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Search of human proteins with 54234024
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54234024 vacuolar protein sorting 39 [Homo sapiens]
(875 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54234024 vacuolar protein sorting 39 [Homo sapiens] 1771 0.0
gi|217330589 transforming growth factor, beta receptor associate... 212 1e-54
gi|21359865 transforming growth factor, beta receptor associated... 212 1e-54
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 48 5e-05
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 47 1e-04
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 47 1e-04
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 47 1e-04
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 47 1e-04
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 47 1e-04
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 47 1e-04
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 47 1e-04
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 47 1e-04
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 45 4e-04
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 45 4e-04
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 45 4e-04
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 45 4e-04
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 44 9e-04
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 44 9e-04
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 42 0.003
gi|157671919 hypothetical protein LOC374864 isoform 1 [Homo sapi... 39 0.016
gi|157671917 hypothetical protein LOC374864 isoform 2 [Homo sapi... 39 0.016
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 39 0.021
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s... 39 0.021
gi|20357504 dystonin isoform 1eB precursor [Homo sapiens] 35 0.30
gi|22027627 TNF receptor-associated factor 5 [Homo sapiens] 35 0.30
gi|77404348 TNF receptor-associated factor 5 [Homo sapiens] 35 0.30
gi|11321603 TNF receptor-associated factor 5 [Homo sapiens] 35 0.30
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 34 0.52
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 32 2.6
gi|224591408 SH2 domain containing 4B isoform 2 [Homo sapiens] 31 4.4
>gi|54234024 vacuolar protein sorting 39 [Homo sapiens]
Length = 875
Score = 1771 bits (4586), Expect = 0.0
Identities = 875/875 (100%), Positives = 875/875 (100%)
Query: 1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNK 60
MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNK
Sbjct: 1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNK 60
Query: 61 NFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGE 120
NFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGE
Sbjct: 61 NFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGE 120
Query: 121 EVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVD 180
EVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVD
Sbjct: 121 EVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVD 180
Query: 181 GKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAME 240
GKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAME
Sbjct: 181 GKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAME 240
Query: 241 HQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPM 300
HQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPM
Sbjct: 241 HQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPM 300
Query: 301 ATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAK 360
ATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAK
Sbjct: 301 ATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAK 360
Query: 361 LGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKL 420
LGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKL
Sbjct: 361 LGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKL 420
Query: 421 NDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEE 480
NDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEE
Sbjct: 421 NDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEE 480
Query: 481 SEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENL 540
SEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENL
Sbjct: 481 SEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENL 540
Query: 541 HLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVW 600
HLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVW
Sbjct: 541 HLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVW 600
Query: 601 EETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEIS 660
EETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEIS
Sbjct: 601 EETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEIS 660
Query: 661 SYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNK 720
SYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNK
Sbjct: 661 SYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNK 720
Query: 721 DGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLL 780
DGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLL
Sbjct: 721 DGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLL 780
Query: 781 PANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKV 840
PANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKV
Sbjct: 781 PANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKV 840
Query: 841 CMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT 875
CMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT
Sbjct: 841 CMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT 875
>gi|217330589 transforming growth factor, beta receptor associated
protein 1 [Homo sapiens]
Length = 860
Score = 212 bits (540), Expect = 1e-54
Identities = 221/884 (25%), Positives = 397/884 (44%), Gaps = 70/884 (7%)
Query: 12 EKLPLQIDCLAAWEEWLLVGTKQG---HLLLYRIRKDVGCNRFEVTLE-KSNKNFSKKIQ 67
+K + I+C+ L VGT H LL G F T + + + F K +
Sbjct: 21 DKERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVN 80
Query: 68 QIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRMCV 127
++ S L+ L +N+I + ++L + + + ++ KGA+ F + + +C+
Sbjct: 81 ELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGDPFCVEVCI 140
Query: 128 -AVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGSIK 186
+VK++ F + ++ + S + P ++A + +C+ Y +I G +
Sbjct: 141 ISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFLCLALTTQY-IIHNYSTGVSQ 199
Query: 187 ELFP-TGKQLEPLVAPLADGK-VAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPP 244
+LFP ++ P+V + + + G L + GI +Q+ ++W++ + P
Sbjct: 200 DLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATVAGI-SQRAPVHWSENVIGAAVSFP 258
Query: 245 YIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQI 304
Y+IA+ ++ + + + Q++ + + +I VA++ V+ L+P+P+ QI
Sbjct: 259 YVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVI-VATSKGVYILVPLPLEKQI 317
Query: 305 QQLLQDKQFELALQLAE-MKDDSDSEKQQQIHH-IKNLYAFNLFCQKRFDESMQVFAKLG 362
Q LL ++ E AL LA+ + + EK Q ++ I F F Q +F E+ ++F
Sbjct: 318 QDLLASRRVEEALVLAKGARRNIPKEKFQVMYRRILQQAGFIQFAQLQFLEAKELFRSGQ 377
Query: 363 TDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLND 422
D ++ LYP LLPT +P P+ A+L + + + + + L+ LN+
Sbjct: 378 LDVRELISLYPFLLPTSSSFTRSHP---PLHEYADLNQLTQGDQEKMAKCKRFLMSYLNE 434
Query: 423 SDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESE 482
+ T K + IDT LLK Y + + LL EN C + +S
Sbjct: 435 ----------VRSTEVANGYK---EDIDTALLKLYAEADHDSLLDLLVTEN-FCLLTDSA 480
Query: 483 HVLKKAHKYSELIILYEKKGLHEKALQVLV-----DQSKKANSPLKGHERTVQYLQHLGT 537
L+K KY L +LY A+Q+ V D S L +E V +L +
Sbjct: 481 AWLEKHKKYFALGLLYHYNNQDAAAVQLWVNIVNGDVQDSTRSDL--YEYIVDFLTYCLD 538
Query: 538 ENLHLIFSYSVWVLRDFPEDGLKIFTE---DLPEVESLPRDRVLGFLIENFKGLAIPYLE 594
E L +++Y+ WVL+ E G+++FT+ D + S D ++ L + K L + YLE
Sbjct: 539 EEL--VWAYADWVLQKSEEVGVQVFTKRPLDEQQKNSFNPDDIINCLKKYPKAL-VKYLE 595
Query: 595 HIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLL 654
H++ +H L LY E+V L++ A + E E + KL
Sbjct: 596 HLVIDKRLQKEEYHTHLAVLYLEEV--LLQR-----------ASASGKGAEATETQAKLR 642
Query: 655 MFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHK 714
L+ S Y L+ GL E A+L G++G+HE+AL I VH L+D AE+YC
Sbjct: 643 RLLQKSDLYRVHFLLERLQGAGLPMESAILHGKLGEHEKALHILVHELQDFAAAEDYCLW 702
Query: 715 HYD-RNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDT 773
+ R+ + ++ +LL +YL GP EL AA+ +L H ++ D
Sbjct: 703 CSEGRDPPHRQQLFHTLLAIYLHA------GPTAHELAV------AAVDLLNRHATEFDA 750
Query: 774 TKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKC 833
+ L +LP + + FL + ++ +R QV L +E L +++ +
Sbjct: 751 AQVLQMLPDTWSVQLLCPFLMGAMRDSIHARRTMQVALGLARSENLIYTYDKMKLKGSSI 810
Query: 834 IITEEKVCMVCKKKIGNSAFARYPNGVVVHYFC--SKEVNPADT 875
++++K+C +C+ F RYPNG +VH C S+ NP+ +
Sbjct: 811 QLSDKKLCQICQNPFCEPVFVRYPNGGLVHTHCAASRHTNPSSS 854
>gi|21359865 transforming growth factor, beta receptor associated
protein 1 [Homo sapiens]
Length = 860
Score = 212 bits (540), Expect = 1e-54
Identities = 221/884 (25%), Positives = 397/884 (44%), Gaps = 70/884 (7%)
Query: 12 EKLPLQIDCLAAWEEWLLVGTKQG---HLLLYRIRKDVGCNRFEVTLE-KSNKNFSKKIQ 67
+K + I+C+ L VGT H LL G F T + + + F K +
Sbjct: 21 DKERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVN 80
Query: 68 QIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRMCV 127
++ S L+ L +N+I + ++L + + + ++ KGA+ F + + +C+
Sbjct: 81 ELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGDPFCVEVCI 140
Query: 128 -AVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKGSIK 186
+VK++ F + ++ + S + P ++A + +C+ Y +I G +
Sbjct: 141 ISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFLCLALTTQY-IIHNYSTGVSQ 199
Query: 187 ELFP-TGKQLEPLVAPLADGK-VAVGQDDLTVVLNEEGICTQKCALNWTDIPVAMEHQPP 244
+LFP ++ P+V + + + G L + GI +Q+ ++W++ + P
Sbjct: 200 DLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATVAGI-SQRAPVHWSENVIGAAVSFP 258
Query: 245 YIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPMATQI 304
Y+IA+ ++ + + + Q++ + + +I VA++ V+ L+P+P+ QI
Sbjct: 259 YVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVI-VATSKGVYILVPLPLEKQI 317
Query: 305 QQLLQDKQFELALQLAE-MKDDSDSEKQQQIHH-IKNLYAFNLFCQKRFDESMQVFAKLG 362
Q LL ++ E AL LA+ + + EK Q ++ I F F Q +F E+ ++F
Sbjct: 318 QDLLASRRVEEALVLAKGARRNIPKEKFQVMYRRILQQAGFIQFAQLQFLEAKELFRSGQ 377
Query: 363 TDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLND 422
D ++ LYP LLPT +P P+ A+L + + + + + L+ LN+
Sbjct: 378 LDVRELISLYPFLLPTSSSFTRSHP---PLHEYADLNQLTQGDQEKMAKCKRFLMSYLNE 434
Query: 423 SDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESE 482
+ T K + IDT LLK Y + + LL EN C + +S
Sbjct: 435 ----------VRSTEVANGYK---EDIDTALLKLYAEADHDSLLDLLVTEN-FCLLTDSA 480
Query: 483 HVLKKAHKYSELIILYEKKGLHEKALQVLV-----DQSKKANSPLKGHERTVQYLQHLGT 537
L+K KY L +LY A+Q+ V D S L +E V +L +
Sbjct: 481 AWLEKHKKYFALGLLYHYNNQDAAAVQLWVNIVNGDVQDSTRSDL--YEYIVDFLTYCLD 538
Query: 538 ENLHLIFSYSVWVLRDFPEDGLKIFTE---DLPEVESLPRDRVLGFLIENFKGLAIPYLE 594
E L +++Y+ WVL+ E G+++FT+ D + S D ++ L + K L + YLE
Sbjct: 539 EEL--VWAYADWVLQKSEEVGVQVFTKRPLDEQQKNSFNPDDIINCLKKYPKAL-VKYLE 595
Query: 595 HIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLL 654
H++ +H L LY E+V L++ A + E E + KL
Sbjct: 596 HLVIDKRLQKEEYHTHLAVLYLEEV--LLQR-----------ASASGKGAEATETQAKLR 642
Query: 655 MFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHK 714
L+ S Y L+ GL E A+L G++G+HE+AL I VH L+D AE+YC
Sbjct: 643 RLLQKSDLYRVHFLLERLQGAGLPMESAILHGKLGEHEKALHILVHELQDFAAAEDYCLW 702
Query: 715 HYD-RNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDT 773
+ R+ + ++ +LL +YL GP EL AA+ +L H ++ D
Sbjct: 703 CSEGRDPPHRQQLFHTLLAIYLHA------GPTAHELAV------AAVDLLNRHATEFDA 750
Query: 774 TKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKC 833
+ L +LP + + FL + ++ +R QV L +E L +++ +
Sbjct: 751 AQVLQMLPDTWSVQLLCPFLMGAMRDSIHARRTMQVALGLARSENLIYTYDKMKLKGSSI 810
Query: 834 IITEEKVCMVCKKKIGNSAFARYPNGVVVHYFC--SKEVNPADT 875
++++K+C +C+ F RYPNG +VH C S+ NP+ +
Sbjct: 811 QLSDKKLCQICQNPFCEPVFVRYPNGGLVHTHCAASRHTNPSSS 854
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 47.8 bits (112), Expect = 5e-05
Identities = 55/237 (23%), Positives = 95/237 (40%), Gaps = 23/237 (9%)
Query: 64 KKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGA------SLFTCDLQHTE 117
KK+ QI + + KI++ L N +VH +++ A+G+ C L T
Sbjct: 1279 KKVHQIELAPREKIVILLCGRNHHVH----LYPWSSLDGAEGSFDIKLPETKGCQLMATA 1334
Query: 118 TGEEVLRMC--VAVKKKLQLY-FWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDY 174
T + C VAVK+ + Y + + FH + P + +A + +CVG+ +
Sbjct: 1335 TLKRNSGTCLFVAVKRLILCYEIQRTKPFHRKFNEIVAPGSVQCLAVLRDRLCVGYPSGF 1394
Query: 175 YLIRVDGKGSIKELF-PTGKQLEPLVAPLADGKVAVGQDD---------LTVVLNEEGIC 224
L+ + G G L P L L D AV + + + ++ +G
Sbjct: 1395 CLLSIQGDGQPLNLVNPNDPSLAFLSQQSFDALCAVELESEEYLLCFSHMGLYVDPQGRR 1454
Query: 225 TQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGS 281
+ L W PVA P ++ V++ VQ+I L+R R + S G+
Sbjct: 1455 ARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTMEWVQTIGLRRIRPLNSEGT 1511
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 46.6 bits (109), Expect = 1e-04
Identities = 60/270 (22%), Positives = 110/270 (40%), Gaps = 36/270 (13%)
Query: 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNKNFSKKIQQIHVVSQFK 76
+I C A W LLVGT+ G +LL R + N ++ QQ+ V+
Sbjct: 957 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLIN----------RRRFQQMDVLEGLN 1006
Query: 77 ILVSL--LENNIYVHDL-----LTFQQITTVSKAKG----ASLFTCDLQHTETGEEVLRM 125
+LV++ +N + V+ L V K +G L C E + +
Sbjct: 1007 VLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFL 1066
Query: 126 CVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS--------ICVGFKRDYYLI 177
+A+K +++Y W + +H+ S D+ + + + G +++I
Sbjct: 1067 VIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVI 1126
Query: 178 RVDGKGSIKELFPTGKQ--LEP---LVAPLADG-KVAVGQDDLTVVLNEEGICTQKCALN 231
VD S P+ Q + P ++ P DG ++ V +D V +N G T+ L
Sbjct: 1127 DVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQ 1186
Query: 232 WTDIPVAMEH-QPPYIIAVLPRYVEIRTFE 260
W ++P ++ + I+ + +EIR+ E
Sbjct: 1187 WGEMPTSVAYIHSNQIMGWGEKAIEIRSVE 1216
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 46.6 bits (109), Expect = 1e-04
Identities = 60/270 (22%), Positives = 110/270 (40%), Gaps = 36/270 (13%)
Query: 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNKNFSKKIQQIHVVSQFK 76
+I C A W LLVGT+ G +LL R + N ++ QQ+ V+
Sbjct: 965 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLIN----------RRRFQQMDVLEGLN 1014
Query: 77 ILVSL--LENNIYVHDL-----LTFQQITTVSKAKG----ASLFTCDLQHTETGEEVLRM 125
+LV++ +N + V+ L V K +G L C E + +
Sbjct: 1015 VLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFL 1074
Query: 126 CVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS--------ICVGFKRDYYLI 177
+A+K +++Y W + +H+ S D+ + + + G +++I
Sbjct: 1075 VIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVI 1134
Query: 178 RVDGKGSIKELFPTGKQ--LEP---LVAPLADG-KVAVGQDDLTVVLNEEGICTQKCALN 231
VD S P+ Q + P ++ P DG ++ V +D V +N G T+ L
Sbjct: 1135 DVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQ 1194
Query: 232 WTDIPVAMEH-QPPYIIAVLPRYVEIRTFE 260
W ++P ++ + I+ + +EIR+ E
Sbjct: 1195 WGEMPTSVAYIHSNQIMGWGEKAIEIRSVE 1224
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 46.6 bits (109), Expect = 1e-04
Identities = 60/270 (22%), Positives = 110/270 (40%), Gaps = 36/270 (13%)
Query: 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNKNFSKKIQQIHVVSQFK 76
+I C A W LLVGT+ G +LL R + N ++ QQ+ V+
Sbjct: 986 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLIN----------RRRFQQMDVLEGLN 1035
Query: 77 ILVSL--LENNIYVHDL-----LTFQQITTVSKAKG----ASLFTCDLQHTETGEEVLRM 125
+LV++ +N + V+ L V K +G L C E + +
Sbjct: 1036 VLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFL 1095
Query: 126 CVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS--------ICVGFKRDYYLI 177
+A+K +++Y W + +H+ S D+ + + + G +++I
Sbjct: 1096 VIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVI 1155
Query: 178 RVDGKGSIKELFPTGKQ--LEP---LVAPLADG-KVAVGQDDLTVVLNEEGICTQKCALN 231
VD S P+ Q + P ++ P DG ++ V +D V +N G T+ L
Sbjct: 1156 DVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQ 1215
Query: 232 WTDIPVAMEH-QPPYIIAVLPRYVEIRTFE 260
W ++P ++ + I+ + +EIR+ E
Sbjct: 1216 WGEMPTSVAYIHSNQIMGWGEKAIEIRSVE 1245
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 46.6 bits (109), Expect = 1e-04
Identities = 60/270 (22%), Positives = 110/270 (40%), Gaps = 36/270 (13%)
Query: 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNKNFSKKIQQIHVVSQFK 76
+I C A W LLVGT+ G +LL R + N ++ QQ+ V+
Sbjct: 994 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLIN----------RRRFQQMDVLEGLN 1043
Query: 77 ILVSL--LENNIYVHDL-----LTFQQITTVSKAKG----ASLFTCDLQHTETGEEVLRM 125
+LV++ +N + V+ L V K +G L C E + +
Sbjct: 1044 VLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFL 1103
Query: 126 CVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS--------ICVGFKRDYYLI 177
+A+K +++Y W + +H+ S D+ + + + G +++I
Sbjct: 1104 VIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVI 1163
Query: 178 RVDGKGSIKELFPTGKQ--LEP---LVAPLADG-KVAVGQDDLTVVLNEEGICTQKCALN 231
VD S P+ Q + P ++ P DG ++ V +D V +N G T+ L
Sbjct: 1164 DVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQ 1223
Query: 232 WTDIPVAMEH-QPPYIIAVLPRYVEIRTFE 260
W ++P ++ + I+ + +EIR+ E
Sbjct: 1224 WGEMPTSVAYIHSNQIMGWGEKAIEIRSVE 1253
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 46.6 bits (109), Expect = 1e-04
Identities = 60/270 (22%), Positives = 110/270 (40%), Gaps = 36/270 (13%)
Query: 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNKNFSKKIQQIHVVSQFK 76
+I C A W LLVGT+ G +LL R + N ++ QQ+ V+
Sbjct: 1012 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLIN----------RRRFQQMDVLEGLN 1061
Query: 77 ILVSL--LENNIYVHDL-----LTFQQITTVSKAKG----ASLFTCDLQHTETGEEVLRM 125
+LV++ +N + V+ L V K +G L C E + +
Sbjct: 1062 VLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFL 1121
Query: 126 CVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS--------ICVGFKRDYYLI 177
+A+K +++Y W + +H+ S D+ + + + G +++I
Sbjct: 1122 VIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVI 1181
Query: 178 RVDGKGSIKELFPTGKQ--LEP---LVAPLADG-KVAVGQDDLTVVLNEEGICTQKCALN 231
VD S P+ Q + P ++ P DG ++ V +D V +N G T+ L
Sbjct: 1182 DVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQ 1241
Query: 232 WTDIPVAMEH-QPPYIIAVLPRYVEIRTFE 260
W ++P ++ + I+ + +EIR+ E
Sbjct: 1242 WGEMPTSVAYIHSNQIMGWGEKAIEIRSVE 1271
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 46.6 bits (109), Expect = 1e-04
Identities = 60/270 (22%), Positives = 110/270 (40%), Gaps = 36/270 (13%)
Query: 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNKNFSKKIQQIHVVSQFK 76
+I C A W LLVGT+ G +LL R + N ++ QQ+ V+
Sbjct: 1020 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLIN----------RRRFQQMDVLEGLN 1069
Query: 77 ILVSL--LENNIYVHDL-----LTFQQITTVSKAKG----ASLFTCDLQHTETGEEVLRM 125
+LV++ +N + V+ L V K +G L C E + +
Sbjct: 1070 VLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFL 1129
Query: 126 CVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS--------ICVGFKRDYYLI 177
+A+K +++Y W + +H+ S D+ + + + G +++I
Sbjct: 1130 VIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVI 1189
Query: 178 RVDGKGSIKELFPTGKQ--LEP---LVAPLADG-KVAVGQDDLTVVLNEEGICTQKCALN 231
VD S P+ Q + P ++ P DG ++ V +D V +N G T+ L
Sbjct: 1190 DVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQ 1249
Query: 232 WTDIPVAMEH-QPPYIIAVLPRYVEIRTFE 260
W ++P ++ + I+ + +EIR+ E
Sbjct: 1250 WGEMPTSVAYIHSNQIMGWGEKAIEIRSVE 1279
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 46.6 bits (109), Expect = 1e-04
Identities = 60/270 (22%), Positives = 110/270 (40%), Gaps = 36/270 (13%)
Query: 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNKNFSKKIQQIHVVSQFK 76
+I C A W LLVGT+ G +LL R + N ++ QQ+ V+
Sbjct: 1041 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLIN----------RRRFQQMDVLEGLN 1090
Query: 77 ILVSL--LENNIYVHDL-----LTFQQITTVSKAKG----ASLFTCDLQHTETGEEVLRM 125
+LV++ +N + V+ L V K +G L C E + +
Sbjct: 1091 VLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFL 1150
Query: 126 CVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS--------ICVGFKRDYYLI 177
+A+K +++Y W + +H+ S D+ + + + G +++I
Sbjct: 1151 VIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVI 1210
Query: 178 RVDGKGSIKELFPTGKQ--LEP---LVAPLADG-KVAVGQDDLTVVLNEEGICTQKCALN 231
VD S P+ Q + P ++ P DG ++ V +D V +N G T+ L
Sbjct: 1211 DVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQ 1270
Query: 232 WTDIPVAMEH-QPPYIIAVLPRYVEIRTFE 260
W ++P ++ + I+ + +EIR+ E
Sbjct: 1271 WGEMPTSVAYIHSNQIMGWGEKAIEIRSVE 1300
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens]
Length = 1360
Score = 46.6 bits (109), Expect = 1e-04
Identities = 60/270 (22%), Positives = 110/270 (40%), Gaps = 36/270 (13%)
Query: 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNKNFSKKIQQIHVVSQFK 76
+I C A W LLVGT+ G +LL R + N ++ QQ+ V+
Sbjct: 1049 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLIN----------RRRFQQMDVLEGLN 1098
Query: 77 ILVSL--LENNIYVHDL-----LTFQQITTVSKAKG----ASLFTCDLQHTETGEEVLRM 125
+LV++ +N + V+ L V K +G L C E + +
Sbjct: 1099 VLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFL 1158
Query: 126 CVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS--------ICVGFKRDYYLI 177
+A+K +++Y W + +H+ S D+ + + + G +++I
Sbjct: 1159 VIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVI 1218
Query: 178 RVDGKGSIKELFPTGKQ--LEP---LVAPLADG-KVAVGQDDLTVVLNEEGICTQKCALN 231
VD S P+ Q + P ++ P DG ++ V +D V +N G T+ L
Sbjct: 1219 DVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQ 1278
Query: 232 WTDIPVAMEH-QPPYIIAVLPRYVEIRTFE 260
W ++P ++ + I+ + +EIR+ E
Sbjct: 1279 WGEMPTSVAYIHSNQIMGWGEKAIEIRSVE 1308
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 44.7 bits (104), Expect = 4e-04
Identities = 59/250 (23%), Positives = 101/250 (40%), Gaps = 35/250 (14%)
Query: 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKD-----VGCNRFEV--TLEKSNK--NFSKKIQ 67
+I C A W LLVGT+ G +LL R + +G RF+ LE N S K
Sbjct: 1001 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1060
Query: 68 QIHVVSQFKILVSLLENNIYVHD--LLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRM 125
++ V +S L N I +D + Q TTV +G C E + +
Sbjct: 1061 KLRVY-----YLSWLRNKILHNDPEVEKKQGWTTVGDMEG-----CGHYRVVKYERIKFL 1110
Query: 126 CVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS--------ICVGFKRDYYLI 177
+A+K +++Y W + +H+ S D+P + + + G ++ +
Sbjct: 1111 VIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAV 1170
Query: 178 RVDGKGSIKELFPT--GKQLEP---LVAPLADG-KVAVGQDDLTVVLNEEGICTQKCALN 231
VD S P Q+ P + P DG ++ + +D V +N G + L
Sbjct: 1171 DVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQ 1230
Query: 232 WTDIPVAMEH 241
W ++P ++ +
Sbjct: 1231 WGEMPTSVAY 1240
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 44.7 bits (104), Expect = 4e-04
Identities = 59/250 (23%), Positives = 101/250 (40%), Gaps = 35/250 (14%)
Query: 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKD-----VGCNRFEV--TLEKSNK--NFSKKIQ 67
+I C A W LLVGT+ G +LL R + +G RF+ LE N S K
Sbjct: 992 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1051
Query: 68 QIHVVSQFKILVSLLENNIYVHD--LLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRM 125
++ V +S L N I +D + Q TTV +G C E + +
Sbjct: 1052 KLRVY-----YLSWLRNKILHNDPEVEKKQGWTTVGDMEG-----CGHYRVVKYERIKFL 1101
Query: 126 CVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS--------ICVGFKRDYYLI 177
+A+K +++Y W + +H+ S D+P + + + G ++ +
Sbjct: 1102 VIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAV 1161
Query: 178 RVDGKGSIKELFPT--GKQLEP---LVAPLADG-KVAVGQDDLTVVLNEEGICTQKCALN 231
VD S P Q+ P + P DG ++ + +D V +N G + L
Sbjct: 1162 DVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQ 1221
Query: 232 WTDIPVAMEH 241
W ++P ++ +
Sbjct: 1222 WGEMPTSVAY 1231
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 44.7 bits (104), Expect = 4e-04
Identities = 59/250 (23%), Positives = 101/250 (40%), Gaps = 35/250 (14%)
Query: 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKD-----VGCNRFEV--TLEKSNK--NFSKKIQ 67
+I C A W LLVGT+ G +LL R + +G RF+ LE N S K
Sbjct: 1021 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1080
Query: 68 QIHVVSQFKILVSLLENNIYVHD--LLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRM 125
++ V +S L N I +D + Q TTV +G C E + +
Sbjct: 1081 KLRVY-----YLSWLRNKILHNDPEVEKKQGWTTVGDMEG-----CGHYRVVKYERIKFL 1130
Query: 126 CVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS--------ICVGFKRDYYLI 177
+A+K +++Y W + +H+ S D+P + + + G ++ +
Sbjct: 1131 VIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAV 1190
Query: 178 RVDGKGSIKELFPT--GKQLEP---LVAPLADG-KVAVGQDDLTVVLNEEGICTQKCALN 231
VD S P Q+ P + P DG ++ + +D V +N G + L
Sbjct: 1191 DVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQ 1250
Query: 232 WTDIPVAMEH 241
W ++P ++ +
Sbjct: 1251 WGEMPTSVAY 1260
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 44.7 bits (104), Expect = 4e-04
Identities = 59/250 (23%), Positives = 101/250 (40%), Gaps = 35/250 (14%)
Query: 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKD-----VGCNRFEV--TLEKSNK--NFSKKIQ 67
+I C A W LLVGT+ G +LL R + +G RF+ LE N S K
Sbjct: 984 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1043
Query: 68 QIHVVSQFKILVSLLENNIYVHD--LLTFQQITTVSKAKGASLFTCDLQHTETGEEVLRM 125
++ V +S L N I +D + Q TTV +G C E + +
Sbjct: 1044 KLRVY-----YLSWLRNKILHNDPEVEKKQGWTTVGDMEG-----CGHYRVVKYERIKFL 1093
Query: 126 CVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENS--------ICVGFKRDYYLI 177
+A+K +++Y W + +H+ S D+P + + + G ++ +
Sbjct: 1094 VIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAV 1153
Query: 178 RVDGKGSIKELFPT--GKQLEP---LVAPLADG-KVAVGQDDLTVVLNEEGICTQKCALN 231
VD S P Q+ P + P DG ++ + +D V +N G + L
Sbjct: 1154 DVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQ 1213
Query: 232 WTDIPVAMEH 241
W ++P ++ +
Sbjct: 1214 WGEMPTSVAY 1223
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 43.5 bits (101), Expect = 9e-04
Identities = 59/260 (22%), Positives = 110/260 (42%), Gaps = 55/260 (21%)
Query: 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNKNFSKKIQQIHVVSQFK 76
+I C A W LLVGT+ G +LL R G + + + ++ QQ+ V+
Sbjct: 901 EILCAALWGVNLLVGTESGLMLLDR----SGQGKVYPLINR------RRFQQMDVLEGLN 950
Query: 77 ILVSL--------------LENNIYVHD--LLTFQQITTVSKAKGASLFTCDLQHTETGE 120
+LV++ L N I +D + Q TTV +G C E
Sbjct: 951 VLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEG-----CVHYKVVKYE 1005
Query: 121 EVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSI------------CV 168
+ + +A+K +++Y W + +H+ S ++ + ++ C
Sbjct: 1006 RIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCA 1065
Query: 169 GFKRDYYLIRVDGKGSIKELF-PTGKQ--LEP---LVAPLADG-KVAVGQDDLTVVLNEE 221
GF + + VD GS+ +++ PT Q ++P ++ P DG ++ V +D V +N
Sbjct: 1066 GF----HAVDVD-SGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTY 1120
Query: 222 GICTQKCALNWTDIPVAMEH 241
G T+ L W ++P ++ +
Sbjct: 1121 GRITKDVVLQWGEMPTSVAY 1140
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 43.5 bits (101), Expect = 9e-04
Identities = 59/260 (22%), Positives = 110/260 (42%), Gaps = 55/260 (21%)
Query: 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNKNFSKKIQQIHVVSQFK 76
+I C A W LLVGT+ G +LL R G + + + ++ QQ+ V+
Sbjct: 1009 EILCAALWGVNLLVGTESGLMLLDR----SGQGKVYPLINR------RRFQQMDVLEGLN 1058
Query: 77 ILVSL--------------LENNIYVHD--LLTFQQITTVSKAKGASLFTCDLQHTETGE 120
+LV++ L N I +D + Q TTV +G C E
Sbjct: 1059 VLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEG-----CVHYKVVKYE 1113
Query: 121 EVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSI------------CV 168
+ + +A+K +++Y W + +H+ S ++ + ++ C
Sbjct: 1114 RIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCA 1173
Query: 169 GFKRDYYLIRVDGKGSIKELF-PTGKQ--LEP---LVAPLADG-KVAVGQDDLTVVLNEE 221
GF + + VD GS+ +++ PT Q ++P ++ P DG ++ V +D V +N
Sbjct: 1174 GF----HAVDVD-SGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTY 1228
Query: 222 GICTQKCALNWTDIPVAMEH 241
G T+ L W ++P ++ +
Sbjct: 1229 GRITKDVVLQWGEMPTSVAY 1248
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 41.6 bits (96), Expect = 0.003
Identities = 58/268 (21%), Positives = 108/268 (40%), Gaps = 63/268 (23%)
Query: 17 QIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNKNFSKKIQQIHVVSQFK 76
+I C A W LLVGT+ G +LL R G + + + ++ QQ+ V+
Sbjct: 847 EILCAALWGVNLLVGTESGLMLLDR----SGQGKVYPLINR------RRFQQMDVLEGLN 896
Query: 77 ILVSL--------------LENNIYVHD--LLTFQQITTVSKAKGASLFTCDLQHTETGE 120
+LV++ L N I +D + Q TTV +G C E
Sbjct: 897 VLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEG-----CVHYKVVKYE 951
Query: 121 EVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSI------------CV 168
+ + +A+K +++Y W + +H+ S ++ + ++ C
Sbjct: 952 RIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCA 1011
Query: 169 GFKRDYYLIRVDGKGSIKELF-PTGKQLEP-------------LVAPLADG-KVAVGQDD 213
GF + + VD GS+ +++ PT + P ++ P DG ++ V +D
Sbjct: 1012 GF----HAVDVD-SGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYED 1066
Query: 214 LTVVLNEEGICTQKCALNWTDIPVAMEH 241
V +N G T+ L W ++P ++ +
Sbjct: 1067 EGVYVNTYGRITKDVVLQWGEMPTSVAY 1094
>gi|157671919 hypothetical protein LOC374864 isoform 1 [Homo
sapiens]
Length = 867
Score = 39.3 bits (90), Expect = 0.016
Identities = 32/118 (27%), Positives = 57/118 (48%), Gaps = 10/118 (8%)
Query: 747 KLELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRF 806
K EL E A +QA + + H LD+ + N ++ D++ +K +E ++
Sbjct: 249 KTELEEANAKIQADIDYMNEHGPLLDSKQ-------NQELQDLKNHYKKKMEVMDLHRKV 301
Query: 807 NQVLKNLLHA-EFLRVQEERILHQQVKCIITEEKVCMVCKKKIG--NSAFARYPNGVV 861
N+ L+ L A E R++ ++I + K I +EK K++I NS F Y + V+
Sbjct: 302 NEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVI 359
>gi|157671917 hypothetical protein LOC374864 isoform 2 [Homo
sapiens]
Length = 829
Score = 39.3 bits (90), Expect = 0.016
Identities = 32/118 (27%), Positives = 57/118 (48%), Gaps = 10/118 (8%)
Query: 747 KLELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRF 806
K EL E A +QA + + H LD+ + N ++ D++ +K +E ++
Sbjct: 249 KTELEEANAKIQADIDYMNEHGPLLDSKQ-------NQELQDLKNHYKKKMEVMDLHRKV 301
Query: 807 NQVLKNLLHA-EFLRVQEERILHQQVKCIITEEKVCMVCKKKIG--NSAFARYPNGVV 861
N+ L+ L A E R++ ++I + K I +EK K++I NS F Y + V+
Sbjct: 302 NEELEEALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVI 359
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 38.9 bits (89), Expect = 0.021
Identities = 36/168 (21%), Positives = 73/168 (43%), Gaps = 11/168 (6%)
Query: 125 MCVAVKKKLQLY-FWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKG 183
+CVA+K+++ Y ++ + H + VP + MA +CVGF+ + ++G+G
Sbjct: 1317 LCVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEG 1376
Query: 184 SIKELFPTGKQLEPLVA--PL-ADGKVAVGQDDLTVVLNEEGICT-------QKCALNWT 233
+ + + +A P+ A V + + + N GI T ++ L W
Sbjct: 1377 NPYSMLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWP 1436
Query: 234 DIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGS 281
P + + PY+ V+I +Q++ L++ R + + GS
Sbjct: 1437 ANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGS 1484
>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
sapiens]
Length = 1638
Score = 38.9 bits (89), Expect = 0.021
Identities = 36/168 (21%), Positives = 73/168 (43%), Gaps = 11/168 (6%)
Query: 125 MCVAVKKKLQLY-FWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVDGKG 183
+CVA+K+++ Y ++ + H + VP + MA +CVGF+ + ++G+G
Sbjct: 1236 LCVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEG 1295
Query: 184 SIKELFPTGKQLEPLVA--PL-ADGKVAVGQDDLTVVLNEEGICT-------QKCALNWT 233
+ + + +A P+ A V + + + N GI T ++ L W
Sbjct: 1296 NPYSMLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWP 1355
Query: 234 DIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGS 281
P + + PY+ V+I +Q++ L++ R + + GS
Sbjct: 1356 ANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGS 1403
>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
Length = 3062
Score = 35.0 bits (79), Expect = 0.30
Identities = 43/164 (26%), Positives = 66/164 (40%), Gaps = 26/164 (15%)
Query: 391 PVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIID 450
P L G E++HL+LI +T D D Q + S L++G K +L +
Sbjct: 2465 PDLIGKPAEESHLSLIASVT-----------DKDPQGNGSDLIKGRD---GKSDILIEDE 2510
Query: 451 TTLLKCYLHTNVALVAPLLRLENNHCHI---EESEHVLKKAHKYSELIILYEKKGLHEKA 507
T++ K YL LV L+ EN H + + + K + + + L++K
Sbjct: 2511 TSIQKMYLGEGEVLVEGLVEEENRHLKLLPGKNTRDSFKLINSQFPFPQITNNEELNQKG 2570
Query: 508 LQVLVDQSKKANSPLKGHERTVQYL---QHLGTENLHLIFSYSV 548
KKA LK +Q + + ENL IF SV
Sbjct: 2571 ------SLKKATVTLKDEPNNLQIIVSKSPVQFENLEEIFDTSV 2608
>gi|22027627 TNF receptor-associated factor 5 [Homo sapiens]
Length = 557
Score = 35.0 bits (79), Expect = 0.30
Identities = 46/223 (20%), Positives = 83/223 (37%), Gaps = 52/223 (23%)
Query: 306 QLLQDKQFELALQLAEMK---DDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLG 362
+L+ +K +L Q++++ + +S+ QQ IK L +K F + Q+F K G
Sbjct: 251 RLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKL-------EKEFKQFAQLFGKNG 303
Query: 363 TDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLND 422
+ L ++ +H+ +L + QL++ +N
Sbjct: 304 S----------------------------FLPNIQVFASHIDKSAWLEAQVHQLLQMVNQ 335
Query: 423 SDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESE 482
++ PLME T+K K LL+ D L TN + H +I +++
Sbjct: 336 QQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETN---------KHDTHINIHKAQ 386
Query: 483 HVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGH 525
K E L E + K + + D K + GH
Sbjct: 387 -----LSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGH 424
>gi|77404348 TNF receptor-associated factor 5 [Homo sapiens]
Length = 557
Score = 35.0 bits (79), Expect = 0.30
Identities = 46/223 (20%), Positives = 83/223 (37%), Gaps = 52/223 (23%)
Query: 306 QLLQDKQFELALQLAEMK---DDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLG 362
+L+ +K +L Q++++ + +S+ QQ IK L +K F + Q+F K G
Sbjct: 251 RLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKL-------EKEFKQFAQLFGKNG 303
Query: 363 TDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLND 422
+ L ++ +H+ +L + QL++ +N
Sbjct: 304 S----------------------------FLPNIQVFASHIDKSAWLEAQVHQLLQMVNQ 335
Query: 423 SDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESE 482
++ PLME T+K K LL+ D L TN + H +I +++
Sbjct: 336 QQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETN---------KHDTHINIHKAQ 386
Query: 483 HVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGH 525
K E L E + K + + D K + GH
Sbjct: 387 -----LSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGH 424
>gi|11321603 TNF receptor-associated factor 5 [Homo sapiens]
Length = 557
Score = 35.0 bits (79), Expect = 0.30
Identities = 46/223 (20%), Positives = 83/223 (37%), Gaps = 52/223 (23%)
Query: 306 QLLQDKQFELALQLAEMK---DDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAKLG 362
+L+ +K +L Q++++ + +S+ QQ IK L +K F + Q+F K G
Sbjct: 251 RLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKL-------EKEFKQFAQLFGKNG 303
Query: 363 TDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLND 422
+ L ++ +H+ +L + QL++ +N
Sbjct: 304 S----------------------------FLPNIQVFASHIDKSAWLEAQVHQLLQMVNQ 335
Query: 423 SDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESE 482
++ PLME T+K K LL+ D L TN + H +I +++
Sbjct: 336 QQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETN---------KHDTHINIHKAQ 386
Query: 483 HVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGH 525
K E L E + K + + D K + GH
Sbjct: 387 -----LSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGH 424
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a
[Homo sapiens]
Length = 1701
Score = 34.3 bits (77), Expect = 0.52
Identities = 30/109 (27%), Positives = 49/109 (44%), Gaps = 21/109 (19%)
Query: 593 LEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVP-----AGEEEGELG 647
+E+ I WE+ +FH L ++ C YL S G+ P P A +L
Sbjct: 673 IENQIQQWEQNLEKFHMDLFRMRC---------YLASLQGGELPNPKSLLAAASRPSKLA 723
Query: 648 EYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALF 696
R L L +SS++ L+C D L +R L L + G++++ +F
Sbjct: 724 LGR---LGILSVSSFH---ALVCSRD-DSALRKRTLSLTQRGRNKKGIF 765
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 32.0 bits (71), Expect = 2.6
Identities = 48/198 (24%), Positives = 79/198 (39%), Gaps = 15/198 (7%)
Query: 387 PNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLL 446
P+ + +E + I + R++++ KLN D+Q ++ PL GT T + L
Sbjct: 351 PSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVE---L 407
Query: 447 QIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEK 506
+ L K + + +L L NN +++ H L K EL + K
Sbjct: 408 NLATNQLTKIPEDVSGLVSLEVLILSNN--LLKKLPHGLGNLRKLRELDLEENKLESLPN 465
Query: 507 ALQVLVDQSK--KANSPLKGHERTVQY---LQHLGT-ENLHLIFSYSVWVLRDFPEDGLK 560
+ L D K N+ L R + + L HLG ENL + L + E
Sbjct: 466 EIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEE---- 521
Query: 561 IFTEDLPEVESLPRDRVL 578
++ D P + SLP + L
Sbjct: 522 LYLNDNPNLHSLPFELAL 539
>gi|224591408 SH2 domain containing 4B isoform 2 [Homo sapiens]
Length = 309
Score = 31.2 bits (69), Expect = 4.4
Identities = 30/95 (31%), Positives = 44/95 (46%), Gaps = 5/95 (5%)
Query: 746 IKLELLEPKANLQAALQVLELHHSK-LDTTKALNLLPANTQINDIRIFLEKVLEENAQKK 804
I EL+ +A LQA + EL K + TK AN + RI EK E +K
Sbjct: 46 ISEELIAERARLQAQREAEELWRQKEAEITKKFRDALANEKA---RILAEKWKVEMEDRK 102
Query: 805 RFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEK 839
+VL+ +H EF R +EE + + + EE+
Sbjct: 103 AA-KVLEERIHEEFKRKEEEERKRGEEQIRLQEEQ 136
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,007,802
Number of Sequences: 37866
Number of extensions: 1588123
Number of successful extensions: 3965
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 3907
Number of HSP's gapped (non-prelim): 51
length of query: 875
length of database: 18,247,518
effective HSP length: 111
effective length of query: 764
effective length of database: 14,044,392
effective search space: 10729915488
effective search space used: 10729915488
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.