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Search of human proteins with 51702222
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|51702222 SPT2, Suppressor of Ty, domain containing 1 [Homo
sapiens]
(685 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|51702222 SPT2, Suppressor of Ty, domain containing 1 [Homo sa... 1366 0.0
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens] 79 1e-14
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 74 3e-13
gi|150170670 piccolo isoform 2 [Homo sapiens] 69 2e-11
gi|150378539 piccolo isoform 1 [Homo sapiens] 69 2e-11
gi|28559039 mediator complex subunit 1 [Homo sapiens] 68 2e-11
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 68 3e-11
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 67 5e-11
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 67 5e-11
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 66 9e-11
gi|41281612 zinc finger protein 828 [Homo sapiens] 66 1e-10
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 65 2e-10
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 64 4e-10
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 63 1e-09
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 62 1e-09
gi|33356174 pinin, desmosome associated protein [Homo sapiens] 62 1e-09
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 62 2e-09
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 62 2e-09
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 62 2e-09
gi|32698936 B-cell CLL/lymphoma 9-like [Homo sapiens] 60 5e-09
gi|55750053 atrophin-1 [Homo sapiens] 59 1e-08
gi|55750041 atrophin-1 [Homo sapiens] 59 1e-08
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 59 1e-08
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 59 1e-08
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 59 1e-08
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 59 1e-08
gi|158854042 hypothetical protein LOC222183 [Homo sapiens] 59 2e-08
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 58 3e-08
gi|50843820 sickle tail isoform 1 [Homo sapiens] 58 3e-08
gi|19924099 synapsin I isoform Ia [Homo sapiens] 58 3e-08
>gi|51702222 SPT2, Suppressor of Ty, domain containing 1 [Homo
sapiens]
Length = 685
Score = 1366 bits (3536), Expect = 0.0
Identities = 685/685 (100%), Positives = 685/685 (100%)
Query: 1 MDFREILMIASKGQGVNNVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELRRKAL 60
MDFREILMIASKGQGVNNVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELRRKAL
Sbjct: 1 MDFREILMIASKGQGVNNVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELRRKAL 60
Query: 61 EEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQATESHTSQGTD 120
EEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQATESHTSQGTD
Sbjct: 61 EEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQATESHTSQGTD 120
Query: 121 REYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQ 180
REYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQ
Sbjct: 121 REYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQ 180
Query: 181 FEPVEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGT 240
FEPVEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGT
Sbjct: 181 FEPVEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGT 240
Query: 241 KLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSL 300
KLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSL
Sbjct: 241 KLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSL 300
Query: 301 REGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPH 360
REGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPH
Sbjct: 301 REGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPH 360
Query: 361 NKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTN 420
NKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTN
Sbjct: 361 NKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTN 420
Query: 421 DSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVS 480
DSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVS
Sbjct: 421 DSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVS 480
Query: 481 GLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSE 540
GLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSE
Sbjct: 481 GLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSE 540
Query: 541 TISSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSE 600
TISSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSE
Sbjct: 541 TISSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSE 600
Query: 601 MEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRYMESSWKEQQKEEAKSLRLGM 660
MEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRYMESSWKEQQKEEAKSLRLGM
Sbjct: 601 MEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRYMESSWKEQQKEEAKSLRLGM 660
Query: 661 QEDLEEMRREEEEMQRRRAKKLKRR 685
QEDLEEMRREEEEMQRRRAKKLKRR
Sbjct: 661 QEDLEEMRREEEEMQRRRAKKLKRR 685
>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
Length = 953
Score = 79.3 bits (194), Expect = 1e-14
Identities = 106/454 (23%), Positives = 181/454 (39%), Gaps = 47/454 (10%)
Query: 29 PPKKDPKVKGVQSAAVQAFLKRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKR 88
PP +P + + R +E+ +KA K ++ + +KR + + R K
Sbjct: 290 PPPPEPPTESAWERGL-----RHAKEVLKKATIRKEQEPDFEEKRFTVTIGEDEREFDKE 344
Query: 89 TKDNFHGYNG-IPIEEKSKKRQATESHTSQGTDREYEM-----EEENEFLEYNHAESEQE 142
+ F +N IP + + E + D E E + EN ++Y E
Sbjct: 345 N-EVFRDWNSRIP---RDVRDTVLEPYADPYYDYEIERFWRGGQYENFRVQYTETEPYHN 400
Query: 143 YEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEEL 202
Y E + + E++ + + R E++Q E + ++ +ER EE
Sbjct: 401 YRERERERERENRQRERERERERD-------RERERRQREREREREHERDKERQRRKEEW 453
Query: 203 R----EREFLERKHR----RKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSK 254
+R+ +R+HR K+ E + P S + PS++ K + +G + +
Sbjct: 454 ERERAKRDEKDRQHRDRDREKEREKEKGKPKPRSPQPPSRQAEPPKKEAATTGPQVKRAD 513
Query: 255 GMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIK-AGSGNSSQPSLREGHDKPVFNGAG 313
P KS +K L +S S S R K + S S+ S R ++G+G
Sbjct: 514 EWKDPWRRSKSP-----KKKLGVSVSPSRARRRRKTSASSASASNSSRSSSRSSSYSGSG 568
Query: 314 KPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHN---KAKSPGVRQ 370
S + S S S+ ++ S+ +S S S P P +PH + K
Sbjct: 569 SSRSRSRSSSYSSYSSRSSRHSSFSGSRSRSRSFSSSPSPSPTPSPHRPSIRTKGEPAPP 628
Query: 371 PGSSSSSAPGQPSTGVARP--TVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRT 428
PG + + +P+ A P T ++ PVP + G R ++P + P RRT
Sbjct: 629 PGKAGEKSVKKPAPPPAPPQATKTTAPVPE----PTKPGDPREARRKERPAR-TPPRRRT 683
Query: 429 VSGTCGPGQPASSSGGPGRPISGSVSSARPLGSS 462
+SG+ G G +S SG R S SVSS + S+
Sbjct: 684 LSGS-GSGSGSSYSGSSSRSRSLSVSSVSSVSSA 716
Score = 42.7 bits (99), Expect = 0.001
Identities = 110/559 (19%), Positives = 183/559 (32%), Gaps = 108/559 (19%)
Query: 49 KRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKR 108
+R+ E + E +RRKEE ++R K D+K R R ++ +E+ K++
Sbjct: 433 EREREREHERDKERQRRKEEWERERA--KRDEKDRQHRDRDRE----------KEREKEK 480
Query: 109 QATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEE--------------EQEPPKVES 154
+ + Q R+ E ++ + E+++ P +
Sbjct: 481 GKPKPRSPQPPSRQAEPPKKEAATTGPQVKRADEWKDPWRRSKSPKKKLGVSVSPSRARR 540
Query: 155 KPKVPLKSAPPPMNFTDLLRLAE---------KKQFEPVEIKVVKKSEERPMTAEELRER 205
+ K SA + R + + + + S + R R
Sbjct: 541 RRKTSASSASASNSSRSSSRSSSYSGSGSSRSRSRSSSYSSYSSRSSRHSSFSGSRSRSR 600
Query: 206 EFLERKH-------RRKKLETDGKLPP--------TVSKKAPSQKESVGTKLSKGSGDRH 250
F R + T G+ P +V K AP TK + +
Sbjct: 601 SFSSSPSPSPTPSPHRPSIRTKGEPAPPPGKAGEKSVKKPAPPPAPPQATKTTAPVPE-- 658
Query: 251 PSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNS--------------- 295
P+ G P A +K RP+ + LS S S G S S
Sbjct: 659 PTKPGDPR-EARRKERPARTPPRRRTLSGSGSGSGSSYSGSSSRSRSLSVSSVSSVSSAT 717
Query: 296 -SQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPG 354
S S + ++ P SS SS S P + +R +K K+KK R
Sbjct: 718 SSSSSAHSVDSEDMYADLASPVSSASSRS-PAPAQTRKEKG----KSKKEDGVKEEKRKR 772
Query: 355 PMVT-PHNKAKSPG----VRQPGSSSSSAPGQPSTG--VARPTVSSGPVPRRQNGSSSSG 407
T P AK P +QP + + PGQP G VA + + N ++ G
Sbjct: 773 DSSTQPPKSAKPPAGGKSSQQPSTPQQAPPGQPQQGTFVAHKEIKLTLL----NKAADKG 828
Query: 408 PERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGR 467
+ S K P++R + G R G + S +P +
Sbjct: 829 SRKRYEPSDKDRQSPPPAKRP--------NTSPDRGSRDRKSGGRLGSPKPERQRGQNSK 880
Query: 468 PVSSPHELRRPVSGLGPPGRSV-SGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSS 526
++P + +R +S V S PG++ S PG + G T+S
Sbjct: 881 APAAPADRKRQLSPQSKSSSKVTSVPGKA-------------SDPGAASTKSGKASTLSR 927
Query: 527 SGPTIKPKCTVVSETISSK 545
+K + V + I+ K
Sbjct: 928 REELLK-QLKAVEDAIARK 945
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 74.3 bits (181), Expect = 3e-13
Identities = 107/505 (21%), Positives = 188/505 (37%), Gaps = 80/505 (15%)
Query: 4 REILMIASKGQGVNNVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELRRKALEEK 63
RE L + + + + K+ ++DP+ ++ Q + +E++ R+ +EE+
Sbjct: 353 REFLRLQQENKSNSEALKQQQQLQQQQQRDPEAH-IKHLLHQRQRRIEEQKEERRRVEEQ 411
Query: 64 RRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQATESHTSQGTDREY 123
+R+E +K E + ++ M ++ E++ K++Q E S+ R+
Sbjct: 412 QRREREQRKLQEKEQQRRLEDMQALRREEER--RQAEREQEYKRKQLEEQRQSERLQRQ- 468
Query: 124 EMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEP 183
+++E+ +L+ + +Q+ ++Q+ ++ + PL MN D
Sbjct: 469 -LQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPAD------------ 515
Query: 184 VEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLS 243
+P A E+ ER + ++ + +P K G+
Sbjct: 516 -----------KPAWAREVEERTRMNKQ-----------------QNSPLAKSKPGS--- 544
Query: 244 KGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREG 303
+G P + P P P M KS+ R+ + P +
Sbjct: 545 --TGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSL 602
Query: 304 HDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGP------MV 357
D+P N A P S P++P +A+ + + AV + S P+ PGP V
Sbjct: 603 QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAV----IRQNSDPTSEGPGPSPNPPAWV 658
Query: 358 TPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKK 417
P N+A P V Q SS ++A G +RP + PR + R+ G+ K
Sbjct: 659 RPDNEA-PPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPK 717
Query: 418 PTN-----------DSNPSRRTVSGTCGPGQPASSSGGPGR----PISGSVSSARPLGSS 462
P SNP R PG S S P P +GS+ R SS
Sbjct: 718 PPGPPAQPPGPPNASSNPDLR----RSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSS 773
Query: 463 RGPGRPVSSPHELRRPVSGLGPPGR 487
+ PV SP +P PGR
Sbjct: 774 KPDSSPVLSPGNKAKPDDHRSRPGR 798
Score = 48.9 bits (115), Expect = 2e-05
Identities = 109/486 (22%), Positives = 182/486 (37%), Gaps = 75/486 (15%)
Query: 120 DREYEMEEENEFLEYNHAESEQE---YEEEQEPPKVESKP----------KVPLKSAPPP 166
DR + E E EY ++ SE+E + EE EP + + P ++ ++
Sbjct: 307 DRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNS 366
Query: 167 MNFTDLLRLAEKKQFEP-VEIKVV----------KKSEERPMTAEELRERE--FLERKHR 213
+L +++Q +P IK + +K E R + ++ RERE L+ K +
Sbjct: 367 EALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQ 426
Query: 214 RKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEK 273
+++LE L ++ +++ K + + + HA KS ++
Sbjct: 427 QRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQ 486
Query: 274 HLALSSSKS-MPGER-----IKAGSGNSSQPS-LREGHDKPVFN-------GAGKPHSST 319
L + +PG+R G + +P+ RE ++ N KP S+
Sbjct: 487 QLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTG 546
Query: 320 SSPSVPKTS------ASRT--QKSAVEHKAKKSLSHPSHSRP-GPMVTPHNKAKSPGVRQ 370
P +P+ S S+T + VE + S +H P P P +++S Q
Sbjct: 547 PEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSL-QDQ 605
Query: 371 PGSSSSSAPGQPSTGVARPTVSSGPVPR----RQNGSSSS---GPERSISGSKKPTNDSN 423
P + ++ P A P ++ P R RQN +S GP + +P N++
Sbjct: 606 PTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAP 665
Query: 424 P-------SRRTVSGTCGPGQPASSSGGPGRPISGSV-SSARPLGSSRGPGRPVSSPHEL 475
P S T T G G + RP S S + RG +P P +
Sbjct: 666 PKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQP 725
Query: 476 RRPVSGLGPPGRSVSGPG--RSIS------GSIPAGRTVSNSVPGRPVSSLGPGQTVSSS 527
P + P S PG RS S G +P ++ + G VSS V S
Sbjct: 726 PGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVG--VSSKPDSSPVLSP 783
Query: 528 GPTIKP 533
G KP
Sbjct: 784 GNKAKP 789
Score = 34.3 bits (77), Expect = 0.39
Identities = 27/120 (22%), Positives = 48/120 (40%), Gaps = 8/120 (6%)
Query: 422 SNPSRRTVSGTCGPGQPA-SSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVS 480
++P ++ G+ GP P +S GP P+S + RP+ GP + + + +P +
Sbjct: 534 NSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYA 593
Query: 481 GLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSE 540
P +S+ + PA ++P P T S+ G I+ SE
Sbjct: 594 APVPRSQSLQDQPTRNLAAFPASHDPDPAIP-------APTATPSARGAVIRQNSDPTSE 646
Score = 33.5 bits (75), Expect = 0.67
Identities = 28/110 (25%), Positives = 54/110 (49%), Gaps = 13/110 (11%)
Query: 580 GYKRQREYE----EEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESD 635
G K + EYE EE+DD + E + GE +R F +++ K S+
Sbjct: 314 GEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGEST------LRREFLRLQQENKSNSE 367
Query: 636 YALRYMESSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR 685
AL+ + ++QQ++ ++ + + + R EE++ +RRR ++ +RR
Sbjct: 368 -ALKQQQQLQQQQQRDPEAHIKHLLHQ--RQRRIEEQKEERRRVEEQQRR 414
Score = 30.4 bits (67), Expect = 5.7
Identities = 16/105 (15%), Positives = 54/105 (51%), Gaps = 2/105 (1%)
Query: 581 YKRQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRY 640
++RQR EE+ ++ + + E ++E + + ++ R++ + +++ Y
Sbjct: 392 HQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEY 451
Query: 641 MESSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR 685
+EQ++ E L+ +Q++ ++ +++ Q+++ +K +++
Sbjct: 452 KRKQLEEQRQSE--RLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQ 494
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 68.6 bits (166), Expect = 2e-11
Identities = 93/430 (21%), Positives = 164/430 (38%), Gaps = 59/430 (13%)
Query: 123 YEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFE 182
+++ ++E + + ++ ++EQ P+ KP PL+ PP KQ
Sbjct: 176 FDLISDSEASQEETTKKQKVVQKEQGKPEGIIKP--PLQQQPPK---------PIPKQQG 224
Query: 183 PVEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKL 242
P + + + +++++ E+ + K ++ + P T K P Q+++ +
Sbjct: 225 PGRDPLQQDGTPKSISSQQ-PEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQT 283
Query: 243 SKGSGDRHPSSK-GMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAG--SGNSSQPS 299
+ R S K +P P +P+ KS PG SG + +
Sbjct: 284 KQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLA 343
Query: 300 LREGHDKPVFN--GAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSH------S 351
+ G KP G KP + P+ P + ++K + E K+L+ P
Sbjct: 344 QQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQ 403
Query: 352 RPGPMVTPHNKAKSPG--VRQPG-SSSSSAPGQPSTGVARPTVSSGPVPRRQNG-----S 403
+PGP P + +P +QPG S + APG T V +P G +P +Q G +
Sbjct: 404 QPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQP--GPGKIPAQQAGPGKTSA 461
Query: 404 SSSGPERSIS-----------------------GSKKPTNDSNPSRRTVSGTCGPGQPAS 440
+GP + S GS KP + S + GP +P+
Sbjct: 462 QQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSP 521
Query: 441 SSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSISGSI 500
G +P S SA+P P +P S + +PVS G G+ + P S S
Sbjct: 522 QQPGSTKPPSQQPGSAKPSAQQPSPAKP--SAQQSTKPVSQTG-SGKPLQPPTVSPSAKQ 578
Query: 501 PAGRTVSNSV 510
P + + ++
Sbjct: 579 PPSQGLPKTI 588
Score = 53.1 bits (126), Expect = 8e-07
Identities = 79/373 (21%), Positives = 134/373 (35%), Gaps = 62/373 (16%)
Query: 137 AESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERP 196
A S+ + +Q PK ++ PK L AP P L++ +P ++P
Sbjct: 671 AVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVK-------QPTLHGSPSAKAKQP 723
Query: 197 MTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGS-GDRHPSSKG 255
A+ L SK AP ++ SV ++ K D P
Sbjct: 724 PEADSL-------------------------SKPAPPKEPSVPSEQDKAPVADDKPKQPK 758
Query: 256 MPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKP--VFNGAG 313
M P + S S ++ +P ++++ + + P L+ KP F G
Sbjct: 759 MVKPTTDLVSSSS--------ATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTG 810
Query: 314 KPHSSTSSPSVPKTSASRTQKS----AVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVR 369
+ S S ++P+ ++ S + E K +K + P + P + P +
Sbjct: 811 EKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVD-PVQKKEEPKKAQTKMSPKPDAK 869
Query: 370 QPGSSSSSAPG-QPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRT 428
S + PG +P+ G PT P P+ Q+ R S + D+ S+ T
Sbjct: 870 PMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQS--------RRFSLNLGSITDAPKSQPT 921
Query: 429 VSGTCGPGQPASSSGGPGRPISGSVSSARPLG--SSRGPGRPVSSPHELRRPVSGLGPP- 485
G+ S +S+A G S GPG P+ +P + GPP
Sbjct: 922 TPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPK 981
Query: 486 --GRSVSGPGRSI 496
G++ P +SI
Sbjct: 982 STGQAPPAPAKSI 994
Score = 45.1 bits (105), Expect = 2e-04
Identities = 109/530 (20%), Positives = 192/530 (36%), Gaps = 81/530 (15%)
Query: 151 KVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTA------EELRE 204
K+ P P K++P P+ + +K P ++K+VKK E+ T E+++E
Sbjct: 1124 KMPPAPSGP-KASPMPVPTES----SSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKE 1178
Query: 205 REFLER---------KHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKG 255
+E+ K KLE D K P +K+ + + S ++ P +
Sbjct: 1179 TLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEE 1238
Query: 256 MPLPHAEKKSRP-----SMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFN 310
+KK P + +KH L S + E+++ G + +++EG +P
Sbjct: 1239 KKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLE---GRVAPKTVQEG-KQPQTK 1294
Query: 311 GAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQ 370
G P S + S+PK +T K+ E + P PG T KS
Sbjct: 1295 MEGLP--SGTPQSLPKED-DKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKS----- 1346
Query: 371 PGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVS 430
+SSS P P G++ SS + SSS G S+ + + + + S
Sbjct: 1347 -DTSSSQQPKSPQ-GLSDTGYSSDGI------SSSLGEIPSLIPTDEKDILKGLKKDSFS 1398
Query: 431 GTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVS 490
P P+ + +S + A L + + + PHE + P
Sbjct: 1399 QESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKK--TQPHE-------VSPEQPKDQ 1449
Query: 491 GPGRSISGSIP---AGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSETISSKNI 547
+S+S ++ + + S R + Q S K K V + + +
Sbjct: 1450 EKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRRE- 1508
Query: 548 ISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEMEDFIED 607
P + + P P +R+R DEY E +
Sbjct: 1509 --------------PYDSVEESSESENSPVP---QRKRRTSVGSSSSDEYKQEDS---QG 1548
Query: 608 EGEPQEEISKHIREIFGYDRKKYKDESDY---ALRYMESSWKEQQKEEAK 654
GE ++ I K I E+ + ++ ++ L+ + SS + Q+KEE K
Sbjct: 1549 SGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETK 1598
Score = 41.2 bits (95), Expect = 0.003
Identities = 77/353 (21%), Positives = 120/353 (33%), Gaps = 37/353 (10%)
Query: 209 ERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKG-------SGDRHPSSKGMPLPHA 261
E +K E D PP S + P LSK S + P +
Sbjct: 77 ESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLK 136
Query: 262 EKKSRPSMANEKHLALSSSKSMPG--ERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSST 319
E KSR + E S MPG + A S SS + D + A + ++
Sbjct: 137 ESKSRTDLKEEH-----KSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTK 191
Query: 320 SSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNK---AKSPGVRQPGSSSS 376
V K + ++ ++ P + GP P + KS +QP S
Sbjct: 192 KQKVVQKEQGK--PEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKS 249
Query: 377 SAPG--QPSTGVAR-PTVSSGPVPRRQNGSSSSGPERSI--SGSKKPTNDSNPSRRTVSG 431
PG +P G + P +P +++ S + I S KP+ S PS+ +
Sbjct: 250 QPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPS-PSKPPIQQ 308
Query: 432 TCGPGQPAS-------SSGGPGRPISGSVSSARPL----GSSRGPGRPVSSPHELRRPVS 480
PG+P + S GP +P + +PL G+ + P +P + +P+
Sbjct: 309 PT-PGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLG 367
Query: 481 GLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKP 533
PP + S P V P GP + + T KP
Sbjct: 368 PAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKP 420
Score = 35.0 bits (79), Expect = 0.23
Identities = 70/338 (20%), Positives = 128/338 (37%), Gaps = 43/338 (12%)
Query: 30 PKKDPKVKGVQSAAVQAFLKRKEEELRRKALEEKRRKEELVKKRIE--LKHDKKARAMAK 87
PK P +S++ + + + + ++++ E K E+++ ++++ L +K +
Sbjct: 1132 PKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTT 1191
Query: 88 RTKDNFHGYNGIPIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQ 147
K E K +K +A+ + E ++ E E + +E ++ EE+
Sbjct: 1192 DQKQE---------ESKLEKDKASALQEKKPLPEEKKLIPEEEKIR---SEEKKPLLEEK 1239
Query: 148 EPPKVESKPKVPLKSAPPPMNFTDLLR----LAEKKQFEPVEIKVVKKSEERPMTAEEL- 202
+P + K K++ P DLL+ +AE+K V K V++ ++ E L
Sbjct: 1240 KPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLP 1299
Query: 203 --REREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPH 260
+ + + K + PP +K P Q E K K SS P
Sbjct: 1300 SGTPQSLPKEDDKTTKTIKEQPQPPCTAK--PDQVEPGKEKTEKEDDKSDTSSSQQP--- 1354
Query: 261 AEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGK-PHSST 319
KS +++ + + S S+ PSL +K + G K S
Sbjct: 1355 ---KSPQGLSDTGYSSDGISSSL-----------GEIPSLIPTDEKDILKGLKKDSFSQE 1400
Query: 320 SSPSVPKTSA--SRTQKSAVEHKAKKSLSHPSHSRPGP 355
SSPS P A T S +E +A S + P
Sbjct: 1401 SSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQP 1438
Score = 31.6 bits (70), Expect = 2.5
Identities = 24/71 (33%), Positives = 33/71 (46%), Gaps = 10/71 (14%)
Query: 313 GKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHP----SHSRPGPMVTPHNKAKSPG- 367
GK HSS SS PK S +++ + K + P SHS PG +K+ S G
Sbjct: 4835 GKSHSSQSSQQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPG-----SSKSSSEGH 4889
Query: 368 VRQPGSSSSSA 378
+R G S S +
Sbjct: 4890 LRSHGPSRSQS 4900
Score = 30.0 bits (66), Expect = 7.4
Identities = 30/107 (28%), Positives = 47/107 (43%), Gaps = 13/107 (12%)
Query: 51 KEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQA 110
+EEELR EE+ KE+ ++ IE + K + +K+ KD E+ K +
Sbjct: 1775 EEEELRE---EEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRR---RERPKTPPS 1828
Query: 111 TESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPK 157
S + E E+ + E +E H S EY P +ES P+
Sbjct: 1829 NLSPIEDASPTE-ELRQAAE-MEELHRSSCSEYS-----PSIESDPE 1868
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 68.6 bits (166), Expect = 2e-11
Identities = 93/430 (21%), Positives = 164/430 (38%), Gaps = 59/430 (13%)
Query: 123 YEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFE 182
+++ ++E + + ++ ++EQ P+ KP PL+ PP KQ
Sbjct: 176 FDLISDSEASQEETTKKQKVVQKEQGKPEGIIKP--PLQQQPPK---------PIPKQQG 224
Query: 183 PVEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKL 242
P + + + +++++ E+ + K ++ + P T K P Q+++ +
Sbjct: 225 PGRDPLQQDGTPKSISSQQ-PEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQT 283
Query: 243 SKGSGDRHPSSK-GMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAG--SGNSSQPS 299
+ R S K +P P +P+ KS PG SG + +
Sbjct: 284 KQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLA 343
Query: 300 LREGHDKPVFN--GAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSH------S 351
+ G KP G KP + P+ P + ++K + E K+L+ P
Sbjct: 344 QQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQ 403
Query: 352 RPGPMVTPHNKAKSPG--VRQPG-SSSSSAPGQPSTGVARPTVSSGPVPRRQNG-----S 403
+PGP P + +P +QPG S + APG T V +P G +P +Q G +
Sbjct: 404 QPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQP--GPGKIPAQQAGPGKTSA 461
Query: 404 SSSGPERSIS-----------------------GSKKPTNDSNPSRRTVSGTCGPGQPAS 440
+GP + S GS KP + S + GP +P+
Sbjct: 462 QQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSP 521
Query: 441 SSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSISGSI 500
G +P S SA+P P +P S + +PVS G G+ + P S S
Sbjct: 522 QQPGSTKPPSQQPGSAKPSAQQPSPAKP--SAQQSTKPVSQTG-SGKPLQPPTVSPSAKQ 578
Query: 501 PAGRTVSNSV 510
P + + ++
Sbjct: 579 PPSQGLPKTI 588
Score = 53.1 bits (126), Expect = 8e-07
Identities = 79/373 (21%), Positives = 134/373 (35%), Gaps = 62/373 (16%)
Query: 137 AESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERP 196
A S+ + +Q PK ++ PK L AP P L++ +P ++P
Sbjct: 671 AVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVK-------QPTLHGSPSAKAKQP 723
Query: 197 MTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGS-GDRHPSSKG 255
A+ L SK AP ++ SV ++ K D P
Sbjct: 724 PEADSL-------------------------SKPAPPKEPSVPSEQDKAPVADDKPKQPK 758
Query: 256 MPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKP--VFNGAG 313
M P + S S ++ +P ++++ + + P L+ KP F G
Sbjct: 759 MVKPTTDLVSSSS--------ATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTG 810
Query: 314 KPHSSTSSPSVPKTSASRTQKS----AVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVR 369
+ S S ++P+ ++ S + E K +K + P + P + P +
Sbjct: 811 EKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVD-PVQKKEEPKKAQTKMSPKPDAK 869
Query: 370 QPGSSSSSAPG-QPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRT 428
S + PG +P+ G PT P P+ Q+ R S + D+ S+ T
Sbjct: 870 PMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQS--------RRFSLNLGSITDAPKSQPT 921
Query: 429 VSGTCGPGQPASSSGGPGRPISGSVSSARPLG--SSRGPGRPVSSPHELRRPVSGLGPP- 485
G+ S +S+A G S GPG P+ +P + GPP
Sbjct: 922 TPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPK 981
Query: 486 --GRSVSGPGRSI 496
G++ P +SI
Sbjct: 982 STGQAPPAPAKSI 994
Score = 45.1 bits (105), Expect = 2e-04
Identities = 109/530 (20%), Positives = 192/530 (36%), Gaps = 81/530 (15%)
Query: 151 KVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTA------EELRE 204
K+ P P K++P P+ + +K P ++K+VKK E+ T E+++E
Sbjct: 1124 KMPPAPSGP-KASPMPVPTES----SSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKE 1178
Query: 205 REFLER---------KHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKG 255
+E+ K KLE D K P +K+ + + S ++ P +
Sbjct: 1179 TLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEE 1238
Query: 256 MPLPHAEKKSRP-----SMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFN 310
+KK P + +KH L S + E+++ G + +++EG +P
Sbjct: 1239 KKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLE---GRVAPKTVQEG-KQPQTK 1294
Query: 311 GAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQ 370
G P S + S+PK +T K+ E + P PG T KS
Sbjct: 1295 MEGLP--SGTPQSLPKED-DKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKS----- 1346
Query: 371 PGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVS 430
+SSS P P G++ SS + SSS G S+ + + + + S
Sbjct: 1347 -DTSSSQQPKSPQ-GLSDTGYSSDGI------SSSLGEIPSLIPTDEKDILKGLKKDSFS 1398
Query: 431 GTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVS 490
P P+ + +S + A L + + + PHE + P
Sbjct: 1399 QESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKK--TQPHE-------VSPEQPKDQ 1449
Query: 491 GPGRSISGSIP---AGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSETISSKNI 547
+S+S ++ + + S R + Q S K K V + + +
Sbjct: 1450 EKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRRE- 1508
Query: 548 ISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEMEDFIED 607
P + + P P +R+R DEY E +
Sbjct: 1509 --------------PYDSVEESSESENSPVP---QRKRRTSVGSSSSDEYKQEDS---QG 1548
Query: 608 EGEPQEEISKHIREIFGYDRKKYKDESDY---ALRYMESSWKEQQKEEAK 654
GE ++ I K I E+ + ++ ++ L+ + SS + Q+KEE K
Sbjct: 1549 SGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETK 1598
Score = 41.2 bits (95), Expect = 0.003
Identities = 77/353 (21%), Positives = 120/353 (33%), Gaps = 37/353 (10%)
Query: 209 ERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKG-------SGDRHPSSKGMPLPHA 261
E +K E D PP S + P LSK S + P +
Sbjct: 77 ESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLK 136
Query: 262 EKKSRPSMANEKHLALSSSKSMPG--ERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSST 319
E KSR + E S MPG + A S SS + D + A + ++
Sbjct: 137 ESKSRTDLKEEH-----KSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTK 191
Query: 320 SSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNK---AKSPGVRQPGSSSS 376
V K + ++ ++ P + GP P + KS +QP S
Sbjct: 192 KQKVVQKEQGK--PEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKS 249
Query: 377 SAPG--QPSTGVAR-PTVSSGPVPRRQNGSSSSGPERSI--SGSKKPTNDSNPSRRTVSG 431
PG +P G + P +P +++ S + I S KP+ S PS+ +
Sbjct: 250 QPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPS-PSKPPIQQ 308
Query: 432 TCGPGQPAS-------SSGGPGRPISGSVSSARPL----GSSRGPGRPVSSPHELRRPVS 480
PG+P + S GP +P + +PL G+ + P +P + +P+
Sbjct: 309 PT-PGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLG 367
Query: 481 GLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKP 533
PP + S P V P GP + + T KP
Sbjct: 368 PAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKP 420
Score = 35.0 bits (79), Expect = 0.23
Identities = 70/338 (20%), Positives = 128/338 (37%), Gaps = 43/338 (12%)
Query: 30 PKKDPKVKGVQSAAVQAFLKRKEEELRRKALEEKRRKEELVKKRIE--LKHDKKARAMAK 87
PK P +S++ + + + + ++++ E K E+++ ++++ L +K +
Sbjct: 1132 PKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTT 1191
Query: 88 RTKDNFHGYNGIPIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQ 147
K E K +K +A+ + E ++ E E + +E ++ EE+
Sbjct: 1192 DQKQE---------ESKLEKDKASALQEKKPLPEEKKLIPEEEKIR---SEEKKPLLEEK 1239
Query: 148 EPPKVESKPKVPLKSAPPPMNFTDLLR----LAEKKQFEPVEIKVVKKSEERPMTAEEL- 202
+P + K K++ P DLL+ +AE+K V K V++ ++ E L
Sbjct: 1240 KPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLP 1299
Query: 203 --REREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPH 260
+ + + K + PP +K P Q E K K SS P
Sbjct: 1300 SGTPQSLPKEDDKTTKTIKEQPQPPCTAK--PDQVEPGKEKTEKEDDKSDTSSSQQP--- 1354
Query: 261 AEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGK-PHSST 319
KS +++ + + S S+ PSL +K + G K S
Sbjct: 1355 ---KSPQGLSDTGYSSDGISSSL-----------GEIPSLIPTDEKDILKGLKKDSFSQE 1400
Query: 320 SSPSVPKTSA--SRTQKSAVEHKAKKSLSHPSHSRPGP 355
SSPS P A T S +E +A S + P
Sbjct: 1401 SSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQP 1438
Score = 34.3 bits (77), Expect = 0.39
Identities = 42/151 (27%), Positives = 62/151 (41%), Gaps = 25/151 (16%)
Query: 313 GKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHP----SHSRPGPMVTPHNKAKSPG- 367
GK HSS SS PK S +++ + K + P SHS PG +K+ S G
Sbjct: 4835 GKSHSSQSSQQSPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSSPG-----SSKSSSEGH 4889
Query: 368 VRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSK-KPTNDSNPSR 426
+R G S S Q T V + + G++ + E ++ + +PT P+
Sbjct: 4890 LRSHGPSRS----QSKTSVTQTHLEDA-------GAAIAAAEAAVQQLRIQPTKP--PNH 4936
Query: 427 RTVSGTCGPGQPASSSG-GPGRPISGSVSSA 456
R + G SS G G GS S+A
Sbjct: 4937 RPAESSVSTGSSGSSFGSGYSVDSEGSSSTA 4967
Score = 30.0 bits (66), Expect = 7.4
Identities = 30/107 (28%), Positives = 47/107 (43%), Gaps = 13/107 (12%)
Query: 51 KEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQA 110
+EEELR EE+ KE+ ++ IE + K + +K+ KD E+ K +
Sbjct: 1775 EEEELRE---EEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRR---RERPKTPPS 1828
Query: 111 TESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPK 157
S + E E+ + E +E H S EY P +ES P+
Sbjct: 1829 NLSPIEDASPTE-ELRQAAE-MEELHRSSCSEYS-----PSIESDPE 1868
>gi|28559039 mediator complex subunit 1 [Homo sapiens]
Length = 1581
Score = 68.2 bits (165), Expect = 2e-11
Identities = 121/520 (23%), Positives = 170/520 (32%), Gaps = 111/520 (21%)
Query: 209 ERKHRRKKLETDGKLPPTVSKKAP-SQKESVGTKLSKGSGDRHPSSKGMPLPHAEK---- 263
++ +RKK +T+GK P S P + S G S GS R + G+ P K
Sbjct: 1007 DKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSAGRSQTPPGVATPPIPKITIQ 1066
Query: 264 -----------------------KSRPSMANEKHLALSSSKSMPGERIKAGSGN------ 294
S S ++ H + SSS + ++K+
Sbjct: 1067 IPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSK 1126
Query: 295 ------SSQPSLREGHDKPVFNGAGKP-------HSSTSSPSVPKTSASRTQKSAVEHKA 341
SSQ S K GKP H +S S K S +
Sbjct: 1127 LSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSL 1186
Query: 342 KKSLSHPSHSRPG-------------PMVTPHNKAKSP------GVRQPGSSSSSAPGQP 382
K PSHSRP P P +KAKSP G G+SSSS +
Sbjct: 1187 SKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGM-KS 1245
Query: 383 STGVARPTVSSGPVPRRQNGSSSSGPERSISGS--------------KKPTNDSNPSRRT 428
S+G+ S P N ++S S SGS K P+ + PS
Sbjct: 1246 SSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTA 1305
Query: 429 VSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHEL-------RRPVSG 481
V G S GG P+ G + S+ P+SS H + +R S
Sbjct: 1306 VIDKLKHGVVTSGPGGED-PLDGQMGV-----STNSSSHPMSSKHNMSGGEFQGKREKSD 1359
Query: 482 LGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSS----SGPTIKPKCTV 537
S SG S+ + + S S + V S G + + S P+IK K T+
Sbjct: 1360 KDKSKVSTSG------SSVDSSKKTSES---KNVGSTGVAKIIISKHDGGSPSIKAKVTL 1410
Query: 538 VSETISSKNIISRSSNGQMNGMKPPLSGYRAAQ---GPQRLPFPTGYKRQREYEEEDDDD 594
SS + N P +SG P P + + E E
Sbjct: 1411 QKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSS 1470
Query: 595 DEYDSEMEDFIEDEG-EPQEEISKHIREIFGYDRKKYKDE 633
S D+G P E S + ++KK KD+
Sbjct: 1471 IAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDK 1510
Score = 65.9 bits (159), Expect = 1e-10
Identities = 101/438 (23%), Positives = 151/438 (34%), Gaps = 76/438 (17%)
Query: 281 KSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHK 340
K +R+K G+G S+ G D KP + +PS S + K
Sbjct: 965 KEKTQKRVKEGNGTSNSTLSGPGLDS-------KPGKRSRTPSNDGKSKDKPPKRKKADT 1017
Query: 341 AKKSLSHPSHSRPGPMVTPHNKAKSPG-----VRQPGSSSSSAP-------------GQP 382
KS SH S +RP T +KSPG PG ++ P G+P
Sbjct: 1018 EGKSPSHSSSNRPFTPPTSTGGSKSPGSAGRSQTPPGVATPPIPKITIQIPKGTVMVGKP 1077
Query: 383 STG---VARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVS-------GT 432
S+ + +VSS + SSSS S SG K + S +S G+
Sbjct: 1078 SSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGS 1137
Query: 433 CGPGQPASSSGGPGRPISGSVSS-ARPLGSSRGPGRPVSSPHELRRP--------VSGLG 483
G Q +SS G+P S ++ GSS +P P L P S
Sbjct: 1138 SGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSR 1197
Query: 484 PPGRS--VSGPGRSISGSIPAGRT---------------VSNSVPGRPVSSLGPGQTVSS 526
PPG S ++ P + + G+ P+ + S+S + S LG ++S
Sbjct: 1198 PPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQ 1257
Query: 527 SGPTIKPKCTVVSETISSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPT-----GY 581
P CT S + SS SS Q K + P R P+
Sbjct: 1258 KTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSK--------GKSPSRNKKPSLTAVIDK 1309
Query: 582 KRQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRYM 641
+ +D D +M P SKH + K+ K + D +
Sbjct: 1310 LKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMS--SKHNMSGGEFQGKREKSDKDKSKVST 1367
Query: 642 ESSWKEQQKEEAKSLRLG 659
S + K+ ++S +G
Sbjct: 1368 SGSSVDSSKKTSESKNVG 1385
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 67.8 bits (164), Expect = 3e-11
Identities = 105/468 (22%), Positives = 173/468 (36%), Gaps = 46/468 (9%)
Query: 46 AFLKRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKS 105
AFL+ K+EE++++ +E+++ + + K DK+ + ++ ++ P KS
Sbjct: 122 AFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRS----PRRRKS 177
Query: 106 KKRQATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPP 165
+ + +R+ + + S ++E+ P E KV S
Sbjct: 178 RSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQE 237
Query: 166 PMNFTDLLRLAEKKQF----EPVEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDG 221
+ +D+L++ + + EP K KK +E+ T R R + R + +
Sbjct: 238 ATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSR---SKSRSRTRSRSPS 294
Query: 222 KLPPTVSKKAPSQKESVGTKLS---KGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALS 278
P ++ S+ S + S + S R + MP P ++SR + +
Sbjct: 295 HTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRR---- 350
Query: 279 SSKSMPGERIKAGSGNSSQPSLR--EGHDKPV-----FNGAGKPHSSTSSPSVPKTSASR 331
SS S+ G + S S P + + P + + P PS P T +
Sbjct: 351 SSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPK 410
Query: 332 TQKSAV---EHKAKKSLSHPSHSRPGPMVTPH---NKAKSPGVRQPGSSSSSAPGQPSTG 385
T+ S ++ +KS S R VT H K +SP + + G
Sbjct: 411 TRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKG 470
Query: 386 ---VARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTV-SGTCGPGQPASS 441
A +V RRQN SSS SGS + D P R V +G G + S
Sbjct: 471 GKMAAADSVQQRRQYRRQNQQSSSD-----SGSSSSSEDERPKRSHVKNGEVGRRRRHS- 524
Query: 442 SGGPGRPISGSVSSARPLGSSRGPGR--PVSSPHELRRPVSGLGPPGR 487
P R S S + S RG R P P RR S PP R
Sbjct: 525 ---PSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRR 569
Score = 59.3 bits (142), Expect = 1e-08
Identities = 104/441 (23%), Positives = 154/441 (34%), Gaps = 71/441 (16%)
Query: 196 PMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRH----- 250
P EL++ E +R+ ++KL + K K+ +KES K + R
Sbjct: 120 PSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRS 179
Query: 251 PSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGER------IKAGSGNSSQPSLREGH 304
PS + P ++ R + +H S S S E+ + S +PS++E
Sbjct: 180 PSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEAT 239
Query: 305 DKPVFNGAGKPHS--STSSPSVPKTSASRTQKSAVEHKAK---KSLSH-----PSHSRPG 354
KP PS K S +K +++ KS S PSH+RP
Sbjct: 240 STSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPR 299
Query: 355 PMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISG 414
+++ SP R+P S +PS P P PR + S R S
Sbjct: 300 RRHRSRSRSYSPR-RRP-----SPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSA 353
Query: 415 SKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHE 474
S ++ S+ S R+ S P +P + P R SA P P P + P +
Sbjct: 354 SLSGSSSSSSSSRSRS---PPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPK 410
Query: 475 LRRPVSGLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPK 534
R P S R S+ GRT G+ G + S S P KP+
Sbjct: 411 TRH------SPTPQQSNRTRKSRVSVSPGRT-----SGKVTKHKGTEKRESPS-PAPKPR 458
Query: 535 CTVVSETISSK-------------------NIISRSSNGQMNGM---KPPLS-------G 565
+SE+ K N S S +G + +P S G
Sbjct: 459 KVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVG 518
Query: 566 YRAAQGPQRLPFPTGYKRQRE 586
R P R P+ KRQ+E
Sbjct: 519 RRRRHSPSRSASPSPRKRQKE 539
Score = 51.2 bits (121), Expect = 3e-06
Identities = 92/403 (22%), Positives = 138/403 (34%), Gaps = 55/403 (13%)
Query: 231 APSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKA 290
+PS ++ +G R PS P ++ PS A + + P R +
Sbjct: 530 SPSPRKRQKETSPRGRRRRSPSP-----PPTRRRRSPSPAPPPRRRRTPTPP-PRRRTPS 583
Query: 291 GSGNSSQPSLREGHDKPV---FNGAGKPHSSTSSPSVP---KTSASRTQKSAVEHKAK-K 343
PS R + P+ ++ + P T+SP P + S S K V H K
Sbjct: 584 PPPRRRSPSPRR-YSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPK 642
Query: 344 SLSHPSHSRPGPMVTP-HNKAKSPG--VRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQ 400
S P R P ++ H K SP R+ S + PS P SS P P R+
Sbjct: 643 QRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRR 702
Query: 401 NGSSSSGPERSISGSKKPTN--DSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARP 458
SSS +S S S +P P + + P + R +SGS P
Sbjct: 703 GASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGS-----P 757
Query: 459 LGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSL 518
+++ P P S PV P + S ++P + S P S
Sbjct: 758 EPAAKKPPAPPS-------PVQS--------QSPSTNWSPAVPVKKAKS------PTPSP 796
Query: 519 GPGQTVSSSGPTIKPKCTVVSETISSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFP 578
P + G K K + K + + K + AA P +
Sbjct: 797 SPPRNSDQEGGGKKKK---KKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAA 853
Query: 579 TGYKRQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIRE 621
T Q E + E +SE ED ++D + KH+RE
Sbjct: 854 TTTLAQEEPVAAPEPKKETESEAEDNLDD-------LEKHLRE 889
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 67.0 bits (162), Expect = 5e-11
Identities = 100/476 (21%), Positives = 183/476 (38%), Gaps = 73/476 (15%)
Query: 4 REILMIASKGQGVNNVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELRRKALEEK 63
RE L + + + + K+ ++DP+ ++ Q + +E++ R+ +EE+
Sbjct: 353 REFLRLQQENKSNSEALKQQQQLQQQQQRDPEAH-IKHLLHQRQRRIEEQKEERRRVEEQ 411
Query: 64 RRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQATESHTSQGTDREY 123
+R+E +K E + ++ M ++ E++ K++Q E S+ R+
Sbjct: 412 QRREREQRKLQEKEQQRRLEDMQALRREEER--RQAEREQEYKRKQLEEQRQSERLQRQ- 468
Query: 124 EMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEP 183
+++E+ +L+ + +Q+ ++Q+ ++ + PL MN D
Sbjct: 469 -LQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPAD------------ 515
Query: 184 VEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLS 243
+P A E+ ER + ++ + +P K G+
Sbjct: 516 -----------KPAWAREVEERTRMNKQ-----------------QNSPLAKSKPGS--- 544
Query: 244 KGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREG 303
+G P + P P P M KS+ R+ + P +
Sbjct: 545 --TGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSL 602
Query: 304 HDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGP------MV 357
D+P N A P S P++P +A+ + + AV + S P+ PGP V
Sbjct: 603 QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAV----IRQNSDPTSEGPGPSPNPPAWV 658
Query: 358 TPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTV---SSGPVPRRQNGSSSSGPERSISG 414
P N+A P V Q SS ++A G +RP +S P RR S G ER S
Sbjct: 659 RPDNEA-PPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRR----SDPGWER--SD 711
Query: 415 SKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVS 470
S P + + + +G+ + SS P+ + A+P PGRP S
Sbjct: 712 SVLPASHGHLPQ---AGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPAS 764
Score = 51.6 bits (122), Expect = 2e-06
Identities = 103/464 (22%), Positives = 167/464 (35%), Gaps = 99/464 (21%)
Query: 120 DREYEMEEENEFLEYNHAESEQE---YEEEQEPPKVESKP----------KVPLKSAPPP 166
DR + E E EY ++ SE+E + EE EP + + P ++ ++
Sbjct: 307 DRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNS 366
Query: 167 MNFTDLLRLAEKKQFEP-VEIKVV----------KKSEERPMTAEELRERE--FLERKHR 213
+L +++Q +P IK + +K E R + ++ RERE L+ K +
Sbjct: 367 EALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQ 426
Query: 214 RKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEK 273
+++LE L ++ +++ K + + + HA KS ++
Sbjct: 427 QRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQ 486
Query: 274 HLALSSSKS-MPGER-----IKAGSGNSSQPS-LREGHDKPVFN-------GAGKPHSST 319
L + +PG+R G + +P+ RE ++ N KP S+
Sbjct: 487 QLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTG 546
Query: 320 SSPSVPKTS------ASRT-------------QKSAVEHK-------------------- 340
P +P+ S S+T KS V H+
Sbjct: 547 PEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQP 606
Query: 341 ----AKKSLSH-PSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVA--RPTVSS 393
A SH P + P P TP A+ +RQ +S PG A RP +
Sbjct: 607 TRNLAAFPASHDPDPAIPAPTATP--SARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEA 664
Query: 394 GPVPRRQNGSSSSGPERSISGSKKP---TNDSNPSRRTVSGTCGPGQPASSSGGPGR--- 447
P ++ S ++ S +G +P SNP R PG S S P
Sbjct: 665 PPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLR----RSDPGWERSDSVLPASHGH 720
Query: 448 -PISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVS 490
P +GS+ R SS+ PV SP +P PGR S
Sbjct: 721 LPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPAS 764
Score = 34.3 bits (77), Expect = 0.39
Identities = 27/120 (22%), Positives = 48/120 (40%), Gaps = 8/120 (6%)
Query: 422 SNPSRRTVSGTCGPGQPA-SSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVS 480
++P ++ G+ GP P +S GP P+S + RP+ GP + + + +P +
Sbjct: 534 NSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYA 593
Query: 481 GLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSE 540
P +S+ + PA ++P P T S+ G I+ SE
Sbjct: 594 APVPRSQSLQDQPTRNLAAFPASHDPDPAIP-------APTATPSARGAVIRQNSDPTSE 646
Score = 33.5 bits (75), Expect = 0.67
Identities = 28/110 (25%), Positives = 54/110 (49%), Gaps = 13/110 (11%)
Query: 580 GYKRQREYE----EEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESD 635
G K + EYE EE+DD + E + GE +R F +++ K S+
Sbjct: 314 GEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGEST------LRREFLRLQQENKSNSE 367
Query: 636 YALRYMESSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR 685
AL+ + ++QQ++ ++ + + + R EE++ +RRR ++ +RR
Sbjct: 368 -ALKQQQQLQQQQQRDPEAHIKHLLHQ--RQRRIEEQKEERRRVEEQQRR 414
Score = 30.4 bits (67), Expect = 5.7
Identities = 16/105 (15%), Positives = 54/105 (51%), Gaps = 2/105 (1%)
Query: 581 YKRQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRY 640
++RQR EE+ ++ + + E ++E + + ++ R++ + +++ Y
Sbjct: 392 HQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEY 451
Query: 641 MESSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR 685
+EQ++ E L+ +Q++ ++ +++ Q+++ +K +++
Sbjct: 452 KRKQLEEQRQSE--RLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQ 494
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 67.0 bits (162), Expect = 5e-11
Identities = 120/581 (20%), Positives = 211/581 (36%), Gaps = 89/581 (15%)
Query: 4 REILMIASKGQGVNNVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELRRKALEEK 63
RE L + + + + K+ ++DP+ ++ Q + +E++ R+ +EE+
Sbjct: 353 REFLRLQQENKSNSEALKQQQQLQQQQQRDPEAH-IKHLLHQRQRRIEEQKEERRRVEEQ 411
Query: 64 RRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQATESHTSQGTDREY 123
+R+E +K E + ++ M ++ E++ K++Q E S+ R+
Sbjct: 412 QRREREQRKLQEKEQQRRLEDMQALRREEER--RQAEREQEYKRKQLEEQRQSERLQRQ- 468
Query: 124 EMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEP 183
+++E+ +L+ + +Q+ ++Q+ ++ + PL MN D
Sbjct: 469 -LQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPAD------------ 515
Query: 184 VEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLS 243
+P A E+ ER + ++ + +P K G+
Sbjct: 516 -----------KPAWAREVEERTRMNKQ-----------------QNSPLAKSKPGS--- 544
Query: 244 KGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREG 303
+G P + P P P M KS+ R+ + P +
Sbjct: 545 --TGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSL 602
Query: 304 HDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGP------MV 357
D+P N A P S P++P +A+ + + AV + S P+ PGP V
Sbjct: 603 QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAV----IRQNSDPTSEGPGPSPNPPAWV 658
Query: 358 TPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTV---SSGPVPRRQNGSSSSGPERSIS- 413
P N+A P V Q SS ++A G +RP +S P RR S G ERS S
Sbjct: 659 RPDNEA-PPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRR----SDPGWERSDSV 713
Query: 414 -----------GSKKPTNDSNPSRRTVSGTCGPG---QPASSSGGPGRPISGSVSSARPL 459
GS + S+ S PG +P PGRP + R L
Sbjct: 714 LPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTL 773
Query: 460 GSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSISGSIPAGRT--VSNSVPGRPVSS 517
+ P + V G S P GR+ ++SV V
Sbjct: 774 DEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHD 833
Query: 518 LGPGQTVSSSGPTIKPKCTVVSET-ISSKNIISRSSNGQMN 557
+ + ++ + P VV T +N++ SNG N
Sbjct: 834 V---EEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTN 871
Score = 50.4 bits (119), Expect = 5e-06
Identities = 102/461 (22%), Positives = 166/461 (36%), Gaps = 99/461 (21%)
Query: 120 DREYEMEEENEFLEYNHAESEQE---YEEEQEPPKVESKP----------KVPLKSAPPP 166
DR + E E EY ++ SE+E + EE EP + + P ++ ++
Sbjct: 307 DRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNS 366
Query: 167 MNFTDLLRLAEKKQFEP-VEIKVV----------KKSEERPMTAEELRERE--FLERKHR 213
+L +++Q +P IK + +K E R + ++ RERE L+ K +
Sbjct: 367 EALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQ 426
Query: 214 RKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEK 273
+++LE L ++ +++ K + + + HA KS ++
Sbjct: 427 QRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQ 486
Query: 274 HLALSSSKS-MPGER-----IKAGSGNSSQPS-LREGHDKPVFN-------GAGKPHSST 319
L + +PG+R G + +P+ RE ++ N KP S+
Sbjct: 487 QLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTG 546
Query: 320 SSPSVPKTS------ASRT-------------QKSAVEHK-------------------- 340
P +P+ S S+T KS V H+
Sbjct: 547 PEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQP 606
Query: 341 ----AKKSLSH-PSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVA--RPTVSS 393
A SH P + P P TP A+ +RQ +S PG A RP +
Sbjct: 607 TRNLAAFPASHDPDPAIPAPTATP--SARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEA 664
Query: 394 GPVPRRQNGSSSSGPERSISGSKKP---TNDSNPSRRTVSGTCGPGQPASSSGGPGR--- 447
P ++ S ++ S +G +P SNP R PG S S P
Sbjct: 665 PPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLR----RSDPGWERSDSVLPASHGH 720
Query: 448 -PISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGR 487
P +GS+ R SS+ PV SP +P PGR
Sbjct: 721 LPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGR 761
Score = 33.5 bits (75), Expect = 0.67
Identities = 28/110 (25%), Positives = 54/110 (49%), Gaps = 13/110 (11%)
Query: 580 GYKRQREYE----EEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESD 635
G K + EYE EE+DD + E + GE +R F +++ K S+
Sbjct: 314 GEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGEST------LRREFLRLQQENKSNSE 367
Query: 636 YALRYMESSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR 685
AL+ + ++QQ++ ++ + + + R EE++ +RRR ++ +RR
Sbjct: 368 -ALKQQQQLQQQQQRDPEAHIKHLLHQ--RQRRIEEQKEERRRVEEQQRR 414
Score = 30.4 bits (67), Expect = 5.7
Identities = 16/105 (15%), Positives = 54/105 (51%), Gaps = 2/105 (1%)
Query: 581 YKRQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRY 640
++RQR EE+ ++ + + E ++E + + ++ R++ + +++ Y
Sbjct: 392 HQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEY 451
Query: 641 MESSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR 685
+EQ++ E L+ +Q++ ++ +++ Q+++ +K +++
Sbjct: 452 KRKQLEEQRQSE--RLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQ 494
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 66.2 bits (160), Expect = 9e-11
Identities = 103/462 (22%), Positives = 176/462 (38%), Gaps = 70/462 (15%)
Query: 49 KRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKR 108
K + E LRR+ LE+++R+ E K+++ + K+ ++ + +EE+ ++
Sbjct: 362 KERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRR---------RLEEQQRRE 412
Query: 109 QATESHTSQGTDREYEMEEENEFLEYNHAESEQEY-----EEEQEPPKVESKPKVPLKSA 163
+ + R YE + E E AE EQEY EE+++ +++ + K
Sbjct: 413 KELRKQQEREQRRHYEEQMRRE-EERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYL 471
Query: 164 PPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFLERK------HRRKKL 217
+ R EKK K E+P A+E+ ER L R+ H+
Sbjct: 472 VSLQHQRQEQRPVEKKPL--YHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANR 529
Query: 218 ETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLAL 277
+D LPP + S G + ++ P +P A K P++ + +
Sbjct: 530 ISDPNLPPRSESFSIS-----GVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHE 584
Query: 278 SSSKSMPG--ERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKS 335
+K + G E + S P R+ D ++ +P +P +
Sbjct: 585 QPTKGLSGFQEALNVTSHRVEMP--RQNSD-----------PTSENPPLP---------T 622
Query: 336 AVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGP 395
+E + S P P V + SP + + S + + P G ++P +S P
Sbjct: 623 RIEKFDRSSWLRQEEDIP-PKVPQRTTSISPALARKNSPGNGSALGPRLG-SQPIRASNP 680
Query: 396 VPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSS 455
RR S +R+ SGS ++ S PS QP+S G +GS
Sbjct: 681 DLRRTEPILESPLQRTSSGSS--SSSSTPS----------SQPSSQGGSQPGSQAGSSER 728
Query: 456 ARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSIS 497
R +S+ G PV PHE P R ++ P R S
Sbjct: 729 TRVRANSKSEGSPV-LPHE---PAKVKPEESRDITRPSRPAS 766
Score = 44.3 bits (103), Expect = 4e-04
Identities = 107/534 (20%), Positives = 204/534 (38%), Gaps = 71/534 (13%)
Query: 120 DREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLR--LAE 177
DR + E + EY ++ SE+E EEE + + S +P +S D LR LA
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEE-EEENDSGEPSSILNLPGESTLR----RDFLRLQLAN 361
Query: 178 KKQFEPVEIKVVKKSE------ERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKA 231
K++ E + + +++ + +R + AE R++ E+K +R++LE + + K+
Sbjct: 362 KERSEALRRQQLEQQQRENEEHKRQLLAE--RQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
Query: 232 PSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAG 291
++ + + +R + E++ + E+ A + + ER
Sbjct: 420 EREQRRHYEEQMRREEERRRAEH-------EQEYKRKQLEEQRQAERLQRQLKQERDYLV 472
Query: 292 SGNSSQPSLREGHDKPVF------NGAGKPH-----------SSTSSPSVPKTSASRTQK 334
S + R KP++ + + KP + SSP++P A+R
Sbjct: 473 SLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISD 532
Query: 335 SAVEHKAKK-SLSHPSHSRPGPMVTPHN---------KAKSPGVRQPGSSSSSAPGQPST 384
+ +++ S+S +R PM+ P + K++ P + ++S S QP+
Sbjct: 533 PNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPAL----TASQSVHEQPTK 588
Query: 385 GVA------RPTVSSGPVPRRQNGSSSSGPERSISGSK-------KPTNDSNPSRRTVSG 431
G++ T +PR+ + +S P K + D P +
Sbjct: 589 GLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTT 648
Query: 432 TCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHE--LRRPVSGLGPPGRSV 489
+ P +S G G + + S +P+ +S R E L+R SG +
Sbjct: 649 SISPALARKNSPGNGSALGPRLGS-QPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTP 707
Query: 490 SGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPT-IKPKCTVVSETISSKNII 548
S S GS P + S+ +S G V P +KP+ + S
Sbjct: 708 SSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASY 767
Query: 549 SRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEME 602
++ + + + L R + + + T Y E E E +++E D E E
Sbjct: 768 KKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSE-ESESSEEEEEDGESE 820
Score = 33.1 bits (74), Expect = 0.88
Identities = 19/78 (24%), Positives = 41/78 (52%), Gaps = 5/78 (6%)
Query: 610 EPQEEISKHIREIFGYDRKKYKDESDYALRYMESSWKEQQ--KEEAKSLRLGMQEDLEEM 667
+ Q E +H R++ +K+ +++ + R E +E++ K++ + R +E +M
Sbjct: 375 QQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEE---QM 431
Query: 668 RREEEEMQRRRAKKLKRR 685
RREEE + ++ KR+
Sbjct: 432 RREEERRRAEHEQEYKRK 449
Score = 30.8 bits (68), Expect = 4.3
Identities = 18/102 (17%), Positives = 50/102 (49%), Gaps = 4/102 (3%)
Query: 583 RQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRYME 642
R+++ E++ +++E+ ++ + E Q+E + + E +++ K+ R
Sbjct: 369 RRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEE----QQRREKELRKQQEREQR 424
Query: 643 SSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKR 684
++EQ + E + R +++ + + EE+ R ++LK+
Sbjct: 425 RHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQ 466
>gi|41281612 zinc finger protein 828 [Homo sapiens]
Length = 812
Score = 65.9 bits (159), Expect = 1e-10
Identities = 114/470 (24%), Positives = 172/470 (36%), Gaps = 38/470 (8%)
Query: 134 YNHAESEQEYEEE--QEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKK 191
Y H S+ ++ +P +K P+KS P P + AE K + ++ K
Sbjct: 78 YYHITSKHASPDKWNDKPKNQLNKETDPVKSPPLPEHQKIPCNSAEPKSIPALSMETQKL 137
Query: 192 SEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHP 251
++ E + + ++ +L + PS+ SV + S
Sbjct: 138 GSV--LSPESPKPTPLTPLEPQKPGSVVSPELQTPLPSPEPSKPASVSSPEPPKSVPVCE 195
Query: 252 SSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNG 311
S K P+P E + ++ E ++ ++ S P + ++ + P + PV
Sbjct: 196 SQKLAPVPSPEPQKPAPVSPE---SVKATLSNPKPQKQSHFPETLGPPSASSPESPVL-- 250
Query: 312 AGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQP 371
A P SP+ S + ++ E + P +P P V+P + +P V P
Sbjct: 251 AASPEPWGPSPAASPESRKSARTTSPEPRKPSPSESPEPWKPFPAVSPEPRRPAPAV-SP 309
Query: 372 GSSSSSAPGQPSTGVARPTVSSGP-VPRRQNGSSSSGPERSI----SGSKKPTNDSNPSR 426
GS PG P + P+ SSGP P + S S GP + I G KPT PS
Sbjct: 310 GSWKPGPPGSPRPWKSNPSASSGPWKPAKPAPSVSPGPWKPIPSVSPGPWKPT----PSV 365
Query: 427 RTVSGTCGPGQPASSSGGPGRPISGSV------SSARPLGSSRGPGRPVSSPHELRRPVS 480
+ S P+S P P S +A L P SP ELR+P
Sbjct: 366 SSASWKSSSVSPSSWKSPPASPESWKSGPPELRKTAPTLSPEHWKAVPPVSP-ELRKPGP 424
Query: 481 GLGPPGRSVSGPG--RSISGS------IPAGRTVSNS---VPGRPVSSLGPGQTVSSSGP 529
L P RS +G R SGS P R S + P SS G + S
Sbjct: 425 PLSPEIRSPAGSPELRKPSGSPDLWKLSPDQRKTSPASLDFPESQKSSRGGSPDLWKSSF 484
Query: 530 TIKPKCTVVSETIS-SKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFP 578
I+P+ V ET + S S + KP LS + P P P
Sbjct: 485 FIEPQKPVFPETRKPGPSGPSESPKAASDIWKPVLSIDTEPRKPALFPEP 534
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 65.5 bits (158), Expect = 2e-10
Identities = 102/459 (22%), Positives = 175/459 (38%), Gaps = 70/459 (15%)
Query: 49 KRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKR 108
K + E LRR+ LE+++R+ E K+++ + K+ ++ + +EE+ ++
Sbjct: 362 KERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRR---------RLEEQQRRE 412
Query: 109 QATESHTSQGTDREYEMEEENEFLEYNHAESEQEY-----EEEQEPPKVESKPKVPLKSA 163
+ + R YE + E E AE EQEY EE+++ +++ + K
Sbjct: 413 KELRKQQEREQRRHYEEQMRRE-EERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYL 471
Query: 164 PPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFLERK------HRRKKL 217
+ R EKK K E+P A+E+ ER L R+ H+
Sbjct: 472 VSLQHQRQEQRPVEKKPL--YHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANR 529
Query: 218 ETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLAL 277
+D LPP + S G + ++ P +P A K P++ + +
Sbjct: 530 ISDPNLPPRSESFSIS-----GVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHE 584
Query: 278 SSSKSMPG--ERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKS 335
+K + G E + S P R+ D ++ +P +P +
Sbjct: 585 QPTKGLSGFQEALNVTSHRVEMP--RQNSD-----------PTSENPPLP---------T 622
Query: 336 AVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGP 395
+E + S P P V + SP + + S + + P G ++P +S P
Sbjct: 623 RIEKFDRSSWLRQEEDIP-PKVPQRTTSISPALARKNSPGNGSALGPRLG-SQPIRASNP 680
Query: 396 VPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSS 455
RR S +R+ SGS ++ S PS QP+S G +GS
Sbjct: 681 DLRRTEPILESPLQRTSSGSS--SSSSTPS----------SQPSSQGGSQPGSQAGSSER 728
Query: 456 ARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGR 494
R +S+ G PV PHE P R ++ P R
Sbjct: 729 TRVRANSKSEGSPV-LPHE---PAKVKPEESRDITRPSR 763
Score = 47.4 bits (111), Expect = 4e-05
Identities = 109/534 (20%), Positives = 204/534 (38%), Gaps = 79/534 (14%)
Query: 120 DREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLR--LAE 177
DR + E + EY ++ SE+E EEE + + S +P +S D LR LA
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEE-EEENDSGEPSSILNLPGESTLR----RDFLRLQLAN 361
Query: 178 KKQFEPVEIKVVKKSE------ERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKA 231
K++ E + + +++ + +R + AE R++ E+K +R++LE + + K+
Sbjct: 362 KERSEALRRQQLEQQQRENEEHKRQLLAE--RQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
Query: 232 PSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAG 291
++ + + +R + E++ + E+ A + + ER
Sbjct: 420 EREQRRHYEEQMRREEERRRAEH-------EQEYKRKQLEEQRQAERLQRQLKQERDYLV 472
Query: 292 SGNSSQPSLREGHDKPVF------NGAGKPH-----------SSTSSPSVPKTSASRTQK 334
S + R KP++ + + KP + SSP++P A+R
Sbjct: 473 SLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISD 532
Query: 335 SAVEHKAKK-SLSHPSHSRPGPMVTPHN---------KAKSPGVRQPGSSSSSAPGQPST 384
+ +++ S+S +R PM+ P + K++ P + ++S S QP+
Sbjct: 533 PNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPAL----TASQSVHEQPTK 588
Query: 385 GVA------RPTVSSGPVPRRQNGSSSSGPERSISGSK-------KPTNDSNPSRRTVSG 431
G++ T +PR+ + +S P K + D P +
Sbjct: 589 GLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTT 648
Query: 432 TCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHE--LRRPVSGLGPPGRSV 489
+ P +S G G + + S +P+ +S R E L+R SG +
Sbjct: 649 SISPALARKNSPGNGSALGPRLGS-QPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTP 707
Query: 490 SGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPT-IKPKCTVVSETISSKNII 548
S S GS P + S+ +S G V P +KP+ S++I
Sbjct: 708 SSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPE--------ESRDIT 759
Query: 549 SRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEME 602
S + + L R + + + T Y E E E +++E D E E
Sbjct: 760 RPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSE-ESESSEEEEEDGESE 812
Score = 33.1 bits (74), Expect = 0.88
Identities = 19/78 (24%), Positives = 41/78 (52%), Gaps = 5/78 (6%)
Query: 610 EPQEEISKHIREIFGYDRKKYKDESDYALRYMESSWKEQQ--KEEAKSLRLGMQEDLEEM 667
+ Q E +H R++ +K+ +++ + R E +E++ K++ + R +E +M
Sbjct: 375 QQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEE---QM 431
Query: 668 RREEEEMQRRRAKKLKRR 685
RREEE + ++ KR+
Sbjct: 432 RREEERRRAEHEQEYKRK 449
Score = 30.8 bits (68), Expect = 4.3
Identities = 18/102 (17%), Positives = 50/102 (49%), Gaps = 4/102 (3%)
Query: 583 RQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRYME 642
R+++ E++ +++E+ ++ + E Q+E + + E +++ K+ R
Sbjct: 369 RRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEE----QQRREKELRKQQEREQR 424
Query: 643 SSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKR 684
++EQ + E + R +++ + + EE+ R ++LK+
Sbjct: 425 RHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQ 466
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 64.3 bits (155), Expect = 4e-10
Identities = 105/505 (20%), Positives = 183/505 (36%), Gaps = 100/505 (19%)
Query: 4 REILMIASKGQGVNNVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELRRKALEEK 63
RE L + + + + K+ ++DP+ ++ Q + +E++ R+ +EE+
Sbjct: 353 REFLRLQQENKSNSEALKQQQQLQQQQQRDPEAH-IKHLLHQRQRRIEEQKEERRRVEEQ 411
Query: 64 RRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQATESHTSQGTDREY 123
+R+E +K E + ++ M ++ E++ K++Q E S+ R
Sbjct: 412 QRREREQRKLQEKEQQRRLEDMQALRREEER--RQAEREQEYKRKQLEEQRQSERLQR-- 467
Query: 124 EMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEP 183
++++E+ +L+ + +Q+ ++Q+ ++ + PL MN D
Sbjct: 468 QLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPAD------------ 515
Query: 184 VEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLS 243
+P A E+ ER + ++ + +P K G+
Sbjct: 516 -----------KPAWAREVEERTRMNKQ-----------------QNSPLAKSKPGS--- 544
Query: 244 KGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREG 303
+G P + P P P M KS+
Sbjct: 545 --TGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSL-------------------- 582
Query: 304 HDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGP------MV 357
D+P N A P S P++P +A+ + + AV + S P+ PGP V
Sbjct: 583 QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAV----IRQNSDPTSEGPGPSPNPPAWV 638
Query: 358 TPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKK 417
P N+A P V Q SS ++A G +RP + PR + R+ G+ K
Sbjct: 639 RPDNEA-PPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPK 697
Query: 418 PTN-----------DSNPSRRTVSGTCGPGQPASSSGGPGR----PISGSVSSARPLGSS 462
P SNP R PG S S P P +GS+ R SS
Sbjct: 698 PPGPPAQPPGPPNASSNPDLR----RSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSS 753
Query: 463 RGPGRPVSSPHELRRPVSGLGPPGR 487
+ PV SP +P PGR
Sbjct: 754 KPDSSPVLSPGNKAKPDDHRSRPGR 778
Score = 52.0 bits (123), Expect = 2e-06
Identities = 102/473 (21%), Positives = 169/473 (35%), Gaps = 69/473 (14%)
Query: 120 DREYEMEEENEFLEYNHAESEQE---YEEEQEPPKVESKP----------KVPLKSAPPP 166
DR + E E EY ++ SE+E + EE EP + + P ++ ++
Sbjct: 307 DRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNS 366
Query: 167 MNFTDLLRLAEKKQFEP-VEIKVV----------KKSEERPMTAEELRERE--FLERKHR 213
+L +++Q +P IK + +K E R + ++ RERE L+ K +
Sbjct: 367 EALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQ 426
Query: 214 RKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEK 273
+++LE L ++ +++ K + + + HA KS ++
Sbjct: 427 QRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQ 486
Query: 274 HLALSSSKS-MPGER-----IKAGSGNSSQPS-LREGHDKPVFN-------GAGKPHSST 319
L + +PG+R G + +P+ RE ++ N KP S+
Sbjct: 487 QLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTG 546
Query: 320 SSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAP 379
P +P+ S S + P P PH + R + +S
Sbjct: 547 PEPPIPQASPG--------PPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHD 598
Query: 380 GQPSTGVARPTVSSGPVPRRQNGSSSS---GPERSISGSKKPTNDSNP-------SRRTV 429
P+ T S+ RQN +S GP + +P N++ P S T
Sbjct: 599 PDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATA 658
Query: 430 SGTCGPGQPASSSGGPGRPISGSV-SSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRS 488
T G G + RP S S + RG +P P + P + P
Sbjct: 659 LNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLR 718
Query: 489 VSGPG--RSIS------GSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKP 533
S PG RS S G +P ++ + G VSS V S G KP
Sbjct: 719 RSDPGWERSDSVLPASHGHLPQAGSLERNRVG--VSSKPDSSPVLSPGNKAKP 769
Score = 33.5 bits (75), Expect = 0.67
Identities = 28/110 (25%), Positives = 54/110 (49%), Gaps = 13/110 (11%)
Query: 580 GYKRQREYE----EEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESD 635
G K + EYE EE+DD + E + GE +R F +++ K S+
Sbjct: 314 GEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGEST------LRREFLRLQQENKSNSE 367
Query: 636 YALRYMESSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR 685
AL+ + ++QQ++ ++ + + + R EE++ +RRR ++ +RR
Sbjct: 368 -ALKQQQQLQQQQQRDPEAHIKHLLHQ--RQRRIEEQKEERRRVEEQQRR 414
Score = 32.7 bits (73), Expect = 1.1
Identities = 88/421 (20%), Positives = 142/421 (33%), Gaps = 73/421 (17%)
Query: 51 KEEELRRKALEEKRRKEELVK----------------KRIELKHDKKARAMAKRTKDNFH 94
+E+E +RK LEE+R+ E L + ++ +L+ ++ + + K +H
Sbjct: 447 REQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYH 506
Query: 95 GYNGIPIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQEP-PKVE 153
G+ +K + E T +++N L A+S+ + P P+
Sbjct: 507 YGRGMNPADKPAWAREVEERTRMN-------KQQNSPL----AKSKPGSTGPEPPIPQAS 555
Query: 154 SKPKVPLKSAPPPMNFTDLLRLAEKK-QFEPVEIKVVKKSEERPMTA-----EELREREF 207
P PL PP + K Q +P + P A R
Sbjct: 556 PGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGA 615
Query: 208 LERKHRRKKLETDGKLP---------PTVSKKAPSQKESVGTKL-SKGSGDRHPSSKGMP 257
+ R++ E G P K P + S+ T L + G+G P+
Sbjct: 616 VIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA 675
Query: 258 LPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGN-SSQPSLREGHDKPVFNGAGKPH 316
P + + + P + G N SS P LR P
Sbjct: 676 RPRSNSAWQIYLQRRAERGTPKPPGPPAQ--PPGPPNASSNPDLRR----------SDPG 723
Query: 317 SSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSS 376
S +P + Q ++E S P S P+++P NKAK R
Sbjct: 724 WERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSS---PVLSPGNKAKPDDHR------- 773
Query: 377 SAPGQPSTGV--ARPTVSSGP-VPRRQNGSSSSGPERSISGSKKPTNDSNP---SRRTVS 430
S PG+P+ V T+ P P++ SSS E S + + P SR T
Sbjct: 774 SRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPG 833
Query: 431 G 431
G
Sbjct: 834 G 834
Score = 30.4 bits (67), Expect = 5.7
Identities = 16/105 (15%), Positives = 54/105 (51%), Gaps = 2/105 (1%)
Query: 581 YKRQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRY 640
++RQR EE+ ++ + + E ++E + + ++ R++ + +++ Y
Sbjct: 392 HQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEY 451
Query: 641 MESSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR 685
+EQ++ E L+ +Q++ ++ +++ Q+++ +K +++
Sbjct: 452 KRKQLEEQRQSE--RLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQ 494
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 62.8 bits (151), Expect = 1e-09
Identities = 140/578 (24%), Positives = 213/578 (36%), Gaps = 115/578 (19%)
Query: 12 KGQGVNN-VPKRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELRR-KALEEKRRKEEL 69
+G G N V + SL G + P KG EEELRR +A KR ++
Sbjct: 11 RGSGTNGYVQRNLSLVRGRRGERPDYKG-------------EEELRRLEAALVKRPNPDI 57
Query: 70 V----KKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEK--SKKRQATESHTSQGTDREY 123
+ K+R+EL+ + M ++ GY I+EK + + E + G E
Sbjct: 58 LDHERKRRVELRCLELEEMMEEQ------GYEEQQIQEKVATFRLMLLEKDVNPGGKEET 111
Query: 124 E-----MEEENEFLEYNHAESEQ---------EYEEEQ--EPPKVESKPKVPLKSAPPPM 167
+ E ++ E N ++E+ Y + +P + + K P P P
Sbjct: 112 PGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPY 171
Query: 168 NFTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTV 227
+ L+R + + + K KK ++R +E R ++ ++KK ++ +
Sbjct: 172 S---LVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESE----- 223
Query: 228 SKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGER 287
SKK + + +K R S P P + + R + A+ A SS S R
Sbjct: 224 SKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADS---ASSSDTSRSRSR 280
Query: 288 IKAG-------SGNSSQP-SLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEH 339
A +G S P S R G F+ G +ST PS P+T A++ S E
Sbjct: 281 SAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGT--TSTQRPSSPET-ATKQPSSPYED 337
Query: 340 KAK----KSLSHPSHS-----------------------RPGPMVT---------PHNKA 363
K K KS + PS S P P+ T P ++A
Sbjct: 338 KDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEA 397
Query: 364 KSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSN 423
R P S P S+ + P+ P P + + +SS PE S KP +
Sbjct: 398 SPTRDRSPPKSPEKLPQSSSSESSPPS----PQPTKVSRHASSSPE-----SPKPA-PAP 447
Query: 424 PSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLG 483
S R +S + P S G R S S + +R +G SR P R P
Sbjct: 448 GSHREISSS--PTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTK--R 503
Query: 484 PPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPG 521
RS S R + GR+ S GR S PG
Sbjct: 504 GHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPG 541
Score = 58.2 bits (139), Expect = 3e-08
Identities = 56/210 (26%), Positives = 80/210 (38%), Gaps = 16/210 (7%)
Query: 224 PPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSM 283
P + + S S + S S SS G +E S P + S
Sbjct: 2526 PAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPA 2585
Query: 284 PGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKK 343
P E ++ G P+ R+ + + SS+SS S +S+S + S+ +
Sbjct: 2586 PKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2645
Query: 344 SLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTG-----------VARPTVS 392
S S PS ++PGP P K SP PG S +P +P V R S
Sbjct: 2646 S-SSPSPAKPGPQALP--KPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPS 2702
Query: 393 SGPVPRRQNGSSSS-GPERSISG-SKKPTN 420
P PR Q SSS G R G S+ P++
Sbjct: 2703 PQPSPRDQQSSSSERGSRRGQRGDSRSPSH 2732
Score = 57.4 bits (137), Expect = 4e-08
Identities = 107/451 (23%), Positives = 154/451 (34%), Gaps = 74/451 (16%)
Query: 138 ESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEER-- 195
+ ++E + P E P AP P+ LAE+ P + S+E
Sbjct: 340 KDKKEKSATRPSPSPERSSTGPEPPAPTPL-------LAERHGGSPQPLATTPLSQEPVN 392
Query: 196 -PMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSK 254
P A R+R ++ KLP + S ++ S TK+S+ + S K
Sbjct: 393 PPSEASPTRDRS---------PPKSPEKLPQSSSSES-SPPSPQPTKVSRHASSSPESPK 442
Query: 255 GMPLP--HAEKKSRPSMANEKHLALSSSKS---MPGERI--------------------K 289
P P H E S P+ N H KS P R+ K
Sbjct: 443 PAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTK 502
Query: 290 AGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPS 349
G S P R + + P S S + SR++ + +++ + S
Sbjct: 503 RGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRS 562
Query: 350 HSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTV--SSGPVPRRQNGSSSSG 407
HSR P +++++P R G S S P + + PT S P R+ S S
Sbjct: 563 HSR-SPATRGRSRSRTPARR--GRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRT 619
Query: 408 PERSISGSKKP----------------TNDSNPSRRTVSGTCGPGQPASSSGGPGRPISG 451
P R S ++ P + P+RR S + P + S SG
Sbjct: 620 PARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSG 679
Query: 452 SVSSARPL----GSSRGPGRPVSSPHEL-RRPVSGLGPP---GRSVSGPGRSISGSIPAG 503
S P SR P R S L RR S P GRS S R
Sbjct: 680 RSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQR 739
Query: 504 RTVSNSVPGRPVSSLGPGQTVSSSGPTIKPK 534
R+ SNS P S + ++ S S P K K
Sbjct: 740 RSRSNSSPEMKKSRISSRRSRSLSSPRSKAK 770
Score = 57.0 bits (136), Expect = 6e-08
Identities = 96/398 (24%), Positives = 144/398 (36%), Gaps = 60/398 (15%)
Query: 190 KKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDR 249
++S R T R R R R + + + S+ S + + S R
Sbjct: 592 RRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGR-SRSR 650
Query: 250 HPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVF 309
P+ +G + +R + + A S +S + G S P + +
Sbjct: 651 TPARRGRS--RSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLV 708
Query: 310 NGAGKPHSSTSSPSVPKTSAS-RTQKSAVEHKAKKSLSHP-------SHSRPGPMVTPHN 361
G+ HS T S+S R KS + +S S P S R + +P +
Sbjct: 709 R-RGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRS 767
Query: 362 KAKSP-GVRQPGSSSSSAPGQPS--------TGVARPTVSSGPVPRRQNGSSSSGPERSI 412
KAKS +R+ S SS P Q S +G ++P S PRR SSS P++
Sbjct: 768 KAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQK- 826
Query: 413 SGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSP 472
SK P+ S+ S P SG P P GS++S + S P R S
Sbjct: 827 --SKTPSRQSHSS--------SSPHPKVKSGTP--PRQGSITSPQANEQSVTPQR--RSC 872
Query: 473 HELRRPVSGLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVS-SSGPTI 531
E S P + P+ + S S P R SS P Q+ S SS P
Sbjct: 873 FE---------------SSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQP 917
Query: 532 KPKCTVV--------SETISSKNIISRSSNGQMNGMKP 561
K K + S + S + SR++ + + P
Sbjct: 918 KVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSP 955
Score = 53.1 bits (126), Expect = 8e-07
Identities = 108/472 (22%), Positives = 172/472 (36%), Gaps = 78/472 (16%)
Query: 79 DKKARAMAKRTKDNFHGYNGIPIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHAE 138
D K+R +R++ +G E K K R A + + + E + + +
Sbjct: 1586 DSKSRLSPRRSR------SGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSG 1639
Query: 139 SEQEYE--EEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERP 196
S + + ES P+ P KS R + EP
Sbjct: 1640 SSSKGRGPSPEGSSSTESSPEHPPKSRTA--------RRGSRSSPEPKTKSRTPPRRRSS 1691
Query: 197 MTAEELREREFLERKHRRKKL--ETDGKLPP------TVSKKAPSQKE----------SV 238
++ EL + L R+ R ET + PP +VS P++K S
Sbjct: 1692 RSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSP 1751
Query: 239 GTKLSKGSGDRHPSSKGMPLPHAEKKSR--------------PSMANEKHLALSSSKSMP 284
TK + G R PS K L + +SR S + + S S+S
Sbjct: 1752 RTKTTSRRG-RSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRV 1810
Query: 285 GERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKS 344
R + GSG S+ R+ + + + S + P+ K S SRT + +
Sbjct: 1811 TRRRRGGSGYHSRSPARQESSRT--SSRRRRGRSRTPPTSRKRSRSRTSPAPWKR----- 1863
Query: 345 LSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVS-------SGPVP 397
S SR P +++++P + + S S ++P +R +V+ + PV
Sbjct: 1864 ----SRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVS 1919
Query: 398 RRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSAR 457
RR++ S + R S S+ PT RR+ S T + S S P P++ S +R
Sbjct: 1920 RRRSRSRTPPVTRRRSRSRTPTT----RRRSRSRTPPVTRRRSRSRTP--PVTRRRSRSR 1973
Query: 458 PLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSISGSIPAGRTVSNS 509
+R R +SP RR S P R RS S + P R S S
Sbjct: 1974 TSPITRRRSRSRTSPVTRRRSRSRTSPVTRR-----RSRSRTSPVTRRRSRS 2020
Score = 51.6 bits (122), Expect = 2e-06
Identities = 79/306 (25%), Positives = 113/306 (36%), Gaps = 37/306 (12%)
Query: 210 RKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSM 269
++ R ++ K S++ S K S+ S R S+ + P ++ KSR S+
Sbjct: 719 QRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRR---SRSLSSPRSKAKSRLSL 775
Query: 270 ANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVP---- 325
+LS S P ++ + S R G +P P S SS S P
Sbjct: 776 RR----SLSGSSPCPKQKSQTPPRRS-----RSGSSQPKAKSRTPPRRSRSSSSPPPKQK 826
Query: 326 -KTSASRTQKSAVEHKAKKSLSHPSH-SRPGPM-----VTPHNKAKSPGVRQPGSSSSSA 378
KT + ++ S+ H KS + P S P VTP ++ P S +
Sbjct: 827 SKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTP 886
Query: 379 PGQPSTGVARPTVSSGPVPRRQNGSSSSGPE-----------RSISGSKKPTNDSNPSRR 427
+G + P V S P RQ+ S SS P+ RS SGS P+ SR
Sbjct: 887 SRHSCSGSSPPRVKSS-TPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRT 945
Query: 428 TV--SGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPP 485
T S + P S P SGS S + P + S V PP
Sbjct: 946 TPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPP 1005
Query: 486 GRSVSG 491
G S+SG
Sbjct: 1006 GPSLSG 1011
Score = 51.2 bits (121), Expect = 3e-06
Identities = 77/307 (25%), Positives = 112/307 (36%), Gaps = 50/307 (16%)
Query: 228 SKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHA-EKKSRPSMANEKHLALSSSKSMPGE 286
S++APS +G S+ P+P A +SR +A +A S S S
Sbjct: 2421 SERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLS---- 2476
Query: 287 RIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKK--- 343
+G+ ++ S + + G PHS P T A + A AK+
Sbjct: 2477 ---SGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPA-STGAQQPSALAALQPAKERRS 2532
Query: 344 -SLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVAR---PT------VSS 393
S S S S + + + S G S SS P QP + R PT V
Sbjct: 2533 SSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVRE 2592
Query: 394 GPVP-------RRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPG 446
G P +R++ SSSS S S S ++ S+ S + S + +SSS P
Sbjct: 2593 GRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPA 2652
Query: 447 RPISGSVSSARPLG---------SSRGPGRPVS----------SPHELRRPVSGLGPPGR 487
+P G + +P SR P +P+ SP E RRP P +
Sbjct: 2653 KP--GPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQ 2710
Query: 488 SVSGPGR 494
S R
Sbjct: 2711 QSSSSER 2717
Score = 49.7 bits (117), Expect = 9e-06
Identities = 53/226 (23%), Positives = 86/226 (38%), Gaps = 37/226 (16%)
Query: 227 VSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGE 286
+S AP S + +G + PS+ P E++S S ++ + SSS S
Sbjct: 2494 LSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSS 2553
Query: 287 RIKAGSGNSSQPS-----------------------LREGHD-----------KPVFNGA 312
S + S+ S +REG + +
Sbjct: 2554 SSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSS 2613
Query: 313 GKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPG 372
SS+SS S +S+S + S+ + S S PS ++PGP P K SP PG
Sbjct: 2614 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALP--KPASPKKPPPG 2671
Query: 373 SSSSSAPGQPSTGVA-RPTVSSGPVPRRQNGSSSSGPERSISGSKK 417
S +P +P + ++S PV RR+ S ++ S S++
Sbjct: 2672 ERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSER 2717
Score = 48.1 bits (113), Expect = 3e-05
Identities = 100/442 (22%), Positives = 144/442 (32%), Gaps = 64/442 (14%)
Query: 150 PKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEP-VEIKVVKKSEERPMTAEELREREFL 208
P+ S+ + S+P P R + P + K + ER + + ++
Sbjct: 1470 PRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVA 1529
Query: 209 -----ERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEK 263
+R E D K P+ S + S+ +S +K S+ P +
Sbjct: 1530 RTPLGQRSRSGSSQELDVK--PSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDS 1587
Query: 264 KSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPS 323
KSR S + + K P +A SG+ S P
Sbjct: 1588 KSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPE------------------------ 1623
Query: 324 VPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPS 383
PK A R + P SR G +K + P S+ SS P
Sbjct: 1624 -PKAPAPR--------------ALPRRSRSG----SSSKGRGPSPEGSSSTESSPEHPPK 1664
Query: 384 TGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSG 443
+ AR S P P+ + S + RS S + T + SRR+ S + P S
Sbjct: 1665 SRTARRGSRSSPEPKTK--SRTPPRRRSSRSSPELTRKARLSRRSRSASSSP--ETRSRT 1720
Query: 444 GPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSISGSIPAG 503
P S SVSS P SR R S+ + S GRS S R + S
Sbjct: 1721 PPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTS---RRGRSPSPKPRGLQRSRSRS 1777
Query: 504 RTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSETISSKNIISRSSNGQMNGMKPPL 563
R R S G Q+ S + + V SRS Q +
Sbjct: 1778 RREKTRTTRRRDRS-GSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSR---- 1832
Query: 564 SGYRAAQGPQRLPFPTGYKRQR 585
+ R +G R P PT KR R
Sbjct: 1833 TSSRRRRGRSRTP-PTSRKRSR 1853
Score = 48.1 bits (113), Expect = 3e-05
Identities = 108/522 (20%), Positives = 182/522 (34%), Gaps = 75/522 (14%)
Query: 21 KRYSLAVGPPKKDPKVKGVQSAAVQAFLKRKEEELRRKALEEKRRKEELVKKRIELKHDK 80
+R A P K +G + L+R RR+ RR++ + + +
Sbjct: 1743 RRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQ 1802
Query: 81 KARAMAKRTKDNFHG---YNGIPIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHA 137
++R+ ++ T+ G ++ P ++S + T S +G R + + A
Sbjct: 1803 RSRSRSRVTRRRRGGSGYHSRSPARQESSR---TSSRRRRGRSRTPPTSRKRSRSRTSPA 1859
Query: 138 ESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPM 197
++ S+ + PL S R + + PV S R
Sbjct: 1860 PWKRSRSRASPATHRRSRSRTPLIS-----------RRRSRSRTSPV-------SRRRSR 1901
Query: 198 TAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMP 257
+ + R R + + + PP +++ S+ + R S+ P
Sbjct: 1902 SRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTR---------RRSRSRTPP 1952
Query: 258 LPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHS 317
+ +SR + S S++ P R ++ S S R
Sbjct: 1953 VTRRRSRSRTPPVTRRR---SRSRTSPITRRRSRSRTSPVTRRRS--------------R 1995
Query: 318 STSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQP-GSSSS 376
S +SP + S SRT S V + +S + P+ R TP K R P
Sbjct: 1996 SRTSPVTRRRSRSRT--SPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRR 2053
Query: 377 SAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPG 436
S P T + +++ P R+ +S S +RS S + P+ R SG+ P
Sbjct: 2054 SRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATP-------PATRNHSGSRTP- 2105
Query: 437 QPASSSGGPGRPISGSVSSARPLGSSRGPG--RPVSSPHELRRPVSGLGPPGRS-VSGPG 493
P + + S S PL R PG P+ S R P+S L G S + GPG
Sbjct: 2106 -PVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSS---RTPMSVLQQAGGSMMDGPG 2161
Query: 494 RSISG----SIPAGRTVSNSVPGRPVSSLG---PGQTVSSSG 528
I S+P S SLG P ++S++G
Sbjct: 2162 PRIPDHQRTSVPENHAQSRIALALTAISLGTARPPPSMSAAG 2203
Score = 47.4 bits (111), Expect = 4e-05
Identities = 78/363 (21%), Positives = 120/363 (33%), Gaps = 47/363 (12%)
Query: 250 HPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVF 309
+PSS P + + ++ + ++ ++ G R A +S S R P
Sbjct: 2323 YPSSSRTP----QAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMA---PAL 2375
Query: 310 NGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVR 369
+GA + +SP VP ++ R V + L + SR P ++ S
Sbjct: 2376 SGA-----NLTSPRVPLSAYER-----VSGRTSPPLLDRARSRTPPSAPSQSRMTSERAP 2425
Query: 370 QPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSS---------SGPERSISGSKKPTN 420
P S AP Q A+ S PVP + S +G + SG+ T
Sbjct: 2426 SPSSRMGQAPSQSLLPPAQDQPRS-PVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTT 2484
Query: 421 DSNPSRRTVSGTCGPGQPASSSGGP----GRPISGSVSSARPLGSSRGPGRPVSSPHELR 476
S + PG P S G P G ++++ +P R SS
Sbjct: 2485 SSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSS 2544
Query: 477 RPVSGLGPPGRSVSGPGRSISGSIPAG----------------RTVSNSVPGRPVSSLGP 520
S S S S S+P V P P +
Sbjct: 2545 SSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRK 2604
Query: 521 GQTVSSSGPTIKPKCTVVSETISSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTG 580
++ SSS + + S + SS + S SS+ + S A GPQ LP P
Sbjct: 2605 RRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPAS 2664
Query: 581 YKR 583
K+
Sbjct: 2665 PKK 2667
Score = 42.0 bits (97), Expect = 0.002
Identities = 99/441 (22%), Positives = 150/441 (34%), Gaps = 79/441 (17%)
Query: 120 DREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPP--MNFTDLLRLAE 177
D E + E LE EQ YEE+Q KV + + L+ P T R A
Sbjct: 59 DHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEETPGQRPAV 118
Query: 178 KKQFEPVEIKVVKKSEERPM--TAEELREREFLERKHRRKKLETDGKLPP--------TV 227
+ + E+ K R ++ + + + R ++ + PP +
Sbjct: 119 TETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESS 178
Query: 228 SKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSM---- 283
S ++P+ K+ K K G R SS P E+K S +KH + S SK
Sbjct: 179 SSRSPTPKQKKKKK-KKDRGRRSESSS----PRRERKK--SSKKKKHRSESESKKRKHRS 231
Query: 284 PGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKK 343
P + K S + + R P A H STS+ S + SR++ + AK
Sbjct: 232 PTPKSKRKSKDKKRKRSRSTTPAPKSRRA---HRSTSADSASSSDTSRSRSRSAA--AKT 286
Query: 344 SLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGS 403
+ + P P + +P +PG++S+ P P T +P+
Sbjct: 287 HTTALAGRSPSPASGRRGEGDAP-FSEPGTTSTQRPSSPETATKQPS------------- 332
Query: 404 SSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSR 463
P D + ++ S T RP S P SS
Sbjct: 333 -------------SPYEDKDKDKKEKSAT--------------RP------SPSPERSST 359
Query: 464 GPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQT 523
GP P +P R G P + ++ A T S P P P +
Sbjct: 360 GPEPPAPTPLLAERH-GGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKL--PQSS 416
Query: 524 VSSSGPTIKPKCTVVSETISS 544
S S P P+ T VS SS
Sbjct: 417 SSESSPP-SPQPTKVSRHASS 436
Score = 42.0 bits (97), Expect = 0.002
Identities = 74/330 (22%), Positives = 110/330 (33%), Gaps = 79/330 (23%)
Query: 214 RKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEK 273
+ K T + + S P QK ++ S S HP K P + P ANE+
Sbjct: 805 KAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQ-ANEQ 863
Query: 274 HLA---LSSSKSMPGERIKAG-------SGNS--------------SQPSLREGHDKPVF 309
+ S +S P +K+ SG+S S+ S + K +
Sbjct: 864 SVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAII 923
Query: 310 NGAGKPHSSTSSPS--------VPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHN 361
+ + HS +SSPS P+ S S + S VE + SH S P V P
Sbjct: 924 SPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPET 983
Query: 362 ----------------KAKSP------GVRQP----------------------GSSSSS 377
KA++P G + P G SS+
Sbjct: 984 PPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSST 1043
Query: 378 APGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQ 437
PG+ GV+ + + S +S PE S S+ P+ S G
Sbjct: 1044 PPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSS 1103
Query: 438 PAS--SSGGPGRPISGSVSSARPLGSSRGP 465
P + +S P R G S++ L S P
Sbjct: 1104 PVTELASRSPIRQDRGEFSASPMLKSGMSP 1133
Score = 36.6 bits (83), Expect = 0.079
Identities = 42/183 (22%), Positives = 65/183 (35%), Gaps = 6/183 (3%)
Query: 224 PPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSM 283
P K+ PS + + +G P+ + S S ++ + SSS S
Sbjct: 2572 PEVALKRVPSPTPAPKEAVREGRPPE-PTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSS 2630
Query: 284 PGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEH-KAK 342
+ S +SS S KP KP S P P SR+ + ++ +
Sbjct: 2631 SSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPP--PGERRSRSPRKPIDSLRDS 2688
Query: 343 KSLSHP--SHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQ 400
+SLS+ RP P +P ++ S R PS R T S P+ R
Sbjct: 2689 RSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRS 2748
Query: 401 NGS 403
+ S
Sbjct: 2749 SRS 2751
Score = 33.9 bits (76), Expect = 0.51
Identities = 99/464 (21%), Positives = 161/464 (34%), Gaps = 50/464 (10%)
Query: 96 YNGIPIEEKSKKRQATESHTSQGTDREY-EMEEENEFLEYNHAESEQEYEEEQEPPKVES 154
Y G+ + + Q + H S + E + E+ L+ S + P E
Sbjct: 1049 YFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTEL 1108
Query: 155 KPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERP-MTAEELREREFLERKHR 213
+ P++ + + +L K P + + S P + + L + LE
Sbjct: 1109 ASRSPIRQDRGEFSASPML----KSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAES 1164
Query: 214 RKKLETDGKLPPTVSKKA--PSQKESVGTKLSKGSGDRHPSSK-----GMPLPHAEKKSR 266
++K+ LPP A P QK+ K S P S + P E+
Sbjct: 1165 KEKMA----LPPQEDATASPPRQKD----KFSPFPVQDRPESSLVFKDTLRTPPRERSGA 1216
Query: 267 PSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSST---SSPS 323
S K + S E + S +P+ G + K S++ SSP
Sbjct: 1217 GSSPETKEQNSALPTSSQDEELMEVVEKSEEPA---GQILSHLSSELKEMSTSNFESSPE 1273
Query: 324 VPKTSA-SRTQKSAVEHKAKKSLSHPS--HSRPGPMVTPHNKAKSPGVRQPGSSSSSAPG 380
V + A S T + + +++ PS S GP +P +K S+S
Sbjct: 1274 VEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHK----------ELSNSPLR 1323
Query: 381 QPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPAS 440
+ S G +SGP+ N SS + ++G +++PS + +S
Sbjct: 1324 ENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSS 1383
Query: 441 SSGGPGRPISGSVSSARPLGSS------RGPGRPVSSPHELRRPVSGLG--PPGRSVSG- 491
S P +SS + + S R P R SS GL P RS SG
Sbjct: 1384 SELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGS 1443
Query: 492 -PGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPK 534
PG P+ ++S S PG P + S + +PK
Sbjct: 1444 SPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPK 1487
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 62.4 bits (150), Expect = 1e-09
Identities = 103/479 (21%), Positives = 191/479 (39%), Gaps = 75/479 (15%)
Query: 49 KRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKR 108
K + E LRR+ LE+++R+ E K+++ + K+ ++ + +EE+ ++
Sbjct: 362 KERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRR---------RLEEQQRRE 412
Query: 109 QATESHTSQGTDREYEMEEENEFLEYNHAESEQEY-----EEEQEPPKVESKPKVPLKSA 163
+ + R YE + E E AE EQEY EEEQ ++ + + ++
Sbjct: 413 KELRKQQEREQRRHYEEQMRRE-EERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQA- 470
Query: 164 PPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFL-ERKHRRKKLETDGK 222
LL ++KQ E ++ + + + +ER++L +H+R++ K
Sbjct: 471 --------LLLEYKRKQLE-------EQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK 515
Query: 223 LPPTVSKK--APSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSS 280
P K+ +PS+K + ++ + S SS MP A + S P++ + S S
Sbjct: 516 KPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE-SFSIS 574
Query: 281 KSMPGER--------------IKAGSGNSSQPSLREGHDKPVFNGAGKPHS---STSSPS 323
P + S + + + H++P +G + ++
Sbjct: 575 GVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVE 634
Query: 324 VPKTSASRTQK-----SAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSA 378
+P+ ++ T + + +E + S P P V + SP + + S + +
Sbjct: 635 MPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIP-PKVPQRTTSISPALARKNSPGNGS 693
Query: 379 PGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQP 438
P G ++P +S P RR S +R+ SGS ++ S PS QP
Sbjct: 694 ALGPRLG-SQPIRASNPDLRRTEPILESPLQRTSSGSS--SSSSTPS----------SQP 740
Query: 439 ASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSIS 497
+S G +GS R +S+ G PV PHE P R ++ P R S
Sbjct: 741 SSQGGSQPGSQAGSSERTRVRANSKSEGSPV-LPHE---PAKVKPEESRDITRPSRPAS 795
Score = 35.4 bits (80), Expect = 0.18
Identities = 111/558 (19%), Positives = 207/558 (37%), Gaps = 90/558 (16%)
Query: 120 DREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLR--LAE 177
DR + E + EY ++ SE+E EEE + + S +P +S D LR LA
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEE-EEENDSGEPSSILNLPGESTLR----RDFLRLQLAN 361
Query: 178 KKQFEPVEIKVVKKSE------ERPMTAEELREREFLERKHRRKKLETDGKLPPTVSK-- 229
K++ E + + +++ + +R + AE R++ E+K +R++LE + + K
Sbjct: 362 KERSEALRRQQLEQQQRENEEHKRQLLAE--RQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
Query: 230 -------------------KAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEK---KSRP 267
+A ++E + +L + R L H + + +
Sbjct: 420 EREQRRHYEEQMRREEERRRAEHEQEYIRRQLEE--EQRQLEILQQQLLHEQALLLEYKR 477
Query: 268 SMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVF------NGAGKPH----- 316
E+ A + + ER S + R KP++ + + KP
Sbjct: 478 KQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEV 537
Query: 317 ------SSTSSPSVPKTSASRTQKSAVEHKAKK-SLSHPSHSRPGPMVTPHN-------- 361
+ SSP++P A+R + +++ S+S +R PM+ P +
Sbjct: 538 EERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVA 597
Query: 362 -KAKSPGVRQPGSSSSSAPGQPSTGVA------RPTVSSGPVPRRQNGSSSSGPERSISG 414
K++ P + ++S S QP+ G++ T +PR+ + +S P
Sbjct: 598 VKSQGPAL----TASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRI 653
Query: 415 SK-------KPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGR 467
K + D P + + P +S G G + + S +P+ +S R
Sbjct: 654 EKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGS-QPIRASNPDLR 712
Query: 468 PVSSPHE--LRRPVSGLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVS 525
E L+R SG + S S GS P + S+ +S G V
Sbjct: 713 RTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVL 772
Query: 526 SSGPT-IKPKCTVVSETISSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQ 584
P +KP+ + S ++ + + + L R + + + T Y
Sbjct: 773 PHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSS 832
Query: 585 REYEEEDDDDDEYDSEME 602
E E E +++E D E E
Sbjct: 833 SE-ESESSEEEEEDGESE 849
Score = 30.8 bits (68), Expect = 4.3
Identities = 25/106 (23%), Positives = 54/106 (50%), Gaps = 5/106 (4%)
Query: 582 KRQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIF--GYDRKKYKDESDYALR 639
+RQ+ EE+ + + + E + + E +H E +R++ + E +Y R
Sbjct: 390 ERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRR 449
Query: 640 YMESSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR 685
+E +++Q E + L Q L E +R++ E ++R+A++L+R+
Sbjct: 450 QLEE--EQRQLEILQQQLLHEQALLLEYKRKQLE-EQRQAERLQRQ 492
>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
Length = 717
Score = 62.4 bits (150), Expect = 1e-09
Identities = 95/425 (22%), Positives = 164/425 (38%), Gaps = 44/425 (10%)
Query: 48 LKRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKR---TKDNFHGYNGIPIEEK 104
+ + E RR++++E KE V + E K +++ +A+R ++ + +N + IEE
Sbjct: 278 INKMEARPRRQSMKE---KEHQVVRNEEQKAEQEEGKVAQREEELEETGNQHNDVEIEEA 334
Query: 105 SKKRQATESHTSQGTDREYEMEEENEFLEYNHAES----EQEYEEEQEPPKV----ESKP 156
++ + + ++E E EE+ + +E E E E +++ +P +V E
Sbjct: 335 GEEEEKEIAIVHSDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQDSQPEEVMDVLEMVE 394
Query: 157 KVPLKSAPPPMNFTDLLRLAE------KKQFEP---VEIKVVKKSEERPMTAEELREREF 207
V A + T+ + E K+ EP EI+ K+ + E + +
Sbjct: 395 NVKHVIADQEVMETNRVESVEPSENEASKELEPEMEFEIEPDKECKSLSPGKENVSALDM 454
Query: 208 LERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRP 267
+ +++ E++ + P + SQ + S+ P S+ L A + P
Sbjct: 455 EKESEEKEEKESEPQPEPVAQPQPQSQPQLQLQSQSQPVLQSQPPSQPEDLSLAVLQPTP 514
Query: 268 SMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKT 327
+ E+ L K P E +K + +P L P K S + + KT
Sbjct: 515 QVTQEQGHLLPERKDFPVESVKL-TEVPVEPVLTV---HPESKSKTKTRSRSRGRARNKT 570
Query: 328 SASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVA 387
S SR++ S+ + S S S S + + S R SSSSS G S +
Sbjct: 571 SKSRSRSSSSSSSSSSSTSSSSGS--------SSSSGSSSSRSSSSSSSSTSGSSSRDSS 622
Query: 388 RPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGR 447
T SS R G R + +K + RR SG SS GG R
Sbjct: 623 SSTSSSSESRSRSRG-------RGHNRDRKHRRSVDRKRRDTSGL--ERSHKSSKGGSSR 673
Query: 448 PISGS 452
GS
Sbjct: 674 DTKGS 678
Score = 53.1 bits (126), Expect = 8e-07
Identities = 113/474 (23%), Positives = 181/474 (38%), Gaps = 79/474 (16%)
Query: 57 RKALEEKRRKEELV--KKRIELKHD-KKARAMAKRTKDNFHGYNGIPIEEK--------- 104
+K +EE +RK + +RIE K A +R + + EE+
Sbjct: 253 QKLIEESQRKMNALFEGRRIEFAEQINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKV 312
Query: 105 SKKRQATESHTSQGTDREYEM--EEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKS 162
+++ + E +Q D E E EEE + + H+++E+E EEE++ ++E K
Sbjct: 313 AQREEELEETGNQHNDVEIEEAGEEEEKEIAIVHSDAEKEQEEEEQKQEMEVK------- 365
Query: 163 APPPMNFTDLLRLAEKKQ-FEPVEIKVVKKSEERP---MTAEELREREFLERKHRRKKLE 218
M +R +EK+Q +P E+ V + E + +E+ E +E + E
Sbjct: 366 ----MEEETEVRESEKQQDSQPEEVMDVLEMVENVKHVIADQEVMETNRVESVEPSEN-E 420
Query: 219 TDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALS 278
+L P + + KE S G + S+ M EK+ + S + +A
Sbjct: 421 ASKELEPEMEFEIEPDKECK----SLSPGKENVSALDMEKESEEKEEKESEPQPEPVAQP 476
Query: 279 SSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVE 338
+S P ++++ S +PV S +V + + TQ+
Sbjct: 477 QPQSQPQLQLQSQS-------------QPVLQSQPPSQPEDLSLAVLQPTPQVTQEQG-- 521
Query: 339 HKAKKSLSHPSHSRP------GPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVS 392
H + P S P++T H P S S + S G AR S
Sbjct: 522 HLLPERKDFPVESVKLTEVPVEPVLTVH----------PESKSKTKTRSRSRGRARNKTS 571
Query: 393 SGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGS 452
+ SSSS S SGS ++ S+ SR + S + +S+SG R S S
Sbjct: 572 KSRSRSSSSSSSSSSSTSSSSGSSS-SSGSSSSRSSSSSS------SSTSGSSSRDSSSS 624
Query: 453 VSSARPLGS-SRGPGRPVSSPH-----ELRRPVSGLGPPGR-SVSGPGRSISGS 499
SS+ S SRG G H RR SGL + S G R GS
Sbjct: 625 TSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGS 678
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 62.0 bits (149), Expect = 2e-09
Identities = 95/389 (24%), Positives = 158/389 (40%), Gaps = 83/389 (21%)
Query: 48 LKRKEEE---LRRKALEEKRRKEELVKKRIELKHDK-KARAMAKRT-----------KDN 92
LK+ ++E L++ L+ K R++E KK IE + +K K + AK K+N
Sbjct: 617 LKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKEN 676
Query: 93 FHG------------YNGIPIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHA--- 137
F + + +E+KSK + + S +E + +E F E
Sbjct: 677 FFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKST---KEKHVSKERNFKEERDKIKK 733
Query: 138 ESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDL----------LRLAEKKQFEPVEIK 187
ESE+ + EE+ E + +P FT L L L EK+ + K
Sbjct: 734 ESEKSFREEKIKDLKEERENIPTDK---DSEFTSLGMSAIEESIGLHLVEKEIDIEKQEK 790
Query: 188 VVKKSEERPMTAEELRER--EFLERK--HRRKKLETDGK-------LPPTVSKKAPSQK- 235
+K+S+E+P +++E+ E +ERK + KK++ + K L V K K
Sbjct: 791 HIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKL 850
Query: 236 -------------ESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKS 282
+S T K + DR S + M H ++K E+HLA S K
Sbjct: 851 YSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPE----KERHLAESKEKH 906
Query: 283 MPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQ---KSAV-- 337
+ ++ K S NS +G +K K S S+ T++ Q KS++
Sbjct: 907 LMEKKNKQ-SDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVD 965
Query: 338 --EHKAKKSLSHPSHSRPGPMVTPHNKAK 364
+ + +K LS ++ P+ TP K K
Sbjct: 966 GNKAQHEKPLSLKEKTKDEPLKTPDGKEK 994
Score = 47.8 bits (112), Expect = 3e-05
Identities = 72/369 (19%), Positives = 144/369 (39%), Gaps = 53/369 (14%)
Query: 37 KGVQSAAVQAFLKRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGY 96
+G +S A K + E R+ ++ K KE+ K+R L K+ M K+ K
Sbjct: 861 EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKER-HLAESKEKHLMEKKNK------ 913
Query: 97 NGIPIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKP 156
+ + + +E ++ DRE + +E++ E + + + +EE++ V+
Sbjct: 914 -----QSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNK 968
Query: 157 KVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFLERKHRRK- 215
K L L EK + EP++ K+ +++ + +ER+ KH+ K
Sbjct: 969 AQHEKP----------LSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERD----KHKDKI 1014
Query: 216 ------KLETDGKLPPTVSKKA-----PSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKK 264
KL+++ P S A P +K V L + S +R S K + + KK
Sbjct: 1015 QINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKK 1074
Query: 265 SRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSV 324
+ + ++ L + + +K ++ + E +K + + +
Sbjct: 1075 HKEKIKQKEKERLRNRNCL---ELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEK 1131
Query: 325 PKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPST 384
A + +V+ K +L S V+ ++ +SP S + PG S
Sbjct: 1132 QPKDAVSNRSQSVDTKNVMTLGKSS------FVSDNSLNRSP------RSENEKPGLSSR 1179
Query: 385 GVARPTVSS 393
V+ +V+S
Sbjct: 1180 SVSMISVAS 1188
Score = 34.7 bits (78), Expect = 0.30
Identities = 30/111 (27%), Positives = 50/111 (45%), Gaps = 4/111 (3%)
Query: 146 EQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKV--VKKSEERPMTAEELR 203
E + P++ K + P P+ + L A++K + + V +K E +P ++E R
Sbjct: 1752 EDDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSE--R 1809
Query: 204 EREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSK 254
+ E H RKK+E KL +V +AP + T D +P SK
Sbjct: 1810 ANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSK 1860
Score = 30.4 bits (67), Expect = 5.7
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 10/94 (10%)
Query: 572 PQRLPFPTGYKRQREYEEEDDDDDEYDSEMED------FIEDEGEPQ-EEISKHIREIFG 624
P + P P+ EYE +DDDD+E + ++D E EP+ E+ ++
Sbjct: 326 PSKTPLPSALD---EYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKA 382
Query: 625 YDRKKYKDESDYALRYMESSWKEQQKEEAKSLRL 658
+ K +K + R + SS + +E ++ ++
Sbjct: 383 FYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKI 416
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 62.0 bits (149), Expect = 2e-09
Identities = 95/389 (24%), Positives = 158/389 (40%), Gaps = 83/389 (21%)
Query: 48 LKRKEEE---LRRKALEEKRRKEELVKKRIELKHDK-KARAMAKRT-----------KDN 92
LK+ ++E L++ L+ K R++E KK IE + +K K + AK K+N
Sbjct: 640 LKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKEN 699
Query: 93 FHG------------YNGIPIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHA--- 137
F + + +E+KSK + + S +E + +E F E
Sbjct: 700 FFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKST---KEKHVSKERNFKEERDKIKK 756
Query: 138 ESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDL----------LRLAEKKQFEPVEIK 187
ESE+ + EE+ E + +P FT L L L EK+ + K
Sbjct: 757 ESEKSFREEKIKDLKEERENIPTDK---DSEFTSLGMSAIEESIGLHLVEKEIDIEKQEK 813
Query: 188 VVKKSEERPMTAEELRER--EFLERK--HRRKKLETDGK-------LPPTVSKKAPSQK- 235
+K+S+E+P +++E+ E +ERK + KK++ + K L V K K
Sbjct: 814 HIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKL 873
Query: 236 -------------ESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKS 282
+S T K + DR S + M H ++K E+HLA S K
Sbjct: 874 YSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPE----KERHLAESKEKH 929
Query: 283 MPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQ---KSAV-- 337
+ ++ K S NS +G +K K S S+ T++ Q KS++
Sbjct: 930 LMEKKNKQ-SDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVD 988
Query: 338 --EHKAKKSLSHPSHSRPGPMVTPHNKAK 364
+ + +K LS ++ P+ TP K K
Sbjct: 989 GNKAQHEKPLSLKEKTKDEPLKTPDGKEK 1017
Score = 47.8 bits (112), Expect = 3e-05
Identities = 72/369 (19%), Positives = 144/369 (39%), Gaps = 53/369 (14%)
Query: 37 KGVQSAAVQAFLKRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGY 96
+G +S A K + E R+ ++ K KE+ K+R L K+ M K+ K
Sbjct: 884 EGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKER-HLAESKEKHLMEKKNK------ 936
Query: 97 NGIPIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKP 156
+ + + +E ++ DRE + +E++ E + + + +EE++ V+
Sbjct: 937 -----QSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNK 991
Query: 157 KVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFLERKHRRK- 215
K L L EK + EP++ K+ +++ + +ER+ KH+ K
Sbjct: 992 AQHEKP----------LSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERD----KHKDKI 1037
Query: 216 ------KLETDGKLPPTVSKKA-----PSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKK 264
KL+++ P S A P +K V L + S +R S K + + KK
Sbjct: 1038 QINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKK 1097
Query: 265 SRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSV 324
+ + ++ L + + +K ++ + E +K + + +
Sbjct: 1098 HKEKIKQKEKERLRNRNCL---ELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEK 1154
Query: 325 PKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPST 384
A + +V+ K +L S V+ ++ +SP S + PG S
Sbjct: 1155 QPKDAVSNRSQSVDTKNVMTLGKSS------FVSDNSLNRSP------RSENEKPGLSSR 1202
Query: 385 GVARPTVSS 393
V+ +V+S
Sbjct: 1203 SVSMISVAS 1211
Score = 34.7 bits (78), Expect = 0.30
Identities = 30/111 (27%), Positives = 50/111 (45%), Gaps = 4/111 (3%)
Query: 146 EQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKV--VKKSEERPMTAEELR 203
E + P++ K + P P+ + L A++K + + V +K E +P ++E R
Sbjct: 1775 EDDDPQIHHPRKRKVSRVPQPVQVSPSLLQAKEKTQQSLAAIVDSLKLDEIQPYSSE--R 1832
Query: 204 EREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSK 254
+ E H RKK+E KL +V +AP + T D +P SK
Sbjct: 1833 ANPYFEYLHIRKKIEEKRKLLCSVIPQAPQYYDEYVTFNGSYLLDGNPLSK 1883
Score = 30.4 bits (67), Expect = 5.7
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 10/94 (10%)
Query: 572 PQRLPFPTGYKRQREYEEEDDDDDEYDSEMED------FIEDEGEPQ-EEISKHIREIFG 624
P + P P+ EYE +DDDD+E + ++D E EP+ E+ ++
Sbjct: 349 PSKTPLPSALD---EYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKA 405
Query: 625 YDRKKYKDESDYALRYMESSWKEQQKEEAKSLRL 658
+ K +K + R + SS + +E ++ ++
Sbjct: 406 FYPKSFKSKKQKPSRVLYSSTESSDEEALQNKKI 439
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 61.6 bits (148), Expect = 2e-09
Identities = 102/476 (21%), Positives = 190/476 (39%), Gaps = 75/476 (15%)
Query: 49 KRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKR 108
K + E LRR+ LE+++R+ E K+++ + K+ ++ + +EE+ ++
Sbjct: 362 KERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRR---------RLEEQQRRE 412
Query: 109 QATESHTSQGTDREYEMEEENEFLEYNHAESEQEY-----EEEQEPPKVESKPKVPLKSA 163
+ + R YE + E E AE EQEY EEEQ ++ + + ++
Sbjct: 413 KELRKQQEREQRRHYEEQMRRE-EERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQA- 470
Query: 164 PPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFL-ERKHRRKKLETDGK 222
LL ++KQ E ++ + + + +ER++L +H+R++ K
Sbjct: 471 --------LLLEYKRKQLE-------EQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK 515
Query: 223 LPPTVSKK--APSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSS 280
P K+ +PS+K + ++ + S SS MP A + S P++ + S S
Sbjct: 516 KPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE-SFSIS 574
Query: 281 KSMPGER--------------IKAGSGNSSQPSLREGHDKPVFNGAGKPHS---STSSPS 323
P + S + + + H++P +G + ++
Sbjct: 575 GVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVE 634
Query: 324 VPKTSASRTQK-----SAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSA 378
+P+ ++ T + + +E + S P P V + SP + + S + +
Sbjct: 635 MPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIP-PKVPQRTTSISPALARKNSPGNGS 693
Query: 379 PGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQP 438
P G ++P +S P RR S +R+ SGS ++ S PS QP
Sbjct: 694 ALGPRLG-SQPIRASNPDLRRTEPILESPLQRTSSGSS--SSSSTPS----------SQP 740
Query: 439 ASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGR 494
+S G +GS R +S+ G PV PHE P R ++ P R
Sbjct: 741 SSQGGSQPGSQAGSSERTRVRANSKSEGSPV-LPHE---PAKVKPEESRDITRPSR 792
Score = 38.5 bits (88), Expect = 0.021
Identities = 113/558 (20%), Positives = 207/558 (37%), Gaps = 98/558 (17%)
Query: 120 DREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLR--LAE 177
DR + E + EY ++ SE+E EEE + + S +P +S D LR LA
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEE-EEENDSGEPSSILNLPGESTLR----RDFLRLQLAN 361
Query: 178 KKQFEPVEIKVVKKSE------ERPMTAEELREREFLERKHRRKKLETDGKLPPTVSK-- 229
K++ E + + +++ + +R + AE R++ E+K +R++LE + + K
Sbjct: 362 KERSEALRRQQLEQQQRENEEHKRQLLAE--RQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
Query: 230 -------------------KAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEK---KSRP 267
+A ++E + +L + R L H + + +
Sbjct: 420 EREQRRHYEEQMRREEERRRAEHEQEYIRRQLEE--EQRQLEILQQQLLHEQALLLEYKR 477
Query: 268 SMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVF------NGAGKPH----- 316
E+ A + + ER S + R KP++ + + KP
Sbjct: 478 KQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEV 537
Query: 317 ------SSTSSPSVPKTSASRTQKSAVEHKAKK-SLSHPSHSRPGPMVTPHN-------- 361
+ SSP++P A+R + +++ S+S +R PM+ P +
Sbjct: 538 EERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVA 597
Query: 362 -KAKSPGVRQPGSSSSSAPGQPSTGVA------RPTVSSGPVPRRQNGSSSSGPERSISG 414
K++ P + ++S S QP+ G++ T +PR+ + +S P
Sbjct: 598 VKSQGPAL----TASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRI 653
Query: 415 SK-------KPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGR 467
K + D P + + P +S G G + + S +P+ +S R
Sbjct: 654 EKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGS-QPIRASNPDLR 712
Query: 468 PVSSPHE--LRRPVSGLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVS 525
E L+R SG + S S GS P + S+ +S G V
Sbjct: 713 RTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVL 772
Query: 526 SSGPT-IKPKCTVVSETISSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQ 584
P +KP+ S++I S + + L R + + + T Y
Sbjct: 773 PHEPAKVKPE--------ESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSS 824
Query: 585 REYEEEDDDDDEYDSEME 602
E E E +++E D E E
Sbjct: 825 SE-ESESSEEEEEDGESE 841
Score = 30.8 bits (68), Expect = 4.3
Identities = 25/106 (23%), Positives = 54/106 (50%), Gaps = 5/106 (4%)
Query: 582 KRQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIF--GYDRKKYKDESDYALR 639
+RQ+ EE+ + + + E + + E +H E +R++ + E +Y R
Sbjct: 390 ERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRR 449
Query: 640 YMESSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR 685
+E +++Q E + L Q L E +R++ E ++R+A++L+R+
Sbjct: 450 QLEE--EQRQLEILQQQLLHEQALLLEYKRKQLE-EQRQAERLQRQ 492
>gi|32698936 B-cell CLL/lymphoma 9-like [Homo sapiens]
Length = 1499
Score = 60.5 bits (145), Expect = 5e-09
Identities = 83/323 (25%), Positives = 114/323 (35%), Gaps = 66/323 (20%)
Query: 291 GSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSH 350
G G+ P+L + H V + P ++ SP P + + PS
Sbjct: 928 GMGHLKSPTLSQVHSPLVTS----PSANLKSPQTPS----------------QMVPLPSA 967
Query: 351 SRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPER 410
+ PGP+ +P S VR P S S PS V P + P ++ P
Sbjct: 968 NPPGPLKSPQVLGSSLSVRSPTGSPSRLKS-PSMAVPSPGWVASP--------KTAMPSP 1018
Query: 411 SISGSKKPT---NDSNPSRRTVSGTCGPGQPASSSGGP-GRPISGSVSSARPLGSSRGP- 465
+S +K+P N S GT P P SSS P P SG ++ + P SS P
Sbjct: 1019 GVSQNKQPPLNMNSSTTLSNMEQGTLPPSGPRSSSSAPPANPPSGLMNPSLPFTSSPDPT 1078
Query: 466 ----------------GRPVSSP--HELRRPVSG----------LGPPGRSVSGPGRSIS 497
P S+P H + ++ L PP G G IS
Sbjct: 1079 PSQNPLSLMMTQMSKYAMPSSTPLYHNAIKTIATSDDELLPDRPLLPPPPPPQGSGPGIS 1138
Query: 498 GSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSETISSKNIISRSSNGQMN 557
S P+ ++++ P+ PGQ S P P + S T N I N Q
Sbjct: 1139 NSQPSQMHLNSAAAQSPMGMNLPGQQPLSHEP---PPAMLPSPTPLGSN-IPLHPNAQGT 1194
Query: 558 GMKPPLSGYRAAQGPQRLPFPTG 580
G P S A GP L P G
Sbjct: 1195 GGPPQNSMMMAPGGPDSLNAPCG 1217
Score = 46.2 bits (108), Expect = 1e-04
Identities = 81/341 (23%), Positives = 125/341 (36%), Gaps = 48/341 (14%)
Query: 215 KKLETDGKLPPTVSKKAPSQKES---VGTKLSKGSGDRHPS-----SKGMPLPH---AEK 263
K +T ++ P S P +S +G+ LS S PS S +P P + K
Sbjct: 953 KSPQTPSQMVPLPSANPPGPLKSPQVLGSSLSVRSPTGSPSRLKSPSMAVPSPGWVASPK 1012
Query: 264 KSRPS--MANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSS 321
+ PS ++ K L+ + S ++ G+ S P R P N P S +
Sbjct: 1013 TAMPSPGVSQNKQPPLNMNSSTTLSNMEQGTLPPSGP--RSSSSAPPAN----PPSGLMN 1066
Query: 322 PSVPKTSASRTQKSAVEHKAKKSLSHPS-HSRPGPMVTPHNKAKS------------PGV 368
PS+P TS+ S ++ ++ S ++ P HN K+ P +
Sbjct: 1067 PSLPFTSSPDPTPS--QNPLSLMMTQMSKYAMPSSTPLYHNAIKTIATSDDELLPDRPLL 1124
Query: 369 RQPGSSSSSAPG----QPSTGVARPTVSSGPVPRRQNGSS--SSGPERSISGSKKPTNDS 422
P S PG QPS + P+ G S P ++ S P +
Sbjct: 1125 PPPPPPQGSGPGISNSQPSQMHLNSAAAQSPMGMNLPGQQPLSHEPPPAMLPSPTPLGSN 1184
Query: 423 NPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGL 482
P GT GP Q S PG P S + P G + + P L++P +
Sbjct: 1185 IPLHPNAQGTGGPPQN-SMMMAPGGPDSLNA----PCGPVPSSSQMMPFPPRLQQPHGAM 1239
Query: 483 GPPGRSVSGPGRSISGSIPAGRTV-SNSVPGRPVSSLGPGQ 522
P G GPG + P+G + +P +P + P Q
Sbjct: 1240 APTGGGGGGPG--LQQHYPSGMALPPEDLPNQPPGPMPPQQ 1278
Score = 37.7 bits (86), Expect = 0.036
Identities = 61/264 (23%), Positives = 94/264 (35%), Gaps = 31/264 (11%)
Query: 288 IKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSH 347
+ G PS + F+G P+ + S TQ ++ +S+
Sbjct: 828 VMGGPQKMLMPSQFPNQGQQGFSGGQGPYQAMSQ------DMGNTQDMFSPDQSSMPMSN 881
Query: 348 PSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSG 407
+R M P P PG+ S+ P+ G+ R S + Q GS G
Sbjct: 882 VGTTRLSHMPLP------PASNPPGTVHSA----PNRGLGRRP-SDLTISINQMGSPGMG 930
Query: 408 PERS--ISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGP 465
+S +S P S PS S P P+ P G + S + LGSS
Sbjct: 931 HLKSPTLSQVHSPLVTS-PSANLKS----PQTPSQMVPLPSANPPGPLKSPQVLGSSLSV 985
Query: 466 GRPVSSPHELRRPVSGLGPPG------RSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLG 519
P SP L+ P + PG ++ PG S + P S ++ +L
Sbjct: 986 RSPTGSPSRLKSPSMAVPSPGWVASPKTAMPSPGVSQNKQPPLNMNSSTTLSNMEQGTLP 1045
Query: 520 P-GQTVSSSGPTIKPKCTVVSETI 542
P G SSS P P +++ ++
Sbjct: 1046 PSGPRSSSSAPPANPPSGLMNPSL 1069
Score = 33.1 bits (74), Expect = 0.88
Identities = 48/197 (24%), Positives = 66/197 (33%), Gaps = 19/197 (9%)
Query: 304 HDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHS---RPGPMVTPH 360
H K GA H + + P + A H AK + PS+S P V P
Sbjct: 47 HGKTGNGGAQSQHQNVNQG--PTCNVGSKGVGAGNHGAKANQISPSNSSLKNPQAGVPPF 104
Query: 361 NKAKSPGVRQPGSSSSSAP----GQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSK 416
+ K R S S G PS V+ P +R+ P
Sbjct: 105 SSLKGKVKRDRSVSVDSGEQREAGTPSLDSEAKEVA--PRSKRRCVLERKQPYSGDEWCS 162
Query: 417 KPTNDSNPSRRTVSGTCGPGQPASSSG--GPGRPISGSVSSARPLGSSRGPGRPVSSPHE 474
P ++ + + C PA ++ GPG+ ++ PL S PG P P
Sbjct: 163 GPDSEEDDKPIGATHNCNVADPAMAAPQLGPGQ------TTQLPLSESSVPGAPHGPPPG 216
Query: 475 LRRPVSGLGPPGRSVSG 491
LR G G G V G
Sbjct: 217 LRPDAPGGGGGGGGVPG 233
Score = 32.7 bits (73), Expect = 1.1
Identities = 51/219 (23%), Positives = 80/219 (36%), Gaps = 37/219 (16%)
Query: 259 PHAEKKSRPSMA----NEKHLALSSSKSMPGERIKAGSGNSSQPSLREGH------DKPV 308
P +E+ +P A N A+++ + PG+ + SS P G D P
Sbjct: 164 PDSEEDDKPIGATHNCNVADPAMAAPQLGPGQTTQLPLSESSVPGAPHGPPPGLRPDAPG 223
Query: 309 FNGAG-----KPHS-----------STSSPSVPKTSASRT----QKSAVEHKAKKSLSHP 348
G G KP S +T++ +V + A Q++ K ++ P
Sbjct: 224 GGGGGGGVPGKPPSQFVYVFTTHLANTAAEAVLQGRADSILAYHQQNVPRAKLDQAPKVP 283
Query: 349 SHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTV--SSGPVPRRQNGSSSS 406
P P+ TP S G Q P P+ G A P + P Q+ + +S
Sbjct: 284 PTPEPLPLSTP-----SAGTPQSQPPPLPPPPPPAPGSAPPALPPEGPPEDSSQDLAPNS 338
Query: 407 GPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGP 445
S G T+ + P+ T + PG SS+ GP
Sbjct: 339 VGAASTGGGTGGTHPNTPTATTANNPLPPGGDPSSAPGP 377
>gi|55750053 atrophin-1 [Homo sapiens]
Length = 1190
Score = 59.3 bits (142), Expect = 1e-08
Identities = 92/421 (21%), Positives = 148/421 (35%), Gaps = 64/421 (15%)
Query: 100 PIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHA-ESEQEYEEEQEPPKVESKPKV 158
P S A S +S + Y H+ +PPK ++P +
Sbjct: 374 PYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKY-TQPSL 432
Query: 159 PLKSA-----PPPMNFTDLLRL-------------AEKKQFEPVEIKVVKKSEERPMTAE 200
P ++ PPP + LL A+ PV +++ +
Sbjct: 433 PSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQ 492
Query: 201 ELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKG-MPLP 259
+ ++++ ++ H G P + + S GS +P +P P
Sbjct: 493 QQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPP 552
Query: 260 HAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSST 319
H++ + N ++ SS+ S ++SQ S H P G P+
Sbjct: 553 HSQVSYSQAGPNGPPVSSSSNSS----------SSTSQGSYPCSHPSPSQGPQGAPYPFP 602
Query: 320 SSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNK-AKSPGVRQPGSSSSSA 378
P+V +SA T + + A + + S PGP P+ K A SPG + +
Sbjct: 603 PVPTVTTSSA--TLSTVIATVASSPAGYKTASPPGP--PPYGKRAPSPGAYKTATPPGYK 658
Query: 379 PGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPG-- 436
PG P P+ +G P + S +GP G+ KP S T GPG
Sbjct: 659 PGSP------PSFRTGTPPGYRGTSPPAGP-----GTFKPG----------SPTVGPGPL 697
Query: 437 QPASSSGGPG-RPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRS 495
PA SG P P + +S PL +++ P PV PP RS S P +
Sbjct: 698 PPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPV----PPARSPSPPPKV 753
Query: 496 I 496
+
Sbjct: 754 V 754
Score = 47.4 bits (111), Expect = 4e-05
Identities = 110/489 (22%), Positives = 165/489 (33%), Gaps = 71/489 (14%)
Query: 139 SEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMT 198
SE E EE P K +++ ++P +P ++ D L + +P +I ++ T
Sbjct: 77 SESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDI-----DQDNRST 131
Query: 199 AEELREREFLERKHRRKKLETDGKL----PPTVSKKAPSQKESVGTKLSKGSGDRHPS-- 252
+ + +E + G PP + +P +S + + S + HPS
Sbjct: 132 SPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDST-PRQPEASFEPHPSVT 190
Query: 253 SKGMPLPHAEKKSR----PSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPV 308
G P SR P A H L PG SG P
Sbjct: 191 PTGYHAPMEPPTSRMFQAPPGAPPPHPQL-----YPGGTGGVLSGPPMGPKGGGAASSVG 245
Query: 309 FNGAGKPHSSTSSP-SVPKTSASRTQKSAVEHKAKKSLSHPSHSRPG--PMVTPHNKAKS 365
GK H ++P SV + AS + + PS P P VTP N
Sbjct: 246 GPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTP-NLPPP 304
Query: 366 PGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQN---GSSSSGPERSISGSKKPTNDS 422
P +R ++S+S PG A+P P P G GPE K PT
Sbjct: 305 PALRPLNNASASPPGLG----AQPLPGHLPSPHAMGQGMGGLPPGPE------KGPTLAP 354
Query: 423 NPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGL 482
+P P +SS P P+ SS+ ++ SS S
Sbjct: 355 SPH----------SLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSS--------SSA 396
Query: 483 GPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSETI 542
P S + P S P +VSN P SL P Q V S GP P +
Sbjct: 397 SPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSL-PSQAVWSQGPPPPPP---YGRLL 452
Query: 543 SSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEME 602
++ N G PP +G AQ P T + ++ +++ + + +
Sbjct: 453 ANSN--------AHPGPFPPSTG---AQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQ 501
Query: 603 DFIEDEGEP 611
+ G P
Sbjct: 502 QHHGNSGPP 510
Score = 33.5 bits (75), Expect = 0.67
Identities = 73/309 (23%), Positives = 112/309 (36%), Gaps = 56/309 (18%)
Query: 346 SHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSS 405
S S+S+ GP P + + S+SSS+ Q S + P+ S GP Q
Sbjct: 554 SQVSYSQAGPNGPPVSSS---------SNSSSSTSQGSYPCSHPSPSQGP----QGAPYP 600
Query: 406 SGPERSISGSKK------PTNDSNPSRRTVSGTCGP---GQPASSSGG----------PG 446
P +++ S T S+P+ + GP G+ A S G PG
Sbjct: 601 FPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPG 660
Query: 447 RPIS---GSVSSARPLGSSRGPGR-PVSSPHELRRPVSGLGPPG-RSVSGPGRSISGSIP 501
P S G+ R GPG SP P+ GP G S+ P + + P
Sbjct: 661 SPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPP 720
Query: 502 AGRTVSNSVPGR----PVSSLGPGQTVSSSGPTIKPKCTVVSETISSKNIISRSSNGQMN 557
T P P S + P ++ P+ PK V S ++ + N
Sbjct: 721 LSATQIKQEPAEEYETPESPVPPARS-----PSPPPKVVDVPSHASQSARFNKHLDRGFN 775
Query: 558 GMK------PPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEMEDFIEDEGEP 611
PL G + A+ L K +RE E+ ++ E + E E E E E
Sbjct: 776 SCARSDLYFVPLEGSKLAKKRADLV----EKVRREAEQRAREEKEREREREREKEREREK 831
Query: 612 QEEISKHIR 620
+ E+ + ++
Sbjct: 832 ERELERSVK 840
Score = 30.4 bits (67), Expect = 5.7
Identities = 61/296 (20%), Positives = 102/296 (34%), Gaps = 47/296 (15%)
Query: 138 ESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAE-------------------- 177
E +EYE + P P P K P + + R +
Sbjct: 729 EPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLE 788
Query: 178 -----KKQFEPVEIKVVKKSEERPMTAEEL-REREFLERKHRRKKLETDGKLPPTVSKKA 231
KK+ + VE KV +++E+R +E RERE + + R K+ E + + +A
Sbjct: 789 GSKLAKKRADLVE-KVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRA 847
Query: 232 PSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAG 291
P + S+G + + P S +P P++ A S
Sbjct: 848 PVECPSLGPVPHRPPFE--PGSAVATVPPYLGPDTPALRTLSEYARPHVMS--------- 896
Query: 292 SGNSSQP-SLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEH-----KAKKSL 345
GN + P + G P G P +S P+ + ++ + + K S
Sbjct: 897 PGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSE 956
Query: 346 SHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGV---ARPTVSSGPVPR 398
P H PGP + P + ++ P PS G R +++GP R
Sbjct: 957 LEPLHGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALR 1012
>gi|55750041 atrophin-1 [Homo sapiens]
Length = 1190
Score = 59.3 bits (142), Expect = 1e-08
Identities = 92/421 (21%), Positives = 148/421 (35%), Gaps = 64/421 (15%)
Query: 100 PIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHA-ESEQEYEEEQEPPKVESKPKV 158
P S A S +S + Y H+ +PPK ++P +
Sbjct: 374 PYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKY-TQPSL 432
Query: 159 PLKSA-----PPPMNFTDLLRL-------------AEKKQFEPVEIKVVKKSEERPMTAE 200
P ++ PPP + LL A+ PV +++ +
Sbjct: 433 PSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQ 492
Query: 201 ELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKG-MPLP 259
+ ++++ ++ H G P + + S GS +P +P P
Sbjct: 493 QQQQQQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPP 552
Query: 260 HAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSST 319
H++ + N ++ SS+ S ++SQ S H P G P+
Sbjct: 553 HSQVSYSQAGPNGPPVSSSSNSS----------SSTSQGSYPCSHPSPSQGPQGAPYPFP 602
Query: 320 SSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNK-AKSPGVRQPGSSSSSA 378
P+V +SA T + + A + + S PGP P+ K A SPG + +
Sbjct: 603 PVPTVTTSSA--TLSTVIATVASSPAGYKTASPPGP--PPYGKRAPSPGAYKTATPPGYK 658
Query: 379 PGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPG-- 436
PG P P+ +G P + S +GP G+ KP S T GPG
Sbjct: 659 PGSP------PSFRTGTPPGYRGTSPPAGP-----GTFKPG----------SPTVGPGPL 697
Query: 437 QPASSSGGPG-RPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRS 495
PA SG P P + +S PL +++ P PV PP RS S P +
Sbjct: 698 PPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPV----PPARSPSPPPKV 753
Query: 496 I 496
+
Sbjct: 754 V 754
Score = 47.4 bits (111), Expect = 4e-05
Identities = 110/489 (22%), Positives = 165/489 (33%), Gaps = 71/489 (14%)
Query: 139 SEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMT 198
SE E EE P K +++ ++P +P ++ D L + +P +I ++ T
Sbjct: 77 SESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDI-----DQDNRST 131
Query: 199 AEELREREFLERKHRRKKLETDGKL----PPTVSKKAPSQKESVGTKLSKGSGDRHPS-- 252
+ + +E + G PP + +P +S + + S + HPS
Sbjct: 132 SPSIYSPGSVENDSDSSSGLSQGPARPYHPPPLFPPSPQPPDST-PRQPEASFEPHPSVT 190
Query: 253 SKGMPLPHAEKKSR----PSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPV 308
G P SR P A H L PG SG P
Sbjct: 191 PTGYHAPMEPPTSRMFQAPPGAPPPHPQL-----YPGGTGGVLSGPPMGPKGGGAASSVG 245
Query: 309 FNGAGKPHSSTSSP-SVPKTSASRTQKSAVEHKAKKSLSHPSHSRPG--PMVTPHNKAKS 365
GK H ++P SV + AS + + PS P P VTP N
Sbjct: 246 GPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTP-NLPPP 304
Query: 366 PGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQN---GSSSSGPERSISGSKKPTNDS 422
P +R ++S+S PG A+P P P G GPE K PT
Sbjct: 305 PALRPLNNASASPPGLG----AQPLPGHLPSPHAMGQGMGGLPPGPE------KGPTLAP 354
Query: 423 NPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGL 482
+P P +SS P P+ SS+ ++ SS S
Sbjct: 355 SPH----------SLPPASSSAPAPPMRFPYSSSSSSSAAASSSSSSSS--------SSA 396
Query: 483 GPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPKCTVVSETI 542
P S + P S P +VSN P SL P Q V S GP P +
Sbjct: 397 SPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSL-PSQAVWSQGPPPPPP---YGRLL 452
Query: 543 SSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEME 602
++ N G PP +G AQ P T + ++ +++ + + +
Sbjct: 453 ANSN--------AHPGPFPPSTG---AQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQ 501
Query: 603 DFIEDEGEP 611
+ G P
Sbjct: 502 QHHGNSGPP 510
Score = 33.5 bits (75), Expect = 0.67
Identities = 73/309 (23%), Positives = 112/309 (36%), Gaps = 56/309 (18%)
Query: 346 SHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSS 405
S S+S+ GP P + + S+SSS+ Q S + P+ S GP Q
Sbjct: 554 SQVSYSQAGPNGPPVSSS---------SNSSSSTSQGSYPCSHPSPSQGP----QGAPYP 600
Query: 406 SGPERSISGSKK------PTNDSNPSRRTVSGTCGP---GQPASSSGG----------PG 446
P +++ S T S+P+ + GP G+ A S G PG
Sbjct: 601 FPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKPG 660
Query: 447 RPIS---GSVSSARPLGSSRGPGR-PVSSPHELRRPVSGLGPPG-RSVSGPGRSISGSIP 501
P S G+ R GPG SP P+ GP G S+ P + + P
Sbjct: 661 SPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPP 720
Query: 502 AGRTVSNSVPGR----PVSSLGPGQTVSSSGPTIKPKCTVVSETISSKNIISRSSNGQMN 557
T P P S + P ++ P+ PK V S ++ + N
Sbjct: 721 LSATQIKQEPAEEYETPESPVPPARS-----PSPPPKVVDVPSHASQSARFNKHLDRGFN 775
Query: 558 GMK------PPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEMEDFIEDEGEP 611
PL G + A+ L K +RE E+ ++ E + E E E E E
Sbjct: 776 SCARSDLYFVPLEGSKLAKKRADLV----EKVRREAEQRAREEKEREREREREKEREREK 831
Query: 612 QEEISKHIR 620
+ E+ + ++
Sbjct: 832 ERELERSVK 840
Score = 30.4 bits (67), Expect = 5.7
Identities = 61/296 (20%), Positives = 102/296 (34%), Gaps = 47/296 (15%)
Query: 138 ESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAE-------------------- 177
E +EYE + P P P K P + + R +
Sbjct: 729 EPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLE 788
Query: 178 -----KKQFEPVEIKVVKKSEERPMTAEEL-REREFLERKHRRKKLETDGKLPPTVSKKA 231
KK+ + VE KV +++E+R +E RERE + + R K+ E + + +A
Sbjct: 789 GSKLAKKRADLVE-KVRREAEQRAREEKEREREREREKEREREKERELERSVKLAQEGRA 847
Query: 232 PSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERIKAG 291
P + S+G + + P S +P P++ A S
Sbjct: 848 PVECPSLGPVPHRPPFE--PGSAVATVPPYLGPDTPALRTLSEYARPHVMS--------- 896
Query: 292 SGNSSQP-SLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEH-----KAKKSL 345
GN + P + G P G P +S P+ + ++ + + K S
Sbjct: 897 PGNRNHPFYVPLGAVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKPGFEVKPSE 956
Query: 346 SHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGV---ARPTVSSGPVPR 398
P H PGP + P + ++ P PS G R +++GP R
Sbjct: 957 LEPLHGVPGPGLDPFPRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGPALR 1012
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 58.9 bits (141), Expect = 1e-08
Identities = 100/454 (22%), Positives = 172/454 (37%), Gaps = 80/454 (17%)
Query: 49 KRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKR 108
K + E LRR+ LE+++R+ E K+++ + K+ IEE+ ++R
Sbjct: 362 KERSEALRRQQLEQQQRENEEHKRQLLAERQKR-------------------IEEQKEQR 402
Query: 109 QATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMN 168
+ E RE E+ ++ E + H E + EEE+
Sbjct: 403 RRLEEQQR----REKELRKQQEREQRRHYEEQMRREEER--------------------- 437
Query: 169 FTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVS 228
R AE +Q E + ++ ++ + + ++L + L +++RK+LE +
Sbjct: 438 -----RRAEHEQ-EYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERL-- 489
Query: 229 KKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEK----KSRPSMANE-KHLALSSSKSM 283
++ Q+ L ++ P K PL H ++ +P+ A E HL S+
Sbjct: 490 QRQLKQERDYLVSLQHQRQEQRPVEK-KPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQ-- 546
Query: 284 PGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKK 343
G + A QP+ + N S P TS + + +E +
Sbjct: 547 -GPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDP-TSENPPLPTRIEKFDRS 604
Query: 344 SLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGS 403
S P P V + SP + + S + + P G ++P +S P RR
Sbjct: 605 SWLRQEEDIP-PKVPQRTTSISPALARKNSPGNGSALGPRLG-SQPIRASNPDLRRTEPI 662
Query: 404 SSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSR 463
S +R+ SGS ++ S PS QP+S G +GS R +S+
Sbjct: 663 LESPLQRTSSGSS--SSSSTPS----------SQPSSQGGSQPGSQAGSSERTRVRANSK 710
Query: 464 GPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSIS 497
G PV PHE P R ++ P R S
Sbjct: 711 SEGSPV-LPHE---PAKVKPEESRDITRPSRPAS 740
Score = 44.3 bits (103), Expect = 4e-04
Identities = 71/348 (20%), Positives = 139/348 (39%), Gaps = 33/348 (9%)
Query: 48 LKRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEE---- 103
L++++E +R+ EE+ R+EE ++R E + + R + + + + E+
Sbjct: 415 LRKQQEREQRRHYEEQMRREE-ERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLL 473
Query: 104 KSKKRQATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKP----KVP 159
+ K++Q E ++ R+ + E + + S Q +EQ P VE KP K
Sbjct: 474 EYKRKQLEEQRQAERLQRQLKQERD-------YLVSLQHQRQEQRP--VEKKPLYHYKEG 524
Query: 160 LKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFLERKHRRKKLET 219
+ + P ++ L K P + + E+P T +E L R ++
Sbjct: 525 MSPSEKPAWAKEIPHLVAVKSQGPA-LTASQSVHEQP-TKGLSGFQEALNVTSHRVEMPR 582
Query: 220 DGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSS 279
P + + P++ E K + S R +P P++A +
Sbjct: 583 QNSDPTSENPPLPTRIE----KFDRSSWLRQEEDIPPKVPQRTTSISPALARKNS---PG 635
Query: 280 SKSMPGERIKAGSGNSSQPSLREGH---DKPVFNGAGKPHSSTSSPSVPKTSASRTQKSA 336
+ S G R+ + +S P LR + P+ + SS+S+PS +S +Q +
Sbjct: 636 NGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGS 695
Query: 337 VEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPST 384
++++ + G V PH AK V+ S + P +P++
Sbjct: 696 QAGSSERTRVRANSKSEGSPVLPHEPAK---VKPEESRDITRPSRPAS 740
Score = 34.7 bits (78), Expect = 0.30
Identities = 109/525 (20%), Positives = 182/525 (34%), Gaps = 79/525 (15%)
Query: 120 DREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLR--LAE 177
DR + E + EY ++ SE+E EEE + + S +P +S D LR LA
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEE-EEENDSGEPSSILNLPGESTLR----RDFLRLQLAN 361
Query: 178 KKQFEPVEIKVVKKSE------ERPMTAEELREREFLERKHRRKKLETDGKLPPTVSK-- 229
K++ E + + +++ + +R + AE R++ E+K +R++LE + + K
Sbjct: 362 KERSEALRRQQLEQQQRENEEHKRQLLAE--RQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
Query: 230 -------------------KAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEK---KSRP 267
+A ++E + +L + R L H + + +
Sbjct: 420 EREQRRHYEEQMRREEERRRAEHEQEYIRRQLEE--EQRQLEILQQQLLHEQALLLEYKR 477
Query: 268 SMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFN---GAGKPHSSTSSPSV 324
E+ A + + ER S + R KP+++ G + +
Sbjct: 478 KQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEI 537
Query: 325 PKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKA---KSPGVRQPGSSSSSAPGQ 381
P A ++Q A+ + S H +P ++ +A S V P +S
Sbjct: 538 PHLVAVKSQGPAL------TASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSEN 591
Query: 382 PSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASS 441
P R++ P+R+ S S ++P + G QP +
Sbjct: 592 PPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRA 651
Query: 442 SGGPGR---PISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSISG 498
S R PI S GSS P S P G PG S +G
Sbjct: 652 SNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSS-----QGGSQPG--------SQAG 698
Query: 499 SIPAGRTVSNS-VPGRPVSSLGPGQTVSSSGPTIKPKCTVVSETISSKNIISRSSNGQMN 557
S R +NS G PV P + I T S S K I +
Sbjct: 699 SSERTRVRANSKSEGSPVLPHEPAKVKPEESRDI----TRPSRPASYKKAIDE----DLT 750
Query: 558 GMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEME 602
+ L R + + + T Y E E E +++E D E E
Sbjct: 751 ALAKELRELRIEETNRPMKKVTDYSSSSE-ESESSEEEEEDGESE 794
Score = 30.8 bits (68), Expect = 4.3
Identities = 25/106 (23%), Positives = 54/106 (50%), Gaps = 5/106 (4%)
Query: 582 KRQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIF--GYDRKKYKDESDYALR 639
+RQ+ EE+ + + + E + + E +H E +R++ + E +Y R
Sbjct: 390 ERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRR 449
Query: 640 YMESSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR 685
+E +++Q E + L Q L E +R++ E ++R+A++L+R+
Sbjct: 450 QLEE--EQRQLEILQQQLLHEQALLLEYKRKQLE-EQRQAERLQRQ 492
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 58.9 bits (141), Expect = 1e-08
Identities = 107/453 (23%), Positives = 167/453 (36%), Gaps = 78/453 (17%)
Query: 228 SKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGER 287
S+++ S++E G ++ G KG+ + A + S+ L +
Sbjct: 696 SEESDSEEEKTGLAVTVGQAKS--VGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQ 753
Query: 288 IKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSH 347
+KA S+ S E + + +SP+ KTS +TQ A A+ +
Sbjct: 754 VKAEKQEDSESSEEESDSE----------EAAASPAQVKTSVKKTQAKANPAAARAPSAK 803
Query: 348 PSHSRPGPMVTPHNKAK-------SPGVRQPGSSSSSAPGQ---PSTGVARPTVSSGPV- 396
+ S PG +VT +AK P VR P +S+ A G PS G A T +
Sbjct: 804 GTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTG 863
Query: 397 PRRQNGS----SSSGPERSISGSKKPTNDSNPSR----------RTVSGTCGPGQPASSS 442
P +GS S S E KP+ ++ R R + PG+ S+
Sbjct: 864 PEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSA 923
Query: 443 GGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGP---PGRSVSGPGRSISGS 499
G+ SS P V+S ++ P+ + P P + P ++ + S
Sbjct: 924 AQAGKQDDSGSSSEESDSDGEAPA-AVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAAS 982
Query: 500 IPAGRTVSNSVPGRPVSS-------------LGPG-----QTVSSSGPTIKPKCTVVSET 541
P S S R SS L PG T+ ++ P I PK ++ +
Sbjct: 983 TPRKARASEST-ARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGAS 1041
Query: 542 ISSKNIISRSSNGQMN-----------GMKP---PLSGYRAAQGPQRLPFP-TGYKRQRE 586
S ++ SR S+G+ G P P S A+G +L P +Q
Sbjct: 1042 SSKES--SRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQAT 1099
Query: 587 YEEEDDDDDEYDSEMEDFIEDEGE-PQEEISKH 618
E DD E S+ E++GE PQ S H
Sbjct: 1100 KAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAH 1132
Score = 31.2 bits (69), Expect = 3.3
Identities = 64/349 (18%), Positives = 109/349 (31%), Gaps = 62/349 (17%)
Query: 323 SVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQP 382
S ++S + A KA L+ + S G + K K+ + + ++ P
Sbjct: 83 STSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHP 142
Query: 383 STGVARPTVSSGPVPRR--------------------------------QNGSSSSGPER 410
+TG + SG PR+ G + S E
Sbjct: 143 ATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSED 202
Query: 411 SISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARP--LGSSRGPGRP 468
+ S S + + PS + S P G V P G + P +
Sbjct: 203 TSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKR 262
Query: 469 VSSP-HELRRPVSGLGPPGRSVSGPGRSISGS-----IPAGRTVSNSVPGRPVSSLGPGQ 522
P E G + +G + S + A + PG+ + PG+
Sbjct: 263 AKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGK 322
Query: 523 --TVSSSGPTIKPKCTVVS----------ETISSKNIISRSSNGQMN--------GMKPP 562
V+S KP+ S ET ++K ++ ++G+ + + P
Sbjct: 323 AGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESP 382
Query: 563 LSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEMEDFIEDEGEP 611
G AA P P K Q EED +S+ E+ + +P
Sbjct: 383 RKG--AAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKP 429
Score = 30.0 bits (66), Expect = 7.4
Identities = 25/92 (27%), Positives = 43/92 (46%), Gaps = 20/92 (21%)
Query: 37 KGVQSAAVQAFLKRKEEELRR-------------KALEEKRRKEELVKKRIELKHDKKAR 83
KG S Q EEEL++ K+ +EK++ ++ +K+ + K +KK +
Sbjct: 1366 KGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDK--RKKDKEKKEKKKK 1423
Query: 84 AMAKRTKDNFHGYNGIPIEEKSKKRQATESHT 115
A TKD+ P ++K KK++ T T
Sbjct: 1424 AKKASTKDSES-----PSQKKKKKKKKTAEQT 1450
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 58.9 bits (141), Expect = 1e-08
Identities = 107/453 (23%), Positives = 167/453 (36%), Gaps = 78/453 (17%)
Query: 228 SKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGER 287
S+++ S++E G ++ G KG+ + A + S+ L +
Sbjct: 696 SEESDSEEEKTGLAVTVGQAKS--VGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQ 753
Query: 288 IKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSH 347
+KA S+ S E + + +SP+ KTS +TQ A A+ +
Sbjct: 754 VKAEKQEDSESSEEESDSE----------EAAASPAQVKTSVKKTQAKANPAAARAPSAK 803
Query: 348 PSHSRPGPMVTPHNKAK-------SPGVRQPGSSSSSAPGQ---PSTGVARPTVSSGPV- 396
+ S PG +VT +AK P VR P +S+ A G PS G A T +
Sbjct: 804 GTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTG 863
Query: 397 PRRQNGS----SSSGPERSISGSKKPTNDSNPSR----------RTVSGTCGPGQPASSS 442
P +GS S S E KP+ ++ R R + PG+ S+
Sbjct: 864 PEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSA 923
Query: 443 GGPGRPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGP---PGRSVSGPGRSISGS 499
G+ SS P V+S ++ P+ + P P + P ++ + S
Sbjct: 924 AQAGKQDDSGSSSEESDSDGEAPA-AVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAAS 982
Query: 500 IPAGRTVSNSVPGRPVSS-------------LGPG-----QTVSSSGPTIKPKCTVVSET 541
P S S R SS L PG T+ ++ P I PK ++ +
Sbjct: 983 TPRKARASEST-ARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGAS 1041
Query: 542 ISSKNIISRSSNGQMN-----------GMKP---PLSGYRAAQGPQRLPFP-TGYKRQRE 586
S ++ SR S+G+ G P P S A+G +L P +Q
Sbjct: 1042 SSKES--SRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQAT 1099
Query: 587 YEEEDDDDDEYDSEMEDFIEDEGE-PQEEISKH 618
E DD E S+ E++GE PQ S H
Sbjct: 1100 KAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAH 1132
Score = 31.2 bits (69), Expect = 3.3
Identities = 64/349 (18%), Positives = 109/349 (31%), Gaps = 62/349 (17%)
Query: 323 SVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQP 382
S ++S + A KA L+ + S G + K K+ + + ++ P
Sbjct: 83 STSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHP 142
Query: 383 STGVARPTVSSGPVPRR--------------------------------QNGSSSSGPER 410
+TG + SG PR+ G + S E
Sbjct: 143 ATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSED 202
Query: 411 SISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARP--LGSSRGPGRP 468
+ S S + + PS + S P G V P G + P +
Sbjct: 203 TSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKR 262
Query: 469 VSSP-HELRRPVSGLGPPGRSVSGPGRSISGS-----IPAGRTVSNSVPGRPVSSLGPGQ 522
P E G + +G + S + A + PG+ + PG+
Sbjct: 263 AKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGK 322
Query: 523 --TVSSSGPTIKPKCTVVS----------ETISSKNIISRSSNGQMN--------GMKPP 562
V+S KP+ S ET ++K ++ ++G+ + + P
Sbjct: 323 AGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESP 382
Query: 563 LSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEMEDFIEDEGEP 611
G AA P P K Q EED +S+ E+ + +P
Sbjct: 383 RKG--AAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKP 429
Score = 30.0 bits (66), Expect = 7.4
Identities = 25/92 (27%), Positives = 43/92 (46%), Gaps = 20/92 (21%)
Query: 37 KGVQSAAVQAFLKRKEEELRR-------------KALEEKRRKEELVKKRIELKHDKKAR 83
KG S Q EEEL++ K+ +EK++ ++ +K+ + K +KK +
Sbjct: 1365 KGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDK--RKKDKEKKEKKKK 1422
Query: 84 AMAKRTKDNFHGYNGIPIEEKSKKRQATESHT 115
A TKD+ P ++K KK++ T T
Sbjct: 1423 AKKASTKDSES-----PSQKKKKKKKKTAEQT 1449
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 58.9 bits (141), Expect = 1e-08
Identities = 125/556 (22%), Positives = 195/556 (35%), Gaps = 108/556 (19%)
Query: 49 KRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKR 108
+++E E RR+ EEKRR EEL ++R E + ++A KR + Y +EE+ +
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEE-EKRRVEREQEYIRRQLEEEQRHL 479
Query: 109 QATESHTSQGTD-----REYEMEEENE--------------FLEYNHAESEQEYEEEQEP 149
+ + Q R EMEE + L H + Q+P
Sbjct: 480 EVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQP 539
Query: 150 PKVESKPKVPLKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFLE 209
P + + P AP P K +EP A+ RE E
Sbjct: 540 PPPQQERSKPSFHAPEP-----------KAHYEP---------------ADRAREVEDRF 573
Query: 210 RKHRRKKLETDGKLPPTV-SKKAPSQKESVGTKLSKGSGDR-HPSSKGMPLPHAEKKSRP 267
RK E K V PS+ ES S G+ + HP+ ++ + P
Sbjct: 574 RKTNHSSPEAQSKQTGRVLEPPVPSRSES----FSNGNSESVHPA--------LQRPAEP 621
Query: 268 SMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPK- 326
+ HLA + P R S + S PS + H H + P P
Sbjct: 622 QV-QWSHLASLKNNVSPVSR----SHSFSDPSPKFAHH----------HLRSQDPCPPSR 666
Query: 327 ---TSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSP-------GVRQPGSSSS 376
S S KS +K+ S P V ++SP ++ G +S
Sbjct: 667 SEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQGSGQQNS 726
Query: 377 SAPGQPSTGVARPTV----SSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGT 432
A + ST P + VPR +GSSS S SGS+ S+P ++ SG
Sbjct: 727 QAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGS---SNSGSQP---GSHPGSQSGSGE 780
Query: 433 CGPGQPAS-SSGGPGRPISGSVSSARPLGSSRGPGRP-----VSSPHELRRPVSGLGPPG 486
+ +S S G P + + +V P +P +++ + R V + PP
Sbjct: 781 RFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPH 840
Query: 487 RSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQTVS------SSGPTIKPKCTVVSE 540
+ S G S+ GP T + S+G T K +V +
Sbjct: 841 KVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHD 900
Query: 541 TISSKNIISRSSNGQM 556
+ S+ ++ S G +
Sbjct: 901 DVESEPAMTPSKEGTL 916
Score = 58.5 bits (140), Expect = 2e-08
Identities = 92/452 (20%), Positives = 172/452 (38%), Gaps = 23/452 (5%)
Query: 28 GPPKKDPKVKGVQSAAVQAFLKRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAK 87
G P V G +S + FL+ ++E R E RR++ L ++++ + + K + +A+
Sbjct: 338 GEPSSIVNVPG-ESTLRRDFLRLQQENKERS--EALRRQQLLQEQQLREQEEYKRQLLAE 394
Query: 88 RTK--DNFHGYNGIPIEEKSKKRQATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEE 145
R K + E++ ++R+A + RE E + E LE E E+
Sbjct: 395 RQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRA 454
Query: 146 EQEPPKVESKPKVPLKSAPPPMNFTDLLR---LAEKKQFEPVEIKVVKKSEERPMTAEEL 202
E+E +VE + + + ++L+ L E+ + +++ + +L
Sbjct: 455 EEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQL 514
Query: 203 RERE----FLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPL 258
++ + L+ HRR + + PP +++ + K DR +
Sbjct: 515 QQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDR-F 573
Query: 259 PHAEKKSRPSMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPV-FNGAGKPHS 317
S + + + L E G+ S P+L+ + V ++ +
Sbjct: 574 RKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKN 633
Query: 318 STSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSS 377
+ S S + + + K A H + PS S + +K+++P Q S S
Sbjct: 634 NVSPVSRSHSFSDPSPKFAHHHLRSQDPCPPSRSEVLSQ-SSDSKSEAPDPTQKAWSRSD 692
Query: 378 APGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPS---RRTVSGTCG 434
+ P R T S + RR + SG + S +G + T+ P R
Sbjct: 693 SDEVPPRVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPR 752
Query: 435 PGQPASSSGGPGRPISGSVSSARPLGSSRGPG 466
PG +SS G SGS + P GS G G
Sbjct: 753 PGSGSSS----GSSNSGSQPGSHP-GSQSGSG 779
Score = 41.6 bits (96), Expect = 0.002
Identities = 44/169 (26%), Positives = 73/169 (43%), Gaps = 31/169 (18%)
Query: 545 KNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTGYKRQREYE-EEDDDDDEY---DSE 600
KN + R S Q+ +K P + + R+ R R+ E+D+ + EY + E
Sbjct: 272 KNYMQRPSTEQL--LKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEE 329
Query: 601 MEDFIEDEGEPQ----------------------EEISKHIREIFGYDRKKYKDESDYAL 638
E+ E EGEP +E S+ +R ++ +++ +Y
Sbjct: 330 EEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKR 389
Query: 639 RYMESSWK--EQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR 685
+ + K EQQKE+ + L Q E RR++E QRRR ++ KRR
Sbjct: 390 QLLAERQKRIEQQKEQRRRLE-EQQRREREARRQQEREQRRREQEEKRR 437
Score = 34.3 bits (77), Expect = 0.39
Identities = 23/95 (24%), Positives = 45/95 (47%), Gaps = 3/95 (3%)
Query: 120 DREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLRLAEKK 179
DR + E + EY ++ SE EEE+E P+ E +P + D LRL ++
Sbjct: 307 DRTRKKRGEKDETEYEYSGSE---EEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQEN 363
Query: 180 QFEPVEIKVVKKSEERPMTAEELREREFLERKHRR 214
+ ++ + +E+ + +E +R+ L + +R
Sbjct: 364 KERSEALRRQQLLQEQQLREQEEYKRQLLAERQKR 398
>gi|158854042 hypothetical protein LOC222183 [Homo sapiens]
Length = 653
Score = 58.5 bits (140), Expect = 2e-08
Identities = 93/392 (23%), Positives = 141/392 (35%), Gaps = 68/392 (17%)
Query: 192 SEERPMTAEELREREFLERKHRRKKLETDGKLPPTVSKKAPSQKESVGTKLSKGSGDRHP 251
S P ++ +++ R ++++LE++ + +P +K+ K K DR
Sbjct: 162 SSASPPPKKKKKKKGGHRRSRKKRRLESEC----SCGSSSPLRKKKKSVK--KHRRDRSD 215
Query: 252 SSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGERI-KAGSGNSSQPSLREGHD----- 305
S H + S+ + PG R + SG+S PSL +
Sbjct: 216 SGSRRKRRHRSRSSKCKRKEKNKEKKRPHTESPGRRSHRHSSGSSHSPSLSSHYSDSRSP 275
Query: 306 ---KPVFNGAGKPHSS--TSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPH 360
P G+ S +S P S S + S RPG +P
Sbjct: 276 SRLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSGQRSGAHGGRPGSAHSPP 335
Query: 361 NKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVP--------------------RRQ 400
+K SP R ++++AP P+ G P+ S P RR+
Sbjct: 336 DKPSSPSPRVRDKAAAAAPTPPARGKESPSPRSAPSSQGRGGRAAGGAGRRRRRRRRRRR 395
Query: 401 NGSSSSGPER---------SISGSKKPTNDSNPSRRTVSGTCGPG---QPAS--SSGGPG 446
+ SS+S P R GS + + + S + SG PG +P S GG G
Sbjct: 396 SRSSASAPRRRGRRRPRPAPPRGSSRSLSRARSSSDSGSGRGAPGPGPEPGSERGHGGHG 455
Query: 447 RPISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVS-GPG---RSISGSIPA 502
+ ARP +S PG H R GP G+S S PG RS S S
Sbjct: 456 KRAKERPPRARPASTSPSPG-----AHGRRG-----GPEGKSSSRSPGPHPRSWSSSRSP 505
Query: 503 GRTVSNSVPGRPVSSLGPGQTVSSSGPTIKPK 534
++ S S RP S P ++ S P + K
Sbjct: 506 SKSRSRSAEKRPHS---PSRSPSPKKPLSRDK 534
Score = 38.5 bits (88), Expect = 0.021
Identities = 51/217 (23%), Positives = 80/217 (36%), Gaps = 22/217 (10%)
Query: 228 SKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSSSKSMPGER 287
+K+ P + T S G+ R +G KS + SSS+S R
Sbjct: 458 AKERPPRARPASTSPSPGAHGRRGGPEG--------KSSSRSPGPHPRSWSSSRSPSKSR 509
Query: 288 IKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSH 347
++ PS KP+ K + S + + +R + + K+
Sbjct: 510 SRSAEKRPHSPSRSPSPKKPL--SRDKDGEGRARHSEAEATRARRRSRSYSPIRKRRRDS 567
Query: 348 PSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSG 407
PS P +T K P R SSSSS S+ + + S P P +GS SS
Sbjct: 568 PSFMEPR-RITSARKRPIPYYRPSPSSSSSCL---SSDYSTRSHSRSPSPGHSHGSYSSR 623
Query: 408 PERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGG 444
+ S ++ P+ +PS + S +S SGG
Sbjct: 624 SHGTRSRTRSPSRTPSPSYHSRS--------SSESGG 652
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 58.2 bits (139), Expect = 3e-08
Identities = 99/451 (21%), Positives = 171/451 (37%), Gaps = 80/451 (17%)
Query: 49 KRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKR 108
K + E LRR+ LE+++R+ E K+++ + K+ IEE+ ++R
Sbjct: 362 KERSEALRRQQLEQQQRENEEHKRQLLAERQKR-------------------IEEQKEQR 402
Query: 109 QATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMN 168
+ E RE E+ ++ E + H E + EEE+
Sbjct: 403 RRLEEQQR----REKELRKQQEREQRRHYEEQMRREEER--------------------- 437
Query: 169 FTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPTVS 228
R AE +Q E + ++ ++ + + ++L + L +++RK+LE +
Sbjct: 438 -----RRAEHEQ-EYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERL-- 489
Query: 229 KKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEK----KSRPSMANE-KHLALSSSKSM 283
++ Q+ L ++ P K PL H ++ +P+ A E HL S+
Sbjct: 490 QRQLKQERDYLVSLQHQRQEQRPVEK-KPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQ-- 546
Query: 284 PGERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKK 343
G + A QP+ + N S P TS + + +E +
Sbjct: 547 -GPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDP-TSENPPLPTRIEKFDRS 604
Query: 344 SLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGS 403
S P P V + SP + + S + + P G ++P +S P RR
Sbjct: 605 SWLRQEEDIP-PKVPQRTTSISPALARKNSPGNGSALGPRLG-SQPIRASNPDLRRTEPI 662
Query: 404 SSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSR 463
S +R+ SGS ++ S PS QP+S G +GS R +S+
Sbjct: 663 LESPLQRTSSGSS--SSSSTPS----------SQPSSQGGSQPGSQAGSSERTRVRANSK 710
Query: 464 GPGRPVSSPHELRRPVSGLGPPGRSVSGPGR 494
G PV PHE P R ++ P R
Sbjct: 711 SEGSPV-LPHE---PAKVKPEESRDITRPSR 737
Score = 44.3 bits (103), Expect = 4e-04
Identities = 84/417 (20%), Positives = 161/417 (38%), Gaps = 45/417 (10%)
Query: 48 LKRKEEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEE---- 103
L++++E +R+ EE+ R+EE ++R E + + R + + + + E+
Sbjct: 415 LRKQQEREQRRHYEEQMRREE-ERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLL 473
Query: 104 KSKKRQATESHTSQGTDREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKP----KVP 159
+ K++Q E ++ R+ + E + + S Q +EQ P VE KP K
Sbjct: 474 EYKRKQLEEQRQAERLQRQLKQERD-------YLVSLQHQRQEQRP--VEKKPLYHYKEG 524
Query: 160 LKSAPPPMNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFLERKHRRKKLET 219
+ + P ++ L K P + + E+P T +E L R ++
Sbjct: 525 MSPSEKPAWAKEIPHLVAVKSQGPA-LTASQSVHEQP-TKGLSGFQEALNVTSHRVEMPR 582
Query: 220 DGKLPPTVSKKAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEKKSRPSMANEKHLALSS 279
P + + P++ E K + S R +P P++A +
Sbjct: 583 QNSDPTSENPPLPTRIE----KFDRSSWLRQEEDIPPKVPQRTTSISPALARKNS---PG 635
Query: 280 SKSMPGERIKAGSGNSSQPSLREGH---DKPVFNGAGKPHSSTSSPSVPKTSASRTQKSA 336
+ S G R+ + +S P LR + P+ + SS+S+PS +S +Q +
Sbjct: 636 NGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGS 695
Query: 337 VEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVA--------R 388
++++ + G V PH AK V+ S + P +P+ A R
Sbjct: 696 QAGSSERTRVRANSKSEGSPVLPHEPAK---VKPEESRDITRPSRPADLTALAKELRELR 752
Query: 389 PTVSSGPVPRRQNGSSSS----GPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASS 441
++ P+ + + SSSS E + T+D + + G P S+
Sbjct: 753 IEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN 809
Score = 37.0 bits (84), Expect = 0.061
Identities = 108/525 (20%), Positives = 185/525 (35%), Gaps = 87/525 (16%)
Query: 120 DREYEMEEENEFLEYNHAESEQEYEEEQEPPKVESKPKVPLKSAPPPMNFTDLLR--LAE 177
DR + E + EY ++ SE+E EEE + + S +P +S D LR LA
Sbjct: 307 DRTKKKRGEKDETEYEYSGSEEE-EEENDSGEPSSILNLPGESTLR----RDFLRLQLAN 361
Query: 178 KKQFEPVEIKVVKKSE------ERPMTAEELREREFLERKHRRKKLETDGKLPPTVSK-- 229
K++ E + + +++ + +R + AE R++ E+K +R++LE + + K
Sbjct: 362 KERSEALRRQQLEQQQRENEEHKRQLLAE--RQKRIEEQKEQRRRLEEQQRREKELRKQQ 419
Query: 230 -------------------KAPSQKESVGTKLSKGSGDRHPSSKGMPLPHAEK---KSRP 267
+A ++E + +L + R L H + + +
Sbjct: 420 EREQRRHYEEQMRREEERRRAEHEQEYIRRQLEE--EQRQLEILQQQLLHEQALLLEYKR 477
Query: 268 SMANEKHLALSSSKSMPGERIKAGSGNSSQPSLREGHDKPVFN---GAGKPHSSTSSPSV 324
E+ A + + ER S + R KP+++ G + +
Sbjct: 478 KQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEI 537
Query: 325 PKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKA---KSPGVRQPGSSSSSAPGQ 381
P A ++Q A+ + S H +P ++ +A S V P +S
Sbjct: 538 PHLVAVKSQGPAL------TASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSEN 591
Query: 382 PSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASS 441
P R++ P+R+ S S ++P + G QP +
Sbjct: 592 PPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRA 651
Query: 442 SGGPGR---PISGSVSSARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSISG 498
S R PI S GSS P S P G PG S +G
Sbjct: 652 SNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSS-----QGGSQPG--------SQAG 698
Query: 499 SIPAGRTVSNS-VPGRPVSSLGPGQTVSSSGPTIKPKCTVVSETISSKNIISRSSNGQMN 557
S R +NS G PV P + +KP+ S++I S +
Sbjct: 699 SSERTRVRANSKSEGSPVLPHEPAK--------VKPE--------ESRDITRPSRPADLT 742
Query: 558 GMKPPLSGYRAAQGPQRLPFPTGYKRQREYEEEDDDDDEYDSEME 602
+ L R + + + T Y E E E +++E D E E
Sbjct: 743 ALAKELRELRIEETNRPMKKVTDYSSSSE-ESESSEEEEEDGESE 786
Score = 30.8 bits (68), Expect = 4.3
Identities = 25/106 (23%), Positives = 54/106 (50%), Gaps = 5/106 (4%)
Query: 582 KRQREYEEEDDDDDEYDSEMEDFIEDEGEPQEEISKHIREIF--GYDRKKYKDESDYALR 639
+RQ+ EE+ + + + E + + E +H E +R++ + E +Y R
Sbjct: 390 ERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRR 449
Query: 640 YMESSWKEQQKEEAKSLRLGMQEDLEEMRREEEEMQRRRAKKLKRR 685
+E +++Q E + L Q L E +R++ E ++R+A++L+R+
Sbjct: 450 QLEE--EQRQLEILQQQLLHEQALLLEYKRKQLE-EQRQAERLQRQ 492
>gi|50843820 sickle tail isoform 1 [Homo sapiens]
Length = 1943
Score = 58.2 bits (139), Expect = 3e-08
Identities = 109/460 (23%), Positives = 183/460 (39%), Gaps = 34/460 (7%)
Query: 52 EEELRRKALEEKRRKEELVKKRIELKHDKKARAMAKRTKDNFHGYNGIPIEEKSKKRQ-A 110
+EEL R +EEK +EE + + + M+ + + G +E KS+ A
Sbjct: 1468 DEELERMMMEEKIEEEEEEENGDSVVQNNNTSQMSHKKVAPGNLRTGQQVETKSQPHSLA 1527
Query: 111 TESHTSQGTDREYEMEEENEFLEYNHAESEQEYE----EEQEPPKVESKPKVPLKSAPPP 166
TE+ G +E E N+F + SE + E ++ E PK + K K P K
Sbjct: 1528 TETRNPGG--QEMNRTELNKFSHVDSPNSECKGEDATDDQFESPKKKFKFKFPKKQLAA- 1584
Query: 167 MNFTDLLRLAEKKQFEPVEIKVVKKSEERPMTAEELREREFLERKHRRKKLETDGKLPPT 226
T +R K + +++ VV + EE T ++ +E + E + + + T
Sbjct: 1585 --LTQAIRTGTKTGKKTLQV-VVYEEEEEDGTLKQHKEAKRFEIARSQPEDTPEN----T 1637
Query: 227 VSKKAPSQKESVGTKLSKGSGDRHPSSKGM-PLPHAEKKSRPSMANEKHLALSSSKSMPG 285
V ++ ES + +S+ R + + + L K+ +++ AL +
Sbjct: 1638 VRRQEQPSIEST-SPISRTDEIRKNTYRTLDSLEQTIKQLENTISEMSPKALVDTSCSSN 1696
Query: 286 ERIKAGSGNSSQPSLREGHDKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSL 345
A S + +Q E +P+ P + S+P SASR S ++ +
Sbjct: 1697 RDSVASSSHIAQ----EASPRPLLVPDEGPTALEPPTSIP--SASRKGSSGAPQTSRMPV 1750
Query: 346 SHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSS 405
+ +RPG + P ++K RQ ++ SA + S G +PT S P + S S
Sbjct: 1751 PMSAKNRPGTLDKPGKQSKLQDPRQYRQANGSA--KKSGGDFKPTSPSLPASKIPALSPS 1808
Query: 406 SGPERSI-SGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSS-- 462
SG S+ S S +N NP S P P + + SVS+ S
Sbjct: 1809 SGKSSSLPSSSGDSSNLPNPPATKPSIASNPLSPQTGPPAHSASLIPSVSNGSLKFQSLT 1868
Query: 463 -RGPGRPVS-SPHELRRPVSGLGPPGRSVSGPGRSISGSI 500
G G +S SP + +G PP S S S + S+
Sbjct: 1869 HTGKGHHLSFSP----QSQNGRAPPPLSFSSSPPSPASSV 1904
Score = 29.6 bits (65), Expect = 9.7
Identities = 42/188 (22%), Positives = 73/188 (38%), Gaps = 13/188 (6%)
Query: 248 DRHPSSKGMP-LPHAEKKSRPSMANEKHLALSSSKSMPGERIKA--GSGNSSQPSLREGH 304
+ + S K P LP++ + + + +L ++S + R K +GNS +
Sbjct: 2 EENESQKCEPCLPYSADRRQMQEQGKGNLHVTSPEDAECRRTKERLSNGNSRGSVSKSSR 61
Query: 305 DKPVFNGAGKPHSSTSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVTPHNKAK 364
+ P + G P SS + + R +++ +EH +K +P H+ + H +
Sbjct: 62 NIPRRHTLGGPRSSKEILGMQTSEMDRKREAFLEHLKQK---YPHHA---SAIMGHQERL 115
Query: 365 SPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKPTNDSNP 424
R P S S P PS G +S + S P GS+ T S P
Sbjct: 116 RDQTRSPKLSHSPQP--PSLGDPVEHLSETSADSLEAMSEGDAPTPFSRGSR--TRASLP 171
Query: 425 SRRTVSGT 432
R+ + T
Sbjct: 172 VVRSTNQT 179
>gi|19924099 synapsin I isoform Ia [Homo sapiens]
Length = 705
Score = 57.8 bits (138), Expect = 3e-08
Identities = 57/211 (27%), Positives = 77/211 (36%), Gaps = 29/211 (13%)
Query: 337 VEHKAKKSLSHPSHSRPGPMVTPHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSS--- 393
V +K ++L P H + SPG G +S P P P
Sbjct: 410 VVNKMAQALPRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQ 469
Query: 394 -GPVPRRQNGSSSSGP----ERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGP--- 445
GP P+RQ P ++ +SG P P +R S T P QPAS + P
Sbjct: 470 PGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLP-QRLPSPTSAPQQPASQAAPPTQG 528
Query: 446 ----GRPISGSVSS---ARPLGSSRGPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSISG 498
RP++G + ARP +S P R P R+ SVSGP +
Sbjct: 529 QGRQSRPVAGGPGAPPAARP-PASPSPQRQAGPPQATRQ---------TSVSGPAPPKAS 578
Query: 499 SIPAGRTVSNSVPGRPVSSLGPGQTVSSSGP 529
P G P +P GP + S +GP
Sbjct: 579 GAPPGGQQRQGPPQKPPGPAGPTRQASQAGP 609
Score = 53.1 bits (126), Expect = 8e-07
Identities = 50/186 (26%), Positives = 64/186 (34%), Gaps = 14/186 (7%)
Query: 348 PSHSRPGPMVTPHNKAKSPGVRQPGS----SSSSAPGQPSTGVARPTVSSGPVPRRQNGS 403
P RP P H P P S +SAP QP++ A PT G R G
Sbjct: 480 PLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGG 539
Query: 404 SSSGPERSISGSKKPTNDSNPSRRTVSGTCGPGQPASSSGGPGRPISGSVSSARPLGSSR 463
+ P S P + P + T + P +SG P G P
Sbjct: 540 PGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAP----PGGQQRQGPPQKPP 595
Query: 464 GPGRPVSSPHELRRPVSGLGPPGRSVSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPGQT 523
GP P + PV GPP P SG PAGR + +P + P T
Sbjct: 596 GPAGPTRQASQ-AGPVPRTGPPTTQQPRP----SGPGPAGRP-KPQLAQKPSQDVPPPAT 649
Query: 524 VSSSGP 529
++ GP
Sbjct: 650 AAAGGP 655
Score = 38.5 bits (88), Expect = 0.021
Identities = 46/184 (25%), Positives = 69/184 (37%), Gaps = 25/184 (13%)
Query: 421 DSNPSRRTVSGTCGPG----------QPASSSGGPGRPISGSVSSARPLGSSRGPGRPVS 470
D++P R + T PG QPA P G P +GP
Sbjct: 425 DASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQR 484
Query: 471 SPHELRRPVSGLGPPGRS---------VSGPGRSISGSIPAGRTVSNSVPGRPVSSLGPG 521
P + ++ +SGLGPP S S P + S + P T RPV+ GPG
Sbjct: 485 PPPQGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPP--TQGQGRQSRPVAG-GPG 541
Query: 522 QTVSSSGP-TIKPKCTVVSETISSKNIISRSSNGQMNGMKPPLSGYRAAQGPQRLPFPTG 580
++ P + P+ + + +S + + +G P G + PQ+ P P G
Sbjct: 542 APPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASGAPP--GGQQRQGPPQKPPGPAG 599
Query: 581 YKRQ 584
RQ
Sbjct: 600 PTRQ 603
Score = 33.1 bits (74), Expect = 0.88
Identities = 39/185 (21%), Positives = 67/185 (36%), Gaps = 10/185 (5%)
Query: 247 GDRHPSSKGMPL--PHAEKKSRPSMANEKHLALSSSKSMPGERIK--AGSGNSSQPSLRE 302
G +H S G P P ++ P+ A ++ + ++ + R G + P+ R
Sbjct: 489 GQQHLSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARP 548
Query: 303 GHDKPVFNGAGKPHS----STSSPSVPKTSASRTQKSAVEHKAKKSLSHPSHSRPGPMVT 358
AG P + S S P+ PK S + + +K +R
Sbjct: 549 PASPSPQRQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAG 608
Query: 359 PHNKAKSPGVRQPGSSSSSAPGQPSTGVARPTVSSGPVPRRQNGSSSSGPERSISGSKKP 418
P + P +QP S G+P +A+ S VP ++ P ++ S+
Sbjct: 609 PVPRTGPPTTQQPRPSGPGPAGRPKPQLAQK--PSQDVPPPATAAAGGPPHPQLNKSQSL 666
Query: 419 TNDSN 423
TN N
Sbjct: 667 TNAFN 671
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.125 0.346
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,986,816
Number of Sequences: 37866
Number of extensions: 2051799
Number of successful extensions: 26672
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 382
Number of HSP's successfully gapped in prelim test: 2180
Number of HSP's that attempted gapping in prelim test: 12657
Number of HSP's gapped (non-prelim): 10761
length of query: 685
length of database: 18,247,518
effective HSP length: 109
effective length of query: 576
effective length of database: 14,120,124
effective search space: 8133191424
effective search space used: 8133191424
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.