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Search of human proteins with 5453726
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5453726 leucine rich repeat (in FLII) interacting protein 2
isoform 1 [Homo sapiens]
(721 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5453726 leucine rich repeat (in FLII) interacting protein 2 i... 1401 0.0
gi|212276078 leucine rich repeat (in FLII) interacting protein 1... 566 e-161
gi|197276647 leucine rich repeat (in FLII) interacting protein 2... 503 e-142
gi|8923224 leucine rich repeat (in FLII) interacting protein 2 i... 405 e-113
gi|212276088 leucine rich repeat (in FLII) interacting protein 1... 293 4e-79
gi|212276096 leucine rich repeat (in FLII) interacting protein 1... 207 4e-53
gi|212276070 leucine rich repeat (in FLII) interacting protein 1... 157 3e-38
gi|212276104 leucine rich repeat (in FLII) interacting protein 1... 150 4e-36
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 78 3e-14
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 75 2e-13
gi|30260188 Golgi autoantigen, golgin subfamily a, 5 [Homo sapiens] 73 8e-13
gi|34577114 cytomatrix protein p110 [Homo sapiens] 73 1e-12
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 72 1e-12
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 72 1e-12
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 70 9e-12
gi|31982906 cingulin-like 1 [Homo sapiens] 69 1e-11
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 69 1e-11
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 69 2e-11
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 69 2e-11
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 69 2e-11
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 69 2e-11
gi|42794779 myosin 18A isoform b [Homo sapiens] 68 3e-11
gi|28416946 myosin 18A isoform a [Homo sapiens] 68 3e-11
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 68 3e-11
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 68 3e-11
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 68 3e-11
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 68 3e-11
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 67 4e-11
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 67 6e-11
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 67 6e-11
>gi|5453726 leucine rich repeat (in FLII) interacting protein 2
isoform 1 [Homo sapiens]
Length = 721
Score = 1401 bits (3627), Expect = 0.0
Identities = 721/721 (100%), Positives = 721/721 (100%)
Query: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEY 60
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEY
Sbjct: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEY 60
Query: 61 SLHSFDRKWGQIQKWLEDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYDMFKDRSSR 120
SLHSFDRKWGQIQKWLEDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYDMFKDRSSR
Sbjct: 61 SLHSFDRKWGQIQKWLEDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYDMFKDRSSR 120
Query: 121 LSSLNHSYSHSHGMKKRSSDSHKDLLSGLYFDQRNYSSLRHSKPTSAYYTRQSSSLYSDP 180
LSSLNHSYSHSHGMKKRSSDSHKDLLSGLYFDQRNYSSLRHSKPTSAYYTRQSSSLYSDP
Sbjct: 121 LSSLNHSYSHSHGMKKRSSDSHKDLLSGLYFDQRNYSSLRHSKPTSAYYTRQSSSLYSDP 180
Query: 181 LATYKSDRASPTANSGLLRSASLASLYNGGLYNPYGPRTPSECSYYSSRISSARSSPGFT 240
LATYKSDRASPTANSGLLRSASLASLYNGGLYNPYGPRTPSECSYYSSRISSARSSPGFT
Sbjct: 181 LATYKSDRASPTANSGLLRSASLASLYNGGLYNPYGPRTPSECSYYSSRISSARSSPGFT 240
Query: 241 NDDTASIVSSDRASRGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDLSSLDEKSDKQY 300
NDDTASIVSSDRASRGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDLSSLDEKSDKQY
Sbjct: 241 NDDTASIVSSDRASRGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDLSSLDEKSDKQY 300
Query: 301 AENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGR 360
AENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGR
Sbjct: 301 AENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGR 360
Query: 361 YMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRE 420
YMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRE
Sbjct: 361 YMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRE 420
Query: 421 NEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETL 480
NEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETL
Sbjct: 421 NEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETL 480
Query: 481 LWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSH 540
LWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSH
Sbjct: 481 LWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSH 540
Query: 541 EPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSR 600
EPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSR
Sbjct: 541 EPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSR 600
Query: 601 NDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLR 660
NDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLR
Sbjct: 601 NDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLR 660
Query: 661 YKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 720
YKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ
Sbjct: 661 YKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 720
Query: 721 Q 721
Q
Sbjct: 721 Q 721
>gi|212276078 leucine rich repeat (in FLII) interacting protein 1
isoform 1 [Homo sapiens]
Length = 640
Score = 567 bits (1460), Expect = e-161
Identities = 343/730 (46%), Positives = 453/730 (62%), Gaps = 101/730 (13%)
Query: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEY 60
MGT SGRKR P ++R +AED+AL+ IAREAEARLAAKRAARAEAR+IRM+ELERQQKE
Sbjct: 3 MGTQGSGRKRLPNRERLTAEDDALNQIAREAEARLAAKRAARAEAREIRMKELERQQKEI 62
Query: 61 -----SLHSFDRKWGQIQKWLEDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYDMFK 115
+ D KWG I++W+EDSER YS RS + ++ +S+ S GS R
Sbjct: 63 YQVQKKYYGLDTKWGDIEQWMEDSER--YSRRSRRNTSASDEDERMSVGSRGSLR----- 115
Query: 116 DRSSRLSSLNHSYSHSHGMKKRSSDSHKDL-LSGLYFDQRNYSSLRHSKPTSAYYTRQSS 174
S DL G Y Y Y ++ +
Sbjct: 116 -------------------------SQPDLEYGGPYAWTNGYDG-------ELYGSQSLN 143
Query: 175 SLYSDPLATYKSDRASPTANSGLLRSASLASLYNGGLYNPYGPRTPSECSYYSSRISSAR 234
P Y + R S + + +L S G + G R PSE YS ++S+
Sbjct: 144 RRSGRPSCLYSAARPSGSYRASVLDEGSFGGTRRG---STSGSRAPSE---YSGHLNSSS 197
Query: 235 SSPGFTNDDTASIVSSDRASRGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDLSSLDE 294
+ S RAS R VV +E
Sbjct: 198 RA-------------SSRASSARASPVV------------------------------EE 214
Query: 295 KSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQI 354
+ +K + E +R SA+ L G SSRRGSGDTS ID + S+ E++++ +LKDQI
Sbjct: 215 RPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQI 274
Query: 355 QDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQM 414
QDVEG+YMQGLKE+K+SL+EVEEKYKKAMVSNAQLDNEK N +YQVDTLKD++ E EEQ+
Sbjct: 275 QDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQL 334
Query: 415 AEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVF 474
AE R+ EEK+KE ER+KH S+LQ + E+KE L+QR+E++EE +++QQK + +E+
Sbjct: 335 AESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIREIS 394
Query: 475 DLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTP 534
DLQET+ WKDKKIGALE+QKE+ +R+ERD LREE+ L+E +K KHG+++ +
Sbjct: 395 DLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELK---KHGIILNSEIAT 451
Query: 535 NGDVS---HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQL 591
NG+ S + T +++E L+S G+G LD+RL+KL E+E LL QI+KLK QL
Sbjct: 452 NGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQL 511
Query: 592 EEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSI 651
EERQK + D + L+NG+D+ +++QRDANRQIS+ KFKL+K+EQ+IT LEQ++
Sbjct: 512 -EERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNV 570
Query: 652 SRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 711
RLE QV RYK+AAENAEK+EDELKAEKRKLQRELR+ALDK EE+E++N HL KRLEKMK
Sbjct: 571 IRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMK 630
Query: 712 ANRTALLAQQ 721
ANR+ALL+QQ
Sbjct: 631 ANRSALLSQQ 640
>gi|197276647 leucine rich repeat (in FLII) interacting protein 2
isoform 3 [Homo sapiens]
Length = 424
Score = 503 bits (1294), Expect = e-142
Identities = 291/447 (65%), Positives = 330/447 (73%), Gaps = 69/447 (15%)
Query: 279 SEVDDISIPDLS----SLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL 334
+E DI + +L LDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL
Sbjct: 43 AEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL 102
Query: 335 IDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKN 394
IDPDTSLSELRDIYDLK + + +VE +Y + +
Sbjct: 103 IDPDTSLSELRDIYDLK------------------DQIQDVEGRYMQGLKE--------- 135
Query: 395 NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDE 454
LK+ + E EE+ Y++ + +L+ +K+ L ++++ LK+ + +++E
Sbjct: 136 --------LKESLSEVEEK----YKKAMVSNAQLDNEKNN---LIYQVDTLKDVIEEQEE 180
Query: 455 LIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADL 514
+ E R ++ K LE+QK + L+++ + L+E L
Sbjct: 181 QMAEFYRENEE--------------------KSKELERQKHMCSVLQHKMEELKEGLRQR 220
Query: 515 QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLA 574
E + EKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLA
Sbjct: 221 DELI---EKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLA 277
Query: 575 GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK 634
GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK
Sbjct: 278 GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK 337
Query: 635 FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIE 694
FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIE
Sbjct: 338 FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIE 397
Query: 695 EMEMTNSHLAKRLEKMKANRTALLAQQ 721
EMEMTNSHLAKRLEKMKANRTALLAQQ
Sbjct: 398 EMEMTNSHLAKRLEKMKANRTALLAQQ 424
Score = 114 bits (285), Expect = 3e-25
Identities = 59/59 (100%), Positives = 59/59 (100%)
Query: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKE 59
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKE
Sbjct: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKE 59
>gi|8923224 leucine rich repeat (in FLII) interacting protein 2
isoform 2 [Homo sapiens]
Length = 400
Score = 405 bits (1040), Expect = e-113
Identities = 232/362 (64%), Positives = 266/362 (73%), Gaps = 16/362 (4%)
Query: 365 LKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEK 424
++EL+ E++EK K N + +N+ + + +
Sbjct: 50 MRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSL 109
Query: 425 SKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWK- 483
S+ E L E+ K+ + +L EK + ++DT+ K+V + QE + +
Sbjct: 110 SELRES-------LSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL-KDVIEEQEEQMAEF 161
Query: 484 ----DKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVS 539
++K LE+QK + L+++ + L+E L E + EKHGLVIIPDGTPNGDVS
Sbjct: 162 YRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELI---EKHGLVIIPDGTPNGDVS 218
Query: 540 HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCS 599
HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCS
Sbjct: 219 HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCS 278
Query: 600 RNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVL 659
RNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVL
Sbjct: 279 RNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVL 338
Query: 660 RYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLA 719
RYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLA
Sbjct: 339 RYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLA 398
Query: 720 QQ 721
QQ
Sbjct: 399 QQ 400
Score = 266 bits (680), Expect = 5e-71
Identities = 146/184 (79%), Positives = 150/184 (81%), Gaps = 28/184 (15%)
Query: 279 SEVDDISIPDLS----SLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL 334
+E DI + +L LDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL
Sbjct: 43 AEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL 102
Query: 335 IDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKN 394
IDPDTSLSELR ESLSEVEEKYKKAMVSNAQLDNEKN
Sbjct: 103 IDPDTSLSELR------------------------ESLSEVEEKYKKAMVSNAQLDNEKN 138
Query: 395 NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDE 454
NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDE
Sbjct: 139 NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDE 198
Query: 455 LIEE 458
LIE+
Sbjct: 199 LIEK 202
Score = 114 bits (286), Expect = 2e-25
Identities = 77/145 (53%), Positives = 88/145 (60%), Gaps = 12/145 (8%)
Query: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEY 60
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKE
Sbjct: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKE- 59
Query: 61 SLHSFDRKWGQIQKWLEDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYDMFKDRSSR 120
D K +++ E+ R + +S P G + GS D +
Sbjct: 60 ----LDEK--SDKQYAENYTRPSSRNSASATTPLSG-----NSSRRGSGDTSSLIDPDTS 108
Query: 121 LSSLNHSYSHSHGMKKRSSDSHKDL 145
LS L S S K++ S+ L
Sbjct: 109 LSELRESLSEVEEKYKKAMVSNAQL 133
>gi|212276088 leucine rich repeat (in FLII) interacting protein 1
isoform 2 [Homo sapiens]
Length = 394
Score = 293 bits (750), Expect = 4e-79
Identities = 187/447 (41%), Positives = 257/447 (57%), Gaps = 91/447 (20%)
Query: 279 SEVDDISIPDLSSLDEKSDKQYAENYTRPSSRN----SASATTPLSGNSSRRGSGDTSSL 334
+E +I + +L ++ +++ +++T SRN SA+ L G SSRRGSGDTS
Sbjct: 35 AEAREIRMKELERQQKEVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSIS 94
Query: 335 IDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKN 394
ID + S+ +E+K+SL+EVEEKYKKAMVSNAQLDNEK
Sbjct: 95 IDTEASI------------------------REIKDSLAEVEEKYKKAMVSNAQLDNEKT 130
Query: 395 NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDE 454
N +YQVDTLKD++ E EEQ+AE R+ EEK+KE ER+KH S+LQ + E+KE L+QR+E
Sbjct: 131 NFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREE 190
Query: 455 LIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADL 514
++E+ + E D + + + M +EEL L
Sbjct: 191 MLEKHGIILNSEIATNGETSDTLNNVGY------------------QGPTKMTKEELNAL 232
Query: 515 QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLA 574
+ T GD G + + ++ E E +++KL
Sbjct: 233 KST------------------GD-------GTLDIRLKKLVDERECLLE-----QIKKLK 262
Query: 575 GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK 634
G+ EE RQK + D + L+NG+D+ +++QRDANRQIS+ K
Sbjct: 263 GQLEE---------------RQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLK 307
Query: 635 FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIE 694
FKL+K+EQ+IT LEQ++ RLE QV RYK+AAENAEK+EDELKAEKRKLQRELR+ALDK E
Sbjct: 308 FKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTE 367
Query: 695 EMEMTNSHLAKRLEKMKANRTALLAQQ 721
E+E++N HL KRLEKMKANR+ALL+QQ
Sbjct: 368 ELEVSNGHLVKRLEKMKANRSALLSQQ 394
Score = 56.6 bits (135), Expect = 8e-08
Identities = 39/94 (41%), Positives = 51/94 (54%), Gaps = 17/94 (18%)
Query: 18 SAEDEALSNIARE-AEARLAAKRAARAEARDIRMRELERQQKEYSLHSFDRKWGQIQKWL 76
S E + LS A++ AEARLAAKRAARAEAR+IRM+ELERQQKE +
Sbjct: 9 SREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKE----------------V 52
Query: 77 EDSERARYSHRSSHHRPYLGVEDALSIRSVGSHR 110
E+ ++ + S + P L S+ S R
Sbjct: 53 EERPEKDFTEKGSRNMPGLSAATLASLGGTSSRR 86
>gi|212276096 leucine rich repeat (in FLII) interacting protein 1
isoform 3 [Homo sapiens]
Length = 808
Score = 207 bits (526), Expect = 4e-53
Identities = 108/204 (52%), Positives = 150/204 (73%), Gaps = 3/204 (1%)
Query: 258 RESVVSAADYFSRSNRRGSVVSEVDD-ISIPDLSSL--DEKSDKQYAENYTRPSSRNSAS 314
R+ ++ +SR +RR + S+ D+ +S+ SL +E+ +K + E +R SA+
Sbjct: 47 RQQKEEDSERYSRRSRRNTSASDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAA 106
Query: 315 ATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSE 374
L G SSRRGSGDTS ID + S+ E++++ +LKDQIQDVEG+YMQGLKE+K+SL+E
Sbjct: 107 TLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAE 166
Query: 375 VEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHM 434
VEEKYKKAMVSNAQLDNEK N +YQVDTLKD++ E EEQ+AE R+ EEK+KE ER+KH
Sbjct: 167 VEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHA 226
Query: 435 CSVLQHKMEELKEGLRQRDELIEE 458
S+LQ + E+KE L+QR+E++E+
Sbjct: 227 HSILQFQFAEVKEALKQREEMLEK 250
Score = 62.8 bits (151), Expect = 1e-09
Identities = 46/96 (47%), Positives = 57/96 (59%), Gaps = 20/96 (20%)
Query: 18 SAEDEALSNIARE-AEARLAAKRAARAEARDIRMRELERQQKEYSLHSFDRKWGQIQKWL 76
S E + LS A++ AEARLAAKRAARAEAR+IRM+ELERQQKE
Sbjct: 9 SREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKE----------------- 51
Query: 77 EDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYD 112
EDSE RYS RS + ++ +S+ S GS R +
Sbjct: 52 EDSE--RYSRRSRRNTSASDEDERMSVGSRGSLRVE 85
>gi|212276070 leucine rich repeat (in FLII) interacting protein 1
isoform 4 [Homo sapiens]
Length = 784
Score = 157 bits (397), Expect = 3e-38
Identities = 91/204 (44%), Positives = 128/204 (62%), Gaps = 27/204 (13%)
Query: 258 RESVVSAADYFSRSNRRGSVVSEVDD-ISIPDLSSL--DEKSDKQYAENYTRPSSRNSAS 314
R+ ++ +SR +RR + S+ D+ +S+ SL +E+ +K + E +R SA+
Sbjct: 47 RQQKEEDSERYSRRSRRNTSASDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAA 106
Query: 315 ATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSE 374
L G SSRRGSGDTS ID + S+ +E+K+SL+E
Sbjct: 107 TLASLGGTSSRRGSGDTSISIDTEASI------------------------REIKDSLAE 142
Query: 375 VEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHM 434
VEEKYKKAMVSNAQLDNEK N +YQVDTLKD++ E EEQ+AE R+ EEK+KE ER+KH
Sbjct: 143 VEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHA 202
Query: 435 CSVLQHKMEELKEGLRQRDELIEE 458
S+LQ + E+KE L+QR+E++E+
Sbjct: 203 HSILQFQFAEVKEALKQREEMLEK 226
Score = 62.8 bits (151), Expect = 1e-09
Identities = 46/96 (47%), Positives = 57/96 (59%), Gaps = 20/96 (20%)
Query: 18 SAEDEALSNIARE-AEARLAAKRAARAEARDIRMRELERQQKEYSLHSFDRKWGQIQKWL 76
S E + LS A++ AEARLAAKRAARAEAR+IRM+ELERQQKE
Sbjct: 9 SREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKE----------------- 51
Query: 77 EDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYD 112
EDSE RYS RS + ++ +S+ S GS R +
Sbjct: 52 EDSE--RYSRRSRRNTSASDEDERMSVGSRGSLRVE 85
>gi|212276104 leucine rich repeat (in FLII) interacting protein 1
isoform 5 [Homo sapiens]
Length = 752
Score = 150 bits (379), Expect = 4e-36
Identities = 84/184 (45%), Positives = 118/184 (64%), Gaps = 28/184 (15%)
Query: 279 SEVDDISIPDLSSLDEKSDKQYAENYTRPSSRN----SASATTPLSGNSSRRGSGDTSSL 334
+E +I + +L ++ +++ +++T SRN SA+ L G SSRRGSGDTS
Sbjct: 35 AEAREIRMKELERQQKEVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSIS 94
Query: 335 IDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKN 394
ID + S+ +E+K+SL+EVEEKYKKAMVSNAQLDNEK
Sbjct: 95 IDTEASI------------------------REIKDSLAEVEEKYKKAMVSNAQLDNEKT 130
Query: 395 NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDE 454
N +YQVDTLKD++ E EEQ+AE R+ EEK+KE ER+KH S+LQ + E+KE L+QR+E
Sbjct: 131 NFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREE 190
Query: 455 LIEE 458
++E+
Sbjct: 191 MLEK 194
Score = 56.6 bits (135), Expect = 8e-08
Identities = 39/94 (41%), Positives = 51/94 (54%), Gaps = 17/94 (18%)
Query: 18 SAEDEALSNIARE-AEARLAAKRAARAEARDIRMRELERQQKEYSLHSFDRKWGQIQKWL 76
S E + LS A++ AEARLAAKRAARAEAR+IRM+ELERQQKE +
Sbjct: 9 SREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKE----------------V 52
Query: 77 EDSERARYSHRSSHHRPYLGVEDALSIRSVGSHR 110
E+ ++ + S + P L S+ S R
Sbjct: 53 EERPEKDFTEKGSRNMPGLSAATLASLGGTSSRR 86
Score = 43.1 bits (100), Expect = 9e-04
Identities = 52/237 (21%), Positives = 112/237 (47%), Gaps = 23/237 (9%)
Query: 443 EELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRN 502
E+ K+ + +L EK ++DT+ + +L+E L ++ EK KE+ ++
Sbjct: 113 EKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYE--EKNKEF-EREKH 169
Query: 503 ERDMLREELADLQETVKTG----EKHGLVIIPDGTPNGDVS---HEPVAGAITVVSQEAA 555
+L+ + A+++E +K EKHG+++ + NG+ S + T +++E
Sbjct: 170 AHSILQFQFAEVKEALKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEEL 229
Query: 556 QVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGS 615
L+S G+G L R ++ K E+++ + K ++ E+++ + TV D ++
Sbjct: 230 NALKSTGDGTLG-RASEVE-VKNEIVANVGKREILHNTEKEQ--HTEDTVKDCVDIEVFP 285
Query: 616 DLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVE 672
+ E Q+ ++ + + L+ A T E+ + + Q+L + EN +VE
Sbjct: 286 AGENTEDQK-SSEDTAPFLGTLAGA-----TYEEQV---QSQILESSSLPENTVQVE 333
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 77.8 bits (190), Expect = 3e-14
Identities = 95/448 (21%), Positives = 198/448 (44%), Gaps = 70/448 (15%)
Query: 323 SSRRGSGDTSSLIDPDTSLSELR-DIYDLKDQI----QDVEGRYMQG------------- 364
+ R+ G+T+ L D ++EL+ I +LK Q+ ++++G +G
Sbjct: 1056 AKRKLDGETTDLQD---QIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKV 1112
Query: 365 LKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEE--------------Q 410
++EL+ ++E++E ++ S + + +K +L +++ LK +E+ +
Sbjct: 1113 VRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR 1172
Query: 411 EEQMAEFYRENEEKSKELE------RQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQ 464
E+++AE + EE++K E RQ+H + L+ E+L++ R + L + KQ ++
Sbjct: 1173 EQEVAELKKALEEETKNHEAQIQDMRQRH-ATALEELSEQLEQAKRFKANLEKNKQGLET 1231
Query: 465 KIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKH 524
+ EV LQ+ + K L+ Q + + +E D LR ELA+ ++ +
Sbjct: 1232 DNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDN 1291
Query: 525 GLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDV--RLRKLAGEK----- 577
++ + G + A ++ Q+ ++L+ L++ R+R+L EK
Sbjct: 1292 VSTLLEEAEKKG-IKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350
Query: 578 ---------EELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANR 628
+ L Q+ L+ QL + ++K + GT+ L + + ++ ++
Sbjct: 1351 QQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK----KLLKDAEALSQ 1406
Query: 629 QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVE---DELKAEKRKLQRE 685
++ E K E+ L+Q + L + + A N EK + D+L AE++ +
Sbjct: 1407 RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISAR 1466
Query: 686 LRTALDKIE----EMEMTNSHLAKRLEK 709
D+ E E E LA+ LE+
Sbjct: 1467 YAEERDRAEAEAREKETKALSLARALEE 1494
Score = 72.8 bits (177), Expect = 1e-12
Identities = 87/412 (21%), Positives = 177/412 (42%), Gaps = 59/412 (14%)
Query: 338 DTSLSELR-DIYDLKDQIQDVEGRY------MQGLKELKE----SLSEVEEKYKKAMVSN 386
+ + E+R + +L+D++Q E MQ +K E + E E+ K+ ++
Sbjct: 1538 EQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQ 1597
Query: 387 -----AQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHK 441
A+L++E+ V + K + + ++ A+ N+ + + +++ + + + ++
Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDY 1657
Query: 442 MEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIA--- 498
EL+E RDE+ + + ++K+ ++ E+ LQE L ++ E++++ +A
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEI 1717
Query: 499 --------CLRNERDMLREELADLQETVKTGEKHGLVIIPD---------GTPNGDVSHE 541
L +E+ L +A L+E ++ E+ + ++ D T N +++ E
Sbjct: 1718 TNSASGKSALLDEKRRLEARIAQLEEELEE-EQSNMELLNDRFRKTTLQVDTLNAELAAE 1776
Query: 542 PVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGE-KEELLSQIRKLKL---QLEEERQK 597
A S A Q LE + L +L++L G K + + I L+ QLEE+ ++
Sbjct: 1777 RSAAQ---KSDNARQQLERQNK-ELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ 1832
Query: 598 CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQ 657
++ L + D R +YK ++ KA + L++ +
Sbjct: 1833 EAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQL------ 1886
Query: 658 VLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 709
E AE+ A +RKLQREL A + E + S L RL +
Sbjct: 1887 --------EEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 65.5 bits (158), Expect = 2e-10
Identities = 79/381 (20%), Positives = 163/381 (42%), Gaps = 44/381 (11%)
Query: 349 DLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIE 408
+L + +++ R +EL+E L ++E + ++ N L NEK + + L++ ++
Sbjct: 901 ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLD 960
Query: 409 EQEEQMAEFYREN---EEKSKELERQKHMCSVLQHKMEELKEGLRQR-----DELIEEKQ 460
E+E + E E K K++E + + K + K+ + R +L EE++
Sbjct: 961 EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEE 1020
Query: 461 RMQQKIDTMTKE---VFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQET 517
+ + K+ + DL+E L ++K LEK K L E L++++A+LQ
Sbjct: 1021 KAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK---LDGETTDLQDQIAELQAQ 1077
Query: 518 V---------KTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDV 568
+ K E G + GD A+ VV + AQ+ E + +
Sbjct: 1078 IDELKLQLAKKEEELQGAL------ARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131
Query: 569 RLR-KLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDAN 627
R K +K +L ++ LK +LE+ T L+ + + E+++
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLD-------TTAAQQELRTKREQEVAELKKALE 1184
Query: 628 RQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELR 687
+ ++ ++ Q T + +S Q R+K N EK + L+ + ++L E++
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKA---NLEKNKQGLETDNKELACEVK 1241
Query: 688 TALDKIEEMEMTNSHLAKRLE 708
+++++ + H K+L+
Sbjct: 1242 V----LQQVKAESEHKRKKLD 1258
Score = 63.5 bits (153), Expect = 6e-10
Identities = 99/401 (24%), Positives = 181/401 (45%), Gaps = 84/401 (20%)
Query: 350 LKDQIQDVEGRYMQGLKE---LKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDV 406
++ +++++E ++ Q L+E L E L E + +A A+L +K L + L+
Sbjct: 871 VEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESR 930
Query: 407 IEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKI 466
+EE+EE+ +NE+K + Q L+ +++E +EG RQ+ +L EK + KI
Sbjct: 931 VEEEEERNQIL--QNEKKKMQAHIQD-----LEEQLDE-EEGARQKLQL--EKVTAEAKI 980
Query: 467 DTMTKEVFDL--QETLLWKDKKI------------GALEKQKEYIACLRNERDMLREELA 512
M +E+ L Q + K+KK+ E++ + +A +RN+++++ ++
Sbjct: 981 KKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVM---IS 1037
Query: 513 DLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRK 572
DL+E +K EK Q LE A + LD
Sbjct: 1038 DLEERLKKEEK------------------------------TRQELEKA-KRKLDGETTD 1066
Query: 573 LAGEKEELLSQIRKLKLQL---EEERQKCSR--NDGTVGDLAGLQNGSDLQ--FIEMQRD 625
L + EL +QI +LKLQL EEE Q +D T+ L+ +LQ E+Q D
Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQED 1126
Query: 626 ANRQISEYKFKLSKAEQDIT------------TLEQSISRLEGQVLRYKTAAENAEKVED 673
+ + + K K ++D++ TL+ + ++ E + R + AE + +E+
Sbjct: 1127 FESEKAS-RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE 1185
Query: 674 ELK---AEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 711
E K A+ + +++ TAL+++ E LEK K
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226
Score = 63.5 bits (153), Expect = 6e-10
Identities = 81/409 (19%), Positives = 176/409 (43%), Gaps = 68/409 (16%)
Query: 349 DLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNA----QLDNEKNNLIYQVDTLK 404
D K ++ D G ++ L+E K+ L + E + + A +L+ KN L ++D L
Sbjct: 1375 DTKKKVDDDLGT-IESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLT 1433
Query: 405 DVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRD-------ELIE 457
++ Q + + ++ ++ + L +K + + + + + R+++ +E
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493
Query: 458 EKQRMQQKIDTMTKEV-FDLQETLLWKD---KKIGALEKQKEYIACLRNERDMLREELAD 513
E +++ + K++ D+++ + KD K + LEK K L + + +R +L +
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR---ALEQQVEEMRTQLEE 1550
Query: 514 LQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKL 573
L++ ++ E L + + Q +++ E L R +
Sbjct: 1551 LEDELQATEDAKLRL-----------------------EVNMQAMKAQFERDLQTRDEQN 1587
Query: 574 AGEKEELLSQIRKLKLQLEEERQK-----CSRNDGTVGDLAGLQ------NGSDLQFIEM 622
+K L+ Q+R+L+ +LE+ER++ S+ + DL L+ N + + I+
Sbjct: 1588 EEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI-DLKDLEAQIEAANKARDEVIKQ 1646
Query: 623 QRDANRQISEYKFKLSKA--------------EQDITTLEQSISRLEGQVLRYKTAAENA 668
R Q+ +Y+ +L +A E+ + +LE I +L+ ++ + A +A
Sbjct: 1647 LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHA 1706
Query: 669 EKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTAL 717
E+ DEL E LD+ +E + L + LE+ ++N L
Sbjct: 1707 EQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL 1755
Score = 58.2 bits (139), Expect = 3e-08
Identities = 65/316 (20%), Positives = 139/316 (43%), Gaps = 41/316 (12%)
Query: 397 IYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELI 456
+ QV ++ ++ ++E++ + + + ELE + L + L E L+ EL
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 457 EEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQE 516
E + M+ ++ +E L+E L + ++ E+++E L+NE+ ++ + DL+E
Sbjct: 904 AEAEEMRARLAAKKQE---LEEILHDLESRV---EEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 517 TVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGE 576
+ E+ G + E V + E +L L+ + K E
Sbjct: 958 QLD--EEEGA--------RQKLQLEKVTAEAKIKKMEEEILL-------LEDQNSKFIKE 1000
Query: 577 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFK 636
K+ + +I + QL EE +K +LA ++N ++ IS+ + +
Sbjct: 1001 KKLMEDRIAECSSQLAEEEEKAK-------NLAKIRNKQEVM-----------ISDLEER 1042
Query: 637 LSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEM 696
L K E+ LE++ +L+G+ + + DELK + K + EL+ AL + ++
Sbjct: 1043 LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDE 1102
Query: 697 EMTNSHLAKRLEKMKA 712
+ ++ K + +++A
Sbjct: 1103 TLHKNNALKVVRELQA 1118
Score = 53.9 bits (128), Expect = 5e-07
Identities = 81/441 (18%), Positives = 180/441 (40%), Gaps = 21/441 (4%)
Query: 294 EKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDP--DTSLSELRDIYDLK 351
+K D Q E + + S + + + + S+L++ + +D L+
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314
Query: 352 DQIQDVEGRYMQGLKE---LKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIE 408
Q+QD + + ++ L + ++EE+ + + + NL QV L+ +
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA 1374
Query: 409 EQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDT 468
+ ++++ + E E +K + + + L+E D+L + K R+QQ++D
Sbjct: 1375 DTKKKVDDDLGTIESLE---EAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD 1431
Query: 469 MTKEVFDLQET---LLWKDKKIGAL-EKQKEYIACLRNERDMLREELADLQETVKTGEKH 524
+T ++ ++ L K KK L ++K A ERD E + +ET
Sbjct: 1432 LTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEARE-KETKALSLAR 1490
Query: 525 GLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQI 584
L + + ++ + + + V ++ E L+ R L + EE+ +Q+
Sbjct: 1491 ALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE--LEKSKRALEQQVEEMRTQL 1548
Query: 585 RKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANR-----QISEYKFKLSK 639
+L+ +L+ R + + + Q DLQ + Q + + Q+ E + +L
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQAMKA-QFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 640 AEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMT 699
+ S ++E + + E A K DE+ + RKLQ +++ ++EE +
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS 1667
Query: 700 NSHLAKRLEKMKANRTALLAQ 720
+ + ++ + +L A+
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAE 1688
Score = 45.8 bits (107), Expect = 1e-04
Identities = 59/270 (21%), Positives = 114/270 (42%), Gaps = 30/270 (11%)
Query: 461 RMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKT 520
R ++++ +E+ ++E + K G LE+ + L E+++L E+L E
Sbjct: 849 RQEEELQAKDEELLKVKEK---QTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 521 GEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEEL 580
E+ + ++ H+ LES E + R + L EK+++
Sbjct: 906 AEEMRARLAAKKQELEEILHD----------------LESRVEEE-EERNQILQNEKKKM 948
Query: 581 LSQIRKLKLQLEEE---RQKCSRNDGT-------VGDLAGLQNGSDLQFIEMQRDANRQI 630
+ I+ L+ QL+EE RQK T + + L + +FI+ ++ +I
Sbjct: 949 QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI 1008
Query: 631 SEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTAL 690
+E +L++ E+ L + ++ E + + + EK EL+ KRKL E
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068
Query: 691 DKIEEMEMTNSHLAKRLEKMKANRTALLAQ 720
D+I E++ L +L K + LA+
Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALAR 1098
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 75.5 bits (184), Expect = 2e-13
Identities = 115/530 (21%), Positives = 220/530 (41%), Gaps = 67/530 (12%)
Query: 249 SSDRASRGRRESVVSAADYFSRSNRRGSVVSEVDDIS--IPDLSSLDEKSDKQYAENYTR 306
S+ R R S D + + G S + +P + SL K E+ R
Sbjct: 30 STPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIK---ESLFR 86
Query: 307 PSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLK 366
SS+ S T+ + T+S P SE D+ D + + + +Q L+
Sbjct: 87 SSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLN--KEQLIQRLR 144
Query: 367 ELKESLSEVEEKYKKAMVSNAQLDNEKNNL-----IYQVDTLKDVIEEQEE-QMAEFYRE 420
++ SLS KY + + + L EK L Q +L+ + E +EE QM + ++
Sbjct: 145 RMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKK 204
Query: 421 N--EEKSKELERQKHMCSVLQHKMEELKEGLR---QRDELIEEKQRMQQKIDTMTKEV-- 473
+ EE LE + SVLQ ++ LK+ LR ++++ +++ + + TKE
Sbjct: 205 HLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENP 264
Query: 474 -----------------------FDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREE 510
QE LL + K+ ++ KE L +E++ L+E+
Sbjct: 265 ESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKE--TIQSHKEQCTLLTSEKEALQEQ 322
Query: 511 LAD-LQETVKTGEKHG------LVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGE 563
L + LQE K + H + + D + + I ++ + LE E
Sbjct: 323 LDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEE 382
Query: 564 --GPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKC-SRNDGTVGDLAGLQNGSDLQFI 620
L R++++ + EEL Q K + EE +K S T L+ D Q
Sbjct: 383 EIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIK 442
Query: 621 EMQRDANRQISEYKFKLSKAEQDITTL-----EQSISRLEGQVLRYKTAAENAEKVEDEL 675
+++ + + + +LS+ +Q++ + E+ I++L Q L K A +++ +L
Sbjct: 443 TIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL--QKLHEKELARKEQELTKKL 500
Query: 676 KAEKRKLQRELRTALDKIEEMEMTNSHLAKR-----LEKMKANRTALLAQ 720
+ +R+ Q +++ AL+K + + S ++ LE+++ + A+L +
Sbjct: 501 QTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTE 550
Score = 59.7 bits (143), Expect = 9e-09
Identities = 85/372 (22%), Positives = 175/372 (47%), Gaps = 43/372 (11%)
Query: 366 KELKESLSEVE-EKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEK 424
KE +ESL+ E E KKA+++ ++ N+ +L + +T + I E E + + +EN+ +
Sbjct: 529 KEQQESLALEELELQKKAILTESE--NKLRDLQQEAETYRTRILELESSLEKSLQENKNQ 586
Query: 425 SKEL------ERQKH---MCSVLQHKMEELKEGLRQRDELIEE-----KQRMQQKIDTMT 470
SK+L E+ KH + +++ EL+ Q+D L E KQ+ Q +++ +
Sbjct: 587 SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR 646
Query: 471 KEVFDLQETLLWKDKKI-------GALEKQKEYIACLRNERDMLREELADLQETVKTGEK 523
++ +ETLL KDK+I EK E + + E + L EL+++ + E+
Sbjct: 647 EKCEQEKETLL-KDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEE 705
Query: 524 HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQ 583
L ++ D T + E A + QV E + ++ + A L Q
Sbjct: 706 E-LSVLKDQTDK--MKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKA-----LKDQ 757
Query: 584 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQ-RDANRQISEYKFKLSKAEQ 642
I +L+L L+E + + V +L +D++ E + + A+ ++ ++ S +
Sbjct: 758 INQLELLLKERDKHLKEHQAHVENLE-----ADIKRSEGELQQASAKLDVFQSYQSATHE 812
Query: 643 DITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRT----ALDKIEEMEM 698
E+ +++L+ ++L +T K E++A+K+ + EL D ++++E
Sbjct: 813 QTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEK 872
Query: 699 TNSHLAKRLEKM 710
NS + ++++ +
Sbjct: 873 QNSEMEQKVKSL 884
Score = 55.8 bits (133), Expect = 1e-07
Identities = 79/444 (17%), Positives = 177/444 (39%), Gaps = 45/444 (10%)
Query: 292 LDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDL- 350
L+ +K EN S L ++ T + T L L+ D
Sbjct: 572 LESSLEKSLQEN-----KNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDAL 626
Query: 351 -KDQIQDVEGRYMQGLKELKESLSEVEEKY--KKAMVSNAQLDNEKNNLIYQVDTLKDVI 407
+++Q ++ +Y +++L+E + +E K ++ A ++ + ++D + +
Sbjct: 627 WTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTEL 686
Query: 408 EEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKID 467
E +++E + + +EL SVL+ + +++K+ L + + E+K QQ++D
Sbjct: 687 ESLSSELSEVLKARHKLEEEL-------SVLKDQTDKMKQELEAKMD--EQKNHHQQQVD 737
Query: 468 TMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLV 527
++ KE E + + +K AL+ Q + L ERD +E E ++ K
Sbjct: 738 SIIKE----HEVSIQRTEK--ALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG 791
Query: 528 IIPDGTPNGDV--SHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIR 585
+ + DV S++ T +E L+ +L L E+ L Q+
Sbjct: 792 ELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQ--------KLLDLETERILLTKQVA 843
Query: 586 KLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDIT 645
+++ Q ++ C+ D + L + Q EM++ Y+ KL ++
Sbjct: 844 EVEAQ---KKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
Query: 646 TLEQSISRLEGQVLRYKTA--------AENAEKVEDELKAEKRKLQRELRTALDKIEEME 697
+Q + E +L+ + + ED + + + + + K+E+++
Sbjct: 901 QTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVK 960
Query: 698 MTNSHLAKRLEKMKANRTALLAQQ 721
+ + L+K ++ A L ++
Sbjct: 961 QKAKEMQETLKKKLLDQEAKLKKE 984
Score = 53.1 bits (126), Expect = 9e-07
Identities = 83/401 (20%), Positives = 168/401 (41%), Gaps = 56/401 (13%)
Query: 333 SLIDPDTSLSELRDIYD-----LKDQIQDVEGRYMQGLKELKESLSEVE-------EKYK 380
SL + + ++S LR YD L DQ+QD+ + KE +L +V+ E K
Sbjct: 1388 SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKK 1447
Query: 381 KAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQH 440
KA Q N L Q++ E++EQ+ E ++++K + K +
Sbjct: 1448 KAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKS 1507
Query: 441 KMEELKEGLRQRDELIEEKQRMQQKIDTMTK---EVFDLQETL----LWKDKKIGALEKQ 493
KME+ + L EL + R+ + D +T+ E+ L E L KD + L ++
Sbjct: 1508 KMEKKESNL--ETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQK 1565
Query: 494 KEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPD-GTPNGDVSHEPVAGAITVVSQ 552
++ L E+D + + +E + T E + + T ++ H ++ +
Sbjct: 1566 LQHFQELGEEKD---NRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLS---VKSKE 1619
Query: 553 EAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQ 612
E + LE E +L +L + E+ ++ I+K L EE+++
Sbjct: 1620 EELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEE--------------- 1664
Query: 613 NGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLE---GQVLRYKTAAENAE 669
+ ++ +SE KL + E+++ LE+ + +E + L +A+N
Sbjct: 1665 --------QYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVA 1716
Query: 670 KVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKM 710
++ +A+ + + +T +KI ++ + K L+++
Sbjct: 1717 AYTEQEEADSQGCVQ--KTYEEKISVLQRNLTEKEKLLQRV 1755
Score = 52.0 bits (123), Expect = 2e-06
Identities = 77/437 (17%), Positives = 182/437 (41%), Gaps = 67/437 (15%)
Query: 341 LSELRDIYDLKDQIQDVEG-------RYMQGLKELKES-LSEVEEKYKKAMVSNAQLDNE 392
+++LRD +L +Q++ +G R M E+KE ++++ + K+ +L +
Sbjct: 345 ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQ 404
Query: 393 KNN----LIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELER---------QKHMCSVLQ 439
K +++ ++ EE + E +E+ K +E+ Q+ + V Q
Sbjct: 405 KEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQ 464
Query: 440 HKMEELKEGLRQR---------DELIEEKQRMQQKIDTMTKEVFDLQETLLWKDK----K 486
++ +K+ ++ EL ++Q + +K+ T +E + + L K + K
Sbjct: 465 EVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLK 524
Query: 487 IGALEKQKEYIAC--------------------LRNERDMLREELADLQETVKTGEKHGL 526
I ++Q+E +A L+ E + R + +L+ +++ +
Sbjct: 525 ISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENK 584
Query: 527 VIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRK 586
D + + ITV+ ++ LES + KL K++ +++ K
Sbjct: 585 NQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEK 644
Query: 587 LKLQLEEERQKCSRNDGTVGDL-AGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDIT 645
L+ + E+E++ ++ + N L+ +++++ +S ++ KA
Sbjct: 645 LREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHK-- 702
Query: 646 TLEQSISRLEGQVLRYKTAAE---------NAEKVEDELKAEKRKLQRELRTALDKIEEM 696
LE+ +S L+ Q + K E + ++V+ +K + +QR + D+I ++
Sbjct: 703 -LEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL 761
Query: 697 EMTNSHLAKRLEKMKAN 713
E+ K L++ +A+
Sbjct: 762 ELLLKERDKHLKEHQAH 778
Score = 48.5 bits (114), Expect = 2e-05
Identities = 74/408 (18%), Positives = 169/408 (41%), Gaps = 83/408 (20%)
Query: 361 YMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK----DVIEEQEEQMAE 416
Y + L +L++ L ++E + A+++ +K ++ ++D K D++++ E+Q +E
Sbjct: 817 YEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSE 876
Query: 417 -----------FYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEK------ 459
+ + E+ +KE E+ K + ++ + +++EG ++ E++ +K
Sbjct: 877 MEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKED 936
Query: 460 -------------QRMQQKIDTMTKEVFDLQETL----------LWKDKKIGALE---KQ 493
+ ++K++ + ++ ++QETL L K+ + ALE K+
Sbjct: 937 SIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKE 996
Query: 494 KEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQE 553
K++ A + ++D ++T +K + + +V + I++ ++
Sbjct: 997 KQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLT------EVHRRELNDVISIWEKK 1050
Query: 554 AAQVLESAGE-------------GPLDVRLRKLAGEKEELLSQIRKLKLQ-------LEE 593
Q E E L ++ EKEE+ +I LK + L E
Sbjct: 1051 LNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNE 1110
Query: 594 ERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSK-------AEQD--- 643
+++ + V LA + +++ D N+ + E F + AE+D
Sbjct: 1111 LQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRK 1170
Query: 644 ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALD 691
++ L + + + K++ E + K ++ E +KL EL LD
Sbjct: 1171 VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLD 1218
Score = 47.8 bits (112), Expect = 4e-05
Identities = 86/403 (21%), Positives = 166/403 (41%), Gaps = 60/403 (14%)
Query: 350 LKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNL-IYQVDTLKDVIE 408
LKDQI +E + K LKE + VE S +L L ++Q + +
Sbjct: 754 LKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQ--SYQSATH 811
Query: 409 EQEEQMAEFYRENEEKSKELE---------------RQKHMCSVLQ-HK--MEELKEGLR 450
EQ + E + ++K +LE ++K +C+ L HK +++L + L
Sbjct: 812 EQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLE 871
Query: 451 QRDELIEEK-----QRMQQKIDTMTKEVFDLQETLLWKDKKIGAL-EKQKEYIACLRNER 504
+++ +E+K Q + K++ KE ++ L+ K+ I + E QK+ I L +
Sbjct: 872 KQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKL 931
Query: 505 DMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG 564
+ + L E +T K N + E V Q+A ++ E+ +
Sbjct: 932 SAKEDSIHILNEEYETKFK-----------NQEKKMEK-------VKQKAKEMQETLKKK 973
Query: 565 PLDVRLRKLAGEKEELLSQIRKLKLQLEEER-QKCSRNDGTVGDLAGLQNGSDLQFIEM- 622
LD + KL E E ++ + + Q + + N + D + + IE
Sbjct: 974 LLD-QEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESL 1032
Query: 623 ----QRDANRQISEYKFKLSKAEQDITTL--------EQSISRLEGQVLRYKTAAENAEK 670
+R+ N IS ++ KL++ +++ + EQ ++ L+ ++L + E K
Sbjct: 1033 TEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNK 1092
Query: 671 VEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKAN 713
LK E K L +++++ + LA+ K+KA+
Sbjct: 1093 EITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAH 1135
Score = 45.8 bits (107), Expect = 1e-04
Identities = 78/379 (20%), Positives = 158/379 (41%), Gaps = 41/379 (10%)
Query: 354 IQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDV----IEE 409
I D R KE ESL+EV + ++S + L Q + L+++ ++E
Sbjct: 1014 ISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE-----KKLNQQAEELQEIHEIQLQE 1068
Query: 410 QEEQMAE-------FYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRD--------- 453
+E+++AE F E EE +KE+ K + EL+E L+Q+
Sbjct: 1069 KEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQD 1128
Query: 454 --ELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREEL 511
+L ++++ ++ KE LQE L+ + K+ A E+ K ++ L ++ EE
Sbjct: 1129 ETKLKAHLEKLEVDLNKSLKENTFLQEQLV--ELKMLA-EEDKRKVSELTSKLKTTDEEF 1185
Query: 512 ADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLR 571
L+ + + K + D + E +A + + ++ +LE+ +++
Sbjct: 1186 QSLKSSHEKSNKS----LEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSS 1241
Query: 572 K---LAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANR 628
K + + K+K L + S + + L QN ++ F + A
Sbjct: 1242 KTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISF----QQATH 1297
Query: 629 QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRT 688
Q+ E + ++ + DI +L L+ + + AA E +LK E + +
Sbjct: 1298 QLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTL 1357
Query: 689 ALDKIEEMEMTNSHLAKRL 707
++++E ++ S L+K+L
Sbjct: 1358 MKEELKEKKVEISSLSKQL 1376
Score = 43.9 bits (102), Expect = 5e-04
Identities = 73/344 (21%), Positives = 145/344 (42%), Gaps = 70/344 (20%)
Query: 368 LKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKE 427
L+E L E +KY + + + + KNN I L++V ++ + K
Sbjct: 1797 LQEELEEKNKKYSLIVAQHVEKEGGKNN-IQAKQNLENVFDDVQ--------------KT 1841
Query: 428 LERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKI 487
L+ ++ C +L+ K++EL L ++ E+ R++ E L K +K+
Sbjct: 1842 LQEKELTCQILEQKIKELDSCLVRQKEV----HRVE-------------MEELTSKYEKL 1884
Query: 488 GALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAI 547
AL++ RN+ L EE T + + H ++ P N + H + +
Sbjct: 1885 QALQQMDG-----RNKPTELLEE-----NTEEKSKSH--LVQPKLLSNMEAQHNDLEFKL 1932
Query: 548 TVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGD 607
+E ++ + L LR L E ++ L ++K Q EE+ K + D
Sbjct: 1933 AGAEREKQKLGKEIVR--LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQED----- 1985
Query: 608 LAGLQNGSDLQFIEMQRDANRQISE--------YKFKLSKAEQDITTLEQSISRLEGQVL 659
L++ S L+ ++ R+ N Q+++ K ++KA++ L +S Q+L
Sbjct: 1986 -LELKHNSTLK--QLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLL 2042
Query: 660 R--------YKTAAENAEKVEDELKAEKRKLQRELRTALDKIEE 695
+ K A+ E++ D + E R+L+T L+++++
Sbjct: 2043 KKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQK 2086
Score = 40.4 bits (93), Expect = 0.006
Identities = 72/364 (19%), Positives = 150/364 (41%), Gaps = 46/364 (12%)
Query: 363 QGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENE 422
+G+K+ +L+E++E+ K Q N+L LK +E+ E + + +EN
Sbjct: 1100 EGVKQ-DTTLNELQEQLK-------QKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENT 1151
Query: 423 EKSKELERQKHMCSVLQHKMEELKEGLRQRDE----LIEEKQRMQQKIDTMTKEVFDLQE 478
++L K + + K+ EL L+ DE L ++ + ++ + E L E
Sbjct: 1152 FLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
Query: 479 TLLWK----DKKIGAL--EKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDG 532
L + KK AL K E I ++ + + ++ Q T K L+I
Sbjct: 1212 ELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRT-TKVKEALLI---- 1266
Query: 533 TPNGDVSHEPVAGAITVVSQEAAQVLESAGE-GPLDVRLRKLAGEKEELLSQIRKLKLQL 591
VS+ AQ+ + E L++ ++ + EE +QI+ +K +
Sbjct: 1267 -------------KTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADI 1313
Query: 592 EE---ERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLE 648
E E++ + G A + Q + + ++ K +L + + +I++L
Sbjct: 1314 ESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLS 1373
Query: 649 QSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLE 708
+ ++ L Q+ + +E E + + +++ E LD+++++ L+K E
Sbjct: 1374 KQLTDLNVQLQNSISLSEK----EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSK--E 1427
Query: 709 KMKA 712
K+ A
Sbjct: 1428 KISA 1431
>gi|30260188 Golgi autoantigen, golgin subfamily a, 5 [Homo sapiens]
Length = 731
Score = 73.2 bits (178), Expect = 8e-13
Identities = 128/598 (21%), Positives = 228/598 (38%), Gaps = 73/598 (12%)
Query: 141 SHKDLLSGLYFDQRNYSSLRHSKPTSAYYTRQSSSLYSDPLATYKSDRASPTANSGLLRS 200
S KD S +Y +Y+ L Y T P +TY S A N
Sbjct: 27 SRKDNASNIYSKNTDYTELHQQNTDLIYQT--------GPKSTYISSAADNIRNQKATIL 78
Query: 201 ASLASLYNGGLYNPYGPRTPSECSYYSSRISSARSSPGFTNDDTAS---------IVSSD 251
A A++ G RTP E S+ S R S F + + SS
Sbjct: 79 AGTANV-------KVGSRTPVEASHPVENASVPRPSSHFVRRKKSEPDDELLFDFLNSSQ 131
Query: 252 RASRGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDLSSLDEKS-DKQYAENYTRPSSR 310
+ GR E + + S VS V+ S+ + +++E S Q E + S
Sbjct: 132 KEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNP-SVTTIKTIEENSFGSQTHEAASNSDSS 190
Query: 311 NSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDI----YDLKDQIQDVE---GRYMQ 363
+ + SS D + + D EL ++ L++++Q + +Q
Sbjct: 191 HEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQ 250
Query: 364 GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 423
KE +E L++ + +K +++ D L QVD L + + ++ Q+A +E
Sbjct: 251 RSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQE 310
Query: 424 KSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWK 483
+ L + LQ + + + + + L Q + T + + + TL K
Sbjct: 311 ADQLLSTRTEALEALQSEKSRIMQDQSEGNSL------QNQALQTFQERLHEADATL--K 362
Query: 484 DKKIGALEKQKEYIACLRNERDMLREELAD---LQETVKTGEKHGLVIIPDGTPNGDVSH 540
++ + Q E+ A L N+ +M R+ LA+ L E + EK + + ++
Sbjct: 363 REQESYKQMQSEFAARL-NKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNL 421
Query: 541 EPVAGAITVVSQEAAQVLES-----------AGEGPLD------VRLRKLAGEKEELLSQ 583
E + Q+A ++L+S +G LD + L +L EKE +
Sbjct: 422 ESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREE 481
Query: 584 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQD 643
I+KL Q+ + R + + D+ Q E +D + QI+ K + E +
Sbjct: 482 IQKLMGQIHQLRSE-------LQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETE 534
Query: 644 ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQREL-RTALDKIEEMEMTN 700
+ L+Q +E + R K ++ K DE E +KL+ +L L + E+ N
Sbjct: 535 LERLKQEFHYIEEDLYRTKNTLQSRIKDRDE---EIQKLRNQLTNKTLSNSSQSELEN 589
Score = 33.9 bits (76), Expect = 0.54
Identities = 25/132 (18%), Positives = 61/132 (46%), Gaps = 2/132 (1%)
Query: 338 DTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESL-SEVEEKYKKAMVSNAQLDNEKNNL 396
D ++ + ++Q+QD+ + + G K K+ L +E+E ++ L KN L
Sbjct: 498 DMEAQQVNEAESAREQLQDLHDQ-IAGQKASKQELETELERLKQEFHYIEEDLYRTKNTL 556
Query: 397 IYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELI 456
++ + I++ Q+ N +S+ R + L K L+ +++ L+
Sbjct: 557 QSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLV 616
Query: 457 EEKQRMQQKIDT 468
+ +R++Q++++
Sbjct: 617 FQLERLEQQMNS 628
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 72.8 bits (177), Expect = 1e-12
Identities = 91/458 (19%), Positives = 204/458 (44%), Gaps = 79/458 (17%)
Query: 338 DTSLSEL-RDIYDLKDQIQDVEGRYMQGLKELKESLSEVE-----EKYKKAMVSNAQLDN 391
DT ++ L R+I DL+D+IQ ++ + ++ +E + ++E K+ K + QL
Sbjct: 384 DTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKID--QLKQ 441
Query: 392 EKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQ 451
E + ++ L+ +E Q ++ + E + L ++ ++LQ +++ L+ L +
Sbjct: 442 ELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEE 501
Query: 452 RDELIEEKQRMQQKID----TMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDML 507
++ + +K + Q + T+ E+ D+++ L K++KI L+K+ E + ++D
Sbjct: 502 KESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQ 561
Query: 508 REELADLQETVKTGEKH---GLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG 564
L D ++++T + L + + + E + +E + +ES +
Sbjct: 562 LTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKE 621
Query: 565 PLDVR-----LRKLAGEKEELL------------------SQIRKLKLQLEEERQKCSRN 601
D++ L+ EKE L S+++ L++ +E+++++CS+
Sbjct: 622 NKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKL 681
Query: 602 DGTVGDLAGLQNGSDL--QFIEMQRDANRQISEYKFKLSKAEQDITTL------------ 647
+ + +++ S + +F + + +++ S Y+ + KA+ ++ L
Sbjct: 682 EAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKN 741
Query: 648 --EQSISRLEGQVLRY-------------------KTAAENAEKV---EDELKAEKRKLQ 683
++ I+ LE LR+ K A+ E+V ED + + LQ
Sbjct: 742 DKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQ 801
Query: 684 -RELRTALDKI-EEMEMTNSHLAKRLEKMKANRTALLA 719
EL AL+K +E++ T + LA + + A + A LA
Sbjct: 802 IEELMNALEKTRQELDATKARLASTQQSL-AEKEAHLA 838
Score = 52.0 bits (123), Expect = 2e-06
Identities = 89/426 (20%), Positives = 173/426 (40%), Gaps = 64/426 (15%)
Query: 332 SSLIDPDTSLSELRDIYDLKDQIQDVE----GRYMQGLK-----ELKESLSEVEEKYKKA 382
S+++D L EL+ DL + D++ G M +K ELK+ +E+ +
Sbjct: 145 STMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARM 204
Query: 383 MVSNAQL---DNEKNNLIYQVDTLKD------------------------VIEEQEEQMA 415
V Q+ E +L + L+D IE EE
Sbjct: 205 SVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFR 264
Query: 416 EFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFD 475
E++ ++KEL + ++ ++E K+ L RDE I++ M Q +K + D
Sbjct: 265 RLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLED 324
Query: 476 LQETLLWKDKKIGALEKQKEYIACLRNERDM----LREEL---ADLQ-ETVKTGEKHGLV 527
E + +++ E Q ++ + ++++ LREEL + LQ E KT ++
Sbjct: 325 DNE----RTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVI 380
Query: 528 IIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELL-SQIRK 586
+ D +A + ++ G L+ R+ ++ E+ S +
Sbjct: 381 EMKD---------TKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKF 431
Query: 587 LKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR-DANRQISEYKFKLSKAEQDIT 645
+K ++++ +Q+ S+ + +L LQ + L+ + Q D + I K L+ EQ
Sbjct: 432 MKTKIDQLKQELSKKE---SELLALQ--TKLETLSNQNSDCKQHIEVLKESLTAKEQRAA 486
Query: 646 TLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAK 705
L+ + L ++ ++ K +L EK L E+R D +E E + L K
Sbjct: 487 ILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQK 546
Query: 706 RLEKMK 711
++E ++
Sbjct: 547 KIENLQ 552
Score = 35.0 bits (79), Expect = 0.24
Identities = 34/182 (18%), Positives = 91/182 (50%), Gaps = 15/182 (8%)
Query: 342 SELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVD 401
++L+ ++++D + + + +K+L + S ++ KA E + L+ +
Sbjct: 683 AQLKKAHNIEDDSR-MNPEFADQIKQLDKEASYYRDECGKAQA-------EVDRLLEILK 734
Query: 402 TLKDVIEEQEEQMAEF----YRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR-DELI 456
+++ ++++++AE R ++++K++ KH + + K +L E +R+R D +
Sbjct: 735 EVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMA 794
Query: 457 EEKQRMQ--QKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADL 514
+ Q +Q + ++ + K +L T +L +++ ++A LR ER EE+ ++
Sbjct: 795 DNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEM 854
Query: 515 QE 516
++
Sbjct: 855 KQ 856
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 72.4 bits (176), Expect = 1e-12
Identities = 102/428 (23%), Positives = 196/428 (45%), Gaps = 87/428 (20%)
Query: 338 DTSLSELRD-IYDLKDQIQDVEGRYMQGLKELKESLSEVEEK----YKKAMVSNAQLDNE 392
DT L L+ + L +Q D + Q ++ LKESL+ E++ + +L+ +
Sbjct: 451 DTELLALQTKLETLTNQFSDSK----QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK 506
Query: 393 KNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 452
+ L + ++D+ EE+ Q E + + L+ ++ +VLQ K+E L+E LR +
Sbjct: 507 ETMLNKKTKQIQDMAEEKGTQAGEIH----DLKDMLDVKERKVNVLQKKIENLQEQLRDK 562
Query: 453 DE----LIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLR 508
++ L E + +Q + L+E L K++ I L++Q++ R+ER+ +
Sbjct: 563 EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD-----RDEREK-Q 616
Query: 509 EELADLQETVK-TGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLD 567
EE+ + ++ +K EK L+ GD+S + A + +E A L S+G
Sbjct: 617 EEIDNYKKDLKDLKEKVSLL-------QGDLSEKE---ASLLDLKEHASSLASSG----- 661
Query: 568 VRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTV--GDLAGLQNGSDLQFIEMQRD 625
L+K S+++ L++ LE+++++C + + + A L+ + + + +
Sbjct: 662 --LKK--------DSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQH 711
Query: 626 ANRQISEYKFKLSKAEQDITTL--------------EQSISRLEGQV---------LRYK 662
R+I+ YK + SKA+ ++ L ++ I+ LE QV L++K
Sbjct: 712 LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK 771
Query: 663 TAA---------ENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKAN 713
E A + ED L ++LQ LR D+IEE+E + ++ A
Sbjct: 772 EQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELE----EALRESVQITAE 827
Query: 714 RTALLAQQ 721
R +LAQ+
Sbjct: 828 REMVLAQE 835
Score = 51.6 bits (122), Expect = 3e-06
Identities = 73/344 (21%), Positives = 144/344 (41%), Gaps = 30/344 (8%)
Query: 381 KAMVSNAQLDNEKNNLIYQVDTLKD----VIEEQEEQMAEFYRENEEKSKELERQKHMCS 436
+A+ ++ + N L Q + + V E EE + E+E ++KEL +
Sbjct: 230 QALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLE 289
Query: 437 VLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEY 496
++ ++E K+ L RDE I++ M Q K + E + +++ E +
Sbjct: 290 EMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHE----RTRRLAEAEMHVHH 345
Query: 497 IACL----RNERDMLREEL----ADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAIT 548
+ L E MLREE+ + ++ KT ++ + D + S E +
Sbjct: 346 LESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS---SMERGLRDL- 401
Query: 549 VVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDL 608
+E Q+L+S G + R ++ + E S + +K ++ + +Q+ SR D +L
Sbjct: 402 ---EEEIQMLKSNGALSTEEREEEMK-QMEVYRSHSKFMKNKIGQVKQELSRKD---TEL 454
Query: 609 AGLQNGSDLQFIEMQ-RDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAEN 667
LQ + L+ + Q D+ + I K L+ EQ L+ + L ++ +T
Sbjct: 455 LALQ--TKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK 512
Query: 668 AEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 711
K ++ EK E+ D ++ E + L K++E ++
Sbjct: 513 KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQ 556
Score = 48.1 bits (113), Expect = 3e-05
Identities = 73/394 (18%), Positives = 165/394 (41%), Gaps = 66/394 (16%)
Query: 343 ELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDT 402
E R ++ D+IQ +E + + K+ S+ + + + + +++NEKN
Sbjct: 698 EARASPEMSDRIQHLE----REITRYKDESSKAQAEVDRLLEILKEVENEKN-------- 745
Query: 403 LKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEE-LKEGLRQRDELIEEKQR 461
++++++AE R+ ++++K++ KH V + K + L+E R+ D L + Q+
Sbjct: 746 ------DKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQ 799
Query: 462 MQQKIDTMTKEVFDLQE--------------TLLWKDKKIGALEKQKEYIAC----LRNE 503
+Q + + +L+E L ++ EKQ E + ++ E
Sbjct: 800 LQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQE 859
Query: 504 RDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGE 563
+ ++ +L+ Q+++ E H N + + QEA +L + E
Sbjct: 860 LESMKAKLSSTQQSLAEKETH--------LTNLRAERRKHLEEVLEMKQEA--LLAAISE 909
Query: 564 GPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQ 623
++ L +L+ K++ ++ LK + + Q+ + L N D F
Sbjct: 910 KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMA-DNYEDDHF---- 964
Query: 624 RDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAE-------------K 670
+ ++ + +K + Q + L+Q+ S+L+ + T + +
Sbjct: 965 KSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYN 1024
Query: 671 VEDELKAEKRKLQRELRTAL-DKIEEMEMTNSHL 703
++D+ A + +LQ+ R L D++E+ E N+ L
Sbjct: 1025 LDDDQAAWENELQKMTRGQLQDELEKGERDNAEL 1058
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 72.4 bits (176), Expect = 1e-12
Identities = 80/382 (20%), Positives = 177/382 (46%), Gaps = 41/382 (10%)
Query: 350 LKDQIQDVEGRYMQ---GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDV 406
L++++Q VE + +KELK L K ++ QL E ++L ++ ++
Sbjct: 214 LQEKLQLVESEKSEIQLNVKELKRKLERA-----KLLLPQQQLQAEADHLGKELQSVSAK 268
Query: 407 IEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKI 466
++ Q E+ + R N+++ +++ RQ+ + K++E +E +R++ EEK R Q+++
Sbjct: 269 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQ----EEKMRRQEEM 324
Query: 467 DTMTKEVFDLQETLLW-KDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHG 525
+E QE ++W K++KI LE++ +R E++ R+E ++E K E+
Sbjct: 325 MWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR-EQEEKRQEEEKIREQEKRQEQEA 383
Query: 526 LVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIR 585
+ + E + + ++ + E E + + K+ ++EE+ Q
Sbjct: 384 KMWRQE---------EKIREQEEKIREQEEMMQEQ--EEKMGEQEEKMWEQEEEMQEQEE 432
Query: 586 KLKLQLEE--ERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQD 643
K++ Q E+ E++K R Q + EM ++ ++ E + K+ + E
Sbjct: 433 KMRRQEEKIREQEKKIRE----------QEEKIREQEEMMQEQEEKMGEQEGKMCEQEAK 482
Query: 644 ITTLEQSISRLEGQVLRY-KTAAENAEKV---EDELKAEKRKLQRELRTALDKIEEMEMT 699
+ E+ + R E ++ K E EK+ E+ ++ ++ K+ + ++ E+M+
Sbjct: 483 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 542
Query: 700 NSHLAKRLEKMKANRTALLAQQ 721
+ ++ EKM+ L Q+
Sbjct: 543 EEKMRRQEEKMREQEVRLRQQE 564
Score = 38.9 bits (89), Expect = 0.017
Identities = 23/116 (19%), Positives = 60/116 (51%)
Query: 343 ELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDT 402
++R+ ++ + ++ G + E + + E EEK ++ + + + ++
Sbjct: 454 KIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 513
Query: 403 LKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEE 458
+++++EQEE+M E + E+ ++++ Q+ + KM E + LRQ++E ++E
Sbjct: 514 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 69.7 bits (169), Expect = 9e-12
Identities = 89/401 (22%), Positives = 173/401 (43%), Gaps = 55/401 (13%)
Query: 363 QGLKELKESLSEVEEKYKKAMVSNAQLDNEKN-------NLIYQVDTLKDVIEEQEEQMA 415
+ ++LKE LSEVE KY+ QL ++ L +++ L + E E Q+
Sbjct: 372 EATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLG 431
Query: 416 EFYRENEEK----SKELERQKHMCSVLQHKMEELKEGLRQR--------------DELIE 457
E + +E+ S++L ++ + LQ K+ L+E L+++ + +
Sbjct: 432 EAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQ 491
Query: 458 EKQRMQQKIDTMTKEV-FDLQETLLW---KDKKI----GALEKQKEYIACLRNERDMLRE 509
E+Q +QQ +E DL++ L KD+KI L+K KE I+ L ER+ L
Sbjct: 492 EQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYA 551
Query: 510 E----------LADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLE 559
+ L LQE T ++ + + + N SH+ + QE L
Sbjct: 552 KIQAGEGETAVLNQLQEKNHTLQEQ-VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLR 610
Query: 560 SAGEG--PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQ-KCSRNDGTVGDLAGLQNGSD 616
+A + L+ + +L + E ++ +L +Q++ + + S A LQN D
Sbjct: 611 AAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLD 670
Query: 617 LQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELK 676
+Q D +++++ +L + + ++ S+LE + YK + E+ +EL+
Sbjct: 671 TAQNALQ-DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELE 729
Query: 677 AEKRKLQRE-------LRTALDKIEEMEMTNSHLAKRLEKM 710
+ +KL+ + AL +++ N+ L R ++
Sbjct: 730 GQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATEL 770
Score = 62.8 bits (151), Expect = 1e-09
Identities = 81/376 (21%), Positives = 164/376 (43%), Gaps = 53/376 (14%)
Query: 363 QGLKELKESLSEVEEKYK------KAMVSNAQLDNEK--NNLIYQVDTLKDVIEEQEEQM 414
+ L+ +K+ L++ EE+ + + + ++ +E+ N + V L+ V E+E M
Sbjct: 793 EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM 852
Query: 415 AEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEE-KQRMQQKIDTMTKEV 473
E ++ SK + K+ S + + ++ K + ++ +E K ++Q +++ KE
Sbjct: 853 TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQ 912
Query: 474 FDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGT 533
+L+++L EK+KE L+ E + ++E+L Q T+K EK
Sbjct: 913 KELKKSL----------EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE--------- 953
Query: 534 PNGDVSHEPVAGAITVVSQEAAQVLES--AGEGPLDVRLRKLAGEKEELLSQIRKLKLQL 591
+ + G I + Q + Q + A +G L + + + + +L Q+ + +L
Sbjct: 954 ------EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007
Query: 592 EEERQKCS--RNDGTVGDLAGLQNGSDLQFIEMQRDANRQ-ISEYKFKLSKAEQDITTLE 648
E++K S +N+ Q SD E + A RQ + + KLS A++D+ +
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067
Query: 649 QSISRLEGQVLRYKTA--------AENAEKVEDELKA------EKRKLQRELRTALDKIE 694
I + KTA A+ +++++ KA EK ++EL K+
Sbjct: 1068 NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLA 1127
Query: 695 EMEMTNSHLAKRLEKM 710
E+E K + K+
Sbjct: 1128 EIEEIKCRQEKEITKL 1143
Score = 58.5 bits (140), Expect = 2e-08
Identities = 83/470 (17%), Positives = 187/470 (39%), Gaps = 51/470 (10%)
Query: 285 SIPDLSSLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSEL 344
++ D +L+ + + + ++ + AS+ +S S G + + EL
Sbjct: 235 TLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAV----YVQEL 290
Query: 345 RDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK 404
+ + +++ + L + ++ +++EEK+ + VS + + L+
Sbjct: 291 QKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ 350
Query: 405 DVIEEQEEQMAEFYRENEEKSKELERQKHMCSVL----QHKMEELKEGLRQRDELIEEKQ 460
+ E + + E EK + ++ K S + QH E K+ +QR+E +
Sbjct: 351 SRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGL 410
Query: 461 RMQQKIDTMTKEVFDLQETL------LWKDKKIGA--LEKQKEYIACLRNERDMLREELA 512
++Q +I+ + ++ + + L L + +++ + L +++ +A L+ + L E+L
Sbjct: 411 QLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLK 470
Query: 513 DLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGE--GPLDVRL 570
+ + T T +H L D T + + + T +EA LE G D ++
Sbjct: 471 E-KVTNSTELQHQL----DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI 525
Query: 571 RKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQ-----------------N 613
+ L ++ I L+ + E+ K +G L LQ
Sbjct: 526 QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLK 585
Query: 614 GSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQV-----------LRYK 662
+ Q + + Q+ E K L A+ + +LE S++ L Q+ ++ K
Sbjct: 586 NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645
Query: 663 TAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 712
E E A++ LQ L TA + +++ + + + +L+++ A
Sbjct: 646 AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA 695
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/355 (18%), Positives = 156/355 (43%), Gaps = 27/355 (7%)
Query: 365 LKELKESLSE----VEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRE 420
L E KE +S+ ++ K + + + A ++ +L +DT ++ ++++++++ + +
Sbjct: 630 LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689
Query: 421 NEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEV------- 473
++ + +L+ ++ CS L+ ++E KE ++ EE + +K++ + EV
Sbjct: 690 LDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 749
Query: 474 -FDL-QETLLWKDKKIGA------LEKQKEYIACLRNERDMLREELADLQETVKTGEKHG 525
DL Q+ L D ++ A LE +KE ++ R + E L +++ + E+
Sbjct: 750 LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809
Query: 526 LVIIPDG---TPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLS 582
++ D + + HE + I E +V + L L + + ++
Sbjct: 810 QILKQDFETLSQETKIQHEELNNRIQTTVTELQKV--KMEKEALMTELSTVKDKLSKVSD 867
Query: 583 QIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQ 642
++ K + E+E QK + DL Q + ++ E K L K ++
Sbjct: 868 SLKNSKSEFEKENQK---GKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKE 924
Query: 643 DITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEME 697
L+ ++ ++ Q+++ + + EK E +L+ +L++ +IE ++
Sbjct: 925 ASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQ 979
Score = 57.0 bits (136), Expect = 6e-08
Identities = 78/422 (18%), Positives = 181/422 (42%), Gaps = 55/422 (13%)
Query: 339 TSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNN--L 396
T+++EL+ + K+ + M L +K+ LS+V + K + S + +N+K +
Sbjct: 836 TTVTELQKVKMEKEAL-------MTELSTVKDKLSKVSDSLKNSK-SEFEKENQKGKAAI 887
Query: 397 IYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELI 456
+ T K++ + + QM +E +E K LE++K L+ ++ ++E L Q +
Sbjct: 888 LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947
Query: 457 EEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNE-RDMLREELADLQ 515
++ ++ +Q++ E L+++ K K+I AL+ + + + E + L+++L
Sbjct: 948 KQNEKEEQQLQGNINE---LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAA 1004
Query: 516 ETVKTGEKHGLVIIPDGTPNGDVSHEPVAG-------AITVVSQEAAQVLESAGEGPLD- 567
+ + EK + ++ + + + + + Q+ V E D
Sbjct: 1005 QEL-AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDL 1063
Query: 568 VRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRN-DGTVGDLAGLQNGSDLQFIEMQRDA 626
+ R G + +L+ +++ K LE++ K + L +Q L+ E+ +
Sbjct: 1064 ISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEK 1123
Query: 627 NRQISEYKFKLSKAEQDITTLEQSIS-------------------------RLEGQVLRY 661
++ ++E + + E++IT L + + L+G+
Sbjct: 1124 SK-LAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSL 1182
Query: 662 KTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKR---LEKMKANRTALL 718
K A E ++ + LK + +K + EL+ + IE+ +S + ++ ++K + N L
Sbjct: 1183 KAAVEQEKRNQQILKDQVKKEEEELKK--EFIEKEAKLHSEIKEKEVGMKKHEENEAKLT 1240
Query: 719 AQ 720
Q
Sbjct: 1241 MQ 1242
Score = 51.6 bits (122), Expect = 3e-06
Identities = 82/421 (19%), Positives = 170/421 (40%), Gaps = 74/421 (17%)
Query: 338 DTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLI 397
D ++L+D + Q++ Y + L++ E+E + KK + ++ K +
Sbjct: 691 DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL 750
Query: 398 YQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSV----LQHK---MEELKEGLR 450
+++Q + + E SK+LE +K + S LQ K +E +K+ L
Sbjct: 751 QD-------LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLT 803
Query: 451 QRDELIEEKQRMQQKIDTMTKE---------------VFDLQETLLWKDKKIGALEKQKE 495
+++ EEKQ ++Q +T+++E V +LQ+ + K+ + L K+
Sbjct: 804 KQE---EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD 860
Query: 496 YIA----CLRNERDMLREE-------LADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVA 544
++ L+N + +E + DL++T K KH L + + T +
Sbjct: 861 KLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKE-LKHQLQVQMENTLKEQKELKKSL 919
Query: 545 GAITVVSQEAAQVLESAGEGPLDVR--LRKLAGEKEELLSQIRKLKLQLEEERQKCSRND 602
S + L S E + + L++ E+++L I +LK E+++++
Sbjct: 920 EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQ 979
Query: 603 G----TVGDLAGLQNGSDLQFIEMQRDA------------NRQISEYKFK---------- 636
G V L+N Q + ++ N + S+ FK
Sbjct: 980 GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE 1039
Query: 637 --LSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIE 694
L QD+ ++E+ +S + ++ + N K+ ELK K L+++ +++
Sbjct: 1040 SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ 1099
Query: 695 E 695
E
Sbjct: 1100 E 1100
Score = 43.9 bits (102), Expect = 5e-04
Identities = 66/338 (19%), Positives = 141/338 (41%), Gaps = 50/338 (14%)
Query: 349 DLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIE 408
+L++++Q + Q L KE +S ++ Y+K+ + QL ++ ++ + ++
Sbjct: 991 ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050
Query: 409 EQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDT 468
EE+++ + ++ Q + ++ELK + L ++ + +Q++
Sbjct: 1051 SVEEKLSLAQEDLISNRNQIGNQNKL-------IQELKTA---KATLEQDSAKKEQQLQE 1100
Query: 469 MTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVI 528
K + D+Q+ K+K+ L +K +A + + +E+ L E +K+ H L
Sbjct: 1101 RCKALQDIQKEKSLKEKE---LVNEKSKLAEIEEIKCRQEKEITKLNEELKS---HKLES 1154
Query: 529 IPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLK 588
I + T D + Q LE G+ K A E+E+ QI K +
Sbjct: 1155 IKEITNLKDAKQLLI-----------QQKLELQGKAD----SLKAAVEQEKRNQQILKDQ 1199
Query: 589 LQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLE 648
++ EEE K +FIE + + +I E + + K E++ L
Sbjct: 1200 VKKEEEELK-------------------KEFIEKEAKLHSEIKEKEVGMKKHEENEAKLT 1240
Query: 649 QSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQREL 686
I+ L + K +++++ EL+ + L+ E+
Sbjct: 1241 MQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEI 1278
Score = 35.4 bits (80), Expect = 0.19
Identities = 44/233 (18%), Positives = 106/233 (45%), Gaps = 16/233 (6%)
Query: 497 IACLRNERDMLREELADLQETVKTGEKHGLVIIPD-----GTPNGDVSHEPVAGAITVVS 551
+A R++ +LR+E+ DLQ ++K + + + + G + + + +
Sbjct: 78 LALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAEL 137
Query: 552 QEAAQVLESAGEGPLDVRLRKLAGEKE--ELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 609
Q Q LE A +++ K E++ +L ++I +K + +EER + V L
Sbjct: 138 QSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLT 197
Query: 610 GLQNG-----SDLQFIEMQRDANRQISEYKFKLSKAE--QDITTL--EQSISRLEGQVLR 660
N DL+ +QR ++ K +L + + D TL E+ +L+ + +
Sbjct: 198 EELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKK 257
Query: 661 YKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKAN 713
++ ++E +L++E K +E+ + ++++++ + + L ++ + + N
Sbjct: 258 LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN 310
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 69.3 bits (168), Expect = 1e-11
Identities = 98/426 (23%), Positives = 182/426 (42%), Gaps = 71/426 (16%)
Query: 304 YTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSE-LRDIYDLKDQIQDVEGRYM 362
+ R + + SA L N G+ S LSE L++ + K+Q++ R
Sbjct: 882 HARKEEKEAVSARRALE-NELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLR----RLK 936
Query: 363 QGLKELKESLSEVEEKYKKAMVSNAQLDNEKN-NLIYQVDTLKDVIEEQEEQMAEFYREN 421
++ + L + EK +K M + L Q+D K E+ ++AE R+
Sbjct: 937 NEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYK---EKNRRELAEMQRQL 993
Query: 422 EEKSKELERQKHMCSVLQHKM----EELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQ 477
+EK+ E E+ + +Q +M EEL++ R +DE + ++Q ++Q + + ++L+
Sbjct: 994 KEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLE---YELE 1050
Query: 478 ETLLWKDKKIGALEKQKEYIACL-------RNERDMLREELADLQETVKTGEKHGLVIIP 530
KD + +++ ++ ++ L RN D+L E ++ +E ++ ++
Sbjct: 1051 AKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNE---LLQ 1107
Query: 531 DGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGE----KEELLSQIRK 586
+ D+ + ++ LE + L R+ L G KE L+ Q+
Sbjct: 1108 ERAARQDLECDKIS-------------LERQNKD-LKSRIIHLEGSYRSSKEGLVVQMEA 1153
Query: 587 LKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITT 646
+LE+ + R D A LQ + R R++ E ++ +T
Sbjct: 1154 RIAELEDRLESEER------DRANLQLSN--------RRLERKVKELVMQVDDEHLSLTD 1199
Query: 647 LEQSIS-RLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAK 705
+ +S RL+ K E AE+ D L++ K+KLQREL E+M+M N HL
Sbjct: 1200 QKDQLSLRLKAM----KRQVEEAEEEIDRLESSKKKLQRELE------EQMDM-NEHLQG 1248
Query: 706 RLEKMK 711
+L MK
Sbjct: 1249 QLNSMK 1254
Score = 59.7 bits (143), Expect = 9e-09
Identities = 87/438 (19%), Positives = 180/438 (41%), Gaps = 56/438 (12%)
Query: 305 TRPSSRNSASATTPLSGNS--SRRGSGDTSSLI--------DPDTSLSELRDIYDLKDQI 354
T PS+ N+ + L G +++ + +T+ I D + R + + ++I
Sbjct: 526 TFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKI 585
Query: 355 QDVEGRYM---QGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQE 411
Q ++ R QG + S SEV++ ++ ++ + L +V +++ EE+E
Sbjct: 586 QTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERE 645
Query: 412 EQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR-DELIEEKQRMQQKIDTMT 470
A + ++++E S LQ ++EE + LR+ +EL + K +Q
Sbjct: 646 RMRANLEELRSQHNEKVEEN----STLQQRLEESEGELRKNLEELFQVKMEREQH----Q 697
Query: 471 KEVFDLQETLL-WKDKKIGALEKQKEYIACLRNERDMLREELADL------QETVKTGEK 523
E+ DLQ+ L D+ A + L E +++L DL QE + +
Sbjct: 698 TEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRE 757
Query: 524 HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVL-ESAGEGPLDVRL---RKLAGEKEE 579
L + SH+ + Q L ES E +V + R E+++
Sbjct: 758 RELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQ 817
Query: 580 LLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSK 639
+++R LQ E E+ LQ S+ + R++++ + ++
Sbjct: 818 AGTEMRVKLLQEENEK---------------LQGRSE--------ELERRVAQLQRQIED 854
Query: 640 AEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMT 699
+ D ++++ + EG++ + + A +A K E E + +R L+ EL A + +
Sbjct: 855 LKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQE 914
Query: 700 NSHLAKRLEKMKANRTAL 717
L+++L++ + L
Sbjct: 915 QKQLSEKLKEESEQKEQL 932
Score = 47.4 bits (111), Expect = 5e-05
Identities = 76/400 (19%), Positives = 170/400 (42%), Gaps = 81/400 (20%)
Query: 338 DTSLSELRDIYDLKDQIQDVEGRYMQGLKEL-----KESLSEVEEKYKKAMVSNAQLDNE 392
D + +L++ YD ++Q + + K + + + SE ++ + V Q +NE
Sbjct: 775 DQEMDKLKEQYDA--ELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENE 832
Query: 393 KNNLIYQVDTLKDVIEEQEEQMAEFYRE------NEEKSKELERQ-----KHMCSVLQHK 441
K L+ EE E ++A+ R+ +E K+KE ++ + + L H
Sbjct: 833 K---------LQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHA 883
Query: 442 MEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLR 501
+E KE + R L E + Q + T+E L E K+ +QKE + L+
Sbjct: 884 RKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSE-------KLKEESEQKEQLRRLK 936
Query: 502 NERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESA 561
NE + R L KT EK + +E A ++E++
Sbjct: 937 NEMENERWHLG------KTIEK--------------------------LQKEMADIVEAS 964
Query: 562 GEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIE 621
L+++ +L KE+ ++ +++ QL+E+ + ++ L ++ +++ +E
Sbjct: 965 RTSTLELQ-NQLDEYKEKNRRELAEMQRQLKEKTLEAEKS-----RLTAMKMQDEMRLME 1018
Query: 622 MQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK 681
++ +Y+ +A LEQ++ LE ++ ++ ++ +++ + +
Sbjct: 1019 ------EELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQ 1072
Query: 682 LQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 721
L+ EL ++ ++ + +++ E+M+ R LL ++
Sbjct: 1073 LEMELE---EERNNSDLLSERISRSREQMEQLRNELLQER 1109
Score = 43.1 bits (100), Expect = 9e-04
Identities = 33/131 (25%), Positives = 54/131 (41%), Gaps = 29/131 (22%)
Query: 349 DLKDQIQDVEGRYMQG-----------LKELKESLSEVEEKYKKAMVSNAQLDNEKNNLI 397
DLK +I +EG Y + EL++ L E +SN +L+ + L+
Sbjct: 1128 DLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELV 1187
Query: 398 YQVD------------------TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQ 439
QVD +K +EE EE++ ++ +ELE Q M LQ
Sbjct: 1188 MQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQ 1247
Query: 440 HKMEELKEGLR 450
++ +K+ LR
Sbjct: 1248 GQLNSMKKDLR 1258
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 69.3 bits (168), Expect = 1e-11
Identities = 105/497 (21%), Positives = 205/497 (41%), Gaps = 81/497 (16%)
Query: 246 SIVSSDRASRGRRESVVSAADYFSRSNRRGSVVSEVDDIS--IPDLSSLDEKSDKQYAEN 303
+++SS+ + + E V +Y + S + S++SE D +S + DL E + + A
Sbjct: 1716 TLLSSNASMKEELERV--KMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANL 1773
Query: 304 YTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKD---------QI 354
N + T G S G + + T + + K
Sbjct: 1774 EATEKHDNQTNVTE--EGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSS 1831
Query: 355 QDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQM 414
D Y+Q + +LKE ++ +EE+ +K + L+NEKN L+ Q+ T ++ +E++
Sbjct: 1832 HDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEV 1891
Query: 415 AEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVF 474
+ N++ +EL R + L+ EE K+ L +R L+ + + I ++V
Sbjct: 1892 TKMNLLNQQIQEELSR----VTKLKETAEEEKDDLEER--LMNQLAELNGSIGNYCQDVT 1945
Query: 475 DLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTP 534
D Q ++NE +L E+ +L++ V E+ ++ + T
Sbjct: 1946 DAQ----------------------IKNE--LLESEMKNLKKCVSELEEEKQQLVKEKT- 1980
Query: 535 NGDVSHEPVAGAITVVSQEAAQVLESAGEGPLD----VRLRKLAGEKEELLSQIRKLKLQ 590
V E + +E + ++ A + P + L++L EK++ + Q++K ++
Sbjct: 1981 --KVESE--------IRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIR 2030
Query: 591 LEEERQKCSRNDGTVGDLAGLQNGSD----------LQFIEMQRDANRQISEYKFKLSKA 640
+E K S + TV L +Q S Q +E ++ A +++ +K L
Sbjct: 2031 YQE---KISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDT 2087
Query: 641 EQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDK--IEEMEM 698
+ + + +L+ K N E V+ ++K + L+R L A +K E+ M
Sbjct: 2088 QSEAARVLADNLKLK------KELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNM 2141
Query: 699 TNSHLAKRLEKMKANRT 715
A R EK+ T
Sbjct: 2142 QEKLDALRREKVHLEET 2158
Score = 63.5 bits (153), Expect = 6e-10
Identities = 95/435 (21%), Positives = 176/435 (40%), Gaps = 81/435 (18%)
Query: 350 LKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEE 409
L +I+ ++ + E +E E++++Y+ + S + NE + + V + + +
Sbjct: 1586 LVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVV----EAVRQ 1641
Query: 410 QEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRD--------ELIEEKQR 461
+++++ R E KE E+Q + +MEE+KE +R+ EL EE R
Sbjct: 1642 EKQELYGKLRSTEANKKETEKQ---LQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDR 1698
Query: 462 MQQKIDTMTKEVFDLQETLLWKDKKI-GALEKQK-EY------IACLRNERDMLREELAD 513
++ ++ + ETLL + + LE+ K EY L +E+D L EE+ D
Sbjct: 1699 LRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQD 1758
Query: 514 L----------QETVKTGEKH---------GLVIIPDGTPNGD----------------- 537
L Q ++ EKH G IP T D
Sbjct: 1759 LKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSA 1818
Query: 538 -----------VSHEPVAGAITVVSQEAAQVLESAGEGPLDVRL-RKLAGEKEELLSQIR 585
SH+ + + + Q ++ E + + L EK LLSQI
Sbjct: 1819 KSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIS 1878
Query: 586 ----KLKLQLEEERQKCSRNDGTVGDLA---GLQNGSDLQFIEMQRDANRQISEYKFKLS 638
+LK+ EE + N +L+ L+ ++ + +++ Q++E +
Sbjct: 1879 TKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIG 1938
Query: 639 KAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTA-LDKIE--E 695
QD+T + LE ++ K E+ + +L EK K++ E+R L+KI+ +
Sbjct: 1939 NYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQ 1998
Query: 696 MEMTNSHLAKRLEKM 710
E N AK L+++
Sbjct: 1999 KEPGNKSHAKELQEL 2013
Score = 63.2 bits (152), Expect = 8e-10
Identities = 82/394 (20%), Positives = 178/394 (45%), Gaps = 68/394 (17%)
Query: 354 IQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQ 413
++ V+ + L+ KE+L++ E KKA A + K ++++ + +
Sbjct: 2045 LEFVQTESQKDLEITKENLAQAVEHRKKAQAELA--------------SFKVLLDDTQSE 2090
Query: 414 MAEFYRENEEKSKELERQKHMC-SVLQHKMEELKEGLRQRDEL-IEEKQRMQQKIDTMTK 471
A +N + KEL+ K S ++ K E+L+ L Q +E ++EK+ MQ+K+D + +
Sbjct: 2091 AARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRR 2150
Query: 472 E-------VFDLQETLLWKDKKIGALEKQ-----------KEYIACLRNERDMLREE--- 510
E + ++Q TL KDK++ L++ + ++ L+++RD + +E
Sbjct: 2151 EKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKK 2210
Query: 511 --------LADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAG 562
+ +E ++ E + ++ D + E + I+ + + Q+ ES
Sbjct: 2211 WERKFSDAIQSKEEEIRLKEDN-CSVLKDQLRQMSIHMEELKINISRLEHD-KQIWESKA 2268
Query: 563 EGPLDVRLR---KLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTV----GDLAGLQNG- 614
+ + ++ + L GE +ELLSQ+ + + + + ++ + + L L N
Sbjct: 2269 QTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSL 2328
Query: 615 -------SDLQFIEMQRDANRQISEYKFK-----LSKAEQDITTLEQSISRLEGQVLRYK 662
+L+ I Q++A+ Q S++ ++ L + + + L + I+ E +++
Sbjct: 2329 EKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLL 2388
Query: 663 TAAENAEKVE-DELKAEKRKLQRELRTALDKIEE 695
+ E A +V EL+ + K +EL L + EE
Sbjct: 2389 SGKEEAIQVAIAELRQQHDKEIKELENLLSQEEE 2422
Score = 60.8 bits (146), Expect = 4e-09
Identities = 128/580 (22%), Positives = 233/580 (40%), Gaps = 117/580 (20%)
Query: 234 RSSPGFTND-DTASIVSSDRASRGRRESVVSAADY-------FSRSNRRGSVVSEVDDIS 285
+S PG T + D+ S+ + S ESV SA FS + + + ++D +
Sbjct: 1791 QSIPGETEEQDSLSMSTRPTCS----ESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLK 1846
Query: 286 IPDLSSLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLS--- 342
++ L+E+ K + T + +N T LS S++ G+ L + T ++
Sbjct: 1847 -ERIAGLEEEKQKNKEFSQTLENEKN-----TLLSQISTK--DGELKMLQEEVTKMNLLN 1898
Query: 343 -----ELRDIYDLKDQIQ----DVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEK 393
EL + LK+ + D+E R M L EL S+ + A + N L++E
Sbjct: 1899 QQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEM 1958
Query: 394 NNLIYQVDTLKD----VIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGL 449
NL V L++ +++E+ + +E +E EK + +++ S + E LKE
Sbjct: 1959 KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQ 2018
Query: 450 RQRDELIEEKQRMQQKIDTMTKEVFDLQ--ETLLWKDKKIGALEKQKEYIACLRNERDML 507
++ +L ++ R Q+KI + + V L+ +T KD LE KE +A R
Sbjct: 2019 QEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKD-----LEITKENLAQAVEHRKKA 2073
Query: 508 REELADLQETVKTGEKHGLVIIPDGTP---NGDVSHEPVAGAITVVSQEAAQVLESAGEG 564
+ ELA + + + ++ D + E V + ++ + LE A E
Sbjct: 2074 QAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEK 2133
Query: 565 PLDVR---------LRKLAGEKEELLSQIRKLKLQLEEERQKCSRN-DGTVGDLAGLQNG 614
L + LR+ EE + +I+ + ++E Q+ N D TV LA
Sbjct: 2134 HLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKS 2193
Query: 615 SDLQFIEMQRDANRQISEYKF---KLSKA----EQDITTLEQSISRLEGQVLRY------ 661
+Q D +R I E K K S A E++I E + S L+ Q+ +
Sbjct: 2194 MS----SLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEE 2249
Query: 662 -------------------KTAAENAEKVEDELKAEKR---------------------K 681
+T + +KV D L+ E + K
Sbjct: 2250 LKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAK 2309
Query: 682 LQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 721
L+ EL++ D++ ++ S+ ++ ++ K N ++ QQ
Sbjct: 2310 LESELKSLKDQLTDL----SNSLEKCKEQKGNLEGIIRQQ 2345
Score = 59.7 bits (143), Expect = 9e-09
Identities = 90/412 (21%), Positives = 182/412 (44%), Gaps = 64/412 (15%)
Query: 347 IYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQ---VDTL 403
I L+ Q+Q+ E ++G + ++ S+VEE + ++ L+ + V+TL
Sbjct: 833 IRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETL 892
Query: 404 KDVIEEQEEQMAEFYRENEEKSKELERQKHMCSV----LQHKMEELKEGLRQRDELIEEK 459
+ IEE+++Q+ E EK +L +K V L+ ++ L + E +EE
Sbjct: 893 QQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEED 952
Query: 460 QR----MQQKIDTM------TKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLR- 508
++Q D M +KE + LL K+ + +++++ A L N +++L+
Sbjct: 953 NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENE----QRKRKLQAALINRKELLQR 1008
Query: 509 -----EELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGE 563
EELA+L++ K I T G+V + ++E ++ ++
Sbjct: 1009 VSRLEEELANLKDESKK------EIPLSETERGEVEEDK-------ENKEYSEKCVTSKC 1055
Query: 564 GPLDVRLRKLAGEKEELLSQIRK---LKLQLEEERQKCSRN-DGTVGDLAGLQNGSDLQF 619
+++ L++ EKE L IRK KL EE+ Q + + T+ D + +
Sbjct: 1056 QEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQD-----KTNQIDL 1110
Query: 620 IEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDE----- 674
++ + N+ I + KL + D + S++ ++ V+ ++E + E
Sbjct: 1111 LQAEISENQAIIQ---KLITSNTDASD-GDSVALVKETVVISPPCTGSSEHWKPELEEKI 1166
Query: 675 --LKAEKRKLQRELRTALDK----IEEMEMTNSHLAKRLEKMKANRTALLAQ 720
L+ EK +LQ++L+ AL +++ + HL + L++ K + L Q
Sbjct: 1167 LALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQ 1218
Score = 57.8 bits (138), Expect = 4e-08
Identities = 94/478 (19%), Positives = 202/478 (42%), Gaps = 52/478 (10%)
Query: 267 YFSRSNRRGSVVSEVDDIS--IPDLSSLDEKSDKQYA--ENYTRPSS---RNSASATTPL 319
Y S N + SE+ + + DLS+ EK +Q E R +NS + L
Sbjct: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQL 2359
Query: 320 SGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQ-------IQDVEGRYMQGLKELKESL 372
+ + S + +S + + ++ E + I L + I ++ ++ + +KEL+ L
Sbjct: 2360 E--TDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLL 2417
Query: 373 SEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELER-- 430
S+ EE+ N + ++ N L+ + T+K +Q+ Q+ F + + +R
Sbjct: 2418 SQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIV 2477
Query: 431 -------QKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWK 483
++H+ S++ K + ++E + ++L EE + ++ +D + E L L+
Sbjct: 2478 GDYQQLEERHL-SIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQY 2536
Query: 484 DKKIGAL-----EKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPD----GTP 534
+ + + +QK+ + + L + A L+E +K E+ +
Sbjct: 2537 REDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE 2596
Query: 535 NGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEE------LLSQIRKLK 588
D+S E + +SQ QV EG L + +L ++EE L S +K
Sbjct: 2597 KQDLSKE-IESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRI 2655
Query: 589 LQLEEE----RQKCSRNDGTVGD-----LAGLQNGSDLQFIEMQRDANRQISEYKFKLSK 639
+LEEE +++ ++ G + D L L + + + E + A +++E L +
Sbjct: 2656 AELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETE-TAEERVAELARDLVE 2714
Query: 640 AEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEME 697
EQ + + + L Q+ + + + + D E +L+R+ +L ++ +++
Sbjct: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLK 2772
Score = 57.4 bits (137), Expect = 5e-08
Identities = 80/409 (19%), Positives = 170/409 (41%), Gaps = 60/409 (14%)
Query: 341 LSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQV 400
L LR++ D++Q + + + + L LSE E K + ++ L Q+
Sbjct: 1384 LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQL 1443
Query: 401 DTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQ 460
+ +E+ +Q+ E ++K +E+ + +Q K L+ L R E ++E +
Sbjct: 1444 EMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRK---LQAALISRKEALKENK 1500
Query: 461 RMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYI----ACLRNERDML--------- 507
+Q+++ + L ++L + ++ A K+K+ + A L+ ERD L
Sbjct: 1501 SLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLL 1560
Query: 508 -REELADLQETVK------TGEKHGLVIIPDGTPNGDVS---------------HEPVAG 545
+ L+ E++K T +K LV + + ++ +E +
Sbjct: 1561 ENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQ 1620
Query: 546 AITVVSQEAAQ---VLESAGEGPLDV--RLRKLAGEKEELLSQIRKLKLQLEEERQKCSR 600
+ VS EA + V+E+ + ++ +LR K+E Q+++ + ++EE ++K +
Sbjct: 1621 SYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRK 1680
Query: 601 NDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLR 660
+ +E++ + +R +E A++ + TL S + ++ ++ R
Sbjct: 1681 ----------FAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELER 1730
Query: 661 YKTAAENAEKVEDELKAEKRKLQRELRTALDKIE-------EMEMTNSH 702
K E K L +EK L E++ +IE +E T H
Sbjct: 1731 VKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKH 1779
Score = 54.3 bits (129), Expect = 4e-07
Identities = 80/380 (21%), Positives = 161/380 (42%), Gaps = 42/380 (11%)
Query: 347 IYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKK----AMVSNAQLDNEKNNLIYQVDT 402
+ +LKD I+ + + Q + L+E + K KK A L+ + Q T
Sbjct: 61 VVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGT 120
Query: 403 LKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRM 462
+ + EEQ+++ + + E+ E+E+ KH LQ K EEL L+ +L + +
Sbjct: 121 VLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHK---LQEK-EELISTLQA--QLTQAQAEQ 174
Query: 463 QQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGE 522
+ T +E +++ L K++ I L+ Q + + ++RE+ A + V+ E
Sbjct: 175 PAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHE 234
Query: 523 KHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLS 582
L ++ DV E Q+ +VL+ RKL +E L+
Sbjct: 235 DELLQLV----TQADVETE---------MQQKLRVLQ-----------RKLEEHEESLVG 270
Query: 583 QIRKLKLQLEEERQKCSRNDGTVGDLAGL--QNGSDLQFIEMQRDANRQISEYKFKLSKA 640
+ + + L +E RN L + ++ + +E +R+ ++ + E K +L A
Sbjct: 271 RAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLE-KMELEVA 329
Query: 641 EQDIT--TLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEM 698
E+ ++ L++ + L Q ++ A + ++E A ++K + E+ I ++
Sbjct: 330 ERKLSFHNLQEEMHHLLEQ---FEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQK 386
Query: 699 TNSHLAKRLEKMKANRTALL 718
T L + +K + LL
Sbjct: 387 TGQELQSACDALKDQNSKLL 406
Score = 50.4 bits (119), Expect = 6e-06
Identities = 82/436 (18%), Positives = 177/436 (40%), Gaps = 80/436 (18%)
Query: 346 DIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKD 405
+++ D ++ + +KE L V+ +Y+ L +EK++L +V LK
Sbjct: 1702 EVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKH 1761
Query: 406 VIEEQ--------------------EEQMAEFYRENEEKSKELERQKHMC--SVLQHKM- 442
IE EE E EE+ + C SV K
Sbjct: 1762 QIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSA 1821
Query: 443 -----------EELKEGLRQRDE-------LIEEKQRMQQKIDTMTKEVFDLQETLLWKD 484
+E+ L+Q D+ L EEKQ+ ++ T+ E L + KD
Sbjct: 1822 NPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKD 1881
Query: 485 KKIGALEKQ-----------KEYIACLRNERDMLREELADLQETV--KTGEKHGLVIIPD 531
++ L+++ +E ++ + ++ EE DL+E + + E +G +
Sbjct: 1882 GELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSI---- 1937
Query: 532 GTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQL 591
G DV+ + + + E + + E L+ ++L EK ++ S+IRK L+
Sbjct: 1938 GNYCQDVTDAQIKNEL--LESEMKNLKKCVSE--LEEEKQQLVKEKTKVESEIRKEYLEK 1993
Query: 592 EEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDA----------NRQISEYKFKLSKAE 641
+ QK N +L L + ++Q+D R + +F ++++
Sbjct: 1994 IQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQ 2053
Query: 642 QDITTLEQSIS-------RLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIE 694
+D+ +++++ + + ++ +K ++ + + A+ KL++EL++ + ++
Sbjct: 2054 KDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVK 2113
Query: 695 -EMEMTNSHLAKRLEK 709
+M+ + L +RLE+
Sbjct: 2114 SQMKQKDEDLERRLEQ 2129
Score = 45.8 bits (107), Expect = 1e-04
Identities = 72/386 (18%), Positives = 152/386 (39%), Gaps = 66/386 (17%)
Query: 350 LKDQIQDVEGRYMQGLKELK----ESLSEVEEKYKKAMVSNAQL------DNEKNNLIYQ 399
L QIQ GR M L+ + E L E++ KY ++ AQL + E++ L+ +
Sbjct: 2729 LTAQIQSF-GRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSE 2787
Query: 400 VDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEK 459
T + +E ++ + N++ + E+ H+ S L+ +++ + L E+
Sbjct: 2788 --TAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNER 2845
Query: 460 QRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVK 519
+ +++ K Q + ++ K+ ++ L+N+RD L +EL +LQ
Sbjct: 2846 DHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQ---- 2901
Query: 520 TGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEE 579
Q+ Q+ + E L L + +E
Sbjct: 2902 --------------------------------QQYLQINQEITE------LHPLKAQLQE 2923
Query: 580 LLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSK 639
+ + ++ EE RQ+ + L ++ ++ M+ IS+ +LS
Sbjct: 2924 YQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSH 2983
Query: 640 AEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDE----LKAEKRKLQRELRTALDKIEE 695
+ I L S S+ + ++Y+ A + L E L+ +L +L +I +
Sbjct: 2984 LQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQ 3043
Query: 696 MEMTNSHLAKRLEKMKANRTALLAQQ 721
E+ R++++ +N + LL ++
Sbjct: 3044 KEL-------RIQQLNSNFSQLLEEK 3062
Score = 45.4 bits (106), Expect = 2e-04
Identities = 82/382 (21%), Positives = 161/382 (42%), Gaps = 59/382 (15%)
Query: 349 DLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIE 408
+L+++I +E Q K+L+E+L+ +KA++ AQ ++ +L ++ KD
Sbjct: 1161 ELEEKILALEKEKEQLQKKLQEALTS-----RKAILKKAQ--EKERHLREELKQQKDDYN 1213
Query: 409 EQEEQMAEFYRENEEKSKELER-----------------QKHMCSVLQHKMEELKEGLRQ 451
+EQ E +ENE +L + Q+ CS E L + Q
Sbjct: 1214 RLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQ 1273
Query: 452 RDELIEEKQRMQQKIDTMTKEVFDLQ-----ETLLWKDKKIGALEKQKEY-IACLRNERD 505
+ + + +++ LQ + + K+I A + + E ++ +E
Sbjct: 1274 HHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELT 1333
Query: 506 MLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGP 565
EE+ LQE + K GL I T VSHE A ++ + + L+ AG
Sbjct: 1334 KKSEEVFQLQEQIN---KQGLEIESLKT----VSHEAEVHAESLQQKLESSQLQIAG--- 1383
Query: 566 LDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRD 625
L +R+L+ +L+E ++ S+ + V L+G + + ++Q +
Sbjct: 1384 ---------------LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTE 1428
Query: 626 ANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRE 685
Q K ++ E ++ I +L+ ++ K + E++ +E +A K+++QR+
Sbjct: 1429 IIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMK---QKPEEIGEESRA-KQQIQRK 1484
Query: 686 LRTALDKIEEMEMTNSHLAKRL 707
L+ AL +E N L + L
Sbjct: 1485 LQAALISRKEALKENKSLQEEL 1506
Score = 40.0 bits (92), Expect = 0.008
Identities = 90/501 (17%), Positives = 198/501 (39%), Gaps = 47/501 (9%)
Query: 241 NDDTASIVSSDRAS--RGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDL----SSLDE 294
N+ A ++SS + E + S NR G EV +ISI D+ SS E
Sbjct: 482 NEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAE 541
Query: 295 KSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQI 354
+S + EN S ++ + L ++ + + ++ D K ++
Sbjct: 542 ESGQDVLENTF--SQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQK-EM 598
Query: 355 QDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQL---DNEKNNLIYQVDTLKDVIEEQE 411
+ +EG + +K +K L + + + + L + E+ + +Q T +++
Sbjct: 599 KQMEGEGIAPIK-MKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEI--SLN 655
Query: 412 EQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQK-IDTMT 470
+ E ++ K L + Q ++E LK + + + + Q + +K +D
Sbjct: 656 DAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKA 715
Query: 471 KEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQ--ETVKTGEKHGLVI 528
KE+ +L + L+ + KK + L ERD L ++ +L ++ K +
Sbjct: 716 KEISNLNQ-LIEEFKK--NADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMN 772
Query: 529 IPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLK 588
+ + + +E +++++ + S DV++ L E +++ Q +
Sbjct: 773 LAEAERQRRLDYESQTAHDNLLTEQIHSL--SIEAKSKDVKIEVLQNELDDVQLQFSEQS 830
Query: 589 LQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQ-RDANRQISEYKFKLSKAEQ----- 642
+ + + + V L+ ++ I + + ++ +S+ + +++K +Q
Sbjct: 831 TLIRSLQSQLQNKESEV-----LEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEK 885
Query: 643 --DITTLEQSISRLEGQV------LRYKTAAENAEKVE-----DELKAEKRKLQRELRTA 689
D+ TL+Q+I + QV + K N EK LK + L R
Sbjct: 886 KRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAK 945
Query: 690 LDKIEEMEMTNSHLAKRLEKM 710
+++EE +S L + ++M
Sbjct: 946 KEQVEEDNEVSSGLKQNYDEM 966
Score = 40.0 bits (92), Expect = 0.008
Identities = 92/480 (19%), Positives = 188/480 (39%), Gaps = 90/480 (18%)
Query: 269 SRSNRRGSVVSEVDDISIPDLSSLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGS 328
S N R E+D++ +SL E + Q E R++ + T S NS+
Sbjct: 2742 SLQNSRDHANEELDELKRKYDASLKELA--QLKEQGLLNRERDALLSETAFSMNSTE--- 2796
Query: 329 GDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQ 388
+ SLS L L Q+ + + + +L++S ++V+ + KAM S
Sbjct: 2797 ---------ENSLSHLEK---LNQQLLSKDEQLLHLSSQLEDSYNQVQS-FSKAMAS--- 2840
Query: 389 LDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEG 448
L NE+++L +++ + E ++ A+ E++ K S LQ+
Sbjct: 2841 LQNERDHLWNELEKFRKSEEGKQRSAAQ----PSTSPAEVQSLKKAMSSLQN-------- 2888
Query: 449 LRQRDELIEEKQRMQQKIDTMTKEVFDL-------------------------QETLLWK 483
RD L++E + +QQ+ + +E+ +L QE L W+
Sbjct: 2889 --DRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQ 2946
Query: 484 DK-----------KIGALEKQKEYIACLRNERDMLREELADLQETVK-----TGEKHGLV 527
+ +I +++Y+ + +++D ++L+ LQ ++ + + L
Sbjct: 2947 HELHQLRMEKSSWEIHERRMKEQYLMAI-SDKD---QQLSHLQNLIRELRSSSSQTQPLK 3002
Query: 528 IIPDGTPNGDVSHEPVAGAITVVSQE--AAQVLESAGE-GPLDVRLRKLAGEKEELLSQI 584
+ + + S P V E Q+ +S E ++R+++L +LL +
Sbjct: 3003 VQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEK 3062
Query: 585 RKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR-----DANRQISEYKFKLSK 639
L +QL + Q N GDL + Q E+Q D + K + +
Sbjct: 3063 NTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHR 3122
Query: 640 AE--QDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEME 697
+++ +QS S + Q+ + K+ +E + ++ + L A ++I +E
Sbjct: 3123 KSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLE 3182
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 68.9 bits (167), Expect = 2e-11
Identities = 86/440 (19%), Positives = 194/440 (44%), Gaps = 74/440 (16%)
Query: 345 RDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMV-SNAQLDNEKNNLIYQVDTL 403
++I DL +QI + G+ + L+++K+ + + + + + A+ + A L++E+ ++ L
Sbjct: 1513 QEISDLTEQIAE-GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLEL 1571
Query: 404 KDVIEEQEEQMAEFYRENEEKSKELERQK-HMCSVLQHKMEELKEGLRQRDELIEEKQRM 462
V E + ++AE K +E+++ K + +++ L +R R++ I K++M
Sbjct: 1572 NQVKSEVDRKIAE-------KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKM 1624
Query: 463 QQKIDTMTKEVFD------------------LQETLLWKDKKIGALEKQKEYIACLRNER 504
+ ++ M ++ L++T + D + + E KE +A +
Sbjct: 1625 EGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRA 1684
Query: 505 DMLREELADLQETVKTGEKHGLVI---IPDGTPNGDVSH-----------------EPVA 544
++L+ E+ +L+ T++ E+ + + D + + H +
Sbjct: 1685 NLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQ 1744
Query: 545 GAITVVSQEAAQVLESAGEGPLDV-----RLRK-------LAGEKEELLSQIRKLKLQLE 592
G + + QEA E A + D L+K L K+ + ++ L+L+L+
Sbjct: 1745 GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLD 1804
Query: 593 EERQ--------KCSRNDGTVGDLAG---LQNGSDLQFIEMQRDANRQISEYKFKLSKAE 641
E Q + + + V +L G + + + ++ R R++ E ++ +
Sbjct: 1805 EAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDR 1864
Query: 642 QDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNS 701
++I L+ + +L+ +V YK AE AE+ + A+ RKLQ EL A E ++ S
Sbjct: 1865 KNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA---EERADIAES 1921
Query: 702 HLAKRLEKMKANRTALLAQQ 721
+ K K + T +++++
Sbjct: 1922 QVNKLRVKSREVHTKVISEE 1941
Score = 66.6 bits (161), Expect = 8e-11
Identities = 86/385 (22%), Positives = 171/385 (44%), Gaps = 67/385 (17%)
Query: 346 DIYDLKDQIQDVEGRYMQ---GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDT 402
+I +L+ +I+D + +Q +KEL+ + E+EE+ + S A+ + ++++L +++
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151
Query: 403 LKDVIEEQEEQMAEFYRENEEKSKELERQKHMC--SVLQHK----------MEELKEGLR 450
+ + +EE + N+++ E ++ + + LQH+ + + E
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1211
Query: 451 QRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREE 510
Q D L KQ+++++ M E+ DL + K G LEK R D L E
Sbjct: 1212 QIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKM------CRTLEDQLSE- 1264
Query: 511 LADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRL 570
+K+ E+ +I D T G + S E ++ L+ + +
Sbjct: 1265 -------LKSKEEEQQRLINDLTAQ--------RGRLQTESGEFSRQLDEK-----EALV 1304
Query: 571 RKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDL---QFIEMQRDAN 627
+L+ K+ QI +LK QLEEE + L ++ DL Q+ E Q
Sbjct: 1305 SQLSRGKQAFTQQIEELKRQLEEE---IKAKNALAHALQSSRHDCDLLREQYEEEQE--- 1358
Query: 628 RQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAE-NAEKVEDELKAEKRKLQREL 686
SKAE L++++S+ +V +++T E +A + +EL+ K+KL + L
Sbjct: 1359 ----------SKAE-----LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1403
Query: 687 RTALDKIEEMEMTNSHLAKRLEKMK 711
+ A + +E + + L K ++++
Sbjct: 1404 QAAEEHVEAVNAKCASLEKTKQRLQ 1428
Score = 64.3 bits (155), Expect = 4e-10
Identities = 88/455 (19%), Positives = 184/455 (40%), Gaps = 51/455 (11%)
Query: 289 LSSLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDP----DTSLSEL 344
+ L+E+ + + A R+ S G TS+ I+ + ++
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1180
Query: 345 RDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK 404
R DL++ E K+ +S++E+ E+ +L+ EK+ + ++D L
Sbjct: 1181 RR--DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1238
Query: 405 DVIEEQ--------------EEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLR 450
+E E+Q++E + EE+ + + LQ + E L
Sbjct: 1239 SNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD 1298
Query: 451 QRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREE 510
+++ L+ + R +Q T+++ +L+ L +++I A + R++ D+LRE+
Sbjct: 1299 EKEALVSQLSRGKQ---AFTQQIEELKRQL---EEEIKAKNALAHALQSSRHDCDLLREQ 1352
Query: 511 LADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA----AQVLESAGEG-- 564
+ QE+ K + L +E A T +EA AQ L++A E
Sbjct: 1353 YEEEQES-KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVE 1411
Query: 565 PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR 624
++ + L K+ L +++ L L +E C+ D + QR
Sbjct: 1412 AVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD------------------KKQR 1453
Query: 625 DANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQR 684
+ ++ ++E+K K + ++ ++ L ++ + K A E + + LK E + LQ+
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ 1513
Query: 685 ELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLA 719
E+ ++I E L K ++++ + L A
Sbjct: 1514 EISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA 1548
Score = 60.1 bits (144), Expect = 7e-09
Identities = 82/396 (20%), Positives = 168/396 (42%), Gaps = 48/396 (12%)
Query: 344 LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL 403
L D + DQ+ + + +KE+ E + EE NA+L +K L + L
Sbjct: 904 LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEE-------INAELTAKKRKLEDECSEL 956
Query: 404 KDVIEEQEEQMAEFYRE---NEEKSKELERQKHMCSVLQHKMEELKEGLRQ-RDELIEEK 459
K I++ E +A+ +E E K K L + K+ + K+ L++ + +++
Sbjct: 957 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016
Query: 460 QRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVK 519
Q + K++T+TK L++ + D G+LE++K+ L + L +L QE++
Sbjct: 1017 QAEEDKVNTLTKAKIKLEQQV---DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIM 1073
Query: 520 --TGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG-PLDVRLRKLAGE 576
EK L E + +S +++ + G L ++++L
Sbjct: 1074 DIENEKQQL-------------DEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQAR 1120
Query: 577 KEELLSQI---RKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEY 633
EEL +I R + + E++R SR + + G+ IEM + + +
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1180
Query: 634 KFKLSKA----EQDITTLEQ----SISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRE 685
+ L +A E TL + S++ L Q+ +N ++V+ +L+ EK +++ E
Sbjct: 1181 RRDLEEATLQHEATAATLRKKHADSVAELGEQI-------DNLQRVKQKLEKEKSEMKME 1233
Query: 686 LRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 721
+ +E + +L K ++ + L +++
Sbjct: 1234 IDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE 1269
Score = 53.1 bits (126), Expect = 9e-07
Identities = 81/353 (22%), Positives = 148/353 (41%), Gaps = 75/353 (21%)
Query: 381 KAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQH 440
K ++ +A+ + E + + +KD + + E + E EEK L ++K+ LQ
Sbjct: 843 KPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKEL----EEKMVTLLKEKND---LQL 895
Query: 441 KMEELKEGLRQR----DELIEEKQRMQQKIDTMTKEVFDLQE---TLLWKDKK------- 486
+++ EGL D+LI+ K +++ KI +T+ D +E L K +K
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 487 -----------IGALEKQKEYIACLRNERDMLREELADLQETVK--TGEKHGLVIIPDGT 533
+ +EK+K N+ L EE+A L ET+ T EK L T
Sbjct: 956 LKKDIDDLELTLAKVEKEKH---ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1012
Query: 534 PNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEE 593
+ + E +T ++L + + E L Q +KL++ LE
Sbjct: 1013 LDDLQAEEDKVNTLTKAK----------------IKLEQQVDDLEGSLEQEKKLRMDLER 1056
Query: 594 ERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDI-------TT 646
++K GDL L S + ++ + ++ + +F++S + I
Sbjct: 1057 AKRKLE------GDLK-LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQ 1109
Query: 647 LEQSISRLEGQV--LRYKTAAENAEKVEDELKAEKRK--LQRELRTALDKIEE 695
L++ I L+ ++ L + AE A + KAEK++ L REL +++EE
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRA----KAEKQRSDLSRELEEISERLEE 1158
Score = 51.2 bits (121), Expect = 3e-06
Identities = 61/251 (24%), Positives = 115/251 (45%), Gaps = 21/251 (8%)
Query: 480 LLWKDKKIGALEKQKEYIACLRNERDMLREELA-------DLQETVKT--GEKHGLVIIP 530
L +K K + + ++ +A ++ E +++ELA +L+E + T EK+ L +
Sbjct: 838 LFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 897
Query: 531 DGTPNGDVSHEPVAGAI--TVVSQEAA--QVLESAGE-----GPLDVRLRKLAGEKEELL 581
G E + T + EA +V E A + L + RKL E EL
Sbjct: 898 QAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 957
Query: 582 SQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLS--K 639
I L+L L + ++ + V +L G D ++ ++ ++ L +
Sbjct: 958 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1017
Query: 640 AEQD-ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEM 698
AE+D + TL ++ +LE QV + + E +K+ +L+ KRKL+ +L+ A + I ++E
Sbjct: 1018 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN 1077
Query: 699 TNSHLAKRLEK 709
L ++L+K
Sbjct: 1078 EKQQLDEKLKK 1088
Score = 50.1 bits (118), Expect = 7e-06
Identities = 74/380 (19%), Positives = 158/380 (41%), Gaps = 54/380 (14%)
Query: 366 KELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE------------- 412
+++K+ L++ E K K+ L EKN+L QV + + + EE
Sbjct: 863 QKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLE 922
Query: 413 ----QMAEFYRENEEKSKELERQKHM----CSVLQHKMEELKEGLRQRDELIEEKQRMQQ 464
++ E + EE + EL +K CS L+ +++L+ L + ++ EK +
Sbjct: 923 AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK---EKHATEN 979
Query: 465 KIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKH 524
K+ +T+E+ L ET I L K+K+ L+ ++L ++ V T K
Sbjct: 980 KVKNLTEEMAGLDET-------IAKLTKEKK---ALQEAHQQTLDDLQAEEDKVNTLTKA 1029
Query: 525 GLVIIP--DGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLS 582
+ + D + + + ++ L+ A E +D+ EK++L
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIE-----NEKQQLDE 1084
Query: 583 QIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQ-RDANRQISEYKFKLSKAE 641
+++K + ++ + K G+Q ++ ++ + + +I + +KAE
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQA-----LGIQLQKKIKELQARIEELEEEIEAERASRAKAE 1139
Query: 642 QDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNS 701
+ + L + + + ++ A ++ + +AE +K++R+L EE + +
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL-------EEATLQHE 1192
Query: 702 HLAKRLEKMKANRTALLAQQ 721
A L K A+ A L +Q
Sbjct: 1193 ATAATLRKKHADSVAELGEQ 1212
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 68.9 bits (167), Expect = 2e-11
Identities = 86/440 (19%), Positives = 194/440 (44%), Gaps = 74/440 (16%)
Query: 345 RDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMV-SNAQLDNEKNNLIYQVDTL 403
++I DL +QI + G+ + L+++K+ + + + + + A+ + A L++E+ ++ L
Sbjct: 1513 QEISDLTEQIAE-GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLEL 1571
Query: 404 KDVIEEQEEQMAEFYRENEEKSKELERQK-HMCSVLQHKMEELKEGLRQRDELIEEKQRM 462
V E + ++AE K +E+++ K + +++ L +R R++ I K++M
Sbjct: 1572 NQVKSEVDRKIAE-------KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKM 1624
Query: 463 QQKIDTMTKEVFD------------------LQETLLWKDKKIGALEKQKEYIACLRNER 504
+ ++ M ++ L++T + D + + E KE +A +
Sbjct: 1625 EGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRA 1684
Query: 505 DMLREELADLQETVKTGEKHGLVI---IPDGTPNGDVSH-----------------EPVA 544
++L+ E+ +L+ T++ E+ + + D + + H +
Sbjct: 1685 NLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQ 1744
Query: 545 GAITVVSQEAAQVLESAGEGPLDV-----RLRK-------LAGEKEELLSQIRKLKLQLE 592
G + + QEA E A + D L+K L K+ + ++ L+L+L+
Sbjct: 1745 GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLD 1804
Query: 593 EERQ--------KCSRNDGTVGDLAG---LQNGSDLQFIEMQRDANRQISEYKFKLSKAE 641
E Q + + + V +L G + + + ++ R R++ E ++ +
Sbjct: 1805 EAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDR 1864
Query: 642 QDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNS 701
++I L+ + +L+ +V YK AE AE+ + A+ RKLQ EL A E ++ S
Sbjct: 1865 KNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEA---EERADIAES 1921
Query: 702 HLAKRLEKMKANRTALLAQQ 721
+ K K + T +++++
Sbjct: 1922 QVNKLRVKSREVHTKVISEE 1941
Score = 66.6 bits (161), Expect = 8e-11
Identities = 86/385 (22%), Positives = 171/385 (44%), Gaps = 67/385 (17%)
Query: 346 DIYDLKDQIQDVEGRYMQ---GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDT 402
+I +L+ +I+D + +Q +KEL+ + E+EE+ + S A+ + ++++L +++
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151
Query: 403 LKDVIEEQEEQMAEFYRENEEKSKELERQKHMC--SVLQHK----------MEELKEGLR 450
+ + +EE + N+++ E ++ + + LQH+ + + E
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1211
Query: 451 QRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREE 510
Q D L KQ+++++ M E+ DL + K G LEK R D L E
Sbjct: 1212 QIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKM------CRTLEDQLSE- 1264
Query: 511 LADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRL 570
+K+ E+ +I D T G + S E ++ L+ + +
Sbjct: 1265 -------LKSKEEEQQRLINDLTAQ--------RGRLQTESGEFSRQLDEK-----EALV 1304
Query: 571 RKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDL---QFIEMQRDAN 627
+L+ K+ QI +LK QLEEE + L ++ DL Q+ E Q
Sbjct: 1305 SQLSRGKQAFTQQIEELKRQLEEE---IKAKNALAHALQSSRHDCDLLREQYEEEQE--- 1358
Query: 628 RQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAE-NAEKVEDELKAEKRKLQREL 686
SKAE L++++S+ +V +++T E +A + +EL+ K+KL + L
Sbjct: 1359 ----------SKAE-----LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1403
Query: 687 RTALDKIEEMEMTNSHLAKRLEKMK 711
+ A + +E + + L K ++++
Sbjct: 1404 QAAEEHVEAVNAKCASLEKTKQRLQ 1428
Score = 64.3 bits (155), Expect = 4e-10
Identities = 88/455 (19%), Positives = 184/455 (40%), Gaps = 51/455 (11%)
Query: 289 LSSLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDP----DTSLSEL 344
+ L+E+ + + A R+ S G TS+ I+ + ++
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1180
Query: 345 RDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK 404
R DL++ E K+ +S++E+ E+ +L+ EK+ + ++D L
Sbjct: 1181 RR--DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1238
Query: 405 DVIEEQ--------------EEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLR 450
+E E+Q++E + EE+ + + LQ + E L
Sbjct: 1239 SNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD 1298
Query: 451 QRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREE 510
+++ L+ + R +Q T+++ +L+ L +++I A + R++ D+LRE+
Sbjct: 1299 EKEALVSQLSRGKQ---AFTQQIEELKRQL---EEEIKAKNALAHALQSSRHDCDLLREQ 1352
Query: 511 LADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA----AQVLESAGEG-- 564
+ QE+ K + L +E A T +EA AQ L++A E
Sbjct: 1353 YEEEQES-KAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVE 1411
Query: 565 PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR 624
++ + L K+ L +++ L L +E C+ D + QR
Sbjct: 1412 AVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD------------------KKQR 1453
Query: 625 DANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQR 684
+ ++ ++E+K K + ++ ++ L ++ + K A E + + LK E + LQ+
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ 1513
Query: 685 ELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLA 719
E+ ++I E L K ++++ + L A
Sbjct: 1514 EISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA 1548
Score = 60.1 bits (144), Expect = 7e-09
Identities = 82/396 (20%), Positives = 168/396 (42%), Gaps = 48/396 (12%)
Query: 344 LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL 403
L D + DQ+ + + +KE+ E + EE NA+L +K L + L
Sbjct: 904 LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEE-------INAELTAKKRKLEDECSEL 956
Query: 404 KDVIEEQEEQMAEFYRE---NEEKSKELERQKHMCSVLQHKMEELKEGLRQ-RDELIEEK 459
K I++ E +A+ +E E K K L + K+ + K+ L++ + +++
Sbjct: 957 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016
Query: 460 QRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVK 519
Q + K++T+TK L++ + D G+LE++K+ L + L +L QE++
Sbjct: 1017 QAEEDKVNTLTKAKIKLEQQV---DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIM 1073
Query: 520 --TGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG-PLDVRLRKLAGE 576
EK L E + +S +++ + G L ++++L
Sbjct: 1074 DIENEKQQL-------------DEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQAR 1120
Query: 577 KEELLSQI---RKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEY 633
EEL +I R + + E++R SR + + G+ IEM + + +
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1180
Query: 634 KFKLSKA----EQDITTLEQ----SISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRE 685
+ L +A E TL + S++ L Q+ +N ++V+ +L+ EK +++ E
Sbjct: 1181 RRDLEEATLQHEATAATLRKKHADSVAELGEQI-------DNLQRVKQKLEKEKSEMKME 1233
Query: 686 LRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 721
+ +E + +L K ++ + L +++
Sbjct: 1234 IDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE 1269
Score = 53.1 bits (126), Expect = 9e-07
Identities = 81/353 (22%), Positives = 148/353 (41%), Gaps = 75/353 (21%)
Query: 381 KAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQH 440
K ++ +A+ + E + + +KD + + E + E EEK L ++K+ LQ
Sbjct: 843 KPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKEL----EEKMVTLLKEKND---LQL 895
Query: 441 KMEELKEGLRQR----DELIEEKQRMQQKIDTMTKEVFDLQE---TLLWKDKK------- 486
+++ EGL D+LI+ K +++ KI +T+ D +E L K +K
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 487 -----------IGALEKQKEYIACLRNERDMLREELADLQETVK--TGEKHGLVIIPDGT 533
+ +EK+K N+ L EE+A L ET+ T EK L T
Sbjct: 956 LKKDIDDLELTLAKVEKEKH---ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1012
Query: 534 PNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEE 593
+ + E +T ++L + + E L Q +KL++ LE
Sbjct: 1013 LDDLQAEEDKVNTLTKAK----------------IKLEQQVDDLEGSLEQEKKLRMDLER 1056
Query: 594 ERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDI-------TT 646
++K GDL L S + ++ + ++ + +F++S + I
Sbjct: 1057 AKRKLE------GDLK-LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQ 1109
Query: 647 LEQSISRLEGQV--LRYKTAAENAEKVEDELKAEKRK--LQRELRTALDKIEE 695
L++ I L+ ++ L + AE A + KAEK++ L REL +++EE
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRA----KAEKQRSDLSRELEEISERLEE 1158
Score = 51.2 bits (121), Expect = 3e-06
Identities = 61/251 (24%), Positives = 115/251 (45%), Gaps = 21/251 (8%)
Query: 480 LLWKDKKIGALEKQKEYIACLRNERDMLREELA-------DLQETVKT--GEKHGLVIIP 530
L +K K + + ++ +A ++ E +++ELA +L+E + T EK+ L +
Sbjct: 838 LFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 897
Query: 531 DGTPNGDVSHEPVAGAI--TVVSQEAA--QVLESAGE-----GPLDVRLRKLAGEKEELL 581
G E + T + EA +V E A + L + RKL E EL
Sbjct: 898 QAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 957
Query: 582 SQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLS--K 639
I L+L L + ++ + V +L G D ++ ++ ++ L +
Sbjct: 958 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1017
Query: 640 AEQD-ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEM 698
AE+D + TL ++ +LE QV + + E +K+ +L+ KRKL+ +L+ A + I ++E
Sbjct: 1018 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN 1077
Query: 699 TNSHLAKRLEK 709
L ++L+K
Sbjct: 1078 EKQQLDEKLKK 1088
Score = 50.1 bits (118), Expect = 7e-06
Identities = 74/380 (19%), Positives = 158/380 (41%), Gaps = 54/380 (14%)
Query: 366 KELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE------------- 412
+++K+ L++ E K K+ L EKN+L QV + + + EE
Sbjct: 863 QKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLE 922
Query: 413 ----QMAEFYRENEEKSKELERQKHM----CSVLQHKMEELKEGLRQRDELIEEKQRMQQ 464
++ E + EE + EL +K CS L+ +++L+ L + ++ EK +
Sbjct: 923 AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK---EKHATEN 979
Query: 465 KIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKH 524
K+ +T+E+ L ET I L K+K+ L+ ++L ++ V T K
Sbjct: 980 KVKNLTEEMAGLDET-------IAKLTKEKK---ALQEAHQQTLDDLQAEEDKVNTLTKA 1029
Query: 525 GLVIIP--DGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLS 582
+ + D + + + ++ L+ A E +D+ EK++L
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIE-----NEKQQLDE 1084
Query: 583 QIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQ-RDANRQISEYKFKLSKAE 641
+++K + ++ + K G+Q ++ ++ + + +I + +KAE
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQA-----LGIQLQKKIKELQARIEELEEEIEAERASRAKAE 1139
Query: 642 QDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNS 701
+ + L + + + ++ A ++ + +AE +K++R+L EE + +
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL-------EEATLQHE 1192
Query: 702 HLAKRLEKMKANRTALLAQQ 721
A L K A+ A L +Q
Sbjct: 1193 ATAATLRKKHADSVAELGEQ 1212
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 68.9 bits (167), Expect = 2e-11
Identities = 92/450 (20%), Positives = 190/450 (42%), Gaps = 87/450 (19%)
Query: 345 RDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK 404
R+ +L+ +I D+ + +G K + E EK KK QLD+EK+ L ++ +
Sbjct: 1504 RENKNLQQEISDLTEQIAEGGKHIHEL-----EKVKK------QLDHEKSELQTSLEEAE 1552
Query: 405 DVIEEQEEQM-----------AEFYRENEEKSKELERQK-HMCSVLQHKMEELKEGLRQR 452
+E +E ++ +E R+ EK +EL++ K + V++ L +R R
Sbjct: 1553 ASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSR 1612
Query: 453 DELIEEKQRMQQKIDTMTKEVFD------------------LQETLLWKDKKIGALEKQK 494
++ + K++M+ ++ M ++ L++T L D I + K
Sbjct: 1613 NDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLK 1672
Query: 495 EYIACLRNERDMLREELADLQ---ETVKTGEKHGLVIIPDGTPNGDVSH----------- 540
E +A + ++++ E+ +L+ E + G K + D + + H
Sbjct: 1673 EQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKK 1732
Query: 541 ------EPVAGAITVVSQEAAQVLESAGEGPLDV-----RLRK-------LAGEKEELLS 582
+ G + + QEA E A + D L+K L K+ +
Sbjct: 1733 KLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1792
Query: 583 QIRKLKLQLEEERQ--------KCSRNDGTVGDLAG---LQNGSDLQFIEMQRDANRQIS 631
++ L+L+L+E Q + + + V +L + +++ ++ R R++
Sbjct: 1793 TVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVK 1852
Query: 632 EYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALD 691
E ++ + ++I L+ + +L+ +V YK AE AE+ + A+ RKLQ EL A
Sbjct: 1853 ELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAK- 1911
Query: 692 KIEEMEMTNSHLAKRLEKMKANRTALLAQQ 721
E ++ S + K K + T +++++
Sbjct: 1912 --ERADIAESQVNKLRVKSREVHTKVISEE 1939
Score = 63.2 bits (152), Expect = 8e-10
Identities = 88/386 (22%), Positives = 172/386 (44%), Gaps = 73/386 (18%)
Query: 346 DIYDLKDQIQDVEGRYMQ---GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDT 402
++ +L+ +I+D + +Q +KEL+ + E+EE+ + S A+ + ++++L +++
Sbjct: 1090 EMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149
Query: 403 LKDVIEEQEEQMAEFYRENEEKSKELERQKHMC--SVLQHK------MEELKEGLRQRDE 454
+ + +EE + N+++ E ++ + S LQH+ ++ + + + E
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGE 1209
Query: 455 LIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADL 514
I+ QR++QK++ KE +L+ +I L E ++ + + + L D
Sbjct: 1210 QIDSLQRVKQKLE---KEKSELK-------MEINDLASNMETVSKAKANFEKMCRTLEDQ 1259
Query: 515 QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGE-----GPLDVR 569
+KT E E I +S + A++ +GE D
Sbjct: 1260 LSEIKTKE------------------EEQQRLINELSAQKARLHTESGEFSRQLDEKDAM 1301
Query: 570 LRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDL---QFIEMQRDA 626
+ +L+ K+ QI +LK QLEEE + S L ++ DL Q+ E Q
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEETKAKST---LAHALQSARHDCDLLREQYEEEQE-- 1356
Query: 627 NRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAE-NAEKVEDELKAEKRKLQRE 685
+KAE L++ +S+ +V +++T E +A + +EL+ K+KL +
Sbjct: 1357 -----------AKAE-----LQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1400
Query: 686 LRTALDKIEEMEMTNSHLAKRLEKMK 711
L+ D E +E NS A LEK K
Sbjct: 1401 LQ---DAEEHVEAVNSKCAS-LEKTK 1422
Score = 62.0 bits (149), Expect = 2e-09
Identities = 77/350 (22%), Positives = 150/350 (42%), Gaps = 60/350 (17%)
Query: 366 KELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKS 425
++ KE L++ E K K+ L EKN+L QV D + + EE+ + + +
Sbjct: 861 EKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQ-- 918
Query: 426 KELERQKHMCSVLQHKMEELKEGLRQRD----ELIEEKQRMQQKIDTMTKEVFDLQETLL 481
L+ K++E+ E + EL +K++++ + + K++ DL+ TL
Sbjct: 919 ------------LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL- 965
Query: 482 WKDKKIGALEKQKEYIACLRNERDMLREELADLQETVK--TGEKHGLVIIPDGTPNGDVS 539
+EK+K N+ L EE+A L ET+ T EK L +
Sbjct: 966 ------AKVEKEKH---ATENKVKNLTEEMAGLDETIAKLTKEKKAL----------QEA 1006
Query: 540 HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCS 599
H+ + + ++ L A +L + + E L Q +KL + LE ++K
Sbjct: 1007 HQQTLDDLQ-MEEDKVNTLTKA-----KTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLE 1060
Query: 600 RNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVL 659
GDL L S + ++ N ++ + +F++S + I + +L+ ++
Sbjct: 1061 ------GDLK-LAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKI- 1112
Query: 660 RYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 709
K E++E+E++AE+ + + D E+E +++RLE+
Sbjct: 1113 --KELQARIEELEEEIEAERASRAKAEKQRSDLSRELE----EISERLEE 1156
Score = 62.0 bits (149), Expect = 2e-09
Identities = 72/365 (19%), Positives = 155/365 (42%), Gaps = 42/365 (11%)
Query: 360 RYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL-------KDVIEEQEE 412
++ + EL E + ++ +K ++L E N+L ++T+ + + E+
Sbjct: 1199 KHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLED 1258
Query: 413 QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKE 472
Q++E + EE+ + + + L + E L ++D ++ + R +Q T++
Sbjct: 1259 QLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQ---AFTQQ 1315
Query: 473 VFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDG 532
+ +L+ L +++ A + R++ D+LRE+ + QE K + G+
Sbjct: 1316 IEELKRQL---EEETKAKSTLAHALQSARHDCDLLREQYEEEQEA-KAELQRGMSKANSE 1371
Query: 533 TPNGDVSHEPVAGAITVVSQEA----AQVLESAGEG--PLDVRLRKLAGEKEELLSQIRK 586
+E A T +EA AQ L+ A E ++ + L K+ L +++
Sbjct: 1372 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVED 1431
Query: 587 LKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITT 646
L + +E C D + QR+ ++ ++E+K K + + ++
Sbjct: 1432 LMIDVERSNAACIALD------------------KKQRNFDKVLAEWKQKYEETQAELEA 1473
Query: 647 LEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKR 706
++ L ++ + K A E + + LK E + LQ+E+ D E++ H+
Sbjct: 1474 SQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEIS---DLTEQIAEGGKHI-HE 1529
Query: 707 LEKMK 711
LEK+K
Sbjct: 1530 LEKVK 1534
Score = 58.2 bits (139), Expect = 3e-08
Identities = 85/377 (22%), Positives = 162/377 (42%), Gaps = 37/377 (9%)
Query: 344 LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL 403
L D + DQ+ + + +KE+ E + EE NA+L +K L + L
Sbjct: 902 LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEE-------INAELTAKKRKLEDECSEL 954
Query: 404 KDVIEEQEEQMAEFYRE---NEEKSKELERQKHMCSVLQHKMEELKEGLRQ-RDELIEEK 459
K I++ E +A+ +E E K K L + K+ + K+ L++ + +++
Sbjct: 955 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1014
Query: 460 QRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVK 519
Q + K++T+TK L++ + D G+LE++K+ L + L +L QE+
Sbjct: 1015 QMEEDKVNTLTKAKTKLEQQV---DDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTM 1071
Query: 520 TGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEE 579
E + + + + + G I A Q+ + E L R+ +L EE
Sbjct: 1072 DTE-NDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKE--LQARIEEL----EE 1124
Query: 580 LLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSK 639
+ R + + E++R SR + + G+ IEM + E +F+ +
Sbjct: 1125 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK-----REAEFQKMR 1179
Query: 640 AEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMT 699
+ + +TL+ + + + AE E++ D L+ K+KL++E E++M
Sbjct: 1180 RDLEESTLQHEATAAALRKKHADSVAELGEQI-DSLQRVKQKLEKEK-------SELKME 1231
Query: 700 NSHLAKRLE---KMKAN 713
+ LA +E K KAN
Sbjct: 1232 INDLASNMETVSKAKAN 1248
Score = 45.4 bits (106), Expect = 2e-04
Identities = 74/370 (20%), Positives = 157/370 (42%), Gaps = 55/370 (14%)
Query: 372 LSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKEL--- 428
L+E ++KY++ E +L ++ +K+ EE + + REN+ +E+
Sbjct: 1457 LAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDL 1516
Query: 429 -----ERQKHMCSV------LQHKMEELKEGLRQRDELIEEKQ----RMQQKIDTMTKEV 473
E KH+ + L H+ EL+ L + + +E ++ R+Q +++ + E+
Sbjct: 1517 TEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576
Query: 474 FDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGT 533
+ KD+++ L ++ ++ + + + L E+ + ++ +K
Sbjct: 1577 ---DRKIAEKDEELDQL--KRNHLRVVESMQSTLDAEIRSRNDALRIKKK---------- 1621
Query: 534 PNGDVSHEPVAGAITVVSQEAAQVLESAGEGP---------LDVRLRKLAGEKEELLSQI 584
GD++ + + +++AA+ L + LD +R KE+L
Sbjct: 1622 MEGDLNEMEI--QLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVE 1679
Query: 585 RKLKL-QLEEERQKCSRNDGTVGDLAGLQNGSDL-QFIEMQRDANRQISEYKFKLSKAEQ 642
R+ L Q E E + S G Q D + +++ N + K KL E
Sbjct: 1680 RRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKL---ET 1736
Query: 643 DITTLEQSISRLEGQVLRYKTAAENAEK--VEDELKAEKRKLQRELRTALDKIEE-MEMT 699
DI+ ++ +E V + A E A+K + + AE+ K +++ L+++++ ME T
Sbjct: 1737 DISQIQ---GEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1793
Query: 700 NSHLAKRLEK 709
L RL++
Sbjct: 1794 VKDLQLRLDE 1803
Score = 40.8 bits (94), Expect = 0.004
Identities = 31/132 (23%), Positives = 68/132 (51%), Gaps = 14/132 (10%)
Query: 579 ELLSQIRKLKLQLEEERQKCSRNDGTVGDLAG-----LQNGSDLQFIEMQRDANRQISEY 633
E ++ +K + E+ +++ ++ + +L +Q +DLQ +++Q +A+
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQ-LQVQAEADA----- 901
Query: 634 KFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI 693
L+ AE+ L ++ +LE ++ AE+ E++ EL A+KRKL+ E I
Sbjct: 902 ---LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 958
Query: 694 EEMEMTNSHLAK 705
+++E+T + + K
Sbjct: 959 DDLELTLAKVEK 970
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 68.6 bits (166), Expect = 2e-11
Identities = 83/414 (20%), Positives = 185/414 (44%), Gaps = 49/414 (11%)
Query: 344 LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL 403
L ++ L + ++ V ++L + +V + ++ + N QL EKN ++ +
Sbjct: 658 LSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKME 717
Query: 404 KDVIEEQ----EEQMAEFYRENEEKSKELERQKHM-CSVLQHKMEELKEGLRQRDELIEE 458
K IE + ++++ E + E+ +EL +++ S LQ + E L + +++D I E
Sbjct: 718 KGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAE 777
Query: 459 KQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKE-YIACLRNERDMLREELADLQET 517
++ +++DT KE D+ + L + K++ L +KE +I L+ L+EEL +
Sbjct: 778 LKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQA 837
Query: 518 VKTGEKHGLVIIPDGTPNGDVSHE--PVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAG 575
++ E I G + E + + + +E ++ A LD + +LA
Sbjct: 838 LRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLD-SVTELAS 896
Query: 576 EKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKF 635
E +SQ+ +K LEEE + + D QN S +Q ++ ++ +++ E+++
Sbjct: 897 E----VSQLNTIKEHLEEE---IKHHQKIIED----QNQSKMQLLQSLQEQKKEMDEFRY 945
Query: 636 K-----------LSKAEQDITTLEQSISRLEGQVLRYK------------------TAAE 666
+ + +++I +L+++I +++ Q+ + E
Sbjct: 946 QHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIE 1005
Query: 667 NAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 720
N + D KAE +L + ++ +I+ + N L K+++++ + L Q
Sbjct: 1006 NGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQ 1059
Score = 52.0 bits (123), Expect = 2e-06
Identities = 81/415 (19%), Positives = 152/415 (36%), Gaps = 96/415 (23%)
Query: 338 DTSLSELRDIYD--LKDQIQ-----DVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLD 390
DT E +D+ L++Q Q + + +++ LKE L E +KY +A+ N
Sbjct: 786 DTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKN---- 841
Query: 391 NEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHM---------------- 434
+ L+ IEE++ + EN +ELER +
Sbjct: 842 ----------EILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSV 891
Query: 435 ------CSVLQHKMEELKEGLRQRDELIEE----KQRMQQKIDTMTKEVFDLQ------- 477
S L E L+E ++ ++IE+ K ++ Q + KE+ + +
Sbjct: 892 TELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMN 951
Query: 478 ----ETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGT 533
+ L KD++I +L+K E I + L EE D+Q T
Sbjct: 952 ATHTQLFLEKDEEIKSLQKTIEQI------KTQLHEERQDIQ-----------------T 988
Query: 534 PNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEE 593
N D+ E ++ + + L A E E L+ I++ +L+++
Sbjct: 989 DNSDIFQETKVQSLNIENGSEKHDLSKA--------------ETERLVKGIKERELEIKL 1034
Query: 594 ERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISR 653
+K + L+ + G Q I+ Q+D Q + + QD+ L+Q +
Sbjct: 1035 LNEKNISLTKQIDQLSKDEVGKLTQIIQ-QKDLEIQALHARISSTSHTQDVVYLQQQLQA 1093
Query: 654 LEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLE 708
+ + + LK E K+ + + +++ N L+ R E
Sbjct: 1094 YAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFE 1148
Score = 43.9 bits (102), Expect = 5e-04
Identities = 78/387 (20%), Positives = 160/387 (41%), Gaps = 28/387 (7%)
Query: 311 NSASATTPLSGNSSRRGSGD----TSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLK 366
+SAS TP S R + +S L+ + L ELR KD L
Sbjct: 1317 SSASLLTPQSAECLRASKSEVLSESSELLQQE--LEELRKSLQEKDATIRTLQENNHRLS 1374
Query: 367 ELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDV-IEEQEEQMAEFYRENEEKS 425
+ + SE+E K + S + EK +++ ++ KD+ I+ + +Q+ K
Sbjct: 1375 DSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKV 1434
Query: 426 KELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDK 485
E E + + L+ ++ L+ + +L E +++ + E LQET +
Sbjct: 1435 NENELLRQAVTNLKERILILEMDI---GKLKGENEKIVETYRGKETEYQALQET----NM 1487
Query: 486 KIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAG 545
K + ++KE+ E+ + E+L +E KTGE + L+ V +
Sbjct: 1488 KFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERD 1547
Query: 546 AITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLE----------EER 595
+ +++ + Q+ +A + + RLR + L ++R L+ E E+R
Sbjct: 1548 QV-MLALKQKQMENTALQNEVQ-RLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDR 1605
Query: 596 QKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLE 655
+ R TV + + + + ++ Q + + + + ++D T L+ S+S +
Sbjct: 1606 EAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVS--Q 1663
Query: 656 GQVLRYKTAAENAEKVEDELKAEKRKL 682
QV +Y + N + V + + E++ +
Sbjct: 1664 EQVKQYALSLANLQMVLEHFQQEEKAM 1690
Score = 43.9 bits (102), Expect = 5e-04
Identities = 53/226 (23%), Positives = 98/226 (43%), Gaps = 23/226 (10%)
Query: 308 SSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKE 367
S + A A L + +G+ + L++ S+ E ++ Q + M LK+
Sbjct: 1502 SMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVF------QQERDQVMLALKQ 1555
Query: 368 LKES----LSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKD---VIEEQEEQMAEFYRE 420
+ +EV+ K SN +L+ +N+L+ D+ E++E ++ +
Sbjct: 1556 KQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTV 1615
Query: 421 NEEK----SKELERQKHMCSV-LQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFD 475
EEK S +E H SV ++ E+L +QRDE + Q+++ + +
Sbjct: 1616 LEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLAN 1675
Query: 476 LQETL--LWKDKKI---GALEKQKEYIACLRNERDMLREELADLQE 516
LQ L +++K LEKQK+ IA + + L ++ LQE
Sbjct: 1676 LQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQE 1721
Score = 42.4 bits (98), Expect = 0.002
Identities = 70/354 (19%), Positives = 147/354 (41%), Gaps = 78/354 (22%)
Query: 367 ELKESLSEVEEKYKKAMVSNAQ-LDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKS 425
E+ SEV A S AQ DN + ++ L+++I+E ++ +S
Sbjct: 180 EVSRLESEVGHWRHIAQTSKAQGTDNSDQS---EICKLQNIIKELKQN----------RS 226
Query: 426 KELERQKHMCSVLQ--HKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWK 483
+E++ +H SVLQ H+ + + R R+EL + ++R+++ + + + + ET L K
Sbjct: 227 QEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSK 286
Query: 484 DKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPV 543
+ + ++ I L+ E+ +++ L++ +K K
Sbjct: 287 ------IYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKK------------------- 321
Query: 544 AGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDG 603
S+ E D+ R E+E+L + R++ + E + +CS+
Sbjct: 322 ---------------LSSAENDRDILRR----EQEQLNVEKRQIMEECENLKLECSK--- 359
Query: 604 TVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKT 663
LQ +++ E S + +++ L+Q++S E +++R +
Sbjct: 360 -------------LQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSS 406
Query: 664 AAENAEKVEDELKAEKR--KLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRT 715
++ ED LK + R L++E + EE++M+ L E +K+ T
Sbjct: 407 LNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTAT 460
Score = 40.4 bits (93), Expect = 0.006
Identities = 72/380 (18%), Positives = 159/380 (41%), Gaps = 57/380 (15%)
Query: 345 RDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK 404
RDI + + +VE R + E E+L K + + V + EK ++ Q +++
Sbjct: 329 RDILRREQEQLNVEKRQIM---EECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVE 385
Query: 405 DVIE------------------EQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELK 446
+V Q+ +AE + + + + LE++K S+L + EEL+
Sbjct: 386 EVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEK---SLLSQEKEELQ 442
Query: 447 EGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDM 506
L + + E + + ++ E+ DL+ L K++++ +KE
Sbjct: 443 MSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKE----------T 492
Query: 507 LREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPL 566
L E+ +L + KH +++I D + + + + + + + +
Sbjct: 493 LIAEIEELDRQNQEATKH-MILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKM 551
Query: 567 DVRLRKLAGEKEELL-SQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRD 625
D+ ++L +KE+L+ S++ L L +++ + V +L N S + +Q++
Sbjct: 552 DI-TKELDVQKEKLIQSEVALNDLHLTKQKL-----EDKVENLVDQLNKSQESNVSIQKE 605
Query: 626 ANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRE 685
N ++ E+ I E+ +SR+ ++++ N+ +D L E+ + E
Sbjct: 606 -NLELKEH----------IRQNEEELSRIRNELMQSLNQDSNS-NFKDTLLKER---EAE 650
Query: 686 LRTALDKIEEMEMTNSHLAK 705
+R + E+E N +L K
Sbjct: 651 VRNLKQNLSELEQLNENLKK 670
Score = 37.7 bits (86), Expect = 0.038
Identities = 68/370 (18%), Positives = 140/370 (37%), Gaps = 58/370 (15%)
Query: 385 SNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEK-----SKELERQKHMCSVLQ 439
S A L + +N + D L + EE E ++ + + E E ER K +C+ L+
Sbjct: 22 SLASLTGQISN--FTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLE 79
Query: 440 HKMEELKEGLRQRDELIEEK-QRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIA 498
K E + ++Q+ + Q+ + +I + LQ+ LL
Sbjct: 80 EKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLK---------------- 123
Query: 499 CLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGA---ITVVSQEAA 555
L++ + T + +G+ P + D+ + + I +S E +
Sbjct: 124 -LQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVS 182
Query: 556 QVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRN-DGTVGDLAGLQNG 614
++ G + K G S+I KL+ ++E +Q S+ D +++ LQN
Sbjct: 183 RLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNA 242
Query: 615 SDLQFIEMQRDANRQISEYKFKLSKAEQ------------DITTL--------------- 647
+ E+ R ++S+Y+ ++ + E D++ +
Sbjct: 243 HQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKV 302
Query: 648 --EQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAK 705
+ + +LE ++ +AE D L+ E+ +L E R +++ E +++ S L
Sbjct: 303 ESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQP 362
Query: 706 RLEKMKANRT 715
K T
Sbjct: 363 SAVKQSDTMT 372
Score = 32.3 bits (72), Expect = 1.6
Identities = 44/208 (21%), Positives = 86/208 (41%), Gaps = 65/208 (31%)
Query: 353 QIQDVEGRYMQGLKELKESLSEVEEKY----------------------KKAMVSNAQLD 390
+++D E R Q L+ L+ L E E+ Y +K + S+ ++
Sbjct: 1569 RLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAME 1628
Query: 391 NEKNNLIYQVDTLKD-----------------VIEEQEEQMA----------EFYRENEE 423
N + QV++L++ V +EQ +Q A E +++ E+
Sbjct: 1629 NASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEK 1688
Query: 424 K--SKELERQKHMCSV-------LQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVF 474
S ELE+QK + + L+ K+ L+E L + + ++ R+ +++D +++
Sbjct: 1689 AMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIE 1748
Query: 475 DL-------QETLLWKDKKIGALEKQKE 495
+L QE L KK+ +L E
Sbjct: 1749 ELKRQNELRQEMLDDVQKKLMSLANSSE 1776
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 68.2 bits (165), Expect = 3e-11
Identities = 109/536 (20%), Positives = 229/536 (42%), Gaps = 118/536 (22%)
Query: 283 DISIPDLSSLDEKSDKQYAENYTRPSSRNSASATTPLSGN-SSRRGSGDTSS-LIDPDTS 340
D I L S EK++K+ N R +S S + L+ + R +G+++S L+D +T+
Sbjct: 1260 DEEIQQLRSKLEKAEKE--RNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETA 1317
Query: 341 --------LSELRDIYD-LKDQIQDVEGRYMQG-LKELKESLSEVEE---------KYKK 381
+ EL+ YD LK Q++ +E M+ L E EV++ KY++
Sbjct: 1318 ERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYER 1377
Query: 382 AMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQM----AEFYRENEEKSKELERQKHMCSV 437
A+ ++D K L + + +V ++ + Q+ + ++EE + L++ K C
Sbjct: 1378 AV---REVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQR 1434
Query: 438 LQHKMEELK---EGLRQRDELIEEKQR----------------------MQQKIDTMTKE 472
L ++++ K EG + R+ +E+KQR +Q++ D + E
Sbjct: 1435 LTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAE 1494
Query: 473 VFDLQETLLWKD-------KKIGALEKQKEYIACLRNERDM----LREELADLQETVKTG 521
F L++ L KD +K+ +LE + + I+ ++ + ++++L DL+ VK
Sbjct: 1495 AFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQ 1554
Query: 522 EKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQV------LESAGEGPLDVRLRKLAG 575
E+ + AG I ++ Q ++ + ++ R ++
Sbjct: 1555 EEE---------------LDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEE 1599
Query: 576 EKEELLSQIRKLKLQLEEE---RQKCSRN----DGTVGDLAGLQNGSD------------ 616
++ +++++++QLEEE +QK R +G + L+ N D
Sbjct: 1600 ARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLK 1659
Query: 617 ------------LQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTA 664
L ++ + R+I++ K +L ++E ++ +E ++
Sbjct: 1660 RTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQ 1719
Query: 665 AENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 720
++ K + L+ + +LQRE +++EE + + L K+ + A + LAQ
Sbjct: 1720 IDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ 1775
Score = 67.0 bits (162), Expect = 6e-11
Identities = 91/419 (21%), Positives = 185/419 (44%), Gaps = 67/419 (15%)
Query: 347 IYDLKDQIQDV---EGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL 403
+ L+ ++QD+ E + L ++K+ L ++E K K +LD E+ I ++
Sbjct: 1516 VVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKD---QEEELD-EQAGTIQMLEQA 1571
Query: 404 KDVIEEQEEQMAEFY-RENEEKSKELERQKHMCSVLQHKME-ELKEGLRQRDELIEEKQR 461
K +E + E+M + + +E E + +E+E + C +ME +L+E + +++ EK+
Sbjct: 1572 KLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRE 1631
Query: 462 MQQKIDTMTKEV----FDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQET 517
++ K+ T++ +V F+ ++ L K+ AL + + + E+A L+
Sbjct: 1632 LEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQ 1691
Query: 518 VKTGE----------KHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLD 567
++ E K V I D + + +A A T + ++ +++ E +
Sbjct: 1692 LEESEFTCAAAVKARKAMEVEIEDL----HLQIDDIAKAKTALEEQLSRLQREKNE--IQ 1745
Query: 568 VRLRKLAGEKEEL--------------LSQIRKLKLQLEE---ERQKCSRNDGTVGDLAG 610
RL + + EL L+QI L+ QLEE E+Q+ L
Sbjct: 1746 NRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEK------LQA 1799
Query: 611 LQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEK 670
LQ S ++F+E +S + K+ + E + + RLE R K EN EK
Sbjct: 1800 LQ--SQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLK---ENMEK 1854
Query: 671 VEDEL----------KAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLA 719
+ +E K + ++LQR+LR +++ E+ + +++ +++ + +L A
Sbjct: 1855 LTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEA 1913
Score = 52.8 bits (125), Expect = 1e-06
Identities = 88/432 (20%), Positives = 188/432 (43%), Gaps = 62/432 (14%)
Query: 349 DLKDQIQDVEGRYMQG------LKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDT 402
+L+D +EG+ ++ + LS+ E+ ++ + +L EK+ L+ + +
Sbjct: 1438 ELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFS 1497
Query: 403 LKDVIEEQEEQMAEFYRE-----------NEEKSKE---LERQKHMCSVLQHKMEELKEG 448
LK +EE++ +A F ++ + ++SK+ L + K L+ K+++ +E
Sbjct: 1498 LKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEE 1557
Query: 449 LRQRDELIE-----------EKQRMQQ----KIDTMTKEVFDLQETLLWKDKKIGA-LEK 492
L ++ I+ E +RM+Q ++++ +EV + +++ K K++ LE+
Sbjct: 1558 LDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEE 1617
Query: 493 QKEYIACLRNERDMLREELADLQETVKTGE-----------KHGLVIIPDGTPNGDVSHE 541
+ E + E+ L +LA L + V + K ++ D D +
Sbjct: 1618 EYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLD-HLK 1676
Query: 542 PVAGAITVVSQEAAQVLESAGEGPLDVRLRK-LAGEKEEL---LSQIRKLKLQLEEERQK 597
A + ++Q Q+ ES V+ RK + E E+L + I K K LEE+ +
Sbjct: 1677 NSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSR 1736
Query: 598 CSRNDGTV--------GDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQ 649
R + D+ L + RD QI++ + +L +A ++ L++
Sbjct: 1737 LQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDL-AQINDLQAQLEEANKEKQELQE 1795
Query: 650 SISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 709
+ L+ QV + + + V + +A+ R+L+ L +++ +E S L + +EK
Sbjct: 1796 KLQALQSQVEFLEQSMVDKSLVSRQ-EAKIRELETRLEFERTQVKRLESLASRLKENMEK 1854
Query: 710 MKANRTALLAQQ 721
+ R +A +
Sbjct: 1855 LTEERDQRIAAE 1866
Score = 34.3 bits (77), Expect = 0.42
Identities = 28/104 (26%), Positives = 49/104 (47%), Gaps = 16/104 (15%)
Query: 621 EMQRDANRQISEYKFKLSKAEQD-------ITTLEQSISRLEGQVLRYKTAAENAEKVED 673
E R+ + +I + + KL KAE++ LE IS L ++ + E+A ++ D
Sbjct: 1254 EQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLD 1313
Query: 674 ELKAEK---RKLQRELRTALD------KIEEMEMTNSHLAKRLE 708
AE+ K +EL+T D ++ EME+ + L + E
Sbjct: 1314 AETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAE 1357
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 68.2 bits (165), Expect = 3e-11
Identities = 109/536 (20%), Positives = 229/536 (42%), Gaps = 118/536 (22%)
Query: 283 DISIPDLSSLDEKSDKQYAENYTRPSSRNSASATTPLSGN-SSRRGSGDTSS-LIDPDTS 340
D I L S EK++K+ N R +S S + L+ + R +G+++S L+D +T+
Sbjct: 1260 DEEIQQLRSKLEKAEKE--RNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETA 1317
Query: 341 --------LSELRDIYD-LKDQIQDVEGRYMQG-LKELKESLSEVEE---------KYKK 381
+ EL+ YD LK Q++ +E M+ L E EV++ KY++
Sbjct: 1318 ERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYER 1377
Query: 382 AMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQM----AEFYRENEEKSKELERQKHMCSV 437
A+ ++D K L + + +V ++ + Q+ + ++EE + L++ K C
Sbjct: 1378 AV---REVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQR 1434
Query: 438 LQHKMEELK---EGLRQRDELIEEKQR----------------------MQQKIDTMTKE 472
L ++++ K EG + R+ +E+KQR +Q++ D + E
Sbjct: 1435 LTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAE 1494
Query: 473 VFDLQETLLWKD-------KKIGALEKQKEYIACLRNERDM----LREELADLQETVKTG 521
F L++ L KD +K+ +LE + + I+ ++ + ++++L DL+ VK
Sbjct: 1495 AFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQ 1554
Query: 522 EKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQV------LESAGEGPLDVRLRKLAG 575
E+ + AG I ++ Q ++ + ++ R ++
Sbjct: 1555 EEE---------------LDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEE 1599
Query: 576 EKEELLSQIRKLKLQLEEE---RQKCSRN----DGTVGDLAGLQNGSD------------ 616
++ +++++++QLEEE +QK R +G + L+ N D
Sbjct: 1600 ARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLK 1659
Query: 617 ------------LQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTA 664
L ++ + R+I++ K +L ++E ++ +E ++
Sbjct: 1660 RTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQ 1719
Query: 665 AENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 720
++ K + L+ + +LQRE +++EE + + L K+ + A + LAQ
Sbjct: 1720 IDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ 1775
Score = 67.0 bits (162), Expect = 6e-11
Identities = 91/419 (21%), Positives = 185/419 (44%), Gaps = 67/419 (15%)
Query: 347 IYDLKDQIQDV---EGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL 403
+ L+ ++QD+ E + L ++K+ L ++E K K +LD E+ I ++
Sbjct: 1516 VVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKD---QEEELD-EQAGTIQMLEQA 1571
Query: 404 KDVIEEQEEQMAEFY-RENEEKSKELERQKHMCSVLQHKME-ELKEGLRQRDELIEEKQR 461
K +E + E+M + + +E E + +E+E + C +ME +L+E + +++ EK+
Sbjct: 1572 KLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRE 1631
Query: 462 MQQKIDTMTKEV----FDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQET 517
++ K+ T++ +V F+ ++ L K+ AL + + + E+A L+
Sbjct: 1632 LEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQ 1691
Query: 518 VKTGE----------KHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLD 567
++ E K V I D + + +A A T + ++ +++ E +
Sbjct: 1692 LEESEFTCAAAVKARKAMEVEIEDL----HLQIDDIAKAKTALEEQLSRLQREKNE--IQ 1745
Query: 568 VRLRKLAGEKEEL--------------LSQIRKLKLQLEE---ERQKCSRNDGTVGDLAG 610
RL + + EL L+QI L+ QLEE E+Q+ L
Sbjct: 1746 NRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEK------LQA 1799
Query: 611 LQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEK 670
LQ S ++F+E +S + K+ + E + + RLE R K EN EK
Sbjct: 1800 LQ--SQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLK---ENMEK 1854
Query: 671 VEDEL----------KAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLA 719
+ +E K + ++LQR+LR +++ E+ + +++ +++ + +L A
Sbjct: 1855 LTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEA 1913
Score = 52.8 bits (125), Expect = 1e-06
Identities = 88/432 (20%), Positives = 188/432 (43%), Gaps = 62/432 (14%)
Query: 349 DLKDQIQDVEGRYMQG------LKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDT 402
+L+D +EG+ ++ + LS+ E+ ++ + +L EK+ L+ + +
Sbjct: 1438 ELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFS 1497
Query: 403 LKDVIEEQEEQMAEFYRE-----------NEEKSKE---LERQKHMCSVLQHKMEELKEG 448
LK +EE++ +A F ++ + ++SK+ L + K L+ K+++ +E
Sbjct: 1498 LKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEE 1557
Query: 449 LRQRDELIE-----------EKQRMQQ----KIDTMTKEVFDLQETLLWKDKKIGA-LEK 492
L ++ I+ E +RM+Q ++++ +EV + +++ K K++ LE+
Sbjct: 1558 LDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEE 1617
Query: 493 QKEYIACLRNERDMLREELADLQETVKTGE-----------KHGLVIIPDGTPNGDVSHE 541
+ E + E+ L +LA L + V + K ++ D D +
Sbjct: 1618 EYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLD-HLK 1676
Query: 542 PVAGAITVVSQEAAQVLESAGEGPLDVRLRK-LAGEKEEL---LSQIRKLKLQLEEERQK 597
A + ++Q Q+ ES V+ RK + E E+L + I K K LEE+ +
Sbjct: 1677 NSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSR 1736
Query: 598 CSRNDGTV--------GDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQ 649
R + D+ L + RD QI++ + +L +A ++ L++
Sbjct: 1737 LQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDL-AQINDLQAQLEEANKEKQELQE 1795
Query: 650 SISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 709
+ L+ QV + + + V + +A+ R+L+ L +++ +E S L + +EK
Sbjct: 1796 KLQALQSQVEFLEQSMVDKSLVSRQ-EAKIRELETRLEFERTQVKRLESLASRLKENMEK 1854
Query: 710 MKANRTALLAQQ 721
+ R +A +
Sbjct: 1855 LTEERDQRIAAE 1866
Score = 34.3 bits (77), Expect = 0.42
Identities = 28/104 (26%), Positives = 49/104 (47%), Gaps = 16/104 (15%)
Query: 621 EMQRDANRQISEYKFKLSKAEQD-------ITTLEQSISRLEGQVLRYKTAAENAEKVED 673
E R+ + +I + + KL KAE++ LE IS L ++ + E+A ++ D
Sbjct: 1254 EQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLD 1313
Query: 674 ELKAEK---RKLQRELRTALD------KIEEMEMTNSHLAKRLE 708
AE+ K +EL+T D ++ EME+ + L + E
Sbjct: 1314 AETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAE 1357
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 67.8 bits (164), Expect = 3e-11
Identities = 73/386 (18%), Positives = 164/386 (42%), Gaps = 42/386 (10%)
Query: 340 SLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQ 399
S +L+D + +++ + R+ + ++ L + E Y K + +L E ++L+
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 400 VDTLKDVIEEQEEQMAEF----YRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 455
+D + ++ E++ +F E SK + + + + K + R +E
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495
Query: 456 IEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQ 515
+E K+ +++ + E+ DL + K + LEK K L + + ++ +L +L+
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR---ALETQMEEMKTQLEELE 1552
Query: 516 ETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAG 575
+ ++ E L + + Q L+ E L R +
Sbjct: 1553 DELQATEDAKLRL-----------------------EVNMQALKGQFERDLQARDEQNEE 1589
Query: 576 EKEELLSQIRKLKLQLEEERQK----CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQIS 631
++ +L Q+ + + +LE+ER++ + GDL L+ +D I+ + +A +Q+
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD-SAIKGREEAIKQLR 1648
Query: 632 EYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALD 691
+ + ++ ++++ S + + TA EN EK L+A+ +LQ +L A
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEI------FATAKEN-EKKAKSLEADLMQLQEDLAAAER 1701
Query: 692 KIEEMEMTNSHLAKRLEKMKANRTAL 717
++ ++ LA+ L + R AL
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNAL 1727
Score = 67.0 bits (162), Expect = 6e-11
Identities = 81/352 (23%), Positives = 152/352 (43%), Gaps = 65/352 (18%)
Query: 365 LKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEK 424
L++ KE + E + K+ ++QL EKN +++EQ + E Y E EE
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKN-----------LLQEQLQAETELYAEAEEM 909
Query: 425 SKELERQKHMCSVLQHKME-ELKEGLRQRDELIEEKQRMQQKI----DTMTKEVFDLQET 479
L +K + H+ME L+E + +L E+++M Q++ + + +E Q+
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
Query: 480 LLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVS 539
L K ++K ++ I + ++ + L +E L+E I D T N
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER-----------ISDLTTNLAEE 1018
Query: 540 HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCS 599
E + ++ + + E L+VRL+K +E+ ++ KLK +LE
Sbjct: 1019 EEKAKNLTKLKNKHESMISE------LEVRLKK----EEKSRQELEKLKRKLE------- 1061
Query: 600 RNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVL 659
G F E D QI+E K +L+K E++ L+ +++RL+ ++
Sbjct: 1062 --------------GDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIA 1104
Query: 660 RYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 711
+ A + ++E + + L E R A +K E+ + L + LE +K
Sbjct: 1105 QKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQK---RDLGEELEALK 1152
Score = 66.6 bits (161), Expect = 8e-11
Identities = 90/392 (22%), Positives = 156/392 (39%), Gaps = 77/392 (19%)
Query: 330 DTSSLIDPDTSLSELRDIYDLKDQIQDVE--GRYMQGLKELKESL-SEVEEKYKKAMVSN 386
D ++ + + L E R I DL + + E + + LK ES+ SE+E + KK S
Sbjct: 992 DQNNKLSKERKLLEER-ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1050
Query: 387 AQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELK 446
+L+ K L + I + + Q+AE + L K EEL+
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ-----------------LAKKEEELQ 1093
Query: 447 EGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDM 506
L + D+ I +K +KI + + DLQE L D + A K ++ L E +
Sbjct: 1094 AALARLDDEIAQKNNALKKIRELEGHISDLQEDL---DSERAARNKAEKQKRDLGEELEA 1150
Query: 507 LREELADL------QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLES 560
L+ EL D Q+ ++ + + ++ SHE + + Q+ AQ +E
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE---AQVQEMRQKHAQAVE- 1206
Query: 561 AGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFI 620
E E L Q ++ K L++ +Q + + DLAG
Sbjct: 1207 ---------------ELTEQLEQFKRAKANLDKNKQTLEKENA---DLAG---------- 1238
Query: 621 EMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKR 680
E++ L +A+Q++ E +LE QV ++ + E+ EL +
Sbjct: 1239 ELR------------VLGQAKQEV---EHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 681 KLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 712
KLQ E+ + + E E LAK + + +
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Score = 64.7 bits (156), Expect = 3e-10
Identities = 78/390 (20%), Positives = 168/390 (43%), Gaps = 20/390 (5%)
Query: 345 RDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNE---KNNLIYQVD 401
+D+ L Q+QD + + ++ +++ + ++ QLD E K NL +
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367
Query: 402 TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQR 461
TL + + ++++ +F E E +K +++ ++ +E D+L + K R
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALE---EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424
Query: 462 MQQKIDTMTKEVFDLQETLLWKDKKIGA----LEKQKEYIACLRNERDMLREELADLQET 517
+QQ++D + ++ + ++ + +KK L ++K + +ERD E + +ET
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE-KET 1483
Query: 518 VKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEK 577
L + + +++ + + + V ++ E L+ R L +
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE--LEKSKRALETQM 1541
Query: 578 EELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGL----QNGSDLQFIEMQRDANRQISEY 633
EE+ +Q+ +L+ +L+ R + + L G D Q E +R RQ+ EY
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 634 KFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI 693
+ +L + + +LEG + + A++A K +E + RKLQ +++ ++
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 694 EEMEMTNSHL---AKRLEKMKANRTALLAQ 720
E+ + + AK EK + A L Q
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Score = 60.1 bits (144), Expect = 7e-09
Identities = 85/386 (22%), Positives = 170/386 (44%), Gaps = 59/386 (15%)
Query: 349 DLKDQIQDVEGRYMQGLKELKESLSEVEEKYKK---AMVSNAQLDNEKNNLIYQVDTLKD 405
DL+ + + E + Q ++L E +E+E++ K+ A + +L+ + +L Q D+
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS--- 1635
Query: 406 VIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQK 465
I+ +EE + + R+ + + K+ +R EL++ RDE+ + ++K
Sbjct: 1636 AIKGREEAIKQL-RKLQAQMKDFQR-------------ELEDARASRDEIFATAKENEKK 1681
Query: 466 IDTMTKEVFDLQETLLWKDKKIGALEKQKEYIA-----------CLRNERDMLREELADL 514
++ ++ LQE L ++ + +KE +A L++E+ L +A L
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 515 QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG------PLDV 568
+E ++ E+ + + D E ++ + + AQ ESA + L
Sbjct: 1742 EEELEE-EQGNMEAMSDRVRKATQQAEQLSNELAT-ERSTAQKNESARQQLERQNKELRS 1799
Query: 569 RLRKLAGE-KEELLSQIRKLKL---QLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR 624
+L ++ G K + S I L+ QLEE+ ++ +R + + Q L+ I +Q
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR-EKQAATKSLKQKDKKLKEILLQV 1858
Query: 625 DANRQISE-YKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQ 683
+ R+++E YK + K + L++ + E AE+ + A +RKLQ
Sbjct: 1859 EDERKMAEQYKEQAEKGNARVKQLKRQL--------------EEAEEESQRINANRRKLQ 1904
Query: 684 RELRTALDKIEEMEMTNSHLAKRLEK 709
REL A + E M + L +L +
Sbjct: 1905 RELDEATESNEAMGREVNALKSKLRR 1930
Score = 59.7 bits (143), Expect = 9e-09
Identities = 79/336 (23%), Positives = 142/336 (42%), Gaps = 55/336 (16%)
Query: 396 LIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 455
L +V L V ++EE A+ +E K ERQ Q ELKE ++ +L
Sbjct: 837 LFTKVKPLLQVTRQEEEMQAK----EDELQKTKERQ-------QKAENELKELEQKHSQL 885
Query: 456 IEEKQRMQQKIDTMTK---EVFDLQETLLWKDKKI--------GALEKQKEYIACLRNER 504
EEK +Q+++ T+ E +++ L K +++ LE++++ L+ ER
Sbjct: 886 TEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 945
Query: 505 DMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG 564
+ +++ DL+E ++ E + E V + E ++
Sbjct: 946 KKMAQQMLDLEEQLEEEE----------AARQKLQLEKVTAEAKIKKLEDEILV------ 989
Query: 565 PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQ- 623
+D + KL+ E++ L +I L L EE +K +L L+N + E++
Sbjct: 990 -MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK-------NLTKLKNKHESMISELEV 1041
Query: 624 --RDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK 681
+ + E + K E D + + I+ L+ Q+ K K E+EL+A +
Sbjct: 1042 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM---QLAKKEEELQAALAR 1098
Query: 682 LQREL---RTALDKIEEMEMTNSHLAKRLEKMKANR 714
L E+ AL KI E+E S L + L+ +A R
Sbjct: 1099 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Score = 55.8 bits (133), Expect = 1e-07
Identities = 84/387 (21%), Positives = 154/387 (39%), Gaps = 84/387 (21%)
Query: 353 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE 412
Q+Q++ ++ Q ++EL E L E++K+A A LD K L + L +
Sbjct: 1193 QVQEMRQKHAQAVEELTEQL----EQFKRA---KANLDKNKQTLEKENADLAGELRV--- 1242
Query: 413 QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMT-- 470
+ + +E E K K+LE Q +Q + +G R R EL ++ ++Q +++++T
Sbjct: 1243 -LGQAKQEVEHKKKKLEAQ------VQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295
Query: 471 ------------KEVFDLQETLLWKDKKIGALEKQKEYIAC----LRNERDMLREELADL 514
K+V L L + + +QK ++ L ER+ L+++L +
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355
Query: 515 QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLA 574
E + E+H T N +S Q+ A +E+ EG
Sbjct: 1356 MEAKQNLERH------ISTLNIQLSDSKKK------LQDFASTVEALEEG---------- 1393
Query: 575 GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK 634
K+ +I L Q EE+ + + T L +L + + D RQ+
Sbjct: 1394 --KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ-----QELDDLVVDLDNQRQL---- 1442
Query: 635 FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK-------LQRELR 687
++ LE+ + + + K + D +AE R+ L R L
Sbjct: 1443 ---------VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1493
Query: 688 TALDKIEEMEMTNSHLAKRLEKMKANR 714
AL+ EE+E TN L +E + +++
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSK 1520
Score = 50.8 bits (120), Expect = 4e-06
Identities = 87/421 (20%), Positives = 169/421 (40%), Gaps = 83/421 (19%)
Query: 288 DLSSLDEKSD-------KQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL-IDPDT 339
DL + DE+++ +Q E T A L+ + ++ GD L + D+
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA---LAAAAKKKLEGDLKDLELQADS 1635
Query: 340 SLS----ELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNN 395
++ ++ + L+ Q++D + E + +E KKA A
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-------- 1687
Query: 396 LIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 455
D+++ QE+ A E K +LE+++ EEL L R+ L
Sbjct: 1688 ---------DLMQLQEDLAA---AERARKQADLEKEE--------LAEELASSLSGRNAL 1727
Query: 456 IEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQ 515
+EK+R++ +I + +E+ +++ G +E + + + + L ELA +
Sbjct: 1728 QDEKRRLEARIAQLEEEL----------EEEQGNMEAMSDRVRKATQQAEQLSNELATER 1777
Query: 516 ETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAG 575
T + E + HE + GA+ + LE A L+ ++ + A
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHE-MEGAVKSKFKSTIAALE-AKIAQLEEQVEQEAR 1835
Query: 576 EKE----ELLSQIRKLK---LQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANR 628
EK+ L + +KLK LQ+E+ER+ Q+ E N
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAE------------------QYKEQAEKGNA 1877
Query: 629 QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRT 688
++ + K +L +AE++ + + +L+ ++ A E+ E + E+ A K KL+R T
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQREL---DEATESNEAMGREVNALKSKLRRGNET 1934
Query: 689 A 689
+
Sbjct: 1935 S 1935
Score = 44.7 bits (104), Expect = 3e-04
Identities = 56/274 (20%), Positives = 112/274 (40%), Gaps = 19/274 (6%)
Query: 365 LKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEK 424
L +L+E L+ E K+A + +L E + + + L+D E ++A+ E EE+
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748
Query: 425 SKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKD 484
+E + E+L L ++ + +Q+++ KE L+ L +
Sbjct: 1749 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE---LRSKL--HE 1803
Query: 485 KKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVA 544
+ K K IA L ++A L+E V+ E D + +
Sbjct: 1804 MEGAVKSKFKSTIAA-------LEAKIAQLEEQVEQ-EAREKQAATKSLKQKDKKLKEIL 1855
Query: 545 GAITVVSQEAAQVLESAGEGPLDVR-LRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDG 603
+ + A Q E A +G V+ L++ E EE +I + +L+ E + + ++
Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Query: 604 TVGD-----LAGLQNGSDLQFIEMQRDANRQISE 632
+G + L+ G++ F+ +R R++ E
Sbjct: 1916 AMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1949
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 67.8 bits (164), Expect = 3e-11
Identities = 73/386 (18%), Positives = 164/386 (42%), Gaps = 42/386 (10%)
Query: 340 SLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQ 399
S +L+D + +++ + R+ + ++ L + E Y K + +L E ++L+
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 400 VDTLKDVIEEQEEQMAEF----YRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 455
+D + ++ E++ +F E SK + + + + K + R +E
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502
Query: 456 IEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQ 515
+E K+ +++ + E+ DL + K + LEK K L + + ++ +L +L+
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR---ALETQMEEMKTQLEELE 1559
Query: 516 ETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAG 575
+ ++ E L + + Q L+ E L R +
Sbjct: 1560 DELQATEDAKLRL-----------------------EVNMQALKGQFERDLQARDEQNEE 1596
Query: 576 EKEELLSQIRKLKLQLEEERQK----CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQIS 631
++ +L Q+ + + +LE+ER++ + GDL L+ +D I+ + +A +Q+
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD-SAIKGREEAIKQLR 1655
Query: 632 EYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALD 691
+ + ++ ++++ S + + TA EN EK L+A+ +LQ +L A
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEI------FATAKEN-EKKAKSLEADLMQLQEDLAAAER 1708
Query: 692 KIEEMEMTNSHLAKRLEKMKANRTAL 717
++ ++ LA+ L + R AL
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNAL 1734
Score = 67.0 bits (162), Expect = 6e-11
Identities = 81/352 (23%), Positives = 152/352 (43%), Gaps = 65/352 (18%)
Query: 365 LKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEK 424
L++ KE + E + K+ ++QL EKN +++EQ + E Y E EE
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKN-----------LLQEQLQAETELYAEAEEM 916
Query: 425 SKELERQKHMCSVLQHKME-ELKEGLRQRDELIEEKQRMQQKI----DTMTKEVFDLQET 479
L +K + H+ME L+E + +L E+++M Q++ + + +E Q+
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 480 LLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVS 539
L K ++K ++ I + ++ + L +E L+E I D T N
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER-----------ISDLTTNLAEE 1025
Query: 540 HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCS 599
E + ++ + + E L+VRL+K +E+ ++ KLK +LE
Sbjct: 1026 EEKAKNLTKLKNKHESMISE------LEVRLKK----EEKSRQELEKLKRKLE------- 1068
Query: 600 RNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVL 659
G F E D QI+E K +L+K E++ L+ +++RL+ ++
Sbjct: 1069 --------------GDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIA 1111
Query: 660 RYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 711
+ A + ++E + + L E R A +K E+ + L + LE +K
Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQK---RDLGEELEALK 1159
Score = 66.6 bits (161), Expect = 8e-11
Identities = 90/392 (22%), Positives = 156/392 (39%), Gaps = 77/392 (19%)
Query: 330 DTSSLIDPDTSLSELRDIYDLKDQIQDVE--GRYMQGLKELKESL-SEVEEKYKKAMVSN 386
D ++ + + L E R I DL + + E + + LK ES+ SE+E + KK S
Sbjct: 999 DQNNKLSKERKLLEER-ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1057
Query: 387 AQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELK 446
+L+ K L + I + + Q+AE + L K EEL+
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ-----------------LAKKEEELQ 1100
Query: 447 EGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDM 506
L + D+ I +K +KI + + DLQE L D + A K ++ L E +
Sbjct: 1101 AALARLDDEIAQKNNALKKIRELEGHISDLQEDL---DSERAARNKAEKQKRDLGEELEA 1157
Query: 507 LREELADL------QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLES 560
L+ EL D Q+ ++ + + ++ SHE + + Q+ AQ +E
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE---AQVQEMRQKHAQAVE- 1213
Query: 561 AGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFI 620
E E L Q ++ K L++ +Q + + DLAG
Sbjct: 1214 ---------------ELTEQLEQFKRAKANLDKNKQTLEKENA---DLAG---------- 1245
Query: 621 EMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKR 680
E++ L +A+Q++ E +LE QV ++ + E+ EL +
Sbjct: 1246 ELR------------VLGQAKQEV---EHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1290
Query: 681 KLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 712
KLQ E+ + + E E LAK + + +
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Score = 64.7 bits (156), Expect = 3e-10
Identities = 78/390 (20%), Positives = 168/390 (43%), Gaps = 20/390 (5%)
Query: 345 RDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNE---KNNLIYQVD 401
+D+ L Q+QD + + ++ +++ + ++ QLD E K NL +
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374
Query: 402 TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQR 461
TL + + ++++ +F E E +K +++ ++ +E D+L + K R
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALE---EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 462 MQQKIDTMTKEVFDLQETLLWKDKKIGA----LEKQKEYIACLRNERDMLREELADLQET 517
+QQ++D + ++ + ++ + +KK L ++K + +ERD E + +ET
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE-KET 1490
Query: 518 VKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEK 577
L + + +++ + + + V ++ E L+ R L +
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE--LEKSKRALETQM 1548
Query: 578 EELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGL----QNGSDLQFIEMQRDANRQISEY 633
EE+ +Q+ +L+ +L+ R + + L G D Q E +R RQ+ EY
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 634 KFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI 693
+ +L + + +LEG + + A++A K +E + RKLQ +++ ++
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 694 EEMEMTNSHL---AKRLEKMKANRTALLAQ 720
E+ + + AK EK + A L Q
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Score = 60.1 bits (144), Expect = 7e-09
Identities = 85/386 (22%), Positives = 170/386 (44%), Gaps = 59/386 (15%)
Query: 349 DLKDQIQDVEGRYMQGLKELKESLSEVEEKYKK---AMVSNAQLDNEKNNLIYQVDTLKD 405
DL+ + + E + Q ++L E +E+E++ K+ A + +L+ + +L Q D+
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS--- 1642
Query: 406 VIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQK 465
I+ +EE + + R+ + + K+ +R EL++ RDE+ + ++K
Sbjct: 1643 AIKGREEAIKQL-RKLQAQMKDFQR-------------ELEDARASRDEIFATAKENEKK 1688
Query: 466 IDTMTKEVFDLQETLLWKDKKIGALEKQKEYIA-----------CLRNERDMLREELADL 514
++ ++ LQE L ++ + +KE +A L++E+ L +A L
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 515 QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG------PLDV 568
+E ++ E+ + + D E ++ + + AQ ESA + L
Sbjct: 1749 EEELEE-EQGNMEAMSDRVRKATQQAEQLSNELAT-ERSTAQKNESARQQLERQNKELRS 1806
Query: 569 RLRKLAGE-KEELLSQIRKLKL---QLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR 624
+L ++ G K + S I L+ QLEE+ ++ +R + + Q L+ I +Q
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR-EKQAATKSLKQKDKKLKEILLQV 1865
Query: 625 DANRQISE-YKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQ 683
+ R+++E YK + K + L++ + E AE+ + A +RKLQ
Sbjct: 1866 EDERKMAEQYKEQAEKGNARVKQLKRQL--------------EEAEEESQRINANRRKLQ 1911
Query: 684 RELRTALDKIEEMEMTNSHLAKRLEK 709
REL A + E M + L +L +
Sbjct: 1912 RELDEATESNEAMGREVNALKSKLRR 1937
Score = 59.7 bits (143), Expect = 9e-09
Identities = 79/336 (23%), Positives = 142/336 (42%), Gaps = 55/336 (16%)
Query: 396 LIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 455
L +V L V ++EE A+ +E K ERQ Q ELKE ++ +L
Sbjct: 844 LFTKVKPLLQVTRQEEEMQAK----EDELQKTKERQ-------QKAENELKELEQKHSQL 892
Query: 456 IEEKQRMQQKIDTMTK---EVFDLQETLLWKDKKI--------GALEKQKEYIACLRNER 504
EEK +Q+++ T+ E +++ L K +++ LE++++ L+ ER
Sbjct: 893 TEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 952
Query: 505 DMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG 564
+ +++ DL+E ++ E + E V + E ++
Sbjct: 953 KKMAQQMLDLEEQLEEEE----------AARQKLQLEKVTAEAKIKKLEDEILV------ 996
Query: 565 PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQ- 623
+D + KL+ E++ L +I L L EE +K +L L+N + E++
Sbjct: 997 -MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK-------NLTKLKNKHESMISELEV 1048
Query: 624 --RDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK 681
+ + E + K E D + + I+ L+ Q+ K K E+EL+A +
Sbjct: 1049 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM---QLAKKEEELQAALAR 1105
Query: 682 LQREL---RTALDKIEEMEMTNSHLAKRLEKMKANR 714
L E+ AL KI E+E S L + L+ +A R
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Score = 55.8 bits (133), Expect = 1e-07
Identities = 84/387 (21%), Positives = 154/387 (39%), Gaps = 84/387 (21%)
Query: 353 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE 412
Q+Q++ ++ Q ++EL E L E++K+A A LD K L + L +
Sbjct: 1200 QVQEMRQKHAQAVEELTEQL----EQFKRA---KANLDKNKQTLEKENADLAGELRV--- 1249
Query: 413 QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMT-- 470
+ + +E E K K+LE Q +Q + +G R R EL ++ ++Q +++++T
Sbjct: 1250 -LGQAKQEVEHKKKKLEAQ------VQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302
Query: 471 ------------KEVFDLQETLLWKDKKIGALEKQKEYIAC----LRNERDMLREELADL 514
K+V L L + + +QK ++ L ER+ L+++L +
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362
Query: 515 QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLA 574
E + E+H T N +S Q+ A +E+ EG
Sbjct: 1363 MEAKQNLERH------ISTLNIQLSDSKKK------LQDFASTVEALEEG---------- 1400
Query: 575 GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK 634
K+ +I L Q EE+ + + T L +L + + D RQ+
Sbjct: 1401 --KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ-----QELDDLVVDLDNQRQL---- 1449
Query: 635 FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK-------LQRELR 687
++ LE+ + + + K + D +AE R+ L R L
Sbjct: 1450 ---------VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1500
Query: 688 TALDKIEEMEMTNSHLAKRLEKMKANR 714
AL+ EE+E TN L +E + +++
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSK 1527
Score = 50.8 bits (120), Expect = 4e-06
Identities = 87/421 (20%), Positives = 169/421 (40%), Gaps = 83/421 (19%)
Query: 288 DLSSLDEKSD-------KQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL-IDPDT 339
DL + DE+++ +Q E T A L+ + ++ GD L + D+
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA---LAAAAKKKLEGDLKDLELQADS 1642
Query: 340 SLS----ELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNN 395
++ ++ + L+ Q++D + E + +E KKA A
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-------- 1694
Query: 396 LIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 455
D+++ QE+ A E K +LE+++ EEL L R+ L
Sbjct: 1695 ---------DLMQLQEDLAA---AERARKQADLEKEE--------LAEELASSLSGRNAL 1734
Query: 456 IEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQ 515
+EK+R++ +I + +E+ +++ G +E + + + + L ELA +
Sbjct: 1735 QDEKRRLEARIAQLEEEL----------EEEQGNMEAMSDRVRKATQQAEQLSNELATER 1784
Query: 516 ETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAG 575
T + E + HE + GA+ + LE A L+ ++ + A
Sbjct: 1785 STAQKNESARQQLERQNKELRSKLHE-MEGAVKSKFKSTIAALE-AKIAQLEEQVEQEAR 1842
Query: 576 EKE----ELLSQIRKLK---LQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANR 628
EK+ L + +KLK LQ+E+ER+ Q+ E N
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAE------------------QYKEQAEKGNA 1884
Query: 629 QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRT 688
++ + K +L +AE++ + + +L+ ++ A E+ E + E+ A K KL+R T
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQREL---DEATESNEAMGREVNALKSKLRRGNET 1941
Query: 689 A 689
+
Sbjct: 1942 S 1942
Score = 44.7 bits (104), Expect = 3e-04
Identities = 56/274 (20%), Positives = 112/274 (40%), Gaps = 19/274 (6%)
Query: 365 LKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEK 424
L +L+E L+ E K+A + +L E + + + L+D E ++A+ E EE+
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755
Query: 425 SKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKD 484
+E + E+L L ++ + +Q+++ KE L+ L +
Sbjct: 1756 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE---LRSKL--HE 1810
Query: 485 KKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVA 544
+ K K IA L ++A L+E V+ E D + +
Sbjct: 1811 MEGAVKSKFKSTIAA-------LEAKIAQLEEQVEQ-EAREKQAATKSLKQKDKKLKEIL 1862
Query: 545 GAITVVSQEAAQVLESAGEGPLDVR-LRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDG 603
+ + A Q E A +G V+ L++ E EE +I + +L+ E + + ++
Sbjct: 1863 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
Query: 604 TVGD-----LAGLQNGSDLQFIEMQRDANRQISE 632
+G + L+ G++ F+ +R R++ E
Sbjct: 1923 AMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1956
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 67.8 bits (164), Expect = 3e-11
Identities = 73/386 (18%), Positives = 164/386 (42%), Gaps = 42/386 (10%)
Query: 340 SLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQ 399
S +L+D + +++ + R+ + ++ L + E Y K + +L E ++L+
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 400 VDTLKDVIEEQEEQMAEF----YRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 455
+D + ++ E++ +F E SK + + + + K + R +E
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502
Query: 456 IEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQ 515
+E K+ +++ + E+ DL + K + LEK K L + + ++ +L +L+
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR---ALETQMEEMKTQLEELE 1559
Query: 516 ETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAG 575
+ ++ E L + + Q L+ E L R +
Sbjct: 1560 DELQATEDAKLRL-----------------------EVNMQALKGQFERDLQARDEQNEE 1596
Query: 576 EKEELLSQIRKLKLQLEEERQK----CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQIS 631
++ +L Q+ + + +LE+ER++ + GDL L+ +D I+ + +A +Q+
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD-SAIKGREEAIKQLR 1655
Query: 632 EYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALD 691
+ + ++ ++++ S + + TA EN EK L+A+ +LQ +L A
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEI------FATAKEN-EKKAKSLEADLMQLQEDLAAAER 1708
Query: 692 KIEEMEMTNSHLAKRLEKMKANRTAL 717
++ ++ LA+ L + R AL
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNAL 1734
Score = 67.0 bits (162), Expect = 6e-11
Identities = 81/352 (23%), Positives = 152/352 (43%), Gaps = 65/352 (18%)
Query: 365 LKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEK 424
L++ KE + E + K+ ++QL EKN +++EQ + E Y E EE
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKN-----------LLQEQLQAETELYAEAEEM 916
Query: 425 SKELERQKHMCSVLQHKME-ELKEGLRQRDELIEEKQRMQQKI----DTMTKEVFDLQET 479
L +K + H+ME L+E + +L E+++M Q++ + + +E Q+
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
Query: 480 LLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVS 539
L K ++K ++ I + ++ + L +E L+E I D T N
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER-----------ISDLTTNLAEE 1025
Query: 540 HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCS 599
E + ++ + + E L+VRL+K +E+ ++ KLK +LE
Sbjct: 1026 EEKAKNLTKLKNKHESMISE------LEVRLKK----EEKSRQELEKLKRKLE------- 1068
Query: 600 RNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVL 659
G F E D QI+E K +L+K E++ L+ +++RL+ ++
Sbjct: 1069 --------------GDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIA 1111
Query: 660 RYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 711
+ A + ++E + + L E R A +K E+ + L + LE +K
Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQK---RDLGEELEALK 1159
Score = 66.6 bits (161), Expect = 8e-11
Identities = 90/392 (22%), Positives = 156/392 (39%), Gaps = 77/392 (19%)
Query: 330 DTSSLIDPDTSLSELRDIYDLKDQIQDVE--GRYMQGLKELKESL-SEVEEKYKKAMVSN 386
D ++ + + L E R I DL + + E + + LK ES+ SE+E + KK S
Sbjct: 999 DQNNKLSKERKLLEER-ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1057
Query: 387 AQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELK 446
+L+ K L + I + + Q+AE + L K EEL+
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ-----------------LAKKEEELQ 1100
Query: 447 EGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDM 506
L + D+ I +K +KI + + DLQE L D + A K ++ L E +
Sbjct: 1101 AALARLDDEIAQKNNALKKIRELEGHISDLQEDL---DSERAARNKAEKQKRDLGEELEA 1157
Query: 507 LREELADL------QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLES 560
L+ EL D Q+ ++ + + ++ SHE + + Q+ AQ +E
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE---AQVQEMRQKHAQAVE- 1213
Query: 561 AGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFI 620
E E L Q ++ K L++ +Q + + DLAG
Sbjct: 1214 ---------------ELTEQLEQFKRAKANLDKNKQTLEKENA---DLAG---------- 1245
Query: 621 EMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKR 680
E++ L +A+Q++ E +LE QV ++ + E+ EL +
Sbjct: 1246 ELR------------VLGQAKQEV---EHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1290
Query: 681 KLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 712
KLQ E+ + + E E LAK + + +
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Score = 64.7 bits (156), Expect = 3e-10
Identities = 78/390 (20%), Positives = 168/390 (43%), Gaps = 20/390 (5%)
Query: 345 RDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNE---KNNLIYQVD 401
+D+ L Q+QD + + ++ +++ + ++ QLD E K NL +
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374
Query: 402 TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQR 461
TL + + ++++ +F E E +K +++ ++ +E D+L + K R
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALE---EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 462 MQQKIDTMTKEVFDLQETLLWKDKKIGA----LEKQKEYIACLRNERDMLREELADLQET 517
+QQ++D + ++ + ++ + +KK L ++K + +ERD E + +ET
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE-KET 1490
Query: 518 VKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEK 577
L + + +++ + + + V ++ E L+ R L +
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE--LEKSKRALETQM 1548
Query: 578 EELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGL----QNGSDLQFIEMQRDANRQISEY 633
EE+ +Q+ +L+ +L+ R + + L G D Q E +R RQ+ EY
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 634 KFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI 693
+ +L + + +LEG + + A++A K +E + RKLQ +++ ++
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 694 EEMEMTNSHL---AKRLEKMKANRTALLAQ 720
E+ + + AK EK + A L Q
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Score = 59.7 bits (143), Expect = 9e-09
Identities = 79/336 (23%), Positives = 142/336 (42%), Gaps = 55/336 (16%)
Query: 396 LIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 455
L +V L V ++EE A+ +E K ERQ Q ELKE ++ +L
Sbjct: 844 LFTKVKPLLQVTRQEEEMQAK----EDELQKTKERQ-------QKAENELKELEQKHSQL 892
Query: 456 IEEKQRMQQKIDTMTK---EVFDLQETLLWKDKKI--------GALEKQKEYIACLRNER 504
EEK +Q+++ T+ E +++ L K +++ LE++++ L+ ER
Sbjct: 893 TEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 952
Query: 505 DMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG 564
+ +++ DL+E ++ E + E V + E ++
Sbjct: 953 KKMAQQMLDLEEQLEEEE----------AARQKLQLEKVTAEAKIKKLEDEILV------ 996
Query: 565 PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQ- 623
+D + KL+ E++ L +I L L EE +K +L L+N + E++
Sbjct: 997 -MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK-------NLTKLKNKHESMISELEV 1048
Query: 624 --RDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK 681
+ + E + K E D + + I+ L+ Q+ K K E+EL+A +
Sbjct: 1049 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM---QLAKKEEELQAALAR 1105
Query: 682 LQREL---RTALDKIEEMEMTNSHLAKRLEKMKANR 714
L E+ AL KI E+E S L + L+ +A R
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Score = 59.3 bits (142), Expect = 1e-08
Identities = 85/384 (22%), Positives = 169/384 (44%), Gaps = 59/384 (15%)
Query: 349 DLKDQIQDVEGRYMQGLKELKESLSEVEEKYKK---AMVSNAQLDNEKNNLIYQVDTLKD 405
DL+ + + E + Q ++L E +E+E++ K+ A + +L+ + +L Q D+
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS--- 1642
Query: 406 VIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQK 465
I+ +EE + + R+ + + K+ +R EL++ RDE+ + ++K
Sbjct: 1643 AIKGREEAIKQL-RKLQAQMKDFQR-------------ELEDARASRDEIFATAKENEKK 1688
Query: 466 IDTMTKEVFDLQETLLWKDKKIGALEKQKEYIA-----------CLRNERDMLREELADL 514
++ ++ LQE L ++ + +KE +A L++E+ L +A L
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 515 QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG------PLDV 568
+E ++ E+ + + D E ++ + + AQ ESA + L
Sbjct: 1749 EEELEE-EQGNMEAMSDRVRKATQQAEQLSNELAT-ERSTAQKNESARQQLERQNKELRS 1806
Query: 569 RLRKLAGE-KEELLSQIRKLKL---QLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR 624
+L ++ G K + S I L+ QLEE+ ++ +R + + Q L+ I +Q
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR-EKQAATKSLKQKDKKLKEILLQV 1865
Query: 625 DANRQISE-YKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQ 683
+ R+++E YK + K + L++ + E AE+ + A +RKLQ
Sbjct: 1866 EDERKMAEQYKEQAEKGNARVKQLKRQL--------------EEAEEESQRINANRRKLQ 1911
Query: 684 RELRTALDKIEEMEMTNSHLAKRL 707
REL A + E M + L +L
Sbjct: 1912 RELDEATESNEAMGREVNALKSKL 1935
Score = 55.8 bits (133), Expect = 1e-07
Identities = 84/387 (21%), Positives = 154/387 (39%), Gaps = 84/387 (21%)
Query: 353 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE 412
Q+Q++ ++ Q ++EL E L E++K+A A LD K L + L +
Sbjct: 1200 QVQEMRQKHAQAVEELTEQL----EQFKRA---KANLDKNKQTLEKENADLAGELRV--- 1249
Query: 413 QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMT-- 470
+ + +E E K K+LE Q +Q + +G R R EL ++ ++Q +++++T
Sbjct: 1250 -LGQAKQEVEHKKKKLEAQ------VQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302
Query: 471 ------------KEVFDLQETLLWKDKKIGALEKQKEYIAC----LRNERDMLREELADL 514
K+V L L + + +QK ++ L ER+ L+++L +
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362
Query: 515 QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLA 574
E + E+H T N +S Q+ A +E+ EG
Sbjct: 1363 MEAKQNLERH------ISTLNIQLSDSKKK------LQDFASTVEALEEG---------- 1400
Query: 575 GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK 634
K+ +I L Q EE+ + + T L +L + + D RQ+
Sbjct: 1401 --KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ-----QELDDLVVDLDNQRQL---- 1449
Query: 635 FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK-------LQRELR 687
++ LE+ + + + K + D +AE R+ L R L
Sbjct: 1450 ---------VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1500
Query: 688 TALDKIEEMEMTNSHLAKRLEKMKANR 714
AL+ EE+E TN L +E + +++
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSK 1527
Score = 48.5 bits (114), Expect = 2e-05
Identities = 85/415 (20%), Positives = 166/415 (40%), Gaps = 83/415 (20%)
Query: 288 DLSSLDEKSD-------KQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL-IDPDT 339
DL + DE+++ +Q E T A L+ + ++ GD L + D+
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA---LAAAAKKKLEGDLKDLELQADS 1642
Query: 340 SLS----ELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNN 395
++ ++ + L+ Q++D + E + +E KKA A
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-------- 1694
Query: 396 LIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 455
D+++ QE+ A E K +LE+++ EEL L R+ L
Sbjct: 1695 ---------DLMQLQEDLAA---AERARKQADLEKEE--------LAEELASSLSGRNAL 1734
Query: 456 IEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQ 515
+EK+R++ +I + +E+ +++ G +E + + + + L ELA +
Sbjct: 1735 QDEKRRLEARIAQLEEEL----------EEEQGNMEAMSDRVRKATQQAEQLSNELATER 1784
Query: 516 ETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAG 575
T + E + HE + GA+ + LE A L+ ++ + A
Sbjct: 1785 STAQKNESARQQLERQNKELRSKLHE-MEGAVKSKFKSTIAALE-AKIAQLEEQVEQEAR 1842
Query: 576 EKE----ELLSQIRKLK---LQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANR 628
EK+ L + +KLK LQ+E+ER+ Q+ E N
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAE------------------QYKEQAEKGNA 1884
Query: 629 QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQ 683
++ + K +L +AE++ + + +L+ ++ A E+ E + E+ A K KL+
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQREL---DEATESNEAMGREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 67.8 bits (164), Expect = 3e-11
Identities = 73/386 (18%), Positives = 164/386 (42%), Gaps = 42/386 (10%)
Query: 340 SLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQ 399
S +L+D + +++ + R+ + ++ L + E Y K + +L E ++L+
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 400 VDTLKDVIEEQEEQMAEF----YRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 455
+D + ++ E++ +F E SK + + + + K + R +E
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495
Query: 456 IEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQ 515
+E K+ +++ + E+ DL + K + LEK K L + + ++ +L +L+
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR---ALETQMEEMKTQLEELE 1552
Query: 516 ETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAG 575
+ ++ E L + + Q L+ E L R +
Sbjct: 1553 DELQATEDAKLRL-----------------------EVNMQALKGQFERDLQARDEQNEE 1589
Query: 576 EKEELLSQIRKLKLQLEEERQK----CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQIS 631
++ +L Q+ + + +LE+ER++ + GDL L+ +D I+ + +A +Q+
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD-SAIKGREEAIKQLR 1648
Query: 632 EYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALD 691
+ + ++ ++++ S + + TA EN EK L+A+ +LQ +L A
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEI------FATAKEN-EKKAKSLEADLMQLQEDLAAAER 1701
Query: 692 KIEEMEMTNSHLAKRLEKMKANRTAL 717
++ ++ LA+ L + R AL
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNAL 1727
Score = 67.0 bits (162), Expect = 6e-11
Identities = 81/352 (23%), Positives = 152/352 (43%), Gaps = 65/352 (18%)
Query: 365 LKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEK 424
L++ KE + E + K+ ++QL EKN +++EQ + E Y E EE
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKN-----------LLQEQLQAETELYAEAEEM 909
Query: 425 SKELERQKHMCSVLQHKME-ELKEGLRQRDELIEEKQRMQQKI----DTMTKEVFDLQET 479
L +K + H+ME L+E + +L E+++M Q++ + + +E Q+
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
Query: 480 LLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVS 539
L K ++K ++ I + ++ + L +E L+E I D T N
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER-----------ISDLTTNLAEE 1018
Query: 540 HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCS 599
E + ++ + + E L+VRL+K +E+ ++ KLK +LE
Sbjct: 1019 EEKAKNLTKLKNKHESMISE------LEVRLKK----EEKSRQELEKLKRKLE------- 1061
Query: 600 RNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVL 659
G F E D QI+E K +L+K E++ L+ +++RL+ ++
Sbjct: 1062 --------------GDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIA 1104
Query: 660 RYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 711
+ A + ++E + + L E R A +K E+ + L + LE +K
Sbjct: 1105 QKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQK---RDLGEELEALK 1152
Score = 66.6 bits (161), Expect = 8e-11
Identities = 90/392 (22%), Positives = 156/392 (39%), Gaps = 77/392 (19%)
Query: 330 DTSSLIDPDTSLSELRDIYDLKDQIQDVE--GRYMQGLKELKESL-SEVEEKYKKAMVSN 386
D ++ + + L E R I DL + + E + + LK ES+ SE+E + KK S
Sbjct: 992 DQNNKLSKERKLLEER-ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1050
Query: 387 AQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELK 446
+L+ K L + I + + Q+AE + L K EEL+
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ-----------------LAKKEEELQ 1093
Query: 447 EGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDM 506
L + D+ I +K +KI + + DLQE L D + A K ++ L E +
Sbjct: 1094 AALARLDDEIAQKNNALKKIRELEGHISDLQEDL---DSERAARNKAEKQKRDLGEELEA 1150
Query: 507 LREELADL------QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLES 560
L+ EL D Q+ ++ + + ++ SHE + + Q+ AQ +E
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE---AQVQEMRQKHAQAVE- 1206
Query: 561 AGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFI 620
E E L Q ++ K L++ +Q + + DLAG
Sbjct: 1207 ---------------ELTEQLEQFKRAKANLDKNKQTLEKENA---DLAG---------- 1238
Query: 621 EMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKR 680
E++ L +A+Q++ E +LE QV ++ + E+ EL +
Sbjct: 1239 ELR------------VLGQAKQEV---EHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 681 KLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 712
KLQ E+ + + E E LAK + + +
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Score = 64.7 bits (156), Expect = 3e-10
Identities = 78/390 (20%), Positives = 168/390 (43%), Gaps = 20/390 (5%)
Query: 345 RDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNE---KNNLIYQVD 401
+D+ L Q+QD + + ++ +++ + ++ QLD E K NL +
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367
Query: 402 TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQR 461
TL + + ++++ +F E E +K +++ ++ +E D+L + K R
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALE---EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424
Query: 462 MQQKIDTMTKEVFDLQETLLWKDKKIGA----LEKQKEYIACLRNERDMLREELADLQET 517
+QQ++D + ++ + ++ + +KK L ++K + +ERD E + +ET
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE-KET 1483
Query: 518 VKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEK 577
L + + +++ + + + V ++ E L+ R L +
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE--LEKSKRALETQM 1541
Query: 578 EELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGL----QNGSDLQFIEMQRDANRQISEY 633
EE+ +Q+ +L+ +L+ R + + L G D Q E +R RQ+ EY
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 634 KFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI 693
+ +L + + +LEG + + A++A K +E + RKLQ +++ ++
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 694 EEMEMTNSHL---AKRLEKMKANRTALLAQ 720
E+ + + AK EK + A L Q
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Score = 59.7 bits (143), Expect = 9e-09
Identities = 79/336 (23%), Positives = 142/336 (42%), Gaps = 55/336 (16%)
Query: 396 LIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 455
L +V L V ++EE A+ +E K ERQ Q ELKE ++ +L
Sbjct: 837 LFTKVKPLLQVTRQEEEMQAK----EDELQKTKERQ-------QKAENELKELEQKHSQL 885
Query: 456 IEEKQRMQQKIDTMTK---EVFDLQETLLWKDKKI--------GALEKQKEYIACLRNER 504
EEK +Q+++ T+ E +++ L K +++ LE++++ L+ ER
Sbjct: 886 TEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 945
Query: 505 DMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG 564
+ +++ DL+E ++ E + E V + E ++
Sbjct: 946 KKMAQQMLDLEEQLEEEE----------AARQKLQLEKVTAEAKIKKLEDEILV------ 989
Query: 565 PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQ- 623
+D + KL+ E++ L +I L L EE +K +L L+N + E++
Sbjct: 990 -MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK-------NLTKLKNKHESMISELEV 1041
Query: 624 --RDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK 681
+ + E + K E D + + I+ L+ Q+ K K E+EL+A +
Sbjct: 1042 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM---QLAKKEEELQAALAR 1098
Query: 682 LQREL---RTALDKIEEMEMTNSHLAKRLEKMKANR 714
L E+ AL KI E+E S L + L+ +A R
Sbjct: 1099 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Score = 59.3 bits (142), Expect = 1e-08
Identities = 85/384 (22%), Positives = 169/384 (44%), Gaps = 59/384 (15%)
Query: 349 DLKDQIQDVEGRYMQGLKELKESLSEVEEKYKK---AMVSNAQLDNEKNNLIYQVDTLKD 405
DL+ + + E + Q ++L E +E+E++ K+ A + +L+ + +L Q D+
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS--- 1635
Query: 406 VIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQK 465
I+ +EE + + R+ + + K+ +R EL++ RDE+ + ++K
Sbjct: 1636 AIKGREEAIKQL-RKLQAQMKDFQR-------------ELEDARASRDEIFATAKENEKK 1681
Query: 466 IDTMTKEVFDLQETLLWKDKKIGALEKQKEYIA-----------CLRNERDMLREELADL 514
++ ++ LQE L ++ + +KE +A L++E+ L +A L
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 515 QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG------PLDV 568
+E ++ E+ + + D E ++ + + AQ ESA + L
Sbjct: 1742 EEELEE-EQGNMEAMSDRVRKATQQAEQLSNELAT-ERSTAQKNESARQQLERQNKELRS 1799
Query: 569 RLRKLAGE-KEELLSQIRKLKL---QLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR 624
+L ++ G K + S I L+ QLEE+ ++ +R + + Q L+ I +Q
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR-EKQAATKSLKQKDKKLKEILLQV 1858
Query: 625 DANRQISE-YKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQ 683
+ R+++E YK + K + L++ + E AE+ + A +RKLQ
Sbjct: 1859 EDERKMAEQYKEQAEKGNARVKQLKRQL--------------EEAEEESQRINANRRKLQ 1904
Query: 684 RELRTALDKIEEMEMTNSHLAKRL 707
REL A + E M + L +L
Sbjct: 1905 RELDEATESNEAMGREVNALKSKL 1928
Score = 55.8 bits (133), Expect = 1e-07
Identities = 84/387 (21%), Positives = 154/387 (39%), Gaps = 84/387 (21%)
Query: 353 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE 412
Q+Q++ ++ Q ++EL E L E++K+A A LD K L + L +
Sbjct: 1193 QVQEMRQKHAQAVEELTEQL----EQFKRA---KANLDKNKQTLEKENADLAGELRV--- 1242
Query: 413 QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMT-- 470
+ + +E E K K+LE Q +Q + +G R R EL ++ ++Q +++++T
Sbjct: 1243 -LGQAKQEVEHKKKKLEAQ------VQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295
Query: 471 ------------KEVFDLQETLLWKDKKIGALEKQKEYIAC----LRNERDMLREELADL 514
K+V L L + + +QK ++ L ER+ L+++L +
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355
Query: 515 QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLA 574
E + E+H T N +S Q+ A +E+ EG
Sbjct: 1356 MEAKQNLERH------ISTLNIQLSDSKKK------LQDFASTVEALEEG---------- 1393
Query: 575 GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK 634
K+ +I L Q EE+ + + T L +L + + D RQ+
Sbjct: 1394 --KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ-----QELDDLVVDLDNQRQL---- 1442
Query: 635 FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK-------LQRELR 687
++ LE+ + + + K + D +AE R+ L R L
Sbjct: 1443 ---------VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1493
Query: 688 TALDKIEEMEMTNSHLAKRLEKMKANR 714
AL+ EE+E TN L +E + +++
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSK 1520
Score = 48.5 bits (114), Expect = 2e-05
Identities = 85/415 (20%), Positives = 166/415 (40%), Gaps = 83/415 (20%)
Query: 288 DLSSLDEKSD-------KQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL-IDPDT 339
DL + DE+++ +Q E T A L+ + ++ GD L + D+
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA---LAAAAKKKLEGDLKDLELQADS 1635
Query: 340 SLS----ELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNN 395
++ ++ + L+ Q++D + E + +E KKA A
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-------- 1687
Query: 396 LIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 455
D+++ QE+ A E K +LE+++ EEL L R+ L
Sbjct: 1688 ---------DLMQLQEDLAA---AERARKQADLEKEE--------LAEELASSLSGRNAL 1727
Query: 456 IEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQ 515
+EK+R++ +I + +E+ +++ G +E + + + + L ELA +
Sbjct: 1728 QDEKRRLEARIAQLEEEL----------EEEQGNMEAMSDRVRKATQQAEQLSNELATER 1777
Query: 516 ETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAG 575
T + E + HE + GA+ + LE A L+ ++ + A
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHE-MEGAVKSKFKSTIAALE-AKIAQLEEQVEQEAR 1835
Query: 576 EKE----ELLSQIRKLK---LQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANR 628
EK+ L + +KLK LQ+E+ER+ Q+ E N
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAE------------------QYKEQAEKGNA 1877
Query: 629 QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQ 683
++ + K +L +AE++ + + +L+ ++ A E+ E + E+ A K KL+
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQREL---DEATESNEAMGREVNALKSKLR 1929
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 67.4 bits (163), Expect = 4e-11
Identities = 100/486 (20%), Positives = 211/486 (43%), Gaps = 112/486 (23%)
Query: 338 DTSLSEL-RDIYDLKDQIQDVE-----------------------GRYMQG-LKELKESL 372
D+ +S + R + DL+++IQ ++ ++M+ +++LKE L
Sbjct: 388 DSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEEL 447
Query: 373 S----EVEEKYKKAMVSNAQLDNEKNNLI---YQVDTLKDVIEEQEEQMAEFYRENEEKS 425
S + EE KKA A++ K L ++ L+ +E Q ++ + E
Sbjct: 448 SSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLK 507
Query: 426 KELERQKHMCSVLQHKMEELKEGLRQRDELIEEK----QRMQQKIDTMTKEVFDLQETLL 481
+ L ++ ++LQ +++ L+ L +++ ++ +K Q M ++ T E+ DL++ L
Sbjct: 508 ESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLD 567
Query: 482 WKDKKIGALEKQKEYIACLRNERDMLRE---ELADLQETVK------TGEKHGLVIIPDG 532
K++K+ L+K+ + N ++ LR+ +++ L+E VK T L + +
Sbjct: 568 VKERKVNVLQKK------IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEA 621
Query: 533 TPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVR-----LRKLAGEKEELL------ 581
+ + E + +E + +++ + D++ L+ EKE L
Sbjct: 622 LAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEH 681
Query: 582 ------------SQIRKLKLQLEEERQKCSRNDGTV--GDLAGLQNGSDLQFIEMQRDAN 627
S+++ L++ LE+++++C + + + A L+ + + + +
Sbjct: 682 ASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLE 741
Query: 628 RQISEYKFKLSKAEQDITTL--------------EQSISRLEGQV---------LRYKTA 664
R+I+ YK + SKA+ ++ L ++ I+ LE QV L++K
Sbjct: 742 REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQ 801
Query: 665 A---------ENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRT 715
E A + ED L ++LQ LR D+IEE+E + ++ A R
Sbjct: 802 VEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELE----EALRESVQITAERE 857
Query: 716 ALLAQQ 721
+LAQ+
Sbjct: 858 MVLAQE 863
Score = 56.6 bits (135), Expect = 8e-08
Identities = 90/447 (20%), Positives = 187/447 (41%), Gaps = 79/447 (17%)
Query: 338 DTSLSELRD-IYDLKDQIQDVEGRYMQGLKELKESLSEVEEK----YKKAMVSNAQLDNE 392
DT L L+ + L +Q D + Q ++ LKESL+ E++ + +L+ +
Sbjct: 479 DTELLALQTKLETLTNQFSDSK----QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK 534
Query: 393 KNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 452
+ L + ++D+ EE+ Q E + + L+ ++ +VLQ K+E L+E LR +
Sbjct: 535 ETMLNKKTKQIQDMAEEKGTQAGEIH----DLKDMLDVKERKVNVLQKKIENLQEQLRDK 590
Query: 453 DE----LIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNER-DML 507
++ L E + +Q + L+E L K++ I L++Q++ + E D
Sbjct: 591 EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNY 650
Query: 508 REELADLQETVKTGE--------------KHGLVIIPDGTPNGDVSHEPVAGAITVVSQE 553
+++L DL+E V + +H + G D + + A+ +E
Sbjct: 651 KKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKK-DSRLKTLEIALEQKKEE 709
Query: 554 AAQV---LESAGEGPLDVRLR-KLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 609
++ L+ A E L+ R +++ + L +I + K + + + + R + ++
Sbjct: 710 CLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVE 769
Query: 610 GLQNGSDLQFIEMQR---DANRQISEYKFK------------------------------ 636
+N D + E++R D N++++ K K
Sbjct: 770 NEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQ 829
Query: 637 --LSKAEQDITTLEQSI-------SRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELR 687
L K + I LE+++ + E + + ++A NAEK +EL K+++EL
Sbjct: 830 DSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELE 889
Query: 688 TALDKIEEMEMTNSHLAKRLEKMKANR 714
+ K+ + + + L ++A R
Sbjct: 890 SMKAKLSSTQQSLAEKETHLTNLRAER 916
Score = 51.6 bits (122), Expect = 3e-06
Identities = 66/359 (18%), Positives = 140/359 (38%), Gaps = 32/359 (8%)
Query: 381 KAMVSNAQLDNEKNNLIYQVDTLKD----VIEEQEEQMAEFYRENEEKSKELERQKHMCS 436
+A+ ++ + N L Q + + V E EE + E+E ++KEL +
Sbjct: 230 QALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLE 289
Query: 437 VLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEY 496
++ ++E K+ L RDE I++ M Q K + E + +++ E +
Sbjct: 290 EMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHE----RTRRLAEAEMHVHH 345
Query: 497 IACL----RNERDMLREEL----ADLQETVKTGEKHGLVIIPDGTPNG-DVSHEPVAGAI 547
+ L E MLREE+ + ++ KT ++ + D + + + I
Sbjct: 346 LESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEI 405
Query: 548 TVVSQEAAQVLESAGEGPLDVRLRK-----LAGEKEELLSQIRKLKLQLEEERQKCSRND 602
++ A E E + + + + + E+L ++ + Q EE ++K +
Sbjct: 406 QMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQ 465
Query: 603 GTVGDLAGLQNGSDLQFIEMQ----------RDANRQISEYKFKLSKAEQDITTLEQSIS 652
+G + + D + + +Q D+ + I K L+ EQ L+ +
Sbjct: 466 AEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVD 525
Query: 653 RLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 711
L ++ +T K ++ EK E+ D ++ E + L K++E ++
Sbjct: 526 ALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQ 584
Score = 48.1 bits (113), Expect = 3e-05
Identities = 73/394 (18%), Positives = 165/394 (41%), Gaps = 66/394 (16%)
Query: 343 ELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDT 402
E R ++ D+IQ +E + + K+ S+ + + + + +++NEKN
Sbjct: 726 EARASPEMSDRIQHLE----REITRYKDESSKAQAEVDRLLEILKEVENEKN-------- 773
Query: 403 LKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEE-LKEGLRQRDELIEEKQR 461
++++++AE R+ ++++K++ KH V + K + L+E R+ D L + Q+
Sbjct: 774 ------DKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQ 827
Query: 462 MQQKIDTMTKEVFDLQE--------------TLLWKDKKIGALEKQKEYIAC----LRNE 503
+Q + + +L+E L ++ EKQ E + ++ E
Sbjct: 828 LQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQE 887
Query: 504 RDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGE 563
+ ++ +L+ Q+++ E H N + + QEA +L + E
Sbjct: 888 LESMKAKLSSTQQSLAEKETH--------LTNLRAERRKHLEEVLEMKQEA--LLAAISE 937
Query: 564 GPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQ 623
++ L +L+ K++ ++ LK + + Q+ + L N D F
Sbjct: 938 KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMA-DNYEDDHF---- 992
Query: 624 RDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAE-------------K 670
+ ++ + +K + Q + L+Q+ S+L+ + T + +
Sbjct: 993 KSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYN 1052
Query: 671 VEDELKAEKRKLQRELRTAL-DKIEEMEMTNSHL 703
++D+ A + +LQ+ R L D++E+ E N+ L
Sbjct: 1053 LDDDQAAWENELQKMTRGQLQDELEKGERDNAEL 1086
Score = 34.7 bits (78), Expect = 0.32
Identities = 78/372 (20%), Positives = 141/372 (37%), Gaps = 79/372 (21%)
Query: 367 ELKESLSEVEEKYKKAMVSNAQLDNEKNNL-IYQVDTLKDVIEEQEEQMAEFYRENEEKS 425
+LKE L E + K V ++L + N++ + LK ++++ ++ E+
Sbjct: 157 QLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYR 216
Query: 426 KELERQKHMCSVLQHKMEELK-----EGLRQRD-----------ELIEEK-QRMQQKIDT 468
E +HM +Q +EL+ L Q+D EL EE QR+ + +
Sbjct: 217 VVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHER 276
Query: 469 MTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVI 528
KE+F L++TL + +I E QK+ + N RD ++L ++ ++
Sbjct: 277 QAKELFLLRKTLEEMELRI---ETQKQTL----NARDESIKKLLEMLQS----------- 318
Query: 529 IPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLK 588
G ++E + E + V E LL Q K
Sbjct: 319 ---------------KGLSAKATEEDHERTRRLAEAEMHVH------HLESLLEQKEKEN 357
Query: 589 LQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLE 648
L EE + N LQ IEM+ K+S E+ + LE
Sbjct: 358 SMLREEMHRRFENAPDSAKTKALQT-----VIEMKDS----------KISSMERGLRDLE 402
Query: 649 QSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLE 708
+ I L+ A + E+ E+E+K + + + +K+E+++ S + E
Sbjct: 403 EEIQMLK------SNGALSTEEREEEMK-QMEVYRSHSKFMKNKVEQLKEELSSKEAQWE 455
Query: 709 KMKANRTALLAQ 720
++K L A+
Sbjct: 456 ELKKKAAGLQAE 467
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 67.0 bits (162), Expect = 6e-11
Identities = 96/403 (23%), Positives = 180/403 (44%), Gaps = 69/403 (17%)
Query: 350 LKDQIQDVEGRYMQ---GLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDV 406
L+ +I+D + MQ +KEL+ + E+EE+ + S A+ + ++++L +++ + +
Sbjct: 1094 LQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1153
Query: 407 IEEQEEQMAEFYRENEEKSKELERQKHMC--SVLQHK----------MEELKEGLRQRDE 454
+EE + N+++ E ++ + + LQH+ + + E Q D
Sbjct: 1154 LEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1213
Query: 455 LIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADL 514
L KQ+++++ M E+ DL + K G LEK + L D
Sbjct: 1214 LQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEK--------------MCRALEDQ 1259
Query: 515 QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLA 574
+KT E+ +I D T + S E ++ L+ D + +L+
Sbjct: 1260 LSEIKTKEEEQQRLINDLTAQ--------RARLQTESGEYSRQLDEK-----DTLVSQLS 1306
Query: 575 GEKEELLSQIRKLKLQLEEERQ---------KCSRNDGTVGDLAGLQNGSDLQF-IEMQR 624
K+ QI +LK QLEEE + + SR+D DL Q + + E+QR
Sbjct: 1307 RGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHD---CDLLREQYEEEQEAKAELQR 1363
Query: 625 ---DANRQISEYKFKL-SKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDE---LKA 677
AN ++++++ K + A Q LE++ +L R + A E+ E V + L+
Sbjct: 1364 AMSKANSEVAQWRTKYETDAIQRTEELEEAKKKL---AQRLQDAEEHVEAVNAKCASLEK 1420
Query: 678 EKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 720
K++LQ E+ D + ++E TN+ A L+K + N +LA+
Sbjct: 1421 TKQRLQNEVE---DLMIDVERTNAACA-ALDKKQRNFDKILAE 1459
Score = 64.3 bits (155), Expect = 4e-10
Identities = 87/455 (19%), Positives = 184/455 (40%), Gaps = 51/455 (11%)
Query: 289 LSSLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDP----DTSLSEL 344
+ L+E+ + + A R+ S G TS+ I+ + ++
Sbjct: 1119 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1178
Query: 345 RDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK 404
R DL++ E K+ +S++E+ E+ +L+ EK+ + ++D L
Sbjct: 1179 RR--DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1236
Query: 405 DVIEEQ--------------EEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLR 450
+E E+Q++E + EE+ + + + LQ + E L
Sbjct: 1237 SNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLD 1296
Query: 451 QRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREE 510
++D L+ + R +Q T+++ +L+ L +++I A + R++ D+LRE+
Sbjct: 1297 EKDTLVSQLSRGKQ---AFTQQIEELKRQL---EEEIKAKSALAHALQSSRHDCDLLREQ 1350
Query: 511 LADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA----AQVLESAGEG-- 564
+ QE K + + +E A T +EA AQ L+ A E
Sbjct: 1351 YEEEQEA-KAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVE 1409
Query: 565 PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR 624
++ + L K+ L +++ L + +E C+ D + QR
Sbjct: 1410 AVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALD------------------KKQR 1451
Query: 625 DANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQR 684
+ ++ ++E+K K + ++ ++ L ++ + K A E + + LK E + LQ+
Sbjct: 1452 NFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQ 1511
Query: 685 ELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLA 719
E+ ++I E L K ++++ ++ L A
Sbjct: 1512 EISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQA 1546
Score = 63.9 bits (154), Expect = 5e-10
Identities = 90/382 (23%), Positives = 163/382 (42%), Gaps = 58/382 (15%)
Query: 366 KELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKS 425
++ KE L++ E K K+ L EKN+L QV D + + EE+ + + +
Sbjct: 861 EKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQ-- 918
Query: 426 KELERQKHMCSVLQHKMEELKEGLRQRD----ELIEEKQRMQQKIDTMTKEVFDLQETLL 481
L+ K++E+ E + EL +K++++ + + K++ DL+ TL
Sbjct: 919 ------------LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL- 965
Query: 482 WKDKKIGALEKQKEYIACLRNERDMLREELADLQETVK--TGEKHGLVIIPDGTPNGDVS 539
+EK+K N+ L EE+A L ET+ T EK L T + +
Sbjct: 966 ------AKVEKEKH---ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA 1016
Query: 540 HEPVAGAIT---VVSQEAAQVLESAGEGPLDVRL------RKLAGE---KEELLSQIRKL 587
E +T + ++ LE + E +R+ RKL G+ +E I
Sbjct: 1017 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIEND 1076
Query: 588 KLQLEEERQKCSRNDGTVGDLAGLQNG-SDLQFIEMQRDANRQISEYKFKLSKAEQDITT 646
K QL+E+ +K +++GLQ+ D Q + MQ ++I E + ++ + E++I
Sbjct: 1077 KQQLDEKLKK------KEFEMSGLQSKIEDEQALGMQ--LQKKIKELQARIEELEEEIEA 1128
Query: 647 LEQSISRLEGQVLRYKTAAEN-AEKVEDELKAE------KRKLQRELRTALDKIEEMEMT 699
S ++ E Q E +E++E+ A +K + E + +EE +
Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188
Query: 700 NSHLAKRLEKMKANRTALLAQQ 721
+ A L K A+ A L +Q
Sbjct: 1189 HEATAATLRKKHADSVAELGEQ 1210
Score = 57.4 bits (137), Expect = 5e-08
Identities = 79/377 (20%), Positives = 159/377 (42%), Gaps = 42/377 (11%)
Query: 344 LRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL 403
L D + DQ+ + + +KE+ E + EE NA+L +K L + L
Sbjct: 902 LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEE-------INAELTAKKRKLEDECSEL 954
Query: 404 KDVIEEQEEQMAEFYRE---NEEKSKELERQKHMCSVLQHKMEELKEGLRQ-RDELIEEK 459
K I++ E +A+ +E E K K L + K+ + K+ L++ + +++
Sbjct: 955 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1014
Query: 460 QRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQETVK 519
Q + K++T+TK L++ + D G+LE++K+ L + L +L QE+
Sbjct: 1015 QAEEDKVNTLTKAKIKLEQQV---DDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTM 1071
Query: 520 TGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEE 579
E + ++G + + E A ++ L ++++L EE
Sbjct: 1072 DIENDKQQL----DEKLKKKEFEMSGLQSKIEDEQALGMQ------LQKKIKELQARIEE 1121
Query: 580 LLSQI---RKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFK 636
L +I R + + E++R SR + + G+ IEM + + + +
Sbjct: 1122 LEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD 1181
Query: 637 LSKA----EQDITTLEQ----SISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRT 688
L +A E TL + S++ L Q+ +N ++V+ +L+ EK +++ E+
Sbjct: 1182 LEEATLQHEATAATLRKKHADSVAELGEQI-------DNLQRVKQKLEKEKSEMKMEIDD 1234
Query: 689 ALDKIEEMEMTNSHLAK 705
+E + +L K
Sbjct: 1235 LASNMETVSKAKGNLEK 1251
Score = 45.8 bits (107), Expect = 1e-04
Identities = 74/359 (20%), Positives = 156/359 (43%), Gaps = 49/359 (13%)
Query: 366 KELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKS 425
+ L L +++ Y++++ L E NL ++ L + I E +++ E E+
Sbjct: 1479 RSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL----EKIK 1534
Query: 426 KELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDK 485
K++E++K S LQ +EE + L + I R+Q +++ + EV + KD+
Sbjct: 1535 KQVEQEK---SELQAALEEAEASLEHEEGKI---LRIQLELNQVKSEV---DRKIAEKDE 1585
Query: 486 KIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNG---DVSHEP 542
+I +++ +I + + + L E+ + ++ +K +G N ++H
Sbjct: 1586 EIDQMKRN--HIRIVESMQSTLDAEIRSRNDAIRLKKKM------EGDLNEMEIQLNHAN 1637
Query: 543 VAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRK---LKLQLEEERQKCS 599
A + + Q + + LD LR KE+L R+ L+ ++EE R
Sbjct: 1638 RMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLE 1697
Query: 600 RNDGT--VGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQ 657
+ + + + + L +Q + Q N + K KL E IS+++G+
Sbjct: 1698 QTERSRKIAEQELLDASERVQLLHTQ---NTSLINTKKKL----------ETDISQIQGE 1744
Query: 658 VLRYKTAAENAEK------VEDELKAEKRKLQRELRTALDKIEE-MEMTNSHLAKRLEK 709
+ A NAE+ + + AE+ K +++ L+++++ +E T L RL++
Sbjct: 1745 MEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE 1803
Score = 41.2 bits (95), Expect = 0.003
Identities = 31/132 (23%), Positives = 68/132 (51%), Gaps = 14/132 (10%)
Query: 579 ELLSQIRKLKLQLEEERQKCSRNDGTVGDLAG-----LQNGSDLQFIEMQRDANRQISEY 633
E ++ +K + E+ +++ ++ + +L +Q +DLQ +++Q +A+
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQ-LQVQAEAD------ 900
Query: 634 KFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI 693
L+ AE+ L ++ +LE ++ AE+ E++ EL A+KRKL+ E I
Sbjct: 901 --SLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 958
Query: 694 EEMEMTNSHLAK 705
+++E+T + + K
Sbjct: 959 DDLELTLAKVEK 970
Score = 40.8 bits (94), Expect = 0.004
Identities = 64/336 (19%), Positives = 140/336 (41%), Gaps = 35/336 (10%)
Query: 366 KELKESLSEVEEKYKKAMVSNAQ-LDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEK 424
K+++ L+E+E + A A+ L N +N + ++++ + + + R E+
Sbjct: 1620 KKMEGDLNEMEIQLNHANRMAAEALRNYRNT--------QAILKDTQLHLDDALRSQEDL 1671
Query: 425 SKELERQKHMCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTK-EVFDLQETLLWK 483
++L + ++LQ ++EEL+ L Q + K Q+ +D + ++ Q T L
Sbjct: 1672 KEQLAMVERRANLLQAEIEELRATLEQTER--SRKIAEQELLDASERVQLLHTQNTSLIN 1729
Query: 484 DKKIGALEKQKEYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSH--- 540
KK K + I+ ++ E + + +E + +E K ++ + D S
Sbjct: 1730 TKK-----KLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1784
Query: 541 ------EPVAGAITVVSQEAAQVLESAGEGP---LDVRLRKLAGEKE-ELLSQIRKLKLQ 590
E + EA Q+ G+ L+ R+R+L GE E E + +K
Sbjct: 1785 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGL 1844
Query: 591 LEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQS 650
+ ER+ T D + L+ ++ ++ YK + +AE+
Sbjct: 1845 RKHERKVKELTYQTEEDRKNI-----LRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSK 1899
Query: 651 ISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQREL 686
R++ ++ + A+ AE ++L+ + R++ ++
Sbjct: 1900 FRRIQHELEEAEERADIAESQVNKLRVKSREVHTKI 1935
Score = 35.8 bits (81), Expect = 0.14
Identities = 19/103 (18%), Positives = 52/103 (50%), Gaps = 4/103 (3%)
Query: 345 RDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK 404
+ I L+ +++++EG K E++ + + +K Q + ++ N++ L+
Sbjct: 1814 KQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNIL----RLQ 1869
Query: 405 DVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKE 447
D++++ + ++ + R+ EE ++ +QH++EE +E
Sbjct: 1870 DLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEE 1912
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 67.0 bits (162), Expect = 6e-11
Identities = 97/508 (19%), Positives = 201/508 (39%), Gaps = 62/508 (12%)
Query: 254 SRGRRESVVSAADYFSRSNRRGSVVSEVDDISIPDLSSLDEKSDKQYAENYTRPSSRNSA 313
SR R+ Y SN + + + + SL++ D+ ++ R S S
Sbjct: 52 SRNLRQVDQMLGRYREYSNGQAGAIEHLKE-------SLEQSIDQLRSQRLLRNSGGRSI 104
Query: 314 SATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLS 373
S T+ LS + G+G P + L + D +K R++Q ++ + L
Sbjct: 105 SVTS-LSASDLDGGTGSELHHFPPTSPLKDYGDPQGIKRMRSRTGVRFVQETDDMTQ-LH 162
Query: 374 EVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKH 433
+ + +L ++ N + + + + E EK E ++Q+
Sbjct: 163 GFHQSLRDLSSEQIRLGDDFNRELSRRS-------RSDAETKRALEELTEKLNEAQKQEV 215
Query: 434 MCSVLQHKMEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQ 493
+ ++ +++EL+ +R EL+E +Q + +E QE D+ GA++ +
Sbjct: 216 VSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKA--DEHEGAIKNK 273
Query: 494 KEYIACLRNERDM---LREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVV 550
+N+ + L L + E + H + + + + + ++ +
Sbjct: 274 LRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQI 333
Query: 551 SQEAAQVLESAGEGPLDVRLRK-LAGEKEELLSQIRKLKLQLE--------EERQKC-SR 600
S++ + + GE D R R+ + EK++L Q+ L++QL EE ++C R
Sbjct: 334 SKQQSNYQDEQGE---DWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMER 390
Query: 601 NDGTVGDLAG--------LQNGS--DLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQS 650
D LA L+NG LQ ++ ++ + + A+ I+ L +
Sbjct: 391 KDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRH 450
Query: 651 ISRLEGQVLRYKTAAENAEKVEDE---------LKAEK---------RKLQRELRTALDK 692
Q RY + + +E +++E LKA++ +KL+R L +
Sbjct: 451 AEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSET 510
Query: 693 IEEMEMTNSHLAKRLEKMKANRTALLAQ 720
++E+ N+ + K +++K A L Q
Sbjct: 511 VDELTGKNNQILKEKDELKTQLYAALQQ 538
Score = 60.8 bits (146), Expect = 4e-09
Identities = 97/453 (21%), Positives = 196/453 (43%), Gaps = 51/453 (11%)
Query: 294 EKSDKQYA------ENYTRPSSRNSASATTPLSGNSSRRGSGDT--SSLIDPDTSLSEL- 344
E+ DK+ A EN TR L + DT + D +SEL
Sbjct: 389 ERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELT 448
Query: 345 RDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK 404
R D Q + RY+ L++ E+L E EK ++ + AQ + L ++ L+
Sbjct: 449 RHAEDATKQAE----RYLSELQQ-SEALKEEAEKRREDLKLKAQESIRQWKLKHK--KLE 501
Query: 405 DVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLR--------QRDELI 456
+E+Q E + E +N + KE + K ++E L++ L Q +EL
Sbjct: 502 RALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELH 561
Query: 457 EEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADLQE 516
++++++ +++ +L + L+KQ + + ++ E+ L EE+A+L++
Sbjct: 562 SKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKK 621
Query: 517 TVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGE 576
+ + +K L+ + + + +A + + VL+ + + R
Sbjct: 622 S-QAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRD---- 676
Query: 577 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQ--ISEYK 634
EE + I +LKL+ + +++ DL S LQ ++ + + N Q + +K
Sbjct: 677 -EETATIITQLKLERDVHQRELK-------DLT-----SSLQSVKTKHEQNIQELMKHFK 723
Query: 635 FKLSKAEQDITTL------EQSISRLE-GQVLRYKTAAENAEKVEDELKAEKRKLQRELR 687
+ S+AE I TL E++++++ GQ+ + K+ + + + + E +KL+ + +
Sbjct: 724 KEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQ 783
Query: 688 TALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 720
D++EE E S + L +M+ R L Q
Sbjct: 784 CLKDQLEEREKHISIEEEHLRRMEEARLQLKDQ 816
Score = 59.7 bits (143), Expect = 9e-09
Identities = 106/491 (21%), Positives = 199/491 (40%), Gaps = 65/491 (13%)
Query: 270 RSNRRGSVVSEVDDI--------SIPDLSSLDEKSDKQYAENYTRPSSRNSASATTPLSG 321
RS V E DD+ S+ DLSS + + +R SR+ A L
Sbjct: 144 RSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSR-RSRSDAETKRALEE 202
Query: 322 NSSRRGSGDTSSLIDPDTSLS------ELRDIYDLKDQIQDVEGRYMQGLKE-LKESLSE 374
+ + ++ E+R +L ++ QD G L+E LK+ ++
Sbjct: 203 LTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAK 262
Query: 375 VEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHM 434
+E Q + EKN L +++ + ++ + E + EE +L + +
Sbjct: 263 ADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGD 322
Query: 435 CSVLQHKMEELK-----------EGLRQRDELIEEKQ---------RMQQKIDTMTKEVF 474
LQH++ ++ E R R + EKQ R+Q M E+
Sbjct: 323 RKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELE 382
Query: 475 DLQETLLWKDKKIGALEKQKEYIAC-LRN-ERDMLR--EELADLQ---ETVKTGEKHGLV 527
+++ + KDK+ L Q E + L N E+ L+ + L ++Q +T + KH +
Sbjct: 383 EVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADL 442
Query: 528 IIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKL 587
I + T + + + + ++ + Q A + E A + D++L+ IR+
Sbjct: 443 QISELTRHAEDATKQAERYLSELQQSEA-LKEEAEKRREDLKLKAQ--------ESIRQW 493
Query: 588 KLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTL 647
KL+ ++ + + TV +L G N I ++D E K +L A Q I L
Sbjct: 494 KLKHKKLERALEKQSETVDELTGKNNQ-----ILKEKD------ELKTQLYAALQQIENL 542
Query: 648 EQSISR-LEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKR 706
+ ++ L + L+ + EK+ D +K+ + L+ E++ +LD I +E +K
Sbjct: 543 RKELNDVLTKRALQEEELHSKEEKLRD-IKSHQADLELEVKNSLDTIHRLESELKKQSKI 601
Query: 707 LEKMKANRTAL 717
+MK + L
Sbjct: 602 QSQMKVEKAHL 612
Score = 44.7 bits (104), Expect = 3e-04
Identities = 97/444 (21%), Positives = 181/444 (40%), Gaps = 85/444 (19%)
Query: 285 SIPDLSSLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGD--TSSLIDPDTSLS 342
SI DLS++ + AE R + LS +++ S D T+++I T L
Sbjct: 636 SIKDLSAIRADLANKLAEE-----ERAKKAVLKDLSDLTAQAKSRDEETATII---TQLK 687
Query: 343 ELRDIY-----DLKDQIQDVEGRYMQGLKEL----KESLSEVEEKYKKAMVSNAQLDNEK 393
RD++ DL +Q V+ ++ Q ++EL K+ SE E + + + N
Sbjct: 688 LERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMA 747
Query: 394 NNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKEL----------ERQKHMCSVLQH--K 441
Q++ LK + E++ + ENE K +L ER+KH+ +H +
Sbjct: 748 KIHRGQLEKLKSQCDRLTEELTQ--NENENKKLKLKYQCLKDQLEEREKHISIEEEHLRR 805
Query: 442 MEELKEGLRQRDELIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQK------- 494
MEE + L+ +D+L+ + + + + KE+ D KD ++EK K
Sbjct: 806 MEEAR--LQLKDQLLCLETEQESILGVIGKEI-DAACKTFSKD----SVEKLKVFSSGPD 858
Query: 495 ------EYIACLRNERDMLREELADLQETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAIT 548
++A + + L EEL + +E + +H L++ N +T
Sbjct: 859 IHYDPHRWLAESKTKLQWLCEELKE-RENREKNLRHQLMLCRQQLRN-----------LT 906
Query: 549 VVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGD- 607
+ Q L E +E+LL +I + K L EE Q+ G++ D
Sbjct: 907 ENKESELQCLFQQIE------------RQEQLLDEIHREKRDLLEETQRKDEEMGSLQDR 954
Query: 608 LAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAEN 667
+ L+ + ++ D + E K L + +D S R +G+ +Y+ +
Sbjct: 955 VIALETST-----QVALDHLESVPE-KLSLLEDFKDFRDSCSSSERTDGRYSKYRVRRNS 1008
Query: 668 AEKVEDELKAEKRKLQRELRTALD 691
+ +D+ K + + + RT L+
Sbjct: 1009 LQHHQDDTKYRTKSFKGD-RTFLE 1031
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.335
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,152,785
Number of Sequences: 37866
Number of extensions: 1155586
Number of successful extensions: 15871
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 317
Number of HSP's successfully gapped in prelim test: 997
Number of HSP's that attempted gapping in prelim test: 7189
Number of HSP's gapped (non-prelim): 5532
length of query: 721
length of database: 18,247,518
effective HSP length: 110
effective length of query: 611
effective length of database: 14,082,258
effective search space: 8604259638
effective search space used: 8604259638
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.