BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|5174695 aldo-keto reductase family 1, member D1 [Homo sapiens] (326 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|5174695 aldo-keto reductase family 1, member D1 [Homo sapiens] 671 0.0 gi|5453543 aldo-keto reductase family 1, member C1 [Homo sapiens] 397 e-111 gi|45446745 aldo-keto reductase family 1, member C2 [Homo sapiens] 395 e-110 gi|4503285 aldo-keto reductase family 1, member C2 [Homo sapiens] 395 e-110 gi|24497585 aldo-keto reductase family 1, member C4 [Homo sapiens] 387 e-108 gi|24497583 aldo-keto reductase family 1, member C3 [Homo sapiens] 384 e-107 gi|4502049 aldo-keto reductase family 1, member B1 [Homo sapiens] 332 2e-91 gi|223468663 aldo-keto reductase family 1, member B10 [Homo sapi... 325 3e-89 gi|122937516 aldo-keto reductase family 1, member B10-like [Homo... 306 2e-83 gi|93277124 aldo-keto reductase family 1, member C-like 2 [Homo ... 278 4e-75 gi|24497577 aldo-keto reductase family 1, member A1 [Homo sapiens] 270 1e-72 gi|5174391 aldo-keto reductase family 1, member A1 [Homo sapiens] 270 1e-72 gi|207028673 hypothetical protein LOC100134257 [Homo sapiens] 141 9e-34 gi|41327764 aldo-keto reductase family 7, member A2 [Homo sapiens] 42 7e-04 gi|19923584 modulator of apoptosis 1 [Homo sapiens] 38 0.011 gi|13129124 caspase recruitment domain protein 14 isoform 1 [Hom... 30 2.2 gi|193211614 NAD(P) dependent steroid dehydrogenase-like [Homo s... 30 2.9 gi|8393516 NAD(P) dependent steroid dehydrogenase-like [Homo sap... 30 2.9 gi|4504825 potassium voltage-gated channel, shaker-related subfa... 30 2.9 gi|27436969 potassium voltage-gated channel, shaker-related subf... 30 2.9 gi|4504011 glutamate-cysteine ligase regulatory protein [Homo sa... 30 3.8 gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precurs... 30 3.8 gi|74316006 CNKSR family member 3 [Homo sapiens] 29 5.0 gi|27436966 potassium voltage-gated channel, shaker-related subf... 29 6.5 gi|148664197 coiled-coil domain containing 40 [Homo sapiens] 29 6.5 >gi|5174695 aldo-keto reductase family 1, member D1 [Homo sapiens] Length = 326 Score = 671 bits (1732), Expect = 0.0 Identities = 326/326 (100%), Positives = 326/326 (100%) Query: 1 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN 60 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN Sbjct: 1 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN 60 Query: 61 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE 120 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE Sbjct: 61 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE 120 Query: 121 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL 180 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL Sbjct: 121 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL 180 Query: 181 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK 240 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK Sbjct: 181 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK 240 Query: 241 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE 300 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE Sbjct: 241 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE 300 Query: 301 ALNKNVRFVELLMWRDHPEYPFHDEY 326 ALNKNVRFVELLMWRDHPEYPFHDEY Sbjct: 301 ALNKNVRFVELLMWRDHPEYPFHDEY 326 >gi|5453543 aldo-keto reductase family 1, member C1 [Homo sapiens] Length = 323 Score = 397 bits (1021), Expect = e-111 Identities = 186/317 (58%), Positives = 244/317 (76%), Gaps = 1/317 (0%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + L+DG+ +P++G GTY+ P PK + K+AI+ G+RHID A++Y NE +VG AIR Sbjct: 8 VKLNDGHFMPVLGFGTYA-PAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIR 66 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 KIA+G V+REDIFY KLW +H PE+VRP LER+L+ LQLDYVDLY+I P++ KPG+ Sbjct: 67 SKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGE 126 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 E+ P+DENGK L+ +LCATWEA+E CKDAGL KS+GVSNFNRRQLE+ILNKPGLK+KP Sbjct: 127 EVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKP 186 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V NQVECHPYF Q KLL FC+ DIV+ AYS LG+ R WV+ +SP LL+D +L +L K Sbjct: 187 VCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAK 246 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 ++ +T A I LR+ +QRGVVV+ KS+N +RI++N Q+F+F LT EEMK I+ LN+NVR++ Sbjct: 247 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYL 306 Query: 310 ELLMWRDHPEYPFHDEY 326 L ++ P YPF DEY Sbjct: 307 TLDIFAGPPNYPFSDEY 323 >gi|45446745 aldo-keto reductase family 1, member C2 [Homo sapiens] Length = 323 Score = 395 bits (1014), Expect = e-110 Identities = 185/317 (58%), Positives = 243/317 (76%), Gaps = 1/317 (0%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + L+DG+ +P++G GTY+ P PK +VK+AI+ G+ HID A++Y NE +VG AIR Sbjct: 8 VKLNDGHFMPVLGFGTYA-PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIR 66 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 KIA+G V+REDIFY KLW+ +H PE+VRP LER+L+ LQLDYVDLY+I P++ KPG+ Sbjct: 67 SKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGE 126 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 E+ P+DENGK L+ +LCATWEAME CKDAGL KS+GVSNFN R LE+ILNKPGLK+KP Sbjct: 127 EVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKP 186 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V NQVECHPYF Q KLL FC+ DIV+ AYS LG+ R WV+ +SP LL+D +L +L K Sbjct: 187 VCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAK 246 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 ++ +T A I LR+ +QRGVVV+ KS+N +RI++N Q+F+F LT EEMK I+ LN+NVR++ Sbjct: 247 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYL 306 Query: 310 ELLMWRDHPEYPFHDEY 326 L ++ P YPF DEY Sbjct: 307 TLDIFAGPPNYPFSDEY 323 >gi|4503285 aldo-keto reductase family 1, member C2 [Homo sapiens] Length = 323 Score = 395 bits (1014), Expect = e-110 Identities = 185/317 (58%), Positives = 243/317 (76%), Gaps = 1/317 (0%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + L+DG+ +P++G GTY+ P PK +VK+AI+ G+ HID A++Y NE +VG AIR Sbjct: 8 VKLNDGHFMPVLGFGTYA-PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIR 66 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 KIA+G V+REDIFY KLW+ +H PE+VRP LER+L+ LQLDYVDLY+I P++ KPG+ Sbjct: 67 SKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGE 126 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 E+ P+DENGK L+ +LCATWEAME CKDAGL KS+GVSNFN R LE+ILNKPGLK+KP Sbjct: 127 EVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKP 186 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V NQVECHPYF Q KLL FC+ DIV+ AYS LG+ R WV+ +SP LL+D +L +L K Sbjct: 187 VCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAK 246 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 ++ +T A I LR+ +QRGVVV+ KS+N +RI++N Q+F+F LT EEMK I+ LN+NVR++ Sbjct: 247 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYL 306 Query: 310 ELLMWRDHPEYPFHDEY 326 L ++ P YPF DEY Sbjct: 307 TLDIFAGPPNYPFSDEY 323 >gi|24497585 aldo-keto reductase family 1, member C4 [Homo sapiens] Length = 323 Score = 387 bits (993), Expect = e-108 Identities = 181/318 (56%), Positives = 239/318 (75%), Gaps = 1/318 (0%) Query: 9 RIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAI 68 R+ L+DG+ +P++G GTY+ P+ P+ K+AI+ G+RHID AY+Y NE +VG AI Sbjct: 7 RVELNDGHFMPVLGFGTYAPPE-VPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAI 65 Query: 69 REKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPG 128 R KIA+G V+REDIFY KLW T P+MV+P LE +L+ LQLDYVDLY++ PMA KPG Sbjct: 66 RSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPG 125 Query: 129 DEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHK 188 + P+DENGK ++ +L ATWE ME CKDAGL KS+GVSNFN RQLE+ILNKPGLK+K Sbjct: 126 ETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKPGLKYK 185 Query: 189 PVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLG 248 PV NQVECHPY Q KLL FC+ DIV+ A+S LGT R+ +WV+ +SP LL+D +L +L Sbjct: 186 PVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALA 245 Query: 249 KRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRF 308 K++ +T A I LR+ +QRGVVV+ KS+N +RI+EN Q+F+F LT E+MK ++ LN+N R+ Sbjct: 246 KKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRY 305 Query: 309 VELLMWRDHPEYPFHDEY 326 V + DHP+YPF DEY Sbjct: 306 VVMDFLMDHPDYPFSDEY 323 >gi|24497583 aldo-keto reductase family 1, member C3 [Homo sapiens] Length = 323 Score = 384 bits (985), Expect = e-107 Identities = 178/317 (56%), Positives = 239/317 (75%), Gaps = 1/317 (0%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + L+DG+ +P++G GTY+ P+ P+ K+AI+ G+RHID A++Y NE +VG AIR Sbjct: 8 VKLNDGHFMPVLGFGTYAPPE-VPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIR 66 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 KIA+G V+REDIFY KLW+T H PE+VRP LE +L+ QLDYVDLY+I PM+ KPG+ Sbjct: 67 SKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGE 126 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 E+ P DENGK ++ +LC TWEAME CKDAGL KS+GVSNFNRRQLE+ILNKPGLK+KP Sbjct: 127 ELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKP 186 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V NQVECHPYF + KLL FC+ DIV+ AYS LG+ R+ WV+ +SP LL+D +L +L K Sbjct: 187 VCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAK 246 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 ++ +T A I LR+ +QRGVVV+ KS+N +RI++N Q+F+F LT E+MK I+ L++N+ + Sbjct: 247 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYF 306 Query: 310 ELLMWRDHPEYPFHDEY 326 + HP YP+ DEY Sbjct: 307 NSDSFASHPNYPYSDEY 323 >gi|4502049 aldo-keto reductase family 1, member B1 [Homo sapiens] Length = 316 Score = 332 bits (852), Expect = 2e-91 Identities = 159/318 (50%), Positives = 221/318 (69%), Gaps = 5/318 (1%) Query: 9 RIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAI 68 R+ L++G +PI+GLGT+ +P G +VKVAID GYRHID A++YQNE+EVG AI Sbjct: 4 RLLLNNGAKMPILGLGTWK----SPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAI 59 Query: 69 REKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPG 128 +EK+ E V+RE++F KLW T H +V+ ++TL L+LDY+DLY+I P FKPG Sbjct: 60 QEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPG 119 Query: 129 DEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHK 188 E +P DE+G + +N+ TW AME D GLVK++G+SNFN Q+E+ILNKPGLK+K Sbjct: 120 KEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYK 179 Query: 189 PVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLG 248 P NQ+ECHPY TQ KL+++CQ IV+TAYSPLG+ P W P LL+D + ++ Sbjct: 180 PAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP-WAKPEDPSLLEDPRIKAIA 238 Query: 249 KRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRF 308 ++NKT AQ+++RF +QR +VVIPKS ERI ENF++FDF L+ ++M + + N+N R Sbjct: 239 AKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRV 298 Query: 309 VELLMWRDHPEYPFHDEY 326 LL H +YPFH+E+ Sbjct: 299 CALLSCTSHKDYPFHEEF 316 >gi|223468663 aldo-keto reductase family 1, member B10 [Homo sapiens] Length = 316 Score = 325 bits (833), Expect = 3e-89 Identities = 162/317 (51%), Positives = 213/317 (67%), Gaps = 5/317 (1%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + LS +PI+GLGT+ P K A VKVAID GYRHID AY+YQNEHEVGEAI+ Sbjct: 5 VELSTKAKMPIVGLGTWKSPLGKVKEA----VKVAIDAGYRHIDCAYVYQNEHEVGEAIQ 60 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 EKI E V+RED+F KLW T +VR E+TL+ L+L Y+D+Y+I P FK GD Sbjct: 61 EKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD 120 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 +++P+D+ G + K+ WEAME D GLVK+LGVSNF+ Q+E +LNKPGLK+KP Sbjct: 121 DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP 180 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V+NQVECHPY TQ KL+++C I +TAYSPLG+ P W P LL+D + + Sbjct: 181 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRP-WAKPEDPSLLEDPKIKEIAA 239 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 ++ KTAAQ+++RF+IQR V+VIPKS RI EN Q+FDF L++EEM I + N+N R Sbjct: 240 KHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRAC 299 Query: 310 ELLMWRDHPEYPFHDEY 326 +L +YPF+ EY Sbjct: 300 NVLQSSHLEDYPFNAEY 316 >gi|122937516 aldo-keto reductase family 1, member B10-like [Homo sapiens] Length = 316 Score = 306 bits (784), Expect = 2e-83 Identities = 154/317 (48%), Positives = 203/317 (64%), Gaps = 5/317 (1%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + LS +PI+GLGT+ K A VKVAID YRHID AY Y+N+HEVGEAI+ Sbjct: 5 VELSTKAKMPIVGLGTWRSLLGKVKEA----VKVAIDAEYRHIDCAYFYENQHEVGEAIQ 60 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 EKI E V RED+F K+W T +VR E+TL+ L+L Y+D+Y+I P FK GD Sbjct: 61 EKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD 120 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 + +P+D+ G + K WEAME D GLVK+LGVSNFN Q+E +LNKPGLK+KP Sbjct: 121 DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKP 180 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V+NQVECHPY TQ KL+++C I +TAYSPLG+ P W P LL+D + + Sbjct: 181 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRP-WAKPEDPSLLEDPKIKEIAA 239 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 ++ KT AQ+++RF+IQR V VIPKS I EN Q+FDF L++EEM I + N+N R Sbjct: 240 KHKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAF 299 Query: 310 ELLMWRDHPEYPFHDEY 326 + + ++PF EY Sbjct: 300 DFKEFSHLEDFPFDAEY 316 >gi|93277124 aldo-keto reductase family 1, member C-like 2 [Homo sapiens] Length = 320 Score = 278 bits (712), Expect = 4e-75 Identities = 146/328 (44%), Positives = 198/328 (60%), Gaps = 30/328 (9%) Query: 18 IPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIREKIAEGKV 77 IP +GL ++ K++P G +VK AID GYRH D AY Y NE EVG IR KI EG V Sbjct: 4 IPAVGLSSW---KASP-GKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAV 59 Query: 78 RREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIY----- 132 RRED+F KLW T H +V ++L+ L+L+Y+DLY+I PM FKP + Sbjct: 60 RREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCS 119 Query: 133 --------------PRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLEL 178 P DE+ + ++ TWEAME GLVK++GVSNFN QLE Sbjct: 120 ELSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLER 179 Query: 179 ILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPL 238 +LNKPGL+ KP++NQ+ECHPY TQ L+ FCQ D+ +TAY PLG S + L Sbjct: 180 LLNKPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGV-------DL 232 Query: 239 LKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKD 298 + + ++ + K + K+ AQI++RF IQR V+VIP S IKEN Q+FDF LT+ +M + Sbjct: 233 IDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDN 292 Query: 299 IEALNKNVRFVELLMWRDHPEYPFHDEY 326 I +LN+N+R + ++H +YPFH EY Sbjct: 293 ILSLNRNLRLAMFPITKNHKDYPFHIEY 320 >gi|24497577 aldo-keto reductase family 1, member A1 [Homo sapiens] Length = 325 Score = 270 bits (690), Expect = 1e-72 Identities = 145/331 (43%), Positives = 211/331 (63%), Gaps = 17/331 (5%) Query: 6 ASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVG 65 A+ + L G +P+IGLGT+ KS P G +VK A+ GYRHID A IY NE E+G Sbjct: 2 AASCVLLHTGQKMPLIGLGTW---KSEP-GQVKAAVKYALSVGYRHIDCAAIYGNEPEIG 57 Query: 66 EAIREKIAEGK-VRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMA 124 EA++E + GK V RE++F KLW T H PE V P L +TL LQL+Y+DLY++ P A Sbjct: 58 EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 117 Query: 125 FKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPG 184 F+ GD +P++ +G Y ++ TW+A+EA GLV++LG+SNFN RQ++ IL+ Sbjct: 118 FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 177 Query: 185 LKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALL 244 + +P QVECHPY Q +L+ CQ + +TAYSPLG+S + W + P LL++ ++ Sbjct: 178 V--RPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVV 234 Query: 245 NSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNK 304 +L ++Y ++ AQI+LR+ +QR V+ IPKS RI +N ++FDF+ + EEMK + ALNK Sbjct: 235 LALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK 294 Query: 305 NVRFVELLMWRD---------HPEYPFHDEY 326 N R++ ++ D HP YPF+D Y Sbjct: 295 NWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY 325 >gi|5174391 aldo-keto reductase family 1, member A1 [Homo sapiens] Length = 325 Score = 270 bits (690), Expect = 1e-72 Identities = 145/331 (43%), Positives = 211/331 (63%), Gaps = 17/331 (5%) Query: 6 ASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVG 65 A+ + L G +P+IGLGT+ KS P G +VK A+ GYRHID A IY NE E+G Sbjct: 2 AASCVLLHTGQKMPLIGLGTW---KSEP-GQVKAAVKYALSVGYRHIDCAAIYGNEPEIG 57 Query: 66 EAIREKIAEGK-VRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMA 124 EA++E + GK V RE++F KLW T H PE V P L +TL LQL+Y+DLY++ P A Sbjct: 58 EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 117 Query: 125 FKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPG 184 F+ GD +P++ +G Y ++ TW+A+EA GLV++LG+SNFN RQ++ IL+ Sbjct: 118 FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 177 Query: 185 LKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALL 244 + +P QVECHPY Q +L+ CQ + +TAYSPLG+S + W + P LL++ ++ Sbjct: 178 V--RPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVV 234 Query: 245 NSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNK 304 +L ++Y ++ AQI+LR+ +QR V+ IPKS RI +N ++FDF+ + EEMK + ALNK Sbjct: 235 LALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK 294 Query: 305 NVRFVELLMWRD---------HPEYPFHDEY 326 N R++ ++ D HP YPF+D Y Sbjct: 295 NWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY 325 >gi|207028673 hypothetical protein LOC100134257 [Homo sapiens] Length = 139 Score = 141 bits (355), Expect = 9e-34 Identities = 64/117 (54%), Positives = 88/117 (75%), Gaps = 1/117 (0%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + L+DG+ +P++G GTY+ P PK +VK+AI+ G+ HID A++Y NE +VG AIR Sbjct: 8 VKLNDGHFMPVLGFGTYA-PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIR 66 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFK 126 KIA+G V+REDIFY KLW+ +H PE+VRP LER+L+ LQLDYVDLY+I P++ K Sbjct: 67 SKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK 123 >gi|41327764 aldo-keto reductase family 7, member A2 [Homo sapiens] Length = 359 Score = 42.0 bits (97), Expect = 7e-04 Identities = 47/178 (26%), Positives = 77/178 (43%), Gaps = 15/178 (8%) Query: 23 LGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIY---QNEHEVGEAIREKIAEGKVRR 79 LGT + A A +V+ ++ G+ +D A++Y Q+E +G + + G R Sbjct: 42 LGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILG-GLGLGLGGGDCRV 100 Query: 80 EDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPR----D 135 + + P+ VR LE +L+ LQ VDL+ + P P +E Sbjct: 101 KIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLH 160 Query: 136 ENGKWLYHKSNLCATWEAME---ACKDAGLVKSL---GVSNFNRRQLELILNKPGLKH 187 + GK++ + A+WE E CK G + G+ N RQ+E L P L+H Sbjct: 161 QEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETEL-FPCLRH 217 >gi|19923584 modulator of apoptosis 1 [Homo sapiens] Length = 351 Score = 38.1 bits (87), Expect = 0.011 Identities = 23/78 (29%), Positives = 38/78 (48%), Gaps = 10/78 (12%) Query: 94 VPEMVRPTLERTLRVLQ-----LDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLC 148 +PEM P L + L LQ L Y L + + +PG+E E G+W++H + + Sbjct: 138 IPEMWAPMLAQALEALQPALQCLKYKKLRVFSGRESPEPGEE-----EFGRWMFHTTQMI 192 Query: 149 ATWEAMEACKDAGLVKSL 166 W+ + K L++SL Sbjct: 193 KAWQVPDVEKRRRLLESL 210 >gi|13129124 caspase recruitment domain protein 14 isoform 1 [Homo sapiens] Length = 1004 Score = 30.4 bits (67), Expect = 2.2 Identities = 21/75 (28%), Positives = 32/75 (42%), Gaps = 6/75 (8%) Query: 40 SVKVAIDTGYRHIDGAYIYQNEHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVR 99 S K+ + G++ Y+ Q E+E + I EG+V G+ W T H E + Sbjct: 842 SEKLCLLQGFKKCLAEYLSQEEYEAWSQRGDIIQEGEVSG------GRCWVTRHAVESLM 895 Query: 100 PTLERTLRVLQLDYV 114 L +QLD V Sbjct: 896 EKNTHALLDVQLDSV 910 >gi|193211614 NAD(P) dependent steroid dehydrogenase-like [Homo sapiens] Length = 373 Score = 30.0 bits (66), Expect = 2.9 Identities = 21/75 (28%), Positives = 39/75 (52%), Gaps = 3/75 (4%) Query: 133 PRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSN 192 P N K L+++ N T +E CK+AG+ K + S+ + E + K G + P + Sbjct: 108 PPSSNNKELFYRVNYIGTKNVIETCKEAGVQKLILTSSAS-VIFEGVDIKNGTEDLPYA- 165 Query: 193 QVECHPYFTQPKLLK 207 ++ Y+T+ K+L+ Sbjct: 166 -MKPIDYYTETKILQ 179 >gi|8393516 NAD(P) dependent steroid dehydrogenase-like [Homo sapiens] Length = 373 Score = 30.0 bits (66), Expect = 2.9 Identities = 21/75 (28%), Positives = 39/75 (52%), Gaps = 3/75 (4%) Query: 133 PRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSN 192 P N K L+++ N T +E CK+AG+ K + S+ + E + K G + P + Sbjct: 108 PPSSNNKELFYRVNYIGTKNVIETCKEAGVQKLILTSSAS-VIFEGVDIKNGTEDLPYA- 165 Query: 193 QVECHPYFTQPKLLK 207 ++ Y+T+ K+L+ Sbjct: 166 -MKPIDYYTETKILQ 179 >gi|4504825 potassium voltage-gated channel, shaker-related subfamily, beta member 2 isoform 1 [Homo sapiens] Length = 367 Score = 30.0 bits (66), Expect = 2.9 Identities = 49/202 (24%), Positives = 80/202 (39%), Gaps = 40/202 (19%) Query: 15 GNSIPIIGLGTYSEPKSTPKGACATSVK-VAIDTGYRHIDGAYIY---QNEHEVGEAIRE 70 G + +GLGT+ A + +A D G D A +Y + E +G I++ Sbjct: 46 GLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKK 105 Query: 71 K--IAEGKVRREDIFYCGKL-----WATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPM 123 K V IF+ GK + H+ E ++ +LER LQL+YVD+ P Sbjct: 106 KGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLER----LQLEYVDVVFANRP- 160 Query: 124 AFKPGDEIYPRDENGKWLYHKSNL-------CATWEAMEACKDAGLVKSLGVS------- 169 D P +E + + H N + W +ME + + + ++ Sbjct: 161 -----DPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQA 215 Query: 170 ---NFNRRQLELILNKPGLKHK 188 F R ++E+ L P L HK Sbjct: 216 EYHMFQREKVEVQL--PELFHK 235 >gi|27436969 potassium voltage-gated channel, shaker-related subfamily, beta member 2 isoform 2 [Homo sapiens] Length = 353 Score = 30.0 bits (66), Expect = 2.9 Identities = 49/202 (24%), Positives = 80/202 (39%), Gaps = 40/202 (19%) Query: 15 GNSIPIIGLGTYSEPKSTPKGACATSVK-VAIDTGYRHIDGAYIY---QNEHEVGEAIRE 70 G + +GLGT+ A + +A D G D A +Y + E +G I++ Sbjct: 32 GLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKK 91 Query: 71 K--IAEGKVRREDIFYCGKL-----WATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPM 123 K V IF+ GK + H+ E ++ +LER LQL+YVD+ P Sbjct: 92 KGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLER----LQLEYVDVVFANRP- 146 Query: 124 AFKPGDEIYPRDENGKWLYHKSNL-------CATWEAMEACKDAGLVKSLGVS------- 169 D P +E + + H N + W +ME + + + ++ Sbjct: 147 -----DPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQA 201 Query: 170 ---NFNRRQLELILNKPGLKHK 188 F R ++E+ L P L HK Sbjct: 202 EYHMFQREKVEVQL--PELFHK 221 >gi|4504011 glutamate-cysteine ligase regulatory protein [Homo sapiens] Length = 274 Score = 29.6 bits (65), Expect = 3.8 Identities = 20/71 (28%), Positives = 34/71 (47%), Gaps = 3/71 (4%) Query: 151 WEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQ-PKLLKFC 209 WE +E + + ++G S+ ++ QLE + + KP SNQV P L F Sbjct: 147 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQ--WAQVKPNSNQVNLASCCVMPPDLTAFA 204 Query: 210 QQHDIVITAYS 220 +Q DI + ++ Sbjct: 205 KQFDIQLLTHN 215 >gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precursor [Homo sapiens] Length = 913 Score = 29.6 bits (65), Expect = 3.8 Identities = 19/80 (23%), Positives = 37/80 (46%), Gaps = 4/80 (5%) Query: 129 DEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELI----LNKPG 184 D +Y + L+ + L + +E + C D G++ +L SN + + L+ L +P Sbjct: 758 DYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPV 817 Query: 185 LKHKPVSNQVECHPYFTQPK 204 + + N +EC +T K Sbjct: 818 ICYSTYHNCLECSGNYTASK 837 >gi|74316006 CNKSR family member 3 [Homo sapiens] Length = 555 Score = 29.3 bits (64), Expect = 5.0 Identities = 20/59 (33%), Positives = 29/59 (49%), Gaps = 8/59 (13%) Query: 90 ATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLC 148 AT PE T++ +L+ + +DLYI P PRDENG ++Y S+ C Sbjct: 321 ATTQSPES---TMDTSLKKEKSAILDLYIPPPPAV-----PYSPRDENGSFVYGGSSKC 371 >gi|27436966 potassium voltage-gated channel, shaker-related subfamily, beta member 1 isoform 1 [Homo sapiens] Length = 419 Score = 28.9 bits (63), Expect = 6.5 Identities = 41/168 (24%), Positives = 69/168 (41%), Gaps = 27/168 (16%) Query: 8 HRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVK-VAIDTGYRHIDGAYIY---QNEHE 63 HR G + +GLGT+ A + +A ++G D A +Y + E Sbjct: 91 HRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVI 150 Query: 64 VGEAIREKIAEGKVRREDIFYCGKLW-----------ATNHVPEMVRPTLERTLRVLQLD 112 +G I++K RR + KL+ + H+ E ++ +L+R LQL+ Sbjct: 151 LGSIIKKK----GWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQR----LQLE 202 Query: 113 YVDLYIIEVPMAFKPGDEIYPR----DENGKWLYHKSNLCATWEAMEA 156 YVD+ P + P +EI G +Y ++ + E MEA Sbjct: 203 YVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEA 250 >gi|148664197 coiled-coil domain containing 40 [Homo sapiens] Length = 1142 Score = 28.9 bits (63), Expect = 6.5 Identities = 23/99 (23%), Positives = 45/99 (45%), Gaps = 5/99 (5%) Query: 232 NVSSPPLLKDALLNSLGKRYNKTAAQI-----VLRFNIQRGVVVIPKSFNLERIKENFQI 286 NVSS L K L+ + ++ A + + R N+ V + + +L+ +KE + Sbjct: 1025 NVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKEGRYV 1084 Query: 287 FDFSLTEEEMKDIEALNKNVRFVELLMWRDHPEYPFHDE 325 F F + + + + L+K + + ++ R EYP E Sbjct: 1085 FLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQE 1123 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.137 0.419 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,954,462 Number of Sequences: 37866 Number of extensions: 567600 Number of successful extensions: 1221 Number of sequences better than 10.0: 25 Number of HSP's better than 10.0 without gapping: 15 Number of HSP's successfully gapped in prelim test: 10 Number of HSP's that attempted gapping in prelim test: 1180 Number of HSP's gapped (non-prelim): 25 length of query: 326 length of database: 18,247,518 effective HSP length: 103 effective length of query: 223 effective length of database: 14,347,320 effective search space: 3199452360 effective search space used: 3199452360 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.