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Search of human proteins with 13384594
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13384594 protein kinase C, gamma [Homo sapiens]
(697 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13384594 protein kinase C, gamma [Homo sapiens] 1469 0.0
gi|4506067 protein kinase C, alpha [Homo sapiens] 1041 0.0
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 1006 0.0
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 979 0.0
gi|4885563 protein kinase C, epsilon [Homo sapiens] 409 e-114
gi|28557781 protein kinase C, eta [Homo sapiens] 384 e-106
gi|5453976 protein kinase C, theta [Homo sapiens] 363 e-100
gi|47157325 protein kinase C, delta [Homo sapiens] 362 e-100
gi|31377782 protein kinase C, delta [Homo sapiens] 362 e-100
gi|133908623 protein kinase C, iota [Homo sapiens] 350 3e-96
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 344 1e-94
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 344 1e-94
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 344 1e-94
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 319 5e-87
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 319 5e-87
gi|5453974 protein kinase N2 [Homo sapiens] 306 4e-83
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 305 1e-82
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 305 1e-82
gi|4502023 AKT2 kinase [Homo sapiens] 302 8e-82
gi|62241015 AKT1 kinase [Homo sapiens] 296 6e-80
gi|62241013 AKT1 kinase [Homo sapiens] 296 6e-80
gi|62241011 AKT1 kinase [Homo sapiens] 296 6e-80
gi|40254851 protein kinase PKNbeta [Homo sapiens] 291 1e-78
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 288 9e-78
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 288 9e-78
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 288 9e-78
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 288 9e-78
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 284 2e-76
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 282 6e-76
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 269 7e-72
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 1469 bits (3802), Expect = 0.0
Identities = 697/697 (100%), Positives = 697/697 (100%)
Query: 1 MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIG 60
MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIG
Sbjct: 1 MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIG 60
Query: 61 KQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSL 120
KQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSL
Sbjct: 61 KQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSL 120
Query: 121 LYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEA 180
LYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEA
Sbjct: 121 LYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEA 180
Query: 181 RNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRL 240
RNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRL
Sbjct: 181 RNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRL 240
Query: 241 SVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQ 300
SVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQ
Sbjct: 241 SVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQ 300
Query: 301 KFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKG 360
KFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKG
Sbjct: 301 KFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKG 360
Query: 361 SFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQL 420
SFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQL
Sbjct: 361 SFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQL 420
Query: 421 HSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRD 480
HSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRD
Sbjct: 421 HSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRD 480
Query: 481 LKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWS 540
LKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWS
Sbjct: 481 LKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWS 540
Query: 541 FGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGS 600
FGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGS
Sbjct: 541 FGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGS 600
Query: 601 GPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRL 660
GPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRL
Sbjct: 601 GPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRL 660
Query: 661 VLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM 697
VLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM
Sbjct: 661 VLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM 697
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 1041 bits (2691), Expect = 0.0
Identities = 487/673 (72%), Positives = 566/673 (84%), Gaps = 26/673 (3%)
Query: 19 FCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCH 78
F RKGALRQK VHEVK HKF ARFFKQPTFCSHCTDFIWG GKQG QCQVC FVVH+RCH
Sbjct: 20 FARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCH 79
Query: 79 EFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNV 138
EFVTF CPGA KGP TDDPR+KHKF++H+Y SPTFCDHCGSLLYGL+HQGMKC C+MNV
Sbjct: 80 EFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNV 139
Query: 139 HRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADE-IHVTVGEARNLIPMDPNGLSDPYVK 197
H++CV +VPSLCG+DHTE+RGR+ L +A ADE +HVTV +A+NLIPMDPNGLSDPYVK
Sbjct: 140 HKQCVINVPSLCGMDHTEKRGRIYL--KAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVK 197
Query: 198 LKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMG 257
LKLIPDP+N +KQKT+T+++TLNP WNE+F F LKP D +RRLSVE+WDWDRT+RNDFMG
Sbjct: 198 LKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMG 257
Query: 258 AMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADAD---NCSLLQKFEACNYPLELYER 314
++SFGVSEL+K P GWYKLLNQEEGEYYNVP+ + D N L QKFE +
Sbjct: 258 SLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFE----------K 307
Query: 315 VRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSD 374
++GP+ + + SPS P + R+ ++DF+FLMVLGKGSFGKVMLA+R+G++
Sbjct: 308 AKLGPAGNKVISPSEDRKQPSN-----NLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTE 362
Query: 375 ELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVM 434
ELYAIKILKKDV++QDDDV+CT+VEKRVLAL + P FLTQLHS FQT DRLYFVM
Sbjct: 363 ELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP-----FLTQLHSCFQTVDRLYFVM 417
Query: 435 EYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHI 494
EYV GGDLMYHIQQ+GKFKEP A FYAAEI+IGLFFLH +GIIYRDLKLDNVMLD+EGHI
Sbjct: 418 EYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHI 477
Query: 495 KITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPP 554
KI DFGMCKE++ G TTRTFCGTPDYIAPEIIAYQPYGKSVDWW++GVLLYEMLAGQPP
Sbjct: 478 KIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPP 537
Query: 555 FDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFF 614
FDGEDE+ELFQ+IME V+YPKSLS+EAV+ICKG +TKHP KRLG GP+GE +R H FF
Sbjct: 538 FDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFF 597
Query: 615 RWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFT 674
R IDWE+LE EI PPF+P+ CG+ ENFDKFFTR P LTPPD+LV+A+IDQ+DF+GF+
Sbjct: 598 RRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFS 657
Query: 675 YVNPDFVHPDARS 687
YVNP FVHP +S
Sbjct: 658 YVNPQFVHPILQS 670
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 1006 bits (2600), Expect = 0.0
Identities = 479/691 (69%), Positives = 566/691 (81%), Gaps = 22/691 (3%)
Query: 1 MAGLGPGVGDSEGGPRPL-FCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGI 59
MA G SEG + F RKGALRQK VHEVK+HKFTARFFKQPTFCSHCTDFIWG
Sbjct: 1 MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF 60
Query: 60 GKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGS 119
GKQG QCQVC FVVH+RCHEFVTF CPGA KGP +DDPR+KHKF++H+YSSPTFCDHCGS
Sbjct: 61 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS 120
Query: 120 LLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGE 179
LLYGL+HQGMKC C MNVH+RCV +VPSLCG DHTERRGR+ ++ D + V V +
Sbjct: 121 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDR-DVLIVLVRD 179
Query: 180 ARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERR 239
A+NL+PMDPNGLSDPYVKLKLIPDP++ +KQKT+T+K +LNP WNETF F LK D +RR
Sbjct: 180 AKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRR 239
Query: 240 LSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPV---ADADNC 296
LSVE+WDWD TSRNDFMG++SFG+SEL KA VDGW+KLL+QEEGEY+NVPV N
Sbjct: 240 LSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANE 299
Query: 297 SLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMV 356
L QKFE ++ G + +P + T K G + R+ ++DF+FLMV
Sbjct: 300 ELRQKFERA--------KISQG---TKVPEEKTTNTVSKFDNNG-NRDRMKLTDFNFLMV 347
Query: 357 LGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHF 416
LGKGSFGKVML+ER+G+DELYA+KILKKDV++QDDDV+CT+VEKRVLAL G+ P F
Sbjct: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP-----F 402
Query: 417 LTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGI 476
LTQLHS FQT DRLYFVMEYV GGDLMYHIQQ+G+FKEPHA FYAAEIAIGLFFL ++GI
Sbjct: 403 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGI 462
Query: 477 IYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSV 536
IYRDLKLDNVMLD+EGHIKI DFGMCKEN++ G TT+TFCGTPDYIAPEIIAYQPYGKSV
Sbjct: 463 IYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSV 522
Query: 537 DWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGK 596
DWW+FGVLLYEMLAGQ PF+GEDE+ELFQ+IME V YPKS+S+EAVAICKG +TKHPGK
Sbjct: 523 DWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGK 582
Query: 597 RLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTP 656
RLG GP+GE I+ H FFR+IDWE+LER EI PP++P+ CGR+ ENFD+FFTR P LTP
Sbjct: 583 RLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTP 642
Query: 657 PDRLVLASIDQADFQGFTYVNPDFVHPDARS 687
PD+ V+ +IDQ++F+GF++VN +F+ P+ +S
Sbjct: 643 PDQEVIRNIDQSEFEGFSFVNSEFLKPEVKS 673
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 979 bits (2530), Expect = 0.0
Identities = 473/686 (68%), Positives = 553/686 (80%), Gaps = 23/686 (3%)
Query: 1 MAGLGPGVGDSEGGPRPL-FCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGI 59
MA G SEG + F RKGALRQK VHEVK+HKFTARFFKQPTFCSHCTDFIWG
Sbjct: 1 MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF 60
Query: 60 GKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGS 119
GKQG QCQVC FVVH+RCHEFVTF CPGA KGP +DDPR+KHKF++H+YSSPTFCDHCGS
Sbjct: 61 GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS 120
Query: 120 LLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGE 179
LLYGL+HQGMKC C MNVH+RCV +VPSLCG DHTERRGR+ ++ D + V V +
Sbjct: 121 LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDR-DVLIVLVRD 179
Query: 180 ARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERR 239
A+NL+PMDPNGLSDPYVKLKLIPDP++ +KQKT+T+K +LNP WNETF F LK D +RR
Sbjct: 180 AKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRR 239
Query: 240 LSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPV---ADADNC 296
LSVE+WDWD TSRNDFMG++SFG+SEL KA VDGW+KLL+QEEGEY+NVPV N
Sbjct: 240 LSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANE 299
Query: 297 SLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMV 356
L QKFE ++ G + +P + T K G + R+ ++DF+FLMV
Sbjct: 300 ELRQKFERA--------KISQG---TKVPEEKTTNTVSKFDNNG-NRDRMKLTDFNFLMV 347
Query: 357 LGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHF 416
LGKGSFGKVML+ER+G+DELYA+KILKKDV++QDDDV+CT+VEKRVLAL G+ P F
Sbjct: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP-----F 402
Query: 417 LTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGI 476
LTQLHS FQT DRLYFVMEYV GGDLMYHIQQ+G+FKEPHA FYAAEIAIGLFFL ++GI
Sbjct: 403 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGI 462
Query: 477 IYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSV 536
IYRDLKLDNVMLD+EGHIKI DFGMCKEN++ G TT+TFCGTPDYIAPEIIAYQPYGKSV
Sbjct: 463 IYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSV 522
Query: 537 DWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGK 596
DWW+FGVLLYEMLAGQ PF+GEDE+ELFQ+IME V YPKS+S+EAVAICKG +TKHPGK
Sbjct: 523 DWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGK 582
Query: 597 RLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCG-RSGENFDKFFTRAAPALT 655
RLG GP+GE I+ H FFR+IDWE+LER EI PP++P+ R NFDK FTR LT
Sbjct: 583 RLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELT 642
Query: 656 PPDRLVLASIDQADFQGFTYVNPDFV 681
P D+L + ++DQ +F GF+Y NP+FV
Sbjct: 643 PTDKLFIMNLDQNEFAGFSYTNPEFV 668
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 409 bits (1051), Expect = e-114
Identities = 197/340 (57%), Positives = 252/340 (74%), Gaps = 8/340 (2%)
Query: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404
RL + +F+F+ VLGKGSFGKVMLAE +G DE+YA+K+LKKDVI+QDDDVDCT+ EKR+LA
Sbjct: 402 RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILA 461
Query: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464
L + P +LTQL+ FQT DRL+FVMEYV GGDLM+ IQ+ KF EP + FYAAE+
Sbjct: 462 LARKHP-----YLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEV 516
Query: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524
L FLH G+IYRDLKLDN++LDAEGH K+ DFGMCKE + G TT TFCGTPDYIAP
Sbjct: 517 TSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAP 576
Query: 525 EIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVA 584
EI+ YG SVDWW+ GVL+YEM+AGQPPF+ ++E++LF++I+ V YP LS+EAV+
Sbjct: 577 EILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVS 636
Query: 585 ICKGFLTKHPGKRLG--SGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPR-PCGRSGE 641
I K F+TK+P KRLG + +GE I+ H FF+ IDW LE+ +I PPF+PR R
Sbjct: 637 ILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVN 696
Query: 642 NFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFV 681
NFD+ FTR P LT D ++ I+Q +F+GF+Y D +
Sbjct: 697 NFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLM 736
Score = 173 bits (438), Expect = 6e-43
Identities = 79/141 (56%), Positives = 99/141 (70%), Gaps = 9/141 (6%)
Query: 21 RKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWG-IGKQGLQCQVCSFVVHRRCHE 79
R+GA+R++V H+V HKF A + +QPT+CSHC DFIWG IGKQG QCQVC+ VVH+RCHE
Sbjct: 156 RQGAVRRRV-HQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHE 214
Query: 80 FVTFECPGAGK-------GPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCS 132
+ +C G K G Q HKF +H+Y PTFCDHCGSLL+GL+ QG++C
Sbjct: 215 LIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCK 274
Query: 133 CCEMNVHRRCVRSVPSLCGVD 153
C+MNVHRRC +V CGVD
Sbjct: 275 VCKMNVHRRCETNVAPNCGVD 295
Score = 65.1 bits (157), Expect = 2e-10
Identities = 27/56 (48%), Positives = 33/56 (58%)
Query: 36 HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKG 91
HKF +K PTFC HC +WG+ +QGLQC+VC VHRRC V C +G
Sbjct: 243 HKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARG 298
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 384 bits (986), Expect = e-106
Identities = 194/340 (57%), Positives = 238/340 (70%), Gaps = 7/340 (2%)
Query: 342 SPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKR 401
S RL I +F F+ VLGKGSFGKVMLA + + +LYA+K+LKKDVI+QDDDV+CT+ EKR
Sbjct: 346 SSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKR 405
Query: 402 VLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYA 461
+L+L P FLTQL FQTPDRL+FVME+V GGDLM+HIQ+ +F E A FYA
Sbjct: 406 ILSLARNHP-----FLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYA 460
Query: 462 AEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDY 521
AEI L FLH++GIIYRDLKLDNV+LD EGH K+ DFGMCKE + G TT TFCGTPDY
Sbjct: 461 AEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDY 520
Query: 522 IAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSRE 581
IAPEI+ YG +VDWW+ GVLLYEML G PF+ E+E++LF+AI+ V YP L +
Sbjct: 521 IAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHED 580
Query: 582 AVAICKGFLTKHPGKRLGS-GPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSG 640
A I K F+TK+P RLGS GE I H FF+ IDW +L +I PPFRPR R
Sbjct: 581 ATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSRED 640
Query: 641 -ENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPD 679
NFD F + P LTP D L I+Q +F+ F+YV+P+
Sbjct: 641 VSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE 680
Score = 154 bits (390), Expect = 2e-37
Identities = 69/145 (47%), Positives = 95/145 (65%), Gaps = 10/145 (6%)
Query: 21 RKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGI-GKQGLQCQVCSFVVHRRCHE 79
R+ A+R++V H++ HKF A + +QPT+CSHC +FIWG+ GKQG QCQVC+ VVH+RCH
Sbjct: 158 RQRAMRRRV-HQINGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHH 216
Query: 80 FVTFECPGAGKGPQTDDPRNK--------HKFRLHSYSSPTFCDHCGSLLYGLVHQGMKC 131
+ C + D + HKF +H+Y PTFCDHCGSLL+G++ QG++C
Sbjct: 217 LIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQC 276
Query: 132 SCCEMNVHRRCVRSVPSLCGVDHTE 156
C+MNVH RC +V CGV+ E
Sbjct: 277 KICKMNVHIRCQANVAPNCGVNAVE 301
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 363 bits (931), Expect = e-100
Identities = 187/335 (55%), Positives = 228/335 (68%), Gaps = 10/335 (2%)
Query: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404
+L I DF +LGKGSFGKV LAE + +++ +AIK LKKDV++ DDDV+CT+VEKRVL+
Sbjct: 374 KLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 433
Query: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464
L P FLT + TFQT + L+FVMEY+ GGDLMYHIQ KF A FYAAEI
Sbjct: 434 LAWEHP-----FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEI 488
Query: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524
+GL FLH++GI+YRDLKLDN++LD +GHIKI DFGMCKEN+ T TFCGTPDYIAP
Sbjct: 489 ILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAP 548
Query: 525 EIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVA 584
EI+ Q Y SVDWWSFGVLLYEML GQ PF G+DEEELF +I YP+ L +EA
Sbjct: 549 EILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKD 608
Query: 585 ICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPR-PCGRSGENF 643
+ + P KRLG D IR H FR I+WE LER EI PPFRP+ NF
Sbjct: 609 LLVKLFVREPEKRLGVRGD----IRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNF 664
Query: 644 DKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNP 678
DK F P L+ DR ++ S+DQ F+ F+++NP
Sbjct: 665 DKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNP 699
Score = 155 bits (393), Expect = 9e-38
Identities = 66/140 (47%), Positives = 96/140 (68%), Gaps = 7/140 (5%)
Query: 21 RKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEF 80
R+GA++Q VH VK H+FTA FF QPTFCS C +F+WG+ KQG QC+ C+ +H++C +
Sbjct: 145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDK 204
Query: 81 VTFECPGAG-KGPQTDDPRNK------HKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSC 133
V +C G+ +T + + H+F++++Y SPTFC+HCG+LL+GL QG+KC
Sbjct: 205 VIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDA 264
Query: 134 CEMNVHRRCVRSVPSLCGVD 153
C MNVH RC V +LCG++
Sbjct: 265 CGMNVHHRCQTKVANLCGIN 284
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 362 bits (928), Expect = e-100
Identities = 185/339 (54%), Positives = 234/339 (69%), Gaps = 10/339 (2%)
Query: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404
+ +I++F F VLGKGSFGKV+L E +G E +AIK LKKDV++ DDDV+CT+VEKRVL
Sbjct: 343 KCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLT 402
Query: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464
L P FLT L TFQT D L+FVME++ GGDLMYHIQ G+F+ A FYAAEI
Sbjct: 403 LAAENP-----FLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEI 457
Query: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524
GL FLH++GIIYRDLKLDNV+LD +GHIKI DFGMCKEN+F + TFCGTPDYIAP
Sbjct: 458 MCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAP 517
Query: 525 EIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVA 584
EI+ Y SVDWWSFGVLLYEML GQ PF G+DE+ELF++I T YP+ +++E+
Sbjct: 518 EILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKD 577
Query: 585 ICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPR-PCGRSGENF 643
I + + P KRLG I+ H FF+ I+W LE+ + PPFRP+ R NF
Sbjct: 578 ILEKLFEREPTKRLGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNF 633
Query: 644 DKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVH 682
D+ F L+ D+ ++ S+DQ+ F GF++VNP F H
Sbjct: 634 DQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEH 672
Score = 157 bits (396), Expect = 4e-38
Identities = 67/144 (46%), Positives = 96/144 (66%), Gaps = 7/144 (4%)
Query: 17 PLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRR 76
P R+GA++Q +H +K+H+F A FF QPTFCS C DF+WG+ KQG +C+ C+ +H++
Sbjct: 140 PTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKK 199
Query: 77 CHEFVTFECPG-AGKGPQTDDPRNK------HKFRLHSYSSPTFCDHCGSLLYGLVHQGM 129
C + + C G A T + + H+F++H+Y SPTFCDHCGSLL+GLV QG+
Sbjct: 200 CIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGL 259
Query: 130 KCSCCEMNVHRRCVRSVPSLCGVD 153
KC C MNVH +C V +LCG++
Sbjct: 260 KCEDCGMNVHHKCREKVANLCGIN 283
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 362 bits (928), Expect = e-100
Identities = 185/339 (54%), Positives = 234/339 (69%), Gaps = 10/339 (2%)
Query: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404
+ +I++F F VLGKGSFGKV+L E +G E +AIK LKKDV++ DDDV+CT+VEKRVL
Sbjct: 343 KCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLT 402
Query: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464
L P FLT L TFQT D L+FVME++ GGDLMYHIQ G+F+ A FYAAEI
Sbjct: 403 LAAENP-----FLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEI 457
Query: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524
GL FLH++GIIYRDLKLDNV+LD +GHIKI DFGMCKEN+F + TFCGTPDYIAP
Sbjct: 458 MCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAP 517
Query: 525 EIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVA 584
EI+ Y SVDWWSFGVLLYEML GQ PF G+DE+ELF++I T YP+ +++E+
Sbjct: 518 EILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKD 577
Query: 585 ICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPR-PCGRSGENF 643
I + + P KRLG I+ H FF+ I+W LE+ + PPFRP+ R NF
Sbjct: 578 ILEKLFEREPTKRLGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNF 633
Query: 644 DKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVH 682
D+ F L+ D+ ++ S+DQ+ F GF++VNP F H
Sbjct: 634 DQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEH 672
Score = 157 bits (396), Expect = 4e-38
Identities = 67/144 (46%), Positives = 96/144 (66%), Gaps = 7/144 (4%)
Query: 17 PLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRR 76
P R+GA++Q +H +K+H+F A FF QPTFCS C DF+WG+ KQG +C+ C+ +H++
Sbjct: 140 PTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKK 199
Query: 77 CHEFVTFECPG-AGKGPQTDDPRNK------HKFRLHSYSSPTFCDHCGSLLYGLVHQGM 129
C + + C G A T + + H+F++H+Y SPTFCDHCGSLL+GLV QG+
Sbjct: 200 CIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGL 259
Query: 130 KCSCCEMNVHRRCVRSVPSLCGVD 153
KC C MNVH +C V +LCG++
Sbjct: 260 KCEDCGMNVHHKCREKVANLCGIN 283
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 350 bits (898), Expect = 3e-96
Identities = 171/350 (48%), Positives = 235/350 (67%), Gaps = 16/350 (4%)
Query: 340 GASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVE 399
G + L + DF L V+G+GS+ KV+L + +D +YA+K++KK+++ D+D+D E
Sbjct: 243 GKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTE 302
Query: 400 KRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAF 459
K V P FL LHS FQT RL+FV+EYV GGDLM+H+Q+ K E HA F
Sbjct: 303 KHVFEQASNHP-----FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARF 357
Query: 460 YAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTP 519
Y+AEI++ L +LH +GIIYRDLKLDNV+LD+EGHIK+TD+GMCKE + PG TT TFCGTP
Sbjct: 358 YSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTP 417
Query: 520 DYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPF---------DGEDEEELFQAIMEQ 570
+YIAPEI+ + YG SVDWW+ GVL++EM+AG+ PF D E+ LFQ I+E+
Sbjct: 418 NYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEK 477
Query: 571 TVTYPKSLSREAVAICKGFLTKHPGKRLGSGPD-GEPTIRAHGFFRWIDWERLERLEIPP 629
+ P+SLS +A ++ K FL K P +RLG P G I+ H FFR +DW+ +E+ ++ P
Sbjct: 478 QIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVP 537
Query: 630 PFRPRPCGRSG-ENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNP 678
PF+P G G +NFD FT LTP D ++ IDQ++F+GF Y+NP
Sbjct: 538 PFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 587
Score = 71.2 bits (173), Expect = 3e-12
Identities = 33/84 (39%), Positives = 48/84 (57%), Gaps = 4/84 (4%)
Query: 6 PGVGDSEGGPRP----LFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGK 61
P V + G P P R+GA R + ++ H F A+ F + C+ CTD IWG+G+
Sbjct: 107 PCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGR 166
Query: 62 QGLQCQVCSFVVHRRCHEFVTFEC 85
QG +C C +VH++CH+ VT EC
Sbjct: 167 QGYKCINCKLLVHKKCHKLVTIEC 190
Score = 44.7 bits (104), Expect = 3e-04
Identities = 32/113 (28%), Positives = 48/113 (42%), Gaps = 15/113 (13%)
Query: 85 CPGAGKGPQTDDPR--------NKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEM 136
CPG K R N H F+ ++ C C ++GL QG KC C++
Sbjct: 117 CPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKL 176
Query: 137 NVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPN 189
VH++C + V CG R L E P D+ + A+ +IP +P+
Sbjct: 177 LVHKKCHKLVTIECG------RHSLPQEPVMP-MDQSSMHSDHAQTVIPYNPS 222
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 344 bits (883), Expect = 1e-94
Identities = 172/342 (50%), Positives = 230/342 (67%), Gaps = 14/342 (4%)
Query: 346 LHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLAL 405
L + DF + V+G+GS+ KV+L + +D++YA+K++KK+++ D+D+D EK V
Sbjct: 64 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123
Query: 406 GGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIA 465
P FL LHS FQT RL+ V+EYV GGDLM+H+Q+ K E HA FYAAEI
Sbjct: 124 ASSNP-----FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEIC 178
Query: 466 IGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPE 525
I L FLH +GIIYRDLKLDNV+LDA+GHIK+TD+GMCKE + PG TT TFCGTP+YIAPE
Sbjct: 179 IALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPE 238
Query: 526 IIAYQPYGKSVDWWSFGVLLYEMLAGQPPF-------DGEDEEELFQAIMEQTVTYPKSL 578
I+ + YG SVDWW+ GVL++EM+AG+ PF D E+ LFQ I+E+ + P+ L
Sbjct: 239 ILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFL 298
Query: 579 SREAVAICKGFLTKHPGKRLGSGPD-GEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCG 637
S +A + KGFL K P +RLG P G I++H FFR IDW+ LE+ + PPF+P+
Sbjct: 299 SVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITD 358
Query: 638 RSG-ENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNP 678
G +NFD FT LTP D + IDQ++F+GF Y+NP
Sbjct: 359 DYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 344 bits (883), Expect = 1e-94
Identities = 172/342 (50%), Positives = 230/342 (67%), Gaps = 14/342 (4%)
Query: 346 LHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLAL 405
L + DF + V+G+GS+ KV+L + +D++YA+K++KK+++ D+D+D EK V
Sbjct: 64 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123
Query: 406 GGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIA 465
P FL LHS FQT RL+ V+EYV GGDLM+H+Q+ K E HA FYAAEI
Sbjct: 124 ASSNP-----FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEIC 178
Query: 466 IGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPE 525
I L FLH +GIIYRDLKLDNV+LDA+GHIK+TD+GMCKE + PG TT TFCGTP+YIAPE
Sbjct: 179 IALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPE 238
Query: 526 IIAYQPYGKSVDWWSFGVLLYEMLAGQPPF-------DGEDEEELFQAIMEQTVTYPKSL 578
I+ + YG SVDWW+ GVL++EM+AG+ PF D E+ LFQ I+E+ + P+ L
Sbjct: 239 ILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFL 298
Query: 579 SREAVAICKGFLTKHPGKRLGSGPD-GEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCG 637
S +A + KGFL K P +RLG P G I++H FFR IDW+ LE+ + PPF+P+
Sbjct: 299 SVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITD 358
Query: 638 RSG-ENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNP 678
G +NFD FT LTP D + IDQ++F+GF Y+NP
Sbjct: 359 DYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 344 bits (883), Expect = 1e-94
Identities = 172/342 (50%), Positives = 230/342 (67%), Gaps = 14/342 (4%)
Query: 346 LHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLAL 405
L + DF + V+G+GS+ KV+L + +D++YA+K++KK+++ D+D+D EK V
Sbjct: 247 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 306
Query: 406 GGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIA 465
P FL LHS FQT RL+ V+EYV GGDLM+H+Q+ K E HA FYAAEI
Sbjct: 307 ASSNP-----FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEIC 361
Query: 466 IGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPE 525
I L FLH +GIIYRDLKLDNV+LDA+GHIK+TD+GMCKE + PG TT TFCGTP+YIAPE
Sbjct: 362 IALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPE 421
Query: 526 IIAYQPYGKSVDWWSFGVLLYEMLAGQPPF-------DGEDEEELFQAIMEQTVTYPKSL 578
I+ + YG SVDWW+ GVL++EM+AG+ PF D E+ LFQ I+E+ + P+ L
Sbjct: 422 ILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFL 481
Query: 579 SREAVAICKGFLTKHPGKRLGSGPD-GEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCG 637
S +A + KGFL K P +RLG P G I++H FFR IDW+ LE+ + PPF+P+
Sbjct: 482 SVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITD 541
Query: 638 RSG-ENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNP 678
G +NFD FT LTP D + IDQ++F+GF Y+NP
Sbjct: 542 DYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 583
Score = 64.3 bits (155), Expect = 4e-10
Identities = 24/65 (36%), Positives = 38/65 (58%)
Query: 21 RKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEF 80
R+GA R + ++ H F A+ F + +C C++ IWG+ +QG +C C +VH+RCH
Sbjct: 116 RRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGL 175
Query: 81 VTFEC 85
V C
Sbjct: 176 VPLTC 180
Score = 47.8 bits (112), Expect = 4e-05
Identities = 23/74 (31%), Positives = 33/74 (44%), Gaps = 8/74 (10%)
Query: 85 CPGAGKGPQTDDPR--------NKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEM 136
CPG K R N H F+ ++ +C C ++GL QG +C C++
Sbjct: 107 CPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKL 166
Query: 137 NVHRRCVRSVPSLC 150
VH+RC VP C
Sbjct: 167 LVHKRCHGLVPLTC 180
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 319 bits (818), Expect = 5e-87
Identities = 175/363 (48%), Positives = 228/363 (62%), Gaps = 14/363 (3%)
Query: 320 SSSP-IPSPSPSPTDPKRCFFGASPGR---LHISDFSFLMVLGKGSFGKVMLAERRGSDE 375
S++P +PS + P C SP R L + DF FL VLG+G FGKV+L+E R S E
Sbjct: 590 STAPELPSETQETPGPALC----SPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGE 645
Query: 376 LYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVME 435
L+AIK LKK IV D+V+ + EKR+LA G P FL L FQTP+ + FVME
Sbjct: 646 LFAIKALKKGDIVARDEVESLMCEKRILA--AVTSAGHP-FLVNLFGCFQTPEHVCFVME 702
Query: 436 YVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIK 495
Y GGDLM HI F EP A FY+A + +GL FLH I+YRDLKLDN++LD EG++K
Sbjct: 703 YSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVK 761
Query: 496 ITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPF 555
I DFG+CKE + G T TFCGTP+++APE++ Y ++VDWW GVLLYEML G+ PF
Sbjct: 762 IADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPF 821
Query: 556 DGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFR 615
G+DEEE+F +I+ V YP+ LS EA+ I + L ++P +RLGS ++ FFR
Sbjct: 822 PGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFR 881
Query: 616 WIDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRAAPALTPP-DRLVLASIDQADFQGF 673
+ WE L +PPPF P GR+ NFD+ FT AP L+PP D L + +QA F F
Sbjct: 882 TLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDF 941
Query: 674 TYV 676
+V
Sbjct: 942 DFV 944
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 319 bits (818), Expect = 5e-87
Identities = 175/363 (48%), Positives = 228/363 (62%), Gaps = 14/363 (3%)
Query: 320 SSSP-IPSPSPSPTDPKRCFFGASPGR---LHISDFSFLMVLGKGSFGKVMLAERRGSDE 375
S++P +PS + P C SP R L + DF FL VLG+G FGKV+L+E R S E
Sbjct: 584 STAPELPSETQETPGPALC----SPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGE 639
Query: 376 LYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVME 435
L+AIK LKK IV D+V+ + EKR+LA G P FL L FQTP+ + FVME
Sbjct: 640 LFAIKALKKGDIVARDEVESLMCEKRILA--AVTSAGHP-FLVNLFGCFQTPEHVCFVME 696
Query: 436 YVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIK 495
Y GGDLM HI F EP A FY+A + +GL FLH I+YRDLKLDN++LD EG++K
Sbjct: 697 YSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVK 755
Query: 496 ITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPF 555
I DFG+CKE + G T TFCGTP+++APE++ Y ++VDWW GVLLYEML G+ PF
Sbjct: 756 IADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPF 815
Query: 556 DGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFR 615
G+DEEE+F +I+ V YP+ LS EA+ I + L ++P +RLGS ++ FFR
Sbjct: 816 PGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFR 875
Query: 616 WIDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRAAPALTPP-DRLVLASIDQADFQGF 673
+ WE L +PPPF P GR+ NFD+ FT AP L+PP D L + +QA F F
Sbjct: 876 TLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDF 935
Query: 674 TYV 676
+V
Sbjct: 936 DFV 938
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 306 bits (784), Expect = 4e-83
Identities = 156/334 (46%), Positives = 212/334 (63%), Gaps = 6/334 (1%)
Query: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404
+ ++ DF VLG+G FGKV+LAE + ++E++AIK LKK IV D+VD + EKR+
Sbjct: 651 QFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFE 710
Query: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464
R FL L + FQT + + FVMEY GGDLM HI F EP A FYAA +
Sbjct: 711 TVN---SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPRAVFYAACV 766
Query: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524
+GL +LH I+YRDLKLDN++LD EG +KI DFG+CKE + G T TFCGTP+++AP
Sbjct: 767 VLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 826
Query: 525 EIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVA 584
E++ Y ++VDWW GVL+YEML G+ PF G+DEEE+F +I+ V YP+ LS EA++
Sbjct: 827 EVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAIS 886
Query: 585 ICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSG-ENF 643
I + L ++P +RLG+ ++ H FFR IDW L ++ PPF P GR NF
Sbjct: 887 IMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNF 946
Query: 644 DKFFTRAAPALTPP-DRLVLASIDQADFQGFTYV 676
D FT AP LTPP + +L+ +Q F+ F Y+
Sbjct: 947 DDEFTSEAPILTPPREPRILSEEEQEMFRDFDYI 980
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 305 bits (780), Expect = 1e-82
Identities = 146/316 (46%), Positives = 207/316 (65%), Gaps = 7/316 (2%)
Query: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404
R ++DF +L +LGKG+FGKV+L + S + YA+KILKK+VI+ D+V TL E RVL
Sbjct: 142 RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK 201
Query: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464
R FLT L +FQT DRL FVMEYV GG+L +H+ + F E FY AEI
Sbjct: 202 ------NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEI 255
Query: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524
L +LH+ I+YRDLKL+N+MLD +GHIKITDFG+CKE + T +TFCGTP+Y+AP
Sbjct: 256 VSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAP 315
Query: 525 EIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVA 584
E++ YG++VDWW GV++YEM+ G+ PF +D E+LF+ I+ + + +P++LS +A +
Sbjct: 316 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKS 375
Query: 585 ICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGEN-F 643
+ G L K P KRLG GPD I H FF ++W+ + ++ PPF+P+ + F
Sbjct: 376 LLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435
Query: 644 DKFFTRAAPALTPPDR 659
D+ FT +TPP++
Sbjct: 436 DEEFTAQTITITPPEK 451
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 305 bits (780), Expect = 1e-82
Identities = 146/316 (46%), Positives = 207/316 (65%), Gaps = 7/316 (2%)
Query: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404
R ++DF +L +LGKG+FGKV+L + S + YA+KILKK+VI+ D+V TL E RVL
Sbjct: 142 RKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK 201
Query: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464
R FLT L +FQT DRL FVMEYV GG+L +H+ + F E FY AEI
Sbjct: 202 ------NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEI 255
Query: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524
L +LH+ I+YRDLKL+N+MLD +GHIKITDFG+CKE + T +TFCGTP+Y+AP
Sbjct: 256 VSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAP 315
Query: 525 EIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVA 584
E++ YG++VDWW GV++YEM+ G+ PF +D E+LF+ I+ + + +P++LS +A +
Sbjct: 316 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKS 375
Query: 585 ICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGEN-F 643
+ G L K P KRLG GPD I H FF ++W+ + ++ PPF+P+ + F
Sbjct: 376 LLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435
Query: 644 DKFFTRAAPALTPPDR 659
D+ FT +TPP++
Sbjct: 436 DEEFTAQTITITPPEK 451
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 302 bits (773), Expect = 8e-82
Identities = 154/356 (43%), Positives = 222/356 (62%), Gaps = 12/356 (3%)
Query: 326 SPSPSPT-DPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKK 384
SPS S T + + ++ ++DF +L +LGKG+FGKV+L + + YA+KIL+K
Sbjct: 126 SPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRK 185
Query: 385 DVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMY 444
+VI+ D+V T+ E RVL R FLT L FQT DRL FVMEY GG+L +
Sbjct: 186 EVIIAKDEVAHTVTESRVLQ------NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFF 239
Query: 445 HIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKE 504
H+ + F E A FY AEI L +LH++ ++YRD+KL+N+MLD +GHIKITDFG+CKE
Sbjct: 240 HLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKE 299
Query: 505 NVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELF 564
+ G T +TFCGTP+Y+APE++ YG++VDWW GV++YEM+ G+ PF +D E LF
Sbjct: 300 GISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF 359
Query: 565 QAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLER 624
+ I+ + + +P++LS EA ++ G L K P +RLG GP + H FF I+W+ + +
Sbjct: 360 ELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQ 419
Query: 625 LEIPPPFRPRPCGR-SGENFDKFFTRAAPALTPPDR---LVLASIDQ-ADFQGFTY 675
++ PPF+P+ FD FT + +TPPDR L L +DQ F F+Y
Sbjct: 420 KKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 296 bits (757), Expect = 6e-80
Identities = 144/317 (45%), Positives = 207/317 (65%), Gaps = 8/317 (2%)
Query: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404
R+ +++F +L +LGKG+FGKV+L + + + YA+KILKK+VIV D+V TL E RVL
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203
Query: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464
R FLT L +FQT DRL FVMEY GG+L +H+ + F E A FY AEI
Sbjct: 204 ------NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 257
Query: 465 AIGLFFLHNQ-GIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIA 523
L +LH++ ++YRDLKL+N+MLD +GHIKITDFG+CKE + G T +TFCGTP+Y+A
Sbjct: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317
Query: 524 PEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAV 583
PE++ YG++VDWW GV++YEM+ G+ PF +D E+LF+ I+ + + +P++L EA
Sbjct: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAK 377
Query: 584 AICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGEN- 642
++ G L K P +RLG G + I H FF I W+ + ++ PPF+P+ +
Sbjct: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
Query: 643 FDKFFTRAAPALTPPDR 659
FD+ FT +TPPD+
Sbjct: 438 FDEEFTAQMITITPPDQ 454
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 296 bits (757), Expect = 6e-80
Identities = 144/317 (45%), Positives = 207/317 (65%), Gaps = 8/317 (2%)
Query: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404
R+ +++F +L +LGKG+FGKV+L + + + YA+KILKK+VIV D+V TL E RVL
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203
Query: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464
R FLT L +FQT DRL FVMEY GG+L +H+ + F E A FY AEI
Sbjct: 204 ------NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 257
Query: 465 AIGLFFLHNQ-GIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIA 523
L +LH++ ++YRDLKL+N+MLD +GHIKITDFG+CKE + G T +TFCGTP+Y+A
Sbjct: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317
Query: 524 PEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAV 583
PE++ YG++VDWW GV++YEM+ G+ PF +D E+LF+ I+ + + +P++L EA
Sbjct: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAK 377
Query: 584 AICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGEN- 642
++ G L K P +RLG G + I H FF I W+ + ++ PPF+P+ +
Sbjct: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
Query: 643 FDKFFTRAAPALTPPDR 659
FD+ FT +TPPD+
Sbjct: 438 FDEEFTAQMITITPPDQ 454
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 296 bits (757), Expect = 6e-80
Identities = 144/317 (45%), Positives = 207/317 (65%), Gaps = 8/317 (2%)
Query: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404
R+ +++F +L +LGKG+FGKV+L + + + YA+KILKK+VIV D+V TL E RVL
Sbjct: 144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 203
Query: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464
R FLT L +FQT DRL FVMEY GG+L +H+ + F E A FY AEI
Sbjct: 204 ------NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 257
Query: 465 AIGLFFLHNQ-GIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIA 523
L +LH++ ++YRDLKL+N+MLD +GHIKITDFG+CKE + G T +TFCGTP+Y+A
Sbjct: 258 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 317
Query: 524 PEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAV 583
PE++ YG++VDWW GV++YEM+ G+ PF +D E+LF+ I+ + + +P++L EA
Sbjct: 318 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAK 377
Query: 584 AICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGEN- 642
++ G L K P +RLG G + I H FF I W+ + ++ PPF+P+ +
Sbjct: 378 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
Query: 643 FDKFFTRAAPALTPPDR 659
FD+ FT +TPPD+
Sbjct: 438 FDEEFTAQMITITPPDQ 454
>gi|40254851 protein kinase PKNbeta [Homo sapiens]
Length = 889
Score = 291 bits (746), Expect = 1e-78
Identities = 165/373 (44%), Positives = 218/373 (58%), Gaps = 16/373 (4%)
Query: 313 ERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRG 372
+R M P + PSP SPT P RL DF L VLG+G FGKV+L + +G
Sbjct: 531 KRPHMEPRTRRGPSPPASPT--------RKPPRLQ--DFRCLAVLGRGHFGKVLLVQFKG 580
Query: 373 SDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYF 432
+ + YAIK LKK ++ D+++ EKR+L G G P FL L + FQT F
Sbjct: 581 TGKYYAIKALKKQEVLSRDEIESLYCEKRILE--AVGCTGHP-FLLSLLACFQTSSHACF 637
Query: 433 VMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEG 492
V E+V GGDLM I + F EP A FY A + +GL FLH + IIYRDLKLDN++LDA+G
Sbjct: 638 VTEFVPGGDLMMQIHE-DVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQG 696
Query: 493 HIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQ 552
+KI DFG+CKE + G T TFCGTP+++APE++ + Y ++VDWW GVLLYEML G+
Sbjct: 697 FLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGE 756
Query: 553 PPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHG 612
PF G+ EEE+F I+ YP LS + + + L K P KRLG+G I+
Sbjct: 757 CPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQP 816
Query: 613 FFRWIDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRAAPALTPP-DRLVLASIDQADF 670
FFR +W+ L I PPF P CG + F+ FT PALTPP +L + QA F
Sbjct: 817 FFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAF 876
Query: 671 QGFTYVNPDFVHP 683
+ F +V+ F+ P
Sbjct: 877 RDFDFVSERFLEP 889
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 288 bits (738), Expect = 9e-78
Identities = 159/387 (41%), Positives = 231/387 (59%), Gaps = 20/387 (5%)
Query: 304 ACNYPLELYERVRMGPSSSPI-----PSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLG 358
AC +P E+ +++ P PSP PSP+ ++P SDF FL V+G
Sbjct: 48 ACKHP-EVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNP-HAKPSDFHFLKVIG 105
Query: 359 KGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLT 418
KGSFGKV+LA + + YA+K+L+K I++ + + E+ VL + P FL
Sbjct: 106 KGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP-----FLV 160
Query: 419 QLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIY 478
LH +FQT D+LYFV++Y+ GG+L YH+Q+ F EP A FYAAEIA L +LH+ I+Y
Sbjct: 161 GLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVY 220
Query: 479 RDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDW 538
RDLK +N++LD++GHI +TDFG+CKEN+ +TT TFCGTP+Y+APE++ QPY ++VDW
Sbjct: 221 RDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDW 280
Query: 539 WSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRL 598
W G +LYEML G PPF + E++ I+ + + +++ A + +G L K KRL
Sbjct: 281 WCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL 340
Query: 599 GSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRA----APA 653
G+ D I++H FF I+W+ L +I PPF P G + +FD FT +
Sbjct: 341 GA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIG 399
Query: 654 LTPPDRLVLASIDQA--DFQGFTYVNP 678
+P LV AS+ +A F GF+Y P
Sbjct: 400 KSPDSVLVTASVKEAAEAFLGFSYAPP 426
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 288 bits (738), Expect = 9e-78
Identities = 159/387 (41%), Positives = 231/387 (59%), Gaps = 20/387 (5%)
Query: 304 ACNYPLELYERVRMGPSSSPI-----PSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLG 358
AC +P E+ +++ P PSP PSP+ ++P SDF FL V+G
Sbjct: 62 ACKHP-EVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNP-HAKPSDFHFLKVIG 119
Query: 359 KGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLT 418
KGSFGKV+LA + + YA+K+L+K I++ + + E+ VL + P FL
Sbjct: 120 KGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP-----FLV 174
Query: 419 QLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIY 478
LH +FQT D+LYFV++Y+ GG+L YH+Q+ F EP A FYAAEIA L +LH+ I+Y
Sbjct: 175 GLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVY 234
Query: 479 RDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDW 538
RDLK +N++LD++GHI +TDFG+CKEN+ +TT TFCGTP+Y+APE++ QPY ++VDW
Sbjct: 235 RDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDW 294
Query: 539 WSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRL 598
W G +LYEML G PPF + E++ I+ + + +++ A + +G L K KRL
Sbjct: 295 WCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL 354
Query: 599 GSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRA----APA 653
G+ D I++H FF I+W+ L +I PPF P G + +FD FT +
Sbjct: 355 GA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIG 413
Query: 654 LTPPDRLVLASIDQA--DFQGFTYVNP 678
+P LV AS+ +A F GF+Y P
Sbjct: 414 KSPDSVLVTASVKEAAEAFLGFSYAPP 440
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 288 bits (738), Expect = 9e-78
Identities = 159/387 (41%), Positives = 231/387 (59%), Gaps = 20/387 (5%)
Query: 304 ACNYPLELYERVRMGPSSSPI-----PSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLG 358
AC +P E+ +++ P PSP PSP+ ++P SDF FL V+G
Sbjct: 76 ACKHP-EVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNP-HAKPSDFHFLKVIG 133
Query: 359 KGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLT 418
KGSFGKV+LA + + YA+K+L+K I++ + + E+ VL + P FL
Sbjct: 134 KGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP-----FLV 188
Query: 419 QLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIY 478
LH +FQT D+LYFV++Y+ GG+L YH+Q+ F EP A FYAAEIA L +LH+ I+Y
Sbjct: 189 GLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVY 248
Query: 479 RDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDW 538
RDLK +N++LD++GHI +TDFG+CKEN+ +TT TFCGTP+Y+APE++ QPY ++VDW
Sbjct: 249 RDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDW 308
Query: 539 WSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRL 598
W G +LYEML G PPF + E++ I+ + + +++ A + +G L K KRL
Sbjct: 309 WCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL 368
Query: 599 GSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRA----APA 653
G+ D I++H FF I+W+ L +I PPF P G + +FD FT +
Sbjct: 369 GA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIG 427
Query: 654 LTPPDRLVLASIDQA--DFQGFTYVNP 678
+P LV AS+ +A F GF+Y P
Sbjct: 428 KSPDSVLVTASVKEAAEAFLGFSYAPP 454
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 288 bits (738), Expect = 9e-78
Identities = 159/387 (41%), Positives = 231/387 (59%), Gaps = 20/387 (5%)
Query: 304 ACNYPLELYERVRMGPSSSPI-----PSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLG 358
AC +P E+ +++ P PSP PSP+ ++P SDF FL V+G
Sbjct: 143 ACKHP-EVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNP-HAKPSDFHFLKVIG 200
Query: 359 KGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLT 418
KGSFGKV+LA + + YA+K+L+K I++ + + E+ VL + P FL
Sbjct: 201 KGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP-----FLV 255
Query: 419 QLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIY 478
LH +FQT D+LYFV++Y+ GG+L YH+Q+ F EP A FYAAEIA L +LH+ I+Y
Sbjct: 256 GLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVY 315
Query: 479 RDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDW 538
RDLK +N++LD++GHI +TDFG+CKEN+ +TT TFCGTP+Y+APE++ QPY ++VDW
Sbjct: 316 RDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDW 375
Query: 539 WSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRL 598
W G +LYEML G PPF + E++ I+ + + +++ A + +G L K KRL
Sbjct: 376 WCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL 435
Query: 599 GSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRA----APA 653
G+ D I++H FF I+W+ L +I PPF P G + +FD FT +
Sbjct: 436 GA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIG 494
Query: 654 LTPPDRLVLASIDQA--DFQGFTYVNP 678
+P LV AS+ +A F GF+Y P
Sbjct: 495 KSPDSVLVTASVKEAAEAFLGFSYAPP 521
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 284 bits (727), Expect = 2e-76
Identities = 149/368 (40%), Positives = 222/368 (60%), Gaps = 10/368 (2%)
Query: 316 RMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDE 375
RM S + PSP PS + ++ +DF FL V+GKG++GKV+LA+R+
Sbjct: 60 RMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGA 119
Query: 376 LYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVME 435
YA+K+L+K I++ + + E+ VL R P FL L +FQTP++LYFV++
Sbjct: 120 FYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP-----FLVGLRYSFQTPEKLYFVLD 174
Query: 436 YVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIK 495
YV GG+L +H+Q+ +F EP A FYAAE+A + +LH+ IIYRDLK +N++LD +GH+
Sbjct: 175 YVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVV 234
Query: 496 ITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPF 555
+TDFG+CKE V P TT TFCGTP+Y+APE++ +PY ++VDWW G +LYEML G PPF
Sbjct: 235 LTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPF 294
Query: 556 DGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFR 615
+D ++++ I+ Q + P + A + + L K +RLGS D I+ H FF
Sbjct: 295 YSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKAD-FLEIKNHVFFS 353
Query: 616 WIDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRAAPALT---PPDRLVLASIDQADFQ 671
I+W+ L + PPF P G + ++FD FT+ A + + PD + +S + F
Sbjct: 354 PINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFL 413
Query: 672 GFTYVNPD 679
GF+Y D
Sbjct: 414 GFSYAPED 421
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 282 bits (722), Expect = 6e-76
Identities = 148/367 (40%), Positives = 221/367 (60%), Gaps = 10/367 (2%)
Query: 317 MGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDEL 376
M S + PSP PS + ++ +DF FL V+GKG++GKV+LA+R+
Sbjct: 1 MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAF 60
Query: 377 YAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEY 436
YA+K+L+K I++ + + E+ VL R P FL L +FQTP++LYFV++Y
Sbjct: 61 YAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP-----FLVGLRYSFQTPEKLYFVLDY 115
Query: 437 VTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKI 496
V GG+L +H+Q+ +F EP A FYAAE+A + +LH+ IIYRDLK +N++LD +GH+ +
Sbjct: 116 VNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVL 175
Query: 497 TDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFD 556
TDFG+CKE V P TT TFCGTP+Y+APE++ +PY ++VDWW G +LYEML G PPF
Sbjct: 176 TDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFY 235
Query: 557 GEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRW 616
+D ++++ I+ Q + P + A + + L K +RLGS D I+ H FF
Sbjct: 236 SQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKAD-FLEIKNHVFFSP 294
Query: 617 IDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRAAPALT---PPDRLVLASIDQADFQG 672
I+W+ L + PPF P G + ++FD FT+ A + + PD + +S + F G
Sbjct: 295 INWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLG 354
Query: 673 FTYVNPD 679
F+Y D
Sbjct: 355 FSYAPED 361
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 269 bits (687), Expect = 7e-72
Identities = 148/373 (39%), Positives = 215/373 (57%), Gaps = 34/373 (9%)
Query: 313 ERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRG 372
+ + +GPS +P P+ DF FL V+GKGSFGKV+LA+R+
Sbjct: 145 QNINLGPSGNPHAKPT---------------------DFDFLKVIGKGSFGKVLLAKRKL 183
Query: 373 SDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYF 432
+ YA+K+L+K +++ + + E+ VL + P FL LH +FQT ++LYF
Sbjct: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHP-----FLVGLHYSFQTTEKLYF 238
Query: 433 VMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEG 492
V+++V GG+L +H+Q+ F E A FYAAEIA L +LH+ I+YRDLK +N++LD+ G
Sbjct: 239 VLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVG 298
Query: 493 HIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQ 552
H+ +TDFG+CKE + TT TFCGTP+Y+APE+I QPY +VDWW G +LYEML G
Sbjct: 299 HVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGL 358
Query: 553 PPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHG 612
PPF D E++ I+ + ++ +S A +I + L K RLG+ D I+ H
Sbjct: 359 PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKED-FLEIQNHP 417
Query: 613 FFRWIDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRA----APALTPPDRLVLASIDQ 667
FF + W L + +IPPPF P G NFD FT + ++ +V AS+ +
Sbjct: 418 FFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLE 477
Query: 668 AD--FQGFTYVNP 678
AD F GF+Y P
Sbjct: 478 ADDAFVGFSYAPP 490
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.141 0.453
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,006,895
Number of Sequences: 37866
Number of extensions: 1805496
Number of successful extensions: 10036
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 867
Number of HSP's successfully gapped in prelim test: 356
Number of HSP's that attempted gapping in prelim test: 6400
Number of HSP's gapped (non-prelim): 2354
length of query: 697
length of database: 18,247,518
effective HSP length: 109
effective length of query: 588
effective length of database: 14,120,124
effective search space: 8302632912
effective search space used: 8302632912
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.