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Search of human proteins with 52138747
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|52138747 ankyrin repeat domain 34B [Homo sapiens]
(514 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|52138747 ankyrin repeat domain 34B [Homo sapiens] 1025 0.0
gi|226437606 ankyrin repeat domain 34C [Homo sapiens] 371 e-102
gi|239756364 PREDICTED: ankyrin repeat domain 34C [Homo sapiens] 371 e-102
gi|239750889 PREDICTED: ankyrin repeat domain 34C [Homo sapiens] 371 e-102
gi|239745252 PREDICTED: ankyrin repeat domain 34C [Homo sapiens] 371 e-102
gi|89941470 ankyrin repeat domain 34 [Homo sapiens] 266 3e-71
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 69 1e-11
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 69 1e-11
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 69 1e-11
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 69 1e-11
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 69 1e-11
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 69 1e-11
gi|30348954 mindbomb homolog 1 [Homo sapiens] 65 2e-10
gi|17864094 feminization 1 homolog a [Homo sapiens] 62 1e-09
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 62 1e-09
gi|67906195 ankyrin repeat and sterile alpha motif domain contai... 62 2e-09
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 62 2e-09
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 61 2e-09
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 61 2e-09
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 61 3e-09
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 59 8e-09
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 59 8e-09
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 59 1e-08
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 59 1e-08
gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain ... 58 2e-08
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 58 2e-08
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 58 2e-08
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 58 2e-08
gi|209977003 ANKRD26-like family C, member 3 [Homo sapiens] 57 3e-08
gi|212549546 ANKRD26-like family B, member 2 [Homo sapiens] 57 3e-08
>gi|52138747 ankyrin repeat domain 34B [Homo sapiens]
Length = 514
Score = 1025 bits (2651), Expect = 0.0
Identities = 514/514 (100%), Positives = 514/514 (100%)
Query: 1 MDEGMEISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQS 60
MDEGMEISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQS
Sbjct: 1 MDEGMEISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQS 60
Query: 61 VSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYS 120
VSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYS
Sbjct: 61 VSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYS 120
Query: 121 ALVYAINSEDTETLKVLLSACKAKGKEVIIITTAKSPCGKHTTKQYLNMPPVDIDGCHSP 180
ALVYAINSEDTETLKVLLSACKAKGKEVIIITTAKSPCGKHTTKQYLNMPPVDIDGCHSP
Sbjct: 121 ALVYAINSEDTETLKVLLSACKAKGKEVIIITTAKSPCGKHTTKQYLNMPPVDIDGCHSP 180
Query: 181 ATCTTPSEIDIKTASSPLSHSSETELTLFGFKDLELAGSNDDTWDPGSPVRKPALAPKGP 240
ATCTTPSEIDIKTASSPLSHSSETELTLFGFKDLELAGSNDDTWDPGSPVRKPALAPKGP
Sbjct: 181 ATCTTPSEIDIKTASSPLSHSSETELTLFGFKDLELAGSNDDTWDPGSPVRKPALAPKGP 240
Query: 241 KLPHAPPWVKSPPLLMHQNRVASLQEELQDITPEEELSYKTNGLALSKRFITRHQSIDVK 300
KLPHAPPWVKSPPLLMHQNRVASLQEELQDITPEEELSYKTNGLALSKRFITRHQSIDVK
Sbjct: 241 KLPHAPPWVKSPPLLMHQNRVASLQEELQDITPEEELSYKTNGLALSKRFITRHQSIDVK 300
Query: 301 DTAHLLRAFDQASSRKMSYDEINCQSYLSEGNQQCIEVPVDQDPDSNQTIFASTLRSIVQ 360
DTAHLLRAFDQASSRKMSYDEINCQSYLSEGNQQCIEVPVDQDPDSNQTIFASTLRSIVQ
Sbjct: 301 DTAHLLRAFDQASSRKMSYDEINCQSYLSEGNQQCIEVPVDQDPDSNQTIFASTLRSIVQ 360
Query: 361 KRNLGANHYSSDSQLSAGLTPPTSEDGKALIGKKKILSPSPSQLSESKELLENIPPGPLS 420
KRNLGANHYSSDSQLSAGLTPPTSEDGKALIGKKKILSPSPSQLSESKELLENIPPGPLS
Sbjct: 361 KRNLGANHYSSDSQLSAGLTPPTSEDGKALIGKKKILSPSPSQLSESKELLENIPPGPLS 420
Query: 421 RRNHAVLEGRGSGAFPLDHSVTQTRQGFLPPLNVNSHPPISDINVNNKICSLLSCGQKVL 480
RRNHAVLEGRGSGAFPLDHSVTQTRQGFLPPLNVNSHPPISDINVNNKICSLLSCGQKVL
Sbjct: 421 RRNHAVLEGRGSGAFPLDHSVTQTRQGFLPPLNVNSHPPISDINVNNKICSLLSCGQKVL 480
Query: 481 MPTVPIFPKEFKSKKMLLRRQSLQTEQIKQLVNF 514
MPTVPIFPKEFKSKKMLLRRQSLQTEQIKQLVNF
Sbjct: 481 MPTVPIFPKEFKSKKMLLRRQSLQTEQIKQLVNF 514
>gi|226437606 ankyrin repeat domain 34C [Homo sapiens]
Length = 535
Score = 371 bits (952), Expect = e-102
Identities = 239/537 (44%), Positives = 318/537 (59%), Gaps = 31/537 (5%)
Query: 1 MDEGMEISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQS 60
MD+ E+ ++GNSL+KAV RLRLTRLLLEGGAYINESND+GET LM+AC TKHVD QS
Sbjct: 2 MDDDTELRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQS 61
Query: 61 VSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYS 120
+SK+KMVKYLL+N ADPNIQDKSGKTAL+HAC+ +AG EVVSLLL++GAD SL+D + S
Sbjct: 62 ISKSKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGAS 121
Query: 121 ALVYAINSEDTETLKVLLSACKAKGKEVIIITTAKSPCGKHTTKQYLNMPP-VDIDGCHS 179
ALVYAIN++D + LK LL ACKAKGKEVIIITT KS G TTKQYLN+PP ++ HS
Sbjct: 122 ALVYAINADDKDALKHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKVEDRHS 181
Query: 180 PATCTTPSEIDIKT--ASSPLSHSSETELTLFGFKDLELAGSNDDTWDPGSPVR-----K 232
P C +PS+I++K SPL+ + +L ++ +PGSP R K
Sbjct: 182 PPLCASPSDIELKALGLDSPLTEKEDDFFSLQAGHP-SSCNTSKAVNEPGSPTRKVSNLK 240
Query: 233 PALAPKGPKLPHAPPWVKSPPLLMHQNRVASLQEELQDITPEEELSYKTNGLALSKRF-I 291
A P+ +L P + +P +L R Q+E + + E+ + ++ KR +
Sbjct: 241 RARLPQLKRLQSEPWGLIAPSVLAASTR----QDETHGASTDNEVIKSISDISFPKRGPL 296
Query: 292 TRHQSIDVKDTAHLLRAFDQASSRKMSYDEINCQSYLSEGN------QQCIEVPVDQDPD 345
+R SID KD +Q +S + ++ +G + +PVDQ+
Sbjct: 297 SRTNSIDSKDPTLFHTVTEQVLKIPVSSAPASWKAAYEKGQAPHPRLARRGTLPVDQEKC 356
Query: 346 SNQTIFASTLRSIVQKRNLGANHYSSDSQLSAGLTPPTS---EDGKALIGKKKILSPSPS 402
S L+ + L + Y D Q G PP S E GK + +KK+ S S
Sbjct: 357 GMGPSGPSALKEPASLKWLENDLYDLDIQ--PGPDPPNSISLESGKGPLDRKKLNSSHLS 414
Query: 403 QLSESKELLENIP---PGPLSRRNHAVLEGRGSGAFPLDHSVTQTRQGFLPPLNVNSHPP 459
S+E L+ +P P RR +LE RGSG LD ++ TR GFLPPLNVN +PP
Sbjct: 415 LFHGSRESLDTVPSTSPSSARRRPPHLLERRGSGTLLLDR-ISHTRPGFLPPLNVNLNPP 473
Query: 460 ISDINVNNKICSLLSCGQKVLMPTVPIFPK--EFKSKKMLLRRQSLQTEQIKQLVNF 514
I DI ++K L+ G K ++P P PK + +SKK LLRR S+Q EQ+KQL +F
Sbjct: 474 IPDIRSSSKPSCSLASGLKSMVPVAPSSPKRVDLRSKKKLLRRHSMQIEQMKQLSDF 530
>gi|239756364 PREDICTED: ankyrin repeat domain 34C [Homo sapiens]
Length = 534
Score = 371 bits (952), Expect = e-102
Identities = 239/537 (44%), Positives = 318/537 (59%), Gaps = 31/537 (5%)
Query: 1 MDEGMEISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQS 60
MD+ E+ ++GNSL+KAV RLRLTRLLLEGGAYINESND+GET LM+AC TKHVD QS
Sbjct: 1 MDDDTELRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQS 60
Query: 61 VSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYS 120
+SK+KMVKYLL+N ADPNIQDKSGKTAL+HAC+ +AG EVVSLLL++GAD SL+D + S
Sbjct: 61 ISKSKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGAS 120
Query: 121 ALVYAINSEDTETLKVLLSACKAKGKEVIIITTAKSPCGKHTTKQYLNMPP-VDIDGCHS 179
ALVYAIN++D + LK LL ACKAKGKEVIIITT KS G TTKQYLN+PP ++ HS
Sbjct: 121 ALVYAINADDKDALKHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKVEDRHS 180
Query: 180 PATCTTPSEIDIKT--ASSPLSHSSETELTLFGFKDLELAGSNDDTWDPGSPVR-----K 232
P C +PS+I++K SPL+ + +L ++ +PGSP R K
Sbjct: 181 PPLCASPSDIELKALGLDSPLTEKEDDFFSLQAGHP-SSCNTSKAVNEPGSPTRKVSNLK 239
Query: 233 PALAPKGPKLPHAPPWVKSPPLLMHQNRVASLQEELQDITPEEELSYKTNGLALSKRF-I 291
A P+ +L P + +P +L R Q+E + + E+ + ++ KR +
Sbjct: 240 RARLPQLKRLQSEPWGLIAPSVLAASTR----QDETHGASTDNEVIKSISDISFPKRGPL 295
Query: 292 TRHQSIDVKDTAHLLRAFDQASSRKMSYDEINCQSYLSEGN------QQCIEVPVDQDPD 345
+R SID KD +Q +S + ++ +G + +PVDQ+
Sbjct: 296 SRTNSIDSKDPTLFHTVTEQVLKIPVSSAPASWKAAYEKGQAPHPRLARRGTLPVDQEKC 355
Query: 346 SNQTIFASTLRSIVQKRNLGANHYSSDSQLSAGLTPPTS---EDGKALIGKKKILSPSPS 402
S L+ + L + Y D Q G PP S E GK + +KK+ S S
Sbjct: 356 GMGPSGPSALKEPASLKWLENDLYDLDIQ--PGPDPPNSISLESGKGPLDRKKLNSSHLS 413
Query: 403 QLSESKELLENIP---PGPLSRRNHAVLEGRGSGAFPLDHSVTQTRQGFLPPLNVNSHPP 459
S+E L+ +P P RR +LE RGSG LD ++ TR GFLPPLNVN +PP
Sbjct: 414 LFHGSRESLDTVPSTSPSSARRRPPHLLERRGSGTLLLDR-ISHTRPGFLPPLNVNLNPP 472
Query: 460 ISDINVNNKICSLLSCGQKVLMPTVPIFPK--EFKSKKMLLRRQSLQTEQIKQLVNF 514
I DI ++K L+ G K ++P P PK + +SKK LLRR S+Q EQ+KQL +F
Sbjct: 473 IPDIRSSSKPSCSLASGLKSMVPVAPSSPKRVDLRSKKKLLRRHSMQIEQMKQLSDF 529
>gi|239750889 PREDICTED: ankyrin repeat domain 34C [Homo sapiens]
Length = 534
Score = 371 bits (952), Expect = e-102
Identities = 239/537 (44%), Positives = 318/537 (59%), Gaps = 31/537 (5%)
Query: 1 MDEGMEISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQS 60
MD+ E+ ++GNSL+KAV RLRLTRLLLEGGAYINESND+GET LM+AC TKHVD QS
Sbjct: 1 MDDDTELRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQS 60
Query: 61 VSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYS 120
+SK+KMVKYLL+N ADPNIQDKSGKTAL+HAC+ +AG EVVSLLL++GAD SL+D + S
Sbjct: 61 ISKSKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGAS 120
Query: 121 ALVYAINSEDTETLKVLLSACKAKGKEVIIITTAKSPCGKHTTKQYLNMPP-VDIDGCHS 179
ALVYAIN++D + LK LL ACKAKGKEVIIITT KS G TTKQYLN+PP ++ HS
Sbjct: 121 ALVYAINADDKDALKHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKVEDRHS 180
Query: 180 PATCTTPSEIDIKT--ASSPLSHSSETELTLFGFKDLELAGSNDDTWDPGSPVR-----K 232
P C +PS+I++K SPL+ + +L ++ +PGSP R K
Sbjct: 181 PPLCASPSDIELKALGLDSPLTEKEDDFFSLQAGHP-SSCNTSKAVNEPGSPTRKVSNLK 239
Query: 233 PALAPKGPKLPHAPPWVKSPPLLMHQNRVASLQEELQDITPEEELSYKTNGLALSKRF-I 291
A P+ +L P + +P +L R Q+E + + E+ + ++ KR +
Sbjct: 240 RARLPQLKRLQSEPWGLIAPSVLAASTR----QDETHGASTDNEVIKSISDISFPKRGPL 295
Query: 292 TRHQSIDVKDTAHLLRAFDQASSRKMSYDEINCQSYLSEGN------QQCIEVPVDQDPD 345
+R SID KD +Q +S + ++ +G + +PVDQ+
Sbjct: 296 SRTNSIDSKDPTLFHTVTEQVLKIPVSSAPASWKAAYEKGQAPHPRLARRGTLPVDQEKC 355
Query: 346 SNQTIFASTLRSIVQKRNLGANHYSSDSQLSAGLTPPTS---EDGKALIGKKKILSPSPS 402
S L+ + L + Y D Q G PP S E GK + +KK+ S S
Sbjct: 356 GMGPSGPSALKEPASLKWLENDLYDLDIQ--PGPDPPNSISLESGKGPLDRKKLNSSHLS 413
Query: 403 QLSESKELLENIP---PGPLSRRNHAVLEGRGSGAFPLDHSVTQTRQGFLPPLNVNSHPP 459
S+E L+ +P P RR +LE RGSG LD ++ TR GFLPPLNVN +PP
Sbjct: 414 LFHGSRESLDTVPSTSPSSARRRPPHLLERRGSGTLLLDR-ISHTRPGFLPPLNVNLNPP 472
Query: 460 ISDINVNNKICSLLSCGQKVLMPTVPIFPK--EFKSKKMLLRRQSLQTEQIKQLVNF 514
I DI ++K L+ G K ++P P PK + +SKK LLRR S+Q EQ+KQL +F
Sbjct: 473 IPDIRSSSKPSCSLASGLKSMVPVAPSSPKRVDLRSKKKLLRRHSMQIEQMKQLSDF 529
>gi|239745252 PREDICTED: ankyrin repeat domain 34C [Homo sapiens]
Length = 535
Score = 371 bits (952), Expect = e-102
Identities = 239/537 (44%), Positives = 318/537 (59%), Gaps = 31/537 (5%)
Query: 1 MDEGMEISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQS 60
MD+ E+ ++GNSL+KAV RLRLTRLLLEGGAYINESND+GET LM+AC TKHVD QS
Sbjct: 2 MDDDTELRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDQQS 61
Query: 61 VSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYS 120
+SK+KMVKYLL+N ADPNIQDKSGKTAL+HAC+ +AG EVVSLLL++GAD SL+D + S
Sbjct: 62 ISKSKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPSLEDRTGAS 121
Query: 121 ALVYAINSEDTETLKVLLSACKAKGKEVIIITTAKSPCGKHTTKQYLNMPP-VDIDGCHS 179
ALVYAIN++D + LK LL ACKAKGKEVIIITT KS G TTKQYLN+PP ++ HS
Sbjct: 122 ALVYAINADDKDALKHLLDACKAKGKEVIIITTDKSSSGTKTTKQYLNVPPSPKVEDRHS 181
Query: 180 PATCTTPSEIDIKT--ASSPLSHSSETELTLFGFKDLELAGSNDDTWDPGSPVR-----K 232
P C +PS+I++K SPL+ + +L ++ +PGSP R K
Sbjct: 182 PPLCASPSDIELKALGLDSPLTEKEDDFFSLQAGHP-SSCNTSKAVNEPGSPTRKVSNLK 240
Query: 233 PALAPKGPKLPHAPPWVKSPPLLMHQNRVASLQEELQDITPEEELSYKTNGLALSKRF-I 291
A P+ +L P + +P +L R Q+E + + E+ + ++ KR +
Sbjct: 241 RARLPQLKRLQSEPWGLIAPSVLAASTR----QDETHGASTDNEVIKSISDISFPKRGPL 296
Query: 292 TRHQSIDVKDTAHLLRAFDQASSRKMSYDEINCQSYLSEGN------QQCIEVPVDQDPD 345
+R SID KD +Q +S + ++ +G + +PVDQ+
Sbjct: 297 SRTNSIDSKDPTLFHTVTEQVLKIPVSSAPASWKAAYEKGQAPHPRLARRGTLPVDQEKC 356
Query: 346 SNQTIFASTLRSIVQKRNLGANHYSSDSQLSAGLTPPTS---EDGKALIGKKKILSPSPS 402
S L+ + L + Y D Q G PP S E GK + +KK+ S S
Sbjct: 357 GMGPSGPSALKEPASLKWLENDLYDLDIQ--PGPDPPNSISLESGKGPLDRKKLNSSHLS 414
Query: 403 QLSESKELLENIP---PGPLSRRNHAVLEGRGSGAFPLDHSVTQTRQGFLPPLNVNSHPP 459
S+E L+ +P P RR +LE RGSG LD ++ TR GFLPPLNVN +PP
Sbjct: 415 LFHGSRESLDTVPSTSPSSARRRPPHLLERRGSGTLLLDR-ISHTRPGFLPPLNVNLNPP 473
Query: 460 ISDINVNNKICSLLSCGQKVLMPTVPIFPK--EFKSKKMLLRRQSLQTEQIKQLVNF 514
I DI ++K L+ G K ++P P PK + +SKK LLRR S+Q EQ+KQL +F
Sbjct: 474 IPDIRSSSKPSCSLASGLKSMVPVAPSSPKRVDLRSKKKLLRRHSMQIEQMKQLSDF 530
>gi|89941470 ankyrin repeat domain 34 [Homo sapiens]
Length = 496
Score = 266 bits (680), Expect = 3e-71
Identities = 205/541 (37%), Positives = 273/541 (50%), Gaps = 90/541 (16%)
Query: 7 ISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKM 66
+ +EG++L++AV Q +LRL RLLLEGGAY+NE + +GET LM AC+ ++ D Q+ KA+M
Sbjct: 2 LHTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQN--KARM 59
Query: 67 VKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAI 126
V+YLLE ADPNI D+ G+TALMHAC G V SLLL GAD S++DH+ SALV+A+
Sbjct: 60 VRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHAL 119
Query: 127 NSEDTETLKVLLSACKAKGKEVIIITTAKSPCGKHTTKQYLNMPPV-----DIDGCHSPA 181
+ D ETL LL ACKAKG EVIIITT SP G T+QYLN PP SP
Sbjct: 120 DRGDRETLATLLDACKAKGTEVIIITTDTSPSGTKKTRQYLNSPPSPGVEDPAPASPSPG 179
Query: 182 TCTTPSEIDIKTAS-------SPLSHSSETELTLFGFKDLELAGSNDDTWDPGSPVRKPA 234
CT+PSEI ++TA SP + E + +F F L DD P P+ KP
Sbjct: 180 FCTSPSEIQLQTAGGGGRGMLSPRAQEEEEKRDVFEF---PLPKPPDDP-SPSEPLPKPP 235
Query: 235 LAPKGP-KLPHAPPW-VKSPPLLMHQNRVASLQEELQDITPE------EELSYKTNGLAL 286
P P K ++ PW + +PP Q + P E L+ + NGL L
Sbjct: 236 RHPPKPLKRLNSEPWGLVAPP---------------QPVPPTEGRPGIERLTAEFNGLTL 280
Query: 287 S--KRFITRHQSIDVKD---------TAHLLRAFDQASSRKMSYDEINCQSYLSEGNQQC 335
+ R RH + +D + L + A + S + LS
Sbjct: 281 TGRPRLSRRHSTEGPEDPPPWAEKVTSGGPLSRRNTAPEAQESGPPSGLRQKLSRMEPVE 340
Query: 336 IEVPVDQDPDSNQTIFASTLRSIVQKRNLGANHYSSDSQLSAGLTPPTSEDGKALIGKKK 395
++ P PDS ++ + +L YS+ S PP
Sbjct: 341 LDTPGHLCPDSPES----------SRLSLERRRYSA----SPLTLPPAGS---------- 376
Query: 396 ILSPSPSQLSESKELLENIPPGPLSRRNHAVLEGRGSGAFPLDHSVTQTRQGFLPPLNVN 455
+PSP Q ES L + P RR+ +LE RGSG LDH ++QTR GFLPPLNV+
Sbjct: 377 --APSPRQSQES--LPGAVSPLSGRRRSPGLLERRGSGTLLLDH-ISQTRPGFLPPLNVS 431
Query: 456 SHPPISDINVNNKICSLLSCGQKVLMPTVPI--FPKEFKSKKMLLRRQSLQTEQIKQLVN 513
HPPI DI G+ +P P P ++K+ L+RR S+QTEQI+ L
Sbjct: 432 PHPPIPDIRPQ-------PGGRAPSLPAPPYAGAPGSPRTKRKLVRRHSMQTEQIRLLGG 484
Query: 514 F 514
F
Sbjct: 485 F 485
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 68.6 bits (166), Expect = 1e-11
Identities = 48/132 (36%), Positives = 72/132 (54%), Gaps = 9/132 (6%)
Query: 8 SSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMV 67
SS +L A Q L+ ++L E + IN + G PL++A + H +++
Sbjct: 120 SSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH--------SEIC 171
Query: 68 KYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAIN 127
+LL++ AD N ++KSG+TALM AC E V L+K GADL+L D Y+AL Y+
Sbjct: 172 HFLLDHGADVNSRNKSGRTALMLAC-EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 230
Query: 128 SEDTETLKVLLS 139
SE+ +LLS
Sbjct: 231 SENAGIQSLLLS 242
Score = 38.9 bits (89), Expect = 0.011
Identities = 32/131 (24%), Positives = 59/131 (45%), Gaps = 10/131 (7%)
Query: 9 SEGNSLIK-AVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMV 67
SEG + A + + R+++ G + + G + L +A K H H+ + K
Sbjct: 54 SEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSH--HECIRK---- 107
Query: 68 KYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAIN 127
LL++ D SGKTAL +A + + V +L + + ++L+D L+ A+
Sbjct: 108 --LLQSKCPAESVDSSGKTALHYAAAQGC-LQAVQILCEHKSPINLKDLDGNIPLLLAVQ 164
Query: 128 SEDTETLKVLL 138
+ +E LL
Sbjct: 165 NGHSEICHFLL 175
Score = 37.4 bits (85), Expect = 0.033
Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 65 KMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVY 124
K+ L + A D GKTA H K E + +++ G D++ QD + +SAL
Sbjct: 37 KVASLLGKKGASATKHDSEGKTAF-HLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHL 95
Query: 125 AINSEDTETL-KVLLSACKAK 144
A + E + K+L S C A+
Sbjct: 96 AAKNSHHECIRKLLQSKCPAE 116
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 68.6 bits (166), Expect = 1e-11
Identities = 48/132 (36%), Positives = 72/132 (54%), Gaps = 9/132 (6%)
Query: 8 SSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMV 67
SS +L A Q L+ ++L E + IN + G PL++A + H +++
Sbjct: 109 SSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH--------SEIC 160
Query: 68 KYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAIN 127
+LL++ AD N ++KSG+TALM AC E V L+K GADL+L D Y+AL Y+
Sbjct: 161 HFLLDHGADVNSRNKSGRTALMLAC-EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 219
Query: 128 SEDTETLKVLLS 139
SE+ +LLS
Sbjct: 220 SENAGIQSLLLS 231
Score = 38.9 bits (89), Expect = 0.011
Identities = 32/131 (24%), Positives = 59/131 (45%), Gaps = 10/131 (7%)
Query: 9 SEGNSLIK-AVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMV 67
SEG + A + + R+++ G + + G + L +A K H H+ + K
Sbjct: 43 SEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSH--HECIRK---- 96
Query: 68 KYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAIN 127
LL++ D SGKTAL +A + + V +L + + ++L+D L+ A+
Sbjct: 97 --LLQSKCPAESVDSSGKTALHYAAAQGC-LQAVQILCEHKSPINLKDLDGNIPLLLAVQ 153
Query: 128 SEDTETLKVLL 138
+ +E LL
Sbjct: 154 NGHSEICHFLL 164
Score = 37.4 bits (85), Expect = 0.033
Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 65 KMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVY 124
K+ L + A D GKTA H K E + +++ G D++ QD + +SAL
Sbjct: 26 KVASLLGKKGASATKHDSEGKTAF-HLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHL 84
Query: 125 AINSEDTETL-KVLLSACKAK 144
A + E + K+L S C A+
Sbjct: 85 AAKNSHHECIRKLLQSKCPAE 105
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 68.6 bits (166), Expect = 1e-11
Identities = 48/132 (36%), Positives = 72/132 (54%), Gaps = 9/132 (6%)
Query: 8 SSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMV 67
SS +L A Q L+ ++L E + IN + G PL++A + H +++
Sbjct: 117 SSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH--------SEIC 168
Query: 68 KYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAIN 127
+LL++ AD N ++KSG+TALM AC E V L+K GADL+L D Y+AL Y+
Sbjct: 169 HFLLDHGADVNSRNKSGRTALMLAC-EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 227
Query: 128 SEDTETLKVLLS 139
SE+ +LLS
Sbjct: 228 SENAGIQSLLLS 239
Score = 38.9 bits (89), Expect = 0.011
Identities = 32/131 (24%), Positives = 59/131 (45%), Gaps = 10/131 (7%)
Query: 9 SEGNSLIK-AVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMV 67
SEG + A + + R+++ G + + G + L +A K H H+ + K
Sbjct: 51 SEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSH--HECIRK---- 104
Query: 68 KYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAIN 127
LL++ D SGKTAL +A + + V +L + + ++L+D L+ A+
Sbjct: 105 --LLQSKCPAESVDSSGKTALHYAAAQGC-LQAVQILCEHKSPINLKDLDGNIPLLLAVQ 161
Query: 128 SEDTETLKVLL 138
+ +E LL
Sbjct: 162 NGHSEICHFLL 172
Score = 37.4 bits (85), Expect = 0.033
Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 65 KMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVY 124
K+ L + A D GKTA H K E + +++ G D++ QD + +SAL
Sbjct: 34 KVASLLGKKGASATKHDSEGKTAF-HLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHL 92
Query: 125 AINSEDTETL-KVLLSACKAK 144
A + E + K+L S C A+
Sbjct: 93 AAKNSHHECIRKLLQSKCPAE 113
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 68.6 bits (166), Expect = 1e-11
Identities = 48/132 (36%), Positives = 72/132 (54%), Gaps = 9/132 (6%)
Query: 8 SSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMV 67
SS +L A Q L+ ++L E + IN + G PL++A + H +++
Sbjct: 117 SSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH--------SEIC 168
Query: 68 KYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAIN 127
+LL++ AD N ++KSG+TALM AC E V L+K GADL+L D Y+AL Y+
Sbjct: 169 HFLLDHGADVNSRNKSGRTALMLAC-EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 227
Query: 128 SEDTETLKVLLS 139
SE+ +LLS
Sbjct: 228 SENAGIQSLLLS 239
Score = 38.9 bits (89), Expect = 0.011
Identities = 32/131 (24%), Positives = 59/131 (45%), Gaps = 10/131 (7%)
Query: 9 SEGNSLIK-AVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMV 67
SEG + A + + R+++ G + + G + L +A K H H+ + K
Sbjct: 51 SEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSH--HECIRK---- 104
Query: 68 KYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAIN 127
LL++ D SGKTAL +A + + V +L + + ++L+D L+ A+
Sbjct: 105 --LLQSKCPAESVDSSGKTALHYAAAQGC-LQAVQILCEHKSPINLKDLDGNIPLLLAVQ 161
Query: 128 SEDTETLKVLL 138
+ +E LL
Sbjct: 162 NGHSEICHFLL 172
Score = 37.4 bits (85), Expect = 0.033
Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 65 KMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVY 124
K+ L + A D GKTA H K E + +++ G D++ QD + +SAL
Sbjct: 34 KVASLLGKKGASATKHDSEGKTAF-HLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHL 92
Query: 125 AINSEDTETL-KVLLSACKAK 144
A + E + K+L S C A+
Sbjct: 93 AAKNSHHECIRKLLQSKCPAE 113
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 68.6 bits (166), Expect = 1e-11
Identities = 48/132 (36%), Positives = 72/132 (54%), Gaps = 9/132 (6%)
Query: 8 SSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMV 67
SS +L A Q L+ ++L E + IN + G PL++A + H +++
Sbjct: 117 SSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH--------SEIC 168
Query: 68 KYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAIN 127
+LL++ AD N ++KSG+TALM AC E V L+K GADL+L D Y+AL Y+
Sbjct: 169 HFLLDHGADVNSRNKSGRTALMLAC-EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 227
Query: 128 SEDTETLKVLLS 139
SE+ +LLS
Sbjct: 228 SENAGIQSLLLS 239
Score = 38.9 bits (89), Expect = 0.011
Identities = 32/131 (24%), Positives = 59/131 (45%), Gaps = 10/131 (7%)
Query: 9 SEGNSLIK-AVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMV 67
SEG + A + + R+++ G + + G + L +A K H H+ + K
Sbjct: 51 SEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSH--HECIRK---- 104
Query: 68 KYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAIN 127
LL++ D SGKTAL +A + + V +L + + ++L+D L+ A+
Sbjct: 105 --LLQSKCPAESVDSSGKTALHYAAAQGC-LQAVQILCEHKSPINLKDLDGNIPLLLAVQ 161
Query: 128 SEDTETLKVLL 138
+ +E LL
Sbjct: 162 NGHSEICHFLL 172
Score = 37.4 bits (85), Expect = 0.033
Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 65 KMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVY 124
K+ L + A D GKTA H K E + +++ G D++ QD + +SAL
Sbjct: 34 KVASLLGKKGASATKHDSEGKTAF-HLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHL 92
Query: 125 AINSEDTETL-KVLLSACKAK 144
A + E + K+L S C A+
Sbjct: 93 AAKNSHHECIRKLLQSKCPAE 113
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 68.6 bits (166), Expect = 1e-11
Identities = 48/132 (36%), Positives = 72/132 (54%), Gaps = 9/132 (6%)
Query: 8 SSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMV 67
SS +L A Q L+ ++L E + IN + G PL++A + H +++
Sbjct: 117 SSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH--------SEIC 168
Query: 68 KYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAIN 127
+LL++ AD N ++KSG+TALM AC E V L+K GADL+L D Y+AL Y+
Sbjct: 169 HFLLDHGADVNSRNKSGRTALMLAC-EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 227
Query: 128 SEDTETLKVLLS 139
SE+ +LLS
Sbjct: 228 SENAGIQSLLLS 239
Score = 38.9 bits (89), Expect = 0.011
Identities = 32/131 (24%), Positives = 59/131 (45%), Gaps = 10/131 (7%)
Query: 9 SEGNSLIK-AVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMV 67
SEG + A + + R+++ G + + G + L +A K H H+ + K
Sbjct: 51 SEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSH--HECIRK---- 104
Query: 68 KYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAIN 127
LL++ D SGKTAL +A + + V +L + + ++L+D L+ A+
Sbjct: 105 --LLQSKCPAESVDSSGKTALHYAAAQGC-LQAVQILCEHKSPINLKDLDGNIPLLLAVQ 161
Query: 128 SEDTETLKVLL 138
+ +E LL
Sbjct: 162 NGHSEICHFLL 172
Score = 37.4 bits (85), Expect = 0.033
Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 65 KMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVY 124
K+ L + A D GKTA H K E + +++ G D++ QD + +SAL
Sbjct: 34 KVASLLGKKGASATKHDSEGKTAF-HLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHL 92
Query: 125 AINSEDTETL-KVLLSACKAK 144
A + E + K+L S C A+
Sbjct: 93 AAKNSHHECIRKLLQSKCPAE 113
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 64.7 bits (156), Expect = 2e-10
Identities = 40/143 (27%), Positives = 78/143 (54%), Gaps = 13/143 (9%)
Query: 1 MDEGMEISSEGNSLIKAVHQSRL----RLTRLLLEGGAYINESNDRGETPLMIACKTKHV 56
+ + +++ +E +AVH + + +L G A +N N R +TPL IA H+
Sbjct: 484 LKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHL 543
Query: 57 DHQSVSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDH 116
++VK LL+ P++QD G T L H + K +++++LL++GAD+++ ++
Sbjct: 544 --------QVVKTLLDFGCHPSLQDSEGDTPL-HDAISKKRDDILAVLLEAGADVTITNN 594
Query: 117 SSYSALVYAINSEDTETLKVLLS 139
+ ++AL +A + ++VLLS
Sbjct: 595 NGFNALHHAALRGNPSAMRVLLS 617
Score = 47.4 bits (111), Expect = 3e-05
Identities = 39/144 (27%), Positives = 73/144 (50%), Gaps = 15/144 (10%)
Query: 1 MDEGMEISSEGNSLIKAVHQSRLR----LTRLLLEGGA---YINESNDRGETPLMIACKT 53
++ G +++ N+ A+H + LR R+LL ++E D G T L +A
Sbjct: 583 LEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALN 642
Query: 54 KHVDHQSVSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSL 113
HV+ A+++ + + NA+ +IQ+ + +TAL H +E+ ++V LL+++GA L +
Sbjct: 643 NHVE-----VAELLVH--QGNANLDIQNVNQQTAL-HLAVERQHTQIVRLLVRAGAKLDI 694
Query: 114 QDHSSYSALVYAINSEDTETLKVL 137
QD + L A+ L+ L
Sbjct: 695 QDKDGDTPLHEALRHHTLSQLRQL 718
Score = 37.4 bits (85), Expect = 0.033
Identities = 35/132 (26%), Positives = 63/132 (47%), Gaps = 12/132 (9%)
Query: 11 GNSLIKAVHQS-RLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVS-KAKMVK 68
G++ ++A Q+ + + +LLL+ + + G+ + V H + + +++
Sbjct: 464 GHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGD---------RAVHHAAFGDEGAVIE 514
Query: 69 YLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINS 128
L +AD N ++K +T L H + K +VV LL G SLQD + L AI+
Sbjct: 515 VLHRGSADLNARNKRRQTPL-HIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISK 573
Query: 129 EDTETLKVLLSA 140
+ + L VLL A
Sbjct: 574 KRDDILAVLLEA 585
Score = 37.0 bits (84), Expect = 0.043
Identities = 27/118 (22%), Positives = 56/118 (47%), Gaps = 9/118 (7%)
Query: 9 SEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVK 68
++ +L AV + ++ RLL+ GA ++ + G+TPL A + H ++S+ + ++
Sbjct: 665 NQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALR-----HHTLSQLRQLQ 719
Query: 69 YLLENNADPNIQDKSGKTALM----HACLEKAGPEVVSLLLKSGADLSLQDHSSYSAL 122
+ + + S T +M +K+ + L +GADLS+++ S L
Sbjct: 720 DMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPL 777
>gi|17864094 feminization 1 homolog a [Homo sapiens]
Length = 617
Score = 62.0 bits (149), Expect = 1e-09
Identities = 39/125 (31%), Positives = 63/125 (50%), Gaps = 9/125 (7%)
Query: 23 LRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLENNADPNIQDK 82
L++ + LL GA +N + TPL AC H++ +VKYL+E+ AD + ++
Sbjct: 96 LKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLE--------IVKYLVEHKADLEVSNR 147
Query: 83 SGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLLSACK 142
G T LM +C K E+ LL+ GAD++ + +AL S + +K+LL C
Sbjct: 148 HGHTCLMISCY-KGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCA 206
Query: 143 AKGKE 147
K+
Sbjct: 207 KMEKD 211
Score = 47.0 bits (110), Expect = 4e-05
Identities = 30/89 (33%), Positives = 43/89 (48%), Gaps = 9/89 (10%)
Query: 17 AVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLENNAD 76
A L + + L+E A + SN G T LMI+C H ++ +YLLE AD
Sbjct: 123 ACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGH--------KEIAQYLLEKGAD 174
Query: 77 PNIQDKSGKTALMHACLEKAGPEVVSLLL 105
N + G TAL H C E +++ +LL
Sbjct: 175 VNRKSVKGNTAL-HDCAESGSLDIMKMLL 202
Score = 34.7 bits (78), Expect = 0.21
Identities = 37/173 (21%), Positives = 64/173 (36%), Gaps = 18/173 (10%)
Query: 6 EISSEGNSLIKAVHQSRLRLTRLLLE---------GGAYINESNDRGETPLMIACKTKHV 56
E ++ L+ A L + LLE G + G PL A H+
Sbjct: 37 EKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHL 96
Query: 57 DHQSVSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDH 116
K+V+ LL + A N + T L AC + E+V L++ ADL + +
Sbjct: 97 --------KVVQSLLNHGASVNNTTLTNSTPLRAACFD-GHLEIVKYLVEHKADLEVSNR 147
Query: 117 SSYSALVYAINSEDTETLKVLLSACKAKGKEVIIITTAKSPCGKHTTKQYLNM 169
++ L+ + E + LL ++ + TA C + + + M
Sbjct: 148 HGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKM 200
Score = 30.4 bits (67), Expect = 4.0
Identities = 16/40 (40%), Positives = 25/40 (62%), Gaps = 1/40 (2%)
Query: 70 LLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGA 109
L+E AD N++D + L A L P++++LL+KSGA
Sbjct: 514 LIECGADVNVRDSDDNSPLHIAALNNH-PDIMNLLIKSGA 552
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 62.0 bits (149), Expect = 1e-09
Identities = 39/103 (37%), Positives = 57/103 (55%), Gaps = 9/103 (8%)
Query: 28 LLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLENNADPNIQDKSGKTA 87
LL + A+++ ++ G TPLMIA H A + LL+ A N+ DK+ K+A
Sbjct: 138 LLCDHEAFLDVLDNDGRTPLMIASLGGH--------AAICSQLLQRGARVNVTDKNDKSA 189
Query: 88 LMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSED 130
L+ AC EK EV LLL GAD D + + AL YA++++D
Sbjct: 190 LILAC-EKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQD 231
Score = 41.2 bits (95), Expect = 0.002
Identities = 40/137 (29%), Positives = 60/137 (43%), Gaps = 26/137 (18%)
Query: 28 LLLEGGAYINESNDRGETPLMIA---CKTKHVD--------------------HQSVSK- 63
+LL GA IN N+ G T L +A C+ + V H + S
Sbjct: 72 ILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSG 131
Query: 64 -AKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSAL 122
A V L ++ A ++ D G+T LM A L + S LL+ GA +++ D + SAL
Sbjct: 132 CASSVLLLCDHEAFLDVLDNDGRTPLMIASLG-GHAAICSQLLQRGARVNVTDKNDKSAL 190
Query: 123 VYAINSEDTETLKVLLS 139
+ A E ++LLS
Sbjct: 191 ILACEKGSAEVAELLLS 207
Score = 31.2 bits (69), Expect = 2.4
Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 1/65 (1%)
Query: 74 NADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTET 133
+A P D +G++ H K E +++LL +GAD++ ++ +AL A S +
Sbjct: 44 SARPTKLDSNGQSPF-HLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQC 102
Query: 134 LKVLL 138
+KVLL
Sbjct: 103 VKVLL 107
>gi|67906195 ankyrin repeat and sterile alpha motif domain
containing 6 [Homo sapiens]
Length = 871
Score = 61.6 bits (148), Expect = 2e-09
Identities = 43/120 (35%), Positives = 64/120 (53%), Gaps = 12/120 (10%)
Query: 31 EGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLENNADPNIQDK-SGKTALM 89
E +++N N G TPLM+A T + +V+ L+E +AD + QD G TALM
Sbjct: 314 EDPSHVNLVNGDGATPLMLAAVT--------GQLALVQLLVERHADVDKQDSVHGWTALM 365
Query: 90 HACLEKAGPEVVSLLLKSGADLSLQDHSSYSA--LVYAINSEDTETLKVLLSACKAKGKE 147
A E+V LL GAD++L+ + Y+A LV +N DTE +++L S C K+
Sbjct: 366 QATYH-GNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKD 424
Score = 37.7 bits (86), Expect = 0.025
Identities = 31/102 (30%), Positives = 44/102 (43%), Gaps = 9/102 (8%)
Query: 39 SNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGP 98
S++ G T L A H +V++LL A N ++ G +ALM A
Sbjct: 74 SDEAGNTALQFAAAGGH--------EPLVRFLLRRGASVNSRNHYGWSALMQAA-RFGHV 124
Query: 99 EVVSLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLLSA 140
V LLL GAD++ Q+ S L A +K+LL A
Sbjct: 125 SVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEA 166
Score = 34.7 bits (78), Expect = 0.21
Identities = 33/139 (23%), Positives = 62/139 (44%), Gaps = 29/139 (20%)
Query: 1 MDEGMEISSEG----NSLIKAVHQSRLRLTRLLLEGGAYINESNDRGE---------TPL 47
+D G +++++ + L A L + +LLLE GA+++ + GE PL
Sbjct: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
Query: 48 MIACKTKHVDHQSVSKAKMVKYLLENNADPN------------IQDKSGKTALMHACLEK 95
I + H +V+ L+E ADPN + +G+ + +EK
Sbjct: 191 DITALMAAIQH---GHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEK 247
Query: 96 -AGPEVVSLLLKSGADLSL 113
A P+ +S+L K+ +++L
Sbjct: 248 GANPDHLSVLEKTAFEVAL 266
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 61.6 bits (148), Expect = 2e-09
Identities = 41/127 (32%), Positives = 71/127 (55%), Gaps = 9/127 (7%)
Query: 13 SLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLE 72
S+I V + + + LLE ++E N+ G+TPLMIA + +++ +VK L++
Sbjct: 8 SVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLE--------IVKELIK 59
Query: 73 NNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTE 132
N A+ N++D TAL+ A E +V LLK G +L +D ++AL++A T+
Sbjct: 60 NGANCNLEDLDNWTALISASKE-GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTD 118
Query: 133 TLKVLLS 139
+++LLS
Sbjct: 119 VVELLLS 125
Score = 55.1 bits (131), Expect = 2e-07
Identities = 43/150 (28%), Positives = 68/150 (45%), Gaps = 26/150 (17%)
Query: 14 LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKH-------------VDHQS 60
+I A + + LLL+ GA +N S+ G TPL+ A + H VD +
Sbjct: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200
Query: 61 VSK------------AKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSG 108
+ + VK +L+ N + N+ DK G TALM A E E+V LL +G
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKE-GHTEIVQDLLDAG 259
Query: 109 ADLSLQDHSSYSALVYAINSEDTETLKVLL 138
+++ D S + L+ A+ E ++ LL
Sbjct: 260 TYVNIPDRSGDTVLIGAVRGGHVEIVRALL 289
Score = 49.3 bits (116), Expect = 8e-06
Identities = 42/160 (26%), Positives = 74/160 (46%), Gaps = 19/160 (11%)
Query: 4 GMEISSEG----NSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQ 59
G ++ EG +LI AV + + +L+ +N ++ G T LMIA K H +
Sbjct: 193 GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTE-- 250
Query: 60 SVSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSY 119
+V+ LL+ NI D+SG T L+ A + E+V LL+ AD+ ++ +
Sbjct: 251 ------IVQDLLDAGTYVNIPDRSGDTVLIGA-VRGGHVEIVRALLQKYADIDIRGQDNK 303
Query: 120 SALVYAINSEDTETLKVLLSA------CKAKGKEVIIITT 153
+AL +A+ + ++ +L C G+ +I T
Sbjct: 304 TALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKAT 343
Score = 47.0 bits (110), Expect = 4e-05
Identities = 36/130 (27%), Positives = 66/130 (50%), Gaps = 10/130 (7%)
Query: 10 EGNS-LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVK 68
+GN+ L+ A + + + LL+ G Y+N + G+T L+ A + HV+ +V+
Sbjct: 235 DGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVE--------IVR 286
Query: 69 YLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINS 128
LL+ AD +I+ + KTAL A +EK +V +L+ D + + L+ A
Sbjct: 287 ALLQKYADIDIRGQDNKTALYWA-VEKGNATMVRDILQCNPDTEICTKDGETPLIKATKM 345
Query: 129 EDTETLKVLL 138
+ E +++LL
Sbjct: 346 RNIEVVELLL 355
Score = 40.8 bits (94), Expect = 0.003
Identities = 33/127 (25%), Positives = 59/127 (46%), Gaps = 9/127 (7%)
Query: 13 SLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLE 72
+LI A + + + LL+ G + + G T LM AC D +V+ LL
Sbjct: 74 ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTD--------VVELLLS 125
Query: 73 NNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTE 132
+ A+P++ ++ A + ++V LLL++GA ++ D + LV+A E
Sbjct: 126 HGANPSVTGLYSVYPIIWAA-GRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLE 184
Query: 133 TLKVLLS 139
+K LL+
Sbjct: 185 CVKHLLA 191
Score = 35.4 bits (80), Expect = 0.13
Identities = 23/76 (30%), Positives = 39/76 (51%), Gaps = 11/76 (14%)
Query: 14 LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLEN 73
LIKA + + LLL+ GA ++ + +G+TPL IA + + K+ + LL N
Sbjct: 339 LIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGR--------SRKLAELLLRN 390
Query: 74 NADPNI---QDKSGKT 86
D + +K+G+T
Sbjct: 391 PKDGRLLYRPNKAGET 406
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 61.2 bits (147), Expect = 2e-09
Identities = 40/124 (32%), Positives = 70/124 (56%), Gaps = 11/124 (8%)
Query: 27 RLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLENNADPNIQDKSGKT 86
+LL + GA +N + G TPL++A + +S+ + + L++ AD N +DK +T
Sbjct: 138 QLLCDHGASVNAKDVDGRTPLVLATQ--------MSRPTICQLLIDRGADVNSRDKQNRT 189
Query: 87 ALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLLSACK--AK 144
ALM C E + V +L+K+GAD+SL D + + YA ++ + L +L +A + K
Sbjct: 190 ALMLGC-EYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNK 248
Query: 145 GKEV 148
G+E+
Sbjct: 249 GREL 252
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 61.2 bits (147), Expect = 2e-09
Identities = 40/124 (32%), Positives = 70/124 (56%), Gaps = 11/124 (8%)
Query: 27 RLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLENNADPNIQDKSGKT 86
+LL + GA +N + G TPL++A + +S+ + + L++ AD N +DK +T
Sbjct: 151 QLLCDHGASVNAKDVDGRTPLVLATQ--------MSRPTICQLLIDRGADVNSRDKQNRT 202
Query: 87 ALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLLSACK--AK 144
ALM C E + V +L+K+GAD+SL D + + YA ++ + L +L +A + K
Sbjct: 203 ALMLGC-EYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNK 261
Query: 145 GKEV 148
G+E+
Sbjct: 262 GREL 265
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 60.8 bits (146), Expect = 3e-09
Identities = 45/138 (32%), Positives = 74/138 (53%), Gaps = 13/138 (9%)
Query: 4 GMEISSEGNSL---IKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQS 60
G+ ++S+ S + A+H R L LLL+ GA N PL +AC+ H
Sbjct: 736 GVNVTSQDGSSPLHVAALH-GRADLIPLLLKHGANAGARNADQAVPLHLACQQGHF---- 790
Query: 61 VSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYS 120
++VK LL++NA PN +D SG T L++AC E+V+LLL+ GA ++ ++ +
Sbjct: 791 ----QVVKCLLDSNAKPNKKDLSGNTPLIYAC-SGGHHELVALLLQHGASINASNNKGNT 845
Query: 121 ALVYAINSEDTETLKVLL 138
AL A+ + +++LL
Sbjct: 846 ALHEAVIEKHVFVVELLL 863
Score = 48.1 bits (113), Expect = 2e-05
Identities = 40/124 (32%), Positives = 61/124 (49%), Gaps = 10/124 (8%)
Query: 17 AVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLENNAD 76
A Q ++ + LL+ A N+ + G TPL+ AC H + +V LL++ A
Sbjct: 784 ACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHE--------LVALLLQHGAS 835
Query: 77 PNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYA-INSEDTETLK 135
N + G TAL A +EK VV LLL GA + + + +A+ A NS+ E L+
Sbjct: 836 INASNNKGNTALHEAVIEK-HVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQ 894
Query: 136 VLLS 139
V+ S
Sbjct: 895 VVPS 898
Score = 37.7 bits (86), Expect = 0.025
Identities = 25/68 (36%), Positives = 35/68 (51%), Gaps = 8/68 (11%)
Query: 25 LTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLENNADPNIQDKSG 84
L LL+ GA +N ++ G TPL +AC+ +QSV+ LL A +QD +G
Sbjct: 478 LIDLLVSKGAMVNATDYHGATPLHLACQK---GYQSVT-----LLLLHYKASAEVQDNNG 529
Query: 85 KTALMHAC 92
T L AC
Sbjct: 530 NTPLHLAC 537
Score = 36.6 bits (83), Expect = 0.056
Identities = 30/105 (28%), Positives = 47/105 (44%), Gaps = 6/105 (5%)
Query: 25 LTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLENNADPNIQDKSG 84
+T LLL A ++ G TPL +AC H D K + Y + +I ++ G
Sbjct: 511 VTLLLLHYKASAEVQDNNGNTPLHLACTYGHED-----CVKALVYYDVESCRLDIGNEKG 565
Query: 85 KTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSE 129
T L H V+ LL++GA +Q+ + L A+NS+
Sbjct: 566 DTPL-HIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSK 609
Score = 35.8 bits (81), Expect = 0.096
Identities = 29/99 (29%), Positives = 43/99 (43%), Gaps = 9/99 (9%)
Query: 40 NDRGETPLMIACKTKHVDHQSVSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPE 99
+DRG TPL +A +A ++ L+ A N D G T L AC +K
Sbjct: 460 DDRGHTPLHVAAVC--------GQASLIDLLVSKGAMVNATDYHGATPLHLAC-QKGYQS 510
Query: 100 VVSLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLL 138
V LLL A +QD++ + L A + +K L+
Sbjct: 511 VTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALV 549
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 59.3 bits (142), Expect = 8e-09
Identities = 43/155 (27%), Positives = 78/155 (50%), Gaps = 14/155 (9%)
Query: 5 MEISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKA 64
ME ++ + L A + + +L++ GA I+ ++ TPLM A + H++
Sbjct: 768 MEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLE------- 820
Query: 65 KMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGA-DLSLQDHSSYSALV 123
VKYL++ A + +D G T L H +K EVV LL +G D++ QD ++ ++
Sbjct: 821 -AVKYLIKAGALVDPKDAEGSTCL-HLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMI 878
Query: 124 YAINSEDTETLKVLLSACKAKGKEVIIITTAKSPC 158
+A + + +K+LLS KG ++ I ++ C
Sbjct: 879 WATEYKHVDLVKLLLS----KGSDINIRDNEENIC 909
Score = 55.1 bits (131), Expect = 2e-07
Identities = 38/128 (29%), Positives = 66/128 (51%), Gaps = 10/128 (7%)
Query: 14 LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLEN 73
L++A + L + L++ GA ++ + G T L +A K H + +V+YLL N
Sbjct: 810 LMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYE--------VVQYLLSN 861
Query: 74 NA-DPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTE 132
D N QD G T ++ A E ++V LLL G+D++++D+ L +A S +
Sbjct: 862 GQMDVNCQDDGGWTPMIWAT-EYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVD 920
Query: 133 TLKVLLSA 140
++LL+A
Sbjct: 921 IAEILLAA 928
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 59.3 bits (142), Expect = 8e-09
Identities = 45/135 (33%), Positives = 63/135 (46%), Gaps = 9/135 (6%)
Query: 8 SSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMV 67
SS +L A L + +L A++N + G TPL+IA + H D +
Sbjct: 146 SSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTD--------LC 197
Query: 68 KYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAIN 127
+ LL+ A N QD G+TALM AC E A PE V +LL+ GA + D A Y
Sbjct: 198 RLLLQQGAAANDQDLQGRTALMLAC-EGASPETVEVLLQGGAQPGITDALGQDAAHYGAL 256
Query: 128 SEDTETLKVLLSACK 142
+ D L +L A +
Sbjct: 257 AGDKLILHLLQEAAQ 271
Score = 33.1 bits (74), Expect = 0.62
Identities = 36/141 (25%), Positives = 62/141 (43%), Gaps = 24/141 (17%)
Query: 6 EISSEGNSLIKAVHQSRLR----LTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSV 61
++ EG S A H + +R +++ G+ + ++ G L +A K H
Sbjct: 77 KLDPEGKS---AFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALHLAAKYGH------ 127
Query: 62 SKAKMVKYLLENNADPNIQDKSGKTALMHA----CLEKAGPEVVSLLLKSGADLSLQDHS 117
+ +K LL+ + ++ D SG TAL HA CL + +L A L+ QD S
Sbjct: 128 --PQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCS-----EVLCSFKAHLNPQDRS 180
Query: 118 SYSALVYAINSEDTETLKVLL 138
+ L+ A T+ ++LL
Sbjct: 181 GATPLIIAAQMCHTDLCRLLL 201
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 58.5 bits (140), Expect = 1e-08
Identities = 41/113 (36%), Positives = 55/113 (48%), Gaps = 9/113 (7%)
Query: 13 SLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLE 72
+L A + +L + LLL GA ++ +N RG PL A + H ++V+ LLE
Sbjct: 1074 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGH--------WQIVRLLLE 1125
Query: 73 NNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYA 125
D N+ DK G+T LM A E V LL GA LS D SAL +A
Sbjct: 1126 RGCDVNLSDKQGRTPLMVAACE-GHLSTVEFLLSKGAALSSLDKEGLSALSWA 1177
Score = 58.2 bits (139), Expect = 2e-08
Identities = 43/125 (34%), Positives = 61/125 (48%), Gaps = 9/125 (7%)
Query: 14 LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLEN 73
L A Q ++ RLLLE G +N S+ +G TPLM+A H+ V++LL
Sbjct: 1108 LFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHL--------STVEFLLSK 1159
Query: 74 NADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTET 133
A + DK G +AL ACL K VV L++ GA + D + + L A D ET
Sbjct: 1160 GAALSSLDKEGLSALSWACL-KGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAET 1218
Query: 134 LKVLL 138
+ L+
Sbjct: 1219 VLYLV 1223
Score = 39.7 bits (91), Expect = 0.007
Identities = 38/137 (27%), Positives = 66/137 (48%), Gaps = 13/137 (9%)
Query: 8 SSEGNSL----IKAVHQSRLRLTRLLLEGGAYINESND-RGETPLMIACKTKHVDHQSVS 62
S+EG S ++ ++ ++++RLL+ GGA +N + P++ C H+ H+ V
Sbjct: 886 STEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPIL--CVQSHLGHEEV- 942
Query: 63 KAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSAL 122
V LLE A + ++G TAL +A ++V LL K G + D AL
Sbjct: 943 ----VTLLLEFGACLDGTSENGMTALCYAA-AAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
Query: 123 VYAINSEDTETLKVLLS 139
V++ + L+ LL+
Sbjct: 998 VHSALRGHGDILQYLLT 1014
Score = 34.3 bits (77), Expect = 0.28
Identities = 27/99 (27%), Positives = 43/99 (43%), Gaps = 8/99 (8%)
Query: 6 EISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAK 65
E+ + L H + LLLE GA ++ +++ G T L A H+ K
Sbjct: 923 EVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHM--------K 974
Query: 66 MVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLL 104
+V L + + DK G+ AL+H+ L G + LL
Sbjct: 975 LVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLL 1013
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 58.5 bits (140), Expect = 1e-08
Identities = 41/113 (36%), Positives = 55/113 (48%), Gaps = 9/113 (7%)
Query: 13 SLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLE 72
+L A + +L + LLL GA ++ +N RG PL A + H ++V+ LLE
Sbjct: 1082 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGH--------WQIVRLLLE 1133
Query: 73 NNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYA 125
D N+ DK G+T LM A E V LL GA LS D SAL +A
Sbjct: 1134 RGCDVNLSDKQGRTPLMVAACE-GHLSTVEFLLSKGAALSSLDKEGLSALSWA 1185
Score = 58.2 bits (139), Expect = 2e-08
Identities = 43/125 (34%), Positives = 61/125 (48%), Gaps = 9/125 (7%)
Query: 14 LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLEN 73
L A Q ++ RLLLE G +N S+ +G TPLM+A H+ V++LL
Sbjct: 1116 LFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHL--------STVEFLLSK 1167
Query: 74 NADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTET 133
A + DK G +AL ACL K VV L++ GA + D + + L A D ET
Sbjct: 1168 GAALSSLDKEGLSALSWACL-KGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAET 1226
Query: 134 LKVLL 138
+ L+
Sbjct: 1227 VLYLV 1231
Score = 39.7 bits (91), Expect = 0.007
Identities = 38/137 (27%), Positives = 66/137 (48%), Gaps = 13/137 (9%)
Query: 8 SSEGNSL----IKAVHQSRLRLTRLLLEGGAYINESND-RGETPLMIACKTKHVDHQSVS 62
S+EG S ++ ++ ++++RLL+ GGA +N + P++ C H+ H+ V
Sbjct: 894 STEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPIL--CVQSHLGHEEV- 950
Query: 63 KAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSAL 122
V LLE A + ++G TAL +A ++V LL K G + D AL
Sbjct: 951 ----VTLLLEFGACLDGTSENGMTALCYAA-AAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
Query: 123 VYAINSEDTETLKVLLS 139
V++ + L+ LL+
Sbjct: 1006 VHSALRGHGDILQYLLT 1022
Score = 34.3 bits (77), Expect = 0.28
Identities = 27/99 (27%), Positives = 43/99 (43%), Gaps = 8/99 (8%)
Query: 6 EISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAK 65
E+ + L H + LLLE GA ++ +++ G T L A H+ K
Sbjct: 931 EVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHM--------K 982
Query: 66 MVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLL 104
+V L + + DK G+ AL+H+ L G + LL
Sbjct: 983 LVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLL 1021
>gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain
containing 1 [Homo sapiens]
Length = 475
Score = 58.2 bits (139), Expect = 2e-08
Identities = 39/129 (30%), Positives = 69/129 (53%), Gaps = 9/129 (6%)
Query: 1 MDEGMEISSE----GNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHV 56
+D G+ + S L+ A + L R+LL+ GA N S ++ + ++I + H
Sbjct: 66 LDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA--NASFEKDKQSILITACSAHG 123
Query: 57 DHQSVSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDH 116
+ + K V+ LL NADPN+ + T +M+A + +VV+LL+ GA+++ QD
Sbjct: 124 SEEQILKC--VELLLSRNADPNVACRRLMTPIMYAARD-GHTQVVALLVAHGAEVNTQDE 180
Query: 117 SSYSALVYA 125
+ Y+AL +A
Sbjct: 181 NGYTALTWA 189
Score = 37.0 bits (84), Expect = 0.043
Identities = 30/92 (32%), Positives = 45/92 (48%), Gaps = 9/92 (9%)
Query: 23 LRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLENNADPNIQDK 82
L+ LLL A N + R TP+M A + H ++V L+ + A+ N QD+
Sbjct: 129 LKCVELLLSRNADPNVACRRLMTPIMYAARDGHT--------QVVALLVAHGAEVNTQDE 180
Query: 83 SGKTALMHACLEKAGPEVVSLLLKSGADLSLQ 114
+G TAL A + +V LL+ GA+ LQ
Sbjct: 181 NGYTALTWAA-RQGHKNIVLKLLELGANKMLQ 211
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 58.2 bits (139), Expect = 2e-08
Identities = 46/158 (29%), Positives = 73/158 (46%), Gaps = 31/158 (19%)
Query: 9 SEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKA---- 64
S+ SL +A + + R LL G +NE + GE+ L +AC + + V A
Sbjct: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 292
Query: 65 ----------------------KMVKYLLENNADPNIQDKSGKTALMHACLEKAG--PEV 100
K+VK LL + AD N Q +G TAL +AC AG +V
Sbjct: 293 VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYAC---AGGYVDV 349
Query: 101 VSLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLL 138
V +LL+SGA + + + ++ L+ A ++ E ++LL
Sbjct: 350 VKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLL 387
Score = 57.0 bits (136), Expect = 4e-08
Identities = 42/134 (31%), Positives = 64/134 (47%), Gaps = 9/134 (6%)
Query: 8 SSEGNS-LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKM 66
SS GN+ L A + + ++LLE GA I + N+ G TPLM A HV+ +
Sbjct: 331 SSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVE--------V 382
Query: 67 VKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAI 126
+ LLEN A N K + + K E+V LL++GAD + ++AL+ A
Sbjct: 383 ARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEAC 442
Query: 127 NSEDTETLKVLLSA 140
E ++LL +
Sbjct: 443 MDGHVEVARLLLDS 456
Score = 55.1 bits (131), Expect = 2e-07
Identities = 41/133 (30%), Positives = 61/133 (45%), Gaps = 8/133 (6%)
Query: 8 SSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMV 67
S+ +L A L + LLE GA I + +G TPL++A HV +V
Sbjct: 1081 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVG--------VV 1132
Query: 68 KYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAIN 127
+ LL+N AD Q + K + EVV LLL GA+ ++ S Y+ L A +
Sbjct: 1133 EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 1192
Query: 128 SEDTETLKVLLSA 140
+K+LL+A
Sbjct: 1193 GGYVNIIKILLNA 1205
Score = 54.7 bits (130), Expect = 2e-07
Identities = 48/145 (33%), Positives = 70/145 (48%), Gaps = 17/145 (11%)
Query: 1 MDEGMEISSEGNS----LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHV 56
+D G +++ +S L A + L LL+E GA + E ND G TPLM A + H
Sbjct: 454 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGH- 512
Query: 57 DHQSVSKAKMVKYLLENNADPNIQ-DKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQD 115
+MV LL A+ N Q +++ +TAL AC EV L+K+GAD+ L
Sbjct: 513 -------EEMVALLLGQGANINAQTEETQETALTLACC-GGFLEVADFLIKAGADIEL-- 562
Query: 116 HSSYSALVYAINSEDTETLKVLLSA 140
+ L+ A E +K LL+A
Sbjct: 563 -GCSTPLMEAAQEGHLELVKYLLAA 586
Score = 51.2 bits (121), Expect = 2e-06
Identities = 43/158 (27%), Positives = 73/158 (46%), Gaps = 25/158 (15%)
Query: 6 EISSEGNS-LIKAVHQSRLRLTRLLLEGGAYIN-ESNDRGETPLMIAC------------ 51
E++ EG + L++A + + LLL GA IN ++ + ET L +AC
Sbjct: 495 EVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLI 554
Query: 52 ----------KTKHVDHQSVSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVV 101
T ++ ++VKYLL A+ + +G TAL +AC E +V
Sbjct: 555 KAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYAC-ENGHTDVA 613
Query: 102 SLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLLS 139
+LL++GADL + + L+ A + T++ L+S
Sbjct: 614 DVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLIS 651
Score = 50.1 bits (118), Expect = 5e-06
Identities = 44/140 (31%), Positives = 66/140 (47%), Gaps = 12/140 (8%)
Query: 3 EGMEISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVS 62
E I + L+ A + +++ +LLL A +N + G T L AC +VD
Sbjct: 294 EDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVD----- 348
Query: 63 KAKMVKYLLENNADPNIQDKSGKTALMHACLEKAG-PEVVSLLLKSGADLSLQDHS-SYS 120
+VK LLE+ A +++G T LM A AG EV LLL++GA ++ + S
Sbjct: 349 ---VVKVLLESGASIEDHNENGHTPLMEA--GSAGHVEVARLLLENGAGINTHSNEFKES 403
Query: 121 ALVYAINSEDTETLKVLLSA 140
AL A E ++ LL A
Sbjct: 404 ALTLACYKGHLEMVRFLLEA 423
Score = 47.8 bits (112), Expect = 2e-05
Identities = 39/129 (30%), Positives = 61/129 (47%), Gaps = 10/129 (7%)
Query: 13 SLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLE 72
+L++A + + RLLL+ GA +N D E+PL +A HV+ + L+E
Sbjct: 437 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE--------LAALLIE 488
Query: 73 NNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQ-DHSSYSALVYAINSEDT 131
A + G T LM A E E+V+LLL GA+++ Q + + +AL A
Sbjct: 489 RGASLEEVNDEGYTPLMEAARE-GHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
Query: 132 ETLKVLLSA 140
E L+ A
Sbjct: 548 EVADFLIKA 556
Score = 47.0 bits (110), Expect = 4e-05
Identities = 51/197 (25%), Positives = 84/197 (42%), Gaps = 36/197 (18%)
Query: 14 LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLEN 73
L++A + L L + LL GA ++ + G+T L AC+ H D V LL+
Sbjct: 568 LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADV--------LLQA 619
Query: 74 NADPNIQDKSGKTALMHACLEKAGPE-VVSLLLKSGADLS-LQDHSSYSALVYAINSEDT 131
AD + + G+T LM A +AG V L+ GA+++ ++ ++ L A
Sbjct: 620 GADLEHESEGGRTPLMKAA--RAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 677
Query: 132 ETLKVLLS-----ACKAKGKEVIIITTAKSPCGKHTT---------KQYLNMPPVDIDGC 177
+++LL+ + K ++I AK G HT+ L+ PP D+
Sbjct: 678 AVVELLLAHGADPTHRLKDGSTMLIEAAK---GGHTSVVCYLLDYPNNLLSAPPPDV--- 731
Query: 178 HSPATCTTPSEIDIKTA 194
T TP D+ A
Sbjct: 732 ----TQLTPPSHDLNRA 744
Score = 43.5 bits (101), Expect = 5e-04
Identities = 40/141 (28%), Positives = 61/141 (43%), Gaps = 19/141 (13%)
Query: 1 MDEGMEI------SSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTK 54
+D+G ++ SS +L A + + LL+ GA+I+ N +G TPL +A
Sbjct: 1305 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGG 1364
Query: 55 HVDHQSVSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQ 114
H+D +V+ L++ AD + D T LM A K +VV L+K Q
Sbjct: 1365 HLD--------VVQLLVQAGADVDAADNRKITPLM-AAFRKGHVKVVRYLVKE----VNQ 1411
Query: 115 DHSSYSALVYAINSEDTETLK 135
S + Y D E LK
Sbjct: 1412 FPSDSECMRYIATITDKEMLK 1432
Score = 43.1 bits (100), Expect = 6e-04
Identities = 44/143 (30%), Positives = 67/143 (46%), Gaps = 16/143 (11%)
Query: 9 SEGNSLIKAVHQSRLRLTRLLLEGGAYINE--SNDRGETPLMIACKTKHVDHQSVSKAKM 66
S+ L A + + ++LL GA IN + G +PLM+A H
Sbjct: 1182 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHT--------AA 1233
Query: 67 VKYLLENNADPNIQDKSGK-TALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYA 125
VK LL+ +D N Q ++ + TAL AC + EVVSLLL A++ + + + L+ A
Sbjct: 1234 VKLLLDMGSDINAQIETNRNTALTLACFQ-GRTEVVSLLLDRKANVEHRAKTGLTPLMEA 1292
Query: 126 INSEDTETLKVLLSACKAKGKEV 148
+ E +VLL KG +V
Sbjct: 1293 ASGGYAEVGRVLLD----KGADV 1311
Score = 37.4 bits (85), Expect = 0.033
Identities = 35/146 (23%), Positives = 63/146 (43%), Gaps = 14/146 (9%)
Query: 1 MDEGMEISSE-----GNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKH 55
+D G +I+++ +L A Q R + LLL+ A + G TPLM A
Sbjct: 1238 LDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAA---- 1293
Query: 56 VDHQSVSKAKMVKYLLENNADPNIQD-KSGKTALMHACLEKAGPEVVSLLLKSGADLSLQ 114
S A++ + LL+ AD N S + + +K + LL+ GA + ++
Sbjct: 1294 ----SGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1349
Query: 115 DHSSYSALVYAINSEDTETLKVLLSA 140
+ + L A N + +++L+ A
Sbjct: 1350 NKKGNTPLWLAANGGHLDVVQLLVQA 1375
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 58.2 bits (139), Expect = 2e-08
Identities = 46/158 (29%), Positives = 73/158 (46%), Gaps = 31/158 (19%)
Query: 9 SEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKA---- 64
S+ SL +A + + R LL G +NE + GE+ L +AC + + V A
Sbjct: 233 SDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 292
Query: 65 ----------------------KMVKYLLENNADPNIQDKSGKTALMHACLEKAG--PEV 100
K+VK LL + AD N Q +G TAL +AC AG +V
Sbjct: 293 VEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYAC---AGGYVDV 349
Query: 101 VSLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLL 138
V +LL+SGA + + + ++ L+ A ++ E ++LL
Sbjct: 350 VKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLL 387
Score = 57.0 bits (136), Expect = 4e-08
Identities = 42/134 (31%), Positives = 64/134 (47%), Gaps = 9/134 (6%)
Query: 8 SSEGNS-LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKM 66
SS GN+ L A + + ++LLE GA I + N+ G TPLM A HV+ +
Sbjct: 331 SSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVE--------V 382
Query: 67 VKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAI 126
+ LLEN A N K + + K E+V LL++GAD + ++AL+ A
Sbjct: 383 ARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEAC 442
Query: 127 NSEDTETLKVLLSA 140
E ++LL +
Sbjct: 443 MDGHVEVARLLLDS 456
Score = 55.1 bits (131), Expect = 2e-07
Identities = 41/133 (30%), Positives = 61/133 (45%), Gaps = 8/133 (6%)
Query: 8 SSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMV 67
S+ +L A L + LLE GA I + +G TPL++A HV +V
Sbjct: 830 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVG--------VV 881
Query: 68 KYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAIN 127
+ LL+N AD Q + K + EVV LLL GA+ ++ S Y+ L A +
Sbjct: 882 EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 941
Query: 128 SEDTETLKVLLSA 140
+K+LL+A
Sbjct: 942 GGYVNIIKILLNA 954
Score = 54.7 bits (130), Expect = 2e-07
Identities = 48/145 (33%), Positives = 70/145 (48%), Gaps = 17/145 (11%)
Query: 1 MDEGMEISSEGNS----LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHV 56
+D G +++ +S L A + L LL+E GA + E ND G TPLM A + H
Sbjct: 454 LDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGH- 512
Query: 57 DHQSVSKAKMVKYLLENNADPNIQ-DKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQD 115
+MV LL A+ N Q +++ +TAL AC EV L+K+GAD+ L
Sbjct: 513 -------EEMVALLLGQGANINAQTEETQETALTLACC-GGFLEVADFLIKAGADIEL-- 562
Query: 116 HSSYSALVYAINSEDTETLKVLLSA 140
+ L+ A E +K LL+A
Sbjct: 563 -GCSTPLMEAAQEGHLELVKYLLAA 586
Score = 51.2 bits (121), Expect = 2e-06
Identities = 43/158 (27%), Positives = 73/158 (46%), Gaps = 25/158 (15%)
Query: 6 EISSEGNS-LIKAVHQSRLRLTRLLLEGGAYIN-ESNDRGETPLMIAC------------ 51
E++ EG + L++A + + LLL GA IN ++ + ET L +AC
Sbjct: 495 EVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLI 554
Query: 52 ----------KTKHVDHQSVSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVV 101
T ++ ++VKYLL A+ + +G TAL +AC E +V
Sbjct: 555 KAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYAC-ENGHTDVA 613
Query: 102 SLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVLLS 139
+LL++GADL + + L+ A + T++ L+S
Sbjct: 614 DVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLIS 651
Score = 50.1 bits (118), Expect = 5e-06
Identities = 44/140 (31%), Positives = 66/140 (47%), Gaps = 12/140 (8%)
Query: 3 EGMEISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVS 62
E I + L+ A + +++ +LLL A +N + G T L AC +VD
Sbjct: 294 EDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVD----- 348
Query: 63 KAKMVKYLLENNADPNIQDKSGKTALMHACLEKAG-PEVVSLLLKSGADLSLQDHS-SYS 120
+VK LLE+ A +++G T LM A AG EV LLL++GA ++ + S
Sbjct: 349 ---VVKVLLESGASIEDHNENGHTPLMEA--GSAGHVEVARLLLENGAGINTHSNEFKES 403
Query: 121 ALVYAINSEDTETLKVLLSA 140
AL A E ++ LL A
Sbjct: 404 ALTLACYKGHLEMVRFLLEA 423
Score = 47.8 bits (112), Expect = 2e-05
Identities = 39/129 (30%), Positives = 61/129 (47%), Gaps = 10/129 (7%)
Query: 13 SLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLE 72
+L++A + + RLLL+ GA +N D E+PL +A HV+ + L+E
Sbjct: 437 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE--------LAALLIE 488
Query: 73 NNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQ-DHSSYSALVYAINSEDT 131
A + G T LM A E E+V+LLL GA+++ Q + + +AL A
Sbjct: 489 RGASLEEVNDEGYTPLMEAARE-GHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
Query: 132 ETLKVLLSA 140
E L+ A
Sbjct: 548 EVADFLIKA 556
Score = 47.0 bits (110), Expect = 4e-05
Identities = 51/197 (25%), Positives = 84/197 (42%), Gaps = 36/197 (18%)
Query: 14 LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLEN 73
L++A + L L + LL GA ++ + G+T L AC+ H D V LL+
Sbjct: 568 LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADV--------LLQA 619
Query: 74 NADPNIQDKSGKTALMHACLEKAGPE-VVSLLLKSGADLS-LQDHSSYSALVYAINSEDT 131
AD + + G+T LM A +AG V L+ GA+++ ++ ++ L A
Sbjct: 620 GADLEHESEGGRTPLMKAA--RAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 677
Query: 132 ETLKVLLS-----ACKAKGKEVIIITTAKSPCGKHTT---------KQYLNMPPVDIDGC 177
+++LL+ + K ++I AK G HT+ L+ PP D+
Sbjct: 678 AVVELLLAHGADPTHRLKDGSTMLIEAAK---GGHTSVVCYLLDYPNNLLSAPPPDV--- 731
Query: 178 HSPATCTTPSEIDIKTA 194
T TP D+ A
Sbjct: 732 ----TQLTPPSHDLNRA 744
Score = 43.5 bits (101), Expect = 5e-04
Identities = 40/141 (28%), Positives = 61/141 (43%), Gaps = 19/141 (13%)
Query: 1 MDEGMEI------SSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTK 54
+D+G ++ SS +L A + + LL+ GA+I+ N +G TPL +A
Sbjct: 1054 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGG 1113
Query: 55 HVDHQSVSKAKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQ 114
H+D +V+ L++ AD + D T LM A K +VV L+K Q
Sbjct: 1114 HLD--------VVQLLVQAGADVDAADNRKITPLM-AAFRKGHVKVVRYLVKE----VNQ 1160
Query: 115 DHSSYSALVYAINSEDTETLK 135
S + Y D E LK
Sbjct: 1161 FPSDSECMRYIATITDKEMLK 1181
Score = 43.1 bits (100), Expect = 6e-04
Identities = 44/143 (30%), Positives = 67/143 (46%), Gaps = 16/143 (11%)
Query: 9 SEGNSLIKAVHQSRLRLTRLLLEGGAYINE--SNDRGETPLMIACKTKHVDHQSVSKAKM 66
S+ L A + + ++LL GA IN + G +PLM+A H
Sbjct: 931 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHT--------AA 982
Query: 67 VKYLLENNADPNIQDKSGK-TALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYA 125
VK LL+ +D N Q ++ + TAL AC + EVVSLLL A++ + + + L+ A
Sbjct: 983 VKLLLDMGSDINAQIETNRNTALTLACFQ-GRTEVVSLLLDRKANVEHRAKTGLTPLMEA 1041
Query: 126 INSEDTETLKVLLSACKAKGKEV 148
+ E +VLL KG +V
Sbjct: 1042 ASGGYAEVGRVLLD----KGADV 1060
Score = 37.4 bits (85), Expect = 0.033
Identities = 35/146 (23%), Positives = 63/146 (43%), Gaps = 14/146 (9%)
Query: 1 MDEGMEISSE-----GNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKH 55
+D G +I+++ +L A Q R + LLL+ A + G TPLM A
Sbjct: 987 LDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAA---- 1042
Query: 56 VDHQSVSKAKMVKYLLENNADPNIQD-KSGKTALMHACLEKAGPEVVSLLLKSGADLSLQ 114
S A++ + LL+ AD N S + + +K + LL+ GA + ++
Sbjct: 1043 ----SGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR 1098
Query: 115 DHSSYSALVYAINSEDTETLKVLLSA 140
+ + L A N + +++L+ A
Sbjct: 1099 NKKGNTPLWLAANGGHLDVVQLLVQA 1124
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 57.8 bits (138), Expect = 2e-08
Identities = 40/113 (35%), Positives = 56/113 (49%), Gaps = 9/113 (7%)
Query: 13 SLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLE 72
+L A + +L + RLLLE GA + + N RG PL + H ++V LL
Sbjct: 1037 ALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGH--------WQIVDLLLT 1088
Query: 73 NNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYA 125
+ AD N+ DK G+T LM A E V LL GA ++L D +AL +A
Sbjct: 1089 HGADVNMADKQGRTPLMMAASE-GHLGTVDFLLAQGASIALMDKEGLTALSWA 1140
Score = 53.9 bits (128), Expect = 3e-07
Identities = 41/125 (32%), Positives = 58/125 (46%), Gaps = 9/125 (7%)
Query: 14 LIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLEN 73
L V Q ++ LLL GA +N ++ +G TPLM+A H+ V +LL
Sbjct: 1071 LFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLG--------TVDFLLAQ 1122
Query: 74 NADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTET 133
A + DK G TAL ACL K VV L+ +GA D + + L A D E
Sbjct: 1123 GASIALMDKEGLTALSWACL-KGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEV 1181
Query: 134 LKVLL 138
++ L+
Sbjct: 1182 VQFLV 1186
Score = 43.1 bits (100), Expect = 6e-04
Identities = 41/150 (27%), Positives = 67/150 (44%), Gaps = 16/150 (10%)
Query: 6 EISSEGNSLIKAVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAK 65
E+ + L H + LLLE GA ++ S++ G TPL A ++
Sbjct: 881 EVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYL--------S 932
Query: 66 MVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQ-------DHSS 118
+V L + A + DK+G+ AL+HA L + EVV L++ ++ Q H+
Sbjct: 933 IVVLLCKKRAKVDHLDKNGQCALVHAAL-RGHLEVVKFLIQCDWTMAGQQQGVFKKSHAI 991
Query: 119 YSALVYAINSEDTETLKVLLSACKAKGKEV 148
AL+ A + TE + LL + +EV
Sbjct: 992 QQALIAAASMGYTEIVSYLLDLPEKDEEEV 1021
Score = 42.0 bits (97), Expect = 0.001
Identities = 41/137 (29%), Positives = 68/137 (49%), Gaps = 15/137 (10%)
Query: 8 SSEGNSL----IKAVHQSRLRLTRLLLEGGAYINESND-RGETPLMIACKTKHVDHQSVS 62
S+EG S+ ++ ++ ++++RLL+ GGA IN + P++ C H+ +
Sbjct: 844 STEGLSMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPIL--CVQSHLGY---- 897
Query: 63 KAKMVKYLLENNADPNIQDKSGKTALMHACLEKAG-PEVVSLLLKSGADLSLQDHSSYSA 121
+MV LLE A+ + +SG T L +A AG +V LL K A + D + A
Sbjct: 898 -TEMVALLLEFGANVDASSESGLTPLGYAA--AAGYLSIVVLLCKKRAKVDHLDKNGQCA 954
Query: 122 LVYAINSEDTETLKVLL 138
LV+A E +K L+
Sbjct: 955 LVHAALRGHLEVVKFLI 971
>gi|209977003 ANKRD26-like family C, member 3 [Homo sapiens]
Length = 545
Score = 57.4 bits (137), Expect = 3e-08
Identities = 45/148 (30%), Positives = 77/148 (52%), Gaps = 15/148 (10%)
Query: 11 GNSLIK-AVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKY 69
GN+ + A++ + + LL GA I N G TPL++ + K ++VK+
Sbjct: 276 GNTALHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQ--------KQQVVKF 327
Query: 70 LLENNADPNIQDKSGKTALMHA-CLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINS 128
L++ A+ N D+ G+TAL+ A C A +VSLLL+ D+S QD S +A YA++S
Sbjct: 328 LIKKKANLNALDRYGRTALILAVCCGSAS--IVSLLLEQNIDVSSQDLSGQTAREYAVSS 385
Query: 129 EDTETLKVLLSACKAKGKEVIIITTAKS 156
++L K K+++ +++ S
Sbjct: 386 RHNVICQLL---SDYKEKQILKVSSENS 410
Score = 43.9 bits (102), Expect = 4e-04
Identities = 41/156 (26%), Positives = 69/156 (44%), Gaps = 18/156 (11%)
Query: 25 LTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKYLLENNADPNIQDKSG 84
+ +LLL+ +N +++ T L TK V Q A M LLE+ DPNI D+ G
Sbjct: 225 VVKLLLDRRCQLNILDNKKRTAL-----TKAVQCQEDECALM---LLEHGTDPNIPDEYG 276
Query: 85 KTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTETLKVL------L 138
TAL H + + LL GAD+ ++ + L+ ++ + + +K L L
Sbjct: 277 NTAL-HYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANL 335
Query: 139 SACKAKGKEVIIITTAKSPCGKHTTKQYLNMPPVDI 174
+A G+ +I+ CG + L +D+
Sbjct: 336 NALDRYGRTALILAVC---CGSASIVSLLLEQNIDV 368
Score = 35.8 bits (81), Expect = 0.096
Identities = 22/65 (33%), Positives = 33/65 (50%), Gaps = 1/65 (1%)
Query: 74 NADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTET 133
+ D N +DK +TAL H EVV LLL L++ D+ +AL A+ ++ E
Sbjct: 200 DTDMNKKDKQKRTAL-HLASANGNSEVVKLLLDRRCQLNILDNKKRTALTKAVQCQEDEC 258
Query: 134 LKVLL 138
+LL
Sbjct: 259 ALMLL 263
>gi|212549546 ANKRD26-like family B, member 2 [Homo sapiens]
Length = 542
Score = 57.4 bits (137), Expect = 3e-08
Identities = 47/136 (34%), Positives = 71/136 (52%), Gaps = 13/136 (9%)
Query: 11 GNSLIK-AVHQSRLRLTRLLLEGGAYINESNDRGETPLMIACKTKHVDHQSVSKAKMVKY 69
GN+ + AVH + + LL GA I N G TPL++ + K ++VK+
Sbjct: 239 GNTTLHYAVHNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQ--------KQQVVKF 290
Query: 70 LLENNADPNIQDKSGKTALMHA-CLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINS 128
L++ A+ N D+ G+TAL+ A C A +V+LLL+ D+S QD S +A YA++S
Sbjct: 291 LIKKKANLNALDRYGRTALILAVCCGSAS--IVNLLLEQNVDVSSQDLSGQTAREYAVSS 348
Query: 129 EDTETLKVLLSACKAK 144
+ LLS K K
Sbjct: 349 HH-HVICELLSDYKEK 363
Score = 42.4 bits (98), Expect = 0.001
Identities = 25/75 (33%), Positives = 43/75 (57%), Gaps = 1/75 (1%)
Query: 64 AKMVKYLLENNADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALV 123
+++V+ LL+ N+ D +TAL+ A ++ E V +LL+ GAD ++ D + L
Sbjct: 186 SEVVQLLLDRRCQLNVLDNKKRTALIKA-VQCQEDECVLMLLEHGADQNIPDEYGNTTLH 244
Query: 124 YAINSEDTETLKVLL 138
YA+++ED K LL
Sbjct: 245 YAVHNEDKLMAKALL 259
Score = 37.4 bits (85), Expect = 0.033
Identities = 22/65 (33%), Positives = 35/65 (53%), Gaps = 1/65 (1%)
Query: 74 NADPNIQDKSGKTALMHACLEKAGPEVVSLLLKSGADLSLQDHSSYSALVYAINSEDTET 133
+ D N +DK +TAL H EVV LLL L++ D+ +AL+ A+ ++ E
Sbjct: 163 DTDMNKRDKQKRTAL-HLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAVQCQEDEC 221
Query: 134 LKVLL 138
+ +LL
Sbjct: 222 VLMLL 226
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,139,678
Number of Sequences: 37866
Number of extensions: 1035356
Number of successful extensions: 5067
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 166
Number of HSP's successfully gapped in prelim test: 187
Number of HSP's that attempted gapping in prelim test: 3403
Number of HSP's gapped (non-prelim): 1158
length of query: 514
length of database: 18,247,518
effective HSP length: 107
effective length of query: 407
effective length of database: 14,195,856
effective search space: 5777713392
effective search space used: 5777713392
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.