Search of human proteins with 5453974

Search of human proteins with 5453974

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5453974 protein kinase N2 [Homo sapiens]
         (984 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5453974 protein kinase N2 [Homo sapiens]                          1964   0.0  
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]               1078   0.0  
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]               1076   0.0  
gi|40254851 protein kinase PKNbeta [Homo sapiens]                     877   0.0  
gi|4885563 protein kinase C, epsilon [Homo sapiens]                   351   2e-96
gi|28557781 protein kinase C, eta [Homo sapiens]                      332   8e-91
gi|5453976 protein kinase C, theta [Homo sapiens]                     332   1e-90
gi|4506067 protein kinase C, alpha [Homo sapiens]                     331   2e-90
gi|4502023 AKT2 kinase [Homo sapiens]                                 327   4e-89
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]           326   6e-89
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]           324   3e-88
gi|62241015 AKT1 kinase [Homo sapiens]                                320   5e-87
gi|62241013 AKT1 kinase [Homo sapiens]                                320   5e-87
gi|62241011 AKT1 kinase [Homo sapiens]                                320   5e-87
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       315   2e-85
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      313   4e-85
gi|47157325 protein kinase C, delta [Homo sapiens]                    311   3e-84
gi|31377782 protein kinase C, delta [Homo sapiens]                    311   3e-84
gi|13384594 protein kinase C, gamma [Homo sapiens]                    306   6e-83
gi|133908623 protein kinase C, iota [Homo sapiens]                    300   6e-81
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]           288   1e-77
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]           288   1e-77
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]           288   1e-77
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho...   273   4e-73
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   268   1e-71
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   268   1e-71
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   268   2e-71
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   268   2e-71
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   268   2e-71
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   268   2e-71

>gi|5453974 protein kinase N2 [Homo sapiens]
          Length = 984

 Score = 1964 bits (5088), Expect = 0.0
 Identities = 984/984 (100%), Positives = 984/984 (100%)

Query: 1   MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKEL 60
           MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKEL
Sbjct: 1   MASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKEL 60

Query: 61  KIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPR 120
           KIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPR
Sbjct: 61  KIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPR 120

Query: 121 TPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLL 180
           TPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLL
Sbjct: 121 TPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLL 180

Query: 181 QDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVM 240
           QDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVM
Sbjct: 181 QDSKTKIEVIRMQILQAVQTNELAFDNAKPVISPLELRMEELRHHFRIEFAVAEGAKNVM 240

Query: 241 KLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVA 300
           KLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVA
Sbjct: 241 KLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVA 300

Query: 301 ASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWS 360
           ASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWS
Sbjct: 301 ASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWS 360

Query: 361 PSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQK 420
           PSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQK
Sbjct: 361 PSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQK 420

Query: 421 FTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFN 480
           FTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFN
Sbjct: 421 FTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFN 480

Query: 481 PVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPV 540
           PVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPV
Sbjct: 481 PVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPV 540

Query: 541 PTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPG 600
           PTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPG
Sbjct: 541 PTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPG 600

Query: 601 QDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCC 660
           QDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCC
Sbjct: 601 QDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCC 660

Query: 661 AVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFL 720
           AVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFL
Sbjct: 661 AVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFL 720

Query: 721 VNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVY 780
           VNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVY
Sbjct: 721 VNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVY 780

Query: 781 RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDW 840
           RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDW
Sbjct: 781 RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDW 840

Query: 841 WGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRL 900
           WGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRL
Sbjct: 841 WGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRL 900

Query: 901 GASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPP 960
           GASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPP
Sbjct: 901 GASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPP 960

Query: 961 REPRILSEEEQEMFRDFDYIADWC 984
           REPRILSEEEQEMFRDFDYIADWC
Sbjct: 961 REPRILSEEEQEMFRDFDYIADWC 984


>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
          Length = 948

 Score = 1078 bits (2788), Expect = 0.0
 Identities = 585/997 (58%), Positives = 720/997 (72%), Gaps = 66/997 (6%)

Query: 2   ASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELK 61
           A+NP        EL+ + RS    E +  +   D +   VQQ+L+  ++R++REIRKELK
Sbjct: 4   ANNPSE-----QELESEPRSWSLLEQLG-LAGADLAAPGVQQQLELERERLRREIRKELK 57

Query: 62  IKEGAENLRKVTTDK-KSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPR 120
           +KEGAENLR+ TTD  +SL  V+ +L+ S+++L+ LH +LQEL+AH+V+ DP    D P+
Sbjct: 58  LKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQ 117

Query: 121 TPDTPNNDPRCSTSN-NRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQL 179
           +P      P CS +N +R+  L+KQL IELKVKQGAENMIQ YSNGS+KDRKL  TAQQ+
Sbjct: 118 SPGA--GGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQM 175

Query: 180 LQDSKTKIEVIRMQILQAVQTNELAFDNA------KPVISPLELRMEELRHHFRIEFAVA 233
           LQDSKTKI++IRMQ+ +A+Q  +L    A       P +  +ELR+EELRHHFR+E AVA
Sbjct: 176 LQDSKTKIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVA 235

Query: 234 EGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIII 293
           EGAKNV++LL + K  DRKA+SEAQ +  ES+QKL LL+ +LE+RL E+P +HPK R++ 
Sbjct: 236 EGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLR 295

Query: 294 EELSLVAASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATS 353
           EEL+  A+S   S R +       YSTL KPA LTGTLEVR++GC+D+ E +P  +   S
Sbjct: 296 EELA-AASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPW-NPTPS 353

Query: 354 VALPGWSPSETRSSFMSRTSK---SKSGS--SRNLLKTD-DLSNDVCAVLKLDNTVVGQT 407
           +  PG    ++R  F+SR ++   S+SGS   R+ LK + + +++V  VLKLDNTVVGQT
Sbjct: 354 MGGPG--TPDSRPPFLSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQT 411

Query: 408 SWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLE 467
           SWKP    +WDQ FTLEL+R+RELE++V+WRD R LCA+KFL+LEDFLDN+RH + L +E
Sbjct: 412 SWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDME 471

Query: 468 PQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPT 527
           PQG L AEVTF NPVIER P+L+RQKKIFSKQQGK F RA QMNI++ATW RL+RR IP 
Sbjct: 472 PQGCLVAEVTFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPN 531

Query: 528 VNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEI 587
              +GTFSP A   +            A    D +V KL+   + +  P           
Sbjct: 532 ATGTGTFSPGASPGSE-----------ARTTGDISVEKLNLGTDSDSSP----------- 569

Query: 588 DESSELRVLDIPGQDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQ 647
            +SS     D P   S     IQ      LP    E       S L  S +         
Sbjct: 570 QKSSR----DPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPL--------- 616

Query: 648 QRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKR 707
                 L+DF+  AVLGRGHFGKVLL+E++ + E+FAIKALKKGDIVARDEV+SLMCEKR
Sbjct: 617 -----TLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKR 671

Query: 708 IFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVV 767
           I   V S  HPFLVNLF CFQT EHVCFVMEY+AGGDLM+HIH+DVFSEPRA+FY+ACVV
Sbjct: 672 ILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVV 731

Query: 768 LGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 827
           LGLQ+LHEHKIVYRDLKLDNLLLDTEG+VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE
Sbjct: 732 LGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 791

Query: 828 VLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISI 887
           VLT+TSYTRAVDWWGLGVL+YEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS EAI I
Sbjct: 792 VLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGI 851

Query: 888 MRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFD 947
           MRRLLRRNPERRLG+SE+DAEDVKK PFFR + W AL+ +++ PPF+PT+ GR DVSNFD
Sbjct: 852 MRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFD 911

Query: 948 DEFTSEAPILTPPREPRILSEEEQEMFRDFDYIADWC 984
           +EFT EAP L+PPR+ R L+  EQ  F DFD++A  C
Sbjct: 912 EEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC 948


>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
          Length = 942

 Score = 1076 bits (2782), Expect = 0.0
 Identities = 581/984 (59%), Positives = 715/984 (72%), Gaps = 61/984 (6%)

Query: 15  LQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKEGAENLRKVTT 74
           +Q + RS    E +  +   D +   VQQ+L+  ++R++REIRKELK+KEGAENLR+ TT
Sbjct: 6   VQSEPRSWSLLEQLG-LAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATT 64

Query: 75  DK-KSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPRTPDTPNNDPRCST 133
           D  +SL  V+ +L+ S+++L+ LH +LQEL+AH+V+ DP    D P++P      P CS 
Sbjct: 65  DLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPGA--GGPTCSA 122

Query: 134 SN-NRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIRM 192
           +N +R+  L+KQL IELKVKQGAENMIQ YSNGS+KDRKL  TAQQ+LQDSKTKI++IRM
Sbjct: 123 TNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRM 182

Query: 193 QILQAVQTNELAFDNA------KPVISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSG 246
           Q+ +A+Q  +L    A       P +  +ELR+EELRHHFR+E AVAEGAKNV++LL + 
Sbjct: 183 QLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAA 242

Query: 247 KVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVAASPTLS 306
           K  DRKA+SEAQ +  ES+QKL LL+ +LE+RL E+P +HPK R++ EEL+  A+S   S
Sbjct: 243 KAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELA-AASSAAFS 301

Query: 307 PRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRS 366
            R +       YSTL KPA LTGTLEVR++GC+D+ E +P  +   S+  PG    ++R 
Sbjct: 302 TRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPW-NPTPSMGGPG--TPDSRP 358

Query: 367 SFMSRTSK---SKSGS--SRNLLKTD-DLSNDVCAVLKLDNTVVGQTSWKPISNQSWDQK 420
            F+SR ++   S+SGS   R+ LK + + +++V  VLKLDNTVVGQTSWKP    +WDQ 
Sbjct: 359 PFLSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAWDQS 418

Query: 421 FTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFN 480
           FTLEL+R+RELE++V+WRD R LCA+KFL+LEDFLDN+RH + L +EPQG L AEVTF N
Sbjct: 419 FTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRN 478

Query: 481 PVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPV 540
           PVIER P+L+RQKKIFSKQQGK F RA QMNI++ATW RL+RR IP    +GTFSP A  
Sbjct: 479 PVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSPGASP 538

Query: 541 PTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELRVLDIPG 600
            +            A    D +V KL+   + +  P            +SS     D P 
Sbjct: 539 GSE-----------ARTTGDISVEKLNLGTDSDSSP-----------QKSSR----DPPS 572

Query: 601 QDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCC 660
             S     IQ      LP    E       S L  S +               L+DF+  
Sbjct: 573 SPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPL--------------TLEDFKFL 618

Query: 661 AVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFL 720
           AVLGRGHFGKVLL+E++ + E+FAIKALKKGDIVARDEV+SLMCEKRI   V S  HPFL
Sbjct: 619 AVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFL 678

Query: 721 VNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVY 780
           VNLF CFQT EHVCFVMEY+AGGDLM+HIH+DVFSEPRA+FY+ACVVLGLQ+LHEHKIVY
Sbjct: 679 VNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVY 738

Query: 781 RDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDW 840
           RDLKLDNLLLDTEG+VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT+TSYTRAVDW
Sbjct: 739 RDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDW 798

Query: 841 WGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRL 900
           WGLGVL+YEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS EAI IMRRLLRRNPERRL
Sbjct: 799 WGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRL 858

Query: 901 GASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPP 960
           G+SE+DAEDVKK PFFR + W AL+ +++ PPF+PT+ GR DVSNFD+EFT EAP L+PP
Sbjct: 859 GSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPP 918

Query: 961 REPRILSEEEQEMFRDFDYIADWC 984
           R+ R L+  EQ  F DFD++A  C
Sbjct: 919 RDARPLTAAEQAAFLDFDFVAGGC 942


>gi|40254851 protein kinase PKNbeta [Homo sapiens]
          Length = 889

 Score =  877 bits (2267), Expect = 0.0
 Identities = 478/943 (50%), Positives = 621/943 (65%), Gaps = 81/943 (8%)

Query: 46  DDIKDRIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNA 105
           +D K+ I+R I+KELKIKEG ENLR+V TD++ L +V  +L+ SN++LE+LH +L+EL+A
Sbjct: 17  EDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQLHGELRELHA 76

Query: 106 HIVVSDPEDITDCPRTPDTPNNDPRCSTSNNR-LKALQKQLDIELKVKQGAENMIQMYSN 164
            I++  P      P  P      P       R L+AL++QL +ELKVKQGAENM    ++
Sbjct: 77  RILLPGPGP---GPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCAS 133

Query: 165 GSSKDRKLHGTAQQLLQDSKTKIEVIRMQI--LQAVQTNELAFDNAKPVISPLELRMEEL 222
           G+ K+RKL   AQQ+L+DS+ K+ ++RM+I  L+A         +  P   P EL  EEL
Sbjct: 134 GTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEA---------SGSPEPGP-ELLAEEL 183

Query: 223 RHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEV 282
           +H   +E AVAEGAKNV+KLL S +  DRKAL+EAQA+  ESSQKLDLL+ +LEQ L ++
Sbjct: 184 QHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQL 243

Query: 283 PKNHP-KSRIIIEELSLVAASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDI 341
           P  HP +SR+  E  + V   P  S             T  KP ALTGTL+VRL+GC+ +
Sbjct: 244 PPAHPLRSRVTRELRAAVPGYPQPS------------GTPVKPTALTGTLQVRLLGCEQL 291

Query: 342 LENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDLSNDVCAVLKLDN 401
           L  VPGRS A ++A    SPSE    ++   +K + G         +L+++V AVLK+DN
Sbjct: 292 LTAVPGRSPAAALAS---SPSE---GWLRTKAKHQRGRG-------ELASEVLAVLKVDN 338

Query: 402 TVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHG 461
            VVGQT W  ++ QSWDQ F + L+R+RELEI V+WRDWR LC V FLRLEDFLDN  H 
Sbjct: 339 RVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQ 398

Query: 462 MCLYLEPQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLV 521
           + L L PQG LFA+VTF +PVIERRP+LQRQ++IFSK++G+ FLRA QMN+ +A WGRLV
Sbjct: 399 LSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLV 458

Query: 522 RRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVT--KLDFDLEPEPPPAPP 579
              +P  +   T SP    P   P     + + + PA+ S     K     E  PPP PP
Sbjct: 459 MNLLPPCSSPSTISP----PKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPP 514

Query: 580 RASSLGEIDESSELRVLDIPGQDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQ 639
           R               L +P + +                  SE  P T +  +E    +
Sbjct: 515 R---------------LYLPQEPT------------------SEETPRTKRPHMEPRTRR 541

Query: 640 ELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEV 699
                 S  R    LQDFRC AVLGRGHFGKVLL ++K T + +AIKALKK ++++RDE+
Sbjct: 542 GPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEI 601

Query: 700 DSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRA 759
           +SL CEKRI E V    HPFL++L ACFQT  H CFV E+  GGDLMM IH DVF EP+A
Sbjct: 602 ESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQA 661

Query: 760 VFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCG 819
            FY ACVVLGLQ+LHE KI+YRDLKLDNLLLD +GF+KIADFGLCKEG+G+GDRTSTFCG
Sbjct: 662 RFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCG 721

Query: 820 TPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRF 879
           TPEFLAPEVLT+ +YTRAVDWWGLGVL+YEMLVGE PFPGD EEEVFD IVN +  YP F
Sbjct: 722 TPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGF 781

Query: 880 LSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRG 939
           LS + +  +++LL++ PE+RLGA E+DAE++K  PFFR  +W AL+ + ++PPF+PT+ G
Sbjct: 782 LSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCG 841

Query: 940 REDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYIAD 982
             D+  F+ EFT   P LTPP    +L+  +Q  FRDFD++++
Sbjct: 842 PADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSE 884


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score =  351 bits (900), Expect = 2e-96
 Identities = 184/412 (44%), Positives = 259/412 (62%), Gaps = 13/412 (3%)

Query: 576 PAPPRASSLGEIDESSELRVLDIPGQDSETVFDIQNDRNSILPKSQ--SEYKPDTPQSGL 633
           P P   SS  E D S             + + +++N+    L       E++  +   G 
Sbjct: 330 PQPASGSSPSEEDRSKSAPTSPC----DQEIKELENNIRKALSFDNRGEEHRAASSPDGQ 385

Query: 634 EYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDI 693
             S  +  E R+ Q + +  L +F    VLG+G FGKV+LAE K  +E++A+K LKK  I
Sbjct: 386 LMSPGENGEVRQGQAK-RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVI 444

Query: 694 VARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD- 752
           +  D+VD  M EKRI       +HP+L  L+ CFQTK+ + FVMEY  GGDLM  I    
Sbjct: 445 LQDDDVDCTMTEKRILALAR--KHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSR 502

Query: 753 VFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGD 812
            F EPR+ FYAA V   L +LH+H ++YRDLKLDN+LLD EG  K+ADFG+CKEG+  G 
Sbjct: 503 KFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGV 562

Query: 813 RTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVND 872
            T+TFCGTP+++APE+L E  Y  +VDWW LGVL+YEM+ G+ PF  D+E+++F+SI++D
Sbjct: 563 TTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHD 622

Query: 873 EVRYPRFLSTEAISIMRRLLRRNPERRLG--ASEKDAEDVKKHPFFRLIDWSALMDKKVK 930
           +V YP +LS EA+SI++  + +NP +RLG  AS+   + +K+HPFF+ IDW  L  KK+K
Sbjct: 623 DVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIK 682

Query: 931 PPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYIAD 982
           PPF P I+ + DV+NFD +FT E P+LT   E  I+ +  QE F+ F Y  +
Sbjct: 683 PPFKPRIKTKRDVNNFDQDFTREEPVLTLVDE-AIVKQINQEEFKGFSYFGE 733


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  332 bits (852), Expect = 8e-91
 Identities = 169/364 (46%), Positives = 236/364 (64%), Gaps = 11/364 (3%)

Query: 620 SQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNT 679
           S+S  +    +S  E +GI      R        + +F    VLG+G FGKV+LA  K T
Sbjct: 324 SRSTLRRQGKESSKEGNGIGVNSSNR------LGIDNFEFIRVLGKGSFGKVMLARVKET 377

Query: 680 NEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEY 739
            +++A+K LKK  I+  D+V+  M EKRI     +  HPFL  LF CFQT + + FVME+
Sbjct: 378 GDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN--HPFLTQLFCCFQTPDRLFFVMEF 435

Query: 740 AAGGDLMMHIHTDV-FSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKI 798
             GGDLM HI     F E RA FYAA ++  L +LH+  I+YRDLKLDN+LLD EG  K+
Sbjct: 436 VNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKL 495

Query: 799 ADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFP 858
           ADFG+CKEG+  G  T+TFCGTP+++APE+L E  Y  AVDWW +GVL+YEML G +PF 
Sbjct: 496 ADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFE 555

Query: 859 GDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAED-VKKHPFFR 917
            ++E+++F++I+NDEV YP +L  +A  I++  + +NP  RLG+  +  E  + +HPFF+
Sbjct: 556 AENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFK 615

Query: 918 LIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDF 977
            IDW+ L  ++++PPF P I+ REDVSNFD +F  E P+LTP  E   L    Q+ FR+F
Sbjct: 616 EIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGH-LPMINQDEFRNF 674

Query: 978 DYIA 981
            Y++
Sbjct: 675 SYVS 678


>gi|5453976 protein kinase C, theta [Homo sapiens]
          Length = 706

 Score =  332 bits (851), Expect = 1e-90
 Identities = 168/342 (49%), Positives = 228/342 (66%), Gaps = 8/342 (2%)

Query: 640 ELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEV 699
           EL   R   + +  ++DF    +LG+G FGKV LAE+K TN+ FAIKALKK  ++  D+V
Sbjct: 363 ELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDV 422

Query: 700 DSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPR 758
           +  M EKR+     +  HPFL ++F  FQTKE++ FVMEY  GGDLM HI +   F   R
Sbjct: 423 ECTMVEKRVLSL--AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR 480

Query: 759 AVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFC 818
           A FYAA ++LGLQ+LH   IVYRDLKLDN+LLD +G +KIADFG+CKE M    +T+TFC
Sbjct: 481 ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC 540

Query: 819 GTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPR 878
           GTP+++APE+L    Y  +VDWW  GVL+YEML+G+SPF G DEEE+F SI  D   YPR
Sbjct: 541 GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR 600

Query: 879 FLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIR 938
           +L  EA  ++ +L  R PE+RLG       D+++HP FR I+W  L  K++ PPF P ++
Sbjct: 601 WLEKEAKDLLVKLFVREPEKRLGV----RGDIRQHPLFREINWEELERKEIDPPFRPKVK 656

Query: 939 GREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYI 980
              D SNFD EF +E P L+   +  +++  +Q MFR+F ++
Sbjct: 657 SPFDCSNFDKEFLNEKPRLS-FADRALINSMDQNMFRNFSFM 697


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score =  331 bits (849), Expect = 2e-90
 Identities = 165/346 (47%), Positives = 231/346 (66%), Gaps = 7/346 (2%)

Query: 638 IQELEDRR--SQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVA 695
           I   EDR+  S    +  L DF    VLG+G FGKV+LA+ K T E++AIK LKK  ++ 
Sbjct: 318 ISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQ 377

Query: 696 RDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDVF 754
            D+V+  M EKR+   ++  + PFL  L +CFQT + + FVMEY  GGDLM HI     F
Sbjct: 378 DDDVECTMVEKRVLALLD--KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKF 435

Query: 755 SEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRT 814
            EP+AVFYAA + +GL +LH+  I+YRDLKLDN++LD+EG +KIADFG+CKE M  G  T
Sbjct: 436 KEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTT 495

Query: 815 STFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEV 874
            TFCGTP+++APE++    Y ++VDWW  GVL+YEML G+ PF G+DE+E+F SI+   V
Sbjct: 496 RTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNV 555

Query: 875 RYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFI 934
            YP+ LS EA+SI + L+ ++P +RLG   +   DV++H FFR IDW  L +++++PPF 
Sbjct: 556 SYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFK 615

Query: 935 PTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYI 980
           P + G+    NFD  FT   P+LTPP +  +++  +Q  F  F Y+
Sbjct: 616 PKVCGK-GAENFDKFFTRGQPVLTPP-DQLVIANIDQSDFEGFSYV 659


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  327 bits (837), Expect = 4e-89
 Identities = 172/394 (43%), Positives = 245/394 (62%), Gaps = 14/394 (3%)

Query: 596 LDIPGQDSETVFDIQNDRNSILPKSQSE----YKPDTPQSGLEYSGIQELEDRRSQQRFQ 651
           +D P +  E +  IQ   NS+  ++  E    YK  +P      S  +E+E   S+ R +
Sbjct: 90  VDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDS---STTEEMEVAVSKARAK 146

Query: 652 FNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFET 711
             + DF    +LG+G FGKV+L   K T   +A+K L+K  I+A+DEV   + E R+ + 
Sbjct: 147 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ- 205

Query: 712 VNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGL 770
             + RHPFL  L   FQT + +CFVMEYA GG+L  H+  + VF+E RA FY A +V  L
Sbjct: 206 --NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSAL 263

Query: 771 QYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 830
           +YLH   +VYRD+KL+NL+LD +G +KI DFGLCKEG+  G    TFCGTPE+LAPEVL 
Sbjct: 264 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 323

Query: 831 ETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR 890
           +  Y RAVDWWGLGV++YEM+ G  PF   D E +F+ I+ +E+R+PR LS EA S++  
Sbjct: 324 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAG 383

Query: 891 LLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEF 950
           LL+++P++RLG    DA++V +H FF  I+W  ++ KK+ PPF P +    D   FDDEF
Sbjct: 384 LLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEF 443

Query: 951 TSEAPILTPP---REPRILSEEEQEMFRDFDYIA 981
           T+++  +TPP       +L  +++  F  F Y A
Sbjct: 444 TAQSITITPPDRYDSLGLLELDQRTHFPQFSYSA 477


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score =  326 bits (836), Expect = 6e-89
 Identities = 158/332 (47%), Positives = 222/332 (66%), Gaps = 4/332 (1%)

Query: 649 RFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRI 708
           R +  L DF    VLG+G FGKV+L+E K T+E++A+K LKK  ++  D+V+  M EKR+
Sbjct: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393

Query: 709 FETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDVFSEPRAVFYAACVV 767
                  + PFL  L +CFQT + + FVMEY  GGDLM HI     F EP AVFYAA + 
Sbjct: 394 LALPG--KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451

Query: 768 LGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 827
           +GL +L    I+YRDLKLDN++LD+EG +KIADFG+CKE +  G  T TFCGTP+++APE
Sbjct: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511

Query: 828 VLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISI 887
           ++    Y ++VDWW  GVL+YEML G++PF G+DE+E+F SI+   V YP+ +S EA++I
Sbjct: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571

Query: 888 MRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFD 947
            + L+ ++P +RLG   +   D+K+H FFR IDW  L  K+++PP+ P  R + D SNFD
Sbjct: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFD 631

Query: 948 DEFTSEAPILTPPREPRILSEEEQEMFRDFDY 979
            EFT +   LTP  +  I++ ++ E F  F Y
Sbjct: 632 KEFTRQPVELTPTDKLFIMNLDQNE-FAGFSY 662


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score =  324 bits (830), Expect = 3e-88
 Identities = 156/333 (46%), Positives = 221/333 (66%), Gaps = 5/333 (1%)

Query: 649 RFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRI 708
           R +  L DF    VLG+G FGKV+L+E K T+E++A+K LKK  ++  D+V+  M EKR+
Sbjct: 334 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393

Query: 709 FETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDVFSEPRAVFYAACVV 767
                  + PFL  L +CFQT + + FVMEY  GGDLM HI     F EP AVFYAA + 
Sbjct: 394 LALPG--KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451

Query: 768 LGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 827
           +GL +L    I+YRDLKLDN++LD+EG +KIADFG+CKE +  G  T TFCGTP+++APE
Sbjct: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511

Query: 828 VLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISI 887
           ++    Y ++VDWW  GVL+YEML G++PF G+DE+E+F SI+   V YP+ +S EA++I
Sbjct: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571

Query: 888 MRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFD 947
            + L+ ++P +RLG   +   D+K+H FFR IDW  L  K+++PP+ P   GR +  NFD
Sbjct: 572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFD 630

Query: 948 DEFTSEAPILTPPREPRILSEEEQEMFRDFDYI 980
             FT   P+LTPP +  ++   +Q  F  F ++
Sbjct: 631 RFFTRHPPVLTPP-DQEVIRNIDQSEFEGFSFV 662


>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  320 bits (819), Expect = 5e-87
 Identities = 165/370 (44%), Positives = 233/370 (62%), Gaps = 8/370 (2%)

Query: 617 LPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEY 676
           L K + E       S  + SG +E+E   ++ + +  + +F    +LG+G FGKV+L + 
Sbjct: 110 LKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKE 169

Query: 677 KNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFV 736
           K T   +A+K LKK  IVA+DEV   + E R+ +   + RHPFL  L   FQT + +CFV
Sbjct: 170 KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ---NSRHPFLTALKYSFQTHDRLCFV 226

Query: 737 MEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHK-IVYRDLKLDNLLLDTEG 794
           MEYA GG+L  H+  + VFSE RA FY A +V  L YLH  K +VYRDLKL+NL+LD +G
Sbjct: 227 MEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG 286

Query: 795 FVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGE 854
            +KI DFGLCKEG+  G    TFCGTPE+LAPEVL +  Y RAVDWWGLGV++YEM+ G 
Sbjct: 287 HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR 346

Query: 855 SPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHP 914
            PF   D E++F+ I+ +E+R+PR L  EA S++  LL+++P++RLG   +DA+++ +H 
Sbjct: 347 LPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHR 406

Query: 915 FFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREP---RILSEEEQ 971
           FF  I W  + +KK+ PPF P +    D   FD+EFT++   +TPP +      +  E +
Sbjct: 407 FFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERR 466

Query: 972 EMFRDFDYIA 981
             F  F Y A
Sbjct: 467 PHFPQFSYSA 476


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  320 bits (819), Expect = 5e-87
 Identities = 165/370 (44%), Positives = 233/370 (62%), Gaps = 8/370 (2%)

Query: 617 LPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEY 676
           L K + E       S  + SG +E+E   ++ + +  + +F    +LG+G FGKV+L + 
Sbjct: 110 LKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKE 169

Query: 677 KNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFV 736
           K T   +A+K LKK  IVA+DEV   + E R+ +   + RHPFL  L   FQT + +CFV
Sbjct: 170 KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ---NSRHPFLTALKYSFQTHDRLCFV 226

Query: 737 MEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHK-IVYRDLKLDNLLLDTEG 794
           MEYA GG+L  H+  + VFSE RA FY A +V  L YLH  K +VYRDLKL+NL+LD +G
Sbjct: 227 MEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG 286

Query: 795 FVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGE 854
            +KI DFGLCKEG+  G    TFCGTPE+LAPEVL +  Y RAVDWWGLGV++YEM+ G 
Sbjct: 287 HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR 346

Query: 855 SPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHP 914
            PF   D E++F+ I+ +E+R+PR L  EA S++  LL+++P++RLG   +DA+++ +H 
Sbjct: 347 LPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHR 406

Query: 915 FFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREP---RILSEEEQ 971
           FF  I W  + +KK+ PPF P +    D   FD+EFT++   +TPP +      +  E +
Sbjct: 407 FFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERR 466

Query: 972 EMFRDFDYIA 981
             F  F Y A
Sbjct: 467 PHFPQFSYSA 476


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  320 bits (819), Expect = 5e-87
 Identities = 165/370 (44%), Positives = 233/370 (62%), Gaps = 8/370 (2%)

Query: 617 LPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEY 676
           L K + E       S  + SG +E+E   ++ + +  + +F    +LG+G FGKV+L + 
Sbjct: 110 LKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKE 169

Query: 677 KNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFV 736
           K T   +A+K LKK  IVA+DEV   + E R+ +   + RHPFL  L   FQT + +CFV
Sbjct: 170 KATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ---NSRHPFLTALKYSFQTHDRLCFV 226

Query: 737 MEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHK-IVYRDLKLDNLLLDTEG 794
           MEYA GG+L  H+  + VFSE RA FY A +V  L YLH  K +VYRDLKL+NL+LD +G
Sbjct: 227 MEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDG 286

Query: 795 FVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGE 854
            +KI DFGLCKEG+  G    TFCGTPE+LAPEVL +  Y RAVDWWGLGV++YEM+ G 
Sbjct: 287 HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR 346

Query: 855 SPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHP 914
            PF   D E++F+ I+ +E+R+PR L  EA S++  LL+++P++RLG   +DA+++ +H 
Sbjct: 347 LPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHR 406

Query: 915 FFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREP---RILSEEEQ 971
           FF  I W  + +KK+ PPF P +    D   FD+EFT++   +TPP +      +  E +
Sbjct: 407 FFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERR 466

Query: 972 EMFRDFDYIA 981
             F  F Y A
Sbjct: 467 PHFPQFSYSA 476


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  315 bits (806), Expect = 2e-85
 Identities = 159/371 (42%), Positives = 233/371 (62%), Gaps = 10/371 (2%)

Query: 617 LPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEY 676
           L + + E    +P S ++  G +E++   +  + +  + DF    +LG+G FGKV+L   
Sbjct: 109 LQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRK-TMNDFDYLKLLGKGTFGKVILVRE 167

Query: 677 KNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFV 736
           K + + +A+K LKK  I+A+DEV   + E R+ +   + RHPFL +L   FQTK+ +CFV
Sbjct: 168 KASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK---NTRHPFLTSLKYSFQTKDRLCFV 224

Query: 737 MEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGF 795
           MEY  GG+L  H+  + VFSE R  FY A +V  L YLH  KIVYRDLKL+NL+LD +G 
Sbjct: 225 MEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGH 284

Query: 796 VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGES 855
           +KI DFGLCKEG+       TFCGTPE+LAPEVL +  Y RAVDWWGLGV++YEM+ G  
Sbjct: 285 IKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 344

Query: 856 PFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPF 915
           PF   D E++F+ I+ +++++PR LS++A S++  LL ++P +RLG    DA+++ +H F
Sbjct: 345 PFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSF 404

Query: 916 FRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPRE-----PRILSEEE 970
           F  ++W  + DKK+ PPF P +    D   FD+EFT++   +TPP +        +  E 
Sbjct: 405 FSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNER 464

Query: 971 QEMFRDFDYIA 981
           +  F  F Y A
Sbjct: 465 RPHFPQFSYSA 475


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  313 bits (803), Expect = 4e-85
 Identities = 154/347 (44%), Positives = 226/347 (65%), Gaps = 5/347 (1%)

Query: 617 LPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEY 676
           L + + E    +P S ++  G +E++   +  + +  + DF    +LG+G FGKV+L   
Sbjct: 109 LQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRK-TMNDFDYLKLLGKGTFGKVILVRE 167

Query: 677 KNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFV 736
           K + + +A+K LKK  I+A+DEV   + E R+ +   + RHPFL +L   FQTK+ +CFV
Sbjct: 168 KASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK---NTRHPFLTSLKYSFQTKDRLCFV 224

Query: 737 MEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGF 795
           MEY  GG+L  H+  + VFSE R  FY A +V  L YLH  KIVYRDLKL+NL+LD +G 
Sbjct: 225 MEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGH 284

Query: 796 VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGES 855
           +KI DFGLCKEG+       TFCGTPE+LAPEVL +  Y RAVDWWGLGV++YEM+ G  
Sbjct: 285 IKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRL 344

Query: 856 PFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPF 915
           PF   D E++F+ I+ +++++PR LS++A S++  LL ++P +RLG    DA+++ +H F
Sbjct: 345 PFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSF 404

Query: 916 FRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPRE 962
           F  ++W  + DKK+ PPF P +    D   FD+EFT++   +TPP +
Sbjct: 405 FSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEK 451


>gi|47157325 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score =  311 bits (796), Expect = 3e-84
 Identities = 156/329 (47%), Positives = 217/329 (65%), Gaps = 8/329 (2%)

Query: 653 NLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV 712
           N+ +F    VLG+G FGKVLL E K   E FAIKALKK  ++  D+V+  M EKR+    
Sbjct: 345 NINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTL- 403

Query: 713 NSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDV-FSEPRAVFYAACVVLGLQ 771
            +  +PFL +L   FQTK+H+ FVME+  GGDLM HI     F   RA FYAA ++ GLQ
Sbjct: 404 -AAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQ 462

Query: 772 YLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTE 831
           +LH   I+YRDLKLDN+LLD +G +KIADFG+CKE +    R STFCGTP+++APE+L  
Sbjct: 463 FLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQG 522

Query: 832 TSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRL 891
             YT +VDWW  GVL+YEML+G+SPF GDDE+E+F+SI  D   YPR+++ E+  I+ +L
Sbjct: 523 LKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKL 582

Query: 892 LRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFT 951
             R P +RLG +     ++K HPFF+ I+W+ L  ++++PPF P ++   D SNFD EF 
Sbjct: 583 FEREPTKRLGVT----GNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFL 638

Query: 952 SEAPILTPPREPRILSEEEQEMFRDFDYI 980
           +E   L+   +  ++   +Q  F  F ++
Sbjct: 639 NEKARLS-YSDKNLIDSMDQSAFAGFSFV 666


>gi|31377782 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score =  311 bits (796), Expect = 3e-84
 Identities = 156/329 (47%), Positives = 217/329 (65%), Gaps = 8/329 (2%)

Query: 653 NLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV 712
           N+ +F    VLG+G FGKVLL E K   E FAIKALKK  ++  D+V+  M EKR+    
Sbjct: 345 NINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTL- 403

Query: 713 NSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDV-FSEPRAVFYAACVVLGLQ 771
            +  +PFL +L   FQTK+H+ FVME+  GGDLM HI     F   RA FYAA ++ GLQ
Sbjct: 404 -AAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQ 462

Query: 772 YLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTE 831
           +LH   I+YRDLKLDN+LLD +G +KIADFG+CKE +    R STFCGTP+++APE+L  
Sbjct: 463 FLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQG 522

Query: 832 TSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRL 891
             YT +VDWW  GVL+YEML+G+SPF GDDE+E+F+SI  D   YPR+++ E+  I+ +L
Sbjct: 523 LKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKL 582

Query: 892 LRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFT 951
             R P +RLG +     ++K HPFF+ I+W+ L  ++++PPF P ++   D SNFD EF 
Sbjct: 583 FEREPTKRLGVT----GNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFL 638

Query: 952 SEAPILTPPREPRILSEEEQEMFRDFDYI 980
           +E   L+   +  ++   +Q  F  F ++
Sbjct: 639 NEKARLS-YSDKNLIDSMDQSAFAGFSFV 666


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score =  306 bits (784), Expect = 6e-83
 Identities = 156/334 (46%), Positives = 212/334 (63%), Gaps = 6/334 (1%)

Query: 651 QFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFE 710
           + ++ DF    VLG+G FGKV+LAE + ++E++AIK LKK  IV  D+VD  + EKR+  
Sbjct: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404

Query: 711 TVN---SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPRAVFYAACV 766
                   R  FL  L + FQT + + FVMEY  GGDLM HI     F EP A FYAA +
Sbjct: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464

Query: 767 VLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 826
            +GL +LH   I+YRDLKLDN++LD EG +KI DFG+CKE +  G  T TFCGTP+++AP
Sbjct: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524

Query: 827 EVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAIS 886
           E++    Y ++VDWW  GVL+YEML G+ PF G+DEEE+F +I+   V YP+ LS EA++
Sbjct: 525 EIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVA 584

Query: 887 IMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNF 946
           I +  L ++P +RLG+       ++ H FFR IDW  L   ++ PPF P   GR    NF
Sbjct: 585 ICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSG-ENF 643

Query: 947 DDEFTSEAPILTPPREPRILSEEEQEMFRDFDYI 980
           D  FT  AP LTPP +  +L+  +Q  F+ F Y+
Sbjct: 644 DKFFTRAAPALTPP-DRLVLASIDQADFQGFTYV 676


>gi|133908623 protein kinase C, iota [Homo sapiens]
          Length = 596

 Score =  300 bits (767), Expect = 6e-81
 Identities = 158/389 (40%), Positives = 232/389 (59%), Gaps = 27/389 (6%)

Query: 616 ILPKSQSEYKPDTPQSGLEYS-GIQELEDRRSQQRFQFN------------LQDFRCCAV 662
           ++P  QS    D  Q+ + Y+    E  D+  +++   N            LQDF    V
Sbjct: 200 VMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRV 259

Query: 663 LGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVN 722
           +GRG + KVLL   K T+ ++A+K +KK  +   +++D +  EK +FE  ++  HPFLV 
Sbjct: 260 IGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN--HPFLVG 317

Query: 723 LFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHKIVYR 781
           L +CFQT+  + FV+EY  GGDLM H+       E  A FY+A + L L YLHE  I+YR
Sbjct: 318 LHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYR 377

Query: 782 DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWW 841
           DLKLDN+LLD+EG +K+ D+G+CKEG+  GD TSTFCGTP ++APE+L    Y  +VDWW
Sbjct: 378 DLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWW 437

Query: 842 GLGVLIYEMLVGESPF---------PGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLL 892
            LGVL++EM+ G SPF           + E+ +F  I+  ++R PR LS +A S+++  L
Sbjct: 438 ALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFL 497

Query: 893 RRNPERRLGASEKDA-EDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFT 951
            ++P+ RLG   +    D++ HPFFR +DW  +  K+V PPF P I G   + NFD +FT
Sbjct: 498 NKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFT 557

Query: 952 SEAPILTPPREPRILSEEEQEMFRDFDYI 980
           +E P+   P +  I+ + +Q  F  F+YI
Sbjct: 558 NE-PVQLTPDDDDIVRKIDQSEFEGFEYI 585


>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  288 bits (738), Expect = 1e-77
 Identities = 160/394 (40%), Positives = 228/394 (57%), Gaps = 25/394 (6%)

Query: 597 DIPGQDSETVFDIQNDRNSILPKSQSE-YKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQ 655
           D+P ++++ +  I + R     K  SE  KP     G++   I +             LQ
Sbjct: 20  DLPSEETDGIAYISSSRKHDSIKDDSEDLKPVI--DGMDGIKISQ----------GLGLQ 67

Query: 656 DFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSV 715
           DF    V+GRG + KVLL   K  ++++A+K +KK  +   +++D +  EK +FE  +S 
Sbjct: 68  DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS- 126

Query: 716 RHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLH 774
            +PFLV L +CFQT   +  V+EY  GGDLM H+       E  A FYAA + + L +LH
Sbjct: 127 -NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185

Query: 775 EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSY 834
           E  I+YRDLKLDN+LLD +G +K+ D+G+CKEG+G GD TSTFCGTP ++APE+L    Y
Sbjct: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245

Query: 835 TRAVDWWGLGVLIYEMLVGESPF-------PGDDEEEVFDSIVNDEVRYPRFLSTEAISI 887
             +VDWW LGVL++EM+ G SPF         + E+ +F  I+   +R PRFLS +A  +
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305

Query: 888 MRRLLRRNPERRLGASEKDA-EDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNF 946
           ++  L ++P+ RLG   +    D+K H FFR IDW  L  K+  PPF P I     + NF
Sbjct: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365

Query: 947 DDEFTSEAPILTPPREPRILSEEEQEMFRDFDYI 980
           D +FTSE   LTP  E  I   ++ E F  F+YI
Sbjct: 366 DTQFTSEPVQLTPDDEDAIKRIDQSE-FEGFEYI 398


>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  288 bits (738), Expect = 1e-77
 Identities = 160/394 (40%), Positives = 228/394 (57%), Gaps = 25/394 (6%)

Query: 597 DIPGQDSETVFDIQNDRNSILPKSQSE-YKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQ 655
           D+P ++++ +  I + R     K  SE  KP     G++   I +             LQ
Sbjct: 20  DLPSEETDGIAYISSSRKHDSIKDDSEDLKPVI--DGMDGIKISQ----------GLGLQ 67

Query: 656 DFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSV 715
           DF    V+GRG + KVLL   K  ++++A+K +KK  +   +++D +  EK +FE  +S 
Sbjct: 68  DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS- 126

Query: 716 RHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLH 774
            +PFLV L +CFQT   +  V+EY  GGDLM H+       E  A FYAA + + L +LH
Sbjct: 127 -NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185

Query: 775 EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSY 834
           E  I+YRDLKLDN+LLD +G +K+ D+G+CKEG+G GD TSTFCGTP ++APE+L    Y
Sbjct: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245

Query: 835 TRAVDWWGLGVLIYEMLVGESPF-------PGDDEEEVFDSIVNDEVRYPRFLSTEAISI 887
             +VDWW LGVL++EM+ G SPF         + E+ +F  I+   +R PRFLS +A  +
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305

Query: 888 MRRLLRRNPERRLGASEKDA-EDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNF 946
           ++  L ++P+ RLG   +    D+K H FFR IDW  L  K+  PPF P I     + NF
Sbjct: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365

Query: 947 DDEFTSEAPILTPPREPRILSEEEQEMFRDFDYI 980
           D +FTSE   LTP  E  I   ++ E F  F+YI
Sbjct: 366 DTQFTSEPVQLTPDDEDAIKRIDQSE-FEGFEYI 398


>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
          Length = 592

 Score =  288 bits (738), Expect = 1e-77
 Identities = 160/394 (40%), Positives = 228/394 (57%), Gaps = 25/394 (6%)

Query: 597 DIPGQDSETVFDIQNDRNSILPKSQSE-YKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQ 655
           D+P ++++ +  I + R     K  SE  KP     G++   I +             LQ
Sbjct: 203 DLPSEETDGIAYISSSRKHDSIKDDSEDLKPVI--DGMDGIKISQ----------GLGLQ 250

Query: 656 DFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSV 715
           DF    V+GRG + KVLL   K  ++++A+K +KK  +   +++D +  EK +FE  +S 
Sbjct: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS- 309

Query: 716 RHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLH 774
            +PFLV L +CFQT   +  V+EY  GGDLM H+       E  A FYAA + + L +LH
Sbjct: 310 -NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368

Query: 775 EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSY 834
           E  I+YRDLKLDN+LLD +G +K+ D+G+CKEG+G GD TSTFCGTP ++APE+L    Y
Sbjct: 369 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 428

Query: 835 TRAVDWWGLGVLIYEMLVGESPF-------PGDDEEEVFDSIVNDEVRYPRFLSTEAISI 887
             +VDWW LGVL++EM+ G SPF         + E+ +F  I+   +R PRFLS +A  +
Sbjct: 429 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 488

Query: 888 MRRLLRRNPERRLGASEKDA-EDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNF 946
           ++  L ++P+ RLG   +    D+K H FFR IDW  L  K+  PPF P I     + NF
Sbjct: 489 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 548

Query: 947 DDEFTSEAPILTPPREPRILSEEEQEMFRDFDYI 980
           D +FTSE   LTP  E  I   ++ E F  F+YI
Sbjct: 549 DTQFTSEPVQLTPDDEDAIKRIDQSE-FEGFEYI 581


>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
           sapiens]
          Length = 525

 Score =  273 bits (699), Expect = 4e-73
 Identities = 141/331 (42%), Positives = 209/331 (63%), Gaps = 12/331 (3%)

Query: 657 FRCCAVLGRGHFGKVLLAEY---KNTNEMFAIKALKKGDIV--ARDEVDSLMCEKRIFET 711
           F    VLG+G +GKV         NT ++FA+K LKK  IV  A+D   +   E+ I E 
Sbjct: 91  FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHT-KAERNILE- 148

Query: 712 VNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGL 770
              V+HPF+V+L   FQT   +  ++EY +GG+L M +  + +F E  A FY A + + L
Sbjct: 149 --EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMAL 206

Query: 771 QYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 830
            +LH+  I+YRDLK +N++L+ +G VK+ DFGLCKE +  G  T TFCGT E++APE+L 
Sbjct: 207 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 266

Query: 831 ETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR 890
            + + RAVDWW LG L+Y+ML G  PF G++ ++  D I+  ++  P +L+ EA  ++++
Sbjct: 267 RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKK 326

Query: 891 LLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEF 950
           LL+RN   RLGA   DA +V+ HPFFR I+W  L+ +KV+PPF P ++  EDVS FD +F
Sbjct: 327 LLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKF 386

Query: 951 TSEAPILTPPREPRILSEEEQEMFRDFDYIA 981
           T + P+ +P  +   LSE   ++F  F Y+A
Sbjct: 387 TRQTPVDSP--DDSTLSESANQVFLGFTYVA 415


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  268 bits (686), Expect = 1e-71
 Identities = 147/352 (41%), Positives = 208/352 (59%), Gaps = 22/352 (6%)

Query: 618 PKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQ---------------DFRCCAV 662
           P  ++  + D+P+     S   E ED RS Q+     Q               DF    V
Sbjct: 111 PDVRAFLQMDSPK---HQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKV 167

Query: 663 LGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVN 722
           +G+G FGKVLLA+ K   + +A+K L+K  ++ R E   +M E+ +   + +V+HPFLV 
Sbjct: 168 IGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVL--LKNVKHPFLVG 225

Query: 723 LFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHKIVYR 781
           L   FQT E + FV+++  GG+L  H+  +  F E RA FYAA +   L YLH  KIVYR
Sbjct: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285

Query: 782 DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWW 841
           DLK +N+LLD+ G V + DFGLCKEG+   D T+TFCGTPE+LAPEV+ +  Y   VDWW
Sbjct: 286 DLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWW 345

Query: 842 GLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLG 901
            LG ++YEML G  PF   D  E++D+I++  +     +S  A SI+  LL ++ + RLG
Sbjct: 346 CLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLG 405

Query: 902 ASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSE 953
           A E D  +++ HPFF  + W+ L+ KK+ PPF P + G +D+ NFD  FT E
Sbjct: 406 AKE-DFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEE 456


>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  268 bits (686), Expect = 1e-71
 Identities = 147/352 (41%), Positives = 208/352 (59%), Gaps = 22/352 (6%)

Query: 618 PKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQ---------------DFRCCAV 662
           P  ++  + D+P+     S   E ED RS Q+     Q               DF    V
Sbjct: 111 PDVRAFLQMDSPK---HQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKV 167

Query: 663 LGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVN 722
           +G+G FGKVLLA+ K   + +A+K L+K  ++ R E   +M E+ +   + +V+HPFLV 
Sbjct: 168 IGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVL--LKNVKHPFLVG 225

Query: 723 LFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHKIVYR 781
           L   FQT E + FV+++  GG+L  H+  +  F E RA FYAA +   L YLH  KIVYR
Sbjct: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285

Query: 782 DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWW 841
           DLK +N+LLD+ G V + DFGLCKEG+   D T+TFCGTPE+LAPEV+ +  Y   VDWW
Sbjct: 286 DLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWW 345

Query: 842 GLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLG 901
            LG ++YEML G  PF   D  E++D+I++  +     +S  A SI+  LL ++ + RLG
Sbjct: 346 CLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLG 405

Query: 902 ASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSE 953
           A E D  +++ HPFF  + W+ L+ KK+ PPF P + G +D+ NFD  FT E
Sbjct: 406 AKE-DFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEE 456


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  268 bits (684), Expect = 2e-71
 Identities = 134/299 (44%), Positives = 193/299 (64%), Gaps = 4/299 (1%)

Query: 656 DFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSV 715
           DF    V+G+G FGKVLLA +K     +A+K L+K  I+ + E   +M E+ +   + +V
Sbjct: 97  DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVL--LKNV 154

Query: 716 RHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLH 774
           +HPFLV L   FQT + + FV++Y  GG+L  H+  +  F EPRA FYAA +   L YLH
Sbjct: 155 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 214

Query: 775 EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSY 834
              IVYRDLK +N+LLD++G + + DFGLCKE + +   TSTFCGTPE+LAPEVL +  Y
Sbjct: 215 SLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY 274

Query: 835 TRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRR 894
            R VDWW LG ++YEML G  PF   +  E++D+I+N  ++    ++  A  ++  LL++
Sbjct: 275 DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQK 334

Query: 895 NPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSE 953
           +  +RLGA + D  ++K H FF LI+W  L++KK+ PPF P + G  D+ +FD EFT E
Sbjct: 335 DRTKRLGAKD-DFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 392


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  268 bits (684), Expect = 2e-71
 Identities = 134/299 (44%), Positives = 193/299 (64%), Gaps = 4/299 (1%)

Query: 656 DFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSV 715
           DF    V+G+G FGKVLLA +K     +A+K L+K  I+ + E   +M E+ +   + +V
Sbjct: 111 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVL--LKNV 168

Query: 716 RHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLH 774
           +HPFLV L   FQT + + FV++Y  GG+L  H+  +  F EPRA FYAA +   L YLH
Sbjct: 169 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 228

Query: 775 EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSY 834
              IVYRDLK +N+LLD++G + + DFGLCKE + +   TSTFCGTPE+LAPEVL +  Y
Sbjct: 229 SLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY 288

Query: 835 TRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRR 894
            R VDWW LG ++YEML G  PF   +  E++D+I+N  ++    ++  A  ++  LL++
Sbjct: 289 DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQK 348

Query: 895 NPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSE 953
           +  +RLGA + D  ++K H FF LI+W  L++KK+ PPF P + G  D+ +FD EFT E
Sbjct: 349 DRTKRLGAKD-DFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 406


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  268 bits (684), Expect = 2e-71
 Identities = 134/299 (44%), Positives = 193/299 (64%), Gaps = 4/299 (1%)

Query: 656 DFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSV 715
           DF    V+G+G FGKVLLA +K     +A+K L+K  I+ + E   +M E+ +   + +V
Sbjct: 125 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVL--LKNV 182

Query: 716 RHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLH 774
           +HPFLV L   FQT + + FV++Y  GG+L  H+  +  F EPRA FYAA +   L YLH
Sbjct: 183 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 242

Query: 775 EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSY 834
              IVYRDLK +N+LLD++G + + DFGLCKE + +   TSTFCGTPE+LAPEVL +  Y
Sbjct: 243 SLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY 302

Query: 835 TRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRR 894
            R VDWW LG ++YEML G  PF   +  E++D+I+N  ++    ++  A  ++  LL++
Sbjct: 303 DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQK 362

Query: 895 NPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSE 953
           +  +RLGA + D  ++K H FF LI+W  L++KK+ PPF P + G  D+ +FD EFT E
Sbjct: 363 DRTKRLGAKD-DFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 420


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  268 bits (684), Expect = 2e-71
 Identities = 134/299 (44%), Positives = 193/299 (64%), Gaps = 4/299 (1%)

Query: 656 DFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSV 715
           DF    V+G+G FGKVLLA +K     +A+K L+K  I+ + E   +M E+ +   + +V
Sbjct: 192 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVL--LKNV 249

Query: 716 RHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLH 774
           +HPFLV L   FQT + + FV++Y  GG+L  H+  +  F EPRA FYAA +   L YLH
Sbjct: 250 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLH 309

Query: 775 EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSY 834
              IVYRDLK +N+LLD++G + + DFGLCKE + +   TSTFCGTPE+LAPEVL +  Y
Sbjct: 310 SLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY 369

Query: 835 TRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRR 894
            R VDWW LG ++YEML G  PF   +  E++D+I+N  ++    ++  A  ++  LL++
Sbjct: 370 DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQK 429

Query: 895 NPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSE 953
           +  +RLGA + D  ++K H FF LI+W  L++KK+ PPF P + G  D+ +FD EFT E
Sbjct: 430 DRTKRLGAKD-DFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEE 487


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,556,723
Number of Sequences: 37866
Number of extensions: 1781415
Number of successful extensions: 10769
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 688
Number of HSP's successfully gapped in prelim test: 263
Number of HSP's that attempted gapping in prelim test: 7829
Number of HSP's gapped (non-prelim): 1531
length of query: 984
length of database: 18,247,518
effective HSP length: 112
effective length of query: 872
effective length of database: 14,006,526
effective search space: 12213690672
effective search space used: 12213690672
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.