Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 54792100
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]
(1342 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens] 2813 0.0
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 1206 0.0
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 1205 0.0
gi|29725609 epidermal growth factor receptor isoform a precursor... 984 0.0
gi|54792096 erbB-2 isoform a [Homo sapiens] 921 0.0
gi|54792098 erbB-2 isoform b [Homo sapiens] 914 0.0
gi|41327736 epidermal growth factor receptor isoform d precursor... 591 e-168
gi|41327732 epidermal growth factor receptor isoform b precursor... 591 e-168
gi|41327734 epidermal growth factor receptor isoform c precursor... 352 1e-96
gi|54792102 erbB-3 isoform s precursor [Homo sapiens] 279 1e-74
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 193 1e-48
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 193 1e-48
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 176 1e-43
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 176 1e-43
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 176 1e-43
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 176 1e-43
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 175 2e-43
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 174 4e-43
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 172 3e-42
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 172 3e-42
gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 172 3e-42
gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo... 172 3e-42
gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 172 3e-42
gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 172 3e-42
gi|148596974 TXK tyrosine kinase [Homo sapiens] 170 7e-42
gi|153946393 macrophage stimulating 1 receptor precursor [Homo s... 170 1e-41
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 167 5e-41
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 167 5e-41
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 167 6e-41
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 167 6e-41
>gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]
Length = 1342
Score = 2813 bits (7292), Expect = 0.0
Identities = 1342/1342 (100%), Positives = 1342/1342 (100%)
Query: 1 MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM 60
MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM
Sbjct: 1 MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM 60
Query: 61 GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM 120
GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM
Sbjct: 61 GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM 120
Query: 121 LNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNG 180
LNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNG
Sbjct: 121 LNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNG 180
Query: 181 RSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQD 240
RSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQD
Sbjct: 181 RSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQD 240
Query: 241 TDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTS 300
TDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTS
Sbjct: 241 TDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTS 300
Query: 301 CVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGN 360
CVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGN
Sbjct: 301 CVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGN 360
Query: 361 LDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGG 420
LDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGG
Sbjct: 361 LDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGG 420
Query: 421 RSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEE 480
RSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEE
Sbjct: 421 RSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEE 480
Query: 481 RLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEP 540
RLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEP
Sbjct: 481 RLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEP 540
Query: 541 REFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPI 600
REFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPI
Sbjct: 541 REFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPI 600
Query: 601 YKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLG 660
YKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLG
Sbjct: 601 YKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLG 660
Query: 661 GTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVF 720
GTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVF
Sbjct: 661 GTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVF 720
Query: 721 GTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPG 780
GTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPG
Sbjct: 721 GTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPG 780
Query: 781 SSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNV 840
SSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNV
Sbjct: 781 SSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNV 840
Query: 841 LLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVT 900
LLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVT
Sbjct: 841 LLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVT 900
Query: 901 VWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKE 960
VWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKE
Sbjct: 901 VWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKE 960
Query: 961 LANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEED 1020
LANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEED
Sbjct: 961 LANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEED 1020
Query: 1021 NLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPR 1080
NLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPR
Sbjct: 1021 NLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPR 1080
Query: 1081 PVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLL 1140
PVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLL
Sbjct: 1081 PVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLL 1140
Query: 1141 TPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYM 1200
TPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYM
Sbjct: 1141 TPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYM 1200
Query: 1201 NRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDY 1260
NRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDY
Sbjct: 1201 NRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDY 1260
Query: 1261 EYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATD 1320
EYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATD
Sbjct: 1261 EYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATD 1320
Query: 1321 SAFDNPDYWHSRLFPKANAQRT 1342
SAFDNPDYWHSRLFPKANAQRT
Sbjct: 1321 SAFDNPDYWHSRLFPKANAQRT 1342
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 1206 bits (3120), Expect = 0.0
Identities = 623/1181 (52%), Positives = 792/1181 (67%), Gaps = 47/1181 (3%)
Query: 1 MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM 60
M+ L V L A + +SQ+VC GT N LS D E QY+ L K YE CEVVM
Sbjct: 1 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 60
Query: 61 GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM 120
GNLEI HN DLSFL+ +REVTGYVLVA+N+F LPL NLR++RGT++Y+ ++A+ +
Sbjct: 61 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 120
Query: 121 LNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRD---RDAEIVVK 177
LNY + + L++L L LTEIL+GGVY+++N LC+ DTI W+DIVR+ + +V
Sbjct: 121 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 180
Query: 178 DNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSG 237
+ C CH+ C GRCWGP CQTLT+T+CA QC+G C+GP + CCH ECAGGCSG
Sbjct: 181 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 240
Query: 238 PQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVD 297
P+DTDCFAC +FNDSGACV +CPQ VYN TFQLE N + KY YG CV CPHNFVVD
Sbjct: 241 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 300
Query: 298 QTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRF--QTVDSSNIDGFVNCT 355
+SCVRACP KMEV++NG+KMC+PC +CPKAC+G G+GS QTVDSSNID F+NCT
Sbjct: 301 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 360
Query: 356 KILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNL 415
KI GNL FL+TG++GDP++ I A+DPEKLNVFRTVREITG+LNIQSWPP+M +FSVFSNL
Sbjct: 361 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 420
Query: 416 TTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLR 475
TIGGR LY+ G SLLI+K +TSL F+SLKEISAG IYI+ N LCY+H++NWT L
Sbjct: 421 VTIGGRVLYS-GLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWT-TLF 478
Query: 476 GPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNF 535
+R+ I+ NR +C AEG VC+ LCSS GCWGPGP QCLSCR +SRG +C+ CN
Sbjct: 479 STINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNL 538
Query: 536 LNGEPREFAHEAECFSCHPECQPME-GTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVL 594
+GE REF + + C C P+C+ ME G TC+G G D C +C+HF+DGP+CV CP G+
Sbjct: 539 YDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQ 598
Query: 595 GAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCL------GQTLVLIGKTHLTMALTV 648
GA I+KY D EC PCH NCTQGC GP DC+ TL +T L +A V
Sbjct: 599 GANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPL-IAAGV 657
Query: 649 IAGLVVIFMMLGGTF-LYWRGRRIQNKRAMRRYLERGESIEPLDPSEKA-NKVLARIFKE 706
I GL ++ +++G TF +Y R + I+ KRA+RR+LE E +EPL PS A N+ RI KE
Sbjct: 658 IGGLFIL-VIVGLTFAVYVRRKSIKKKRALRRFLET-ELVEPLTPSGTAPNQAQLRILKE 715
Query: 707 TELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSL 766
TEL+++KVLGSG FGTV+KG+W+PEGE++KIPV IK++ + +G ++ D L + S+
Sbjct: 716 TELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASM 775
Query: 767 DHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLE 826
DH H+VRLLG+C ++QLVTQ +P G LL++V +H+ +G QLLLNW VQIAKGM YLE
Sbjct: 776 DHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLE 835
Query: 827 EHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFG 886
E +VHR+LAARNVL+KSP+ V++ DFG+A LL D+K+ K PIKWMALE IH+
Sbjct: 836 ERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYR 895
Query: 887 KYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVK 946
K+THQSDVWSYGVT+WELMTFG +PY G+ E+PDLLEKGERL QP ICTIDVYMVMVK
Sbjct: 896 KFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVK 955
Query: 947 CWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELE 1006
CWMID + RP FKELA EF+RMARDP RYLVI+ + + P P L+E +LE
Sbjct: 956 CWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKL-PSPNDSKFFQNLLDEEDLE 1014
Query: 1007 PELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNL---- 1062
+D + L + N+ S + NR S+ SP Y PM+
Sbjct: 1015 DMMDAEEYLVPQAFNIPPPIYTSRARI---DSNR---SEIGHSPPPAYTPMSGNQFVYRD 1068
Query: 1063 GESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSR 1122
G E VS P +P +A G+ AE+ + S C R
Sbjct: 1069 GGFAAEQGVS-----VPYRAPTSTIPEAPVAQ--------GATAEIFDD-SCCNGTLRKP 1114
Query: 1123 -SPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMP 1162
+P + DS+ +QR+S V E D GY+ P
Sbjct: 1115 VAPHVQEDSS--TQRYSADPTVFAPERSPRGELDEEGYMTP 1153
Score = 35.0 bits (79), Expect = 0.48
Identities = 23/90 (25%), Positives = 38/90 (42%), Gaps = 5/90 (5%)
Query: 1256 PDEDYEYMNRQRDGG-----GPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARL 1310
P E+ +++R+++G P A+ G A ++ E + Y +
Sbjct: 1165 PVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKN 1224
Query: 1311 KTLRSLEATDSAFDNPDYWHSRLFPKANAQ 1340
L E AFDNPDYW+ L P++ Q
Sbjct: 1225 NILSMPEKAKKAFDNPDYWNHSLPPRSTLQ 1254
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 1205 bits (3118), Expect = 0.0
Identities = 589/1036 (56%), Positives = 744/1036 (71%), Gaps = 20/1036 (1%)
Query: 1 MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM 60
M+ L V L A + +SQ+VC GT N LS D E QY+ L K YE CEVVM
Sbjct: 1 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM 60
Query: 61 GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM 120
GNLEI HN DLSFL+ +REVTGYVLVA+N+F LPL NLR++RGT++Y+ ++A+ +
Sbjct: 61 GNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF 120
Query: 121 LNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRD---RDAEIVVK 177
LNY + + L++L L LTEIL+GGVY+++N LC+ DTI W+DIVR+ + +V
Sbjct: 121 LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST 180
Query: 178 DNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSG 237
+ C CH+ C GRCWGP CQTLT+T+CA QC+G C+GP + CCH ECAGGCSG
Sbjct: 181 NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG 240
Query: 238 PQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVD 297
P+DTDCFAC +FNDSGACV +CPQ VYN TFQLE N + KY YG CV CPHNFVVD
Sbjct: 241 PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD 300
Query: 298 QTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRF--QTVDSSNIDGFVNCT 355
+SCVRACP KMEV++NG+KMC+PC +CPKAC+G G+GS QTVDSSNID F+NCT
Sbjct: 301 SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT 360
Query: 356 KILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNL 415
KI GNL FL+TG++GDP++ I A+DPEKLNVFRTVREITG+LNIQSWPP+M +FSVFSNL
Sbjct: 361 KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL 420
Query: 416 TTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLR 475
TIGGR LY+ G SLLI+K +TSL F+SLKEISAG IYI+ N LCY+H++NWT L
Sbjct: 421 VTIGGRVLYS-GLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWT-TLF 478
Query: 476 GPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNF 535
+R+ I+ NR +C AEG VC+ LCSS GCWGPGP QCLSCR +SRG +C+ CN
Sbjct: 479 STINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNL 538
Query: 536 LNGEPREFAHEAECFSCHPECQPME-GTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVL 594
+GE REF + + C C P+C+ ME G TC+G G D C +C+HF+DGP+CV CP G+
Sbjct: 539 YDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQ 598
Query: 595 GAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCL------GQTLVLIGKTHLTMALTV 648
GA I+KY D EC PCH NCTQGC GP DC+ TL +T L +A V
Sbjct: 599 GANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPL-IAAGV 657
Query: 649 IAGLVVIFMMLGGTF-LYWRGRRIQNKRAMRRYLERGESIEPLDPSEKA-NKVLARIFKE 706
I GL ++ +++G TF +Y R + I+ KRA+RR+LE E +EPL PS A N+ RI KE
Sbjct: 658 IGGLFIL-VIVGLTFAVYVRRKSIKKKRALRRFLET-ELVEPLTPSGTAPNQAQLRILKE 715
Query: 707 TELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSL 766
TEL+++KVLGSG FGTV+KG+W+PEGE++KIPV IK++ + +G ++ D L + S+
Sbjct: 716 TELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASM 775
Query: 767 DHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLE 826
DH H+VRLLG+C ++QLVTQ +P G LL++V +H+ +G QLLLNW VQIAKGM YLE
Sbjct: 776 DHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLE 835
Query: 827 EHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFG 886
E +VHR+LAARNVL+KSP+ V++ DFG+A LL D+K+ K PIKWMALE IH+
Sbjct: 836 ERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYR 895
Query: 887 KYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVK 946
K+THQSDVWSYGVT+WELMTFG +PY G+ E+PDLLEKGERL QP ICTIDVYMVMVK
Sbjct: 896 KFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVK 955
Query: 947 CWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELE 1006
CWMID + RP FKELA EF+RMARDP RYLVI+ + + P P L+E +LE
Sbjct: 956 CWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKL-PSPNDSKFFQNLLDEEDLE 1014
Query: 1007 PELDLDLDLEAEEDNL 1022
+D + L + N+
Sbjct: 1015 DMMDAEEYLVPQAFNI 1030
Score = 35.0 bits (79), Expect = 0.48
Identities = 23/90 (25%), Positives = 38/90 (42%), Gaps = 5/90 (5%)
Query: 1256 PDEDYEYMNRQRDGG-----GPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARL 1310
P E+ +++R+++G P A+ G A ++ E + Y +
Sbjct: 1149 PVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKN 1208
Query: 1311 KTLRSLEATDSAFDNPDYWHSRLFPKANAQ 1340
L E AFDNPDYW+ L P++ Q
Sbjct: 1209 NILSMPEKAKKAFDNPDYWNHSLPPRSTLQ 1238
>gi|29725609 epidermal growth factor receptor isoform a precursor
[Homo sapiens]
Length = 1210
Score = 984 bits (2543), Expect = 0.0
Identities = 479/1013 (47%), Positives = 653/1013 (64%), Gaps = 18/1013 (1%)
Query: 9 VLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLT 68
+L LL +L S + VC GT N L+ G E+ + +L +++ CEVV+GNLEI
Sbjct: 11 LLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYV 70
Query: 69 GHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSS 128
N DLSFL+ I+EV GYVL+A+N +PL NL+++RG Y+ +A+ V+ NY+ N +
Sbjct: 71 QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT 130
Query: 129 HALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRD---RDAEIVVKDNGRSCPP 185
L++L + L EIL G V N LC++++I WRDIV + + +++ SC
Sbjct: 131 -GLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQK 189
Query: 186 CHEVC-KGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCF 244
C C G CWG G E+CQ LTK ICA QC+G C G +P+ CCH++CA GC+GP+++DC
Sbjct: 190 CDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCL 249
Query: 245 ACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVV-DQTSCVR 303
CR F D C CP ++YN T+Q++ NP KY +G CV CP N+VV D SCVR
Sbjct: 250 VCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVR 309
Query: 304 ACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQT--VDSSNIDGFVNCTKILGNL 361
AC D E++++G++ C+ C G C K C G G G + ++++NI F NCT I G+L
Sbjct: 310 ACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDL 369
Query: 362 DFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGR 421
L GD + P LDP++L++ +TV+EITG+L IQ+WP + + F NL I GR
Sbjct: 370 HILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGR 429
Query: 422 SLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEER 481
+ + FSL ++ +LN+TSLG RSLKEIS G + IS N+ LCY +++NW K+ G + ++
Sbjct: 430 TKQHGQFSLAVV-SLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLF-GTSGQK 487
Query: 482 LDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPR 541
I NR C A G+VC LCS GCWGP P C+SCRN SRG CV CN L GEPR
Sbjct: 488 TKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPR 547
Query: 542 EFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGP-I 600
EF +EC CHPEC P TC G G D C QCAH+ DGPHCV +CP GV+G +
Sbjct: 548 EFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLV 607
Query: 601 YKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLG 660
+KY D + C CH NCT GC GP L+ C G ++A ++ L+++ ++
Sbjct: 608 WKYADAGHVCHLCHPNCTYGCTGPGLEGCPTN-----GPKIPSIATGMVGALLLLLVVAL 662
Query: 661 GTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKA-NKVLARIFKETELRKLKVLGSGV 719
G L+ R R I KR +RR L+ E +EPL PS +A N+ L RI KETE +K+KVLGSG
Sbjct: 663 GIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGA 722
Query: 720 FGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCP 779
FGTV+KG+WIPEGE +KIPV IK + + + ++ + + D + S+D+ H+ RLLG+C
Sbjct: 723 FGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICL 782
Query: 780 GSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARN 839
S++QL+TQ +P G LLD+VR+H+ +G Q LLNW VQIAKGM YLE+ +VHR+LAARN
Sbjct: 783 TSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARN 842
Query: 840 VLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGV 899
VL+K+P V++ DFG+A LL ++K+ K PIKWMALESI YTHQSDVWSYGV
Sbjct: 843 VLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGV 902
Query: 900 TVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFK 959
TVWELMTFG++PY G+ +E+ +LEKGERL QP ICTIDVYM+MVKCWMID + RP F+
Sbjct: 903 TVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFR 962
Query: 960 ELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLD 1012
EL EF++MARDP RYLVI+ + + P P ++E +++ +D D
Sbjct: 963 ELIIEFSKMARDPQRYLVIQGDERMHL-PSPTDSNFYRALMDEEDMDDVVDAD 1014
>gi|54792096 erbB-2 isoform a [Homo sapiens]
Length = 1255
Score = 921 bits (2380), Expect = 0.0
Identities = 470/983 (47%), Positives = 621/983 (63%), Gaps = 31/983 (3%)
Query: 25 SQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVT 84
S VC GT L + E L LY+ C+VV GNLE+ NA LSFLQ I+EV
Sbjct: 22 STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQ 81
Query: 85 GYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLN----YNTN-----SSHALRQLR 135
GYVL+A N+ +PL LR+VRGTQ+++ +A+ V+ N NT S LR+L+
Sbjct: 82 GYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQ 141
Query: 136 LTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDA---EIVVKDNGRSCPPCHEVCKG 192
L LTEIL GGV I++N +LC+ DTI W+DI + ++ + R+C PC +CKG
Sbjct: 142 LRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKG 201
Query: 193 -RCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFND 251
RCWG SEDCQ+LT+T+CA C C GP P CCH++CA GC+GP+ +DC AC HFN
Sbjct: 202 SRCWGESSEDCQSLTRTVCAGGC-ARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNH 260
Query: 252 SGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFV-VDQTSCVRACPPDKM 310
SG C CP + YN TF+ PNP +Y +G CV +CP+N++ D SC CP
Sbjct: 261 SGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQ 320
Query: 311 EVD-KNGLKMCEPCGGLCPKACEGTGSGS--RFQTVDSSNIDGFVNCTKILGNLDFLITG 367
EV ++G + CE C C + C G G + V S+NI F C KI G+L FL
Sbjct: 321 EVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPES 380
Query: 368 LNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRG 427
+GDP L PE+L VF T+ EITGYL I +WP + + SVF NL I GR L+N
Sbjct: 381 FDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGA 440
Query: 428 FSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHN 487
+SL + + L ++ LG RSL+E+ +G I N LC+ H++ W ++ R P + L N
Sbjct: 441 YSLTL-QGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTA-N 498
Query: 488 RPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEA 547
RP +CV EG C LC+ G CWGPGP QC++C + RG CV C L G PRE+ +
Sbjct: 499 RPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNAR 558
Query: 548 ECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKG--PIYKYPD 605
C CHPECQP G+ TC G +D C CAH++D P CV+ CP GV PI+K+PD
Sbjct: 559 HCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPD 618
Query: 606 VQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAG--LVVIFMMLGGTF 663
+ C+PC NCT C + + C + + LT ++ + G LVV+ ++ G
Sbjct: 619 EEGACQPCPINCTHSCVDLDDKGCPAEQRA----SPLTSIISAVVGILLVVVLGVVFGIL 674
Query: 664 LYWRGRRIQNKRAMRRYLERGESIEPLDPS-EKANKVLARIFKETELRKLKVLGSGVFGT 722
+ R ++I+ K MRR L+ E +EPL PS N+ RI KETELRK+KVLGSG FGT
Sbjct: 675 IKRRQQKIR-KYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGT 733
Query: 723 VHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSS 782
V+KG+WIP+GE++KIPV IKV+ + + ++ + + D + + ++ RLLG+C S+
Sbjct: 734 VYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTST 793
Query: 783 LQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLL 842
+QLVTQ +P G LLDHVR++RG LG Q LLNW +QIAKGM YLE+ +VHR+LAARNVL+
Sbjct: 794 VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLV 853
Query: 843 KSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVW 902
KSP+ V++ DFG+A LL D+ + K PIKWMALESI ++THQSDVWSYGVTVW
Sbjct: 854 KSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVW 913
Query: 903 ELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELA 962
ELMTFGA+PY G+ E+PDLLEKGERL QP ICTIDVYM+MVKCWMID RP F+EL
Sbjct: 914 ELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELV 973
Query: 963 NEFTRMARDPPRYLVIKRES-GP 984
+EF+RMARDP R++VI+ E GP
Sbjct: 974 SEFSRMARDPQRFVVIQNEDLGP 996
>gi|54792098 erbB-2 isoform b [Homo sapiens]
Length = 1225
Score = 914 bits (2363), Expect = 0.0
Identities = 465/972 (47%), Positives = 616/972 (63%), Gaps = 31/972 (3%)
Query: 36 LSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFS 95
L + E L LY+ C+VV GNLE+ NA LSFLQ I+EV GYVL+A N+
Sbjct: 3 LRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVR 62
Query: 96 TLPLPNLRVVRGTQVYDGKFAIFVMLN----YNTN-----SSHALRQLRLTQLTEILSGG 146
+PL LR+VRGTQ+++ +A+ V+ N NT S LR+L+L LTEIL GG
Sbjct: 63 QVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGG 122
Query: 147 VYIEKNDKLCHMDTIDWRDIVRDRDA---EIVVKDNGRSCPPCHEVCKG-RCWGPGSEDC 202
V I++N +LC+ DTI W+DI + ++ + R+C PC +CKG RCWG SEDC
Sbjct: 123 VLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDC 182
Query: 203 QTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQP 262
Q+LT+T+CA C C GP P CCH++CA GC+GP+ +DC AC HFN SG C CP
Sbjct: 183 QSLTRTVCAGGC-ARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPAL 241
Query: 263 LVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFV-VDQTSCVRACPPDKMEVD-KNGLKMC 320
+ YN TF+ PNP +Y +G CV +CP+N++ D SC CP EV ++G + C
Sbjct: 242 VTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRC 301
Query: 321 EPCGGLCPKACEGTGSGS--RFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPA 378
E C C + C G G + V S+NI F C KI G+L FL +GDP
Sbjct: 302 EKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAP 361
Query: 379 LDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNV 438
L PE+L VF T+ EITGYL I +WP + + SVF NL I GR L+N +SL + + L +
Sbjct: 362 LQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTL-QGLGI 420
Query: 439 TSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGK 498
+ LG RSL+E+ +G I N LC+ H++ W ++ R P + L NRP +CV EG
Sbjct: 421 SWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTA-NRPEDECVGEGL 479
Query: 499 VCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQP 558
C LC+ G CWGPGP QC++C + RG CV C L G PRE+ + C CHPECQP
Sbjct: 480 ACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQP 539
Query: 559 MEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKG--PIYKYPDVQNECRPCHEN 616
G+ TC G +D C CAH++D P CV+ CP GV PI+K+PD + C+PC N
Sbjct: 540 QNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPIN 599
Query: 617 CTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAG--LVVIFMMLGGTFLYWRGRRIQNK 674
CT C + + C + + LT ++ + G LVV+ ++ G + R ++I+ K
Sbjct: 600 CTHSCVDLDDKGCPAEQRA----SPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIR-K 654
Query: 675 RAMRRYLERGESIEPLDPS-EKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGE 733
MRR L+ E +EPL PS N+ RI KETELRK+KVLGSG FGTV+KG+WIP+GE
Sbjct: 655 YTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGE 714
Query: 734 SIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLG 793
++KIPV IKV+ + + ++ + + D + + ++ RLLG+C S++QLVTQ +P G
Sbjct: 715 NVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYG 774
Query: 794 SLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADF 853
LLDHVR++RG LG Q LLNW +QIAKGM YLE+ +VHR+LAARNVL+KSP+ V++ DF
Sbjct: 775 CLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDF 834
Query: 854 GVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYA 913
G+A LL D+ + K PIKWMALESI ++THQSDVWSYGVTVWELMTFGA+PY
Sbjct: 835 GLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYD 894
Query: 914 GLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPP 973
G+ E+PDLLEKGERL QP ICTIDVYM+MVKCWMID RP F+EL +EF+RMARDP
Sbjct: 895 GIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQ 954
Query: 974 RYLVIKRES-GP 984
R++VI+ E GP
Sbjct: 955 RFVVIQNEDLGP 966
>gi|41327736 epidermal growth factor receptor isoform d precursor
[Homo sapiens]
Length = 705
Score = 591 bits (1524), Expect = e-168
Identities = 280/620 (45%), Positives = 382/620 (61%), Gaps = 11/620 (1%)
Query: 9 VLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLT 68
+L LL +L S + VC GT N L+ G E+ + +L +++ CEVV+GNLEI
Sbjct: 11 LLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYV 70
Query: 69 GHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSS 128
N DLSFL+ I+EV GYVL+A+N +PL NL+++RG Y+ +A+ V+ NY+ N +
Sbjct: 71 QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT 130
Query: 129 HALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRD---RDAEIVVKDNGRSCPP 185
L++L + L EIL G V N LC++++I WRDIV + + +++ SC
Sbjct: 131 -GLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQK 189
Query: 186 CHEVC-KGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCF 244
C C G CWG G E+CQ LTK ICA QC+G C G +P+ CCH++CA GC+GP+++DC
Sbjct: 190 CDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCL 249
Query: 245 ACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVV-DQTSCVR 303
CR F D C CP ++YN T+Q++ NP KY +G CV CP N+VV D SCVR
Sbjct: 250 VCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVR 309
Query: 304 ACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQT--VDSSNIDGFVNCTKILGNL 361
AC D E++++G++ C+ C G C K C G G G + ++++NI F NCT I G+L
Sbjct: 310 ACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDL 369
Query: 362 DFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGR 421
L GD + P LDP++L++ +TV+EITG+L IQ+WP + + F NL I GR
Sbjct: 370 HILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGR 429
Query: 422 SLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEER 481
+ + FSL ++ +LN+TSLG RSLKEIS G + IS N+ LCY +++NW K+ G + ++
Sbjct: 430 TKQHGQFSLAVV-SLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLF-GTSGQK 487
Query: 482 LDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPR 541
I NR C A G+VC LCS GCWGP P C+SCRN SRG CV CN L GEPR
Sbjct: 488 TKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPR 547
Query: 542 EFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGP-I 600
EF +EC CHPEC P TC G G D C QCAH+ DGPHCV +CP GV+G +
Sbjct: 548 EFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLV 607
Query: 601 YKYPDVQNECRPCHENCTQG 620
+KY D + C CH NCT G
Sbjct: 608 WKYADAGHVCHLCHPNCTYG 627
Score = 50.4 bits (119), Expect = 1e-05
Identities = 70/318 (22%), Positives = 106/318 (33%), Gaps = 99/318 (31%)
Query: 326 LCP--------KACEGTGSG----SRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPW 373
LCP K C+GT + F+ S F NC +LGNL+ N D
Sbjct: 18 LCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYD-- 75
Query: 374 HKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIM 433
L+ +T++E+ GY+ I + NL I G Y ++L ++
Sbjct: 76 ----------LSFLKTIQEVAGYVLIAL---NTVERIPLENLQIIRGNMYYENSYALAVL 122
Query: 434 KNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDC 493
N + G LKE+ N Q H ++ ++ N P
Sbjct: 123 SNYDANKTG---LKELPM------RNLQEILHGAVRFS---------------NNPA--- 155
Query: 494 VAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFA-HEAECFSC 552
LC+ + + R+ + +FL+ +F H C C
Sbjct: 156 ---------LCNV---------ESIQWRD-------IVSSDFLSNMSMDFQNHLGSCQKC 190
Query: 553 HPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRP 612
P C +C G+G + C + C C K P ++C
Sbjct: 191 DPSCP----NGSCWGAGEENCQKLTKIICAQQCSGRCR-----GKSP--------SDC-- 231
Query: 613 CHENCTQGCKGPELQDCL 630
CH C GC GP DCL
Sbjct: 232 CHNQCAAGCTGPRESDCL 249
>gi|41327732 epidermal growth factor receptor isoform b precursor
[Homo sapiens]
Length = 628
Score = 591 bits (1524), Expect = e-168
Identities = 280/620 (45%), Positives = 382/620 (61%), Gaps = 11/620 (1%)
Query: 9 VLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLT 68
+L LL +L S + VC GT N L+ G E+ + +L +++ CEVV+GNLEI
Sbjct: 11 LLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYV 70
Query: 69 GHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSS 128
N DLSFL+ I+EV GYVL+A+N +PL NL+++RG Y+ +A+ V+ NY+ N +
Sbjct: 71 QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT 130
Query: 129 HALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRD---RDAEIVVKDNGRSCPP 185
L++L + L EIL G V N LC++++I WRDIV + + +++ SC
Sbjct: 131 -GLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQK 189
Query: 186 CHEVC-KGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCF 244
C C G CWG G E+CQ LTK ICA QC+G C G +P+ CCH++CA GC+GP+++DC
Sbjct: 190 CDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCL 249
Query: 245 ACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVV-DQTSCVR 303
CR F D C CP ++YN T+Q++ NP KY +G CV CP N+VV D SCVR
Sbjct: 250 VCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVR 309
Query: 304 ACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQT--VDSSNIDGFVNCTKILGNL 361
AC D E++++G++ C+ C G C K C G G G + ++++NI F NCT I G+L
Sbjct: 310 ACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDL 369
Query: 362 DFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGR 421
L GD + P LDP++L++ +TV+EITG+L IQ+WP + + F NL I GR
Sbjct: 370 HILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGR 429
Query: 422 SLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEER 481
+ + FSL ++ +LN+TSLG RSLKEIS G + IS N+ LCY +++NW K+ G + ++
Sbjct: 430 TKQHGQFSLAVV-SLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLF-GTSGQK 487
Query: 482 LDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPR 541
I NR C A G+VC LCS GCWGP P C+SCRN SRG CV CN L GEPR
Sbjct: 488 TKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPR 547
Query: 542 EFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGP-I 600
EF +EC CHPEC P TC G G D C QCAH+ DGPHCV +CP GV+G +
Sbjct: 548 EFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLV 607
Query: 601 YKYPDVQNECRPCHENCTQG 620
+KY D + C CH NCT G
Sbjct: 608 WKYADAGHVCHLCHPNCTYG 627
Score = 50.4 bits (119), Expect = 1e-05
Identities = 70/318 (22%), Positives = 106/318 (33%), Gaps = 99/318 (31%)
Query: 326 LCP--------KACEGTGSG----SRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPW 373
LCP K C+GT + F+ S F NC +LGNL+ N D
Sbjct: 18 LCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYD-- 75
Query: 374 HKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIM 433
L+ +T++E+ GY+ I + NL I G Y ++L ++
Sbjct: 76 ----------LSFLKTIQEVAGYVLIAL---NTVERIPLENLQIIRGNMYYENSYALAVL 122
Query: 434 KNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDC 493
N + G LKE+ N Q H ++ ++ N P
Sbjct: 123 SNYDANKTG---LKELPM------RNLQEILHGAVRFS---------------NNPA--- 155
Query: 494 VAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFA-HEAECFSC 552
LC+ + + R+ + +FL+ +F H C C
Sbjct: 156 ---------LCNV---------ESIQWRD-------IVSSDFLSNMSMDFQNHLGSCQKC 190
Query: 553 HPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRP 612
P C +C G+G + C + C C K P ++C
Sbjct: 191 DPSCP----NGSCWGAGEENCQKLTKIICAQQCSGRCR-----GKSP--------SDC-- 231
Query: 613 CHENCTQGCKGPELQDCL 630
CH C GC GP DCL
Sbjct: 232 CHNQCAAGCTGPRESDCL 249
>gi|41327734 epidermal growth factor receptor isoform c precursor
[Homo sapiens]
Length = 405
Score = 352 bits (903), Expect = 1e-96
Identities = 167/394 (42%), Positives = 241/394 (61%), Gaps = 8/394 (2%)
Query: 9 VLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLT 68
+L LL +L S + VC GT N L+ G E+ + +L +++ CEVV+GNLEI
Sbjct: 11 LLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYV 70
Query: 69 GHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSS 128
N DLSFL+ I+EV GYVL+A+N +PL NL+++RG Y+ +A+ V+ NY+ N +
Sbjct: 71 QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT 130
Query: 129 HALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRD---RDAEIVVKDNGRSCPP 185
L++L + L EIL G V N LC++++I WRDIV + + +++ SC
Sbjct: 131 -GLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQK 189
Query: 186 CHEVC-KGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCF 244
C C G CWG G E+CQ LTK ICA QC+G C G +P+ CCH++CA GC+GP+++DC
Sbjct: 190 CDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCL 249
Query: 245 ACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVV-DQTSCVR 303
CR F D C CP ++YN T+Q++ NP KY +G CV CP N+VV D SCVR
Sbjct: 250 VCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVR 309
Query: 304 ACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSG--SRFQTVDSSNIDGFVNCTKILGNL 361
AC D E++++G++ C+ C G C K C G G G +++++NI F NCT I G+L
Sbjct: 310 ACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDL 369
Query: 362 DFLITGLNGDPWHKIPALDPEKLNVFRTVREITG 395
L GD + P LDP++L++ +TV+EITG
Sbjct: 370 HILPVAFRGDSFTHTPPLDPQELDILKTVKEITG 403
Score = 88.6 bits (218), Expect = 4e-17
Identities = 73/282 (25%), Positives = 106/282 (37%), Gaps = 51/282 (18%)
Query: 326 LCP--------KACEGTGSG----SRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPW 373
LCP K C+GT + F+ S F NC +LGNL+ N D
Sbjct: 18 LCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYD-- 75
Query: 374 HKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIM 433
L+ +T++E+ GY+ I + NL I G Y ++L ++
Sbjct: 76 ----------LSFLKTIQEVAGYVLIAL---NTVERIPLENLQIIRGNMYYENSYALAVL 122
Query: 434 KNLNVTSLGF-----RSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNR 488
N + G R+L+EI G + S N LC S+ W ++ + +
Sbjct: 123 SNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQN 182
Query: 489 PRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAE 548
C + CDP C +G CWG G C +C C +G R ++
Sbjct: 183 HLGSC----QKCDPSCPNGSCWGAGEENCQKLTKI----ICAQQC---SGRCRG-KSPSD 230
Query: 549 CFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCP 590
C CH +C A C G C C FRD C +CP
Sbjct: 231 C--CHNQC-----AAGCTGPRESDCLVCRKFRDEATCKDTCP 265
>gi|54792102 erbB-3 isoform s precursor [Homo sapiens]
Length = 183
Score = 279 bits (713), Expect = 1e-74
Identities = 140/140 (100%), Positives = 140/140 (100%)
Query: 1 MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM 60
MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM
Sbjct: 1 MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM 60
Query: 61 GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM 120
GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM
Sbjct: 61 GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM 120
Query: 121 LNYNTNSSHALRQLRLTQLT 140
LNYNTNSSHALRQLRLTQLT
Sbjct: 121 LNYNTNSSHALRQLRLTQLT 140
Score = 44.7 bits (104), Expect = 6e-04
Identities = 33/121 (27%), Positives = 57/121 (47%), Gaps = 27/121 (22%)
Query: 326 LCPKACEG---TGSG-SRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDP 381
+CP G TG +++QT+ + C ++GNL+ ++TG N D
Sbjct: 28 VCPGTLNGLSVTGDAENQYQTLYKL----YERCEVVMGNLEIVLTGHNAD---------- 73
Query: 382 EKLNVFRTVREITGYLNIQSWPPHMHNFSV--FSNLTTIGGRSLYNRGFSLLIMKNLNVT 439
L+ + +RE+TGY+ + M+ FS NL + G +Y+ F++ +M N N
Sbjct: 74 --LSFLQWIREVTGYVLVA-----MNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTN 126
Query: 440 S 440
S
Sbjct: 127 S 127
>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo
sapiens]
Length = 1038
Score = 193 bits (490), Expect = 1e-48
Identities = 105/266 (39%), Positives = 159/266 (59%), Gaps = 5/266 (1%)
Query: 700 LARIFKETELRKLKVLGSGVFGTVHKGVW-IPEGESIKIPV-CIKVIEDKSGRQSFQAVT 757
L + E +LR L+ LG G FG V +G W P G+++ + V C+K + S ++
Sbjct: 117 LTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKP-DVLSQPEAMDDFI 175
Query: 758 DHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQ 817
+ A+ SLDH +++RL G+ +++VT+ PLGSLLD +R+H+G L + VQ
Sbjct: 176 REVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQ 235
Query: 818 IAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPP-DDKQLLYSEAKTPIK 876
+A+GM YLE +HR+LAARN+LL + V++ DFG+ LP DD ++ K P
Sbjct: 236 VAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFA 295
Query: 877 WMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEK-GERLAQPQI 935
W A ES+ ++H SD W +GVT+WE+ T+G EP+ GL +++ ++K GERL +P+
Sbjct: 296 WCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPED 355
Query: 936 CTIDVYMVMVKCWMIDENIRPTFKEL 961
C D+Y VMV+CW RPTF L
Sbjct: 356 CPQDIYNVMVQCWAHKPEDRPTFVAL 381
>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo
sapiens]
Length = 1086
Score = 193 bits (490), Expect = 1e-48
Identities = 105/266 (39%), Positives = 159/266 (59%), Gaps = 5/266 (1%)
Query: 700 LARIFKETELRKLKVLGSGVFGTVHKGVW-IPEGESIKIPV-CIKVIEDKSGRQSFQAVT 757
L + E +LR L+ LG G FG V +G W P G+++ + V C+K + S ++
Sbjct: 180 LTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKP-DVLSQPEAMDDFI 238
Query: 758 DHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQ 817
+ A+ SLDH +++RL G+ +++VT+ PLGSLLD +R+H+G L + VQ
Sbjct: 239 REVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQ 298
Query: 818 IAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPP-DDKQLLYSEAKTPIK 876
+A+GM YLE +HR+LAARN+LL + V++ DFG+ LP DD ++ K P
Sbjct: 299 VAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFA 358
Query: 877 WMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEK-GERLAQPQI 935
W A ES+ ++H SD W +GVT+WE+ T+G EP+ GL +++ ++K GERL +P+
Sbjct: 359 WCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPED 418
Query: 936 CTIDVYMVMVKCWMIDENIRPTFKEL 961
C D+Y VMV+CW RPTF L
Sbjct: 419 CPQDIYNVMVQCWAHKPEDRPTFVAL 444
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 176 bits (446), Expect = 1e-43
Identities = 121/379 (31%), Positives = 195/379 (51%), Gaps = 24/379 (6%)
Query: 705 KETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIG 764
+ T++ LG G +G V+ GVW + + V +K +++ + + +
Sbjct: 269 ERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDT--MEVEEFLKEAAVMK 322
Query: 765 SLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVRQ-HRGALGPQLLLNWGVQIAKGM 822
+ H ++V+LLG+C +VT+Y+P G+LLD++R+ +R + +LL QI+ M
Sbjct: 323 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 382
Query: 823 YYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALES 882
YLE+ +HR+LAARN L+ V+VADFG++ L+ D ++ AK PIKW A ES
Sbjct: 383 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPES 441
Query: 883 IHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYM 942
+ + ++ +SDVW++GV +WE+ T+G PY G+ L++V DLLEKG R+ QP+ C VY
Sbjct: 442 LAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE 501
Query: 943 VMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPG---PEPHGLTNKK 999
+M CW RP+F E F M D + E G + P L
Sbjct: 502 LMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILP 561
Query: 1000 LEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQ 1059
+ L+ +++ ++E +D T SA SL G + RG+Q+ S S +P Q
Sbjct: 562 SKTRTLKKQVENKENIEGAQD----ATENSASSLAPGFI---RGAQA--SSGSPALPRKQ 612
Query: 1060 GNLGESCQESAVSGSSERC 1078
+ S S + + E C
Sbjct: 613 RDKSPS---SLLEDAKETC 628
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 176 bits (446), Expect = 1e-43
Identities = 121/379 (31%), Positives = 195/379 (51%), Gaps = 24/379 (6%)
Query: 705 KETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIG 764
+ T++ LG G +G V+ GVW + + V +K +++ + + +
Sbjct: 284 ERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDT--MEVEEFLKEAAVMK 337
Query: 765 SLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVRQ-HRGALGPQLLLNWGVQIAKGM 822
+ H ++V+LLG+C +VT+Y+P G+LLD++R+ +R + +LL QI+ M
Sbjct: 338 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 397
Query: 823 YYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALES 882
YLE+ +HR+LAARN L+ V+VADFG++ L+ D ++ AK PIKW A ES
Sbjct: 398 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPES 456
Query: 883 IHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYM 942
+ + ++ +SDVW++GV +WE+ T+G PY G+ L++V DLLEKG R+ QP+ C VY
Sbjct: 457 LAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE 516
Query: 943 VMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPG---PEPHGLTNKK 999
+M CW RP+F E F M D + E G + P L
Sbjct: 517 LMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILP 576
Query: 1000 LEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQ 1059
+ L+ +++ ++E +D T SA SL G + RG+Q+ S S +P Q
Sbjct: 577 SKTRTLKKQVENKENIEGAQD----ATENSASSLAPGFI---RGAQA--SSGSPALPRKQ 627
Query: 1060 GNLGESCQESAVSGSSERC 1078
+ S S + + E C
Sbjct: 628 RDKSPS---SLLEDAKETC 643
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 176 bits (446), Expect = 1e-43
Identities = 121/379 (31%), Positives = 195/379 (51%), Gaps = 24/379 (6%)
Query: 705 KETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIG 764
+ T++ LG G +G V+ GVW + + V +K +++ + + +
Sbjct: 269 ERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDT--MEVEEFLKEAAVMK 322
Query: 765 SLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVRQ-HRGALGPQLLLNWGVQIAKGM 822
+ H ++V+LLG+C +VT+Y+P G+LLD++R+ +R + +LL QI+ M
Sbjct: 323 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 382
Query: 823 YYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALES 882
YLE+ +HR+LAARN L+ V+VADFG++ L+ D ++ AK PIKW A ES
Sbjct: 383 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPES 441
Query: 883 IHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYM 942
+ + ++ +SDVW++GV +WE+ T+G PY G+ L++V DLLEKG R+ QP+ C VY
Sbjct: 442 LAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE 501
Query: 943 VMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPG---PEPHGLTNKK 999
+M CW RP+F E F M D + E G + P L
Sbjct: 502 LMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILP 561
Query: 1000 LEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQ 1059
+ L+ +++ ++E +D T SA SL G + RG+Q+ S S +P Q
Sbjct: 562 SKTRTLKKQVENKENIEGAQD----ATENSASSLAPGFI---RGAQA--SSGSPALPRKQ 612
Query: 1060 GNLGESCQESAVSGSSERC 1078
+ S S + + E C
Sbjct: 613 RDKSPS---SLLEDAKETC 628
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 176 bits (446), Expect = 1e-43
Identities = 121/379 (31%), Positives = 195/379 (51%), Gaps = 24/379 (6%)
Query: 705 KETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIG 764
+ T++ LG G +G V+ GVW + + V +K +++ + + +
Sbjct: 248 ERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDT--MEVEEFLKEAAVMK 301
Query: 765 SLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVRQ-HRGALGPQLLLNWGVQIAKGM 822
+ H ++V+LLG+C +VT+Y+P G+LLD++R+ +R + +LL QI+ M
Sbjct: 302 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 361
Query: 823 YYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALES 882
YLE+ +HR+LAARN L+ V+VADFG++ L+ D ++ AK PIKW A ES
Sbjct: 362 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPES 420
Query: 883 IHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYM 942
+ + ++ +SDVW++GV +WE+ T+G PY G+ L++V DLLEKG R+ QP+ C VY
Sbjct: 421 LAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE 480
Query: 943 VMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPG---PEPHGLTNKK 999
+M CW RP+F E F M D + E G + P L
Sbjct: 481 LMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILP 540
Query: 1000 LEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQ 1059
+ L+ +++ ++E +D T SA SL G + RG+Q+ S S +P Q
Sbjct: 541 SKTRTLKKQVENKENIEGAQD----ATENSASSLAPGFI---RGAQA--SSGSPALPRKQ 591
Query: 1060 GNLGESCQESAVSGSSERC 1078
+ S S + + E C
Sbjct: 592 RDKSPS---SLLEDAKETC 607
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 175 bits (444), Expect = 2e-43
Identities = 97/269 (36%), Positives = 154/269 (57%), Gaps = 9/269 (3%)
Query: 705 KETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIG 764
+ T++ LG G +G V+ GVW + + V +K +++ + + +
Sbjct: 263 ERTDITMKHKLGGGQYGEVYVGVW----KKYSLTVAVKTLKEDT--MEVEEFLKEAAVMK 316
Query: 765 SLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVRQ-HRGALGPQLLLNWGVQIAKGM 822
+ H ++V+LLG+C +VT+Y+P G+LLD++R+ +R + +LL QI+ M
Sbjct: 317 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 376
Query: 823 YYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALES 882
YLE+ +HR+LAARN L+ V+VADFG++ L+ D ++ AK PIKW A ES
Sbjct: 377 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPES 435
Query: 883 IHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYM 942
+ + ++ +SDVW++GV +WE+ T+G PY G+ L++V DLLEKG R+ QP+ C VY
Sbjct: 436 LAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYE 495
Query: 943 VMVKCWMIDENIRPTFKELANEFTRMARD 971
+M CW RP+F E F M D
Sbjct: 496 LMRACWKWSPADRPSFAETHQAFETMFHD 524
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 174 bits (442), Expect = 4e-43
Identities = 117/358 (32%), Positives = 181/358 (50%), Gaps = 21/358 (5%)
Query: 632 QTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRR--YLERGESIEP 689
QTL G +L + V G+V++ ++ G F R R+ Q R Y + E ++P
Sbjct: 525 QTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKP 584
Query: 690 L----------DPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPV 739
L DP++ K I R+ KV+G+G FG V+KG+ ++PV
Sbjct: 585 LKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQ-KVIGAGEFGEVYKGMLKTSSGKKEVPV 643
Query: 740 CIKVIEDKSGRQSFQAVT--DHMLAIGSLDHAHIVRLLGLCPG-SSLQLVTQYLPLGSLL 796
IK + K+G Q V +G H +I+RL G+ + ++T+Y+ G+L
Sbjct: 644 AIKTL--KAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALD 701
Query: 797 DHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVA 856
+R+ G L+ IA GM YL VHR+LAARN+L+ S +V+DFG++
Sbjct: 702 KFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLS 761
Query: 857 DLLPPDDKQLLY--SEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAG 914
+L DD + Y S K PI+W A E+I + K+T SDVWS+G+ +WE+MT+G PY
Sbjct: 762 RVLE-DDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWE 820
Query: 915 LRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDP 972
L EV + G RL P C +Y +M++CW + RP F ++ + ++ R P
Sbjct: 821 LSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAP 878
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 172 bits (435), Expect = 3e-42
Identities = 93/281 (33%), Positives = 163/281 (58%), Gaps = 9/281 (3%)
Query: 705 KETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIG 764
+ T++ LG G +G V++GVW + + V +K +++ + + +
Sbjct: 238 ERTDITMKHKLGGGQYGEVYEGVW----KKYSLTVAVKTLKEDT--MEVEEFLKEAAVMK 291
Query: 765 SLDHAHIVRLLGLCPGSS-LQLVTQYLPLGSLLDHVRQ-HRGALGPQLLLNWGVQIAKGM 822
+ H ++V+LLG+C ++T+++ G+LLD++R+ +R + +LL QI+ M
Sbjct: 292 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 351
Query: 823 YYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALES 882
YLE+ +HR+LAARN L+ V+VADFG++ L+ D ++ AK PIKW A ES
Sbjct: 352 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPES 410
Query: 883 IHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYM 942
+ + K++ +SDVW++GV +WE+ T+G PY G+ L++V +LLEK R+ +P+ C VY
Sbjct: 411 LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYE 470
Query: 943 VMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESG 983
+M CW + + RP+F E+ F M ++ +++E G
Sbjct: 471 LMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELG 511
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 172 bits (435), Expect = 3e-42
Identities = 93/281 (33%), Positives = 163/281 (58%), Gaps = 9/281 (3%)
Query: 705 KETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIG 764
+ T++ LG G +G V++GVW + + V +K +++ + + +
Sbjct: 257 ERTDITMKHKLGGGQYGEVYEGVW----KKYSLTVAVKTLKEDT--MEVEEFLKEAAVMK 310
Query: 765 SLDHAHIVRLLGLCPGSS-LQLVTQYLPLGSLLDHVRQ-HRGALGPQLLLNWGVQIAKGM 822
+ H ++V+LLG+C ++T+++ G+LLD++R+ +R + +LL QI+ M
Sbjct: 311 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 370
Query: 823 YYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALES 882
YLE+ +HR+LAARN L+ V+VADFG++ L+ D ++ AK PIKW A ES
Sbjct: 371 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPES 429
Query: 883 IHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYM 942
+ + K++ +SDVW++GV +WE+ T+G PY G+ L++V +LLEK R+ +P+ C VY
Sbjct: 430 LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYE 489
Query: 943 VMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESG 983
+M CW + + RP+F E+ F M ++ +++E G
Sbjct: 490 LMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELG 530
>gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 172 bits (435), Expect = 3e-42
Identities = 101/297 (34%), Positives = 166/297 (55%), Gaps = 12/297 (4%)
Query: 673 NKRAMRRYLERGESIEPLDPSEKANKVLAR-------IFKETELRKLKVLGSGVFGTVHK 725
N A R +L SIE +E ++ L R I +E + ++LG G FG V++
Sbjct: 383 NLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLN-RILGEGFFGEVYE 441
Query: 726 GVWIP-EGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQ 784
GV+ +GE KI V +K + + + + + +LDH HIV+L+G+
Sbjct: 442 GVYTNHKGE--KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTW 499
Query: 785 LVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS 844
++ + P G L ++ +++ +L L+ + +QI K M YLE VHR++A RN+L+ S
Sbjct: 500 IIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVAS 559
Query: 845 PSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWEL 904
P V++ DFG++ + +D S + PIKWM+ ESI+F ++T SDVW + V +WE+
Sbjct: 560 PECVKLGDFGLSRYIEDEDYYKA-SVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEI 618
Query: 905 MTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKEL 961
++FG +P+ L +V +LEKG+RL +P +C +Y +M +CW D + RP F EL
Sbjct: 619 LSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 675
>gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo
sapiens]
Length = 967
Score = 172 bits (435), Expect = 3e-42
Identities = 101/297 (34%), Positives = 166/297 (55%), Gaps = 12/297 (4%)
Query: 673 NKRAMRRYLERGESIEPLDPSEKANKVLAR-------IFKETELRKLKVLGSGVFGTVHK 725
N A R +L SIE +E ++ L R I +E + ++LG G FG V++
Sbjct: 383 NLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLN-RILGEGFFGEVYE 441
Query: 726 GVWIP-EGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQ 784
GV+ +GE KI V +K + + + + + +LDH HIV+L+G+
Sbjct: 442 GVYTNHKGE--KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTW 499
Query: 785 LVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS 844
++ + P G L ++ +++ +L L+ + +QI K M YLE VHR++A RN+L+ S
Sbjct: 500 IIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVAS 559
Query: 845 PSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWEL 904
P V++ DFG++ + +D S + PIKWM+ ESI+F ++T SDVW + V +WE+
Sbjct: 560 PECVKLGDFGLSRYIEDEDYYKA-SVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEI 618
Query: 905 MTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKEL 961
++FG +P+ L +V +LEKG+RL +P +C +Y +M +CW D + RP F EL
Sbjct: 619 LSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 675
>gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 172 bits (435), Expect = 3e-42
Identities = 101/297 (34%), Positives = 166/297 (55%), Gaps = 12/297 (4%)
Query: 673 NKRAMRRYLERGESIEPLDPSEKANKVLAR-------IFKETELRKLKVLGSGVFGTVHK 725
N A R +L SIE +E ++ L R I +E + ++LG G FG V++
Sbjct: 383 NLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLN-RILGEGFFGEVYE 441
Query: 726 GVWIP-EGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQ 784
GV+ +GE KI V +K + + + + + +LDH HIV+L+G+
Sbjct: 442 GVYTNHKGE--KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTW 499
Query: 785 LVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS 844
++ + P G L ++ +++ +L L+ + +QI K M YLE VHR++A RN+L+ S
Sbjct: 500 IIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVAS 559
Query: 845 PSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWEL 904
P V++ DFG++ + +D S + PIKWM+ ESI+F ++T SDVW + V +WE+
Sbjct: 560 PECVKLGDFGLSRYIEDEDYYKA-SVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEI 618
Query: 905 MTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKEL 961
++FG +P+ L +V +LEKG+RL +P +C +Y +M +CW D + RP F EL
Sbjct: 619 LSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 675
>gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 172 bits (435), Expect = 3e-42
Identities = 101/297 (34%), Positives = 166/297 (55%), Gaps = 12/297 (4%)
Query: 673 NKRAMRRYLERGESIEPLDPSEKANKVLAR-------IFKETELRKLKVLGSGVFGTVHK 725
N A R +L SIE +E ++ L R I +E + ++LG G FG V++
Sbjct: 383 NLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLN-RILGEGFFGEVYE 441
Query: 726 GVWIP-EGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQ 784
GV+ +GE KI V +K + + + + + +LDH HIV+L+G+
Sbjct: 442 GVYTNHKGE--KINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTW 499
Query: 785 LVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKS 844
++ + P G L ++ +++ +L L+ + +QI K M YLE VHR++A RN+L+ S
Sbjct: 500 IIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVAS 559
Query: 845 PSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWEL 904
P V++ DFG++ + +D S + PIKWM+ ESI+F ++T SDVW + V +WE+
Sbjct: 560 PECVKLGDFGLSRYIEDEDYYKA-SVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEI 618
Query: 905 MTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKEL 961
++FG +P+ L +V +LEKG+RL +P +C +Y +M +CW D + RP F EL
Sbjct: 619 LSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 675
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 170 bits (431), Expect = 7e-42
Identities = 98/264 (37%), Positives = 149/264 (56%), Gaps = 9/264 (3%)
Query: 707 TELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSL 766
+EL +K +GSG FG VH G W I V IK I + G S + + + L
Sbjct: 269 SELAFIKEIGSGQFGVVHLGEWRSH-----IQVAIKAINE--GSMSEEDFIEEAKVMMKL 321
Query: 767 DHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYL 825
H+ +V+L G+C L +VT+++ G LL+++R+++G L ++LL+ I +GM YL
Sbjct: 322 SHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYL 381
Query: 826 EEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHF 885
E +G +HR+LAARN L+ S V+++DFG+ + DD+ + AK PIKW E F
Sbjct: 382 ERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVL-DDEYVSSFGAKFPIKWSPPEVFLF 440
Query: 886 GKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMV 945
KY+ +SDVWS+GV +WE+ T G P+ +V + + +G RL +P + + +Y VM
Sbjct: 441 NKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMY 500
Query: 946 KCWMIDENIRPTFKELANEFTRMA 969
CW RPTF EL T +A
Sbjct: 501 SCWHEKPEGRPTFAELLRAVTEIA 524
>gi|153946393 macrophage stimulating 1 receptor precursor [Homo
sapiens]
Length = 1400
Score = 170 bits (430), Expect = 1e-41
Identities = 95/256 (37%), Positives = 151/256 (58%), Gaps = 5/256 (1%)
Query: 713 KVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIV 772
+V+G G FG V+ G +I + ++ +I IK + + Q +A L + L+H +++
Sbjct: 1086 RVIGKGHFGVVYHGEYIDQAQN-RIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVL 1144
Query: 773 RLLGLC--PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGM 830
L+G+ P ++ Y+ G LL +R + + L+++G+Q+A+GM YL E
Sbjct: 1145 ALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKF 1204
Query: 831 VHRNLAARNVLLKSPSQVQVADFGVA-DLLPPDDKQLL-YSEAKTPIKWMALESIHFGKY 888
VHR+LAARN +L V+VADFG+A D+L + + + A+ P+KWMALES+ ++
Sbjct: 1205 VHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRF 1264
Query: 889 THQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCW 948
T +SDVWS+GV +WEL+T GA PY + ++ L +G RL QP+ C +Y VM +CW
Sbjct: 1265 TTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCW 1324
Query: 949 MIDENIRPTFKELANE 964
D +RPTF+ L E
Sbjct: 1325 EADPAVRPTFRVLVGE 1340
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 167 bits (424), Expect = 5e-41
Identities = 100/275 (36%), Positives = 160/275 (58%), Gaps = 16/275 (5%)
Query: 691 DPSEKANKVLARIFKETELRKL--KVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKS 748
DP E K ++ + +L L K LGSG FGTV KG + + + + V +K++++++
Sbjct: 331 DPEEIRPK---EVYLDRKLLTLEDKELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEA 385
Query: 749 GRQSFQAVTDHMLA----IGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRG 804
A+ D +LA + LD+ +IVR++G+C S LV + LG L +++Q+R
Sbjct: 386 NDP---ALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRH 442
Query: 805 ALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDK 864
++ Q++ GM YLEE VHR+LAARNVLL + +++DFG++ L D+
Sbjct: 443 VKDKNII-ELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADEN 501
Query: 865 QL-LYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDL 923
+ K P+KW A E I++ K++ +SDVWS+GV +WE ++G +PY G++ +EV +
Sbjct: 502 YYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM 561
Query: 924 LEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTF 958
LEKGER+ P C ++Y +M CW D RP F
Sbjct: 562 LEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 596
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 167 bits (424), Expect = 5e-41
Identities = 100/275 (36%), Positives = 160/275 (58%), Gaps = 16/275 (5%)
Query: 691 DPSEKANKVLARIFKETELRKL--KVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKS 748
DP E K ++ + +L L K LGSG FGTV KG + + + + V +K++++++
Sbjct: 354 DPEEIRPK---EVYLDRKLLTLEDKELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEA 408
Query: 749 GRQSFQAVTDHMLA----IGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRG 804
A+ D +LA + LD+ +IVR++G+C S LV + LG L +++Q+R
Sbjct: 409 NDP---ALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRH 465
Query: 805 ALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDK 864
++ Q++ GM YLEE VHR+LAARNVLL + +++DFG++ L D+
Sbjct: 466 VKDKNII-ELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADEN 524
Query: 865 QL-LYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDL 923
+ K P+KW A E I++ K++ +SDVWS+GV +WE ++G +PY G++ +EV +
Sbjct: 525 YYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM 584
Query: 924 LEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTF 958
LEKGER+ P C ++Y +M CW D RP F
Sbjct: 585 LEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 167 bits (423), Expect = 6e-41
Identities = 94/292 (32%), Positives = 154/292 (52%), Gaps = 14/292 (4%)
Query: 713 KVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIV 772
+ +G G FG VH+G+++ E+ + V IK ++ + + L + DH HIV
Sbjct: 448 RCIGEGQFGDVHQGIYMSP-ENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIV 506
Query: 773 RLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVH 832
+L+G+ + + ++ + LG L ++ + +L L+ + Q++ + YLE VH
Sbjct: 507 KLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVH 566
Query: 833 RNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQS 892
R++AARNVL+ S V++ DFG++ + D S+ K PIKWMA ESI+F ++T S
Sbjct: 567 RDIAARNVLVSSNDCVKLGDFGLSRYME-DSTYYKASKGKLPIKWMAPESINFRRFTSAS 625
Query: 893 DVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDE 952
DVW +GV +WE++ G +P+ G++ +V +E GERL P C +Y +M KCW D
Sbjct: 626 DVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDP 685
Query: 953 NIRPTFKEL------------ANEFTRMARDPPRYLVIKRESGPGIAPGPEP 992
+ RP F EL A + RM + R + +SG P+P
Sbjct: 686 SRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKP 737
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 167 bits (423), Expect = 6e-41
Identities = 94/292 (32%), Positives = 154/292 (52%), Gaps = 14/292 (4%)
Query: 713 KVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIV 772
+ +G G FG VH+G+++ E+ + V IK ++ + + L + DH HIV
Sbjct: 426 RCIGEGQFGDVHQGIYMSP-ENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIV 484
Query: 773 RLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVH 832
+L+G+ + + ++ + LG L ++ + +L L+ + Q++ + YLE VH
Sbjct: 485 KLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVH 544
Query: 833 RNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQS 892
R++AARNVL+ S V++ DFG++ + D S+ K PIKWMA ESI+F ++T S
Sbjct: 545 RDIAARNVLVSSNDCVKLGDFGLSRYME-DSTYYKASKGKLPIKWMAPESINFRRFTSAS 603
Query: 893 DVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDE 952
DVW +GV +WE++ G +P+ G++ +V +E GERL P C +Y +M KCW D
Sbjct: 604 DVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDP 663
Query: 953 NIRPTFKEL------------ANEFTRMARDPPRYLVIKRESGPGIAPGPEP 992
+ RP F EL A + RM + R + +SG P+P
Sbjct: 664 SRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKP 715
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,954,255
Number of Sequences: 37866
Number of extensions: 3302875
Number of successful extensions: 13058
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 512
Number of HSP's successfully gapped in prelim test: 421
Number of HSP's that attempted gapping in prelim test: 10490
Number of HSP's gapped (non-prelim): 1874
length of query: 1342
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1228
effective length of database: 13,930,794
effective search space: 17107015032
effective search space used: 17107015032
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.