Search of human proteins with 53832009

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|53832009 calcium channel, voltage-dependent, T type, alpha
1H subunit isoform a [Homo sapiens]
         (2353 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H...  4793   0.0  
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...  4772   0.0  
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i...  2345   0.0  
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i...  2342   0.0  
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i...  2342   0.0  
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i...  2332   0.0  
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i...  2329   0.0  
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i...  2329   0.0  
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i...  2319   0.0  
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i...  2306   0.0  
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i...  2263   0.0  
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i...  2261   0.0  
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i...  2260   0.0  
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i...  2248   0.0  
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i...  2247   0.0  
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i...  2244   0.0  
gi|38505294 voltage-dependent calcium channel alpha 1G subunit i...  1612   0.0  
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I...  1599   0.0  
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I...  1595   0.0  
gi|37622907 voltage-gated sodium channel type V alpha isoform a ...   446   e-124
gi|150417967 voltage-gated sodium channel type V alpha isoform c...   446   e-124
gi|30089970 voltage-gated sodium channel type V alpha isoform b ...   446   e-124
gi|237512982 voltage-gated sodium channel type V alpha isoform f...   444   e-124
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi...   437   e-122
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ...   419   e-116
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo...   349   2e-95
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s...   337   6e-92
gi|126362955 sodium channel, voltage-gated, type III, alpha isof...   333   9e-91
gi|126362947 sodium channel, voltage-gated, type III, alpha isof...   333   9e-91
gi|126362949 sodium channel, voltage-gated, type III, alpha isof...   333   9e-91

>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform a [Homo sapiens]
          Length = 2353

 Score = 4793 bits (12432), Expect = 0.0
 Identities = 2353/2353 (100%), Positives = 2353/2353 (100%)

Query: 1    MTEGARAADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGA 60
            MTEGARAADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGA
Sbjct: 1    MTEGARAADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGA 60

Query: 61   ELGADEEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMF 120
            ELGADEEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMF
Sbjct: 61   ELGADEEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMF 120

Query: 121  RPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVV 180
            RPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVV
Sbjct: 121  RPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVV 180

Query: 181  AGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 240
            AGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV
Sbjct: 181  AGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 240

Query: 241  FFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQ 300
            FFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQ
Sbjct: 241  FFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQ 300

Query: 301  KCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAIN 360
            KCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAIN
Sbjct: 301  KCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAIN 360

Query: 361  FDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 420
            FDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT
Sbjct: 361  FDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 420

Query: 421  QFSETKQRESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYA 480
            QFSETKQRESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYA
Sbjct: 421  QFSETKQRESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYA 480

Query: 481  RWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPG 540
            RWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPG
Sbjct: 481  RWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPG 540

Query: 541  PEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAA 600
            PEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAA
Sbjct: 541  PEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAA 600

Query: 601  SLRLATGLGTMNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKI 660
            SLRLATGLGTMNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKI
Sbjct: 601  SLRLATGLGTMNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKI 660

Query: 661  PHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESG 720
            PHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESG
Sbjct: 661  PHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESG 720

Query: 721  DSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWV 780
            DSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWV
Sbjct: 721  DSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWV 780

Query: 781  TFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEM 840
            TFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEM
Sbjct: 781  TFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEM 840

Query: 841  LLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPA 900
            LLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPA
Sbjct: 841  LLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPA 900

Query: 901  LRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSL 960
            LRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSL
Sbjct: 901  LRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSL 960

Query: 961  LWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQA 1020
            LWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQA
Sbjct: 961  LWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQA 1020

Query: 1021 EGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCT 1080
            EGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCT
Sbjct: 1021 EGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCT 1080

Query: 1081 AATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSS 1140
            AATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSS
Sbjct: 1081 AATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSS 1140

Query: 1141 RRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLD 1200
            RRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLD
Sbjct: 1141 RRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLD 1200

Query: 1201 PRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEP 1260
            PRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEP
Sbjct: 1201 PRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEP 1260

Query: 1261 YKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDP 1320
            YKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDP
Sbjct: 1261 YKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDP 1320

Query: 1321 GSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIV 1380
            GSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIV
Sbjct: 1321 GSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIV 1380

Query: 1381 VAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAF 1440
            VAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAF
Sbjct: 1381 VAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAF 1440

Query: 1441 FIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVL 1500
            FIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVL
Sbjct: 1441 FIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVL 1500

Query: 1501 SSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHK 1560
            SSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHK
Sbjct: 1501 SSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHK 1560

Query: 1561 CRQHQEAEEARRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLD 1620
            CRQHQEAEEARRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLD
Sbjct: 1561 CRQHQEAEEARRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLD 1620

Query: 1621 LFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDR 1680
            LFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDR
Sbjct: 1621 LFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDR 1680

Query: 1681 WNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLD 1740
            WNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLD
Sbjct: 1681 WNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLD 1740

Query: 1741 TVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLT 1800
            TVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLT
Sbjct: 1741 TVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLT 1800

Query: 1801 LFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLM 1860
            LFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLM
Sbjct: 1801 LFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLM 1860

Query: 1861 KHLEESNKEAREDAELDAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVS 1920
            KHLEESNKEAREDAELDAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVS
Sbjct: 1861 KHLEESNKEAREDAELDAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVS 1920

Query: 1921 VSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLGSVASVHSPPAESCASLQ 1980
            VSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLGSVASVHSPPAESCASLQ
Sbjct: 1921 VSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLGSVASVHSPPAESCASLQ 1980

Query: 1981 IPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEP 2040
            IPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEP
Sbjct: 1981 IPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEP 2040

Query: 2041 GEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEE 2100
            GEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEE
Sbjct: 2041 GEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEE 2100

Query: 2101 VSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAEL 2160
            VSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAEL
Sbjct: 2101 VSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAEL 2160

Query: 2161 GSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRT 2220
            GSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRT
Sbjct: 2161 GSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRT 2220

Query: 2221 PSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDP 2280
            PSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDP
Sbjct: 2221 PSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDP 2280

Query: 2281 FLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEKRRGLYLTVPQCPLEKPGSPS 2340
            FLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEKRRGLYLTVPQCPLEKPGSPS
Sbjct: 2281 FLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEKRRGLYLTVPQCPLEKPGSPS 2340

Query: 2341 ATPAPGGGADDPV 2353
            ATPAPGGGADDPV
Sbjct: 2341 ATPAPGGGADDPV 2353


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score = 4772 bits (12378), Expect = 0.0
 Identities = 2346/2353 (99%), Positives = 2347/2353 (99%), Gaps = 6/2353 (0%)

Query: 1    MTEGARAADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGA 60
            MTEGARAADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGA
Sbjct: 1    MTEGARAADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGA 60

Query: 61   ELGADEEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMF 120
            ELGADEEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMF
Sbjct: 61   ELGADEEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMF 120

Query: 121  RPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVV 180
            RPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVV
Sbjct: 121  RPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVV 180

Query: 181  AGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 240
            AGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV
Sbjct: 181  AGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 240

Query: 241  FFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQ 300
            FFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQ
Sbjct: 241  FFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQ 300

Query: 301  KCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAIN 360
            KCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAIN
Sbjct: 301  KCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAIN 360

Query: 361  FDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 420
            FDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT
Sbjct: 361  FDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 420

Query: 421  QFSETKQRESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYA 480
            QFSETKQRESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYA
Sbjct: 421  QFSETKQRESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYA 480

Query: 481  RWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPG 540
            RWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPG
Sbjct: 481  RWQSRWRKKVDPSAVQGQGPGHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPG 540

Query: 541  PEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAA 600
            PEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAA
Sbjct: 541  PEPGACDTRLVRAGAPPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAA 600

Query: 601  SLRLATGLGTMNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKI 660
            SLRLATGLGTMNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKI
Sbjct: 601  SLRLATGLGTMNYPTILPSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKI 660

Query: 661  PHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESG 720
            PHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESG
Sbjct: 661  PHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESG 720

Query: 721  DSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWV 780
            DSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWV
Sbjct: 721  DSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWV 780

Query: 781  TFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEM 840
            TFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEM
Sbjct: 781  TFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEM 840

Query: 841  LLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPA 900
            LLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPA
Sbjct: 841  LLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPA 900

Query: 901  LRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSL 960
            LRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSL
Sbjct: 901  LRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSL 960

Query: 961  LWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQA 1020
            LWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQA
Sbjct: 961  LWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQA 1020

Query: 1021 EGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCT 1080
            EGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCT
Sbjct: 1021 EGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCT 1080

Query: 1081 AATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSS 1140
            AATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSS
Sbjct: 1081 AATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSS 1140

Query: 1141 RRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLD 1200
            RRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLD
Sbjct: 1141 RRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLD 1200

Query: 1201 PRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEP 1260
            PRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEP
Sbjct: 1201 PRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEP 1260

Query: 1261 YKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDP 1320
            YKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDP
Sbjct: 1261 YKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDP 1320

Query: 1321 GSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIV 1380
            GSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIV
Sbjct: 1321 GSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIV 1380

Query: 1381 VAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAF 1440
            VAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAF
Sbjct: 1381 VAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAF 1440

Query: 1441 FIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVL 1500
            FIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVL
Sbjct: 1441 FIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVL 1500

Query: 1501 SSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHK 1560
            SSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHK
Sbjct: 1501 SSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHK 1560

Query: 1561 CRQHQEAEEARRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLD 1620
            CRQHQEAEEARRREEKRLRRLERRRR      +AQRRPYYADYSPTRRSIHSLCTSHYLD
Sbjct: 1561 CRQHQEAEEARRREEKRLRRLERRRR------KAQRRPYYADYSPTRRSIHSLCTSHYLD 1614

Query: 1621 LFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDR 1680
            LFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDR
Sbjct: 1615 LFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDR 1674

Query: 1681 WNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLD 1740
            WNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLD
Sbjct: 1675 WNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLD 1734

Query: 1741 TVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLT 1800
            TVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLT
Sbjct: 1735 TVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLT 1794

Query: 1801 LFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLM 1860
            LFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLM
Sbjct: 1795 LFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLM 1854

Query: 1861 KHLEESNKEAREDAELDAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVS 1920
            KHLEESNKEAREDAELDAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVS
Sbjct: 1855 KHLEESNKEAREDAELDAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVS 1914

Query: 1921 VSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLGSVASVHSPPAESCASLQ 1980
            VSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLGSVASVHSPPAESCASLQ
Sbjct: 1915 VSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLGSVASVHSPPAESCASLQ 1974

Query: 1981 IPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEP 2040
            IPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEP
Sbjct: 1975 IPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEP 2034

Query: 2041 GEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEE 2100
            GEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEE
Sbjct: 2035 GEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEE 2094

Query: 2101 VSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAEL 2160
            VSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAEL
Sbjct: 2095 VSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAEL 2154

Query: 2161 GSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRT 2220
            GSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRT
Sbjct: 2155 GSGEPGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRT 2214

Query: 2221 PSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDP 2280
            PSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDP
Sbjct: 2215 PSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDP 2274

Query: 2281 FLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEKRRGLYLTVPQCPLEKPGSPS 2340
            FLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEKRRGLYLTVPQCPLEKPGSPS
Sbjct: 2275 FLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPEKRRGLYLTVPQCPLEKPGSPS 2334

Query: 2341 ATPAPGGGADDPV 2353
            ATPAPGGGADDPV
Sbjct: 2335 ATPAPGGGADDPV 2347


>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
            isoform 12 [Homo sapiens]
          Length = 2250

 Score = 2345 bits (6077), Expect = 0.0
 Identities = 1347/2347 (57%), Positives = 1563/2347 (66%), Gaps = 205/2347 (8%)

Query: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66

Query: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186

Query: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246

Query: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305

Query: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418

Query: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478

Query: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536

Query: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592

Query: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642

Query: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696

Query: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740

Query: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800

Query: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860

Query: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919

Query: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTD 1030
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S+++
Sbjct: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979

Query: 1031 EDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKS 1090
             D  S   + D  +         K C   V+   H E R SL PPLI+ TAATPM  PKS
Sbjct: 980  PDFFSPSLDGDGDR---------KKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKS 1030

Query: 1091 SPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSL 1148
            +         P SRR SSS    P    + K P S RSSP +PW  + +W+SRRSS +SL
Sbjct: 1031 TSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSL 1090

Query: 1149 GRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAA 1208
            GRAPSLKRR   GER SLLSGEG+ S D+E         P  +  R   SL+        
Sbjct: 1091 GRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFD 1150

Query: 1209 LPPT-----------------KCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCC 1251
            LP T                 + +D +G+  +      LR D    D  + DD+   S  
Sbjct: 1151 LPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKG 1210

Query: 1252 LRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTI 1311
             R+   +    P  C  R++W+ Y+F PQ+RFR+ C ++ITHKMFDHVVLV IFLNC+TI
Sbjct: 1211 ERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITI 1270

Query: 1312 ALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLL 1371
            A+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVVALG   GE AYL+SSWN+LDGLL
Sbjct: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330

Query: 1372 VLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIG 1431
            VL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL+SSL+PIG
Sbjct: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390

Query: 1432 NIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLG 1491
            NIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+ K+ C  A YRWVR KYNFDNLG
Sbjct: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLG 1450

Query: 1492 QALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFV 1551
            QALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHNPWMLLYFISFLLIV+FFVLNMFV
Sbjct: 1451 QALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFV 1510

Query: 1552 GVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPS-PEAQRRPYYADYSPTRRSI 1610
            GVVVENFHKCRQHQE EEARRREEKRLRRLE++RRS      EAQ +PYY+DYS  R  +
Sbjct: 1511 GVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLV 1570

Query: 1611 HSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVA 1670
            H LCTSHYLDLFIT +I +NV+TM+MEHY QP+ LDEALK CNY+FT++FV E+  KLVA
Sbjct: 1571 HHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVA 1630

Query: 1671 FGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLK 1730
            FGFRRFF+DRWNQLDLAIVLLS+MGITLEEIE++A+LPINPTIIRIMRVLRIARVLKLLK
Sbjct: 1631 FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLK 1690

Query: 1731 MATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHAT 1790
            MA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG LEC E +PCEGL RHAT
Sbjct: 1691 MAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHAT 1750

Query: 1791 FSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFV 1850
            F NFGMAFLTLFRVSTGDNWNGIMKDTLR+C   D+    Y   +SP+YFV+FVL AQFV
Sbjct: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC---DQESTCYNTVISPIYFVSFVLTAQFV 1807

Query: 1851 LVNVVVAVLMKHLEESNKEAREDAELDAEIELEM-------------------AQGPG-- 1889
            LVNVV+AVLMKHLEESNKEA+E+AEL+AE+ELEM                    +GP   
Sbjct: 1808 LVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSP 1867

Query: 1890 ---------------SARRVDADRP---PLPQESPGARDAPNLV-ARKVSVSRMLSLPND 1930
                           SA     + P   P P E PG    P+L+  RK  VSR  SLPND
Sbjct: 1868 DSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPG----PDLLTVRKSGVSRTHSLPND 1923

Query: 1931 SYMFRPVVPASAPHPRPLQEVEMETYGAGTP---LGSVASVHSPPAESCASLQIP----- 1982
            SYM R    A  P         +   G G P    GSV SVHS PA++   LQ+P     
Sbjct: 1924 SYMCRHGSTAEGP---------LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH 1974

Query: 1983 LAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGE 2042
            L     A +   +  L P G  RSP   R L RQ A+ TDSL+ +    R+ L     G 
Sbjct: 1975 LLQPHSAPTWGTIPKLPPPG--RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSG- 2031

Query: 2043 KTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGE--------EAEAS 2094
              P  P+ +  S     +S   A   +R H+   + ++     PG E        E  +S
Sbjct: 2032 --PSPPLARAYSFWG--QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSS 2087

Query: 2095 DPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKP-GRADEQ 2153
               D E+S I+    P      P G E  P     RDL++ YSV+AQ    +P    DEQ
Sbjct: 2088 LELDTELSWISGDLLP------PGGQEEPP---SPRDLKKCYSVEAQSCQRRPTSWLDEQ 2138

Query: 2154 WRPSAELGSGEPGEAKAWGPE-----AEP--ALGARRKKKMSPPCISVEPPAEDEGSARP 2206
             R S  +   + G     G +      +P    G+R KKK+SPP I+++PP E +G   P
Sbjct: 2139 RRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPP-ESQGPRTP 2197

Query: 2207 SAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSF 2266
             +       LRRR PS       DS +P     A G P +        S + + L++   
Sbjct: 2198 PSP---GICLRRRAPS------SDSKDPL----ASGPPDSMA---ASPSPKKDVLSLSGL 2241

Query: 2267 AFEPLDL 2273
            + +P DL
Sbjct: 2242 SSDPADL 2248


>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
            isoform 13 [Homo sapiens]
          Length = 2243

 Score = 2342 bits (6070), Expect = 0.0
 Identities = 1345/2346 (57%), Positives = 1562/2346 (66%), Gaps = 210/2346 (8%)

Query: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66

Query: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186

Query: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246

Query: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305

Query: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418

Query: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478

Query: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536

Query: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592

Query: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642

Query: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696

Query: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740

Query: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800

Query: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860

Query: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919

Query: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTD 1030
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S+++
Sbjct: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979

Query: 1031 EDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKS 1090
             D  S   + D  +         K C   V+   H E R SL PPLI+ TAATPM  PKS
Sbjct: 980  PDFFSPSLDGDGDR---------KKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKS 1030

Query: 1091 SPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSL 1148
            +         P SRR SSS    P    + K P S RSSP +PW  + +W+SRRSS +SL
Sbjct: 1031 TSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSL 1090

Query: 1149 GRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAA 1208
            GRAPSLKRR   GER SLLSGEG+ S D+E         P  +  R   SL+        
Sbjct: 1091 GRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFD 1150

Query: 1209 LPPT-----------------KCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCC 1251
            LP T                 + +D +G+  +      LR D    D  + DD+   S  
Sbjct: 1151 LPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKG 1210

Query: 1252 LRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTI 1311
             R+   +    P  C  R++W+ Y+F PQ+RFR+ C ++ITHKMFDHVVLV IFLNC+TI
Sbjct: 1211 ERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITI 1270

Query: 1312 ALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLL 1371
            A+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVVALG   GE AYL+SSWN+LDGLL
Sbjct: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330

Query: 1372 VLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIG 1431
            VL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL+SSL+PIG
Sbjct: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390

Query: 1432 NIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLG 1491
            NIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+ K+ C  A YRWVR KYNFDNLG
Sbjct: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLG 1450

Query: 1492 QALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFV 1551
            QALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHNPWMLLYFISFLLIV+FFVLNMFV
Sbjct: 1451 QALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFV 1510

Query: 1552 GVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIH 1611
            GVVVENFHKCRQHQE EEARRREEKRLRRLE++RR      +AQ +PYY+DYS  R  +H
Sbjct: 1511 GVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR------KAQCKPYYSDYSRFRLLVH 1564

Query: 1612 SLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAF 1671
             LCTSHYLDLFIT +I +NV+TM+MEHY QP+ LDEALK CNY+FT++FV E+  KLVAF
Sbjct: 1565 HLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAF 1624

Query: 1672 GFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKM 1731
            GFRRFF+DRWNQLDLAIVLLS+MGITLEEIE++A+LPINPTIIRIMRVLRIARVLKLLKM
Sbjct: 1625 GFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKM 1684

Query: 1732 ATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATF 1791
            A GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG LEC E +PCEGL RHATF
Sbjct: 1685 AVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATF 1744

Query: 1792 SNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVL 1851
             NFGMAFLTLFRVSTGDNWNGIMKDTLR+C   D+    Y   +SP+YFV+FVL AQFVL
Sbjct: 1745 RNFGMAFLTLFRVSTGDNWNGIMKDTLRDC---DQESTCYNTVISPIYFVSFVLTAQFVL 1801

Query: 1852 VNVVVAVLMKHLEESNKEAREDAELDAEIELEM-------------------AQGPG--- 1889
            VNVV+AVLMKHLEESNKEA+E+AEL+AE+ELEM                    +GP    
Sbjct: 1802 VNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPD 1861

Query: 1890 --------------SARRVDADRP---PLPQESPGARDAPNLV-ARKVSVSRMLSLPNDS 1931
                          SA     + P   P P E PG    P+L+  RK  VSR  SLPNDS
Sbjct: 1862 SPKPGALHPAAHARSASHFSLEHPTMQPHPTELPG----PDLLTVRKSGVSRTHSLPNDS 1917

Query: 1932 YMFRPVVPASAPHPRPLQEVEMETYGAGTP---LGSVASVHSPPAESCASLQIP-----L 1983
            YM R    A  P         +   G G P    GSV SVHS PA++   LQ+P     L
Sbjct: 1918 YMCRHGSTAEGP---------LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHL 1968

Query: 1984 AVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEK 2043
                 A +   +  L P G  RSP   R L RQ A+ TDSL+ +    R+ L     G  
Sbjct: 1969 LQPHSAPTWGTIPKLPPPG--RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSG-- 2024

Query: 2044 TPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGE--------EAEASD 2095
             P  P+ +  S     +S   A   +R H+   + ++     PG E        E  +S 
Sbjct: 2025 -PSPPLARAYSFWG--QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSL 2081

Query: 2096 PADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKP-GRADEQW 2154
              D E+S I+    P      P G E  P     RDL++ YSV+AQ    +P    DEQ 
Sbjct: 2082 ELDTELSWISGDLLP------PGGQEEPP---SPRDLKKCYSVEAQSCQRRPTSWLDEQR 2132

Query: 2155 RPSAELGSGEPGEAKAWGPE-----AEP--ALGARRKKKMSPPCISVEPPAEDEGSARPS 2207
            R S  +   + G     G +      +P    G+R KKK+SPP I+++PP E +G   P 
Sbjct: 2133 RHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPP-ESQGPRTPP 2191

Query: 2208 AAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFA 2267
            +       LRRR PS       DS +P     A G P +        S + + L++   +
Sbjct: 2192 SP---GICLRRRAPS------SDSKDPL----ASGPPDSMA---ASPSPKKDVLSLSGLS 2235

Query: 2268 FEPLDL 2273
             +P DL
Sbjct: 2236 SDPADL 2241


>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
            isoform 11 [Homo sapiens]
          Length = 2261

 Score = 2342 bits (6069), Expect = 0.0
 Identities = 1347/2358 (57%), Positives = 1564/2358 (66%), Gaps = 216/2358 (9%)

Query: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66

Query: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186

Query: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246

Query: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305

Query: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418

Query: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478

Query: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536

Query: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592

Query: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642

Query: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696

Query: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740

Query: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800

Query: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860

Query: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919

Query: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTD 1030
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S+++
Sbjct: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979

Query: 1031 EDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKS 1090
             D  S   + D  +         K C   V+   H E R SL PPLI+ TAATPM  PKS
Sbjct: 980  PDFFSPSLDGDGDR---------KKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKS 1030

Query: 1091 SPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSL 1148
            +         P SRR SSS    P    + K P S RSSP +PW  + +W+SRRSS +SL
Sbjct: 1031 TSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSL 1090

Query: 1149 GRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAA 1208
            GRAPSLKRR   GER SLLSGEG+ S D+E         P  +  R   SL+        
Sbjct: 1091 GRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFD 1150

Query: 1209 LPPT-----------------KCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCC 1251
            LP T                 + +D +G+  +      LR D    D  + DD+   S  
Sbjct: 1151 LPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKG 1210

Query: 1252 LRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTI 1311
             R+   +    P  C  R++W+ Y+F PQ+RFR+ C ++ITHKMFDHVVLV IFLNC+TI
Sbjct: 1211 ERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITI 1270

Query: 1312 ALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLL 1371
            A+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVVALG   GE AYL+SSWN+LDGLL
Sbjct: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330

Query: 1372 VLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIG 1431
            VL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL+SSL+PIG
Sbjct: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390

Query: 1432 NIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLG 1491
            NIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+ K+ C  A YRWVR KYNFDNLG
Sbjct: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLG 1450

Query: 1492 QALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFV 1551
            QALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHNPWMLLYFISFLLIV+FFVLNMFV
Sbjct: 1451 QALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFV 1510

Query: 1552 GVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR------------STFPSPEAQRRPY 1599
            GVVVENFHKCRQHQE EEARRREEKRLRRLE++RR            S   + EAQ +PY
Sbjct: 1511 GVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPY 1570

Query: 1600 YADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIV 1659
            Y+DYS  R  +H LCTSHYLDLFIT +I +NV+TM+MEHY QP+ LDEALK CNY+FT++
Sbjct: 1571 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1630

Query: 1660 FVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRV 1719
            FV E+  KLVAFGFRRFF+DRWNQLDLAIVLLS+MGITLEEIE++A+LPINPTIIRIMRV
Sbjct: 1631 FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV 1690

Query: 1720 LRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSED 1779
            LRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG LEC E 
Sbjct: 1691 LRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDET 1750

Query: 1780 NPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVY 1839
            +PCEGL RHATF NFGMAFLTLFRVSTGDNWNGIMKDTLR+C   D+    Y   +SP+Y
Sbjct: 1751 HPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC---DQESTCYNTVISPIY 1807

Query: 1840 FVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEM--------------- 1884
            FV+FVL AQFVLVNVV+AVLMKHLEESNKEA+E+AEL+AE+ELEM               
Sbjct: 1808 FVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPF 1867

Query: 1885 ----AQGPG-----------------SARRVDADRP---PLPQESPGARDAPNLV-ARKV 1919
                 +GP                  SA     + P   P P E PG    P+L+  RK 
Sbjct: 1868 LWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPG----PDLLTVRKS 1923

Query: 1920 SVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTP---LGSVASVHSPPAESC 1976
             VSR  SLPNDSYM R    A  P         +   G G P    GSV SVHS PA++ 
Sbjct: 1924 GVSRTHSLPNDSYMCRHGSTAEGP---------LGHRGWGLPKAQSGSVLSVHSQPADTS 1974

Query: 1977 ASLQIP-----LAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSP 2031
              LQ+P     L     A +   +  L P G  RSP   R L RQ A+ TDSL+ +    
Sbjct: 1975 YILQLPKDAPHLLQPHSAPTWGTIPKLPPPG--RSPLAQRPLRRQAAIRTDSLDVQGLGS 2032

Query: 2032 RDTLDPAEPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGE-- 2089
            R+ L     G   P  P+ +  S     +S   A   +R H+   + ++     PG E  
Sbjct: 2033 REDLLAEVSG---PSPPLARAYSFWG--QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPN 2087

Query: 2090 ------EAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGF 2143
                  E  +S   D E+S I+    P      P G E  P     RDL++ YSV+AQ  
Sbjct: 2088 WGKGPPETRSSLELDTELSWISGDLLP------PGGQEEPP---SPRDLKKCYSVEAQSC 2138

Query: 2144 LDKP-GRADEQWRPSAELGSGEPGEAKAWGPE-----AEP--ALGARRKKKMSPPCISVE 2195
              +P    DEQ R S  +   + G     G +      +P    G+R KKK+SPP I+++
Sbjct: 2139 QRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITID 2198

Query: 2196 PPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQAS 2255
            PP E +G   P +       LRRR PS       DS +P     A G P +        S
Sbjct: 2199 PP-ESQGPRTPPSP---GICLRRRAPS------SDSKDPL----ASGPPDSMA---ASPS 2241

Query: 2256 CRAEHLTVPSFAFEPLDL 2273
             + + L++   + +P DL
Sbjct: 2242 PKKDVLSLSGLSSDPADL 2259


>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
            isoform 9 [Homo sapiens]
          Length = 2273

 Score = 2332 bits (6043), Expect = 0.0
 Identities = 1347/2370 (56%), Positives = 1563/2370 (65%), Gaps = 228/2370 (9%)

Query: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66

Query: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186

Query: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246

Query: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305

Query: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418

Query: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478

Query: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536

Query: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592

Query: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642

Query: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696

Query: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740

Query: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800

Query: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860

Query: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919

Query: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE--------- 1021
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAE         
Sbjct: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979

Query: 1022 --------------GDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLE 1067
                          GDAN+S+++ D  S   + D  +         K C   V+   H E
Sbjct: 980  GQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDR---------KKCLALVSLGEHPE 1030

Query: 1068 GRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLR 1125
             R SL PPLI+ TAATPM  PKS+         P SRR SSS    P    + K P S R
Sbjct: 1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR 1090

Query: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAA 1185
            SSP +PW  + +W+SRRSS +SLGRAPSLKRR   GER SLLSGEG+ S D+E       
Sbjct: 1091 SSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEER 1150

Query: 1186 PGPRATPLRRAESLDPRPLRPAALPPT-----------------KCRDRDGQVVALPSDF 1228
              P  +  R   SL+        LP T                 + +D +G+  +     
Sbjct: 1151 ASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLAR 1210

Query: 1229 FLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQ 1288
             LR D    D  + DD+   S   R+   +    P  C  R++W+ Y+F PQ+RFR+ C 
Sbjct: 1211 ALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCH 1270

Query: 1289 KVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVV 1348
            ++ITHKMFDHVVLV IFLNC+TIA+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVV
Sbjct: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330

Query: 1349 ALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLR 1408
            ALG   GE AYL+SSWN+LDGLLVL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLR
Sbjct: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390

Query: 1409 VISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468
            VISRA GLKLVVETL+SSL+PIGNIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+
Sbjct: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450

Query: 1469 TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHN 1528
             K+ C  A YRWVR KYNFDNLGQALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHN
Sbjct: 1451 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1510

Query: 1529 PWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRST 1588
            PWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLE++RRS 
Sbjct: 1511 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSK 1570

Query: 1589 FPS-PEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDE 1647
                 EAQ +PYY+DYS  R  +H LCTSHYLDLFIT +I +NV+TM+MEHY QP+ LDE
Sbjct: 1571 EKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDE 1630

Query: 1648 ALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAAL 1707
            ALK CNY+FT++FV E+  KLVAFGFRRFF+DRWNQLDLAIVLLS+MGITLEEIE++A+L
Sbjct: 1631 ALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASL 1690

Query: 1708 PINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALG 1767
            PINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALG
Sbjct: 1691 PINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALG 1750

Query: 1768 VELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKH 1827
            VELFG LEC E +PCEGL RHATF NFGMAFLTLFRVSTGDNWNGIMKDTLR+C   D+ 
Sbjct: 1751 VELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC---DQE 1807

Query: 1828 CLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEM--- 1884
               Y   +SP+YFV+FVL AQFVLVNVV+AVLMKHLEESNKEA+E+AEL+AE+ELEM   
Sbjct: 1808 STCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1867

Query: 1885 ----------------AQGPG-----------------SARRVDADRP---PLPQESPGA 1908
                             +GP                  SA     + P   P P E PG 
Sbjct: 1868 SPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPG- 1926

Query: 1909 RDAPNLV-ARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTP---LGS 1964
               P+L+  RK  VSR  SLPNDSYM R    A  P         +   G G P    GS
Sbjct: 1927 ---PDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGP---------LGHRGWGLPKAQSGS 1974

Query: 1965 VASVHSPPAESCASLQIP-----LAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAV 2019
            V SVHS PA++   LQ+P     L     A +   +  L P G  RSP   R L RQ A+
Sbjct: 1975 VLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPG--RSPLAQRPLRRQAAI 2032

Query: 2020 HTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCV 2079
             TDSL+ +    R+ L     G   P  P+ +  S     +S   A   +R H+   + +
Sbjct: 2033 RTDSLDVQGLGSREDLLAEVSG---PSPPLARAYSFWG--QSSTQAQQHSRSHSKISKHM 2087

Query: 2080 SSRPAAPGGE--------EAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERD 2131
            +     PG E        E  +S   D E+S I+    P      P G E  P     RD
Sbjct: 2088 TPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLP------PGGQEEPP---SPRD 2138

Query: 2132 LRRLYSVDAQGFLDKP-GRADEQWRPSAELGSGEPGEAKAWGPE-----AEP--ALGARR 2183
            L++ YSV+AQ    +P    DEQ R S  +   + G     G +      +P    G+R 
Sbjct: 2139 LKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRP 2198

Query: 2184 KKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGD 2243
            KKK+SPP I+++PP E +G   P +       LRRR PS       DS +P     A G 
Sbjct: 2199 KKKLSPPSITIDPP-ESQGPRTPPSP---GICLRRRAPS------SDSKDPL----ASGP 2244

Query: 2244 PAAKGERWGQASCRAEHLTVPSFAFEPLDL 2273
            P +        S + + L++   + +P DL
Sbjct: 2245 PDSMA---ASPSPKKDVLSLSGLSSDPADL 2271


>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
            isoform 10 [Homo sapiens]
          Length = 2266

 Score = 2329 bits (6036), Expect = 0.0
 Identities = 1345/2369 (56%), Positives = 1562/2369 (65%), Gaps = 233/2369 (9%)

Query: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66

Query: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186

Query: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246

Query: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305

Query: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418

Query: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478

Query: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536

Query: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592

Query: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642

Query: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696

Query: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740

Query: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800

Query: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860

Query: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919

Query: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE--------- 1021
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAE         
Sbjct: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979

Query: 1022 --------------GDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLE 1067
                          GDAN+S+++ D  S   + D  +         K C   V+   H E
Sbjct: 980  GQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDR---------KKCLALVSLGEHPE 1030

Query: 1068 GRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLR 1125
             R SL PPLI+ TAATPM  PKS+         P SRR SSS    P    + K P S R
Sbjct: 1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR 1090

Query: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAA 1185
            SSP +PW  + +W+SRRSS +SLGRAPSLKRR   GER SLLSGEG+ S D+E       
Sbjct: 1091 SSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEER 1150

Query: 1186 PGPRATPLRRAESLDPRPLRPAALPPT-----------------KCRDRDGQVVALPSDF 1228
              P  +  R   SL+        LP T                 + +D +G+  +     
Sbjct: 1151 ASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLAR 1210

Query: 1229 FLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQ 1288
             LR D    D  + DD+   S   R+   +    P  C  R++W+ Y+F PQ+RFR+ C 
Sbjct: 1211 ALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCH 1270

Query: 1289 KVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVV 1348
            ++ITHKMFDHVVLV IFLNC+TIA+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVV
Sbjct: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330

Query: 1349 ALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLR 1408
            ALG   GE AYL+SSWN+LDGLLVL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLR
Sbjct: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390

Query: 1409 VISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468
            VISRA GLKLVVETL+SSL+PIGNIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+
Sbjct: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450

Query: 1469 TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHN 1528
             K+ C  A YRWVR KYNFDNLGQALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHN
Sbjct: 1451 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1510

Query: 1529 PWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRST 1588
            PWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLE++RR  
Sbjct: 1511 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRR-- 1568

Query: 1589 FPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEA 1648
                +AQ +PYY+DYS  R  +H LCTSHYLDLFIT +I +NV+TM+MEHY QP+ LDEA
Sbjct: 1569 ----KAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEA 1624

Query: 1649 LKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALP 1708
            LK CNY+FT++FV E+  KLVAFGFRRFF+DRWNQLDLAIVLLS+MGITLEEIE++A+LP
Sbjct: 1625 LKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLP 1684

Query: 1709 INPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGV 1768
            INPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGV
Sbjct: 1685 INPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGV 1744

Query: 1769 ELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHC 1828
            ELFG LEC E +PCEGL RHATF NFGMAFLTLFRVSTGDNWNGIMKDTLR+C   D+  
Sbjct: 1745 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC---DQES 1801

Query: 1829 LSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEM---- 1884
              Y   +SP+YFV+FVL AQFVLVNVV+AVLMKHLEESNKEA+E+AEL+AE+ELEM    
Sbjct: 1802 TCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLS 1861

Query: 1885 ---------------AQGPG-----------------SARRVDADRP---PLPQESPGAR 1909
                            +GP                  SA     + P   P P E PG  
Sbjct: 1862 PQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPG-- 1919

Query: 1910 DAPNLV-ARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTP---LGSV 1965
              P+L+  RK  VSR  SLPNDSYM R    A  P         +   G G P    GSV
Sbjct: 1920 --PDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGP---------LGHRGWGLPKAQSGSV 1968

Query: 1966 ASVHSPPAESCASLQIP-----LAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVH 2020
             SVHS PA++   LQ+P     L     A +   +  L P G  RSP   R L RQ A+ 
Sbjct: 1969 LSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPG--RSPLAQRPLRRQAAIR 2026

Query: 2021 TDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVS 2080
            TDSL+ +    R+ L     G   P  P+ +  S     +S   A   +R H+   + ++
Sbjct: 2027 TDSLDVQGLGSREDLLAEVSG---PSPPLARAYSFWG--QSSTQAQQHSRSHSKISKHMT 2081

Query: 2081 SRPAAPGGE--------EAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDL 2132
                 PG E        E  +S   D E+S I+    P      P G E  P     RDL
Sbjct: 2082 PPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLP------PGGQEEPP---SPRDL 2132

Query: 2133 RRLYSVDAQGFLDKP-GRADEQWRPSAELGSGEPGEAKAWGPE-----AEP--ALGARRK 2184
            ++ YSV+AQ    +P    DEQ R S  +   + G     G +      +P    G+R K
Sbjct: 2133 KKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPK 2192

Query: 2185 KKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGDP 2244
            KK+SPP I+++PP E +G   P +       LRRR PS       DS +P     A G P
Sbjct: 2193 KKLSPPSITIDPP-ESQGPRTPPSP---GICLRRRAPS------SDSKDPL----ASGPP 2238

Query: 2245 AAKGERWGQASCRAEHLTVPSFAFEPLDL 2273
             +        S + + L++   + +P DL
Sbjct: 2239 DSMA---ASPSPKKDVLSLSGLSSDPADL 2264


>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
            isoform 8 [Homo sapiens]
          Length = 2284

 Score = 2329 bits (6035), Expect = 0.0
 Identities = 1347/2381 (56%), Positives = 1564/2381 (65%), Gaps = 239/2381 (10%)

Query: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66

Query: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186

Query: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246

Query: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305

Query: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418

Query: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478

Query: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536

Query: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592

Query: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642

Query: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696

Query: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740

Query: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800

Query: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860

Query: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919

Query: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE--------- 1021
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAE         
Sbjct: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979

Query: 1022 --------------GDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLE 1067
                          GDAN+S+++ D  S   + D  +         K C   V+   H E
Sbjct: 980  GQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDR---------KKCLALVSLGEHPE 1030

Query: 1068 GRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLR 1125
             R SL PPLI+ TAATPM  PKS+         P SRR SSS    P    + K P S R
Sbjct: 1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR 1090

Query: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAA 1185
            SSP +PW  + +W+SRRSS +SLGRAPSLKRR   GER SLLSGEG+ S D+E       
Sbjct: 1091 SSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEER 1150

Query: 1186 PGPRATPLRRAESLDPRPLRPAALPPT-----------------KCRDRDGQVVALPSDF 1228
              P  +  R   SL+        LP T                 + +D +G+  +     
Sbjct: 1151 ASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLAR 1210

Query: 1229 FLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQ 1288
             LR D    D  + DD+   S   R+   +    P  C  R++W+ Y+F PQ+RFR+ C 
Sbjct: 1211 ALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCH 1270

Query: 1289 KVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVV 1348
            ++ITHKMFDHVVLV IFLNC+TIA+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVV
Sbjct: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330

Query: 1349 ALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLR 1408
            ALG   GE AYL+SSWN+LDGLLVL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLR
Sbjct: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390

Query: 1409 VISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468
            VISRA GLKLVVETL+SSL+PIGNIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+
Sbjct: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450

Query: 1469 TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHN 1528
             K+ C  A YRWVR KYNFDNLGQALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHN
Sbjct: 1451 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1510

Query: 1529 PWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR-- 1586
            PWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLE++RR  
Sbjct: 1511 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNL 1570

Query: 1587 ----------STFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSM 1636
                      S   + EAQ +PYY+DYS  R  +H LCTSHYLDLFIT +I +NV+TM+M
Sbjct: 1571 MLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1630

Query: 1637 EHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI 1696
            EHY QP+ LDEALK CNY+FT++FV E+  KLVAFGFRRFF+DRWNQLDLAIVLLS+MGI
Sbjct: 1631 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1690

Query: 1697 TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1756
            TLEEIE++A+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLF
Sbjct: 1691 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1750

Query: 1757 MLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKD 1816
            MLLFFI+AALGVELFG LEC E +PCEGL RHATF NFGMAFLTLFRVSTGDNWNGIMKD
Sbjct: 1751 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1810

Query: 1817 TLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAEL 1876
            TLR+C   D+    Y   +SP+YFV+FVL AQFVLVNVV+AVLMKHLEESNKEA+E+AEL
Sbjct: 1811 TLRDC---DQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1867

Query: 1877 DAEIELEM-------------------AQGPG-----------------SARRVDADRP- 1899
            +AE+ELEM                    +GP                  SA     + P 
Sbjct: 1868 EAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPT 1927

Query: 1900 --PLPQESPGARDAPNLV-ARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETY 1956
              P P E PG    P+L+  RK  VSR  SLPNDSYM R    A  P         +   
Sbjct: 1928 MQPHPTELPG----PDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGP---------LGHR 1974

Query: 1957 GAGTP---LGSVASVHSPPAESCASLQIP-----LAVSSPARSGEPLHALSPRGTARSPS 2008
            G G P    GSV SVHS PA++   LQ+P     L     A +   +  L P G  RSP 
Sbjct: 1975 GWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPG--RSPL 2032

Query: 2009 LSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQSPPRSPRPASVR 2068
              R L RQ A+ TDSL+ +    R+ L     G   P  P+ +  S     +S   A   
Sbjct: 2033 AQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSG---PSPPLARAYSFWG--QSSTQAQQH 2087

Query: 2069 TRKHTFGQRCVSSRPAAPGGE--------EAEASDPADEEVSHITSSACPWQPTAEPHGP 2120
            +R H+   + ++     PG E        E  +S   D E+S I+    P      P G 
Sbjct: 2088 SRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLP------PGGQ 2141

Query: 2121 EASPVAGGERDLRRLYSVDAQGFLDKP-GRADEQWRPSAELGSGEPGEAKAWGPE----- 2174
            E  P     RDL++ YSV+AQ    +P    DEQ R S  +   + G     G +     
Sbjct: 2142 EEPP---SPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLG 2198

Query: 2175 AEP--ALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSL 2232
             +P    G+R KKK+SPP I+++PP E +G   P +       LRRR PS       DS 
Sbjct: 2199 GQPLGGPGSRPKKKLSPPSITIDPP-ESQGPRTPPSP---GICLRRRAPS------SDSK 2248

Query: 2233 EPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDL 2273
            +P     A G P +        S + + L++   + +P DL
Sbjct: 2249 DPL----ASGPPDSMA---ASPSPKKDVLSLSGLSSDPADL 2282


>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
            isoform 6 [Homo sapiens]
          Length = 2306

 Score = 2319 bits (6009), Expect = 0.0
 Identities = 1338/2390 (55%), Positives = 1562/2390 (65%), Gaps = 235/2390 (9%)

Query: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66

Query: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186

Query: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246

Query: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305

Query: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418

Query: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478

Query: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536

Query: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592

Query: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642

Query: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696

Query: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740

Query: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800

Query: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860

Query: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919

Query: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTD 1030
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S+++
Sbjct: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979

Query: 1031 EDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKS 1090
             D  S   + D  +         K C   V+   H E R SL PPLI+ TAATPM  PKS
Sbjct: 980  PDFFSPSLDGDGDR---------KKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKS 1030

Query: 1091 SPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSL 1148
            +         P SRR SSS    P    + K P S RSSP +PW  + +W+SRRSS +SL
Sbjct: 1031 TSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSL 1090

Query: 1149 GRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAA 1208
            GRAPSLKRR   GER SLLSGEG+ S D+E         P  +  R   SL+        
Sbjct: 1091 GRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFD 1150

Query: 1209 LPPT-----------------KCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCC 1251
            LP T                 + +D +G+  +      LR D    D  + DD+   S  
Sbjct: 1151 LPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKG 1210

Query: 1252 LRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTI 1311
             R+   +    P  C  R++W+ Y+F PQ+RFR+ C ++ITHKMFDHVVLV IFLNC+TI
Sbjct: 1211 ERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITI 1270

Query: 1312 ALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLL 1371
            A+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVVALG   GE AYL+SSWN+LDGLL
Sbjct: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330

Query: 1372 VLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIG 1431
            VL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL+SSL+PIG
Sbjct: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390

Query: 1432 NIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLG 1491
            NIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+ K+ C  A YRWVR KYNFDNLG
Sbjct: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLG 1450

Query: 1492 QALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFV 1551
            QALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHNPWMLLYFISFLLIV+FFVLNMFV
Sbjct: 1451 QALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFV 1510

Query: 1552 GVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR------------STFPSPEAQRRPY 1599
            GVVVENFHKCRQHQE EEARRREEKRLRRLE++RR            S   + EAQ +PY
Sbjct: 1511 GVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPY 1570

Query: 1600 YADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIV 1659
            Y+DYS  R  +H LCTSHYLDLFIT +I +NV+TM+MEHY QP+ LDEALK CNY+FT++
Sbjct: 1571 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1630

Query: 1660 FVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRV 1719
            FV E+  KLVAFGFRRFF+DRWNQLDLAIVLLS+MGITLEEIE++A+LPINPTIIRIMRV
Sbjct: 1631 FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV 1690

Query: 1720 LRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSED 1779
            LRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG LEC E 
Sbjct: 1691 LRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDET 1750

Query: 1780 NPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVY 1839
            +PCEGL RHATF NFGMAFLTLFRVSTGDNWNGIMKDTLR+C   D+    Y   +SP+Y
Sbjct: 1751 HPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC---DQESTCYNTVISPIY 1807

Query: 1840 FVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEM--------------- 1884
            FV+FVL AQFVLVNVV+AVLMKHLEESNKEA+E+AEL+AE+ELEM               
Sbjct: 1808 FVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPF 1867

Query: 1885 ----AQGPG-----------------SARRVDADRPPLPQESPGARDAPNLVARKVSVSR 1923
                 +GP                  SA     + P +P     A    + +  + S S 
Sbjct: 1868 LWPGVEGPDSPDSPKPGALHPAAHARSASHFSLEHPTIPLAEMEALSLTSEIVSEPSCSL 1927

Query: 1924 ML---SLPNDSY--MFRPVVPASAPHPRPLQEVEMETY---------------------- 1956
             L   SLP+D +  +   +     PHP  L   ++ T                       
Sbjct: 1928 ALTDDSLPDDMHTLLLSALESNMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGS 1987

Query: 1957 ---------GAGTP---LGSVASVHSPPAESCASLQIP-----LAVSSPARSGEPLHALS 1999
                     G G P    GSV SVHS PA++   LQ+P     L     A +   +  L 
Sbjct: 1988 TAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLP 2047

Query: 2000 PRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQSPP 2059
            P G  RSP   R L RQ A+ TDSL+ +    R+ L     G   P  P+ +  S     
Sbjct: 2048 PPG--RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSG---PSPPLARAYSFWG-- 2100

Query: 2060 RSPRPASVRTRKHTFGQRCVSSRPAAPGGE--------EAEASDPADEEVSHITSSACPW 2111
            +S   A   +R H+   + ++     PG E        E  +S   D E+S I+    P 
Sbjct: 2101 QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLP- 2159

Query: 2112 QPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKP-GRADEQWRPSAELGSGEPGEAKA 2170
                 P G E  P     RDL++ YSV+AQ    +P    DEQ R S  +   + G    
Sbjct: 2160 -----PGGQEEPP---SPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPH 2211

Query: 2171 WGPE-----AEP--ALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSC 2223
             G +      +P    G+R KKK+SPP I+++PP E +G   P +       LRRR PS 
Sbjct: 2212 LGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPP-ESQGPRTPPSP---GICLRRRAPS- 2266

Query: 2224 EATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDL 2273
                  DS +P     A G P +        S + + L++   + +P DL
Sbjct: 2267 -----SDSKDPL----ASGPPDSMA---ASPSPKKDVLSLSGLSSDPADL 2304


>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
            isoform 14 [Homo sapiens]
          Length = 2171

 Score = 2306 bits (5975), Expect = 0.0
 Identities = 1291/2157 (59%), Positives = 1482/2157 (68%), Gaps = 165/2157 (7%)

Query: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66

Query: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186

Query: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246

Query: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305

Query: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418

Query: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478

Query: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536

Query: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592

Query: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642

Query: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696

Query: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740

Query: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800

Query: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860

Query: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919

Query: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTD 1030
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S+++
Sbjct: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979

Query: 1031 EDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKS 1090
             D  S   + D  +         K C   V+   H E R SL PPLI+ TAATPM  PKS
Sbjct: 980  PDFFSPSLDGDGDR---------KKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKS 1030

Query: 1091 SPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSL 1148
            +         P SRR SSS    P    + K P S RSSP +PW  + +W+SRRSS +SL
Sbjct: 1031 TSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSL 1090

Query: 1149 GRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAA 1208
            GRAPSLKRR   GER SLLSGEG+ S D+E         P  +  R   SL+        
Sbjct: 1091 GRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFD 1150

Query: 1209 LPPT-----------------KCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCC 1251
            LP T                 + +D +G+  +      LR D    D  + DD+   S  
Sbjct: 1151 LPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKG 1210

Query: 1252 LRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTI 1311
             R+   +    P  C  R++W+ Y+F PQ+RFR+ C ++ITHKMFDHVVLV IFLNC+TI
Sbjct: 1211 ERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITI 1270

Query: 1312 ALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLL 1371
            A+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVVALG   GE AYL+SSWN+LDGLL
Sbjct: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330

Query: 1372 VLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIG 1431
            VL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL+SSL+PIG
Sbjct: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390

Query: 1432 NIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLG 1491
            NIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+ K+ C  A YRWVR KYNFDNLG
Sbjct: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLG 1450

Query: 1492 QALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFV 1551
            QALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHNPWMLLYFISFLLIV+FFVLNMFV
Sbjct: 1451 QALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFV 1510

Query: 1552 GVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPS-PEAQRRPYYADYSPTRRSI 1610
            GVVVENFHKCRQHQE EEARRREEKRLRRLE++RRS      EAQ +PYY+DYS  R  +
Sbjct: 1511 GVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLV 1570

Query: 1611 HSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVA 1670
            H LCTSHYLDLFIT +I +NV+TM+MEHY QP+ LDEALK CNY+FT++FV E+  KLVA
Sbjct: 1571 HHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVA 1630

Query: 1671 FGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLK 1730
            FGFRRFF+DRWNQLDLAIVLLS+MGITLEEIE++A+LPINPTIIRIMRVLRIARVLKLLK
Sbjct: 1631 FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLK 1690

Query: 1731 MATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHAT 1790
            MA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG LEC E +PCEGL RHAT
Sbjct: 1691 MAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHAT 1750

Query: 1791 FSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFV 1850
            F NFGMAFLTLFRVSTGDNWNGIMKDTLR+C   D+    Y   +SP+YFV+FVL AQFV
Sbjct: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC---DQESTCYNTVISPIYFVSFVLTAQFV 1807

Query: 1851 LVNVVVAVLMKHLEESNKEAREDAELDAEIELEM-------------------AQGPG-- 1889
            LVNVV+AVLMKHLEESNKEA+E+AEL+AE+ELEM                    +GP   
Sbjct: 1808 LVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSP 1867

Query: 1890 ---------------SARRVDADRP---PLPQESPGARDAPNLV-ARKVSVSRMLSLPND 1930
                           SA     + P   P P E PG    P+L+  RK  VSR  SLPND
Sbjct: 1868 DSPKPGALHPAAHARSASHFSLEHPTMQPHPTELPG----PDLLTVRKSGVSRTHSLPND 1923

Query: 1931 SYMFRPVVPASAPHPRPLQEVEMETYGAGTP---LGSVASVHSPPAESCASLQIP----- 1982
            SYM R    A  P         +   G G P    GSV SVHS PA++   LQ+P     
Sbjct: 1924 SYMCRHGSTAEGP---------LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH 1974

Query: 1983 LAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGK-IDSPRDTLDPAEPG 2041
            L     A +   +  L P G  RSP   R L RQ A+ TDSL+ + + S  D L   EP 
Sbjct: 1975 LLQPHSAPTWGTIPKLPPPG--RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEEEPP 2032

Query: 2042 EKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPAD 2098
                ++        QS  R P       R+H+    C+ S     G +    +DP++
Sbjct: 2033 SPRDLKK-CYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDS-----GSQPHLGTDPSN 2083


>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
            isoform 3 [Homo sapiens]
          Length = 2343

 Score = 2263 bits (5864), Expect = 0.0
 Identities = 1334/2422 (55%), Positives = 1557/2422 (64%), Gaps = 207/2422 (8%)

Query: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66

Query: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186

Query: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246

Query: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305

Query: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418

Query: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478

Query: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536

Query: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592

Query: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642

Query: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696

Query: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740

Query: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800

Query: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860

Query: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919

Query: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTD 1030
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S+++
Sbjct: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979

Query: 1031 EDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKS 1090
             D  S   + D  +         K C   V+   H E R SL PPLI+ TAATPM  PKS
Sbjct: 980  PDFFSPSLDGDGDR---------KKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKS 1030

Query: 1091 SPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSL 1148
            +         P SRR SSS    P    + K P S RSSP +PW  + +W+SRRSS +SL
Sbjct: 1031 TSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSL 1090

Query: 1149 GRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAA 1208
            GRAPSLKRR   GER SLLSGEG+ S D+E         P  +  R   SL+        
Sbjct: 1091 GRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFD 1150

Query: 1209 LPPT-----------------KCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCC 1251
            LP T                 + +D +G+  +      LR D    D  + DD+   S  
Sbjct: 1151 LPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKG 1210

Query: 1252 LRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTI 1311
             R+   +    P  C  R++W+ Y+F PQ+RFR+ C ++ITHKMFDHVVLV IFLNC+TI
Sbjct: 1211 ERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITI 1270

Query: 1312 ALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLL 1371
            A+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVVALG   GE AYL+SSWN+LDGLL
Sbjct: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330

Query: 1372 VLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIG 1431
            VL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL+SSL+PIG
Sbjct: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390

Query: 1432 NIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLG 1491
            NIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+ K+ C  A YRWVR KYNFDNLG
Sbjct: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLG 1450

Query: 1492 QALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFV 1551
            QALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHNPWMLLYFISFLLIV+FFVLNMFV
Sbjct: 1451 QALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFV 1510

Query: 1552 GVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPS-PEAQRRPYYADYSPTRRSI 1610
            GVVVENFHKCRQHQE EEARRREEKRLRRLE++RRS      EAQ +PYY+DYS  R  +
Sbjct: 1511 GVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLV 1570

Query: 1611 HSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVA 1670
            H LCTSHYLDLFIT +I +NV+TM+MEHY QP+ LDEALK CNY+FT++FV E+  KLVA
Sbjct: 1571 HHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVA 1630

Query: 1671 FGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLK 1730
            FGFRRFF+DRWNQLDLAIVLLS+MGITLEEIE++A+LPINPTIIRIMRVLRIARVLKLLK
Sbjct: 1631 FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLK 1690

Query: 1731 MATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHAT 1790
            MA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG LEC E +PCEGL RHAT
Sbjct: 1691 MAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHAT 1750

Query: 1791 FSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFV 1850
            F NFGMAFLTLFRVSTGDNWNGIMKDTLR+C   D+    Y   +SP+YFV+FVL AQFV
Sbjct: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC---DQESTCYNTVISPIYFVSFVLTAQFV 1807

Query: 1851 LVNVVVAVLMKHLEESNKEAREDAELDAEIELEM-------------------AQGPGSA 1891
            LVNVV+AVLMKHLEESNKEA+E+AEL+AE+ELEM                    +GP S 
Sbjct: 1808 LVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSP 1867

Query: 1892 RRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPV---VPASAPHPRPL 1948
               D+ +P     +  AR A +           L  P D  +F  +   +  S      L
Sbjct: 1868 ---DSPKPGALHPAAHARSASHF---------SLEHPTDRQLFDTISLLIQGSLEWELKL 1915

Query: 1949 QEVEMETYGAGTPLGSVASVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARS-P 2007
             +   E  G G   G  ++  S P+   +  QIPLA          + ALS      S P
Sbjct: 1916 MD---ELAGPG---GQPSAFPSAPSLGGSDPQIPLA---------EMEALSLTSEIVSEP 1960

Query: 2008 SLSRLLCRQ---EAVHT---DSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQSPPRS 2061
            S S  L      + +HT    +LE  +  P  T  P           V++  SL +    
Sbjct: 1961 SCSLALTDDSLPDDMHTLLLSALESNM-QPHPTELPGPDLLTVRKSGVSRTHSLPNDSYM 2019

Query: 2062 PRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPAD--------EEVSHITS--SACPW 2111
             R  S  T +   G R      A  G   +  S PAD        ++  H+    SA  W
Sbjct: 2020 CRHGS--TAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTW 2077

Query: 2112 QPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAELGSGEPGEAKA- 2170
                +   P  SP+A  +R LRR  ++     LD  G    +    AE+    P  A+A 
Sbjct: 2078 GTIPKLPPPGRSPLA--QRPLRRQAAIRTDS-LDVQGLGSRE-DLLAEVSGPSPPLARAY 2133

Query: 2171 --WGPEAEPALGARR-----KKKMSP--PCISVEPPAEDEGSARPSAAEGGSTTLRRRTP 2221
              WG  +  A    R      K M+P  PC   EP   + G   P               
Sbjct: 2134 SFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEP---NWGKGPPETRSSLELDTELSWI 2190

Query: 2222 SCEATPHRDSLEP-----------TEGSGAGGDPAA---KGERWGQASCRAEHLTVPSFA 2267
            S +  P     EP            E       P +   +  R   A    +  + P   
Sbjct: 2191 SGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLG 2250

Query: 2268 FEPLDL-GVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGDPPE-KRRGLY 2325
             +P +L G P G P       ++P S        + ++PPES+ P     P    RR   
Sbjct: 2251 TDPSNLGGQPLGGPGSRPKKKLSPPS--------ITIDPPESQGPRTPPSPGICLRRRAP 2302

Query: 2326 LTVPQCPLEK--PGSPSATPAP 2345
             +  + PL    P S +A+P+P
Sbjct: 2303 SSDSKDPLASGPPDSMAASPSP 2324



 Score =  108 bits (269), Expect = 8e-23
 Identities = 127/405 (31%), Positives = 177/405 (43%), Gaps = 71/405 (17%)

Query: 1894 VDADRPPLPQESPGARDAPNLVA-RKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVE 1952
            ++++  P P E PG    P+L+  RK  VSR  SLPNDSYM R    A  P         
Sbjct: 1983 LESNMQPHPTELPG----PDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGP--------- 2029

Query: 1953 METYGAGTPL---GSVASVHSPPAESCASLQIP-----LAVSSPARSGEPLHALSPRGTA 2004
            +   G G P    GSV SVHS PA++   LQ+P     L     A +   +  L P G  
Sbjct: 2030 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPG-- 2087

Query: 2005 RSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQSPPRSPRP 2064
            RSP   R L RQ A+ TDSL+ +    R+ L     G   P  P+ +  S     +S   
Sbjct: 2088 RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSG---PSPPLARAYSFWG--QSSTQ 2142

Query: 2065 ASVRTRKHTFGQRCVSSRPAAPGGE--------EAEASDPADEEVSHITSSACPWQPTAE 2116
            A   +R H+   + ++     PG E        E  +S   D E+S I+    P      
Sbjct: 2143 AQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLP------ 2196

Query: 2117 PHGPEASPVAGGERDLRRLYSVDAQGFLDKPGR-ADEQWRPSAELGSGEPGEAKAWGPE- 2174
            P G E  P     RDL++ YSV+AQ    +P    DEQ R S  +   + G     G + 
Sbjct: 2197 PGGQEEPP---SPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDP 2253

Query: 2175 ----AEP--ALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPH 2228
                 +P    G+R KKK+SPP I+++PP E +G   P +       LRRR PS      
Sbjct: 2254 SNLGGQPLGGPGSRPKKKLSPPSITIDPP-ESQGPRTPPSP---GICLRRRAPS------ 2303

Query: 2229 RDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDL 2273
             DS +P     A G P +        S + + L++   + +P DL
Sbjct: 2304 SDSKDPL----ASGPPDSMA---ASPSPKKDVLSLSGLSSDPADL 2341


>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
            isoform 7 [Homo sapiens]
          Length = 2298

 Score = 2261 bits (5858), Expect = 0.0
 Identities = 1320/2375 (55%), Positives = 1536/2375 (64%), Gaps = 192/2375 (8%)

Query: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66

Query: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186

Query: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246

Query: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305

Query: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418

Query: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478

Query: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536

Query: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592

Query: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642

Query: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696

Query: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740

Query: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800

Query: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860

Query: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919

Query: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTD 1030
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S+++
Sbjct: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979

Query: 1031 EDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKS 1090
             D  S   + D  +         K C   V+   H E R SL PPLI+ TAATPM  PKS
Sbjct: 980  PDFFSPSLDGDGDR---------KKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKS 1030

Query: 1091 SPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSL 1148
            +         P SRR SSS    P    + K P S RSSP +PW  + +W+SRRSS +SL
Sbjct: 1031 TSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSL 1090

Query: 1149 GRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAA 1208
            GRAPSLKRR   GER SLLSGEG+ S D+E         P  +  R   SL+        
Sbjct: 1091 GRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFD 1150

Query: 1209 LPPT-----------------KCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCC 1251
            LP T                 + +D +G+  +      LR D    D  + DD+   S  
Sbjct: 1151 LPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKG 1210

Query: 1252 LRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTI 1311
             R+   +    P  C  R++W+ Y+F PQ+RFR+ C ++ITHKMFDHVVLV IFLNC+TI
Sbjct: 1211 ERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITI 1270

Query: 1312 ALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLL 1371
            A+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVVALG   GE AYL+SSWN+LDGLL
Sbjct: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330

Query: 1372 VLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIG 1431
            VL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL+SSL+PIG
Sbjct: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390

Query: 1432 NIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLG 1491
            NIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+ K+ C  A YRWVR KYNFDNLG
Sbjct: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLG 1450

Query: 1492 QALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFV 1551
            QALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHNPWMLLYFISFLLIV+FFVLNMFV
Sbjct: 1451 QALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFV 1510

Query: 1552 GVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPS-PEAQRRPYYADYSPTRRSI 1610
            GVVVENFHKCRQHQE EEARRREEKRLRRLE++RRS      EAQ +PYY+DYS  R  +
Sbjct: 1511 GVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLV 1570

Query: 1611 HSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVA 1670
            H LCTSHYLDLFIT +I +NV+TM+MEHY QP+ LDEALK CNY+FT++FV E+  KLVA
Sbjct: 1571 HHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVA 1630

Query: 1671 FGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLK 1730
            FGFRRFF+DRWNQLDLAIVLLS+MGITLEEIE++A+LPINPTIIRIMRVLRIARVLKLLK
Sbjct: 1631 FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLK 1690

Query: 1731 MATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHAT 1790
            MA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG LEC E +PCEGL RHAT
Sbjct: 1691 MAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHAT 1750

Query: 1791 FSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFV 1850
            F NFGMAFLTLFRVSTGDNWNGIMKDTLR+C   D+    Y   +SP+YFV+FVL AQFV
Sbjct: 1751 FRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC---DQESTCYNTVISPIYFVSFVLTAQFV 1807

Query: 1851 LVNVVVAVLMKHLEESNKEAREDAELDAEIELEM-------------------AQGPGSA 1891
            LVNVV+AVLMKHLEESNKEA+E+AEL+AE+ELEM                    +GP S 
Sbjct: 1808 LVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSP 1867

Query: 1892 RRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPV---VPASAPHPRPL 1948
               D+ +P     +  AR A +           L  P D  +F  +   +  S      L
Sbjct: 1868 ---DSPKPGALHPAAHARSASHF---------SLEHPTDRQLFDTISLLIQGSLEWELKL 1915

Query: 1949 QEVEMETYGAGTPLGSVASVHSPPAESCASLQI-PLAVSSPARSGEPLHALSPRGTARSP 2007
             +   E  G G   G  ++  S P+   +  Q+ P     P   G  L  +   G +R+ 
Sbjct: 1916 MD---ELAGPG---GQPSAFPSAPSLGGSDPQMQPHPTELP---GPDLLTVRKSGVSRTH 1966

Query: 2008 SL--SRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPV--RPVTQGGSLQSPPRSPR 2063
            SL     +CR    H  + EG +      L  A+ G    V  +P      LQ P  +P 
Sbjct: 1967 SLPNDSYMCR----HGSTAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPH 2022

Query: 2064 PASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSS------ACPWQPTAEP 2117
                 +   T+G   +   P  P G    A  P   + +  T S             AE 
Sbjct: 2023 LLQPHSAP-TWG--TIPKLP--PPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEV 2077

Query: 2118 HGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAELGSGEPGEAKAWGPEAEP 2177
             GP  SP            S  AQ       +  +   P A     EP   K   PE   
Sbjct: 2078 SGP--SPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKG-PPETRS 2134

Query: 2178 ALGARRKKK-----MSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSL 2232
            +L    +       + PP    EPP+  +     S     + + +RR  S      R S+
Sbjct: 2135 SLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVE---AQSCQRRPTSWLDEQRRHSI 2191

Query: 2233 ---------EP---TEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDP 2280
                     +P   T+ S  GG P       G  S   + L+ PS   +P +   P   P
Sbjct: 2192 AVSCLDSGSQPHLGTDPSNLGGQPLG-----GPGSRPKKKLSPPSITIDPPESQGPRTPP 2246

Query: 2281 FLDGSHSVTPESRASSSGAIVPLE--PPESEPPMP 2313
                S  +    RA SS +  PL   PP+S    P
Sbjct: 2247 ----SPGICLRRRAPSSDSKDPLASGPPDSMAASP 2277



 Score =  108 bits (271), Expect = 5e-23
 Identities = 135/431 (31%), Positives = 184/431 (42%), Gaps = 76/431 (17%)

Query: 1876 LDAEIEL--EMAQGPGSARRVDADRPPL----PQESPGARDAPN---LVARKVSVSRMLS 1926
            L+ E++L  E+A GPG         P L    PQ  P   + P    L  RK  VSR  S
Sbjct: 1909 LEWELKLMDELA-GPGGQPSAFPSAPSLGGSDPQMQPHPTELPGPDLLTVRKSGVSRTHS 1967

Query: 1927 LPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPL---GSVASVHSPPAESCASLQIP- 1982
            LPNDSYM R    A  P         +   G G P    GSV SVHS PA++   LQ+P 
Sbjct: 1968 LPNDSYMCRHGSTAEGP---------LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPK 2018

Query: 1983 ----LAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPA 2038
                L     A +   +  L P G  RSP   R L RQ A+ TDSL+ +    R+ L   
Sbjct: 2019 DAPHLLQPHSAPTWGTIPKLPPPG--RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAE 2076

Query: 2039 EPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGE--------E 2090
              G   P  P+ +  S     +S   A   +R H+   + ++     PG E        E
Sbjct: 2077 VSG---PSPPLARAYSFWG--QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPE 2131

Query: 2091 AEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGR- 2149
              +S   D E+S I+    P      P G E  P     RDL++ YSV+AQ    +P   
Sbjct: 2132 TRSSLELDTELSWISGDLLP------PGGQEEPP---SPRDLKKCYSVEAQSCQRRPTSW 2182

Query: 2150 ADEQWRPSAELGSGEPGEAKAWGPE-----AEP--ALGARRKKKMSPPCISVEPPAEDEG 2202
             DEQ R S  +   + G     G +      +P    G+R KKK+SPP I+++PP E +G
Sbjct: 2183 LDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPP-ESQG 2241

Query: 2203 SARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLT 2262
               P +       LRRR PS       DS +P     A G P +        S + + L+
Sbjct: 2242 PRTPPSP---GICLRRRAPS------SDSKDPL----ASGPPDSMA---ASPSPKKDVLS 2285

Query: 2263 VPSFAFEPLDL 2273
            +   + +P DL
Sbjct: 2286 LSGLSSDPADL 2296


>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
            isoform 2 [Homo sapiens]
          Length = 2354

 Score = 2260 bits (5856), Expect = 0.0
 Identities = 1334/2433 (54%), Positives = 1558/2433 (64%), Gaps = 218/2433 (8%)

Query: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66

Query: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186

Query: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246

Query: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305

Query: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418

Query: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478

Query: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536

Query: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592

Query: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642

Query: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696

Query: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740

Query: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800

Query: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860

Query: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919

Query: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTD 1030
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAEGDAN+S+++
Sbjct: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEGDANKSESE 979

Query: 1031 EDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKS 1090
             D  S   + D  +         K C   V+   H E R SL PPLI+ TAATPM  PKS
Sbjct: 980  PDFFSPSLDGDGDR---------KKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKS 1030

Query: 1091 SPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSL 1148
            +         P SRR SSS    P    + K P S RSSP +PW  + +W+SRRSS +SL
Sbjct: 1031 TSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSL 1090

Query: 1149 GRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAA 1208
            GRAPSLKRR   GER SLLSGEG+ S D+E         P  +  R   SL+        
Sbjct: 1091 GRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFD 1150

Query: 1209 LPPT-----------------KCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCC 1251
            LP T                 + +D +G+  +      LR D    D  + DD+   S  
Sbjct: 1151 LPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKG 1210

Query: 1252 LRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTI 1311
             R+   +    P  C  R++W+ Y+F PQ+RFR+ C ++ITHKMFDHVVLV IFLNC+TI
Sbjct: 1211 ERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITI 1270

Query: 1312 ALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLL 1371
            A+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVVALG   GE AYL+SSWN+LDGLL
Sbjct: 1271 AMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLL 1330

Query: 1372 VLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIG 1431
            VL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLRVISRA GLKLVVETL+SSL+PIG
Sbjct: 1331 VLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1390

Query: 1432 NIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLG 1491
            NIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+ K+ C  A YRWVR KYNFDNLG
Sbjct: 1391 NIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLG 1450

Query: 1492 QALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFV 1551
            QALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHNPWMLLYFISFLLIV+FFVLNMFV
Sbjct: 1451 QALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFV 1510

Query: 1552 GVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR------------STFPSPEAQRRPY 1599
            GVVVENFHKCRQHQE EEARRREEKRLRRLE++RR            S   + EAQ +PY
Sbjct: 1511 GVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPY 1570

Query: 1600 YADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIV 1659
            Y+DYS  R  +H LCTSHYLDLFIT +I +NV+TM+MEHY QP+ LDEALK CNY+FT++
Sbjct: 1571 YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVI 1630

Query: 1660 FVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRV 1719
            FV E+  KLVAFGFRRFF+DRWNQLDLAIVLLS+MGITLEEIE++A+LPINPTIIRIMRV
Sbjct: 1631 FVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRV 1690

Query: 1720 LRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSED 1779
            LRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALGVELFG LEC E 
Sbjct: 1691 LRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDET 1750

Query: 1780 NPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVY 1839
            +PCEGL RHATF NFGMAFLTLFRVSTGDNWNGIMKDTLR+C   D+    Y   +SP+Y
Sbjct: 1751 HPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC---DQESTCYNTVISPIY 1807

Query: 1840 FVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEM--------------- 1884
            FV+FVL AQFVLVNVV+AVLMKHLEESNKEA+E+AEL+AE+ELEM               
Sbjct: 1808 FVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPF 1867

Query: 1885 ----AQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPV--- 1937
                 +GP S    D+ +P     +  AR A +           L  P D  +F  +   
Sbjct: 1868 LWPGVEGPDSP---DSPKPGALHPAAHARSASHF---------SLEHPTDRQLFDTISLL 1915

Query: 1938 VPASAPHPRPLQEVEMETYGAGTPLGSVASVHSPPAESCASLQIPLAVSSPARSGEPLHA 1997
            +  S      L +   E  G G   G  ++  S P+   +  QIPLA          + A
Sbjct: 1916 IQGSLEWELKLMD---ELAGPG---GQPSAFPSAPSLGGSDPQIPLA---------EMEA 1960

Query: 1998 LSPRGTARS-PSLSRLLCRQ---EAVHT---DSLEGKIDSPRDTLDPAEPGEKTPVRPVT 2050
            LS      S PS S  L      + +HT    +LE  +  P  T  P           V+
Sbjct: 1961 LSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNM-QPHPTELPGPDLLTVRKSGVS 2019

Query: 2051 QGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPAD--------EEVS 2102
            +  SL +     R  S  T +   G R      A  G   +  S PAD        ++  
Sbjct: 2020 RTHSLPNDSYMCRHGS--TAEGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAP 2077

Query: 2103 HITS--SACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAEL 2160
            H+    SA  W    +   P  SP+A  +R LRR  ++     LD  G    +    AE+
Sbjct: 2078 HLLQPHSAPTWGTIPKLPPPGRSPLA--QRPLRRQAAIRTDS-LDVQGLGSRE-DLLAEV 2133

Query: 2161 GSGEPGEAKA---WGPEAEPALGARR-----KKKMSP--PCISVEPPAEDEGSARPSAAE 2210
                P  A+A   WG  +  A    R      K M+P  PC   EP   + G   P    
Sbjct: 2134 SGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEP---NWGKGPPETRS 2190

Query: 2211 GGSTTLRRRTPSCEATPHRDSLEP-----------TEGSGAGGDPAA---KGERWGQASC 2256
                       S +  P     EP            E       P +   +  R   A  
Sbjct: 2191 SLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVS 2250

Query: 2257 RAEHLTVPSFAFEPLDL-GVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVG 2315
              +  + P    +P +L G P G P       ++P S        + ++PPES+ P    
Sbjct: 2251 CLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPS--------ITIDPPESQGPRTPP 2302

Query: 2316 DPPE-KRRGLYLTVPQCPLEK--PGSPSATPAP 2345
             P    RR    +  + PL    P S +A+P+P
Sbjct: 2303 SPGICLRRRAPSSDSKDPLASGPPDSMAASPSP 2335



 Score =  108 bits (269), Expect = 8e-23
 Identities = 127/405 (31%), Positives = 177/405 (43%), Gaps = 71/405 (17%)

Query: 1894 VDADRPPLPQESPGARDAPNLVA-RKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVE 1952
            ++++  P P E PG    P+L+  RK  VSR  SLPNDSYM R    A  P         
Sbjct: 1994 LESNMQPHPTELPG----PDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGP--------- 2040

Query: 1953 METYGAGTPL---GSVASVHSPPAESCASLQIP-----LAVSSPARSGEPLHALSPRGTA 2004
            +   G G P    GSV SVHS PA++   LQ+P     L     A +   +  L P G  
Sbjct: 2041 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPG-- 2098

Query: 2005 RSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQSPPRSPRP 2064
            RSP   R L RQ A+ TDSL+ +    R+ L     G   P  P+ +  S     +S   
Sbjct: 2099 RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSG---PSPPLARAYSFWG--QSSTQ 2153

Query: 2065 ASVRTRKHTFGQRCVSSRPAAPGGE--------EAEASDPADEEVSHITSSACPWQPTAE 2116
            A   +R H+   + ++     PG E        E  +S   D E+S I+    P      
Sbjct: 2154 AQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLP------ 2207

Query: 2117 PHGPEASPVAGGERDLRRLYSVDAQGFLDKPGR-ADEQWRPSAELGSGEPGEAKAWGPE- 2174
            P G E  P     RDL++ YSV+AQ    +P    DEQ R S  +   + G     G + 
Sbjct: 2208 PGGQEEPP---SPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDP 2264

Query: 2175 ----AEP--ALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPH 2228
                 +P    G+R KKK+SPP I+++PP E +G   P +       LRRR PS      
Sbjct: 2265 SNLGGQPLGGPGSRPKKKLSPPSITIDPP-ESQGPRTPPSP---GICLRRRAPS------ 2314

Query: 2229 RDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDL 2273
             DS +P     A G P +        S + + L++   + +P DL
Sbjct: 2315 SDSKDPL----ASGPPDSMA---ASPSPKKDVLSLSGLSSDPADL 2352


>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
            isoform 5 [Homo sapiens]
          Length = 2321

 Score = 2248 bits (5824), Expect = 0.0
 Identities = 1320/2398 (55%), Positives = 1536/2398 (64%), Gaps = 215/2398 (8%)

Query: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66

Query: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186

Query: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246

Query: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305

Query: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418

Query: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478

Query: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536

Query: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592

Query: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642

Query: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696

Query: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740

Query: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800

Query: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860

Query: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919

Query: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE--------- 1021
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAE         
Sbjct: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979

Query: 1022 --------------GDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLE 1067
                          GDAN+S+++ D  S   + D  +         K C   V+   H E
Sbjct: 980  GQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDR---------KKCLALVSLGEHPE 1030

Query: 1068 GRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLR 1125
             R SL PPLI+ TAATPM  PKS+         P SRR SSS    P    + K P S R
Sbjct: 1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR 1090

Query: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAA 1185
            SSP +PW  + +W+SRRSS +SLGRAPSLKRR   GER SLLSGEG+ S D+E       
Sbjct: 1091 SSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEER 1150

Query: 1186 PGPRATPLRRAESLDPRPLRPAALPPT-----------------KCRDRDGQVVALPSDF 1228
              P  +  R   SL+        LP T                 + +D +G+  +     
Sbjct: 1151 ASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLAR 1210

Query: 1229 FLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQ 1288
             LR D    D  + DD+   S   R+   +    P  C  R++W+ Y+F PQ+RFR+ C 
Sbjct: 1211 ALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCH 1270

Query: 1289 KVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVV 1348
            ++ITHKMFDHVVLV IFLNC+TIA+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVV
Sbjct: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330

Query: 1349 ALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLR 1408
            ALG   GE AYL+SSWN+LDGLLVL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLR
Sbjct: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390

Query: 1409 VISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468
            VISRA GLKLVVETL+SSL+PIGNIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+
Sbjct: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450

Query: 1469 TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHN 1528
             K+ C  A YRWVR KYNFDNLGQALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHN
Sbjct: 1451 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1510

Query: 1529 PWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRST 1588
            PWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLE++RRS 
Sbjct: 1511 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRSK 1570

Query: 1589 FPS-PEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDE 1647
                 EAQ +PYY+DYS  R  +H LCTSHYLDLFIT +I +NV+TM+MEHY QP+ LDE
Sbjct: 1571 EKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDE 1630

Query: 1648 ALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAAL 1707
            ALK CNY+FT++FV E+  KLVAFGFRRFF+DRWNQLDLAIVLLS+MGITLEEIE++A+L
Sbjct: 1631 ALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASL 1690

Query: 1708 PINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALG 1767
            PINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLFMLLFFI+AALG
Sbjct: 1691 PINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALG 1750

Query: 1768 VELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKH 1827
            VELFG LEC E +PCEGL RHATF NFGMAFLTLFRVSTGDNWNGIMKDTLR+C   D+ 
Sbjct: 1751 VELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDC---DQE 1807

Query: 1828 CLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEM--- 1884
               Y   +SP+YFV+FVL AQFVLVNVV+AVLMKHLEESNKEA+E+AEL+AE+ELEM   
Sbjct: 1808 STCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTL 1867

Query: 1885 ----------------AQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLP 1928
                             +GP S    D+ +P     +  AR A +           L  P
Sbjct: 1868 SPQPHSPLGSPFLWPGVEGPDSP---DSPKPGALHPAAHARSASHF---------SLEHP 1915

Query: 1929 NDSYMFRPV---VPASAPHPRPLQEVEMETYGAGTPLGSVASVHSPPAESCASLQI-PLA 1984
             D  +F  +   +  S      L +   E  G G   G  ++  S P+   +  Q+ P  
Sbjct: 1916 TDRQLFDTISLLIQGSLEWELKLMD---ELAGPG---GQPSAFPSAPSLGGSDPQMQPHP 1969

Query: 1985 VSSPARSGEPLHALSPRGTARSPSL--SRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGE 2042
               P   G  L  +   G +R+ SL     +CR    H  + EG +      L  A+ G 
Sbjct: 1970 TELP---GPDLLTVRKSGVSRTHSLPNDSYMCR----HGSTAEGPLGHRGWGLPKAQSGS 2022

Query: 2043 KTPV--RPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEE 2100
               V  +P      LQ P  +P      +   T+G   +   P  P G    A  P   +
Sbjct: 2023 VLSVHSQPADTSYILQLPKDAPHLLQPHSAP-TWG--TIPKLP--PPGRSPLAQRPLRRQ 2077

Query: 2101 VSHITSS------ACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQW 2154
             +  T S             AE  GP  SP            S  AQ       +  +  
Sbjct: 2078 AAIRTDSLDVQGLGSREDLLAEVSGP--SPPLARAYSFWGQSSTQAQQHSRSHSKISKHM 2135

Query: 2155 RPSAELGSGEPGEAKAWGPEAEPALGARRKKK-----MSPPCISVEPPAEDEGSARPSAA 2209
             P A     EP   K   PE   +L    +       + PP    EPP+  +     S  
Sbjct: 2136 TPPAPCPGPEPNWGKG-PPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVE 2194

Query: 2210 EGGSTTLRRRTPSCEATPHRDSL---------EP---TEGSGAGGDPAAKGERWGQASCR 2257
               + + +RR  S      R S+         +P   T+ S  GG P       G  S  
Sbjct: 2195 ---AQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLG-----GPGSRP 2246

Query: 2258 AEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLE--PPESEPPMP 2313
             + L+ PS   +P +   P   P    S  +    RA SS +  PL   PP+S    P
Sbjct: 2247 KKKLSPPSITIDPPESQGPRTPP----SPGICLRRRAPSSDSKDPLASGPPDSMAASP 2300



 Score =  108 bits (271), Expect = 5e-23
 Identities = 135/431 (31%), Positives = 184/431 (42%), Gaps = 76/431 (17%)

Query: 1876 LDAEIEL--EMAQGPGSARRVDADRPPL----PQESPGARDAPN---LVARKVSVSRMLS 1926
            L+ E++L  E+A GPG         P L    PQ  P   + P    L  RK  VSR  S
Sbjct: 1932 LEWELKLMDELA-GPGGQPSAFPSAPSLGGSDPQMQPHPTELPGPDLLTVRKSGVSRTHS 1990

Query: 1927 LPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPL---GSVASVHSPPAESCASLQIP- 1982
            LPNDSYM R    A  P         +   G G P    GSV SVHS PA++   LQ+P 
Sbjct: 1991 LPNDSYMCRHGSTAEGP---------LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPK 2041

Query: 1983 ----LAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPA 2038
                L     A +   +  L P G  RSP   R L RQ A+ TDSL+ +    R+ L   
Sbjct: 2042 DAPHLLQPHSAPTWGTIPKLPPPG--RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAE 2099

Query: 2039 EPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGE--------E 2090
              G   P  P+ +  S     +S   A   +R H+   + ++     PG E        E
Sbjct: 2100 VSG---PSPPLARAYSFWG--QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPE 2154

Query: 2091 AEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGR- 2149
              +S   D E+S I+    P      P G E  P     RDL++ YSV+AQ    +P   
Sbjct: 2155 TRSSLELDTELSWISGDLLP------PGGQEEPP---SPRDLKKCYSVEAQSCQRRPTSW 2205

Query: 2150 ADEQWRPSAELGSGEPGEAKAWGPE-----AEP--ALGARRKKKMSPPCISVEPPAEDEG 2202
             DEQ R S  +   + G     G +      +P    G+R KKK+SPP I+++PP E +G
Sbjct: 2206 LDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPP-ESQG 2264

Query: 2203 SARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLT 2262
               P +       LRRR PS       DS +P     A G P +        S + + L+
Sbjct: 2265 PRTPPSP---GICLRRRAPS------SDSKDPL----ASGPPDSMA---ASPSPKKDVLS 2308

Query: 2263 VPSFAFEPLDL 2273
            +   + +P DL
Sbjct: 2309 LSGLSSDPADL 2319


>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
            isoform 1 [Homo sapiens]
          Length = 2377

 Score = 2247 bits (5822), Expect = 0.0
 Identities = 1334/2456 (54%), Positives = 1558/2456 (63%), Gaps = 241/2456 (9%)

Query: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66

Query: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186

Query: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246

Query: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305

Query: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418

Query: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478

Query: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536

Query: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592

Query: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642

Query: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696

Query: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740

Query: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800

Query: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860

Query: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919

Query: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE--------- 1021
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAE         
Sbjct: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979

Query: 1022 --------------GDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLE 1067
                          GDAN+S+++ D  S   + D  +         K C   V+   H E
Sbjct: 980  GQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDR---------KKCLALVSLGEHPE 1030

Query: 1068 GRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLR 1125
             R SL PPLI+ TAATPM  PKS+         P SRR SSS    P    + K P S R
Sbjct: 1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR 1090

Query: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAA 1185
            SSP +PW  + +W+SRRSS +SLGRAPSLKRR   GER SLLSGEG+ S D+E       
Sbjct: 1091 SSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEER 1150

Query: 1186 PGPRATPLRRAESLDPRPLRPAALPPT-----------------KCRDRDGQVVALPSDF 1228
              P  +  R   SL+        LP T                 + +D +G+  +     
Sbjct: 1151 ASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLAR 1210

Query: 1229 FLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQ 1288
             LR D    D  + DD+   S   R+   +    P  C  R++W+ Y+F PQ+RFR+ C 
Sbjct: 1211 ALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCH 1270

Query: 1289 KVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVV 1348
            ++ITHKMFDHVVLV IFLNC+TIA+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVV
Sbjct: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330

Query: 1349 ALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLR 1408
            ALG   GE AYL+SSWN+LDGLLVL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLR
Sbjct: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390

Query: 1409 VISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468
            VISRA GLKLVVETL+SSL+PIGNIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+
Sbjct: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450

Query: 1469 TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHN 1528
             K+ C  A YRWVR KYNFDNLGQALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHN
Sbjct: 1451 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1510

Query: 1529 PWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR-- 1586
            PWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLE++RR  
Sbjct: 1511 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNL 1570

Query: 1587 ----------STFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSM 1636
                      S   + EAQ +PYY+DYS  R  +H LCTSHYLDLFIT +I +NV+TM+M
Sbjct: 1571 MLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1630

Query: 1637 EHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI 1696
            EHY QP+ LDEALK CNY+FT++FV E+  KLVAFGFRRFF+DRWNQLDLAIVLLS+MGI
Sbjct: 1631 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1690

Query: 1697 TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1756
            TLEEIE++A+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLF
Sbjct: 1691 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1750

Query: 1757 MLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKD 1816
            MLLFFI+AALGVELFG LEC E +PCEGL RHATF NFGMAFLTLFRVSTGDNWNGIMKD
Sbjct: 1751 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1810

Query: 1817 TLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAEL 1876
            TLR+C   D+    Y   +SP+YFV+FVL AQFVLVNVV+AVLMKHLEESNKEA+E+AEL
Sbjct: 1811 TLRDC---DQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1867

Query: 1877 DAEIELEM-------------------AQGPGSARRVDADRPPLPQESPGARDAPNLVAR 1917
            +AE+ELEM                    +GP S    D+ +P     +  AR A +    
Sbjct: 1868 EAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSP---DSPKPGALHPAAHARSASHF--- 1921

Query: 1918 KVSVSRMLSLPNDSYMFRPV---VPASAPHPRPLQEVEMETYGAGTPLGSVASVHSPPAE 1974
                   L  P D  +F  +   +  S      L +   E  G G   G  ++  S P+ 
Sbjct: 1922 ------SLEHPTDRQLFDTISLLIQGSLEWELKLMD---ELAGPG---GQPSAFPSAPSL 1969

Query: 1975 SCASLQIPLAVSSPARSGEPLHALSPRGTARS-PSLSRLLCRQ---EAVHT---DSLEGK 2027
              +  QIPLA          + ALS      S PS S  L      + +HT    +LE  
Sbjct: 1970 GGSDPQIPLA---------EMEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESN 2020

Query: 2028 IDSPRDTLDPAEPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPG 2087
            +  P  T  P           V++  SL +     R  S  T +   G R      A  G
Sbjct: 2021 M-QPHPTELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGS--TAEGPLGHRGWGLPKAQSG 2077

Query: 2088 GEEAEASDPAD--------EEVSHITS--SACPWQPTAEPHGPEASPVAGGERDLRRLYS 2137
               +  S PAD        ++  H+    SA  W    +   P  SP+A  +R LRR  +
Sbjct: 2078 SVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPGRSPLA--QRPLRRQAA 2135

Query: 2138 VDAQGFLDKPGRADEQWRPSAELGSGEPGEAKA---WGPEAEPALGARR-----KKKMSP 2189
            +     LD  G    +    AE+    P  A+A   WG  +  A    R      K M+P
Sbjct: 2136 IRTDS-LDVQGLGSRE-DLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTP 2193

Query: 2190 --PCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEP-----------TE 2236
              PC   EP   + G   P               S +  P     EP            E
Sbjct: 2194 PAPCPGPEP---NWGKGPPETRSSLELDTELSWISGDLLPPGGQEEPPSPRDLKKCYSVE 2250

Query: 2237 GSGAGGDPAA---KGERWGQASCRAEHLTVPSFAFEPLDL-GVPSGDPFLDGSHSVTPES 2292
                   P +   +  R   A    +  + P    +P +L G P G P       ++P S
Sbjct: 2251 AQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPS 2310

Query: 2293 RASSSGAIVPLEPPESEPPMPVGDPPE-KRRGLYLTVPQCPLEK--PGSPSATPAP 2345
                    + ++PPES+ P     P    RR    +  + PL    P S +A+P+P
Sbjct: 2311 --------ITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSP 2358



 Score =  108 bits (269), Expect = 8e-23
 Identities = 127/405 (31%), Positives = 177/405 (43%), Gaps = 71/405 (17%)

Query: 1894 VDADRPPLPQESPGARDAPNLVA-RKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVE 1952
            ++++  P P E PG    P+L+  RK  VSR  SLPNDSYM R    A  P         
Sbjct: 2017 LESNMQPHPTELPG----PDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGP--------- 2063

Query: 1953 METYGAGTPL---GSVASVHSPPAESCASLQIP-----LAVSSPARSGEPLHALSPRGTA 2004
            +   G G P    GSV SVHS PA++   LQ+P     L     A +   +  L P G  
Sbjct: 2064 LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPTWGTIPKLPPPG-- 2121

Query: 2005 RSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQSPPRSPRP 2064
            RSP   R L RQ A+ TDSL+ +    R+ L     G   P  P+ +  S     +S   
Sbjct: 2122 RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSG---PSPPLARAYSFWG--QSSTQ 2176

Query: 2065 ASVRTRKHTFGQRCVSSRPAAPGGE--------EAEASDPADEEVSHITSSACPWQPTAE 2116
            A   +R H+   + ++     PG E        E  +S   D E+S I+    P      
Sbjct: 2177 AQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPETRSSLELDTELSWISGDLLP------ 2230

Query: 2117 PHGPEASPVAGGERDLRRLYSVDAQGFLDKPGR-ADEQWRPSAELGSGEPGEAKAWGPE- 2174
            P G E  P     RDL++ YSV+AQ    +P    DEQ R S  +   + G     G + 
Sbjct: 2231 PGGQEEPP---SPRDLKKCYSVEAQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDP 2287

Query: 2175 ----AEP--ALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPH 2228
                 +P    G+R KKK+SPP I+++PP E +G   P +       LRRR PS      
Sbjct: 2288 SNLGGQPLGGPGSRPKKKLSPPSITIDPP-ESQGPRTPPSP---GICLRRRAPS------ 2337

Query: 2229 RDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDL 2273
             DS +P     A G P +        S + + L++   + +P DL
Sbjct: 2338 SDSKDPL----ASGPPDSMA---ASPSPKKDVLSLSGLSSDPADL 2375


>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
            isoform 4 [Homo sapiens]
          Length = 2332

 Score = 2244 bits (5816), Expect = 0.0
 Identities = 1320/2409 (54%), Positives = 1537/2409 (63%), Gaps = 226/2409 (9%)

Query: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66

Query: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186

Query: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246

Query: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305

Query: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418

Query: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478

Query: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536

Query: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592

Query: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642

Query: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696

Query: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740

Query: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800

Query: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860

Query: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919

Query: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE--------- 1021
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAE         
Sbjct: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979

Query: 1022 --------------GDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLE 1067
                          GDAN+S+++ D  S   + D  +         K C   V+   H E
Sbjct: 980  GQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDR---------KKCLALVSLGEHPE 1030

Query: 1068 GRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLR 1125
             R SL PPLI+ TAATPM  PKS+         P SRR SSS    P    + K P S R
Sbjct: 1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR 1090

Query: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAA 1185
            SSP +PW  + +W+SRRSS +SLGRAPSLKRR   GER SLLSGEG+ S D+E       
Sbjct: 1091 SSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEER 1150

Query: 1186 PGPRATPLRRAESLDPRPLRPAALPPT-----------------KCRDRDGQVVALPSDF 1228
              P  +  R   SL+        LP T                 + +D +G+  +     
Sbjct: 1151 ASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLAR 1210

Query: 1229 FLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQ 1288
             LR D    D  + DD+   S   R+   +    P  C  R++W+ Y+F PQ+RFR+ C 
Sbjct: 1211 ALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCH 1270

Query: 1289 KVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVV 1348
            ++ITHKMFDHVVLV IFLNC+TIA+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVV
Sbjct: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330

Query: 1349 ALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLR 1408
            ALG   GE AYL+SSWN+LDGLLVL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLR
Sbjct: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390

Query: 1409 VISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468
            VISRA GLKLVVETL+SSL+PIGNIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+
Sbjct: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450

Query: 1469 TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHN 1528
             K+ C  A YRWVR KYNFDNLGQALMSLFVL+SKDGWV+IMYDGLDAVGVDQQP+ NHN
Sbjct: 1451 NKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHN 1510

Query: 1529 PWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR-- 1586
            PWMLLYFISFLLIV+FFVLNMFVGVVVENFHKCRQHQE EEARRREEKRLRRLE++RR  
Sbjct: 1511 PWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRLEKKRRNL 1570

Query: 1587 ----------STFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSM 1636
                      S   + EAQ +PYY+DYS  R  +H LCTSHYLDLFIT +I +NV+TM+M
Sbjct: 1571 MLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAM 1630

Query: 1637 EHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI 1696
            EHY QP+ LDEALK CNY+FT++FV E+  KLVAFGFRRFF+DRWNQLDLAIVLLS+MGI
Sbjct: 1631 EHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGI 1690

Query: 1697 TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1756
            TLEEIE++A+LPINPTIIRIMRVLRIARVLKLLKMA GMRALLDTV+QALPQVGNLGLLF
Sbjct: 1691 TLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLF 1750

Query: 1757 MLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKD 1816
            MLLFFI+AALGVELFG LEC E +PCEGL RHATF NFGMAFLTLFRVSTGDNWNGIMKD
Sbjct: 1751 MLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKD 1810

Query: 1817 TLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAEL 1876
            TLR+C   D+    Y   +SP+YFV+FVL AQFVLVNVV+AVLMKHLEESNKEA+E+AEL
Sbjct: 1811 TLRDC---DQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAEL 1867

Query: 1877 DAEIELEM-------------------AQGPGSARRVDADRPPLPQESPGARDAPNLVAR 1917
            +AE+ELEM                    +GP S    D+ +P     +  AR A +    
Sbjct: 1868 EAELELEMKTLSPQPHSPLGSPFLWPGVEGPDSP---DSPKPGALHPAAHARSASHF--- 1921

Query: 1918 KVSVSRMLSLPNDSYMFRPV---VPASAPHPRPLQEVEMETYGAGTPLGSVASVHSPPAE 1974
                   L  P D  +F  +   +  S      L +   E  G G   G  ++  S P+ 
Sbjct: 1922 ------SLEHPTDRQLFDTISLLIQGSLEWELKLMD---ELAGPG---GQPSAFPSAPSL 1969

Query: 1975 SCASLQI-PLAVSSPARSGEPLHALSPRGTARSPSL--SRLLCRQEAVHTDSLEGKIDSP 2031
              +  Q+ P     P   G  L  +   G +R+ SL     +CR    H  + EG +   
Sbjct: 1970 GGSDPQMQPHPTELP---GPDLLTVRKSGVSRTHSLPNDSYMCR----HGSTAEGPLGHR 2022

Query: 2032 RDTLDPAEPGEKTPV--RPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGE 2089
               L  A+ G    V  +P      LQ P  +P      +   T+G   +   P  P G 
Sbjct: 2023 GWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAP-TWG--TIPKLP--PPGR 2077

Query: 2090 EAEASDPADEEVSHITSS------ACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGF 2143
               A  P   + +  T S             AE  GP  SP            S  AQ  
Sbjct: 2078 SPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAEVSGP--SPPLARAYSFWGQSSTQAQQH 2135

Query: 2144 LDKPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRKKK-----MSPPCISVEPPA 2198
                 +  +   P A     EP   K   PE   +L    +       + PP    EPP+
Sbjct: 2136 SRSHSKISKHMTPPAPCPGPEPNWGKG-PPETRSSLELDTELSWISGDLLPPGGQEEPPS 2194

Query: 2199 EDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSL---------EP---TEGSGAGGDPAA 2246
              +     S     + + +RR  S      R S+         +P   T+ S  GG P  
Sbjct: 2195 PRDLKKCYSVE---AQSCQRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLG 2251

Query: 2247 KGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLE-- 2304
                 G  S   + L+ PS   +P +   P   P    S  +    RA SS +  PL   
Sbjct: 2252 -----GPGSRPKKKLSPPSITIDPPESQGPRTPP----SPGICLRRRAPSSDSKDPLASG 2302

Query: 2305 PPESEPPMP 2313
            PP+S    P
Sbjct: 2303 PPDSMAASP 2311



 Score =  108 bits (271), Expect = 5e-23
 Identities = 135/431 (31%), Positives = 184/431 (42%), Gaps = 76/431 (17%)

Query: 1876 LDAEIEL--EMAQGPGSARRVDADRPPL----PQESPGARDAPN---LVARKVSVSRMLS 1926
            L+ E++L  E+A GPG         P L    PQ  P   + P    L  RK  VSR  S
Sbjct: 1943 LEWELKLMDELA-GPGGQPSAFPSAPSLGGSDPQMQPHPTELPGPDLLTVRKSGVSRTHS 2001

Query: 1927 LPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPL---GSVASVHSPPAESCASLQIP- 1982
            LPNDSYM R    A  P         +   G G P    GSV SVHS PA++   LQ+P 
Sbjct: 2002 LPNDSYMCRHGSTAEGP---------LGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPK 2052

Query: 1983 ----LAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPA 2038
                L     A +   +  L P G  RSP   R L RQ A+ TDSL+ +    R+ L   
Sbjct: 2053 DAPHLLQPHSAPTWGTIPKLPPPG--RSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLAE 2110

Query: 2039 EPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGE--------E 2090
              G   P  P+ +  S     +S   A   +R H+   + ++     PG E        E
Sbjct: 2111 VSG---PSPPLARAYSFWG--QSSTQAQQHSRSHSKISKHMTPPAPCPGPEPNWGKGPPE 2165

Query: 2091 AEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGR- 2149
              +S   D E+S I+    P      P G E  P     RDL++ YSV+AQ    +P   
Sbjct: 2166 TRSSLELDTELSWISGDLLP------PGGQEEPP---SPRDLKKCYSVEAQSCQRRPTSW 2216

Query: 2150 ADEQWRPSAELGSGEPGEAKAWGPE-----AEP--ALGARRKKKMSPPCISVEPPAEDEG 2202
             DEQ R S  +   + G     G +      +P    G+R KKK+SPP I+++PP E +G
Sbjct: 2217 LDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGPGSRPKKKLSPPSITIDPP-ESQG 2275

Query: 2203 SARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLT 2262
               P +       LRRR PS       DS +P     A G P +        S + + L+
Sbjct: 2276 PRTPPSP---GICLRRRAPS------SDSKDPL----ASGPPDSMA---ASPSPKKDVLS 2319

Query: 2263 VPSFAFEPLDL 2273
            +   + +P DL
Sbjct: 2320 LSGLSSDPADL 2330


>gi|38505294 voltage-dependent calcium channel alpha 1G subunit
            isoform 15 [Homo sapiens]
          Length = 1555

 Score = 1612 bits (4174), Expect = 0.0
 Identities = 897/1524 (58%), Positives = 1029/1524 (67%), Gaps = 114/1524 (7%)

Query: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66

Query: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186

Query: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246

Query: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305

Query: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358

Query: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418

Query: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478

Query: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536

Query: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592

Query: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642

Query: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696

Query: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740

Query: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800

Query: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860

Query: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919

Query: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE--------- 1021
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAE         
Sbjct: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979

Query: 1022 --------------GDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLE 1067
                          GDAN+S+++ D  S   + D  +         K C   V+   H E
Sbjct: 980  GQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDR---------KKCLALVSLGEHPE 1030

Query: 1068 GRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLR 1125
             R SL PPLI+ TAATPM  PKS+         P SRR SSS    P    + K P S R
Sbjct: 1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR 1090

Query: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAA 1185
            SSP +PW  + +W+SRRSS +SLGRAPSLKRR   GER SLLSGEG+ S D+E       
Sbjct: 1091 SSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEER 1150

Query: 1186 PGPRATPLRRAESLDPRPLRPAALPPT-----------------KCRDRDGQVVALPSDF 1228
              P  +  R   SL+        LP T                 + +D +G+  +     
Sbjct: 1151 ASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLAR 1210

Query: 1229 FLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQ 1288
             LR D    D  + DD+   S   R+   +    P  C  R++W+ Y+F PQ+RFR+ C 
Sbjct: 1211 ALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCH 1270

Query: 1289 KVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVV 1348
            ++ITHKMFDHVVLV IFLNC+TIA+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVV
Sbjct: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330

Query: 1349 ALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLR 1408
            ALG   GE AYL+SSWN+LDGLLVL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLR
Sbjct: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390

Query: 1409 VISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468
            VISRA GLKLVVETL+SSL+PIGNIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+
Sbjct: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450

Query: 1469 TKAQCRAAHYRWVRRKYNFDNLGQ 1492
             K+ C  A YRWVR KYNFDNLGQ
Sbjct: 1451 NKSDCAEASYRWVRHKYNFDNLGQ 1474



 Score =  122 bits (306), Expect = 4e-27
 Identities = 113/442 (25%), Positives = 199/442 (45%), Gaps = 44/442 (9%)

Query: 1583 RRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQP 1642
            RR+RS    P+A+     A +     +   +  S Y    I   I VN ++M +E++ QP
Sbjct: 711  RRQRSL--GPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQP 768

Query: 1643 KSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIE 1702
            + L  AL+  N VFT +F  E  LKL+ +G   + K+ +N  D  IV++S+  I  ++  
Sbjct: 769  EELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ-- 826

Query: 1703 MSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFI 1762
                       + ++R  R+ RVLKL++    ++  L  +++ +  V    +L ML  FI
Sbjct: 827  --------GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFI 878

Query: 1763 YAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECS 1822
            ++ LG+ LFG    SE +  + L     F +   A +T+F++ T ++WN ++ + +   S
Sbjct: 879  FSILGMHLFGCKFASERDG-DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTS 937

Query: 1823 REDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAE-IE 1881
                       + + +YF+  +    +VL N++VA+L++  +      REDA      I+
Sbjct: 938  -----------SWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQ 986

Query: 1882 LEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPAS 1941
            L +    G A + +++         G  D    +A       ++SL     + + ++P  
Sbjct: 987  LPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLA-------LVSLGEHPELRKSLLPPL 1039

Query: 1942 APH--PRPLQEVEMETYGAGTPLG--SVASVHSPPAESCASLQI---PLAVSSP-----A 1989
              H    P+   +  + G G  LG  S  +  S  AE  A+ ++   P A SSP     A
Sbjct: 1040 IIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSA 1099

Query: 1990 RSGEPLHALSPRGTARSPSLSR 2011
             S       S     R+PSL R
Sbjct: 1100 ASSWTSRRSSRNSLGRAPSLKR 1121



 Score =  114 bits (284), Expect = 1e-24
 Identities = 76/288 (26%), Positives = 148/288 (51%), Gaps = 47/288 (16%)

Query: 1288 QKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKV 1347
            +K++  K F   +++ I +N +++ +E  +     T    L +SN +FT++F  EM++K+
Sbjct: 737  RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA--LEISNIVFTSLFALEMLLKL 794

Query: 1348 VALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPL 1407
                L+ G   Y+++ +N+ DG++V++S+ +IV      GG   L VLR  RL+R L+ +
Sbjct: 795  ----LVYGPFGYIKNPYNIFDGVIVVISVWEIV---GQQGGG--LSVLRTFRLMRVLKLV 845

Query: 1408 RVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNI 1467
            R +   P L+  +  L+ ++  +    ++   F  IF ILG+ LF  KF      DT   
Sbjct: 846  RFL---PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT--- 899

Query: 1468 STKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNH 1527
                         +  + NFD+L  A++++F + +++ W  ++Y+G+ +           
Sbjct: 900  -------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST---------- 936

Query: 1528 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1575
            + W  LYFI+ +   ++ + N+ V ++VE F       +AEE  +RE+
Sbjct: 937  SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 64/211 (30%), Positives = 112/211 (53%), Gaps = 15/211 (7%)

Query: 1574 EEKRLRRLERRR---RSTFPSPEAQRRPYYADYSPTRRSIHSLC----TSHYLDLFITFI 1626
            +E  L + ER R   R+  P+   +R  + A   P +     LC    T    D  +  I
Sbjct: 1226 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1285

Query: 1627 ICVNVITMSMEHYN-QPKSLDEA-LKYCNYVFTIVFVFEAALKLVA----FGFRRFFKDR 1680
            I +N IT++ME     P S +   L   NY+FT VF+ E  +K+VA    FG + + +  
Sbjct: 1286 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1345

Query: 1681 WNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLD 1740
            WN LD  +VL+S++ I +  +  S    +   ++R++R+LR  R L+++  A G++ +++
Sbjct: 1346 WNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVLRLLRTLRPLRVISRAQGLKLVVE 1403

Query: 1741 TVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771
            T++ +L  +GN+ ++    F I+  LGV+LF
Sbjct: 1404 TLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 46/183 (25%), Positives = 87/183 (47%), Gaps = 23/183 (12%)

Query: 1602 DYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEAL-----KYCNYVF 1656
            D  P    + ++C   + +     +I +N +T+ M    +  + D         + +++F
Sbjct: 67   DSRPRSWCLRTVCNP-WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF 125

Query: 1657 TIVFVFEAALKLVA---FGFRRFFKDRWNQLDLAIVLLSLM--GITLEEIEMSAALPINP 1711
               F  E  +K+VA   FG + +  D WN+LD  IV+  ++   + L+ +  SA      
Sbjct: 126  AF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSA------ 178

Query: 1712 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771
                 +R +R+ R L+ +     MR L+  ++  LP +GN+ LL   +FFI+  +GV+L+
Sbjct: 179  -----VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233

Query: 1772 GRL 1774
              L
Sbjct: 234  AGL 236



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 33/109 (30%), Positives = 61/109 (55%), Gaps = 14/109 (12%)

Query: 1473 CRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWML 1532
            C A  +   +   NFDN+G A +++F + + +GWV+IMY  +DA          H+ +  
Sbjct: 323  CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNF 372

Query: 1533 LYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1581
            +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417



 Score = 38.5 bits (88), Expect = 0.079
 Identities = 23/100 (23%), Positives = 43/100 (43%), Gaps = 14/100 (14%)

Query: 1769 ELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHC 1828
            + +      E NP +G      F N G A++ +F+V T + W  IM   +      D H 
Sbjct: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM------DAHS 368

Query: 1829 LSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNK 1868
                     +YF+  ++V  F ++N+ + V+     E+ +
Sbjct: 369  FYNF-----IYFILLIIVGSFFMINLCLVVIATQFSETKQ 403


>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform b [Homo sapiens]
          Length = 2188

 Score = 1599 bits (4140), Expect = 0.0
 Identities = 921/1630 (56%), Positives = 1079/1630 (66%), Gaps = 147/1630 (9%)

Query: 649  LSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALE 708
            L   +P P +  PH          P H    + P  L  P   TL  +  SCP C     
Sbjct: 467  LGPEAPAPAKPGPHAKEPRHYQLCPQHSPLDATPHTLVQPIPATLASDPASCPCCQHEDG 526

Query: 709  DPEGELSGSESG-DSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRA 767
                 L  ++SG +  G G     +D   GD          +   G      +   ++  
Sbjct: 527  RRPSGLGSTDSGQEGSGSGSSAGGEDEADGDG-------ARSSEDGASSELGKEEEEEEQ 579

Query: 768  APGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEI 827
            A G     G +W     KLR IVDSKYF+RGIMMAILVNT+SMG+E+HEQPEELTN LEI
Sbjct: 580  ADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEI 639

Query: 828  SNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFR 887
             N+VFTSMFALEM+LKL A G   Y+RNPYNIFD IIV+IS+WEIVGQADGGLSVLRTFR
Sbjct: 640  CNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFR 699

Query: 888  LLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDT 947
            LLRVLKLVRF+PALRRQLVVL+KTMDNVATFC LLMLFIFIFSILGMH+FGCKFSL+TDT
Sbjct: 700  LLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDT 759

Query: 948  GDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLF 1007
            GDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTS WA+LYFVALMTFGNYVLF
Sbjct: 760  GDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLF 819

Query: 1008 NLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLREL--QTTELKMCSLAVTPNGH 1065
            NLLVAILVEGFQAEGDANRS +DED++S + EE F KL+E    + + K+C + +TPNGH
Sbjct: 820  NLLVAILVEGFQAEGDANRSYSDEDQSSSNIEE-FDKLQEGLDSSGDPKLCPIPMTPNGH 878

Query: 1066 LEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLR 1125
            L+    L   L    AA P P     P  D       SR+ S  S      DQ+  +S R
Sbjct: 879  LDPSLPLGGHLGPAGAAGPAPRLSLQP--DPMLVALGSRKSSVMSLGRMSYDQRSLSSSR 936

Query: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGST---DDEAEDG 1182
            SS   PWG S AW+SRRSSW+SL      K +    E ESLLS E  G     +  A++G
Sbjct: 937  SSYYGPWGRSAAWASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEG 990

Query: 1183 --RAAP-----------GP----RATPLRRAESLD-----------------PRPLRPAA 1208
              RAAP           GP    R    RR  SLD                 PR    AA
Sbjct: 991  PPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAA 1050

Query: 1209 LPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRS 1268
             P     D +G++ ++  D F ++   R D  E +++ + + C R+ K+++ YKP WC  
Sbjct: 1051 GPAPGHEDCNGRMPSIAKDVFTKMGD-RGDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEV 1109

Query: 1269 REAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFL 1328
            RE W++YLFSP+NRFRV CQ +I HK+FD+VVL FIFLNC+TIALERP I+ GSTER+FL
Sbjct: 1110 REDWSVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFL 1169

Query: 1329 SVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGG 1388
            +VSNYIFTAIFV EM +KVV+LGL  GE AYL+SSWN+LDG LV VS++DIVV++ASAGG
Sbjct: 1170 TVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGG 1229

Query: 1389 AKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILG 1448
            AKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSL+PIGNIVLICCAFFIIFGILG
Sbjct: 1230 AKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILG 1289

Query: 1449 VQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVN 1508
            VQLFKGKFY+C G DTRNI+ ++ C AA+YRWV  KYNFDNLGQALMSLFVL+SKDGWVN
Sbjct: 1290 VQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVN 1349

Query: 1509 IMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAE 1568
            IMY+GLDAV VDQQPV NHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAE
Sbjct: 1350 IMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAE 1409

Query: 1569 EARRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIIC 1628
            EARRREEKRLRRLE++RR      +AQR PYYA Y  TR  IHS+CTSHYLD+FITFIIC
Sbjct: 1410 EARRREEKRLRRLEKKRR------KAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIIC 1463

Query: 1629 VNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAI 1688
            +NV+TMS+EHYNQP SL+ ALKYCNY+FT VFV EA LKLVAFG RRFFKDRWNQLDLAI
Sbjct: 1464 LNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAI 1523

Query: 1689 VLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ 1748
            VLLS+MGITLEEIE++AALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ
Sbjct: 1524 VLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQ 1583

Query: 1749 VGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGD 1808
            VGNLGLLFMLLFFIYAALGVELFG+L C+++NPCEG+SRHATF NFGMAFLTLF+VSTGD
Sbjct: 1584 VGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1643

Query: 1809 NWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNK 1868
            NWNGIMKDTLR+C+ +++ CLS L  +SP+YFV+FVL AQFVL+NVVVAVLMKHL++SNK
Sbjct: 1644 NWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNK 1703

Query: 1869 EAREDAELDAEIELEMAQGPGSARRVDADRPPLPQESPGAR------------------- 1909
            EA+EDAE+DAE+ELEMA G G   R+    P  P   PG                     
Sbjct: 1704 EAQEDAEMDAELELEMAHGLGPGPRLPTGSPGAPGRGPGGAGGGGDTEGGLCRRCYSPAQ 1763

Query: 1910 -----DAPNLVARKVSVSRMLSLPNDS-----YMFRPVVPASAPHPR-PLQEVEMETYGA 1958
                 D+ +L+ +      +  + N S     +   P       H +  +Q  E E +  
Sbjct: 1764 ENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHHYSSPAGCKKCHHDKQEVQLAETEAFSL 1823

Query: 1959 GTP------LGSVASVHSPPA------ESCASLQIPLAVSSPARSGEPLHALSP-RGTAR 2005
             +       LG   S+  P A      +S   L  P     P R G+      P   TA 
Sbjct: 1824 NSDRSSSILLGDDLSLEDPTACPPGRKDSKGELDPP----EPMRVGDLGECFFPLSSTAV 1879

Query: 2006 SPSLSRLLCRQEAVHTDSLEG--KIDSPRDTLDPAEPGEKTPVRPV-------------- 2049
            SP     LC  E +  + +    K DS +    P  P   +P+ P+              
Sbjct: 1880 SPDPENFLCEMEEIPFNPVRSWLKHDSSQAPPSPFSPDASSPLLPMPAEFFHPAVSASQK 1939

Query: 2050 -----TQGGSLQ--------SPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDP 2096
                 T  G+L         +  RSPR      R+ T     + + P++  G      + 
Sbjct: 1940 GPEKGTGTGTLPKIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLED 1999

Query: 2097 ADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRP 2156
            +      +T S  P +    P  P   P AG     RR  S+  +G     G    Q R 
Sbjct: 2000 S------LTLSDSPRRALGPP-APAPGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQ-RS 2051

Query: 2157 SAELGSGEPG 2166
             +  GS  PG
Sbjct: 2052 HSSGGSTSPG 2061



 Score =  624 bits (1608), Expect = e-178
 Identities = 318/492 (64%), Positives = 370/492 (75%), Gaps = 6/492 (1%)

Query: 28  ASPESPGAPGREAERG-SELGVSPSESPAAERGAELGAD-EEQRVPYPALAATVFFCLGQ 85
           ASP S  A    AE G +     P   P++  G E   D  +  VP+P LA   FFCL Q
Sbjct: 5   ASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQ 64

Query: 86  TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
           TT PR+WC+++VCNPWFE VSMLVI+LNCVTLGM++PC+D++C S+RC IL+ FD FIF 
Sbjct: 65  TTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI 124

Query: 146 FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
           FFA+EMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  N++LSAIRTVRVLR
Sbjct: 125 FFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLR 184

Query: 206 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
           PL+AINRVPSMRILV LLLDTLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL+  
Sbjct: 185 PLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEEN 244

Query: 266 FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGW-EAYTQ 324
           F    ++  L PYYQ EE +E PFICS   DNG+  C  IP  +E    C L   + Y  
Sbjct: 245 FTIQGDVA-LPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDF 303

Query: 325 PQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIM 384
                   A   C+NWN+YYNVCR+G +NPH GAINFDNIGYAWI IFQVITLEGWV+IM
Sbjct: 304 GAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIM 363

Query: 385 YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLSND 444
           YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS+ 
Sbjct: 364 YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSS- 422

Query: 445 STLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQ 504
           ST+AS++EPG CYEE+ +YV HI RK KRR+L LY   QSR R+ + P A     PG   
Sbjct: 423 STVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSR-RQALGPEAPAPAKPGPHA 481

Query: 505 RRAGRHTASVHH 516
           +    +     H
Sbjct: 482 KEPRHYQLCPQH 493



 Score =  116 bits (290), Expect = 3e-25
 Identities = 67/192 (34%), Positives = 109/192 (56%), Gaps = 10/192 (5%)

Query: 88   RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFF 147
            R R  C  ++ +  F++V +  I LNC+T+ + RP   +E GS     L   +    A F
Sbjct: 1123 RFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTERIFLTVSNYIFTAIF 1180

Query: 148  AVEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEY-----SLDGHNVS--LSAIR 199
              EM +K+V+LGL FG++ YL  +WN LD F+V   +++      S  G  +   L  +R
Sbjct: 1181 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1240

Query: 200  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 259
             +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL+ G   + 
Sbjct: 1241 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1300

Query: 260  CFLDSAFVRNNN 271
              +D+  + N +
Sbjct: 1301 LGVDTRNITNRS 1312



 Score =  109 bits (272), Expect = 4e-23
 Identities = 60/170 (35%), Positives = 100/170 (58%), Gaps = 10/170 (5%)

Query: 1287 CQKVITHKMFDHVVLVFIFLNCVTIALERP--DIDPGSTERVFLSVSNYIFTAIFVAEMM 1344
            C K++ +  F+ V ++ I LNCVT+ + +P  D+D  S     L V +      F  EM+
Sbjct: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMV 131

Query: 1345 VKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTL 1404
            +K+VALG+  G+  YL  +WN LD  +V+  +V+  + + +         L  +R +R L
Sbjct: 132  LKMVALGIF-GKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRVL 183

Query: 1405 RPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKG 1454
            RPL+ I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL+ G
Sbjct: 184  RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233



 Score = 85.1 bits (209), Expect = 7e-16
 Identities = 68/252 (26%), Positives = 115/252 (45%), Gaps = 29/252 (11%)

Query: 3   EGARAADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGAEL 62
           +G R +       G    G  +  G   E+ G   R +E G+               +EL
Sbjct: 525 DGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGAS--------------SEL 570

Query: 63  GADEEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRP 122
           G +EE+          V+ C       R+    +V + +F    M+ I++N V++G+   
Sbjct: 571 GKEEEEE---EQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI--- 624

Query: 123 CEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAG 182
            E  E   E  NILE  +    + FA+EM++K+ A GLF    YL + +N  D  IV+  
Sbjct: 625 -EHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFD---YLRNPYNIFDSIIVIIS 680

Query: 183 MMEY--SLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 240
           + E     DG    LS +RT R+LR L+ +  +P++R  + +L+ T+  +    +L    
Sbjct: 681 IWEIVGQADG---GLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLF 737

Query: 241 FFIFGIVGVQLW 252
            FIF I+G+ ++
Sbjct: 738 IFIFSILGMHIF 749



 Score = 71.6 bits (174), Expect = 8e-12
 Identities = 53/183 (28%), Positives = 89/183 (48%), Gaps = 27/183 (14%)

Query: 1604 SPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYC-------NYVF 1656
            SP    I  +C   + +     +I +N +T+ M  Y     +D     C       +++F
Sbjct: 67   SPRNWCIKMVCNP-WFECVSMLVILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIF 123

Query: 1657 TIVFVFEAALKLVA---FGFRRFFKDRWNQLDLAIVLLSLM--GITLEEIEMSAALPINP 1711
             I F  E  LK+VA   FG + +  D WN+LD  IV+  ++   + L+ I +SA      
Sbjct: 124  -IFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA------ 176

Query: 1712 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771
                 +R +R+ R LK +     MR L++ ++  LP +GN+ LL   +FFI+  +GV+L+
Sbjct: 177  -----IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231

Query: 1772 GRL 1774
              L
Sbjct: 232  AGL 234



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 46/161 (28%), Positives = 82/161 (50%), Gaps = 20/161 (12%)

Query: 109  VIMLNCVTLGM--FRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCY 166
            +I LN VT+ +  +     +E   + CN +          F +E V+K+VA GL   + +
Sbjct: 1461 IICLNVVTMSLEHYNQPTSLETALKYCNYM------FTTVFVLEAVLKLVAFGL---RRF 1511

Query: 167  LGDTWNRLDFFIVVAGMMEYSLDGHNVS---------LSAIRTVRVLRPLRAINRVPSMR 217
              D WN+LD  IV+  +M  +L+   ++         +  +R +R+ R L+ +     MR
Sbjct: 1512 FKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMR 1571

Query: 218  ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258
             L+  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 1572 ALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 45/161 (27%), Positives = 84/161 (52%), Gaps = 14/161 (8%)

Query: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQP-------EELTNALEISNIVFTSMFALEM 840
           ++V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130

Query: 841 LLKLLACGPLG---YIRNPYNIFDGIIVVISVWEI-VGQADGGLSVLRTFRLLRVLKLVR 896
           +LK++A G  G   Y+ + +N  D  IV+  + E  +   +  LS +RT R+LR LK + 
Sbjct: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190

Query: 897 FLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 937
            +P++R  + +L+ T+  +     L     FIF I+G+ L+
Sbjct: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231



 Score = 58.9 bits (141), Expect = 6e-08
 Identities = 31/96 (32%), Positives = 56/96 (58%), Gaps = 14/96 (14%)

Query: 360  NFDNIGYAWIAIFQVITLEGWVDIMYYVMDA----------HSFYNFIYFILLIIVGSFF 409
            NFDN+G A +++F + + +GWV+IMY  +DA          H+ +  +YFI  +++ SFF
Sbjct: 1327 NFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFF 1386

Query: 410  MINLCLVVIATQFSETKQ----RESQLMREQRARHL 441
            ++N+ + V+   F + +Q     E++   E+R R L
Sbjct: 1387 VLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 35/120 (29%), Positives = 60/120 (50%), Gaps = 14/120 (11%)

Query: 1473 CRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWML 1532
            CR       +   NFDN+G A + +F + + +GWV IMY  +DA          H+ +  
Sbjct: 326  CRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNF 375

Query: 1533 LYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPSP 1592
            +YFI  +++ SFF++N+ + V+   F + +Q     E R   E+R R L     +++  P
Sbjct: 376  IYFILLIIVGSFFMINLCLVVIATQFSETKQ----REHRLMLEQRQRYLSSSTVASYAEP 431



 Score = 48.5 bits (114), Expect = 8e-05
 Identities = 22/74 (29%), Positives = 43/74 (58%), Gaps = 2/74 (2%)

Query: 947  TGDTVPDRK--NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNY 1004
            TG   P +   NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++
Sbjct: 328  TGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSF 387

Query: 1005 VLFNLLVAILVEGF 1018
             + NL + ++   F
Sbjct: 388  FMINLCLVVIATQF 401



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 2/74 (2%)

Query: 349 SGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSF 408
           +GD+ P     NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++
Sbjct: 759 TGDTVPDRK--NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNY 816

Query: 409 FMINLCLVVIATQF 422
            + NL + ++   F
Sbjct: 817 VLFNLLVAILVEGF 830



 Score = 38.9 bits (89), Expect = 0.060
 Identities = 22/95 (23%), Positives = 42/95 (44%), Gaps = 14/95 (14%)

Query: 351  DSNPHNGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YYVMDAHSFYNF 396
            D NP  G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672

Query: 397  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 431
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707



 Score = 35.8 bits (81), Expect = 0.51
 Identities = 22/89 (24%), Positives = 40/89 (44%), Gaps = 14/89 (15%)

Query: 1780 NPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVY 1839
            NP +G      F N G A++ +F+V T + W  IM   +      D H          +Y
Sbjct: 332  NPHKGA---INFDNIGYAWIVIFQVITLEGWVEIMYYVM------DAHSFYNF-----IY 377

Query: 1840 FVTFVLVAQFVLVNVVVAVLMKHLEESNK 1868
            F+  ++V  F ++N+ + V+     E+ +
Sbjct: 378  FILLIIVGSFFMINLCLVVIATQFSETKQ 406


>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform a [Homo sapiens]
          Length = 2223

 Score = 1595 bits (4131), Expect = 0.0
 Identities = 927/1657 (55%), Positives = 1086/1657 (65%), Gaps = 161/1657 (9%)

Query: 622  GSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSV 681
            G  KG    G +G+  G       HGP S  +              G    P H    + 
Sbjct: 489  GKTKGQ---GDEGRHLGSRHCQTLHGPASPGND-----------HSGRELCPQHSPLDAT 534

Query: 682  PCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESG-DSDGRGVYEFTQDVRHGDRW 740
            P  L  P   TL  +  SCP C          L  ++SG +  G G     +D   GD  
Sbjct: 535  PHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDG- 593

Query: 741  DPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIM 800
                    +   G      +   ++  A G     G +W     KLR IVDSKYF+RGIM
Sbjct: 594  ------ARSSEDGASSELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIM 647

Query: 801  MAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIF 860
            MAILVNT+SMG+E+HEQPEELTN LEI N+VFTSMFALEM+LKL A G   Y+RNPYNIF
Sbjct: 648  MAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIF 707

Query: 861  DGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCT 920
            D IIV+IS+WEIVGQADGGLSVLRTFRLLRVLKLVRF+PALRRQLVVL+KTMDNVATFC 
Sbjct: 708  DSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCM 767

Query: 921  LLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL 980
            LLMLFIFIFSILGMH+FGCKFSL+TDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL
Sbjct: 768  LLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL 827

Query: 981  YNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEE 1040
            YNGMASTS WA+LYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRS +DED++S + EE
Sbjct: 828  YNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEE 887

Query: 1041 DFHKLREL--QTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAP 1098
             F KL+E    + + K+C + +TPNGHL+    L   L    AA P P     P  D   
Sbjct: 888  -FDKLQEGLDSSGDPKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQP--DPML 944

Query: 1099 SLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRG 1158
                SR+ S  S      DQ+  +S RSS   PWG S AW+SRRSSW+SL      K + 
Sbjct: 945  VALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAAWASRRSSWNSL------KHKP 998

Query: 1159 QCGERESLLSGEGKGST---DDEAEDG--RAAP-----------GP----RATPLRRAES 1198
               E ESLLS E  G     +  A++G  RAAP           GP    R    RR  S
Sbjct: 999  PSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIHHGPHLAHRHRHHRRTLS 1058

Query: 1199 LD-----------------PRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAE 1241
            LD                 PR    AA P     D +G++ ++  D F ++   R D  E
Sbjct: 1059 LDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVFTKMGD-RGDRGE 1117

Query: 1242 LDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVL 1301
             +++ + + C R+ K+++ YKP WC  RE W++YLFSP+NRFRV CQ +I HK+FD+VVL
Sbjct: 1118 DEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKLFDYVVL 1177

Query: 1302 VFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQ 1361
             FIFLNC+TIALERP I+ GSTER+FL+VSNYIFTAIFV EM +KVV+LGL  GE AYL+
Sbjct: 1178 AFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLR 1237

Query: 1362 SSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVE 1421
            SSWN+LDG LV VS++DIVV++ASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVE
Sbjct: 1238 SSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVE 1297

Query: 1422 TLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWV 1481
            TLISSL+PIGNIVLICCAFFIIFGILGVQLFKGKFY+C G DTRNI+ ++ C AA+YRWV
Sbjct: 1298 TLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWV 1357

Query: 1482 RRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLI 1541
              KYNFDNLGQALMSLFVL+SKDGWVNIMY+GLDAV VDQQPV NHNPWMLLYFISFLLI
Sbjct: 1358 HHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLI 1417

Query: 1542 VSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPSPEAQRRPYYA 1601
            VSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLE++RR      +AQR PYYA
Sbjct: 1418 VSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR------KAQRLPYYA 1471

Query: 1602 DYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFV 1661
             Y  TR  IHS+CTSHYLD+FITFIIC+NV+TMS+EHYNQP SL+ ALKYCNY+FT VFV
Sbjct: 1472 TYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFV 1531

Query: 1662 FEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLR 1721
             EA LKLVAFG RRFFKDRWNQLDLAIVLLS+MGITLEEIE++AALPINPTIIRIMRVLR
Sbjct: 1532 LEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLR 1591

Query: 1722 IARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNP 1781
            IARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFG+L C+++NP
Sbjct: 1592 IARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENP 1651

Query: 1782 CEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFV 1841
            CEG+SRHATF NFGMAFLTLF+VSTGDNWNGIMKDTLR+C+ +++ CLS L  +SP+YFV
Sbjct: 1652 CEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFV 1711

Query: 1842 TFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQGPGSARRVDADRPPL 1901
            +FVL AQFVL+NVVVAVLMKHL++SNKEA+EDAE+DAE+ELEMA G G   R+    P  
Sbjct: 1712 SFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRLPTGSPGA 1771

Query: 1902 PQESPGAR------------------------DAPNLVARKVSVSRMLSLPNDS-----Y 1932
            P   PG                          D+ +L+ +      +  + N S     +
Sbjct: 1772 PGRGPGGAGGGGDTEGGLCRRCYSPAQENLWLDSVSLIIKDSLEGELTIIDNLSGSIFHH 1831

Query: 1933 MFRPVVPASAPHPR-PLQEVEMETYGAGTP------LGSVASVHSPPA------ESCASL 1979
               P       H +  +Q  E E +   +       LG   S+  P A      +S   L
Sbjct: 1832 YSSPAGCKKCHHDKQEVQLAETEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGEL 1891

Query: 1980 QIPLAVSSPARSGEPLHALSP-RGTARSPSLSRLLCRQEAVHTDSLEG--KIDSPRDTLD 2036
              P     P R G+      P   TA SP     LC  E +  + +    K DS +    
Sbjct: 1892 DPP----EPMRVGDLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVRSWLKHDSSQAPPS 1947

Query: 2037 PAEPGEKTPVRPV-------------------TQGGSLQ--------SPPRSPRPASVRT 2069
            P  P   +P+ P+                   T  G+L         +  RSPR      
Sbjct: 1948 PFSPDASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLPKIALQGSWASLRSPRVNCTLL 2007

Query: 2070 RKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGE 2129
            R+ T     + + P++  G      + +      +T S  P +    P  P   P AG  
Sbjct: 2008 RQATGSDTSLDASPSSSAGSLQTTLEDS------LTLSDSPRRALGPP-APAPGPRAGLS 2060

Query: 2130 RDLRRLYSVDAQGFLDKPGRADEQWRPSAELGSGEPG 2166
               RR  S+  +G     G    Q R  +  GS  PG
Sbjct: 2061 PAARRRLSLRGRGLFSLRGLRAHQ-RSHSSGGSTSPG 2096



 Score =  626 bits (1614), Expect = e-179
 Identities = 324/516 (62%), Positives = 376/516 (72%), Gaps = 7/516 (1%)

Query: 28  ASPESPGAPGREAERG-SELGVSPSESPAAERGAELGAD-EEQRVPYPALAATVFFCLGQ 85
           ASP S  A    AE G +     P   P++  G E   D  +  VP+P LA   FFCL Q
Sbjct: 5   ASPPSSSAAAPAAEPGVTTEQPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQ 64

Query: 86  TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145
           TT PR+WC+++VCNPWFE VSMLVI+LNCVTLGM++PC+D++C S+RC IL+ FD FIF 
Sbjct: 65  TTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI 124

Query: 146 FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205
           FFA+EMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  N++LSAIRTVRVLR
Sbjct: 125 FFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLR 184

Query: 206 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265
           PL+AINRVPSMRILV LLLDTLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL+  
Sbjct: 185 PLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEEN 244

Query: 266 FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGW-EAYTQ 324
           F    ++  L PYYQ EE +E PFICS   DNG+  C  IP  +E    C L   + Y  
Sbjct: 245 FTIQGDVA-LPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYDF 303

Query: 325 PQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIM 384
                   A   C+NWN+YYNVCR+G +NPH GAINFDNIGYAWI IFQVITLEGWV+IM
Sbjct: 304 GAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIM 363

Query: 385 YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLSND 444
           YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS+ 
Sbjct: 364 YYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSS- 422

Query: 445 STLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHRQ 504
           ST+AS++EPG CYEE+ +YV HI RK KRR+L LY   QSR R+ + P A     PG   
Sbjct: 423 STVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSR-RQALGPEAPAPAKPGPHA 481

Query: 505 RRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPG 540
           +    +            H    H    HG P  PG
Sbjct: 482 KEPRHYHGKTKGQGDEGRHLGSRHCQTLHG-PASPG 516



 Score =  116 bits (290), Expect = 3e-25
 Identities = 67/192 (34%), Positives = 109/192 (56%), Gaps = 10/192 (5%)

Query: 88   RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFF 147
            R R  C  ++ +  F++V +  I LNC+T+ + RP   +E GS     L   +    A F
Sbjct: 1158 RFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTERIFLTVSNYIFTAIF 1215

Query: 148  AVEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEY-----SLDGHNVS--LSAIR 199
              EM +K+V+LGL FG++ YL  +WN LD F+V   +++      S  G  +   L  +R
Sbjct: 1216 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1275

Query: 200  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 259
             +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL+ G   + 
Sbjct: 1276 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1335

Query: 260  CFLDSAFVRNNN 271
              +D+  + N +
Sbjct: 1336 LGVDTRNITNRS 1347



 Score =  109 bits (272), Expect = 4e-23
 Identities = 60/170 (35%), Positives = 100/170 (58%), Gaps = 10/170 (5%)

Query: 1287 CQKVITHKMFDHVVLVFIFLNCVTIALERP--DIDPGSTERVFLSVSNYIFTAIFVAEMM 1344
            C K++ +  F+ V ++ I LNCVT+ + +P  D+D  S     L V +      F  EM+
Sbjct: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMV 131

Query: 1345 VKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTL 1404
            +K+VALG+  G+  YL  +WN LD  +V+  +V+  + + +         L  +R +R L
Sbjct: 132  LKMVALGIF-GKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRVL 183

Query: 1405 RPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKG 1454
            RPL+ I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL+ G
Sbjct: 184  RPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233



 Score = 85.1 bits (209), Expect = 7e-16
 Identities = 68/252 (26%), Positives = 115/252 (45%), Gaps = 29/252 (11%)

Query: 3   EGARAADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGAEL 62
           +G R +       G    G  +  G   E+ G   R +E G+               +EL
Sbjct: 560 DGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGAS--------------SEL 605

Query: 63  GADEEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRP 122
           G +EE+          V+ C       R+    +V + +F    M+ I++N V++G+   
Sbjct: 606 GKEEEEE---EQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI--- 659

Query: 123 CEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAG 182
            E  E   E  NILE  +    + FA+EM++K+ A GLF    YL + +N  D  IV+  
Sbjct: 660 -EHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFD---YLRNPYNIFDSIIVIIS 715

Query: 183 MMEY--SLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFV 240
           + E     DG    LS +RT R+LR L+ +  +P++R  + +L+ T+  +    +L    
Sbjct: 716 IWEIVGQADG---GLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLF 772

Query: 241 FFIFGIVGVQLW 252
            FIF I+G+ ++
Sbjct: 773 IFIFSILGMHIF 784



 Score = 71.6 bits (174), Expect = 8e-12
 Identities = 53/183 (28%), Positives = 89/183 (48%), Gaps = 27/183 (14%)

Query: 1604 SPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYC-------NYVF 1656
            SP    I  +C   + +     +I +N +T+ M  Y     +D     C       +++F
Sbjct: 67   SPRNWCIKMVCNP-WFECVSMLVILLNCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIF 123

Query: 1657 TIVFVFEAALKLVA---FGFRRFFKDRWNQLDLAIVLLSLM--GITLEEIEMSAALPINP 1711
             I F  E  LK+VA   FG + +  D WN+LD  IV+  ++   + L+ I +SA      
Sbjct: 124  -IFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA------ 176

Query: 1712 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771
                 +R +R+ R LK +     MR L++ ++  LP +GN+ LL   +FFI+  +GV+L+
Sbjct: 177  -----IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231

Query: 1772 GRL 1774
              L
Sbjct: 232  AGL 234



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 46/161 (28%), Positives = 82/161 (50%), Gaps = 20/161 (12%)

Query: 109  VIMLNCVTLGM--FRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLFGQKCY 166
            +I LN VT+ +  +     +E   + CN +          F +E V+K+VA GL   + +
Sbjct: 1496 IICLNVVTMSLEHYNQPTSLETALKYCNYM------FTTVFVLEAVLKLVAFGL---RRF 1546

Query: 167  LGDTWNRLDFFIVVAGMMEYSLDGHNVS---------LSAIRTVRVLRPLRAINRVPSMR 217
              D WN+LD  IV+  +M  +L+   ++         +  +R +R+ R L+ +     MR
Sbjct: 1547 FKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMR 1606

Query: 218  ILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258
             L+  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 1607 ALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 45/161 (27%), Positives = 84/161 (52%), Gaps = 14/161 (8%)

Query: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQP-------EELTNALEISNIVFTSMFALEM 840
           ++V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130

Query: 841 LLKLLACGPLG---YIRNPYNIFDGIIVVISVWEI-VGQADGGLSVLRTFRLLRVLKLVR 896
           +LK++A G  G   Y+ + +N  D  IV+  + E  +   +  LS +RT R+LR LK + 
Sbjct: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190

Query: 897 FLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 937
            +P++R  + +L+ T+  +     L     FIF I+G+ L+
Sbjct: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231



 Score = 58.9 bits (141), Expect = 6e-08
 Identities = 31/96 (32%), Positives = 56/96 (58%), Gaps = 14/96 (14%)

Query: 360  NFDNIGYAWIAIFQVITLEGWVDIMYYVMDA----------HSFYNFIYFILLIIVGSFF 409
            NFDN+G A +++F + + +GWV+IMY  +DA          H+ +  +YFI  +++ SFF
Sbjct: 1362 NFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFF 1421

Query: 410  MINLCLVVIATQFSETKQ----RESQLMREQRARHL 441
            ++N+ + V+   F + +Q     E++   E+R R L
Sbjct: 1422 VLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 35/120 (29%), Positives = 60/120 (50%), Gaps = 14/120 (11%)

Query: 1473 CRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWML 1532
            CR       +   NFDN+G A + +F + + +GWV IMY  +DA          H+ +  
Sbjct: 326  CRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA----------HSFYNF 375

Query: 1533 LYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFPSP 1592
            +YFI  +++ SFF++N+ + V+   F + +Q     E R   E+R R L     +++  P
Sbjct: 376  IYFILLIIVGSFFMINLCLVVIATQFSETKQ----REHRLMLEQRQRYLSSSTVASYAEP 431



 Score = 48.5 bits (114), Expect = 8e-05
 Identities = 22/74 (29%), Positives = 43/74 (58%), Gaps = 2/74 (2%)

Query: 947  TGDTVPDRK--NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNY 1004
            TG   P +   NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++
Sbjct: 328  TGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSF 387

Query: 1005 VLFNLLVAILVEGF 1018
             + NL + ++   F
Sbjct: 388  FMINLCLVVIATQF 401



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 2/74 (2%)

Query: 349 SGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSF 408
           +GD+ P     NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++
Sbjct: 794 TGDTVPDRK--NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNY 851

Query: 409 FMINLCLVVIATQF 422
            + NL + ++   F
Sbjct: 852 VLFNLLVAILVEGF 865



 Score = 38.9 bits (89), Expect = 0.060
 Identities = 22/95 (23%), Positives = 42/95 (44%), Gaps = 14/95 (14%)

Query: 351  DSNPHNGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YYVMDAHSFYNF 396
            D NP  G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707

Query: 397  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 431
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742



 Score = 35.8 bits (81), Expect = 0.51
 Identities = 22/89 (24%), Positives = 40/89 (44%), Gaps = 14/89 (15%)

Query: 1780 NPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVY 1839
            NP +G      F N G A++ +F+V T + W  IM   +      D H          +Y
Sbjct: 332  NPHKGA---INFDNIGYAWIVIFQVITLEGWVEIMYYVM------DAHSFYNF-----IY 377

Query: 1840 FVTFVLVAQFVLVNVVVAVLMKHLEESNK 1868
            F+  ++V  F ++N+ + V+     E+ +
Sbjct: 378  FILLIIVGSFFMINLCLVVIATQFSETKQ 406


>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
            sapiens]
          Length = 2016

 Score =  446 bits (1147), Expect = e-124
 Identities = 319/1162 (27%), Positives = 554/1162 (47%), Gaps = 136/1162 (11%)

Query: 778  LWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFA 837
            LW++    ++ +V   +    I M I++NTL M +E++    E    L++ N+VFT +F 
Sbjct: 702  LWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFT 761

Query: 838  LEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRF 897
             EM  K++A  P  Y +  +NIFD IIV++S+ E+       LSVLR+FRLLRV KL + 
Sbjct: 762  AEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 898  LPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNF 957
             P L   + ++  ++  +     +L + +FIF+++GM LFG  +S   D+   +  R + 
Sbjct: 822  WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHM 881

Query: 958  DSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAILVE 1016
                 A + +F+IL  E W   +++ M  S  S   L F+ +M  GN V+ NL +A+L+ 
Sbjct: 882  MDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLS 940

Query: 1017 GFQAEGDANRSDTDEDKTSVHFEEDFHK----LRELQTTELKMCS--LAVTPN--GHLEG 1068
             F A+   N +  DED+   + +    +    LR ++ T    C   L   P     L  
Sbjct: 941  SFSAD---NLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA 997

Query: 1069 RGSLSPPLIMCTAATPMP--TPKSSPFLDAAPSLPDSRRGSSSSGDPP------------ 1114
            +G L  P  + T  +P P  T K  P           + G  + GDP             
Sbjct: 998  QGQL--PSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESD 1055

Query: 1115 -----------LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGER 1163
                       LG ++  +  + S     GP     SR  +WS +    S +        
Sbjct: 1056 TDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSR--TWSQVSATASSE-------- 1105

Query: 1164 ESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVA 1223
                  E   S  D  +  +A               +P+       P   C +     + 
Sbjct: 1106 -----AEASASQADWRQQWKA---------------EPQAPGCGETPEDSCSEGSTADMT 1145

Query: 1224 LPSDFFLRIDSHREDAAELDDDSEDSC-----CLRLHKVLEPYKPQWCRSREAWALYLFS 1278
              ++   +I    +D  + +D   + C     C  +     P K  W             
Sbjct: 1146 NTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWW------------- 1192

Query: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338
               R R +C  ++ H  F+  ++  I L+   +A E   ++   T +V L  ++ +FT +
Sbjct: 1193 ---RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYV 1249

Query: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398
            FV EM++K VA G       Y  ++W  LD L+V VSLV +V   A+  G   +G ++ L
Sbjct: 1250 FVLEMLLKWVAYGFKK----YFTNAWCWLDFLIVDVSLVSLV---ANTLGFAEMGPIKSL 1302

Query: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458
            R LR LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKF  
Sbjct: 1303 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1362

Query: 1459 C----EGPDTRN---ISTKAQCRAAHYR----WVRRKYNFDNLGQALMSLFVLSSKDGWV 1507
            C    EG    N   ++ K+QC + +      W + K NFDN+G   ++L  +++  GW+
Sbjct: 1363 CINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWM 1422

Query: 1508 NIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEA 1567
            +IMY  +D+ G ++QP   +N +M +YF+ F++  SFF LN+F+GV+++NF++ ++    
Sbjct: 1423 DIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG 1482

Query: 1568 EEA-RRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFI 1626
            ++     E+K+     ++  S  P     ++P     +  +  I  + T    D+ I F+
Sbjct: 1483 QDIFMTEEQKKYYNAMKKLGSKKP-----QKPIPRPLNKYQGFIFDIVTKQAFDVTIMFL 1537

Query: 1627 ICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDL 1686
            IC+N++TM +E  +Q       L   N +F  +F  E  +KL A     +F + WN  D 
Sbjct: 1538 ICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDF 1596

Query: 1687 AIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQAL 1746
             +V+LS++G  L +I        +PT+ R++R+ RI R+L+L++ A G+R LL  ++ +L
Sbjct: 1597 VVVILSIVGTVLSDIIQKYF--FSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1654

Query: 1747 PQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVST 1806
            P + N+GLL  L+ FIY+  G+  F  ++        G+     F  F  + L LF+++T
Sbjct: 1655 PALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITT 1709

Query: 1807 GDNWNGIMK-----------DTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVV 1855
               W+G++             TL   +     C S  PA+  ++F T+++++  ++VN+ 
Sbjct: 1710 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGS--PAVGILFFTTYIIISFLIVVNMY 1767

Query: 1856 VAVLMKHLEESNKEAREDAELD 1877
            +A+++++   + +E+ E    D
Sbjct: 1768 IAIILENFSVATEESTEPLSED 1789



 Score =  142 bits (357), Expect = 5e-33
 Identities = 201/889 (22%), Positives = 352/889 (39%), Gaps = 190/889 (21%)

Query: 788  RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847
            +I+    F+  IM  IL N + M       P   T  +E +   FT+++  E L+K+LA 
Sbjct: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179

Query: 848  G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902
            G       ++R+P+N  D  +I++    E V    G +S LRTFR+LR LK +  +  L+
Sbjct: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237

Query: 903  RQLVVLVKTMDNVA------TFCTLLMLFIFIFSILGMHLFGC----------------- 939
              +  L++++  +A       FC  +   I +   +G     C                 
Sbjct: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297

Query: 940  ---------------KFSLKTDTGDTV-----------------------PDR--KNFDS 959
                            + LK  T D +                       PD    +FDS
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357

Query: 960  LLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019
              WA + +F+++TQ+ W  +    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417

Query: 1020 AEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMC 1079
             +  A  ++T+E       E+ F +  E+    LK    A+T    + G  ++S   +  
Sbjct: 418  EQNQATIAETEEK------EKRFQEAMEM----LKKEHEALT----IRGVDTVSRSSLEM 463

Query: 1080 TAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLG-DQKPPASLRSSPCAPWGPSGAW 1138
            +   P+ + +              RR   SSG    G D+ P +     P A    S   
Sbjct: 464  SPLAPVNSHERR----------SKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTR 513

Query: 1139 SSRRSSW---SSLGRAPSLKRRGQCGER-----ESLLSGEGKG--------------STD 1176
               R+S    SS G   + +RR    E      E+  +GE +               S  
Sbjct: 514  GLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQ 573

Query: 1177 DEAEDGRAAPGPRATPLRRA----------------ESLDPRP--LRPAAL--PP--TKC 1214
             +   G +APG      + +                E+  P    LRP  L  PP  T  
Sbjct: 574  GQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTP 633

Query: 1215 RDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYK----PQWCRSRE 1270
             +  G    L S     +D   E  A     S  S      + LE  +    P W R  +
Sbjct: 634  SEEPGGPQMLTSQAPC-VDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ 692

Query: 1271 AWALYLFSPQ-NRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLS 1329
             + ++   P     +   + V+     D  + + I LN + +ALE  ++     E   L 
Sbjct: 693  RYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQ 750

Query: 1330 VSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGA 1389
            V N +FT IF AEM  K++AL      + Y Q  WN+ D ++V++SL+++        G 
Sbjct: 751  VGNLVFTGIFTAEMTFKIIALD----PYYYFQQGWNIFDSIIVILSLMEL--------GL 798

Query: 1390 KILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGV 1449
              +  L VLR  R LR  ++    P L  +++ + +S+  +GN+ L+      IF ++G+
Sbjct: 799  SRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 858

Query: 1450 QLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNI 1509
            QLF GK Y             ++ R +    + R +  D     L+   +L  +  W+  
Sbjct: 859  QLF-GKNY-------------SELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE--WIET 902

Query: 1510 MYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558
            M+D ++  G             LL F+  ++I +  VLN+F+ +++ +F
Sbjct: 903  MWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942



 Score =  112 bits (281), Expect = 3e-24
 Identities = 73/269 (27%), Positives = 132/269 (49%), Gaps = 21/269 (7%)

Query: 1618 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1677
            + DL IT  I +N + M++EHYN     +E L+  N VFT +F  E   K++A     +F
Sbjct: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777

Query: 1678 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1737
            +  WN  D  IV+LSLM + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827

Query: 1738 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMA 1797
            L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      +   GL       +F  A
Sbjct: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887

Query: 1798 FLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVA 1857
            FL +FR+  G+ W   M D +    +          +L  + F+  +++   V++N+ +A
Sbjct: 888  FLIIFRILCGE-WIETMWDCMEVSGQ----------SLCLLVFLLVMVIGNLVVLNLFLA 936

Query: 1858 VLMKHLEESNKEAREDAELDAEIELEMAQ 1886
            +L+      N  A ++      ++L +A+
Sbjct: 937  LLLSSFSADNLTAPDEDREMNNLQLALAR 965



 Score =  109 bits (273), Expect = 3e-23
 Identities = 89/356 (25%), Positives = 168/356 (47%), Gaps = 49/356 (13%)

Query: 90  RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIF-AFFA 148
           R   ++++ +  F  + M  I+ NCV +    P    +           +  + F A + 
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK-----------YVEYTFTAIYT 169

Query: 149 VEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPL 207
            E ++K++A G       +L D WN LDF +++       +D  NVS  A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227

Query: 208 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFV 267
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C       
Sbjct: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV------ 281

Query: 268 RNNNLTFLRPYYQTEEGE----ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYT 323
              N T L     + E +    E+  +  S  +N + K     G  ++ + C    +A T
Sbjct: 282 --RNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLK----NGTSDVLL-CGNSSDAGT 334

Query: 324 QPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDI 383
            P+                 Y   ++G+ NP +G  +FD+  +A++A+F+++T + W  +
Sbjct: 335 CPEG----------------YRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERL 377

Query: 384 MYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRAR 439
               + +      I+F+L+I +GSF+++NL L V+A  + E  Q       E+  R
Sbjct: 378 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKR 433



 Score =  103 bits (257), Expect = 2e-21
 Identities = 87/366 (23%), Positives = 157/366 (42%), Gaps = 79/366 (21%)

Query: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332
            ALY+ SP +  R +  K++ H +F+ +++  I  NCV +A   P   P  T+ V      
Sbjct: 110  ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP---PPWTKYV-----E 161

Query: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392
            Y FTAI+  E +VK++A G       +L+  WN LD  +++++     V          L
Sbjct: 162  YTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------L 212

Query: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452
            G +  LR  R LR L+ IS   GLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 213  GNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272

Query: 1453 KGKF-----------------------------YYCEGPDT-------------RNISTK 1470
             G                                Y   P+               N S  
Sbjct: 273  MGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDA 332

Query: 1471 AQCRAAHYRWVRRKYN-------FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQP 1523
              C    YR ++   N       FD+   A ++LF L ++D W  +           QQ 
Sbjct: 333  GTCPEG-YRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQT 381

Query: 1524 VQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRLRRL 1581
            +++     +++F+  + + SF+++N+ + VV   + +  Q    E EE  +R ++ +  L
Sbjct: 382  LRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEML 441

Query: 1582 ERRRRS 1587
            ++   +
Sbjct: 442  KKEHEA 447



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 103/400 (25%), Positives = 168/400 (42%), Gaps = 75/400 (18%)

Query: 88   RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCN--ILEAFDAFIFA 145
            R R  C  +V + WFE   + +I+L+   L      ED+     +    +LE  D     
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAI 198
             F +EM++K VA   +G K Y  + W  LDF IV       VA  + ++  G    + ++
Sbjct: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG---PIKSL 1302

Query: 199  RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258
            RT+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    
Sbjct: 1303 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-G 1361

Query: 259  RCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLG 318
            RC   +      N T +                     N   +C        L +   L 
Sbjct: 1362 RCINQTEGDLPLNYTIV---------------------NNKSQC------ESLNLTGELY 1394

Query: 319  WEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLE 378
            W    +   + VGA   A +    +                 + +I YA       +   
Sbjct: 1395 W-TKVKVNFDNVGAGYLALLQVATFK---------------GWMDIMYA------AVDSR 1432

Query: 379  GWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMRE 435
            G+ +   +  + + +  F+ F   II GSFF +NL + VI   F++ K++   +   M E
Sbjct: 1433 GYEEQPQWEYNLYMYIYFVIF---IIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE 1489

Query: 436  QRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRS 475
            ++ ++ +    L S          L KY G IF  V +++
Sbjct: 1490 EQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1529



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 75/289 (25%), Positives = 134/289 (46%), Gaps = 43/289 (14%)

Query: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833
            G++W         IV+  +F   I+  IL+++ ++  E  Y E+ + +   LE ++ +FT
Sbjct: 1188 GKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFT 1247

Query: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIV----GQAD-GGLSVLRTFRL 888
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V    G A+ G +  LRT R 
Sbjct: 1248 YVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRA 1307

Query: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS--LKTD 946
            LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  KF   +   
Sbjct: 1308 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQT 1367

Query: 947  TGD-----TVPDRK-------------------NFDSLLWAIVTVFQILTQEDWNVVLY- 981
             GD     T+ + K                   NFD++    + + Q+ T + W  ++Y 
Sbjct: 1368 EGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYA 1427

Query: 982  ----NGMASTSSW-----AALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
                 G      W       +YFV  + FG++   NL + ++++ F  +
Sbjct: 1428 AVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1476



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 75/289 (25%), Positives = 130/289 (44%), Gaps = 40/289 (13%)

Query: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841
            + G +  IV  + F   IM  I +N ++M VE  +Q  E  N L   N++F ++F  E +
Sbjct: 1517 YQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECI 1576

Query: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLR 890
            +KL A     Y  N +NIFD ++V++S   IVG     +            V+R  R+ R
Sbjct: 1577 VKLAALRHY-YFTNSWNIFDFVVVILS---IVGTVLSDIIQKYFFSPTLFRVIRLARIGR 1632

Query: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950
            +L+L+R    +R  L  L+ ++  +     LL L +FI+SI GM  F     +K + G  
Sbjct: 1633 ILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA---YVKWEAG-- 1687

Query: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL--------------------YNGMASTSSW 990
            + D  NF +   +++ +FQI T   W+ +L                      G   + + 
Sbjct: 1688 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAV 1747

Query: 991  AALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039
              L+F   +     ++ N+ +AI++E F    + +     ED   + +E
Sbjct: 1748 GILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYE 1796



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 41/173 (23%), Positives = 89/173 (51%), Gaps = 21/173 (12%)

Query: 1603 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1662
            + P RR+   +      ++ I   I  N + M+ +H   P +     KY  Y FT ++ F
Sbjct: 117  FHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTF 170

Query: 1663 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1718
            E+ +K++A GF      F +D WN LD +++   +M  T E +++          +  +R
Sbjct: 171  ESLVKILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGN--------VSALR 219

Query: 1719 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771
              R+ R LK + + +G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF
Sbjct: 220  TFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)

Query: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
           +V +P+ +    + I+LN     +F   E     SE   +L+  +      F  EM  K+
Sbjct: 713 VVMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKI 768

Query: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215
           +AL  +    Y    WN  D  IV+  +ME  L   + +LS +R+ R+LR  +     P+
Sbjct: 769 IALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPT 824

Query: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
           +  L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 49/165 (29%), Positives = 76/165 (46%), Gaps = 15/165 (9%)

Query: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
            +V    F+   M +I LN VT+ +    E  +   E+ NIL   +    A F  E ++K+
Sbjct: 1524 IVTKQAFDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKL 1579

Query: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDG-------HNVSLSAIRTVRVLRPLR 208
             AL  +    Y  ++WN  DF +V+  ++   L                IR  R+ R LR
Sbjct: 1580 AALRHY----YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1635

Query: 209  AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253
             I     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1636 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 28/97 (28%), Positives = 48/97 (49%), Gaps = 14/97 (14%)

Query: 1779 DNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPV 1838
            +NP  G   + +F +F  AFL LFR+ T D W  + + TLR   +           +  +
Sbjct: 346  ENPDHG---YTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK-----------IYMI 391

Query: 1839 YFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAE 1875
            +F+  + +  F LVN+++AV+    EE N+    + E
Sbjct: 392  FFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428



 Score = 32.7 bits (73), Expect = 4.3
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 366 YAWIAIFQVITLEGWVDIMYYVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 423
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943


>gi|150417967 voltage-gated sodium channel type V alpha isoform c
            [Homo sapiens]
          Length = 2016

 Score =  446 bits (1147), Expect = e-124
 Identities = 319/1162 (27%), Positives = 554/1162 (47%), Gaps = 136/1162 (11%)

Query: 778  LWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFA 837
            LW++    ++ +V   +    I M I++NTL M +E++    E    L++ N+VFT +F 
Sbjct: 702  LWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFT 761

Query: 838  LEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRF 897
             EM  K++A  P  Y +  +NIFD IIV++S+ E+       LSVLR+FRLLRV KL + 
Sbjct: 762  AEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 898  LPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNF 957
             P L   + ++  ++  +     +L + +FIF+++GM LFG  +S   D+   +  R + 
Sbjct: 822  WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHM 881

Query: 958  DSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAILVE 1016
                 A + +F+IL  E W   +++ M  S  S   L F+ +M  GN V+ NL +A+L+ 
Sbjct: 882  MDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLS 940

Query: 1017 GFQAEGDANRSDTDEDKTSVHFEEDFHK----LRELQTTELKMCS--LAVTPN--GHLEG 1068
             F A+   N +  DED+   + +    +    LR ++ T    C   L   P     L  
Sbjct: 941  SFSAD---NLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA 997

Query: 1069 RGSLSPPLIMCTAATPMP--TPKSSPFLDAAPSLPDSRRGSSSSGDPP------------ 1114
            +G L  P  + T  +P P  T K  P           + G  + GDP             
Sbjct: 998  QGQL--PSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESD 1055

Query: 1115 -----------LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGER 1163
                       LG ++  +  + S     GP     SR  +WS +    S +        
Sbjct: 1056 TDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSR--TWSQVSATASSE-------- 1105

Query: 1164 ESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVA 1223
                  E   S  D  +  +A               +P+       P   C +     + 
Sbjct: 1106 -----AEASASQADWRQQWKA---------------EPQAPGCGETPEDSCSEGSTADMT 1145

Query: 1224 LPSDFFLRIDSHREDAAELDDDSEDSC-----CLRLHKVLEPYKPQWCRSREAWALYLFS 1278
              ++   +I    +D  + +D   + C     C  +     P K  W             
Sbjct: 1146 NTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWW------------- 1192

Query: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338
               R R +C  ++ H  F+  ++  I L+   +A E   ++   T +V L  ++ +FT +
Sbjct: 1193 ---RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYV 1249

Query: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398
            FV EM++K VA G       Y  ++W  LD L+V VSLV +V   A+  G   +G ++ L
Sbjct: 1250 FVLEMLLKWVAYGFKK----YFTNAWCWLDFLIVDVSLVSLV---ANTLGFAEMGPIKSL 1302

Query: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458
            R LR LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKF  
Sbjct: 1303 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1362

Query: 1459 C----EGPDTRN---ISTKAQCRAAHYR----WVRRKYNFDNLGQALMSLFVLSSKDGWV 1507
            C    EG    N   ++ K+QC + +      W + K NFDN+G   ++L  +++  GW+
Sbjct: 1363 CINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWM 1422

Query: 1508 NIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEA 1567
            +IMY  +D+ G ++QP   +N +M +YF+ F++  SFF LN+F+GV+++NF++ ++    
Sbjct: 1423 DIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG 1482

Query: 1568 EEA-RRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFI 1626
            ++     E+K+     ++  S  P     ++P     +  +  I  + T    D+ I F+
Sbjct: 1483 QDIFMTEEQKKYYNAMKKLGSKKP-----QKPIPRPLNKYQGFIFDIVTKQAFDVTIMFL 1537

Query: 1627 ICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDL 1686
            IC+N++TM +E  +Q       L   N +F  +F  E  +KL A     +F + WN  D 
Sbjct: 1538 ICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDF 1596

Query: 1687 AIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQAL 1746
             +V+LS++G  L +I        +PT+ R++R+ RI R+L+L++ A G+R LL  ++ +L
Sbjct: 1597 VVVILSIVGTVLSDIIQKYF--FSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1654

Query: 1747 PQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVST 1806
            P + N+GLL  L+ FIY+  G+  F  ++        G+     F  F  + L LF+++T
Sbjct: 1655 PALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITT 1709

Query: 1807 GDNWNGIMK-----------DTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVV 1855
               W+G++             TL   +     C S  PA+  ++F T+++++  ++VN+ 
Sbjct: 1710 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGS--PAVGILFFTTYIIISFLIVVNMY 1767

Query: 1856 VAVLMKHLEESNKEAREDAELD 1877
            +A+++++   + +E+ E    D
Sbjct: 1768 IAIILENFSVATEESTEPLSED 1789



 Score =  145 bits (366), Expect = 5e-34
 Identities = 203/889 (22%), Positives = 354/889 (39%), Gaps = 190/889 (21%)

Query: 788  RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847
            +I+    F+  IM  IL N + M       P   T  +E +   FT+++  E L+K+LA 
Sbjct: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179

Query: 848  G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902
            G       ++R+P+N  D  +I++  V E +    G LS LRTFR+LR LK +  +P L+
Sbjct: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKL--GNLSALRTFRVLRALKTISVIPGLK 237

Query: 903  RQLVVLVKTMDNVA------TFCTLLMLFIFIFSILGMHLFGC----------------- 939
              +  L++++  +A       FC  +   I +   +G     C                 
Sbjct: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297

Query: 940  ---------------KFSLKTDTGDTV-----------------------PDR--KNFDS 959
                            + LK  T D +                       PD    +FDS
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357

Query: 960  LLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019
              WA + +F+++TQ+ W  +    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417

Query: 1020 AEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMC 1079
             +  A  ++T+E       E+ F +  E+    LK    A+T    + G  ++S   +  
Sbjct: 418  EQNQATIAETEEK------EKRFQEAMEM----LKKEHEALT----IRGVDTVSRSSLEM 463

Query: 1080 TAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLG-DQKPPASLRSSPCAPWGPSGAW 1138
            +   P+ + +              RR   SSG    G D+ P +     P A    S   
Sbjct: 464  SPLAPVNSHERR----------SKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTR 513

Query: 1139 SSRRSSW---SSLGRAPSLKRRGQCGER-----ESLLSGEGKG--------------STD 1176
               R+S    SS G   + +RR    E      E+  +GE +               S  
Sbjct: 514  GLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQ 573

Query: 1177 DEAEDGRAAPGPRATPLRRA----------------ESLDPRP--LRPAAL--PP--TKC 1214
             +   G +APG      + +                E+  P    LRP  L  PP  T  
Sbjct: 574  GQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTP 633

Query: 1215 RDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYK----PQWCRSRE 1270
             +  G    L S     +D   E  A     S  S      + LE  +    P W R  +
Sbjct: 634  SEEPGGPQMLTSQAPC-VDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ 692

Query: 1271 AWALYLFSPQ-NRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLS 1329
             + ++   P     +   + V+     D  + + I LN + +ALE  ++     E   L 
Sbjct: 693  RYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQ 750

Query: 1330 VSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGA 1389
            V N +FT IF AEM  K++AL      + Y Q  WN+ D ++V++SL+++        G 
Sbjct: 751  VGNLVFTGIFTAEMTFKIIALD----PYYYFQQGWNIFDSIIVILSLMEL--------GL 798

Query: 1390 KILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGV 1449
              +  L VLR  R LR  ++    P L  +++ + +S+  +GN+ L+      IF ++G+
Sbjct: 799  SRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 858

Query: 1450 QLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNI 1509
            QLF GK Y             ++ R +    + R +  D     L+   +L  +  W+  
Sbjct: 859  QLF-GKNY-------------SELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE--WIET 902

Query: 1510 MYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558
            M+D ++  G             LL F+  ++I +  VLN+F+ +++ +F
Sbjct: 903  MWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942



 Score =  112 bits (281), Expect = 3e-24
 Identities = 89/356 (25%), Positives = 170/356 (47%), Gaps = 49/356 (13%)

Query: 90  RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIF-AFFA 148
           R   ++++ +  F  + M  I+ NCV +    P    +           +  + F A + 
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK-----------YVEYTFTAIYT 169

Query: 149 VEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPL 207
            E ++K++A G       +L D WN LDF +++   +  ++   N  LSA+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN--LSALRTFRVLRAL 227

Query: 208 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFV 267
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C       
Sbjct: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV------ 281

Query: 268 RNNNLTFLRPYYQTEEGE----ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYT 323
              N T L     + E +    E+  +  S  +N + K     G  ++ + C    +A T
Sbjct: 282 --RNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLK----NGTSDVLL-CGNSSDAGT 334

Query: 324 QPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDI 383
            P+                 Y   ++G+ NP +G  +FD+  +A++A+F+++T + W  +
Sbjct: 335 CPEG----------------YRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERL 377

Query: 384 MYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRAR 439
               + +      I+F+L+I +GSF+++NL L V+A  + E  Q       E+  R
Sbjct: 378 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKR 433



 Score =  112 bits (281), Expect = 3e-24
 Identities = 73/269 (27%), Positives = 132/269 (49%), Gaps = 21/269 (7%)

Query: 1618 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1677
            + DL IT  I +N + M++EHYN     +E L+  N VFT +F  E   K++A     +F
Sbjct: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777

Query: 1678 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1737
            +  WN  D  IV+LSLM + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827

Query: 1738 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMA 1797
            L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      +   GL       +F  A
Sbjct: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887

Query: 1798 FLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVA 1857
            FL +FR+  G+ W   M D +    +          +L  + F+  +++   V++N+ +A
Sbjct: 888  FLIIFRILCGE-WIETMWDCMEVSGQ----------SLCLLVFLLVMVIGNLVVLNLFLA 936

Query: 1858 VLMKHLEESNKEAREDAELDAEIELEMAQ 1886
            +L+      N  A ++      ++L +A+
Sbjct: 937  LLLSSFSADNLTAPDEDREMNNLQLALAR 965



 Score =  108 bits (271), Expect = 5e-23
 Identities = 89/366 (24%), Positives = 159/366 (43%), Gaps = 79/366 (21%)

Query: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332
            ALY+ SP +  R +  K++ H +F+ +++  I  NCV +A   P   P  T+ V      
Sbjct: 110  ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP---PPWTKYV-----E 161

Query: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392
            Y FTAI+  E +VK++A G       +L+  WN LD  +++++ V   +          L
Sbjct: 162  YTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------L 212

Query: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452
            G L  LR  R LR L+ IS  PGLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 213  GNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272

Query: 1453 KGKF-----------------------------YYCEGPDT-------------RNISTK 1470
             G                                Y   P+               N S  
Sbjct: 273  MGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDA 332

Query: 1471 AQCRAAHYRWVRRKYN-------FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQP 1523
              C    YR ++   N       FD+   A ++LF L ++D W  +           QQ 
Sbjct: 333  GTCPEG-YRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQT 381

Query: 1524 VQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRLRRL 1581
            +++     +++F+  + + SF+++N+ + VV   + +  Q    E EE  +R ++ +  L
Sbjct: 382  LRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEML 441

Query: 1582 ERRRRS 1587
            ++   +
Sbjct: 442  KKEHEA 447



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 103/400 (25%), Positives = 168/400 (42%), Gaps = 75/400 (18%)

Query: 88   RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCN--ILEAFDAFIFA 145
            R R  C  +V + WFE   + +I+L+   L      ED+     +    +LE  D     
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAI 198
             F +EM++K VA   +G K Y  + W  LDF IV       VA  + ++  G    + ++
Sbjct: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG---PIKSL 1302

Query: 199  RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258
            RT+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    
Sbjct: 1303 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-G 1361

Query: 259  RCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLG 318
            RC   +      N T +                     N   +C        L +   L 
Sbjct: 1362 RCINQTEGDLPLNYTIV---------------------NNKSQC------ESLNLTGELY 1394

Query: 319  WEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLE 378
            W    +   + VGA   A +    +                 + +I YA       +   
Sbjct: 1395 W-TKVKVNFDNVGAGYLALLQVATFK---------------GWMDIMYA------AVDSR 1432

Query: 379  GWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMRE 435
            G+ +   +  + + +  F+ F   II GSFF +NL + VI   F++ K++   +   M E
Sbjct: 1433 GYEEQPQWEYNLYMYIYFVIF---IIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE 1489

Query: 436  QRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRS 475
            ++ ++ +    L S          L KY G IF  V +++
Sbjct: 1490 EQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1529



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 75/289 (25%), Positives = 134/289 (46%), Gaps = 43/289 (14%)

Query: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833
            G++W         IV+  +F   I+  IL+++ ++  E  Y E+ + +   LE ++ +FT
Sbjct: 1188 GKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFT 1247

Query: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIV----GQAD-GGLSVLRTFRL 888
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V    G A+ G +  LRT R 
Sbjct: 1248 YVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRA 1307

Query: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS--LKTD 946
            LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  KF   +   
Sbjct: 1308 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQT 1367

Query: 947  TGD-----TVPDRK-------------------NFDSLLWAIVTVFQILTQEDWNVVLY- 981
             GD     T+ + K                   NFD++    + + Q+ T + W  ++Y 
Sbjct: 1368 EGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYA 1427

Query: 982  ----NGMASTSSW-----AALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
                 G      W       +YFV  + FG++   NL + ++++ F  +
Sbjct: 1428 AVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1476



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 75/289 (25%), Positives = 130/289 (44%), Gaps = 40/289 (13%)

Query: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841
            + G +  IV  + F   IM  I +N ++M VE  +Q  E  N L   N++F ++F  E +
Sbjct: 1517 YQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECI 1576

Query: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLR 890
            +KL A     Y  N +NIFD ++V++S   IVG     +            V+R  R+ R
Sbjct: 1577 VKLAALRHY-YFTNSWNIFDFVVVILS---IVGTVLSDIIQKYFFSPTLFRVIRLARIGR 1632

Query: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950
            +L+L+R    +R  L  L+ ++  +     LL L +FI+SI GM  F     +K + G  
Sbjct: 1633 ILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA---YVKWEAG-- 1687

Query: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL--------------------YNGMASTSSW 990
            + D  NF +   +++ +FQI T   W+ +L                      G   + + 
Sbjct: 1688 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAV 1747

Query: 991  AALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039
              L+F   +     ++ N+ +AI++E F    + +     ED   + +E
Sbjct: 1748 GILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYE 1796



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 40/173 (23%), Positives = 89/173 (51%), Gaps = 21/173 (12%)

Query: 1603 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1662
            + P RR+   +      ++ I   I  N + M+ +H   P +     KY  Y FT ++ F
Sbjct: 117  FHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTF 170

Query: 1663 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1718
            E+ +K++A GF      F +D WN LD ++++++ +   ++   +SA           +R
Sbjct: 171  ESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSA-----------LR 219

Query: 1719 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771
              R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF
Sbjct: 220  TFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)

Query: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
           +V +P+ +    + I+LN     +F   E     SE   +L+  +      F  EM  K+
Sbjct: 713 VVMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKI 768

Query: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215
           +AL  +    Y    WN  D  IV+  +ME  L   + +LS +R+ R+LR  +     P+
Sbjct: 769 IALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPT 824

Query: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
           +  L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 49/165 (29%), Positives = 76/165 (46%), Gaps = 15/165 (9%)

Query: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
            +V    F+   M +I LN VT+ +    E  +   E+ NIL   +    A F  E ++K+
Sbjct: 1524 IVTKQAFDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKL 1579

Query: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDG-------HNVSLSAIRTVRVLRPLR 208
             AL  +    Y  ++WN  DF +V+  ++   L                IR  R+ R LR
Sbjct: 1580 AALRHY----YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1635

Query: 209  AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253
             I     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1636 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 28/97 (28%), Positives = 48/97 (49%), Gaps = 14/97 (14%)

Query: 1779 DNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPV 1838
            +NP  G   + +F +F  AFL LFR+ T D W  + + TLR   +           +  +
Sbjct: 346  ENPDHG---YTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK-----------IYMI 391

Query: 1839 YFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAE 1875
            +F+  + +  F LVN+++AV+    EE N+    + E
Sbjct: 392  FFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428



 Score = 32.7 bits (73), Expect = 4.3
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 366 YAWIAIFQVITLEGWVDIMYYVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 423
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943


>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
            sapiens]
          Length = 2015

 Score =  446 bits (1146), Expect = e-124
 Identities = 320/1162 (27%), Positives = 555/1162 (47%), Gaps = 137/1162 (11%)

Query: 778  LWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFA 837
            LW++    ++ +V   +    I M I++NTL M +E++    E    L++ N+VFT +F 
Sbjct: 702  LWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFT 761

Query: 838  LEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRF 897
             EM  K++A  P  Y +  +NIFD IIV++S+ E+       LSVLR+FRLLRV KL + 
Sbjct: 762  AEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 898  LPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNF 957
             P L   + ++  ++  +     +L + +FIF+++GM LFG  +S   D+   +  R + 
Sbjct: 822  WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHM 881

Query: 958  DSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAILVE 1016
                 A + +F+IL  E W   +++ M  S  S   L F+ +M  GN V+ NL +A+L+ 
Sbjct: 882  MDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLS 940

Query: 1017 GFQAEGDANRSDTDEDKTSVHFEEDFHK----LRELQTTELKMCS--LAVTPN--GHLEG 1068
             F A+   N +  DED+   + +    +    LR ++ T    C   L   P     L  
Sbjct: 941  SFSAD---NLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA 997

Query: 1069 RGSLSPPLIMCTAATPMP--TPKSSPFLDAAPSLPDSRRGSSSSGDPP------------ 1114
            +G L  P  + T  +P P  T K  P           + G  + GDP             
Sbjct: 998  QGQL--PSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESD 1055

Query: 1115 -----------LGDQKPPASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGER 1163
                       LG ++  +   S P +  GP     SR  +WS +    S +        
Sbjct: 1056 TDDQEEDEENSLGTEEESSKQESQPVSG-GPEAPPDSR--TWSQVSATASSE-------- 1104

Query: 1164 ESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVA 1223
                  E   S  D  +  +A               +P+       P   C +     + 
Sbjct: 1105 -----AEASASQADWRQQWKA---------------EPQAPGCGETPEDSCSEGSTADMT 1144

Query: 1224 LPSDFFLRIDSHREDAAELDDDSEDSC-----CLRLHKVLEPYKPQWCRSREAWALYLFS 1278
              ++   +I    +D  + +D   + C     C  +     P K  W             
Sbjct: 1145 NTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWW------------- 1191

Query: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338
               R R +C  ++ H  F+  ++  I L+   +A E   ++   T +V L  ++ +FT +
Sbjct: 1192 ---RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYV 1248

Query: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398
            FV EM++K VA G       Y  ++W  LD L+V VSLV +V   A+  G   +G ++ L
Sbjct: 1249 FVLEMLLKWVAYGFKK----YFTNAWCWLDFLIVDVSLVSLV---ANTLGFAEMGPIKSL 1301

Query: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458
            R LR LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKF  
Sbjct: 1302 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1361

Query: 1459 C----EGPDTRN---ISTKAQCRAAHYR----WVRRKYNFDNLGQALMSLFVLSSKDGWV 1507
            C    EG    N   ++ K+QC + +      W + K NFDN+G   ++L  +++  GW+
Sbjct: 1362 CINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWM 1421

Query: 1508 NIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEA 1567
            +IMY  +D+ G ++QP   +N +M +YF+ F++  SFF LN+F+GV+++NF++ ++    
Sbjct: 1422 DIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG 1481

Query: 1568 EEA-RRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFI 1626
            ++     E+K+     ++  S  P     ++P     +  +  I  + T    D+ I F+
Sbjct: 1482 QDIFMTEEQKKYYNAMKKLGSKKP-----QKPIPRPLNKYQGFIFDIVTKQAFDVTIMFL 1536

Query: 1627 ICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDL 1686
            IC+N++TM +E  +Q       L   N +F  +F  E  +KL A     +F + WN  D 
Sbjct: 1537 ICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDF 1595

Query: 1687 AIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQAL 1746
             +V+LS++G  L +I        +PT+ R++R+ RI R+L+L++ A G+R LL  ++ +L
Sbjct: 1596 VVVILSIVGTVLSDIIQKYF--FSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1653

Query: 1747 PQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVST 1806
            P + N+GLL  L+ FIY+  G+  F  ++        G+     F  F  + L LF+++T
Sbjct: 1654 PALFNIGLLLFLVMFIYSIFGMANFAYVKWE-----AGIDDMFNFQTFANSMLCLFQITT 1708

Query: 1807 GDNWNGIMK-----------DTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVV 1855
               W+G++             TL   +     C S  PA+  ++F T+++++  ++VN+ 
Sbjct: 1709 SAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGS--PAVGILFFTTYIIISFLIVVNMY 1766

Query: 1856 VAVLMKHLEESNKEAREDAELD 1877
            +A+++++   + +E+ E    D
Sbjct: 1767 IAIILENFSVATEESTEPLSED 1788



 Score =  142 bits (357), Expect = 5e-33
 Identities = 201/889 (22%), Positives = 352/889 (39%), Gaps = 190/889 (21%)

Query: 788  RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847
            +I+    F+  IM  IL N + M       P   T  +E +   FT+++  E L+K+LA 
Sbjct: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179

Query: 848  G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902
            G       ++R+P+N  D  +I++    E V    G +S LRTFR+LR LK +  +  L+
Sbjct: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237

Query: 903  RQLVVLVKTMDNVA------TFCTLLMLFIFIFSILGMHLFGC----------------- 939
              +  L++++  +A       FC  +   I +   +G     C                 
Sbjct: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297

Query: 940  ---------------KFSLKTDTGDTV-----------------------PDR--KNFDS 959
                            + LK  T D +                       PD    +FDS
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357

Query: 960  LLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019
              WA + +F+++TQ+ W  +    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417

Query: 1020 AEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMC 1079
             +  A  ++T+E       E+ F +  E+    LK    A+T    + G  ++S   +  
Sbjct: 418  EQNQATIAETEEK------EKRFQEAMEM----LKKEHEALT----IRGVDTVSRSSLEM 463

Query: 1080 TAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLG-DQKPPASLRSSPCAPWGPSGAW 1138
            +   P+ + +              RR   SSG    G D+ P +     P A    S   
Sbjct: 464  SPLAPVNSHERR----------SKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTR 513

Query: 1139 SSRRSSW---SSLGRAPSLKRRGQCGER-----ESLLSGEGKG--------------STD 1176
               R+S    SS G   + +RR    E      E+  +GE +               S  
Sbjct: 514  GLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQ 573

Query: 1177 DEAEDGRAAPGPRATPLRRA----------------ESLDPRP--LRPAAL--PP--TKC 1214
             +   G +APG      + +                E+  P    LRP  L  PP  T  
Sbjct: 574  GQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTP 633

Query: 1215 RDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYK----PQWCRSRE 1270
             +  G    L S     +D   E  A     S  S      + LE  +    P W R  +
Sbjct: 634  SEEPGGPQMLTSQAPC-VDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ 692

Query: 1271 AWALYLFSPQ-NRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLS 1329
             + ++   P     +   + V+     D  + + I LN + +ALE  ++     E   L 
Sbjct: 693  RYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQ 750

Query: 1330 VSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGA 1389
            V N +FT IF AEM  K++AL      + Y Q  WN+ D ++V++SL+++        G 
Sbjct: 751  VGNLVFTGIFTAEMTFKIIALD----PYYYFQQGWNIFDSIIVILSLMEL--------GL 798

Query: 1390 KILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGV 1449
              +  L VLR  R LR  ++    P L  +++ + +S+  +GN+ L+      IF ++G+
Sbjct: 799  SRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 858

Query: 1450 QLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNI 1509
            QLF GK Y             ++ R +    + R +  D     L+   +L  +  W+  
Sbjct: 859  QLF-GKNY-------------SELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE--WIET 902

Query: 1510 MYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558
            M+D ++  G             LL F+  ++I +  VLN+F+ +++ +F
Sbjct: 903  MWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942



 Score =  112 bits (281), Expect = 3e-24
 Identities = 73/269 (27%), Positives = 132/269 (49%), Gaps = 21/269 (7%)

Query: 1618 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1677
            + DL IT  I +N + M++EHYN     +E L+  N VFT +F  E   K++A     +F
Sbjct: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777

Query: 1678 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1737
            +  WN  D  IV+LSLM + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827

Query: 1738 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMA 1797
            L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      +   GL       +F  A
Sbjct: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887

Query: 1798 FLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVA 1857
            FL +FR+  G+ W   M D +    +          +L  + F+  +++   V++N+ +A
Sbjct: 888  FLIIFRILCGE-WIETMWDCMEVSGQ----------SLCLLVFLLVMVIGNLVVLNLFLA 936

Query: 1858 VLMKHLEESNKEAREDAELDAEIELEMAQ 1886
            +L+      N  A ++      ++L +A+
Sbjct: 937  LLLSSFSADNLTAPDEDREMNNLQLALAR 965



 Score =  109 bits (273), Expect = 3e-23
 Identities = 89/356 (25%), Positives = 168/356 (47%), Gaps = 49/356 (13%)

Query: 90  RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIF-AFFA 148
           R   ++++ +  F  + M  I+ NCV +    P    +           +  + F A + 
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK-----------YVEYTFTAIYT 169

Query: 149 VEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPL 207
            E ++K++A G       +L D WN LDF +++       +D  NVS  A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227

Query: 208 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFV 267
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C       
Sbjct: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV------ 281

Query: 268 RNNNLTFLRPYYQTEEGE----ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYT 323
              N T L     + E +    E+  +  S  +N + K     G  ++ + C    +A T
Sbjct: 282 --RNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLK----NGTSDVLL-CGNSSDAGT 334

Query: 324 QPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDI 383
            P+                 Y   ++G+ NP +G  +FD+  +A++A+F+++T + W  +
Sbjct: 335 CPEG----------------YRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERL 377

Query: 384 MYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRAR 439
               + +      I+F+L+I +GSF+++NL L V+A  + E  Q       E+  R
Sbjct: 378 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKR 433



 Score =  103 bits (257), Expect = 2e-21
 Identities = 87/366 (23%), Positives = 157/366 (42%), Gaps = 79/366 (21%)

Query: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332
            ALY+ SP +  R +  K++ H +F+ +++  I  NCV +A   P   P  T+ V      
Sbjct: 110  ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP---PPWTKYV-----E 161

Query: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392
            Y FTAI+  E +VK++A G       +L+  WN LD  +++++     V          L
Sbjct: 162  YTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------L 212

Query: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452
            G +  LR  R LR L+ IS   GLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 213  GNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272

Query: 1453 KGKF-----------------------------YYCEGPDT-------------RNISTK 1470
             G                                Y   P+               N S  
Sbjct: 273  MGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDA 332

Query: 1471 AQCRAAHYRWVRRKYN-------FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQP 1523
              C    YR ++   N       FD+   A ++LF L ++D W  +           QQ 
Sbjct: 333  GTCPEG-YRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQT 381

Query: 1524 VQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRLRRL 1581
            +++     +++F+  + + SF+++N+ + VV   + +  Q    E EE  +R ++ +  L
Sbjct: 382  LRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEML 441

Query: 1582 ERRRRS 1587
            ++   +
Sbjct: 442  KKEHEA 447



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 103/400 (25%), Positives = 168/400 (42%), Gaps = 75/400 (18%)

Query: 88   RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCN--ILEAFDAFIFA 145
            R R  C  +V + WFE   + +I+L+   L      ED+     +    +LE  D     
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1247

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAI 198
             F +EM++K VA   +G K Y  + W  LDF IV       VA  + ++  G    + ++
Sbjct: 1248 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG---PIKSL 1301

Query: 199  RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258
            RT+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    
Sbjct: 1302 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-G 1360

Query: 259  RCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLG 318
            RC   +      N T +                     N   +C        L +   L 
Sbjct: 1361 RCINQTEGDLPLNYTIV---------------------NNKSQC------ESLNLTGELY 1393

Query: 319  WEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLE 378
            W    +   + VGA   A +    +                 + +I YA       +   
Sbjct: 1394 W-TKVKVNFDNVGAGYLALLQVATFK---------------GWMDIMYA------AVDSR 1431

Query: 379  GWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMRE 435
            G+ +   +  + + +  F+ F   II GSFF +NL + VI   F++ K++   +   M E
Sbjct: 1432 GYEEQPQWEYNLYMYIYFVIF---IIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE 1488

Query: 436  QRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRS 475
            ++ ++ +    L S          L KY G IF  V +++
Sbjct: 1489 EQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1528



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 75/289 (25%), Positives = 134/289 (46%), Gaps = 43/289 (14%)

Query: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833
            G++W         IV+  +F   I+  IL+++ ++  E  Y E+ + +   LE ++ +FT
Sbjct: 1187 GKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFT 1246

Query: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIV----GQAD-GGLSVLRTFRL 888
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V    G A+ G +  LRT R 
Sbjct: 1247 YVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRA 1306

Query: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS--LKTD 946
            LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  KF   +   
Sbjct: 1307 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQT 1366

Query: 947  TGD-----TVPDRK-------------------NFDSLLWAIVTVFQILTQEDWNVVLY- 981
             GD     T+ + K                   NFD++    + + Q+ T + W  ++Y 
Sbjct: 1367 EGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYA 1426

Query: 982  ----NGMASTSSW-----AALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
                 G      W       +YFV  + FG++   NL + ++++ F  +
Sbjct: 1427 AVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1475



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 75/289 (25%), Positives = 130/289 (44%), Gaps = 40/289 (13%)

Query: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841
            + G +  IV  + F   IM  I +N ++M VE  +Q  E  N L   N++F ++F  E +
Sbjct: 1516 YQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECI 1575

Query: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLR 890
            +KL A     Y  N +NIFD ++V++S   IVG     +            V+R  R+ R
Sbjct: 1576 VKLAALRHY-YFTNSWNIFDFVVVILS---IVGTVLSDIIQKYFFSPTLFRVIRLARIGR 1631

Query: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950
            +L+L+R    +R  L  L+ ++  +     LL L +FI+SI GM  F     +K + G  
Sbjct: 1632 ILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA---YVKWEAG-- 1686

Query: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL--------------------YNGMASTSSW 990
            + D  NF +   +++ +FQI T   W+ +L                      G   + + 
Sbjct: 1687 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAV 1746

Query: 991  AALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039
              L+F   +     ++ N+ +AI++E F    + +     ED   + +E
Sbjct: 1747 GILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYE 1795



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 41/173 (23%), Positives = 89/173 (51%), Gaps = 21/173 (12%)

Query: 1603 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1662
            + P RR+   +      ++ I   I  N + M+ +H   P +     KY  Y FT ++ F
Sbjct: 117  FHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTF 170

Query: 1663 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1718
            E+ +K++A GF      F +D WN LD +++   +M  T E +++          +  +R
Sbjct: 171  ESLVKILARGFCLHAFTFLRDPWNWLDFSVI---IMAYTTEFVDLGN--------VSALR 219

Query: 1719 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771
              R+ R LK + + +G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF
Sbjct: 220  TFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)

Query: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
           +V +P+ +    + I+LN     +F   E     SE   +L+  +      F  EM  K+
Sbjct: 713 VVMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKI 768

Query: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215
           +AL  +    Y    WN  D  IV+  +ME  L   + +LS +R+ R+LR  +     P+
Sbjct: 769 IALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPT 824

Query: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
           +  L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 49/165 (29%), Positives = 76/165 (46%), Gaps = 15/165 (9%)

Query: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
            +V    F+   M +I LN VT+ +    E  +   E+ NIL   +    A F  E ++K+
Sbjct: 1523 IVTKQAFDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKL 1578

Query: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDG-------HNVSLSAIRTVRVLRPLR 208
             AL  +    Y  ++WN  DF +V+  ++   L                IR  R+ R LR
Sbjct: 1579 AALRHY----YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1634

Query: 209  AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253
             I     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1635 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1679



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 28/97 (28%), Positives = 48/97 (49%), Gaps = 14/97 (14%)

Query: 1779 DNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPV 1838
            +NP  G   + +F +F  AFL LFR+ T D W  + + TLR   +           +  +
Sbjct: 346  ENPDHG---YTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK-----------IYMI 391

Query: 1839 YFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAE 1875
            +F+  + +  F LVN+++AV+    EE N+    + E
Sbjct: 392  FFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428



 Score = 32.7 bits (73), Expect = 4.3
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 366 YAWIAIFQVITLEGWVDIMYYVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 423
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943


>gi|237512982 voltage-gated sodium channel type V alpha isoform f
            [Homo sapiens]
          Length = 1962

 Score =  444 bits (1141), Expect = e-124
 Identities = 314/1135 (27%), Positives = 548/1135 (48%), Gaps = 136/1135 (11%)

Query: 778  LWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFA 837
            LW++    ++ +V   +    I M I++NTL M +E++    E    L++ N+VFT +F 
Sbjct: 702  LWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFT 761

Query: 838  LEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRF 897
             EM  K++A  P  Y +  +NIFD IIV++S+ E+       LSVLR+FRLLRV KL + 
Sbjct: 762  AEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 898  LPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNF 957
             P L   + ++  ++  +     +L + +FIF+++GM LFG  +S   D+   +  R + 
Sbjct: 822  WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHM 881

Query: 958  DSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAILVE 1016
                 A + +F+IL  E W   +++ M  S  S   L F+ +M  GN V+ NL +A+L+ 
Sbjct: 882  MDFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLS 940

Query: 1017 GFQAEGDANRSDTDEDKTSVHFEEDFHK----LRELQTTELKMCSLAVTPNGHLEGRGSL 1072
             F A+   N +  DED+   + +    +    LR ++ T    C       G L  R   
Sbjct: 941  SFSAD---NLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCC------GLLRQR--- 988

Query: 1073 SPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPW 1132
                           P+    L A   LP S   +  S  PP  ++ PP           
Sbjct: 989  ---------------PQKPAALAAQGQLP-SCIATPYSPPPPETEKVPP----------- 1021

Query: 1133 GPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLS--GEGKGSTDDEAEDGRAAPGPRA 1190
                   +R+ +    G  P    +G  G+ E +       +  TDD+ ED   + G   
Sbjct: 1022 -------TRKETRFEEGEQPG---QGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEE 1071

Query: 1191 TPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSC 1250
               ++              P   C +     +   ++   +I    +D  + +D   + C
Sbjct: 1072 ESSKQT-------------PEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGC 1118

Query: 1251 -----CLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIF 1305
                 C  +     P K  W                R R +C  ++ H  F+  ++  I 
Sbjct: 1119 VRRCPCCAVDTTQAPGKVWW----------------RLRKTCYHIVEHSWFETFIIFMIL 1162

Query: 1306 LNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWN 1365
            L+   +A E   ++   T +V L  ++ +FT +FV EM++K VA G       Y  ++W 
Sbjct: 1163 LSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKK----YFTNAWC 1218

Query: 1366 LLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLIS 1425
             LD L+V VSLV +V   A+  G   +G ++ LR LR LRPLR +SR  G+++VV  L+ 
Sbjct: 1219 WLDFLIVDVSLVSLV---ANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVG 1275

Query: 1426 SLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC----EGPDTRN---ISTKAQCRAAHY 1478
            ++  I N++L+C  F++IF I+GV LF GKF  C    EG    N   ++ K+QC + + 
Sbjct: 1276 AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNL 1335

Query: 1479 R----WVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLY 1534
                 W + K NFDN+G   ++L  +++  GW++IMY  +D+ G ++QP   +N +M +Y
Sbjct: 1336 TGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIY 1395

Query: 1535 FISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEA-RRREEKRLRRLERRRRSTFPSPE 1593
            F+ F++  SFF LN+F+GV+++NF++ ++    ++     E+K+     ++  S  P   
Sbjct: 1396 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKP--- 1452

Query: 1594 AQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCN 1653
              ++P     +  +  I  + T    D+ I F+IC+N++TM +E  +Q       L   N
Sbjct: 1453 --QKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKIN 1510

Query: 1654 YVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTI 1713
             +F  +F  E  +KL A     +F + WN  D  +V+LS++G  L +I        +PT+
Sbjct: 1511 LLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYF--FSPTL 1567

Query: 1714 IRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR 1773
             R++R+ RI R+L+L++ A G+R LL  ++ +LP + N+GLL  L+ FIY+  G+  F  
Sbjct: 1568 FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAY 1627

Query: 1774 LECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMK-----------DTLRECS 1822
            ++        G+     F  F  + L LF+++T   W+G++             TL   +
Sbjct: 1628 VKWE-----AGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSN 1682

Query: 1823 REDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELD 1877
                 C S  PA+  ++F T+++++  ++VN+ +A+++++   + +E+ E    D
Sbjct: 1683 GSRGDCGS--PAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSED 1735



 Score =  145 bits (366), Expect = 5e-34
 Identities = 203/889 (22%), Positives = 354/889 (39%), Gaps = 190/889 (21%)

Query: 788  RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847
            +I+    F+  IM  IL N + M       P   T  +E +   FT+++  E L+K+LA 
Sbjct: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179

Query: 848  G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902
            G       ++R+P+N  D  +I++  V E +    G LS LRTFR+LR LK +  +P L+
Sbjct: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKL--GNLSALRTFRVLRALKTISVIPGLK 237

Query: 903  RQLVVLVKTMDNVA------TFCTLLMLFIFIFSILGMHLFGC----------------- 939
              +  L++++  +A       FC  +   I +   +G     C                 
Sbjct: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297

Query: 940  ---------------KFSLKTDTGDTV-----------------------PDR--KNFDS 959
                            + LK  T D +                       PD    +FDS
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357

Query: 960  LLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019
              WA + +F+++TQ+ W  +    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417

Query: 1020 AEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMC 1079
             +  A  ++T+E       E+ F +  E+    LK    A+T    + G  ++S   +  
Sbjct: 418  EQNQATIAETEEK------EKRFQEAMEM----LKKEHEALT----IRGVDTVSRSSLEM 463

Query: 1080 TAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLG-DQKPPASLRSSPCAPWGPSGAW 1138
            +   P+ + +              RR   SSG    G D+ P +     P A    S   
Sbjct: 464  SPLAPVNSHERR----------SKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTR 513

Query: 1139 SSRRSSW---SSLGRAPSLKRRGQCGER-----ESLLSGEGKG--------------STD 1176
               R+S    SS G   + +RR    E      E+  +GE +               S  
Sbjct: 514  GLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQ 573

Query: 1177 DEAEDGRAAPGPRATPLRRA----------------ESLDPRP--LRPAAL--PP--TKC 1214
             +   G +APG      + +                E+  P    LRP  L  PP  T  
Sbjct: 574  GQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTP 633

Query: 1215 RDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYK----PQWCRSRE 1270
             +  G    L S     +D   E  A     S  S      + LE  +    P W R  +
Sbjct: 634  SEEPGGPQMLTSQAPC-VDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQ 692

Query: 1271 AWALYLFSPQ-NRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLS 1329
             + ++   P     +   + V+     D  + + I LN + +ALE  ++     E   L 
Sbjct: 693  RYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQ 750

Query: 1330 VSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGA 1389
            V N +FT IF AEM  K++AL      + Y Q  WN+ D ++V++SL+++        G 
Sbjct: 751  VGNLVFTGIFTAEMTFKIIALD----PYYYFQQGWNIFDSIIVILSLMEL--------GL 798

Query: 1390 KILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGV 1449
              +  L VLR  R LR  ++    P L  +++ + +S+  +GN+ L+      IF ++G+
Sbjct: 799  SRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 858

Query: 1450 QLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNI 1509
            QLF GK Y             ++ R +    + R +  D     L+   +L  +  W+  
Sbjct: 859  QLF-GKNY-------------SELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE--WIET 902

Query: 1510 MYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558
            M+D ++  G             LL F+  ++I +  VLN+F+ +++ +F
Sbjct: 903  MWDCMEVSG---------QSLCLLVFLLVMVIGNLVVLNLFLALLLSSF 942



 Score =  112 bits (281), Expect = 3e-24
 Identities = 89/356 (25%), Positives = 170/356 (47%), Gaps = 49/356 (13%)

Query: 90  RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIF-AFFA 148
           R   ++++ +  F  + M  I+ NCV +    P    +           +  + F A + 
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTK-----------YVEYTFTAIYT 169

Query: 149 VEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPL 207
            E ++K++A G       +L D WN LDF +++   +  ++   N  LSA+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGN--LSALRTFRVLRAL 227

Query: 208 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFV 267
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C       
Sbjct: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV------ 281

Query: 268 RNNNLTFLRPYYQTEEGE----ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYT 323
              N T L     + E +    E+  +  S  +N + K     G  ++ + C    +A T
Sbjct: 282 --RNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLK----NGTSDVLL-CGNSSDAGT 334

Query: 324 QPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDI 383
            P+                 Y   ++G+ NP +G  +FD+  +A++A+F+++T + W  +
Sbjct: 335 CPEG----------------YRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERL 377

Query: 384 MYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRAR 439
               + +      I+F+L+I +GSF+++NL L V+A  + E  Q       E+  R
Sbjct: 378 YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKR 433



 Score =  112 bits (281), Expect = 3e-24
 Identities = 73/269 (27%), Positives = 132/269 (49%), Gaps = 21/269 (7%)

Query: 1618 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1677
            + DL IT  I +N + M++EHYN     +E L+  N VFT +F  E   K++A     +F
Sbjct: 718  FTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYF 777

Query: 1678 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1737
            +  WN  D  IV+LSLM + L  +          + + ++R  R+ RV KL K    +  
Sbjct: 778  QQGWNIFDSIIVILSLMELGLSRM----------SNLSVLRSFRLLRVFKLAKSWPTLNT 827

Query: 1738 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMA 1797
            L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      +   GL       +F  A
Sbjct: 828  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHA 887

Query: 1798 FLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVA 1857
            FL +FR+  G+ W   M D +    +          +L  + F+  +++   V++N+ +A
Sbjct: 888  FLIIFRILCGE-WIETMWDCMEVSGQ----------SLCLLVFLLVMVIGNLVVLNLFLA 936

Query: 1858 VLMKHLEESNKEAREDAELDAEIELEMAQ 1886
            +L+      N  A ++      ++L +A+
Sbjct: 937  LLLSSFSADNLTAPDEDREMNNLQLALAR 965



 Score =  108 bits (271), Expect = 5e-23
 Identities = 89/366 (24%), Positives = 159/366 (43%), Gaps = 79/366 (21%)

Query: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332
            ALY+ SP +  R +  K++ H +F+ +++  I  NCV +A   P   P  T+ V      
Sbjct: 110  ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP---PPWTKYV-----E 161

Query: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392
            Y FTAI+  E +VK++A G       +L+  WN LD  +++++ V   +          L
Sbjct: 162  YTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------L 212

Query: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452
            G L  LR  R LR L+ IS  PGLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 213  GNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272

Query: 1453 KGKF-----------------------------YYCEGPDT-------------RNISTK 1470
             G                                Y   P+               N S  
Sbjct: 273  MGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDA 332

Query: 1471 AQCRAAHYRWVRRKYN-------FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQP 1523
              C    YR ++   N       FD+   A ++LF L ++D W  +           QQ 
Sbjct: 333  GTCPEG-YRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLY----------QQT 381

Query: 1524 VQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRLRRL 1581
            +++     +++F+  + + SF+++N+ + VV   + +  Q    E EE  +R ++ +  L
Sbjct: 382  LRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEML 441

Query: 1582 ERRRRS 1587
            ++   +
Sbjct: 442  KKEHEA 447



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 103/400 (25%), Positives = 168/400 (42%), Gaps = 75/400 (18%)

Query: 88   RPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCN--ILEAFDAFIFA 145
            R R  C  +V + WFE   + +I+L+   L      ED+     +    +LE  D     
Sbjct: 1139 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1194

Query: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAI 198
             F +EM++K VA   +G K Y  + W  LDF IV       VA  + ++  G    + ++
Sbjct: 1195 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG---PIKSL 1248

Query: 199  RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258
            RT+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    
Sbjct: 1249 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-G 1307

Query: 259  RCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLG 318
            RC   +      N T +                     N   +C        L +   L 
Sbjct: 1308 RCINQTEGDLPLNYTIV---------------------NNKSQC------ESLNLTGELY 1340

Query: 319  WEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLE 378
            W    +   + VGA   A +    +                 + +I YA       +   
Sbjct: 1341 W-TKVKVNFDNVGAGYLALLQVATFK---------------GWMDIMYA------AVDSR 1378

Query: 379  GWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMRE 435
            G+ +   +  + + +  F+ F   II GSFF +NL + VI   F++ K++   +   M E
Sbjct: 1379 GYEEQPQWEYNLYMYIYFVIF---IIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE 1435

Query: 436  QRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRS 475
            ++ ++ +    L S          L KY G IF  V +++
Sbjct: 1436 EQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1475



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 75/289 (25%), Positives = 134/289 (46%), Gaps = 43/289 (14%)

Query: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833
            G++W         IV+  +F   I+  IL+++ ++  E  Y E+ + +   LE ++ +FT
Sbjct: 1134 GKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFT 1193

Query: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIV----GQAD-GGLSVLRTFRL 888
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V    G A+ G +  LRT R 
Sbjct: 1194 YVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRA 1253

Query: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS--LKTD 946
            LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  KF   +   
Sbjct: 1254 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQT 1313

Query: 947  TGD-----TVPDRK-------------------NFDSLLWAIVTVFQILTQEDWNVVLY- 981
             GD     T+ + K                   NFD++    + + Q+ T + W  ++Y 
Sbjct: 1314 EGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYA 1373

Query: 982  ----NGMASTSSW-----AALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
                 G      W       +YFV  + FG++   NL + ++++ F  +
Sbjct: 1374 AVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1422



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 75/289 (25%), Positives = 130/289 (44%), Gaps = 40/289 (13%)

Query: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841
            + G +  IV  + F   IM  I +N ++M VE  +Q  E  N L   N++F ++F  E +
Sbjct: 1463 YQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECI 1522

Query: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLR 890
            +KL A     Y  N +NIFD ++V++S   IVG     +            V+R  R+ R
Sbjct: 1523 VKLAALRHY-YFTNSWNIFDFVVVILS---IVGTVLSDIIQKYFFSPTLFRVIRLARIGR 1578

Query: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950
            +L+L+R    +R  L  L+ ++  +     LL L +FI+SI GM  F     +K + G  
Sbjct: 1579 ILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA---YVKWEAG-- 1633

Query: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL--------------------YNGMASTSSW 990
            + D  NF +   +++ +FQI T   W+ +L                      G   + + 
Sbjct: 1634 IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAV 1693

Query: 991  AALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039
              L+F   +     ++ N+ +AI++E F    + +     ED   + +E
Sbjct: 1694 GILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYE 1742



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 40/173 (23%), Positives = 89/173 (51%), Gaps = 21/173 (12%)

Query: 1603 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1662
            + P RR+   +      ++ I   I  N + M+ +H   P +     KY  Y FT ++ F
Sbjct: 117  FHPIRRAAVKILVHSLFNMLIMCTILTNCVFMA-QHDPPPWT-----KYVEYTFTAIYTF 170

Query: 1663 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1718
            E+ +K++A GF      F +D WN LD ++++++ +   ++   +SA           +R
Sbjct: 171  ESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSA-----------LR 219

Query: 1719 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771
              R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF
Sbjct: 220  TFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLF 272



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 8/157 (5%)

Query: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
           +V +P+ +    + I+LN     +F   E     SE   +L+  +      F  EM  K+
Sbjct: 713 VVMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKI 768

Query: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215
           +AL  +    Y    WN  D  IV+  +ME  L   + +LS +R+ R+LR  +     P+
Sbjct: 769 IALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPT 824

Query: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
           +  L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 825 LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 49/165 (29%), Positives = 76/165 (46%), Gaps = 15/165 (9%)

Query: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
            +V    F+   M +I LN VT+ +    E  +   E+ NIL   +    A F  E ++K+
Sbjct: 1470 IVTKQAFDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKL 1525

Query: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDG-------HNVSLSAIRTVRVLRPLR 208
             AL  +    Y  ++WN  DF +V+  ++   L                IR  R+ R LR
Sbjct: 1526 AALRHY----YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILR 1581

Query: 209  AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253
             I     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1582 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1626



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 28/97 (28%), Positives = 48/97 (49%), Gaps = 14/97 (14%)

Query: 1779 DNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPV 1838
            +NP  G   + +F +F  AFL LFR+ T D W  + + TLR   +           +  +
Sbjct: 346  ENPDHG---YTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGK-----------IYMI 391

Query: 1839 YFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAE 1875
            +F+  + +  F LVN+++AV+    EE N+    + E
Sbjct: 392  FFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETE 428



 Score = 32.7 bits (73), Expect = 4.3
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 366 YAWIAIFQVITLEGWVDIMYYVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 423
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943


>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
          Length = 1836

 Score =  437 bits (1125), Expect = e-122
 Identities = 320/1135 (28%), Positives = 554/1135 (48%), Gaps = 129/1135 (11%)

Query: 779  WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838
            W+ F   +  IV   +   GI + I++NTL M +E++   E   N L + N+VFT +F  
Sbjct: 564  WLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTA 623

Query: 839  EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898
            EM+LKL+A  P  Y +  +NIFD IIV +S+ E+      GLSVLR+FRLLRV KL +  
Sbjct: 624  EMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSW 683

Query: 899  PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFG-------CKFSLKTDTGDTV 951
            P L   + ++  ++  +     +L + +FIF+++GM LFG       CK +L     D  
Sbjct: 684  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIAL-----DCN 738

Query: 952  PDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAAL-YFVALMTFGNYVLFNLL 1010
              R +      + + VF+IL  E W   +++ M        L  F+ +M  GN V+ NL 
Sbjct: 739  LPRWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLF 797

Query: 1011 VAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRG 1070
            +A+L+  F A+  A  SD D +  ++           +   +L +        G L G+ 
Sbjct: 798  LALLLSSFSADSLA-ASDEDGEMNNLQIA--------IGRIKLGIGFAKAFLLGLLHGK- 847

Query: 1071 SLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCA 1130
             LSP  IM +        ++    + AP   D ++      +PP  D K    + +    
Sbjct: 848  ILSPKDIMLSLGEADGAGEAGEAGETAPE--DEKK------EPPEEDLKKDNHILNHMGL 899

Query: 1131 PWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTD--DEAEDGRAAPGP 1188
              GP    SS      +    P L  +      ES L    +  TD   E ED +  P P
Sbjct: 900  ADGPP---SSLELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQP 956

Query: 1189 RATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSED 1248
                                         DG      +  +   +   E+ AE + + E 
Sbjct: 957  LY---------------------------DGNSSVCSTADYKPPEEDPEEQAEENPEGE- 988

Query: 1249 SCCLRLHKVLEPYKPQWCRSR---EAW-ALYLFSPQNR------FRVSCQKVITHKMFDH 1298
                         +P+ C +    + W  LY+   Q R       R +C K++ H  F+ 
Sbjct: 989  -------------QPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFET 1035

Query: 1299 VVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHA 1358
             ++  I L+   +A E   I+     R  L  ++ +FT IF+ EM++K VA G       
Sbjct: 1036 FIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGF----KV 1091

Query: 1359 YLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKL 1418
            Y  ++W  LD L+V VS++ +V   A+  G   LG ++ LR LR LRPLR +SR  G+++
Sbjct: 1092 YFTNAWCWLDFLIVDVSIISLV---ANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRV 1148

Query: 1419 VVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC------EGPDTRNISTKAQ 1472
            VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYYC      E  D   ++ K++
Sbjct: 1149 VVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSE 1208

Query: 1473 CRA----AHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHN 1528
            C +       RW+  K N+DN+G   +SL  +++  GW++IMY  +D+   ++QP    N
Sbjct: 1209 CESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVN 1268

Query: 1529 PWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEA-RRREEKRLRRLERRRRS 1587
             +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++     E+K+     ++  S
Sbjct: 1269 LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGS 1328

Query: 1588 TFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDE 1647
              P     ++P     +  +  ++ L T    D+ I  +IC+N++TM +E  NQ +   +
Sbjct: 1329 KKP-----QKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVD 1383

Query: 1648 ALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAAL 1707
             L   N +F I+F  E  LK++A   + +F   WN  D  +V+LS++G+ L ++      
Sbjct: 1384 ILYNINMIFIIIFTGECVLKMLALR-QYYFTVGWNIFDFVVVILSIVGLALSDLIQKYF- 1441

Query: 1708 PINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALG 1767
             ++PT+ R++R+ RI RVL+L++ A G+R LL  ++ +LP + N+GLL  L+ FIY+  G
Sbjct: 1442 -VSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFG 1500

Query: 1768 VELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLR----ECSR 1823
            +  F  ++        G+     F  FG + + LF ++T   W+G++   L     +C  
Sbjct: 1501 MSNFAYVKKE-----SGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDP 1555

Query: 1824 EDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEARE 1872
              ++  + +      P++   +F ++++++  ++VN+ +A+++++   + +E+ E
Sbjct: 1556 NLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSE 1610



 Score =  116 bits (291), Expect = 2e-25
 Identities = 100/390 (25%), Positives = 180/390 (46%), Gaps = 43/390 (11%)

Query: 76  AATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNI 135
           A    + L   +  R   ++++ +  F    M+ I+ NCV + M  P    +      N+
Sbjct: 107 ATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSK------NV 160

Query: 136 LEAFDAFIFAFFAVEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVS 194
              F       +  E +IK++A G       +L D WN LDF +++   +   +D  N+S
Sbjct: 161 EYTFTGI----YTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNIS 216

Query: 195 LSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254
             A+RT RVLR L+ I  +P ++ +V  L+ ++  L +V++L  F   +F +VG+QL+ G
Sbjct: 217 --ALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274

Query: 255 LLRNRCFLDSAFVRNNNLTFLR--PYY--QTEEGEENPFICSSRRDNGMQKCSHIPGRRE 310
            LR +C        + N T+     +Y   T  G E  +   S   N     SH      
Sbjct: 275 NLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWN-SHASWATN 333

Query: 311 LRMPCTLGWEAYTQPQAE--GVGAARNACINWN--------QYYNVCRSGDSNPHNGAIN 360
                T  W+AY   +     +  + +A +  N        + Y   ++G  NP+ G  +
Sbjct: 334 ----DTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTG-RNPNYGYTS 388

Query: 361 FDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 420
           +D   +A++A+F+++T + W ++    + A      I+F+++I +GSF++INL L V+A 
Sbjct: 389 YDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAM 448

Query: 421 QFSE----------TKQRESQLMREQRARH 440
            ++E           K+ E Q M E+  +H
Sbjct: 449 AYAEQNEATLAEDKEKEEEFQQMLEKFKKH 478



 Score =  106 bits (265), Expect = 2e-22
 Identities = 76/273 (27%), Positives = 131/273 (47%), Gaps = 28/273 (10%)

Query: 1610 IHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLV 1669
            IH +    ++DL IT  I +N + M+MEHY   +  D  L   N VFT +F  E  LKL+
Sbjct: 571  IHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLI 630

Query: 1670 AFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLL 1729
            A     +F+  WN  D  IV LSL+ + L  ++           + ++R  R+ RV KL 
Sbjct: 631  AMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQG----------LSVLRSFRLLRVFKLA 680

Query: 1730 KMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR----LECSEDNPCEGL 1785
            K    +  L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      C     C   
Sbjct: 681  KSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLP 740

Query: 1786 SRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVL 1845
              H    +F  +FL +FR+  G+ W   M D +    +          A+    F+  ++
Sbjct: 741  RWH--MHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQ----------AMCLTVFLMVMV 787

Query: 1846 VAQFVLVNVVVAVLMKHLE-ESNKEAREDAELD 1877
            +   V++N+ +A+L+     +S   + ED E++
Sbjct: 788  IGNLVVLNLFLALLLSSFSADSLAASDEDGEMN 820



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 78/250 (31%), Positives = 114/250 (45%), Gaps = 33/250 (13%)

Query: 28   ASPESPGAPGREAERGSELGVSPSESPAAERGAELGADEEQRVPYPALAAT--------- 78
            + PE    P +    G+    S ++    E   E  A+E      P    T         
Sbjct: 945  SEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPC 1004

Query: 79   VFFCLGQTTRPRSWCLRLVC-----NPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC 133
            ++  + Q    + W LR  C     + WFE   + +I+L+   L      ED+     R 
Sbjct: 1005 LYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRRV 1060

Query: 134  --NILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMM 184
               ILE  D      F +EM++K VA   +G K Y  + W  LDF IV       VA  +
Sbjct: 1061 IRTILEYADKVFTYIFIMEMLLKWVA---YGFKVYFTNAWCWLDFLIVDVSIISLVANWL 1117

Query: 185  EYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIF 244
             YS  G    + ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF
Sbjct: 1118 GYSELG---PIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIF 1174

Query: 245  GIVGVQLWAG 254
             I+GV L+AG
Sbjct: 1175 SIMGVNLFAG 1184



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 55/182 (30%), Positives = 95/182 (52%), Gaps = 17/182 (9%)

Query: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332
            ALYL SP +  R    KV+ H +F   +++ I  NCV + +  P   P  ++ V      
Sbjct: 110  ALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDP---PPWSKNV-----E 161

Query: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392
            Y FT I+  E ++K++A G    +  +L+  WN LD  +++++ +   V          L
Sbjct: 162  YTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD---------L 212

Query: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452
            G +  LR  R LR L+ I+  PGLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 213  GNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLF 272

Query: 1453 KG 1454
             G
Sbjct: 273  MG 274



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 82/329 (24%), Positives = 150/329 (45%), Gaps = 53/329 (16%)

Query: 1233 DSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALY-LFSPQNRFRVSCQKVI 1291
            DS   DA E  +++   C            P W +      ++   +P  +F+     ++
Sbjct: 527  DSGISDAMEELEEAHQKC-----------PPWWYKCAHKVLIWNCCAPWLKFKNIIHLIV 575

Query: 1292 THKMFDHVVLVFIFLNCVTIALERPDIDPGSTERV--FLSVSNYIFTAIFVAEMMVKVVA 1349
                 D  + + I LN + +A+E   +    TE     L+V N +FT IF AEM++K++A
Sbjct: 576  MDPFVDLGITICIVLNTLFMAMEHYPM----TEHFDNVLTVGNLVFTGIFTAEMVLKLIA 631

Query: 1350 LGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRV 1409
            +      + Y Q  WN+ D ++V +SLV++       G A + G L VLR  R LR  ++
Sbjct: 632  MD----PYEYFQQGWNIFDSIIVTLSLVEL-------GLANVQG-LSVLRSFRLLRVFKL 679

Query: 1410 ISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIST 1469
                P L ++++ + +S+  +GN+ L+      IF ++G+QLF GK Y            
Sbjct: 680  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY-----------K 727

Query: 1470 KAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNP 1529
            +  C+ A    + R +  D     L+   +L  +  W+  M+D ++  G           
Sbjct: 728  ECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGE--WIETMWDCMEVAG---------QA 776

Query: 1530 WMLLYFISFLLIVSFFVLNMFVGVVVENF 1558
              L  F+  ++I +  VLN+F+ +++ +F
Sbjct: 777  MCLTVFLMVMVIGNLVVLNLFLALLLSSF 805



 Score = 93.2 bits (230), Expect = 3e-18
 Identities = 99/449 (22%), Positives = 180/449 (40%), Gaps = 71/449 (15%)

Query: 638  GGPPGTGGHGPLSLNSPDPYEKIP---------HVVGEHGLGQAP------GHLSGLSVP 682
            G   G G  G     +P+  +K P         H++   GL   P       HL+ ++ P
Sbjct: 859  GEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNP 918

Query: 683  CPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEFTQDV-RHGDRWD 741
                  P  +   +L+         E+     S  E      + +Y+    V    D   
Sbjct: 919  YLTIQVPIASEESDLEM------PTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKP 972

Query: 742  PTRPPRATDTPGPGPGSPQRRAQQRAAPGEP-------GWMGRLWVTFSGKLRRIVDSKY 794
            P   P       P    P+    +      P          G+ W T      +IV+  +
Sbjct: 973  PEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNW 1032

Query: 795  FSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGY 852
            F   I+  IL+++ ++  E  Y EQ   +   LE ++ VFT +F +EMLLK +A G   Y
Sbjct: 1033 FETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVY 1092

Query: 853  IRNPYNIFDGIIVVISVWEIV----GQAD-GGLSVLRTFRLLRVLKLVRFLPALRRQLVV 907
              N +   D +IV +S+  +V    G ++ G +  LRT R LR L+ +     +R  +  
Sbjct: 1093 FTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNA 1152

Query: 908  LVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKF--SLKTDTGDT--------------- 950
            L+  + ++     + ++F  IFSI+G++LF  KF   + T T +                
Sbjct: 1153 LLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESL 1212

Query: 951  --------VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAS----------TSSWAA 992
                    +  + N+D++    +++ Q+ T + W  ++Y  + S           + +  
Sbjct: 1213 MHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMY 1272

Query: 993  LYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
            LYFV  + FG++   NL + ++++ F  +
Sbjct: 1273 LYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1301



 Score = 85.5 bits (210), Expect = 6e-16
 Identities = 75/288 (26%), Positives = 130/288 (45%), Gaps = 41/288 (14%)

Query: 784  GKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLK 843
            G +  +V  + F   IM+ I +N ++M VE   Q +   + L   N++F  +F  E +LK
Sbjct: 1344 GMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLK 1403

Query: 844  LLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLRVL 892
            +LA     Y    +NIFD ++V++S   IVG A   L            V+R  R+ RVL
Sbjct: 1404 MLALRQY-YFTVGWNIFDFVVVILS---IVGLALSDLIQKYFVSPTLFRVIRLARIGRVL 1459

Query: 893  KLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVP 952
            +L+R    +R  L  L+ ++  +     LL L +FI+SI GM  F     +K ++G  + 
Sbjct: 1460 RLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA---YVKKESG--ID 1514

Query: 953  DRKNFDSLLWAIVTVFQILTQEDWNVVL---------------------YNGMASTSSWA 991
            D  NF++   +I+ +F+I T   W+ +L                       G     S  
Sbjct: 1515 DMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIG 1574

Query: 992  ALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039
              +F + +     ++ N+ +AI++E F    + +     ED   + +E
Sbjct: 1575 ICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYE 1622



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 36/124 (29%), Positives = 69/124 (55%), Gaps = 13/124 (10%)

Query: 339  NWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAH------- 391
            N ++  ++  +G     N  +N+DN+G  ++++ QV T +GW+DIMY  +D+        
Sbjct: 1205 NKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQ 1264

Query: 392  ---SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDS 445
               + Y ++YF++ II GSFF +NL + VI   F++ K++   +   M E++ ++ +   
Sbjct: 1265 YEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMK 1324

Query: 446  TLAS 449
             L S
Sbjct: 1325 KLGS 1328



 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 46/166 (27%), Positives = 81/166 (48%), Gaps = 15/166 (9%)

Query: 98  CNPW--FEHVSMLVIMLNCVTLG---------MFRPCEDVECGSERCNILEAFDAFIFAF 146
           C PW  F+++  L++M   V LG         +F   E         N+L   +      
Sbjct: 561 CAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGI 620

Query: 147 FAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRP 206
           F  EMV+K++A+  +    Y    WN  D  IV   ++E  L  +   LS +R+ R+LR 
Sbjct: 621 FTAEMVLKLIAMDPYE---YFQQGWNIFDSIIVTLSLVELGL-ANVQGLSVLRSFRLLRV 676

Query: 207 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
            +     P++ +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 677 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 722



 Score = 65.1 bits (157), Expect = 8e-10
 Identities = 44/148 (29%), Positives = 81/148 (54%), Gaps = 13/148 (8%)

Query: 795 FSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG----PL 850
           FS  IM+ IL N + M +     P   +  +E +   FT ++  E L+K+LA G      
Sbjct: 133 FSMFIMITILTNCVFMTMS---DPPPWSKNVEYT---FTGIYTFESLIKILARGFCVDDF 186

Query: 851 GYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLV 909
            ++R+P+N  D  +I++  + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 187 TFLRDPWNWLDFSVIMMAYLTEFVDL--GNISALRTFRVLRALKTITVIPGLKTIVGALI 244

Query: 910 KTMDNVATFCTLLMLFIFIFSILGMHLF 937
           +++  ++    L +  + +F+++G+ LF
Sbjct: 245 QSVKKLSDVMILTVFCLSVFALVGLQLF 272



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 41/173 (23%), Positives = 86/173 (49%), Gaps = 21/173 (12%)

Query: 1603 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1662
            +S  RR    +       +FI   I  N + M+M     P S     K   Y FT ++ F
Sbjct: 117  FSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSD-PPPWS-----KNVEYTFTGIYTF 170

Query: 1663 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1718
            E+ +K++A GF      F +D WN LD ++++++ +   ++   +SA           +R
Sbjct: 171  ESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISA-----------LR 219

Query: 1719 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771
              R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF
Sbjct: 220  TFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLF 272



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 51/165 (30%), Positives = 78/165 (47%), Gaps = 15/165 (9%)

Query: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
            LV    F+   M++I LN VT+ +    E       + +IL   +      F  E V+KM
Sbjct: 1349 LVTKQAFDITIMILICLNMVTMMV----ETDNQSQLKVDILYNINMIFIIIFTGECVLKM 1404

Query: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDG----HNVS---LSAIRTVRVLRPLR 208
            +AL    ++ Y    WN  DF +V+  ++  +L      + VS      IR  R+ R LR
Sbjct: 1405 LAL----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLR 1460

Query: 209  AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253
             I     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1461 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA 1505



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 35/177 (19%), Positives = 73/177 (41%), Gaps = 17/177 (9%)

Query: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015
            ++D+  WA + +F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 388  SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVA 447

Query: 1016 EGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPP 1075
              +  + +A  ++  E +    F++   K ++ Q    K  +      G  +G       
Sbjct: 448  MAYAEQNEATLAEDKEKEE--EFQQMLEKFKKHQEELEKAKAAQALEGGEADG------- 498

Query: 1076 LIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPW 1132
                    P      +  LD +     + R  SSSGD  + D           C PW
Sbjct: 499  -------DPAHGKDCNGSLDTSQGEKGAPR-QSSSGDSGISDAMEELEEAHQKCPPW 547



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 39/134 (29%), Positives = 63/134 (47%), Gaps = 27/134 (20%)

Query: 1780 NPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVY 1839
            NP  G + + TFS    AFL LFR+ T D W  + + TLR   +      +Y+     ++
Sbjct: 381  NPNYGYTSYDTFS---WAFLALFRLMTQDYWENLFQLTLRAAGK------TYM-----IF 426

Query: 1840 FVTFVLVAQFVLVNVVVAVL-MKHLEESNKEAREDAELDAEI------------ELEMAQ 1886
            FV  + +  F L+N+++AV+ M + E++     ED E + E             ELE A+
Sbjct: 427  FVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAK 486

Query: 1887 GPGSARRVDADRPP 1900
               +    +AD  P
Sbjct: 487  AAQALEGGEADGDP 500



 Score = 41.6 bits (96), Expect = 0.009
 Identities = 31/134 (23%), Positives = 58/134 (43%), Gaps = 22/134 (16%)

Query: 1453 KGKFYYCEGPDTR----NISTKAQCRAAHYRWVRRKYN-------FDNLGQALMSLFVLS 1501
            +G FY+ EG +      N S    C    Y  ++   N       +D    A ++LF L 
Sbjct: 345  EGNFYFLEGSNDALLCGNSSDAGHCPEG-YECIKTGRNPNYGYTSYDTFSWAFLALFRLM 403

Query: 1502 SKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKC 1561
            ++D W N+    L A G             +++F+  + + SF+++N+ + VV   + + 
Sbjct: 404  TQDYWENLFQLTLRAAGKTY----------MIFFVVIIFLGSFYLINLILAVVAMAYAEQ 453

Query: 1562 RQHQEAEEARRREE 1575
             +   AE+  + EE
Sbjct: 454  NEATLAEDKEKEEE 467


>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
            sapiens]
          Length = 1956

 Score =  419 bits (1076), Expect = e-116
 Identities = 306/1162 (26%), Positives = 532/1162 (45%), Gaps = 134/1162 (11%)

Query: 778  LWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFA 837
            +WV     L  +V   +    I + I+VNT+ M +E+H         L+I NIVFT  F 
Sbjct: 650  MWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFT 709

Query: 838  LEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRF 897
             EM+ K++A  P  Y +  +NIFD IIV +S+ E+     G LSVLR+FRLLRV KL + 
Sbjct: 710  AEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKS 769

Query: 898  LPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPD---R 954
             P L   + ++  ++  +     +L + +F+F+++G  L G  +           +   R
Sbjct: 770  WPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPR 829

Query: 955  KNFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAI 1013
             +      + + VF+IL  E W   ++  M     S   + F+ +M  GN V+ NL +A+
Sbjct: 830  WHMHDFFHSFLIVFRILCGE-WIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIAL 888

Query: 1014 LVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLS 1073
            L+  F A+      D  E                     L++    +   GH   +   S
Sbjct: 889  LLNSFSADNLTAPEDDGE------------------VNNLQVALARIQVFGHRTKQALCS 930

Query: 1074 PPLIMCTAATPMPTPKSSPFLDAAPSLPDSR----------RGSSSSGDPPLGDQKPPAS 1123
                  + + P P PK+ P L     L  S+          RGSS     P G +   + 
Sbjct: 931  ----FFSRSCPFPQPKAEPELVVKLPLSSSKAENHIAANTARGSSGGLQAPRGPRDEHSD 986

Query: 1124 LRSSPCAPW------------------GPSGAWSSRRSSWSSLGRAPSLKRRGQCGERES 1165
              ++P   W                  G   A S ++      G+   L++  +CG+  +
Sbjct: 987  FIANPTV-WVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPK-GQQEQLQQVERCGDHLT 1044

Query: 1166 LLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALP 1225
              S     S++D A          + P   AE +D       +     C D        P
Sbjct: 1045 PRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGST--VDCLD--------P 1094

Query: 1226 SDFFLRIDSHREDAAELDDDSEDSC-----CLRLHKVLEPYKPQWCRSREAWALYLFSPQ 1280
             +   +I    +D  E DD   + C     C +L     P+   W               
Sbjct: 1095 EEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGW--------------- 1139

Query: 1281 NRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFV 1340
             + R +C +++ H  F+  ++  I L+  ++A E   +D   T +  L  ++ +FT IFV
Sbjct: 1140 -QVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFV 1198

Query: 1341 AEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRL 1400
             EM++K VA G       Y  ++W  LD L+V +SL+ +   +        +  ++ LR 
Sbjct: 1199 FEMLLKWVAYGFKK----YFTNAWCWLDFLIVNISLISLTAKILEYSE---VAPIKALRT 1251

Query: 1401 LRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCE 1460
            LR LRPLR +SR  G+++VV+ L+ ++  I N++L+C  F++IF I+GV LF GKF+ C 
Sbjct: 1252 LRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCI 1311

Query: 1461 GPDTRNIS--------TKAQCRAAH----YRWVRRKYNFDNLGQALMSLFVLSSKDGWVN 1508
                   S         K+ C+  +    + WV  K NFDN+    ++L  +++  GW++
Sbjct: 1312 NYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMD 1371

Query: 1509 IMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAE 1568
            IMY  +D+  V+ QP    N +M LYF+ F++   FF LN+FVGV+++NF++ ++    +
Sbjct: 1372 IMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQ 1431

Query: 1569 EA-RRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFII 1627
            +     E+K+     ++  S  P     ++P     +  +  +  + T    D+ I  +I
Sbjct: 1432 DIFMTEEQKKYYNAMKKLGSKKP-----QKPIPRPLNKFQGFVFDIVTRQAFDITIMVLI 1486

Query: 1628 CVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLA 1687
            C+N+ITM +E  +Q +   + L   N  F  VF  E  +K+ A   + +F + WN  D  
Sbjct: 1487 CLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR-QYYFTNGWNVFDFI 1545

Query: 1688 IVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALP 1747
            +V+LS+  +    I  S     +PT+ R++R+ RI R+L+L++ A G+R LL  ++ +LP
Sbjct: 1546 VVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLP 1605

Query: 1748 QVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTG 1807
             + N+GLL  L+ FIY+  G+  F  +         G+     F  F  + L LF+++T 
Sbjct: 1606 ALFNIGLLLFLVMFIYSIFGMSSFPHVRWE-----AGIDDMFNFQTFANSMLCLFQITTS 1660

Query: 1808 DNWNGIMKDTLRECSREDKHCLSYL------------PALSPVYFVTFVLVAQFVLVNVV 1855
              W+G++   L   +    +C   L            PA+  ++F T+++++  ++VN+ 
Sbjct: 1661 AGWDGLLSPIL---NTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMY 1717

Query: 1856 VAVLMKHLEESNKEAREDAELD 1877
            +AV++++   + +E+ E    D
Sbjct: 1718 IAVILENFNVATEESTEPLSED 1739



 Score =  146 bits (369), Expect = 2e-34
 Identities = 195/859 (22%), Positives = 348/859 (40%), Gaps = 190/859 (22%)

Query: 794  YFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG----P 849
            +FS  I + ILVN + M           T+  E    VFT ++  E L+K+LA G     
Sbjct: 131  WFSLFITVTILVNCVCM---------TRTDLPEKIEYVFTVIYTFEALIKILARGFCLNE 181

Query: 850  LGYIRNPYNIFDGIIVVISVWEIVGQADG--GLSVLRTFRLLRVLKLVRFLPALRRQLVV 907
              Y+R+P+N  D  ++ ++    VG A    G+S LRTFR+LR LK V  +P L+  +  
Sbjct: 182  FTYLRDPWNWLDFSVITLAY---VGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGA 238

Query: 908  LVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGD-TVPDRKNF--------- 957
            L+ ++  +A    L +  + +F+++G+ LF      K    D  V +  N+         
Sbjct: 239  LIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIY 298

Query: 958  -----------------------------------------DSLLWAIVTVFQILTQEDW 976
                                                     DS  WA +++F+++TQ+ W
Sbjct: 299  INKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSW 358

Query: 977  NVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDE-DKTS 1035
              +    + ++     ++FV ++  G++ L NL++A++   ++   + N++ TDE +   
Sbjct: 359  ERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYE---EQNQATTDEIEAKE 415

Query: 1036 VHFEEDFHKLRE---------LQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMP 1086
              F+E    LR+         + TT L   + +   + +   R     P +   +     
Sbjct: 416  KKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTEDNK 475

Query: 1087 TPKSSP-------FLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWS 1139
            +P+S P       FL  A     +  GS      P  D   P  +      P    G   
Sbjct: 476  SPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFP----GDHE 531

Query: 1140 SRRSS---------WSSLGRAPSLK------RRGQCGERESLLSGEGKGSTDDEAEDGRA 1184
            S R S            L R+P  +      R G+   +    S    G+ D  A D   
Sbjct: 532  SHRGSLLLGGGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDA-- 589

Query: 1185 APGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDD 1244
              G + T L  AE LD  P R           R   VV++       I S  E+     +
Sbjct: 590  --GQKKTFL-SAEYLD-EPFR---------AQRAMSVVSI-------ITSVLEEL----E 625

Query: 1245 DSEDSCCLRLHKVLEPYK-----PQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHV 1299
            +SE  C   L  + + Y      P W + +      LF            ++T    +  
Sbjct: 626  ESEQKCPPCLTSLSQKYLIWDCCPMWVKLK----TILFG-----------LVTDPFAELT 670

Query: 1300 VLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAY 1359
            + + I +N + +A+E   + P  T    L + N +FT  F AEM+ K++A       + Y
Sbjct: 671  ITLCIVVNTIFMAMEHHGMSP--TFEAMLQIGNIVFTIFFTAEMVFKIIAF----DPYYY 724

Query: 1360 LQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLV 1419
             Q  WN+ D ++V VSL+++ VA          G L VLR  R LR  ++    P L  +
Sbjct: 725  FQKKWNIFDCIIVTVSLLELGVAKK--------GSLSVLRSFRLLRVFKLAKSWPTLNTL 776

Query: 1420 VETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYR 1479
            ++ + +S+  +GN+ +I      +F ++G QL         G + RN   +    A H  
Sbjct: 777  IKIIGNSVGALGNLTIILAIIVFVFALVGKQLL--------GENYRN--NRKNISAPHED 826

Query: 1480 WVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFL 1539
            W R  ++  +   + + +F +   + W+  M+  ++   V Q+ +       L+ F++ +
Sbjct: 827  WPR--WHMHDFFHSFLIVFRILCGE-WIENMWACME---VGQKSI------CLILFLTVM 874

Query: 1540 LIVSFFVLNMFVGVVVENF 1558
            ++ +  VLN+F+ +++ +F
Sbjct: 875  VLGNLVVLNLFIALLLNSF 893



 Score =  125 bits (313), Expect = 6e-28
 Identities = 81/342 (23%), Positives = 155/342 (45%), Gaps = 60/342 (17%)

Query: 90  RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAV 149
           R   +++  + WF     + I++NCV +              R ++ E  +      +  
Sbjct: 120 RRTAIKVSVHSWFSLFITVTILVNCVCM-------------TRTDLPEKIEYVFTVIYTF 166

Query: 150 EMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLR 208
           E +IK++A G    +  YL D WN LDF ++    +  ++D   +S   +RT RVLR L+
Sbjct: 167 EALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGIS--GLRTFRVLRALK 224

Query: 209 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFVR 268
            ++ +P ++++V  L+ ++  L +V +L  F   +F +VG+QL+ G L+N+C  +   V 
Sbjct: 225 TVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVN 284

Query: 269 --NNNLTFLRP-YYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYTQP 325
              N  +  +P  Y  + G  +P +C +  D+G     H P             + Y   
Sbjct: 285 ETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSG-----HCP-------------DGY--- 323

Query: 326 QAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMY 385
                               +C     NP     +FD+  +A++++F+++T + W  +  
Sbjct: 324 --------------------ICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQ 363

Query: 386 YVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQ 427
             +        I+F+L+I +GSF+++NL L V+   + E  Q
Sbjct: 364 QTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQ 405



 Score =  113 bits (282), Expect = 3e-24
 Identities = 91/350 (26%), Positives = 155/350 (44%), Gaps = 67/350 (19%)

Query: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332
            AL+LFSP N  R +  KV  H  F   + V I +NCV   + R D+     E++      
Sbjct: 109  ALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCV--CMTRTDLP----EKI-----E 157

Query: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392
            Y+FT I+  E ++K++A G    E  YL+  WN LD  ++ ++ V   + +    G    
Sbjct: 158  YVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---- 213

Query: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452
                 LR  R LR L+ +S  PGLK++V  LI S++ + ++ ++      +F ++G+QLF
Sbjct: 214  -----LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLF 268

Query: 1453 KG-----------------KFYYCEGPD----TRNISTKAQC----RAAH----YRWVRR 1483
            KG                  +     PD     R  S    C     + H    Y  ++ 
Sbjct: 269  KGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKT 328

Query: 1484 KYN-------FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFI 1536
              N       FD+   A +SLF L ++D W  +           QQ ++      +++F+
Sbjct: 329  SDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLY----------QQTLRTSGKIYMIFFV 378

Query: 1537 SFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR 1586
              + + SF+++N+ + VV   + +  Q    +E   +E+K    LE  R+
Sbjct: 379  LVIFLGSFYLVNLILAVVTMAYEEQNQ-ATTDEIEAKEKKFQEALEMLRK 427



 Score = 98.2 bits (243), Expect = 8e-20
 Identities = 72/331 (21%), Positives = 147/331 (44%), Gaps = 86/331 (25%)

Query: 1600 YADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIV 1659
            ++ ++  RR+   +    +  LFIT  I VN + M+    + P+ ++       YVFT++
Sbjct: 113  FSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRT--DLPEKIE-------YVFTVI 163

Query: 1660 FVFEAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIR 1715
            + FEA +K++A GF      + +D WN LD +++ L+ +G  ++   +S           
Sbjct: 164  YTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISG---------- 213

Query: 1716 IMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GRL 1774
             +R  R+ R LK + +  G++ ++  ++ ++ ++ ++ +L +    ++A +G++LF G L
Sbjct: 214  -LRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNL 272

Query: 1775 E---------------------------------------------CSEDNPCEGLS--- 1786
            +                                             C +   C   S   
Sbjct: 273  KNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNP 332

Query: 1787 --RHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFV 1844
               + +F +F  AFL+LFR+ T D+W  + + TLR   +           +  ++FV  +
Sbjct: 333  DFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGK-----------IYMIFFVLVI 381

Query: 1845 LVAQFVLVNVVVAVLMKHLEESNKEAREDAE 1875
             +  F LVN+++AV+    EE N+   ++ E
Sbjct: 382  FLGSFYLVNLILAVVTMAYEEQNQATTDEIE 412



 Score = 92.8 bits (229), Expect = 4e-18
 Identities = 63/174 (36%), Positives = 92/174 (52%), Gaps = 19/174 (10%)

Query: 90   RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFF 147
            R  C R+V + WFE   + +I+L+  +L      ED     +     +LE  D      F
Sbjct: 1142 RKTCYRIVEHSWFESFIIFMILLSSGSLAF----EDYYLDQKPTVKALLEYTDRVFTFIF 1197

Query: 148  AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAIRT 200
              EM++K VA   +G K Y  + W  LDF IV        A ++EYS       + A+RT
Sbjct: 1198 VFEMLLKWVA---YGFKKYFTNAWCWLDFLIVNISLISLTAKILEYS---EVAPIKALRT 1251

Query: 201  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 1252 LRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1305



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 72/288 (25%), Positives = 130/288 (45%), Gaps = 36/288 (12%)

Query: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841
            F G +  IV  + F   IM+ I +N ++M VE  +Q EE T  L   N  F ++F  E +
Sbjct: 1465 FQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECV 1524

Query: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA----------DGGLSVLRTFRLLRV 891
            +K+ A     Y  N +N+FD I+VV+S+  ++  A               V+R  R+ R+
Sbjct: 1525 MKMFALRQY-YFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRI 1583

Query: 892  LKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTV 951
            L+L+R    +R  L  L+ ++  +     LL L +FI+SI GM  F     ++ + G  +
Sbjct: 1584 LRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFP---HVRWEAG--I 1638

Query: 952  PDRKNFDSLLWAIVTVFQILTQEDWNVVL--------------------YNGMASTSSWA 991
             D  NF +   +++ +FQI T   W+ +L                      G   + +  
Sbjct: 1639 DDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVG 1698

Query: 992  ALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039
             ++F   +     ++ N+ +A+++E F    + +     ED   + +E
Sbjct: 1699 IIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYE 1746



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 76/298 (25%), Positives = 131/298 (43%), Gaps = 50/298 (16%)

Query: 768  APGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNAL 825
            +P + GW  R          RIV+  +F   I+  IL+++ S+  E  Y +Q   +   L
Sbjct: 1133 SPWDVGWQVRK------TCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALL 1186

Query: 826  EISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA-----DGGL 880
            E ++ VFT +F  EMLLK +A G   Y  N +   D +IV IS+  +  +         +
Sbjct: 1187 EYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPI 1246

Query: 881  SVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCK 940
              LRT R LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  K
Sbjct: 1247 KALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1306

Query: 941  F-------------------------SLKTDTGD--TVPDRKNFDSLLWAIVTVFQILTQ 973
            F                          ++  TG    V  + NFD++    + + Q+ T 
Sbjct: 1307 FWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATF 1366

Query: 974  EDWNVVLYNGMAS----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
            + W  ++Y  + S           + +  LYFV  + FG +   NL V ++++ F  +
Sbjct: 1367 KGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQ 1424



 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 40/133 (30%), Positives = 70/133 (52%), Gaps = 13/133 (9%)

Query: 356  NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAH----------SFYNFIYFILLIIV 405
            N  +NFDN+   ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II 
Sbjct: 1345 NVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIF 1404

Query: 406  GSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDSTLASFSEPGSCYEELLK 462
            G FF +NL + VI   F++ K++   +   M E++ ++ +    L S          L K
Sbjct: 1405 GGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1464

Query: 463  YVGHIFRKVKRRS 475
            + G +F  V R++
Sbjct: 1465 FQGFVFDIVTRQA 1477



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 51/163 (31%), Positives = 76/163 (46%), Gaps = 17/163 (10%)

Query: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
            +V    F+   M++I LN +T+ +    E  +   E+  IL   + F  A F  E V+KM
Sbjct: 1472 IVTRQAFDITIMVLICLNMITMMV----ETDDQSEEKTKILGKINQFFVAVFTGECVMKM 1527

Query: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSA---------IRTVRVLRP 206
             AL    ++ Y  + WN  DF +VV  +          SL +         IR  R+ R 
Sbjct: 1528 FAL----RQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRI 1583

Query: 207  LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGV 249
            LR I     +R L+  L+ +LP L N+ LL F V FI+ I G+
Sbjct: 1584 LRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM 1626



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 52/206 (25%), Positives = 92/206 (44%), Gaps = 28/206 (13%)

Query: 65  DEEQRVPYPALAAT-----VFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGM 119
           + EQ+ P P L +      ++ C     + ++    LV +P+ E    L I++N + + M
Sbjct: 626 ESEQKCP-PCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAM 684

Query: 120 FRPCEDVECGSERCNILEAFDAFI-------FAFFAVEMVIKMVALGLFGQKCYLGDTWN 172
                      E   +   F+A +         FF  EMV K++A   F    Y    WN
Sbjct: 685 -----------EHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA---FDPYYYFQKKWN 730

Query: 173 RLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGN 232
             D  IV   ++E  +     SLS +R+ R+LR  +     P++  L+ ++ +++  LGN
Sbjct: 731 IFDCIIVTVSLLELGV-AKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGN 789

Query: 233 VLLLCFFVFFIFGIVGVQLWAGLLRN 258
           + ++   + F+F +VG QL     RN
Sbjct: 790 LTIILAIIVFVFALVGKQLLGENYRN 815


>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
            sapiens]
          Length = 1791

 Score =  349 bits (895), Expect = 2e-95
 Identities = 187/598 (31%), Positives = 340/598 (56%), Gaps = 36/598 (6%)

Query: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343
            R +C +++ H  F+  ++  I L+   +  E   ++     +  L+ ++ IFT IF+ EM
Sbjct: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEM 1105

Query: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403
            ++K VA G       Y  S+W  LD ++V+VS+  ++  M           L+  R LR 
Sbjct: 1106 VLKWVAFGF----GKYFTSAWCCLDFIIVIVSVTTLINLME----------LKSFRTLRA 1151

Query: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC-EGP 1462
            LRPLR +S+  G+K+VV  LI ++  I N++L+C  F+++F ILGV  F GKF  C  G 
Sbjct: 1152 LRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCINGT 1211

Query: 1463 DT----RNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518
            D+      I+ K+QC + ++ W+ +K NFDN+G A ++L  +++  GW++I+Y  +D+  
Sbjct: 1212 DSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTE 1271

Query: 1519 VDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEA-RRREEKR 1577
             +QQP    N    +YF+ F++  SFF LN+F+GV+++NF++ ++    ++     E+K+
Sbjct: 1272 KEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKK 1331

Query: 1578 LRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSME 1637
                 ++  S  P     ++P     +  +  +  + TS   D+ I  +I +N+I+M  E
Sbjct: 1332 YYNAMKKLGSKKP-----QKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAE 1386

Query: 1638 HYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGIT 1697
             YNQPK++   L + N+VF ++F  E  +K+ A   + +F + WN  D  +VLLS++   
Sbjct: 1387 SYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFDCVVVLLSIVSTM 1445

Query: 1698 LEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFM 1757
            +  +E    +P  PT+ RI+R+ RI R+L+L++ A G+R LL  ++ +LP + N+GLL  
Sbjct: 1446 ISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLF 1505

Query: 1758 LLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDT 1817
            L+ FIYA LG+  F ++     NP  G+     F  F  + L LF++ST   W+ ++   
Sbjct: 1506 LIMFIYAILGMNWFSKV-----NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPM 1560

Query: 1818 LR---ECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEARE 1872
            LR    C+   ++C  +LP ++  YFV++++++  ++VN+ +AV++++   + +E+ +
Sbjct: 1561 LRSKESCNSSSENC--HLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1616



 Score =  128 bits (321), Expect = 8e-29
 Identities = 81/276 (29%), Positives = 139/276 (50%), Gaps = 14/276 (5%)

Query: 779  WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838
            W+     LR ++   +    I + I++NT+ + +E+H+        L I N+VFTS+F  
Sbjct: 563  WLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIA 622

Query: 839  EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVG--QADGGLSVLRTFRLLRVLKLVR 896
            EM LK++A  P  Y R  +NIFD I+ ++S  +++           LR+FR+LRV KL +
Sbjct: 623  EMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAK 682

Query: 897  FLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS------LKTDTGDT 950
              P L   + ++  ++  + +   +L++ IFIFS++GM LFG  F+      L   TG T
Sbjct: 683  SWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPT 742

Query: 951  VPDRKNF--DSLLWAIVTVFQILTQEDWNVVLYNGMA---STSSWAALYFVALMTFGNYV 1005
            V   +++       + + VF+IL  E W   ++  M    ++SS   + F+ +   G  V
Sbjct: 743  VSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLV 801

Query: 1006 LFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEED 1041
            + NL +A+L+  F  E      + +  KT V    D
Sbjct: 802  VLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALD 837



 Score =  119 bits (299), Expect = 3e-26
 Identities = 95/358 (26%), Positives = 161/358 (44%), Gaps = 50/358 (13%)

Query: 68  QRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVE 127
           +R  Y   A    F  G     RS  +R+  +  F    +  +++NCV +    P ++  
Sbjct: 97  KRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMAT-GPAKN-- 153

Query: 128 CGSERCNILEAFDAFIFAFFAVEMVIKMVALG-LFGQKCYLGDTWNRLDFFIVVAGMMEY 186
             S   +I E     I+ F   E +IK++A G +  +  +L D WN LD  ++   ++ Y
Sbjct: 154 SNSNNTDIAECVFTGIYIF---EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSY 210

Query: 187 SLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGI 246
            + G  + L  +RT RV R L+AI+ V  ++++V  LL ++  L NV++L FF   IF +
Sbjct: 211 -IPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFAL 269

Query: 247 VGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP 306
           VG QL+ G L  +C          N++    Y    E +EN                   
Sbjct: 270 VGQQLFMGSLNLKCISRDC----KNISNPEAYDHCFEKKEN------------------- 306

Query: 307 GRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGY 366
              E +M C             G+    +AC         C+    NP     NFDN G+
Sbjct: 307 -SPEFKM-C-------------GIWMGNSAC----SIQYECKHTKINPDYNYTNFDNFGW 347

Query: 367 AWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSE 424
           +++A+F+++T + W  +    +     Y+  +FI++I +GSF++INL L V+   + E
Sbjct: 348 SFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEE 405



 Score =  112 bits (281), Expect = 3e-24
 Identities = 81/347 (23%), Positives = 163/347 (46%), Gaps = 55/347 (15%)

Query: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332
            AL++F P N  R    +V  H +F   ++  + +NCV +A   P  +  S       ++ 
Sbjct: 108  ALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATG-PAKNSNSNNT---DIAE 163

Query: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392
             +FT I++ E ++K++A G +  E ++L+  WN LD +++ +++V  +  +      K+L
Sbjct: 164  CVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGIT----IKLL 219

Query: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452
              LR  R+ R L+ + V+SR   LK++V  L+ S++ + N++++      IF ++G QLF
Sbjct: 220  -PLRTFRVFRALKAISVVSR---LKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLF 275

Query: 1453 KGKF-YYCEGPDTRNIST-------------------------------KAQCRAAHYRW 1480
             G     C   D +NIS                                + +C+      
Sbjct: 276  MGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINP 335

Query: 1481 VRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLL 1540
                 NFDN G + +++F L ++D W  +           QQ ++    + + +FI  + 
Sbjct: 336  DYNYTNFDNFGWSFLAMFRLMTQDSWEKLY----------QQTLRTTGLYSVFFFIVVIF 385

Query: 1541 IVSFFVLNMFVGVVVENFHKCRQHQEAE-EARRREEKRLRRLERRRR 1586
            + SF+++N+ + VV   + +  ++  AE EA+ +  +  ++L +  +
Sbjct: 386  LGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEK 432



 Score =  110 bits (275), Expect = 2e-23
 Identities = 69/280 (24%), Positives = 138/280 (49%), Gaps = 27/280 (9%)

Query: 1607 RRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAAL 1666
            ++ + ++ T  + +L IT  I +N + ++MEH+    S ++ L   N VFT +F+ E  L
Sbjct: 567  KKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCL 626

Query: 1667 KLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVL 1726
            K++A     +F+  WN  D  + LLS   + +  +    + P        +R  R+ RV 
Sbjct: 627  KIIALDPYHYFRRGWNIFDSIVALLSFADV-MNCVLQKRSWP-------FLRSFRVLRVF 678

Query: 1727 KLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR--------LECSE 1778
            KL K    +  L+  +  ++  +G+L ++ +++ FI++ +G++LFGR          C+ 
Sbjct: 679  KLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNP 738

Query: 1779 DNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPV 1838
              P     RH    +F  +FL +FR+  G+ W   M + ++E +     C+        +
Sbjct: 739  TGPTVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSSLCV--------I 789

Query: 1839 YFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDA 1878
             F+   ++ + V++N+ +A+L+     SN+E   + E +A
Sbjct: 790  VFILITVIGKLVVLNLFIALLLNSF--SNEERNGNLEGEA 827



 Score =  102 bits (254), Expect = 4e-21
 Identities = 73/273 (26%), Positives = 132/273 (48%), Gaps = 28/273 (10%)

Query: 789  IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG 848
            IV S+ F   I+  I++N +SM  E + QP+ + + L+  N VF  +F LE L+K+ A  
Sbjct: 1362 IVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR 1421

Query: 849  PLGYIRNPYNIFDGIIVVISV----------WEIVGQADGGLSVLRTFRLLRVLKLVRFL 898
               Y  N +N+FD ++V++S+           E +        ++R  R+ R+L+LVR  
Sbjct: 1422 QY-YFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAA 1480

Query: 899  PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFD 958
              +R  L  L+ ++ ++     LL L +FI++ILGM+ F      K +    + D  NF 
Sbjct: 1481 RGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS-----KVNPESGIDDIFNFK 1535

Query: 959  SLLWAIVTVFQILTQEDWNVVLYNGMASTSSW------------AALYFVALMTFGNYVL 1006
            +   +++ +FQI T   W+ +L   + S  S             A  YFV+ +     ++
Sbjct: 1536 TFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATSYFVSYIIISFLIV 1595

Query: 1007 FNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039
             N+ +A+++E F    + +     ED   + +E
Sbjct: 1596 VNMYIAVILENFNTATEESEDPLGEDDFDIFYE 1628



 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 70/292 (23%), Positives = 136/292 (46%), Gaps = 31/292 (10%)

Query: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338
            P N+ +     ++T ++FD +++  I LN +++  E    +     +  L   N++F  I
Sbjct: 1351 PLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAE--SYNQPKAMKSILDHLNWVFVVI 1408

Query: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL--GVLR 1396
            F  E ++K+ AL        Y  + WNL D ++VL+S+V  +++             + R
Sbjct: 1409 FTLECLIKIFAL-----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFR 1463

Query: 1397 VLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKF 1456
            ++RL R  R LR++  A G++ ++  L+ SL  + NI L+      I+ ILG+  F    
Sbjct: 1464 IVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFS--- 1520

Query: 1457 YYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDA 1516
                             +      +   +NF     +++ LF +S+  GW +++   L +
Sbjct: 1521 -----------------KVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRS 1563

Query: 1517 VGVDQQPVQN-HNPWMLL-YFISFLLIVSFFVLNMFVGVVVENFHKCRQHQE 1566
                    +N H P +   YF+S+++I    V+NM++ V++ENF+   +  E
Sbjct: 1564 KESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESE 1615



 Score = 92.4 bits (228), Expect = 5e-18
 Identities = 71/286 (24%), Positives = 133/286 (46%), Gaps = 42/286 (14%)

Query: 771  EPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEIS 828
            +P W+  +W        +IV   +F   I+  IL+++ ++  E  + E   ++   L  +
Sbjct: 1036 KPPWV--IWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCT 1093

Query: 829  NIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRL 888
            +I+FT +F LEM+LK +A G   Y  + +   D IIV++SV  ++      L  L++FR 
Sbjct: 1094 DIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-----NLMELKSFRT 1148

Query: 889  LRVLKLVRFLPALRRQLVV---LVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKT 945
            LR L+ +R L       VV   L+  +  +     + ++F  +F ILG++ F  KF    
Sbjct: 1149 LRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCI 1208

Query: 946  DTGDTV--------------------PDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 985
            +  D+V                      + NFD++  A + + Q+ T + W  ++Y  + 
Sbjct: 1209 NGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVD 1268

Query: 986  ST----------SSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
            ST          +S   +YFV  + FG++   NL + ++++ F  +
Sbjct: 1269 STEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1314



 Score = 88.2 bits (217), Expect = 9e-17
 Identities = 76/335 (22%), Positives = 139/335 (41%), Gaps = 87/335 (25%)

Query: 1607 RRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAAL 1666
            R S+HSL       +FI   + +N + M+        S +  +  C  VFT +++FEA +
Sbjct: 124  RVSVHSL-----FSMFIIGTVIINCVFMATGPAKNSNSNNTDIAEC--VFTGIYIFEALI 176

Query: 1667 KLVAFGFR----RFFKDRWNQLDLAIVLLSLM----GITLEEIEMSAALPINPTIIRIMR 1718
            K++A GF      F +D WN LD  ++ ++++    GIT++       LP+        R
Sbjct: 177  KILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK------LLPL--------R 222

Query: 1719 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF------- 1771
              R+ R LK + + + ++ ++  +++++ ++ N+ +L      I+A +G +LF       
Sbjct: 223  TFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLK 282

Query: 1772 -----------------------------------GRLECSEDNPCEGLS-----RHATF 1791
                                               G   CS    C+         +  F
Sbjct: 283  CISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNF 342

Query: 1792 SNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVL 1851
             NFG +FL +FR+ T D+W  + + TLR                S  +F+  + +  F L
Sbjct: 343  DNFGWSFLAMFRLMTQDSWEKLYQQTLRTTG-----------LYSVFFFIVVIFLGSFYL 391

Query: 1852 VNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQ 1886
            +N+ +AV+    EE NK    + E   ++  E  Q
Sbjct: 392  INLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQ 426



 Score = 86.3 bits (212), Expect = 3e-16
 Identities = 68/298 (22%), Positives = 142/298 (47%), Gaps = 28/298 (9%)

Query: 1290 VITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVA 1349
            V+T    +  + + I +N V +A+E   ++  S E++ L++ N +FT+IF+AEM +K++A
Sbjct: 573  VMTDPFTELAITICIIINTVFLAMEHHKME-ASFEKM-LNIGNLVFTSIFIAEMCLKIIA 630

Query: 1350 LGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRV 1409
            L      + Y +  WN+ D ++ L+S  D++  +        L   RVLR+ +  +    
Sbjct: 631  L----DPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSW-- 684

Query: 1410 ISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIST 1469
                P L  +++ + +S+  +G++ ++      IF ++G+QLF   F   + P   N + 
Sbjct: 685  ----PTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTG 740

Query: 1470 KAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNP 1529
                   H+      ++F      L+   +L  +  W+  M++ +       Q     + 
Sbjct: 741  PTVSCLRHWHMGDFWHSF------LVVFRILCGE--WIENMWECM-------QEANASSS 785

Query: 1530 WMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRS 1587
              ++ FI   +I    VLN+F+ +++ +F    ++   E   R+ + +L  L+R RR+
Sbjct: 786  LCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQL-ALDRFRRA 842



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 56/167 (33%), Positives = 89/167 (53%), Gaps = 12/167 (7%)

Query: 90   RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFF 147
            R  C ++V + WFE   + VI+L+   L      EDV   ++     +L   D      F
Sbjct: 1046 RKTCYQIVKHSWFESFIIFVILLSSGALIF----EDVHLENQPKIQELLNCTDIIFTHIF 1101

Query: 148  AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPL 207
             +EMV+K VA G FG+  Y    W  LDF IV+  +       + + L + RT+R LRPL
Sbjct: 1102 ILEMVLKWVAFG-FGK--YFTSAWCCLDFIIVIVSVTTLI---NLMELKSFRTLRALRPL 1155

Query: 208  RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254
            RA+++   M+++V  L+  +P + NVLL+C   + +F I+GV  ++G
Sbjct: 1156 RALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSG 1202



 Score = 85.5 bits (210), Expect = 6e-16
 Identities = 68/311 (21%), Positives = 137/311 (44%), Gaps = 55/311 (17%)

Query: 788  RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847
            R+     FS  I+  +++N + M     +     +N  +I+  VFT ++  E L+K+LA 
Sbjct: 124  RVSVHSLFSMFIIGTVIINCVFMATGPAKNSN--SNNTDIAECVFTGIYIFEALIKILAR 181

Query: 848  G----PLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRR 903
            G       ++R+P+N  D I++ I++   +      L  LRTFR+ R LK +  +  L+ 
Sbjct: 182  GFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKV 241

Query: 904  QLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGD-------------- 949
             +  L++++  +     L    + IF+++G  LF    +LK  + D              
Sbjct: 242  IVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCF 301

Query: 950  ----TVPDRK-----------------------------NFDSLLWAIVTVFQILTQEDW 976
                  P+ K                             NFD+  W+ + +F+++TQ+ W
Sbjct: 302  EKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSW 361

Query: 977  NVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSV 1036
              +    + +T  ++  +F+ ++  G++ L NL +A++   ++ E + N +   E K  +
Sbjct: 362  EKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYE-EQNKNVAAEIEAKEKM 420

Query: 1037 HFEEDFHKLRE 1047
             F+E    L+E
Sbjct: 421  -FQEAQQLLKE 430



 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 42/135 (31%), Positives = 72/135 (53%), Gaps = 13/135 (9%)

Query: 347  CRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA----------HSFYNF 396
            C SG+ +  N  +NFDN+G A++A+ QV T +GW+DI+Y  +D+           +   +
Sbjct: 1226 CESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGY 1285

Query: 397  IYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDSTLASFSEP 453
            IYF++ II GSFF +NL + VI   F++ +++   +   M E++ ++ +    L S    
Sbjct: 1286 IYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQ 1345

Query: 454  GSCYEELLKYVGHIF 468
                  L K  G +F
Sbjct: 1346 KPIPRPLNKCQGLVF 1360



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 23/226 (10%)

Query: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
            +V +  F+ + + +I+LN +++      E         +IL+  +      F +E +IK+
Sbjct: 1362 IVTSQIFDIIIISLIILNMISM----MAESYNQPKAMKSILDHLNWVFVVIFTLECLIKI 1417

Query: 156  VALGLFGQKCYLGDTWNRLDFFIV---VAGMMEYSLDGHN------VSLSAIRTVRVLRP 206
             AL    ++ Y  + WN  D  +V   +   M  +L+              +R  R+ R 
Sbjct: 1418 FAL----RQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRI 1473

Query: 207  LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAF 266
            LR +     +R L+  L+ +LP L N+ LL F + FI+ I+G+  W   +     +D  F
Sbjct: 1474 LRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMN-WFSKVNPESGIDDIF 1532

Query: 267  VRNNNLTFLRPYYQ--TEEGEE---NPFICSSRRDNGMQKCSHIPG 307
                  + +   +Q  T  G +   +P + S    N   +  H+PG
Sbjct: 1533 NFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPG 1578



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 41/160 (25%), Positives = 78/160 (48%), Gaps = 12/160 (7%)

Query: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
           ++ +P+ E    + I++N V L M      +E   E+  +L   +    + F  EM +K+
Sbjct: 573 VMTDPFTELAITICIIINTVFLAMEH--HKMEASFEK--MLNIGNLVFTSIFIAEMCLKI 628

Query: 156 VALGLFGQKCYLGDTWNRLDFFIVV---AGMMEYSLDGHNVSLSAIRTVRVLRPLRAINR 212
           +AL  +    Y    WN  D  + +   A +M   L     S   +R+ RVLR  +    
Sbjct: 629 IALDPYH---YFRRGWNIFDSIVALLSFADVMNCVLQKR--SWPFLRSFRVLRVFKLAKS 683

Query: 213 VPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
            P++  L+ ++ +++  LG++ ++   V FIF +VG+QL+
Sbjct: 684 WPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723



 Score = 34.3 bits (77), Expect = 1.5
 Identities = 20/75 (26%), Positives = 42/75 (56%), Gaps = 5/75 (6%)

Query: 366 YAWIAIFQVITLEGWVDIMYYVM---DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 422
           ++++ +F+++  E W++ M+  M   +A S    I FIL+ ++G   ++NL + ++   F
Sbjct: 756 HSFLVVFRILCGE-WIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSF 814

Query: 423 SETKQRESQLMREQR 437
           S  ++R   L  E R
Sbjct: 815 S-NEERNGNLEGEAR 828



 Score = 31.6 bits (70), Expect = 9.6
 Identities = 22/94 (23%), Positives = 40/94 (42%), Gaps = 16/94 (17%)

Query: 353  NPHNGA---INFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFI------------ 397
            NP +G     NF     + + +FQ+ T  GW  ++  ++ +    N              
Sbjct: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582

Query: 398  YFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 431
            YF+  II+    ++N+ + VI   F+ T   ES+
Sbjct: 1583 YFVSYIIISFLIVVNMYIAVILENFN-TATEESE 1615


>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
            sapiens]
          Length = 1977

 Score =  337 bits (865), Expect = 6e-92
 Identities = 207/659 (31%), Positives = 368/659 (55%), Gaps = 48/659 (7%)

Query: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343
            R +C K++ H  F+  +++ I L+   +A E   I+   T ++ L  ++ IFT IF+ EM
Sbjct: 1171 RKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEM 1230

Query: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403
            ++K +A G  +    Y  ++W  LD L+V VSLV +V   A+  G   LG ++ LR LR 
Sbjct: 1231 LLKWIAYGYKT----YFTNAWCWLDFLIVDVSLVTLV---ANTLGYSDLGPIKSLRTLRA 1283

Query: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1463
            LRPLR +SR  G+++VV  LI ++  I N++L+C  F++IF I+GV LF GKFY C    
Sbjct: 1284 LRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTT 1343

Query: 1464 ------TRNISTKAQCRAA-----HYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYD 1512
                     +  +++C A      + RW   K NFDN+G   +SL  +++  GW  IMY 
Sbjct: 1344 DGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYA 1403

Query: 1513 GLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEA-R 1571
             +D+V VD+QP   ++ +M +YF+ F++  SFF LN+F+GV+++NF++ ++    ++   
Sbjct: 1404 AVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFM 1463

Query: 1572 RREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNV 1631
              E+K+     ++  S  P     ++P     +  +  I  L T+   D+ I  +IC+N+
Sbjct: 1464 TEEQKKYYNAMKKLGSKKP-----QKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNM 1518

Query: 1632 ITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLL 1691
            +TM +E   Q + + E L + N VF I+F  E  LKL++     +F   WN  D  +V++
Sbjct: 1519 VTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR-HYYFTVGWNIFDFVVVII 1577

Query: 1692 SLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGN 1751
            S++G+ L   ++     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N
Sbjct: 1578 SIVGMFL--ADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFN 1635

Query: 1752 LGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWN 1811
            +GLL  L+ FIYA  G+  F  ++  ED    G++    F  FG + + LF+++T   W+
Sbjct: 1636 IGLLLFLVMFIYAIFGMSNFAYVK-KED----GINDMFNFETFGNSMICLFQITTSAGWD 1690

Query: 1812 GIMKDTLR----ECSREDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMK 1861
            G++   L     +C  +  H  S +      P++   YFV++++++  V+VN+ +AV+++
Sbjct: 1691 GLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILE 1750

Query: 1862 HLEESNKEARED-AELDAEIELEMAQ--GPGSARRVDADRPPLPQESPGARDAPNLVAR 1917
            +   + +E+ E  +E D E+  E+ +   P + + ++  +     +   A D P L+A+
Sbjct: 1751 NFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSK---LSDFAAALDPPLLIAK 1806



 Score =  158 bits (399), Expect = 7e-38
 Identities = 198/895 (22%), Positives = 373/895 (41%), Gaps = 179/895 (20%)

Query: 788  RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLA- 846
            +I+    FS  IM  IL N + M +     P + T  +E +   FT ++  E L+K+LA 
Sbjct: 121  KILVHSLFSMLIMCTILTNCIFMTMN---NPPDWTKNVEYT---FTGIYTFESLVKILAR 174

Query: 847  ---CGPLGYIRNPYNIFDGIIVVIS-VWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902
                G   ++R+P+N  D +++V + + E V    G +S LRTFR+LR LK +  +P L+
Sbjct: 175  GFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNL--GNVSALRTFRVLRALKTISVIPGLK 232

Query: 903  RQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF------------------------- 937
              +  L++++  ++    L +  + +F+++G+ LF                         
Sbjct: 233  TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNT 292

Query: 938  ---------------GCKFSL----KTDTGDTV-----------PDR--KNFDSLLWAIV 965
                           G K +L     TD+G              PD    +FD+  WA +
Sbjct: 293  LESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFL 352

Query: 966  TVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDAN 1025
             +F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++   ++ +  AN
Sbjct: 353  ALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQAN 412

Query: 1026 RSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPM 1085
              +  + +  + F++   +L++ Q     + + A     +   R S    L   ++ T  
Sbjct: 413  IEEAKQKE--LEFQQMLDRLKKEQEEAEAIAAAAAE---YTSIRRSRIMGLSESSSETSK 467

Query: 1086 PTPKSSPF------------LDAAPSLPDSRRGSSSSGDPPL----------GDQKPPAS 1123
             + KS+              L +     D+ + S S  +  +          G ++    
Sbjct: 468  LSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEK 527

Query: 1124 LRSSPC-APWGPSGA-WSSRRSSWSSLGRAPSLKRRGQ-CGERESLLSGEGKGSTDDEAE 1180
              S+P  +P    G+ +S+RRSS +SL    S K RG+  G        E     D+E+ 
Sbjct: 528  RLSTPNQSPLSIRGSLFSARRSSRTSLF---SFKGRGRDIGSETEFADDEHSIFGDNESR 584

Query: 1181 DGRAAPGPRATPLRRAESLDPRPLRPAALPPT----KCRDRDGQV--------VALPSDF 1228
             G     P     RR+ ++      P  LP         D +G V        + LP+  
Sbjct: 585  RGSLFV-PHRPQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQ 643

Query: 1229 FL------------RIDSHREDAAELDDDSEDSCCLRLHKVL-----------EPYKPQW 1265
             L            R  S+      L+D +     +    +L           +   P W
Sbjct: 644  LLPEGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWW 703

Query: 1266 CRSREAWALYLFSPQ-NRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTE 1324
             R    + ++  SP   +F+     ++     D  + + I LN + +A+E     P + E
Sbjct: 704  YRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEH---HPMTEE 760

Query: 1325 -RVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAM 1383
             +  L++ N +FT IF AEM++K++A+      + Y Q  WN+ D L+V +SLV++ +A 
Sbjct: 761  FKNVLAIGNLVFTGIFAAEMVLKLIAMD----PYEYFQVGWNIFDSLIVTLSLVELFLAD 816

Query: 1384 ASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFII 1443
                       L VLR  R LR  ++    P L ++++ + +S+  +GN+ L+      I
Sbjct: 817  VEG--------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFI 868

Query: 1444 FGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSK 1503
            F ++G+QLF GK Y            +  C+      + R +  D     L+   VL  +
Sbjct: 869  FAVVGMQLF-GKSY-----------KECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE 916

Query: 1504 DGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558
              W+  M+D ++  G             L+ ++  ++I +  VLN+F+ +++ +F
Sbjct: 917  --WIETMWDCMEVAG---------QAMCLIVYMMVMVIGNLVVLNLFLALLLSSF 960



 Score =  143 bits (361), Expect = 2e-33
 Identities = 86/258 (33%), Positives = 144/258 (55%), Gaps = 9/258 (3%)

Query: 779  WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838
            W+ F   +  IV   +    I + I++NTL M +E+H   EE  N L I N+VFT +FA 
Sbjct: 719  WIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAA 778

Query: 839  EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898
            EM+LKL+A  P  Y +  +NIFD +IV +S+ E+      GLSVLR+FRLLRV KL +  
Sbjct: 779  EMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSW 838

Query: 899  PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS---LKTDTGDTVPDRK 955
            P L   + ++  ++  +     +L + +FIF+++GM LFG  +     K +   T+P R 
Sbjct: 839  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 897

Query: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAIL 1014
            + +    + + VF++L  E W   +++ M  +  +   + ++ +M  GN V+ NL +A+L
Sbjct: 898  HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALL 956

Query: 1015 VEGFQAEGDANRSDTDED 1032
            +  F ++   N +  +ED
Sbjct: 957  LSSFSSD---NLTAIEED 971



 Score =  137 bits (344), Expect = 2e-31
 Identities = 107/382 (28%), Positives = 170/382 (44%), Gaps = 95/382 (24%)

Query: 90   RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCN--ILEAFDAFIFAFF 147
            R  C ++V + WFE   +L+I+L+   L      ED+    ++    ILE  D      F
Sbjct: 1171 RKTCYKIVEHSWFESFIVLMILLSSGALAF----EDIYIERKKTIKIILEYADKIFTYIF 1226

Query: 148  AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAIRT 200
             +EM++K +A   +G K Y  + W  LDF IV       VA  + YS  G    + ++RT
Sbjct: 1227 ILEMLLKWIA---YGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLG---PIKSLRT 1280

Query: 201  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 260
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG      
Sbjct: 1281 LRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG------ 1334

Query: 261  FLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWE 320
                             +Y+          C +  D      S +P R E      +   
Sbjct: 1335 ----------------KFYE----------CINTTDGSRFPASQVPNRSECFALMNVSQN 1368

Query: 321  AYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGW 380
                             + W               N  +NFDN+G  ++++ QV T +GW
Sbjct: 1369 -----------------VRWK--------------NLKVNFDNVGLGYLSLLQVATFKGW 1397

Query: 381  VDIMYYVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-- 428
              IMY  +D+          +S Y +IYF++ II GSFF +NL + VI   F++ K++  
Sbjct: 1398 TIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLG 1457

Query: 429  -ESQLMREQRARHLSNDSTLAS 449
             +   M E++ ++ +    L S
Sbjct: 1458 GQDIFMTEEQKKYYNAMKKLGS 1479



 Score =  127 bits (318), Expect = 2e-28
 Identities = 93/365 (25%), Positives = 168/365 (46%), Gaps = 69/365 (18%)

Query: 76  AATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNI 135
           A    + L   +  R   ++++ +  F  + M  I+ NC+ + M  P +  +      N+
Sbjct: 102 ATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTK------NV 155

Query: 136 LEAFDAFIFAFFAVEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVS 194
              F       +  E ++K++A G   G+  +L D WN LDF ++V   +   ++  NVS
Sbjct: 156 EYTFTGI----YTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVS 211

Query: 195 LSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254
             A+RT RVLR L+ I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G
Sbjct: 212 --ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 269

Query: 255 LLRNRCFLDSAFVRNNNLTF------------LRPYYQTEEGEENPFICSSRRDNGMQKC 302
            L+++CF +S     NN T              R Y+   EG ++  +C    D+G  +C
Sbjct: 270 NLKHKCFRNSL---ENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSG--QC 324

Query: 303 SHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFD 362
                            E YT                       C     NP  G  +FD
Sbjct: 325 P----------------EGYT-----------------------CVKIGRNPDYGYTSFD 345

Query: 363 NIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 422
              +A++A+F+++T + W ++    + A      I+F+++I +GSF++INL L V+A  +
Sbjct: 346 TFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAY 405

Query: 423 SETKQ 427
            E  Q
Sbjct: 406 EEQNQ 410



 Score =  122 bits (305), Expect = 5e-27
 Identities = 99/380 (26%), Positives = 169/380 (44%), Gaps = 74/380 (19%)

Query: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332
            ALY+ SP +  R    K++ H +F  +++  I  NC+ + +  P   P  T+ V      
Sbjct: 105  ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP---PDWTKNV-----E 156

Query: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392
            Y FT I+  E +VK++A G   GE  +L+  WN LD ++++ + +   V          L
Sbjct: 157  YTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN---------L 207

Query: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452
            G +  LR  R LR L+ IS  PGLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 208  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 267

Query: 1453 KGK--------------------------------FYYCEGPDTR---NISTKAQCRAAH 1477
             G                                 FYY EG         ST +      
Sbjct: 268  MGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEG 327

Query: 1478 YRWVRRKYN-------FDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPW 1530
            Y  V+   N       FD    A ++LF L ++D W N+    L A G            
Sbjct: 328  YTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAG----------KT 377

Query: 1531 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRSTFP 1590
             +++F+  + + SF+++N+ + VV   + +  Q    EEA+++E +  + L+R ++    
Sbjct: 378  YMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQ-ANIEEAKQKELEFQQMLDRLKKE--- 433

Query: 1591 SPEAQR-RPYYADYSPTRRS 1609
              EA+      A+Y+  RRS
Sbjct: 434  QEEAEAIAAAAAEYTSIRRS 453



 Score =  108 bits (270), Expect = 6e-23
 Identities = 75/280 (26%), Positives = 137/280 (48%), Gaps = 30/280 (10%)

Query: 1598 PYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFT 1657
            PY+  +   ++ I+ +    ++DL IT  I +N + M+MEH+   +     L   N VFT
Sbjct: 717  PYWIKF---KKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFT 773

Query: 1658 IVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIM 1717
             +F  E  LKL+A     +F+  WN  D  IV LSL+ + L ++E           + ++
Sbjct: 774  GIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG----------LSVL 823

Query: 1718 RVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR---- 1773
            R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FI+A +G++LFG+    
Sbjct: 824  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKE 883

Query: 1774 LECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLP 1833
              C  ++ C     H   ++F  +FL +FRV  G+ W   M D +    +          
Sbjct: 884  CVCKINDDCTLPRWH--MNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ---------- 930

Query: 1834 ALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEARED 1873
            A+  + ++  +++   V++N+ +A+L+      N  A E+
Sbjct: 931  AMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEE 970



 Score =  106 bits (264), Expect = 3e-22
 Identities = 75/291 (25%), Positives = 142/291 (48%), Gaps = 38/291 (13%)

Query: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338
            P N+ +     ++T++ FD  ++V I LN VT+ +E+       TE ++    N +F  +
Sbjct: 1489 PGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYW--INVVFIIL 1546

Query: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398
            F  E ++K+++L      H Y    WN+ D ++V++S+V + +A           + RV+
Sbjct: 1547 FTGECVLKLISL-----RHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVI 1601

Query: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458
            RL R  R LR++  A G++ ++  L+ SL  + NI L+      I+ I G+      F Y
Sbjct: 1602 RLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAY 1657

Query: 1459 CEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518
             +  D                 +   +NF+  G +++ LF +++  GW  ++   L++  
Sbjct: 1658 VKKED----------------GINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKP 1701

Query: 1519 VDQQPVQNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1558
             D  P + H          NP + + YF+S+++I    V+NM++ V++ENF
Sbjct: 1702 PDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENF 1752



 Score =  103 bits (256), Expect = 3e-21
 Identities = 75/289 (25%), Positives = 140/289 (48%), Gaps = 43/289 (14%)

Query: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833
            G++W        +IV+  +F   I++ IL+++ ++  E  Y E+ + +   LE ++ +FT
Sbjct: 1164 GKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFT 1223

Query: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIV----GQAD-GGLSVLRTFRL 888
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V    G +D G +  LRT R 
Sbjct: 1224 YIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRA 1283

Query: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTG 948
            LR L+ +     +R  +  L+  + ++     + ++F  IFSI+G++LF  KF    +T 
Sbjct: 1284 LRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTT 1343

Query: 949  D-------TVPDRK-------------------NFDSLLWAIVTVFQILTQEDWNVVLYN 982
            D        VP+R                    NFD++    +++ Q+ T + W +++Y 
Sbjct: 1344 DGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYA 1403

Query: 983  GMAST----------SSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
             + S           S +  +YFV  + FG++   NL + ++++ F  +
Sbjct: 1404 AVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1452



 Score = 92.8 bits (229), Expect = 4e-18
 Identities = 80/345 (23%), Positives = 144/345 (41%), Gaps = 92/345 (26%)

Query: 1603 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1662
            +SP RR    +       + I   I  N I M+M   N P    +  K   Y FT ++ F
Sbjct: 112  FSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMN--NPP----DWTKNVEYTFTGIYTF 165

Query: 1663 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1718
            E+ +K++A GF      F +D WN LD  +++ +     L E        +N   +  +R
Sbjct: 166  ESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAY----LTEF-------VNLGNVSALR 214

Query: 1719 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GRL--- 1774
              R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF G L   
Sbjct: 215  TFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHK 274

Query: 1775 ------------------------------------------------ECSEDNPCEGLS 1786
                                                            +C E   C  + 
Sbjct: 275  CFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIG 334

Query: 1787 R-----HATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFV 1841
            R     + +F  F  AFL LFR+ T D W  + + TLR   +      +Y+     ++FV
Sbjct: 335  RNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGK------TYM-----IFFV 383

Query: 1842 TFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQ 1886
              + +  F L+N+++AV+    EE N+   E+A+   + ELE  Q
Sbjct: 384  VVIFLGSFYLINLILAVVAMAYEEQNQANIEEAK---QKELEFQQ 425



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 75/283 (26%), Positives = 129/283 (45%), Gaps = 41/283 (14%)

Query: 789  IVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG 848
            +V ++ F   IM+ I +N ++M VE   Q + +T  L   N+VF  +F  E +LKL++  
Sbjct: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLR 1559

Query: 849  PLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLRVLKLVRF 897
               Y    +NIFD ++V+IS   IVG     L            V+R  R+ R+L+LV+ 
Sbjct: 1560 HY-YFTVGWNIFDFVVVIIS---IVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKG 1615

Query: 898  LPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNF 957
               +R  L  L+ ++  +     LL L +FI++I GM  F     +K + G  + D  NF
Sbjct: 1616 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEDG--INDMFNF 1670

Query: 958  DSLLWAIVTVFQILTQEDWNVVL---------------------YNGMASTSSWAALYFV 996
            ++   +++ +FQI T   W+ +L                       G     S    YFV
Sbjct: 1671 ETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFV 1730

Query: 997  ALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039
            + +     V+ N+ +A+++E F    + +     ED   + +E
Sbjct: 1731 SYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYE 1773



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 44/157 (28%), Positives = 80/157 (50%), Gaps = 8/157 (5%)

Query: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
           +V +P+ +    + I+LN + + M    E      E  N+L   +      FA EMV+K+
Sbjct: 729 IVMDPFVDLAITICIVLNTLFMAM----EHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKL 784

Query: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215
           +A+  +    Y    WN  D  IV   ++E  L      LS +R+ R+LR  +     P+
Sbjct: 785 IAMDPYE---YFQVGWNIFDSLIVTLSLVELFLADVE-GLSVLRSFRLLRVFKLAKSWPT 840

Query: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 841 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 877



 Score = 55.8 bits (133), Expect = 5e-07
 Identities = 47/165 (28%), Positives = 77/165 (46%), Gaps = 15/165 (9%)

Query: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
            LV N  F+   M++I LN VT+ + +  +          +L   +      F  E V+K+
Sbjct: 1500 LVTNQAFDISIMVLICLNMVTMMVEKEGQS----QHMTEVLYWINVVFIILFTGECVLKL 1555

Query: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVS---LSAIRTVRVLRPLR 208
            ++L  +    Y    WN  DF +V+  ++   L    + + VS      IR  R+ R LR
Sbjct: 1556 ISLRHY----YFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILR 1611

Query: 209  AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253
             +     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1612 LVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1656



 Score = 35.8 bits (81), Expect = 0.51
 Identities = 20/101 (19%), Positives = 41/101 (40%), Gaps = 21/101 (20%)

Query: 356  NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA---------------------HSFY 394
            N   NF+  G + I +FQ+ T  GW  ++  ++++                     +   
Sbjct: 1665 NDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSV 1724

Query: 395  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 435
               YF+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 1725 GIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSE 1765


>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
            [Homo sapiens]
          Length = 1951

 Score =  333 bits (855), Expect = 9e-91
 Identities = 206/656 (31%), Positives = 360/656 (54%), Gaps = 45/656 (6%)

Query: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343
            R +C  ++ H  F+  ++  I L+   +A E   I+   T +  L  ++ +FT IF+ EM
Sbjct: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1206

Query: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403
            ++K VA G       Y  ++W  LD L+V VSLV +V   A+A G   LG ++ LR LR 
Sbjct: 1207 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1259

Query: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1463
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFY+C    
Sbjct: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319

Query: 1464 TRN------ISTKAQCRA--AHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLD 1515
            T N      ++  + C+A     RW   K NFDN+G   ++L  +++  GW++IMY  +D
Sbjct: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379

Query: 1516 AVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEA-RRRE 1574
            +  V  QPV   N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++     E
Sbjct: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1439

Query: 1575 EKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITM 1634
            +K+     ++  S  P     ++P     +  +  +    T    D+ I  +IC+N++TM
Sbjct: 1440 QKKYYNAMKKLGSKKP-----QKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTM 1494

Query: 1635 SMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLM 1694
             +E  +Q K +   L   N VF ++F  E  LKLV+     +F   WN  D  +V+LS++
Sbjct: 1495 MVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSIV 1553

Query: 1695 GITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGL 1754
            G+ L   EM     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GL
Sbjct: 1554 GMFL--AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL 1611

Query: 1755 LFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIM 1814
            L  L+ FIYA  G+  F  ++        G+     F  FG + + LF+++T   W+G++
Sbjct: 1612 LLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGLL 1666

Query: 1815 KDTLR----ECSREDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLE 1864
               L     +C  +  H  S +      P++   +FV++++++  V+VN+ +AV++++  
Sbjct: 1667 APILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFS 1726

Query: 1865 ESNKEARED-AELDAEIELEMAQ--GPGSARRVDADRPPLPQESPGARDAPNLVAR 1917
             + +E+ E  +E D E+  E+ +   P + + ++  +     +   A D P L+A+
Sbjct: 1727 VATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSK---LSDFAAALDPPLLIAK 1779



 Score =  141 bits (355), Expect = 9e-33
 Identities = 82/257 (31%), Positives = 143/257 (55%), Gaps = 6/257 (2%)

Query: 779  WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838
            W+     +  IV   +    I + I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 697  WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 756

Query: 839  EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898
            EM+LK++A  P  Y +  +NIFDGIIV +S+ E+      GLSVLR+FRLLRV KL +  
Sbjct: 757  EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 816

Query: 899  PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS---LKTDTGDTVPDRK 955
            P L   + ++  ++  +     +L + +FIF+++GM LFG  +     K +   T+P R 
Sbjct: 817  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 875

Query: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAIL 1014
            + +    + + VF++L  E W   +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 876  HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 934

Query: 1015 VEGFQAEGDANRSDTDE 1031
            +  F ++  A   D +E
Sbjct: 935  LSSFSSDNLAATDDDNE 951



 Score =  130 bits (326), Expect = 2e-29
 Identities = 108/470 (22%), Positives = 203/470 (43%), Gaps = 95/470 (20%)

Query: 76  AATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNI 135
           A +  + L      R   ++++ +  F  + M  I+ NCV + +  P +  +      N+
Sbjct: 104 ATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTK------NV 157

Query: 136 LEAFDAFIFAFFAVEMVIKMVALGLFGQK-CYLGDTWNRLDFFIVVAGMMEYSLDGHNVS 194
              F       +  E +IK++A G   +   +L D WN LDF ++V   +   +   NVS
Sbjct: 158 EYTFTGI----YTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVS 213

Query: 195 LSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254
             A+RT RVLR L+ I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G
Sbjct: 214 --ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271

Query: 255 LLRNRCF----LDSAFVRN----------NNLTFLR---------------PYYQTEEGE 285
            LRN+C      DSAF  N          +N TF+                 ++   +G+
Sbjct: 272 NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331

Query: 286 ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYN 345
           ++P +C +  D G                C  G+                          
Sbjct: 332 KDPLLCGNGSDAGQ---------------CPEGY-------------------------- 350

Query: 346 VCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIV 405
           +C     NP+ G  +FD   +A++++F+++T + W ++    + A      I+F+L+I +
Sbjct: 351 ICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFL 410

Query: 406 GSFFMINLCLVVIATQF----------SETKQRESQLMREQRARHLSNDSTLASFSEPGS 455
           GSF+++NL L V+A  +          +E K+ E Q M EQ  +       +A+ S    
Sbjct: 411 GSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASR 470

Query: 456 CYEEL--LKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHR 503
            +  +  L  +     +  + S +    W++R +K+     ++G   G R
Sbjct: 471 DFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGER 520



 Score =  115 bits (287), Expect = 7e-25
 Identities = 131/634 (20%), Positives = 260/634 (41%), Gaps = 91/634 (14%)

Query: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015
            +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424

Query: 1016 EGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPP 1075
              ++ +  A   + ++ +    F++   +L++ Q  E +  + A   +    G G L   
Sbjct: 425  MAYEEQNQATLEEAEQKEAE--FQQMLEQLKK-QQEEAQAVAAASAASRDFSGIGGLGEL 481

Query: 1076 LIMCTAATPMPTPK--------------------------SSPFLDAAPSLPDSRRGSSS 1109
            L   + A+ + +                            S P  ++  S+  S    S 
Sbjct: 482  LESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSM 541

Query: 1110 SGDPPLGDQK---PPASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESL 1166
             G+    D+K   P  SL S   + + P    +S+ S +S  GRA  +       + E  
Sbjct: 542  DGNRLTSDKKFCSPHQSLLSIRGSLFSPRR--NSKTSIFSFRGRAKDVGSENDFADDEHS 599

Query: 1167 LSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPS 1226
               + +   D      R      +        +  R L    +      D  G+  A+  
Sbjct: 600  TFEDSESRRDSLFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVS- 658

Query: 1227 DFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALY-LFSPQNRFRV 1285
                 I S   +  E  ++S   C            P W R    + ++       + + 
Sbjct: 659  -----IASILTNTMEELEESRQKC-----------PPCWYRFANVFLIWDCCDAWLKVKH 702

Query: 1286 SCQKVITHKMFDHVVLVFIFLNCVTIALER-PDIDPGSTERVFLSVSNYIFTAIFVAEMM 1344
                ++     D  + + I LN + +A+E  P  +  S+    L+V N +FT IF AEM+
Sbjct: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMV 759

Query: 1345 VKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTL 1404
            +K++A+      + Y Q  WN+ DG++V +SL+++        G   +  L VLR  R L
Sbjct: 760  LKIIAMD----PYYYFQEGWNIFDGIIVSLSLMEL--------GLSNVEGLSVLRSFRLL 807

Query: 1405 RPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDT 1464
            R  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF GK Y       
Sbjct: 808  RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY------- 859

Query: 1465 RNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPV 1524
                 +  C+      + R +  D     L+   VL  +  W+  M+D ++  G      
Sbjct: 860  ----KECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE--WIETMWDCMEVAG------ 907

Query: 1525 QNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558
                   L+ F+  ++I +  VLN+F+ +++ +F
Sbjct: 908  ---QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938



 Score =  109 bits (272), Expect = 4e-23
 Identities = 75/260 (28%), Positives = 128/260 (49%), Gaps = 27/260 (10%)

Query: 1618 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1677
            ++DL IT  I +N + M+MEHY   +     L   N VFT +F  E  LK++A     +F
Sbjct: 712  FVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYF 771

Query: 1678 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1737
            ++ WN  D  IV LSLM + L  +E           + ++R  R+ RV KL K    +  
Sbjct: 772  QEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKLAKSWPTLNM 821

Query: 1738 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR----LECSEDNPCEGLSRHATFSN 1793
            L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      C  ++ C     H   ++
Sbjct: 822  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWH--MND 879

Query: 1794 FGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1853
            F  +FL +FRV  G+ W   M D +    +    CL        + F+  +++   V++N
Sbjct: 880  FFHSFLIVFRVLCGE-WIETMWDCMEVAGQ--TMCL--------IVFMLVMVIGNLVVLN 928

Query: 1854 VVVAVLMKHLEESNKEARED 1873
            + +A+L+      N  A +D
Sbjct: 929  LFLALLLSSFSSDNLAATDD 948



 Score =  106 bits (265), Expect = 2e-22
 Identities = 76/291 (26%), Positives = 138/291 (47%), Gaps = 38/291 (13%)

Query: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338
            P N+F+      +T ++FD  +++ I LN VT+ +E    D G    + LS  N +F  +
Sbjct: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1519

Query: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398
            F  E ++K+V+L      H Y    WN+ D ++V++S+V + +A           + RV+
Sbjct: 1520 FTGEFVLKLVSL-----RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1574

Query: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1575 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1628

Query: 1459 CEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518
                                  +   +NF+  G +++ LF +++  GW  ++   L++  
Sbjct: 1629 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1674

Query: 1519 VDQQPVQNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1558
             D  P   H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1675 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1725



 Score =  100 bits (250), Expect = 1e-20
 Identities = 79/280 (28%), Positives = 129/280 (46%), Gaps = 28/280 (10%)

Query: 1186 PGPRATPLRRAESL---DPRPLRPAALPPTKCRDRDGQVVALP-SDF-------FLRIDS 1234
            PGP +  L   ESL   + R     A  P K +D D +    P SD        F+  D 
Sbjct: 9    PGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDI 68

Query: 1235 HREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHK 1294
              E  +E  +D +     +   ++        R     ALY+ +P N  R    K++ H 
Sbjct: 69   PPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHS 128

Query: 1295 MFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLS 1354
            +F  +++  I  NCV + L  P   P  T+ V      Y FT I+  E ++K++A G   
Sbjct: 129  LFSMLIMCTILTNCVFMTLSNP---PDWTKNV-----EYTFTGIYTFESLIKILARGFCL 180

Query: 1355 GEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAP 1414
             +  +L+  WN LD  +++++ V   V+         LG +  LR  R LR L+ IS  P
Sbjct: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVS---------LGNVSALRTFRVLRALKTISVIP 231

Query: 1415 GLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKG 1454
            GLK +V  LI S++ + +++++      +F ++G+QLF G
Sbjct: 232  GLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 74/286 (25%), Positives = 133/286 (46%), Gaps = 40/286 (13%)

Query: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833
            G++W         IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT
Sbjct: 1140 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1199

Query: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA-----DGGLSVLRTFRL 888
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V  A      G +  LRT R 
Sbjct: 1200 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1259

Query: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKF----SLK 944
            LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  KF    ++ 
Sbjct: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319

Query: 945  TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 985
            T     + D                   + NFD++    + + Q+ T + W  ++Y  + 
Sbjct: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379

Query: 986  S----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
            S           + +  LYFV  + FG++   NL + ++++ F  +
Sbjct: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1425



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 61/174 (35%), Positives = 93/174 (53%), Gaps = 19/174 (10%)

Query: 90   RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFF 147
            R  C  +V + WFE   + +I+L+   L      ED+     +    +LE  D      F
Sbjct: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1202

Query: 148  AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAIRT 200
             +EM++K VA   +G + Y  + W  LDF IV       VA  + YS  G   ++ ++RT
Sbjct: 1203 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELG---AIKSLRT 1256

Query: 201  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 1257 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 73/290 (25%), Positives = 131/290 (45%), Gaps = 41/290 (14%)

Query: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841
            F G +   V  + F   IM+ I +N ++M VE  +Q + +T  L   N+VF  +F  E +
Sbjct: 1466 FQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFV 1525

Query: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQ-----------ADGGLSVLRTFRLLR 890
            LKL++     Y    +NIFD ++V++S   IVG            +     V+R  R+ R
Sbjct: 1526 LKLVSLRHY-YFTIGWNIFDFVVVILS---IVGMFLAEMIEKYFVSPTLFRVIRLARIGR 1581

Query: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950
            +L+L++    +R  L  L+ ++  +     LL L +FI++I GM  F     +K + G  
Sbjct: 1582 ILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG-- 1636

Query: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL---------------------YNGMASTSS 989
            + D  NF++   +++ +FQI T   W+ +L                       G     S
Sbjct: 1637 IDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPS 1696

Query: 990  WAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039
                +FV+ +     V+ N+ +A+++E F    + +     ED   + +E
Sbjct: 1697 VGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1746



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 41/132 (31%), Positives = 70/132 (53%), Gaps = 13/132 (9%)

Query: 356  NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA----------HSFYNFIYFILLIIV 405
            N  +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II 
Sbjct: 1346 NVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIF 1405

Query: 406  GSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDSTLASFSEPGSCYEELLK 462
            GSFF +NL + VI   F++ K++   +   M E++ ++ +    L S            K
Sbjct: 1406 GSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANK 1465

Query: 463  YVGHIFRKVKRR 474
            + G +F  V R+
Sbjct: 1466 FQGMVFDFVTRQ 1477



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 48/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847
           +I+    FS  IM  IL N + M +     P + T  +E +   FT ++  E L+K+LA 
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176

Query: 848 G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902
           G       ++R+P+N  D  +IV+  V E V    G +S LRTFR+LR LK +  +P L+
Sbjct: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSL--GNVSALRTFRVLRALKTISVIPGLK 234

Query: 903 RQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 937
             +  L++++  ++    L +  + +F+++G+ LF
Sbjct: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 42/157 (26%), Positives = 80/157 (50%), Gaps = 8/157 (5%)

Query: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
           +V +P+ +    + I+LN + + M    E      +  ++L   +      F  EMV+K+
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762

Query: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215
           +A+  +    Y  + WN  D  IV   +ME  L      LS +R+ R+LR  +     P+
Sbjct: 763 IAMDPY---YYFQEGWNIFDGIIVSLSLMELGLSNVE-GLSVLRSFRLLRVFKLAKSWPT 818

Query: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 819 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 855



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 44/198 (22%), Positives = 94/198 (47%), Gaps = 24/198 (12%)

Query: 1604 SPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFE 1663
            +P R+    +       + I   I  N + M++   N P    +  K   Y FT ++ FE
Sbjct: 115  NPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLS--NPP----DWTKNVEYTFTGIYTFE 168

Query: 1664 AALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRV 1719
            + +K++A GF      F +D WN LD ++++++ +   +    +SA           +R 
Sbjct: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSA-----------LRT 217

Query: 1720 LRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFG---RLEC 1776
             R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF    R +C
Sbjct: 218  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC 277

Query: 1777 SEDNPCEGLSRHATFSNF 1794
             +  P +      T S F
Sbjct: 278  LQWPPSDSAFETNTTSYF 295



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 48/159 (30%), Positives = 75/159 (47%), Gaps = 15/159 (9%)

Query: 102  FEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLF 161
            F+   M++I LN VT+ +    E  + G     +L   +      F  E V+K+V+L  +
Sbjct: 1479 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHY 1534

Query: 162  GQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVS---LSAIRTVRVLRPLRAINRVP 214
                Y    WN  DF +V+  ++   L    + + VS      IR  R+ R LR I    
Sbjct: 1535 ----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1590

Query: 215  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1591 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 39/141 (27%), Positives = 65/141 (46%), Gaps = 19/141 (13%)

Query: 1775 ECSEDNPCEGLSR-----HATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCL 1829
            +C E   C    R     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 345  QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGK------ 398

Query: 1830 SYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQGPG 1889
            +Y+     ++FV  + +  F LVN+++AV+    EE N+   E+AE   + E E  Q   
Sbjct: 399  TYM-----IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAE---QKEAEFQQMLE 450

Query: 1890 SARRVDADRPPLPQESPGARD 1910
              ++   +   +   S  +RD
Sbjct: 451  QLKKQQEEAQAVAAASAASRD 471



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 366 YAWIAIFQVITLEGWVDIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 423
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 882 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 939



 Score = 32.7 bits (73), Expect = 4.3
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 360  NFDNIGYAWIAIFQVITLEGWVDIMYYVMDA---------------------HSFYNFIY 398
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 1642 NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFF 1701

Query: 399  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 435
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 1702 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1738


>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
            [Homo sapiens]
          Length = 1951

 Score =  333 bits (855), Expect = 9e-91
 Identities = 206/656 (31%), Positives = 360/656 (54%), Gaps = 45/656 (6%)

Query: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343
            R +C  ++ H  F+  ++  I L+   +A E   I+   T +  L  ++ +FT IF+ EM
Sbjct: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1206

Query: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403
            ++K VA G       Y  ++W  LD L+V VSLV +V   A+A G   LG ++ LR LR 
Sbjct: 1207 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1259

Query: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1463
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFY+C    
Sbjct: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319

Query: 1464 TRN------ISTKAQCRA--AHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLD 1515
            T N      ++  + C+A     RW   K NFDN+G   ++L  +++  GW++IMY  +D
Sbjct: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379

Query: 1516 AVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEA-RRRE 1574
            +  V  QPV   N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++     E
Sbjct: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1439

Query: 1575 EKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITM 1634
            +K+     ++  S  P     ++P     +  +  +    T    D+ I  +IC+N++TM
Sbjct: 1440 QKKYYNAMKKLGSKKP-----QKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTM 1494

Query: 1635 SMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLM 1694
             +E  +Q K +   L   N VF ++F  E  LKLV+     +F   WN  D  +V+LS++
Sbjct: 1495 MVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSIV 1553

Query: 1695 GITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGL 1754
            G+ L   EM     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GL
Sbjct: 1554 GMFL--AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL 1611

Query: 1755 LFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIM 1814
            L  L+ FIYA  G+  F  ++        G+     F  FG + + LF+++T   W+G++
Sbjct: 1612 LLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGLL 1666

Query: 1815 KDTLR----ECSREDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLE 1864
               L     +C  +  H  S +      P++   +FV++++++  V+VN+ +AV++++  
Sbjct: 1667 APILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFS 1726

Query: 1865 ESNKEARED-AELDAEIELEMAQ--GPGSARRVDADRPPLPQESPGARDAPNLVAR 1917
             + +E+ E  +E D E+  E+ +   P + + ++  +     +   A D P L+A+
Sbjct: 1727 VATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSK---LSDFAAALDPPLLIAK 1779



 Score =  141 bits (355), Expect = 9e-33
 Identities = 82/257 (31%), Positives = 143/257 (55%), Gaps = 6/257 (2%)

Query: 779  WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838
            W+     +  IV   +    I + I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 697  WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 756

Query: 839  EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898
            EM+LK++A  P  Y +  +NIFDGIIV +S+ E+      GLSVLR+FRLLRV KL +  
Sbjct: 757  EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 816

Query: 899  PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS---LKTDTGDTVPDRK 955
            P L   + ++  ++  +     +L + +FIF+++GM LFG  +     K +   T+P R 
Sbjct: 817  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 875

Query: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAIL 1014
            + +    + + VF++L  E W   +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 876  HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 934

Query: 1015 VEGFQAEGDANRSDTDE 1031
            +  F ++  A   D +E
Sbjct: 935  LSSFSSDNLAATDDDNE 951



 Score =  132 bits (332), Expect = 4e-30
 Identities = 109/470 (23%), Positives = 204/470 (43%), Gaps = 95/470 (20%)

Query: 76  AATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNI 135
           A +  + L      R   ++++ +  F  + M  I+ NCV + +  P +  +      N+
Sbjct: 104 ATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTK------NV 157

Query: 136 LEAFDAFIFAFFAVEMVIKMVALGLFGQK-CYLGDTWNRLDFFIVVAGMMEYSLDGHNVS 194
              F       +  E +IK++A G   +   +L D WN LDF ++V   +   +D  NVS
Sbjct: 158 EYTFTGI----YTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS 213

Query: 195 LSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254
             A+RT RVLR L+ I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G
Sbjct: 214 --ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271

Query: 255 LLRNRCF----LDSAFVRN----------NNLTFLR---------------PYYQTEEGE 285
            LRN+C      DSAF  N          +N TF+                 ++   +G+
Sbjct: 272 NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331

Query: 286 ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYN 345
           ++P +C +  D G                C  G+                          
Sbjct: 332 KDPLLCGNGSDAGQ---------------CPEGY-------------------------- 350

Query: 346 VCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIV 405
           +C     NP+ G  +FD   +A++++F+++T + W ++    + A      I+F+L+I +
Sbjct: 351 ICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFL 410

Query: 406 GSFFMINLCLVVIATQF----------SETKQRESQLMREQRARHLSNDSTLASFSEPGS 455
           GSF+++NL L V+A  +          +E K+ E Q M EQ  +       +A+ S    
Sbjct: 411 GSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASR 470

Query: 456 CYEEL--LKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHR 503
            +  +  L  +     +  + S +    W++R +K+     ++G   G R
Sbjct: 471 DFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGER 520



 Score =  115 bits (287), Expect = 7e-25
 Identities = 131/634 (20%), Positives = 260/634 (41%), Gaps = 91/634 (14%)

Query: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015
            +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424

Query: 1016 EGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPP 1075
              ++ +  A   + ++ +    F++   +L++ Q  E +  + A   +    G G L   
Sbjct: 425  MAYEEQNQATLEEAEQKEAE--FQQMLEQLKK-QQEEAQAVAAASAASRDFSGIGGLGEL 481

Query: 1076 LIMCTAATPMPTPK--------------------------SSPFLDAAPSLPDSRRGSSS 1109
            L   + A+ + +                            S P  ++  S+  S    S 
Sbjct: 482  LESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSM 541

Query: 1110 SGDPPLGDQK---PPASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESL 1166
             G+    D+K   P  SL S   + + P    +S+ S +S  GRA  +       + E  
Sbjct: 542  DGNRLTSDKKFCSPHQSLLSIRGSLFSPRR--NSKTSIFSFRGRAKDVGSENDFADDEHS 599

Query: 1167 LSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPS 1226
               + +   D      R      +        +  R L    +      D  G+  A+  
Sbjct: 600  TFEDSESRRDSLFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVS- 658

Query: 1227 DFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALY-LFSPQNRFRV 1285
                 I S   +  E  ++S   C            P W R    + ++       + + 
Sbjct: 659  -----IASILTNTMEELEESRQKC-----------PPCWYRFANVFLIWDCCDAWLKVKH 702

Query: 1286 SCQKVITHKMFDHVVLVFIFLNCVTIALER-PDIDPGSTERVFLSVSNYIFTAIFVAEMM 1344
                ++     D  + + I LN + +A+E  P  +  S+    L+V N +FT IF AEM+
Sbjct: 703  LVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMV 759

Query: 1345 VKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTL 1404
            +K++A+      + Y Q  WN+ DG++V +SL+++        G   +  L VLR  R L
Sbjct: 760  LKIIAMD----PYYYFQEGWNIFDGIIVSLSLMEL--------GLSNVEGLSVLRSFRLL 807

Query: 1405 RPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDT 1464
            R  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF GK Y       
Sbjct: 808  RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY------- 859

Query: 1465 RNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPV 1524
                 +  C+      + R +  D     L+   VL  +  W+  M+D ++  G      
Sbjct: 860  ----KECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE--WIETMWDCMEVAG------ 907

Query: 1525 QNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558
                   L+ F+  ++I +  VLN+F+ +++ +F
Sbjct: 908  ---QTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938



 Score =  109 bits (272), Expect = 4e-23
 Identities = 75/260 (28%), Positives = 128/260 (49%), Gaps = 27/260 (10%)

Query: 1618 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1677
            ++DL IT  I +N + M+MEHY   +     L   N VFT +F  E  LK++A     +F
Sbjct: 712  FVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYF 771

Query: 1678 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1737
            ++ WN  D  IV LSLM + L  +E           + ++R  R+ RV KL K    +  
Sbjct: 772  QEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKLAKSWPTLNM 821

Query: 1738 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR----LECSEDNPCEGLSRHATFSN 1793
            L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      C  ++ C     H   ++
Sbjct: 822  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWH--MND 879

Query: 1794 FGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1853
            F  +FL +FRV  G+ W   M D +    +    CL        + F+  +++   V++N
Sbjct: 880  FFHSFLIVFRVLCGE-WIETMWDCMEVAGQ--TMCL--------IVFMLVMVIGNLVVLN 928

Query: 1854 VVVAVLMKHLEESNKEARED 1873
            + +A+L+      N  A +D
Sbjct: 929  LFLALLLSSFSSDNLAATDD 948



 Score =  106 bits (265), Expect = 2e-22
 Identities = 76/291 (26%), Positives = 138/291 (47%), Gaps = 38/291 (13%)

Query: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338
            P N+F+      +T ++FD  +++ I LN VT+ +E    D G    + LS  N +F  +
Sbjct: 1462 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1519

Query: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398
            F  E ++K+V+L      H Y    WN+ D ++V++S+V + +A           + RV+
Sbjct: 1520 FTGEFVLKLVSL-----RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1574

Query: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1575 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1628

Query: 1459 CEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518
                                  +   +NF+  G +++ LF +++  GW  ++   L++  
Sbjct: 1629 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1674

Query: 1519 VDQQPVQNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1558
             D  P   H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1675 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1725



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 79/280 (28%), Positives = 128/280 (45%), Gaps = 28/280 (10%)

Query: 1186 PGPRATPLRRAESL---DPRPLRPAALPPTKCRDRDGQVVALP-SDF-------FLRIDS 1234
            PGP +  L   ESL   + R     A  P K +D D +    P SD        F+  D 
Sbjct: 9    PGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDI 68

Query: 1235 HREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHK 1294
              E  +E  +D +     +   ++        R     ALY+ +P N  R    K++ H 
Sbjct: 69   PPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHS 128

Query: 1295 MFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLS 1354
            +F  +++  I  NCV + L  P   P  T+ V      Y FT I+  E ++K++A G   
Sbjct: 129  LFSMLIMCTILTNCVFMTLSNP---PDWTKNV-----EYTFTGIYTFESLIKILARGFCL 180

Query: 1355 GEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAP 1414
             +  +L+  WN LD  +++++ V   V          LG +  LR  R LR L+ IS  P
Sbjct: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGNVSALRTFRVLRALKTISVIP 231

Query: 1415 GLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKG 1454
            GLK +V  LI S++ + +++++      +F ++G+QLF G
Sbjct: 232  GLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 74/286 (25%), Positives = 133/286 (46%), Gaps = 40/286 (13%)

Query: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833
            G++W         IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT
Sbjct: 1140 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1199

Query: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA-----DGGLSVLRTFRL 888
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V  A      G +  LRT R 
Sbjct: 1200 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1259

Query: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKF----SLK 944
            LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  KF    ++ 
Sbjct: 1260 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1319

Query: 945  TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 985
            T     + D                   + NFD++    + + Q+ T + W  ++Y  + 
Sbjct: 1320 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1379

Query: 986  S----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
            S           + +  LYFV  + FG++   NL + ++++ F  +
Sbjct: 1380 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1425



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 61/174 (35%), Positives = 93/174 (53%), Gaps = 19/174 (10%)

Query: 90   RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFF 147
            R  C  +V + WFE   + +I+L+   L      ED+     +    +LE  D      F
Sbjct: 1147 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1202

Query: 148  AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAIRT 200
             +EM++K VA   +G + Y  + W  LDF IV       VA  + YS  G   ++ ++RT
Sbjct: 1203 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELG---AIKSLRT 1256

Query: 201  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 1257 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 73/290 (25%), Positives = 131/290 (45%), Gaps = 41/290 (14%)

Query: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841
            F G +   V  + F   IM+ I +N ++M VE  +Q + +T  L   N+VF  +F  E +
Sbjct: 1466 FQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFV 1525

Query: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQ-----------ADGGLSVLRTFRLLR 890
            LKL++     Y    +NIFD ++V++S   IVG            +     V+R  R+ R
Sbjct: 1526 LKLVSLRHY-YFTIGWNIFDFVVVILS---IVGMFLAEMIEKYFVSPTLFRVIRLARIGR 1581

Query: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950
            +L+L++    +R  L  L+ ++  +     LL L +FI++I GM  F     +K + G  
Sbjct: 1582 ILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG-- 1636

Query: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL---------------------YNGMASTSS 989
            + D  NF++   +++ +FQI T   W+ +L                       G     S
Sbjct: 1637 IDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPS 1696

Query: 990  WAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039
                +FV+ +     V+ N+ +A+++E F    + +     ED   + +E
Sbjct: 1697 VGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1746



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 41/132 (31%), Positives = 70/132 (53%), Gaps = 13/132 (9%)

Query: 356  NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA----------HSFYNFIYFILLIIV 405
            N  +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II 
Sbjct: 1346 NVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIF 1405

Query: 406  GSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDSTLASFSEPGSCYEELLK 462
            GSFF +NL + VI   F++ K++   +   M E++ ++ +    L S            K
Sbjct: 1406 GSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANK 1465

Query: 463  YVGHIFRKVKRR 474
            + G +F  V R+
Sbjct: 1466 FQGMVFDFVTRQ 1477



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 48/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847
           +I+    FS  IM  IL N + M +     P + T  +E +   FT ++  E L+K+LA 
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176

Query: 848 G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902
           G       ++R+P+N  D  +IV+  V E V    G +S LRTFR+LR LK +  +P L+
Sbjct: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234

Query: 903 RQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 937
             +  L++++  ++    L +  + +F+++G+ LF
Sbjct: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 42/157 (26%), Positives = 80/157 (50%), Gaps = 8/157 (5%)

Query: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
           +V +P+ +    + I+LN + + M    E      +  ++L   +      F  EMV+K+
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 762

Query: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215
           +A+  +    Y  + WN  D  IV   +ME  L      LS +R+ R+LR  +     P+
Sbjct: 763 IAMDPY---YYFQEGWNIFDGIIVSLSLMELGLSNVE-GLSVLRSFRLLRVFKLAKSWPT 818

Query: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 819 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 855



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 44/198 (22%), Positives = 95/198 (47%), Gaps = 24/198 (12%)

Query: 1604 SPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFE 1663
            +P R+    +       + I   I  N + M++   N P    +  K   Y FT ++ FE
Sbjct: 115  NPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLS--NPP----DWTKNVEYTFTGIYTFE 168

Query: 1664 AALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRV 1719
            + +K++A GF      F +D WN LD ++++++ +   ++   +SA           +R 
Sbjct: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA-----------LRT 217

Query: 1720 LRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFG---RLEC 1776
             R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF    R +C
Sbjct: 218  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC 277

Query: 1777 SEDNPCEGLSRHATFSNF 1794
             +  P +      T S F
Sbjct: 278  LQWPPSDSAFETNTTSYF 295



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 48/159 (30%), Positives = 75/159 (47%), Gaps = 15/159 (9%)

Query: 102  FEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLF 161
            F+   M++I LN VT+ +    E  + G     +L   +      F  E V+K+V+L  +
Sbjct: 1479 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHY 1534

Query: 162  GQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVS---LSAIRTVRVLRPLRAINRVP 214
                Y    WN  DF +V+  ++   L    + + VS      IR  R+ R LR I    
Sbjct: 1535 ----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1590

Query: 215  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1591 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1629



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 39/141 (27%), Positives = 65/141 (46%), Gaps = 19/141 (13%)

Query: 1775 ECSEDNPCEGLSR-----HATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCL 1829
            +C E   C    R     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 345  QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGK------ 398

Query: 1830 SYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQGPG 1889
            +Y+     ++FV  + +  F LVN+++AV+    EE N+   E+AE   + E E  Q   
Sbjct: 399  TYM-----IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAE---QKEAEFQQMLE 450

Query: 1890 SARRVDADRPPLPQESPGARD 1910
              ++   +   +   S  +RD
Sbjct: 451  QLKKQQEEAQAVAAASAASRD 471



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 366 YAWIAIFQVITLEGWVDIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 423
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 882 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 939



 Score = 32.7 bits (73), Expect = 4.3
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 360  NFDNIGYAWIAIFQVITLEGWVDIMYYVMDA---------------------HSFYNFIY 398
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 1642 NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFF 1701

Query: 399  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 435
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 1702 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1738


>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
            [Homo sapiens]
          Length = 2000

 Score =  333 bits (855), Expect = 9e-91
 Identities = 206/656 (31%), Positives = 360/656 (54%), Gaps = 45/656 (6%)

Query: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343
            R +C  ++ H  F+  ++  I L+   +A E   I+   T +  L  ++ +FT IF+ EM
Sbjct: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1255

Query: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403
            ++K VA G       Y  ++W  LD L+V VSLV +V   A+A G   LG ++ LR LR 
Sbjct: 1256 LLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLV---ANALGYSELGAIKSLRTLRA 1308

Query: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1463
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFY+C    
Sbjct: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368

Query: 1464 TRN------ISTKAQCRA--AHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLD 1515
            T N      ++  + C+A     RW   K NFDN+G   ++L  +++  GW++IMY  +D
Sbjct: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428

Query: 1516 AVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEA-RRRE 1574
            +  V  QPV   N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++     E
Sbjct: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1488

Query: 1575 EKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITM 1634
            +K+     ++  S  P     ++P     +  +  +    T    D+ I  +IC+N++TM
Sbjct: 1489 QKKYYNAMKKLGSKKP-----QKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTM 1543

Query: 1635 SMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLM 1694
             +E  +Q K +   L   N VF ++F  E  LKLV+     +F   WN  D  +V+LS++
Sbjct: 1544 MVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSIV 1602

Query: 1695 GITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGL 1754
            G+ L   EM     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GL
Sbjct: 1603 GMFL--AEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGL 1660

Query: 1755 LFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIM 1814
            L  L+ FIYA  G+  F  ++        G+     F  FG + + LF+++T   W+G++
Sbjct: 1661 LLFLVMFIYAIFGMSNFAYVKKE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGLL 1715

Query: 1815 KDTLR----ECSREDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLE 1864
               L     +C  +  H  S +      P++   +FV++++++  V+VN+ +AV++++  
Sbjct: 1716 APILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFS 1775

Query: 1865 ESNKEARED-AELDAEIELEMAQ--GPGSARRVDADRPPLPQESPGARDAPNLVAR 1917
             + +E+ E  +E D E+  E+ +   P + + ++  +     +   A D P L+A+
Sbjct: 1776 VATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSK---LSDFAAALDPPLLIAK 1828



 Score =  141 bits (355), Expect = 9e-33
 Identities = 82/257 (31%), Positives = 143/257 (55%), Gaps = 6/257 (2%)

Query: 779  WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838
            W+     +  IV   +    I + I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 746  WLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTA 805

Query: 839  EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898
            EM+LK++A  P  Y +  +NIFDGIIV +S+ E+      GLSVLR+FRLLRV KL +  
Sbjct: 806  EMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSW 865

Query: 899  PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS---LKTDTGDTVPDRK 955
            P L   + ++  ++  +     +L + +FIF+++GM LFG  +     K +   T+P R 
Sbjct: 866  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLP-RW 924

Query: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAIL 1014
            + +    + + VF++L  E W   +++ M  +  +   + F+ +M  GN V+ NL +A+L
Sbjct: 925  HMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALL 983

Query: 1015 VEGFQAEGDANRSDTDE 1031
            +  F ++  A   D +E
Sbjct: 984  LSSFSSDNLAATDDDNE 1000



 Score =  132 bits (332), Expect = 4e-30
 Identities = 109/470 (23%), Positives = 204/470 (43%), Gaps = 95/470 (20%)

Query: 76  AATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNI 135
           A +  + L      R   ++++ +  F  + M  I+ NCV + +  P +  +      N+
Sbjct: 104 ATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTK------NV 157

Query: 136 LEAFDAFIFAFFAVEMVIKMVALGLFGQK-CYLGDTWNRLDFFIVVAGMMEYSLDGHNVS 194
              F       +  E +IK++A G   +   +L D WN LDF ++V   +   +D  NVS
Sbjct: 158 EYTFTGI----YTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVS 213

Query: 195 LSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254
             A+RT RVLR L+ I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G
Sbjct: 214 --ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271

Query: 255 LLRNRCF----LDSAFVRN----------NNLTFLR---------------PYYQTEEGE 285
            LRN+C      DSAF  N          +N TF+                 ++   +G+
Sbjct: 272 NLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQ 331

Query: 286 ENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYN 345
           ++P +C +  D G                C  G+                          
Sbjct: 332 KDPLLCGNGSDAGQ---------------CPEGY-------------------------- 350

Query: 346 VCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIV 405
           +C     NP+ G  +FD   +A++++F+++T + W ++    + A      I+F+L+I +
Sbjct: 351 ICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFL 410

Query: 406 GSFFMINLCLVVIATQF----------SETKQRESQLMREQRARHLSNDSTLASFSEPGS 455
           GSF+++NL L V+A  +          +E K+ E Q M EQ  +       +A+ S    
Sbjct: 411 GSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASR 470

Query: 456 CYEEL--LKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQGPGHR 503
            +  +  L  +     +  + S +    W++R +K+     ++G   G R
Sbjct: 471 DFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGER 520



 Score =  113 bits (282), Expect = 3e-24
 Identities = 143/670 (21%), Positives = 277/670 (41%), Gaps = 114/670 (17%)

Query: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015
            +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 365  SFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVA 424

Query: 1016 EGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPP 1075
              ++ +  A   + ++ +    F++   +L++ Q  E +  + A   +    G G L   
Sbjct: 425  MAYEEQNQATLEEAEQKEAE--FQQMLEQLKK-QQEEAQAVAAASAASRDFSGIGGLGEL 481

Query: 1076 LIMCTAATPMPTPK--------------------------SSPFLDAAPSLPDSRRGSSS 1109
            L   + A+ + +                            S P  ++  S+  S    S 
Sbjct: 482  LESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSM 541

Query: 1110 SGDPPLGDQK---PPASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGE---- 1162
             G+    D+K   P  SL S   + + P    +S+ S +S  GRA  +       +    
Sbjct: 542  DGNRLTSDKKFCSPHQSLLSIRGSLFSPRR--NSKTSIFSFRGRAKDVGSENDFADDEHS 599

Query: 1163 --------RESLL----SGEGKGSTDDEAE-DGRAAPGPRATPLRRAESLDPRPLRPAAL 1209
                    R+SL      GE + S   +A    R  PG  A   +   ++D   +     
Sbjct: 600  TFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANG-KMHSTVDCNGVVSLVG 658

Query: 1210 PPTKCRDRDGQVVALPSDFFL--------RIDSHREDAAELDDDSEDSCCLRLHKVLEPY 1261
             P+      GQ   LP +           R+ S++     L+D S     + +  +L   
Sbjct: 659  GPSALTSPTGQ---LPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNT 715

Query: 1262 KPQWCRSREAWALYLFSPQNRFRV--SCQK----------VITHKMFDHVVLVFIFLNCV 1309
              +   SR+      +   N F +   C            ++     D  + + I LN +
Sbjct: 716  MEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTL 775

Query: 1310 TIALER-PDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLD 1368
             +A+E  P  +  S+    L+V N +FT IF AEM++K++A+      + Y Q  WN+ D
Sbjct: 776  FMAMEHYPMTEQFSS---VLTVGNLVFTGIFTAEMVLKIIAMD----PYYYFQEGWNIFD 828

Query: 1369 GLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLR 1428
            G++V +SL+++        G   +  L VLR  R LR  ++    P L ++++ + +S+ 
Sbjct: 829  GIIVSLSLMEL--------GLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 880

Query: 1429 PIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQCRAAHYRWVRRKYNFD 1488
             +GN+ L+      IF ++G+QLF GK Y            +  C+      + R +  D
Sbjct: 881  ALGNLTLVLAIIVFIFAVVGMQLF-GKSY-----------KECVCKINDDCTLPRWHMND 928

Query: 1489 NLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLN 1548
                 L+   VL  +  W+  M+D ++  G             L+ F+  ++I +  VLN
Sbjct: 929  FFHSFLIVFRVLCGE--WIETMWDCMEVAG---------QTMCLIVFMLVMVIGNLVVLN 977

Query: 1549 MFVGVVVENF 1558
            +F+ +++ +F
Sbjct: 978  LFLALLLSSF 987



 Score =  109 bits (272), Expect = 4e-23
 Identities = 75/260 (28%), Positives = 128/260 (49%), Gaps = 27/260 (10%)

Query: 1618 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1677
            ++DL IT  I +N + M+MEHY   +     L   N VFT +F  E  LK++A     +F
Sbjct: 761  FVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYF 820

Query: 1678 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1737
            ++ WN  D  IV LSLM + L  +E           + ++R  R+ RV KL K    +  
Sbjct: 821  QEGWNIFDGIIVSLSLMELGLSNVEG----------LSVLRSFRLLRVFKLAKSWPTLNM 870

Query: 1738 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR----LECSEDNPCEGLSRHATFSN 1793
            L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      C  ++ C     H   ++
Sbjct: 871  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWH--MND 928

Query: 1794 FGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1853
            F  +FL +FRV  G+ W   M D +    +    CL        + F+  +++   V++N
Sbjct: 929  FFHSFLIVFRVLCGE-WIETMWDCMEVAGQ--TMCL--------IVFMLVMVIGNLVVLN 977

Query: 1854 VVVAVLMKHLEESNKEARED 1873
            + +A+L+      N  A +D
Sbjct: 978  LFLALLLSSFSSDNLAATDD 997



 Score =  106 bits (265), Expect = 2e-22
 Identities = 76/291 (26%), Positives = 138/291 (47%), Gaps = 38/291 (13%)

Query: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338
            P N+F+      +T ++FD  +++ I LN VT+ +E    D G    + LS  N +F  +
Sbjct: 1511 PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETD--DQGKYMTLVLSRINLVFIVL 1568

Query: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398
            F  E ++K+V+L      H Y    WN+ D ++V++S+V + +A           + RV+
Sbjct: 1569 FTGEFVLKLVSL-----RHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVI 1623

Query: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1624 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF------ 1677

Query: 1459 CEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518
                                  +   +NF+  G +++ LF +++  GW  ++   L++  
Sbjct: 1678 --------------AYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAP 1723

Query: 1519 VDQQPVQNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1558
             D  P   H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1724 PDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1774



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 79/280 (28%), Positives = 128/280 (45%), Gaps = 28/280 (10%)

Query: 1186 PGPRATPLRRAESL---DPRPLRPAALPPTKCRDRDGQVVALP-SDF-------FLRIDS 1234
            PGP +  L   ESL   + R     A  P K +D D +    P SD        F+  D 
Sbjct: 9    PGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDI 68

Query: 1235 HREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHK 1294
              E  +E  +D +     +   ++        R     ALY+ +P N  R    K++ H 
Sbjct: 69   PPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHS 128

Query: 1295 MFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLS 1354
            +F  +++  I  NCV + L  P   P  T+ V      Y FT I+  E ++K++A G   
Sbjct: 129  LFSMLIMCTILTNCVFMTLSNP---PDWTKNV-----EYTFTGIYTFESLIKILARGFCL 180

Query: 1355 GEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAP 1414
             +  +L+  WN LD  +++++ V   V          LG +  LR  R LR L+ IS  P
Sbjct: 181  EDFTFLRDPWNWLDFSVIVMAYVTEFVD---------LGNVSALRTFRVLRALKTISVIP 231

Query: 1415 GLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKG 1454
            GLK +V  LI S++ + +++++      +F ++G+QLF G
Sbjct: 232  GLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 74/286 (25%), Positives = 133/286 (46%), Gaps = 40/286 (13%)

Query: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833
            G++W         IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT
Sbjct: 1189 GKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1248

Query: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA-----DGGLSVLRTFRL 888
             +F LEMLLK +A G   Y  N +   D +IV +S+  +V  A      G +  LRT R 
Sbjct: 1249 YIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRA 1308

Query: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKF----SLK 944
            LR L+ +     +R  +  LV  + ++     + ++F  IFSI+G++LF  KF    ++ 
Sbjct: 1309 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMT 1368

Query: 945  TDTGDTVPD-------------------RKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA 985
            T     + D                   + NFD++    + + Q+ T + W  ++Y  + 
Sbjct: 1369 TGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1428

Query: 986  S----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
            S           + +  LYFV  + FG++   NL + ++++ F  +
Sbjct: 1429 SRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1474



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 61/174 (35%), Positives = 93/174 (53%), Gaps = 19/174 (10%)

Query: 90   RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFF 147
            R  C  +V + WFE   + +I+L+   L      ED+     +    +LE  D      F
Sbjct: 1196 RKTCYSIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1251

Query: 148  AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMMEYSLDGHNVSLSAIRT 200
             +EM++K VA   +G + Y  + W  LDF IV       VA  + YS  G   ++ ++RT
Sbjct: 1252 ILEMLLKWVA---YGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELG---AIKSLRT 1305

Query: 201  VRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254
            +R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 1306 LRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1359



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 73/290 (25%), Positives = 131/290 (45%), Gaps = 41/290 (14%)

Query: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841
            F G +   V  + F   IM+ I +N ++M VE  +Q + +T  L   N+VF  +F  E +
Sbjct: 1515 FQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFV 1574

Query: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQ-----------ADGGLSVLRTFRLLR 890
            LKL++     Y    +NIFD ++V++S   IVG            +     V+R  R+ R
Sbjct: 1575 LKLVSLRHY-YFTIGWNIFDFVVVILS---IVGMFLAEMIEKYFVSPTLFRVIRLARIGR 1630

Query: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950
            +L+L++    +R  L  L+ ++  +     LL L +FI++I GM  F     +K + G  
Sbjct: 1631 ILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKKEAG-- 1685

Query: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL---------------------YNGMASTSS 989
            + D  NF++   +++ +FQI T   W+ +L                       G     S
Sbjct: 1686 IDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPS 1745

Query: 990  WAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039
                +FV+ +     V+ N+ +A+++E F    + +     ED   + +E
Sbjct: 1746 VGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1795



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 41/132 (31%), Positives = 70/132 (53%), Gaps = 13/132 (9%)

Query: 356  NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA----------HSFYNFIYFILLIIV 405
            N  +NFDN+G  ++A+ QV T +GW+DIMY  +D+           + Y ++YF++ II 
Sbjct: 1395 NVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIF 1454

Query: 406  GSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDSTLASFSEPGSCYEELLK 462
            GSFF +NL + VI   F++ K++   +   M E++ ++ +    L S            K
Sbjct: 1455 GSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANK 1514

Query: 463  YVGHIFRKVKRR 474
            + G +F  V R+
Sbjct: 1515 FQGMVFDFVTRQ 1526



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 48/155 (30%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847
           +I+    FS  IM  IL N + M +     P + T  +E +   FT ++  E L+K+LA 
Sbjct: 123 KILVHSLFSMLIMCTILTNCVFMTLS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 176

Query: 848 G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902
           G       ++R+P+N  D  +IV+  V E V    G +S LRTFR+LR LK +  +P L+
Sbjct: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 234

Query: 903 RQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 937
             +  L++++  ++    L +  + +F+++G+ LF
Sbjct: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 269



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 42/157 (26%), Positives = 80/157 (50%), Gaps = 8/157 (5%)

Query: 96  LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
           +V +P+ +    + I+LN + + M    E      +  ++L   +      F  EMV+K+
Sbjct: 756 IVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI 811

Query: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215
           +A+  +    Y  + WN  D  IV   +ME  L      LS +R+ R+LR  +     P+
Sbjct: 812 IAMDPY---YYFQEGWNIFDGIIVSLSLMELGLSNVE-GLSVLRSFRLLRVFKLAKSWPT 867

Query: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 868 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 904



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 44/198 (22%), Positives = 95/198 (47%), Gaps = 24/198 (12%)

Query: 1604 SPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFE 1663
            +P R+    +       + I   I  N + M++   N P    +  K   Y FT ++ FE
Sbjct: 115  NPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLS--NPP----DWTKNVEYTFTGIYTFE 168

Query: 1664 AALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRV 1719
            + +K++A GF      F +D WN LD ++++++ +   ++   +SA           +R 
Sbjct: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSA-----------LRT 217

Query: 1720 LRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFG---RLEC 1776
             R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF    R +C
Sbjct: 218  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC 277

Query: 1777 SEDNPCEGLSRHATFSNF 1794
             +  P +      T S F
Sbjct: 278  LQWPPSDSAFETNTTSYF 295



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 48/159 (30%), Positives = 75/159 (47%), Gaps = 15/159 (9%)

Query: 102  FEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLF 161
            F+   M++I LN VT+ +    E  + G     +L   +      F  E V+K+V+L  +
Sbjct: 1528 FDISIMILICLNMVTMMV----ETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHY 1583

Query: 162  GQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVS---LSAIRTVRVLRPLRAINRVP 214
                Y    WN  DF +V+  ++   L    + + VS      IR  R+ R LR I    
Sbjct: 1584 ----YFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1639

Query: 215  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1640 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1678



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 39/141 (27%), Positives = 65/141 (46%), Gaps = 19/141 (13%)

Query: 1775 ECSEDNPCEGLSR-----HATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCL 1829
            +C E   C    R     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 345  QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGK------ 398

Query: 1830 SYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQGPG 1889
            +Y+     ++FV  + +  F LVN+++AV+    EE N+   E+AE   + E E  Q   
Sbjct: 399  TYM-----IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAE---QKEAEFQQMLE 450

Query: 1890 SARRVDADRPPLPQESPGARD 1910
              ++   +   +   S  +RD
Sbjct: 451  QLKKQQEEAQAVAAASAASRD 471



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 16/59 (27%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 366 YAWIAIFQVITLEGWVDIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 423
           ++++ +F+V+  E W++ M+  M+ A      I F+L++++G+  ++NL L ++ + FS
Sbjct: 931 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFS 988



 Score = 32.7 bits (73), Expect = 4.3
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 360  NFDNIGYAWIAIFQVITLEGWVDIMYYVMDA---------------------HSFYNFIY 398
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 1691 NFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFF 1750

Query: 399  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 435
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 1751 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1787


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 106,422,536
Number of Sequences: 37866
Number of extensions: 6149761
Number of successful extensions: 48956
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 214
Number of HSP's successfully gapped in prelim test: 967
Number of HSP's that attempted gapping in prelim test: 33105
Number of HSP's gapped (non-prelim): 11952
length of query: 2353
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2234
effective length of database: 13,741,464
effective search space: 30698430576
effective search space used: 30698430576
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.