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Search of human proteins with 55741661
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55741661 hypothetical protein LOC57653 [Homo sapiens]
(1646 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55741661 hypothetical protein LOC57653 [Homo sapiens] 3271 0.0
gi|221219020 NYD-SP11 protein [Homo sapiens] 84 1e-15
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 78 8e-14
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 78 8e-14
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 77 1e-13
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 74 1e-12
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 74 1e-12
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 74 1e-12
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 74 1e-12
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 72 3e-12
gi|4506751 restin isoform a [Homo sapiens] 71 8e-12
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 70 1e-11
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 70 1e-11
gi|17975763 myelin transcription factor 1 [Homo sapiens] 70 2e-11
gi|55770834 centromere protein F [Homo sapiens] 70 2e-11
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 69 3e-11
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 69 3e-11
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 69 3e-11
gi|71061468 centromere protein E [Homo sapiens] 68 8e-11
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 67 1e-10
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 67 1e-10
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 66 2e-10
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 66 3e-10
gi|148746195 trichohyalin [Homo sapiens] 66 3e-10
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 65 4e-10
gi|38044112 restin isoform b [Homo sapiens] 65 7e-10
gi|42794779 myosin 18A isoform b [Homo sapiens] 64 9e-10
gi|28416946 myosin 18A isoform a [Homo sapiens] 64 9e-10
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 64 2e-09
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 63 3e-09
>gi|55741661 hypothetical protein LOC57653 [Homo sapiens]
Length = 1646
Score = 3271 bits (8481), Expect = 0.0
Identities = 1646/1646 (100%), Positives = 1646/1646 (100%)
Query: 1 MWHGNHVQPGATHRPNQGLEMLQGLGIGMKAFHNFNYFLFFYNVLLGLGACLSRLLISCL 60
MWHGNHVQPGATHRPNQGLEMLQGLGIGMKAFHNFNYFLFFYNVLLGLGACLSRLLISCL
Sbjct: 1 MWHGNHVQPGATHRPNQGLEMLQGLGIGMKAFHNFNYFLFFYNVLLGLGACLSRLLISCL 60
Query: 61 LGMWLIARIDRTIMQSGYEGADMGFSAWIGMLYMDHYHINPVLVSFCHILITNHREKKLQ 120
LGMWLIARIDRTIMQSGYEGADMGFSAWIGMLYMDHYHINPVLVSFCHILITNHREKKLQ
Sbjct: 61 LGMWLIARIDRTIMQSGYEGADMGFSAWIGMLYMDHYHINPVLVSFCHILITNHREKKLQ 120
Query: 121 QSTKYWCLNQSAESLRICAMRGGENRPPARVQSSSEELELRHQSLDAFPGRRLPGRGIQP 180
QSTKYWCLNQSAESLRICAMRGGENRPPARVQSSSEELELRHQSLDAFPGRRLPGRGIQP
Sbjct: 121 QSTKYWCLNQSAESLRICAMRGGENRPPARVQSSSEELELRHQSLDAFPGRRLPGRGIQP 180
Query: 181 AAKMSSVGKVTQVPNGKAYQQIFQAEVQLVHSLAATRKRAAERSVTLKSGRIPMMKKVET 240
AAKMSSVGKVTQVPNGKAYQQIFQAEVQLVHSLAATRKRAAERSVTLKSGRIPMMKKVET
Sbjct: 181 AAKMSSVGKVTQVPNGKAYQQIFQAEVQLVHSLAATRKRAAERSVTLKSGRIPMMKKVET 240
Query: 241 PEGEVMSPRQQKWMHSLPNDWIMENPVLHREKERAKREKARESENTIAAREVRGLMDTIV 300
PEGEVMSPRQQKWMHSLPNDWIMENPVLHREKERAKREKARESENTIAAREVRGLMDTIV
Sbjct: 241 PEGEVMSPRQQKWMHSLPNDWIMENPVLHREKERAKREKARESENTIAAREVRGLMDTIV 300
Query: 301 PEKISTSTFQRQAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEM 360
PEKISTSTFQRQAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEM
Sbjct: 301 PEKISTSTFQRQAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEM 360
Query: 361 NRLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSV 420
NRLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSV
Sbjct: 361 NRLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSV 420
Query: 421 LKKYAEVIEKTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSR 480
LKKYAEVIEKTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSR
Sbjct: 421 LKKYAEVIEKTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSR 480
Query: 481 HRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQRRLKHLC 540
HRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQRRLKHLC
Sbjct: 481 HRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQRRLKHLC 540
Query: 541 TICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKK 600
TICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKK
Sbjct: 541 TICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKK 600
Query: 601 QLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKY 660
QLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKY
Sbjct: 601 QLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKY 660
Query: 661 FQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETL 720
FQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETL
Sbjct: 661 FQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETL 720
Query: 721 AFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQN 780
AFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQN
Sbjct: 721 AFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQN 780
Query: 781 LAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEEN 840
LAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEEN
Sbjct: 781 LAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEEN 840
Query: 841 DQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQG 900
DQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQG
Sbjct: 841 DQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQG 900
Query: 901 EKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDMESF 960
EKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDMESF
Sbjct: 901 EKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDMESF 960
Query: 961 TISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRLILEIKKQLFSE 1020
TISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRLILEIKKQLFSE
Sbjct: 961 TISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRLILEIKKQLFSE 1020
Query: 1021 GGNFSPKEINSLCSRLEKEAARIELVESVIMLNMEKLENEYLDQANDVINKFESKFHNLS 1080
GGNFSPKEINSLCSRLEKEAARIELVESVIMLNMEKLENEYLDQANDVINKFESKFHNLS
Sbjct: 1021 GGNFSPKEINSLCSRLEKEAARIELVESVIMLNMEKLENEYLDQANDVINKFESKFHNLS 1080
Query: 1081 VDLIFIEKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTT 1140
VDLIFIEKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTT
Sbjct: 1081 VDLIFIEKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTT 1140
Query: 1141 EELLSFVQTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEA 1200
EELLSFVQTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEA
Sbjct: 1141 EELLSFVQTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEA 1200
Query: 1201 KLDVVTPESFTQLSRVGKPLIEDPAVDVIRKLLQLPNTKWPTHHCDKDPSQTGFKRHRCQ 1260
KLDVVTPESFTQLSRVGKPLIEDPAVDVIRKLLQLPNTKWPTHHCDKDPSQTGFKRHRCQ
Sbjct: 1201 KLDVVTPESFTQLSRVGKPLIEDPAVDVIRKLLQLPNTKWPTHHCDKDPSQTGFKRHRCQ 1260
Query: 1261 PENSGKKAVPSASATSAGSLQTTHPPLSHSFTPHPKPNKMERKYRVLGDKPPPAAEDFKG 1320
PENSGKKAVPSASATSAGSLQTTHPPLSHSFTPHPKPNKMERKYRVLGDKPPPAAEDFKG
Sbjct: 1261 PENSGKKAVPSASATSAGSLQTTHPPLSHSFTPHPKPNKMERKYRVLGDKPPPAAEDFKG 1320
Query: 1321 IILTLLWESSENLLTVAEEFYRKEKRPVTRPDCMCDTFDQCAENISKKILEYQSQANKYH 1380
IILTLLWESSENLLTVAEEFYRKEKRPVTRPDCMCDTFDQCAENISKKILEYQSQANKYH
Sbjct: 1321 IILTLLWESSENLLTVAEEFYRKEKRPVTRPDCMCDTFDQCAENISKKILEYQSQANKYH 1380
Query: 1381 NSCLIELRIQIRRFEELLPQVCWLVMENFKEHHWKKFFTSVKEIRGQFEEQQKRLEKRKD 1440
NSCLIELRIQIRRFEELLPQVCWLVMENFKEHHWKKFFTSVKEIRGQFEEQQKRLEKRKD
Sbjct: 1381 NSCLIELRIQIRRFEELLPQVCWLVMENFKEHHWKKFFTSVKEIRGQFEEQQKRLEKRKD 1440
Query: 1441 KNAQKLHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEKLEECTRRNGQVFITNLA 1500
KNAQKLHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEKLEECTRRNGQVFITNLA
Sbjct: 1441 KNAQKLHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEKLEECTRRNGQVFITNLA 1500
Query: 1501 TFTEKFLLQLDEVVTIDDVQVARMEPPKQKLSMLIRRKLAGLSLKEESEKPLIERGSRKW 1560
TFTEKFLLQLDEVVTIDDVQVARMEPPKQKLSMLIRRKLAGLSLKEESEKPLIERGSRKW
Sbjct: 1501 TFTEKFLLQLDEVVTIDDVQVARMEPPKQKLSMLIRRKLAGLSLKEESEKPLIERGSRKW 1560
Query: 1561 PGIKPTEVTIQNKILLQPTSSISTTKTTLGHLAAVEARDAVYLKYLASFEEELKRIQDDC 1620
PGIKPTEVTIQNKILLQPTSSISTTKTTLGHLAAVEARDAVYLKYLASFEEELKRIQDDC
Sbjct: 1561 PGIKPTEVTIQNKILLQPTSSISTTKTTLGHLAAVEARDAVYLKYLASFEEELKRIQDDC 1620
Query: 1621 TSQIKEAQRWKDSWKQSLHTIQGLYV 1646
TSQIKEAQRWKDSWKQSLHTIQGLYV
Sbjct: 1621 TSQIKEAQRWKDSWKQSLHTIQGLYV 1646
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 84.0 bits (206), Expect = 1e-15
Identities = 189/834 (22%), Positives = 340/834 (40%), Gaps = 85/834 (10%)
Query: 179 QPAAKMSSVGKVTQVPNGKAYQQIFQAEVQLVHSLAATRKRAAERSVTLKS--GRIPMMK 236
Q K+S ++ Q +++ Q ++ S + ++ E VTL+ R K
Sbjct: 1498 QAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEK 1557
Query: 237 KVETPEGEVMSPRQQKWMHSLPNDWIMENPVLHREKERAKREKARESENTIAAREVRGLM 296
+ + E + + KW E E++ A+ E+ E A+E R L
Sbjct: 1558 EQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLA 1617
Query: 297 DTIVPEKISTSTFQR-QAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGLFLK--KL 353
V KI+ + QAE K E LA E+++Q E E L L K K+
Sbjct: 1618 QAYV--KITQDDREMAQAEGKFAQKEETLAQRGEKLSQ---EAEKLAQKRKKLAKKWEKV 1672
Query: 354 TESDEEMNRLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSR 413
+E++ + K+ N+ ++ L + + + QE++EL+ + L +
Sbjct: 1673 AREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKE 1732
Query: 414 TD------KLKSVLKKYAEVIEKTSYL---MRPEVYRLINEEAMVMNYALLGNRKALAQL 464
+ KL KK AE E ++ + E +L EE + L+ ++ LAQ
Sbjct: 1733 EELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEEL-----LIQEKEKLAQH 1787
Query: 465 FVNLMESTLQQELDSRHRWQGLVDTWK-ALKKEALLQSFSEFMASESI-HTPPAVTKELE 522
+ E ++E R R Q + K A K+E + S E ++ I + + +E +
Sbjct: 1788 KEKMPE---EEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKK 1844
Query: 523 VMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRL 582
+ + + L QR+ L L ++SK QL + + L NK L
Sbjct: 1845 NLAQEKEKLAQRKENLLYNKERL---THSKKQLVQVKNKLGMFNKILAQVEEKLTQEKET 1901
Query: 583 LYEKT-----WQECLMHVQN--CKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVE-- 633
+ +K ++ L+ V++ KKQ + +E+ + + + Q L+G+++
Sbjct: 1902 VIKKKEKLAETEKKLVQVEDSLAKKQ----EKLAQEKMKLALEKAMVQGKKRLRGELDIA 1957
Query: 634 EDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKH 693
++ + L+ + LA++ + + L + E Q + E +K
Sbjct: 1958 KEEKALNLEMKRLAEEK-------MRLVEGKETLSKGETPETSRQRKMTQVEQELFERKL 2010
Query: 694 SLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKE--VME 751
SLE ++ H DR+L + K L F + + +++ + + L+ K + +
Sbjct: 2011 SLEEKIL-LHEDRILAMEESEIAKGKLEFTRGQ-RIFVQGQRKLAKASRKLIKKRESLSK 2068
Query: 752 YPAIMLKELNSYS----------------SALSQYFFVRE---IFEQNLAGEVIFKFRQP 792
PA + K L + + + + FV+E EQ+ + F +
Sbjct: 2069 EPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEK 2128
Query: 793 EAH-EKPSQKRVKKLRKKQGSKEDMTRSEESISSGTST-ARSVEEV----EEENDQEMES 846
+ K +K +K RK M EE ++ S AR EV EEE E E
Sbjct: 2129 RSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEE 2188
Query: 847 FITEEVLGQQKKSPLHAKM-DESKEGSIQGLEEMQVEREGSLN-PSLNEENVKGQGEKKE 904
I L ++ + AK D+ KE ++E++ E S SL +E K + E
Sbjct: 2189 VIP--FLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSE 2246
Query: 905 ESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDME 958
E EE +E+EE EEEE EEE+E KE +E +E EEE+K++ +E E+++
Sbjct: 2247 EEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQ 2300
Score = 72.0 bits (175), Expect = 4e-12
Identities = 175/792 (22%), Positives = 320/792 (40%), Gaps = 103/792 (13%)
Query: 200 QQIFQAEVQLVHSLAATRKRAAERSVTLKSGRIPMMKKVETPEGEVMSPRQQKWMHS--- 256
+Q+ Q E +L A + +R + G+ ++ GE +S +K
Sbjct: 1607 RQLAQEERKLAQ--AYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKK 1664
Query: 257 LPNDWIMENPVLHREKERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHK 316
L W E EK K K E +N I A++V L P++ ++ + +
Sbjct: 1665 LAKKW--EKVAREEEKLAKKGGKLAEVKN-ILAQKVEEL-----PQR------EQNLDWQ 1710
Query: 317 RKSYESALASFQEEIAQVGKEMEPLIVDTGGLF--LKKLTESDEEMNRLFLKVENDTNLE 374
K L + ++ ++ + E L + G L KKL E +E + K+ +
Sbjct: 1711 EKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKL 1770
Query: 375 DYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYL 434
+ L++ +K+A K+++ E +E L +K ++IEK L
Sbjct: 1771 AQEEELLIQEKEKLAQH----KEKMPEEEERLG--------------RKREQLIEKKMKL 1812
Query: 435 MRPEVYRLINEEAMVMNYALLGNRKALAQLFVNLM---ESTLQQELDSRHRWQGLVDTWK 491
+ + + E + N +L +K LAQ NL E Q++ + + + L + K
Sbjct: 1813 AQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKK 1872
Query: 492 ALKK-EALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSY 550
L + + L F++ +A +T+E E ++K + L + K L + D L
Sbjct: 1873 QLVQVKNKLGMFNKILAQ----VEEKLTQEKETVIKKKEKLAETE-KKLVQVEDSLAKKQ 1927
Query: 551 SKTQLTEWHSSLNS--------LNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQL 602
K + +L L ELD + + + + K E M + K+ L
Sbjct: 1928 EKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEM---KRLAEEKMRLVEGKETL 1984
Query: 603 LDWKA--FTEEEAETLVNQFFFQMVGALQGKV--EEDLELLDKSFETLADQTEWQSSHLF 658
+ + + T V Q F+ +L+ K+ ED L + E + E
Sbjct: 1985 SKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLE------- 2037
Query: 659 KYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEA--HLDRLLDQLRQQSD 716
F +++ Q +L +L K+ E ++ + +++ +A L R +L Q+
Sbjct: 2038 --FTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEI 2095
Query: 717 KETLAFHLEKVKDYLKNMKSR--------YECFHTLLTKEVMEYPAIMLKELNSYSSALS 768
K T VK+ +++ + + LTK+ + K N ++
Sbjct: 2096 KMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMIN 2155
Query: 769 QYFFVREIFEQNLA---GEVIFKFRQPEAHEK----PSQKRVKKLRK--KQGSKEDMTRS 819
+ + E E LA EVI + E+ P KR + RK K+G K
Sbjct: 2156 KEEKMTEE-ESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKP----- 2209
Query: 820 EESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEM 879
+E SS S E EE + ++ +E L +++ + + +E + EE
Sbjct: 2210 KEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEER 2269
Query: 880 QVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSV 939
+ E EG E+ V+ + E+K++ ++E +KEE +E+E++ EEKEE ++EE ESLS
Sbjct: 2270 KEEEEGE------EKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSD 2323
Query: 940 GEEEDKEEGLEE 951
EEE++ LEE
Sbjct: 2324 EEEEEESCSLEE 2335
Score = 47.0 bits (110), Expect = 2e-04
Identities = 172/897 (19%), Positives = 359/897 (40%), Gaps = 93/897 (10%)
Query: 351 KKLTESDEEMNRLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRK---QEIKELDEALH 407
K+L + +E++++ K+ + + + E W +V +L K Q+ K+ +E
Sbjct: 1487 KRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTL 1546
Query: 408 SLEFSRT--DKLKSVLKKYAEVIEKTSYLM------RPEVYRLINEEAMVMNYALLGNR- 458
E SR +K + V ++ + E+ + R E R E + L
Sbjct: 1547 EEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEE 1606
Query: 459 KALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASES---IHTPP 515
+ LAQ L ++ ++ D R Q K +KE L E ++ E+
Sbjct: 1607 RQLAQEERKLAQAYVKITQDDREMAQA---EGKFAQKEETLAQRGEKLSQEAEKLAQKRK 1663
Query: 516 AVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVD 575
+ K+ E + + + L ++ K L + ++L +L + +L+ KEL ++
Sbjct: 1664 KLAKKWEKVAREEEKLAKKGGK-LAEVKNILAQKVE--ELPQREQNLDWQEKEL-AQELE 1719
Query: 576 CMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEED 635
+ W + E +W+E ++ + K L++ K EE E L Q + + + K+ ++
Sbjct: 1720 ELEWD--MEELSWKEEELNQEEGK--LVEEKKKLAEEEEALAWQR--EKLSEEETKLAQE 1773
Query: 636 LELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSL 695
ELL + E LA E + ++ QL E +E + E + K L
Sbjct: 1774 EELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMIL 1833
Query: 696 ESQVQEAHLDRLLDQLRQQ--SDKETLAFHLEKV---KDYLKNMKSRYECFHTLLTK--- 747
+ A + L Q +++ KE L ++ E++ K L +K++ F+ +L +
Sbjct: 1834 YQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEE 1893
Query: 748 EVMEYPAIMLKELNSYSSALSQYFFVREIF---EQNLAGE----------VIFKFRQPEA 794
++ + ++K+ + + V + ++ LA E V K R
Sbjct: 1894 KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGE 1953
Query: 795 HEKPSQKRVKKLRKKQGSKEDM--TRSEESISSG----TSTARSVEEVEEENDQEMESFI 848
+ +++ L K+ ++E M +E++S G TS R + +VE+E +
Sbjct: 1954 LDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQE--------L 2005
Query: 849 TEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEEN-VKGQGEKKEESE 907
E L ++K LH E I +EE ++ + G L + + V+GQ + + S
Sbjct: 2006 FERKLSLEEKILLH-------EDRILAMEESEIAK-GKLEFTRGQRIFVQGQRKLAKASR 2057
Query: 908 EEDEKEEEEEEEKLEEEKEEKEAQE-EQESLSVGEEEDKEEGLEEIYYEDMESFTISSGN 966
+ +K E +E + K K Q+ ++ + +EE K ++ + +I
Sbjct: 2058 KLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSK 2117
Query: 967 TYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRLILEIKKQLFSEGGNFSP 1026
+ ++E + S + ++ A+ ++ R ++ ++++ E +
Sbjct: 2118 -----LDIKEWDFSEKRSELTK---DEKKLARKQRKLANKMRRMINKEEKMTEEESKLAR 2169
Query: 1027 KEINSLCSRLEKEAARIELVESVIMLNMEKLENEYLDQANDVINKFESKFHNLSVDLIFI 1086
K + ++E IE E + L + + + + KF S+ + + F
Sbjct: 2170 KHSEVILD--DEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFS 2227
Query: 1087 EKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTTEELLSF 1146
E+++ LL L+ Q + S+ + ++ + +++ +E R E EE
Sbjct: 2228 EEMESLLDELEK----QESLSSEEEEEREEEEEREEEEVREEEEERKE------EEEGEE 2277
Query: 1147 VQTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEAKLD 1203
Q KE+ ++ + + V E VF EE+++ L+ E EE L+
Sbjct: 2278 KQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLE 2334
Score = 45.1 bits (105), Expect = 6e-04
Identities = 173/853 (20%), Positives = 331/853 (38%), Gaps = 134/853 (15%)
Query: 807 RKKQGSKEDMTRSEESISS-GTSTARSVEEVEEENDQEMESFITEEVLGQQKK-SPLHAK 864
R+ ++ + EE+++ G ++ E++ ++ + + + E+V +++K + K
Sbjct: 1628 REMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKW--EKVAREEEKLAKKGGK 1685
Query: 865 MDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKE-ESEEEDEKEEE--EEEEKL 921
+ E K Q +EE+ +RE +L+ E+ + + E+ E + EE KEEE +EE KL
Sbjct: 1686 LAEVKNILAQKVEELP-QREQNLD--WQEKELAQELEELEWDMEELSWKEEELNQEEGKL 1742
Query: 922 EEEKEEKEAQEEQESLS-----VGEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEE 976
EEK K+ EE+E+L+ + EEE K EE+ ++ E +P EE
Sbjct: 1743 VEEK--KKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEK-----MPEEE 1795
Query: 977 EHCRKSHSTF----------SAMFINDTSSAKFIEQVTIPSRLILEIKKQLFSEGGNFSP 1026
E + +IN + + + + + KK L E +
Sbjct: 1796 ERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQ 1855
Query: 1027 KEINSLCSRLEKEAARIELVESVIMLNM-EKL---ENEYLDQANDVINKFESKFHNLSVD 1082
++ N L ++ ++ +LV+ L M K+ E L Q + + K + K
Sbjct: 1856 RKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKK 1915
Query: 1083 LIFIE----KIQRLLTNLQVKIKCQVAKSN------------SQTNGLNFSLQQLQ---- 1122
L+ +E K Q L ++K+ + A + LN +++L
Sbjct: 1916 LVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKM 1975
Query: 1123 ---------NKIKTCQESRGEKTTVTTEELLSFVQTWKEK-LSQRIQYLNCSLDRVSMTE 1172
+K +T + SR K T +EL + +EK L + L ++ +
Sbjct: 1976 RLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGK 2035
Query: 1173 LVFT---NTILKDQEE----DSDILTSSEALEEE-AKLDVVTPESFTQLSRVGKPLI-ED 1223
L FT ++ Q + ++ E+L +E AKL+ + ++ +L+R + L E+
Sbjct: 2036 LEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKIL-KALQKLTRDERKLTQEE 2094
Query: 1224 PAVDVIRKLLQLPNTKWPTHHCDKDPSQTGFKRHRCQPENSGKKAVPSASATSAGSLQTT 1283
+ +++ L + + D + F R + KK L
Sbjct: 2095 IKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKK------------LARK 2142
Query: 1284 HPPLSHSFTPHPKPNKMERKYRVLGDKPPPAAEDFKGIILTLLWE---SSENLLTVAEEF 1340
L++ K +M K + ++ A +IL E E ++ +
Sbjct: 2143 QRKLAN------KMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRR 2196
Query: 1341 YRKEKRPVTRPDCMCDTFDQCAENISKKILEYQSQANKYHNSCLIELRIQIRRFEELLPQ 1400
+RK K D+ E S ++ E +S+ H S +E + +E L
Sbjct: 2197 WRKRKE--------AKRGDKPKEKFSSQVDEVESEE---HFSEEMESLLDELEKQESLSS 2245
Query: 1401 VCWLVMENFKEHHWKKFFTSVKEIRGQFEEQQKRLEKRKDKNAQKLHLNLGHPVH----- 1455
E +E ++ +E + + E ++K++EK +++ +K V
Sbjct: 2246 EEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEV 2305
Query: 1456 FQEMESLHLSEEERQEELDSMIRMNKEKLEECTRRNGQVFIT----NLATFTEKFLLQLD 1511
F+E E + +SEEE + D LEE R ++ L K L +
Sbjct: 2306 FEEKEEI-MSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRE 2364
Query: 1512 EVVTI---------DDVQVARMEPPKQKLSMLIRRKLAGLSLKEESEKPLIERGSRKWPG 1562
V++I +++ ++ P +KL L +KE++ P+ E+ W
Sbjct: 2365 RVLSILRGVPHGKGRAIRLGVLKSPLKKLMS------TALEMKEKTPVPVPEK-QISWED 2417
Query: 1563 IKPTEVTIQNKIL 1575
K T V I K L
Sbjct: 2418 KKATVVEIPRKFL 2430
Score = 39.7 bits (91), Expect = 0.024
Identities = 42/171 (24%), Positives = 74/171 (43%), Gaps = 25/171 (14%)
Query: 797 KPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQ 856
K +K V+K RK K +MT+ E +S ++EE + + ++
Sbjct: 1401 KQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDW 1460
Query: 857 KKS-----PLHAKMDESKEGSIQGLEEMQVEREGSLNPS---LNEENVKGQGEKK----- 903
KK+ +H + +S + + E+ ++ E L+ + L+ E Q +KK
Sbjct: 1461 KKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEE 1520
Query: 904 ----------EESEEEDEKEEEEE--EEKLEEEKEEKEAQEEQESLSVGEE 942
+S+E+ K+EEE EE++ E EEKE Q +E + EE
Sbjct: 1521 WKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEE 1571
Score = 38.5 bits (88), Expect = 0.054
Identities = 124/686 (18%), Positives = 276/686 (40%), Gaps = 110/686 (16%)
Query: 207 VQLVHSLAATRKRAAERSVTLKSGRIPMMKKVETPEGEVMSPRQQKWMHSLPNDWIMENP 266
+Q LA +++ E L R +++K ++ ++++W++S+ +
Sbjct: 1778 IQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMK-----LAQKRERWINSM-EELTKNKM 1831
Query: 267 VLHREKERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQR-QAEHKRKSYESALA 325
+L+++K A+ +K E A+ L+ E+++ S Q Q ++K + LA
Sbjct: 1832 ILYQKKNLAQEKKNLAQEKEKLAQRKENLLYN--KERLTHSKKQLVQVKNKLGMFNKILA 1889
Query: 326 SFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQALLELW 385
+E++ Q E E +I +KL E+++++ +ED +L +
Sbjct: 1890 QVEEKLTQ---EKETVIKKK-----EKLAETEKKL----------VQVED----SLAKKQ 1927
Query: 386 DKVAG---RLLLRKQEIKELDEALHSLEFSRTDK-LKSVLKKYAE----VIEKTSYLMRP 437
+K+A +L L K ++ L+ ++ +K L +K+ AE ++E L +
Sbjct: 1928 EKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKG 1987
Query: 438 EVYRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEA 497
E + M L RK ++L E L E D A+++
Sbjct: 1988 ETPETSRQRKMTQVEQELFERK------LSLEEKILLHE-----------DRILAMEESE 2030
Query: 498 LLQSFSEFMASESIHTPPA--VTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQL 555
+ + EF + I + K ++K + L + K + L + + +L
Sbjct: 2031 IAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKL 2090
Query: 556 TEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAET 615
T+ + + + L +E + ++ K + +W F+E+ +E
Sbjct: 2091 TQEEIKMTKMKRALFV-----------------KERRLSIEQSKLDIKEWD-FSEKRSEL 2132
Query: 616 LVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSEL 675
++ + + Q K+ + + E + ++ S L + EV+ + E
Sbjct: 2133 TKDE---KKLARKQRKLANKMRRMINKEEKMTEE----ESKLARKHSEVIL---DDEEEG 2182
Query: 676 LVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMK 735
++E E+ +++ +K E++ + ++ Q+ + +E + +E + D L+ +
Sbjct: 2183 GIEEEEVIPFLKRRWRKRK-EAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQE 2241
Query: 736 SRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAH 795
S L ++E E +E VRE E+ E + + +
Sbjct: 2242 S-------LSSEEEEEREEEEEREEEE----------VREEEEERKEEEEGEEKQVEKEE 2284
Query: 796 EKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFI--TEEVL 853
E+ +K+ +K +++ KE++ +E I S T +E EEE +E + +E+L
Sbjct: 2285 EEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEIL 2344
Query: 854 GQQKKSPLHAKMDESKEGSIQGLEEM 879
++K+ K+ E + S++G E +
Sbjct: 2345 KKEKQ----FKLQEQRRKSLRGRERV 2366
Score = 38.1 bits (87), Expect = 0.071
Identities = 36/121 (29%), Positives = 59/121 (48%), Gaps = 14/121 (11%)
Query: 842 QEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQV-EREGSLNPSLNEENVKGQG 900
++M +T+EV+ ++ P + + K + GLEE QV ++G L NV
Sbjct: 1326 EDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGK 1385
Query: 901 E--KKEESE----------EEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEE-DKEE 947
E KKEE + + +KE + + K E KEE++ EE E ++ EE+ K+E
Sbjct: 1386 EISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQE 1445
Query: 948 G 948
G
Sbjct: 1446 G 1446
Score = 35.0 bits (79), Expect = 0.60
Identities = 31/138 (22%), Positives = 65/138 (47%), Gaps = 8/138 (5%)
Query: 805 KLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESF--ITEEVLGQQKKSPLH 862
K K++ K + E+ +G + E ++E+ + E + + E +L + K +
Sbjct: 1479 KAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQY 1538
Query: 863 AKMDE---SKEGSIQGLEEMQ--VEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEE 917
+E +E S +G E+ Q E + + + + + E+ ++E++ +E
Sbjct: 1539 KDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQE 1598
Query: 918 EEKLEEEKEEKEAQEEQE 935
EEKL +E E + AQEE++
Sbjct: 1599 EEKLAQE-ERQLAQEERK 1615
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 77.8 bits (190), Expect = 8e-14
Identities = 129/631 (20%), Positives = 276/631 (43%), Gaps = 87/631 (13%)
Query: 366 KVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKY- 424
K+ N TN E T D+ ++ +EL+ +H++ K + + Y
Sbjct: 89 KINNGTNPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYY 148
Query: 425 -AEVIEKTSYLMRPEVYRLIN--EEAMVMNYAL--LGNRKALAQLFVNLMESTLQQELDS 479
+++ R + RL + + A + AL + +K A ++ E T +++ S
Sbjct: 149 SQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIE--ELTKERDALS 206
Query: 480 RHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKT-QNVLQQRRLKH 538
++ + + +K A LQ + + SE E+++ +K + L++ +L
Sbjct: 207 LELYRNTITDEELKEKNAKLQEKLQLVESEK--------SEIQLNVKELKRKLERAKL-- 256
Query: 539 LCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLY---EKTWQECLMHV 595
LLP + + L S++ +L + +W RL EK W++
Sbjct: 257 ------LLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ----- 305
Query: 596 QNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTE--WQ 653
++++ +W+ +E+ E + Q + + + K+ E++ + E + Q E W+
Sbjct: 306 ---EEKIQEWEEKIQEQEEKIREQE--EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360
Query: 654 SSHLFKYFQEVVQLWEAH-----QSELLVQELELEKRMEQ--HRQKHSLESQVQEAHLDR 706
+ +E+ +WE Q E++ ++ E + +E+ H Q+ E + + ++
Sbjct: 361 KEEKMRRQEEM--MWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 418
Query: 707 LLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSA 766
+ +Q ++Q + + EK+++ + ++ + + + +E + ++E
Sbjct: 419 IREQEKRQEQEAKMWRQEEKIREQEEKIREQEK---KMWRQEEKIHEQEKIREEEKRQEQ 475
Query: 767 LSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSG 826
+ +I EQ E I++ ++ + HE+ +K+RK++ E + R EE I
Sbjct: 476 EEMWRQEEKIHEQ----EEIWRQKE-KMHEQE-----EKIRKQE---EKVWRQEEKIREQ 522
Query: 827 TSTARSVEEV----EEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVE 882
R EE EE+ ++ E + EE + +Q+K K E ++ + E+++ +
Sbjct: 523 EEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQ 582
Query: 883 REGSLNPSLNEENVKGQGEKKEESEEEDEKEEE---EEEEKLEEE-----------KEEK 928
E EE ++ Q EK++E EE+ K+EE E+EEK++E+ +E++
Sbjct: 583 EEKVWR---QEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQE 639
Query: 929 EAQEEQESLSVGEEEDKEEGLEEIYYEDMES 959
E +EQE +GE+E+K EE E E+
Sbjct: 640 EMTQEQEE-KMGEQEEKMCEQEEKMQEQEET 669
Score = 62.4 bits (150), Expect = 4e-09
Identities = 79/351 (22%), Positives = 159/351 (45%), Gaps = 61/351 (17%)
Query: 629 QGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLW----EAHQSELLVQELELEK 684
Q K +E + + E + +Q E K ++ ++W + H+ E + +E + ++
Sbjct: 422 QEKRQEQEAKMWRQEEKIREQEE-------KIREQEKKMWRQEEKIHEQEKIREEEKRQE 474
Query: 685 RMEQHRQKHSLESQV----QEAHLDRLLDQLRQQSDK-----ETLAFHLEKVKDYLKNMK 735
+ E RQ+ + Q Q+ + +++R+Q +K E + EK+++ + M
Sbjct: 475 QEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMW 534
Query: 736 SRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAH 795
+ E ++ E + +E + +I+E+ E K + E
Sbjct: 535 RQEE--------KIREQEEMWREEEKMHEQ--------EKIWEEEKRQEQEDKMWRQEEK 578
Query: 796 EKPSQKRV----KKLR----KKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESF 847
+ +++V +K+R K+Q +E M + EE I ++E EE+ ++ E
Sbjct: 579 IREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIRE---QEEKIQEQEEKIREQEEKI 635
Query: 848 ITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESE 907
+E + Q+++ KM E +E + E+MQ + E EE ++ Q +K E E
Sbjct: 636 REQEEMTQEQEE----KMGEQEEKMCEQEEKMQEQEETMWR---QEEKIREQEKKIREQE 688
Query: 908 EEDEKEEE---EEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYE 955
E+ ++EE E+EEK+ E++E+ QEE+ + E+E+K EE +E
Sbjct: 689 EKIREQEEMMQEQEEKMWEQEEKMCEQEEK----MQEQEEKMRRQEEKMWE 735
Score = 58.9 bits (141), Expect = 4e-08
Identities = 124/570 (21%), Positives = 240/570 (42%), Gaps = 66/570 (11%)
Query: 403 DEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRP--EVYRLINEEAMVMNYALLGNRKA 460
DE L +KL+ V + +E+ L R L+ ++ + LG K
Sbjct: 216 DEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG--KE 273
Query: 461 LAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMAS--ESIHTPPAVT 518
L + L + EL +R Q W+ +E +Q + E + E I
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWR---QEEKIQEWEEKIQEQEEKIREQEEKI 330
Query: 519 KELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTE---WHSSLNSLNKELDTYHVD 575
+E E ++ Q + + + + +++ K + E W KE +
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE-------KEEKMRRQE 383
Query: 576 CMMW-----IRLLYEKTWQECLMHVQNCKKQ----LLDWKAFTEEEAETLVNQFFFQMVG 626
MMW IR L EK ++ + Q K+Q + + + E+EA+ + + +
Sbjct: 384 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE---EKIR 440
Query: 627 ALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRM 686
+ K+ E + + + E + +Q + + + QE ++W Q E + ++ E+ ++
Sbjct: 441 EQEEKIREQEKKMWRQEEKIHEQEKIREE---EKRQEQEEMWR--QEEKIHEQEEIWRQK 495
Query: 687 EQ-HRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLL 745
E+ H Q+ + Q E + R +++R+Q +K + EK+ + ++ + E +
Sbjct: 496 EKMHEQEEKIRKQ--EEKVWRQEEKIREQEEK--IREQEEKMWRQEEKIREQEEMWRE-- 549
Query: 746 TKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKK 805
+E M + +E + +I EQ E ++ RQ E + +KR ++
Sbjct: 550 -EEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQE---EKVW--RQEEKIREQEEKRQEQ 603
Query: 806 LRKKQGSKEDMTRSEESISSGTSTARSVEEV---EEENDQEMESFITEEVLGQQKKSPLH 862
K +E + EE I R EE +EE QE E + E+ ++K
Sbjct: 604 EEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQ---EEKMCEQE 660
Query: 863 AKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEE----EEE 918
KM E +E ++ EE E+E + EE ++ Q E +E EE+ E+E E+E
Sbjct: 661 EKMQEQEE-TMWRQEEKIREQEKKIREQ--EEKIREQEEMMQEQEEK-MWEQEEKMCEQE 716
Query: 919 EKLEEEKEEKEAQEE---QESLSVGEEEDK 945
EK++E++E+ QEE ++ + + ++E+K
Sbjct: 717 EKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746
Score = 33.5 bits (75), Expect = 1.7
Identities = 77/402 (19%), Positives = 159/402 (39%), Gaps = 53/402 (13%)
Query: 1091 RLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTW 1150
R+LT + +++ + S L + L +++ + GE E+ LS V T
Sbjct: 133 RILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGE-----LEQALSAVATQ 187
Query: 1151 KEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQ--EEDSDILTSSEALE-EEAKLDVVTP 1207
K+K + I+ L D +S+ ++ NTI ++ E+++ + + +E E++++ +
Sbjct: 188 KKKADRYIEELTKERDALSLE--LYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVK 245
Query: 1208 ESFTQLSRVGKPLIEDPA---VDVIRKLLQLPNTKWPTHHCDKDPSQTGFKRHRCQPENS 1264
E +L R L + D + K LQ + K + + + R Q E
Sbjct: 246 ELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENEL----WNRLNQQQEEK 301
Query: 1265 GKKAVPSASATSAGSLQTTHPPLSHSFTPHPKPNKMERKYRVLGDKPPPAAEDFKGIILT 1324
+ + + KM R+ ++ +K +
Sbjct: 302 MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE----- 356
Query: 1325 LLWESSENLLTVAEEFYRKEKRPVTRPDCMCDTFDQCAENISKKILEYQSQANKYHNSCL 1384
++WE E + E + KE++ + + M + +KI E + K H
Sbjct: 357 MMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK--------EEKIRELE---EKMHEQEK 405
Query: 1385 IELRIQIRRFEELLPQVCWLVMENFKEHHWKKFFTSVKEIRGQFEEQQKRLEKRKDKNAQ 1444
I + + R+ EE + + + ++ K + ++IR Q EE+ + EK+ + +
Sbjct: 406 IREQEEKRQEEEKIRE------QEKRQEQEAKMWRQEEKIREQ-EEKIREQEKKMWRQEE 458
Query: 1445 KLHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEKLEE 1486
K+H E + EEE+++E + M R +EK+ E
Sbjct: 459 KIH------------EQEKIREEEKRQEQEEMWR-QEEKIHE 487
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 77.8 bits (190), Expect = 8e-14
Identities = 130/616 (21%), Positives = 259/616 (42%), Gaps = 85/616 (13%)
Query: 366 KVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKY- 424
K+ N TN E T D+ ++ +EL+ +H++ K + + Y
Sbjct: 89 KINNGTNPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYY 148
Query: 425 -AEVIEKTSYLMRPEVYRLIN--EEAMVMNYAL--LGNRKALAQLFVNLMESTLQQELDS 479
+++ R + RL + + A + AL + +K A ++ E T +++ S
Sbjct: 149 SQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIE--ELTKERDALS 206
Query: 480 RHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKT-QNVLQQRRLKH 538
++ + + +K A LQ + + SE E+++ +K + L++ +L
Sbjct: 207 LELYRNTITDEELKEKNAKLQEKLQLVESEK--------SEIQLNVKELKRKLERAKL-- 256
Query: 539 LCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLY---EKTWQECLMHV 595
LLP + + L S++ +L + +W RL EK W++
Sbjct: 257 ------LLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ----- 305
Query: 596 QNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTE--WQ 653
++++ +W+ +E+ E + Q + + + K+ E++ + E + Q E W+
Sbjct: 306 ---EEKIQEWEEKIQEQEEKIREQE--EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360
Query: 654 SSHLFKYFQEVV--------QLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLD 705
+ +E++ +L E + ++E E EKR E+ + + + Q QEA +
Sbjct: 361 KEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQE-EKRQEEEKIREQEKRQEQEAKMW 419
Query: 706 RLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSS 765
R +++R+Q EK+++ K M + E H E I +E
Sbjct: 420 RQEEKIREQE---------EKIREQEKKMWRQEEKIH--------EQEKIREEEKRQEQE 462
Query: 766 ALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISS 825
+ + +I EQ K + E K +K ++ K +E + EE +
Sbjct: 463 EMWRQ--EEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWR 520
Query: 826 GTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREG 885
R EE E ++++ EE++ +Q++ KM E +E +Q E+M+ + E
Sbjct: 521 QEEKIREQEEKIREQEEKIRE--QEEMMQEQEE-----KMGEQEE-KMQEQEKMRRQEEK 572
Query: 886 SLNPSLNEENVKGQGEKKEESEE---EDEKEEEEEEEKLEEEKEEKEAQEE---QESLSV 939
EE ++ Q EK E EE E E++ E+EE ++E++E+ QEE ++ +
Sbjct: 573 IRE---QEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 629
Query: 940 GEEEDKEEGLEEIYYE 955
E+E+K EE +E
Sbjct: 630 QEQEEKMRRQEEKMWE 645
Score = 47.4 bits (111), Expect = 1e-04
Identities = 101/538 (18%), Positives = 212/538 (39%), Gaps = 60/538 (11%)
Query: 675 LLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNM 734
L Q+ EL+ M + +H+++ EA D + + D A LE+ +
Sbjct: 135 LTCQKTELQ--MALYYSQHAVKQLEGEAR-----DLISRLHDSWKFAGELEQALSAVATQ 187
Query: 735 KSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEA 794
K + + + LTKE L Y + ++ E+ E+N ++ K + E+
Sbjct: 188 KKKADRYIEELTKERDAL------SLELYRNTITD----EELKEKN--AKLQEKLQLVES 235
Query: 795 HEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLG 854
+ Q VK+L++K + + ++ + + ++ V + ++E L
Sbjct: 236 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLN 295
Query: 855 QQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEE 914
QQ++ + + ++ +E EE ++ Q EK E EE+ +E+
Sbjct: 296 QQQEEKMWRQEEKIQEW---------------------EEKIQEQEEKIREQEEKI-REQ 333
Query: 915 EEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPL 974
EE+ + EE EKE + ++ + E+E+K LEE+ +E E +
Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIR 393
Query: 975 EEEHCRKSHSTFSAMFINDTSSAKF---IEQVTIPSRLILEIKKQLFSEGGNFSPKE-IN 1030
E+E R+ AK E++ I E +K+++ + +E I
Sbjct: 394 EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR 453
Query: 1031 SLCSRLEKE-----AARIELVESVIMLNMEKLENEYLDQANDVINKFESKFHNLSVDLIF 1085
R E+E +I E + + E E + + + + + E K H+
Sbjct: 454 EEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEK--- 510
Query: 1086 IEKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTTEELLS 1145
I + + + + KI+ Q K Q + + +Q + +E GE+ E+
Sbjct: 511 IREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQ----EEKMGEQEEKMQEQ--E 564
Query: 1146 FVQTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEAL-EEEAKL 1202
++ +EK+ ++ + + +++ E K +E++ + E + E+E K+
Sbjct: 565 KMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKM 622
Score = 36.6 bits (83), Expect = 0.21
Identities = 89/528 (16%), Positives = 217/528 (41%), Gaps = 71/528 (13%)
Query: 203 FQAEVQLVHSLAATRKRAAERSVTLKSGRIPMMKKVETPEGEVMSPRQQKWMHSLPNDWI 262
F E++ S AT+K+ A+R + + T E + +S + + +++ ++ +
Sbjct: 173 FAGELEQALSAVATQKKKADRYI-----------EELTKERDALS--LELYRNTITDEEL 219
Query: 263 MENPVLHREKERAKREKARESENTIAAREVRGLMDT---IVPEKISTSTFQRQAEHKRKS 319
E + +E+ + ++ +SE + +E++ ++ ++P++ Q +A+H K
Sbjct: 220 KEKNA--KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQ----QLQAEADHLGKE 273
Query: 320 YESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQ 379
+S A Q ++ E +E NRL + E ++ IQ
Sbjct: 274 LQSVSAKLQAQV-----------------------EENELWNRLNQQQEEKMWRQEEKIQ 310
Query: 380 ALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRPEV 439
E + ++ ++++I+E +E + E +K + + ++ + EK + R E
Sbjct: 311 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEE 370
Query: 440 YRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKK---- 495
EE + + ++ + + E +E + R + + W+ +K
Sbjct: 371 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM--WRQEEKIREQ 428
Query: 496 --EALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKT 553
+ Q + E IH + +E + + + Q+ +++ I + +
Sbjct: 429 EEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQE 488
Query: 554 QLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEA 613
++ + + +++ D IR EK W++ ++ ++++ + + E+
Sbjct: 489 KIRKQEEKVWRQEEKMH----DQEEKIREQEEKMWRQ-EEKIREQEEKIREQEEKIREQE 543
Query: 614 ETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWE---- 669
E + Q + +G + K++E E + + E + +Q E K ++ ++WE
Sbjct: 544 EMMQEQ--EEKMGEQEEKMQEQ-EKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEK 600
Query: 670 AHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDK 717
+ E ++QE E EK EQ + E ++QE +++R+Q +K
Sbjct: 601 IREQEEMMQEQE-EKMWEQEEKMCEQEEKMQEQE-----EKMRRQEEK 642
Score = 31.2 bits (69), Expect = 8.7
Identities = 36/161 (22%), Positives = 65/161 (40%), Gaps = 35/161 (21%)
Query: 1326 LWESSENLLTVAEEFYRKEKRPVTRPDCMCDTFDQCAENISKKILEYQSQANKYHNSCLI 1385
+W E + E + +KEK E I K+ + Q K H+
Sbjct: 464 MWRQEEKIREQEEIWRQKEKMHEQ-------------EKIRKQEEKVWRQEEKMHDQ--- 507
Query: 1386 ELRIQIRRFEELLPQVCWLVMENFKEHHWKKFFTSVKEIRGQFEEQQKRLEKRKDKNAQK 1445
+IR EE + W E +E K ++E + EQ++ ++++++K ++
Sbjct: 508 --EEKIREQEEKM----WRQEEKIREQEEK-----IREQEEKIREQEEMMQEQEEKMGEQ 556
Query: 1446 LHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEKLEE 1486
QE E + EE+ +E+ + IR KEK+ E
Sbjct: 557 EE-------KMQEQEKMRRQEEKIREQ-EEKIREQKEKIRE 589
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 77.4 bits (189), Expect = 1e-13
Identities = 121/605 (20%), Positives = 261/605 (43%), Gaps = 68/605 (11%)
Query: 366 KVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKY- 424
K+ N TN E T D+ ++ +EL+ +H++ K + + Y
Sbjct: 150 KINNGTNPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYY 209
Query: 425 -AEVIEKTSYLMRPEVYRLIN--EEAMVMNYAL--LGNRKALAQLFVNLMESTLQQELDS 479
+++ R + RL + + A + AL + +K A ++ E T +++ S
Sbjct: 210 SQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIE--ELTKERDALS 267
Query: 480 RHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKT-QNVLQQRRLKH 538
++ + + +K A LQ + + SE E+++ +K + L++ +L
Sbjct: 268 LELYRNTITDEELKEKNAKLQEKLQLVESEK--------SEIQLNVKELKRKLERAKL-- 317
Query: 539 LCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLY---EKTWQECLMHV 595
LLP + + L S++ +L + +W RL EK W++
Sbjct: 318 ------LLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ----- 366
Query: 596 QNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTE--WQ 653
++++ +W+ +E+ E + Q + + + K+ E++ + E + Q E W+
Sbjct: 367 ---EEKIQEWEEKIQEQEEKIREQE--EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 421
Query: 654 SSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQ 713
+ +E+ +WE + ++ELE EK EQ + + E + +E +++ +Q ++
Sbjct: 422 KEEKMRRQEEM--MWEKEEK---IRELE-EKMHEQEKIREQEEKRQEE---EKIREQEKR 472
Query: 714 QSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFV 773
Q + + EK+++ + ++ + E + +E + ++E +
Sbjct: 473 QEQEAKMWRQEEKIREQEEKIREQEE---KMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 529
Query: 774 REIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSV 833
+I EQ K + E + ++++ + +K +E+ R +E +
Sbjct: 530 EKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEE--KVWRQEEKI 587
Query: 834 EEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNE 893
E EE+ ++ E +E + Q+++ KM E +E + E+MQ + E E
Sbjct: 588 REQEEKIREQEEKIREQEEMTQEQEE----KMGEQEEKMCEQEEKMQEQEEKMRR---QE 640
Query: 894 ENVKGQGEKKEESEEEDEKEEE---EEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLE 950
E ++ Q +K E EE+ ++EE E+EEK+ E++E+ QEE+ + E+E+K E
Sbjct: 641 EKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK----MQEQEEKMRRQE 696
Query: 951 EIYYE 955
E +E
Sbjct: 697 EKMWE 701
Score = 58.9 bits (141), Expect = 4e-08
Identities = 72/312 (23%), Positives = 138/312 (44%), Gaps = 28/312 (8%)
Query: 660 YFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKET 719
Y Q V+ E +L+ + + K + Q S + Q+ DR +++L ++ D +
Sbjct: 209 YSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVA-TQKKKADRYIEELTKERDALS 267
Query: 720 LAFHLEKVKDY-LKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFE 778
L + + D LK ++ + L+ E E + +KEL + +
Sbjct: 268 LELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQ-LNVKELKRKLERAKLL-----LPQ 321
Query: 779 QNLAGEVIFKFRQPEAHEKPSQKRVKKL----RKKQGSKEDMTRSEESISSGTSTARSVE 834
Q L E ++ ++ Q +V++ R Q +E M R EE I E
Sbjct: 322 QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE------E 375
Query: 835 EVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLN-- 892
+++E+ ++ E E++ Q++K +M KE ++ EEM E+E +
Sbjct: 376 KIQEQEEKIREQ--EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM 433
Query: 893 ---EENVKGQGEKKEESE---EEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKE 946
EE ++ EK E E E++EK +EEE+ + +E+++E+EA+ ++ + E+E+K
Sbjct: 434 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 493
Query: 947 EGLEEIYYEDME 958
EE + E
Sbjct: 494 REQEEKMWRQEE 505
Score = 33.9 bits (76), Expect = 1.3
Identities = 35/161 (21%), Positives = 63/161 (39%), Gaps = 26/161 (16%)
Query: 1326 LWESSENLLTVAEEFYRKEKRPVTRPDCMCDTFDQCAENISKKILEYQSQANKYHNSCLI 1385
+W E + E + +KEK + E I K+ + Q K H+
Sbjct: 525 MWRQEEKIREQEEIWRQKEK------------IHEQEEKIRKQEEKMWRQEEKMHDQ--- 569
Query: 1386 ELRIQIRRFEELLPQVCWLVMENFKEHHWKKFFTSVKEIRGQFEEQQKRLEKRKDKNAQK 1445
+IR EE + W E +E K ++E + EQ++ +++++K ++
Sbjct: 570 --EEKIREQEEKV----WRQEEKIREQEEK-----IREQEEKIREQEEMTQEQEEKMGEQ 618
Query: 1446 LHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEKLEE 1486
QE E +EE+ E + IR +EK+ E
Sbjct: 619 EEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 659
Score = 33.5 bits (75), Expect = 1.7
Identities = 80/399 (20%), Positives = 154/399 (38%), Gaps = 61/399 (15%)
Query: 1091 RLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTW 1150
R+LT + +++ + S L + L +++ + GE E+ LS V T
Sbjct: 194 RILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGE-----LEQALSAVATQ 248
Query: 1151 KEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEAKLDVVTPESF 1210
K+K + I+ L D +S+ ++ NTI D ++ + L+E+ +L V + +S
Sbjct: 249 KKKADRYIEELTKERDALSLE--LYRNTIT-----DEELKEKNAKLQEKLQL-VESEKSE 300
Query: 1211 TQLSRVGKPLIEDPAVDVIRKLLQLPNTKWPTH--HCDKDPSQTGFKRHRCQPENSGKKA 1268
QL+ +++ + R L LP + H K+ K EN
Sbjct: 301 IQLN------VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 354
Query: 1269 VPSASATSAGSLQTTHPPLSHSFTPHP-KPNKMERKYRVLGDKPPPAAEDFKGIILTLLW 1327
+ + K + E K R +K E ++W
Sbjct: 355 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEE--------MMW 406
Query: 1328 ESSENLLTVAEEFYRKEKRPVTRPDCMCDTFDQCAENISKKILEYQSQANKYHNSCLIEL 1387
E E + E + KE++ + + M + +KI E + K H I
Sbjct: 407 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEK--------EEKIRELE---EKMHEQEKIRE 455
Query: 1388 RIQIRRFEELLPQVCWLVMENFKEHHWKKFFTSVKEIRGQFEEQQKRLEKRKDKNAQKLH 1447
+ + R+ EE + + + ++ K + ++IR Q EE+ + E++ + +K+H
Sbjct: 456 QEEKRQEEEKIRE------QEKRQEQEAKMWRQEEKIREQ-EEKIREQEEKMWRQEEKIH 508
Query: 1448 LNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEKLEE 1486
E + EEE+++E + M R +EK+ E
Sbjct: 509 ------------EQEKIREEEKRQEQEEMWR-QEEKIRE 534
Score = 31.6 bits (70), Expect = 6.6
Identities = 32/166 (19%), Positives = 74/166 (44%), Gaps = 7/166 (4%)
Query: 1326 LWESSENLLTVAEEFYRKEKRPVTRPDCMCDTFDQCAENISKKILEYQSQANKYHNSCLI 1385
+W E + E+ ++E++ + + M D ++ E K + Q + + +
Sbjct: 538 IWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEK--VWRQEEKIREQEEKIR 595
Query: 1386 ELRIQIRRFEELLPQVCWLVMENFKE--HHWKKFFTSVKEIRGQFE---EQQKRLEKRKD 1440
E +IR EE+ + + E ++ +K +++R Q E EQ+K++ ++++
Sbjct: 596 EQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEE 655
Query: 1441 KNAQKLHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEKLEE 1486
K ++ + E E +EE+ +E + +R +EK+ E
Sbjct: 656 KIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 701
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 73.9 bits (180), Expect = 1e-12
Identities = 149/746 (19%), Positives = 305/746 (40%), Gaps = 99/746 (13%)
Query: 267 VLHREKERAKREKAR----ESENTIAAREVRGLMDTIVPEKISTSTFQRQ---AEHKRKS 319
+LH + R + E+ R ++E A+++ L + + E+ + Q + AE K K
Sbjct: 923 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982
Query: 320 YESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQ 379
E + ++ ++ KE + L L E ++ N LK ++++ + + +
Sbjct: 983 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV- 1041
Query: 380 ALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRPE- 438
RL ++ +EL++ LE +D + + A++ E L + E
Sbjct: 1042 -----------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090
Query: 439 ----VYRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWK--- 491
+++E N AL R+ + S LQ++LDS + + K
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHI------SDLQEDLDSERAARNKAEKQKRDL 1144
Query: 492 ALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNV----------LQQRRLKHLCT 541
+ EAL + + S + +E EV + + + +Q+ R KH
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 542 ICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQ 601
+ +L + Q ++L+ + L+ + D +R+L + V++ KK+
Sbjct: 1205 VEEL---TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL-----GQAKQEVEHKKKK 1256
Query: 602 L------LDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSS 655
L L K E A +N V LQ +VE +L+++ E A + +
Sbjct: 1257 LEAQVQELQSKCSDGERARAELND----KVHKLQNEVESVTGMLNEA-EGKAIKLAKDVA 1311
Query: 656 HLFKYFQEVVQLWEAHQSELLVQELELEKRMEQ-HRQKHSLESQVQEA-----HLDRLLD 709
L Q+ +L + E Q+L + ++ Q +++SL+ Q+ E +L+R +
Sbjct: 1312 SLSSQLQDTQELLQ----EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367
Query: 710 QLR-QQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALS 768
L Q SD + + L+ K R++ LT++ E A K L + L
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK-LEKTKNRLQ 1426
Query: 769 QYF--FVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSE--ESIS 824
Q V ++ Q +++ + + K + K + D +E E +
Sbjct: 1427 QELDDLVVDLDNQR---QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 825 SGTSTARSVEEVEEENDQ----------EMESFIT-EEVLG------QQKKSPLHAKMDE 867
S AR++EE E ++ EME ++ ++ +G ++ K L +M+E
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 868 SKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKK-EESEEEDEKEEEEEEEKLEEEKE 926
K + +E+Q + L +N + +KGQ E+ + +E++E++ + + +L E +
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603
Query: 927 EKEAQEEQESLSVGEEEDKEEGLEEI 952
E E + +Q +L+ ++ E L+++
Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDL 1629
Score = 61.2 bits (147), Expect = 8e-09
Identities = 194/973 (19%), Positives = 371/973 (38%), Gaps = 161/973 (16%)
Query: 358 EEMNRLFLKVENDTNLEDYTIQALLELW---DKVAGRLLLRKQEIKELDEALHSLEF--- 411
+E+ + ++ + NL +QA EL+ +++ RL +KQE++E+ LH +E
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI---LHEMEARLE 932
Query: 412 ---SRTDKLKSVLKKYA-EVIEKTSYLMRPEVYR---------------LINEEAMVM-- 450
R +L++ KK A ++++ L E R + +E +VM
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 451 -NYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASE 509
N L RK L + +L + ++E + K L++ E M S
Sbjct: 993 QNNKLSKERKLLEERISDLTTNLAEEE--------------EKAKNLTKLKNKHESMIS- 1037
Query: 510 SIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKEL 569
ELEV LK + +Q L+ L + + + Q+ + + + L +L
Sbjct: 1038 ----------ELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQL 1085
Query: 570 DTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQ 629
+ + L ++ Q+ N K++ + + + E L ++ + Q
Sbjct: 1086 AKKEEELQAALARLDDEIAQK-----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 630 GK-VEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQ 688
+ + E+LE L E D T Q K QEV L +A E E ++++ ++
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Query: 689 HRQK-HSLESQVQE-----AHLD-----------------RLLDQLRQQSD--KETLAFH 723
H Q L Q+++ A+LD R+L Q +Q+ + K+ L
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 724 LEKVK--------------DYLKNMKSRYECFHTLLTKEVMEYPAIML-KELNSYSSALS 768
+++++ D + +++ E +L + E AI L K++ S SS L
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGKAIKLAKDVASLSSQLQ 1318
Query: 769 Q-YFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRV-KKLRKKQGSKE-------DMTRS 819
++E Q L V K RQ E Q ++ +++ KQ + ++ S
Sbjct: 1319 DTQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 820 EESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEM 879
++ + ST ++EE ++ +E+E+ + ++K+ + K++++K Q L+++
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQ----YEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 880 QVEREGSLNPSLNEENVKGQ------GEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEE 933
V+ + N E + + EK S+ DE++ E E + +E K A+
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492
Query: 934 QESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFIND 993
+E+L EE ++ + + ED+ S G E E +++ T
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH-----ELEKSKRALETQMEEMKTQ 1547
Query: 994 TSSAKFIEQVTIPSRLILEIKKQLF-----------SEGGNFSPKEINSLCSRLEKEAAR 1042
+ Q T ++L LE+ Q E +++ E E
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 1043 IELVESVIMLNMEKLENEYLD---QANDVINKFESKFHNLSVDLIFIEKIQRLLTNLQV- 1098
++ +KLE + D QA+ I E L ++ QR L + +
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1667
Query: 1099 --KIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGE---KTTVTTEELLS------FV 1147
+I ++ + L L QLQ + + +R + + EEL S +
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1727
Query: 1148 QTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEAKLDVVTP 1207
Q K +L RI L L+ ++ + K ++ + S L E
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL---SNELATERSTAQKNE 1784
Query: 1208 ESFTQLSRVGKPL 1220
+ QL R K L
Sbjct: 1785 SARQQLERQNKEL 1797
Score = 52.4 bits (124), Expect = 4e-06
Identities = 148/717 (20%), Positives = 275/717 (38%), Gaps = 95/717 (13%)
Query: 242 EGEVMSPRQQKWMHSLPNDWIMENPVLHREKERAKREKARESENTIAAREVRGLMDTIVP 301
+GE +H L N+ +L+ + +A + + + ++ + L+
Sbjct: 1270 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 302 EKISTSTFQRQAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGLFLK-----KLTES 356
+K++ ST RQ E +R S + L E + + + L + K E+
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 357 DEEMNRLFLK-VENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSR-- 413
EE + F K +EN T + A +L +K RL +ELD+ + L+ R
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKL-EKTKNRLQ------QELDDLVVDLDNQRQL 1442
Query: 414 TDKLKSVLKKYAEVIEKTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQLFVNLMESTL 473
L+ +K+ +++ + + + +E A KAL+ + L
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISS----KYADERDRAEAEAREKETKALS------LARAL 1492
Query: 474 QQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQ 533
++ L+++ L T K LK E S+ +++H + LE ++
Sbjct: 1493 EEALEAKEE---LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM----- 1544
Query: 534 RRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLM 593
KTQL E L + V+ M ++ +E+ Q
Sbjct: 1545 ------------------KTQLEELEDELQATEDAKLRLEVN-MQALKGQFERDLQA--R 1583
Query: 594 HVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQ 653
QN +K+ + E E E + + A + K+E DL+ L+ ++ E
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1643
Query: 654 SSHL------FKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLD-R 706
L K FQ ++ A + E+ E EK+ + SLE+ + + D
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK------SLEADLMQLQEDLA 1697
Query: 707 LLDQLRQQSD--KETLAFHLEKV---KDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELN 761
++ R+Q+D KE LA L ++ L++ K R E L +E+ E M +
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
Query: 762 SYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEE 821
A Q E LA E + A ++ +++ K+LR K E +S+
Sbjct: 1758 RVRKATQQ----AEQLSNELATERSTAQKNESARQQ-LERQNKELRSKLHEMEGAVKSKF 1812
Query: 822 SISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEE--M 879
+ A+ + ++EE+ +QE ++K++ + + K+ L+E +
Sbjct: 1813 KSTIAALEAK-IAQLEEQVEQE----------AREKQAATKSLKQKDKK-----LKEILL 1856
Query: 880 QVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQES 936
QVE E + E+ KG K+ + +E EEE + K ++E E ES
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Score = 51.6 bits (122), Expect = 6e-06
Identities = 156/779 (20%), Positives = 307/779 (39%), Gaps = 128/779 (16%)
Query: 271 EKERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALASFQEE 330
+ ERA R KA + + + E + T + + + ++ Q++ KR+ + L +E
Sbjct: 1128 DSERAARNKAEKQKRDLG--EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 331 IAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVE-NDTNLEDYTIQALLELWDKVA 389
+ + + +++LTE E+ R ++ N LE EL +V
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL--RVL 1243
Query: 390 GRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRP--EVYRLINE-E 446
G+ KQE++ + L + K + AE+ +K L V ++NE E
Sbjct: 1244 GQA---KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 447 AMVMNYAL-LGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEA-----LLQ 500
+ A + + + Q L++ +Q+L+ + + L + +L+ + Q
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360
Query: 501 SFSEFMASESIHTPPAVTKELEVMLKTQNVLQ------QRRLKHLCTICDLLPPSYSKTQ 554
+ +++ +I + K+L+ T L+ Q+ +++L + +Y K +
Sbjct: 1361 NLERHISTLNIQLSDS-KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419
Query: 555 LTEWHSSLNSLNKELDTYHVDCMMWIRLLY-----EKTWQECLMHVQNCKKQLLDWKAFT 609
T+ N L +ELD VD +L+ ++ + + L +N + D +
Sbjct: 1420 KTK-----NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474
Query: 610 EEEA---ETLVNQFFFQMVGALQGKVE------------EDL-----------ELLDKSF 643
E EA ET + AL+ K E EDL L+KS
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534
Query: 644 ETLADQTEWQSSHLFKYFQEVVQLWEAH-QSELLVQELE--------------LEKRMEQ 688
L Q E + L + E+ +A + E+ +Q L+ EKR +
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594
Query: 689 HRQKHSLESQVQEAHLDRLL------------DQLRQQSD-----KETLAFHLEKVKDYL 731
RQ H E+++++ R L L Q+D +E L K++ +
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Query: 732 KNMK--------SRYECFHTLLTKEV----MEYPAIMLKE-LNSYSSALSQYFFVREIFE 778
K+ + SR E F T E +E + L+E L + A Q +E
Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 779 QNLAGEVIFKFRQPEAHEKPSQKRV----KKLRKKQGSKEDM-------TRSEESISSGT 827
+ LA + + + ++ + R+ ++L ++QG+ E M T+ E +S+
Sbjct: 1715 EELASSLSGR-NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 828 STARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSL 887
+T RS + E Q++E ++ L +K+ E EG+++ + + +
Sbjct: 1774 ATERSTAQKNESARQQLE----------RQNKELRSKLHEM-EGAVKSKFKSTIAALEAK 1822
Query: 888 NPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKE 946
L E+ + EK+ ++ +K+++ +E L+ E E K A++ +E G K+
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1881
Score = 50.4 bits (119), Expect = 1e-05
Identities = 129/628 (20%), Positives = 253/628 (40%), Gaps = 109/628 (17%)
Query: 362 RLFLKVEN--DTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRT---DK 416
RLF KV+ ++ +QA + K R + E+KEL++ L + ++
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 417 LKSVLKKYAEVIEKTSYLM--RPEVYRLINE------EAMVMNYALLGNRKALAQLFVNL 468
L++ + YAE E L + E+ +++E E L RK +AQ ++L
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 469 MESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQ 528
E ++E A +++ L+ + + + V + L +
Sbjct: 956 EEQLEEEE---------------AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1000
Query: 529 NVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTW 588
L + R+ L T +L LT+ + S+ EL+ +RL E
Sbjct: 1001 RKLLEERISDLTT--NLAEEEEKAKNLTKLKNKHESMISELE---------VRLKKE--- 1046
Query: 589 QECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEE-DLELLDKSFETLA 647
+ +++L K E +A F + + LQ ++ E ++L K E A
Sbjct: 1047 -------EKSRQELEKLKRKLEGDASD-----FHEQIADLQAQIAELKMQLAKKEEELQA 1094
Query: 648 -----DQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEK--RMEQHRQKHSLESQVQ 700
D Q ++ K +E+ E H S+L ++L+ E+ R + +QK L ++
Sbjct: 1095 ALARLDDEIAQKNNALKKIREL----EGHISDLQ-EDLDSERAARNKAEKQKRDLGEEL- 1148
Query: 701 EAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKEL 760
EA L D L + ++ L E+ LK H +E+ + A ++EL
Sbjct: 1149 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208
Query: 761 NSYSSALSQYFFVREIFEQN----------LAGE--VIFKFRQPEAHEKPS-QKRVKKLR 807
+ L Q+ + ++N LAGE V+ + +Q H+K + +V++L+
Sbjct: 1209 ---TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 808 KKQGSKE-----------DMTRSEESISSGTSTA--RSVEEVEEENDQEMESFITEEVLG 854
K E + ES++ + A ++++ ++ + T+E+L
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 855 QQKKSPLHAKMD----ESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKE------ 904
++ + L+ E + S+Q + ++E + +L ++ N++ KK+
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385
Query: 905 --ESEEEDEKEEEEEEEKLEEEKEEKEA 930
E+ EE +K ++E E L ++ EEK A
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAA 1413
Score = 44.3 bits (103), Expect = 0.001
Identities = 90/404 (22%), Positives = 158/404 (39%), Gaps = 81/404 (20%)
Query: 802 RVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQ---QKK 858
+VK L + +E+M E+ + + E +E +Q+ E+ L Q Q +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899
Query: 859 SPLHAKMDESK---EGSIQGLEEMQVEREGSLNPSLNEENVKGQ---GEKKEESEEEDEK 912
+ L+A+ +E + Q LEE+ E E L EE +GQ E+K+ +++ +
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLE----EEEDRGQQLQAERKKMAQQMLDL 955
Query: 913 EEEEEEE-------------------KLEEE------------KEEKEAQEEQESL--SV 939
EE+ EEE KLE+E KE K +E L ++
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 940 GEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKF 999
EEE+K + L ++ ++ IS +EE R+ D S F
Sbjct: 1016 AEEEEKAKNLTKL--KNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASD--F 1067
Query: 1000 IEQVTIPSRLILEIKKQLFSEGGNFSPKEINSLCSRLEKEAARIELVESVIMLNMEKLE- 1058
EQ+ I E+K QL + +E+ + +RL+ E A+ ++ + + +LE
Sbjct: 1068 HEQIADLQAQIAELKMQLAKK-----EEELQAALARLDDEIAQ----KNNALKKIRELEG 1118
Query: 1059 -----NEYLDQANDVINKFESKFHNLSVDLIFIEKIQRLLTNLQVKIKCQV------AKS 1107
E LD NK E + +L E+++ L T L+ + AK
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLG------EELEALKTELEDTLDSTATQQELRAKR 1172
Query: 1108 NSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTWK 1151
+ L +L + + + +K EEL ++ +K
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1216
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 73.9 bits (180), Expect = 1e-12
Identities = 149/746 (19%), Positives = 305/746 (40%), Gaps = 99/746 (13%)
Query: 267 VLHREKERAKREKAR----ESENTIAAREVRGLMDTIVPEKISTSTFQRQ---AEHKRKS 319
+LH + R + E+ R ++E A+++ L + + E+ + Q + AE K K
Sbjct: 930 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989
Query: 320 YESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQ 379
E + ++ ++ KE + L L E ++ N LK ++++ + + +
Sbjct: 990 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV- 1048
Query: 380 ALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRPE- 438
RL ++ +EL++ LE +D + + A++ E L + E
Sbjct: 1049 -----------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097
Query: 439 ----VYRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWK--- 491
+++E N AL R+ + S LQ++LDS + + K
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHI------SDLQEDLDSERAARNKAEKQKRDL 1151
Query: 492 ALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNV----------LQQRRLKHLCT 541
+ EAL + + S + +E EV + + + +Q+ R KH
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 542 ICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQ 601
+ +L + Q ++L+ + L+ + D +R+L + V++ KK+
Sbjct: 1212 VEEL---TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL-----GQAKQEVEHKKKK 1263
Query: 602 L------LDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSS 655
L L K E A +N V LQ +VE +L+++ E A + +
Sbjct: 1264 LEAQVQELQSKCSDGERARAELND----KVHKLQNEVESVTGMLNEA-EGKAIKLAKDVA 1318
Query: 656 HLFKYFQEVVQLWEAHQSELLVQELELEKRMEQ-HRQKHSLESQVQEA-----HLDRLLD 709
L Q+ +L + E Q+L + ++ Q +++SL+ Q+ E +L+R +
Sbjct: 1319 SLSSQLQDTQELLQ----EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374
Query: 710 QLR-QQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALS 768
L Q SD + + L+ K R++ LT++ E A K L + L
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK-LEKTKNRLQ 1433
Query: 769 QYF--FVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSE--ESIS 824
Q V ++ Q +++ + + K + K + D +E E +
Sbjct: 1434 QELDDLVVDLDNQR---QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 825 SGTSTARSVEEVEEENDQ----------EMESFIT-EEVLG------QQKKSPLHAKMDE 867
S AR++EE E ++ EME ++ ++ +G ++ K L +M+E
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 868 SKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKK-EESEEEDEKEEEEEEEKLEEEKE 926
K + +E+Q + L +N + +KGQ E+ + +E++E++ + + +L E +
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610
Query: 927 EKEAQEEQESLSVGEEEDKEEGLEEI 952
E E + +Q +L+ ++ E L+++
Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDL 1636
Score = 61.2 bits (147), Expect = 8e-09
Identities = 194/973 (19%), Positives = 371/973 (38%), Gaps = 161/973 (16%)
Query: 358 EEMNRLFLKVENDTNLEDYTIQALLELW---DKVAGRLLLRKQEIKELDEALHSLEF--- 411
+E+ + ++ + NL +QA EL+ +++ RL +KQE++E+ LH +E
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI---LHEMEARLE 939
Query: 412 ---SRTDKLKSVLKKYA-EVIEKTSYLMRPEVYR---------------LINEEAMVM-- 450
R +L++ KK A ++++ L E R + +E +VM
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 451 -NYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASE 509
N L RK L + +L + ++E + K L++ E M S
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEE--------------EKAKNLTKLKNKHESMIS- 1044
Query: 510 SIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKEL 569
ELEV LK + +Q L+ L + + + Q+ + + + L +L
Sbjct: 1045 ----------ELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQL 1092
Query: 570 DTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQ 629
+ + L ++ Q+ N K++ + + + E L ++ + Q
Sbjct: 1093 AKKEEELQAALARLDDEIAQK-----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 630 GK-VEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQ 688
+ + E+LE L E D T Q K QEV L +A E E ++++ ++
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Query: 689 HRQK-HSLESQVQE-----AHLD-----------------RLLDQLRQQSD--KETLAFH 723
H Q L Q+++ A+LD R+L Q +Q+ + K+ L
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 724 LEKVK--------------DYLKNMKSRYECFHTLLTKEVMEYPAIML-KELNSYSSALS 768
+++++ D + +++ E +L + E AI L K++ S SS L
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGKAIKLAKDVASLSSQLQ 1325
Query: 769 Q-YFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRV-KKLRKKQGSKE-------DMTRS 819
++E Q L V K RQ E Q ++ +++ KQ + ++ S
Sbjct: 1326 DTQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 820 EESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEM 879
++ + ST ++EE ++ +E+E+ + ++K+ + K++++K Q L+++
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQ----YEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 880 QVEREGSLNPSLNEENVKGQ------GEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEE 933
V+ + N E + + EK S+ DE++ E E + +E K A+
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499
Query: 934 QESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFIND 993
+E+L EE ++ + + ED+ S G E E +++ T
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH-----ELEKSKRALETQMEEMKTQ 1554
Query: 994 TSSAKFIEQVTIPSRLILEIKKQLF-----------SEGGNFSPKEINSLCSRLEKEAAR 1042
+ Q T ++L LE+ Q E +++ E E
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 1043 IELVESVIMLNMEKLENEYLD---QANDVINKFESKFHNLSVDLIFIEKIQRLLTNLQV- 1098
++ +KLE + D QA+ I E L ++ QR L + +
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1674
Query: 1099 --KIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGE---KTTVTTEELLS------FV 1147
+I ++ + L L QLQ + + +R + + EEL S +
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1734
Query: 1148 QTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEAKLDVVTP 1207
Q K +L RI L L+ ++ + K ++ + S L E
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL---SNELATERSTAQKNE 1791
Query: 1208 ESFTQLSRVGKPL 1220
+ QL R K L
Sbjct: 1792 SARQQLERQNKEL 1804
Score = 52.4 bits (124), Expect = 4e-06
Identities = 148/717 (20%), Positives = 275/717 (38%), Gaps = 95/717 (13%)
Query: 242 EGEVMSPRQQKWMHSLPNDWIMENPVLHREKERAKREKARESENTIAAREVRGLMDTIVP 301
+GE +H L N+ +L+ + +A + + + ++ + L+
Sbjct: 1277 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 302 EKISTSTFQRQAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGLFLK-----KLTES 356
+K++ ST RQ E +R S + L E + + + L + K E+
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 357 DEEMNRLFLK-VENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSR-- 413
EE + F K +EN T + A +L +K RL +ELD+ + L+ R
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKL-EKTKNRLQ------QELDDLVVDLDNQRQL 1449
Query: 414 TDKLKSVLKKYAEVIEKTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQLFVNLMESTL 473
L+ +K+ +++ + + + +E A KAL+ + L
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISS----KYADERDRAEAEAREKETKALS------LARAL 1499
Query: 474 QQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQ 533
++ L+++ L T K LK E S+ +++H + LE ++
Sbjct: 1500 EEALEAKEE---LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM----- 1551
Query: 534 RRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLM 593
KTQL E L + V+ M ++ +E+ Q
Sbjct: 1552 ------------------KTQLEELEDELQATEDAKLRLEVN-MQALKGQFERDLQA--R 1590
Query: 594 HVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQ 653
QN +K+ + E E E + + A + K+E DL+ L+ ++ E
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650
Query: 654 SSHL------FKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLD-R 706
L K FQ ++ A + E+ E EK+ + SLE+ + + D
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK------SLEADLMQLQEDLA 1704
Query: 707 LLDQLRQQSD--KETLAFHLEKV---KDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELN 761
++ R+Q+D KE LA L ++ L++ K R E L +E+ E M +
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Query: 762 SYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEE 821
A Q E LA E + A ++ +++ K+LR K E +S+
Sbjct: 1765 RVRKATQQ----AEQLSNELATERSTAQKNESARQQ-LERQNKELRSKLHEMEGAVKSKF 1819
Query: 822 SISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEE--M 879
+ A+ + ++EE+ +QE ++K++ + + K+ L+E +
Sbjct: 1820 KSTIAALEAK-IAQLEEQVEQE----------AREKQAATKSLKQKDKK-----LKEILL 1863
Query: 880 QVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQES 936
QVE E + E+ KG K+ + +E EEE + K ++E E ES
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Score = 51.6 bits (122), Expect = 6e-06
Identities = 156/779 (20%), Positives = 307/779 (39%), Gaps = 128/779 (16%)
Query: 271 EKERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALASFQEE 330
+ ERA R KA + + + E + T + + + ++ Q++ KR+ + L +E
Sbjct: 1135 DSERAARNKAEKQKRDLG--EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Query: 331 IAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVE-NDTNLEDYTIQALLELWDKVA 389
+ + + +++LTE E+ R ++ N LE EL +V
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL--RVL 1250
Query: 390 GRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRP--EVYRLINE-E 446
G+ KQE++ + L + K + AE+ +K L V ++NE E
Sbjct: 1251 GQA---KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 447 AMVMNYAL-LGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEA-----LLQ 500
+ A + + + Q L++ +Q+L+ + + L + +L+ + Q
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Query: 501 SFSEFMASESIHTPPAVTKELEVMLKTQNVLQ------QRRLKHLCTICDLLPPSYSKTQ 554
+ +++ +I + K+L+ T L+ Q+ +++L + +Y K +
Sbjct: 1368 NLERHISTLNIQLSDS-KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
Query: 555 LTEWHSSLNSLNKELDTYHVDCMMWIRLLY-----EKTWQECLMHVQNCKKQLLDWKAFT 609
T+ N L +ELD VD +L+ ++ + + L +N + D +
Sbjct: 1427 KTK-----NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481
Query: 610 EEEA---ETLVNQFFFQMVGALQGKVE------------EDL-----------ELLDKSF 643
E EA ET + AL+ K E EDL L+KS
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541
Query: 644 ETLADQTEWQSSHLFKYFQEVVQLWEAH-QSELLVQELE--------------LEKRMEQ 688
L Q E + L + E+ +A + E+ +Q L+ EKR +
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601
Query: 689 HRQKHSLESQVQEAHLDRLL------------DQLRQQSD-----KETLAFHLEKVKDYL 731
RQ H E+++++ R L L Q+D +E L K++ +
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Query: 732 KNMK--------SRYECFHTLLTKEV----MEYPAIMLKE-LNSYSSALSQYFFVREIFE 778
K+ + SR E F T E +E + L+E L + A Q +E
Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 779 QNLAGEVIFKFRQPEAHEKPSQKRV----KKLRKKQGSKEDM-------TRSEESISSGT 827
+ LA + + + ++ + R+ ++L ++QG+ E M T+ E +S+
Sbjct: 1722 EELASSLSGR-NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 828 STARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSL 887
+T RS + E Q++E ++ L +K+ E EG+++ + + +
Sbjct: 1781 ATERSTAQKNESARQQLE----------RQNKELRSKLHEM-EGAVKSKFKSTIAALEAK 1829
Query: 888 NPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKE 946
L E+ + EK+ ++ +K+++ +E L+ E E K A++ +E G K+
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1888
Score = 50.4 bits (119), Expect = 1e-05
Identities = 129/628 (20%), Positives = 253/628 (40%), Gaps = 109/628 (17%)
Query: 362 RLFLKVEN--DTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRT---DK 416
RLF KV+ ++ +QA + K R + E+KEL++ L + ++
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 417 LKSVLKKYAEVIEKTSYLM--RPEVYRLINE------EAMVMNYALLGNRKALAQLFVNL 468
L++ + YAE E L + E+ +++E E L RK +AQ ++L
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 469 MESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQ 528
E ++E A +++ L+ + + + V + L +
Sbjct: 963 EEQLEEEE---------------AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1007
Query: 529 NVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTW 588
L + R+ L T +L LT+ + S+ EL+ +RL E
Sbjct: 1008 RKLLEERISDLTT--NLAEEEEKAKNLTKLKNKHESMISELE---------VRLKKE--- 1053
Query: 589 QECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEE-DLELLDKSFETLA 647
+ +++L K E +A F + + LQ ++ E ++L K E A
Sbjct: 1054 -------EKSRQELEKLKRKLEGDASD-----FHEQIADLQAQIAELKMQLAKKEEELQA 1101
Query: 648 -----DQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEK--RMEQHRQKHSLESQVQ 700
D Q ++ K +E+ E H S+L ++L+ E+ R + +QK L ++
Sbjct: 1102 ALARLDDEIAQKNNALKKIREL----EGHISDLQ-EDLDSERAARNKAEKQKRDLGEEL- 1155
Query: 701 EAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKEL 760
EA L D L + ++ L E+ LK H +E+ + A ++EL
Sbjct: 1156 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215
Query: 761 NSYSSALSQYFFVREIFEQN----------LAGE--VIFKFRQPEAHEKPS-QKRVKKLR 807
+ L Q+ + ++N LAGE V+ + +Q H+K + +V++L+
Sbjct: 1216 ---TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 808 KKQGSKE-----------DMTRSEESISSGTSTA--RSVEEVEEENDQEMESFITEEVLG 854
K E + ES++ + A ++++ ++ + T+E+L
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 855 QQKKSPLHAKMD----ESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKE------ 904
++ + L+ E + S+Q + ++E + +L ++ N++ KK+
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392
Query: 905 --ESEEEDEKEEEEEEEKLEEEKEEKEA 930
E+ EE +K ++E E L ++ EEK A
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAA 1420
Score = 44.3 bits (103), Expect = 0.001
Identities = 90/404 (22%), Positives = 158/404 (39%), Gaps = 81/404 (20%)
Query: 802 RVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQ---QKK 858
+VK L + +E+M E+ + + E +E +Q+ E+ L Q Q +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 859 SPLHAKMDESK---EGSIQGLEEMQVEREGSLNPSLNEENVKGQ---GEKKEESEEEDEK 912
+ L+A+ +E + Q LEE+ E E L EE +GQ E+K+ +++ +
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLE----EEEDRGQQLQAERKKMAQQMLDL 962
Query: 913 EEEEEEE-------------------KLEEE------------KEEKEAQEEQESL--SV 939
EE+ EEE KLE+E KE K +E L ++
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 940 GEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKF 999
EEE+K + L ++ ++ IS +EE R+ D S F
Sbjct: 1023 AEEEEKAKNLTKL--KNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASD--F 1074
Query: 1000 IEQVTIPSRLILEIKKQLFSEGGNFSPKEINSLCSRLEKEAARIELVESVIMLNMEKLE- 1058
EQ+ I E+K QL + +E+ + +RL+ E A+ ++ + + +LE
Sbjct: 1075 HEQIADLQAQIAELKMQLAKK-----EEELQAALARLDDEIAQ----KNNALKKIRELEG 1125
Query: 1059 -----NEYLDQANDVINKFESKFHNLSVDLIFIEKIQRLLTNLQVKIKCQV------AKS 1107
E LD NK E + +L E+++ L T L+ + AK
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLG------EELEALKTELEDTLDSTATQQELRAKR 1179
Query: 1108 NSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTWK 1151
+ L +L + + + +K EEL ++ +K
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1223
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 73.9 bits (180), Expect = 1e-12
Identities = 149/746 (19%), Positives = 305/746 (40%), Gaps = 99/746 (13%)
Query: 267 VLHREKERAKREKAR----ESENTIAAREVRGLMDTIVPEKISTSTFQRQ---AEHKRKS 319
+LH + R + E+ R ++E A+++ L + + E+ + Q + AE K K
Sbjct: 930 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989
Query: 320 YESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQ 379
E + ++ ++ KE + L L E ++ N LK ++++ + + +
Sbjct: 990 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV- 1048
Query: 380 ALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRPE- 438
RL ++ +EL++ LE +D + + A++ E L + E
Sbjct: 1049 -----------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097
Query: 439 ----VYRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWK--- 491
+++E N AL R+ + S LQ++LDS + + K
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHI------SDLQEDLDSERAARNKAEKQKRDL 1151
Query: 492 ALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNV----------LQQRRLKHLCT 541
+ EAL + + S + +E EV + + + +Q+ R KH
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 542 ICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQ 601
+ +L + Q ++L+ + L+ + D +R+L + V++ KK+
Sbjct: 1212 VEEL---TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL-----GQAKQEVEHKKKK 1263
Query: 602 L------LDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSS 655
L L K E A +N V LQ +VE +L+++ E A + +
Sbjct: 1264 LEAQVQELQSKCSDGERARAELND----KVHKLQNEVESVTGMLNEA-EGKAIKLAKDVA 1318
Query: 656 HLFKYFQEVVQLWEAHQSELLVQELELEKRMEQ-HRQKHSLESQVQEA-----HLDRLLD 709
L Q+ +L + E Q+L + ++ Q +++SL+ Q+ E +L+R +
Sbjct: 1319 SLSSQLQDTQELLQ----EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374
Query: 710 QLR-QQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALS 768
L Q SD + + L+ K R++ LT++ E A K L + L
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK-LEKTKNRLQ 1433
Query: 769 QYF--FVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSE--ESIS 824
Q V ++ Q +++ + + K + K + D +E E +
Sbjct: 1434 QELDDLVVDLDNQR---QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 825 SGTSTARSVEEVEEENDQ----------EMESFIT-EEVLG------QQKKSPLHAKMDE 867
S AR++EE E ++ EME ++ ++ +G ++ K L +M+E
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 868 SKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKK-EESEEEDEKEEEEEEEKLEEEKE 926
K + +E+Q + L +N + +KGQ E+ + +E++E++ + + +L E +
Sbjct: 1551 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610
Query: 927 EKEAQEEQESLSVGEEEDKEEGLEEI 952
E E + +Q +L+ ++ E L+++
Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDL 1636
Score = 61.2 bits (147), Expect = 8e-09
Identities = 194/973 (19%), Positives = 371/973 (38%), Gaps = 161/973 (16%)
Query: 358 EEMNRLFLKVENDTNLEDYTIQALLELW---DKVAGRLLLRKQEIKELDEALHSLEF--- 411
+E+ + ++ + NL +QA EL+ +++ RL +KQE++E+ LH +E
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI---LHEMEARLE 939
Query: 412 ---SRTDKLKSVLKKYA-EVIEKTSYLMRPEVYR---------------LINEEAMVM-- 450
R +L++ KK A ++++ L E R + +E +VM
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 451 -NYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASE 509
N L RK L + +L + ++E + K L++ E M S
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEE--------------EKAKNLTKLKNKHESMIS- 1044
Query: 510 SIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKEL 569
ELEV LK + +Q L+ L + + + Q+ + + + L +L
Sbjct: 1045 ----------ELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQL 1092
Query: 570 DTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQ 629
+ + L ++ Q+ N K++ + + + E L ++ + Q
Sbjct: 1093 AKKEEELQAALARLDDEIAQK-----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 630 GK-VEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQ 688
+ + E+LE L E D T Q K QEV L +A E E ++++ ++
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Query: 689 HRQK-HSLESQVQE-----AHLD-----------------RLLDQLRQQSD--KETLAFH 723
H Q L Q+++ A+LD R+L Q +Q+ + K+ L
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 724 LEKVK--------------DYLKNMKSRYECFHTLLTKEVMEYPAIML-KELNSYSSALS 768
+++++ D + +++ E +L + E AI L K++ S SS L
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGKAIKLAKDVASLSSQLQ 1325
Query: 769 Q-YFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRV-KKLRKKQGSKE-------DMTRS 819
++E Q L V K RQ E Q ++ +++ KQ + ++ S
Sbjct: 1326 DTQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 820 EESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEM 879
++ + ST ++EE ++ +E+E+ + ++K+ + K++++K Q L+++
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQ----YEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 880 QVEREGSLNPSLNEENVKGQ------GEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEE 933
V+ + N E + + EK S+ DE++ E E + +E K A+
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499
Query: 934 QESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFIND 993
+E+L EE ++ + + ED+ S G E E +++ T
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH-----ELEKSKRALETQMEEMKTQ 1554
Query: 994 TSSAKFIEQVTIPSRLILEIKKQLF-----------SEGGNFSPKEINSLCSRLEKEAAR 1042
+ Q T ++L LE+ Q E +++ E E
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 1043 IELVESVIMLNMEKLENEYLD---QANDVINKFESKFHNLSVDLIFIEKIQRLLTNLQV- 1098
++ +KLE + D QA+ I E L ++ QR L + +
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1674
Query: 1099 --KIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGE---KTTVTTEELLS------FV 1147
+I ++ + L L QLQ + + +R + + EEL S +
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1734
Query: 1148 QTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEAKLDVVTP 1207
Q K +L RI L L+ ++ + K ++ + S L E
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL---SNELATERSTAQKNE 1791
Query: 1208 ESFTQLSRVGKPL 1220
+ QL R K L
Sbjct: 1792 SARQQLERQNKEL 1804
Score = 52.4 bits (124), Expect = 4e-06
Identities = 148/717 (20%), Positives = 275/717 (38%), Gaps = 95/717 (13%)
Query: 242 EGEVMSPRQQKWMHSLPNDWIMENPVLHREKERAKREKARESENTIAAREVRGLMDTIVP 301
+GE +H L N+ +L+ + +A + + + ++ + L+
Sbjct: 1277 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 302 EKISTSTFQRQAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGLFLK-----KLTES 356
+K++ ST RQ E +R S + L E + + + L + K E+
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 357 DEEMNRLFLK-VENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSR-- 413
EE + F K +EN T + A +L +K RL +ELD+ + L+ R
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKL-EKTKNRLQ------QELDDLVVDLDNQRQL 1449
Query: 414 TDKLKSVLKKYAEVIEKTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQLFVNLMESTL 473
L+ +K+ +++ + + + +E A KAL+ + L
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISS----KYADERDRAEAEAREKETKALS------LARAL 1499
Query: 474 QQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQ 533
++ L+++ L T K LK E S+ +++H + LE ++
Sbjct: 1500 EEALEAKEE---LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM----- 1551
Query: 534 RRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLM 593
KTQL E L + V+ M ++ +E+ Q
Sbjct: 1552 ------------------KTQLEELEDELQATEDAKLRLEVN-MQALKGQFERDLQA--R 1590
Query: 594 HVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQ 653
QN +K+ + E E E + + A + K+E DL+ L+ ++ E
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650
Query: 654 SSHL------FKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLD-R 706
L K FQ ++ A + E+ E EK+ + SLE+ + + D
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK------SLEADLMQLQEDLA 1704
Query: 707 LLDQLRQQSD--KETLAFHLEKV---KDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELN 761
++ R+Q+D KE LA L ++ L++ K R E L +E+ E M +
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Query: 762 SYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEE 821
A Q E LA E + A ++ +++ K+LR K E +S+
Sbjct: 1765 RVRKATQQ----AEQLSNELATERSTAQKNESARQQ-LERQNKELRSKLHEMEGAVKSKF 1819
Query: 822 SISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEE--M 879
+ A+ + ++EE+ +QE ++K++ + + K+ L+E +
Sbjct: 1820 KSTIAALEAK-IAQLEEQVEQE----------AREKQAATKSLKQKDKK-----LKEILL 1863
Query: 880 QVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQES 936
QVE E + E+ KG K+ + +E EEE + K ++E E ES
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Score = 51.6 bits (122), Expect = 6e-06
Identities = 156/779 (20%), Positives = 307/779 (39%), Gaps = 128/779 (16%)
Query: 271 EKERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALASFQEE 330
+ ERA R KA + + + E + T + + + ++ Q++ KR+ + L +E
Sbjct: 1135 DSERAARNKAEKQKRDLG--EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Query: 331 IAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVE-NDTNLEDYTIQALLELWDKVA 389
+ + + +++LTE E+ R ++ N LE EL +V
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL--RVL 1250
Query: 390 GRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRP--EVYRLINE-E 446
G+ KQE++ + L + K + AE+ +K L V ++NE E
Sbjct: 1251 GQA---KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 447 AMVMNYAL-LGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEA-----LLQ 500
+ A + + + Q L++ +Q+L+ + + L + +L+ + Q
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Query: 501 SFSEFMASESIHTPPAVTKELEVMLKTQNVLQ------QRRLKHLCTICDLLPPSYSKTQ 554
+ +++ +I + K+L+ T L+ Q+ +++L + +Y K +
Sbjct: 1368 NLERHISTLNIQLSDS-KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426
Query: 555 LTEWHSSLNSLNKELDTYHVDCMMWIRLLY-----EKTWQECLMHVQNCKKQLLDWKAFT 609
T+ N L +ELD VD +L+ ++ + + L +N + D +
Sbjct: 1427 KTK-----NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481
Query: 610 EEEA---ETLVNQFFFQMVGALQGKVE------------EDL-----------ELLDKSF 643
E EA ET + AL+ K E EDL L+KS
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541
Query: 644 ETLADQTEWQSSHLFKYFQEVVQLWEAH-QSELLVQELE--------------LEKRMEQ 688
L Q E + L + E+ +A + E+ +Q L+ EKR +
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601
Query: 689 HRQKHSLESQVQEAHLDRLL------------DQLRQQSD-----KETLAFHLEKVKDYL 731
RQ H E+++++ R L L Q+D +E L K++ +
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Query: 732 KNMK--------SRYECFHTLLTKEV----MEYPAIMLKE-LNSYSSALSQYFFVREIFE 778
K+ + SR E F T E +E + L+E L + A Q +E
Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 779 QNLAGEVIFKFRQPEAHEKPSQKRV----KKLRKKQGSKEDM-------TRSEESISSGT 827
+ LA + + + ++ + R+ ++L ++QG+ E M T+ E +S+
Sbjct: 1722 EELASSLSGR-NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 828 STARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSL 887
+T RS + E Q++E ++ L +K+ E EG+++ + + +
Sbjct: 1781 ATERSTAQKNESARQQLE----------RQNKELRSKLHEM-EGAVKSKFKSTIAALEAK 1829
Query: 888 NPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKE 946
L E+ + EK+ ++ +K+++ +E L+ E E K A++ +E G K+
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1888
Score = 50.4 bits (119), Expect = 1e-05
Identities = 129/628 (20%), Positives = 253/628 (40%), Gaps = 109/628 (17%)
Query: 362 RLFLKVEN--DTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRT---DK 416
RLF KV+ ++ +QA + K R + E+KEL++ L + ++
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 417 LKSVLKKYAEVIEKTSYLM--RPEVYRLINE------EAMVMNYALLGNRKALAQLFVNL 468
L++ + YAE E L + E+ +++E E L RK +AQ ++L
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 469 MESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQ 528
E ++E A +++ L+ + + + V + L +
Sbjct: 963 EEQLEEEE---------------AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1007
Query: 529 NVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTW 588
L + R+ L T +L LT+ + S+ EL+ +RL E
Sbjct: 1008 RKLLEERISDLTT--NLAEEEEKAKNLTKLKNKHESMISELE---------VRLKKE--- 1053
Query: 589 QECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEE-DLELLDKSFETLA 647
+ +++L K E +A F + + LQ ++ E ++L K E A
Sbjct: 1054 -------EKSRQELEKLKRKLEGDASD-----FHEQIADLQAQIAELKMQLAKKEEELQA 1101
Query: 648 -----DQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEK--RMEQHRQKHSLESQVQ 700
D Q ++ K +E+ E H S+L ++L+ E+ R + +QK L ++
Sbjct: 1102 ALARLDDEIAQKNNALKKIREL----EGHISDLQ-EDLDSERAARNKAEKQKRDLGEEL- 1155
Query: 701 EAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKEL 760
EA L D L + ++ L E+ LK H +E+ + A ++EL
Sbjct: 1156 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215
Query: 761 NSYSSALSQYFFVREIFEQN----------LAGE--VIFKFRQPEAHEKPS-QKRVKKLR 807
+ L Q+ + ++N LAGE V+ + +Q H+K + +V++L+
Sbjct: 1216 ---TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 808 KKQGSKE-----------DMTRSEESISSGTSTA--RSVEEVEEENDQEMESFITEEVLG 854
K E + ES++ + A ++++ ++ + T+E+L
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 855 QQKKSPLHAKMD----ESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKE------ 904
++ + L+ E + S+Q + ++E + +L ++ N++ KK+
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392
Query: 905 --ESEEEDEKEEEEEEEKLEEEKEEKEA 930
E+ EE +K ++E E L ++ EEK A
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAA 1420
Score = 44.3 bits (103), Expect = 0.001
Identities = 90/404 (22%), Positives = 158/404 (39%), Gaps = 81/404 (20%)
Query: 802 RVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQ---QKK 858
+VK L + +E+M E+ + + E +E +Q+ E+ L Q Q +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 859 SPLHAKMDESK---EGSIQGLEEMQVEREGSLNPSLNEENVKGQ---GEKKEESEEEDEK 912
+ L+A+ +E + Q LEE+ E E L EE +GQ E+K+ +++ +
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLE----EEEDRGQQLQAERKKMAQQMLDL 962
Query: 913 EEEEEEE-------------------KLEEE------------KEEKEAQEEQESL--SV 939
EE+ EEE KLE+E KE K +E L ++
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 940 GEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKF 999
EEE+K + L ++ ++ IS +EE R+ D S F
Sbjct: 1023 AEEEEKAKNLTKL--KNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASD--F 1074
Query: 1000 IEQVTIPSRLILEIKKQLFSEGGNFSPKEINSLCSRLEKEAARIELVESVIMLNMEKLE- 1058
EQ+ I E+K QL + +E+ + +RL+ E A+ ++ + + +LE
Sbjct: 1075 HEQIADLQAQIAELKMQLAKK-----EEELQAALARLDDEIAQ----KNNALKKIRELEG 1125
Query: 1059 -----NEYLDQANDVINKFESKFHNLSVDLIFIEKIQRLLTNLQVKIKCQV------AKS 1107
E LD NK E + +L E+++ L T L+ + AK
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLG------EELEALKTELEDTLDSTATQQELRAKR 1179
Query: 1108 NSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTWK 1151
+ L +L + + + +K EEL ++ +K
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1223
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 73.9 bits (180), Expect = 1e-12
Identities = 149/746 (19%), Positives = 305/746 (40%), Gaps = 99/746 (13%)
Query: 267 VLHREKERAKREKAR----ESENTIAAREVRGLMDTIVPEKISTSTFQRQ---AEHKRKS 319
+LH + R + E+ R ++E A+++ L + + E+ + Q + AE K K
Sbjct: 923 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982
Query: 320 YESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQ 379
E + ++ ++ KE + L L E ++ N LK ++++ + + +
Sbjct: 983 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV- 1041
Query: 380 ALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRPE- 438
RL ++ +EL++ LE +D + + A++ E L + E
Sbjct: 1042 -----------RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090
Query: 439 ----VYRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWK--- 491
+++E N AL R+ + S LQ++LDS + + K
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHI------SDLQEDLDSERAARNKAEKQKRDL 1144
Query: 492 ALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNV----------LQQRRLKHLCT 541
+ EAL + + S + +E EV + + + +Q+ R KH
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 542 ICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQ 601
+ +L + Q ++L+ + L+ + D +R+L + V++ KK+
Sbjct: 1205 VEEL---TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL-----GQAKQEVEHKKKK 1256
Query: 602 L------LDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSS 655
L L K E A +N V LQ +VE +L+++ E A + +
Sbjct: 1257 LEAQVQELQSKCSDGERARAELND----KVHKLQNEVESVTGMLNEA-EGKAIKLAKDVA 1311
Query: 656 HLFKYFQEVVQLWEAHQSELLVQELELEKRMEQ-HRQKHSLESQVQEA-----HLDRLLD 709
L Q+ +L + E Q+L + ++ Q +++SL+ Q+ E +L+R +
Sbjct: 1312 SLSSQLQDTQELLQ----EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367
Query: 710 QLR-QQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALS 768
L Q SD + + L+ K R++ LT++ E A K L + L
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK-LEKTKNRLQ 1426
Query: 769 QYF--FVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSE--ESIS 824
Q V ++ Q +++ + + K + K + D +E E +
Sbjct: 1427 QELDDLVVDLDNQR---QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 825 SGTSTARSVEEVEEENDQ----------EMESFIT-EEVLG------QQKKSPLHAKMDE 867
S AR++EE E ++ EME ++ ++ +G ++ K L +M+E
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 868 SKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKK-EESEEEDEKEEEEEEEKLEEEKE 926
K + +E+Q + L +N + +KGQ E+ + +E++E++ + + +L E +
Sbjct: 1544 MKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603
Query: 927 EKEAQEEQESLSVGEEEDKEEGLEEI 952
E E + +Q +L+ ++ E L+++
Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDL 1629
Score = 61.2 bits (147), Expect = 8e-09
Identities = 194/973 (19%), Positives = 371/973 (38%), Gaps = 161/973 (16%)
Query: 358 EEMNRLFLKVENDTNLEDYTIQALLELW---DKVAGRLLLRKQEIKELDEALHSLEF--- 411
+E+ + ++ + NL +QA EL+ +++ RL +KQE++E+ LH +E
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI---LHEMEARLE 932
Query: 412 ---SRTDKLKSVLKKYA-EVIEKTSYLMRPEVYR---------------LINEEAMVM-- 450
R +L++ KK A ++++ L E R + +E +VM
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 451 -NYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASE 509
N L RK L + +L + ++E + K L++ E M S
Sbjct: 993 QNNKLSKERKLLEERISDLTTNLAEEE--------------EKAKNLTKLKNKHESMIS- 1037
Query: 510 SIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKEL 569
ELEV LK + +Q L+ L + + + Q+ + + + L +L
Sbjct: 1038 ----------ELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHE-QIADLQAQIAELKMQL 1085
Query: 570 DTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQ 629
+ + L ++ Q+ N K++ + + + E L ++ + Q
Sbjct: 1086 AKKEEELQAALARLDDEIAQK-----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 630 GK-VEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQ 688
+ + E+LE L E D T Q K QEV L +A E E ++++ ++
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Query: 689 HRQK-HSLESQVQE-----AHLD-----------------RLLDQLRQQSD--KETLAFH 723
H Q L Q+++ A+LD R+L Q +Q+ + K+ L
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 724 LEKVK--------------DYLKNMKSRYECFHTLLTKEVMEYPAIML-KELNSYSSALS 768
+++++ D + +++ E +L + E AI L K++ S SS L
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGKAIKLAKDVASLSSQLQ 1318
Query: 769 Q-YFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRV-KKLRKKQGSKE-------DMTRS 819
++E Q L V K RQ E Q ++ +++ KQ + ++ S
Sbjct: 1319 DTQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 820 EESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEM 879
++ + ST ++EE ++ +E+E+ + ++K+ + K++++K Q L+++
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQ----YEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 880 QVEREGSLNPSLNEENVKGQ------GEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEE 933
V+ + N E + + EK S+ DE++ E E + +E K A+
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492
Query: 934 QESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFIND 993
+E+L EE ++ + + ED+ S G E E +++ T
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH-----ELEKSKRALETQMEEMKTQ 1547
Query: 994 TSSAKFIEQVTIPSRLILEIKKQLF-----------SEGGNFSPKEINSLCSRLEKEAAR 1042
+ Q T ++L LE+ Q E +++ E E
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 1043 IELVESVIMLNMEKLENEYLD---QANDVINKFESKFHNLSVDLIFIEKIQRLLTNLQV- 1098
++ +KLE + D QA+ I E L ++ QR L + +
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1667
Query: 1099 --KIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGE---KTTVTTEELLS------FV 1147
+I ++ + L L QLQ + + +R + + EEL S +
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1727
Query: 1148 QTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEAKLDVVTP 1207
Q K +L RI L L+ ++ + K ++ + S L E
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL---SNELATERSTAQKNE 1784
Query: 1208 ESFTQLSRVGKPL 1220
+ QL R K L
Sbjct: 1785 SARQQLERQNKEL 1797
Score = 52.4 bits (124), Expect = 4e-06
Identities = 148/717 (20%), Positives = 275/717 (38%), Gaps = 95/717 (13%)
Query: 242 EGEVMSPRQQKWMHSLPNDWIMENPVLHREKERAKREKARESENTIAAREVRGLMDTIVP 301
+GE +H L N+ +L+ + +A + + + ++ + L+
Sbjct: 1270 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 302 EKISTSTFQRQAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGLFLK-----KLTES 356
+K++ ST RQ E +R S + L E + + + L + K E+
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 357 DEEMNRLFLK-VENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSR-- 413
EE + F K +EN T + A +L +K RL +ELD+ + L+ R
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKL-EKTKNRLQ------QELDDLVVDLDNQRQL 1442
Query: 414 TDKLKSVLKKYAEVIEKTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQLFVNLMESTL 473
L+ +K+ +++ + + + +E A KAL+ + L
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISS----KYADERDRAEAEAREKETKALS------LARAL 1492
Query: 474 QQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQ 533
++ L+++ L T K LK E S+ +++H + LE ++
Sbjct: 1493 EEALEAKEE---LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM----- 1544
Query: 534 RRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLM 593
KTQL E L + V+ M ++ +E+ Q
Sbjct: 1545 ------------------KTQLEELEDELQATEDAKLRLEVN-MQALKGQFERDLQA--R 1583
Query: 594 HVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQ 653
QN +K+ + E E E + + A + K+E DL+ L+ ++ E
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1643
Query: 654 SSHL------FKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLD-R 706
L K FQ ++ A + E+ E EK+ + SLE+ + + D
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK------SLEADLMQLQEDLA 1697
Query: 707 LLDQLRQQSD--KETLAFHLEKV---KDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELN 761
++ R+Q+D KE LA L ++ L++ K R E L +E+ E M +
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
Query: 762 SYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEE 821
A Q E LA E + A ++ +++ K+LR K E +S+
Sbjct: 1758 RVRKATQQ----AEQLSNELATERSTAQKNESARQQ-LERQNKELRSKLHEMEGAVKSKF 1812
Query: 822 SISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEE--M 879
+ A+ + ++EE+ +QE ++K++ + + K+ L+E +
Sbjct: 1813 KSTIAALEAK-IAQLEEQVEQE----------AREKQAATKSLKQKDKK-----LKEILL 1856
Query: 880 QVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQES 936
QVE E + E+ KG K+ + +E EEE + K ++E E ES
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Score = 51.6 bits (122), Expect = 6e-06
Identities = 156/779 (20%), Positives = 307/779 (39%), Gaps = 128/779 (16%)
Query: 271 EKERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALASFQEE 330
+ ERA R KA + + + E + T + + + ++ Q++ KR+ + L +E
Sbjct: 1128 DSERAARNKAEKQKRDLG--EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 331 IAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVE-NDTNLEDYTIQALLELWDKVA 389
+ + + +++LTE E+ R ++ N LE EL +V
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL--RVL 1243
Query: 390 GRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRP--EVYRLINE-E 446
G+ KQE++ + L + K + AE+ +K L V ++NE E
Sbjct: 1244 GQA---KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 447 AMVMNYAL-LGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEA-----LLQ 500
+ A + + + Q L++ +Q+L+ + + L + +L+ + Q
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360
Query: 501 SFSEFMASESIHTPPAVTKELEVMLKTQNVLQ------QRRLKHLCTICDLLPPSYSKTQ 554
+ +++ +I + K+L+ T L+ Q+ +++L + +Y K +
Sbjct: 1361 NLERHISTLNIQLSDS-KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419
Query: 555 LTEWHSSLNSLNKELDTYHVDCMMWIRLLY-----EKTWQECLMHVQNCKKQLLDWKAFT 609
T+ N L +ELD VD +L+ ++ + + L +N + D +
Sbjct: 1420 KTK-----NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474
Query: 610 EEEA---ETLVNQFFFQMVGALQGKVE------------EDL-----------ELLDKSF 643
E EA ET + AL+ K E EDL L+KS
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534
Query: 644 ETLADQTEWQSSHLFKYFQEVVQLWEAH-QSELLVQELE--------------LEKRMEQ 688
L Q E + L + E+ +A + E+ +Q L+ EKR +
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594
Query: 689 HRQKHSLESQVQEAHLDRLL------------DQLRQQSD-----KETLAFHLEKVKDYL 731
RQ H E+++++ R L L Q+D +E L K++ +
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Query: 732 KNMK--------SRYECFHTLLTKEV----MEYPAIMLKE-LNSYSSALSQYFFVREIFE 778
K+ + SR E F T E +E + L+E L + A Q +E
Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 779 QNLAGEVIFKFRQPEAHEKPSQKRV----KKLRKKQGSKEDM-------TRSEESISSGT 827
+ LA + + + ++ + R+ ++L ++QG+ E M T+ E +S+
Sbjct: 1715 EELASSLSGR-NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 828 STARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSL 887
+T RS + E Q++E ++ L +K+ E EG+++ + + +
Sbjct: 1774 ATERSTAQKNESARQQLE----------RQNKELRSKLHEM-EGAVKSKFKSTIAALEAK 1822
Query: 888 NPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKE 946
L E+ + EK+ ++ +K+++ +E L+ E E K A++ +E G K+
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1881
Score = 50.4 bits (119), Expect = 1e-05
Identities = 129/628 (20%), Positives = 253/628 (40%), Gaps = 109/628 (17%)
Query: 362 RLFLKVEN--DTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRT---DK 416
RLF KV+ ++ +QA + K R + E+KEL++ L + ++
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 417 LKSVLKKYAEVIEKTSYLM--RPEVYRLINE------EAMVMNYALLGNRKALAQLFVNL 468
L++ + YAE E L + E+ +++E E L RK +AQ ++L
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 469 MESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQ 528
E ++E A +++ L+ + + + V + L +
Sbjct: 956 EEQLEEEE---------------AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1000
Query: 529 NVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTW 588
L + R+ L T +L LT+ + S+ EL+ +RL E
Sbjct: 1001 RKLLEERISDLTT--NLAEEEEKAKNLTKLKNKHESMISELE---------VRLKKE--- 1046
Query: 589 QECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEE-DLELLDKSFETLA 647
+ +++L K E +A F + + LQ ++ E ++L K E A
Sbjct: 1047 -------EKSRQELEKLKRKLEGDASD-----FHEQIADLQAQIAELKMQLAKKEEELQA 1094
Query: 648 -----DQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEK--RMEQHRQKHSLESQVQ 700
D Q ++ K +E+ E H S+L ++L+ E+ R + +QK L ++
Sbjct: 1095 ALARLDDEIAQKNNALKKIREL----EGHISDLQ-EDLDSERAARNKAEKQKRDLGEEL- 1148
Query: 701 EAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKEL 760
EA L D L + ++ L E+ LK H +E+ + A ++EL
Sbjct: 1149 EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208
Query: 761 NSYSSALSQYFFVREIFEQN----------LAGE--VIFKFRQPEAHEKPS-QKRVKKLR 807
+ L Q+ + ++N LAGE V+ + +Q H+K + +V++L+
Sbjct: 1209 ---TEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 808 KKQGSKE-----------DMTRSEESISSGTSTA--RSVEEVEEENDQEMESFITEEVLG 854
K E + ES++ + A ++++ ++ + T+E+L
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 855 QQKKSPLHAKMD----ESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKE------ 904
++ + L+ E + S+Q + ++E + +L ++ N++ KK+
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385
Query: 905 --ESEEEDEKEEEEEEEKLEEEKEEKEA 930
E+ EE +K ++E E L ++ EEK A
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAA 1413
Score = 44.3 bits (103), Expect = 0.001
Identities = 90/404 (22%), Positives = 158/404 (39%), Gaps = 81/404 (20%)
Query: 802 RVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQ---QKK 858
+VK L + +E+M E+ + + E +E +Q+ E+ L Q Q +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899
Query: 859 SPLHAKMDESK---EGSIQGLEEMQVEREGSLNPSLNEENVKGQ---GEKKEESEEEDEK 912
+ L+A+ +E + Q LEE+ E E L EE +GQ E+K+ +++ +
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLE----EEEDRGQQLQAERKKMAQQMLDL 955
Query: 913 EEEEEEE-------------------KLEEE------------KEEKEAQEEQESL--SV 939
EE+ EEE KLE+E KE K +E L ++
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 940 GEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKF 999
EEE+K + L ++ ++ IS +EE R+ D S F
Sbjct: 1016 AEEEEKAKNLTKL--KNKHESMISELEVRL----KKEEKSRQELEKLKRKLEGDASD--F 1067
Query: 1000 IEQVTIPSRLILEIKKQLFSEGGNFSPKEINSLCSRLEKEAARIELVESVIMLNMEKLE- 1058
EQ+ I E+K QL + +E+ + +RL+ E A+ ++ + + +LE
Sbjct: 1068 HEQIADLQAQIAELKMQLAKK-----EEELQAALARLDDEIAQ----KNNALKKIRELEG 1118
Query: 1059 -----NEYLDQANDVINKFESKFHNLSVDLIFIEKIQRLLTNLQVKIKCQV------AKS 1107
E LD NK E + +L E+++ L T L+ + AK
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLG------EELEALKTELEDTLDSTATQQELRAKR 1172
Query: 1108 NSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTWK 1151
+ L +L + + + +K EEL ++ +K
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1216
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 72.4 bits (176), Expect = 3e-12
Identities = 109/457 (23%), Positives = 199/457 (43%), Gaps = 79/457 (17%)
Query: 559 HSSLNSLNKELDTYHVDCMMWIRLLY-EKT-WQECLMHVQNCKKQLLDWKAFTEEEAETL 616
H +L +EL+ + IR+L +KT Q L + Q+ KQL E EA L
Sbjct: 103 HQHQEALRRELEAQ----VQTIRILTCQKTELQMALYYSQHAVKQL-------EGEARDL 151
Query: 617 VNQFF--FQMVGALQ---GKVEEDLELLDKSFETLADQTEWQSSHLFKY----------- 660
+++ ++ G L+ V + D+ E L + + S L++
Sbjct: 152 ISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKN 211
Query: 661 --FQEVVQLWEAHQSELLVQELELEKRMEQ---------------HRQKH------SLES 697
QE +QL E+ +SE+ + EL++++E+ H K L++
Sbjct: 212 AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA 271
Query: 698 QVQEAHLDRLLDQLRQ----------QSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTK 747
QV+E L L+Q ++ Q +E + EK+++ + M+ + E K
Sbjct: 272 QVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEK 331
Query: 748 EVMEYPAIMLKE--LNSYSSALSQYFFVREIFEQNLAGEVIF---KFRQPEAHEKPSQKR 802
+ + KE + + + +RE E+ E I K ++ EA +++
Sbjct: 332 MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 391
Query: 803 VKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKS--P 860
+++ +K +E+M + +E G + E+ EE +QE + EE + +Q+K
Sbjct: 392 IREQEEKIREQEEMMQEQEE-KMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIRE 450
Query: 861 LHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEE---EDEKEEEEE 917
K+ E +E +Q EE E+EG + E ++ Q EK EE E EK+ E+
Sbjct: 451 QEEKIREQEE-MMQEQEEKMGEQEGKM--CEQEAKMQEQEEKMRRQEEKIREQEKKIREQ 507
Query: 918 EEKLEEEKEEKEAQEE---QESLSVGEEEDKEEGLEE 951
EEK+ E++E + QEE ++ + E+E+K + EE
Sbjct: 508 EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 544
Score = 68.2 bits (165), Expect = 6e-11
Identities = 78/351 (22%), Positives = 154/351 (43%), Gaps = 73/351 (20%)
Query: 605 WKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTE--WQSSHLFKYFQ 662
W +++ E + Q + + + K++E E + + E + Q E W+ + +
Sbjct: 279 WNRLNQQQEEKMWRQE--EKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQE 336
Query: 663 EVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAF 722
E+ +WE + ++ELE EK EQ + + E + +E +++ +Q ++Q + +
Sbjct: 337 EM--MWEKEEK---IRELE-EKMHEQEKIREQEEKRQEE---EKIREQEKRQEQEAKMWR 387
Query: 723 HLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLA 782
EK+++ + ++ + E M++E
Sbjct: 388 QEEKIREQEEKIREQEE----------------MMQE----------------------- 408
Query: 783 GEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQ 842
Q E + +K ++ + Q +E M R EE I R EE E ++
Sbjct: 409 --------QEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 460
Query: 843 EMESFITEEVLGQQ--KKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQG 900
M+ EE +G+Q K AKM E +E ++ EE E+E + EE ++ Q
Sbjct: 461 MMQE--QEEKMGEQEGKMCEQEAKMQEQEE-KMRRQEEKIREQEKKIREQ--EEKIREQE 515
Query: 901 EKKEESEEEDEKEEE---EEEEKLEEEKEEKEAQEE---QESLSVGEEEDK 945
E +E EE+ ++EE E+EEK++E++E+ QEE ++ + + ++E+K
Sbjct: 516 EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566
Score = 63.9 bits (154), Expect = 1e-09
Identities = 61/249 (24%), Positives = 111/249 (44%), Gaps = 20/249 (8%)
Query: 731 LKNMKSRYECFHTLLTKEVMEYPAIML-KELNSYSSALSQYFFVREIFEQNLAGEVIFKF 789
+K +K + E LL ++ ++ A L KEL S S+ L E++ + + +
Sbjct: 232 VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMW 291
Query: 790 RQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFIT 849
RQ E ++ +K ++ K + +E M R EE + R EE+ E ++++
Sbjct: 292 RQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL-- 349
Query: 850 EEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEE- 908
EE + +Q+K + E K + + E + +E EE ++ Q EK E EE
Sbjct: 350 EEKMHEQEK----IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEM 405
Query: 909 ----------EDEK--EEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYED 956
++EK E+EEE ++ EE+ +E + ++ + E+E+K EE+ E
Sbjct: 406 MQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ 465
Query: 957 MESFTISSG 965
E G
Sbjct: 466 EEKMGEQEG 474
Score = 58.9 bits (141), Expect = 4e-08
Identities = 83/339 (24%), Positives = 145/339 (42%), Gaps = 42/339 (12%)
Query: 629 QGKVEEDLELLDKSFETLADQ-TEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRME 687
Q + +LE ++ L Q TE Q + Y Q V+ E +L+ + + K
Sbjct: 106 QEALRRELEAQVQTIRILTCQKTELQMA--LYYSQHAVKQLEGEARDLISRLHDSWKFAG 163
Query: 688 QHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDY-LKNMKSRYECFHTLLT 746
+ Q S + Q+ DR +++L ++ D +L + + D LK ++ + L+
Sbjct: 164 ELEQALSAVA-TQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVE 222
Query: 747 KEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKL 806
E E + +KEL + +Q L E ++ ++ Q +V++
Sbjct: 223 SEKSEIQ-LNVKELKRKLERAKLL-----LPQQQLQAEADHLGKELQSVSAKLQAQVEEN 276
Query: 807 ----RKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLH 862
R Q +E M R EE I EE QE E I E Q++K
Sbjct: 277 ELWNRLNQQQEEKMWRQEEKIQE-----------REEKIQEQEEKIRE----QEEKMRRQ 321
Query: 863 AKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESE---EEDEKEEEEEEE 919
+M KE ++ EEM E+E E ++ EK E E E++EK +EEE+
Sbjct: 322 EEMMWEKEEKMRRQEEMMWEKE---------EKIRELEEKMHEQEKIREQEEKRQEEEKI 372
Query: 920 KLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDME 958
+ +E+++E+EA+ ++ + E+E+K EE+ E E
Sbjct: 373 REQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEE 411
Score = 36.6 bits (83), Expect = 0.21
Identities = 84/423 (19%), Positives = 160/423 (37%), Gaps = 57/423 (13%)
Query: 1091 RLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTW 1150
R+LT + +++ + S L + L +++ + GE E+ LS V T
Sbjct: 121 RILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGE-----LEQALSAVATQ 175
Query: 1151 KEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEAKLDVVTPESF 1210
K+K + I+ L D +S+ ++ NTI D ++ + L+E+ +L V + +S
Sbjct: 176 KKKADRYIEELTKERDALSLE--LYRNTIT-----DEELKEKNAKLQEKLQL-VESEKSE 227
Query: 1211 TQLSRVGKPLIEDPAVDVIRKLLQLPNTKWPTH--HCDKDPSQTGFKRHRCQPENSGKKA 1268
QL+ +++ + R L LP + H K+ K EN
Sbjct: 228 IQLN------VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 281
Query: 1269 VPSASATSAG----SLQTTHPPLSHSFTP-HPKPNKMERKYRVLGDKPPPAAEDFKGIIL 1323
+ +Q + + KM R+ ++ +K +
Sbjct: 282 LNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE---- 337
Query: 1324 TLLWESSENLLTVAEEFYRKEKRPVTRPDCMCDTFDQCAENISKKILEYQSQANKYHNSC 1383
++WE E + + E+ + +EK Q E I ++ + +A +
Sbjct: 338 -MMWEKEEKIRELEEKMHEQEKIREQEEK------RQEEEKIREQEKRQEQEAKMWRQEE 390
Query: 1384 LI-ELRIQIRRFEELLPQV----------CWLVMENFKEHHWK------KFFTSVKEIRG 1426
I E +IR EE++ + W E +E K K K+IR
Sbjct: 391 KIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIRE 450
Query: 1427 QFE---EQQKRLEKRKDKNAQKLHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEK 1483
Q E EQ++ ++++++K ++ QE E +EE+ E + IR +EK
Sbjct: 451 QEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEK 510
Query: 1484 LEE 1486
+ E
Sbjct: 511 IRE 513
Score = 33.5 bits (75), Expect = 1.7
Identities = 27/161 (16%), Positives = 72/161 (44%), Gaps = 11/161 (6%)
Query: 1326 LWESSENLLTVAEEFYRKEKRPVTRPDCMCDTFDQCAENISKKILEYQSQANKYHNSCLI 1385
+WE E + E+ R+E++ + + + ++ E +++++ Q + +
Sbjct: 420 MWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ--EEMMQEQEEKMGEQEGKMC 477
Query: 1386 ELRIQIRRFEELLPQVCWLVMENFKEHHWKKFFTSVKEIRGQFEEQQKRLEKRKDKNAQK 1445
E +++ EE + + + E K+ ++E + EQ++ ++++++K ++
Sbjct: 478 EQEAKMQEQEEKMRRQEEKIREQEKK---------IREQEEKIREQEEMMQEQEEKMWEQ 528
Query: 1446 LHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEKLEE 1486
QE E +EE+ E + +R +EK++E
Sbjct: 529 EEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 33.1 bits (74), Expect = 2.3
Identities = 63/328 (19%), Positives = 133/328 (40%), Gaps = 46/328 (14%)
Query: 151 VQSSSEELELRHQSLDAFPGRR---LPGRGIQPAAKMSSVGKVTQVPNGKAYQQIFQAEV 207
V+S E++L + L R LP + +Q A+ +GK Q + K Q+ + E+
Sbjct: 221 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQ--AEADHLGKELQSVSAKLQAQVEENEL 278
Query: 208 ------QLVHSLAATRKRAAERSVTLKSGRIPMMKKVETP--EGEVMSPRQQKWMHSLPN 259
Q + ++ ER ++ + ++ E + E+M +++K
Sbjct: 279 WNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM 338
Query: 260 DWIMENPVLHREKERAKREKARE------SENTIAAREVRGLMDTIV---PEKISTSTFQ 310
W E + E++ ++EK RE E I +E R + + EKI
Sbjct: 339 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI------ 392
Query: 311 RQAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKV--- 367
R+ E K + E + QE+ ++G++ E + +++ E +E+M R K+
Sbjct: 393 REQEEKIREQEEMM---QEQEEKMGEQEEKMWEQE-----EEMQEQEEKMRRQEEKIREQ 444
Query: 368 -------ENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSV 420
E ++ +Q E + G++ ++ +++E +E + E ++ K +
Sbjct: 445 EKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKI 504
Query: 421 LKKYAEVIEKTSYLMRPEVYRLINEEAM 448
++ ++ E+ + E EE M
Sbjct: 505 REQEEKIREQEEMMQEQEEKMWEQEEKM 532
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 71.2 bits (173), Expect = 8e-12
Identities = 214/1044 (20%), Positives = 424/1044 (40%), Gaps = 173/1044 (16%)
Query: 273 ERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALASFQEEIA 332
+ A +EK + E +A R++ + +++ R ++ + + ++
Sbjct: 354 QEALKEKQQHIEQLLAERDLERA--EVAKATSHVGEIEQELALARDGHDQHVLELEAKMD 411
Query: 333 QVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQALLELWDKVAGRL 392
Q+ +E + L L +L E ++ L +VE E+ + LE K
Sbjct: 412 QLRTMVEAADREKVEL-LNQLEEEKRKVEDLQFRVE-----EESITKGDLETQTK----- 460
Query: 393 LLRKQEIKELDEALHSLEFSRTDKLKSVLK--KYAEVIEKTSYLMRPEVYRLINEEAMVM 450
L IKEL+++L E ++ DKL+ L+ + A V EK+ + + L +E +
Sbjct: 461 -LEHARIKELEQSL-LFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAEL 518
Query: 451 NYALLGNRKAL-AQLFVNLME--STLQQELD-SRHRWQGLVDTWKALKKEALLQSFSEFM 506
L N+ A + ++L++ S+LQ++L+ +R Q + + K F
Sbjct: 519 RRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLK-----------EHFG 567
Query: 507 ASESIHTPPAVTKELEVM------LKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHS 560
A E H KE++ + L +N + +L+H + + W S
Sbjct: 568 AREETHQ-----KEIKALYTATEKLSKENESLKSKLEHA--------NKENSDVIALWKS 614
Query: 561 SLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQF 620
L + H M +++ + K K Q+ + + E E L NQ
Sbjct: 615 KLETAIAS----HQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQ 670
Query: 621 FFQMVG------ALQGKVEEDLELLDKSFETLADQTEW-QSSHLFKYFQEVVQLWEAHQS 673
+ AL+ K+ + ++ + S E + + + + HL + + +L EA
Sbjct: 671 DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA--- 727
Query: 674 ELLVQELEL--EKRMEQHRQKHSLESQVQEAHLDRL-LDQLRQ-----QSDKETLAFHLE 725
E+ V+ELE+ K EQ + + SQ++ L LD LR+ +S+ + L LE
Sbjct: 728 EIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE 787
Query: 726 KVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEV 785
+ +K+++ + + E LK L + LS+ V+E E+ L
Sbjct: 788 AAEKQIKHLEIEKNAESSKASSITRELQGRELK-LTNLQENLSEVSQVKETLEKELQ--- 843
Query: 786 IFKFRQPEAHE------KPSQKRVKKLRKKQGS----KEDMTRSEESISSGTSTARSVEE 835
I K + EA E + Q+ V KL +K+ D+ + E+++ + R +E
Sbjct: 844 ILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDE 903
Query: 836 VEEE---NDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVE-REGSLNPSL 891
EE+ +++E+ I E + S KM++ + +EE+Q++ + + N S
Sbjct: 904 REEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASF 963
Query: 892 NEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEE-----------------Q 934
+++++ K E+S++E K+ EEE+++LE + + E + E
Sbjct: 964 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATS 1023
Query: 935 ESLSVGEE------------EDKEEG--------LEEIYYEDMESFTISSGNTYFVFVPL 974
E+ + EE EDK +G L+E+ ++ + T + +
Sbjct: 1024 ETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQI 1083
Query: 975 EEEHCRKSHSTFSAMFINDTSSAKF------IEQVTIPSRLILEIKKQLFSEGGNFSPKE 1028
E+ ++ T +++ ++AK +++ + + L K+L + N +E
Sbjct: 1084 MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTV-ENQKMEE 1142
Query: 1029 INSLCSRLEKEAARIELVESVIMLNMEKLENEYLDQANDVI---NKFESKFHNLSVDLIF 1085
L++ AA+ S + KL E L ++ D + K E + L+ L+
Sbjct: 1143 FRKEIETLKQAAAQKSQQLSALQEENVKLAEE-LGRSRDEVTSHQKLEEERSVLNNQLLE 1201
Query: 1086 IEKIQRLLTNLQVKIKCQVAKSNSQTNGL----NFSLQQLQNKIKTCQESRGEKTTVTTE 1141
++K + + K + KS S T+ L + L++L+N++ RGE + +
Sbjct: 1202 MKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVL---RGE--NASAK 1256
Query: 1142 ELLSFVQTW---KEKLSQRIQYLNCSL---------------------DRVSMTELVFTN 1177
L S VQT K KL +++ L L +R +++ F N
Sbjct: 1257 SLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLN 1316
Query: 1178 TILKD-QEEDSDILTSSEALEEEA 1200
+++ D Q ++ D+ E + E A
Sbjct: 1317 SVIVDLQRKNQDLKMKVEMMSEAA 1340
Score = 52.0 bits (123), Expect = 5e-06
Identities = 178/950 (18%), Positives = 357/950 (37%), Gaps = 152/950 (16%)
Query: 589 QECLMHVQNCKKQLL---DWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDK--SF 643
QE L Q +QLL D + +A + V + ++ A G + LEL K
Sbjct: 354 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
Query: 644 ETLADQTEWQSSHLFKYFQEVVQLWE-----AHQSELLVQELELEKRMEQHRQKH----- 693
T+ + + + L +E + E + + +LE + ++E R K
Sbjct: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSL 473
Query: 694 --------SLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLL 745
L+ ++++ + + ++ R ++ LA +++V + + ++S
Sbjct: 474 LFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGD--- 530
Query: 746 TKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKK 805
++ +L+E++S L E+ + E+ A E+ QK +K
Sbjct: 531 ----VDMSLSLLQEISSLQEKL-------EVTRTDHQREITSLKEHFGAREETHQKEIKA 579
Query: 806 LRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKM 865
L + E +++ ES+ S +E +EN +V+ K +K+
Sbjct: 580 LYT---ATEKLSKENESLKS------KLEHANKENS---------DVIALWK-----SKL 616
Query: 866 DESKEGSIQGLEEMQVEREGSLNPSLNE-ENVKGQGEKKE-ESEEEDEKEEEEEEEKLEE 923
+ + Q +EE++V L E +K Q EK + + E E + +++ +
Sbjct: 617 ETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAA 676
Query: 924 EKEEKEAQEEQESLSVGEEEDKEEGL-------EEIYYEDMESFTISSGNTYFVFVPLEE 976
+E EA + + E+E+ E + E+ + +ME LE
Sbjct: 677 HAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV 736
Query: 977 EHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRLILEIKKQLFSEGGNFSPKEINSLCSRL 1036
+ + T + N TS K E+ L L+ ++ SEG + K++
Sbjct: 737 LQAKCNEQT--KVIDNFTSQLKATEE----KLLDLDALRKASSEGKS-EMKKLRQQLEAA 789
Query: 1037 EKEAARIELVESVIMLNMEKLENEYLDQANDVINKFESKFHNLSVDLIFIEKIQRLLTNL 1096
EK+ +E+ ++ + E + E K NL +L + +++ L
Sbjct: 790 EKQIKHLEIEKNAESSKASSITRELQGR--------ELKLTNLQENLSEVSQVKETLEKE 841
Query: 1097 QVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTWKEKLSQ 1156
+K + A+++ + + S+Q+ NK+ EE + + + EKL +
Sbjct: 842 LQILKEKFAEASEEAVSVQRSMQETVNKLHQ------------KEEQFNMLSSDLEKLRE 889
Query: 1157 RIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEE-AKLDVVTPESFTQLSR 1215
+ + KD+ E+ ++ + E LE + A++ ++ ++ +QL++
Sbjct: 890 NLADMEAKFRE-------------KDEREEQ-LIKAKEKLENDIAEIMKMSGDNSSQLTK 935
Query: 1216 VGKPL-IEDPAVDVIRKLLQLPNTKWPTHHCDKDPSQTGFKRHRCQPENSGKKAVPSASA 1274
+ L +++ V+ ++ L+L K K + Q E + K
Sbjct: 936 MNDELRLKERDVEELQ--LKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE- 992
Query: 1275 TSAGSLQTTHPPLSHSF-TPHPKPNKMERKY-RVLGDKPPPAAEDFKGIILTLL------ 1326
L+ L T H + +++ +Y R + E + + TLL
Sbjct: 993 -----LERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKL 1047
Query: 1327 ---WESSENLLTVAEEFYR---KEKRPVTRPDCMCDTFDQCAENISKK------ILEYQS 1374
E + LL EE + K K T D M Q E ++K+ LE
Sbjct: 1048 KGAREENSGLLQELEELRKQADKAKAAQTAEDAM-----QIMEQMTKEKTETLASLEDTK 1102
Query: 1375 QAN-KYHNSCLIELRIQIRRFEELLPQVCWLVMENFKEHHWKKFFTSVKEIRGQFEEQQK 1433
Q N K N ++ EEL L +EN K ++K ++K+ Q +Q
Sbjct: 1103 QTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLS 1162
Query: 1434 RLEKRKDKNAQKLHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEK 1483
L++ K A++L + Q++ EEER + ++ M K +
Sbjct: 1163 ALQEENVKLAEELGRSRDEVTSHQKL------EEERSVLNNQLLEMKKRE 1206
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 70.5 bits (171), Expect = 1e-11
Identities = 83/389 (21%), Positives = 167/389 (42%), Gaps = 30/389 (7%)
Query: 575 DCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEE 634
D + ++R +E+ + L +Q ++ K + + + T + + Q+ + +
Sbjct: 229 DEVAFLRSNHEEEVADLLAQIQ-ASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQ 287
Query: 635 DLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQEL------ELEKRMEQ 688
E + L + E + +E+ + QS+ + E LE+++
Sbjct: 288 AEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSD 347
Query: 689 HRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKE 748
++H+ + + + +L ++LR K +A HL + +D L N+K + E
Sbjct: 348 IEERHNHDLSSYQDTIQQLENELR--GTKWEMARHLREYQDLL-NVKMALDI-------E 397
Query: 749 VMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHE---KPSQKRVKK 805
+ Y ++ E +S+ ++ + K ++P+ K K V++
Sbjct: 398 IAAYRKLLEGEETRFSTFAGS--ITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEE 455
Query: 806 LRKKQGSKEDMTRSEESISSGT-----STARSVEEVEEENDQEMESFITEEVLGQQKKSP 860
+ ++ +++ + EE++++ T S +E EE ++E E+ EE KKSP
Sbjct: 456 IIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEA---EEEEVAAKKSP 512
Query: 861 LHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEK 920
+ A E KE + EE E E + + + G +KE S E++E E+EE E +
Sbjct: 513 VKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETE 572
Query: 921 LEEEKEEKEAQEEQESLSVGEEEDKEEGL 949
E E EE EA+EE++ EE +E L
Sbjct: 573 AEAEGEEAEAKEEKKVEEKSEEVATKEEL 601
Score = 52.4 bits (124), Expect = 4e-06
Identities = 117/600 (19%), Positives = 245/600 (40%), Gaps = 128/600 (21%)
Query: 415 DKLKSVLKKYAEVIEKTSYL------MRPEVYRLINEEAMVMNYALLGNR-----KALAQ 463
++L+ + ++A IEK YL + E+ L ++A ++A LG+ + L
Sbjct: 103 EQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQA---SHAQLGDAYDQEIRELRA 159
Query: 464 LFVNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMAS---ESIHTPPAVTKE 520
+ Q +LDS H + + + ++EA L+ +E + I V E
Sbjct: 160 TLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVE 219
Query: 521 LEVMLKT-QNVLQQRRLKHLCTICDLLPP-----------SYSKTQLTEWHSSLNSLNKE 568
L+ +++ Q+ + R H + DLL Y KT ++ ++L + +
Sbjct: 220 LDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDIS---TALKEIRSQ 276
Query: 569 LDTYHVDCMM-----WIRLLYEKTWQECLMH---VQNCKKQLLDWKAFTEEEAETL---- 616
L++ H D M W + Y K + + +++ K+++ +++ + ++ L
Sbjct: 277 LES-HSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVR 335
Query: 617 -VNQFFFQMVGALQGKVEEDLELLDKSFETLADQ---TEWQSSHLFKYFQEVVQLWEAHQ 672
+ + + ++ + DL + + L ++ T+W+ + + +Q+++ + A
Sbjct: 336 GTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALD 395
Query: 673 SELLVQELELEKR--------------MEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKE 718
E+ LE + HR ++ S++Q+ ++ +++ + +E
Sbjct: 396 IEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEE 455
Query: 719 TLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFE 778
+ E+ K +++ KS E T +T+E+ A+ +KE E
Sbjct: 456 II----EETK--VEDEKSEMEEALTAITEEL----AVSMKE------------------E 487
Query: 779 QNLAGEVIFKFRQPEAHEK-------PSQKRVKKLRKKQGSKEDMTRSEESISSGTSTAR 831
+ A E K +PEA E+ P + ++++++G KE+ EE
Sbjct: 488 KKEAAEE--KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEE---------- 535
Query: 832 SVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSL 891
EEE D+ +S EE G +K+ + E +EG E + E EG
Sbjct: 536 -----EEEEDEGAKSDQAEEG-GSEKEGSSEKEEGEQEEG------ETEAEAEGE----- 578
Query: 892 NEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEE 951
E K + + +E+SEE KEE + K+E+ ++ K + G+ + +EE
Sbjct: 579 -EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 637
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 70.5 bits (171), Expect = 1e-11
Identities = 64/198 (32%), Positives = 89/198 (44%), Gaps = 24/198 (12%)
Query: 778 EQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQ------------GSKEDMTRSEESISS 825
E+ LA + +K R E E+ +++ + + Q G +E+ R EE
Sbjct: 693 EKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKE 752
Query: 826 GTSTARSV-EEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVE-- 882
G EEVE E ++E EE G+++K E +E +G E + E
Sbjct: 753 GEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGG 812
Query: 883 -------REGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEE-Q 934
EG EE +G+ E+ E EEE E EEEE E K EEE EE E +EE +
Sbjct: 813 EVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGE 872
Query: 935 ESLSVGEEEDKE-EGLEE 951
E GEEE+ E EG EE
Sbjct: 873 EGEGEGEEEEGEGEGEEE 890
Score = 64.3 bits (155), Expect = 9e-10
Identities = 64/193 (33%), Positives = 89/193 (46%), Gaps = 26/193 (13%)
Query: 783 GEVIFKFRQPEAHEKPSQKRVKKLRKKQ-------GSKEDMT-RSEESISSGTSTARSVE 834
GE + R+ E E+ ++R K K + G +E+ R EE G VE
Sbjct: 761 GEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVE 820
Query: 835 EVEEENDQEMESFITEEVLGQQKKSPLHAKMDESK----------EGSIQGLEEMQVERE 884
E + E ++E E EE G+ ++ + +E + EG +G EE + E E
Sbjct: 821 EGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEG-EEGEGEGE 879
Query: 885 GSLNPSLNEENVKGQGEKKE-----ESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSV 939
EE +G+GE++E E E E E EEEE E K EEE EE E + E+E
Sbjct: 880 EEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEE-GE 938
Query: 940 GEEEDKE-EGLEE 951
GE ED E EG EE
Sbjct: 939 GEGEDGEGEGEEE 951
Score = 60.1 bits (144), Expect = 2e-08
Identities = 38/118 (32%), Positives = 64/118 (54%), Gaps = 1/118 (0%)
Query: 834 EEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNE 893
EE E E ++ EE G+ ++ + +E EG +G E + E EG + +
Sbjct: 968 EEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEG 1027
Query: 894 ENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEE 951
E +G+GE++E EE +E+E+E E E+ +EE+E +EE + GEEE++ + EE
Sbjct: 1028 EEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEE-EEEGKYQETGEEENERQDGEE 1084
Score = 56.6 bits (135), Expect = 2e-07
Identities = 66/227 (29%), Positives = 101/227 (44%), Gaps = 24/227 (10%)
Query: 813 KEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGS 872
+E E+ G E EEE + E E EE G+ ++ E +EG
Sbjct: 935 EEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGE----EEGEGEGEEGEGEG---EEEEGE 987
Query: 873 IQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEE-----EEEKLEEEKEE 927
+G EE + E EG EE +G+GE++EE E E E E EE EEE+ EEE EE
Sbjct: 988 GEG-EEEEGEEEGE-EEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEE 1045
Query: 928 KEAQ-EEQESLSVGEEEDKEEG-LEEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHST 985
+E + E +E+ EEE++EEG +E E+ E G Y ++ H T
Sbjct: 1046 REKEGEGEENRRNREEEEEEEGKYQETGEEENER---QDGEEYKKVSKIKGSVKYGKHKT 1102
Query: 986 FSAMFINDTSSAKFIEQVTIPSRLILEIKKQLFSEGGNFSPKEINSL 1032
+ + +T ++ +P + K+L G + S K N++
Sbjct: 1103 YQKKSVTNTQGNGKEQRSKMPVQ-----SKRLLKNGPSGSKKFWNNV 1144
Score = 53.9 bits (128), Expect = 1e-06
Identities = 51/171 (29%), Positives = 86/171 (50%), Gaps = 11/171 (6%)
Query: 790 RQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFIT 849
++ EA+E+ + + K + +D+T E +S G A+SV E E+ + +
Sbjct: 604 QEVEANEENVKVHGGRKEKTEILSDDLTDKAE-VSEGK--AKSVGEAEDGPEGRGDGTCE 660
Query: 850 EEVLGQQKKSPLHAKMDESKEGSI-QGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEE 908
E G + H + +E ++G +G EM+ EG + EE K GE++E+ E
Sbjct: 661 EGSSGAE-----HWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKER 715
Query: 909 EDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKE-EGLEEIYYEDME 958
E ++E +E +EE EE+ + E+E EEE+KE EG EE E++E
Sbjct: 716 EQGHQKERNQE-MEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVE 765
Score = 53.5 bits (127), Expect = 2e-06
Identities = 48/143 (33%), Positives = 65/143 (45%), Gaps = 10/143 (6%)
Query: 809 KQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDES 868
++ +E EE G E EEE + E E EE G+ ++ E
Sbjct: 922 EEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEE---EEGEGEGEEEG----EGEG 974
Query: 869 KEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEK 928
+EG +G EE E EG EE + +GE +EE E E E+EEE E E E +E +
Sbjct: 975 EEGEGEGEEE---EGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGE 1031
Query: 929 EAQEEQESLSVGEEEDKEEGLEE 951
EE+E GEE +KE EE
Sbjct: 1032 GEGEEEEGEEEGEEREKEGEGEE 1054
Score = 52.4 bits (124), Expect = 4e-06
Identities = 38/150 (25%), Positives = 73/150 (48%), Gaps = 9/150 (6%)
Query: 808 KKQGSKEDMT--RSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKM 865
K G ED R + + G+S A ++ E E ++ + E G+ +K +
Sbjct: 642 KSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEE 701
Query: 866 DESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEE-------EE 918
+ ++G Q +E + + N + E + GE +EE + +E+EE+E E
Sbjct: 702 WKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEG 761
Query: 919 EKLEEEKEEKEAQEEQESLSVGEEEDKEEG 948
E++E E+E++E + ++E + EE+ +EEG
Sbjct: 762 EEVEGEREKEEGERKKEERAGKEEKGEEEG 791
Score = 52.0 bits (123), Expect = 5e-06
Identities = 53/171 (30%), Positives = 75/171 (43%), Gaps = 14/171 (8%)
Query: 791 QPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITE 850
+ E E ++ ++ ++ +E EE G E EEE E E E
Sbjct: 850 EEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE---EGEGEGEE 906
Query: 851 EVLGQQKKSPLHAK-MDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEE 909
E G+ ++ K +E +EG +G EE + E EG EE ++EE E E
Sbjct: 907 EGEGEGEEEEGEGKGEEEGEEGEGEG-EEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGE 965
Query: 910 ---------DEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEE 951
+E E E EEE+ E E EE+E +EE E GEEE + EG EE
Sbjct: 966 GEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEE 1016
Score = 51.6 bits (122), Expect = 6e-06
Identities = 48/143 (33%), Positives = 66/143 (46%), Gaps = 13/143 (9%)
Query: 810 QGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESK 869
+G +E EE G E EEE + EE G+ ++ E +
Sbjct: 886 EGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEG---EGE 942
Query: 870 EGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEES----EEEDEKEEEEEEEKLEEEK 925
+G +G EE + E EG E +G+GE +E EEE E E EEEE + EE +
Sbjct: 943 DGEGEG-EEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGE-EEGE 1000
Query: 926 EEKEAQEEQESLSVGEEEDKEEG 948
EE E +EE E GE E++EEG
Sbjct: 1001 EEGEGEEEGE----GEGEEEEEG 1019
Score = 50.1 bits (118), Expect = 2e-05
Identities = 49/145 (33%), Positives = 70/145 (48%), Gaps = 20/145 (13%)
Query: 808 KKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDE 867
+++G K+ E G EE ++ + +E E E+ G QK+ + E
Sbjct: 674 REKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQ--GHQKE-----RNQE 726
Query: 868 SKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEE 927
+EG G EE EG EE + +GE KEE E E E E E E+E+ E +KEE
Sbjct: 727 MEEG---GEEE---HGEGEEEEGDREEEEEKEGEGKEEGEGE-EVEGEREKEEGERKKEE 779
Query: 928 KEAQEEQESLSVGEEE-DKEEGLEE 951
+ +EE+ GEEE D+ EG EE
Sbjct: 780 RAGKEEK-----GEEEGDQGEGEEE 799
Score = 49.3 bits (116), Expect = 3e-05
Identities = 53/176 (30%), Positives = 82/176 (46%), Gaps = 25/176 (14%)
Query: 778 EQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEV- 836
E+ +G ++ + E EK + R + R +G KE + E G + E
Sbjct: 660 EEGSSGAEHWQDEEREKGEK-DKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQG 718
Query: 837 -EEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEEN 895
++E +QEME EE H + +E +G E + E+EG E
Sbjct: 719 HQKERNQEMEEGGEEE----------HGEGEEE-----EGDREEEEEKEGEGKEEGEGEE 763
Query: 896 VKGQGEKKEESEEEDEKEEEE-EEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLE 950
V+G+ EK+E E +KEE +EEK EEE ++ E +EE+ + G E+KEEG E
Sbjct: 764 VEGEREKEEG---ERKKEERAGKEEKGEEEGDQGEGEEEE---TEGRGEEKEEGGE 813
>gi|17975763 myelin transcription factor 1 [Homo sapiens]
Length = 1121
Score = 69.7 bits (169), Expect = 2e-11
Identities = 38/96 (39%), Positives = 59/96 (61%), Gaps = 5/96 (5%)
Query: 866 DESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEK 925
+ S++ Q LE+ E L+ E + E++EE EEEDE+EEEEEEE+ EEE+
Sbjct: 230 ERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEE 289
Query: 926 EEKEAQEEQESLSVGEEEDKEEGLEEIYYEDMESFT 961
EE+E +EE+E EEE++EE ++ +++ S T
Sbjct: 290 EEEEEEEEEE-----EEEEEEEAAPDVIFQEDTSHT 320
Score = 57.8 bits (138), Expect = 9e-08
Identities = 43/135 (31%), Positives = 68/135 (50%), Gaps = 17/135 (12%)
Query: 842 QEMESFITEEVLGQQKKSP---LH--------AKMDESKEG------SIQGLEEMQVERE 884
Q E + EE LGQ K +H A +E ++G + + E+ ER
Sbjct: 173 QIAEETLVEEDLGQAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTTERS 232
Query: 885 GSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEED 944
L P E+ + K++ +E++EEEEEE+ EEE++E+E +EE+E EEE+
Sbjct: 233 QDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEE 292
Query: 945 KEEGLEEIYYEDMES 959
+EE EE E+ E+
Sbjct: 293 EEEEEEEEEEEEEEA 307
Score = 50.4 bits (119), Expect = 1e-05
Identities = 36/117 (30%), Positives = 60/117 (51%), Gaps = 2/117 (1%)
Query: 836 VEEENDQEMESFITEEVLGQQKKSPLHAKMDES--KEGSIQGLEEMQVEREGSLNPSLNE 893
++ E+ +E+ TE +S A +ES ++G + EE + E E +E
Sbjct: 216 IQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDE 275
Query: 894 ENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLE 950
E + + E++EE EEE+E+EEEEEEE+ EEE +E S + ++ + G E
Sbjct: 276 EEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPE 332
Score = 45.4 bits (106), Expect = 4e-04
Identities = 38/115 (33%), Positives = 55/115 (47%), Gaps = 17/115 (14%)
Query: 830 ARSVEEVEEENDQEM-----ESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVERE 884
A V EV E Q++ E +EE +QK H + DE +E + EE + E E
Sbjct: 221 AEEVVEVTTERSQDLCPQSLEDAASEES-SKQKGILSHEEEDEEEEEEEEEEEEDEEEEE 279
Query: 885 GSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEK----LEEEKEEKEAQEEQE 935
EE + + E++EE EEE+E+EEEEEE +E+ AQ+ E
Sbjct: 280 -------EEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPE 327
Score = 34.3 bits (77), Expect = 1.0
Identities = 30/138 (21%), Positives = 59/138 (42%), Gaps = 7/138 (5%)
Query: 779 QNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEE 838
++ A E K + +HE+ ++ ++ ++ +ED EE EE EE
Sbjct: 241 EDAASEESSKQKGILSHEEEDEEEEEE---EEEEEEDEEEEEEEEEEEEEEEEEEEEEEE 297
Query: 839 ENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKG 898
E ++E E +V+ Q+ S A+ K ++G E + E S+ + ++ K
Sbjct: 298 EEEEEEEEEAAPDVIFQEDTSHTSAQ----KAPELRGPESPSPKPEYSVIVEVRSDDDKD 353
Query: 899 QGEKKEESEEEDEKEEEE 916
+ +S DE E ++
Sbjct: 354 EDTHSRKSTVTDESEMQD 371
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 69.7 bits (169), Expect = 2e-11
Identities = 189/931 (20%), Positives = 371/931 (39%), Gaps = 167/931 (17%)
Query: 356 SDEEMNRLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTD 415
+ E+++ L L+V+ +N E+ + ++E D+ LL E+KELD LH E
Sbjct: 1765 NQEDIHNLQLRVKETSN-ENLRLLHVIEDRDRKVESLL---NEMKELDSKLHLQEVQLMT 1820
Query: 416 KLKSVL----------KKYAEVIEKTSY--------LMRPEVYRLINEEAMVMNYALLGN 457
K+++ + K+ +++ EK Y L R E +N + + +A +
Sbjct: 1821 KIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEM--HADKSS 1878
Query: 458 RKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEAL-LQSFSEFMASESIHTPPA 516
R+ + + +S ++ LD + + +++ EAL L++ E + +E +
Sbjct: 1879 REDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKD 1938
Query: 517 VTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDC 576
+ +V++ + L + +L S T L + + +EL+++ +C
Sbjct: 1939 NENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSEC 1998
Query: 577 MMWIRL----LYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKV 632
+ I++ + EKT E L + + +LL K +E+ ++L Q + + ++
Sbjct: 1999 LHCIQVAEAEVKEKT--ELLQTLSSDVSELLKDKTHLQEKLQSLEKDS--QALSLTKCEL 2054
Query: 633 EEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEA---------------------- 670
E + L+K E L ++E + L + E + + +A
Sbjct: 2055 ENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEV 2114
Query: 671 HQSELLVQELEL-------------EKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQS-- 715
HQ +++L + EK E+ R+ SL+ +V+ + + + Q+
Sbjct: 2115 HQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVI 2174
Query: 716 -DKETLAFHLEKVKDYLKNMKSRYECFH----TL------LTKEVMEYPAIMLKELNSYS 764
D E +E +K ++ M + F TL LTK++ E +L+
Sbjct: 2175 LDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQG----QLSELD 2230
Query: 765 SALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQ----GSKEDMTRSE 820
LS + + + E+ E+ K A E Q ++K+L + G +E M +E
Sbjct: 2231 KLLSSF---KSLLEEKEQAEIQIKEESKTAVEM-LQNQLKELNEAVAALCGDQEIMKATE 2286
Query: 821 ESISSGTSTARSVEEVEEENDQEMESFITEE--VLGQQKKSPLHAKMDESKEGSIQGLE- 877
+S+ + E+ +E+ ++ VL Q K+S HA + +G ++ LE
Sbjct: 2287 QSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADL---LKGRVENLER 2343
Query: 878 EMQVEREGSLNPSLNEENVKGQGE-------------------------KKEESEEEDEK 912
E+++ R + +L EN KG+ E +KE E +K
Sbjct: 2344 ELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQK 2403
Query: 913 EEEEEEEK----------LEEEKEEKEAQEEQESLSVGEEEDKEEGLEE---IYYEDMES 959
E+E E L+E+++EK +E+ S ++ + + + L E + D E+
Sbjct: 2404 EQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEA 2463
Query: 960 FTISSGNTYFVFVPLEEEHCRKSHSTFSAM--FINDTSSAKFIEQVTIPSRLILEIKKQL 1017
N LE E + A +I SS + Q + LE K +
Sbjct: 2464 CKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEE 2523
Query: 1018 FSEGGN--FSPKEINSLCSRLEKE-----AARIELVESVIMLNMEKLENEYLDQAN--DV 1068
S N +++ S S++E E +EL + L +K++ A+ D
Sbjct: 2524 ISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELE-QKIQVLQSKNASLQDT 2582
Query: 1069 INKFESKFHNLSVDL--------IFIEKIQRLL---TNLQVKIKCQVAKS-------NSQ 1110
+ +S + NL +L F+EK+ ++ T LQ ++ K+ + +
Sbjct: 2583 LEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGE 2642
Query: 1111 TNGLNFSLQQLQNKIKTCQESRGEKTTVTTE 1141
N L LQ L +IK+ ++ E T +E
Sbjct: 2643 KNRLAGELQLLLEEIKSSKDQLKELTLENSE 2673
Score = 58.2 bits (139), Expect = 7e-08
Identities = 178/919 (19%), Positives = 353/919 (38%), Gaps = 137/919 (14%)
Query: 263 MENPVLHREKERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYES 322
+EN + KE+ K ES ++ + EK++ S A ++ +
Sbjct: 2054 LENQIAQLNKEKELLVKESES--------LQARLSESDYEKLNVSKALEAALVEKGEFAL 2105
Query: 323 ALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQALL 382
L+S QEE+ Q+ + +E L V K+L +++ R + END+
Sbjct: 2106 RLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKER---ERENDS----------- 2151
Query: 383 ELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRPEVYRL 442
L DKV L R+ ++ E ++ L L+ + LK E + ++ + ++ L
Sbjct: 2152 -LKDKVEN--LERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTL 2208
Query: 443 INEEAMVM-----NYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKE- 496
+E+ + L L F +L+E Q E+ + + V+ + KE
Sbjct: 2209 RSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKEL 2268
Query: 497 ----ALLQSFSEFMASESIHTPPAVTKELEV---MLKTQNVLQQRRLKHLCTICDLLPPS 549
A L E M + P + +E ++ + K + L+ K LC + L
Sbjct: 2269 NEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESE 2328
Query: 550 YSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFT 609
+ L + +L +EL+ + + + +N K ++ KA
Sbjct: 2329 HHADLL---KGRVENLERELE------------IARTNQEHAALEAENSKGEVETLKAKI 2373
Query: 610 EEEAETL---------VNQFFFQMVGALQGKVE--EDLELLDKSFETLADQTEWQSSHLF 658
E ++L + + LQ + E +LE+++ SFE + + E + +
Sbjct: 2374 EGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMK 2433
Query: 659 KYFQEVVQLWEAHQSELLVQELELEKRMEQHRQK-HSLESQV-----QEAHLDRLLDQLR 712
+ +++ + EL + L E + K +L SQV ++A L + LD+ +
Sbjct: 2434 EKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAK 2493
Query: 713 QQ------------SDKETLAFHLEKVKDYLKNMK-------------SRYECFHTLLTK 747
+ E LEK + + +K S+ E H L +
Sbjct: 2494 NNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKE 2553
Query: 748 EVMEYPAI------MLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQK 801
+ +E + ++ L S +++L V + +NL E+ E +
Sbjct: 2554 QNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL-------ELTKMDKMS 2606
Query: 802 RVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQ---EMESFITEEVLGQQKK 858
V+K+ K + ++ R ++ TA EE+ E ++ E++ + E + +
Sbjct: 2607 FVEKVNKMTAKETELQREMHEMAQ--KTAELQEELSGEKNRLAGELQLLLEEIKSSKDQL 2664
Query: 859 SPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVK-GQGEKKEESEEED-EKEEEE 916
L + E K+ S+ + + QVE+EG + + E ++ + EKK ++ D K+ E
Sbjct: 2665 KELTLENSELKK-SLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2723
Query: 917 EEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEE 976
E + E+ KE + L + + +E L N+ + E
Sbjct: 2724 EIQTYREKLTSKEECLSSQKLEIDLLKSSKEEL---------------NNSLKATTQILE 2768
Query: 977 EHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRLILEIKKQLFSEGGNFSPKEINSLCSRL 1036
E K + ++N K E+ +L+++ KQL E KE++ L +
Sbjct: 2769 E--LKKTKMDNLKYVNQLK--KENERAQGKMKLLIKSCKQL-EEEKEILQKELSQLQAAQ 2823
Query: 1037 EKEAARIELVESVIMLNMEKLE-NEYLDQANDVINKFESKFHNLSVDLIFIEKIQRLLTN 1095
EK+ + V L E E E L++ +++ K+ +L + +EK + +L
Sbjct: 2824 EKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLET 2883
Query: 1096 LQVKIKCQVAKSNSQTNGL 1114
+ Q +K +S+ + L
Sbjct: 2884 QVAHLCSQQSKQDSRGSPL 2902
Score = 51.2 bits (121), Expect = 8e-06
Identities = 178/1003 (17%), Positives = 384/1003 (38%), Gaps = 146/1003 (14%)
Query: 290 REVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGLF 349
+E+ G +D + EK +Q + + S E+AL ++++ E L + L
Sbjct: 21 QELEGQLDKLKKEK-------QQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLM 73
Query: 350 --LKKLTESDEEMNRLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALH 407
+ L ++ ++++ E+ N ++ + + + +K+ L K E++ +A
Sbjct: 74 EICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQ 133
Query: 408 SLEFSRT-----DKLKSVLKKYAEVIEKTSYLMRPEVYRLINEEAMVMNYALLGNRKALA 462
S + S K+ + ++ + Y E Y EE + + + A
Sbjct: 134 SADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKA 193
Query: 463 QLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSE-----------FMASESI 511
L ++T+ +RH+ V +W+ K + L S S+ + + E
Sbjct: 194 SQ--TLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQE 251
Query: 512 HTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDT 571
TP T ++ + HL K Q E + +N L L
Sbjct: 252 VTPSRSTLQIGKRDANSSFFDNSSSPHLL--------DQLKAQNQELRNKINELELRLQG 303
Query: 572 YHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFF--------FQ 623
+ + + +QE + ++ K +L++ + + + LV +
Sbjct: 304 HEKEMKGQVN-----KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYT 358
Query: 624 MVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELE 683
+ K+ EDL ++ E+ E + K FQE + + L + ++++
Sbjct: 359 ALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMK 418
Query: 684 KRMEQHRQKHSLESQVQEAHLDRL----------LDQLRQQSDKETLAFHLEKVKD---- 729
R+ Q Q+ V +A LD+L L++ +Q+ + AF ++K+
Sbjct: 419 ARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELR 478
Query: 730 -YLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQ-YFFVREIFEQNLAGEVIF 787
++ MK + ++ E + EL + L+Q F E+ +N + E +
Sbjct: 479 RSMEEMKKENNLLKSHSEQKAREV-CHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETML 537
Query: 788 KFRQPEAHEKPSQKRVKKLR-------KKQGSKEDMTRSEESISSGTSTARSVEEVEEEN 840
+ Q + +++ + ++KL+ K++ +D+ + E +E+ N
Sbjct: 538 RDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKRE------------HHIEQLN 585
Query: 841 DQ----EMESFITEEVLGQQKKSPLHAKMDES-----KEGSIQGLEEMQVEREGSLNPSL 891
D+ E ES L +KK K +++ K + + L +M+ E+E +L +
Sbjct: 586 DKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKE-NLQSKI 644
Query: 892 N--EENVKGQGEKKEESEEE------DEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEE 943
N E +K Q K E E D + E L + K + E + L+ E +
Sbjct: 645 NHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQ 704
Query: 944 DKEEGLEEIYYEDMESFTISSGNTYFVFVPLE------------EEHCRKS-HSTFSAMF 990
K E ++ + +++E+ + + LE ++ C + H+ + +
Sbjct: 705 QKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYES-- 762
Query: 991 INDTSSAKFIEQVTIP----SRLILEIKKQLFSEGGNFSPKEINSLCSRLEKEAARIELV 1046
+ D +K VT S L + + + N ++ S+ S E+ R+E
Sbjct: 763 LRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQ-GSMPS--ERSECRLEAD 819
Query: 1047 ESVIMLNMEKLENEYLDQANDVINKFESKFHNLSVDLIFIEKIQRLLTNLQVKIKCQVAK 1106
+S +N + Q N+ +S +L +Q+ L V+IK ++ +
Sbjct: 820 QSP--------KNSAILQ-----NRVDSLEFSLESQKQMNSDLQKQCEEL-VQIKGEIEE 865
Query: 1107 SNSQTNGLNFS-LQQLQNKIKTCQESRGEKTTVTTEELLSFVQTWKEKLSQRIQYLN--C 1163
+ + ++ S + + +I QE V E L + E + +Q LN
Sbjct: 866 NLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSAL-----ENKEKELQLLNDKV 920
Query: 1164 SLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEAKLDVVT 1206
++ + EL +N +L+D ++ +L+ + +LE++ +++
Sbjct: 921 ETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIIS 963
Score = 51.2 bits (121), Expect = 8e-06
Identities = 180/994 (18%), Positives = 370/994 (37%), Gaps = 147/994 (14%)
Query: 680 LELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYE 739
+E+ + +E+ +QK S E QV+E+ ++ QL + +EK++ LK KS E
Sbjct: 73 MEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQ------IEKLEQELKRCKSELE 126
Query: 740 CFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPS 799
+++ + + L N+ + + + + ++ K+ + K
Sbjct: 127 -----RSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRL 181
Query: 800 QKRVKKLRKKQGSK---------EDMTRSEESISSGTSTARSVEEVEEENDQEM---ESF 847
+ VK L+ K+ S+ D+ R + S S + N Q F
Sbjct: 182 EAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDF 241
Query: 848 ITEEVLGQQKKSPLHAKMDESKEGSIQG----------LEEMQVEREGSLNPSLNEENVK 897
G+Q+ +P + + K + L++++ + + L +NE ++
Sbjct: 242 SASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQ-ELRNKINELELR 300
Query: 898 GQGEKKE------ESEEEDEKEEEEEEEKLEEEKEEKEAQEE--QESLSVGEEEDKEEGL 949
QG +KE + +E + E+ + E +E+EK + ++E + + + K L
Sbjct: 301 LQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTAL 360
Query: 950 EEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRL 1009
E+ + E + N LE++ ++ F S + ++Q I +
Sbjct: 361 EQKLKKLTEDLSCQRQNAESARCSLEQK-IKEKEKEFQEELSRQQRSFQTLDQECIQMKA 419
Query: 1010 ILEIKKQLFSEGGNFSPKEINSLCS-----------------RLEKEAARIELVESVIML 1052
L + Q N E++ L S R E+ ++ E+ +
Sbjct: 420 RLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRR 479
Query: 1053 NMEKLENE------YLDQANDVINKFESKFHNLSVDLI----FIEKIQRLLTNLQVKIKC 1102
+ME+++ E + +Q + E++ N+ L F E+++ T+ + ++
Sbjct: 480 SMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRD 539
Query: 1103 QVAKSNSQTNGLNFS--------------------------LQQLQNKI----------- 1125
K N Q N L ++QL +K+
Sbjct: 540 LQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALL 599
Query: 1126 -------KTCQESRGEKTTVT-----TEELLSFVQTWKEKLSQRIQYLNCSLDRVSMTEL 1173
K +E + EKT + E+LL+ +++ KE L +I +L L +
Sbjct: 600 SALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSH 659
Query: 1174 VFTN---TILKDQEEDSDILTSSEALEEEAKLDVVTPE----SFTQLSRVGKPLIEDPAV 1226
+ T+ D+E S + + + + ++V T + Q + +
Sbjct: 660 EYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIE 719
Query: 1227 DVIRKLLQLPNTKWPTHHCDKDPSQTGFKRHRC-QPENSGKKAVPSASATSAGSLQTTHP 1285
++ K QL H + S + RC Q ++ +++ + SL T
Sbjct: 720 NMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNED 779
Query: 1286 PLSHSFTPHPKPNKMERKYRVLGDKPPPAAEDFKGIILTLLWESSENLLTVAEEFYRKEK 1345
+P ++G++ +E + +S +N + E
Sbjct: 780 HQRSLLAFDQQPAMHHSFANIIGEQGSMPSE--RSECRLEADQSPKNSAILQNRVDSLEF 837
Query: 1346 RPVTRPDCMCDTFDQCAE--NISKKILEYQSQANKYHNSCLIELRIQIRRFEELLPQVCW 1403
++ D QC E I +I E +A + H S + E +I + +E
Sbjct: 838 SLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQN 897
Query: 1404 LVMENFKEHHWKKFFTSVKEIRGQFEEQQKRLEKRKDKNAQKLHLNLGHPVHFQEMESLH 1463
+V E K+ ++ + + E +Q +++ K N HL +E++ L
Sbjct: 898 VVAETLSALENKE--KELQLLNDKVETEQAEIQELKKSN----HLLEDS---LKELQLLS 948
Query: 1464 LSEEERQEELDSMIRMNKEKLEECTRRNGQVFITNLATFTEKF-LLQLDEVVT--IDDVQ 1520
+ ++E+ S+I +NK ++EE T+ NG + N + EK L+Q E ID+ +
Sbjct: 949 ETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDERE 1008
Query: 1521 VARMEPPKQ----KLSMLIRRKLAGLSLKEESEK 1550
+ E Q KL +L R + G + ++ S+K
Sbjct: 1009 KSISELSDQYKQEKLILLQRCEETGNAYEDLSQK 1042
Score = 49.7 bits (117), Expect = 2e-05
Identities = 185/986 (18%), Positives = 401/986 (40%), Gaps = 148/986 (15%)
Query: 303 KISTSTFQR--QAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEM 360
K++ S +R E++ S AS + E + ++E +V T L L+K +E
Sbjct: 1888 KVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLE--VVQTEKLCLEK---DNENK 1942
Query: 361 NRLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSV 420
++ + +E + ++ L D ++ + Q +++ E LE +++ L +
Sbjct: 1943 QKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCI 2002
Query: 421 LKKYAEVIEKTSYL--MRPEVYRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELD 478
AEV EKT L + +V L+ ++ + + + A ++L + L+ ++
Sbjct: 2003 QVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQA---LSLTKCELENQIA 2059
Query: 479 SRHRWQGLVDTWKALKKEALLQSFSEFMA--SESIHTPPAVTKELEVML----------- 525
++ +KE L++ A SES + V+K LE L
Sbjct: 2060 QLNK-----------EKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLS 2108
Query: 526 KTQNVLQQRR----LKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIR 581
TQ + Q R + D + +L E +SL +++ + M
Sbjct: 2109 STQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQM--- 2165
Query: 582 LLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETL------------VNQFFFQMVGALQ 629
E+ + ++ +N K ++ K EE A +L + + + Q
Sbjct: 2166 --SEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ 2223
Query: 630 GKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSEL------LVQELELE 683
G++ E L+ L SF++L ++ E + + + V++ + EL L + E+
Sbjct: 2224 GQLSE-LDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIM 2282
Query: 684 KRMEQH-----RQKHSLESQVQEAHLDRLLDQLRQ----QSDKETLAFHLEKVKDYLKNM 734
K EQ ++H L + +++ D+ +Q Q KE+ H + +K ++N+
Sbjct: 2283 KATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKES-EHHADLLKGRVENL 2341
Query: 735 KSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAG---EVIFKFRQ 791
+ E + + E+ A+ + L E Q+L G +V+ +
Sbjct: 2342 ERELE-----IARTNQEHAALEAENSKGEVETLKAKI---EGMTQSLRGLELDVVTIRSE 2393
Query: 792 PE---AHEKPSQKRVKKLRKKQGSKEDMTRSEE----SISSGTSTARSVEEVE-EENDQE 843
E + Q+R+ +L S E++ + +E + +STA + + + +E ++
Sbjct: 2394 KENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNER 2453
Query: 844 MESFITEEVLGQQKKSPLHAK---MDESKEGSIQGLEEMQ---VEREGSLNPSLNE-ENV 896
+ + ++ + K+ L ++ ++ K +QGL+E + + + S+N + E E+
Sbjct: 2454 VAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDG 2513
Query: 897 KGQGEKKEESEEEDEKEEEEEEE---KLEEEKEE----KEAQEEQESLSVGEEEDKEEGL 949
K + EKK+E + + +++E+ KL + + E KE E +L+V E E K + L
Sbjct: 2514 KQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTV-ELEQKIQVL 2572
Query: 950 EEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRL 1009
+ ++ + + + LE E + + F+E+V +
Sbjct: 2573 QSKNASLQDTLEVLQSS----YKNLENE-----------LELTKMDKMSFVEKVNKMTAK 2617
Query: 1010 ILEIKKQLFSEGGNFS--PKEINSLCSRLEKEAARI--ELVESVIMLNMEKLENEYLDQA 1065
E+++++ + +E++ +RL E + E+ S L LEN L ++
Sbjct: 2618 ETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKS 2677
Query: 1066 NDVINKFESKFHNLSVDLIFIEKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKI 1125
D ++K + + K++ + Q+++ K + N +Q + +I
Sbjct: 2678 LDCMHKDQVEKEG---------KVREEIAEYQLRLHEAEKKHQALLLDTN---KQYEVEI 2725
Query: 1126 KTCQESRGEKTTVTTEELL--SFVQTWKEKLSQRIQYLNCSLD---RVSMTELVFTNTIL 1180
+T +E K + + L +++ KE+L+ ++ L+ + M L + N +
Sbjct: 2726 QTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLK 2785
Query: 1181 KDQEEDSD----ILTSSEALEEEAKL 1202
K+ E ++ S + LEEE ++
Sbjct: 2786 KENERAQGKMKLLIKSCKQLEEEKEI 2811
Score = 42.0 bits (97), Expect = 0.005
Identities = 178/981 (18%), Positives = 364/981 (37%), Gaps = 130/981 (13%)
Query: 273 ERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALASFQEEIA 332
++A R + +++N + E GL I+ K + Q++ + E + + +
Sbjct: 1107 QQALRSEMTDNQNN-SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHE 1165
Query: 333 QVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQA----LLELWDKV 388
E EP+ + E + E N+ K + D +++ ++ + L++L +
Sbjct: 1166 CQNLESEPI--------RNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAML 1217
Query: 389 AGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLK----------KYAEVIEKTSYLMRP- 437
+ L ++ KE + H L+ R D S L+ K E+ + Y+ P
Sbjct: 1218 RNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPH 1277
Query: 438 EVYRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEA 497
E+ N+ A ++ +LQ ++ + + + + +A K E
Sbjct: 1278 ELSTSQNDNAH--------------------LQCSLQTTMNKLNELEKICEILQAEKYEL 1317
Query: 498 LLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTE 557
+ + SE I + +E+ +L +L + + +P Q E
Sbjct: 1318 VTELNDS--RSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNE 1375
Query: 558 WHS-SLNSLNKELDTYHV-----DCMMWIRLLYEKTW----QECLMHVQNCK--KQLLDW 605
H SL L++ H+ + M L EK + ++H Q+C+ ++ +
Sbjct: 1376 QHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSEL 1435
Query: 606 KAFTEE-EAETLV-----NQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFK 659
+ + + +AE LV F +V +Q +EE L + S + D + S
Sbjct: 1436 QTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGL-VPSLSSSCVPDSSSLSSLGDSS 1494
Query: 660 YFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKET 719
+++ ++ E L+ LE Q S +QE +L R E
Sbjct: 1495 FYRALL---EQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEE 1551
Query: 720 LAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQ 779
L E + L+ ++ + E + KE+ E ++ E QY E ++Q
Sbjct: 1552 LESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQ 1611
Query: 780 NLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEE 839
L + + A +K +++ +L + + + S S+ G T +++ E
Sbjct: 1612 KLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSL-LGIDTEDAIQGRNES 1670
Query: 840 NDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPS-------LN 892
D E T E + K +H D+ + + L+ ++ G++ P+
Sbjct: 1671 CDISKEH--TSETTERTPKHDVHQICDKDAQQDL-NLDIEKITETGAVKPTGECSGEQSP 1727
Query: 893 EENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEI 952
+ N + GE K + E E + QE+ +L + +E E L +
Sbjct: 1728 DTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLL 1787
Query: 953 YYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRL--I 1010
+ + E+ RK S + M + S +++V + +++
Sbjct: 1788 H--------------------VIEDRDRKVESLLNEM--KELDSKLHLQEVQLMTKIEAC 1825
Query: 1011 LEIKK---QLFSEGGNFSPKEINSLCSRLE--KEAARIELVESVIMLNMEKLENEYL-DQ 1064
+E++K +L E + S K C E + E + S + ++ +K E + D
Sbjct: 1826 IELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDN 1885
Query: 1065 ANDVINKFESKFHNLSVDLIFIEKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNK 1124
V + ++ +F ++ +L +I+ + A + L L+ +Q +
Sbjct: 1886 VAKVNDSWKERFLDVENEL--------------SRIRSEKASIEHEALYLEADLEVVQTE 1931
Query: 1125 IKTCQESRGE---KTTVTTEELLSFVQTWKEKLSQRIQYLN---CSLDRVSMTELVFTNT 1178
K C E E K V EE LS V + + +L + ++ +LD++S T
Sbjct: 1932 -KLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQE 1990
Query: 1179 ILKDQEEDSDILTSSEALEEE 1199
+ Q E + +EA +E
Sbjct: 1991 LESHQSECLHCIQVAEAEVKE 2011
Score = 36.6 bits (83), Expect = 0.21
Identities = 193/892 (21%), Positives = 339/892 (38%), Gaps = 166/892 (18%)
Query: 116 EKKLQQSTK-YWCLNQSAESLRICAMRGGENRPPARVQSSSEELELRHQSLDAFPGRRLP 174
E+KL++ T+ C Q+AES R C++ E + + + EEL + +S L
Sbjct: 361 EQKLKKLTEDLSCQRQNAESAR-CSL---EQKIKEKEKEFQEELSRQQRSFQT-----LD 411
Query: 175 GRGIQPAAKMSSVGKVTQVPNGKAYQQIFQAEVQLVHSLAATRKRAAERSVTLKSGRIPM 234
IQ A+++ ++ K + QAE+ + S+ K+ E ++
Sbjct: 412 QECIQMKARLTQ-----ELQQAKNMHNVLQAELDKLTSV----KQQLENNL--------- 453
Query: 235 MKKVETPEGEVMSPRQQKWMHSLPNDWIMENPVLHREKERAKREKARESENTIAAREVRG 294
E + + + I EN + +E K +S + AREV
Sbjct: 454 ---------EEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCH 504
Query: 295 LMDTIVPEKISTSTFQRQAEH---KRKSYESALASFQEEIAQVGKEM--EPLIVDTGGL- 348
L + K + Q AE K S E+ L QE+I Q + E L + L
Sbjct: 505 LEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLE 564
Query: 349 --------FLKKLTESDEEMNRLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIK 400
LKK E++N K E ++ +ALL L L+K+E +
Sbjct: 565 KQRDCSQDLLKKREHHIEQLNDKLSKTEKES-------KALLSA-------LELKKKEYE 610
Query: 401 ELDE--ALHSLEFSRTDKLKSVLKKYAEVIE-KTSYLMRP-EVYRLINEEAMVMNYALLG 456
EL E L S S +KL + ++ E ++ K ++L + ++ + E L
Sbjct: 611 ELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEM 670
Query: 457 NRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPA 516
+R+ L+ NL LDS+ V+T K E LQ +EF S+ H
Sbjct: 671 DRENLSVEIRNL-----HNVLDSK---SVEVETQKLAYME--LQQKAEF--SDQKHQ--- 715
Query: 517 VTKELEVM-LKTQNVLQQ-RRLKHLCTIC--DLLPPSYSKTQLTEWHSSLNSLNKELDTY 572
KE+E M LKT + Q L+H + +++ L + SL L K D
Sbjct: 716 --KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDAS 773
Query: 573 HVDCMMWIRLLYEKTWQECLMHV---------------QNCKKQLLDWKAFTEEEAETLV 617
V R L Q + H C+ + D + V
Sbjct: 774 LVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEA-DQSPKNSAILQNRV 832
Query: 618 NQFFF------QMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWE-- 669
+ F QM LQ + EE +++ + E L + S + + Q + +L E
Sbjct: 833 DSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDT 892
Query: 670 -AHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLL--DQLRQQSDKETLAFHLEK 726
AHQ+ ++ + L + E+ Q + + + ++A + L + L + S KE L+
Sbjct: 893 SAHQN-VVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKE-----LQL 946
Query: 727 VKDYLKNMKSRYECFHTLLTKEVMEYPAI--MLKELNSY-----------SSALSQYFFV 773
+ + L K +L +E+ E LKE+N+ S + + Y
Sbjct: 947 LSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDE 1006
Query: 774 RE-----IFEQNLAGEVIFKFRQPE---AHEKPSQKRVKKLRKKQGSKEDMTRSEESISS 825
RE + +Q ++I R E A+E SQK K ++K E + E S
Sbjct: 1007 REKSISELSDQYKQEKLILLQRCEETGNAYEDLSQK-YKAAQEKNSKLECLLN--ECTSL 1063
Query: 826 GTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREG 885
+ +E+++E +E + F+T+ +++ L +++
Sbjct: 1064 CENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELE------------------- 1104
Query: 886 SLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESL 937
++ +L E Q K E+ ++ +EE+ + +KE + +E E L
Sbjct: 1105 TVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL 1156
Score = 35.4 bits (80), Expect = 0.46
Identities = 123/600 (20%), Positives = 228/600 (38%), Gaps = 114/600 (19%)
Query: 111 ITNHREKKLQQSTKYWCLNQSAESLRICAMRGGENRPPARVQSSSEELELRHQSLDAFPG 170
+TN +K+ ++ ++ +N S E++ ++ E + SS +E+ L
Sbjct: 2397 LTNELQKEQERISELEIINSSFENI----LQEKEQEKVQMKEKSSTAMEMLQTQLKELNE 2452
Query: 171 RRLPGRGIQPAAKMSSVGKVTQVPNGKAYQQIFQAEVQLVHSLAATRKRAAERSVTLKSG 230
R Q A K +QV + + + QL+ L A + L+S
Sbjct: 2453 RVAALHNDQEACKAKEQNLSSQV------ECLELEKAQLLQGL----DEAKNNYIVLQSS 2502
Query: 231 RIPMMKKVETPEGEVMSPRQQKWMHSLPNDWIMENPVLHREKERAKREKARESENTIAAR 290
++++VE +G+ ++ + + L N I + L + + + E E + R
Sbjct: 2503 VNGLIQEVE--DGKQKLEKKDEEISRLKNQ-IQDQEQLVSKLSQVEGEHQLWKEQNLELR 2559
Query: 291 EVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGLFL 350
+ ++ +KI + K S + L Q + E+E +D
Sbjct: 2560 NLTVELE----QKIQV------LQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVE 2609
Query: 351 K--KLTESDEEMNRLFLKVENDT-NLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALH 407
K K+T + E+ R ++ T L++ L +++AG L L +EIK + L
Sbjct: 2610 KVNKMTAKETELQREMHEMAQKTAELQE----ELSGEKNRLAGELQLLLEEIKSSKDQLK 2665
Query: 408 SLEFSRTDKLKSVLKKYAEVIEKTSYLMRPEV--YRLINEEAMVMNYALLGNRKALAQLF 465
L ++ KS+ + + +EK +R E+ Y+L EA + AL
Sbjct: 2666 ELTLENSELKKSLDCMHKDQVEKEG-KVREEIAEYQLRLHEAEKKHQAL----------- 2713
Query: 466 VNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVML 525
L+++ Q E++ + + L + L + L + E ++ A T+ LE +
Sbjct: 2714 --LLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELK 2771
Query: 526 KTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYE 585
KT + LK+ +N L KE E
Sbjct: 2772 KT----KMDNLKY-----------------------VNQLKKE---------------NE 2789
Query: 586 KTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVG-ALQGKVEEDLELLDKSFE 644
+ + + +++C KQL + K ++E L Q G + KV+E + + E
Sbjct: 2790 RAQGKMKLLIKSC-KQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKE 2848
Query: 645 TLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHL 704
TL ++T+ +L KY LL+ +LEK K LE+QV AHL
Sbjct: 2849 TLEEKTKEADEYLDKY------------CSLLISHEKLEK------AKEMLETQV--AHL 2888
Score = 33.9 bits (76), Expect = 1.3
Identities = 133/664 (20%), Positives = 248/664 (37%), Gaps = 107/664 (16%)
Query: 631 KVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHR 690
++E E+ +S E L ++ E Q K QE+ QL + + EL + EQ +
Sbjct: 1551 ELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQ 1610
Query: 691 QKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVM 750
QK + + E+ L ++ E L+ LE + L+ + + T++ +
Sbjct: 1611 QKLTSVTLEMESKL------AAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAI 1664
Query: 751 E---YPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLR 807
+ + KE S ++ + V +I +++ ++ + + VK
Sbjct: 1665 QGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDL-----NLDIEKITETGAVKPTG 1719
Query: 808 KKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDE 867
+ G + T E T S E + E + + + + LG Q+ +H
Sbjct: 1720 ECSGEQSPDTNYEP--PGEDKTQGSSECISELSFSGPNALVPMDFLGNQE--DIHNLQLR 1775
Query: 868 SKEGSIQGLEEMQV--EREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKL--EE 923
KE S + L + V +R+ + LNE +E + + E E EK+ E
Sbjct: 1776 VKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGEL 1835
Query: 924 EKEEKEAQEEQESLSVGEEE-----DKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEEH 978
+KE + E+ E S +E + EGL D+E + +
Sbjct: 1836 KKENSDLSEKLEYFSCDHQELLQRVETSEGLN----SDLE---------------MHADK 1876
Query: 979 CRKSHSTFSAMFINDTSSAKFIEQVTIPSRLILEIKKQLFSEGGNFSPKEINSLCSRLEK 1038
+ + +ND+ +F L+++ +L SR+
Sbjct: 1877 SSREDIGDNVAKVNDSWKERF-----------LDVENEL----------------SRIRS 1909
Query: 1039 EAARIELVESVIMLNMEKLENEYLDQANDVINK-------------FESKFHNLSVDLIF 1085
E A IE + ++E ++ E L D NK S+ + L +L
Sbjct: 1910 EKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDT 1969
Query: 1086 IEKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTV--TTEEL 1143
+ K L L K+K + + S + +Q + ++K EKT + T
Sbjct: 1970 MSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVK-------EKTELLQTLSSD 2022
Query: 1144 LSFVQTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEAKLD 1203
+S + K L +++Q L +S+T+ N I + +E ++ SE+L +A+L
Sbjct: 2023 VSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESL--QARLS 2080
Query: 1204 VVTPESFTQLSRVGKPLIEDPAVDVIRKLLQLPNTKWPTHHCDKDPSQTGFKRHRCQPEN 1263
ES + V K L E V+ L+L +T+ H + G ++ R + E
Sbjct: 2081 ----ESDYEKLNVSKAL-EAALVEKGEFALRLSSTQEEVHQL-----RRGIEKLRVRIEA 2130
Query: 1264 SGKK 1267
KK
Sbjct: 2131 DEKK 2134
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 69.3 bits (168), Expect = 3e-11
Identities = 78/326 (23%), Positives = 151/326 (46%), Gaps = 37/326 (11%)
Query: 632 VEEDLELLDKSFETLADQTE--WQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQH 689
+ E E + K E + +Q E WQ L ++ +LWE Q ++ QE ++ ++ E+
Sbjct: 408 MREQEEKMQKQEENMWEQEEKEWQQQRLP---EQKEKLWE--QEKMQEQEEKIWEQEEKI 462
Query: 690 RQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEV 749
R + + Q ++ +++R+Q D+ + EK++D + M + +E
Sbjct: 463 RDQEEMWGQEKKMWRQ---EKMREQEDQ--MWEQEEKMRDQEQKMWDQ---------EER 508
Query: 750 MEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKK 809
M L+E + + E + + K + + ++R+++ KK
Sbjct: 509 MWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKK 568
Query: 810 QGSKEDMTRS-EESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDES 868
+E+M R EE + R EE E +++M+ EE + +Q++ ++
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQE--QEEKMWEQEEK----MWEQE 622
Query: 869 KEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEE---EEEKLEEEK 925
+E +Q EEM E+E + EE + Q EK E EE+ ++EE+ +EEK+ E++
Sbjct: 623 EEDKMQEQEEMMWEQEEKMQEQ--EEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQE 680
Query: 926 EEKEAQEEQESLSVGEEEDKEEGLEE 951
E+ + QEE+ + E+E+K G EE
Sbjct: 681 EKMQGQEEK----MREQEEKMRGQEE 702
Score = 68.6 bits (166), Expect = 5e-11
Identities = 92/391 (23%), Positives = 176/391 (45%), Gaps = 36/391 (9%)
Query: 585 EKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFE 644
EK +E ++ +K+L + K E+E + + + + + K+ E E + + E
Sbjct: 282 EKRLREQEKELREQEKELREQKKLREQEEQMQEQE---EKMWEQEEKMREQEEKMWRQEE 338
Query: 645 TLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHL 704
L +Q + K + ++WE Q E L E E+RM + + E ++QE
Sbjct: 339 RLWEQEKQMREQEQKMRDQEERMWE--QDERL---REKEERMREQEKMWEQEEKMQEEER 393
Query: 705 DRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYEC-FHTLLTKEVMEYPAIMLKELNSY 763
R ++ + + ++ET+ EK++ +NM + E + E E K
Sbjct: 394 IREREK-KMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQE 452
Query: 764 SSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESI 823
Q +R+ ++ + G+ +RQ + E+ Q ++ K + ++ M EE +
Sbjct: 453 EKIWEQEEKIRD--QEEMWGQEKKMWRQEKMREQEDQMWEQE-EKMRDQEQKMWDQEERM 509
Query: 824 SSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVER 883
R E EE ++ + + EE + ++KK+ K +E ++ E M+ ER
Sbjct: 510 WEQDERLR---EKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMR-ER 565
Query: 884 EGSLNPSLNEENVKGQGEKKEESEEEDEKEEE---EEEEKLEE-------------EKEE 927
E + EE ++ Q EK +E EE+ ++EE E+EEK++E E+EE
Sbjct: 566 EKKMREE--EEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE 623
Query: 928 KEAQEEQESLSVGEEEDKEEGLEEIYYEDME 958
++ +EQE + + E+E+K + EE +E E
Sbjct: 624 EDKMQEQEEM-MWEQEEKMQEQEEKMWEQEE 653
Score = 65.1 bits (157), Expect = 5e-10
Identities = 77/344 (22%), Positives = 154/344 (44%), Gaps = 29/344 (8%)
Query: 633 EEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQK 692
E+D L +K + W+ + QE ++ E + +E E+ + +Q+
Sbjct: 363 EQDERLREKEERMREQEKMWEQE---EKMQEEERIREREKKMREEEETMREQEEKMQKQE 419
Query: 693 HSL-ESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECF---HTLLTKE 748
++ E + +E RL +Q + ++E + EK+ + + ++ + E + + +E
Sbjct: 420 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE 479
Query: 749 VMEYPAIMLKELNSYSSALSQYFFVRE--IFEQN-LAGEVIFKFRQP-----EAHEKPSQ 800
M + E Q + +E ++EQ+ E + R+ + + +
Sbjct: 480 KMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREE 539
Query: 801 KRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSP 860
K+ ++ KK +E+ R EE + R EE+ E +++M+ EE + +Q++
Sbjct: 540 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQE--QEEKMREQEE-- 595
Query: 861 LHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEK 920
KM E +E +Q EE E+E + E+ ++ Q E E EE+ +++EE+ E+
Sbjct: 596 ---KMWEQEE-KMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQ 651
Query: 921 LEEEKEEKEAQEEQESLSVG------EEEDKEEGLEEIYYEDME 958
E+ +E++E EQE G E+E+K +G EE E E
Sbjct: 652 EEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEE 695
Score = 53.5 bits (127), Expect = 2e-06
Identities = 72/373 (19%), Positives = 156/373 (41%), Gaps = 38/373 (10%)
Query: 589 QECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLAD 648
Q+ + + C+K L+ + ++A L G++ + L+
Sbjct: 90 QDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESKDLAGRLHHSWHFAGELQRALSA 149
Query: 649 QTEWQSSHLFKYFQEVVQLWEAHQSELL---VQELELEKRMEQHRQKHSLESQVQEAHLD 705
+ W +Y +E+ + +A EL + EL+K+ + ++K L
Sbjct: 150 VSTWHKK-ADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLA--------- 199
Query: 706 RLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSS 765
+S+K + +++++K L+ K T +E M L+E
Sbjct: 200 --------ESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIR 251
Query: 766 ALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISS 825
+ + +E + G K R+ E + +KR+++ K+ +E R ++ +
Sbjct: 252 KQEEKMWRQEERLREQEG----KMREQEEKMRRQEKRLREQEKELREQEKELREQKKLR- 306
Query: 826 GTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREG 885
E+ E+ +QE + + EE + +Q++ + + + E Q E+ Q R+
Sbjct: 307 --------EQEEQMQEQEEKMWEQEEKMREQEEK-MWRQEERLWEQEKQMREQEQKMRDQ 357
Query: 886 SLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDK 945
+E ++ + E+ E E+ E+EE+ +EE+ E+E+K +EE+ ++ E+E+K
Sbjct: 358 EERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEE---TMREQEEK 414
Query: 946 EEGLEEIYYEDME 958
+ EE +E E
Sbjct: 415 MQKQEENMWEQEE 427
Score = 53.1 bits (126), Expect = 2e-06
Identities = 64/281 (22%), Positives = 116/281 (41%), Gaps = 32/281 (11%)
Query: 705 DRLLDQLRQQSDKETLAFHLEKV-KDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSY 763
DR +++L ++ D +L + + + LK + + L E E + +KEL
Sbjct: 158 DRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQ-LNVKELKR- 215
Query: 764 SSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESI 823
L + F+ + N E +++ E+ +++ KK+RK++ E M R EE +
Sbjct: 216 --KLERAKFLLPQVQTNTLQEEMWR------QEEELREQEKKIRKQE---EKMWRQEERL 264
Query: 824 SSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVER 883
R EE ++ + E+ L +Q+K K +E +Q EE E+
Sbjct: 265 REQEGKMREQEEKMRRQEKRLRE--QEKELREQEKELREQKKLREQEEQMQEQEEKMWEQ 322
Query: 884 EGSLNPSLN------------EENVKGQGEKKEESEE----EDEKEEEEEEEKLEEEKEE 927
E + E+ ++ Q +K + EE +DE+ E+EE E+EK
Sbjct: 323 EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 382
Query: 928 KEAQEEQESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTY 968
++ ++ QE + E E K EE E E N +
Sbjct: 383 EQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMW 423
Score = 51.6 bits (122), Expect = 6e-06
Identities = 82/395 (20%), Positives = 162/395 (41%), Gaps = 50/395 (12%)
Query: 566 NKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMV 625
N+EL + + +RL E E ++V+ K++L E A+ L+ Q +
Sbjct: 182 NEELKKKNAELQEKLRLA-ESEKSEIQLNVKELKRKL--------ERAKFLLPQVQTNTL 232
Query: 626 GALQGKVEEDLELLDKSFETLADQTEWQSSHLFKY---FQEVVQLWEAHQSELLVQELEL 682
+ EE+L +K ++ Q L + +E + + L QE EL
Sbjct: 233 QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKEL 292
Query: 683 ---EKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYE 739
EK + + ++ E Q+QE + + + +E + E++ + K M+ + +
Sbjct: 293 REQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 352
Query: 740 CFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPS 799
K + Q +RE E+ E +++ + E+
Sbjct: 353 ------------------KMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERI 394
Query: 800 QKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKS 859
++R KK+R+++ E M EE + EE E + + E +E L +Q+K
Sbjct: 395 REREKKMREEE---ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ---KEKLWEQEKM 448
Query: 860 PLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEE---E 916
+ +E I+ EEM G +E ++ Q ++ E EE+ +E+ +
Sbjct: 449 QEQEEKIWEQEEKIRDQEEMW----GQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWD 504
Query: 917 EEEKLEEE----KEEKEAQEEQESLSVGEEEDKEE 947
+EE++ E+ +E++E EQ+ + EE+ +EE
Sbjct: 505 QEERMWEQDERLREKEERMREQKKMWQQEEKMREE 539
Score = 47.4 bits (111), Expect = 1e-04
Identities = 74/356 (20%), Positives = 152/356 (42%), Gaps = 47/356 (13%)
Query: 585 EKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEE--DLELLDKS 642
EK WQ+ + Q K++L + + E+E + + + + G+ ++ E + +
Sbjct: 427 EKEWQQQRLPEQ--KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
Query: 643 FETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEA 702
+ + +Q E K + + ++WE Q E L E E+RM + ++ E +++E
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERMWE--QDERL---REKEERMREQKKMWQQEEKMREE 539
Query: 703 HLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNS 762
+ +Q ++ D+E E++++ K M+ E K + + +E
Sbjct: 540 K--KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKM 597
Query: 763 YSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEES 822
+ +++EQ E +++ + + ++ + ++ K Q +E M EE
Sbjct: 598 WEQEEKMQEQEEKMWEQE---EKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEK 654
Query: 823 ISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVE 882
+ R EE E +++M+ GQ++K +E +QG EE E
Sbjct: 655 M-------REQEEKMREQEEKMQ--------GQEEKM-------REQEEKMQGQEEKMRE 692
Query: 883 REGSLNPSLNEENVKGQGEK------KEESEEEDEKEEE---EEEEKLEEEKEEKE 929
+E + EE + GQ EK K +EE ++EE +++EK++E E E
Sbjct: 693 QEEKMRGQ--EEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHE 746
Score = 32.0 bits (71), Expect = 5.1
Identities = 37/163 (22%), Positives = 71/163 (43%), Gaps = 6/163 (3%)
Query: 1326 LWESSENLLTVAEEFYRKEKRPVTRPDCMCDTFDQCAENISKKILEYQSQANKYHNSCLI 1385
+WE E + EE + +EK+ + R + M + DQ E K + Q Q +
Sbjct: 455 IWEQEEKIRD-QEEMWGQEKK-MWRQEKMREQEDQMWEQEEK--MRDQEQKMWDQEERMW 510
Query: 1386 ELRIQIRRFEELLPQVCWLVMENFKEHHWKKFFTSVKEIRGQFEE--QQKRLEKRKDKNA 1443
E ++R EE + + + + K KK K+ Q E+ +++R+ +R+ K
Sbjct: 511 EQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMR 570
Query: 1444 QKLHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEKLEE 1486
++ + QE E +EE+ E + ++ +EK+ E
Sbjct: 571 EEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWE 613
Score = 31.2 bits (69), Expect = 8.7
Identities = 31/122 (25%), Positives = 52/122 (42%), Gaps = 23/122 (18%)
Query: 1386 ELRIQIRRFEELLPQV--------CWLVMENFKEHHWK------KFFTSVKEIRGQF--- 1428
EL+ ++ R + LLPQV W E +E K K + + +R Q
Sbjct: 212 ELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKM 271
Query: 1429 ---EEQQKRLEKR---KDKNAQKLHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKE 1482
EE+ +R EKR ++K ++ L +E E +EE+ E + +R +E
Sbjct: 272 REQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEE 331
Query: 1483 KL 1484
K+
Sbjct: 332 KM 333
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 69.3 bits (168), Expect = 3e-11
Identities = 154/791 (19%), Positives = 313/791 (39%), Gaps = 102/791 (12%)
Query: 215 ATRKRAAERSVTLKSGRIPMMKKVETPEGEVMSPRQQKWMHSLPNDWIMENPVLHREKER 274
A RK E+ V+L + + +V++ +M ++ L I+ + ER
Sbjct: 872 ARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEER--CEGLIKSKILLEAKVKELTER 929
Query: 275 AKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALASFQEEIAQV 334
+ E+ SE R + ++ + + E ++ + E+ + + EE+ +
Sbjct: 930 LEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTAL 989
Query: 335 GKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQALLEL-------WDK 387
+ + KLT+ + + + +D +E+ + L+++ D
Sbjct: 990 EEN------------ISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDD 1037
Query: 388 VAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVL------KKYAEVIEKTSYLMRPEVYR 441
+ G L K+ +L+ A LE +S++ ++ E ++K + + +
Sbjct: 1038 LEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAK 1097
Query: 442 LINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWK---ALKKEAL 498
+ +E+ + + +K + +L + E L++E+++ H + ++ + A + E +
Sbjct: 1098 IDDEQVHSLQF-----QKKIKELQARIEE--LEEEIEAEHTLRAKIEKQRSDLARELEEI 1150
Query: 499 LQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEW 558
+ E + S +E E K + L++ L+H T L K Q
Sbjct: 1151 SERLEEASGATSAQIEMNKKREAEFQ-KMRRDLEEATLQHEATAATL-----RKKQA--- 1201
Query: 559 HSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQ---LLDWKAFTEEEAET 615
S+ L +++D + ++ EK E M + + L K+ E T
Sbjct: 1202 -DSVAELGEQIDN-----LQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRT 1255
Query: 616 LVNQFFFQMVGALQGKVEEDLELL-DKSFETLADQTE-WQSSHLFKYFQEVVQLWEAHQS 673
+ +QF ++ K E+ +L+ D + + QT+ + SH + + ++ +
Sbjct: 1256 VEDQF-----SEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQ 1310
Query: 674 ELLVQELELEKRMEQH-RQKHSLESQVQEAHLDRLLDQLRQQSDKET-----LAFHLEKV 727
L Q EL+++ME+ + K+++ +Q + D D LR+Q ++E L L K
Sbjct: 1311 ALTQQLEELKRQMEEETKAKNAMAHALQSSRHD--CDLLREQYEEEQEAKAELQRALSKA 1368
Query: 728 KDYLKNMKSRYECFHTLLTKEVMEYP---AIMLKELNSYSSALSQYFFVREIFEQNLAGE 784
+ +++YE T+E+ E A L+E + + E +Q L GE
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGE 1428
Query: 785 VIFKFRQPEAH--------------EKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTA 830
V R E +K + +KL + Q E + S+S+
Sbjct: 1429 VEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKM 1488
Query: 831 RSV-EEV---------EEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQ 880
R+ EEV E +N QE S +TE++ K K + E L+
Sbjct: 1489 RNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVAL 1548
Query: 881 VEREGSLNPSLNEEN--VKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLS 938
E EGSL +EE+ ++ Q E + E D K E++EE + ++ + A E +S+
Sbjct: 1549 EEVEGSLE---HEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVL 1605
Query: 939 VGEEEDKEEGL 949
E + + L
Sbjct: 1606 DAEIRSRNDAL 1616
Score = 66.2 bits (160), Expect = 2e-10
Identities = 210/1045 (20%), Positives = 416/1045 (39%), Gaps = 159/1045 (15%)
Query: 652 WQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLD-- 709
W +LF + +++ EA + E+ + + E+ E+ + + +++E + L +
Sbjct: 831 WPWMNLFFKIKPLLKSAEA-EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKN 889
Query: 710 --QLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSAL 767
QL+ QS+ E L E+ + +K+ K E LT+ + E +E+NS A
Sbjct: 890 DLQLQVQSETENLMDAEERCEGLIKS-KILLEAKVKELTERLEEE-----EEMNSELVAK 943
Query: 768 SQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGT 827
+ + + ++ + E + ++ +VK L E+MT EE+IS T
Sbjct: 944 KRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNL------SEEMTALEENISKLT 997
Query: 828 STARSVEEVEEE--NDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQ-------GLEE 878
+S++E ++ +D ++E ++V G K + + + EGS++ LE
Sbjct: 998 KEKKSLQEAHQQTLDDLQVEE---DKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLER 1054
Query: 879 MQVEREGSLNPS----LNEENVKGQGEKKEESEE----------EDE--------KEEEE 916
+ + EG L S ++ EN K Q E+K + +E +DE K+ +E
Sbjct: 1055 AKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKE 1114
Query: 917 EEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEE 976
+ ++EE +EE EA+ + + D LEEI E +SG T +
Sbjct: 1115 LQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEI----SERLEEASGAT-----SAQI 1165
Query: 977 EHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRLILEIKKQLFSEGGNFSPKEINSLCSRL 1036
E +K + F M + +E+ T+ Q + K+ +S+ + L
Sbjct: 1166 EMNKKREAEFQKM-------RRDLEEATL----------QHEATAATLRKKQADSV-AEL 1207
Query: 1037 EKEAARIELVESVIMLNMEKLENEYLDQANDVINKFESKFHNLSVDLIFIEKIQRLLTNL 1096
++ ++ V+ + +L+ E D A+++ +SK + IE+ R + +
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSN--------IERTCRTVEDQ 1259
Query: 1097 QVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTWKEKLSQ 1156
+IK + + + LN +LQ + EK E L+S + K+ L+Q
Sbjct: 1260 FSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEK-----ESLISQLTKSKQALTQ 1314
Query: 1157 RIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEAKLDVVTPESFTQLSRV 1216
+++ L ++ + + + L+ D D+L E+EAK ++ LS+
Sbjct: 1315 QLEELKRQMEEETKAKNAMAHA-LQSSRHDCDLLREQYEEEQEAKAELQ-----RALSKA 1368
Query: 1217 GKPLIE---DPAVDVIRKLLQLPNTKWPTHHCDKDPSQTGFKRHRCQPENSGKKAVPSAS 1273
+ + D I++ +L K K + + NS ++
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAK------KKLAQRLQEAEENTETANSKCASLEKTK 1422
Query: 1274 ATSAGSLQTTHPPLSHSFTPHPKPNKMERKY-RVLGDKPPPAAEDFKGIILTLLWESSEN 1332
G ++ L S T +K +R + +VL + W+ +
Sbjct: 1423 QRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAE-----------------WKQKLD 1465
Query: 1333 LLTVAEEFYRKEKRPV-TRPDCMCDTFDQCAENISKKILEYQSQANKYHNSCLIELRIQI 1391
E +KE R + T M + +++ + LE + NK + +L QI
Sbjct: 1466 ESQAELEAAQKESRSLSTELFKMRNAYEEVVDQ-----LETLRRENKNLQEEISDLTEQI 1520
Query: 1392 RRFEELLPQVCWLVMENFKEHHWKKFFTSVKEIRGQFE-EQQKRLEKRKDKNAQKLHLNL 1450
+ L + + E +++E+ G E E+ K L + + + K L+
Sbjct: 1521 AETGKNLQEA--EKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDR 1578
Query: 1451 GHPVHFQEMESLHLSEEERQEELDSMIRMN----------KEKLE--------ECTRRNG 1492
+E+E L + + E L S++ K+K+E + N
Sbjct: 1579 KVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNR 1638
Query: 1493 QVFITNLATFTEKFLLQLDEVVTIDDVQVARMEPPKQKLSMLIRRKLAGLSLKE-ESEKP 1551
Q+ T T + L+ D + +DD + E K++L+++ RR GL L+E E K
Sbjct: 1639 QMAETQKHLRTVQGQLK-DSQLHLDDA-LRSNEDLKEQLAIVERRN--GLLLEELEEMKV 1694
Query: 1552 LIERGSRKWPGIKPTEVTIQNKILL---QPTSSISTTKTTLGHLAAVEARDAVYLKYLAS 1608
+E+ R + + +++ L Q TS I+T K +A +A ++ +
Sbjct: 1695 ALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRN 1754
Query: 1609 FEEELKRIQDDCTSQIKEAQRWKDS 1633
EE+ K+ D +E ++ +D+
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDT 1779
Score = 50.4 bits (119), Expect = 1e-05
Identities = 128/590 (21%), Positives = 243/590 (41%), Gaps = 91/590 (15%)
Query: 416 KLKSVLKKYAEVIEKTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQ 475
K+K +LK AE EK M+ + R +E + + A RK L + V+L++
Sbjct: 839 KIKPLLKS-AEA-EKEMATMKEDFER--TKEELARSEA---RRKELEEKMVSLLQEKNDL 891
Query: 476 ELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQRR 535
+L + + L+D + + E L++S + + + +E E M ++ V ++R
Sbjct: 892 QLQVQSETENLMDAEE--RCEGLIKS--KILLEAKVKELTERLEEEEEM-NSELVAKKRN 946
Query: 536 LKHLCTIC----DLLPPSYSKTQLTEWHSSLN---SLNKELDTYHVDCMMWIRLLYEKTW 588
L+ C+ D L + +K + E H++ N +L++E+ + +L EK
Sbjct: 947 LEDKCSSLKRDIDDLELTLTKVE-KEKHATENKVKNLSEEMTALEENIS---KLTKEKK- 1001
Query: 589 QECLMHVQNCKKQLLDWKAFTEEEAETLV--NQFFFQMVGALQG---------------- 630
+Q +Q LD E++ L+ N Q L+G
Sbjct: 1002 -----SLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAK 1056
Query: 631 -KVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQH 689
K+E DL++ +S L + + L K E+ QL +A + V L+ +K++++
Sbjct: 1057 RKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQL-QAKIDDEQVHSLQFQKKIKEL 1115
Query: 690 RQK-HSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKE 748
+ + LE +++ H R + +Q+SD LA LE++ + L+ + K
Sbjct: 1116 QARIEELEEEIEAEHTLRAKIE-KQRSD---LARELEEISERLEEASGATSAQIEMNKKR 1171
Query: 749 VMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRK 808
E+ K A Q+ + A V Q + ++ QK K+ +
Sbjct: 1172 EAEFQ----KMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSE 1227
Query: 809 KQGSKEDMTRSEESISSGTS----TARSVE----EVEEENDQE--------MESFITEEV 852
+ +DM + E++S S T R+VE E++ +++Q+ M+ +
Sbjct: 1228 LKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQ 1287
Query: 853 LGQ-----QKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESE 907
G+ ++K L +++ +SK+ Q LEE++ + E E K +S
Sbjct: 1288 NGELSHRVEEKESLISQLTKSKQALTQQLEELKRQME-------EETKAKNAMAHALQSS 1340
Query: 908 EED-----EKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEI 952
D E+ EEE+E K E ++ +A E E D + EE+
Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 1390
Score = 45.4 bits (106), Expect = 4e-04
Identities = 148/759 (19%), Positives = 282/759 (37%), Gaps = 103/759 (13%)
Query: 271 EKERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALASFQEE 330
+K R E+A AA + D++ QR ++ E + + E
Sbjct: 1176 QKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRV----KQKLEKEKSELKME 1231
Query: 331 IAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNL-EDYTIQ-ALLELWDKV 388
I + +E L + T D+ + + K E T L D +Q A L+ +
Sbjct: 1232 IDDMASNIEALSKSKSNIERTCRTVEDQ-FSEIKAKDEQQTQLIHDLNMQKARLQTQN-- 1288
Query: 389 AGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRPEVYR------L 442
G L R +E + L L + + T +L+ LK+ E K M + L
Sbjct: 1289 -GELSHRVEEKESLISQLTKSKQALTQQLEE-LKRQMEEETKAKNAMAHALQSSRHDCDL 1346
Query: 443 INEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQSF 502
+ E+ A ++AL++ + + + E D+ R + L + K+ L Q
Sbjct: 1347 LREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEA-----KKKLAQRL 1401
Query: 503 SEFMASESIHTPPAVTKELEVMLKTQNVLQ------QRRLKHLCTICDLLPPSYSKTQ-- 554
E A E+ T + LE KT+ LQ R L+ T C L
Sbjct: 1402 QE--AEENTETANSKCASLE---KTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKV 1456
Query: 555 LTEWHSSLNSLNKELDTYHVDCMMWIRLLYE--KTWQECLMHVQNCKKQLLDWKA----F 608
L EW L+ EL+ + L++ ++E + ++ +++ + +
Sbjct: 1457 LAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDL 1516
Query: 609 TEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLW 668
TE+ AET N Q + VE++ L + E + E + S + + E+ Q+
Sbjct: 1517 TEQIAETGKN---LQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVK 1573
Query: 669 EAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKE---------- 718
+++ ++ E+E+ ++ V +A + D LR + E
Sbjct: 1574 SELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQL 1633
Query: 719 --------TLAFHLEKVKDYLKNMKSRYECFHTLLTKE--------VMEYPAIMLKELNS 762
HL V+ LK+ S+ L + E V ++L+EL
Sbjct: 1634 GHSNRQMAETQKHLRTVQGQLKD--SQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEE 1691
Query: 763 YSSALSQYFFVREIFEQNL--AGEVIFKFRQPEAHEKPSQKRVK------KLRKKQGSKE 814
AL Q R + EQ L A + + ++K+++ + + +E
Sbjct: 1692 MKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQE 1751
Query: 815 DMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQ 874
E++ + T A EE+++E D ++ L Q K H ++DE+++ +++
Sbjct: 1752 SRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH-RLDEAEQLALK 1810
Query: 875 GLEEM---------QVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEE-------- 917
G ++ ++E E + E +KG + + + +E + EE+
Sbjct: 1811 GGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQD 1870
Query: 918 -----EEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEE 951
+ K++ K + E EEQ + + + LEE
Sbjct: 1871 LVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEE 1909
Score = 37.4 bits (85), Expect = 0.12
Identities = 100/552 (18%), Positives = 212/552 (38%), Gaps = 90/552 (16%)
Query: 252 KWMHSLPNDWIMENPVLHREKERAKREKARESENTIAA-----------REVRGLMDTIV 300
+W D I L K++ + ENT A + ++G ++ ++
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLM 1433
Query: 301 PEKISTSTFQRQAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGL---FLKKLTESD 357
+ + T + K+++++ LA +++++ + E+E ++ L K +
Sbjct: 1434 RDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYE 1493
Query: 358 EEMNRLFLKVENDTNLEDYTIQALLELWDKVA--GRLL--------LRKQEIKELDEALH 407
E +++L + NL++ + +L +++A G+ L L +QE +L AL
Sbjct: 1494 EVVDQLETLRRENKNLQE----EISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALE 1549
Query: 408 SLEFSRTDKLKSVLKKYAEVIEKTSYLMRPEVYRLINEEAMVMNY------------ALL 455
+E S + +L+ E+ + S L R + + E + N A +
Sbjct: 1550 EVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEI 1609
Query: 456 GNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALK------KEALLQSFSEFMASE 509
+R +L + + E+ H + + +T K L+ K++ L ++E
Sbjct: 1610 RSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNE 1669
Query: 510 SIHTPPAVTKE-----LEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNS 564
+ A+ + LE + + + L+Q + +LL S L ++SL +
Sbjct: 1670 DLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLIN 1729
Query: 565 LNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEE------------- 611
K+L+ C + E + QE + KK + D EE
Sbjct: 1730 TKKKLEADIAQCQAEV----ENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 612 -----------------EAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQS 654
EAE L + + + L+ +V E LD + A+ +
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAH 1845
Query: 655 SHLFKYFQEVVQLWEAHQSELLVQEL--ELEKRMEQH-RQKHSLESQ--VQEAHLDRLLD 709
+ K + Q E H++ L +Q+L +L+ +++ + RQ E Q Q + R+
Sbjct: 1846 KYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQH 1905
Query: 710 QLRQQSDKETLA 721
+L + +++ +A
Sbjct: 1906 ELEEAAERADIA 1917
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 69.3 bits (168), Expect = 3e-11
Identities = 278/1516 (18%), Positives = 596/1516 (39%), Gaps = 201/1516 (13%)
Query: 263 MENPVLHREKERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYE- 321
+E + E++R +++ + + + ++ L + + Q + + + +
Sbjct: 769 LEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSE 828
Query: 322 --SALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQ 379
+ + S Q ++ KE E L G ++ ++ EE+++ + E + D Q
Sbjct: 829 QSTLIRSLQSQLQN--KESEVL---EGAERVRHISSKVEELSQALSQKELEITKMD---Q 880
Query: 380 ALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRPEV 439
LLE V +Q I+E D+ + + FS T+K+ + + + + E+
Sbjct: 881 LLLEKKRDVE----TLQQTIEEKDQQVTEISFSMTEKMVQ--------LNEEKFSLGVEI 928
Query: 440 YRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEALL 499
+ + E+ +++ A ++ + + N + S L+Q D + + KE L
Sbjct: 929 -KTLKEQLNLLSRAEEAKKEQVEE--DNEVSSGLKQNYDE-------MSPAGQISKEELQ 978
Query: 500 QSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWH 559
F + + E+ ++L+ L + L QR + + +L S + L+E
Sbjct: 979 HEF-DLLKKENEQRK----RKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETE 1033
Query: 560 SSLNSLNKELDTYHVDCM----MWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAET 615
+KE Y C+ I + ++T E + +Q+ +K L + K EE+ +
Sbjct: 1034 RGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEE-KLAAEEQFQA 1092
Query: 616 LVNQFFFQM------VGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWE 669
LV Q + + LQ ++ E+ ++ K + D ++ S L K V+
Sbjct: 1093 LVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE-TVVISPPC 1151
Query: 670 AHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKD 729
SE ELE EK + ++K L+ ++QEA R + Q + L L++ KD
Sbjct: 1152 TGSSEHWKPELE-EKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKD 1210
Query: 730 YLKNMKSRYECFHT-------------LLTKEVME--YPAIMLKELNSYSSALSQYFF-- 772
++ +++ + +E ++ P+ +E S + L + F
Sbjct: 1211 DYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKA 1270
Query: 773 -----VREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGT 827
+ + E NL + A + + K + K+ E + + S+ +
Sbjct: 1271 TEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTS 1330
Query: 828 STARSVEEVEEENDQ------EMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQV 881
+ EEV + +Q E+ES T + L K+ ES + I GLE ++
Sbjct: 1331 ELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKL-ESSQLQIAGLEHLR- 1388
Query: 882 EREGSLNP-----SLNEENVK---GQGEKKEESEEEDEKEEEEEEEKLEE-----EKEEK 928
E + L+ S EE+V GQ +KE + + + E E+E+ ++ E + K
Sbjct: 1389 ELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAK 1448
Query: 929 EAQEEQESLSVG--------EEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEEHCR 980
E E + L V EE +E ++ +++ IS L+EE
Sbjct: 1449 EHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSL 1508
Query: 981 KSHS----TFSAMFINDTSSAKFIEQVTIPSRLIL--EIKKQLFSEGGN--FSPKEINSL 1032
+ T S + SA+ E+ T+ RL L E + +L +E + ++S
Sbjct: 1509 ARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSS 1568
Query: 1033 CSRLEKEAARIELVESVIMLNMEKLENEYLDQANDVINKFESKFHNLSVDLIFIEKIQRL 1092
C L+ + + ++ +E L++ + ++ + K + ++K +
Sbjct: 1569 CESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKE-----------LQKEYEI 1617
Query: 1093 LTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTWKE 1152
L + + + + Q+L K+++ + ++ E T +E ++ KE
Sbjct: 1618 LLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKE-TEKQLQEAEQEMEEMKE 1676
Query: 1153 KL-------SQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEE---AKL 1202
K+ Q+I L DR+ +T + E +L+S+ +++EE K+
Sbjct: 1677 KMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMET---LLSSNASMKEELERVKM 1733
Query: 1203 DVVTPESFTQLSRVGKPLIEDPAVDVIRKLLQLPNTKWPTHHCDKDPSQTGFKRHRCQP- 1261
+ T Q K + + D+ ++ + + +K +QT Q
Sbjct: 1734 EYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI 1793
Query: 1262 ------ENSGKKAVPSASATSAGSLQTTHPPLSHSFTPHPKPNKM-----ERKYRVLGDK 1310
++S + + S S ++ +P +S F+ H + N + K R+ G +
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853
Query: 1311 PPP--------AAEDFKGIILTLLWESSENLLTVAEEFYRKE------KRPVTRPDCMCD 1356
E+ K +L+ + L + EE + + ++R + +
Sbjct: 1854 EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKE 1913
Query: 1357 TFDQCAENISKKILEYQSQAN-KYHNSCLIELRIQIRRFEELLP------QVCWLVMENF 1409
T ++ +++ ++++ ++ N N C QI+ ELL + C +E
Sbjct: 1914 TAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKN--ELLESEMKNLKKCVSELEEE 1971
Query: 1410 KEHHWKKFFTSVKEIRGQFEEQQKRLEKRKDKNAQKLHLNLGHPVHFQEMESLHLSEEER 1469
K+ K+ EIR ++ E+ + +K + L QE++ L
Sbjct: 1972 KQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRY 2031
Query: 1470 QEELDSMIRMNK--EKLEECTRRNGQVFITNLATFTE----------KFLLQLDEV---- 1513
QE++ ++ R K E ++ ++++ ++ NLA E F + LD+
Sbjct: 2032 QEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEA 2091
Query: 1514 --VTIDDVQVAR-MEPPKQKLSMLIRRKLAGLS--LKEESEKPLIERGSRKWPGIKPTEV 1568
V D++++ + ++ K+ + +++K L L++ EK L E+ + + + +
Sbjct: 2092 ARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQ----EKLDA 2147
Query: 1569 TIQNKILLQPTSSISTTKTTLG----HLAAVEARDAVYLKYLASFEEELKRIQDDCTSQI 1624
+ K+ L+ T I + TL + ++ + LA+F + + +QDD I
Sbjct: 2148 LRREKVHLEET--IGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVI 2205
Query: 1625 KEAQRWKDSWKQSLHT 1640
EA++W+ + ++ +
Sbjct: 2206 DEAKKWERKFSDAIQS 2221
Score = 61.2 bits (147), Expect = 8e-09
Identities = 152/708 (21%), Positives = 280/708 (39%), Gaps = 109/708 (15%)
Query: 606 KAFTEEEAETLVNQFFFQMVGALQGKVE---EDLELLDKSFETL-----ADQTEWQSSH- 656
K TE + L NQ +L+ +E ED E L K E+L A+ TEWQ H
Sbjct: 1550 KLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHK 1609
Query: 657 -LFKYFQEVVQLWE-----AHQSELLVQELELEKR------MEQHRQKHSLESQVQEAH- 703
L K ++ ++Q +E A + + +V+ + EK+ K E Q+QEA
Sbjct: 1610 ELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQ 1669
Query: 704 -LDRLLDQLRQ-QSDKETLAFHLEKVKDYLKNM-----KSRYECFHTLLTKEV------- 749
++ + +++R+ K+ LE+ D L+ + EC TLL+
Sbjct: 1670 EMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELE 1729
Query: 750 ---MEYPAIMLK--ELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVK 804
MEY + K L S +LS+ V+++ Q + G V + + +Q V
Sbjct: 1730 RVKMEYETLSKKFQSLMSEKDSLSEE--VQDLKHQ-IEGNVSKQANLEATEKHDNQTNVT 1786
Query: 805 KLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAK 864
+ + E + S+S+ + + SV + N + F + + + + +
Sbjct: 1787 EEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ-----Q 1841
Query: 865 MDESKEGSIQGLEEMQVEREGSLNPSLNEENV------KGQGEKKEESEEEDEKE---EE 915
+D+ KE I GLEE + + + NE+N GE K EE + ++
Sbjct: 1842 IDQLKE-RIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
Query: 916 EEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEI------YYEDMESFTISSG---- 965
+EE K ++ A+EE++ L EE L E+ Y +D+ I +
Sbjct: 1901 IQEELSRVTKLKETAEEEKDDL----EERLMNQLAELNGSIGNYCQDVTDAQIKNELLES 1956
Query: 966 ---NTYFVFVPLEEEHCR------KSHSTFSAMFINDTSSAKFIEQVTIPSRLILEIKKQ 1016
N LEEE + K S ++ A+ ++ + E+ K+
Sbjct: 1957 EMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKE 2016
Query: 1017 LFSEGGNFSPKEINSLCSR-------LEKEAARIELVESVIMLNMEKLENEYLDQANDVI 1069
E K++ C R LE+ +E V++ ++E + E L QA +
Sbjct: 2017 KQQE-----VKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLE-ITKENLAQAVEHR 2070
Query: 1070 NKFESKFHNLSV--DLIFIEKIQRLLTNLQVKIKCQVAKSNSQTN------GLNFSLQQL 1121
K +++ + V D E + L NL++K + Q K + ++ L L+Q
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQA 2130
Query: 1122 QNKIKTCQESRGEKTT------VTTEELLSFVQTWKEKLSQRIQYLNCSLDRVSMTELVF 1175
+ K +++ EK V EE + +Q K + +Q L +LD F
Sbjct: 2131 EEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAF 2190
Query: 1176 TNTILKDQEEDSDILTSSEALEEEAKLDVVTPESFTQLSRVGKPLIED 1223
T ++ Q++ ++ ++ E + + + E +L +++D
Sbjct: 2191 TKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKD 2238
Score = 58.5 bits (140), Expect = 5e-08
Identities = 180/883 (20%), Positives = 354/883 (40%), Gaps = 130/883 (14%)
Query: 369 NDTNLED------YTIQALLELWDKVAGRLLLRKQEIK--ELDEALHSLEFSRTDKLKSV 420
N+T ED Y Q ++EL D ++R+++++ + DEAL + +K+K +
Sbjct: 43 NNTTQEDVQERLAYAEQLVVELKD------IIRQKDVQLQQKDEALQEERKAADNKIKKL 96
Query: 421 ----------LKKYAEVIEKTSYLMRP----------EVYRLINEEAMVMN---YALLGN 457
L KY E ++ + P + + EE M + + L
Sbjct: 97 KLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEK 156
Query: 458 RKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKAL--KKEALLQSFSEFMASESIHTPP 515
+ ++ L L ++ +Q S + V + L K+E + ++ +++
Sbjct: 157 EELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQ 216
Query: 516 AVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVD 575
V +E + +TQ L + L L T D+ TE L L ++L+ H +
Sbjct: 217 QVVREKDARFETQVRLHEDELLQLVTQADVE---------TEMQQKLRVLQRKLEE-HEE 266
Query: 576 CMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFT-EEEAETLVNQFFFQMVGA--LQGKV 632
++ + + QE Q + Q+L + E E TL N + + L K+
Sbjct: 267 SLVGRAQVVDLLQQELTAAEQ--RNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKM 324
Query: 633 EEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQK 692
E ++ SF L ++ HL + F++ Q + ELE R QK
Sbjct: 325 ELEVAERKLSFHNLQEEMH----HLLEQFEQAGQA-----------QAELESRYSALEQK 369
Query: 693 HSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEY 752
H E + + +H+ L Q++ +E L+ D LK+ S+ + +
Sbjct: 370 HKAEMEEKTSHILSL-----QKTGQE-----LQSACDALKDQNSKLLQDKNEQAVQSAQT 419
Query: 753 PAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGS 812
+ +L S +SQ+ + + A + F E + +++ + L+K+
Sbjct: 420 IQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKR--- 476
Query: 813 KEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGS 872
+ E + ++ +EE++ EN +++ S IT +L Q ++ + +E S
Sbjct: 477 ---VVELENEKGALLLSSIELEELKAEN-EKLSSQIT--LLEAQNRTG-----EADREVS 525
Query: 873 IQGLEEMQVEREGSLNPSLNE--ENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEA 930
+ ++ +R S S + EN Q K+ + KE +EE L+ + + K A
Sbjct: 526 EISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRA 585
Query: 931 QEEQESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMF 990
+E + +E + EG E I M+ F +G F +P EE S+ A+
Sbjct: 586 EEADHEVLDQKEMKQMEG-EGIAPIKMKVFLEDTGQD-FPLMPNEE-------SSLPAVE 636
Query: 991 INDTSS---AKFIEQVTIPSRLILEIKKQLFSEGGNFSPKEINSLCSRLEKEAARIELVE 1047
S+ ++ E++++ + E+K + S C + E E + +++E
Sbjct: 637 KEQASTEHQSRTSEEISLNDAGV-ELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILE 695
Query: 1048 SVIMLNMEKLENEY----------LDQANDVINKFESKF-HNLSVDLIFIEKIQRLLTNL 1096
+ LN K + Y + N +I +F+ +N S E+ +LL+
Sbjct: 696 --LELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLS-- 751
Query: 1097 QVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTWKEKLSQ 1156
QVK V + +Q L +L + + + + ES+ + TE++ S K K
Sbjct: 752 QVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSK-DV 810
Query: 1157 RIQYLNCSLDRVSMTELVFTNTILKD-----QEEDSDILTSSE 1194
+I+ L LD V + + +T+++ Q ++S++L +E
Sbjct: 811 KIEVLQNELDDVQL-QFSEQSTLIRSLQSQLQNKESEVLEGAE 852
Score = 53.5 bits (127), Expect = 2e-06
Identities = 173/885 (19%), Positives = 351/885 (39%), Gaps = 163/885 (18%)
Query: 200 QQIFQAEVQLVHSLAATRKRAAERSVTLKSGRIPMMKKVETPEGEVMSPRQQKWMHSLPN 259
QQI Q + ++ L +++ E S TL++ + ++ ++ T +GE+ +++ +L N
Sbjct: 1840 QQIDQLKERIA-GLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLN 1898
Query: 260 DWIMEN-PVLHREKERAKREKARESENTI-AAREVRGLMDTIVPEKISTSTFQRQAEHKR 317
I E + + KE A+ EK E + E+ G + + E +
Sbjct: 1899 QQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEM 1958
Query: 318 KSYESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYT 377
K+ + ++ +EE Q+ KE + + +L+K+ + +E N ++ ++
Sbjct: 1959 KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPG-------NKSHAKE-- 2009
Query: 378 IQALLELWDKVAGRL---LLRKQE-IKELDEALHSLEFSRTDKLKSV---LKKYAEVIE- 429
+Q LL+ + +L +R QE I L+ + +LEF +T+ K + + A+ +E
Sbjct: 2010 LQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEH 2069
Query: 430 -KTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQLFVN---LMESTLQQELDSRHRWQG 485
K + L+++ L N K +L N + Q++ D R +
Sbjct: 2070 RKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQ 2129
Query: 486 LVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDL 545
+ K LK++ +Q + + E +H + E++V L ++ Q+ ++L +
Sbjct: 2130 AEE--KHLKEKKNMQEKLDALRREKVHLEETIG-EIQVTLNKKDKEVQQLQENLDS---- 2182
Query: 546 LPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLL---YEKTWQECLMHVQNC---K 599
+ TQL + S++SL + D + W R + +E + NC K
Sbjct: 2183 -----TVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLK 2237
Query: 600 KQLLDWKAFTEE-----------------EAETLVNQFFFQMVGALQGKVEE-------- 634
QL EE +A+T V Q ++ LQG+ +E
Sbjct: 2238 DQLRQMSIHMEELKINISRLEHDKQIWESKAQTEV-QLQQKVCDTLQGENKELLSQLEET 2296
Query: 635 ---------DLELLDKSFETLADQTEWQSSHLFKYFQE------VVQLWEA--HQSELLV 677
+L L+ ++L DQ S+ L K ++ +++ EA S+
Sbjct: 2297 RHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSY 2356
Query: 678 QELELEKRMEQ------HRQKHSLESQV------QEAHLDRLLDQLRQQSDKETLAFHLE 725
++LE + + + H + + E ++ +E + + +LRQQ DKE
Sbjct: 2357 EQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKE------- 2409
Query: 726 KVKDYLKNMKSRYECFHTLL----------TKEVMEYPAIMLKELNSYSSALSQYFFVRE 775
+K+ L+N+ S+ E + +L T ++ME + KE + L FV+
Sbjct: 2410 -IKE-LENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDS--FVKS 2465
Query: 776 IFE-QNLAGEVIFKFRQPE------------------AHEKPSQKRVKKLRKKQG--SKE 814
+ QN ++ ++Q E A ++ ++ LR + E
Sbjct: 2466 MSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSE 2525
Query: 815 DMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEG--- 871
+ E I + + + + Q +E + + + K + L K+ ES+E
Sbjct: 2526 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANED 2585
Query: 872 ---SIQGLEEMQVEREGSLNP-------------SLNEENVKG----QGEKKEESEEEDE 911
S L+E + + + +L EE G Q + KEE
Sbjct: 2586 LRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLS 2645
Query: 912 KEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDK-EEGLEEIYYE 955
++++ E +EE +++ + VGE EDK ++ L+ ++++
Sbjct: 2646 ALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHD 2690
Score = 52.4 bits (124), Expect = 4e-06
Identities = 213/1107 (19%), Positives = 440/1107 (39%), Gaps = 169/1107 (15%)
Query: 197 KAYQQIFQAEVQLVHSLAATRKRAAERSVTLKS---GRIPMMKKVETPEGEV--MSPRQQ 251
++Y+ + ++ H + A R+ E L+S + K+++ E E+ M + +
Sbjct: 1620 QSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMR 1679
Query: 252 KWMHSLPNDWIMENPVLHREKERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQR 311
K+ S + +L E+E + +E A + M+T++ S ++ +
Sbjct: 1680 KFAKS------KQQKILELEEENDRLR----AEVHPAGDTAKECMETLLS---SNASMKE 1726
Query: 312 QAEHKRKSYESALASFQEEIAQ---VGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVE 368
+ E + YE+ FQ +++ + +E++ L G K+ E K +
Sbjct: 1727 ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATE------KHD 1780
Query: 369 NDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSL------EFSRTDKLKSVLK 422
N TN+ + Q++ ++ + + E + S +FS D++ + L+
Sbjct: 1781 NQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840
Query: 423 KYAEVIEKTSYLMRPEVYR------LINEEAMVMNYALL--GNRKALAQLF--VNLMEST 472
+ ++ E+ + L + L NE+ +++ G K L + +NL+
Sbjct: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
Query: 473 LQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIH----TPPAVTKEL------- 521
+Q+EL + + + K +E L+ +E S + T + EL
Sbjct: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960
Query: 522 ------EVMLKTQNVLQQR-------RLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKE 568
E+ + Q +++++ R ++L I +K+ E L +E
Sbjct: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQE 2020
Query: 569 LDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGAL 628
+ DC+ + QE + ++ K L F + E++ + + A+
Sbjct: 2021 VKQLQKDCIRY---------QEKISALERTVKAL----EFVQTESQKDLEITKENLAQAV 2067
Query: 629 QGKVEEDLELLDKSFETLADQTEWQSSHLF----KYFQEVVQLWEAHQSELLVQELELEK 684
+ + + EL SF+ L D T+ +++ + K +E+ E+ +S++ ++ +LE+
Sbjct: 2068 EHRKKAQAELA--SFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLER 2125
Query: 685 RMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTL 744
R+EQ +KH E + + LD L + +K L + +++ L +
Sbjct: 2126 RLEQAEEKHLKEKKNMQEKLDAL------RREKVHLEETIGEIQVTLNKKDKEVQQLQEN 2179
Query: 745 LTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVK 804
L V + A K ++S + + +E+ + + + ++ E K V
Sbjct: 2180 LDSTVTQL-AAFTKSMSSLQDDRDRVIDEAKKWERKFSDAI--QSKEEEIRLKEDNCSVL 2236
Query: 805 KLRKKQGS------KEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQ--Q 856
K + +Q S K +++R E S A++ +++++ ++ +E+L Q +
Sbjct: 2237 KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQG-ENKELLSQLEE 2295
Query: 857 KKSPLHAKMDE--SKEGSIQGLEEMQV----------EREGSLNPSLNEENVKGQGEK-K 903
+ H+ +E E ++ L++ E++G+L + ++ Q K
Sbjct: 2296 TRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFS 2355
Query: 904 EESEEEDEKEEEEEEEKLEEEKEEKEAQ------EEQESLSVGEEEDKEEGLEEIYYEDM 957
E E D + E +L EE KE + ++E++ V E +++ +EI +++
Sbjct: 2356 YEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEI--KEL 2413
Query: 958 ESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRLILEIKKQL 1017
E+ V LEEE+ + T M T + I+Q + +
Sbjct: 2414 ENLLSQEEEENIV---LEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQ 2470
Query: 1018 FSEG---GNFSPKEINSLCSRLEKEAARIELVESVIMLNMEKLENEYLDQANDVINKFES 1074
G++ E L LEK+ + E+ N K E L D +N +
Sbjct: 2471 NDRDRIVGDYQQLEERHLSIILEKDQL---IQEAAAENNKLKEEIRGLRSHMDDLNSENA 2527
Query: 1075 KFHNLSVDLI-FIEKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQ---LQNKIKTCQE 1130
K L +LI + E + +++T K + Q L LQQ L+NK +E
Sbjct: 2528 K---LDAELIQYREDLNQVIT----------IKDSQQKQLLEVQLQQNKELENKYAKLEE 2574
Query: 1131 SRGEKTTVTTEELLSF--VQTWKEKLSQRIQYLNCSLDRVS--MTELVFTNTI------L 1180
E + SF +Q K+ LS+ I+ L S+ +++ +T L T+ L
Sbjct: 2575 KLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQL 2634
Query: 1181 KDQEED----SDILTSSE----ALEEE 1199
K +EE+ S + +SS+ LEEE
Sbjct: 2635 KVKEEEVHRLSALFSSSQKRIAELEEE 2661
Score = 46.6 bits (109), Expect = 2e-04
Identities = 200/1030 (19%), Positives = 407/1030 (39%), Gaps = 175/1030 (16%)
Query: 673 SELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQS-DKETLAFHLEKVKDYL 731
+EL Q +LE + + ++ L+ + Q AH + L +Q+ S + ++ +E +++ L
Sbjct: 760 TELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNEL 819
Query: 732 KNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQ 791
+++ ++ TL + S S L QN EV+ +
Sbjct: 820 DDVQLQFSEQSTL---------------IRSLQSQL-----------QNKESEVL----E 849
Query: 792 PEAHEKPSQKRVKKLRKKQGSKE-DMTRSEESISSGTSTARSVEEVEEENDQEME--SFI 848
+ +V++L + KE ++T+ ++ + ++++ EE DQ++ SF
Sbjct: 850 GAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFS 909
Query: 849 TEEVLGQ--QKKSPLHAKMDESKE-----GSIQGLEEMQVEREGSLNPSL----NEENVK 897
E + Q ++K L ++ KE + ++ QVE + ++ L +E +
Sbjct: 910 MTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPA 969
Query: 898 GQGEKKEESEEED--EKEEEEEEEKLE------EEKEEKEAQEEQESLSVGEEEDKEEGL 949
GQ K+E E D +KE E+ + KL+ +E ++ ++ E+E ++ +E KE L
Sbjct: 970 GQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPL 1029
Query: 950 EEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKFIE----QVTI 1005
E ++E N + E C S +++ T S K +E + +
Sbjct: 1030 SETERGEVEE---DKENKEY------SEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDL 1080
Query: 1006 PSRLILEIKKQLFSEGGNFSPKEINSLCSRLEKEAARIE-LVESVIMLNMEKLENEYLDQ 1064
+L E + Q + N + ++ + L+ E + + +++ +I N + + + +
Sbjct: 1081 EEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL 1140
Query: 1065 ANDVI-------NKFESKFHNLSVDLIFIEK----IQRLLTNLQVKIKCQVAKSNSQTNG 1113
+ + E L ++ +EK +Q+ L K + K+ +
Sbjct: 1141 VKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH 1200
Query: 1114 LNFSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTWKEKLSQRIQYLNCSLDRVSMTEL 1173
L L+Q ++ QE E++ E + +++ L ++ + E
Sbjct: 1201 LREELKQQKDDYNRLQEQFDEQSKE------------NENIGDQLRQL-----QIQVRES 1243
Query: 1174 VFTNTILKDQEEDSDILTSSEALEEEAKLDVVTPESFTQLSRVGKPLIEDPAVDVIRKLL 1233
+ DQ+E +S+ LEE L T + TQ P++E
Sbjct: 1244 IDGKLPSTDQQES---CSSTPGLEE--PLFKATEQHHTQ------PVLESNLC------- 1285
Query: 1234 QLPNTKWPTHHCDKDPSQ--TGFKRHRCQPENSGKKAVPSASATSAGSLQTTHPPLSHSF 1291
WP+H D Q T + + Q + + V S+ + + T F
Sbjct: 1286 ----PDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS-EEVF 1340
Query: 1292 TPHPKPNKMERKYRVLGDKPPPAAEDFKGIILTLLWESSENLLTVAEEFYRKEKRPVTRP 1351
+ NK + L A + + L ESS+ L +A + +E +P
Sbjct: 1341 QLQEQINKQGLEIESLKTVSHEAEVHAESLQQKL--ESSQ--LQIAGLEHLRELQP---- 1392
Query: 1352 DCMCDTFDQCAENISKK--ILEYQSQANKYHNSCLIELRIQIRRFEELLPQVCWLVMENF 1409
D+ + ISKK + Y S + L +++ +I E+L+ + +
Sbjct: 1393 -----KLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQA 1447
Query: 1410 KEHHWKKFFTSVKEIRGQFEEQQKRLEKRKDKNAQKLHLNLGHPVHFQEMESLHLSEEER 1469
KEH + +K+++ + E +++ E+ +++ K + +++++ +S +E
Sbjct: 1448 KEHDER-----IKQLQVELCEMKQKPEEIGEESRAKQQIQ-------RKLQAALISRKEA 1495
Query: 1470 QEE---LDSMIRMNKEKLEECTRRNGQVFITNLATFTEK-------FLLQLDEVVTIDDV 1519
+E L + + + +E T+ V A EK LLQ + I ++
Sbjct: 1496 LKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEM 1555
Query: 1520 QVARMEPPKQKLSMLIRR-KLAGLSLKEESEKPLIERGSRKWPGI--------KPTEVTI 1570
+ +E Q LS KLA L E+ EK + E S K I K E+
Sbjct: 1556 DRSLLE--NQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQK 1613
Query: 1571 QNKILLQPTSSISTTKTTLGHL--AAVEARDAVYLKYLASFEEELKRIQDDCTSQIKEAQ 1628
+ +ILLQ ++S + H+ A + + +Y K L S E K + Q++EA+
Sbjct: 1614 EYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGK-LRSTEANKKETE----KQLQEAE 1668
Query: 1629 RWKDSWKQSL 1638
+ + K+ +
Sbjct: 1669 QEMEEMKEKM 1678
Score = 38.5 bits (88), Expect = 0.054
Identities = 83/449 (18%), Positives = 174/449 (38%), Gaps = 63/449 (14%)
Query: 820 EESISSGTSTARSVEE---VEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGL 876
E + +T V+E E+ E++ I ++ + Q+K + ++ + I+ L
Sbjct: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKL 96
Query: 877 EEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEE---EEKLEEEKEEKEAQEE 933
+ + SLN + E +G E + E++ + ++ EE++E EK + + QE+
Sbjct: 97 KLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEK 156
Query: 934 QESLSVGEEEDKEEGLEEIYYE--DMESFTISSGNTY--FVFVPLEEEHCRKSHSTFSAM 989
+E +S + + + E+ +ME F + F+ + ++ + +A
Sbjct: 157 EELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQ 216
Query: 990 FINDTSSAKFIEQVTIPSRLILEIKKQLFSEGGNFSPKEI---------NSLCSR----- 1035
+ A+F QV + +L++ Q E + SL R
Sbjct: 217 QVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVD 276
Query: 1036 -LEKEAARIELVESVIMLNMEKLENEYLDQANDV-INKFESK----------------FH 1077
L++E E ++ ++++E E+ N V + ESK FH
Sbjct: 277 LLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFH 336
Query: 1078 NLSVDLIFI-----------EKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIK 1126
NL ++ + +++ + L+ K K ++ + S L + Q+LQ+
Sbjct: 337 NLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQS--- 393
Query: 1127 TCQESRGEKTTVTTEELLSFVQTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEED 1186
C + + + + ++ VQ+ +Q IQ L L + S F N + Q E
Sbjct: 394 ACDALKDQNSKLLQDKNEQAVQS-----AQTIQQLEDQLQQKSKEISQFLNRLPLQQHET 448
Query: 1187 SDILTSSEALEEEAKLDVVTPESFTQLSR 1215
+ + + E + VT E+ L +
Sbjct: 449 ASQTSFPDVYNEGTQ--AVTEENIASLQK 475
Score = 35.8 bits (81), Expect = 0.35
Identities = 71/371 (19%), Positives = 146/371 (39%), Gaps = 72/371 (19%)
Query: 611 EEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEA 670
EE V + + VG ++ K++++L+ L + ++TE + + +++V++
Sbjct: 2659 EEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEM--- 2715
Query: 671 HQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDY 730
Q L+V ++ L +Q+Q R + L+ D +
Sbjct: 2716 EQKLLMVT-----------KENKGLTAQIQS--FGRSMSSLQNSRDH---------ANEE 2753
Query: 731 LKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFR 790
L +K +Y+ LKEL + Q RE L E F
Sbjct: 2754 LDELKRKYDA---------------SLKEL---AQLKEQGLLNRE--RDALLSETAFSMN 2793
Query: 791 QPEAHEKPSQKRVKKLRKKQGSKEDM-----TRSEESISSGTSTARSVEEVEEENDQ--- 842
E + S ++KL ++ SK++ ++ E+S + S ++++ ++ E D
Sbjct: 2794 STEEN---SLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWN 2850
Query: 843 EMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNP---------SLNE 893
E+E F E G+Q+ + + + + + +Q +R+ L +N+
Sbjct: 2851 ELEKFRKSEE-GKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
Query: 894 ENVKGQGEKKEESEEEDEK------EEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEE 947
E + K + E +D+ +EE +E L + E + + E+ S + E KE+
Sbjct: 2910 EITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQ 2969
Query: 948 GLEEIYYEDME 958
L I +D +
Sbjct: 2970 YLMAISDKDQQ 2980
Score = 35.0 bits (79), Expect = 0.60
Identities = 77/387 (19%), Positives = 155/387 (40%), Gaps = 48/387 (12%)
Query: 199 YQQIFQAEVQLVHSLAATRKRAAERSVTLKSGRIPMMKKVETPEGEVMSPRQQKWMHSLP 258
Y + + + VH L+A + +R L+ + + K+ GE+ +++ H
Sbjct: 2630 YHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHH 2689
Query: 259 NDWIMENPVLHREK---ERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEH 315
+ IM N E+ E A+ E + + +E +GL I S S+ Q +H
Sbjct: 2690 DAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDH 2749
Query: 316 K-------RKSYESALASFQE--EIAQVGKEMEPLIVDTGGLFLKKLTESD-----EEMN 361
++ Y+++L + E + +E + L+ +T F TE + E++N
Sbjct: 2750 ANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETA--FSMNSTEENSLSHLEKLN 2807
Query: 362 RLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVL 421
+ L + + LL L + +L +++ +A+ SL+ R D L + L
Sbjct: 2808 QQLLSKD----------EQLLHL----SSQLEDSYNQVQSFSKAMASLQNER-DHLWNEL 2852
Query: 422 KKYAEVIE-KTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQ--QELD 478
+K+ + E K +P + +L +R L + NL + LQ QE+
Sbjct: 2853 EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEIT 2912
Query: 479 SRH-------RWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVL 531
H +Q ++ +++E ++ S + + + E +K Q ++
Sbjct: 2913 ELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLM 2972
Query: 532 ----QQRRLKHLCTICDLLPPSYSKTQ 554
+ ++L HL + L S S+TQ
Sbjct: 2973 AISDKDQQLSHLQNLIRELRSSSSQTQ 2999
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 67.8 bits (164), Expect = 8e-11
Identities = 284/1487 (19%), Positives = 580/1487 (39%), Gaps = 236/1487 (15%)
Query: 187 VGKVTQVPNGKAYQQIFQAEVQLV---HSLAATRKRAAERSVTLKS----GRIPMMKKVE 239
+GK+ ++ N Y F + H L+ R + SV +S + + ++E
Sbjct: 425 LGKINKMKNSN-YADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIE 483
Query: 240 -TPEGEVMSPRQ-QKWMHSLPNDWIMENPVLHREKERAKRE------KARESENTIAARE 291
P ++++ + ++SL D+ +N VL E+ R ++E K + + A E
Sbjct: 484 WNPATKLLNQENIESELNSLRADY--DNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALE 541
Query: 292 VRGLMDT---IVPEKISTSTFQRQAEHKRKSYESALASFQEEIAQVGKEMEPL--IVDTG 346
+ D ++ E + + AE + E+ L+S E + + +++ L +D+
Sbjct: 542 RKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS- 600
Query: 347 GLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEAL 406
+KL +++ +E+ ++ A D LR + + EL E +
Sbjct: 601 ----QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENL-ELKEKM 655
Query: 407 HSLE--FSRTDKLKSVLKKYAEVIEKTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQL 464
L + + + + + E +K + E+ NE + L + K L
Sbjct: 656 KELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNE---ITKLTSLIDGKVPKDL 712
Query: 465 FVNL----MESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAV--- 517
NL + LQ+EL+ V+ +AL++E +L S + + SE +
Sbjct: 713 LCNLELEGKITDLQKELNKE------VEENEALREEVILLSELKSLPSEVERLRKEIQDK 766
Query: 518 TKELEVMLKTQNVLQQRRLKHLCTICDLLPP-SYSKTQLTEWHSSLNSLNKELD---TYH 573
++EL ++ ++ L + + LL +K L S+ S ++E T H
Sbjct: 767 SEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLH 826
Query: 574 VDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVE 633
+D +++ E+ + + N K+ + + L + ++ LQ K
Sbjct: 827 MDFEQKYKMVLEEN-ERMNQEIVNLSKEAQKF----DSSLGALKTELSYK-TQELQEKTR 880
Query: 634 EDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKH 693
E E L++ E L +Q E + S L + V+ + +E L Q LE K + Q +K
Sbjct: 881 EVQERLNE-MEQLKEQLENRDSTL-----QTVEREKTLITEKLQQTLEEVKTLTQ--EKD 932
Query: 694 SLESQVQEAHLDRLLDQLRQQSDKETLAFHL---EKVKDYLKNMKSRYECFHTLLTKEVM 750
L+ + ++R DQL+ +T+ ++ E++++ L+++K E +TL +K
Sbjct: 933 DLKQLQESLQIER--DQLKSDIH-DTVNMNIDTQEQLRNALESLKQHQETINTLKSKISE 989
Query: 751 EYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPS----------- 799
E + E N+ + ++ F+Q + G I K + EA +
Sbjct: 990 EVSRNLHMEENTGET--------KDEFQQKMVG--IDKKQDLEAKNTQTLTADVKDNEII 1039
Query: 800 --QKRVKKLRKKQGSKEDMTRS--EESISSGTSTARSVEEVEEENDQEMESFITE----- 850
Q+++ L +++ + M S E T ++E + EN +E+ E
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIE-MTIENQEELRLLGDELKKQQ 1098
Query: 851 EVLGQQKKSPLH------------AKMDESKEGSIQGLEEMQV------EREGSLNPSLN 892
E++ Q+K + A+++E + Q L+E Q E + +N
Sbjct: 1099 EIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKIN 1158
Query: 893 E-ENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEE-KEAQEEQESL-----SVGEEEDK 945
E EN+K + + KE + E E E E +KL E EE K +E++ L S E D
Sbjct: 1159 EIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDH 1218
Query: 946 EEGLEEIYYEDMESFTISSGNTY-FVFVPLEE-----EHCRKSHSTFSAMFIN----DTS 995
G Y ++E+ + + + L+E + R+S S +A IN + S
Sbjct: 1219 LRG----YIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKS 1274
Query: 996 SAKFIEQVTIPSRLILEIKKQLFSEGGNFSPKEINSLCSRLEKEAARIELVESVIMLNME 1055
K E++ +L +++L S + L E + + ++ + ME
Sbjct: 1275 HTKLQEEIP-----VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEME 1329
Query: 1056 KLE-NEYLDQANDVINKFESKFHNLSVDLIFI--------EKIQRLLTNLQVKIKCQ--- 1103
+L NE ++ + I + NL + E I+ L +Q Q
Sbjct: 1330 RLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQS 1389
Query: 1104 --VAKSNSQTNGLNFSLQQLQNK--------------IKTCQESRGEKTTVTTEE----- 1142
+ + +++T + ++Q + K K QES E +V E+
Sbjct: 1390 LNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQR 1449
Query: 1143 LLSFVQTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEEEAKL 1202
L +Q+ ++L + I+ + + + EL + LK+QEE + +L
Sbjct: 1450 LQEVLQSESDQLKENIKEI-VAKHLETEEELKVAHCCLKEQEETIN------------EL 1496
Query: 1203 DVVTPESFTQLSRVGKPL--IEDPAVDVIRKLLQLP---NTKWPTHHCDKDPSQTGFKRH 1257
V E T++S + K L I D + I+++ + N K + +K FK H
Sbjct: 1497 RVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEH 1556
Query: 1258 RCQPENSGKKAVPSASATSAGSLQTTHPPLSHSFTPHPKPNKMERKYRVLGDKPPPAAED 1317
R + ++S +++ S LQ + + + +++ ++ D+
Sbjct: 1557 R-KAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQ------- 1608
Query: 1318 FKGIILTLLWESSENLLTVAEEFYRKEKRPVTRPDCMCDTFDQCAENISKKILEYQSQAN 1377
L E+++ ++ +E KE + + +K+ E +
Sbjct: 1609 --------LKENTKEIVAKMKESQEKEYQFLKM---------TAVNETQEKMCEIEHLKE 1651
Query: 1378 KYHNSCLIELRIQIRRFEELLPQVCWLVMENFKEHHWKKFFTSVKEIRGQFEEQQKRLEK 1437
++ ++ + E ++ ++ EN +E SV + R ++ L+
Sbjct: 1652 QFETQ-----KLNLENIETENIRLTQILHENLEE------MRSVTKERDDLRSVEETLKV 1700
Query: 1438 RKDKNAQKLHLNLGHPVHFQ-EMESLHLSEEERQEELDSMIRMNKEKLEECTRRNGQVFI 1496
+D+ + L + + Q E++ +H+ +E QE +D + + EK E + +
Sbjct: 1701 ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEH 1760
Query: 1497 TNLATFTEKFLLQLDEVVTIDDVQVARMEPPKQKLSMLIRRKLAGLS 1543
+N A + L++ E + I + + + KL ++ K LS
Sbjct: 1761 SNDALKAQD--LKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLS 1805
Score = 63.9 bits (154), Expect = 1e-09
Identities = 208/1102 (18%), Positives = 422/1102 (38%), Gaps = 211/1102 (19%)
Query: 264 ENPVLHREKERAKREK-ARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYES 322
E PVLH E+E K E++ T+ E+ T ST + E +R
Sbjct: 1281 EIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTT-----KDSTTLARIEMERLRLNE 1335
Query: 323 ALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQALL 382
QEEI + KE + L L +K + E + K++ + ++ ++ +
Sbjct: 1336 KFQESQEEIKSLTKERDNLKTIKEALEVKH-DQLKEHIRETLAKIQESQSKQEQSLN--M 1392
Query: 383 ELWDKVAGRLLLRKQEIKELDEALHSLEFSRT----------DKLKSV------LKKYAE 426
+ D +++ ++ K D AL +E D++KSV L++ E
Sbjct: 1393 KEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQE 1452
Query: 427 VIEKTSYLMRPEVYRLI------NEEAMVMNYALLGNRKALAQLFVNLME-----STLQQ 475
V++ S ++ + ++ EE V + L + + +L VNL E ST+Q+
Sbjct: 1453 VLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQK 1512
Query: 476 ELDSRH-----------------------RWQGLVDTWKALK-----KEALLQSFSEFMA 507
+L++ + Q V+ K K K++ LQS M
Sbjct: 1513 QLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKML 1572
Query: 508 SESIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNK 567
E + +E+++M+K + + +R++ I + QL E + + K
Sbjct: 1573 -ELTNRLQESQEEIQIMIKEKE--EMKRVQEALQI--------ERDQLKENTKEIVAKMK 1621
Query: 568 ELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEE-EAETL-VNQFFFQMV 625
E ++++ QE + +++ K+Q K E E E + + Q + +
Sbjct: 1622 ESQEKEYQ---FLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENL 1678
Query: 626 GALQG--KVEEDLELLDKSFETLADQT----------------EWQSSHL-FKYFQEVVQ 666
++ K +DL ++++ + DQ E + H+ K QE +
Sbjct: 1679 EEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETID 1738
Query: 667 LWEAHQSELLVQELELEKRMEQHR-----QKHSLESQVQEAHLDRLLDQLRQQSDKETLA 721
SE + ++K +E Q ++ +++ AH+ QQ + L
Sbjct: 1739 KLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLK----EQQETIDKLR 1794
Query: 722 FHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPA------IMLKELNSYSSALSQYFFVR- 774
+ + D L NM+ E + L +++ E A + K++N +S+ ++
Sbjct: 1795 GIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK 1854
Query: 775 EIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTAR-SV 833
+I +Q+L + + +K + +++++ ++++ R EE++ + S+
Sbjct: 1855 QIKDQSLTLSKL-EIENLNLAQK-LHENLEEMKSVMKERDNLRRVEETLKLERDQLKESL 1912
Query: 834 EEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNE 893
+E + + + + T +L ++ K + ++ E +IQ + ++Q + L+ S +E
Sbjct: 1913 QETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ-ISDIQKD----LDKSKDE 1967
Query: 894 ENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIY 953
K Q +K+E + KE+ K E E+ + Q E ++LS+ L +
Sbjct: 1968 LQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKL 2027
Query: 954 YEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRLILEI 1013
+E +E I V E + R+ S D A E + R ++
Sbjct: 2028 HESLEEIRI---------VAKERDELRRIKE--SLKMERDQFIATLREMIA-RDRQNHQV 2075
Query: 1014 K--KQLFSEGGNFSPKEINSLCSRLEKEAAR---------------------IELVESVI 1050
K K+L S+G + + CSR+++ R IE + +
Sbjct: 2076 KPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELS 2135
Query: 1051 M-----LNMEKLENEYLDQANDVINKFESKFHNLSVDLIF-------------------- 1085
M L++ L+ +++++ + +FH + L +
Sbjct: 2136 MRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFE 2195
Query: 1086 ------IEKIQRLLTNLQ-VKIKCQVAKSNSQTNGLNFSLQ-QLQNKIKTCQESRGEKTT 1137
+EK + LL +Q ++ C V + LN ++ ++ +K ES E +
Sbjct: 2196 MDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSES--EFPS 2253
Query: 1138 VTTE---------ELLSFVQTWK------EKLSQRIQYLNCSLDRVSMTELVFTNTILKD 1182
+ TE E+ F++ W EKL IQ N DR+ F N I+
Sbjct: 2254 IKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKEN---DRICQVNNFFNNRIIAI 2310
Query: 1183 QEEDSDILTSSEALEEEAKLDV 1204
E ++ S + +E + D+
Sbjct: 2311 MNESTEFEERSATISKEWEQDL 2332
Score = 53.5 bits (127), Expect = 2e-06
Identities = 183/955 (19%), Positives = 365/955 (38%), Gaps = 143/955 (14%)
Query: 254 MHSLPNDWIMENPVLHREKERAK-----REKARESENTIAAREVRGLMDTIVPEKISTST 308
+ ++ + I +LH E + R+ R E T+ D + T T
Sbjct: 1660 LENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVER-----DQLKENLRETIT 1714
Query: 309 FQRQAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVE 368
+ + + K L QE I ++ + + + K L S++ + LK++
Sbjct: 1715 RDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNM-QKDLEHSNDALKAQDLKIQ 1773
Query: 369 NDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSV-------- 420
+ + ++ E DK+ G + + ++ + + L + +K++ +
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833
Query: 421 -LKKYAEVIEKTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQLFVNLME-STLQQELD 478
LKK +K M ++ + I ++++ ++ + N +L NL E ++ +E D
Sbjct: 1834 TLKKDVNETQKKVSEME-QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD 1892
Query: 479 SRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQRRLKH 538
+ R V+ L+++ L +S E A + E++ LKT +L + +H
Sbjct: 1893 NLRR----VEETLKLERDQLKESLQETKARD---------LEIQQELKTARMLSK---EH 1936
Query: 539 LCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNC 598
T+ L + +++E ++ + K+LD + I+ L +K Q L+ V
Sbjct: 1937 KETVDKL------REKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQ--LLRV--- 1985
Query: 599 KKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLF 658
K+ ++ E E L QF Q + ++Q ++ +L K E+L + +
Sbjct: 1986 -KEDVNMSHKKINEMEQLKKQFEAQNL-SMQSVRMDNFQLTKKLHESLE-----EIRIVA 2038
Query: 659 KYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKE 718
K E+ ++ E+ + E L + + + RQ H ++ + RLL QQ E
Sbjct: 2039 KERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPE------KRLLSD-GQQHLTE 2091
Query: 719 TLAFHLEKVKDYLK---NMKSRYECFHTL---LTKEVMEYPAIMLKELNSYSSALSQYFF 772
+L ++K+ LK M YEC + L L KE+ + ++ + S Q
Sbjct: 2092 SLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKH 2151
Query: 773 VREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARS 832
+ ++F N + F + +KKL+
Sbjct: 2152 IEKLFTANQRCSMEF------------HRIMKKLK--------------------YVLSY 2179
Query: 833 VEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLN 892
V +++EE + + F + + +K+ L K+ ++ E++ + + + N L+
Sbjct: 2180 VTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELR-DLKLNQNMDLH 2238
Query: 893 EENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEI 952
E + K+ SE E + E ++ L KE + EE + E+ K G+++
Sbjct: 2239 IEEI-----LKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLK-NGIQK- 2291
Query: 953 YYEDMESFTISSGNTYF----VFVPLEEEHCRKSHSTFSAMFINDTSSAKFIEQVTIPSR 1008
E+ I N +F + + E + +T S + D S K + +
Sbjct: 2292 -----ENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNY 2346
Query: 1009 LILEIKKQLFSEGGNFSP-------KEINSLCSRLEKEAARIELVESVIMLNMEKLENE- 1060
L K + G +P + S ++L E R EL S+ + E
Sbjct: 2347 QTL---KTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIR-ELENSLHEAKESAMHKES 2402
Query: 1061 -------YLDQANDVINKFESKFHNLSVDLIFIEKIQRLLTNLQVKIKCQVAKSNSQTNG 1113
L+ ND+I K ++K H + L EK + + LQ K+ +
Sbjct: 2403 KIIKMQKELEVTNDIIAKLQAKVHESNKCL---EKTKETIQVLQDKVALGAKPYKEEIED 2459
Query: 1114 LNFSLQQLQ-NKIKTCQESRGE--KTTVTTEELLSFVQTWKEKLSQRIQYLNCSL 1165
L L ++ K+K +E E T T E ++ +E L + Q + S+
Sbjct: 2460 LKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSV 2514
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 67.4 bits (163), Expect = 1e-10
Identities = 76/336 (22%), Positives = 151/336 (44%), Gaps = 16/336 (4%)
Query: 629 QGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQ 688
+GK+ E E + + + L +Q + L + +E+ + E + E +QE E EK EQ
Sbjct: 306 EGKMREQEEKMWRQEKRLREQEK----ELREQEKELREQKELREQEEQMQEQE-EKMWEQ 360
Query: 689 HRQKHSLESQV--QEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLT 746
+ E ++ QE L Q+R+Q K + E++ + + ++ + E
Sbjct: 361 EEKMREQEEKMWRQEERLWEQEKQMREQEQK--MRDQEERMWEQDERLREKEERMRE--Q 416
Query: 747 KEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKL 806
+++ E M +E ++ E+ E K R+ E + +++++K
Sbjct: 417 EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ 476
Query: 807 RKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQ--EMESFIT--EEVLGQQKKSPLH 862
+ +E+ ++ + E+++E+ ++ E E I EE+ GQ+KK
Sbjct: 477 EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 536
Query: 863 AKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLE 922
KM E ++ + E+M+ + + + E + EKK +EE +EEE E+ +
Sbjct: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596
Query: 923 EEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDME 958
+ +EE+E EQE + E+E+K + EE +E E
Sbjct: 597 KMREEEEMMREQEE-KMQEQEEKMQEQEEKMWEQEE 631
Score = 63.9 bits (154), Expect = 1e-09
Identities = 87/399 (21%), Positives = 174/399 (43%), Gaps = 44/399 (11%)
Query: 585 EKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFE 644
EK +E ++ +K+L + K E+E + + + + + K+ E E + + E
Sbjct: 320 EKRLREQEKELREQEKELREQKELREQEEQMQEQE---EKMWEQEEKMREQEEKMWRQEE 376
Query: 645 TLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHL 704
L +Q + K + ++WE Q+ L ++ E+ R++ + QV++
Sbjct: 377 RLWEQEKQMREQEQKMRDQEERMWE--------QDERLREKEERMREQEKMWEQVEKMRE 428
Query: 705 DRLL-DQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSY 763
++ + +Q ++ D+E E++++ K M+ E K + +E N +
Sbjct: 429 EKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEK-------MQKQEENMW 481
Query: 764 SSALSQYFFVR------EIFEQNLAGEVIFKFRQPEAHEKPSQ------KRVKKLRKKQG 811
++ R +++EQ E K + E + + K++ + K +
Sbjct: 482 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE 541
Query: 812 SKEDMTRSEESISSGTSTARSVEEVEEENDQEME--SFITEEVLGQQKKSPLHAKMDESK 869
++ M EE + EE E+ QE E ++ EE + ++++ K +
Sbjct: 542 QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 601
Query: 870 EGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEE---EEEEKLEEEK- 925
E ++ EE E+E + EE + Q EK +E EE+ ++EE E+EEK+ E++
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQ--EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQR 659
Query: 926 --EEKEAQEEQESLSVGEEEDKEEGLEEIY-YEDMESFT 961
E+KE E E + E+E +E E+I+ E ME T
Sbjct: 660 LPEQKEKLWEHEKMQ--EQEKMQEQEEKIWEQEKMEKKT 696
Score = 63.2 bits (152), Expect = 2e-09
Identities = 92/402 (22%), Positives = 172/402 (42%), Gaps = 64/402 (15%)
Query: 629 QGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVV-----QLWEAHQSELLVQELEL- 682
Q K++E E + + E + DQ E + QE + Q+WE + ++ QE ++
Sbjct: 503 QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWE-QEEKMRDQEQKMW 561
Query: 683 --EKRMEQHRQKHSLESQVQEAHL---DRLLD-QLRQQSDKETLAFHLEKVKDYLKNMKS 736
E+RME+ Q+ ++ QE + +R+ + + + + ++E + EK+++ + M+
Sbjct: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621
Query: 737 RYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVR------------EIFEQNLAGE 784
+ E K + + +E + + R ++ EQ E
Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
Query: 785 VIFKFRQPEAHEKPSQKRVKKL--RKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQ 842
K + E EK +Q++ KK ++K +E M E+ + R EE +E ++
Sbjct: 682 QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE 741
Query: 843 EMES------------FITEEVLGQQKKSPL-------HAKMDESKEGSIQGLEEMQVER 883
+M+ + EE + +Q++ P H KM E ++ I EE ++
Sbjct: 742 KMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK--IWEQEEKMRDQ 799
Query: 884 EGSLNPSLNEENVKGQGEKKEESEEEDEKEEEE----------EEEKL--EEEKEEKEAQ 931
E + EE ++GQ EK EE+ +EE+ +EEK+ +EEK E++ Q
Sbjct: 800 EEKMRGQ--EEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQ 857
Query: 932 EEQESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVP 973
++E + E+E+K G EE E E Y V P
Sbjct: 858 GQEEKMR--EQEEKMRGQEEKMREQEEKMRGQEEKIYCVGSP 897
Score = 60.5 bits (145), Expect = 1e-08
Identities = 134/707 (18%), Positives = 277/707 (39%), Gaps = 116/707 (16%)
Query: 261 WIMENPVLHREKE-RAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKS 319
W E + +EK+ R + EK E + RE G M R+ E K
Sbjct: 275 WRQEEELREQEKKIRKQEEKMWRQEERL--REQEGKM--------------REQEEKMWR 318
Query: 320 YESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMN----RLFLKVENDTNLED 375
E L ++E+ + KE+ K+L E +E+M +++ + E E+
Sbjct: 319 QEKRLREQEKELREQEKELREQ---------KELREQEEQMQEQEEKMWEQEEKMREQEE 369
Query: 376 YTIQALLELWDKVAGRLLLRKQEIK---------ELDEALHSLEFSRTDKLKSVLKKYAE 426
+ LW++ +R+QE K E DE L E ++ K + + E
Sbjct: 370 KMWRQEERLWEQ---EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK--MWEQVE 424
Query: 427 VIEKTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGL 486
+ + + E EE M + K + + + E + + + W+
Sbjct: 425 KMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQE 484
Query: 487 VDTWKALK----KEALLQSFSEFMASESIHTPPAVTKELEVML-KTQNVLQQRRLKHLCT 541
W+ + KE L + E I ++ E M + + + +Q +++
Sbjct: 485 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE--- 541
Query: 542 ICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQ 601
+ Q+ E + +++ + +KTW + +++
Sbjct: 542 ---------QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQ--------EEK 584
Query: 602 LLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYF 661
+ + + E E + + +M+ + K++E E + + E + +Q E K +
Sbjct: 585 MREEERMREREKKMREEE---EMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMW 641
Query: 662 QEVVQLWEAHQSELLVQELELEKRM----EQHRQKHSLESQVQEAHLDRLLDQLRQQSDK 717
++ ++WE + Q L +K E+ +++ ++ Q ++ +++ Q+ +K
Sbjct: 642 EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEK 701
Query: 718 ETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIF 777
+T + EK+++ ++M+ R + +E+M ++E + E++
Sbjct: 702 KT--WDQEKMREE-ESMREREKKMRE--EEEMMREQEEKMQEQEEKMQEQEE-----EMW 751
Query: 778 EQNLAGEVIFKFRQPEAHEKP-SQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEV 836
EQ + + E EK Q+R+ + ++K E M E + E+
Sbjct: 752 EQ--------EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE----------KIWEQE 793
Query: 837 EEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENV 896
E+ DQE E++ GQ++K + +E + G EE +E + EE +
Sbjct: 794 EKMRDQE------EKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ--EEKM 845
Query: 897 KGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEE 943
GQ EK EE + E++ E+EEK+ ++E+ QEE+ G+EE
Sbjct: 846 WGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMR---GQEE 889
Score = 59.7 bits (143), Expect = 2e-08
Identities = 80/381 (20%), Positives = 170/381 (44%), Gaps = 52/381 (13%)
Query: 585 EKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFE 644
EK W++ + +K++ + + T ++ E + + + + + K+ E+ E + + E
Sbjct: 417 EKMWEQ--VEKMREEKKMQEQEKKTRDQEEKMQEE---ERIREREKKMREEEETMREQEE 471
Query: 645 TLADQTE---------WQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSL 695
+ Q E WQ L ++ +LWE Q ++ QE ++ ++ E+ R + +
Sbjct: 472 KMQKQEENMWEQEEKEWQQQRLP---EQKEKLWE--QEKMQEQEEKIWEQEEKIRDQEEM 526
Query: 696 ESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAI 755
Q ++ +++R+Q D+ + EK++D + M + E + K+ E
Sbjct: 527 WGQEKKMWRQ---EKMREQEDQ--MWEQEEKMRDQEQKMWDQEE----RMEKKTQE---- 573
Query: 756 MLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKED 815
+E ++ E+ + E + R+ + E+ R ++ K Q +E
Sbjct: 574 --QEKKTWDQ------------EEKMREEERMREREKKMREEEEMMREQE-EKMQEQEEK 618
Query: 816 MTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQG 875
M EE + + EE E +++M + EE + +Q++ P K + +Q
Sbjct: 619 MQEQEEKMWEQEEKMQEQEEKMWEQEEKM--WEQEEKMWEQQRLP-EQKEKLWEHEKMQE 675
Query: 876 LEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQE 935
E+MQ + E E+ K Q ++K+ ++E +EEE E+ ++ +EE+E EQE
Sbjct: 676 QEKMQEQEEKIWEQEKMEK--KTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Query: 936 SLSVGEEEDKEEGLEEIYYED 956
+EE +E EE++ ++
Sbjct: 734 EKMQEQEEKMQEQEEEMWEQE 754
Score = 47.0 bits (110), Expect = 2e-04
Identities = 55/218 (25%), Positives = 101/218 (46%), Gaps = 31/218 (14%)
Query: 757 LKELNSYSSALSQYFFVREIFEQNLA---GEVIFKFRQPEAHEKPSQKRVKKLRKKQGSK 813
++EL ALS + I + L E+ K E+ + Q VK+L++K
Sbjct: 199 IEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERA 258
Query: 814 EDMTRSEESISSGTSTARSVEEVEEEND----QEMESFITEEVLGQQKKSPLHAKMDESK 869
+ + ++ + R EE+ E+ QE + + EE L +Q+ KM E +
Sbjct: 259 KFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQE-----GKMREQE 313
Query: 870 EGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEE--EEEEKLEEEKE- 926
E + E+ E+E L E+ ++ Q E +E+ E+ E+EE+ E+EEK+ E++E
Sbjct: 314 E-KMWRQEKRLREQEKELREQ--EKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEK 370
Query: 927 -----------EKEAQEEQESLSVGEEE--DKEEGLEE 951
EK+ +E+++ + EE +++E L E
Sbjct: 371 MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLRE 408
Score = 44.7 bits (104), Expect = 8e-04
Identities = 38/166 (22%), Positives = 76/166 (45%), Gaps = 10/166 (6%)
Query: 793 EAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEV 852
E +K + + +KL + K ++ + + + A+ + + N + E + EE
Sbjct: 221 EELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE 280
Query: 853 LGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEK 912
L +Q+K +E + EE E+EG + E+ K ++K E+E E
Sbjct: 281 LREQEKKI------RKQEEKMWRQEERLREQEGKMR----EQEEKMWRQEKRLREQEKEL 330
Query: 913 EEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDME 958
E+E+E + ++E E+E Q +++ + E+E+K EE + E
Sbjct: 331 REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEE 376
Score = 31.6 bits (70), Expect = 6.6
Identities = 37/165 (22%), Positives = 71/165 (43%), Gaps = 23/165 (13%)
Query: 1326 LWESSENLLTVAEEFYRKEKRPVTRPDCMCDTFDQCAENISKKILEYQSQANKYHNSCLI 1385
+WE E + E+ +R+E+R ++Q +K + Q Q + +
Sbjct: 357 MWEQEEKMREQEEKMWRQEER----------LWEQ------EKQMREQEQKMRDQEERMW 400
Query: 1386 ELRIQIRRFEELL--PQVCWLVMENFKEHHWKKFFTSVKEIRGQFE--EQQKRLEKRKDK 1441
E ++R EE + + W +E +E KK K+ R Q E ++++R+ +R+ K
Sbjct: 401 EQDERLREKEERMREQEKMWEQVEKMREE--KKMQEQEKKTRDQEEKMQEEERIREREKK 458
Query: 1442 NAQKLHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEKLEE 1486
++ Q+ E ++ E+E +E + KEKL E
Sbjct: 459 MREEEETMREQEEKMQKQEE-NMWEQEEKEWQQQRLPEQKEKLWE 502
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 67.4 bits (163), Expect = 1e-10
Identities = 80/363 (22%), Positives = 154/363 (42%), Gaps = 67/363 (18%)
Query: 639 LDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQE----LELEKRMEQHRQKHS 694
L+K + L +Q + ++ + Q+ + WE Q EL QE LELEKR+E+ R+
Sbjct: 378 LEKRRQALMEQQQREAE---RKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELER 434
Query: 695 LESQVQEAHLDR-----------------------LLDQ--------LRQQSDKETLAFH 723
+ + ++R LL+Q +R S K+ L
Sbjct: 435 QREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLE 494
Query: 724 LEK--------------VKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQ 769
LE V+ + K+ E E+ME + +EL Y + L
Sbjct: 495 LEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQ-QELQEYQNKL-- 551
Query: 770 YFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTR--SEESISSGT 827
+ + E+ L E I + V L KK KE++ + E+ +
Sbjct: 552 ---IYLVPEKQLLNERIKNMQ----FSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEK 604
Query: 828 STARSVEEVEEENDQEME---SFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVERE 884
TA + E++ N+Q E ++ T+++ +Q K+ E + ++ +++ ++E E
Sbjct: 605 ETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDE 664
Query: 885 GSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEED 944
+ +EN+ + +KEE E++ +EE+ +EK++EE+ + E ++ ++ ++ EE
Sbjct: 665 AARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEK 724
Query: 945 KEE 947
K E
Sbjct: 725 KRE 727
Score = 43.1 bits (100), Expect = 0.002
Identities = 103/457 (22%), Positives = 187/457 (40%), Gaps = 95/457 (20%)
Query: 818 RSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLE 877
R + I S T S ++++EE Q KK P+ + D+ K +G
Sbjct: 332 RGGKQIDSINGTLPSYQKMQEEEPQ--------------KKLPVTFE-DKRKANYERGNM 376
Query: 878 EMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESL 937
E++ R+ + E K Q EK+E ++ E +E+E +++LE EK E+Q L
Sbjct: 377 ELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKR----LEKQREL 432
Query: 938 SVGEEEDKEEGLE--EIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTS 995
EE++ + +E E +++E LE E R+ + +
Sbjct: 433 ERQREEERRKDIERREAAKQELERQR-----------RLEWERIRRQE-------LLNQK 474
Query: 996 SAKFIEQVTIPSRLILEIKKQLFSEGGNFSPKEINSLCSRLEKEAARIELVESVIMLNME 1055
+ + E V + S+ KK L E+ +L + ++ + R++ V + +
Sbjct: 475 NREQEEIVRLNSK-----KKNLH--------LELEALNGKHQQISGRLQDVR--LKKQTQ 519
Query: 1056 KLENEYLDQANDVINKFESKFHNLSVDLIFIEKIQRLLTNLQVKIKCQVAKSNSQTNGLN 1115
K E E LD+ D ++++ I+++Q+ L Q K+ V +
Sbjct: 520 KTELEVLDKQCD-------------LEIMEIKQLQQELQEYQNKLIYLVPEK-------- 558
Query: 1116 FSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTWKEKLSQRIQYLNCSLDRVS---MTE 1172
Q L +IK Q S + V+ LL KE+L QR++ +L++ + ++E
Sbjct: 559 ---QLLNERIKNMQFSNTPDSGVS---LLHKKSLEKEELCQRLKEQLDALEKETASKLSE 612
Query: 1173 LVFTNTILKDQEEDSDILTSSEALEE--EAKLDVVTPESFTQLSRVGKPLIEDPAVDVIR 1230
+ N LK+ E + T ALE+ + K D + +L + K +ED A R
Sbjct: 613 MDSFNNQLKELRETYN--TQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAA---R 667
Query: 1231 KLLQLPNTKWPTHHCDKDPSQTGFKRHRCQPENSGKK 1267
K Q W + ++ K+ R Q E + +K
Sbjct: 668 KAKQGKENLWKENLRKEEEE----KQKRLQEEKTQEK 700
Score = 35.8 bits (81), Expect = 0.35
Identities = 51/226 (22%), Positives = 99/226 (43%), Gaps = 19/226 (8%)
Query: 1410 KEHHWKKFFTSVKEIRGQFE-EQQKRLEKRKD---KNAQKLHLNLGHPVHFQEMESLHLS 1465
+E WKK K + Q E E+Q+ E+RKD + A K L + ++ + L
Sbjct: 412 QEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELL 471
Query: 1466 EEERQEELDSMIRMNKEKLE---ECTRRNG--QVFITNLATFTEKFLLQLDEVVTID--- 1517
++ +E+ + ++R+N +K E NG Q L K Q E+ +D
Sbjct: 472 NQKNREQ-EEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQC 530
Query: 1518 DVQVARMEPPKQKLSMLIRRKLAGLSLKEESEKPLIERGSRKWPGIKPTEVTIQNKILLQ 1577
D+++ ++ +Q+L + KL L +++ I+ + ++ + V++ +K L+
Sbjct: 531 DLEIMEIKQLQQELQE-YQNKLIYLVPEKQLLNERIK--NMQFSNTPDSGVSLLHKKSLE 587
Query: 1578 PTSSISTTKTTLGHLAAVEARDAVYLKYLASFEEELKRIQDDCTSQ 1623
K L A+E A L + SF +LK +++ +Q
Sbjct: 588 KEELCQRLKE---QLDALEKETASKLSEMDSFNNQLKELRETYNTQ 630
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 66.2 bits (160), Expect = 2e-10
Identities = 217/1025 (21%), Positives = 399/1025 (38%), Gaps = 156/1025 (15%)
Query: 270 REKERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQ---AEHKRKSYESALAS 326
R +E +R + ++E + ++ L + + E+ + Q + E K K E
Sbjct: 923 RVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQII 982
Query: 327 FQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLF-LKVENDTNLEDYTIQALLELW 385
+++ ++ KE + L+ D F LTE +E+ L LK +++ + D
Sbjct: 983 LEDQNCKLAKEKK-LLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITD---------- 1031
Query: 386 DKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRPE-----VY 440
+ RL +++ +EL++ LE TD + + A++ E L + E
Sbjct: 1032 --LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAAL 1089
Query: 441 RLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSRHRWQ----GLVDTWKALKKE 496
+ EEA N AL R+ +Q ++ ++ L+ E SR++ + L + +ALK E
Sbjct: 1090 ARVEEEAAQKNMALKKIRELESQ--ISELQEDLESERASRNKAEKQKRDLGEELEALKTE 1147
Query: 497 ALLQSFSEFMASESIHTPPA-----VTKELEVMLKTQNV-LQQRRLKHLCTICDLLPPSY 550
L + A + + + + K LE KT +Q+ R KH + +L +
Sbjct: 1148 -LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEEL---AE 1203
Query: 551 SKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYE-KTWQECLMHVQNCKKQLLDWKAFT 609
Q ++L + L+ + +++L + K E + Q L K F
Sbjct: 1204 QLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVK-FN 1262
Query: 610 EEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWE 669
E E V V LQ +++ LL +S + T+ S L Q+ +L +
Sbjct: 1263 EGER---VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTK-DFSALESQLQDTQELLQ 1318
Query: 670 AHQSELL-----VQELELEKRM------EQHRQKHSLESQVQEAHLD------RLLDQL- 711
+ L ++++E EK E+ KH+LE Q+ H ++ D +
Sbjct: 1319 EENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVG 1378
Query: 712 ----------RQQSDKETLAF-HLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKEL 760
+ Q D E L+ H EKV Y K K++ T L +E+ + +L +L
Sbjct: 1379 CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTK-----TRLQQELDD----LLVDL 1429
Query: 761 NSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPS----QKRVKKLRKKQGSKEDM 816
+ + ++ F+Q LA E + E ++ +K K L + +E M
Sbjct: 1430 DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAM 1489
Query: 817 --------------TRSEESISSGTSTARSVEEVEEEN---DQEMESFITE-EVLGQQKK 858
T E+ +SS +SV E+E+ +Q++E T+ E L + +
Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ 1549
Query: 859 SPLHAK---------MDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESE-- 907
+ AK M E +QG +E E++ L + E + + E+K+ S
Sbjct: 1550 ATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAV 1609
Query: 908 ------EEDEKEEEEEEEKLEEEKEE--KEAQEEQESLS--VGEEEDKEEGLEEIYYEDM 957
E D K+ E + + ++E K+ ++ Q + + E +D EEI +
Sbjct: 1610 AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK 1669
Query: 958 ESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRLILEIKKQL 1017
E+ + + L+EE + A D A I + L LE K++L
Sbjct: 1670 EN-EKKLKSMEAEMIQLQEELAAAERAKRQAQQERD-ELADEIANSSGKGALALEEKRRL 1727
Query: 1018 FSEGGNFSPKEINSLCSRLEKEAARIELVESVIMLNMEKLENEYLDQANDVINKFES--- 1074
I L LE+E EL+ + K N +DQ N +N S
Sbjct: 1728 --------EARIAQLEEELEEEQGNTELINDRL-----KKANLQIDQINTDLNLERSHAQ 1774
Query: 1075 KFHNLSVDLIFIEKIQRLLTNLQVKIK----CQVAKSNSQTNGLNFSLQQLQNKI--KTC 1128
K N ++++R L+VK++ +K + L + QL+ ++ +T
Sbjct: 1775 KNENAR------QQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETK 1828
Query: 1129 QESRGEKTTVTTEELLSFVQTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSD 1188
+ K TE+ L V + + + D+ S T L L++ EE++
Sbjct: 1829 ERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAS-TRLKQLKRQLEEAEEEAQ 1887
Query: 1189 ILTSS 1193
+S
Sbjct: 1888 RANAS 1892
Score = 55.8 bits (133), Expect = 3e-07
Identities = 131/618 (21%), Positives = 262/618 (42%), Gaps = 81/618 (13%)
Query: 636 LELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELEL----EKRMEQHRQ 691
+++L ++ WQ LF + ++Q+ + E++ +E EL EK++ +
Sbjct: 809 MKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQV-SRQEEEMMAKEEELVKVREKQLAAENR 867
Query: 692 KHSLESQVQEAHLDRLLDQLRQQSDKET-LAFHLEKVKDYLKNMKSRYE-CFHTLLTKEV 749
+E+ + ++L QL++Q ET L E+++ L K E H L +
Sbjct: 868 LTEMETLQSQLMAEKL--QLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEAR-- 923
Query: 750 MEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEK-PSQKRVKKLRK 808
+E + L + + Q ++E+ EQ E RQ EK ++ ++KKL +
Sbjct: 924 VEEEEERCQHLQAEKKKMQQN--IQELEEQLEEEE---SARQKLQLEKVTTEAKLKKLEE 978
Query: 809 KQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDES 868
+Q ED +++ E+ E + +TEE ++KS AK+
Sbjct: 979 EQIILEDQN----------CKLAKEKKLLEDRIAEFTTNLTEE----EEKSKSLAKLKNK 1024
Query: 869 KEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEK 928
E I LEE ++ RE L + K +G+ + S++ E + + E K++ K+E+
Sbjct: 1025 HEAMITDLEE-RLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083
Query: 929 EAQ-------EE--QESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEE-H 978
E Q EE Q+++++ + + E + E+ ED+ES S L EE
Sbjct: 1084 ELQAALARVEEEAAQKNMALKKIRELESQISELQ-EDLESERASRNKAEKQKRDLGEELE 1142
Query: 979 CRKSH--STFSAMFINDTSSAKFIEQVTIPSRLILEIKKQLFSEGGNFSPKEINSLCSRL 1036
K+ T + +K ++V I + + E K ++ K ++
Sbjct: 1143 ALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAV---- 1198
Query: 1037 EKEAARIELVESVIMLNMEK----LENEYLDQANDVI-------------NKFESKFHNL 1079
E+ A ++E + V N+EK LENE + AN+V K E++ L
Sbjct: 1199 EELAEQLEQTKRV-KANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL 1257
Query: 1080 SVDLIFIEKIQRLLTNLQVKIKCQV-----------AKSNSQTNGLNFSLQQLQNKIKTC 1128
V E+++ L + K++ ++ +KS+ T + QLQ+ +
Sbjct: 1258 QVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELL 1317
Query: 1129 QESRGEKTTVTT--EELLSFVQTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEED 1186
QE +K +++T +++ +++E+L + + +L++ T + K E+
Sbjct: 1318 QEENRQKLSLSTKLKQVEDEKNSFREQLEEE-EEAKHNLEKQIATLHAQVADMKKKMEDS 1376
Query: 1187 SDILTSSEALEEEAKLDV 1204
L ++E ++ + + D+
Sbjct: 1377 VGCLETAEEVKRKLQKDL 1394
Score = 37.7 bits (86), Expect = 0.093
Identities = 159/806 (19%), Positives = 318/806 (39%), Gaps = 123/806 (15%)
Query: 212 SLAATRKRAAERSVTLKSGRIPMMKKVETPEGEVMSPRQQKWMHSLPNDWIMENPVLHRE 271
S AA ++ ++R + + + ++ +T E ++ RQ+ HS + + E + +
Sbjct: 1154 STAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQK---HSQAVEELAEQ-LEQTK 1209
Query: 272 KERAKREKAR---ESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALASFQ 328
+ +A EKA+ E+E A EV+ L+ + +EHKRK E+ L Q
Sbjct: 1210 RVKANLEKAKQTLENERGELANEVKVLLQG-----------KGDSEHKRKKVEAQLQELQ 1258
Query: 329 ----------EEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTI 378
E+A +++ + + GL L++SD + ++L D + + +
Sbjct: 1259 VKFNEGERVRTELADKVTKLQVELDNVTGL----LSQSDSKSSKL----TKDFSALESQL 1310
Query: 379 QALLELWDKVAGRLLLRKQEIKELDEALHSL--EFSRTDKLKSVLKKYAEVIEKTSYLMR 436
Q EL + + L ++K++++ +S + ++ K L+K + M+
Sbjct: 1311 QDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMK 1370
Query: 437 PEVYRLIN--EEAMVMNYALLGNRKALAQLF---------VNLMESTLQQELDSR----- 480
++ + E A + L + + L+Q + ++ LQQELD
Sbjct: 1371 KKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLD 1430
Query: 481 HRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQRRLKHLC 540
H+ Q + K KK F + +A E + K E + + +++ K L
Sbjct: 1431 HQRQSACNLEKKQKK------FDQLLAEEKTIS----AKYAEERDRAEAEAREKETKALS 1480
Query: 541 TICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKK 600
L + E + L LNK+ T D +M + K+ E + ++
Sbjct: 1481 LARAL-------EEAMEQKAELERLNKQFRTEMED-LMSSKDDVGKSVHELEKSKRALEQ 1532
Query: 601 QLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKY 660
Q+ + K EE + L Q + ++E +L+ + FE + QS K
Sbjct: 1533 QVEEMKTQLEELEDEL------QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQ 1586
Query: 661 FQEVVQLWEAHQSELLVQELELEKRMEQH----RQKHSLESQVQEAHLDRLLDQLRQQSD 716
V+ EA ELE E++ R+K ++ + EAH+D ++ R ++
Sbjct: 1587 LVRQVREMEA--------ELEDERKQRSMAVAARKKLEMDLKDLEAHIDSA-NKNRDEAI 1637
Query: 717 KETLAFHLEKVKDYLKNMKSRYECFHTLLTK--------EVMEYPAIMLKE-LNSYSSAL 767
K+ + +KD ++ + +L + + ME I L+E L + A
Sbjct: 1638 KQLRKLQAQ-MKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAK 1696
Query: 768 SQYFFVREIFEQNLA---GEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKE---DMTRSE- 820
Q R+ +A G+ + E + ++L ++QG+ E D +
Sbjct: 1697 RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN 1756
Query: 821 ---ESISSGTSTARSVEEVEEENDQEMESFITE-EVLGQQKKSPLHAKMDES---KEGSI 873
+ I++ + RS + E Q++E E +V Q+ + + +K S E I
Sbjct: 1757 LQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKI 1816
Query: 874 QGLEEM----QVEREGSLNPSLNEE----NVKGQGEKKEESEEEDEKEEEEEEEKLEEEK 925
LEE ER+ + E +V Q + + + E+ + + ++ +L++ K
Sbjct: 1817 AQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLK 1876
Query: 926 EEKEAQEEQESLSVGEEEDKEEGLEE 951
+ E EE+ + + LE+
Sbjct: 1877 RQLEEAEEEAQRANASRRKLQRELED 1902
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 65.9 bits (159), Expect = 3e-10
Identities = 67/318 (21%), Positives = 123/318 (38%), Gaps = 25/318 (7%)
Query: 672 QSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYL 731
+ EL +E+ R +R++ S+E + +E D L + QQ ++ H
Sbjct: 50 EGELRDHCMEITIRNSPYRREDSMEDRGEED--DSLAIKPPQQMSRKEKVHHR------- 100
Query: 732 KNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQ 791
K+ K + +C H + E ++ + +E + R +E+ E+ + +
Sbjct: 101 KDEKRKEKCRHHSHSAEGGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSR 160
Query: 792 PEAHE----KPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESF 847
E + ++R +K+R++Q + + E + EV + E +
Sbjct: 161 RERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDY 220
Query: 848 ITEEVLGQQKKSPLHAKMD------------ESKEGSIQGLEEMQVEREGSLNPSLNEEN 895
+ +SP + E K L ++Q + S E +
Sbjct: 221 SDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESS 280
Query: 896 VKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYE 955
G EE EEE+E+EEEE E E+EE+E +EE+E EE E+ EE+ E
Sbjct: 281 SAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE 340
Query: 956 DMESFTISSGNTYFVFVP 973
+M + + VP
Sbjct: 341 EMSEDEERENENHLLVVP 358
Score = 51.6 bits (122), Expect = 6e-06
Identities = 52/189 (27%), Positives = 81/189 (42%), Gaps = 7/189 (3%)
Query: 790 RQPEAHEKPSQKRVK-KLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFI 848
R+ AH + ++ K++ S+ E G EE EE D + S +
Sbjct: 207 REVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERD--LLSDL 264
Query: 849 TEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVERE-GSLNPSLNEENVKGQGEKKEESE 907
+ ++K S + ES GS + EE + E E GS + EE + + E++E
Sbjct: 265 QDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGS 324
Query: 908 EEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEE--DKEEGLEEIYYEDM-ESFTISS 964
+E E+ EE EEE E E +E + L V E D++ G E E++ E SS
Sbjct: 325 NSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSS 384
Query: 965 GNTYFVFVP 973
T +VP
Sbjct: 385 ALTEGDYVP 393
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 65.9 bits (159), Expect = 3e-10
Identities = 68/287 (23%), Positives = 132/287 (45%), Gaps = 24/287 (8%)
Query: 678 QELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQ--QSDKETLAFHLEKVKDYLKN-- 733
Q+L E+ E+H QKH E + +E L R ++ R + ++ET E+ K LK
Sbjct: 423 QQLRREQEEERHEQKH--EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQ 480
Query: 734 MKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVR----EIFEQNLAGEVIFKF 789
+ R E + L +E E ++L + R E +Q L E +
Sbjct: 481 EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRR 540
Query: 790 RQPEAHE----KPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEME 845
Q E E + +KR+++ R++Q K + + + R + ++ E ++ +E
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQ-QRLKREQEERLE 599
Query: 846 SFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEE 905
+ E + + ++ +E +E ++ EE + ER L S +E + Q ++E+
Sbjct: 600 QRLKREEVERLEQ-------EERREQRLKR-EEPEEERRQQLLKSEEQEERRQQQLRREQ 651
Query: 906 SEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEI 952
E +++ + EEEE+ E++ ++E +EE+ + EEE +E+ E I
Sbjct: 652 QERREQRLKREEEEERLEQRLKREHEEERREQELAEEE-QEQARERI 697
Score = 65.5 bits (158), Expect = 4e-10
Identities = 72/293 (24%), Positives = 131/293 (44%), Gaps = 37/293 (12%)
Query: 666 QLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLE 725
QL + + EL +E E +R EQ RQ E QE ++LL + R++ ++ E
Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE--EQLLREEREKRRRQ------E 955
Query: 726 KVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEV 785
+ + Y K+ K + + LL +E E +Y RE E E
Sbjct: 956 RERQYRKDKKLQQK-EEQLLGEE---------PEKRRRQEREKKY---REEEELQQEEEQ 1002
Query: 786 IFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEME 845
+ + + + + +++ +K + Q +E + R E R E EE +E
Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE-- 1060
Query: 846 SFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEE 905
E++LG+++++ + + E + EE+Q E E L EE K + +++E
Sbjct: 1061 ----EQLLGEERET----RRRQELERQYRKEEELQQEEE----QLLREEPEKRRRQERER 1108
Query: 906 SEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDME 958
E+E+ ++EEE+ L EE+E++ QE + EE +EE E++ E+ E
Sbjct: 1109 QCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE--EQLLREEPE 1159
Score = 63.9 bits (154), Expect = 1e-09
Identities = 77/336 (22%), Positives = 145/336 (43%), Gaps = 32/336 (9%)
Query: 626 GALQGKVEEDLELLDKSF---ETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELEL 682
G Q + +E LE D+ E + EWQ + +E +Q + H++E E +L
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210
Query: 683 EKR--MEQHRQKHSLESQVQEAHLDRLLDQLRQQS--DKETLAFHLEKVKDYLKNMKSRY 738
+R +E R+ + Q + DR+ + ++ +ET+ L K ++ L+ + +
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETV---LRKEEEKLQEEEPQR 267
Query: 739 ECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAH-EK 797
+ L +E + + +EL Q +Q L E + +Q E E+
Sbjct: 268 Q---RELQEEEEQLRKLERQELRRERQEEEQQ-------QQRLRREQQLRRKQEEERREQ 317
Query: 798 PSQKRVKKLRKKQGS--KEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQ 855
++R ++ R++Q +E R E+ R E+ EE +Q++ EE Q
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQLRR--EQEEERREQQLRREQEEERREQ 375
Query: 856 QKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEE 915
Q + + ++ Q E Q+ RE L E+ ++ + + + E + E+EEE
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLR---REQQLRREQQLRREQQLRREQEEE 432
Query: 916 EEEEKLEEEKEEKEAQEEQES----LSVGEEEDKEE 947
E+K E+E+ E+ + EQE L EE ++ E
Sbjct: 433 RHEQKHEQERREQRLKREQEERRDWLKREEETERHE 468
Score = 62.8 bits (151), Expect = 3e-09
Identities = 146/711 (20%), Positives = 277/711 (38%), Gaps = 85/711 (11%)
Query: 267 VLHREKERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALAS 326
+L RE+ER ++ RE E + R R ++ + E+ +R+ + + + +
Sbjct: 578 LLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE 637
Query: 327 FQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQALLELWD 386
QEE Q ++L +E LK E + +
Sbjct: 638 EQEERRQ-----------------QQLRREQQERREQRLKREEEE--------------E 666
Query: 387 KVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRPEVYRLINEE 446
++ RL +E + E + +++KS + K+ +E + + +VY ++
Sbjct: 667 RLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQ 726
Query: 447 AMVMNYALLGNRKALAQLFVNLM-ESTLQ-QELDSRHRWQGLVDTWKALKKEALLQSFSE 504
G R+ Q ES LQ QE + HR Q + + + + SE
Sbjct: 727 E--------GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778
Query: 505 FMASESIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNS 564
+ + P + ++ E L+ + QQR + L + + Q E L
Sbjct: 779 -RGRQRLSARPPLREQRERQLRAEE-RQQREQRFLP---EEEEKEQRRRQRREREKELQF 833
Query: 565 LNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQM 624
L +E + ++ + ++ +++ W+ EEE + + + +
Sbjct: 834 LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893
Query: 625 VGALQGKVEEDLELLDKSFETLA--DQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELEL 682
ALQ ++ ++ +LL + E L ++ + + + ++E QL + + +LL +E E
Sbjct: 894 --ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQL-QQEEEQLLREEREK 950
Query: 683 EKRMEQHRQ--KHSLESQVQEAHLDRLLDQLRQQS------DKETLAFHLEKVKDYLKNM 734
+R E+ RQ K Q +E L ++ R+Q ++E L E++ +
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREK 1010
Query: 735 KSRYECFHTLLTKEVMEYPAIML----KELNSYSSALSQYFFVREIF--EQNLAGEVIFK 788
+ R E K+ ++ L +E QY E+ E+ L GE
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET 1070
Query: 789 FRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFI 848
R+ E +++ +K + Q +E + R E R E EEE QE E +
Sbjct: 1071 RRRQEL-----ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCRE-EEELQQEEEQLL 1124
Query: 849 TEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEE 908
EE ++K+ + +E EE+Q E E L EE K + ++ E
Sbjct: 1125 REE---REKRRRQELERQYREE------EEVQQEEE----QLLREEPEKRRRQELERQYR 1171
Query: 909 EDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDMES 959
E+E E ++EEE+L E++EK QE + EE +++ + ED S
Sbjct: 1172 EEE-ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS 1221
Score = 62.0 bits (149), Expect = 5e-09
Identities = 72/342 (21%), Positives = 135/342 (39%), Gaps = 53/342 (15%)
Query: 617 VNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELL 676
V Q + +G G EE D L D+ + + F E +L
Sbjct: 81 VAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRF----------EPRDRQLE 130
Query: 677 VQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKS 736
+ + ++ Q +++ E + Q +RL + RQ+ D+E + + + ++
Sbjct: 131 EEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEE--LWRQRQEWQEREERRA 188
Query: 737 RYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHE 796
E + E E+P E+ L + + R+ E
Sbjct: 189 EEEQLQSCKGHETEEFPD-----------------------EEQLRRRELLELRRKGREE 225
Query: 797 KPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEE--VEEENDQEMESFITEEVLG 854
K Q+R ++ R Q +E R E++ R EE EEE ++ E EE L
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETV------LRKEEEKLQEEEPQRQRELQEEEEQLR 279
Query: 855 QQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEE 914
+ ++ L + E ++ ++ ++ RE L EE + Q E++E+ E +++EE
Sbjct: 280 KLERQELRRERQEEEQ------QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEE 333
Query: 915 EEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYED 956
E++ E++E +E Q +E EEE +E+ L E+
Sbjct: 334 RREQQLRREQEERREQQLRREQ----EEERREQQLRREQEEE 371
Score = 58.2 bits (139), Expect = 7e-08
Identities = 97/503 (19%), Positives = 204/503 (40%), Gaps = 43/503 (8%)
Query: 470 ESTLQQELDSRHRWQGLVDTWKALKK----------EALLQSFSEFMASESIHTPPAVTK 519
+S Q+ L+ R R + + W+ ++ E LQS E +
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Query: 520 EL-EVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMM 578
EL E+ K + QQ+R + + + + + EW L KE +
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRV-------FQEEEEKEWRKRETVLRKEEE-------- 258
Query: 579 WIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDLEL 638
+L E+ ++ + + + + L+ + E E Q + L+ K EE+
Sbjct: 259 --KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR- 315
Query: 639 LDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQ 698
+ E +Q E + + Q++ + E + + L +E E E+R +Q R++ E +
Sbjct: 316 --EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373
Query: 699 VQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLK 758
Q+ ++ L + +Q ++ L + ++ + + L ++ + +
Sbjct: 374 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 759 ELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTR 818
+ + RE E+ + + + + E HE+ +K+ K +++ +E +
Sbjct: 434 HEQKHEQERREQRLKREQEERR---DWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 819 SEESISSGTSTARSVE---EVEEENDQEMESFITEEVLGQQKKSP--LHAKMDESKEGSI 873
EE R + E EE +Q ++ EE L Q+ +S L + +E +E +
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Query: 874 QGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEE----EKEEKE 929
+ EE ++E+E E+ + K E E ++ + E+EE+LE+ E+ E+
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610
Query: 930 AQEEQESLSVGEEEDKEEGLEEI 952
QEE+ + EE +EE +++
Sbjct: 611 EQEERREQRLKREEPEEERRQQL 633
Score = 56.2 bits (134), Expect = 3e-07
Identities = 70/346 (20%), Positives = 143/346 (41%), Gaps = 40/346 (11%)
Query: 606 KAFTEEEAETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVV 665
+ F E+E + + Q+ K ED +LL + E + E K+ +E
Sbjct: 1595 RKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDR----KFLEEEP 1650
Query: 666 QLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLE 725
QL + + L + + + R E+ + E Q++ DR + QQ ++ E
Sbjct: 1651 QLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ------E 1704
Query: 726 KVKDYLKNMKS--RYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAG 783
+ + +L+ + R E +E L++ Q + + + E+ L
Sbjct: 1705 RERKFLQEEQQLRRQELERKFREEE-------QLRQETEQEQLRRQERYRKILEEEQLRP 1757
Query: 784 EVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQE 843
E E + Q+R +K R+++ +++ R E+ + S S + EE + ++E
Sbjct: 1758 E-------REEQQLRRQERDRKFREEEQLRQE--REEQQLRSQESDRKFREEEQLRQERE 1808
Query: 844 MESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKK 903
+ ++ G+ + +++E +E ++ +E E+ + ++
Sbjct: 1809 EQQLRPQQRDGKYRWEEEQLQLEE---------QEQRLRQERDRQYRAEEQFATQEKSRR 1859
Query: 904 EESE---EEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKE 946
EE E EE++K +E E KL EE ++ +EEQ VGE + +E
Sbjct: 1860 EEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQE 1905
Score = 54.7 bits (130), Expect = 7e-07
Identities = 155/748 (20%), Positives = 284/748 (37%), Gaps = 86/748 (11%)
Query: 264 ENPVLHREKE---RAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSY 320
E +L E+E R +REK R E RE L + + +R+ + + + Y
Sbjct: 902 EQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE-EEQLLREEREKRRRQERERQY 960
Query: 321 ESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQA 380
Q+E +G+E E KK E +E L+ E + L + +
Sbjct: 961 RKDKKLQQKEEQLLGEEPEKRRRQERE---KKYREEEE------LQQEEEQLLREEREKR 1011
Query: 381 LLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRPEVY 440
+ W+ R +K E+++ +E L E + +L+ ++Y E E ++ E
Sbjct: 1012 RRQEWE----RQYRKKDELQQEEEQLLREEREKR-RLQERERQYREEEE-----LQQEEE 1061
Query: 441 RLINEEAMVMNYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQ 500
+L+ EE L + + E L++E + R R + + ++E LQ
Sbjct: 1062 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE----RERQCREEEELQ 1117
Query: 501 SFSEFMASESIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHS 560
E + E +ELE + + +QQ + L P + +L +
Sbjct: 1118 QEEEQLLREE--REKRRRQELERQYREEEEVQQEEEQLLREE----PEKRRRQELERQYR 1171
Query: 561 SLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQL---------LDWKAFTEE 611
L +E + + R E+ ++E + +KQ L W+ E+
Sbjct: 1172 EEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEK 1231
Query: 612 EAETLVNQFFFQMVGALQGKVEEDLELLDKSFET-----LADQTE---------WQSSHL 657
E N+ + + Q + ED +L D+ + L +Q E WQ
Sbjct: 1232 ENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRD- 1290
Query: 658 FKYFQEVVQLWEAHQSE-------------LLVQELELEKRMEQHRQKHSLESQV-QEAH 703
++F E QL Q E LL +E E ++R ++ +K E Q+ QE
Sbjct: 1291 -RHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349
Query: 704 LDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKS--RYECFHTLLTKEVMEYPAIMLKELN 761
L Q R + +E H E+ + +L+ + R E L +E + +E
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ----LRCQERE 1405
Query: 762 SYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEE 821
F RE +Q E KFR+ E + ++ K L ++Q +++ R
Sbjct: 1406 QQLRQDRDRKF-REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK-- 1462
Query: 822 SISSGTSTARSVEEVEEENDQEMESFITEE--VLGQQKKSPLHAKMDESKEGSIQGLEE- 878
+ EE + + F+ EE + Q++ + S+E + LEE
Sbjct: 1463 -FREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEE 1521
Query: 879 MQVEREGSLNPSLNEEN-VKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESL 937
Q+ R+ L EE ++ Q ++ ++ D K EEE+ + E E+++ QE
Sbjct: 1522 QQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKF 1581
Query: 938 SVGEEEDKEEGLEEIYYEDMESFTISSG 965
+ E++ + + E + ED + G
Sbjct: 1582 RLEEQKVRRQEQERKFMEDEQQLRRQEG 1609
Score = 52.0 bits (123), Expect = 5e-06
Identities = 69/299 (23%), Positives = 131/299 (43%), Gaps = 28/299 (9%)
Query: 669 EAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVK 728
E + +LL +E E ++ + Q+ LE +++ ++RL + R++ + E+ +
Sbjct: 572 EERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631
Query: 729 DYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFK 788
LK+ + + E L +E E LK E EQ L E +
Sbjct: 632 QLLKS-EEQEERRQQQLRREQQERREQRLKREEE-----------EERLEQRLKREHEEE 679
Query: 789 FRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESI--SSGTSTARSVEEVEEENDQEMES 846
R+ E E+ ++ ++++ + + SE S S R E +QE +
Sbjct: 680 RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKR 739
Query: 847 FITEEVLGQQKKSPLHAKMDESKEG-----SIQGLEEMQVEREG-SLNPSLNEENVKG-Q 899
E L Q++ H + E ++ Q E+ + R+ S P L E+ + +
Sbjct: 740 RRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLR 799
Query: 900 GEKKEESEEEDEKEEEEEEEKLEEEKE-EKEAQ--EEQESLSVGEE----EDKEEGLEE 951
E++++ E+ EEEE+E++ + +E EKE Q EE+E L E +++E+GL+E
Sbjct: 800 AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858
Score = 51.6 bits (122), Expect = 6e-06
Identities = 76/368 (20%), Positives = 154/368 (41%), Gaps = 26/368 (7%)
Query: 606 KAFTEEEAETLVNQF--FFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQE 663
+ F EEE + + F + LQ + E+ L ++ + L ++ + + + F+E
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE 1505
Query: 664 VVQLWEAHQSELLVQELELEKRMEQH----------RQKHSLESQVQEAHLDRLLDQLRQ 713
+ + + L +E +L ++ Q RQ+ + + R +QLRQ
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565
Query: 714 QSDKETLA-------FHLEKVKDYLKNMKSRY-ECFHTLLTKEVMEYPAIMLKELNSYSS 765
+ +++ L+ F LE+ K + + ++ E L +E +
Sbjct: 1566 EREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE 1625
Query: 766 ALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISS 825
L Q +++ Q + + + Q E+ Q R + RK + ++ + EE
Sbjct: 1626 QLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLR 1685
Query: 826 GTSTARSVEEVEEE-NDQEME-SFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVER 883
R E E++ QE E F+ EE Q ++ L K E +E Q E+ Q+ R
Sbjct: 1686 RQERDRKFREEEQQLRRQERERKFLQEEQ--QLRRQELERKFRE-EEQLRQETEQEQLRR 1742
Query: 884 EGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEE 943
+ L EE ++ + E+++ +E +++ EEE+ +E+EE++ + ++ EEE
Sbjct: 1743 QERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLR-QEREEQQLRSQESDRKFREEE 1801
Query: 944 DKEEGLEE 951
+ EE
Sbjct: 1802 QLRQEREE 1809
Score = 49.7 bits (117), Expect = 2e-05
Identities = 97/523 (18%), Positives = 210/523 (40%), Gaps = 47/523 (8%)
Query: 589 QECLMHVQNCKKQLLDWKA-------FTEEEAETLVNQFFFQMVGALQGKVEEDLELLDK 641
+E L+ + K++ +W+ +EE + L + + + + + E+ EL +
Sbjct: 1000 EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQE 1059
Query: 642 SFETLADQTEWQS-SHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQ 700
+ L ++ E + L + +++ +L + + E L++E E EKR Q R++ E +
Sbjct: 1060 EEQLLGEERETRRRQELERQYRKEEELQQ--EEEQLLRE-EPEKRRRQERERQCREEEEL 1116
Query: 701 EAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKEL 760
+ ++LL + R++ ++ L + ++ + + LL +E + L+
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQ-------LLREEPEKRRRQELERQ 1169
Query: 761 NSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSE 820
L Q E+ L E K RQ + ++ +++ ++KQ +++ RS+
Sbjct: 1170 YREEEELQQE-------EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSD 1222
Query: 821 ESISSGTSTARSVEEVE-----EENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQG 875
+V + + EN+Q ++ +Q + L + E +E +
Sbjct: 1223 LKWQWEPEKENAVRDNKVYCKGRENEQ-FRQLEDSQLRDRQSQQDLQHLLGEQQERDREQ 1281
Query: 876 LEE--MQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEE 933
Q +R L E K + +S+EE + EE EEK ++ +++ +EE
Sbjct: 1282 ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREE 1341
Query: 934 QESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFIND 993
++ L EE+ + + + E G + LEEE R F+ +
Sbjct: 1342 EQLLQEREEQPLRRQERDRKFREEELRHQEQGRKF-----LEEEQ-RLRRQERERKFLKE 1395
Query: 994 TSSAKFIEQV----TIPSRLILEIKKQLFSEGGNFSPKEINSLCSRLEKEAARIELVESV 1049
+ E+ R E ++QL + + +E R E+E + +E
Sbjct: 1396 EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER---KFLEEE 1452
Query: 1050 IMLNMEKLENEYLDQANDVINKFESKFHNLSVDLIFIEKIQRL 1092
L E+ ++ ++ + + E + H D F+E+ Q+L
Sbjct: 1453 QQLRQER-HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQL 1494
Score = 43.5 bits (101), Expect = 0.002
Identities = 47/205 (22%), Positives = 93/205 (45%), Gaps = 25/205 (12%)
Query: 774 REIFEQNLAGEVIFKFRQPEA----HEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTST 829
R+ EQ L + KFR+ E E+ +R ++ RK + ++ + R E
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE------- 1706
Query: 830 ARSVEEVEEENDQEME-SFITEEVLGQQKKSPLHAKMDE-----SKEGSIQGLEEMQVER 883
+ ++E ++ QE+E F EE L Q+ + + + +E EE Q+ R
Sbjct: 1707 RKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRR 1766
Query: 884 EGSLNPSLNEENVKGQGEKKE----ESE----EEDEKEEEEEEEKLEEEKEEKEAQEEQE 935
+ EE ++ + E+++ ES+ EE++ +E EE++L ++ + + + E+E
Sbjct: 1767 QERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEE 1826
Query: 936 SLSVGEEEDKEEGLEEIYYEDMESF 960
L + E+E + + Y E F
Sbjct: 1827 QLQLEEQEQRLRQERDRQYRAEEQF 1851
Score = 40.0 bits (92), Expect = 0.019
Identities = 42/182 (23%), Positives = 81/182 (44%), Gaps = 18/182 (9%)
Query: 788 KFRQPEAHEKPSQKRVKKLRKKQGSK----EDMTRSEESISSGTSTARSVEEVEEENDQE 843
KFR+ E + ++ K L+++Q + E R EE + T + + E
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751
Query: 844 MESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKK 903
E E Q ++ K E +E Q EE Q+ + S EE ++ + E++
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFRE-EEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQ 1810
Query: 904 EESE---------EEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYY 954
+ EE++ + EE+E++L +E++ + EEQ + E+ +EE +E++
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQ--FATQEKSRREE--QELWQ 1866
Query: 955 ED 956
E+
Sbjct: 1867 EE 1868
Score = 36.2 bits (82), Expect = 0.27
Identities = 26/101 (25%), Positives = 44/101 (43%), Gaps = 6/101 (5%)
Query: 865 MDESKEGSIQGLEEM-----QVEREGSLNPSLNE-ENVKGQGEKKEESEEEDEKEEEEEE 918
+DE K G E + Q E + P + E GQ +++ E+E E E EE+
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 919 EKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDMES 959
+ +E E+++ Q E L +E +E E ++S
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQS 195
Score = 32.7 bits (73), Expect = 3.0
Identities = 36/150 (24%), Positives = 61/150 (40%), Gaps = 15/150 (10%)
Query: 1425 RGQFEEQQKRLEKRKDKNAQKLHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEKL 1484
R Q E+Q R E+ + ++L QE+E + EEE Q+E + ++R EK
Sbjct: 1042 RLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR 1101
Query: 1485 EECTRRNGQVFITNLATFTEKFL---------------LQLDEVVTIDDVQVARMEPPKQ 1529
R L E+ L + +E V ++ Q+ R EP K+
Sbjct: 1102 RRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKR 1161
Query: 1530 KLSMLIRRKLAGLSLKEESEKPLIERGSRK 1559
+ L R+ L++E E+ L E ++
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKR 1191
Score = 32.0 bits (71), Expect = 5.1
Identities = 36/138 (26%), Positives = 62/138 (44%), Gaps = 19/138 (13%)
Query: 1421 VKEIRGQFEEQQKRLEKRKDKNAQKLHLNL----GHPVHFQEMESLHLSEEERQEELDSM 1476
++E R + Q++ + RKDK Q+ L QE E + EEE Q+E + +
Sbjct: 944 LREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL 1003
Query: 1477 IRMNKEKLEECTRRNGQVFITNLATFTEKFLLQLDEVVTIDDVQVARMEPPKQKLSMLIR 1536
+R +EK RR + E+ + DE+ ++ Q+ R E K++L R
Sbjct: 1004 LREEREK-----RRRQE---------WERQYRKKDELQQ-EEEQLLREEREKRRLQERER 1048
Query: 1537 RKLAGLSLKEESEKPLIE 1554
+ L++E E+ L E
Sbjct: 1049 QYREEEELQQEEEQLLGE 1066
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 65.5 bits (158), Expect = 4e-10
Identities = 195/975 (20%), Positives = 384/975 (39%), Gaps = 169/975 (17%)
Query: 270 REKERAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALASFQE 329
R +E K + +E T ++R + I E++ AE KR+ +E+ L +E
Sbjct: 326 RLQELEKIKDLHMAEKTKLITQLRDAKNLI--EQLEQDKGMVIAETKRQMHET-LEMKEE 382
Query: 330 EIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQALLELWDKVA 389
EIAQ+ ++ + T G L++ E E F ++E + T +A +L ++
Sbjct: 383 EIAQLRSRIKQMT--TQGEELREQKEKSERA--AFEELEKALSTAQKTEEARRKLKAEM- 437
Query: 390 GRLLLRKQEIKELDEALHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRPEVYRLINEEAMV 449
++IK +++ S +L V ++ +V++K+S ++ +L
Sbjct: 438 ------DEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKL------- 484
Query: 450 MNYALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFM--A 507
+ K LA+ E L ++L +R R ++ K AL +S SE++ +
Sbjct: 485 -------HEKELAR-----KEQELTKKLQTRER------EFQEQMKVALEKSQSEYLKIS 526
Query: 508 SESIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNK 567
E +ELE+ K + +L+ L + +T++ E SSL +
Sbjct: 527 QEKEQQESLALEELELQKKAILTESENKLRDLQQEAETY-----RTRILELESSLEKSLQ 581
Query: 568 ELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWK----AFTEEEAETLVNQFFFQ 623
E D + + K +E + V+ K +L K A E+ + L Q+ +
Sbjct: 582 ENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTE 641
Query: 624 MVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELE 683
M L+ K E++ E L K E + +H+ + ++ ++ + Q+EL EL
Sbjct: 642 ME-KLREKCEQEKETLLKDKEIIFQ------AHIEEMNEKTLEKLDVKQTELESLSSELS 694
Query: 684 KRMEQHRQKHSLESQVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHT 743
+ + + +H LE + L L+ Q+DK + LE D KN +
Sbjct: 695 EVL---KARHKLEEE---------LSVLKDQTDK--MKQELEAKMDEQKNHHQQQ----- 735
Query: 744 LLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKPSQKRV 803
+ + E+ + + + ++Q E++ K R + H K Q V
Sbjct: 736 -VDSIIKEHEVSIQRTEKALKDQINQL-------------ELLLKER--DKHLKEHQAHV 779
Query: 804 KKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHA 863
+ L + D+ RSE + ++ + + ++ +++ EE L Q +
Sbjct: 780 ENL------EADIKRSEGELQQASAKLDVFQSYQSATHEQTKAY--EEQLAQLQ------ 825
Query: 864 KMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEE 923
Q L +++ ER L ++ + + +KK+ E D + + ++ +
Sbjct: 826 ----------QKLLDLETERI-----LLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQL 870
Query: 924 EKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFVF------------ 971
EK+ E +++ +SL+ E E+G +E E + + N
Sbjct: 871 EKQNSEMEQKVKSLTQVYESKLEDGNKE--QEQTKQILVEKENMILQMREGQKKEIEILT 928
Query: 972 --VPLEEEHCRKSHSTFSAMFINDTSSAKFIE------QVTIPSRLI---LEIKKQLFSE 1020
+ +E+ + + F N + ++ Q T+ +L+ ++KK+L +
Sbjct: 929 QKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENT 988
Query: 1021 GGNFSPKEINSLCSRLEKEAAR-------IELVESVIMLNMEKLENEYLDQANDVINKFE 1073
S KE LE A + +E+ +E L + + NDVI+ +E
Sbjct: 989 ALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE 1048
Query: 1074 SKFHNLSVDLIFIEKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRG 1133
K + + +L I +IQ LQ K + +VA+ + +++ +I +E
Sbjct: 1049 KKLNQQAEELQEIHEIQ-----LQEK-EQEVAELKQKILLFGCEKEEMNKEITWLKEEGV 1102
Query: 1134 EKTTVTTE--ELLSFVQTWKEKLSQRIQYLNCSLDR--VSMTELVFTNTILKDQEEDSDI 1189
++ T E E L L+Q L L++ V + + + NT L++Q
Sbjct: 1103 KQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQ------ 1156
Query: 1190 LTSSEALEEEAKLDV 1204
L + L EE K V
Sbjct: 1157 LVELKMLAEEDKRKV 1171
Score = 62.0 bits (149), Expect = 5e-09
Identities = 246/1239 (19%), Positives = 484/1239 (39%), Gaps = 217/1239 (17%)
Query: 115 REKKLQQSTKYWCLNQSAESLRICAMRGGENRPPARVQSSSEELELRHQSLDAFPGRRLP 174
RE++ Q+ K +E L+I + + + EELEL+ +++ +L
Sbjct: 503 REREFQEQMKVALEKSQSEYLKISQEKEQQE------SLALEELELQKKAILTESENKL- 555
Query: 175 GRGIQPAAKMSSVGKVTQVPNGKAYQQIFQAEVQLVHSLAATRKRAAERSVTLKSGRIPM 234
R +Q A+ +I + E L SL + ++ + +V L++ +
Sbjct: 556 -RDLQQEAETYRT-------------RILELESSLEKSLQENKNQSKDLAVHLEAEKNKH 601
Query: 235 MKKVETPEGEVMSPRQQKWMHSLPND----WIMENPVLHR----EKERAKREKARESENT 286
K++ VM + + + SL + W + VL + E E+ + + +E E
Sbjct: 602 NKEIT-----VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETL 656
Query: 287 IAAREVRGLMDTIVPEKISTSTFQRQ--AEHKRKSYESALASFQEEIAQVGKEMEPLIVD 344
+ +E+ + + E+++ T ++ + + +S S L+ + ++ +E+ L
Sbjct: 657 LKDKEI--IFQAHI-EEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQ 713
Query: 345 TGGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQALLE-LWDKVAGRLLLRKQEIKELD 403
T + + + DE+ N +V++ + +IQ + L D++ LL K+ K L
Sbjct: 714 TDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLK 773
Query: 404 EALHSLEFSRTDKLKS------------VLKKYAEVIEKTSYLMRPEVYRLINEEAMVMN 451
E +E D +S V + Y + + ++ +L ++ + +
Sbjct: 774 EHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQL-QQKLLDLE 832
Query: 452 YALLGNRKALAQLFVNLMESTLQQELDSRHRWQGLVDTWKALKK-----EALLQSFSEFM 506
+ K +A+ V + + ELD+ H+ Q + D + L+K E ++S ++
Sbjct: 833 TERILLTKQVAE--VEAQKKDVCTELDA-HKIQ-VQDLMQQLEKQNSEMEQKVKSLTQVY 888
Query: 507 ASESIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLN 566
S+ + +++++ +N++ Q R I ++L S + S++ LN
Sbjct: 889 ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEI-EILTQKLSAKE-----DSIHILN 942
Query: 567 KELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLV-------NQ 619
+E +T + + EK Q+ + KK+LLD +A ++E E Q
Sbjct: 943 EEYETKFKNQEKKM----EKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998
Query: 620 FFFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEA---HQSELL 676
F +M+ Q + + + +Q E + + +V+ +WE Q+E L
Sbjct: 999 FNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058
Query: 677 -----VQELELEKRMEQHRQKHSL-----------------ESQVQEAHLDRLLDQLRQQ 714
+Q E E+ + + +QK L E Q+ L+ L +QL+Q+
Sbjct: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK 1118
Query: 715 S--------DKETLAFHLEKVK-DYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSS 765
S D+ L HLEK++ D K++K +T L ++++E + ++ S
Sbjct: 1119 SAHVNSLAQDETKLKAHLEKLEVDLNKSLKE-----NTFLQEQLVELKMLAEEDKRKVSE 1173
Query: 766 ALSQYFFVREIFEQ-NLAGEVIFKFRQPEAHE--KPSQKRVKKL----RKKQGSKEDMTR 818
S+ E F+ + E K + ++ E K S++ +L +K + E T
Sbjct: 1174 LTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTN 1233
Query: 819 SEESISSGTSTAR-----------------------SVEEVEEENDQEMESFITEEVLGQ 855
+ISS + A +V E+E + Q E T + Q
Sbjct: 1234 ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQ 1293
Query: 856 QKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGE------KKEESE-- 907
Q L K ++ K +E + E+E N++ + E KKE SE
Sbjct: 1294 QATHQLEEKENQIKSMKAD-IESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENI 1352
Query: 908 ------EEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDMESFT 961
+E+ KE++ E L ++ + Q Q S+S+ E+E L + Y
Sbjct: 1353 NAVTLMKEELKEKKVEISSLSKQLTDLNVQL-QNSISLSEKEAAISSLRKQY-------- 1403
Query: 962 ISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKFI---EQVTIPSRLILEIKKQLF 1018
+EE C F DT S + I EQV S E KK+
Sbjct: 1404 -------------DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQ 1450
Query: 1019 SEGGNFSPKEINSLCSRLEKEAARIELVESVIMLNMEKLENEYLDQANDVINKFESKFHN 1078
S F+ + +++ E E E +N+ K E LDQ N +F+
Sbjct: 1451 SR---FTQHQNTVKELQIQLELKSKEAYEKDEQINLLK---EELDQQN---KRFDCLKGE 1501
Query: 1079 LSVDLIFIEKIQRLLTNLQVKIKCQVAKSNSQTNGLN---FSLQQLQNKIKTCQESRGEK 1135
+ D +EK + +NL+ ++K Q A+ + + ++ L +K + + +
Sbjct: 1502 MEDDKSKMEKKE---SNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIE 1558
Query: 1136 TTVTTEELLSFVQTWKEK-------------LSQRIQYLNCSLDRVSMTELVFTNTILKD 1182
++L F + +EK L ++ + L+ EL N +K
Sbjct: 1559 HKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELE-TKKKELEHVNLSVKS 1617
Query: 1183 QEEDSDILTSSEALEEEAKLDVVTPESFTQLSRVGKPLI 1221
+EE+ L E AKL + ++ +++ + K L+
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLL 1656
Score = 56.6 bits (135), Expect = 2e-07
Identities = 199/1001 (19%), Positives = 382/1001 (38%), Gaps = 139/1001 (13%)
Query: 286 TIAAREVRGLMDTIVPEKISTSTFQRQAEHKRKSYESALASFQEEIAQVGKEMEPLIVDT 345
T E+ + + E+ + + +QA H+ + E+ + S + +I + E E L +
Sbjct: 1268 TCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEG 1327
Query: 346 GGLFLKKLTESDEEMNRLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEA 405
G ++ S++E LK E N+ T L K+E+KE
Sbjct: 1328 GN---QQQAASEKESCITQLKKELSENINAVT----------------LMKEELKEKKVE 1368
Query: 406 LHSLEFSRTDKLKSVLKKYAEVIEKTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQLF 465
+ SL TD L L+ + EK + + + + +EE LL + L+
Sbjct: 1369 ISSLSKQLTD-LNVQLQNSISLSEKEAAIS--SLRKQYDEEKC----ELLDQVQDLS-FK 1420
Query: 466 VNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQ---SFSEFMASESIHTPPAVTKELE 522
V+ + L+ W WK + Q + E + + A K+ +
Sbjct: 1421 VDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQ 1480
Query: 523 VMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRL 582
+ L + + QQ K + + SK + E ++L EL + M
Sbjct: 1481 INLLKEELDQQN--KRFDCLKGEMEDDKSKMEKKE-----SNLETELKSQTARIMELEDH 1533
Query: 583 LYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQF-FFQMVGALQG----KVEEDLE 637
+ +KT + +++ + L ++ + E + LV + FQ +G + + EE +
Sbjct: 1534 ITQKT-----IEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588
Query: 638 LLDKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLES 697
L+ ++ + E + L E V L + E L LE R+E ES
Sbjct: 1589 TLENQVYSMKAELETKKKEL-----EHVNLSVKSKEEELKA---LEDRLES-------ES 1633
Query: 698 QVQEAHLDRLLDQLRQQSDKETLAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIML 757
+ A L R +Q K+ L+ EK + Y K +S +T L + E I+
Sbjct: 1634 AAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVH-ILE 1692
Query: 758 KELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAH-----EKPSQKRVKKLRKKQGS 812
++L S S+ S+ V A V Q EA +K ++++ L++
Sbjct: 1693 EKLKSVESSQSETLIV-----PRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTE 1747
Query: 813 KEDMTR-----SEESISSGTSTARSVEE---------VEEENDQEMESFITEEVLGQQKK 858
KE + + EE++SS +E ++ DQ M + EE+ + KK
Sbjct: 1748 KEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKK 1807
Query: 859 SPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEE 918
L + VE+EG N ++N++ + +++ +E E + E
Sbjct: 1808 YSL--------------IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILE 1853
Query: 919 EKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFVFVPLEEEH 978
+K++E Q+E + + E K E L+ + D N + E
Sbjct: 1854 QKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMD-------GRNKPTELLEENTEE 1906
Query: 979 CRKSHSTFSAMFINDTSSAKFIE-QVTIPSRLILEIKKQL--FSEGGNFSPKEINSLCSR 1035
KSH + N + +E ++ R ++ K++ + KE
Sbjct: 1907 KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEI 1966
Query: 1036 LEKEAARIELVESVIMLNMEKLENEYLDQANDVINKFESKFHNLSVDLIFIEKIQRLLTN 1095
L+KE + E I E LE ++ ++ +F ++ +L E + N
Sbjct: 1967 LKKEYDQER--EEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL---EMTIKETIN 2021
Query: 1096 LQVKIKCQVAKSN-SQTNGL-------NFSLQQLQNKIKTCQESRGEKTTVTTEELLSFV 1147
+++ ++ +S+ +TN L + L++ + + ++R E+ T +L + +
Sbjct: 2022 KAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQL 2081
Query: 1148 QTWKEKLSQRI-QYLNCSLDRVSMTEL---------VFTNTILKDQEEDSDILTSSEALE 1197
+ ++K Q++ Q N D V++ EL + +++ LK+QE I + L+
Sbjct: 2082 EELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLK 2141
Query: 1198 EEAK----LDVVTPESFTQLSRVGKPLIEDPA-VDVIRKLL 1233
+ K V TP L L +P + +RK+L
Sbjct: 2142 KYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVL 2182
Score = 55.8 bits (133), Expect = 3e-07
Identities = 224/1115 (20%), Positives = 447/1115 (40%), Gaps = 187/1115 (16%)
Query: 662 QEVVQLWEAHQSELLVQELE-LEKRMEQHRQKHS---LESQVQEAHLDRLLDQLRQQSDK 717
+++V ++ E L+Q L +E+ + +R K+S Q+ + +L L Q DK
Sbjct: 125 EDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDK 184
Query: 718 ET--LAFHLEKVKDYLKNMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQ----YF 771
+A E+++ + K E F L +E +Y +++ +++ L
Sbjct: 185 SLRRIAELREELQMDQQAKKHLQEEFDASL-EEKDQYISVLQTQVSLLKQRLRNGPMNVD 243
Query: 772 FVREIFEQNLAGEVIFKFRQPEAHEKP------SQKRVKKLRKKQGSKEDMT-RSEESIS 824
++ + + EV K PE+ +P S K ++ L+++ +E++ R +E+I
Sbjct: 244 VLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQ 303
Query: 825 SG-------TSTARSVEEVEEENDQEMESF-----------ITE--------EVLGQQK- 857
S TS +++E +E QE+E IT+ E L Q K
Sbjct: 304 SHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKG 363
Query: 858 ------KSPLHAKMDESKEGSIQGL-----------EEMQVEREGSLNPSLNE-ENVKGQ 899
K +H + E KE I L EE++ ++E S + E E
Sbjct: 364 MVIAETKRQMHETL-EMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALST 422
Query: 900 GEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEE---------EDKEEGLE 950
+K EE+ + + E +E+ + +E+ EE+ +QE V +E E++ L+
Sbjct: 423 AQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQ 482
Query: 951 EIYYEDM----ESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKFIEQVTIP 1006
+++ +++ + T F + KS S + + S K ++
Sbjct: 483 KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKI-----SQEKEQQESLAL 537
Query: 1007 SRLILEIKKQLFSEGGNFSPKEINSLCSRLEKEAARIELVESVIMLNMEKLENEYLDQAN 1066
L L+ KK + +E N ++ L E RI +ES + ++++ +N+ D A
Sbjct: 538 EELELQ-KKAILTESEN----KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLA- 591
Query: 1067 DVINKFESKFHNLSVDLIFIEKIQRLLTNLQVK------IKCQVAKSNSQTNGLNFSLQQ 1120
V + E HN + + +EK + L +L+ + K QV K QT +++
Sbjct: 592 -VHLEAEKNKHNKEI-TVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQT-----EMEK 644
Query: 1121 LQNKIKTCQESRGEKTTVTTEELLSF---VQTWKEKLSQRIQYLNCSLDRVS--MTELVF 1175
L+ K C++ EK T+ ++ + F ++ EK +++ L+ +S ++E++
Sbjct: 645 LREK---CEQ---EKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLK 698
Query: 1176 TN-------TILKDQ----EEDSDILTSSEALEEEAKLDVVTPESFTQLSRVGKPLIEDP 1224
++LKDQ +++ + + + ++D + E + R K L +
Sbjct: 699 ARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ- 757
Query: 1225 AVDVIRKLLQLPNTKWPTHHCDKDPSQTGFKRHRCQPENSGKKAVPSASATSAGSLQTTH 1284
++ + LL+ + H + + KR + + + K S SA QT
Sbjct: 758 -INQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT-- 814
Query: 1285 PPLSHSFTPHPKPNKMERKYRVLGDKPPPAAEDFKGIILTLLWESSENLLTVAEEFYRKE 1344
+ R+L K E K + T L + + ++ ++
Sbjct: 815 KAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQN 874
Query: 1345 KRPVTRPDCMCDTFDQCAENISKKILEYQSQANKYHNSCLIELRIQIRRFEELLPQVCWL 1404
+ + ++ E+ +K+ E Q + ++++R ++ E+L Q
Sbjct: 875 SEMEQKVKSLTQVYESKLEDGNKE-QEQTKQILVEKENMILQMREGQKKEIEILTQKL-- 931
Query: 1405 VMENFKEHHWKKFFTSVKEIRGQFEEQQKRLEKRKDKNAQKLHLNLGHPVHFQEME---- 1460
+ KE +E +F+ Q+K++EK K K A+++ L + QE +
Sbjct: 932 ---SAKE---DSIHILNEEYETKFKNQEKKMEKVKQK-AKEMQETLKKKLLDQEAKLKKE 984
Query: 1461 ----SLHLSEEERQEEL--------------DSMIRM---NKEKLEECTRRNGQVFITNL 1499
+L LS++E+Q D++ R+ KE++E T + + +
Sbjct: 985 LENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVI 1044
Query: 1500 ATFTEKFLLQLDEVVTIDDVQVARMEPPKQKLSMLIRRKLAGLSLKEESEKP---LIERG 1556
+ + +K Q +E+ I ++Q+ E Q+++ L ++ L KEE K L E G
Sbjct: 1045 SIWEKKLNQQAEELQEIHEIQLQEKE---QEVAELKQKILLFGCEKEEMNKEITWLKEEG 1101
Query: 1557 SRKWPGIKPTEVTIQNKILLQPTSSISTTKTTL-GHLAAVEA-------------RDAVY 1602
++ + + ++ K +S++ +T L HL +E V
Sbjct: 1102 VKQDTTLNELQEQLKQK--SAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE 1159
Query: 1603 LKYLASFEEELKRIQDDCTSQIKEAQRWKDSWKQS 1637
LK LA EE KR + TS++K S K S
Sbjct: 1160 LKMLA---EEDKRKVSELTSKLKTTDEEFQSLKSS 1191
Score = 55.5 bits (132), Expect = 4e-07
Identities = 207/1049 (19%), Positives = 387/1049 (36%), Gaps = 161/1049 (15%)
Query: 237 KVETPEGEVMSPRQQKWMHSLPNDWIMENPVL--HREKERAKREKARESENTIAAREVRG 294
K +T E+ +QK H N + L H EK K+ + ENT ++
Sbjct: 1103 KQDTTLNELQEQLKQKSAHV--NSLAQDETKLKAHLEKLEVDLNKSLK-ENTFLQEQLVE 1159
Query: 295 LMDTIVPEKISTS-------TFQRQAEHKRKSYESALASFQEEIAQVGKEMEPLIVDTGG 347
L +K S T + + + S+E + S +++ + K E L +
Sbjct: 1160 LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDI 1219
Query: 348 LFLKKLTESDEEMNRLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALH 407
K + + N L + TN I KV LL++ + EL+ L
Sbjct: 1220 CCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279
Query: 408 SLEFSRTDKLKSVLKKYAEVIEKTSYL--MRPEVYRLINEEAMVMNYALLGNRKALAQLF 465
L + S + ++ EK + + M+ ++ L+ E+ + GN++ A
Sbjct: 1280 QLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEG--GNQQQAA--- 1334
Query: 466 VNLMESTLQQELDSRHRWQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKEL-EVM 524
+ ES + Q LKKE SE+I+ + +EL E
Sbjct: 1335 -SEKESCITQ-----------------LKKEL----------SENINAVTLMKEELKEKK 1366
Query: 525 LKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLL- 583
++ ++ +Q + DL + L+E ++++SL K+ D + + ++ L
Sbjct: 1367 VEISSLSKQ--------LTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLS 1418
Query: 584 -----YEKTWQECLMHVQNCKKQLLDWKA-----FTEEEAETLVNQFFFQMVGALQGKVE 633
K L V + + +WK FT+ + Q ++ + +
Sbjct: 1419 FKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKD 1478
Query: 634 EDLELL-------DKSFETLADQTEWQSSHLFKYFQEVVQLWEAHQSELLVQELELEKRM 686
E + LL +K F+ L + E S + K + L EL+ +
Sbjct: 1479 EQINLLKEELDQQNKRFDCLKGEMEDDKSKMEK------------KESNLETELKSQTAR 1526
Query: 687 EQHRQKHSLESQVQEAHLDRLLDQLRQQSDKE--TLAFHLEKVKDYLKNMKSRY-ECFHT 743
+ H + ++ L+ +L QQ D E L L+ ++ + +R E
Sbjct: 1527 IMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEK 1586
Query: 744 LLTKEVMEYPA-----IMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHEKP 798
+LT E Y KEL + ++ + E L E K + + +
Sbjct: 1587 ILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ 1646
Query: 799 SQKRVKK--LRKKQGSKEDMTRSEESISSGTSTARSVEEVE----EENDQEMESFITEEV 852
+KK L + + +E + ES S +T E E EE + +ES +E +
Sbjct: 1647 KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL 1706
Query: 853 LGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSL---NPSLNEENVKGQGEKKEESE-- 907
+ + + A E +E QG + E + S+ N + E+ ++ G++KEE+
Sbjct: 1707 IVPRSAKNV-AAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSS 1765
Query: 908 ---------------EEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEI 952
E E ++ E++ + +EE E + ++ SL V + +KE G I
Sbjct: 1766 HFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNI 1825
Query: 953 YYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRLILE 1012
+ L + + + + + +E + S+ E
Sbjct: 1826 QAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHR-VEMEELTSK--YE 1882
Query: 1013 IKKQLFSEGGNFSPKEINSLCSRLEKEAARIELVESVIMLNMEKLENEYLDQANDVINKF 1072
+ L G P E L +E ++ LV+ ++ NME Q ND+ K
Sbjct: 1883 KLQALQQMDGRNKPTE---LLEENTEEKSKSHLVQPKLLSNMEA-------QHNDLEFKL 1932
Query: 1073 ---ESKFHNLSVDLIFIEKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQ 1129
E + L +++ ++K R+L + + + ++ K Q+ + KIK Q
Sbjct: 1933 AGAEREKQKLGKEIVRLQKDLRMLRK-EHQQELEILKKEYD--------QEREEKIKQEQ 1983
Query: 1130 ESRGEKTTVTTEELLSFVQTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDI 1189
E K T ++L+ + + +L+Q+ Q L E+ TI K QE ++++
Sbjct: 1984 EDLELKHNSTLKQLM---REFNTQLAQKEQEL----------EMTIKETINKAQEVEAEL 2030
Query: 1190 LTSSEALEEEAKLDVVTPESFTQLSRVGK 1218
L S + EE +L E L R K
Sbjct: 2031 LESHQ--EETNQLLKKIAEKDDDLKRTAK 2057
Score = 53.9 bits (128), Expect = 1e-06
Identities = 154/763 (20%), Positives = 312/763 (40%), Gaps = 146/763 (19%)
Query: 263 MENPVLHREKERA--KREKARESENTIAAREVRGL---MDTIVPEKIST----STFQRQA 313
++N + EKE A K + E +V+ L +DT+ EKIS + +
Sbjct: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442
Query: 314 EHKRKSYESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMNRLFLKVENDTNL 373
+K +S Q + ++ ++E L K+ E DE++N L +++
Sbjct: 1443 SEWKKKAQSRFTQHQNTVKELQIQLE--------LKSKEAYEKDEQINLLKEELDQQNKR 1494
Query: 374 EDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDK------LKSVLKKYAEV 427
D + + K+ + + E+K + LE T K L VLK Y +
Sbjct: 1495 FDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQ 1554
Query: 428 --IEKTSYLMRPEVYRLINEEAMVMNYALLGNRKALAQLFVNLMES---TLQQELDSRHR 482
IE + + + ++ + EE NR A+ + +E+ +++ EL+++ +
Sbjct: 1555 KDIEHKELVQKLQHFQELGEEK--------DNRVKEAEEKILTLENQVYSMKAELETKKK 1606
Query: 483 WQGLVDTWKALKKEALLQSFSEFMASESIHTPPAVTKELEVMLKTQNVLQQRRLKHLCTI 542
V+ KE L++ + + SES K E+ K + + + K L +
Sbjct: 1607 ELEHVNL-SVKSKEEELKALEDRLESES------AAKLAELKRKAEQKIAAIK-KQLLSQ 1658
Query: 543 CDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDCMMWIRLLYEKTWQECLMHVQNCKKQL 602
+ Y K TE H L+ LN +L + + +L EK L V++ + +
Sbjct: 1659 MEEKEEQYKKG--TESH--LSELNTKLQERERE----VHILEEK-----LKSVESSQSET 1705
Query: 603 L-------DWKAFTEEE---AETLVNQFFFQMVGALQGKVEEDLELLDKSFETLADQTEW 652
L + A+TE+E ++ V + + + + LQ + E +LL + + ++ E
Sbjct: 1706 LIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ---EKEET 1762
Query: 653 QSSHL---FKYFQEVVQLWEA----HQSELLVQEL--ELEKR-------MEQHRQKHSLE 696
SSH +Y + +++L A H+ + ++ L ELE++ + QH +K +
Sbjct: 1763 VSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGK 1822
Query: 697 SQVQ-EAHLDRLLDQLRQQSDKETLAFHL--EKVKDY--------------LKNMKSRYE 739
+ +Q + +L+ + D +++ ++ L + +K+K+ ++ + S+YE
Sbjct: 1823 NNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYE 1882
Query: 740 CFHTLLTKEVMEYPAIMLKELNSYSSA--LSQYFFVREIFEQNLAGEVIFKFRQPEAHEK 797
L + P +L+E S L Q + + Q+ ++ FK E ++
Sbjct: 1883 KLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQH--NDLEFKLAGAEREKQ 1940
Query: 798 PSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQK 857
K + +L+K M R E + +E +++E DQE E I +E
Sbjct: 1941 KLGKEIVRLQKDLR----MLRKEHQ--------QELEILKKEYDQEREEKIKQEQ----- 1983
Query: 858 KSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEE 917
E+++++ +L + E N Q +KE+ E KE +
Sbjct: 1984 -------------------EDLELKHNSTLKQLMREFNT--QLAQKEQELEMTIKETINK 2022
Query: 918 EEKLEEEKEEKEAQEEQESL-SVGEEEDKEEGLEEIYYEDMES 959
+++E E E +E + L + E++D + + Y E +++
Sbjct: 2023 AQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDA 2065
Score = 31.2 bits (69), Expect = 8.7
Identities = 52/254 (20%), Positives = 106/254 (41%), Gaps = 53/254 (20%)
Query: 1387 LRIQIRRFEELLPQVCWLVMENFKEHHWKKFFTSVKE-IRGQFEEQQKRLEKRKDKNAQK 1445
L+ +++R E LL + C +++ KE TS KE ++ Q +E+ + LEK KD
Sbjct: 284 LQQRVKRQENLLKR-CKETIQSHKEQC--TLLTSEKEALQEQLDERLQELEKIKD----- 335
Query: 1446 LHLNLGHPVHFQEMESLHLSEEERQEELDSMIRMNKEKLEECTRRNGQVFITNLATFTEK 1505
LH++E+ + L + +R K +E+ + G V
Sbjct: 336 ----------------LHMAEKTK---LITQLRDAKNLIEQLEQDKGMVIAETKR----- 371
Query: 1506 FLLQLDEVVTIDDVQVARMEPPKQKLSMLIRRKLAGLSLKEESEKPLIERGSRKWPGIKP 1565
Q+ E + + + ++A++ + ++ + + KE+SE+ E + +
Sbjct: 372 ---QMHETLEMKEEEIAQL---RSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQK 425
Query: 1566 TEVTIQNKILLQPTSSISTTKTTLGHLAAVEARDAVYLKYLASFEEELKRIQDDCTSQIK 1625
TE + K+ + I T + T + E R S ++EL R++ + +K
Sbjct: 426 TEEA-RRKLKAEMDEQIKTIEKT-----SEEER--------ISLQQELSRVKQEVVDVMK 471
Query: 1626 EAQRWKDSWKQSLH 1639
++ + + Q LH
Sbjct: 472 KSSEEQIAKLQKLH 485
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 64.7 bits (156), Expect = 7e-10
Identities = 153/732 (20%), Positives = 302/732 (41%), Gaps = 118/732 (16%)
Query: 573 HVDCMMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVG------ 626
H M +++ + K K Q+ + + E E L NQ +
Sbjct: 588 HQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEME 647
Query: 627 ALQGKVEEDLELLDKSFETLADQTEW-QSSHLFKYFQEVVQLWEAHQSELLVQELEL--E 683
AL+ K+ + ++ + S E + + + + HL + + +L EA E+ V+ELE+
Sbjct: 648 ALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA---EIKVKELEVLQA 704
Query: 684 KRMEQHRQKHSLESQVQEAHLDRL-LDQLRQ-----QSDKETLAFHLEKVKDYLKNMKSR 737
K EQ + + SQ++ L LD LR+ +S+ + L LE + +K+++
Sbjct: 705 KCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE 764
Query: 738 YECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHE- 796
+ + E LK L + LS+ V+E E+ L I K + EA E
Sbjct: 765 KNAESSKASSITRELQGRELK-LTNLQENLSEVSQVKETLEKELQ---ILKEKFAEASEE 820
Query: 797 -----KPSQKRVKKLRKKQGS----KEDMTRSEESISSGTSTARSVEEVEEE---NDQEM 844
+ Q+ V KL +K+ D+ + E+++ + R +E EE+ +++
Sbjct: 821 AVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL 880
Query: 845 ESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVE-REGSLNPSLNEENVKGQGEKK 903
E+ I E + S KM++ + +EE+Q++ + + N S +++++ K
Sbjct: 881 ENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKA 940
Query: 904 EESEEEDEKEEEEEEEKLEEEKEEKEAQEE-----------------QESLSVGEE---- 942
E+S++E K+ EEE+++LE + + E + E E+ + EE
Sbjct: 941 EQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQN 1000
Query: 943 --------EDKEEG--------LEEIYYEDMESFTISSGNTYFVFVPLEEEHCRKSHSTF 986
EDK +G L+E+ ++ + T + + E+ ++ T
Sbjct: 1001 LQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETL 1060
Query: 987 SAMFINDTSSAKF------IEQVTIPSRLILEIKKQLFSEGGNFSPKEINSLCSRLEKEA 1040
+++ ++AK +++ + + L K+L + N +E L++ A
Sbjct: 1061 ASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTV-ENQKMEEFRKEIETLKQAA 1119
Query: 1041 ARIELVESVIMLNMEKLENEYLDQANDVI---NKFESKFHNLSVDLIFIEKIQRLLTNLQ 1097
A+ S + KL E L ++ D + K E + L+ L+ ++K +
Sbjct: 1120 AQKSQQLSALQEENVKLAEE-LGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDA 1178
Query: 1098 VKIKCQVAKSNSQTNGL----NFSLQQLQNKIKTCQESRGEKTTVTTEELLSFVQTW--- 1150
+ K + KS S T+ L + L++L+N++ RGE + + L S VQT
Sbjct: 1179 DEEKASLQKSISITSALLTEKDAELEKLRNEVTVL---RGE--NASAKSLHSVVQTLESD 1233
Query: 1151 KEKLSQRIQYLNCSL---------------------DRVSMTELVFTNTILKD-QEEDSD 1188
K KL +++ L L +R +++ F N+++ D Q ++ D
Sbjct: 1234 KVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQD 1293
Query: 1189 ILTSSEALEEEA 1200
+ E + E A
Sbjct: 1294 LKMKVEMMSEAA 1305
Score = 47.0 bits (110), Expect = 2e-04
Identities = 168/898 (18%), Positives = 335/898 (37%), Gaps = 138/898 (15%)
Query: 793 EAHEKPSQKRVKKLRKKQGSKEDMTR--SEESISSGTSTARSVEEVEEENDQEMESFITE 850
EA ++ + + +L +++ ED+ EESI+ G +V E + E+E +
Sbjct: 418 EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSE--KSRIMELEKDLAL 475
Query: 851 EVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEED 910
V Q+ + L +++ +K + ++ SL L Q E E
Sbjct: 476 RV---QEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFG 532
Query: 911 EKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEEIYYEDMESFTISSGNTYFV 970
+EE ++E ++ +E ESL E +E + I + T
Sbjct: 533 AREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETA-------- 584
Query: 971 FVPLEEEHCRKSHSTFSAMFINDTSSAKFIEQVTIPSRLILE-------IKKQLFSEGGN 1023
+ ++ + +FS T +A+F E T ++ L+ ++ Q SE
Sbjct: 585 -IASHQQAMEELKVSFSKGL--GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAA 641
Query: 1024 FSPKEINSLCSRLEKEAARIELVESVIMLNMEKLENEYLDQANDVINKFESKFHNLSVDL 1083
+ KE+ +L ++L K E I ++K E+++L + D +NK + + +
Sbjct: 642 HA-KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQ----EAEIKV 696
Query: 1084 IFIEKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGEKTTV----- 1138
+E +Q N Q K+ + SQ L L K E + E +
Sbjct: 697 KELEVLQ-AKCNEQTKV---IDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE 752
Query: 1139 TTEELLSFVQTWKEKLSQRIQYLNCSLDRVSMTELVFTNTILKDQEEDSDILTSSEALEE 1198
E+ + ++ K S + + L EL TN QE S++ E LE+
Sbjct: 753 AAEKQIKHLEIEKNAESSKASSITRELQG---RELKLTNL----QENLSEVSQVKETLEK 805
Query: 1199 EAKLDVVTPESFTQLSRVGKPLIEDPAVDVIRKLLQLPNTKWPTHHCDKDPSQTGFKRHR 1258
E + + E F + S + AV V R + + N K H+
Sbjct: 806 ELQ---ILKEKFAEAS--------EEAVSVQRSMQETVN-----------------KLHQ 837
Query: 1259 CQPENSGKKAVPSASATSAGSLQTTHPPLSHSFTPHPKPNKMERKYRVLGDKPPPAAEDF 1318
K+ + ++ L+ + F K ER+ +++ K E+
Sbjct: 838 -------KEEQFNMLSSDLEKLRENLADMEAKFR-----EKDEREEQLI--KAKEKLEND 883
Query: 1319 KGIILTLLWESSENLLTVAEEFYRKEK------RPVTRPDCMCDTFDQCAENISKKILEY 1372
I+ + ++S L + +E KE+ +T+ + + E+++ K +
Sbjct: 884 IAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQS 943
Query: 1373 QSQANKYHNSCLIELRIQIRRFEELLPQVCWLVMENFKEHHWKKFFTSVKEIRGQFEEQQ 1432
Q +A K H EL ++ E+ + N + ++ + E + + EE
Sbjct: 944 QQEAAKKHEEEKKELERKLSDLEKKME-----TSHNQCQELKARYERATSETKTKHEEIL 998
Query: 1433 KRLEKR------KDKNAQKLHLNLGHPVHFQEMESLHLSEEE------RQEELDSMIRMN 1480
+ L+K K K A++ + L QE+E L ++ ++ + M +M
Sbjct: 999 QNLQKTLLDTEDKLKGAREENSGL-----LQELEELRKQADKAKAAQTAEDAMQIMEQMT 1053
Query: 1481 KEKLE-----ECTRRNGQVFITNLATFTEKFLLQLD------EVVTIDDVQVARMEPPKQ 1529
KEK E E T++ L T E L ++ E++T+++ ++ +
Sbjct: 1054 KEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIE 1113
Query: 1530 KLSMLIRRKLAGLSLKEESEKPLIERGSR------KWPGIKPTEVTIQNKILLQPTSSIS 1583
L +K LS +E L E R ++ + N++L
Sbjct: 1114 TLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESK 1173
Query: 1584 TTKTTLGHLAAVEARDAVYLKYLASFEEELKRIQDDCTSQIKEAQRWKDSWKQSLHTI 1641
K A+++ ++ L + EL++++++ T R +++ +SLH++
Sbjct: 1174 FIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVT-----VLRGENASAKSLHSV 1226
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 64.3 bits (155), Expect = 9e-10
Identities = 111/549 (20%), Positives = 233/549 (42%), Gaps = 68/549 (12%)
Query: 674 ELLVQELELEKRMEQHRQKHSLESQVQ-EAHLDRLLDQLRQQSDKETLAFHLEKVKDYLK 732
E V+E++ K+ Q + LE + Q + L+R L L+ S++ A L+++K +
Sbjct: 1376 ERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRA--LQQLKKKCQ 1433
Query: 733 NMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQP 792
+ + + TK +E + EL Q F E+ + + + R+
Sbjct: 1434 RLTAELQD-----TKLHLEGQQVRNHELEK-----KQRRFDSELSQAHEEAQ-----REK 1478
Query: 793 EAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVE-EVEEENDQEMESFITEE 851
EK +++ L + K+ + + I+ T S+E E+++ + QE + E
Sbjct: 1479 LQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD---EA 1535
Query: 852 VLGQQKKS--PLHAKMDESKE------GSIQGLEE--MQVEREGSLNPSLNEENVKGQGE 901
L + KK L AK+ + +E G+IQ LE+ +++E E + + ++ + E
Sbjct: 1536 SLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDE 1595
Query: 902 KKEESEEEDEKEEEEEEEKLEEEKEEK-----EAQEEQESLSVGEEEDKEEGLEEIYYED 956
+ EE+ + +K+ ++ E +LEEE E+K E +E + L+ ++ E E
Sbjct: 1596 EVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFES---EK 1652
Query: 957 MESFTISSGNTYFVFVPLEEEHCRKSHSTFS--AMFINDTSSAKFIEQVTIPSRLILEIK 1014
+ L +H + S + A N ++F + +R +E++
Sbjct: 1653 RLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVE 1712
Query: 1015 KQLFSEGGNFSPKEINSLCSRLEKEAARIELVESVIMLNMEKLENEYLDQANDVINKFES 1074
E + +I + LE++ +R++ ++ I +E E + N+++ K ++
Sbjct: 1713 ----IEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLE----EDQEDMNELMKKHKA 1764
Query: 1075 KFHNLSVDLIFIEKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGE 1134
S DL I +Q Q+ ++N + L LQ LQ++++ ++S +
Sbjct: 1765 AVAQASRDLAQINDLQ-----------AQLEEANKEKQELQEKLQALQSQVEFLEQSMVD 1813
Query: 1135 KTTVTTEELLSFVQTWKEKLSQRIQYLNCSLDRV-SMTELVFTNTILKDQEEDSDILTSS 1193
K+ V+ +E +L R+++ + R+ S+ + N +E D I +
Sbjct: 1814 KSLVSRQEAKI------RELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAEN 1867
Query: 1194 EALEEEAKL 1202
E+ +L
Sbjct: 1868 REKEQNKRL 1876
Score = 44.3 bits (103), Expect = 0.001
Identities = 85/404 (21%), Positives = 167/404 (41%), Gaps = 74/404 (18%)
Query: 599 KKQLLDWKAFTEEEAETLVNQF-FFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHL 657
KKQL D +A +++ E L Q QM+ + ++E ++E + ++ S +
Sbjct: 1541 KKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQT----------HSKEM 1590
Query: 658 FKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQS-- 715
+EV + ++ Q +L E++LE+ E +QK E + E L L DQ+ ++
Sbjct: 1591 ESRDEEVEEARQSCQKKLKQMEVQLEEEYED-KQKVLREKRELEGKLATLSDQVNRRDFE 1649
Query: 716 DKETLAFHLEKVK----------DYLKNM---------------KSRYECFHTLLTKEVM 750
++ L L++ K D+LKN +S + C + ++ M
Sbjct: 1650 SEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAM 1709
Query: 751 EYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHE-----KPSQKRVKK 805
E + +++L + + +I + A E Q E +E + Q+ + +
Sbjct: 1710 E---VEIEDL---------HLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNE 1757
Query: 806 LRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMES---------FITEEVLGQQ 856
L KK K + ++ ++ +EE +E + E F+ + ++ +
Sbjct: 1758 LMKKH--KAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKS 1815
Query: 857 KKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEE 916
S AK+ E + + E QV+R SL L E K EE ++ E E
Sbjct: 1816 LVSRQEAKIRELE--TRLEFERTQVKRLESLASRLKENMEK----LTEERDQRIAAENRE 1869
Query: 917 EEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLE-EIYYEDMES 959
+E+ +++ ++ +EE L+ E E + E E+ E +E+
Sbjct: 1870 KEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEA 1913
Score = 40.8 bits (94), Expect = 0.011
Identities = 134/755 (17%), Positives = 286/755 (37%), Gaps = 148/755 (19%)
Query: 262 IMENPVLHREKE----RAKREKARESENTIAAREVRGLMDTIVPEKISTSTFQRQAEH-- 315
+ E + ++++E R+K EKA + N + R +++ + E S T +R
Sbjct: 1251 LSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDR--LESRISELTSELTDERNTGESA 1308
Query: 316 ---------KRKSYESALASFQEEIAQVGKEMEPLIVDTGGLFLKKLTESDEEMN----- 361
+R E + Q + + K+ME + ++ L + E + E++
Sbjct: 1309 SQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAG 1368
Query: 362 -RLFLKVENDTNLEDYTIQALLELWDKVAGRLLLRKQEIKELDEALHSLEFSRTDKLKSV 420
LK E D+T + L + ++ +L + +Q ++L+ L L+ + +++
Sbjct: 1369 GEWRLKYERAVREVDFTKKRLQQEFED---KLEVEQQNKRQLERRLGDLQADSEESQRAL 1425
Query: 421 LKKYAEVIEKTSYLMRPEVYRLINEEAMVMNYALLGNRKA----LAQLFVNLMESTLQQE 476
+ + T+ L +++ E V N+ L ++ L+Q LQ+E
Sbjct: 1426 QQLKKKCQRLTAELQDTKLHL---EGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQRE 1482
Query: 477 LDSRHRWQGLVD------------------TWKALKKEALLQSFS--EFMASESIHTPPA 516
R + L + T K + EA LQ S E S+
Sbjct: 1483 KLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKK 1542
Query: 517 VTKELEVMLKTQNVLQQRRLKHLCTICDLLPPSYSKTQLTEWHSSLNSLNKELDTYHVDC 576
++LE +K Q + L +L + + ++ E + +KE+++
Sbjct: 1543 QLRDLEAKVKDQ----EEELDEQAGTIQMLEQAKLRLEM-EMERMRQTHSKEMESRD--- 1594
Query: 577 MMWIRLLYEKTWQECLMHVQNCKKQLLDWKAFTEEEAETLVNQFFFQMVGALQGKVEEDL 636
+E Q+C+K+L + EEE E + KV +
Sbjct: 1595 ------------EEVEEARQSCQKKLKQMEVQLEEEYED-------------KQKVLREK 1629
Query: 637 ELLDKSFETLADQTEWQSSHLFKYFQEVVQLWEA--HQSELLVQEL-----------ELE 683
L+ TL+DQ + K ++ ++ +A ++L++ L +L+
Sbjct: 1630 RELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLK 1689
Query: 684 KRMEQH--------RQKHSLESQVQEAHLD---------RLLDQL-RQQSDKETLAFHLE 725
++E+ + + ++E ++++ HL L +QL R Q +K + LE
Sbjct: 1690 NQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLE 1749
Query: 726 KVKDYLKNMKSRYECFHTLLTKEVMEYPAIM--LKELNSYSSALSQY---------FFVR 774
+ ++ + + +++ ++++ + + L+E N L + F +
Sbjct: 1750 EDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQ 1809
Query: 775 EIFEQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGS-KEDMTRSEESISSGTSTARSV 833
+ +++L K R+ E + + +VK+L KE+M + E +
Sbjct: 1810 SMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENRE 1869
Query: 834 EEVEE-------ENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLE--------- 877
+E + + +EM +E +KK L + ES E + Q L+
Sbjct: 1870 KEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDL-ESLEAANQSLQADLKLAFKR 1928
Query: 878 --EMQVEREGSLNPSLNEENVKGQGEKKEESEEED 910
++Q E + NE+ + +G+ +SE ED
Sbjct: 1929 IGDLQAAIEDEMESDENEDLINSEGDSDVDSELED 1963
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 64.3 bits (155), Expect = 9e-10
Identities = 111/549 (20%), Positives = 233/549 (42%), Gaps = 68/549 (12%)
Query: 674 ELLVQELELEKRMEQHRQKHSLESQVQ-EAHLDRLLDQLRQQSDKETLAFHLEKVKDYLK 732
E V+E++ K+ Q + LE + Q + L+R L L+ S++ A L+++K +
Sbjct: 1376 ERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRA--LQQLKKKCQ 1433
Query: 733 NMKSRYECFHTLLTKEVMEYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQP 792
+ + + TK +E + EL Q F E+ + + + R+
Sbjct: 1434 RLTAELQD-----TKLHLEGQQVRNHELEK-----KQRRFDSELSQAHEEAQ-----REK 1478
Query: 793 EAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVE-EVEEENDQEMESFITEE 851
EK +++ L + K+ + + I+ T S+E E+++ + QE + E
Sbjct: 1479 LQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKD---EA 1535
Query: 852 VLGQQKKS--PLHAKMDESKE------GSIQGLEE--MQVEREGSLNPSLNEENVKGQGE 901
L + KK L AK+ + +E G+IQ LE+ +++E E + + ++ + E
Sbjct: 1536 SLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDE 1595
Query: 902 KKEESEEEDEKEEEEEEEKLEEEKEEK-----EAQEEQESLSVGEEEDKEEGLEEIYYED 956
+ EE+ + +K+ ++ E +LEEE E+K E +E + L+ ++ E E
Sbjct: 1596 EVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFES---EK 1652
Query: 957 MESFTISSGNTYFVFVPLEEEHCRKSHSTFS--AMFINDTSSAKFIEQVTIPSRLILEIK 1014
+ L +H + S + A N ++F + +R +E++
Sbjct: 1653 RLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVE 1712
Query: 1015 KQLFSEGGNFSPKEINSLCSRLEKEAARIELVESVIMLNMEKLENEYLDQANDVINKFES 1074
E + +I + LE++ +R++ ++ I +E E + N+++ K ++
Sbjct: 1713 ----IEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLE----EDQEDMNELMKKHKA 1764
Query: 1075 KFHNLSVDLIFIEKIQRLLTNLQVKIKCQVAKSNSQTNGLNFSLQQLQNKIKTCQESRGE 1134
S DL I +Q Q+ ++N + L LQ LQ++++ ++S +
Sbjct: 1765 AVAQASRDLAQINDLQ-----------AQLEEANKEKQELQEKLQALQSQVEFLEQSMVD 1813
Query: 1135 KTTVTTEELLSFVQTWKEKLSQRIQYLNCSLDRV-SMTELVFTNTILKDQEEDSDILTSS 1193
K+ V+ +E +L R+++ + R+ S+ + N +E D I +
Sbjct: 1814 KSLVSRQEAKI------RELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAEN 1867
Query: 1194 EALEEEAKL 1202
E+ +L
Sbjct: 1868 REKEQNKRL 1876
Score = 44.3 bits (103), Expect = 0.001
Identities = 85/404 (21%), Positives = 167/404 (41%), Gaps = 74/404 (18%)
Query: 599 KKQLLDWKAFTEEEAETLVNQF-FFQMVGALQGKVEEDLELLDKSFETLADQTEWQSSHL 657
KKQL D +A +++ E L Q QM+ + ++E ++E + ++ S +
Sbjct: 1541 KKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQT----------HSKEM 1590
Query: 658 FKYFQEVVQLWEAHQSELLVQELELEKRMEQHRQKHSLESQVQEAHLDRLLDQLRQQS-- 715
+EV + ++ Q +L E++LE+ E +QK E + E L L DQ+ ++
Sbjct: 1591 ESRDEEVEEARQSCQKKLKQMEVQLEEEYED-KQKVLREKRELEGKLATLSDQVNRRDFE 1649
Query: 716 DKETLAFHLEKVK----------DYLKNM---------------KSRYECFHTLLTKEVM 750
++ L L++ K D+LKN +S + C + ++ M
Sbjct: 1650 SEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAM 1709
Query: 751 EYPAIMLKELNSYSSALSQYFFVREIFEQNLAGEVIFKFRQPEAHE-----KPSQKRVKK 805
E + +++L + + +I + A E Q E +E + Q+ + +
Sbjct: 1710 E---VEIEDL---------HLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNE 1757
Query: 806 LRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMES---------FITEEVLGQQ 856
L KK K + ++ ++ +EE +E + E F+ + ++ +
Sbjct: 1758 LMKKH--KAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKS 1815
Query: 857 KKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEE 916
S AK+ E + + E QV+R SL L E K EE ++ E E
Sbjct: 1816 LVSRQEAKIRELE--TRLEFERTQVKRLESLASRLKENMEK----LTEERDQRIAAENRE 1869
Query: 917 EEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLE-EIYYEDMES 959
+E+ +++ ++ +EE L+ E E + E E+ E +E+
Sbjct: 1870 KEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEA 1913
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 63.5 bits (153), Expect = 2e-09
Identities = 49/208 (23%), Positives = 82/208 (39%), Gaps = 14/208 (6%)
Query: 778 EQNLAGEVIFKFRQPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVE 837
E+ G +F+ R + K ++R +K+R++Q + + E + EV
Sbjct: 153 ERGNDGVCLFRDRLEQLERK--RERERKMREQQKEQREQKERERRAEERRKEREARREVS 210
Query: 838 EENDQEMESFITEEVLGQQKKSPLHAKMD------------ESKEGSIQGLEEMQVEREG 885
+ E + + +SP + E K L ++Q +
Sbjct: 211 AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDS 270
Query: 886 SLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDK 945
S E + G EE EEE+E+EEEE E E+EE+E +EE+E EE
Sbjct: 271 ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEAS 330
Query: 946 EEGLEEIYYEDMESFTISSGNTYFVFVP 973
E+ EE+ E+M + + VP
Sbjct: 331 EQSAEEVSEEEMSEDEERENENHLLVVP 358
Score = 34.7 bits (78), Expect = 0.78
Identities = 32/144 (22%), Positives = 56/144 (38%), Gaps = 10/144 (6%)
Query: 804 KKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITEEVLGQQKKSPLHA 863
KK RK+Q K ++ R + S + R E E D ME I + SP
Sbjct: 20 KKRRKEQEEKAEIKRLKNS--DDRDSKRDSLEEGELRDHCMEITI--------RNSPYRR 69
Query: 864 KMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEE 923
+ G ++ ++ S ++ + + EKK +E E+E E + EE
Sbjct: 70 EDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREE 129
Query: 924 EKEEKEAQEEQESLSVGEEEDKEE 947
+ + + E Q+ + E + E
Sbjct: 130 QDKARREWERQKRREMAREHSRRE 153
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 62.8 bits (151), Expect = 3e-09
Identities = 48/158 (30%), Positives = 79/158 (50%), Gaps = 8/158 (5%)
Query: 797 KPSQKRVKKLRKKQGSKEDMTRSEESISSGT-----STARSVEEVEEENDQEMESFITEE 851
K K V+++ ++ +++ + EE++++ T S +E EE ++E E+ EE
Sbjct: 71 KVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEA---EE 127
Query: 852 VLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREGSLNPSLNEENVKGQGEKKEESEEEDE 911
KKSP+ A E KE + EE E E + + + G +KE S E++E
Sbjct: 128 EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 187
Query: 912 KEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGL 949
E+EE E + E E EE EA+EE++ EE +E L
Sbjct: 188 GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 225
Score = 54.3 bits (129), Expect = 1e-06
Identities = 41/128 (32%), Positives = 63/128 (49%), Gaps = 1/128 (0%)
Query: 833 VEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEMQVEREG-SLNPSL 891
VEE+ EE E E EE L + + +E KE + + EE + E E + S
Sbjct: 77 VEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSP 136
Query: 892 NEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEE 951
+ E++ E EEE+ +EEEEEE++ + + +E E+E S EE ++EEG E
Sbjct: 137 VKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETE 196
Query: 952 IYYEDMES 959
E E+
Sbjct: 197 AEAEGEEA 204
Score = 45.1 bits (105), Expect = 6e-04
Identities = 42/169 (24%), Positives = 76/169 (44%), Gaps = 16/169 (9%)
Query: 791 QPEAHEKPSQKRVKKLRKKQGSKEDMTRSEESISSGTSTARSVEEVEEENDQEMESFITE 850
+ EA + + K+ +K + E++ EE ++ VE+ E+ +S + E
Sbjct: 194 ETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADA-----KVEKPEKAKSPVPKSPVEE 248
Query: 851 EVLGQQKKSPLHAK------MDESKEGSIQGLEEMQVEREGS--LNPSLNEENVKGQGEK 902
+ KSP+ K +E + + VE +G ++ S EE K K
Sbjct: 249 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPK 308
Query: 903 KEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSVGEEEDKEEGLEE 951
E + + E + E+K EEEKE KEA +E++ V ++E+K + + E
Sbjct: 309 SPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEK---VEKKEEKPKDVPE 354
Score = 44.7 bits (104), Expect = 8e-04
Identities = 50/192 (26%), Positives = 80/192 (41%), Gaps = 12/192 (6%)
Query: 769 QYFFVREIFEQNLAGEVIFKFRQPEA-----HEKPSQKRVKKLRKKQGSKEDMTRSEESI 823
Q+ FV EI E+ + K EA E + +K + +E+ EE +
Sbjct: 73 QHKFVEEIIEETKVEDE--KSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEV 130
Query: 824 SSGTS----TARSVEEVEEENDQEMESFITEEVLGQQKKSPLHAKMDESKEGSIQGLEEM 879
++ S TA V+E E E ++E E EE + KS + KEGS + E
Sbjct: 131 AAKKSPVKATAPEVKEEEGEKEEE-EGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE 189
Query: 880 QVEREGSLNPSLNEENVKGQGEKKEESEEEDEKEEEEEEEKLEEEKEEKEAQEEQESLSV 939
Q E E E K + + +E+SEE KEE + K+E+ ++ K +
Sbjct: 190 QEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEK 249
Query: 940 GEEEDKEEGLEE 951
G+ + +EE
Sbjct: 250 GKSPVPKSPVEE 261
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.368
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,540,799
Number of Sequences: 37866
Number of extensions: 3058506
Number of successful extensions: 81787
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 928
Number of HSP's successfully gapped in prelim test: 1174
Number of HSP's that attempted gapping in prelim test: 24897
Number of HSP's gapped (non-prelim): 21316
length of query: 1646
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1530
effective length of database: 13,855,062
effective search space: 21198244860
effective search space used: 21198244860
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.