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Search of human proteins with 54292123
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54292123 lysosomal trafficking regulator [Homo sapiens]
(3801 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54292123 lysosomal trafficking regulator [Homo sapiens] 7599 0.0
gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Ho... 413 e-114
gi|191252801 WDFY family member 4 [Homo sapiens] 380 e-104
gi|224451124 neurobeachin-like 1 isoform 3 [Homo sapiens] 324 9e-88
gi|149944613 neurobeachin-like 1 isoform 1 [Homo sapiens] 324 9e-88
gi|62422577 neurobeachin [Homo sapiens] 314 9e-85
gi|154240744 neurobeachin-like 1 isoform 2 [Homo sapiens] 305 4e-82
gi|149944548 neurobeachin-like 2 [Homo sapiens] 293 2e-78
gi|148233596 LPS-responsive vesicle trafficking, beach and ancho... 267 1e-70
gi|31543297 neutral sphingomyelinase (N-SMase) activation associ... 252 4e-66
gi|221625547 neutral sphingomyelinase (N-SMase) activation assoc... 252 4e-66
gi|239756689 PREDICTED: WD repeat domain 81 [Homo sapiens] 69 9e-11
gi|239751186 PREDICTED: WD repeat domain 81 [Homo sapiens] 69 9e-11
gi|239745674 PREDICTED: WD repeat domain 81 [Homo sapiens] 69 9e-11
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 62 1e-08
gi|21071067 TBP-associated factor 5 [Homo sapiens] 59 7e-08
gi|32189425 WD repeat domain 69 [Homo sapiens] 59 9e-08
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 53 5e-06
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 53 7e-06
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 53 7e-06
gi|113865883 WD repeat domain 38 [Homo sapiens] 52 1e-05
gi|209969680 Fzr1 protein isoform 1 [Homo sapiens] 51 3e-05
gi|209969678 Fzr1 protein isoform 3 [Homo sapiens] 51 3e-05
gi|33620742 Fzr1 protein isoform 2 [Homo sapiens] 51 3e-05
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 50 3e-05
gi|23199987 WD repeat domain 5B [Homo sapiens] 50 4e-05
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 50 6e-05
gi|18874090 WD repeat domain 48 [Homo sapiens] 50 6e-05
gi|16554629 WD repeat domain 5 [Homo sapiens] 48 2e-04
gi|16554627 WD repeat domain 5 [Homo sapiens] 48 2e-04
>gi|54292123 lysosomal trafficking regulator [Homo sapiens]
Length = 3801
Score = 7599 bits (19716), Expect = 0.0
Identities = 3801/3801 (100%), Positives = 3801/3801 (100%)
Query: 1 MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNS 60
MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNS
Sbjct: 1 MSTDSNSLAREFLTDVNRLCNAVVQRVEAREEEEEETHMATLGQYLVHGRGFLLLTKLNS 60
Query: 61 IIDQALTCREELLTLLLSLLPLVWKIPVQEEKATDFNLPLSADIILTKEKNSSSQRSTQE 120
IIDQALTCREELLTLLLSLLPLVWKIPVQEEKATDFNLPLSADIILTKEKNSSSQRSTQE
Sbjct: 61 IIDQALTCREELLTLLLSLLPLVWKIPVQEEKATDFNLPLSADIILTKEKNSSSQRSTQE 120
Query: 121 KLHLEGSALSSQVSAKVNVFRKSRRQRKITHRYSVRDARKTQLSTSDSEANSDEKGIAMN 180
KLHLEGSALSSQVSAKVNVFRKSRRQRKITHRYSVRDARKTQLSTSDSEANSDEKGIAMN
Sbjct: 121 KLHLEGSALSSQVSAKVNVFRKSRRQRKITHRYSVRDARKTQLSTSDSEANSDEKGIAMN 180
Query: 181 KHRRPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPPDAMALENSREIIPRQGSNTDILSE 240
KHRRPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPPDAMALENSREIIPRQGSNTDILSE
Sbjct: 181 KHRRPHLLHHFLTSFPKQDHPKAKLDRLATKEQTPPDAMALENSREIIPRQGSNTDILSE 240
Query: 241 PAALSVISNMNNSPFDLCHVLLSLLEKVCKFDVTLNHNSPLAASVVPTLTEFLAGFGDCC 300
PAALSVISNMNNSPFDLCHVLLSLLEKVCKFDVTLNHNSPLAASVVPTLTEFLAGFGDCC
Sbjct: 241 PAALSVISNMNNSPFDLCHVLLSLLEKVCKFDVTLNHNSPLAASVVPTLTEFLAGFGDCC 300
Query: 301 SLSDNLESRVVSAGWTEEPVALIQRMLFRTVLHLLSVDVSTAEMMPENLRKNLTELLRAA 360
SLSDNLESRVVSAGWTEEPVALIQRMLFRTVLHLLSVDVSTAEMMPENLRKNLTELLRAA
Sbjct: 301 SLSDNLESRVVSAGWTEEPVALIQRMLFRTVLHLLSVDVSTAEMMPENLRKNLTELLRAA 360
Query: 361 LKIRICLEKQPDPFAPRQKKTLQEVQEDFVFSKYRHRALLLPELLEGVLQILICCLQSAA 420
LKIRICLEKQPDPFAPRQKKTLQEVQEDFVFSKYRHRALLLPELLEGVLQILICCLQSAA
Sbjct: 361 LKIRICLEKQPDPFAPRQKKTLQEVQEDFVFSKYRHRALLLPELLEGVLQILICCLQSAA 420
Query: 421 SNPFYFSQAMDLVQEFIQHHGFNLFETAVLQMEWLVLRDGVPPEASEHLKALINSVMKIM 480
SNPFYFSQAMDLVQEFIQHHGFNLFETAVLQMEWLVLRDGVPPEASEHLKALINSVMKIM
Sbjct: 421 SNPFYFSQAMDLVQEFIQHHGFNLFETAVLQMEWLVLRDGVPPEASEHLKALINSVMKIM 480
Query: 481 STVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGD 540
STVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGD
Sbjct: 481 STVKKVKSEQLHHSMCTRKRHRRCEYSHFMHHHRDLSGLLVSAFKNQVSKNPFEETADGD 540
Query: 541 VYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVHNIGICCCMDPKSVIIPLLHAFK 600
VYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVHNIGICCCMDPKSVIIPLLHAFK
Sbjct: 541 VYYPERCCCIAVCAHQCLRLLQQASLSSTCVQILSGVHNIGICCCMDPKSVIIPLLHAFK 600
Query: 601 LPALKNFQQHILNILNKLILDQLGGAEISPKIKKAACNICTVDSDQLAQLEETLQGNLCD 660
LPALKNFQQHILNILNKLILDQLGGAEISPKIKKAACNICTVDSDQLAQLEETLQGNLCD
Sbjct: 601 LPALKNFQQHILNILNKLILDQLGGAEISPKIKKAACNICTVDSDQLAQLEETLQGNLCD 660
Query: 661 AELSSSLSSPSYRFQGILPSSGSEDLLWKWDALKAYQNFVFEEDRLHSIQIANHICNLIQ 720
AELSSSLSSPSYRFQGILPSSGSEDLLWKWDALKAYQNFVFEEDRLHSIQIANHICNLIQ
Sbjct: 661 AELSSSLSSPSYRFQGILPSSGSEDLLWKWDALKAYQNFVFEEDRLHSIQIANHICNLIQ 720
Query: 721 KGNIVVQWKLYNYIFNPVLQRGVELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQIYVKT 780
KGNIVVQWKLYNYIFNPVLQRGVELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQIYVKT
Sbjct: 721 KGNIVVQWKLYNYIFNPVLQRGVELAHHCQHLSVTSAQSHVCSHHNQCLPQDVLQIYVKT 780
Query: 781 LPILLKSRVIRDLFLSCNGVSQIIELNCLNGIRSHSLKAFETLIISLGEQQKDASVPDID 840
LPILLKSRVIRDLFLSCNGVSQIIELNCLNGIRSHSLKAFETLIISLGEQQKDASVPDID
Sbjct: 781 LPILLKSRVIRDLFLSCNGVSQIIELNCLNGIRSHSLKAFETLIISLGEQQKDASVPDID 840
Query: 841 GIDIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYPKRRKTVNQDVHINTINL 900
GIDIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYPKRRKTVNQDVHINTINL
Sbjct: 841 GIDIEQKELSSVHVGTSFHHQQAYSDSPQSLSKFYAGLKEAYPKRRKTVNQDVHINTINL 900
Query: 901 FLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLSHMLPCISLESLVLPSPEHMHQA 960
FLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLSHMLPCISLESLVLPSPEHMHQA
Sbjct: 901 FLCVAFLCVSKEAESDRESANDSEDTSGYDSTASEPLSHMLPCISLESLVLPSPEHMHQA 960
Query: 961 ADIWSMCRWIYMLSSVFQKQFYRLGGFRVCHKLIFMIIQKLFRSHKEEQGKKEGDTSVNE 1020
ADIWSMCRWIYMLSSVFQKQFYRLGGFRVCHKLIFMIIQKLFRSHKEEQGKKEGDTSVNE
Sbjct: 961 ADIWSMCRWIYMLSSVFQKQFYRLGGFRVCHKLIFMIIQKLFRSHKEEQGKKEGDTSVNE 1020
Query: 1021 NQDLNRISQPKRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVSA 1080
NQDLNRISQPKRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVSA
Sbjct: 1021 NQDLNRISQPKRTMKEDLLSLAIKSDPIPSELGSLKKSADSLGKLELQHISSINVEEVSA 1080
Query: 1081 TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILF 1140
TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILF
Sbjct: 1081 TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILF 1140
Query: 1141 EMRDHLSQSKVIETQLAKPLFDALLRVALGNYSADFEHNDAMTEKSHQSAEELSSQPGDF 1200
EMRDHLSQSKVIETQLAKPLFDALLRVALGNYSADFEHNDAMTEKSHQSAEELSSQPGDF
Sbjct: 1141 EMRDHLSQSKVIETQLAKPLFDALLRVALGNYSADFEHNDAMTEKSHQSAEELSSQPGDF 1200
Query: 1201 SEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLEN 1260
SEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLEN
Sbjct: 1201 SEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLEN 1260
Query: 1261 LTQGEIIYPEICMLELNLLSASKAKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTVKNLL 1320
LTQGEIIYPEICMLELNLLSASKAKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTVKNLL
Sbjct: 1261 LTQGEIIYPEICMLELNLLSASKAKLDVLAHVFESFLKIIRQKEKNVFLLMQQGTVKNLL 1320
Query: 1321 GGFLSILTQDDSDFQACQRVLVDLLVSLMSSRTCSEELTLLLRIFLEKSPCTKILLLGIL 1380
GGFLSILTQDDSDFQACQRVLVDLLVSLMSSRTCSEELTLLLRIFLEKSPCTKILLLGIL
Sbjct: 1321 GGFLSILTQDDSDFQACQRVLVDLLVSLMSSRTCSEELTLLLRIFLEKSPCTKILLLGIL 1380
Query: 1381 KIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSRSKKEADR 1440
KIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSRSKKEADR
Sbjct: 1381 KIIESDTTMSPSQYLTFPLLHAPNLSNGVSSQKYPGILNSKAMGLLRRARVSRSKKEADR 1440
Query: 1441 ESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKR 1500
ESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKR
Sbjct: 1441 ESFPHRLLSSWHIAPVHLPLLGQNCWPHLSEGFSVSLWFNVECIHEAESTTEKGKKIKKR 1500
Query: 1501 NKSLILPDSSFDGTESDRPEGAEYINPGERLIEEGCIHIISLGSKALMIQVWADPHNATL 1560
NKSLILPDSSFDGTESDRPEGAEYINPGERLIEEGCIHIISLGSKALMIQVWADPHNATL
Sbjct: 1501 NKSLILPDSSFDGTESDRPEGAEYINPGERLIEEGCIHIISLGSKALMIQVWADPHNATL 1560
Query: 1561 IFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKRRIHGKISIWVSGQ 1620
IFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKRRIHGKISIWVSGQ
Sbjct: 1561 IFRVCMDSNDDMKAVLLAQVESQENIFLPSKWQHLVLTYLQQPQGKRRIHGKISIWVSGQ 1620
Query: 1621 RKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLGNLLLFNGAKVGS 1680
RKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLGNLLLFNGAKVGS
Sbjct: 1621 RKPDVTLDFMLPRKTSLSSDSNKTFCMIGHCLSSQEEFLQLAGKWDLGNLLLFNGAKVGS 1680
Query: 1681 QEAFYLYACGPNHTSVMPCKYGKPVNDYSKYINKEILRCEQIRELFMTKKDVDIGLLIES 1740
QEAFYLYACGPNHTSVMPCKYGKPVNDYSKYINKEILRCEQIRELFMTKKDVDIGLLIES
Sbjct: 1681 QEAFYLYACGPNHTSVMPCKYGKPVNDYSKYINKEILRCEQIRELFMTKKDVDIGLLIES 1740
Query: 1741 LSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHHLKNLQPTEYKT 1800
LSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHHLKNLQPTEYKT
Sbjct: 1741 LSVVYTTYCPAQYTIYEPVIRLKGQMKTQLSQRPFSSKEVQSILLEPHHLKNLQPTEYKT 1800
Query: 1801 IQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRVHELENCNGLSM 1860
IQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRVHELENCNGLSM
Sbjct: 1801 IQGILHEIGGTGIFVFLFARVVELSSCEETQALALRVILSLIKYNQQRVHELENCNGLSM 1860
Query: 1861 IHQVLIKQKCIVGFYILKTLLEGCCGEDIIYMNENGEFKLDVDSNAIIQDVKLLEELLLD 1920
IHQVLIKQKCIVGFYILKTLLEGCCGEDIIYMNENGEFKLDVDSNAIIQDVKLLEELLLD
Sbjct: 1861 IHQVLIKQKCIVGFYILKTLLEGCCGEDIIYMNENGEFKLDVDSNAIIQDVKLLEELLLD 1920
Query: 1921 WKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQ 1980
WKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQ
Sbjct: 1921 WKIWSKAEQGVWETLLAALEVLIRADHHQQMFNIKQLLKAQVVHHFLLTCQVLQEYKEGQ 1980
Query: 1981 LTPMPREVCRSFVKIIAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHI 2040
LTPMPREVCRSFVKIIAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHI
Sbjct: 1981 LTPMPREVCRSFVKIIAEVLGSPPDLELLTIIFNFLLAVHPPTNTYVCHNPTNFYFSLHI 2040
Query: 2041 DGKIFQEKVRSIMYLRHSSSGGRSLMSPGFMVISPSGFTASPYEGENSSNIIPQQMAAHM 2100
DGKIFQEKVRSIMYLRHSSSGGRSLMSPGFMVISPSGFTASPYEGENSSNIIPQQMAAHM
Sbjct: 2041 DGKIFQEKVRSIMYLRHSSSGGRSLMSPGFMVISPSGFTASPYEGENSSNIIPQQMAAHM 2100
Query: 2101 LRSRSLPAFPTSSLLTQSQKLTGSLGCSIDRLQNIADTYVATQSKKQNSLGSSDTLKKGK 2160
LRSRSLPAFPTSSLLTQSQKLTGSLGCSIDRLQNIADTYVATQSKKQNSLGSSDTLKKGK
Sbjct: 2101 LRSRSLPAFPTSSLLTQSQKLTGSLGCSIDRLQNIADTYVATQSKKQNSLGSSDTLKKGK 2160
Query: 2161 EDAFISSCESAKTVCEMEAVLSAQVSVSDVPKGVLGFPVVKADHKQLGAEPRSEDDSPGD 2220
EDAFISSCESAKTVCEMEAVLSAQVSVSDVPKGVLGFPVVKADHKQLGAEPRSEDDSPGD
Sbjct: 2161 EDAFISSCESAKTVCEMEAVLSAQVSVSDVPKGVLGFPVVKADHKQLGAEPRSEDDSPGD 2220
Query: 2221 ESCPRRPDYLKGLASFQRSHSTIASLGLAFPSQNGSAAVGRWPSLVDRNTDDWENFAYSL 2280
ESCPRRPDYLKGLASFQRSHSTIASLGLAFPSQNGSAAVGRWPSLVDRNTDDWENFAYSL
Sbjct: 2221 ESCPRRPDYLKGLASFQRSHSTIASLGLAFPSQNGSAAVGRWPSLVDRNTDDWENFAYSL 2280
Query: 2281 GYEPNYNRTASAHSVTEDCLVPICCGLYELLSGVLLILPDVLLEDVMDKLIQADTLLVLV 2340
GYEPNYNRTASAHSVTEDCLVPICCGLYELLSGVLLILPDVLLEDVMDKLIQADTLLVLV
Sbjct: 2281 GYEPNYNRTASAHSVTEDCLVPICCGLYELLSGVLLILPDVLLEDVMDKLIQADTLLVLV 2340
Query: 2341 NHPSPAIQQGVIKLLDAYFARASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMF 2400
NHPSPAIQQGVIKLLDAYFARASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMF
Sbjct: 2341 NHPSPAIQQGVIKLLDAYFARASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMF 2400
Query: 2401 FGRHIGLDEEFDLEDVRNMGLFQKWSVIPILGLIETSLYDNILLHNALLLLLQILNSCSK 2460
FGRHIGLDEEFDLEDVRNMGLFQKWSVIPILGLIETSLYDNILLHNALLLLLQILNSCSK
Sbjct: 2401 FGRHIGLDEEFDLEDVRNMGLFQKWSVIPILGLIETSLYDNILLHNALLLLLQILNSCSK 2460
Query: 2461 VADMLLDNGLLYVLCNTVAALNGLEKNIPMSEYKLLACDIQQLFIAVTIHACSSSGSQYF 2520
VADMLLDNGLLYVLCNTVAALNGLEKNIPMSEYKLLACDIQQLFIAVTIHACSSSGSQYF
Sbjct: 2461 VADMLLDNGLLYVLCNTVAALNGLEKNIPMSEYKLLACDIQQLFIAVTIHACSSSGSQYF 2520
Query: 2521 RVIEDLIVMLGYLQNSKNKRTQNMAVALQLRVLQAAMEFIRTTANHDSENLTDSLQSPSA 2580
RVIEDLIVMLGYLQNSKNKRTQNMAVALQLRVLQAAMEFIRTTANHDSENLTDSLQSPSA
Sbjct: 2521 RVIEDLIVMLGYLQNSKNKRTQNMAVALQLRVLQAAMEFIRTTANHDSENLTDSLQSPSA 2580
Query: 2581 PHHAVVQKRKSIAGPRKFPLAQTESLLMKMRSVANDELHVMMQRRMSQENPSQATETELA 2640
PHHAVVQKRKSIAGPRKFPLAQTESLLMKMRSVANDELHVMMQRRMSQENPSQATETELA
Sbjct: 2581 PHHAVVQKRKSIAGPRKFPLAQTESLLMKMRSVANDELHVMMQRRMSQENPSQATETELA 2640
Query: 2641 QRLQRLTVLAVNRIIYQEFNSDIIDILRTPENVTQSKTSVFQTEISEENIHHEQSSVFNP 2700
QRLQRLTVLAVNRIIYQEFNSDIIDILRTPENVTQSKTSVFQTEISEENIHHEQSSVFNP
Sbjct: 2641 QRLQRLTVLAVNRIIYQEFNSDIIDILRTPENVTQSKTSVFQTEISEENIHHEQSSVFNP 2700
Query: 2701 FQKEIFTYLVEGFKVSIGSSKASGSKQQWTKILWSCKETFRMQLGRLLVHILSPAHAAQE 2760
FQKEIFTYLVEGFKVSIGSSKASGSKQQWTKILWSCKETFRMQLGRLLVHILSPAHAAQE
Sbjct: 2701 FQKEIFTYLVEGFKVSIGSSKASGSKQQWTKILWSCKETFRMQLGRLLVHILSPAHAAQE 2760
Query: 2761 RKQIFEIVHEPNHQEILRDCLSPSLQHGAKLVLYLSELIHNHQGELTEEELGTAELLMNA 2820
RKQIFEIVHEPNHQEILRDCLSPSLQHGAKLVLYLSELIHNHQGELTEEELGTAELLMNA
Sbjct: 2761 RKQIFEIVHEPNHQEILRDCLSPSLQHGAKLVLYLSELIHNHQGELTEEELGTAELLMNA 2820
Query: 2821 LKLCGHKCIPPSASTKADLIKMIKEEQKKYETEEGVNKAAWQKTVNNNQQSLFQRLDSKS 2880
LKLCGHKCIPPSASTKADLIKMIKEEQKKYETEEGVNKAAWQKTVNNNQQSLFQRLDSKS
Sbjct: 2821 LKLCGHKCIPPSASTKADLIKMIKEEQKKYETEEGVNKAAWQKTVNNNQQSLFQRLDSKS 2880
Query: 2881 KDISKIAADITQAVSLSQGNERKKVIQHIRGMYKVDLSASRHWQELIQQLTHDRAVWYDP 2940
KDISKIAADITQAVSLSQGNERKKVIQHIRGMYKVDLSASRHWQELIQQLTHDRAVWYDP
Sbjct: 2881 KDISKIAADITQAVSLSQGNERKKVIQHIRGMYKVDLSASRHWQELIQQLTHDRAVWYDP 2940
Query: 2941 IYYPTSWQLDPTEGPNRERRRLQRCYLTIPNKYLLRDRQKSEDVVKPPLSYLFEDKTHSS 3000
IYYPTSWQLDPTEGPNRERRRLQRCYLTIPNKYLLRDRQKSEDVVKPPLSYLFEDKTHSS
Sbjct: 2941 IYYPTSWQLDPTEGPNRERRRLQRCYLTIPNKYLLRDRQKSEDVVKPPLSYLFEDKTHSS 3000
Query: 3001 FSSTVKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVESSSLQGEL 3060
FSSTVKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVESSSLQGEL
Sbjct: 3001 FSSTVKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVESSSLQGEL 3060
Query: 3061 EPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFDNTKVRDDVYHNILTNNLP 3120
EPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFDNTKVRDDVYHNILTNNLP
Sbjct: 3061 EPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFDNTKVRDDVYHNILTNNLP 3120
Query: 3121 NLLEYGNITALTNLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDL 3180
NLLEYGNITALTNLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDL
Sbjct: 3121 NLLEYGNITALTNLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDL 3180
Query: 3181 NDLLIYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNS 3240
NDLLIYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNS
Sbjct: 3181 NDLLIYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNS 3240
Query: 3241 GTVLHFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYL 3300
GTVLHFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYL
Sbjct: 3241 GTVLHFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYL 3300
Query: 3301 PEFLVNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDL 3360
PEFLVNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDL
Sbjct: 3301 PEFLVNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDL 3360
Query: 3361 VFGYKQKGKASVQAINVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHV 3420
VFGYKQKGKASVQAINVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHV
Sbjct: 3361 VFGYKQKGKASVQAINVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHV 3420
Query: 3421 SRPGAKLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPV 3480
SRPGAKLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPV
Sbjct: 3421 SRPGAKLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPV 3480
Query: 3481 PVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWG 3540
PVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWG
Sbjct: 3481 PVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWG 3540
Query: 3541 YADNILRLKSKQSEPPVNFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSST 3600
YADNILRLKSKQSEPPVNFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSST
Sbjct: 3541 YADNILRLKSKQSEPPVNFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSST 3600
Query: 3601 PSEIEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSP 3660
PSEIEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSP
Sbjct: 3601 PSEIEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSP 3660
Query: 3661 VTAVSASETSGDIATVCDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGVSIN 3720
VTAVSASETSGDIATVCDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGVSIN
Sbjct: 3661 VTAVSASETSGDIATVCDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGVSIN 3720
Query: 3721 VIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAWCR 3780
VIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAWCR
Sbjct: 3721 VIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAWCR 3780
Query: 3781 KDQQRLKQPMFYSFLSSYAAG 3801
KDQQRLKQPMFYSFLSSYAAG
Sbjct: 3781 KDQQRLKQPMFYSFLSSYAAG 3801
>gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 3526
Score = 413 bits (1061), Expect = e-114
Identities = 278/807 (34%), Positives = 412/807 (51%), Gaps = 112/807 (13%)
Query: 2977 DRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGELLLG 3036
++++ +D + S E+KT ++ + ++ E I+ RC V + G LL G
Sbjct: 2501 NQEQLQDQIAEGSSIEEEEKTDNATLLRLLEEG--EKIQHMYRCARVQGLDTSEGLLLFG 2558
Query: 3037 KCGMYFVE------------------DNASDTVESSSLQG--ELEPASFSWTYEEIKEVH 3076
K Y ++ + + + QG +L+ + YE+IKEVH
Sbjct: 2559 KEHFYVIDGFTMTATREIRDIETLPPNMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVH 2618
Query: 3077 KRWWQLRDNAVEIFLTNGRTLLLAFDNTKVRDDVYHNIL-------------TNNLPNL- 3122
KR + L+ AVE+F +GR LLAF +R+ VY L + PN
Sbjct: 2619 KRRYLLQPIAVEVFSGDGRNYLLAFQKG-IRNKVYQRFLAVVPSLTDSSESVSGQRPNTS 2677
Query: 3123 LEYGN--------ITALTNLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYV 3174
+E G+ ++T W G+I+NF+YL HLN AGRS+NDLMQYPVFP+ILADY
Sbjct: 2678 VEQGSGLLSTLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYD 2737
Query: 3175 SETLDLNDLLIYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYG 3234
SE +DL + +RNL+KP+ Q E+ +Y YK E DP YHYG
Sbjct: 2738 SEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWE----------DPNGETPAYHYG 2787
Query: 3235 SHYSNSGTVLHFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELI 3294
+HYS++ V +LVRM PFT++FL Q FD+ DR FHS W +S +M DVKELI
Sbjct: 2788 THYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELI 2847
Query: 3295 PEFFYLPEFLVNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNI 3354
PEFFYLPEFL N FD G +QNG ++ V LPPWA+ DPR FI +HR+ALE DYVS ++
Sbjct: 2848 PEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHL 2907
Query: 3355 CQWIDLVFGYKQKGKASVQAINVFHPATYFG-MDVSAVEDPVQRRALETMIKTYGQTPRQ 3413
+WIDL+FGYKQ+G A+V+A+NVFH Y G +D+ + DP++ A I +GQ P+Q
Sbjct: 2908 HEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQ 2967
Query: 3414 LFHMAH-VSRPGAKLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEY 3472
LF H R ++LN + A + +L + + PS L+ +K LK E
Sbjct: 2968 LFKKPHPPKRVRSRLNGDN---AGISVLPGSTSDKIFFHHLDNLRPS-LTPVKELK--EP 3021
Query: 3473 VGSPSAPVPVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQGVRSMNSTDIQ 3532
VG +VC + I + +N L+
Sbjct: 3022 VGQ------IVC---------------TDKGILAVEQNKVLIPP---------------T 3045
Query: 3533 WSAILSWGYADNILRLKSKQSEPPVNFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAY 3592
W+ +WGYAD RL + +S+ + + ++ CA P+ + TG V+ +
Sbjct: 3046 WNKTFAWGYADLSCRLGTYESDKAMTVYECLSEWGQILCAICPNPKLVITGGTSTVVCVW 3105
Query: 3593 TNRFTSSTPSEIEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQ 3652
+ + ++ L GHT+ +T Y I++S SRD TCIIWDLN+L ++
Sbjct: 3106 EMGTSKEKAKTVTLKQA--LLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLT 3163
Query: 3653 SLAGHKSPVTAVSASETSGDIATVCDSAGGGSDLRLWTVNGDLVGHVH-----CREIICS 3707
L GH++PV+A+ +E +GDI + G+ + +W++NG+ + V+ ++IIC
Sbjct: 3164 QLRGHRAPVSALCINELTGDIVSC-----AGTYIHVWSINGNPIVSVNTFTGRSQQIIC- 3217
Query: 3708 VAFSNQPEGVSINVIAGGLENGIVRLW 3734
S E + NVI G +G+VR W
Sbjct: 3218 CCMSEMNEWDTQNVIVTGHSDGVVRFW 3244
Score = 33.1 bits (74), Expect = 5.4
Identities = 15/46 (32%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 2920 SRHWQELIQQLTHDRAVWYDPI-YYPTSWQLDPTEGPNRERRRLQR 2964
+ W ++ +L +R +W PI + W L+ TEGP R R+++ R
Sbjct: 2341 TEEWCQIECELLRERGLWGPPIGSHLDKWMLEMTEGPCRMRKKMVR 2386
>gi|191252801 WDFY family member 4 [Homo sapiens]
Length = 3184
Score = 380 bits (975), Expect = e-104
Identities = 274/911 (30%), Positives = 427/911 (46%), Gaps = 128/911 (14%)
Query: 2908 HIRGMYKVDLSASRHWQELIQQLTHDRAVWY--DPIYYPTSWQLDPTEGPNRERRRLQRC 2965
H++ ++ A+ W + +QL + +W + + W+LD EGP R R+R++R
Sbjct: 2245 HVQRRKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRL 2304
Query: 2966 -------------------YLTIPN-----KYLLRDRQKSEDVVKPPLSYL-FEDKTHSS 3000
+++ N + LR+ + D V + L F H S
Sbjct: 2305 SPLEALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHES 2364
Query: 3001 FSST------------VKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVED--- 3045
S +++ E + + V + G LL G Y E+
Sbjct: 2365 LHSEDFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTL 2424
Query: 3046 --------------NASDTVESSSLQGELEPASFSW---TYEEIKEVHKRWWQLRDNAVE 3088
N SD + + +S +Y +++E+ + + L+D A+E
Sbjct: 2425 SPTGDVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALE 2484
Query: 3089 IFLTNGRTLLLAFDNT----------KVRDDVYHNILTNNLPNLLEY-GNITALTNLWYT 3137
IF NG + L F N + + + + +L Y G+ + W
Sbjct: 2485 IFFHNGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQK 2544
Query: 3138 GQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLSKPIAVQY 3197
I+NFEYL +LN AGR+ ND MQYPVFP++LADY SETL+L + I+R+LSKP+ Q
Sbjct: 2545 RDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQT 2604
Query: 3198 KEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMF 3257
KE++ +++ +K +E+ E D HY +HYS++ V +LVRMPPFT+ F
Sbjct: 2605 KERKLKFIQRFKEVEKT------EGDMTVQC---HYYTHYSSAIIVASYLVRMPPFTQAF 2655
Query: 3258 LAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQN 3317
A Q SFD+ DR FHS +TW +S E+M+DV+EL PEFFYLPEFL N G +FG Q+
Sbjct: 2656 CALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQD 2715
Query: 3318 GERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINV 3377
G + V LPPWA DPR FI +HR+ALESD+VS N+ WIDL+FGYKQ+G A+V A+N+
Sbjct: 2716 GTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNI 2775
Query: 3378 FHPATYFG-MDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGAKLNIEGELPAA 3436
FHP Y MD+S++ DP+ + + + +GQ P+QLF H +R A + G
Sbjct: 2776 FHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPG----- 2830
Query: 3437 VGLLVQFAFRETREQVKEITYPSPLSW-IKGLKWGEYVGSPSAPVPVVCFSQPHGERFGS 3495
++ V +P P + ++ L+ S + FS G+
Sbjct: 2831 ---------KDVSTPVSLPGHPQPFFYSLQSLR-----PSQVTVKDMYLFSLGSESPKGA 2876
Query: 3496 LQALPT--RAICGLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYADNILRLKSKQS 3553
+ + + + I + RN LL W+ SWG+ D L S S
Sbjct: 2877 IGHIVSTEKTILAVERNKVLLPPL---------------WNRTFSWGFDDFSCCLGSYGS 2921
Query: 3554 EPPVNFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLY 3613
+ + ++ + CA P + T V+ + T P + + LY
Sbjct: 2922 DKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQA--LY 2979
Query: 3614 GHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDI 3673
GHT+ +T L +S+L+S S+D TCI+WDL+ L +V L H+ ++A++ S+ SG I
Sbjct: 2980 GHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTI 3039
Query: 3674 ATVCDSAGGGSDLRLWTVNGDLVGHVHC----REIICSVAFSNQPEGVSINVIAGGLENG 3729
+ G+ L LW VNG + + I P + +I G ++G
Sbjct: 3040 VSC-----AGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDG 3094
Query: 3730 IVRLWSTWDLK 3740
+VR+W T D+K
Sbjct: 3095 MVRVWKTEDVK 3105
>gi|224451124 neurobeachin-like 1 isoform 3 [Homo sapiens]
Length = 2694
Score = 324 bits (831), Expect = 9e-88
Identities = 249/791 (31%), Positives = 384/791 (48%), Gaps = 82/791 (10%)
Query: 2917 LSASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCY--LTIPNKYL 2974
L+ R W+ + LT +R W P W+L E +R R +L Y T
Sbjct: 1769 LATLRRWKAIQLYLTCERGPWAKRKQNPIHWKLANVENYSRMRLKLVPNYNFKTHEEASA 1828
Query: 2975 LRDRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGE-- 3032
LRD + + L E S V+DK + R ++V E +
Sbjct: 1829 LRDNLGIQHSQPSSDTLLLEVVKQVKVSDMVEDKLDLPEEDITAR-VNVDEKEEQDQKEK 1887
Query: 3033 -LLLGKCGMYFVEDNASDTVESSS-----LQGELEPAS-----FSWTYEEIKEVHKRWWQ 3081
+L+ C + + D +E ++ G +E F W + +I+E+H R +
Sbjct: 1888 LVLMEDCELITIIDVIPGRLEITTQHIYFYDGSIEKEDGVGFDFKWPHSQIREIHLRRYN 1947
Query: 3082 LRDNAVEIFLTNGRTLLLAFDNTKVRDDVYHNILTNNLPNLLEYGN--------ITALTN 3133
LR +A+EIF + L F +VR+ +Y +L+ + PN YG+ + LT
Sbjct: 1948 LRRSALEIFHVDQSNYFLNFKK-EVRNKIYSRLLSLHSPNSY-YGSRSPQELFKASGLTQ 2005
Query: 3134 LWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLSKPI 3193
W +I+NF+YL +N AGR++NDL QYPVFP+IL DY SE LDLN+ ++R+LSKPI
Sbjct: 2006 KWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLNNPAVFRDLSKPI 2065
Query: 3194 AVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPF 3253
V ++ + Y+ E DPM + +HYG+HYSNS V+H+L+R+ PF
Sbjct: 2066 GVVNEKNAKAMREKYENFE----------DPMGTIDKFHYGTHYSNSAGVMHYLIRVEPF 2115
Query: 3254 TKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFG 3313
T + + Q FD DR FHS TW+ + ++ DVKELIPEFFY PEFL N+ F+ G
Sbjct: 2116 TTLHIQLQSGRFDCADRQFHSIPATWQ-ALMDNPYDVKELIPEFFYFPEFLENQNQFNLG 2174
Query: 3314 VRQ-NGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASV 3372
Q + E VN V LP WA++ FI HR+ALES+YVS ++ +WIDL+FGYKQ+G A+V
Sbjct: 2175 RLQISKELVNDVILPKWAKS-AEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRGPAAV 2233
Query: 3373 QAINVFHPATYFG-MDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGAKLNIEG 3431
+A+NVF+ +Y G +D+ A+ D +R+ALE MI +GQTP QL H R A+ +
Sbjct: 2234 EALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLLKEPHPPRLSAEEAV-- 2291
Query: 3432 ELPAAVGLLVQFAFRETREQ----VKEITYPSPL--SWIKGLKWGEYVGSPSAPVPVVCF 3485
+ P + F+ E ++ I+ PL + I ++ ++ S +P ++
Sbjct: 2292 QKPTKIDTSTLNLFQHLPELKSFFIEGISDGIPLLKATIPKNQYRSFM-SQGSPELLITI 2350
Query: 3486 SQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQGV------RSMNST---------- 3529
S + + T RN T+ K+Q V RS+N +
Sbjct: 2351 SMNY--------VIGTHGWLPYDRNISNYFTFIKDQTVTNPKTQRSINGSFAPGLEITSK 2402
Query: 3530 ----DIQWSAILSWGYADNILRLKSKQSEPPVNFIQSSQQYQVTSCAWVPDSC--QLFTG 3583
+ S GY DN +++ S ++ I + + +C D C L +G
Sbjct: 2403 LFVVSHDAKLLFSAGYWDNSIQVMSLTKGKIISHI--IRHMDIVTCL-ATDYCGIHLISG 2459
Query: 3584 SKCGVITAYTNRFTSSTPSEIEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIW 3643
S+ + P + + LYGHT E+ S+ + + +S SRDGT II
Sbjct: 2460 SRDTTCMIWQITQQGGVPVGLASKPFQILYGHTNEVLSVGISTELDMAVSGSRDGTVIIH 2519
Query: 3644 DLNRLCYVQSL 3654
+ + Y+++L
Sbjct: 2520 TIQKGQYMRTL 2530
>gi|149944613 neurobeachin-like 1 isoform 1 [Homo sapiens]
Length = 1404
Score = 324 bits (831), Expect = 9e-88
Identities = 249/791 (31%), Positives = 384/791 (48%), Gaps = 82/791 (10%)
Query: 2917 LSASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCY--LTIPNKYL 2974
L+ R W+ + LT +R W P W+L E +R R +L Y T
Sbjct: 479 LATLRRWKAIQLYLTCERGPWAKRKQNPIHWKLANVENYSRMRLKLVPNYNFKTHEEASA 538
Query: 2975 LRDRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGE-- 3032
LRD + + L E S V+DK + R ++V E +
Sbjct: 539 LRDNLGIQHSQPSSDTLLLEVVKQVKVSDMVEDKLDLPEEDITAR-VNVDEKEEQDQKEK 597
Query: 3033 -LLLGKCGMYFVEDNASDTVESSS-----LQGELEPAS-----FSWTYEEIKEVHKRWWQ 3081
+L+ C + + D +E ++ G +E F W + +I+E+H R +
Sbjct: 598 LVLMEDCELITIIDVIPGRLEITTQHIYFYDGSIEKEDGVGFDFKWPHSQIREIHLRRYN 657
Query: 3082 LRDNAVEIFLTNGRTLLLAFDNTKVRDDVYHNILTNNLPNLLEYGN--------ITALTN 3133
LR +A+EIF + L F +VR+ +Y +L+ + PN YG+ + LT
Sbjct: 658 LRRSALEIFHVDQSNYFLNFKK-EVRNKIYSRLLSLHSPNSY-YGSRSPQELFKASGLTQ 715
Query: 3134 LWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLSKPI 3193
W +I+NF+YL +N AGR++NDL QYPVFP+IL DY SE LDLN+ ++R+LSKPI
Sbjct: 716 KWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLNNPAVFRDLSKPI 775
Query: 3194 AVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPF 3253
V ++ + Y+ E DPM + +HYG+HYSNS V+H+L+R+ PF
Sbjct: 776 GVVNEKNAKAMREKYENFE----------DPMGTIDKFHYGTHYSNSAGVMHYLIRVEPF 825
Query: 3254 TKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFG 3313
T + + Q FD DR FHS TW+ + ++ DVKELIPEFFY PEFL N+ F+ G
Sbjct: 826 TTLHIQLQSGRFDCADRQFHSIPATWQ-ALMDNPYDVKELIPEFFYFPEFLENQNQFNLG 884
Query: 3314 VRQ-NGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASV 3372
Q + E VN V LP WA++ FI HR+ALES+YVS ++ +WIDL+FGYKQ+G A+V
Sbjct: 885 RLQISKELVNDVILPKWAKS-AEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRGPAAV 943
Query: 3373 QAINVFHPATYFG-MDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGAKLNIEG 3431
+A+NVF+ +Y G +D+ A+ D +R+ALE MI +GQTP QL H R A+ +
Sbjct: 944 EALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQLLKEPHPPRLSAEEAV-- 1001
Query: 3432 ELPAAVGLLVQFAFRETREQ----VKEITYPSPL--SWIKGLKWGEYVGSPSAPVPVVCF 3485
+ P + F+ E ++ I+ PL + I ++ ++ S +P ++
Sbjct: 1002 QKPTKIDTSTLNLFQHLPELKSFFIEGISDGIPLLKATIPKNQYRSFM-SQGSPELLITI 1060
Query: 3486 SQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQGV------RSMNST---------- 3529
S + + T RN T+ K+Q V RS+N +
Sbjct: 1061 SMNY--------VIGTHGWLPYDRNISNYFTFIKDQTVTNPKTQRSINGSFAPGLEITSK 1112
Query: 3530 ----DIQWSAILSWGYADNILRLKSKQSEPPVNFIQSSQQYQVTSCAWVPDSC--QLFTG 3583
+ S GY DN +++ S ++ I + + +C D C L +G
Sbjct: 1113 LFVVSHDAKLLFSAGYWDNSIQVMSLTKGKIISHI--IRHMDIVTCL-ATDYCGIHLISG 1169
Query: 3584 SKCGVITAYTNRFTSSTPSEIEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIW 3643
S+ + P + + LYGHT E+ S+ + + +S SRDGT II
Sbjct: 1170 SRDTTCMIWQITQQGGVPVGLASKPFQILYGHTNEVLSVGISTELDMAVSGSRDGTVIIH 1229
Query: 3644 DLNRLCYVQSL 3654
+ + Y+++L
Sbjct: 1230 TIQKGQYMRTL 1240
>gi|62422577 neurobeachin [Homo sapiens]
Length = 2946
Score = 314 bits (805), Expect = 9e-85
Identities = 274/1002 (27%), Positives = 461/1002 (46%), Gaps = 139/1002 (13%)
Query: 2865 VNNNQQSLFQRLDSKSKDISKIAADITQAVSLSQGN-ERKKVIQHI--RGMYKVDLSASR 2921
V N + + R +++D+ K A +Q + E +K+ H+ ++ ++A++
Sbjct: 1981 VANEAEFILNR--QRAEDVHKHAEFESQCAQYAADRREEEKMCDHLISAAKHRDHVTANQ 2038
Query: 2922 HWQELIQQLTHDRAVWYDPIYYPTS--WQLDPTEGPNRERRRLQR-CYLTIPNKYLLR-- 2976
Q+++ LT+ W + W+LD E R RRR R + + + LL+
Sbjct: 2039 LKQKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKAA 2098
Query: 2977 -DRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRR---------------C 3020
+ EDVVK ++ + + + + + + +++ + +
Sbjct: 2099 IEYGTEEDVVKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPA 2158
Query: 3021 ISVAPSRETAGELLLGKCGMYFV--EDNASDTVESSSLQGELEPASFSWTYEEIKEVHKR 3078
+AP G L + +YF ED+++ + + E W + EI+ V R
Sbjct: 2159 QLIAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWMFSEIRAVFSR 2218
Query: 3079 WWQLRDNAVEIFLTNGRTLLLAF-DNTKVRDDVYH----NILTN-NLPNLLEYGNITA-- 3130
+ L++ A+E+F+ N +++ F D V+ VY + T+ LP T
Sbjct: 2219 RYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQ 2278
Query: 3131 ------LTNLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLL 3184
+T W +I+NFEYL LN AGR++NDL QYPVFP++L +Y SE LDL
Sbjct: 2279 LYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPG 2338
Query: 3185 IYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVL 3244
+R+LSKPI ++ Y + Y+ EDD P PYHY +HYS + + L
Sbjct: 2339 NFRDLSKPIGALNPKRAVFYAERYE---------TWEDDQSP---PYHYNTHYSTATSTL 2386
Query: 3245 HFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFL 3304
+LVR+ PFT FL D FD PDRTF S +WR S ++ +DVKELIPEF+YLPE
Sbjct: 2387 SWLVRIEPFTTFFLNANDGKFDHPDRTFSSVARSWRTSQRDT-SDVKELIPEFYYLPEMF 2445
Query: 3305 VNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGY 3364
VN G++ GVR++ VN V+LPPWA+ P F+ I+R ALES++VS + QWIDL+FGY
Sbjct: 2446 VNSNGYNLGVREDEVVVNDVDLPPWAKK-PEDFVRINRMALESEFVSCQLHQWIDLIFGY 2504
Query: 3365 KQKGKASVQAINVFHPATYFG-MDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSR- 3422
KQ+G +V+A+NVFH TY G +++ ++ DPV R A+E I+ +GQTP QL H R
Sbjct: 2505 KQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRS 2564
Query: 3423 --------PGAKLNIEGELPAAVGLLVQFAFRETREQVKEITYP------------SPLS 3462
P + L + ++ V ++++F V T P S L
Sbjct: 2565 SAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLF 2624
Query: 3463 WIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYSKEQG 3522
+ +W VG AP G LP ++ N G
Sbjct: 2625 AVN--RWHNTVGLRGAP----------GYSLDQAHHLPIEMDPLIANN----------SG 2662
Query: 3523 VRSMNSTD-----IQWSA-----------ILSWGYADNILRLKSKQSEPPVNFIQSSQQY 3566
V TD IQ +A IL G+ D R+ S ++ + +
Sbjct: 2663 VNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFG--HW 2720
Query: 3567 QVTSC-----AWVPDSCQLFTGSKCGVITAY----TNRFTSSTPSEIEMET-QIHLYGHT 3616
V +C +++ C + +GS+ + + + P+ + + L GH
Sbjct: 2721 DVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHD 2780
Query: 3617 EEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATV 3676
E+ + VC ++IS +++G C++ + +++L G ++ + S +S +
Sbjct: 2781 HEVVCVSVCAELGLVISGAKEGPCLVHTITG-DLLRALEGPENCLFPRLISVSSEGHCII 2839
Query: 3677 CDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGVSINVIAGGLENGIVRLWST 3736
G S+ +++NG L+ + + ++ S+ + N++ GG +NG+V +W
Sbjct: 2840 YYERGRFSN---FSINGKLLAQMEINDSTRAILLSSDGQ----NLVTGG-DNGVVEVWQA 2891
Query: 3737 WDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
D K + +P + I ++ S D L T + G+++A+
Sbjct: 2892 CDFKQL--YIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAF 2931
>gi|154240744 neurobeachin-like 1 isoform 2 [Homo sapiens]
Length = 1335
Score = 305 bits (782), Expect = 4e-82
Identities = 195/523 (37%), Positives = 284/523 (54%), Gaps = 40/523 (7%)
Query: 2917 LSASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCY--LTIPNKYL 2974
L+ R W+ + LT +R W P W+L E +R R +L Y T
Sbjct: 479 LATLRRWKAIQLYLTCERGPWAKRKQNPIHWKLANVENYSRMRLKLVPNYNFKTHEEASA 538
Query: 2975 LRDRQKSEDVVKPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGE-- 3032
LRD + + L E S V+DK + R ++V E +
Sbjct: 539 LRDNLGIQHSQPSSDTLLLEVVKQVKVSDMVEDKLDLPEEDITAR-VNVDEKEEQDQKEK 597
Query: 3033 -LLLGKCGMYFVEDNASDTVESSS-----LQGELEPAS-----FSWTYEEIKEVHKRWWQ 3081
+L+ C + + D +E ++ G +E F W + +I+E+H R +
Sbjct: 598 LVLMEDCELITIIDVIPGRLEITTQHIYFYDGSIEKEDGVGFDFKWPHSQIREIHLRRYN 657
Query: 3082 LRDNAVEIFLTNGRTLLLAFDNTKVRDDVYHNILTNNLPNLLEYGN--------ITALTN 3133
LR +A+EIF + L F +VR+ +Y +L+ + PN YG+ + LT
Sbjct: 658 LRRSALEIFHVDQSNYFLNFKK-EVRNKIYSRLLSLHSPNSY-YGSRSPQELFKASGLTQ 715
Query: 3134 LWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLSKPI 3193
W +I+NF+YL +N AGR++NDL QYPVFP+IL DY SE LDLN+ ++R+LSKPI
Sbjct: 716 KWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLNNPAVFRDLSKPI 775
Query: 3194 AVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPF 3253
V ++ + Y+ E DPM + +HYG+HYSNS V+H+L+R+ PF
Sbjct: 776 GVVNEKNAKAMREKYENFE----------DPMGTIDKFHYGTHYSNSAGVMHYLIRVEPF 825
Query: 3254 TKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFG 3313
T + + Q FD DR FHS TW+ + ++ DVKELIPEFFY PEFL N+ F+ G
Sbjct: 826 TTLHIQLQSGRFDCADRQFHSIPATWQ-ALMDNPYDVKELIPEFFYFPEFLENQNQFNLG 884
Query: 3314 VRQ-NGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASV 3372
Q + E VN V LP WA++ FI HR+ALES+YVS ++ +WIDL+FGYKQ+G A+V
Sbjct: 885 RLQISKELVNDVILPKWAKS-AEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRGPAAV 943
Query: 3373 QAINVFHPATYFG-MDVSAVEDPVQRRALETMIKTYGQTPRQL 3414
+A+NVF+ +Y G +D+ A+ D +R+ALE MI +GQTP QL
Sbjct: 944 EALNVFYYCSYEGAVDLDALTDEKERKALEGMINNFGQTPCQL 986
Score = 39.7 bits (91), Expect = 0.058
Identities = 31/121 (25%), Positives = 55/121 (45%), Gaps = 5/121 (4%)
Query: 3536 ILSWGYADNILRLKSKQSEPPVNFIQSSQQYQVTSCAWVPDSC--QLFTGSKCGVITAYT 3593
+ S GY DN +++ S ++ I + + +C D C L +GS+ +
Sbjct: 1054 LFSAGYWDNSIQVMSLTKGKIISHI--IRHMDIVTCL-ATDYCGIHLISGSRDTTCMIWQ 1110
Query: 3594 NRFTSSTPSEIEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQS 3653
P + + LYGHT E+ S+ + + +S SRDGT II + + Y+++
Sbjct: 1111 ITQQGGVPVGLASKPFQILYGHTNEVLSVGISTELDMAVSGSRDGTVIIHTIQKGQYMRT 1170
Query: 3654 L 3654
L
Sbjct: 1171 L 1171
>gi|149944548 neurobeachin-like 2 [Homo sapiens]
Length = 2754
Score = 293 bits (750), Expect = 2e-78
Identities = 285/981 (29%), Positives = 433/981 (44%), Gaps = 164/981 (16%)
Query: 2848 KKYETEEGVNKAAWQKTVNNNQQSLFQRLDSKSKDISKIAADITQAVSLSQGNERKKVIQ 2907
K ++ G A + +++ Q+ ++R S+ + ++ + Q + +G V++
Sbjct: 1732 KSHDLMSGFWNACYDMLMSSGQRRQWERAQSR-RAFQELVLEPAQRRARLEGLRYTAVLK 1790
Query: 2908 HIRGMYKVDLSASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCYL 2967
+ + L HW L +QL W W+L E +R R +L
Sbjct: 1791 QQATQHSMALL---HWGALWRQLASPCGAWALRDTPIPRWKLSSAETYSRMRLKL----- 1842
Query: 2968 TIPNKYL--------LRDRQ-----------------KSEDVVKPPLSYLFEDKTHSSFS 3002
+PN + LRD E V P L ED+
Sbjct: 1843 -VPNHHFDPHLEASALRDNLGEVPLTPTEEASLPLAVTKEAKVSTPPELLQEDQLGEDEL 1901
Query: 3003 STVKDKAAS-------ESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVESSS 3055
+ ++ + E + ++ C V G L + +YF D +++ VE+
Sbjct: 1902 AELETPMEAAELDEQREKLVLSAECQLVTVVAVVPGLLEVTTQNVYFY-DGSTERVETEE 1960
Query: 3056 LQGELEPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFD------------- 3102
G F +++EVH R + LR +A+E+F + L F
Sbjct: 1961 GIGY----DFRRPLAQLREVHLRRFNLRRSALELFFIDQANYFLNFPCKVGTTPVSSPSQ 2016
Query: 3103 -----------NTKVRDDVYHNILTNNLPNL--------LEYGNITALTNLWYTGQITNF 3143
+T+VR+ VY +L P+ E + LT W +I+NF
Sbjct: 2017 TPRPQPGPIPPHTQVRNQVYSWLLRLRPPSQGYLSSRSPQEMLRASGLTQKWVQREISNF 2076
Query: 3144 EYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLSKPIAVQYKEKEDR 3203
EYL LN AGR++NDL QYPVFP++L DYVS TLDL++ ++R+LSKPI V +
Sbjct: 2077 EYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQL 2136
Query: 3204 YVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMFLAYQDQ 3263
+ Y+ E DP + +HYG+HYSN+ V+H+L+R+ PFT + + Q
Sbjct: 2137 VREKYESFE----------DPAGTIDKFHYGTHYSNAAGVMHYLIRVEPFTSLHVQLQSG 2186
Query: 3264 SFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQ-NGERVN 3322
FD DR FHS W+ + ES DVKELIPEFFY P+FL N+ GFD G Q E+V
Sbjct: 2187 RFDCSDRQFHSVAAAWQ-ARLESPADVKELIPEFFYFPDFLENQNGFDLGCLQLTNEKVG 2245
Query: 3323 HVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINVFHPAT 3382
V LPPWA + P FI HRQALES+YVS ++ +WIDL+FGYKQ+G A+ +A+NVF+ T
Sbjct: 2246 DVVLPPWA-SSPEDFIQQHRQALESEYVSAHLHEWIDLIFGYKQRGPAAEEALNVFYYCT 2304
Query: 3383 YFG-MDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGAKLNIEGELPAAVGLLV 3441
Y G +D+ V D +R+ALE +I +GQTP QL H +R A+
Sbjct: 2305 YEGAVDLDHVTDERERKALEGIISNFGQTPCQLLKEPHPTRLSAE--------------- 2349
Query: 3442 QFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPT 3501
+ A R R + PS + LK + S VP+V PH + P
Sbjct: 2350 EAAHRLAR---LDTNSPSIFQHLDELK-AFFAEVVSDGVPLVLALVPHRQ--------PH 2397
Query: 3502 RAICGLSRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYADNILRLKSKQ--SEPPVNF 3559
I S + + ++ S G S D S S+ + K+++ S P V
Sbjct: 2398 SFITQGSPDLLVTVSASGLLGTHSWLPYDRNISNYFSFSKDPTMGSHKTQRLLSGPWVPG 2457
Query: 3560 IQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYGHTEEI 3619
S Q + A PD LF+G + R T+ ++ + HL + +
Sbjct: 2458 SGVSGQ----ALAVAPDGKLLFSGGHWD----GSLRVTALPRGKLLSQLSCHL----DVV 2505
Query: 3620 TSLFVCKPYSILISVSRDGTCIIWDLNRLCY------------VQSLAGHKSPVTAVSAS 3667
T L + LIS SRD TC++W RL + VQ L GH + V+ V+
Sbjct: 2506 TCLALDTCGIYLISGSRDTTCMVW---RLLHQGGLSVGLAPKPVQVLYGHGAAVSCVA-- 2560
Query: 3668 ETSGDIATVCDSAGGGSDLRLWTVNGDLVGH-VHCREIICSVAFSNQPEGVSINVIAGGL 3726
I+T D A GS+ +G ++ H V + + ++ I +A G
Sbjct: 2561 -----ISTELDMAVSGSE------DGTVIIHTVRRGQFVAALRPLGATFPGPIFHLALGS 2609
Query: 3727 ENGIVRLWSTWDLKPVREITF 3747
E IV S W+ +P ++T+
Sbjct: 2610 EGQIVVQSSAWE-RPGAQVTY 2629
>gi|148233596 LPS-responsive vesicle trafficking, beach and anchor
containing [Homo sapiens]
Length = 2863
Score = 267 bits (683), Expect = 1e-70
Identities = 192/578 (33%), Positives = 288/578 (49%), Gaps = 68/578 (11%)
Query: 2901 ERKKVIQHI--RGMYKVDLSASRHWQELIQQLTHDRAVWYDP-IYYPTS-WQLDPTEGPN 2956
E +K+ H+ Y+ ++A++ Q++I LT W + + P W+LD E
Sbjct: 1930 EDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFWRLDYWEDDL 1989
Query: 2957 RERRRLQRCYL--TIPNKYL-----------LRDRQKS--EDVVKPPLSYLF-------- 2993
R RRR R L T P L LR+ K+ ED++ +
Sbjct: 1990 RRRRRFVRNPLGSTHPEATLKTAVEHVCIFKLRENSKATDEDILAKGKQSIRSQALGNQN 2049
Query: 2994 ---------EDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVE 3044
+D T SS + A + ++ VAPS G L + +YF
Sbjct: 2050 SENEILLEGDDDTLSSVDEKDLENLAGP-VSLSTPAQLVAPSVVVKGTLSVTSSELYFEV 2108
Query: 3045 DNASDTVES--SSLQGELEPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFD 3102
D + + E W + EI+ + R + L++ A+EIF+ N ++ F
Sbjct: 2109 DEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFP 2168
Query: 3103 NTKVRDDVYHNI------LTNNLPNLLEYG--------NITALTNLWYTGQITNFEYLTH 3148
+ V + + + LP + +T W +I+NFEYL
Sbjct: 2169 DPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMF 2228
Query: 3149 LNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLSKPIAVQYKEKEDRYVDTY 3208
LN AGRS+NDL QYPVFP+++ +Y SE LDL +R+LSKPI ++ + + Y
Sbjct: 2229 LNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERY 2288
Query: 3209 KYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMFLAYQDQSFDIP 3268
+ + EDD +P +HYG+HYS + VL +L+R+ PFT FL Q FD
Sbjct: 2289 E---------SWEDDQVP---KFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHA 2336
Query: 3269 DRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQNGERVNHVNLPP 3328
DRTF S + WR +S +D+KELIPEF+YLPE VN ++ GV +G V+ V LPP
Sbjct: 2337 DRTFSSISRAWR-NSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPP 2395
Query: 3329 WARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINVFHPATYFG-MD 3387
WA+ F+ I+R ALES++VS + QWIDL+FGYKQ+G +V+A+NVF+ TY G ++
Sbjct: 2396 WAKTSEE-FVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVN 2454
Query: 3388 VSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGA 3425
++++ DPV R A+E I+++GQTP QL H R A
Sbjct: 2455 LNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSA 2492
Score = 37.0 bits (84), Expect = 0.37
Identities = 50/250 (20%), Positives = 99/250 (39%), Gaps = 22/250 (8%)
Query: 3536 ILSWGYADNILRLKSKQSEPPVNFIQSSQQYQVTSC-----AWVPDSCQLFTGSKCGVIT 3590
IL G+ D R+ S + + + + V +C +++ +C + +GS+ +
Sbjct: 2610 ILVCGFWDKSFRVYSTDTGRLIQVVFG--HWDVVTCLARSESYIGGNCYILSGSRDATLL 2667
Query: 3591 A-YTNRFTSSTPSEIEMET---QIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLN 3646
Y N S ET + L GH E+T VC +++S S++G C+I +N
Sbjct: 2668 LWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMN 2727
Query: 3647 RLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGGGSDLRLWTVNGDLVGHVHCREIIC 3706
L + P + C ++VNG L + + I
Sbjct: 2728 G----DLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIR 2783
Query: 3707 SVAFSNQPEGVSINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHL 3766
++ S + ++ GG + G+V + DLK + +P + I ++ S D +
Sbjct: 2784 AIQLSRDGQ----YLLTGG-DRGVVVVRQVSDLKQL--FAYPGCDAGIRAMALSYDQRCI 2836
Query: 3767 YTANSDGTVI 3776
+ + G+++
Sbjct: 2837 ISGMASGSIV 2846
Score = 34.7 bits (78), Expect = 1.9
Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 23/180 (12%)
Query: 1081 TEAAPEEAKLFTSQESETSLQSIRLLEALLAICLHGARTSQQKMELELPNQNLSVESILF 1140
T+ +P T+ +S++ LE+ I L TS ++M+ E NQ L E L
Sbjct: 976 TKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLE 1035
Query: 1141 EMRDHLSQSKVIETQLAKPLFDALLRVALGNYSADFEHNDAMTEKSHQSAEELSSQPGDF 1200
E + +++ + +++ + +A VA+ + S D+MT +E +S
Sbjct: 1036 ETLTNETRN-ADDLEVSSDIIEA---VAISSNSFITTGKDSMTV-----SEVTASISSPS 1086
Query: 1201 SEEAEDSQCCSFKLLVEEEGYEADSESNPEDGETQDDGVDLKSETEGFSASSSPNDLLEN 1260
E+A + K +VEEE ED DD V+LK E ++ P +L +N
Sbjct: 1087 EEDASEMPEFLDKSIVEEE----------ED----DDYVELKVEGSPTEEANLPTELQDN 1132
>gi|31543297 neutral sphingomyelinase (N-SMase) activation associated
factor isoform 1 [Homo sapiens]
Length = 917
Score = 252 bits (644), Expect = 4e-66
Identities = 225/783 (28%), Positives = 347/783 (44%), Gaps = 117/783 (14%)
Query: 3011 SESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVESSSLQGELEPASFSWTYE 3070
SE + + + V P G + + +YF L G +P T +
Sbjct: 191 SEKLHMECKAEMVTPLVTNPGHVCITDTNLYF-----------QPLNGYPKPV-VQITLQ 238
Query: 3071 EIKEVHKRWWQLRDNAVEIFLTNG---RTLLLAFDNTKVRDDVYHNILTNNLPNLLEYGN 3127
+++ ++KR L +E+F T + L F + RDD+Y I T ++ E+
Sbjct: 239 DVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTA 298
Query: 3128 ITALTNLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYR 3187
+ + W G ++N++YL HLN A RS NDL QYPVFP+I+ DY S LDL++ +R
Sbjct: 299 ESYMLQ-WQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPGTFR 357
Query: 3188 NLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFL 3247
+LSKP+ KE+ +R + Y+ + P + YGSHYS+ G VL +L
Sbjct: 358 DLSKPVGALNKERLERLLTRYQEM---------------PEPKFMYGSHYSSPGYVLFYL 402
Query: 3248 VRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLP-EFLVN 3306
VR+ P + L Q+ FD DR F+S TW+ + + TD KELIPEF+ FLVN
Sbjct: 403 VRIAP--EYMLCLQNGRFDNADRMFNSIAETWK-NCLDGATDFKELIPEFYGDDVSFLVN 459
Query: 3307 REGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQ 3366
D G RQ G+ V+ V LPPWA + P F+ + ALES+YVS+++ +WIDL+FGYKQ
Sbjct: 460 SLKLDLGKRQGGQMVDDVELPPWA-SSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQ 518
Query: 3367 KGKASVQAINVFHPATY-FGMDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGA 3425
KG +V A NVFHP TY G+D+++++DP ++ A+ T I +GQTP+QLF H R
Sbjct: 519 KGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRITP 578
Query: 3426 KLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCF 3485
K L A E +++T S K L W +
Sbjct: 579 KFK---SLSQTSSYNASMADSPGEESFEDLTEES-----KTLAWNN-----------ITK 619
Query: 3486 SQPHGERFGSLQALPTRAICGL--SRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYAD 3543
Q H + A+ G+ SRN + T S+ D
Sbjct: 620 LQLHEH-----YKIHKEAVTGITVSRNGSSVFTTSQ-----------------------D 651
Query: 3544 NILRLKSKQSEPPVNFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSE 3603
+ L++ SK+S+ I S ++SC +P + T S + Y+ F
Sbjct: 652 STLKMFSKESKMLQRSISFSNM-ALSSCLLLPGDATVITSSWDNNVYFYSIAFG------ 704
Query: 3604 IEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTA 3663
Q L GH + ++ +C + L S S D T +W + H + A
Sbjct: 705 ---RRQDTLMGHDDAVSK--ICWHDNRLYSASWDSTVKVWS-GVPAEMPGTKRHHFDLLA 758
Query: 3664 VSASETSGD------IATVCDSAGGGSDLRLWTV-NGDLVGHVHCRE-IICSVAFSNQPE 3715
+ S D +T+ S + +W + L+ + C I+C AFS
Sbjct: 759 ELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSR 818
Query: 3716 GVSINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTV 3775
V L G + D++ I+ S++P F DG+ + + + G +
Sbjct: 819 HV--------LSTGTDGCLNVIDVQTGMLISSMTSDEP--QRCFVWDGNSVLSGSQSGEL 868
Query: 3776 IAW 3778
+ W
Sbjct: 869 LVW 871
>gi|221625547 neutral sphingomyelinase (N-SMase) activation associated
factor isoform 2 [Homo sapiens]
Length = 948
Score = 252 bits (644), Expect = 4e-66
Identities = 225/783 (28%), Positives = 347/783 (44%), Gaps = 117/783 (14%)
Query: 3011 SESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDTVESSSLQGELEPASFSWTYE 3070
SE + + + V P G + + +YF L G +P T +
Sbjct: 222 SEKLHMECKAEMVTPLVTNPGHVCITDTNLYF-----------QPLNGYPKPV-VQITLQ 269
Query: 3071 EIKEVHKRWWQLRDNAVEIFLTNG---RTLLLAFDNTKVRDDVYHNILTNNLPNLLEYGN 3127
+++ ++KR L +E+F T + L F + RDD+Y I T ++ E+
Sbjct: 270 DVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTA 329
Query: 3128 ITALTNLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYR 3187
+ + W G ++N++YL HLN A RS NDL QYPVFP+I+ DY S LDL++ +R
Sbjct: 330 ESYMLQ-WQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPGTFR 388
Query: 3188 NLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFL 3247
+LSKP+ KE+ +R + Y+ + P + YGSHYS+ G VL +L
Sbjct: 389 DLSKPVGALNKERLERLLTRYQEM---------------PEPKFMYGSHYSSPGYVLFYL 433
Query: 3248 VRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLP-EFLVN 3306
VR+ P + L Q+ FD DR F+S TW+ + + TD KELIPEF+ FLVN
Sbjct: 434 VRIAP--EYMLCLQNGRFDNADRMFNSIAETWK-NCLDGATDFKELIPEFYGDDVSFLVN 490
Query: 3307 REGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQ 3366
D G RQ G+ V+ V LPPWA + P F+ + ALES+YVS+++ +WIDL+FGYKQ
Sbjct: 491 SLKLDLGKRQGGQMVDDVELPPWA-SSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQ 549
Query: 3367 KGKASVQAINVFHPATY-FGMDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGA 3425
KG +V A NVFHP TY G+D+++++DP ++ A+ T I +GQTP+QLF H R
Sbjct: 550 KGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRITP 609
Query: 3426 KLNIEGELPAAVGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCF 3485
K L A E +++T S K L W +
Sbjct: 610 KFK---SLSQTSSYNASMADSPGEESFEDLTEES-----KTLAWNN-----------ITK 650
Query: 3486 SQPHGERFGSLQALPTRAICGL--SRNFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYAD 3543
Q H + A+ G+ SRN + T S+ D
Sbjct: 651 LQLHEH-----YKIHKEAVTGITVSRNGSSVFTTSQ-----------------------D 682
Query: 3544 NILRLKSKQSEPPVNFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSE 3603
+ L++ SK+S+ I S ++SC +P + T S + Y+ F
Sbjct: 683 STLKMFSKESKMLQRSISFSNM-ALSSCLLLPGDATVITSSWDNNVYFYSIAFG------ 735
Query: 3604 IEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTA 3663
Q L GH + ++ +C + L S S D T +W + H + A
Sbjct: 736 ---RRQDTLMGHDDAVSK--ICWHDNRLYSASWDSTVKVWS-GVPAEMPGTKRHHFDLLA 789
Query: 3664 VSASETSGD------IATVCDSAGGGSDLRLWTV-NGDLVGHVHCRE-IICSVAFSNQPE 3715
+ S D +T+ S + +W + L+ + C I+C AFS
Sbjct: 790 ELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSR 849
Query: 3716 GVSINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTV 3775
V L G + D++ I+ S++P F DG+ + + + G +
Sbjct: 850 HV--------LSTGTDGCLNVIDVQTGMLISSMTSDEP--QRCFVWDGNSVLSGSQSGEL 899
Query: 3776 IAW 3778
+ W
Sbjct: 900 LVW 902
>gi|239756689 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 1941
Score = 68.9 bits (167), Expect = 9e-11
Identities = 83/311 (26%), Positives = 122/311 (39%), Gaps = 54/311 (17%)
Query: 3135 WYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLSKPIA 3194
W G+I+NF YL LN+ AGR D +PV P+++ D+ + DL SK
Sbjct: 352 WVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV-DFTTPHGRFRDL----RKSK--- 403
Query: 3195 VQYKEKEDRYVD-TYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPF 3253
K D+ +D TY+ + + G PP P+H S+ T + R P
Sbjct: 404 -FRLNKGDKQLDFTYEMTRQAFVAGGAGGGE-PPHVPHHISDVLSDI-TYYVYKARRTPR 460
Query: 3254 TKM--FLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFD 3311
+ + + Q + + P N T E IPEF+ P
Sbjct: 461 SVLCGHVRAQWEPHEYPASMERMQNWT-----------PDECIPEFYTDPSIF------- 502
Query: 3312 FGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKAS 3371
R + +++P W + F+ HR LES VS+++ WIDL FGYK +GK +
Sbjct: 503 ---RSIHPDMPDLDVPAWCSSSQE-FVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEA 558
Query: 3372 VQAINVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGAKLNIEG 3431
V+ NV + T + +YG QLF H R +
Sbjct: 559 VKEKNVC----------------LHLVDAHTHLASYGVV--QLFDQPHPQRLAGAPALAP 600
Query: 3432 ELPAAVGLLVQ 3442
E P LLVQ
Sbjct: 601 EPPLIPKLLVQ 611
>gi|239751186 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 2240
Score = 68.9 bits (167), Expect = 9e-11
Identities = 83/311 (26%), Positives = 122/311 (39%), Gaps = 54/311 (17%)
Query: 3135 WYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLSKPIA 3194
W G+I+NF YL LN+ AGR D +PV P+++ D+ + DL SK
Sbjct: 651 WVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV-DFTTPHGRFRDL----RKSK--- 702
Query: 3195 VQYKEKEDRYVD-TYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPF 3253
K D+ +D TY+ + + G PP P+H S+ T + R P
Sbjct: 703 -FRLNKGDKQLDFTYEMTRQAFVAGGAGGGE-PPHVPHHISDVLSDI-TYYVYKARRTPR 759
Query: 3254 TKM--FLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFD 3311
+ + + Q + + P N T E IPEF+ P
Sbjct: 760 SVLCGHVRAQWEPHEYPASMERMQNWT-----------PDECIPEFYTDPSIF------- 801
Query: 3312 FGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKAS 3371
R + +++P W + F+ HR LES VS+++ WIDL FGYK +GK +
Sbjct: 802 ---RSIHPDMPDLDVPAWCSSSQE-FVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEA 857
Query: 3372 VQAINVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGAKLNIEG 3431
V+ NV + T + +YG QLF H R +
Sbjct: 858 VKEKNVC----------------LHLVDAHTHLASYGVV--QLFDQPHPQRLAGAPALAP 899
Query: 3432 ELPAAVGLLVQ 3442
E P LLVQ
Sbjct: 900 EPPLIPKLLVQ 910
>gi|239745674 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 1941
Score = 68.9 bits (167), Expect = 9e-11
Identities = 83/311 (26%), Positives = 122/311 (39%), Gaps = 54/311 (17%)
Query: 3135 WYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLSKPIA 3194
W G+I+NF YL LN+ AGR D +PV P+++ D+ + DL SK
Sbjct: 352 WVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV-DFTTPHGRFRDL----RKSK--- 403
Query: 3195 VQYKEKEDRYVD-TYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPF 3253
K D+ +D TY+ + + G PP P+H S+ T + R P
Sbjct: 404 -FRLNKGDKQLDFTYEMTRQAFVAGGAGGGE-PPHVPHHISDVLSDI-TYYVYKARRTPR 460
Query: 3254 TKM--FLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFD 3311
+ + + Q + + P N T E IPEF+ P
Sbjct: 461 SVLCGHVRAQWEPHEYPASMERMQNWT-----------PDECIPEFYTDPSIF------- 502
Query: 3312 FGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKAS 3371
R + +++P W + F+ HR LES VS+++ WIDL FGYK +GK +
Sbjct: 503 ---RSIHPDMPDLDVPAWCSSSQE-FVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEA 558
Query: 3372 VQAINVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGAKLNIEG 3431
V+ NV + T + +YG QLF H R +
Sbjct: 559 VKEKNVC----------------LHLVDAHTHLASYGVV--QLFDQPHPQRLAGAPALAP 600
Query: 3432 ELPAAVGLLVQ 3442
E P LLVQ
Sbjct: 601 EPPLIPKLLVQ 611
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 62.0 bits (149), Expect = 1e-08
Identities = 52/182 (28%), Positives = 83/182 (45%), Gaps = 22/182 (12%)
Query: 3612 LYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSG 3671
L GHT+++TS+ ++ S S D T IW + VQ + H+S VT +S T
Sbjct: 260 LKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATG- 318
Query: 3672 DIATVCDSAGGGSDLRLWTVNGDLVGHVHCREII----CSVAFSN-QPEGVSINVIAGGL 3726
D SD + W + G V + CS+ + P+G+ + G
Sbjct: 319 ------DYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGL---IFGTGT 369
Query: 3727 ENGIVRLWSTWDLKPVREI-TFPKSNKPIISLTFSCDGHHLYTANSDGTVIAWCRKDQQR 3785
+ +++ WDLK + FP + PI S+ FS +G++L TA D +V W D ++
Sbjct: 370 MDSQIKI---WDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLW---DLRK 423
Query: 3786 LK 3787
LK
Sbjct: 424 LK 425
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 59.3 bits (142), Expect = 7e-08
Identities = 68/272 (25%), Positives = 107/272 (39%), Gaps = 38/272 (13%)
Query: 3510 NFCLLMTYSKEQGVRSMNSTDIQWSAILSWGYADNILRLKSKQSEPPVNFIQSSQQYQVT 3569
+ C + QG+ +++ TD S++++ G+AD+ +R+ S + + Q+S
Sbjct: 460 SICFYTFLNAYQGLTAVDVTDD--SSLIAGGFADSTVRVWSVTPKKLRSVKQASD----- 512
Query: 3570 SCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYGHTEEITSLFVCKPYS 3629
L V+ + T SE+++ LYGH+ + +
Sbjct: 513 --------LSLIDKESDDVLERIMDE---KTASELKI-----LYGHSGPVYGASFSPDRN 556
Query: 3630 ILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGGGSDLRLW 3689
L+S S DGT +W L + GH PV S S G RLW
Sbjct: 557 YLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFV----SGGHDRVARLW 612
Query: 3690 TVNGDLVGHV---HCREIICSVAFSNQPEGVSINVIAGGLENGIVRLWSTWDLKPVREIT 3746
+ + H ++ C+ N N +A G + VRLW + VR T
Sbjct: 613 ATDHYQPLRIFAGHLADVNCTRFHPNS------NYVATGSADRTVRLWDVLNGNCVRIFT 666
Query: 3747 FPKSNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
K PI SLTFS +G L T +DG V+ W
Sbjct: 667 GHKG--PIHSLTFSPNGRFLATGATDGRVLLW 696
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 58.9 bits (141), Expect = 9e-08
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 18/172 (10%)
Query: 3612 LYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSG 3671
L H +T++ + K S I+ S D TC +WD + +L GH++ V A++ + G
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147
Query: 3672 D-IATVCDSAGGGSDLRLWTVNGDLVGHV---HCREIICSVAFSNQPEGVSINVIAGGLE 3727
D IAT +LW+V H H EI+C ++F+ Q ++A G
Sbjct: 148 DKIAT----GSFDKTCKLWSVETGKCYHTFRGHTAEIVC-LSFNPQS-----TLVATGSM 197
Query: 3728 NGIVRLWSTWDLKPVREI-TFPKSNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
+ +L WD++ E+ T + IISL+F+ G + T + D TV+ W
Sbjct: 198 DTTAKL---WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
Score = 43.5 bits (101), Expect = 0.004
Identities = 49/181 (27%), Positives = 79/181 (43%), Gaps = 19/181 (10%)
Query: 3612 LYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSG 3671
L GH+ EI SL +I+ S D T ++WD + V L GH + +++ S +
Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS 274
Query: 3672 DIATVCDSAGGGSD--LRLW-TVNGDLVGHV--HCREIICSVAFSNQPEGVSINVIAGGL 3726
I T G D +LW NG V + H EI+ S + +IA
Sbjct: 275 LILT------GSMDKTCKLWDATNGKCVATLTGHDDEILDSCF------DYTGKLIATAS 322
Query: 3727 ENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAWCRKDQQRL 3786
+G R++S K + ++ + I ++F+ G+HL T +SD T W + Q L
Sbjct: 323 ADGTARIFSAATRKCIAKLEGHEGE--ISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380
Query: 3787 K 3787
+
Sbjct: 381 Q 381
Score = 37.4 bits (85), Expect = 0.29
Identities = 42/172 (24%), Positives = 67/172 (38%), Gaps = 19/172 (11%)
Query: 3612 LYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSG 3671
L GH EI+S S++++ S D TC +WD V +L GH + T
Sbjct: 257 LIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK 316
Query: 3672 DIATVCDSAGGGSDLRLWTVN-----GDLVGHVHCREIICSVAFSNQPEGVSINVIAGGL 3726
IAT A R+++ L GH I ++F+ P+G N + G
Sbjct: 317 LIAT----ASADGTARIFSAATRKCIAKLEGH---EGEISKISFN--PQG---NHLLTGS 364
Query: 3727 ENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
+ R+W + ++ I S F+ G+ + T + D T W
Sbjct: 365 SDKTARIWDAQTGQCLQ--VLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 53.1 bits (126), Expect = 5e-06
Identities = 57/219 (26%), Positives = 87/219 (39%), Gaps = 35/219 (15%)
Query: 3568 VTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMET-QIHLYGHTEEITSLFVCK 3626
V SC W CG A ++ +S ++ E + LYGHT+ + S+
Sbjct: 439 VWSCTW----------HSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFP 488
Query: 3627 PYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGGGSDL 3686
+ L++ S D T IWD QSL GH + + + G + CD+ G
Sbjct: 489 FSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSIND-AIFDPRGHMIASCDACG---VT 544
Query: 3687 RLWTVNGDLVGHVHCREIICSVAFSNQPE-GVSIN------VIAGGLENGIVRLWSTWDL 3739
+LW R+++ V+ P G +N V+A NG++ L DL
Sbjct: 545 KLWDF----------RKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHL---LDL 591
Query: 3740 KPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
K ++ FS DG L++ SDGTV W
Sbjct: 592 KSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit isoform
a [Homo sapiens]
Length = 353
Score = 52.8 bits (125), Expect = 7e-06
Identities = 58/223 (26%), Positives = 93/223 (41%), Gaps = 32/223 (14%)
Query: 3568 VTSCAWVPDSCQLFTG---SKCGV--ITAYTNRFTSSTPSEIEMETQIHLYGHTEEITSL 3622
V +CA+ P C + G +KC V +T N ++ + M HT +++
Sbjct: 108 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAM--------HTNYLSAC 159
Query: 3623 FVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTA--VSASETSGD-IATVCDS 3679
+++ S DGTC +WD+ +QS GH + V ++ SET ++ CD
Sbjct: 160 SFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDK 219
Query: 3680 AGGGSDLRLWTVNGDLVGHVHCREI-ICSVAFSNQPEGVSINVIAGGLENGIVRLWSTWD 3738
D+R +G V E I SV + P G + A G ++ RL +D
Sbjct: 220 KAMVWDMR----SGQCVQAFETHESDINSVRY--YPSG---DAFASGSDDATCRL---YD 267
Query: 3739 LKPVREITFPKSNKPII---SLTFSCDGHHLYTANSDGTVIAW 3778
L+ RE+ I S+ FS G L+ +D T+ W
Sbjct: 268 LRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVW 310
Score = 32.3 bits (72), Expect = 9.2
Identities = 14/39 (35%), Positives = 23/39 (58%)
Query: 3606 METQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWD 3644
M+T+ L GH ++ + CK ++S S+DG I+WD
Sbjct: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 91
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 52.8 bits (125), Expect = 7e-06
Identities = 58/223 (26%), Positives = 93/223 (41%), Gaps = 32/223 (14%)
Query: 3568 VTSCAWVPDSCQLFTG---SKCGV--ITAYTNRFTSSTPSEIEMETQIHLYGHTEEITSL 3622
V +CA+ P C + G +KC V +T N ++ + M HT +++
Sbjct: 150 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAM--------HTNYLSAC 201
Query: 3623 FVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTA--VSASETSGD-IATVCDS 3679
+++ S DGTC +WD+ +QS GH + V ++ SET ++ CD
Sbjct: 202 SFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDK 261
Query: 3680 AGGGSDLRLWTVNGDLVGHVHCREI-ICSVAFSNQPEGVSINVIAGGLENGIVRLWSTWD 3738
D+R +G V E I SV + P G + A G ++ RL +D
Sbjct: 262 KAMVWDMR----SGQCVQAFETHESDINSVRY--YPSG---DAFASGSDDATCRL---YD 309
Query: 3739 LKPVREITFPKSNKPII---SLTFSCDGHHLYTANSDGTVIAW 3778
L+ RE+ I S+ FS G L+ +D T+ W
Sbjct: 310 LRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVW 352
Score = 32.3 bits (72), Expect = 9.2
Identities = 14/39 (35%), Positives = 23/39 (58%)
Query: 3606 METQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWD 3644
M+T+ L GH ++ + CK ++S S+DG I+WD
Sbjct: 95 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 133
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 52.0 bits (123), Expect = 1e-05
Identities = 60/218 (27%), Positives = 87/218 (39%), Gaps = 28/218 (12%)
Query: 3567 QVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYGHTEEITSLFVCK 3626
+V S A+ PD L TGS+ G + + R + L GHT +
Sbjct: 23 EVNSSAFSPDGQMLLTGSEDGCVYGWETR---------SGQLLWRLGGHTGPVKFCRFSP 73
Query: 3627 PYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGGGSDL 3686
+ S S D T +WD+ R ++ L GH+ V VS S S +A S G +
Sbjct: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLA----SGGWDKRV 129
Query: 3687 RLWTVNGD-----LVGHVHCREIICSVAFSNQPEGVSINVIAGGLENGIVRLWSTWDLKP 3741
LW V LVGH R+ I S FS ++N +A G + V +W + P
Sbjct: 130 MLWDVQSGQMLRLLVGH---RDSIQSSDFS-----PTVNCLATGSWDSTVHIWDLRMVTP 181
Query: 3742 -VREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
V + I L +S G L + + D T+ W
Sbjct: 182 AVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIW 218
>gi|209969680 Fzr1 protein isoform 1 [Homo sapiens]
Length = 496
Score = 50.8 bits (120), Expect = 3e-05
Identities = 52/215 (24%), Positives = 93/215 (43%), Gaps = 20/215 (9%)
Query: 3567 QVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYGHTEEITSLFVCK 3626
+V + AW + QL +GS+ +I R TP ++++ L GH +E+ L
Sbjct: 273 RVGALAWNAE--QLSSGSRDRMILQRDIR----TPP---LQSERRLQGHRQEVCGLKWST 323
Query: 3627 PYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGGGSD- 3685
+ +L S D ++W+ + L VQ H + V A++ S + S GG +D
Sbjct: 324 DHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLA---SGGGTADR 380
Query: 3686 -LRLW-TVNGDLVGHVHCREIICSVAFSNQPEGVSINVIAGGLENGIVRLWSTWDLKPVR 3743
+R W T+ G + + +C++A+S + V G + +W L V
Sbjct: 381 CIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANEL---VSTHGYSQNQILVWKYPSLTQVA 437
Query: 3744 EITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
++T + ++ L S DG + T D T+ W
Sbjct: 438 KLT--GHSYRVLYLAMSPDGEAIVTGAGDETLRFW 470
>gi|209969678 Fzr1 protein isoform 3 [Homo sapiens]
Length = 404
Score = 50.8 bits (120), Expect = 3e-05
Identities = 52/215 (24%), Positives = 93/215 (43%), Gaps = 20/215 (9%)
Query: 3567 QVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYGHTEEITSLFVCK 3626
+V + AW + QL +GS+ +I R TP ++++ L GH +E+ L
Sbjct: 184 RVGALAWNAE--QLSSGSRDRMILQRDIR----TPP---LQSERRLQGHRQEVCGLKWST 234
Query: 3627 PYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGGGSD- 3685
+ +L S D ++W+ + L VQ H + V A++ S + S GG +D
Sbjct: 235 DHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLA---SGGGTADR 291
Query: 3686 -LRLW-TVNGDLVGHVHCREIICSVAFSNQPEGVSINVIAGGLENGIVRLWSTWDLKPVR 3743
+R W T+ G + + +C++A+S + V G + +W L V
Sbjct: 292 CIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANEL---VSTHGYSQNQILVWKYPSLTQVA 348
Query: 3744 EITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
++T + ++ L S DG + T D T+ W
Sbjct: 349 KLT--GHSYRVLYLAMSPDGEAIVTGAGDETLRFW 381
>gi|33620742 Fzr1 protein isoform 2 [Homo sapiens]
Length = 493
Score = 50.8 bits (120), Expect = 3e-05
Identities = 52/215 (24%), Positives = 93/215 (43%), Gaps = 20/215 (9%)
Query: 3567 QVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYGHTEEITSLFVCK 3626
+V + AW + QL +GS+ +I R TP ++++ L GH +E+ L
Sbjct: 273 RVGALAWNAE--QLSSGSRDRMILQRDIR----TPP---LQSERRLQGHRQEVCGLKWST 323
Query: 3627 PYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGGGSD- 3685
+ +L S D ++W+ + L VQ H + V A++ S + S GG +D
Sbjct: 324 DHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLA---SGGGTADR 380
Query: 3686 -LRLW-TVNGDLVGHVHCREIICSVAFSNQPEGVSINVIAGGLENGIVRLWSTWDLKPVR 3743
+R W T+ G + + +C++A+S + V G + +W L V
Sbjct: 381 CIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANEL---VSTHGYSQNQILVWKYPSLTQVA 437
Query: 3744 EITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
++T + ++ L S DG + T D T+ W
Sbjct: 438 KLT--GHSYRVLYLAMSPDGEAIVTGAGDETLRFW 470
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 50.4 bits (119), Expect = 3e-05
Identities = 49/164 (29%), Positives = 73/164 (44%), Gaps = 15/164 (9%)
Query: 3637 DGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGGGSDLRLW-TVNGDL 3695
DG +WDL C V H+ +T S +ATVC G L+LW TV G L
Sbjct: 1738 DGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVC----LGGCLKLWDTVRGQL 1793
Query: 3696 V-GHVHCREIICSVAFSNQPEGVSINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPI 3754
H + + + C VAF PEG VIA G G + + LK +++ P ++ I
Sbjct: 1794 AFQHTYPKSLNC-VAF--HPEG---QVIATGSWAGSISFFQVDGLKVTKDLGAPGAS--I 1845
Query: 3755 ISLTFSCDGHHLYTANSDGTVIAWCRKDQQRLKQ-PMFYSFLSS 3797
+L F+ G + D V W ++ RL P + F+++
Sbjct: 1846 RTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAA 1889
Score = 44.7 bits (104), Expect = 0.002
Identities = 36/149 (24%), Positives = 64/149 (42%), Gaps = 13/149 (8%)
Query: 3630 ILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGGGSDLRLW 3689
++++V DG +W +C +L GH PV A + SETSG + T A +RLW
Sbjct: 2210 LVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLT----ASEDGSVRLW 2265
Query: 3690 TVNGDLVGHVHCREIICSVAFSNQPEGVSINVIAGGLENGIVRLWSTWDLKPVREITFPK 3749
V + R A + P+G ++ G + G + LW + + + +
Sbjct: 2266 QVPKEADDTCIPRSSAAVTAVAWAPDG---SMAVSGNQAGELILW-----QEAKAVATAQ 2317
Query: 3750 SNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
+ I +L +S H + ++D + W
Sbjct: 2318 APGHIGALIWS-SAHTFFVLSADEKISEW 2345
Score = 42.7 bits (99), Expect = 0.007
Identities = 61/254 (24%), Positives = 100/254 (39%), Gaps = 53/254 (20%)
Query: 3568 VTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYG--HTEEITSLFVC 3625
V+ C++ D L TG + + + R T TP IH + H + +T
Sbjct: 2064 VSCCSFSTDGGSLATGGRDRSLLCWDVR-TPKTP------VLIHSFPACHRDWVTGCAWT 2116
Query: 3626 KPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASET---------------- 3669
K ++LIS S DG+ +WD + GH+S V+AV+A E
Sbjct: 2117 KD-NLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDH 2175
Query: 3670 -----------SGDI----ATVCDSAGG--GSDLRLWTVNGDLVGHVHCREIICS----V 3708
SG I A + A G GS+L + TV D + ++C +
Sbjct: 2176 QGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLL 2235
Query: 3709 AFSNQPEGVSINVIAG----GLENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGH 3764
S +++ +G E+G VRLW K + P+S+ + ++ ++ DG
Sbjct: 2236 GHSGPVRAAAVSETSGLMLTASEDGSVRLWQV--PKEADDTCIPRSSAAVTAVAWAPDGS 2293
Query: 3765 HLYTANSDGTVIAW 3778
+ N G +I W
Sbjct: 2294 MAVSGNQAGELILW 2307
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 50.1 bits (118), Expect = 4e-05
Identities = 49/181 (27%), Positives = 74/181 (40%), Gaps = 19/181 (10%)
Query: 3612 LYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSG 3671
L GHTE ++S+ L S S D IIW Y ++L GH ++ V+ S S
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
Query: 3672 DIATVCDSAGGGSDLRLWTVNG-----DLVGHVHCREIICSVAFSNQPEGVSINVIAGGL 3726
+ SA L+LW V L G H + C N P N+I G
Sbjct: 97 RLV----SASDDKTLKLWDVRSGKCLKTLKG--HSNYVFC--CNFNPPS----NLIISGS 144
Query: 3727 ENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAWCRKDQQRL 3786
+ V++W K ++ T + P+ ++ F+C G + + + DG W Q L
Sbjct: 145 FDETVKIWEVKTGKCLK--TLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCL 202
Query: 3787 K 3787
K
Sbjct: 203 K 203
Score = 49.7 bits (117), Expect = 6e-05
Identities = 42/168 (25%), Positives = 73/168 (43%), Gaps = 10/168 (5%)
Query: 3612 LYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSG 3671
LYGH EI+ + S L+S S D T +WD+ +++L GH + V + + S
Sbjct: 79 LYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSN 138
Query: 3672 DIATVCDSAGGGSDLRLWTV-NGDLVGHVHCREIICSVAFSNQPEGVSINVIAGGLENGI 3730
I S +++W V G + + S N S ++I G +G+
Sbjct: 139 LII----SGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFN----CSGSLIVSGSYDGL 190
Query: 3731 VRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
R+W + ++ + N P+ + FS +G ++ TA D T+ W
Sbjct: 191 CRIWDAASGQCLKTLV-DDDNPPVSFVKFSPNGKYILTATLDNTLKLW 237
Score = 33.5 bits (75), Expect = 4.1
Identities = 33/143 (23%), Positives = 56/143 (39%), Gaps = 29/143 (20%)
Query: 3555 PPVNFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYG 3614
PPV+F++ S + A + ++ +L+ S+ + YT G
Sbjct: 211 PPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT--------------------G 250
Query: 3615 HTEEITSLFVCKPYSI-----LISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASET 3669
H E +F +S+ ++S S D IW+L VQ L GH V + + T
Sbjct: 251 HKNEKYCIFA--NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPT 308
Query: 3670 SGDIATVCDSAGGGSDLRLWTVN 3692
IA+ + ++LW N
Sbjct: 309 ENLIASA--ALENDKTIKLWMSN 329
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 49.7 bits (117), Expect = 6e-05
Identities = 39/169 (23%), Positives = 80/169 (47%), Gaps = 13/169 (7%)
Query: 3612 LYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSG 3671
L GHT + S+ + P ++++ S+ G+ +WDL +++L GHK+ + ++
Sbjct: 59 LTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGE 118
Query: 3672 DIATVCDSAGGGSDLRLWTV--NGDLVGHVHCREIICSVAFSNQPEGVSINVIAGGLENG 3729
+A S ++++LW + G + + + + + FS P+G +A ++
Sbjct: 119 FVA----SGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFS--PDG---KWLASAADDH 169
Query: 3730 IVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
V+LW K + E FP P+ + F + + L + +SD T+ W
Sbjct: 170 TVKLWDLTAGKMMSE--FPGHTGPVNVVEFHPNEYLLASGSSDRTIRFW 216
Score = 47.8 bits (112), Expect = 2e-04
Identities = 45/173 (26%), Positives = 77/173 (44%), Gaps = 20/173 (11%)
Query: 3612 LYGHTEEITSLFVCKPYSILISVSRDGTCI-IWDLNRLCYVQSLAGHKSPVTAVSASETS 3670
+ H ++SL + K L++ D + +W +N+ + SL GH SPV +V + T
Sbjct: 16 IVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN-TP 74
Query: 3671 GDIATVCDSAGGGSDLRLWTVNG-----DLVGHVHCREIICSVAFSNQPEGVSINVIAGG 3725
++ +G +R+W + L+GH + ICS+ F P G +A G
Sbjct: 75 EELIVAGSQSG---SIRVWDLEAAKILRTLMGH---KANICSLDF--HPYG---EFVASG 123
Query: 3726 LENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
++ ++LW V + ++ + L FS DG L +A D TV W
Sbjct: 124 SQDTNIKLWDIRRKGCV--FRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLW 174
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 49.7 bits (117), Expect = 6e-05
Identities = 47/213 (22%), Positives = 89/213 (41%), Gaps = 20/213 (9%)
Query: 3579 QLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYGHTEEITSLFVCKPYSILISVSRDG 3638
+LFT + +I ++ P ME HT+ + + +C LIS S D
Sbjct: 44 RLFTAGRDSIIRIWSVNQHKQDPYIASMEH------HTDWVNDIVLCCNGKTLISASSDT 97
Query: 3639 TCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGGGSDLRLWTVNGDLVGH 3698
T +W+ ++ + +L HK V A++ ++ +A SAG + LW VN L
Sbjct: 98 TVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVA----SAGLDRQIFLWDVN-TLTAL 152
Query: 3699 VHCREIICSVAFSNQPEGV---SIN----VIAGGLENGIVRLWSTWDLKPVREITFPKSN 3751
+ + + S + + ++N +I G ++R+W + ++ N
Sbjct: 153 TASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDN 212
Query: 3752 KPIISLTFSCDGHHLYTANSDGTVIAWCRKDQQ 3784
+ +L + DG + +SDGT+ W Q+
Sbjct: 213 --VKALLLNRDGTQCLSGSSDGTIRLWSLGQQR 243
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 48.1 bits (113), Expect = 2e-04
Identities = 48/193 (24%), Positives = 82/193 (42%), Gaps = 19/193 (9%)
Query: 3600 TPSEIEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKS 3659
TP + + L GHT+ ++S+ L S S D IW + ++++GHK
Sbjct: 29 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL 88
Query: 3660 PVTAVSASETSGDIATVCDSAGGGSDLRLWTVNG-----DLVGHVHCREIICSVAFSNQP 3714
++ V+ S S + SA L++W V+ L GH + F+ Q
Sbjct: 89 GISDVAWSSDSNLLV----SASDDKTLKIWDVSSGKCLKTLKGH---SNYVFCCNFNPQS 141
Query: 3715 EGVSINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGT 3774
N+I G + VR+W K ++ T P + P+ ++ F+ DG + +++ DG
Sbjct: 142 -----NLIVSGSFDESVRIWDVKTGKCLK--TLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194
Query: 3775 VIAWCRKDQQRLK 3787
W Q LK
Sbjct: 195 CRIWDTASGQCLK 207
Score = 43.5 bits (101), Expect = 0.004
Identities = 40/169 (23%), Positives = 72/169 (42%), Gaps = 16/169 (9%)
Query: 3614 GHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDI 3673
GH I+ + ++L+S S D T IWD++ +++L GH + V + + S I
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144
Query: 3674 ATVCDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGVSIN----VIAGGLENG 3729
S +R+W V C + + A S+ V N +I +G
Sbjct: 145 V----SGSFDESVRIWDVKTG-----KCLKTL--PAHSDPVSAVHFNRDGSLIVSSSYDG 193
Query: 3730 IVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
+ R+W T + ++ + N P+ + FS +G ++ A D T+ W
Sbjct: 194 LCRIWDTASGQCLKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 34.3 bits (77), Expect = 2.4
Identities = 33/140 (23%), Positives = 55/140 (39%), Gaps = 29/140 (20%)
Query: 3555 PPVNFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYG 3614
PPV+F++ S + A + ++ +L+ SK + YT G
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT--------------------G 254
Query: 3615 HTEEITSLFVCKPYSI-----LISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASET 3669
H E +F +S+ ++S S D IW+L VQ L GH V + + T
Sbjct: 255 HKNEKYCIFA--NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312
Query: 3670 SGDIATVCDSAGGGSDLRLW 3689
IA+ + ++LW
Sbjct: 313 ENIIASA--ALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 48.1 bits (113), Expect = 2e-04
Identities = 48/193 (24%), Positives = 82/193 (42%), Gaps = 19/193 (9%)
Query: 3600 TPSEIEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKS 3659
TP + + L GHT+ ++S+ L S S D IW + ++++GHK
Sbjct: 29 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL 88
Query: 3660 PVTAVSASETSGDIATVCDSAGGGSDLRLWTVNG-----DLVGHVHCREIICSVAFSNQP 3714
++ V+ S S + SA L++W V+ L GH + F+ Q
Sbjct: 89 GISDVAWSSDSNLLV----SASDDKTLKIWDVSSGKCLKTLKGH---SNYVFCCNFNPQS 141
Query: 3715 EGVSINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGT 3774
N+I G + VR+W K ++ T P + P+ ++ F+ DG + +++ DG
Sbjct: 142 -----NLIVSGSFDESVRIWDVKTGKCLK--TLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194
Query: 3775 VIAWCRKDQQRLK 3787
W Q LK
Sbjct: 195 CRIWDTASGQCLK 207
Score = 43.5 bits (101), Expect = 0.004
Identities = 40/169 (23%), Positives = 72/169 (42%), Gaps = 16/169 (9%)
Query: 3614 GHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASETSGDI 3673
GH I+ + ++L+S S D T IWD++ +++L GH + V + + S I
Sbjct: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144
Query: 3674 ATVCDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGVSIN----VIAGGLENG 3729
S +R+W V C + + A S+ V N +I +G
Sbjct: 145 V----SGSFDESVRIWDVKTG-----KCLKTL--PAHSDPVSAVHFNRDGSLIVSSSYDG 193
Query: 3730 IVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDGTVIAW 3778
+ R+W T + ++ + N P+ + FS +G ++ A D T+ W
Sbjct: 194 LCRIWDTASGQCLKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 34.3 bits (77), Expect = 2.4
Identities = 33/140 (23%), Positives = 55/140 (39%), Gaps = 29/140 (20%)
Query: 3555 PPVNFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPSEIEMETQIHLYG 3614
PPV+F++ S + A + ++ +L+ SK + YT G
Sbjct: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT--------------------G 254
Query: 3615 HTEEITSLFVCKPYSI-----LISVSRDGTCIIWDLNRLCYVQSLAGHKSPVTAVSASET 3669
H E +F +S+ ++S S D IW+L VQ L GH V + + T
Sbjct: 255 HKNEKYCIFA--NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312
Query: 3670 SGDIATVCDSAGGGSDLRLW 3689
IA+ + ++LW
Sbjct: 313 ENIIASA--ALENDKTIKLW 330
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 141,702,664
Number of Sequences: 37866
Number of extensions: 6382752
Number of successful extensions: 18651
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 164
Number of HSP's that attempted gapping in prelim test: 17855
Number of HSP's gapped (non-prelim): 771
length of query: 3801
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3679
effective length of database: 13,627,866
effective search space: 50136919014
effective search space used: 50136919014
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.