Search of human proteins with 5453976

Search of human proteins with 5453976

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5453976 protein kinase C, theta [Homo sapiens]
         (706 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5453976 protein kinase C, theta [Homo sapiens]                    1480   0.0  
gi|47157325 protein kinase C, delta [Homo sapiens]                    907   0.0  
gi|31377782 protein kinase C, delta [Homo sapiens]                    907   0.0  
gi|4885563 protein kinase C, epsilon [Homo sapiens]                   560   e-159
gi|28557781 protein kinase C, eta [Homo sapiens]                      541   e-154
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]           395   e-110
gi|4506067 protein kinase C, alpha [Homo sapiens]                     387   e-107
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]           382   e-106
gi|13384594 protein kinase C, gamma [Homo sapiens]                    363   e-100
gi|133908623 protein kinase C, iota [Homo sapiens]                    336   4e-92
gi|5453974 protein kinase N2 [Homo sapiens]                           332   7e-91
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]           330   3e-90
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]                321   1e-87
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]                321   1e-87
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]           307   2e-83
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]           307   2e-83
gi|4502023 AKT2 kinase [Homo sapiens]                                 300   3e-81
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       299   7e-81
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      298   1e-80
gi|62241015 AKT1 kinase [Homo sapiens]                                291   1e-78
gi|62241013 AKT1 kinase [Homo sapiens]                                291   1e-78
gi|62241011 AKT1 kinase [Homo sapiens]                                291   1e-78
gi|40254851 protein kinase PKNbeta [Homo sapiens]                     283   5e-76
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   270   3e-72
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   270   3e-72
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   270   3e-72
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   270   3e-72
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   264   2e-70
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   264   2e-70
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph...   264   2e-70

>gi|5453976 protein kinase C, theta [Homo sapiens]
          Length = 706

 Score = 1480 bits (3832), Expect = 0.0
 Identities = 706/706 (100%), Positives = 706/706 (100%)

Query: 1   MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF 60
           MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF
Sbjct: 1   MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF 60

Query: 61  DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR 120
           DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR
Sbjct: 61  DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR 120

Query: 121 YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV 180
           YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV
Sbjct: 121 YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV 180

Query: 181 WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK 240
           WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK
Sbjct: 181 WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK 240

Query: 241 SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ 300
           SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ
Sbjct: 241 SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ 300

Query: 301 ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP 360
           ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP
Sbjct: 301 ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP 360

Query: 361 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 420
           EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD
Sbjct: 361 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 420

Query: 421 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 480
           DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR
Sbjct: 421 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 480

Query: 481 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC 540
           ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC
Sbjct: 481 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC 540

Query: 541 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR 600
           GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR
Sbjct: 541 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR 600

Query: 601 WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD 660
           WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD
Sbjct: 601 WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD 660

Query: 661 CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS 706
           CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS
Sbjct: 661 CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS 706


>gi|47157325 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score =  907 bits (2344), Expect = 0.0
 Identities = 443/705 (62%), Positives = 537/705 (76%), Gaps = 31/705 (4%)

Query: 1   MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF 60
           M+PFLRI  ++++ GS Q+ + EA  P+CAV +KE + +E G+  +QKKPTMYP W STF
Sbjct: 1   MAPFLRIAFNSYELGSLQA-EDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTF 59

Query: 61  DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR 120
           DAHI +GRV+QI++     + +SE TV +  LAERC+KNNGK E WL+L+PQ ++LM+ +
Sbjct: 60  DAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQ 119

Query: 121 YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV 180
           YFLE  D K     E E  F    RRGAIKQAK+H++K HEF ATFF QPTFCSVC +FV
Sbjct: 120 YFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFV 179

Query: 181 WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK 240
           WGLNKQGY+CRQCNAAIHKKCIDK+I +CTG+A NSR+T+F KERF IDMPHRFKV+NY 
Sbjct: 180 WGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYM 239

Query: 241 SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ 300
           SPTFC+HCG+LLWGL +QGLKC+ CGMNVHH+C+ KVANLCGINQKL+AEAL  +  TQ+
Sbjct: 240 SPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQV--TQR 297

Query: 301 ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP 360
           A    D+       PV I                  G  +  G++ E   D       + 
Sbjct: 298 ASRRSDSAS---SEPVGI----------------YQGFEKKTGVAGEDMQDNSGTYGKIW 338

Query: 361 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 420
           E            K  I +FI HK+LGKGSFGKV L E K   ++FAIKALKKDVVL+DD
Sbjct: 339 EGSS---------KCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDD 389

Query: 421 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 480
           DVECTMVEKRVL+LA E+PFLTH+ CTFQTK++LFFVME+LNGGDLMYHIQ   +F+L R
Sbjct: 390 DVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYR 449

Query: 481 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC 540
           ATFYAAEI+ GLQFLHSKGI+YRDLKLDN+LLD+DGHIKIADFGMCKEN+ G+++ +TFC
Sbjct: 450 ATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFC 509

Query: 541 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR 600
           GTPDYIAPEIL G KY  SVDWWSFGVLLYEMLIGQSPFHG DE+ELF SIR+D P YPR
Sbjct: 510 GTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPR 569

Query: 601 WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD 660
           W+ KE+KD+L KLF REP KRLGV G+I+ HP F+ INW  LE++ ++PPFRPKVKSP D
Sbjct: 570 WITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRD 629

Query: 661 CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLI 705
            SNFD+EFLNEK RLS++D+ LI+SMDQ+ F  FSF+NP  E L+
Sbjct: 630 YSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLL 674


>gi|31377782 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score =  907 bits (2344), Expect = 0.0
 Identities = 443/705 (62%), Positives = 537/705 (76%), Gaps = 31/705 (4%)

Query: 1   MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF 60
           M+PFLRI  ++++ GS Q+ + EA  P+CAV +KE + +E G+  +QKKPTMYP W STF
Sbjct: 1   MAPFLRIAFNSYELGSLQA-EDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTF 59

Query: 61  DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR 120
           DAHI +GRV+QI++     + +SE TV +  LAERC+KNNGK E WL+L+PQ ++LM+ +
Sbjct: 60  DAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQ 119

Query: 121 YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV 180
           YFLE  D K     E E  F    RRGAIKQAK+H++K HEF ATFF QPTFCSVC +FV
Sbjct: 120 YFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFV 179

Query: 181 WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK 240
           WGLNKQGY+CRQCNAAIHKKCIDK+I +CTG+A NSR+T+F KERF IDMPHRFKV+NY 
Sbjct: 180 WGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYM 239

Query: 241 SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ 300
           SPTFC+HCG+LLWGL +QGLKC+ CGMNVHH+C+ KVANLCGINQKL+AEAL  +  TQ+
Sbjct: 240 SPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQV--TQR 297

Query: 301 ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP 360
           A    D+       PV I                  G  +  G++ E   D       + 
Sbjct: 298 ASRRSDSAS---SEPVGI----------------YQGFEKKTGVAGEDMQDNSGTYGKIW 338

Query: 361 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 420
           E            K  I +FI HK+LGKGSFGKV L E K   ++FAIKALKKDVVL+DD
Sbjct: 339 EGSS---------KCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDD 389

Query: 421 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 480
           DVECTMVEKRVL+LA E+PFLTH+ CTFQTK++LFFVME+LNGGDLMYHIQ   +F+L R
Sbjct: 390 DVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYR 449

Query: 481 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC 540
           ATFYAAEI+ GLQFLHSKGI+YRDLKLDN+LLD+DGHIKIADFGMCKEN+ G+++ +TFC
Sbjct: 450 ATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFC 509

Query: 541 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR 600
           GTPDYIAPEIL G KY  SVDWWSFGVLLYEMLIGQSPFHG DE+ELF SIR+D P YPR
Sbjct: 510 GTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPR 569

Query: 601 WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD 660
           W+ KE+KD+L KLF REP KRLGV G+I+ HP F+ INW  LE++ ++PPFRPKVKSP D
Sbjct: 570 WITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRD 629

Query: 661 CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLI 705
            SNFD+EFLNEK RLS++D+ LI+SMDQ+ F  FSF+NP  E L+
Sbjct: 630 YSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLL 674


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score =  560 bits (1444), Expect = e-159
 Identities = 297/706 (42%), Positives = 427/706 (60%), Gaps = 47/706 (6%)

Query: 25  VNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNV----D 80
           ++PY A+ V +   S  GQ   ++K T  P W   F   +  GR +++ V         D
Sbjct: 38  LDPYIALNVDD---SRIGQTATKQK-TNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDD 93

Query: 81  LISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDT-----KDMNEFE 135
            ++  T++   L +   ++    E W++L+P+GR+ +     +++S +     KD  E  
Sbjct: 94  FVANCTIQFEELLQNGSRH---FEDWIDLEPEGRVYV----IIDLSGSSGEAPKDNEERV 146

Query: 136 TEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWG-LNKQGYQCRQCN 194
                   +R+GA+++ +VH V  H+F AT+  QPT+CS C +F+WG + KQGYQC+ C 
Sbjct: 147 FRERMRPRKRQGAVRR-RVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCT 205

Query: 195 AAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWG 254
             +HK+C + +I KC G            +RF ++MPH+F ++NYK PTFC+HCG+LLWG
Sbjct: 206 CVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWG 265

Query: 255 LARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREG 314
           L RQGL+C  C MNVH RC+T VA  CG++ + +A+ LA +  T          +     
Sbjct: 266 LLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIA 325

Query: 315 PVEIGLPCSIKN---EARPPCLPT-PGKRE--------PQGISWESPLDEVDKMCHLPEP 362
             E   P S  +   E R    PT P  +E         + +S+++  +E  +    P+ 
Sbjct: 326 GAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEE-HRAASSPDG 384

Query: 363 EL------NKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVV 416
           +L       + R     +L +++F   K+LGKGSFGKV LAE K  ++ +A+K LKKDV+
Sbjct: 385 QLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVI 444

Query: 417 LMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKF 476
           L DDDV+CTM EKR+L+LA +HP+LT ++C FQTK+ LFFVMEY+NGGDLM+ IQ   KF
Sbjct: 445 LQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKF 504

Query: 477 DLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKT 536
           D  R+ FYAAE+   L FLH  G++YRDLKLDNILLD +GH K+ADFGMCKE +L    T
Sbjct: 505 DEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTT 564

Query: 537 NTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNP 596
            TFCGTPDYIAPEIL   +Y  SVDWW+ GVL+YEM+ GQ PF   +E++LF SI  D+ 
Sbjct: 565 TTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDV 624

Query: 597 FYPRWLEKEAKDLLVKLFVREPEKRLGV------RGDIRQHPLFREINWEELERKEIDPP 650
            YP WL KEA  +L     + P KRLG          I+QHP F+EI+W  LE+K+I PP
Sbjct: 625 LYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPP 684

Query: 651 FRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSF 696
           F+P++K+  D +NFD++F  E+P L+  D A++  ++Q  F+ FS+
Sbjct: 685 FKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSY 730


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  541 bits (1394), Expect = e-154
 Identities = 285/694 (41%), Positives = 413/694 (59%), Gaps = 64/694 (9%)

Query: 23  EAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNV--- 79
           + ++PY  V V +    +       K+ T  P ++  F A++  G  +++ V  +     
Sbjct: 39  QLLDPYLTVSVDQVRVGQTST----KQKTNKPTYNEEFCANVTDGGHLELAVFHETPLGY 94

Query: 80  -DLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETEG 138
              ++  T++   L  R    +   E W++L+P+G++      F+ ++ T    E   + 
Sbjct: 95  DHFVANCTLQFQELL-RTTGASDTFEGWVDLEPEGKV------FVVITLTGSFTEATLQR 147

Query: 139 ---FFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGL-NKQGYQCRQCN 194
              F    ++R    + +VH +  H+F AT+  QPT+CS C EF+WG+  KQGYQC+ C 
Sbjct: 148 DRIFKHFTRKRQRAMRRRVHQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCT 207

Query: 195 AAIHKKCIDKVIAKCT-GSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLW 253
             +HK+C   ++  CT  + IN  ++   ++RF I++PH+F ++NYK PTFC+HCG+LLW
Sbjct: 208 CVVHKRCHHLIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLW 267

Query: 254 GLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTEQIFRE 313
           G+ RQGL+C  C MNVH RCQ  VA  CG+N   +A+ LA +   Q       ++ + R 
Sbjct: 268 GIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKTLAGM-GLQPGNISPTSKLVSRS 326

Query: 314 GPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLPEPELNKERPSLQI 373
                    +++ + +         +E  GI   S                         
Sbjct: 327 ---------TLRRQGKE------SSKEGNGIGVNS-----------------------SN 348

Query: 374 KLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 433
           +L I++F   ++LGKGSFGKV LA  K+T   +A+K LKKDV+L DDDVECTM EKR+LS
Sbjct: 349 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 408

Query: 434 LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 493
           LA  HPFLT +FC FQT + LFFVME++NGGDLM+HIQ   +FD +RA FYAAEII  L 
Sbjct: 409 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALM 468

Query: 494 FLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLG 553
           FLH KGI+YRDLKLDN+LLD +GH K+ADFGMCKE +     T TFCGTPDYIAPEIL  
Sbjct: 469 FLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE 528

Query: 554 QKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKL 613
             Y  +VDWW+ GVLLYEML G +PF  ++E++LF +I  D   YP WL ++A  +L   
Sbjct: 529 MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSF 588

Query: 614 FVREPEKRLG--VRGD---IRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEF 668
             + P  RLG   +G    I +HP F+EI+W +L  ++I+PPFRP++KS  D SNFD +F
Sbjct: 589 MTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDF 648

Query: 669 LNEKPRLSFADRALINSMDQNMFRNFSFMNPGME 702
           + E+P L+  D   +  ++Q+ FRNFS+++P ++
Sbjct: 649 IKEEPVLTPIDEGHLPMINQDEFRNFSYVSPELQ 682


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score =  395 bits (1016), Expect = e-110
 Identities = 193/330 (58%), Positives = 238/330 (72%), Gaps = 4/330 (1%)

Query: 374 KLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 433
           ++K+ DF    +LGKGSFGKV L+E K T++ +A+K LKKDVV+ DDDVECTMVEKRVL+
Sbjct: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395

Query: 434 LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 493
           L  + PFLT +   FQT + L+FVMEY+NGGDLMYHIQ   +F    A FYAAEI +GL 
Sbjct: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455

Query: 494 FLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLG 553
           FL SKGI+YRDLKLDN++LD +GHIKIADFGMCKEN+     T TFCGTPDYIAPEI+  
Sbjct: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515

Query: 554 QKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKL 613
           Q Y  SVDWW+FGVLLYEML GQ+PF G+DE+ELF SI   N  YP+ + KEA  +   L
Sbjct: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575

Query: 614 FVREPEKRLGV----RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFL 669
             + P KRLG       DI++H  FR I+WE+LERKEI PP++PK +   D SNFDKEF 
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFT 635

Query: 670 NEKPRLSFADRALINSMDQNMFRNFSFMNP 699
            +   L+  D+  I ++DQN F  FS+ NP
Sbjct: 636 RQPVELTPTDKLFIMNLDQNEFAGFSYTNP 665



 Score =  157 bits (396), Expect = 4e-38
 Identities = 70/138 (50%), Positives = 91/138 (65%), Gaps = 7/138 (5%)

Query: 145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDK 204
           R+GA++Q  VH VK H+FTA FF QPTFCS C +F+WG  KQG+QC+ C   +HK+C + 
Sbjct: 22  RKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81

Query: 205 VIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDA 264
           V   C G+    +       R K    H+FK++ Y SPTFC+HCG+LL+GL  QG+KCD 
Sbjct: 82  VTFSCPGA---DKGPASDDPRSK----HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDT 134

Query: 265 CGMNVHHRCQTKVANLCG 282
           C MNVH RC   V +LCG
Sbjct: 135 CMMNVHKRCVMNVPSLCG 152


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score =  387 bits (995), Expect = e-107
 Identities = 194/343 (56%), Positives = 245/343 (71%), Gaps = 6/343 (1%)

Query: 362 PELNKERPSLQI-KLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 420
           P  ++++PS  + ++K+ DF    +LGKGSFGKV LA+ K T + +AIK LKKDVV+ DD
Sbjct: 320 PSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDD 379

Query: 421 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 480
           DVECTMVEKRVL+L  + PFLT +   FQT + L+FVMEY+NGGDLMYHIQ   KF   +
Sbjct: 380 DVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQ 439

Query: 481 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC 540
           A FYAAEI +GL FLH +GI+YRDLKLDN++LD +GHIKIADFGMCKE+M+    T TFC
Sbjct: 440 AVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFC 499

Query: 541 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR 600
           GTPDYIAPEI+  Q Y  SVDWW++GVLLYEML GQ PF G+DE+ELF SI   N  YP+
Sbjct: 500 GTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPK 559

Query: 601 WLEKEAKDLLVKLFVREPEKRLGV----RGDIRQHPLFREINWEELERKEIDPPFRPKVK 656
            L KEA  +   L  + P KRLG       D+R+H  FR I+WE+LE +EI PPF+PKV 
Sbjct: 560 SLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVC 619

Query: 657 SPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNP 699
                 NFDK F   +P L+  D+ +I ++DQ+ F  FS++NP
Sbjct: 620 GK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP 661



 Score =  154 bits (388), Expect = 4e-37
 Identities = 68/140 (48%), Positives = 93/140 (66%), Gaps = 7/140 (5%)

Query: 145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDK 204
           R+GA++Q  VH VK H+F A FF QPTFCS C +F+WG  KQG+QC+ C   +HK+C + 
Sbjct: 22  RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81

Query: 205 VIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDA 264
           V   C G A    +T   + +      H+FK++ Y SPTFC+HCG+LL+GL  QG+KCD 
Sbjct: 82  VTFSCPG-ADKGPDTDDPRSK------HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDT 134

Query: 265 CGMNVHHRCQTKVANLCGIN 284
           C MNVH +C   V +LCG++
Sbjct: 135 CDMNVHKQCVINVPSLCGMD 154


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score =  382 bits (980), Expect = e-106
 Identities = 189/329 (57%), Positives = 236/329 (71%), Gaps = 5/329 (1%)

Query: 374 KLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 433
           ++K+ DF    +LGKGSFGKV L+E K T++ +A+K LKKDVV+ DDDVECTMVEKRVL+
Sbjct: 336 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 395

Query: 434 LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 493
           L  + PFLT +   FQT + L+FVMEY+NGGDLMYHIQ   +F    A FYAAEI +GL 
Sbjct: 396 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 455

Query: 494 FLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLG 553
           FL SKGI+YRDLKLDN++LD +GHIKIADFGMCKEN+     T TFCGTPDYIAPEI+  
Sbjct: 456 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 515

Query: 554 QKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKL 613
           Q Y  SVDWW+FGVLLYEML GQ+PF G+DE+ELF SI   N  YP+ + KEA  +   L
Sbjct: 516 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGL 575

Query: 614 FVREPEKRLGV----RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFL 669
             + P KRLG       DI++H  FR I+WE+LERKEI PP++PK     +  NFD+ F 
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRFFT 634

Query: 670 NEKPRLSFADRALINSMDQNMFRNFSFMN 698
              P L+  D+ +I ++DQ+ F  FSF+N
Sbjct: 635 RHPPVLTPPDQEVIRNIDQSEFEGFSFVN 663



 Score =  157 bits (396), Expect = 4e-38
 Identities = 70/138 (50%), Positives = 91/138 (65%), Gaps = 7/138 (5%)

Query: 145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDK 204
           R+GA++Q  VH VK H+FTA FF QPTFCS C +F+WG  KQG+QC+ C   +HK+C + 
Sbjct: 22  RKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEF 81

Query: 205 VIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDA 264
           V   C G+    +       R K    H+FK++ Y SPTFC+HCG+LL+GL  QG+KCD 
Sbjct: 82  VTFSCPGA---DKGPASDDPRSK----HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDT 134

Query: 265 CGMNVHHRCQTKVANLCG 282
           C MNVH RC   V +LCG
Sbjct: 135 CMMNVHKRCVMNVPSLCG 152


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score =  363 bits (931), Expect = e-100
 Identities = 187/335 (55%), Positives = 228/335 (68%), Gaps = 10/335 (2%)

Query: 374 KLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 433
           +L I DF    +LGKGSFGKV LAE + +++ +AIK LKKDV++ DDDV+CT+VEKRVL+
Sbjct: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404

Query: 434 LAWEHP-----FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEI 488
           L    P     FLT +  TFQT + L+FVMEY+ GGDLMYHIQ   KF    A FYAAEI
Sbjct: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464

Query: 489 ILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAP 548
            +GL FLH++GI+YRDLKLDN++LD +GHIKI DFGMCKEN+     T TFCGTPDYIAP
Sbjct: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524

Query: 549 EILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKD 608
           EI+  Q Y  SVDWWSFGVLLYEML GQ PF G+DEEELF +I      YP+ L +EA  
Sbjct: 525 EIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVA 584

Query: 609 LLVKLFVREPEKRLGVRGD----IRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNF 664
           +      + P KRLG   D    IR H  FR I+WE LER EI PPFRP+        NF
Sbjct: 585 ICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPR-PCGRSGENF 643

Query: 665 DKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNP 699
           DK F    P L+  DR ++ S+DQ  F+ F+++NP
Sbjct: 644 DKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNP 678



 Score =  155 bits (393), Expect = 9e-38
 Identities = 66/140 (47%), Positives = 96/140 (68%), Gaps = 7/140 (5%)

Query: 145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDK 204
           R+GA++Q  VH VK H+FTA FF QPTFCS C +F+WG+ KQG QC+ C+  +H++C + 
Sbjct: 21  RKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEF 80

Query: 205 VIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDA 264
           V  +C G+     +T   + +      H+F++++Y SPTFC+HCG+LL+GL  QG+KC  
Sbjct: 81  VTFECPGAG-KGPQTDDPRNK------HKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSC 133

Query: 265 CGMNVHHRCQTKVANLCGIN 284
           C MNVH RC   V +LCG++
Sbjct: 134 CEMNVHRRCVRSVPSLCGVD 153


>gi|133908623 protein kinase C, iota [Homo sapiens]
          Length = 596

 Score =  336 bits (862), Expect = 4e-92
 Identities = 177/482 (36%), Positives = 259/482 (53%), Gaps = 49/482 (10%)

Query: 232 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEA 291
           H F+   +     C  C   +WGL RQG KC  C + VH +C   V   CG +       
Sbjct: 141 HTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPQEPV 200

Query: 292 LAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLD 351
           + M +S+  +                        + A+      P   E           
Sbjct: 201 MPMDQSSMHS------------------------DHAQTVIPYNPSSHE----------- 225

Query: 352 EVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKAL 411
            +D++    E    +E       L ++DF L +++G+GS+ KV L   KKT++ +A+K +
Sbjct: 226 SLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVV 285

Query: 412 KKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQ 471
           KK++V  D+D++    EK V   A  HPFL  +   FQT+  LFFV+EY+NGGDLM+H+Q
Sbjct: 286 KKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQ 345

Query: 472 SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENML 531
              K     A FY+AEI L L +LH +GI+YRDLKLDN+LLD +GHIK+ D+GMCKE + 
Sbjct: 346 RQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLR 405

Query: 532 GDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPF---------HGQ 582
               T+TFCGTP+YIAPEIL G+ Y  SVDWW+ GVL++EM+ G+SPF            
Sbjct: 406 PGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQN 465

Query: 583 DEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVR-----GDIRQHPLFREI 637
            E+ LF  I       PR L  +A  +L     ++P++RLG        DI+ HP FR +
Sbjct: 466 TEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNV 525

Query: 638 NWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFM 697
           +W+ +E+K++ PPF+P +   F   NFD +F NE  +L+  D  ++  +DQ+ F  F ++
Sbjct: 526 DWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYI 585

Query: 698 NP 699
           NP
Sbjct: 586 NP 587



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 25/65 (38%), Positives = 37/65 (56%)

Query: 145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDK 204
           RRGA +  K++    H F A  F +   C++C + +WGL +QGY+C  C   +HKKC   
Sbjct: 126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKL 185

Query: 205 VIAKC 209
           V  +C
Sbjct: 186 VTIEC 190


>gi|5453974 protein kinase N2 [Homo sapiens]
          Length = 984

 Score =  332 bits (851), Expect = 7e-91
 Identities = 168/342 (49%), Positives = 228/342 (66%), Gaps = 8/342 (2%)

Query: 363 ELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDV 422
           EL   R   + +  ++DF    +LG+G FGKV LAE+K TN+ FAIKALKK  ++  D+V
Sbjct: 640 ELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEV 699

Query: 423 ECTMVEKRVLSL--AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 480
           +  M EKR+     +  HPFL ++F  FQTKE++ FVMEY  GGDLM HI +   F   R
Sbjct: 700 DSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPR 758

Query: 481 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC 540
           A FYAA ++LGLQ+LH   IVYRDLKLDN+LLD +G +KIADFG+CKE M    +T+TFC
Sbjct: 759 AVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFC 818

Query: 541 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR 600
           GTP+++APE+L    Y  +VDWW  GVL+YEML+G+SPF G DEEE+F SI  D   YPR
Sbjct: 819 GTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPR 878

Query: 601 WLEKEAKDLLVKLFVREPEKRLGV----RGDIRQHPLFREINWEELERKEIDPPFRPKVK 656
           +L  EA  ++ +L  R PE+RLG       D+++HP FR I+W  L  K++ PPF P ++
Sbjct: 879 FLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIR 938

Query: 657 SPFDCSNFDKEFLNEKPRLS-FADRALINSMDQNMFRNFSFM 697
              D SNFD EF +E P L+   +  +++  +Q MFR+F ++
Sbjct: 939 GREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYI 980


>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
          Length = 592

 Score =  330 bits (846), Expect = 3e-90
 Identities = 185/484 (38%), Positives = 270/484 (55%), Gaps = 47/484 (9%)

Query: 232 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEA 291
           H F+   +    +C  C   +WGLARQG +C  C + VH RC   V   C          
Sbjct: 131 HLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC---------- 180

Query: 292 LAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLD 351
                     R   D+    +E PV+       KNE     LP+    E  GI++ S   
Sbjct: 181 ----------RKHMDSVMPSQEPPVDD------KNEDAD--LPS---EETDGIAYISSSR 219

Query: 352 EVDKMCHLPE---PELN-KERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFA 407
           + D +    E   P ++  +   +   L ++DF L +++G+GS+ KV L   KK +Q +A
Sbjct: 220 KHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYA 279

Query: 408 IKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLM 467
           +K +KK++V  D+D++    EK V   A  +PFL  +   FQT   LF V+EY+NGGDLM
Sbjct: 280 MKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLM 339

Query: 468 YHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCK 527
           +H+Q   K     A FYAAEI + L FLH +GI+YRDLKLDN+LLD DGHIK+ D+GMCK
Sbjct: 340 FHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCK 399

Query: 528 ENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFH------G 581
           E +     T+TFCGTP+YIAPEIL G++Y  SVDWW+ GVL++EM+ G+SPF        
Sbjct: 400 EGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPD 459

Query: 582 QDEEELFHSIRMDNPF-YPRWLEKEAKDLLVKLFVREPEKRLGVR-----GDIRQHPLFR 635
            + E+    + ++ P   PR+L  +A  +L     ++P++RLG R      DI+ H  FR
Sbjct: 460 MNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFR 519

Query: 636 EINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFS 695
            I+W+ LE+K+  PPF+P++   +   NFD +F +E  +L+  D   I  +DQ+ F  F 
Sbjct: 520 SIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFE 579

Query: 696 FMNP 699
           ++NP
Sbjct: 580 YINP 583



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 30/90 (33%), Positives = 44/90 (48%), Gaps = 3/90 (3%)

Query: 145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDK 204
           RRGA +  K++    H F A  F +  +C  C E +WGL +QGY+C  C   +HK+C   
Sbjct: 116 RRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGL 175

Query: 205 VIAKC---TGSAINSRETMFHKERFKIDMP 231
           V   C     S + S+E     +    D+P
Sbjct: 176 VPLTCRKHMDSVMPSQEPPVDDKNEDADLP 205


>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
          Length = 948

 Score =  321 bits (823), Expect = 1e-87
 Identities = 178/381 (46%), Positives = 234/381 (61%), Gaps = 16/381 (4%)

Query: 334 PTPGKREPQGI--SWESPLDEVDKMCHLPEPELNKERPSL-----QIKLKIEDFILHKML 386
           P    R+P     S  SP+ E      LP        P+L     +  L +EDF    +L
Sbjct: 569 PQKSSRDPPSSPSSLSSPIQE-STAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVL 627

Query: 387 GKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWE--HPFLTHM 444
           G+G FGKV L+EF+ + + FAIKALKK  ++  D+VE  M EKR+L+      HPFL ++
Sbjct: 628 GRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNL 687

Query: 445 FCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRD 504
           F  FQT E++ FVMEY  GGDLM HI S   F   RA FY+A ++LGLQFLH   IVYRD
Sbjct: 688 FGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFLHEHKIVYRD 746

Query: 505 LKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWS 564
           LKLDN+LLD +G++KIADFG+CKE M    +T+TFCGTP+++APE+L    Y  +VDWW 
Sbjct: 747 LKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWG 806

Query: 565 FGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGV 624
            GVLLYEML+G+SPF G DEEE+F SI  D   YPR+L  EA  ++ +L  R PE+RLG 
Sbjct: 807 LGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGS 866

Query: 625 ----RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLS-FAD 679
                 D+++ P FR + WE L  + + PPF P +    D SNFD+EF  E P LS   D
Sbjct: 867 SERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRD 926

Query: 680 RALINSMDQNMFRNFSFMNPG 700
              + + +Q  F +F F+  G
Sbjct: 927 ARPLTAAEQAAFLDFDFVAGG 947


>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
          Length = 942

 Score =  321 bits (823), Expect = 1e-87
 Identities = 178/381 (46%), Positives = 234/381 (61%), Gaps = 16/381 (4%)

Query: 334 PTPGKREPQGI--SWESPLDEVDKMCHLPEPELNKERPSL-----QIKLKIEDFILHKML 386
           P    R+P     S  SP+ E      LP        P+L     +  L +EDF    +L
Sbjct: 563 PQKSSRDPPSSPSSLSSPIQE-STAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVL 621

Query: 387 GKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWE--HPFLTHM 444
           G+G FGKV L+EF+ + + FAIKALKK  ++  D+VE  M EKR+L+      HPFL ++
Sbjct: 622 GRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNL 681

Query: 445 FCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRD 504
           F  FQT E++ FVMEY  GGDLM HI S   F   RA FY+A ++LGLQFLH   IVYRD
Sbjct: 682 FGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFLHEHKIVYRD 740

Query: 505 LKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWS 564
           LKLDN+LLD +G++KIADFG+CKE M    +T+TFCGTP+++APE+L    Y  +VDWW 
Sbjct: 741 LKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWG 800

Query: 565 FGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGV 624
            GVLLYEML+G+SPF G DEEE+F SI  D   YPR+L  EA  ++ +L  R PE+RLG 
Sbjct: 801 LGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGS 860

Query: 625 ----RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLS-FAD 679
                 D+++ P FR + WE L  + + PPF P +    D SNFD+EF  E P LS   D
Sbjct: 861 SERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRD 920

Query: 680 RALINSMDQNMFRNFSFMNPG 700
              + + +Q  F +F F+  G
Sbjct: 921 ARPLTAAEQAAFLDFDFVAGG 941


>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  307 bits (786), Expect = 2e-83
 Identities = 149/337 (44%), Positives = 216/337 (64%), Gaps = 12/337 (3%)

Query: 375 LKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSL 434
           L ++DF L +++G+GS+ KV L   KK +Q +A+K +KK++V  D+D++    EK V   
Sbjct: 64  LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123

Query: 435 AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQF 494
           A  +PFL  +   FQT   LF V+EY+NGGDLM+H+Q   K     A FYAAEI + L F
Sbjct: 124 ASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNF 183

Query: 495 LHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQ 554
           LH +GI+YRDLKLDN+LLD DGHIK+ D+GMCKE +     T+TFCGTP+YIAPEIL G+
Sbjct: 184 LHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE 243

Query: 555 KYNHSVDWWSFGVLLYEMLIGQSPFH------GQDEEELFHSIRMDNPF-YPRWLEKEAK 607
           +Y  SVDWW+ GVL++EM+ G+SPF         + E+    + ++ P   PR+L  +A 
Sbjct: 244 EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303

Query: 608 DLLVKLFVREPEKRLGVR-----GDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCS 662
            +L     ++P++RLG R      DI+ H  FR I+W+ LE+K+  PPF+P++   +   
Sbjct: 304 HVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLD 363

Query: 663 NFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNP 699
           NFD +F +E  +L+  D   I  +DQ+ F  F ++NP
Sbjct: 364 NFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400


>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  307 bits (786), Expect = 2e-83
 Identities = 149/337 (44%), Positives = 216/337 (64%), Gaps = 12/337 (3%)

Query: 375 LKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSL 434
           L ++DF L +++G+GS+ KV L   KK +Q +A+K +KK++V  D+D++    EK V   
Sbjct: 64  LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123

Query: 435 AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQF 494
           A  +PFL  +   FQT   LF V+EY+NGGDLM+H+Q   K     A FYAAEI + L F
Sbjct: 124 ASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNF 183

Query: 495 LHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQ 554
           LH +GI+YRDLKLDN+LLD DGHIK+ D+GMCKE +     T+TFCGTP+YIAPEIL G+
Sbjct: 184 LHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE 243

Query: 555 KYNHSVDWWSFGVLLYEMLIGQSPFH------GQDEEELFHSIRMDNPF-YPRWLEKEAK 607
           +Y  SVDWW+ GVL++EM+ G+SPF         + E+    + ++ P   PR+L  +A 
Sbjct: 244 EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303

Query: 608 DLLVKLFVREPEKRLGVR-----GDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCS 662
            +L     ++P++RLG R      DI+ H  FR I+W+ LE+K+  PPF+P++   +   
Sbjct: 304 HVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLD 363

Query: 663 NFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNP 699
           NFD +F +E  +L+  D   I  +DQ+ F  F ++NP
Sbjct: 364 NFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  300 bits (768), Expect = 3e-81
 Identities = 153/359 (42%), Positives = 218/359 (60%), Gaps = 14/359 (3%)

Query: 351 DEVDKMCHLPEPELNKERPSLQI-----KLKIEDFILHKMLGKGSFGKVFLAEFKKTNQF 405
           D +D  C  P      E   + +     K+ + DF   K+LGKG+FGKV L   K T ++
Sbjct: 118 DPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRY 177

Query: 406 FAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGD 465
           +A+K L+K+V++  D+V  T+ E RVL     HPFLT +   FQT + L FVMEY NGG+
Sbjct: 178 YAMKILRKEVIIAKDEVAHTVTESRVLQNT-RHPFLTALKYAFQTHDRLCFVMEYANGGE 236

Query: 466 LMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGM 525
           L +H+     F   RA FY AEI+  L++LHS+ +VYRD+KL+N++LDKDGHIKI DFG+
Sbjct: 237 LFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGL 296

Query: 526 CKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEE 585
           CKE +   A   TFCGTP+Y+APE+L    Y  +VDWW  GV++YEM+ G+ PF+ QD E
Sbjct: 297 CKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 356

Query: 586 ELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLG----VRGDIRQHPLFREINWEE 641
            LF  I M+   +PR L  EAK LL  L  ++P++RLG       ++ +H  F  INW++
Sbjct: 357 RLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQD 416

Query: 642 LERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADR----ALINSMDQNMFRNFSF 696
           + +K++ PPF+P+V S  D   FD EF  +   ++  DR     L+    +  F  FS+
Sbjct: 417 VVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  299 bits (765), Expect = 7e-81
 Identities = 157/365 (43%), Positives = 226/365 (61%), Gaps = 15/365 (4%)

Query: 348 SPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFA 407
           SP  ++D   ++ E E++      + K  + DF   K+LGKG+FGKV L   K + +++A
Sbjct: 120 SPTSQID---NIGEEEMDASTTHHKRKT-MNDFDYLKLLGKGTFGKVILVREKASGKYYA 175

Query: 408 IKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLM 467
           +K LKK+V++  D+V  T+ E RVL     HPFLT +  +FQTK+ L FVMEY+NGG+L 
Sbjct: 176 MKILKKEVIIAKDEVAHTLTESRVLKNT-RHPFLTSLKYSFQTKDRLCFVMEYVNGGELF 234

Query: 468 YHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCK 527
           +H+     F   R  FY AEI+  L +LHS  IVYRDLKL+N++LDKDGHIKI DFG+CK
Sbjct: 235 FHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK 294

Query: 528 ENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEEL 587
           E +   A   TFCGTP+Y+APE+L    Y  +VDWW  GV++YEM+ G+ PF+ QD E+L
Sbjct: 295 EGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354

Query: 588 FHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGD----IRQHPLFREINWEELE 643
           F  I M++  +PR L  +AK LL  L +++P KRLG   D    I +H  F  +NW+++ 
Sbjct: 355 FELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVY 414

Query: 644 RKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMD------QNMFRNFSFM 697
            K++ PPF+P+V S  D   FD+EF  +   ++  ++   + MD      +  F  FS+ 
Sbjct: 415 DKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYS 474

Query: 698 NPGME 702
             G E
Sbjct: 475 ASGRE 479


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  298 bits (763), Expect = 1e-80
 Identities = 150/325 (46%), Positives = 211/325 (64%), Gaps = 9/325 (2%)

Query: 348 SPLDEVDKMCHLPEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFA 407
           SP  ++D   ++ E E++      + K  + DF   K+LGKG+FGKV L   K + +++A
Sbjct: 120 SPTSQID---NIGEEEMDASTTHHKRKT-MNDFDYLKLLGKGTFGKVILVREKASGKYYA 175

Query: 408 IKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLM 467
           +K LKK+V++  D+V  T+ E RVL     HPFLT +  +FQTK+ L FVMEY+NGG+L 
Sbjct: 176 MKILKKEVIIAKDEVAHTLTESRVLKNT-RHPFLTSLKYSFQTKDRLCFVMEYVNGGELF 234

Query: 468 YHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCK 527
           +H+     F   R  FY AEI+  L +LHS  IVYRDLKL+N++LDKDGHIKI DFG+CK
Sbjct: 235 FHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK 294

Query: 528 ENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEEL 587
           E +   A   TFCGTP+Y+APE+L    Y  +VDWW  GV++YEM+ G+ PF+ QD E+L
Sbjct: 295 EGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKL 354

Query: 588 FHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGD----IRQHPLFREINWEELE 643
           F  I M++  +PR L  +AK LL  L +++P KRLG   D    I +H  F  +NW+++ 
Sbjct: 355 FELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVY 414

Query: 644 RKEIDPPFRPKVKSPFDCSNFDKEF 668
            K++ PPF+P+V S  D   FD+EF
Sbjct: 415 DKKLVPPFKPQVTSETDTRYFDEEF 439


>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  291 bits (745), Expect = 1e-78
 Identities = 152/349 (43%), Positives = 220/349 (63%), Gaps = 12/349 (3%)

Query: 361 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 420
           E E++  +P  ++ +   +++  K+LGKG+FGKV L + K T +++A+K LKK+V++  D
Sbjct: 133 EMEVSLAKPKHRVTMNEFEYL--KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKD 190

Query: 421 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 480
           +V  T+ E RVL  +  HPFLT +  +FQT + L FVMEY NGG+L +H+     F   R
Sbjct: 191 EVAHTLTENRVLQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDR 249

Query: 481 ATFYAAEIILGLQFLHS-KGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTF 539
           A FY AEI+  L +LHS K +VYRDLKL+N++LDKDGHIKI DFG+CKE +   A   TF
Sbjct: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF 309

Query: 540 CGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYP 599
           CGTP+Y+APE+L    Y  +VDWW  GV++YEM+ G+ PF+ QD E+LF  I M+   +P
Sbjct: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP 369

Query: 600 RWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRPKV 655
           R L  EAK LL  L  ++P++RLG       +I QH  F  I W+ +  K++ PPF+P+V
Sbjct: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQV 429

Query: 656 KSPFDCSNFDKEFLNEKPRLSFADR----ALINSMDQNMFRNFSFMNPG 700
            S  D   FD+EF  +   ++  D+      ++S  +  F  FS+   G
Sbjct: 430 TSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASG 478


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  291 bits (745), Expect = 1e-78
 Identities = 152/349 (43%), Positives = 220/349 (63%), Gaps = 12/349 (3%)

Query: 361 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 420
           E E++  +P  ++ +   +++  K+LGKG+FGKV L + K T +++A+K LKK+V++  D
Sbjct: 133 EMEVSLAKPKHRVTMNEFEYL--KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKD 190

Query: 421 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 480
           +V  T+ E RVL  +  HPFLT +  +FQT + L FVMEY NGG+L +H+     F   R
Sbjct: 191 EVAHTLTENRVLQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDR 249

Query: 481 ATFYAAEIILGLQFLHS-KGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTF 539
           A FY AEI+  L +LHS K +VYRDLKL+N++LDKDGHIKI DFG+CKE +   A   TF
Sbjct: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF 309

Query: 540 CGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYP 599
           CGTP+Y+APE+L    Y  +VDWW  GV++YEM+ G+ PF+ QD E+LF  I M+   +P
Sbjct: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP 369

Query: 600 RWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRPKV 655
           R L  EAK LL  L  ++P++RLG       +I QH  F  I W+ +  K++ PPF+P+V
Sbjct: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQV 429

Query: 656 KSPFDCSNFDKEFLNEKPRLSFADR----ALINSMDQNMFRNFSFMNPG 700
            S  D   FD+EF  +   ++  D+      ++S  +  F  FS+   G
Sbjct: 430 TSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASG 478


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  291 bits (745), Expect = 1e-78
 Identities = 152/349 (43%), Positives = 220/349 (63%), Gaps = 12/349 (3%)

Query: 361 EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD 420
           E E++  +P  ++ +   +++  K+LGKG+FGKV L + K T +++A+K LKK+V++  D
Sbjct: 133 EMEVSLAKPKHRVTMNEFEYL--KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKD 190

Query: 421 DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 480
           +V  T+ E RVL  +  HPFLT +  +FQT + L FVMEY NGG+L +H+     F   R
Sbjct: 191 EVAHTLTENRVLQNS-RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDR 249

Query: 481 ATFYAAEIILGLQFLHS-KGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTF 539
           A FY AEI+  L +LHS K +VYRDLKL+N++LDKDGHIKI DFG+CKE +   A   TF
Sbjct: 250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF 309

Query: 540 CGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYP 599
           CGTP+Y+APE+L    Y  +VDWW  GV++YEM+ G+ PF+ QD E+LF  I M+   +P
Sbjct: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP 369

Query: 600 RWLEKEAKDLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRPKV 655
           R L  EAK LL  L  ++P++RLG       +I QH  F  I W+ +  K++ PPF+P+V
Sbjct: 370 RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQV 429

Query: 656 KSPFDCSNFDKEFLNEKPRLSFADR----ALINSMDQNMFRNFSFMNPG 700
            S  D   FD+EF  +   ++  D+      ++S  +  F  FS+   G
Sbjct: 430 TSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASG 478


>gi|40254851 protein kinase PKNbeta [Homo sapiens]
          Length = 889

 Score =  283 bits (723), Expect = 5e-76
 Identities = 152/331 (45%), Positives = 205/331 (61%), Gaps = 10/331 (3%)

Query: 376 KIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLA 435
           +++DF    +LG+G FGKV L +FK T +++AIKALKK  VL  D++E    EKR+L   
Sbjct: 555 RLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAV 614

Query: 436 W--EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 493
               HPFL  +   FQT  +  FV E++ GGDLM  I     F   +A FY A ++LGLQ
Sbjct: 615 GCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHE-DVFPEPQARFYVACVVLGLQ 673

Query: 494 FLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLG 553
           FLH K I+YRDLKLDN+LLD  G +KIADFG+CKE +    +T+TFCGTP+++APE+L  
Sbjct: 674 FLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQ 733

Query: 554 QKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI-RMDNPFYPRWLEKEAKDLLVK 612
           + Y  +VDWW  GVLLYEML+G+ PF G  EEE+F  I  MD P YP +L  +  + + K
Sbjct: 734 EAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAP-YPGFLSVQGLEFIQK 792

Query: 613 LFVREPEKRLGV----RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEF 668
           L  + PEKRLG       +I+  P FR  NW+ L  + I PPF P +  P D   F+ EF
Sbjct: 793 LLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEF 852

Query: 669 LNEKPRLS-FADRALINSMDQNMFRNFSFMN 698
               P L+  A  +L+ +  Q  FR+F F++
Sbjct: 853 TGLPPALTPPAPHSLLTARQQAAFRDFDFVS 883


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  270 bits (691), Expect = 3e-72
 Identities = 148/335 (44%), Positives = 201/335 (60%), Gaps = 19/335 (5%)

Query: 355 KMCHLPEPELNKERPS------LQIKL--------KIEDFILHKMLGKGSFGKVFLAEFK 400
           K+    EPEL    PS       QI L        K  DF   K++GKGSFGKV LA  K
Sbjct: 59  KISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHK 118

Query: 401 KTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEY 460
               F+A+K L+K  +L   + +  M E+ VL    +HPFL  +  +FQT + L+FV++Y
Sbjct: 119 AEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDY 178

Query: 461 LNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKI 520
           +NGG+L YH+Q    F   RA FYAAEI   L +LHS  IVYRDLK +NILLD  GHI +
Sbjct: 179 INGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVL 238

Query: 521 ADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFH 580
            DFG+CKEN+  ++ T+TFCGTP+Y+APE+L  Q Y+ +VDWW  G +LYEML G  PF+
Sbjct: 239 TDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFY 298

Query: 581 GQDEEELFHSIRMDNPFYPR-WLEKEAKDLLVKLFVREPEKRLGVRGD---IRQHPLFRE 636
            ++  E++ +I ++ P   +  +   A+ LL  L  ++  KRLG + D   I+ H  F  
Sbjct: 299 SRNTAEMYDNI-LNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSL 357

Query: 637 INWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNE 671
           INW++L  K+I PPF P V  P D  +FD EF  E
Sbjct: 358 INWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 392


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  270 bits (691), Expect = 3e-72
 Identities = 148/335 (44%), Positives = 201/335 (60%), Gaps = 19/335 (5%)

Query: 355 KMCHLPEPELNKERPS------LQIKL--------KIEDFILHKMLGKGSFGKVFLAEFK 400
           K+    EPEL    PS       QI L        K  DF   K++GKGSFGKV LA  K
Sbjct: 73  KISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHK 132

Query: 401 KTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEY 460
               F+A+K L+K  +L   + +  M E+ VL    +HPFL  +  +FQT + L+FV++Y
Sbjct: 133 AEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDY 192

Query: 461 LNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKI 520
           +NGG+L YH+Q    F   RA FYAAEI   L +LHS  IVYRDLK +NILLD  GHI +
Sbjct: 193 INGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVL 252

Query: 521 ADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFH 580
            DFG+CKEN+  ++ T+TFCGTP+Y+APE+L  Q Y+ +VDWW  G +LYEML G  PF+
Sbjct: 253 TDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFY 312

Query: 581 GQDEEELFHSIRMDNPFYPR-WLEKEAKDLLVKLFVREPEKRLGVRGD---IRQHPLFRE 636
            ++  E++ +I ++ P   +  +   A+ LL  L  ++  KRLG + D   I+ H  F  
Sbjct: 313 SRNTAEMYDNI-LNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSL 371

Query: 637 INWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNE 671
           INW++L  K+I PPF P V  P D  +FD EF  E
Sbjct: 372 INWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 406


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  270 bits (691), Expect = 3e-72
 Identities = 148/335 (44%), Positives = 201/335 (60%), Gaps = 19/335 (5%)

Query: 355 KMCHLPEPELNKERPS------LQIKL--------KIEDFILHKMLGKGSFGKVFLAEFK 400
           K+    EPEL    PS       QI L        K  DF   K++GKGSFGKV LA  K
Sbjct: 87  KISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHK 146

Query: 401 KTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEY 460
               F+A+K L+K  +L   + +  M E+ VL    +HPFL  +  +FQT + L+FV++Y
Sbjct: 147 AEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDY 206

Query: 461 LNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKI 520
           +NGG+L YH+Q    F   RA FYAAEI   L +LHS  IVYRDLK +NILLD  GHI +
Sbjct: 207 INGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVL 266

Query: 521 ADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFH 580
            DFG+CKEN+  ++ T+TFCGTP+Y+APE+L  Q Y+ +VDWW  G +LYEML G  PF+
Sbjct: 267 TDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFY 326

Query: 581 GQDEEELFHSIRMDNPFYPR-WLEKEAKDLLVKLFVREPEKRLGVRGD---IRQHPLFRE 636
            ++  E++ +I ++ P   +  +   A+ LL  L  ++  KRLG + D   I+ H  F  
Sbjct: 327 SRNTAEMYDNI-LNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSL 385

Query: 637 INWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNE 671
           INW++L  K+I PPF P V  P D  +FD EF  E
Sbjct: 386 INWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 420


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  270 bits (691), Expect = 3e-72
 Identities = 148/335 (44%), Positives = 201/335 (60%), Gaps = 19/335 (5%)

Query: 355 KMCHLPEPELNKERPS------LQIKL--------KIEDFILHKMLGKGSFGKVFLAEFK 400
           K+    EPEL    PS       QI L        K  DF   K++GKGSFGKV LA  K
Sbjct: 154 KISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHK 213

Query: 401 KTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEY 460
               F+A+K L+K  +L   + +  M E+ VL    +HPFL  +  +FQT + L+FV++Y
Sbjct: 214 AEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDY 273

Query: 461 LNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKI 520
           +NGG+L YH+Q    F   RA FYAAEI   L +LHS  IVYRDLK +NILLD  GHI +
Sbjct: 274 INGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVL 333

Query: 521 ADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFH 580
            DFG+CKEN+  ++ T+TFCGTP+Y+APE+L  Q Y+ +VDWW  G +LYEML G  PF+
Sbjct: 334 TDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFY 393

Query: 581 GQDEEELFHSIRMDNPFYPR-WLEKEAKDLLVKLFVREPEKRLGVRGD---IRQHPLFRE 636
            ++  E++ +I ++ P   +  +   A+ LL  L  ++  KRLG + D   I+ H  F  
Sbjct: 394 SRNTAEMYDNI-LNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSL 452

Query: 637 INWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNE 671
           INW++L  K+I PPF P V  P D  +FD EF  E
Sbjct: 453 INWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 487


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  264 bits (674), Expect = 2e-70
 Identities = 143/341 (41%), Positives = 205/341 (60%), Gaps = 11/341 (3%)

Query: 369 PSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVE 428
           PS     K  DF   K++GKGSFGKV LA+ K   +F+A+K L+K +VL   + +  M E
Sbjct: 151 PSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAE 210

Query: 429 KRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEI 488
           + VL    +HPFL  +  +FQT E L+FV++++NGG+L +H+Q    F   RA FYAAEI
Sbjct: 211 RNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEI 270

Query: 489 ILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAP 548
              L +LHS  IVYRDLK +NILLD  GH+ + DFG+CKE +     T TFCGTP+Y+AP
Sbjct: 271 ASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAP 330

Query: 549 EILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR-WLEKEAK 607
           E++  Q Y+++VDWW  G +LYEML G  PF+ +D  E++ +I +  P   R  +   A 
Sbjct: 331 EVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNI-LHKPLSLRPGVSLTAW 389

Query: 608 DLLVKLFVREPEKRLGVRGD---IRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNF 664
            +L +L  ++ + RLG + D   I+ HP F  ++W +L +K+I PPF P V  P D  NF
Sbjct: 390 SILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNF 449

Query: 665 DKEFLNEKPRLSF---ADRALINSM---DQNMFRNFSFMNP 699
           D  F  E    S    +D +++N+      + F  FS+  P
Sbjct: 450 DTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490


>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  264 bits (674), Expect = 2e-70
 Identities = 143/341 (41%), Positives = 205/341 (60%), Gaps = 11/341 (3%)

Query: 369 PSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVE 428
           PS     K  DF   K++GKGSFGKV LA+ K   +F+A+K L+K +VL   + +  M E
Sbjct: 151 PSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAE 210

Query: 429 KRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEI 488
           + VL    +HPFL  +  +FQT E L+FV++++NGG+L +H+Q    F   RA FYAAEI
Sbjct: 211 RNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEI 270

Query: 489 ILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAP 548
              L +LHS  IVYRDLK +NILLD  GH+ + DFG+CKE +     T TFCGTP+Y+AP
Sbjct: 271 ASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAP 330

Query: 549 EILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR-WLEKEAK 607
           E++  Q Y+++VDWW  G +LYEML G  PF+ +D  E++ +I +  P   R  +   A 
Sbjct: 331 EVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNI-LHKPLSLRPGVSLTAW 389

Query: 608 DLLVKLFVREPEKRLGVRGD---IRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNF 664
            +L +L  ++ + RLG + D   I+ HP F  ++W +L +K+I PPF P V  P D  NF
Sbjct: 390 SILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNF 449

Query: 665 DKEFLNEKPRLSF---ADRALINSM---DQNMFRNFSFMNP 699
           D  F  E    S    +D +++N+      + F  FS+  P
Sbjct: 450 DTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490


>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
           [Homo sapiens]
          Length = 367

 Score =  264 bits (674), Expect = 2e-70
 Identities = 137/334 (41%), Positives = 194/334 (58%), Gaps = 6/334 (1%)

Query: 369 PSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVE 428
           PS     +  DF   K++GKG++GKV LA+ K    F+A+K L+K  +L   +    M E
Sbjct: 24  PSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAE 83

Query: 429 KRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEI 488
           + VL     HPFL  +  +FQT E L+FV++Y+NGG+L +H+Q   +F   RA FYAAE+
Sbjct: 84  RSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEV 143

Query: 489 ILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAP 548
              + +LHS  I+YRDLK +NILLD  GH+ + DFG+CKE +  +  T+TFCGTP+Y+AP
Sbjct: 144 ASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAP 203

Query: 549 EILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKD 608
           E+L  + Y+ +VDWW  G +LYEML G  PF+ QD  +++ +I       P      A D
Sbjct: 204 EVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACD 263

Query: 609 LLVKLFVREPEKRLGVRGD---IRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFD 665
           LL  L  ++  +RLG + D   I+ H  F  INW++L  K + PPF P V  P D  +FD
Sbjct: 264 LLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFD 323

Query: 666 KEFLNEKPRLSFA---DRALINSMDQNMFRNFSF 696
            EF  E    S     D    +S   + F  FS+
Sbjct: 324 PEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,107,655
Number of Sequences: 37866
Number of extensions: 1421794
Number of successful extensions: 6090
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 764
Number of HSP's successfully gapped in prelim test: 107
Number of HSP's that attempted gapping in prelim test: 3321
Number of HSP's gapped (non-prelim): 1243
length of query: 706
length of database: 18,247,518
effective HSP length: 109
effective length of query: 597
effective length of database: 14,120,124
effective search space: 8429714028
effective search space used: 8429714028
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.