+ND
Sbjct: 1562 ILRVQLELSQVKSEL--DRKVIEKDEEIEQ-LKRNSQRAAEALQSVLDAEIRSRND 1614
Score = 32.3 bits (72), Expect = 4.8
Identities = 83/423 (19%), Positives = 171/423 (40%), Gaps = 78/423 (18%)
Query: 1609 KEHMDEVCSSQLLTSVRRMVLTLTQQNDE---SKEFVKFFHKQLGSILQDSLAKFAGRK- 1664
K ++++ CSS L + + LTLT+ E ++ VK +++ + L+++++K K
Sbjct: 944 KRNLEDKCSS-LKRDIDDLELTLTKVEKEKHATENKVKNLSEEM-TALEENISKLTKEKK 1001
Query: 1665 -LKDCGEDLL--VEISEVLFNELAFF--KLMQDLDNNSITVKQRCKRKIEATGVIQSCAK 1719
L++ + L +++ E N L KL Q D+ +++Q K + + +
Sbjct: 1002 SLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADL--------E 1053
Query: 1720 EAKRILEDHGSPAGE-IDDEDKDKDETETVKQTQTSEVYDGPKNVRSDISDQEEDEESEG 1778
AKR LE + E I D + DK + E + + E+ S + + +DE+
Sbjct: 1054 RAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFEL--------SQLQAKIDDEQVH- 1104
Query: 1779 CPVSINLSKAETQALTNYGSGEDENEDE----------------EMEEFEEGPVDVQTSL 1822
S+ K + E+E E E E+EE E + +
Sbjct: 1105 ---SLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGAT 1161
Query: 1823 QANTEATEENEHDEQVLQRDFKKTAESKNVPLEREATSKNDQNNCPVKPCYL-NILEDEQ 1881
A E ++ E + Q ++RD ++ L+ EAT+ + L +++ Q
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLEEAT------LQHEATAATLRKKQADSVAELGEQIDNLQ 1215
Query: 1882 PLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVKEVKSAQE------TPESSLAGS 1935
+ KE + L + + +M + + + KS E + S +
Sbjct: 1216 RVKQKLEKEK----------SELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKA 1265
Query: 1936 PDTESPVLVND-------YEAESGNISQKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEE 1988
D + L++D + ++G +S + +E++ + + K + + + K+ +EE
Sbjct: 1266 KDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEE 1325
Query: 1989 EQK 1991
E K
Sbjct: 1326 ETK 1328
Score = 32.0 bits (71), Expect = 6.3
Identities = 39/173 (22%), Positives = 70/173 (40%), Gaps = 22/173 (12%)
Query: 216 ITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPMEEIEN 275
IT A+ M E+L ++ + SA++ER+ +K+ + +K + R + E +
Sbjct: 1763 ITDAAMMAEELKKEQDTSAHLERM----------KKNLEQTVKDLQHRLDEAEQLALKGG 1812
Query: 276 LKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSIT 335
K+ L R+ + + +L Q R A L HK E+ + M + L
Sbjct: 1813 KKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNIL------ 1866
Query: 336 SELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQSRKPSASER 388
L DL+ + +++ + A + LS R V Q A+ER
Sbjct: 1867 -----RLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRV-QHELEEAAER 1913
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 55.8 bits (133), Expect = 4e-07
Identities = 155/797 (19%), Positives = 298/797 (37%), Gaps = 102/797 (12%)
Query: 142 NFLPMQINTNKSKDASTS---PPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEP 198
N P + T KS D +++ P + S+ C +L S S + L S G
Sbjct: 370 NSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPC-QLSPSGFSGEELPFVGFSYSKALGIL 428
Query: 199 AMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLK 258
S +VS L D K SSM + L+ K++ + + H ++ + + ++
Sbjct: 429 G-RSESVVSGL----DSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVE 483
Query: 259 KILARDPQQEPMEEIENLKKQHDL---------LKRMLQQQEQLRALQGRQAALLALQHK 309
+L++ + E + + DL LKR L+Q ++ Q AL L
Sbjct: 484 AVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQA-RMEVSQEDDKALQLLHDI 542
Query: 310 AEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQR---FHNQLRDSQPPAVPDNRR 366
EQ+ + + A + ++L E+L +R + ++LR+S+ A R+
Sbjct: 543 REQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRK 602
Query: 367 QAESLSLTREVSQSRKPSASERLPDEKVELFSKMRV--LQEKKQKMDKLLGELHTLRDQH 424
E + KP E EK+ ++++ LQEK +K K E L Q+
Sbjct: 603 ATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELL-QN 661
Query: 425 LNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHL 484
+ + +R +++ S S G+ LV E E E H
Sbjct: 662 IRQAKERAERELEKLQNREDS-SEGIRK------------------KLVEAEELE-EKHR 701
Query: 485 NPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEP 544
Q L L++ +YE+ ++ + + ++ D+ET E+ E +
Sbjct: 702 EAQVSAQHLEV------HLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHE 755
Query: 545 VTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCR 604
I + Q A + N D + + I S AN A N SL +
Sbjct: 756 KGKILSEQKA--------------MINAMDSKIRSLEQRIVELSEANKLAAN--SSLFTQ 799
Query: 605 YNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPED----AEFEQKIN 660
N + ++E+ + E +A + L + + D E E ++
Sbjct: 800 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLR 859
Query: 661 R--LMAAKQKL---RQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRG 715
L +QKL RQL +L +Q+ ++ + A+ + L+ + + T
Sbjct: 860 EVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES--QLRQAKTELEETTAE 917
Query: 716 NANKTQKDTGVNEKAREKFYEAK-----LQQQQRELKQLQEERKKLID----IQEKIQAL 766
+ Q T ++ + KF + + + +L QL E+ +L + + +++
Sbjct: 918 AEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEA 977
Query: 767 QTACPDLQLSAASVGNCP---TKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELW 823
A ++ + V + T++ M + T+ +T+ + + D +++EL
Sbjct: 978 SGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELL 1037
Query: 824 SEMRRHEMLREELRQRRKQLEALMAEHQRR------------QGLAETASPVAVSLRSDG 871
+ R+ E R L + Q E + E QR Q + E+ V ++++
Sbjct: 1038 EKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHK 1097
Query: 872 SENLCTPQQSRTEKTMA 888
+E L Q + +K A
Sbjct: 1098 AEILALQQALKEQKLKA 1114
Score = 39.3 bits (90), Expect = 0.040
Identities = 150/796 (18%), Positives = 300/796 (37%), Gaps = 144/796 (18%)
Query: 88 YMSQMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQ-LSENRKPFNFLPM 146
++ Q + +++ L +I D+ ++ + Q A+ K + LSE + N +
Sbjct: 713 HLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDS 772
Query: 147 QINTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIV 206
+I + + + S N+ S+ LF +N + EE ++
Sbjct: 773 KIRSLEQRIVELSEANKLAANSS----LFTQ-------RNMKAQEE------------MI 809
Query: 207 SRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQ 266
S L Q + Y+ + E ++ +E I H +K+ + L+ L R+
Sbjct: 810 SELRQQKFYLETQAGKLE------AQNRKLEEQLEKISHQDHSDKNRLLELETRL-REVS 862
Query: 267 QEPMEEIENLKKQHDLLKRMLQQQE-QLRALQGRQAALLALQHKAEQAIAVMDDSVVAET 325
E E+ LK+Q L+ LQ++E QL ALQ AA AL+ + QA ++++
Sbjct: 863 LEHEEQKLELKRQLTELQLSLQERESQLTALQ---AARAALESQLRQAKTELEET----- 914
Query: 326 AGSLSGVSITSELNEEL------NDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQ 379
T+E EE+ D IQR + LR+S + D Q L+
Sbjct: 915 ---------TAEAEEEIQALTAHRDEIQRKFDALRNS-CTVITDLEEQLNQLT------- 957
Query: 380 SRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQ--HLNNSSSSPQRSVD 437
++ EL ++ L ++ + E+ LR + HL +R +
Sbjct: 958 -----------EDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHL-------RREIT 999
Query: 438 QRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVR 497
+R S + + L V A E E + S + ++
Sbjct: 1000 EREMQLTSQKQTM-EALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFE 1058
Query: 498 KRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNPQVASTW 557
R+ EL+ ++ +Q+ + E+R+ E E+ +E + + + S
Sbjct: 1059 CRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLS 1118
Query: 558 NEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQ 617
+++N D ++ E+N R SL + E E + + +
Sbjct: 1119 DKLN------------DLEKKHAMLEMNAR------------SLQQKLETERELKQRLLE 1154
Query: 618 GEDDEEEEEEAEEEGV----SGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQ 673
+ +++ + ++ + G + R+ L+ D E++ + +++ + +K++
Sbjct: 1155 EQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKM-- 1212
Query: 674 DLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREK 733
+G IS + L DF A+ D Q + +G ++ ++D + + +
Sbjct: 1213 ------------EGTIS-QQTKLIDFLQAKMD--QPAKKKKGLFSRRKEDPALPTQVPLQ 1257
Query: 734 FYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVT 793
+ E KL L++E+ + +++E +Q + ++L +A K
Sbjct: 1258 YNELKL--------ALEKEKARCAELEEALQKTR-----IELRSAREEAAHRKATDHPHP 1304
Query: 794 STPTVNQHETSTSKSVFEPEDSSIVDNELW--SEMRRHEMLREELRQRRKQLEALMAEHQ 851
STP + + + S V PE + L S R+ EE +R K+ H+
Sbjct: 1305 STPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHR 1364
Query: 852 RRQGLAETASPVAVSL 867
GL A+ AV L
Sbjct: 1365 FNVGLNMRATKCAVCL 1380
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 55.5 bits (132), Expect = 5e-07
Identities = 175/900 (19%), Positives = 346/900 (38%), Gaps = 140/900 (15%)
Query: 89 MSQMSVPEQAELEKLKQRINFS---DLDQRSIGSDSQGRATAANNKRQLSENRKP----- 140
+ +M+ ++AELE+L+ ++ FS +L + + + R K L + K
Sbjct: 611 LDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGL 670
Query: 141 FNFLPMQINTNK-SKDASTSPPNRETIGSAQCKELFASALS----------NDLLQNCQV 189
N + +I T + KD + N+ + ++ K+L S ++ N+L + ++
Sbjct: 671 QNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730
Query: 190 ----SEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVE-KNERSANVERLTHLID 244
+E G E ++ Q+ + L++ + K + ++E + + E S + L D
Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLE-KQMKEKENDLQEKFAQLEAENSILKDEKKTLED 789
Query: 245 HLK----EQEKSYMKFLKKILARDPQQEPMEEIENL-KKQHDLLKRMLQQQEQLR----- 294
LK ++ + FL I ++ +EIE L ++ DL ++ +Q E++
Sbjct: 790 MLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNT 849
Query: 295 ---ALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEEL-----NDLI 346
A + + LQ + + V DD ++ L S LNEEL N
Sbjct: 850 FSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTT 909
Query: 347 QRFHNQLRDSQPPAVPDNRRQAE-------SLSLTREVSQSRKPSASERLPDEKVELFSK 399
+ + + D V + E L EV++ K S+RL D +L K
Sbjct: 910 VKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQK 969
Query: 400 ----------MRVLQEKKQKMDKLLGELHTL----RDQHLNNSSSSPQRSVDQRSTSAPS 445
++ L+++K+++ EL + R +++ + + +D T
Sbjct: 970 HGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSR 1029
Query: 446 ASVGLAPVVN---GESNSLTSSVPYPTASLVSQNESENE----GHL------------NP 486
+ G VN GE + + ++ ES+ E HL P
Sbjct: 1030 GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP 1089
Query: 487 SE--KLQK-LNEVRKRLNELR----------ELVH--YYEQTSDMMTDAVNENRKDE--- 528
SE KLQK LN ++ N+LR LV+ + +Q + M EN KD+
Sbjct: 1090 SENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYM-----ENEKDKALC 1144
Query: 529 ETEESEYDSEHENSEPVTNIRNPQVAS-TWNEVNSHSNAQCVSNNRDGRTVNSNCEINNR 587
+E ++ E + + I ++ + E + + + V+ C +
Sbjct: 1145 SLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQ 1204
Query: 588 SAANIRALNMPPSLDCRYNREGEQEI--HVAQGEDDEEEEEEAEEEGVSGASLSSHRSSL 645
+ ++ P+L C N E ++ ++++ ED E ++ E
Sbjct: 1205 TLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYE---------------- 1248
Query: 646 VDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEED 705
V + E+ +N++ KL LQ ++ + + NL P EE
Sbjct: 1249 VQDFQEN--MHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENL----PKEET 1302
Query: 706 TKQNSNNTRGNANKTQKDTGVNEKAR----EKFYEAKLQQQQRELKQLQEERKKLIDIQE 761
+ ++ N +D VN K++ + + KL++Q +EL+ L ++ + E
Sbjct: 1303 EFLSIHSQMTNL----EDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETE 1358
Query: 762 KIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNE 821
+ + C +L A S P + +V T + Q V + D +I +
Sbjct: 1359 QNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSG 1418
Query: 822 LWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQS 881
+ +++ +Q ++QLE +A+ +A A +S S G EN + +Q+
Sbjct: 1419 EFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIA-FAQQTELSRISGGKENTASSKQA 1477
Score = 49.7 bits (117), Expect = 3e-05
Identities = 166/925 (17%), Positives = 334/925 (36%), Gaps = 122/925 (13%)
Query: 190 SEEDGRGEPA---MESSQIVSRLVQIRDYITKASSMR-----EDLVEKNERSANVERLTH 241
SE+ + P M S++ + +I + + MR E L + E A +++
Sbjct: 146 SEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDG 205
Query: 242 LIDHLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLK---RMLQQQEQLRALQG 298
+I L + AR + E M E L +Q L+ + LQ E LR
Sbjct: 206 IITQLTANLQQ---------ARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTH 256
Query: 299 RQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQP 358
A LQ A+Q I + + L E+ + F Q+ Q
Sbjct: 257 SSTAADLLQ--AKQQILTHQQQLEEQ-----------DHLLEDYQKKKEDFTMQISFLQE 303
Query: 359 PAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELH 418
Q + + + + K + E L + +E K L++K DKLLGEL
Sbjct: 304 KIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQ 363
Query: 419 ---TLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQ 475
++Q + N S + S+ + V + + S + T +V +
Sbjct: 364 EQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDS-QFET-DIVQR 421
Query: 476 NESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEY 535
E E + +KL ++R L+E+ Y +Q M + + ++ E ++ +
Sbjct: 422 MEQETQ---------RKLEQLRAELDEM-----YGQQIVQMKQELIRQHMAQMEEMKTRH 467
Query: 536 DSEHENS-EPVTNIR-NPQVASTWNEVNSHSNAQCVSNNRD--------GRTVNSNCEIN 585
E EN+ +NI N N + N + N G + C +
Sbjct: 468 KGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ 527
Query: 586 NRSAANIRALNMPPSLDCRYNRE-GEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSS 644
+ + L+ R + EQE + + E+ + E VS S R
Sbjct: 528 RQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSA---SESRKE 584
Query: 645 LVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEE 704
L +H + KI M K+K + D +A Q+ + + S+ ++ +E
Sbjct: 585 LELKHEAEVT-NYKIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKE 642
Query: 705 DTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQ 764
D + R N K + + G++ K + + + ++++ +Q E+ LI Q ++
Sbjct: 643 DLEIEH---RINIEKLKDNLGIHYKQQ---IDGLQNEMSQKIETMQFEKDNLITKQNQLI 696
Query: 765 ALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWS 824
+ DLQ S + + T +N+ + E ++ ++ E+
Sbjct: 697 LEISKLKDLQQSLVN---------SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE 747
Query: 825 EMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASP-----VAVSLRSDGSENLCTPQ 879
+ E+L ++++++ L+ A+ + + + + + E L
Sbjct: 748 LQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLD 807
Query: 880 QSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSN-S 938
+++ + W + ++E D L + ++ +EE E+++ + FS N
Sbjct: 808 SIKSKSKDSVWEKEIEILIEENED----LKQQCIQLNEEIEKQR-----NTFSFAEKNFE 858
Query: 939 VNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQ 998
VN+ E Y L K + + ++ L + S+L + E E
Sbjct: 859 VNYQ-----------------ELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE-EL 900
Query: 999 WQEQINQLKKQLDFSV------SICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVH 1052
++IN ++ SV + +TL + + + + S ++
Sbjct: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960
Query: 1053 FIMHQLNQCYTQLTWQQNNVQRLKQ 1077
+ QL Q + ++++ V+ LKQ
Sbjct: 961 DLSEQLKQKHGEISFLNEEVKSLKQ 985
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 55.5 bits (132), Expect = 5e-07
Identities = 175/900 (19%), Positives = 346/900 (38%), Gaps = 140/900 (15%)
Query: 89 MSQMSVPEQAELEKLKQRINFS---DLDQRSIGSDSQGRATAANNKRQLSENRKP----- 140
+ +M+ ++AELE+L+ ++ FS +L + + + R K L + K
Sbjct: 611 LDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGL 670
Query: 141 FNFLPMQINTNK-SKDASTSPPNRETIGSAQCKELFASALS----------NDLLQNCQV 189
N + +I T + KD + N+ + ++ K+L S ++ N+L + ++
Sbjct: 671 QNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730
Query: 190 ----SEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVE-KNERSANVERLTHLID 244
+E G E ++ Q+ + L++ + K + ++E + + E S + L D
Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLE-KQMKEKENDLQEKFAQLEAENSILKDEKKTLED 789
Query: 245 HLK----EQEKSYMKFLKKILARDPQQEPMEEIENL-KKQHDLLKRMLQQQEQLR----- 294
LK ++ + FL I ++ +EIE L ++ DL ++ +Q E++
Sbjct: 790 MLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNT 849
Query: 295 ---ALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEEL-----NDLI 346
A + + LQ + + V DD ++ L S LNEEL N
Sbjct: 850 FSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTT 909
Query: 347 QRFHNQLRDSQPPAVPDNRRQAE-------SLSLTREVSQSRKPSASERLPDEKVELFSK 399
+ + + D V + E L EV++ K S+RL D +L K
Sbjct: 910 VKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQK 969
Query: 400 ----------MRVLQEKKQKMDKLLGELHTL----RDQHLNNSSSSPQRSVDQRSTSAPS 445
++ L+++K+++ EL + R +++ + + +D T
Sbjct: 970 HGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSR 1029
Query: 446 ASVGLAPVVN---GESNSLTSSVPYPTASLVSQNESENE----GHL------------NP 486
+ G VN GE + + ++ ES+ E HL P
Sbjct: 1030 GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP 1089
Query: 487 SE--KLQK-LNEVRKRLNELR----------ELVH--YYEQTSDMMTDAVNENRKDE--- 528
SE KLQK LN ++ N+LR LV+ + +Q + M EN KD+
Sbjct: 1090 SENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYM-----ENEKDKALC 1144
Query: 529 ETEESEYDSEHENSEPVTNIRNPQVAS-TWNEVNSHSNAQCVSNNRDGRTVNSNCEINNR 587
+E ++ E + + I ++ + E + + + V+ C +
Sbjct: 1145 SLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQ 1204
Query: 588 SAANIRALNMPPSLDCRYNREGEQEI--HVAQGEDDEEEEEEAEEEGVSGASLSSHRSSL 645
+ ++ P+L C N E ++ ++++ ED E ++ E
Sbjct: 1205 TLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYE---------------- 1248
Query: 646 VDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEED 705
V + E+ +N++ KL LQ ++ + + NL P EE
Sbjct: 1249 VQDFQEN--MHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENL----PKEET 1302
Query: 706 TKQNSNNTRGNANKTQKDTGVNEKAR----EKFYEAKLQQQQRELKQLQEERKKLIDIQE 761
+ ++ N +D VN K++ + + KL++Q +EL+ L ++ + E
Sbjct: 1303 EFLSIHSQMTNL----EDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETE 1358
Query: 762 KIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNE 821
+ + C +L A S P + +V T + Q V + D +I +
Sbjct: 1359 QNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSG 1418
Query: 822 LWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQS 881
+ +++ +Q ++QLE +A+ +A A +S S G EN + +Q+
Sbjct: 1419 EFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIA-FAQQTELSRISGGKENTASSKQA 1477
Score = 49.7 bits (117), Expect = 3e-05
Identities = 166/925 (17%), Positives = 334/925 (36%), Gaps = 122/925 (13%)
Query: 190 SEEDGRGEPA---MESSQIVSRLVQIRDYITKASSMR-----EDLVEKNERSANVERLTH 241
SE+ + P M S++ + +I + + MR E L + E A +++
Sbjct: 146 SEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDG 205
Query: 242 LIDHLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLK---RMLQQQEQLRALQG 298
+I L + AR + E M E L +Q L+ + LQ E LR
Sbjct: 206 IITQLTANLQQ---------ARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTH 256
Query: 299 RQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQP 358
A LQ A+Q I + + L E+ + F Q+ Q
Sbjct: 257 SSTAADLLQ--AKQQILTHQQQLEEQ-----------DHLLEDYQKKKEDFTMQISFLQE 303
Query: 359 PAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELH 418
Q + + + + K + E L + +E K L++K DKLLGEL
Sbjct: 304 KIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQ 363
Query: 419 ---TLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQ 475
++Q + N S + S+ + V + + S + T +V +
Sbjct: 364 EQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDS-QFET-DIVQR 421
Query: 476 NESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEY 535
E E + +KL ++R L+E+ Y +Q M + + ++ E ++ +
Sbjct: 422 MEQETQ---------RKLEQLRAELDEM-----YGQQIVQMKQELIRQHMAQMEEMKTRH 467
Query: 536 DSEHENS-EPVTNIR-NPQVASTWNEVNSHSNAQCVSNNRD--------GRTVNSNCEIN 585
E EN+ +NI N N + N + N G + C +
Sbjct: 468 KGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ 527
Query: 586 NRSAANIRALNMPPSLDCRYNRE-GEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSS 644
+ + L+ R + EQE + + E+ + E VS S R
Sbjct: 528 RQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSA---SESRKE 584
Query: 645 LVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEE 704
L +H + KI M K+K + D +A Q+ + + S+ ++ +E
Sbjct: 585 LELKHEAEVT-NYKIKLEMLEKEK-NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKE 642
Query: 705 DTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQ 764
D + R N K + + G++ K + + + ++++ +Q E+ LI Q ++
Sbjct: 643 DLEIEH---RINIEKLKDNLGIHYKQQ---IDGLQNEMSQKIETMQFEKDNLITKQNQLI 696
Query: 765 ALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWS 824
+ DLQ S + + T +N+ + E ++ ++ E+
Sbjct: 697 LEISKLKDLQQSLVN---------SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE 747
Query: 825 EMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASP-----VAVSLRSDGSENLCTPQ 879
+ E+L ++++++ L+ A+ + + + + + E L
Sbjct: 748 LQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLD 807
Query: 880 QSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSN-S 938
+++ + W + ++E D L + ++ +EE E+++ + FS N
Sbjct: 808 SIKSKSKDSVWEKEIEILIEENED----LKQQCIQLNEEIEKQR-----NTFSFAEKNFE 858
Query: 939 VNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQ 998
VN+ E Y L K + + ++ L + S+L + E E
Sbjct: 859 VNYQ-----------------ELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE-EL 900
Query: 999 WQEQINQLKKQLDFSV------SICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVH 1052
++IN ++ SV + +TL + + + + S ++
Sbjct: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960
Query: 1053 FIMHQLNQCYTQLTWQQNNVQRLKQ 1077
+ QL Q + ++++ V+ LKQ
Sbjct: 961 DLSEQLKQKHGEISFLNEEVKSLKQ 985
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 55.1 bits (131), Expect = 7e-07
Identities = 192/984 (19%), Positives = 354/984 (35%), Gaps = 148/984 (15%)
Query: 154 KDASTSPPNRETIGSAQCKELFAS--ALSNDLL--QNCQVSEEDGRGEPAMESSQIVSRL 209
K STS N+ + L A AL + LL Q+ S G G PA +S +
Sbjct: 90 KQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYG 149
Query: 210 VQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEP 269
+ M D + + RL++ + L+ + + + A+
Sbjct: 150 ISHHPSAFHDDDM--DFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSD 207
Query: 270 MEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSL 329
EI L+ +++K + Q + Q + Q + LQ+ +Q +
Sbjct: 208 QSEICKLQ---NIIKELKQNRSQ--EIDDHQHEMSVLQNAHQQKLT-------------- 248
Query: 330 SGVSITSELNEELNDL---IQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQSRKPSAS 386
I+ EEL+D I+ N L+ + + + + T +V Q
Sbjct: 249 ---EISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQI------ 299
Query: 387 ERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSA 446
EKVE KM L++K + ++K L RD Q +V++R
Sbjct: 300 -----EKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQE---QLNVEKRQIMEEC- 350
Query: 447 SVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRL----NE 502
E+ L S P+A S +E E L S ++++ +++ L NE
Sbjct: 351 ----------ENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENE 400
Query: 503 LRELVHYYEQTSDMMTDAVNENRKDE--ETEESEYDSEHENSE----PVTNIRNPQVAST 556
+ L Q + + D + + E E E+S E E + + N ++
Sbjct: 401 IMRLSSL-NQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTA 459
Query: 557 WNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSA--ANIRALNMPPSLDCRYNREGEQEIH 614
+++ S + N + + N I+ + A I L+ ++ + ++
Sbjct: 460 TRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLS 519
Query: 615 VAQGEDDE---EEEEEAEEEGVSGASLSSHRSSLVDEHPEDAE----FEQKINRLMAAKQ 667
Q E D + +++ +E L + + E E E +N L KQ
Sbjct: 520 KQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQ 579
Query: 668 KLR-QLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNT-----RGNANKTQ 721
KL ++++LV + + I L + E+ N ++N
Sbjct: 580 KLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNF 639
Query: 722 KDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKL-IDIQEKIQALQTACPDL--QLSAA 778
KDT + E+ E L+Q EL+QL E KK+ D++ + + L AC D+ QL
Sbjct: 640 KDTLLKEREAEV---RNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEEC 696
Query: 779 SVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQ 838
GN + T + + E + L E ++E EEL
Sbjct: 697 LAGNNQLSLEKNTIVETLKMEKGEIEA--------ELCWAKKRLLEEANKYEKTIEELSN 748
Query: 839 RRK-QLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCA 897
R AL EH+ ++ + +++ + + + M T T+
Sbjct: 749 ARNLNTSALQLEHEHL-------------IKLNQKKDMEIAELKKNIEQMDTDHKETKDV 795
Query: 898 LDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNC 957
L +E L++ I + + E+ ++ SS + + Y+ KN
Sbjct: 796 LSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEEL--------DKYSQALRKNEILRQ- 846
Query: 958 PFSADENYRPLAKTRQQNISMQ------RQENLRWV-----SELSYVEEKEQWQEQINQL 1006
+ +E R L +++N +Q R+E R L V E Q+N +
Sbjct: 847 --TIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTI 904
Query: 1007 KKQLDFSVSICQTLMQDQ-QTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQL 1065
K+ L+ + Q +++DQ Q+ LLQ S+ + + Q+N +TQL
Sbjct: 905 KEHLEEEIKHHQKIIEDQNQSKMQLLQ-------SLQEQKKEMDEFRYQHEQMNATHTQL 957
Query: 1066 TWQ--------QNNVQRLKQMLNE 1081
+ Q ++++K L+E
Sbjct: 958 FLEKDEEIKSLQKTIEQIKTQLHE 981
Score = 47.8 bits (112), Expect = 1e-04
Identities = 173/898 (19%), Positives = 352/898 (39%), Gaps = 114/898 (12%)
Query: 182 DLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERL-- 239
+L QN +D + E ++ + +L +I + RE+L + ER +E L
Sbjct: 220 ELKQNRSQEIDDHQHEMSVLQNAHQQKLTEI------SRRHREELSDYEERIEELENLLQ 273
Query: 240 --------THLIDHLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQ-------HDLLK 284
T L + Q+ + ++K+ + ++ ++I+++ K+ D+L+
Sbjct: 274 QGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILR 333
Query: 285 RMLQQQEQLRALQGR---QAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSE---L 338
R +QEQL + + + L L+ Q AV + E L+ + E L
Sbjct: 334 R---EQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRL 390
Query: 339 NEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFS 398
+ L+D +Q ++ ++ + + E +S E L ++L +
Sbjct: 391 QQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNN 450
Query: 399 KMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGES 458
+ V++ + L ELH LR +L +S+ ++ T + ++ ++
Sbjct: 451 EYEVIKSTATRDISLDSELHDLR-LNLEAKEQELNQSISEKETL-----IAEIEELDRQN 504
Query: 459 NSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRE------------- 505
T + L Q +NEG S+ Q LN+ +KR+++L +
Sbjct: 505 QEATKHMILIKDQLSKQ---QNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQK 561
Query: 506 --------LVHYYEQTSDMMTDAVNENRKDE--ETEESEYDSEHENSEPVTNIR--NPQV 553
++ T + D V EN D+ +++ES + EN E +IR ++
Sbjct: 562 EKLIQSEVALNDLHLTKQKLEDKV-ENLVDQLNKSQESNVSIQKENLELKEHIRQNEEEL 620
Query: 554 ASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINN--RSAANIRALNMPPSLDCRYNREGEQ 611
+ NE+ N SN +D E+ N ++ + + LN ++ + E
Sbjct: 621 SRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLN-ENLKKVAFDVKMEN 679
Query: 612 EIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDE-HPEDAEFEQKINRLMAAKQKLR 670
E V ED + EE LS ++++V+ E E E ++ A K+ L
Sbjct: 680 EKLVLACEDVRHQLEECL---AGNNQLSLEKNTIVETLKMEKGEIEAEL--CWAKKRLLE 734
Query: 671 QLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKA 730
+ +++ A+ ++ SA L+ + + + K++ N Q DT + K
Sbjct: 735 EANKYEKTIEELSNARN-LNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDT--DHKE 791
Query: 731 REKFYEAKLQQQQRELKQLQEERKKLID-IQEKIQALQTACPDLQ--LSAASVGNCPTKK 787
+ + L ++Q++L QL +++ I+ ++E+ LQ L + ++
Sbjct: 792 TKDVLSSSL-EEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEE 850
Query: 788 YMPAVTSTPTVNQH----------ETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELR 837
++ S N H E S + V +P+ V EL SE+ + ++E L
Sbjct: 851 KDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSV-TELASEVSQLNTIKEHLE 909
Query: 838 QRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCA 897
+ K + ++ + ++ + SL+ E + + E+ AT TQ
Sbjct: 910 EEIKHHQKIIEDQN------QSKMQLLQSLQEQKKE--MDEFRYQHEQMNAT---HTQLF 958
Query: 898 LDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNH-NSYNGKETKNRWKNN 956
L E+ +E L + I + + EE+ DN + V N NG E K++
Sbjct: 959 L-EKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSE-----KHD 1012
Query: 957 CPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQEQINQLKKQLDFSV 1014
+ E K R+ I + ++N+ ++ + + E ++ Q+ +Q D +
Sbjct: 1013 LSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDE--VGKLTQIIQQKDLEI 1068
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 54.7 bits (130), Expect = 9e-07
Identities = 150/762 (19%), Positives = 276/762 (36%), Gaps = 143/762 (18%)
Query: 195 RGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNER-------------------SAN 235
RG E Q+ S + ++ I+ S +E+L + ++ +A
Sbjct: 454 RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNAT 513
Query: 236 VERLTHLIDHLKEQEKSYMKFLKKILARDPQ-----QEPMEEIEN-LKKQHDLLKRMLQQ 289
+++ + LK+Q K L + L + Q + +E++ + LK++ LK + ++
Sbjct: 514 IQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEK 573
Query: 290 QEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRF 349
QE R +Q A A + +A S+ A ++ E +L L Q+
Sbjct: 574 QEATRQDHAQQLATAAEEREA---------SLRERDAALKQLEALEKEKAAKLEILQQQL 624
Query: 350 H--NQLRDSQPPAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKV---ELFSKMRVLQ 404
N+ RDS +V +R+ LS E Q+ +A + + + EL ++R Q
Sbjct: 625 QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ 684
Query: 405 EKKQKMDKLLGELHTLRDQ--HLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLT 462
+K + +++ E L++Q L S + S+++ A A E
Sbjct: 685 QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALE--------EQQRCI 736
Query: 463 SSVPYPTASLVSQN-------ESENEGHLNPSEKLQKLNE--------VRKRLNELRELV 507
S + T SLV Q+ E E G +LQ+L E +R+ L E
Sbjct: 737 SELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQ 796
Query: 508 HYYEQTSDMMTDAV---NENRKDEETEESEYDS-----------EHENSEPVTNIRNPQV 553
H E + + V E +D + EE++Y + E E + +V
Sbjct: 797 HTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKV 856
Query: 554 ASTWNEVNSHSNAQCVSNNRDGRTVNSNCE--INNRSAANIRALNMPPSLDCRYNREGEQ 611
A + SHS Q + +++N + +RA + L +
Sbjct: 857 AG----IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAAT 912
Query: 612 EIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQ 671
VA+ E + E +E + L + D PE E +Q+ RQ
Sbjct: 913 SKEVARLETLVRKAGEQQE--TASRELVKEPARAGDRQPEWLE-----------EQQGRQ 959
Query: 672 LQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAR 731
A +Q E + +Q N + G ++ R
Sbjct: 960 FCSTQAALQ--------------------AMEREAEQMGNELERLRAALMESQGQQQEER 999
Query: 732 EKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPA 791
QQ+RE+ +L +ER + Q + + A +L++ + N ++
Sbjct: 1000 G--------QQEREVARLTQERGRA---QADLALEKAARAELEMRLQNALNEQRVEF--- 1045
Query: 792 VTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEH- 850
+T T K + E + + E ++++ E LR+ ++Q ++QL EH
Sbjct: 1046 --ATLQEALAHALTEKEGKDQELAKLRGLEA-AQIKELEELRQTVKQLKEQLAKKEKEHA 1102
Query: 851 ------QRRQGLAETASPVAVSLRSDGS--ENLCTPQQSRTE 884
G E P +LR++ S E C QQ + +
Sbjct: 1103 SGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144
Score = 52.4 bits (124), Expect = 5e-06
Identities = 162/873 (18%), Positives = 320/873 (36%), Gaps = 145/873 (16%)
Query: 23 ENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTPHT 82
+ + ++L + + K + EK + +E +R +++ E+ V + + +
Sbjct: 698 DQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKEL 757
Query: 83 FPH-------SRYMSQMSVPEQAELEKLKQRINFSDLDQRSIGSDSQG--RATAANNKRQ 133
+ Q+ QAE E L++ + + Q + S+ + + AA +R
Sbjct: 758 EEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERY 817
Query: 134 LSENRKPFNFLPM---QINTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVS 190
++ + M Q+ T K + +E KE A S+ LQ +S
Sbjct: 818 EDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEA------KEKVAGIESHSELQ---IS 868
Query: 191 EEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNER----SANVERLTHLIDHL 246
+ + E A + + L Q+++ +A + +DL E+ S V RL L+
Sbjct: 869 RQ--QNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKA 926
Query: 247 KEQEKSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLAL 306
EQ+++ + L K AR ++P E +E ++Q R QAAL A+
Sbjct: 927 GEQQETASRELVKEPARAGDRQP-EWLE---------------EQQGRQFCSTQAALQAM 970
Query: 307 QHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRR 366
+ +AEQ + + ++R L +SQ + +
Sbjct: 971 EREAEQ-----------------------------MGNELERLRAALMESQGQQQEERGQ 1001
Query: 367 QAESLS-LTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGEL-HTLRDQH 424
Q ++ LT+E +++ A E+ ++E+ L E++ + L L H L ++
Sbjct: 1002 QEREVARLTQERGRAQADLALEKAARAELEM-RLQNALNEQRVEFATLQEALAHALTEKE 1060
Query: 425 LNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHL 484
+ + R GL E L +V L + + G
Sbjct: 1061 GKDQELAKLR--------------GLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSG 1106
Query: 485 NPSEKLQKLNEVRKRLNELRELVHYYE---QTSDMMTDAVNENRKDEETEESEYDSEHEN 541
SE + +L LR V E Q D++ + + E +E DS E
Sbjct: 1107 AQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALET 1166
Query: 542 SEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSL 601
+ + ++ HS + S R+ + + ++++
Sbjct: 1167 LQGQLEEKAQEL--------GHSQSALASAQRELAAFRTKVQDHSKA------------- 1205
Query: 602 DCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINR 661
E E + VA+G +EAE + +SL S L + E +++ R
Sbjct: 1206 ------EDEWKAQVARG------RQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKR 1253
Query: 662 L-MAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTR-GNANK 719
L MA +K ++L++ + ++Q + A+ +A S+ + ++ + R + N
Sbjct: 1254 LVMAESEKSQKLEERLRLLQAETASNSARAAERSSA--LREEVQSLREEAEKQRVASENL 1311
Query: 720 TQKDTGVNEKARE-----KFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQ 774
Q+ T E+A E K ++ K Q+++ L LQ E + ++ + C LQ
Sbjct: 1312 RQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQ 1371
Query: 775 LSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFE--PEDSSIVDNELWSEMRRHEML 832
A+ ++ + + + + + E P + + E R + L
Sbjct: 1372 AEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQE-----RTAQQL 1426
Query: 833 REELRQRRKQLEALMAEH----QRRQGLAETAS 861
R E +QL L H + +GL E A+
Sbjct: 1427 RAEKASYAEQLSMLKKAHGLLAEENRGLGERAN 1459
Score = 45.4 bits (106), Expect = 6e-04
Identities = 131/655 (20%), Positives = 250/655 (38%), Gaps = 76/655 (11%)
Query: 138 RKPFNFLPMQINTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQ--------- 188
++ FL +Q K AS+S N GS ++ D+LQ Q
Sbjct: 176 KREIRFLELQ------KVASSSSGNNFLSGSP-------ASPMGDILQTPQFQMRRLKKQ 222
Query: 189 -VSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLK 247
E R E +E ++ L + I + L NE+ A ++ L+
Sbjct: 223 LADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELR 282
Query: 248 EQEKSYMKFLKKIL--ARDPQQEPME---EIENLKKQH-DLLKRMLQQQEQLRALQGRQA 301
++ +S L + L +D + E + +I L +++ DL ++ + L+ LQ
Sbjct: 283 DKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALN 342
Query: 302 ALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFH---NQLRDSQP 358
L KA Q + E + +L E NE L + + +QL+D+ P
Sbjct: 343 ELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPP 402
Query: 359 PAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQ-EKKQKMDKLLGEL 417
+ + E L ++ ++ +A+ L +L +++ +L+ E+ Q+ KLL E
Sbjct: 403 ------QEKGEVLGDVLQLETLKQEAAT--LAANNTQLQARVEMLETERGQQEAKLLAER 454
Query: 418 HTLRD--QHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQ 475
+ Q L++ + Q S+ S A L LT+ V ASL S+
Sbjct: 455 GHFEEEKQQLSSLITDLQSSISNLS----QAKEELEQASQAHGARLTAQV----ASLTSE 506
Query: 476 NESENEGHLNPSEKLQKLNE-VRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESE 534
+ N ++L L + +++ +L + + EQ S + V + + +E +
Sbjct: 507 LTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQ 566
Query: 535 YDSEHENSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRA 594
E E Q+A+ E + RD + AA +
Sbjct: 567 LKEVAEKQEATRQDHAQQLATAAEE------REASLRERDAALKQLEA-LEKEKAAKLEI 619
Query: 595 LNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAE 654
L L + V Q + ++ E EE A + + R ++H A+
Sbjct: 620 LQQ--QLQVANEARDSAQTSVTQAQREKAELSRKVEE--LQACVETARQ---EQHEAQAQ 672
Query: 655 FEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTR 714
+ +L + +QK + + + Q+ D Q + A +L + E+ K+ +
Sbjct: 673 VAELELQLRSEQQKATEKE---RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRA---- 725
Query: 715 GNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTA 769
+A + Q+ KA + + ++Q +RE K+L+EER ++ ++Q L A
Sbjct: 726 ADALEEQQRCISELKAETR---SLVEQHKRERKELEEERAGRKGLEARLQQLGEA 777
Score = 45.4 bits (106), Expect = 6e-04
Identities = 108/543 (19%), Positives = 207/543 (38%), Gaps = 77/543 (14%)
Query: 485 NPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEP 544
N E +L E RK L E + +Q D + +NE + E E + + +E
Sbjct: 229 NRDELELELAENRKLLTEKDAQIAMMQQRIDRLA-LLNEKQAASPLEPKELEELRDKNES 287
Query: 545 VTNIRNPQVASTWNEVNSHSNA-QCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDC 603
+T + H QC +D +T S + R + N S
Sbjct: 288 LT-------------MRLHETLKQC----QDLKTEKSQMD---RKINQLSEENGDLSFKL 327
Query: 604 RYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLM 663
R Q++ A E EE + +E A L S+ + +D + ++ N ++
Sbjct: 328 REFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAAL----QDKKCLEEKNEIL 383
Query: 664 AAKQKLRQLQDLVAMVQDDDAAQ-GVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQK 722
K L QL++ ++ +QD+ + G + L+ +E +NNT+ A
Sbjct: 384 QGK--LSQLEEHLSQLQDNPPQEKGEVLGDVLQLETL--KQEAATLAANNTQLQARVEML 439
Query: 723 DTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLI-DIQEKIQALQTACPDLQLSAASVG 781
+T E+ ++ EAKL ++ ++ +++ LI D+Q I L A +L+ ++ + G
Sbjct: 440 ET---ERGQQ---EAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHG 493
Query: 782 NCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRK 841
T + + ++TS E +T + + +D + L+++ ++++
Sbjct: 494 ARLTAQ-VASLTS-------ELTTLNATIQQQDQELAG------------LKQQAKEKQA 533
Query: 842 QL-EALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE 900
QL + L + Q QGL ++ SL+ + + EK AT Q
Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQ-----LKEVAEKQEATRQDHAQQLATA 588
Query: 901 EGDEDGYLSEGIVRTDEEEEEEQDASSNDNF---SVCPSNSVNHNSYNGKETKNRWKNNC 957
+ + L E + E E++ ++ + +N ++ R K
Sbjct: 589 AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAEL 648
Query: 958 PFSADENYRPLAKTRQQNISMQ----------RQENLRWVSELSYVEEKEQWQEQINQLK 1007
+E + RQ+ Q R E + + +EK+Q QEQ+ LK
Sbjct: 649 SRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALK 708
Query: 1008 KQL 1010
+ L
Sbjct: 709 ESL 711
Score = 40.4 bits (93), Expect = 0.018
Identities = 149/756 (19%), Positives = 273/756 (36%), Gaps = 127/756 (16%)
Query: 165 TIGSAQCKELFASALSNDL------LQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITK 218
T + Q E A + N+L L Q +++ RG+ E V+RL Q R
Sbjct: 963 TQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQERE----VARLTQER----- 1013
Query: 219 ASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPMEEIENLKK 278
+ DL E++A E L + L EQ + + + ++E ++ L K
Sbjct: 1014 -GRAQADLAL--EKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQ--ELAK 1068
Query: 279 QHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSE- 337
L +++ E+LR + LA + K + +E AG E
Sbjct: 1069 LRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHAS----GSGAQSEAAGRTEPTGPKLEA 1124
Query: 338 LNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELF 397
L E++ L Q+ Q + QA+SL + E ++ + L + +L
Sbjct: 1125 LRAEVSKLEQQCQKQ------------QEQADSLERSLEAERASRAERDSALETLQGQLE 1172
Query: 398 SKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPVVNGE 457
K + L + + EL R + ++S + + A V
Sbjct: 1173 EKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWK----------AQVARGRQEAER 1222
Query: 458 SNSLTSSVPYPTASLVSQNESENEGH--------LNPSEKLQKLNEVRKRLN-ELRELVH 508
NSL SS+ S++++ E EG + SEK QKL E + L E
Sbjct: 1223 KNSLISSLE-EEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSA 1281
Query: 509 YYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRNP----QVASTWNEVNSHS 564
+ S + + V R EE E+ SE+ E + Q W E
Sbjct: 1282 RAAERSSALREEVQSLR--EEAEKQRVASENLRQELTSQAERAEELGQELKAWQE-KFFQ 1338
Query: 565 NAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEE 624
Q +S ++ + S + + +P C Q++ Q ++
Sbjct: 1339 KEQALST----------LQLEHTSTQALVSELLPAKHLC-------QQLQAEQAAAEKRH 1381
Query: 625 EEEAEEE-----GVSGASLSSHRS--SLVDEHPEDAEFEQKINRLMAAK----QKLRQLQ 673
EE E+ G+ L + R L+ + AE E+ +L A K ++L L+
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
Query: 674 DLVAMVQDDDAAQGVISASASNLD-DFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKARE 732
++ +++ G +NL F E D + A + +T + E RE
Sbjct: 1442 KAHGLLAEENRGLG----ERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQRE 1497
Query: 733 KF------------YEAKLQQQQRELKQLQEERKKL------IDIQEKIQALQTACPDLQ 774
YE + E ++ QEER+KL +++ ++ Q Q +
Sbjct: 1498 AQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKK 1557
Query: 775 LSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLR- 833
L+ + + ++ + AV + +Q E ++ + + E +E + +M +
Sbjct: 1558 LADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKA 1617
Query: 834 -----------EELRQRRKQLEALMAEHQRRQGLAE 858
+EL+++ + LE L E++ + AE
Sbjct: 1618 KTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAE 1653
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 54.7 bits (130), Expect = 9e-07
Identities = 139/716 (19%), Positives = 277/716 (38%), Gaps = 85/716 (11%)
Query: 190 SEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNE-RSANVERLTHLIDHLKE 248
+E R + + S + L +I + + +A VE N+ R A ++L ++
Sbjct: 1127 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATL 1186
Query: 249 QEKSYMKFLKKILARDPQQEPMEEIENLKK-QHDLLKRMLQQQEQLRALQGRQAALLALQ 307
Q ++ + L+K A D E E+I+NL++ + L K + + + L A+ +
Sbjct: 1187 QHEAMVAALRKKHA-DSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAK 1245
Query: 308 HKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQ 367
E+ ++D V S EE LI Q Q A +R+
Sbjct: 1246 GNLEKMCRSLEDQV-----------SELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQL 1294
Query: 368 AESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNN 427
E +L ++S+S++ S ++++ + K +L + + + + LR+Q+
Sbjct: 1295 DEKDALVSQLSRSKQAS-TQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEE 1353
Query: 428 SSSSPQRSVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASL-VSQNESENEGHLNP 486
+ QR+ S ++ V E++++ + A ++Q E E H+
Sbjct: 1354 QEGKAEL---QRALSKANSEVAQWRT-KYETDAIQRTEELEEAKKKLAQRLQEAEEHVEA 1409
Query: 487 -SEKLQKLNEVRKRL-NELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEP 544
+ K L + ++RL NE+ +L+ E+ S+ A+++ +++ + SE+ ++E ++
Sbjct: 1410 VNAKCASLEKTKQRLQNEVEDLMLDVER-SNAACAALDKKQRNFDKVLSEWKQKYEETQA 1468
Query: 545 VTNIRNPQVASTWNEVNSHSNA--QCVSNNRDGRTVNSNC--EINNRSAANIRALNMPPS 600
+ S E+ N + + R N N EI++ +
Sbjct: 1469 ELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHE 1528
Query: 601 LDCRYNREGEQEIHVAQGEDDEEEEEEAEEEG------VSGASLSSHRSSLVDEHPE--- 651
L+ + ++ EQE Q +E E EEG + + S + E E
Sbjct: 1529 LE-KIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1587
Query: 652 -----------------DAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDA---------- 684
DAE + + L K+ L ++ + +
Sbjct: 1588 QLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYR 1647
Query: 685 -AQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQ 743
QG++ + +LDD +ED K+ AN Q + E+ + A L+Q +
Sbjct: 1648 NTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEI-------EELW-ATLEQTE 1699
Query: 744 RELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHET 803
R K ++E L+D E++Q L T L + KK V+ + +
Sbjct: 1700 RSRKIAEQE---LLDASERVQLLHTQNTSLINT--------KKKLENDVSQLQSEVEEVI 1748
Query: 804 STSKSVFEPEDSSIVDNELWS-EMRRHEMLREELRQRRKQLEALMAEHQRRQGLAE 858
S++ E +I D + + E+++ + L + +K LE + + Q R AE
Sbjct: 1749 QESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1804
Score = 52.8 bits (125), Expect = 3e-06
Identities = 156/814 (19%), Positives = 303/814 (37%), Gaps = 116/814 (14%)
Query: 284 KRMLQQQEQLRALQGRQAALLALQH-----------------KAEQAIAVMDDSVVAETA 326
++MLQ++E L +Q A + ++H + E+ +A M +
Sbjct: 805 QKMLQRREALFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKD 864
Query: 327 GSLSGVSITSELNEELNDLIQRFHN-QLR-DSQPPAVPDNRRQAESLSLTREVSQSRKPS 384
+ EL E++ L++ ++ QL+ S+ ++ D + E L + +++
Sbjct: 865 ELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKE 924
Query: 385 ASERLPDEK---VELFSKMRVLQEKKQKMDKLLGELHTL-----RDQHLNNSS----SSP 432
+ER +E+ EL +K R L+++ ++ K + +L +++H + +
Sbjct: 925 VTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 984
Query: 433 QRSVDQRSTSAPSASVGLAPVVNGESNSLTS-----SVPYPTASLVSQNESENEGHLNPS 487
+D+ L + L + ++ + + Q + EG L
Sbjct: 985 MAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQE 1044
Query: 488 EKLQKLNEVRKRLNELRELVHYYEQTSDMMTDA--VNENRKDEETEESEYDSEHENSEPV 545
+KL+ E KR E +L E T DM D ++E + +E E S S+ E+ + V
Sbjct: 1045 KKLRMDLERAKRKLE-GDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAV 1103
Query: 546 T---NIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLD 602
+ ++ + E+ A+ S + + + + + S
Sbjct: 1104 EIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQ 1163
Query: 603 CRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQKINRL 662
N++ E E + + EE + E + A H S+ AE ++I+ L
Sbjct: 1164 VELNKKREAEFQKLRRD---LEEATLQHEAMVAALRKKHADSM-------AELGEQIDNL 1213
Query: 663 MAAKQKLRQLQDLVAMVQDDDAAQG-VISASASNLDDFYPAEED------TKQNSNNTRG 715
KQKL + + + M DD ++ IS + NL+ + ED TK+
Sbjct: 1214 QRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLI 1273
Query: 716 NANKTQ-----------------KDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLID 758
N Q KD V++ +R K +A QQ + QL+EE K
Sbjct: 1274 NDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSK--QASTQQIEELKHQLEEETKAKNA 1331
Query: 759 IQEKIQALQTACPDL--QLSAASVGNCPTKKYMPAVTSTPTV--NQHETSTSKSVFEPED 814
+ +Q+ + C L Q G ++ + S ++ET + E E+
Sbjct: 1332 LAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEE 1391
Query: 815 SSIVDNELWSEMRRHEMLREELRQRRKQLEALMAE----HQRRQGLAETASPVAVSL-RS 869
+ + L + L++ + +EA+ A+ + +Q L + + + RS
Sbjct: 1392 AK-------------KKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERS 1438
Query: 870 DGSENLCTPQQSRTEKTMATWG---GSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQD-- 924
+ + +Q +K ++ W TQ L+ E LS + + EE D
Sbjct: 1439 NAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQL 1498
Query: 925 ---ASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQ 981
N N S+ + GK+ K E A + S++ +
Sbjct: 1499 ETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVE-QEKCEIQAALEEAEASLEHE 1557
Query: 982 EN--LRWVSELSYVEEK-----EQWQEQINQLKK 1008
E LR EL+ V+ + + E+I+QLK+
Sbjct: 1558 EGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1591
Score = 34.3 bits (77), Expect = 1.3
Identities = 88/474 (18%), Positives = 180/474 (37%), Gaps = 53/474 (11%)
Query: 1589 DTQQLDRQIKAIMKEVIPFLKEHMDE-VCSSQLLTSVRRMVLTLTQQNDE--SKEFVKFF 1645
D QQLD +++ E+ + + DE QL ++ + + + +E ++ +
Sbjct: 1075 DKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAK 1134
Query: 1646 HKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVK---- 1701
++ S L L + + R L++ G ++ E F KL +DL+ ++ +
Sbjct: 1135 AEKQRSDLSRELEEISER-LEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVA 1193
Query: 1702 --------------------QRCKRKIEATGVIQSCAKEAKRILEDHGSPAGEIDDEDKD 1741
QR K+K+E E K +D S A I +
Sbjct: 1194 ALRKKHADSMAELGEQIDNLQRVKQKLEKE------KSELKMETDDLSSNAEAISKAKGN 1247
Query: 1742 KDETETVKQTQTSEVY---DGPKNVRSDISDQEEDEESEGCPVSINLSKAETQALTNYGS 1798
++ + Q SE+ + + + +D++ Q ++E S L E AL + S
Sbjct: 1248 LEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLD--EKDALVSQLS 1305
Query: 1799 GEDENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDFKKTAESKNVPLEREA 1858
+ +++EE + + + A A + + HD +L+ +++ E K L+R
Sbjct: 1306 RSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGK-AELQRAL 1364
Query: 1859 TSKNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRV 1918
+ N + + ++ + L A K + ++ + + + +E R+
Sbjct: 1365 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRL 1424
Query: 1919 K-EVKSAQETPESSLAGSPDTESPVLVND---------YEAESGNISQKSDEEDFVKVED 1968
+ EV+ E S A + D YE + E + E
Sbjct: 1425 QNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTEL 1484
Query: 1969 LPLKLTIYSEADLRKKMVEEEQKNHLSGEICEMQTEELAGNSETLKEPETVGAQ 2022
+K +Y E+ + + + E KN L EI ++ TE++A + + E E + Q
Sbjct: 1485 FKVK-NVYEESLDQLETLRRENKN-LQQEISDL-TEQIAEGGKQIHELEKIKKQ 1535
Score = 32.3 bits (72), Expect = 4.8
Identities = 27/115 (23%), Positives = 54/115 (46%), Gaps = 13/115 (11%)
Query: 1912 EPLVPRVKEVKSAQ---ETPESSLAGSPDTESPVLVN--DYEAESGNISQKSDEEDFVKV 1966
E +V +KE Q ++ SLA + + ++ N EA+ ++++++EE+ +
Sbjct: 878 EKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINA 937
Query: 1967 EDLPLKLTIYSEADLRKKMVEE--------EQKNHLSGEICEMQTEELAGNSETL 2013
E K + E KK +++ E++ H + + TEE+AG ET+
Sbjct: 938 ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETI 992
Score = 31.6 bits (70), Expect = 8.3
Identities = 86/414 (20%), Positives = 154/414 (37%), Gaps = 85/414 (20%)
Query: 1654 QDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKLMQDLDNNSITVKQRCKRKIEATGV 1713
+D LAK ++ K+ E ++ + E +L L + +Q K KI+
Sbjct: 863 KDELAKSEAKR-KELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAK 921
Query: 1714 IQSCAKEA-------------KRILEDHGSPAG-EIDD-------EDKDKDETETVKQTQ 1752
I+ + A KR LED S +IDD +K+K TE +
Sbjct: 922 IKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 981
Query: 1753 TSEVYDGPKNVRSDISDQE----------EDEESEGCPVSINLSKAETQALTNYGS--GE 1800
T E+ + + +++ +D ++E V+I L+KA+T+ G
Sbjct: 982 TEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNI-LTKAKTKLEQQVDDLEGS 1040
Query: 1801 DENEDEEMEEFEEGPVDVQTSLQANTEATEENEHDEQVLQRDF-KKTAESKNVPLEREAT 1859
E E + + E ++ L+ E+T + E+D+Q L KK E N+
Sbjct: 1041 LEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNL------- 1093
Query: 1860 SKNDQNNCPVKPCYLNILEDEQPLNSAAHKESPPTVDSTQQPNPLPLRLPEMEPLVPRVK 1919
++ +EDEQ + K+ L R+ E+ + +
Sbjct: 1094 --------------ISKIEDEQAVEIQLQKKI----------KELQARIEELGEEIEAER 1129
Query: 1920 EVKSAQETPESSLAGSPDTESPVLVNDYEAESGNIS-QKSDEEDFVKVEDLPLKLTIYSE 1978
++ E S L+ + S L A S + K E +F K+ + T+ E
Sbjct: 1130 ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHE 1189
Query: 1979 ---ADLRKKMVEE--------------EQKNHLSGEICEMQTEELAGNSETLKE 2015
A LRKK + +QK +M+T++L+ N+E + +
Sbjct: 1190 AMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISK 1243
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding domain
1 [Homo sapiens]
Length = 1412
Score = 54.3 bits (129), Expect = 1e-06
Identities = 83/421 (19%), Positives = 177/421 (42%), Gaps = 54/421 (12%)
Query: 118 GSDSQGRATA---ANNKRQLSENRKPFNFLPMQINTNKSKDASTSPPNRETIGS-----A 169
G +G A A A ++ Q ++ R+ L I +++ T R+ + A
Sbjct: 661 GEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLEEERKRMQELESLLA 720
Query: 170 QCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEK 229
Q K+ A + +++E R + A+E Q +R+ ++ + + + + E +
Sbjct: 721 QQKKALAKS----------ITQEKNRVKEALEEEQ--TRVQELEERLARQKEVLESSIAH 768
Query: 230 NERSAN---------VERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQH 280
+R A V+ L + + KE +S + + K+ +E ME+ + KK
Sbjct: 769 EKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKR-----KAKEAMEKEK--KKVQ 821
Query: 281 DLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNE 340
DL R+ +Q+E+L + ++ L +K A+A+++++ + SL S+ +LNE
Sbjct: 822 DLENRLTKQKEELELKEQKEDVL---NNKLSDALAMVEETQKTKATESLKAESLALKLNE 878
Query: 341 ELNDLIQRFHNQLRDSQPPAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKM 400
L +L + + + Q + + ++ +S++ E + + K ++
Sbjct: 879 TLAELETTKTKMIMVEERLIL-----QQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHA 933
Query: 401 RV---LQEKKQKMD----KLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGLAPV 453
+ L+EK QK+ K+ GE+ TL+D PQ + T + + + +
Sbjct: 934 QTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAKDMAYEHL 993
Query: 454 VNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQT 513
++ + + + ++ + E H S+ +LNE +K EL + V +Q
Sbjct: 994 ID-DLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELNEKQKM--ELEQNVVLVQQQ 1050
Query: 514 S 514
S
Sbjct: 1051 S 1051
Score = 49.3 bits (116), Expect = 4e-05
Identities = 162/815 (19%), Positives = 306/815 (37%), Gaps = 148/815 (18%)
Query: 131 KRQLSENRKPFNFLPMQINTNKSKDASTSPPNRETIGSAQCKELFASALSNDLLQNCQVS 190
K Q+ + K L ++ + ++ + S RE K L D +
Sbjct: 419 KTQIQDMEKEMKKLRAELRKSCTEQSVISRTLRE-------KSKVEEKLQEDSRRKLLQL 471
Query: 191 EEDGRGEPAMESS--QIVSRLVQIRDYITKAS-----SMREDLVEKNERSANVERLTHLI 243
+E G E ++ + + V +L R + KA+ R+ V + + ++T
Sbjct: 472 QEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKITQVTE-- 529
Query: 244 DHLKEQEKSYMKFLKKILARDPQQEPMEEIENLKKQ--------------HDLLKR--ML 287
D++ Q+K + + L+ Q+E E IE L+ HDL K +L
Sbjct: 530 DNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLL 589
Query: 288 QQQEQLRALQGRQAALL-ALQH------KAEQAIAVMD--------DSV-------VAET 325
Q + + G Q +L L+H + EQ + + D V T
Sbjct: 590 QHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVFT 649
Query: 326 AGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPAVPDNRRQAESLS--LTREVSQSRKP 383
AG +G S E E + R Q ++ D R ++L +T+E +++++
Sbjct: 650 AGKAAGAS-GREGEAERGEARARGEAQSQNQ----ATDGREGGKALEEYITQERNRAKET 704
Query: 384 SASERLPDEKVE-LFSKMR------VLQEKKQKMDKLLGELHTLRD--QHLNNSSSSPQR 434
ER +++E L ++ + + QEK + + L E +++ + L +
Sbjct: 705 LEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERLARQKEVLES 764
Query: 435 SVDQRSTSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLN 494
S+ A A V N LT +++ + E +K+Q L
Sbjct: 765 SIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEAMEKEKKKVQDLE 824
Query: 495 EVRKRLNELRELVHYYEQTSDMMTDA-------VNENRKDEETEESEYDSE----HENSE 543
RL + +E + EQ D++ + V E +K + TE + +S +E
Sbjct: 825 N---RLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLA 881
Query: 544 PVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINN------RSAANIRALNM 597
+ + + + + + + ++ + EI + A I +L
Sbjct: 882 ELETTKTKMIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEE 941
Query: 598 PPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHPEDAEFEQ 657
+++++ E EI + D +EE ++ V+ + SS + D +E
Sbjct: 942 KLQKVTQHHKKIEGEIATLKDNDPAPKEERPQDPLVAPMTESSAK---------DMAYEH 992
Query: 658 KINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNA 717
I+ L+AA++++ Q+++ ++ D ++ + S + D RG
Sbjct: 993 LIDDLLAAQKEILSQQEVIMKLRKD------LTEAHSRMSDL--------------RGEL 1032
Query: 718 NKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEK----IQALQTAC--- 770
N+ QK + +QQQ +EL L+E+ ++ + EK ++AL+ A
Sbjct: 1033 NEKQK-------MELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDRELKALEEALRAS 1085
Query: 771 ---PDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMR 827
LQL+ P KK TS H + S S E S D + +
Sbjct: 1086 QEKHRLQLNTEKEQK-PRKKTQTCDTSVQIEPVHTEAFSSS---QEQQSFSDLGVRCKGS 1141
Query: 828 RHEMLRE-------ELRQRRKQLE-ALMAEHQRRQ 854
RHE + + ELR R K+LE A +H+ Q
Sbjct: 1142 RHEEVIQRQKKALSELRARIKELEKARSPDHKDHQ 1176
Score = 39.3 bits (90), Expect = 0.040
Identities = 65/356 (18%), Positives = 145/356 (40%), Gaps = 55/356 (15%)
Query: 703 EEDTKQNSNNTRGNANKTQKDTGVNE--KAREKFYEAKLQQQQRELKQLQEERKKLIDIQ 760
E + ++ RG A + T E KA E++ Q++ R + L+EERK++ +++
Sbjct: 660 EGEAERGEARARGEAQSQNQATDGREGGKALEEYIT---QERNRAKETLEEERKRMQELE 716
Query: 761 EKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDN 820
+ Q + + +KS+ ++ + V
Sbjct: 717 SLLA-----------------------------------QQKKALAKSI--TQEKNRVKE 739
Query: 821 ELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQ 880
L E R + L E L ++++ LE+ +A H++R+ S + EN T Q+
Sbjct: 740 ALEEEQTRVQELEERLARQKEVLESSIA-HEKRKAKEALESE---KRKVQDLENHLTQQK 795
Query: 881 SRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVN 940
+E +A + A+++E + L + + EE E ++ N + + ++
Sbjct: 796 EISESNIAYEKRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMV 855
Query: 941 HNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQ-- 998
+ K T++ + +E L T+ + I ++ + L+ + +E+E
Sbjct: 856 EETQKTKATESLKAESLALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQESQR 915
Query: 999 --WQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQ--TLLTGPYSVMPSNVASPQ 1050
++E+I + K+Q+ QT++ ++ L + Q + G + + N +P+
Sbjct: 916 HGFEEEIMEYKEQIK---QHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPK 968
Score = 32.3 bits (72), Expect = 4.8
Identities = 38/135 (28%), Positives = 58/135 (42%), Gaps = 23/135 (17%)
Query: 1907 RLPEMEPLVPRVKEV---------KSAQETPESSLAGSPDTESPVLVNDYEAESGNIS-- 1955
R+ E+E + R KEV + A+E ES D E+ L E NI+
Sbjct: 747 RVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENH-LTQQKEISESNIAYE 805
Query: 1956 ----QKSDEEDFVKVEDLPLKLTIYSEADLRKKMVEEEQKNHLSGEICEMQ-------TE 2004
+++ E++ KV+DL +LT E K+ E+ N LS + ++ TE
Sbjct: 806 KRKAKEAMEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATE 865
Query: 2005 ELAGNSETLKEPETV 2019
L S LK ET+
Sbjct: 866 SLKAESLALKLNETL 880
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.123 0.338
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,812,018
Number of Sequences: 37866
Number of extensions: 3713594
Number of successful extensions: 32885
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 104
Number of HSP's successfully gapped in prelim test: 956
Number of HSP's that attempted gapping in prelim test: 22461
Number of HSP's gapped (non-prelim): 9386
length of query: 2024
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1907
effective length of database: 13,817,196
effective search space: 26349392772
effective search space used: 26349392772
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.