Guide to the Human Genome
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Search of human proteins with 51479158

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|51479158 ataxin 1 [Homo sapiens]
         (815 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189491748 ataxin 1 [Homo sapiens]                                 1634   0.0  
gi|51479158 ataxin 1 [Homo sapiens]                                  1634   0.0  
gi|212549561 ataxin 1-like [Homo sapiens]                             257   3e-68
gi|55750053 atrophin-1 [Homo sapiens]                                  74   4e-13
gi|55750041 atrophin-1 [Homo sapiens]                                  74   4e-13
gi|4507379 TATA box binding protein [Homo sapiens]                     70   1e-11
gi|110347429 mediator complex subunit 12 [Homo sapiens]                66   1e-10
gi|56549696 E1A binding protein p400 [Homo sapiens]                    65   3e-10
gi|93141033 PAX interacting protein 1 [Homo sapiens]                   65   3e-10
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]    64   6e-10
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]    64   6e-10
gi|17017963 forkhead box P2 isoform I [Homo sapiens]                   64   7e-10
gi|22538413 forkhead box P2 isoform III [Homo sapiens]                 62   2e-09
gi|149999352 forkhead box P2 isoform II [Homo sapiens]                 62   2e-09
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]       62   2e-09
gi|33286444 mastermind-like 2 [Homo sapiens]                           62   3e-09
gi|55956910 meningioma  1 [Homo sapiens]                               62   3e-09
gi|38158015 mastermind-like 3 [Homo sapiens]                           62   3e-09
gi|38787935 BMP-2 inducible kinase isoform a [Homo sapiens]            60   1e-08
gi|38787904 BMP-2 inducible kinase isoform b [Homo sapiens]            60   1e-08
gi|239757877 PREDICTED: FERM and PDZ domain containing 3 [Homo s...    59   1e-08
gi|89060961 PREDICTED: FERM and PDZ domain containing 3 [Homo sa...    59   1e-08
gi|89059963 PREDICTED: FERM and PDZ domain containing 3 [Homo sa...    59   1e-08
gi|157743257 POU domain, class 6, transcription factor 2 [Homo s...    59   1e-08
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    57   5e-08
gi|40354197 THAP domain containing 11 [Homo sapiens]                   57   7e-08
gi|32307128 nuclear receptor coactivator 6 [Homo sapiens]              57   7e-08
gi|51702521 POU domain, class 3, transcription factor 2 [Homo sa...    56   1e-07
gi|10863899 numb homolog (Drosophila)-like [Homo sapiens]              56   1e-07
gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]       56   2e-07

>gi|189491748 ataxin 1 [Homo sapiens]
          Length = 815

 Score = 1634 bits (4230), Expect = 0.0
 Identities = 815/815 (100%), Positives = 815/815 (100%)

Query: 1   MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRH 60
           MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRH
Sbjct: 1   MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRH 60

Query: 61  GPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQY 120
           GPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQY
Sbjct: 61  GPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQY 120

Query: 121 AHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTL 180
           AHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTL
Sbjct: 121 AHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTL 180

Query: 181 LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPP 240
           LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPP
Sbjct: 181 LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPP 240

Query: 241 PAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHF 300
           PAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHF
Sbjct: 241 PAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHF 300

Query: 301 VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRH 360
           VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRH
Sbjct: 301 VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRH 360

Query: 361 VVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGK 420
           VVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGK
Sbjct: 361 VVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGK 420

Query: 421 PGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQ 480
           PGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQ
Sbjct: 421 PGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQ 480

Query: 481 HLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVT 540
           HLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVT
Sbjct: 481 HLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVT 540

Query: 541 QAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQ 600
           QAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQ
Sbjct: 541 QAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQ 600

Query: 601 SAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSC 660
           SAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSC
Sbjct: 601 SAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSC 660

Query: 661 CPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSR 720
           CPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSR
Sbjct: 661 CPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSR 720

Query: 721 HRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESR 780
           HRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESR
Sbjct: 721 HRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESR 780

Query: 781 KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK 815
           KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
Sbjct: 781 KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK 815


>gi|51479158 ataxin 1 [Homo sapiens]
          Length = 815

 Score = 1634 bits (4230), Expect = 0.0
 Identities = 815/815 (100%), Positives = 815/815 (100%)

Query: 1   MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRH 60
           MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRH
Sbjct: 1   MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRH 60

Query: 61  GPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQY 120
           GPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQY
Sbjct: 61  GPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQY 120

Query: 121 AHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTL 180
           AHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTL
Sbjct: 121 AHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTL 180

Query: 181 LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPP 240
           LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPP
Sbjct: 181 LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPP 240

Query: 241 PAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHF 300
           PAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHF
Sbjct: 241 PAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHF 300

Query: 301 VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRH 360
           VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRH
Sbjct: 301 VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRH 360

Query: 361 VVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGK 420
           VVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGK
Sbjct: 361 VVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGK 420

Query: 421 PGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQ 480
           PGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQ
Sbjct: 421 PGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQ 480

Query: 481 HLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVT 540
           HLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVT
Sbjct: 481 HLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVT 540

Query: 541 QAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQ 600
           QAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQ
Sbjct: 541 QAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQ 600

Query: 601 SAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSC 660
           SAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSC
Sbjct: 601 SAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSC 660

Query: 661 CPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSR 720
           CPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSR
Sbjct: 661 CPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSR 720

Query: 721 HRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESR 780
           HRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESR
Sbjct: 721 HRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESR 780

Query: 781 KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK 815
           KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
Sbjct: 781 KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK 815


>gi|212549561 ataxin 1-like [Homo sapiens]
          Length = 689

 Score =  257 bits (657), Expect = 3e-68
 Identities = 248/843 (29%), Positives = 349/843 (41%), Gaps = 182/843 (21%)

Query: 1   MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNP-GGRGHGGGR 59
           MK   ERS ECLPPKKR++P TS           +     + + W  G    G+   G R
Sbjct: 1   MKPVHERSQECLPPKKRDLPVTSEDMGRTTSCSTNHTPSSDASEWSRGVVVAGQSQAGAR 60

Query: 60  HGPAGTSVE----LGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLP----AAYATPQP 111
               G   E    L + Q   L+K       +SP   P  V ++   P    A+     P
Sbjct: 61  VSLGGDGAEAITGLTVDQYGMLYKVAVPPATFSPTGLPSVVNMSPLPPTFNVASSLIQHP 120

Query: 112 GTPVSPVQYAHLPHT-FQFIGSSQYSGTYA---SFIPSQLIPPTANPVTSAVASAAGATT 167
           G    P+ YA LP T  QFIGS  YS  YA   +F+PS L+ P+AN  TS +        
Sbjct: 121 GIHYPPLHYAQLPSTSLQFIGSP-YSLPYAVPPNFLPSPLLSPSANLATSHLP------- 172

Query: 168 PSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHL 227
                    Y++LLA       TP  +A                                
Sbjct: 173 -----HFVPYASLLAE----GATPPPQAPSPAHS-------------------------F 198

Query: 228 SRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPS 287
           ++AP   +P    P       H S+ P +     +P  +P++    +    +TL   PP 
Sbjct: 199 NKAPSATSPSGQLPH------HSSTQPLDL----APGRMPIYYQMSRLPAGYTLHETPP- 247

Query: 288 QVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKA 347
                 A +     P+E+    E++      + +E  N    +S    +P+S   G G  
Sbjct: 248 ------AGASPVLTPQESQSALEAAAANGGQRPRE-RNLVRRESEALDSPNSKGEGQGL- 299

Query: 348 GGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQ-------- 399
               VP        VV               R  V    +  TP  DLEVQ+        
Sbjct: 300 ----VP--------VVECVVDGQLFSGSQTPRVEVAAPAHRGTPDTDLEVQRVVGALASQ 347

Query: 400 -----ATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATA-- 452
                A  R+  PS LN    L    P H+          +   SA  P  +   + A  
Sbjct: 348 DYRVVAAQRKEEPSPLN----LSHHTPDHQG---------EGRGSARNPAELAEKSQARG 394

Query: 453 FYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSS 512
           FY  +    + +    +  +   G+L    V  GT   L+PVGS  + AS          
Sbjct: 395 FYPQSHQEPVKHRPLPKAMVVANGNL----VPTGTDSGLLPVGSEILVASSLD------- 443

Query: 513 PQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPP 572
                                              VQA+   P  +    P  +   LP 
Sbjct: 444 -----------------------------------VQARATFPDKEPTPPPITSSH-LPS 467

Query: 573 YFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFA 632
           +FMKG+IIQLA GELK+VEDL+T+DF++SAE+S  LKIDSSTV  I++S  PG  ++ F 
Sbjct: 468 HFMKGAIIQLATGELKRVEDLQTQDFVRSAEVSGGLKIDSSTVVDIQESQWPGFVMLHFV 527

Query: 633 VGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKN 692
           VGE +++VS+EV  E+PFFV+GQGWSSC P RT+QLF LPC +L VGDVCIS++L++L +
Sbjct: 528 VGEQQSKVSIEVPPEHPFFVYGQGWSSCSPGRTTQLFSLPCHRLQVGDVCISISLQSLNS 587

Query: 693 GSVKKGQPVDPASVLLKHSKADGLAGSRHRYAEQENGINQGSAQMLSENGELKFPEKMGL 752
            SV +     P+           L   R    E+      GS ++    G+ +       
Sbjct: 588 NSVSQASCAPPSQ----------LGPPR----ERPERTVLGSRELCDSEGKSQ------- 626

Query: 753 PAAPFLTKIEPSKPAATRKRRWSAPESRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSN 812
           PA      +EPS+P +  +  W AP  ++     +E    L +PS IPQEVK+ IEGRSN
Sbjct: 627 PAGEGSRVVEPSQPESGAQACWPAPSFQRYSMQGEEARAALLRPSFIPQEVKLSIEGRSN 686

Query: 813 VGK 815
            GK
Sbjct: 687 AGK 689


>gi|55750053 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 128/525 (24%), Positives = 180/525 (34%), Gaps = 96/525 (18%)

Query: 13  PPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGTSVELGLQ 72
           PP K   P T+       P+ P   +    T  LP  P  R        P G   +  L 
Sbjct: 271 PPTK---PPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQ-PLP 326

Query: 73  QGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGS 132
             +    A+  G+   PP  P   P     P +        P  P+++ +   +     +
Sbjct: 327 GHLPSPHAMGQGMGGLPPG-PEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAA 385

Query: 133 SQYSGTYAS----FIPSQLIP--------PTANPVTSAVASAAGATTPSQRSQLEA---- 176
           S  S + +S    F  SQ +P        PT+  V++        + PSQ    +     
Sbjct: 386 SSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPP 445

Query: 177 --YSTLLANMGSL---------SQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQ 225
             Y  LLAN  +          +Q+  H          QQQQQ Q  QQQQQQQQQQQQ 
Sbjct: 446 PPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQ--QQQQQQQQQQQQH 503

Query: 226 HLSRAPGLITPGS-PPPAQ--QNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLT 282
           H +  P    PG+ P P +   + + H  +   + G     P  P HL P          
Sbjct: 504 HGNSGPP--PPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPP---------- 551

Query: 283 LGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAP----- 337
             P SQV   Y+ +G +  P  ++  + SS  Q +         +  +   Y  P     
Sbjct: 552 --PHSQV--SYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTV 607

Query: 338 --SSADLGL-------GKAGGKSV----PHPYESRHVVVHPSPSDYSSRDPSGVRASVMV 384
             SSA L           AG K+     P PY  R     PSP  Y +  P G +     
Sbjct: 608 TTSSATLSTVIATVASSPAGYKTASPPGPPPYGKR----APSPGAYKTATPPGYKPGSPP 663

Query: 385 LPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPL 444
              + TP       + T   A P T          KPG  +    P      +   S P 
Sbjct: 664 SFRTGTPPG----YRGTSPPAGPGTF---------KPGSPTVGPGPLPPAGPSGLPSLPP 710

Query: 445 PVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQP 489
           P   PA+       PP+      Q+ A  Y    P+  V P   P
Sbjct: 711 PPAAPASG------PPLSATQIKQEPAEEY--ETPESPVPPARSP 747



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 125/579 (21%), Positives = 170/579 (29%), Gaps = 115/579 (19%)

Query: 50  PGGRGH--GGGRHGPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYA 107
           PGG G    G   GP G     G    +G     + G  + PP+ P SV  +     A  
Sbjct: 221 PGGTGGVLSGPPMGPKGG----GAASSVG---GPNGGKQHPPPTTPISVSSS----GASG 269

Query: 108 TPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAG--- 164
            P    P +PV   +LP       S+     +    P+   PP   P+ +A AS  G   
Sbjct: 270 APPTKPPTTPVGGGNLP-------SAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGA 322

Query: 165 -------------------------------------------ATTPSQRSQLEAYSTLL 181
                                                      A  P  R    + S+  
Sbjct: 323 QPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSS 382

Query: 182 ANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQ-----QQQQQQQQQQQQQHLSRAPGLITP 236
           A   S S +    A      Q      H            Q  +  Q    S+A     P
Sbjct: 383 AAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGP 442

Query: 237 GSPPPAQQ---NQYVHISSSPQNTG--RTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVM 291
             PPP  +   N   H    P +TG   TA PP +  H H HQ             Q   
Sbjct: 443 PPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPP-VSTHHHHHQQQQQQQQQQQQQQQQQQ 501

Query: 292 QYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYG------APSSADLGLG 345
           Q+  +     P       E      A      ++  +   R Y        P  + +   
Sbjct: 502 QHHGNSGPPPPGAFPHPLEGGSSHHA--HPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYS 559

Query: 346 KAGGKSVPHPYESR---------HVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLE 396
           +AG    P    S          +   HPSP    S+ P G       +P   T +A L 
Sbjct: 560 QAGPNGPPVSSSSNSSSSTSQGSYPCSHPSP----SQGPQGAPYPFPPVPTVTTSSATLS 615

Query: 397 VQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAG 456
              AT    + S    K+    G P +   A SP      T    +P   G P  +F  G
Sbjct: 616 TVIAT---VASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKP---GSP-PSFRTG 668

Query: 457 TQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFA 516
           T P   GY      A           V PG  P   P G + + +    PA   S P  +
Sbjct: 669 TPP---GYRGTSPPAGPGTFKPGSPTVGPGPLP---PAGPSGLPSLPPPPAAPASGPPLS 722

Query: 517 AVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLP 555
           A          P  E   PE+ V  A  P+     + +P
Sbjct: 723 ATQ----IKQEPAEEYETPESPVPPARSPSPPPKVVDVP 757



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 92/430 (21%), Positives = 161/430 (37%), Gaps = 86/430 (20%)

Query: 89   PPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIP--SQ 146
            PP+ P  +P   +LP   A P  G P+S  Q    P       + +Y    +   P  S 
Sbjct: 698  PPAGPSGLP---SLPPPPAAPASGPPLSATQIKQEP-------AEEYETPESPVPPARSP 747

Query: 147  LIPPTANPVTSAVASAAGATTPSQR-----SQLEAY------STLLANMGSLSQTPGHKA 195
              PP    V S  + +A       R     ++ + Y      S L      L +    +A
Sbjct: 748  SPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREA 807

Query: 196  EQQ-----QQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSP----PPAQQNQ 246
            EQ+     ++++++++++ + ++++++ ++  +     RAP       P    PP +   
Sbjct: 808  EQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGS 867

Query: 247  YVHISSSPQNTG------RTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQY------- 293
             V  ++ P   G      RT S  A P  + P     P  + LG     ++ Y       
Sbjct: 868  AV--ATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYS 925

Query: 294  ADSGSHFVPREATKKAESSRLQQAIQAK----EVLNG----EMEKSRRYGAPSSADLGLG 345
            +D  +    REA ++    RL+   + K    E L+G     ++   R+G       GL 
Sbjct: 926  SDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHG-------GLA 978

Query: 346  KAGGKSVPHPY---------ESRHVVVHPSPS-----DYSSRDPSGVRASVMVLPNSNTP 391
               G    HP+         E   + +   P+      Y+ R  +  + +  V    N P
Sbjct: 979  LQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGNDP 1038

Query: 392  AADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVG--LP 449
             A L++   T      S ++  S LHL    H+  A+  H    + H   +PL  G  L 
Sbjct: 1039 LARLQMLNVTPHHHQHSHIH--SHLHL----HQQDAI--HAASASVHPLIDPLASGSHLT 1090

Query: 450  ATAFYAGTQP 459
               + AGT P
Sbjct: 1091 RIPYPAGTLP 1100


>gi|55750041 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 128/525 (24%), Positives = 180/525 (34%), Gaps = 96/525 (18%)

Query: 13  PPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGTSVELGLQ 72
           PP K   P T+       P+ P   +    T  LP  P  R        P G   +  L 
Sbjct: 271 PPTK---PPTTPVGGGNLPSAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGAQ-PLP 326

Query: 73  QGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGS 132
             +    A+  G+   PP  P   P     P +        P  P+++ +   +     +
Sbjct: 327 GHLPSPHAMGQGMGGLPPG-PEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSSAAA 385

Query: 133 SQYSGTYAS----FIPSQLIP--------PTANPVTSAVASAAGATTPSQRSQLEA---- 176
           S  S + +S    F  SQ +P        PT+  V++        + PSQ    +     
Sbjct: 386 SSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPP 445

Query: 177 --YSTLLANMGSL---------SQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQ 225
             Y  LLAN  +          +Q+  H          QQQQQ Q  QQQQQQQQQQQQ 
Sbjct: 446 PPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQ--QQQQQQQQQQQQH 503

Query: 226 HLSRAPGLITPGS-PPPAQ--QNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLT 282
           H +  P    PG+ P P +   + + H  +   + G     P  P HL P          
Sbjct: 504 HGNSGPP--PPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPP---------- 551

Query: 283 LGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAP----- 337
             P SQV   Y+ +G +  P  ++  + SS  Q +         +  +   Y  P     
Sbjct: 552 --PHSQV--SYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTV 607

Query: 338 --SSADLGL-------GKAGGKSV----PHPYESRHVVVHPSPSDYSSRDPSGVRASVMV 384
             SSA L           AG K+     P PY  R     PSP  Y +  P G +     
Sbjct: 608 TTSSATLSTVIATVASSPAGYKTASPPGPPPYGKR----APSPGAYKTATPPGYKPGSPP 663

Query: 385 LPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPL 444
              + TP       + T   A P T          KPG  +    P      +   S P 
Sbjct: 664 SFRTGTPPG----YRGTSPPAGPGTF---------KPGSPTVGPGPLPPAGPSGLPSLPP 710

Query: 445 PVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQP 489
           P   PA+       PP+      Q+ A  Y    P+  V P   P
Sbjct: 711 PPAAPASG------PPLSATQIKQEPAEEY--ETPESPVPPARSP 747



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 125/579 (21%), Positives = 170/579 (29%), Gaps = 115/579 (19%)

Query: 50  PGGRGH--GGGRHGPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYA 107
           PGG G    G   GP G     G    +G     + G  + PP+ P SV  +     A  
Sbjct: 221 PGGTGGVLSGPPMGPKGG----GAASSVG---GPNGGKQHPPPTTPISVSSS----GASG 269

Query: 108 TPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAG--- 164
            P    P +PV   +LP       S+     +    P+   PP   P+ +A AS  G   
Sbjct: 270 APPTKPPTTPVGGGNLP-------SAPPPANFPHVTPNLPPPPALRPLNNASASPPGLGA 322

Query: 165 -------------------------------------------ATTPSQRSQLEAYSTLL 181
                                                      A  P  R    + S+  
Sbjct: 323 QPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPPMRFPYSSSSSSS 382

Query: 182 ANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQ-----QQQQQQQQQQQQQHLSRAPGLITP 236
           A   S S +    A      Q      H            Q  +  Q    S+A     P
Sbjct: 383 AAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGP 442

Query: 237 GSPPPAQQ---NQYVHISSSPQNTG--RTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVM 291
             PPP  +   N   H    P +TG   TA PP +  H H HQ             Q   
Sbjct: 443 PPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPP-VSTHHHHHQQQQQQQQQQQQQQQQQQ 501

Query: 292 QYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYG------APSSADLGLG 345
           Q+  +     P       E      A      ++  +   R Y        P  + +   
Sbjct: 502 QHHGNSGPPPPGAFPHPLEGGSSHHA--HPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYS 559

Query: 346 KAGGKSVPHPYESR---------HVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLE 396
           +AG    P    S          +   HPSP    S+ P G       +P   T +A L 
Sbjct: 560 QAGPNGPPVSSSSNSSSSTSQGSYPCSHPSP----SQGPQGAPYPFPPVPTVTTSSATLS 615

Query: 397 VQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAG 456
              AT    + S    K+    G P +   A SP      T    +P   G P  +F  G
Sbjct: 616 TVIAT---VASSPAGYKTASPPGPPPYGKRAPSPGAYKTATPPGYKP---GSP-PSFRTG 668

Query: 457 TQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFA 516
           T P   GY      A           V PG  P   P G + + +    PA   S P  +
Sbjct: 669 TPP---GYRGTSPPAGPGTFKPGSPTVGPGPLP---PAGPSGLPSLPPPPAAPASGPPLS 722

Query: 517 AVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLP 555
           A          P  E   PE+ V  A  P+     + +P
Sbjct: 723 ATQ----IKQEPAEEYETPESPVPPARSPSPPPKVVDVP 757



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 92/430 (21%), Positives = 161/430 (37%), Gaps = 86/430 (20%)

Query: 89   PPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIP--SQ 146
            PP+ P  +P   +LP   A P  G P+S  Q    P       + +Y    +   P  S 
Sbjct: 698  PPAGPSGLP---SLPPPPAAPASGPPLSATQIKQEP-------AEEYETPESPVPPARSP 747

Query: 147  LIPPTANPVTSAVASAAGATTPSQR-----SQLEAY------STLLANMGSLSQTPGHKA 195
              PP    V S  + +A       R     ++ + Y      S L      L +    +A
Sbjct: 748  SPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKRADLVEKVRREA 807

Query: 196  EQQ-----QQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSP----PPAQQNQ 246
            EQ+     ++++++++++ + ++++++ ++  +     RAP       P    PP +   
Sbjct: 808  EQRAREEKEREREREREKEREREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGS 867

Query: 247  YVHISSSPQNTG------RTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQY------- 293
             V  ++ P   G      RT S  A P  + P     P  + LG     ++ Y       
Sbjct: 868  AV--ATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLGAVDPGLLGYNVPALYS 925

Query: 294  ADSGSHFVPREATKKAESSRLQQAIQAK----EVLNG----EMEKSRRYGAPSSADLGLG 345
            +D  +    REA ++    RL+   + K    E L+G     ++   R+G       GL 
Sbjct: 926  SDPAAREREREARERDLRDRLKPGFEVKPSELEPLHGVPGPGLDPFPRHG-------GLA 978

Query: 346  KAGGKSVPHPY---------ESRHVVVHPSPS-----DYSSRDPSGVRASVMVLPNSNTP 391
               G    HP+         E   + +   P+      Y+ R  +  + +  V    N P
Sbjct: 979  LQPGPPGLHPFPFHPSLGPLERERLALAAGPALRPDMSYAERLAAERQHAERVAALGNDP 1038

Query: 392  AADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVG--LP 449
             A L++   T      S ++  S LHL    H+  A+  H    + H   +PL  G  L 
Sbjct: 1039 LARLQMLNVTPHHHQHSHIH--SHLHL----HQQDAI--HAASASVHPLIDPLASGSHLT 1090

Query: 450  ATAFYAGTQP 459
               + AGT P
Sbjct: 1091 RIPYPAGTLP 1100


>gi|4507379 TATA box binding protein [Homo sapiens]
          Length = 339

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 62/174 (35%), Positives = 76/174 (43%), Gaps = 24/174 (13%)

Query: 154 PVTSAVASAAGATTPSQR--SQLEAYSTLLA-----NMGSLSQTPGHKAEQQQQQQQQQQ 206
           P    +AS  GA TP     S +  Y T L      N  SLS     + +QQQQQQQQQQ
Sbjct: 9   PYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQQQQQQQQQ 68

Query: 207 QQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAI 266
           QQ Q QQQQQQQQQQQQQQ   +             QQ Q V  ++  Q+T + A+    
Sbjct: 69  QQQQQQQQQQQQQQQQQQQQQQQ-------------QQQQAVAAAAVQQSTSQQATQGTS 115

Query: 267 PVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVP-REATKKAESSRLQQAIQ 319
                  Q     TLT  P       Y    +   P   AT  +ESS +   +Q
Sbjct: 116 G---QAPQLFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQ 166


>gi|110347429 mediator complex subunit 12 [Homo sapiens]
          Length = 2177

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 44/110 (40%), Positives = 52/110 (47%), Gaps = 7/110 (6%)

Query: 145  SQLIPPTANPVTSAVASAA--GATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQ- 201
            S + P +A  V + V S A        Q+ Q +             Q   H  +QQQQQ 
Sbjct: 2028 STMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQI 2087

Query: 202  ----QQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQY 247
                QQQQQQQ Q QQQQQQQQQQQQQQH  +      P  P P  Q Q+
Sbjct: 2088 LRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQF 2137



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 32/51 (62%), Positives = 35/51 (68%)

Query: 194  KAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQ 244
            + +QQQQQQQQQQQQ Q QQQQQQQQQ QQQQ    AP    P S P  Q+
Sbjct: 2089 RQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQR 2139



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 27/58 (46%), Positives = 29/58 (50%)

Query: 189  QTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQ 246
            Q    + +QQQQQQQQQQQQ Q  QQQQQQQ    Q      P     G     QQ Q
Sbjct: 2093 QQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQ 2150



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 28/60 (46%), Positives = 31/60 (51%), Gaps = 18/60 (30%)

Query: 189  QTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQ------------------QQQQQQHLSRA 230
            Q    + +QQQQQQQQQQQQ QHQQQQQQQ                   QQ QQQ  + A
Sbjct: 2094 QQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAA 2153


>gi|56549696 E1A binding protein p400 [Homo sapiens]
          Length = 3122

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 122/513 (23%), Positives = 175/513 (34%), Gaps = 77/513 (15%)

Query: 97   PVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVT 156
            PVA   P A  TP      +P Q  H     + +GS     T    + S         VT
Sbjct: 2620 PVA---PGALTTPGGS---APAQVVHTQPPPRAVGSP---ATATPDLVSMATTQGVRAVT 2670

Query: 157  SAVASAAGAT------TPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQ 210
            S  ASA   T      TP++    +        +   + TP H    +QQQQQQQQQQ Q
Sbjct: 2671 SVTASAVVTTNLTPVQTPARSLVPQVSQATGVQLPGKTITPAHFQLLRQQQQQQQQQQQQ 2730

Query: 211  HQQQQQQQQQQQQQQHLS---------------------RAPGLITPGSPPPAQQNQYVH 249
             QQQQQQQQQQQQQQ  +                     +A G +TP      Q+ +   
Sbjct: 2731 QQQQQQQQQQQQQQQQQTTTTSQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKMQKQKLQM 2790

Query: 250  ISSSPQNTGRTASP-PAIPVHL---HPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREA 305
                P    ++A P P   V +    P Q   P   T+  P    +    + ++      
Sbjct: 2791 PPQPPPPQAQSAPPQPTAQVQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVANLQVARL 2850

Query: 306  TKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHP 365
            T +  +S+LQ          G+M+      AP  A + L K    SVP       VV  P
Sbjct: 2851 T-RVPTSQLQ--------AQGQMQTQ----APQPAQVALAKPPVVSVP-----AAVVSSP 2892

Query: 366  SPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRS 425
              +      P  V    + +      A    V Q  H +     L  K      +   + 
Sbjct: 2893 GVTTL----PMNVAGISVAIGQPQKAAGQTVVAQPVHMQ---QLLKLKQQAVQQQKAIQP 2945

Query: 426  YALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLS---GQQQAITYAGSLPQHL 482
             A      +Q   +A +    G      YA        +L+    Q Q +  A  +   +
Sbjct: 2946 QAAQGPAAVQQKITAQQITTPGAQQKVAYAAQPALKTQFLTTPISQAQKLAGAQQVQTQI 3005

Query: 483  VI---PGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALV 539
             +   P       PV S    AS +  A    SPQ  A+  T  T A  + +        
Sbjct: 3006 QVAKLPQVVQQQTPVASIQQVASASQQA----SPQTVAL--TQATAAGQQVQMIPAVTAT 3059

Query: 540  TQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPP 572
             Q     ++Q Q+       + +P A  P   P
Sbjct: 3060 AQVVQQKLIQQQVVTTASAPLQTPGAPNPAQVP 3092



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 67/290 (23%), Positives = 101/290 (34%), Gaps = 35/290 (12%)

Query: 88   SPPSAPRSVPVATTLPAAYATPQ-------------PGTPVSPVQYAHLPH--TFQFIGS 132
            +PP     V V T+ P    +PQ              GT V+ +Q A L    T Q    
Sbjct: 2802 APPQPTAQVQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVANLQVARLTRVPTSQLQAQ 2861

Query: 133  SQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQ----------RSQLEAYSTLLA 182
             Q            L  P    V +AV S+ G TT             + Q  A  T++A
Sbjct: 2862 GQMQTQAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAGISVAIGQPQKAAGQTVVA 2921

Query: 183  NMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQ------QQHLSRA--PGLI 234
                + Q    K +  QQQ+  Q Q  Q     QQ+   QQ      QQ ++ A  P L 
Sbjct: 2922 QPVHMQQLLKLKQQAVQQQKAIQPQAAQGPAAVQQKITAQQITTPGAQQKVAYAAQPALK 2981

Query: 235  TPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTM--IPHTLTLGPPSQVVMQ 292
            T     P  Q Q +  +   Q   + A  P +     P  ++  +        P  V + 
Sbjct: 2982 TQFLTTPISQAQKLAGAQQVQTQIQVAKLPQVVQQQTPVASIQQVASASQQASPQTVALT 3041

Query: 293  YADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADL 342
             A +    V       A +  +QQ +  ++V+       +  GAP+ A +
Sbjct: 3042 QATAAGQQVQMIPAVTATAQVVQQKLIQQQVVTTASAPLQTPGAPNPAQV 3091



 Score = 30.8 bits (68), Expect = 5.3
 Identities = 61/246 (24%), Positives = 91/246 (36%), Gaps = 27/246 (10%)

Query: 185 GSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQ 244
           G +  TP      Q   Q+Q QQQ+        Q        L + PG + P   P A  
Sbjct: 514 GGMPPTP---QAAQLAGQRQSQQQYDPSTGPPVQNAASLHTPLPQLPGRLPPAGVPTAAL 570

Query: 245 NQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVV----MQYADSGSHF 300
           +  +  +  PQ      +   IPV     +T  P+     PPS  +     Q A    H 
Sbjct: 571 SSALQFAQQPQ-VVEAQTQLQIPV-----KTQQPNVPIPAPPSSQLPIPPSQPAQLALH- 623

Query: 301 VPREATKKAESSRLQQAIQ--AKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYES 358
           VP     + ++S+L    Q  A   L  +         P+S+   L    G S P P  +
Sbjct: 624 VPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPRPLPTSSTSSLAPVSG-SGPGPSPA 682

Query: 359 RHVVVH-PSP------SDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLN 411
           R   V+ PS       S  +SR P GV AS    P S  PA +    Q + ++     + 
Sbjct: 683 RSSPVNRPSSATNKALSPVTSRTP-GVVASAPTKPQS--PAQNATSSQDSSQDTLTEQIT 739

Query: 412 DKSGLH 417
            ++ +H
Sbjct: 740 LENQVH 745


>gi|93141033 PAX interacting protein 1 [Homo sapiens]
          Length = 1069

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 56/171 (32%), Positives = 65/171 (38%), Gaps = 20/171 (11%)

Query: 109 PQPGTPVSPV-------QYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTA--NPVTSAV 159
           P P  P  P        Q AH PH        Q+S     F   QL PP     P     
Sbjct: 439 PYPQQPPHPFSQQQQQQQQAH-PH--------QFSQQQLQFPQQQLHPPQQLHRPQQQLQ 489

Query: 160 ASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQ 219
                     Q  QL+ +      +  L Q      +QQQQQ QQQQ Q  HQQQQQQQ 
Sbjct: 490 PFQQQHALQQQFHQLQQHQLQQQQLAQLQQQHSLLQQQQQQQIQQQQLQRMHQQQQQQQM 549

Query: 220 QQQQQQHLSRAPGLITPGSPP--PAQQNQYVHISSSPQNTGRTASPPAIPV 268
           Q Q   HLS+    +    PP  P QQ Q      SPQ        PA+ +
Sbjct: 550 QSQTAPHLSQTSQALQHQVPPQQPPQQQQQQQPPPSPQQHQLFGHDPAVEI 600



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 49/191 (25%), Positives = 75/191 (39%), Gaps = 29/191 (15%)

Query: 85  LDYSPPSAPRSVPVATTLP----------AAYATPQPGTPVSPVQYAHLPHTFQFIGSSQ 134
           L+++P   P+       LP           A   P PG  + P    +L    Q + SS+
Sbjct: 264 LNWTPAEVPQLAAAKRRLPQGKEPGLINLCANVPPVPGNILPPEVRGNLMAAGQNLQSSE 323

Query: 135 YSGTYASFIPS--------------QLIPPT-----ANPVTSAVASAAGATTPSQRSQLE 175
            S   A++ P+              Q+  P+        +++   +       SQ+    
Sbjct: 324 RSEMIATWSPAVRTLRNITNNADIQQMNRPSNVAHILQTLSAPTKNLEQQVNHSQQGHTN 383

Query: 176 AYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLIT 235
           A + L + +    +T   + +QQ QQQQQQ      Q QQ  Q QQQQQQ +S+ P    
Sbjct: 384 ANAVLFSQVKVTPETHMLQQQQQAQQQQQQHPVLHLQPQQIMQLQQQQQQQISQQPYPQQ 443

Query: 236 PGSPPPAQQNQ 246
           P  P   QQ Q
Sbjct: 444 PPHPFSQQQQQ 454



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 32/84 (38%), Positives = 36/84 (42%), Gaps = 7/84 (8%)

Query: 168 PSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQH- 226
           P Q  QL+       +     Q P H   QQ   QQQQQQ H HQ  QQQ Q  QQQ H 
Sbjct: 421 PQQIMQLQQQQQQQISQQPYPQQPPHPFSQQ---QQQQQQAHPHQFSQQQLQFPQQQLHP 477

Query: 227 ---LSRAPGLITPGSPPPAQQNQY 247
              L R    + P     A Q Q+
Sbjct: 478 PQQLHRPQQQLQPFQQQHALQQQF 501


>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
          Length = 1424

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 48/127 (37%), Positives = 60/127 (47%), Gaps = 24/127 (18%)

Query: 150  PTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQH 209
            P   P  S+      A   +QRS+      LL++     +      +QQQQQQQQQQQQ 
Sbjct: 1208 PMMQPQVSSQQGFLNAQMVAQRSR-----ELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQ 1262

Query: 210  QHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASP--PAIP 267
            Q QQQQQQQQQQQQ Q            SPPP       ++++SP   G  A P  P  P
Sbjct: 1263 QQQQQQQQQQQQQQTQAF----------SPPP-------NVTASPSMDGLLAGPTMPQAP 1305

Query: 268  VHLHPHQ 274
                P+Q
Sbjct: 1306 PQQFPYQ 1312


>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
          Length = 1420

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 40/82 (48%), Positives = 47/82 (57%), Gaps = 15/82 (18%)

Query: 195  AEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSP 254
            A   QQQQQQQQQQ Q QQQQQQQQQQQQQQ  ++A       SPPP       ++++SP
Sbjct: 1240 AMMMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQA------FSPPP-------NVTASP 1286

Query: 255  QNTGRTASP--PAIPVHLHPHQ 274
               G  A P  P  P    P+Q
Sbjct: 1287 SMDGLLAGPTMPQAPPQQFPYQ 1308


>gi|17017963 forkhead box P2 isoform I [Homo sapiens]
          Length = 715

 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 64/230 (27%), Positives = 82/230 (35%), Gaps = 35/230 (15%)

Query: 27  EEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGTSVE----LGLQQGIGLHKALS 82
           E    T+ + +    G + L          G   G   + V     L LQQ   L  A  
Sbjct: 4   ESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQ 63

Query: 83  TGLDY------SPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYS 136
             L        SP S+ +  P+   +  A  TPQ  TP    Q                 
Sbjct: 64  LLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQ----------------- 106

Query: 137 GTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAE 196
                 +  Q++ P       A+     A    Q+   E Y      +         + +
Sbjct: 107 -----ILQQQVLSPQQ---LQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQ 158

Query: 197 QQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQ 246
           QQQQQQQQQQQQ Q QQQQQQQQQQQQQQ   + PG          QQ Q
Sbjct: 159 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQ 208



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 40/93 (43%), Positives = 50/93 (53%), Gaps = 4/93 (4%)

Query: 189 QTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYV 248
           Q    + +QQQQQQQQQQQQH  +Q ++QQQQQQQQQ L+ A  L+        QQ Q  
Sbjct: 172 QQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLA-AQQLVFQQQLLQMQQLQQQ 230

Query: 249 HISSSPQNTGRTASPP---AIPVHLHPHQTMIP 278
               S Q  G  + PP   A+PV   P   + P
Sbjct: 231 QHLLSLQRQGLISIPPGQAALPVQSLPQAGLSP 263


>gi|22538413 forkhead box P2 isoform III [Homo sapiens]
          Length = 623

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 34/58 (58%), Positives = 36/58 (62%), Gaps = 9/58 (15%)

Query: 189 QTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQ 246
           Q    + +QQQQQQQQQQQQ Q QQQQQQQQQQQQQQH         PG     QQ Q
Sbjct: 63  QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQH---------PGKQAKEQQQQ 111



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 32/51 (62%), Positives = 34/51 (66%)

Query: 196 EQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQ 246
           +QQQQQQQQQQQQ Q QQQQQQQQQQQQQQ   + PG          QQ Q
Sbjct: 66  QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQ 116



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 40/93 (43%), Positives = 50/93 (53%), Gaps = 4/93 (4%)

Query: 189 QTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYV 248
           Q    + +QQQQQQQQQQQQH  +Q ++QQQQQQQQQ L+ A  L+        QQ Q  
Sbjct: 80  QQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLA-AQQLVFQQQLLQMQQLQQQ 138

Query: 249 HISSSPQNTGRTASPP---AIPVHLHPHQTMIP 278
               S Q  G  + PP   A+PV   P   + P
Sbjct: 139 QHLLSLQRQGLISIPPGQAALPVQSLPQAGLSP 171



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 27/60 (45%), Positives = 35/60 (58%), Gaps = 1/60 (1%)

Query: 167 TPSQ-RSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQ 225
           +P Q ++ L+    ++     L +    + EQ   Q  QQQQQ Q QQQQQQQQQQQQQQ
Sbjct: 22  SPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQ 81


>gi|149999352 forkhead box P2 isoform II [Homo sapiens]
          Length = 740

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 34/58 (58%), Positives = 36/58 (62%), Gaps = 9/58 (15%)

Query: 189 QTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQ 246
           Q    + +QQQQQQQQQQQQ Q QQQQQQQQQQQQQQH         PG     QQ Q
Sbjct: 180 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQH---------PGKQAKEQQQQ 228



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 32/51 (62%), Positives = 34/51 (66%)

Query: 196 EQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQ 246
           +QQQQQQQQQQQQ Q QQQQQQQQQQQQQQ   + PG          QQ Q
Sbjct: 183 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQ 233



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 40/93 (43%), Positives = 50/93 (53%), Gaps = 4/93 (4%)

Query: 189 QTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYV 248
           Q    + +QQQQQQQQQQQQH  +Q ++QQQQQQQQQ L+ A  L+        QQ Q  
Sbjct: 197 QQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLA-AQQLVFQQQLLQMQQLQQQ 255

Query: 249 HISSSPQNTGRTASPP---AIPVHLHPHQTMIP 278
               S Q  G  + PP   A+PV   P   + P
Sbjct: 256 QHLLSLQRQGLISIPPGQAALPVQSLPQAGLSP 288



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 27/60 (45%), Positives = 35/60 (58%), Gaps = 1/60 (1%)

Query: 167 TPSQ-RSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQ 225
           +P Q ++ L+    ++     L +    + EQ   Q  QQQQQ Q QQQQQQQQQQQQQQ
Sbjct: 139 SPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQ 198



 Score = 34.7 bits (78), Expect = 0.37
 Identities = 26/76 (34%), Positives = 35/76 (46%), Gaps = 6/76 (7%)

Query: 156 TSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQ 215
           T AV  +    TP   +  +    L   + S  Q      +QQ    QQQQ Q  +++QQ
Sbjct: 109 TFAVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQ 168

Query: 216 QQ------QQQQQQQQ 225
           +Q      QQQQQQQQ
Sbjct: 169 EQLHLQLLQQQQQQQQ 184


>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
          Length = 748

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 76/263 (28%), Positives = 101/263 (38%), Gaps = 30/263 (11%)

Query: 193 HKAEQQQQQQQQQQQQH--QHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHI 250
           H   QQQ QQQQQQ Q   Q Q QQQQQQQQQQQQ   +A     P   PP QQ Q    
Sbjct: 224 HHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPS 283

Query: 251 SSSPQ------NTGRTASPP---AIPVHLHPHQTMIPHTLTLGPPSQV-----VMQYADS 296
            + PQ      +T     PP     PV  +    + P + T    SQ       M Y   
Sbjct: 284 QALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQP 343

Query: 297 GSHFV---------PREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKA 347
              FV         P +   + + + +Q A  A+ V  G           SS   G    
Sbjct: 344 PLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQ 403

Query: 348 GGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASP 407
             +S+P P +       P P   SS+  S V +     P+S  P+   +  Q+     +P
Sbjct: 404 TPQSMPPPPQP-----SPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTP 458

Query: 408 STLNDKSGLHLGKPGHRSYALSP 430
              +  S   L  P + S  +SP
Sbjct: 459 QNFSVPSPGPLNTPVNPSSVMSP 481



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 104/475 (21%), Positives = 174/475 (36%), Gaps = 82/475 (17%)

Query: 154 PVTSAVA--SAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQH 211
           P TS +A  S A  +T + ++QL+     L               QQQQQQQQ QQQ Q 
Sbjct: 131 PGTSGMAPHSMAVVSTATPQTQLQLQQVAL---------------QQQQQQQQFQQQQQA 175

Query: 212 QQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLH 271
             QQQQQQQQQQQ    ++           A Q Q+  +    Q              L 
Sbjct: 176 ALQQQQQQQQQQQFQAQQS-----------AMQQQFQAVVQQQQ-------------QLQ 211

Query: 272 PHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGE---M 328
             Q    H + L   +Q  +Q        + +   ++ +  + QQ  Q ++ L  +    
Sbjct: 212 QQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQ 271

Query: 329 EKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNS 388
           +   +   P  +         +++P   +  H   H  P     + P        + P S
Sbjct: 272 QPPMQQPQPPPS---------QALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQS 322

Query: 389 NTPAADLEVQQATHR--EASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPV 446
            T     + Q    +     P     ++ + + +P  +       T +QT  +A    P 
Sbjct: 323 QTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAP- 381

Query: 447 GLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAP 506
           G+  +     +  P++   S  QQ  T     PQ +  P  QP   P      + S    
Sbjct: 382 GVQVSQ----SSLPMLSSPSPGQQVQT-----PQSMP-PPPQPSPQP-----GQPSSQPN 426

Query: 507 AIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPV-VQSVASPAA 565
           + V+S P  A  P +F+ +  P+    +P    T   +       ++ PV   SV SPA 
Sbjct: 427 SNVSSGP--APSPSSFLPSPSPQPSQ-SPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAG 483

Query: 566 APPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIED 620
           +       ++   + QL+    K +E L+    I   + + D K D S ++ + D
Sbjct: 484 SSQAEEQQYL-DKLKQLS----KYIEPLRR--MINKIDKNEDRKKDLSKMKSLLD 531



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 42/185 (22%), Positives = 78/185 (42%), Gaps = 29/185 (15%)

Query: 93  PRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTA 152
           P+S+P     P    +PQPG P S       P++     SS  + + +SF+PS    P+ 
Sbjct: 405 PQSMP-----PPPQPSPQPGQPSSQ------PNSNV---SSGPAPSPSSFLPSPSPQPSQ 450

Query: 153 NPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQ 212
           +PVT+         +P   +     S++++  GS       +AE+QQ   + +Q     +
Sbjct: 451 SPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGS------SQAEEQQYLDKLKQLSKYIE 504

Query: 213 QQQQQ----QQQQQQQQHLSRAPGLI----TPGSPPPAQQNQYVHIS-SSPQNTGRTASP 263
             ++      + + +++ LS+   L+     P    P +  Q   I+    +N     +P
Sbjct: 505 PLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTP 564

Query: 264 PAIPV 268
           P  PV
Sbjct: 565 PPPPV 569


>gi|33286444 mastermind-like 2 [Homo sapiens]
          Length = 1156

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 39/103 (37%), Positives = 48/103 (46%), Gaps = 6/103 (5%)

Query: 187 LSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLS------RAPGLITPGSPP 240
           L  T   + +QQQQQQQQQQQQ Q QQQQQQQQQQQQQ  +S      +   +       
Sbjct: 584 LHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQ 643

Query: 241 PAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTL 283
             QQ Q        Q   +   P + P    P Q ++   L L
Sbjct: 644 QQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPL 686



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 35/75 (46%), Positives = 41/75 (54%)

Query: 170 QRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSR 229
           Q+ Q +  S++ A      Q+     +QQQQQQQQQQQQ Q QQQQQQQQQQ   Q    
Sbjct: 614 QQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQS 673

Query: 230 APGLITPGSPPPAQQ 244
            P      SP P QQ
Sbjct: 674 LPSQPLLRSPLPLQQ 688



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 36/64 (56%), Positives = 38/64 (59%)

Query: 183 NMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPA 242
           N  SL      + +QQQQQQQQQQQQ Q QQQQQQQQQQQQQQ    A       S   A
Sbjct: 579 NKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISA 638

Query: 243 QQNQ 246
           QQ Q
Sbjct: 639 QQQQ 642



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 46/152 (30%), Positives = 57/152 (37%), Gaps = 8/152 (5%)

Query: 107 ATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFI---PSQLIPPTANPVTSAVASAA 163
           ++P PG      Q   + +     G S   G     +   P  L     N    A+    
Sbjct: 494 SSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQ 553

Query: 164 GATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQ 223
           G T P     L  +++  AN    S  P           QQQQQQ Q QQQQQQQQQQQQ
Sbjct: 554 GNTKP-----LFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQ 608

Query: 224 QQHLSRAPGLITPGSPPPAQQNQYVHISSSPQ 255
           QQ   +        S    QQ Q     S+ Q
Sbjct: 609 QQQQQQQQQQQQQSSISAQQQQQQQSSISAQQ 640



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 48/188 (25%), Positives = 71/188 (37%), Gaps = 22/188 (11%)

Query: 107 ATPQPGTPVSPVQYAHLPHTFQFIGSSQYSG--TYASFIPSQLIPPTANPVTSAVASAAG 164
           +TP+P  P+  +           +  S+YS   T       QL PP+A P  S   SA  
Sbjct: 351 STPRPSLPMEKI-----------VIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALS 399

Query: 165 ATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQ---QQQQHQHQQQQQQQQQQ 221
            ++P   S  ++ +      G+    P  +     QQ +Q    +QQH   QQ QQQ Q 
Sbjct: 400 TSSPIP-SVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQP 458

Query: 222 QQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASP-PAIPVHLHPHQTMIPHT 280
                L  + G     SP P  Q +    S   Q     +SP P +       + M  + 
Sbjct: 459 TNWSALPSSAG----PSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYM 514

Query: 281 LTLGPPSQ 288
              GP +Q
Sbjct: 515 YKAGPSAQ 522


>gi|55956910 meningioma  1 [Homo sapiens]
          Length = 1320

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 37/75 (49%), Positives = 39/75 (52%), Gaps = 16/75 (21%)

Query: 191 PGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQ----------------QQHLSRAPGLI 234
           P H++ QQQQQQQQQQQQ Q QQQQQQQQQQQQ                QQ   R P L 
Sbjct: 517 PDHQSLQQQQQQQQQQQQQQQQQQQQQQQQQQQQRQNAALMIKQMASRNQQQRLRQPNLA 576

Query: 235 TPGSPPPAQQNQYVH 249
             G P    Q   VH
Sbjct: 577 QLGHPGDVGQGGLVH 591



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 25/33 (75%), Positives = 25/33 (75%)

Query: 193 HKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQ 225
           H A   Q  QQQQQQQ Q QQQQQQQQQQQQQQ
Sbjct: 514 HPAPDHQSLQQQQQQQQQQQQQQQQQQQQQQQQ 546



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 105/439 (23%), Positives = 146/439 (33%), Gaps = 120/439 (27%)

Query: 34  PSDNHRVEGTAWLPGNPGGRG------HGGGRHGPAGTSVELGLQQGIGL---HKALSTG 84
           P  +H  +      GN GG        HGG   G  G +  LG Q        H A S G
Sbjct: 102 PGSHHPHQHHPHFGGNFGGPDPGASCLHGGRLLGYGGAAGGLGSQPPFAEGYEHMAESQG 161

Query: 85  LDYSPPSAPRSVP-VATTLPAAYATPQPGTPV--SPVQYAH---LP-------HTFQ--- 128
            +   P  P ++P   ++  +++A P P  P+  SP + A    LP       H+ +   
Sbjct: 162 PESFGPQRPGNLPDFHSSGASSHAVPAPCLPLDQSPNRAASFHGLPSSSGSDSHSLEPRR 221

Query: 129 -----FIGSSQY-------SGTYASFIPS------------QLIPPTANPVTSAVASAAG 164
                 + S +Y       SG +  F PS            + +P  A P  SA+  AAG
Sbjct: 222 VTNQGAVDSLEYNYPGEAPSGHFDMFSPSDSEGQLPHYAAGRQVPGGAFPGASAMPRAAG 281

Query: 165 ATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQH--------------- 209
                           +  +  +   P  +  QQQQQ QQQQQQH               
Sbjct: 282 ----------------MVGLSKMHAQPPQQQPQQQQQPQQQQQQHGVFFERFSGARKMPV 325

Query: 210 -------------QHQQQ-----QQQQQQQQQQQHLSRAPG-LITPGSPPPAQQNQYVHI 250
                        Q  QQ     QQQ  QQ  QQ     PG L+   S PPA        
Sbjct: 326 GLEPSVGSRHPLMQPPQQAPPPPQQQPPQQPPQQQPPPPPGLLVRQNSCPPALPRPQQGE 385

Query: 251 SSSPQNTGRTASPP--------AIPVHLHPHQTMIPH-----TLTLGPPSQVVMQYADSG 297
           + +P    +   P           P+H   +++M P+     ++   PP Q   Q     
Sbjct: 386 AGTPSGGLQDGGPMLPSQHAQFEYPIHRLENRSMHPYSEPVFSMQHPPPQQAPNQRL--- 442

Query: 298 SHFVPREATKKAESSRL----QQAIQAKEVLNGEMEKSRRYGAPS-SADLGLGKAGGKSV 352
            HF        A+  R        +      NG M         S SA  GL       V
Sbjct: 443 QHFDAPPYMNVAKRPRFDFPGSAGVDRCASWNGSMHNGALDNHLSPSAYPGLPGEFTPPV 502

Query: 353 PHPYESRHVVVHPSPSDYS 371
           P  + S   + HP+P   S
Sbjct: 503 PDSFPSGPPLQHPAPDHQS 521


>gi|38158015 mastermind-like 3 [Homo sapiens]
          Length = 1133

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 60/196 (30%), Positives = 81/196 (41%), Gaps = 46/196 (23%)

Query: 88  SPPSAPRS-------VPVATTLPAAYATPQPGTPVSP-----VQYAHLPHTFQFIGSSQY 135
           SP + P S       V  AT+LP+  +TP    P S      VQ    P+          
Sbjct: 373 SPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQTPNQ--------- 423

Query: 136 SGTYASFIPSQLIPPTANPVT---SAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPG 192
                +  P Q  P   N      +AV  A  A+ P     +   S+ ++    L Q   
Sbjct: 424 -----AHTPGQAPPRPGNGYLLNPAAVTVAGSASGP-----VAVPSSDMSPAEQLKQMAA 473

Query: 193 HKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISS 252
            + ++ +  QQ+QQQQ Q QQQQQQQQQQQQQQH ++     +P  PP           S
Sbjct: 474 QQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQHSNQTSNW-SPLGPP-----------S 521

Query: 253 SPQNTGRTASPPAIPV 268
           SP     TA  P  P+
Sbjct: 522 SPYGAAFTAEKPNSPM 537



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 99/399 (24%), Positives = 145/399 (36%), Gaps = 56/399 (14%)

Query: 110  QPGTPVSPVQYAHLPHTFQF---IGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGAT 166
            Q G    P+ YA LP   Q    +G  + +G   S +P     P +  + S  + A    
Sbjct: 671  QKGVMNQPMAYAALPSHGQEQHPVGLPRTTGPMQSSVP-----PGSGGMVSGASPAGPGF 725

Query: 167  TPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQH 226
              SQ         L+     L        EQQ+QQ  ++Q+Q Q QQQQ   +QQ QQ H
Sbjct: 726  LGSQPQAAIMKQMLIDQRAQL-------IEQQKQQFLREQRQQQQQQQQILAEQQLQQSH 778

Query: 227  LSRAPGLITPGSPPPAQQ-NQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHT--LTL 283
            L R   L    +P P QQ NQ+     SPQ+     S  A+   +   + M  +   + +
Sbjct: 779  LPR-QHLQPQRNPYPVQQVNQF---QGSPQDIAAVRSQAALQ-SMRTSRLMAQNAGMMGI 833

Query: 284  GP---PSQVVMQYADSGSHFVPREATKKAE------SSRLQQAIQAKEVLNGEMEKSRRY 334
            GP   P  +    A S     P   T  ++      S+ + Q +Q        +  ++  
Sbjct: 834  GPSQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQ 893

Query: 335  GAPSSAD-LGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAA 393
            G    A   G+G   G        S     HP       + P G       LP    P  
Sbjct: 894  GPRQPASGQGVGMVSGFGQSMLVNSAITQQHP-----QMKGPVG-----QALPRPQAPPR 943

Query: 394  DLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATA- 452
             L+    T ++ + S    +  L  G PG  S  L P       + AS PL  G P    
Sbjct: 944  -LQSLMGTVQQGAQSW--QQRSLQ-GMPGRTSGELGPF-----NNGASYPLQAGQPRLTK 994

Query: 453  --FYAGTQPPVIGYLSGQQQAITYAGSLPQHL-VIPGTQ 488
              F  G    V+   +G  + +  A    Q +  +PG Q
Sbjct: 995  QHFPQGLSQSVVDANTGTVRTLNPAAMGRQMMPSLPGQQ 1033



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 34/115 (29%), Positives = 50/115 (43%), Gaps = 2/115 (1%)

Query: 164 GATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQ 223
           G T P      +    +   + + ++ P     QQQQQQQQQQQQ Q QQQ    Q Q  
Sbjct: 596 GNTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAP 655

Query: 224 QQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIP 278
           + HLS     +          NQ +  ++ P + G+   P  +P    P Q+ +P
Sbjct: 656 RAHLSEDQKRLLL-MKQKGVMNQPMAYAALPSH-GQEQHPVGLPRTTGPMQSSVP 708


>gi|38787935 BMP-2 inducible kinase isoform a [Homo sapiens]
          Length = 1161

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 33/63 (52%), Positives = 36/63 (57%), Gaps = 5/63 (7%)

Query: 193 HKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISS 252
           H+   QQQQQQQQQQQ Q QQQQQQQQQQQQQ H      L+       A   QY H + 
Sbjct: 455 HRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLL-----QDAYMQQYQHATQ 509

Query: 253 SPQ 255
             Q
Sbjct: 510 QQQ 512



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 40/147 (27%), Positives = 54/147 (36%), Gaps = 20/147 (13%)

Query: 83  TGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASF 142
           T    +P   P++    T  P+        TPV  +                  G + + 
Sbjct: 364 TETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLA----------------PGEFGNH 407

Query: 143 IPSQLIPPTANPVTSAVASAAGATTPSQR---SQLEAYSTLLANMGSLSQTPGHKAEQQQ 199
            P   + P   P    +        P Q     QL+     L  +    + P  + +QQQ
Sbjct: 408 RPKGALRPGNGPEI-LLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQ 466

Query: 200 QQQQQQQQQHQHQQQQQQQQQQQQQQH 226
           QQQQQQQQQ Q QQQQQQQQ      H
Sbjct: 467 QQQQQQQQQQQQQQQQQQQQHHHHHHH 493



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 25/67 (37%), Positives = 31/67 (46%), Gaps = 8/67 (11%)

Query: 189 QTPGHKAEQQQQQQQQQQQQHQHQQQ--------QQQQQQQQQQQHLSRAPGLITPGSPP 240
           Q    + +QQQQQQQQQQQQH H            QQ Q   QQQ + +   L+     P
Sbjct: 467 QQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQP 526

Query: 241 PAQQNQY 247
               +QY
Sbjct: 527 QPSASQY 533



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 33/124 (26%), Positives = 46/124 (37%), Gaps = 20/124 (16%)

Query: 189 QTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYV 248
           Q    + +QQQQQQQQQQ  H H     Q    QQ QH ++   ++        QQ   +
Sbjct: 469 QQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQML--------QQQFLM 520

Query: 249 HISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKK 308
           H    PQ +               + TM+P         Q++ Q+  S     P   T  
Sbjct: 521 HSVYQPQPSA------------SQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSP 568

Query: 309 AESS 312
            E S
Sbjct: 569 QEFS 572


>gi|38787904 BMP-2 inducible kinase isoform b [Homo sapiens]
          Length = 662

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 33/63 (52%), Positives = 36/63 (57%), Gaps = 5/63 (7%)

Query: 193 HKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISS 252
           H+   QQQQQQQQQQQ Q QQQQQQQQQQQQQ H      L+       A   QY H + 
Sbjct: 455 HRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLL-----QDAYMQQYQHATQ 509

Query: 253 SPQ 255
             Q
Sbjct: 510 QQQ 512



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 40/147 (27%), Positives = 54/147 (36%), Gaps = 20/147 (13%)

Query: 83  TGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASF 142
           T    +P   P++    T  P+        TPV  +                  G + + 
Sbjct: 364 TETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLA----------------PGEFGNH 407

Query: 143 IPSQLIPPTANPVTSAVASAAGATTPSQR---SQLEAYSTLLANMGSLSQTPGHKAEQQQ 199
            P   + P   P    +        P Q     QL+     L  +    + P  + +QQQ
Sbjct: 408 RPKGALRPGNGPEI-LLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQ 466

Query: 200 QQQQQQQQQHQHQQQQQQQQQQQQQQH 226
           QQQQQQQQQ Q QQQQQQQQ      H
Sbjct: 467 QQQQQQQQQQQQQQQQQQQQHHHHHHH 493



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 25/67 (37%), Positives = 31/67 (46%), Gaps = 8/67 (11%)

Query: 189 QTPGHKAEQQQQQQQQQQQQHQHQQQ--------QQQQQQQQQQQHLSRAPGLITPGSPP 240
           Q    + +QQQQQQQQQQQQH H            QQ Q   QQQ + +   L+     P
Sbjct: 467 QQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQP 526

Query: 241 PAQQNQY 247
               +QY
Sbjct: 527 QPSASQY 533



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 33/124 (26%), Positives = 46/124 (37%), Gaps = 20/124 (16%)

Query: 189 QTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYV 248
           Q    + +QQQQQQQQQQ  H H     Q    QQ QH ++   ++        QQ   +
Sbjct: 469 QQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQML--------QQQFLM 520

Query: 249 HISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKK 308
           H    PQ +               + TM+P         Q++ Q+  S     P   T  
Sbjct: 521 HSVYQPQPSA------------SQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSP 568

Query: 309 AESS 312
            E S
Sbjct: 569 QEFS 572


>gi|239757877 PREDICTED: FERM and PDZ domain containing 3 [Homo
            sapiens]
          Length = 1662

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 34/57 (59%), Positives = 38/57 (66%), Gaps = 6/57 (10%)

Query: 189  QTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLIT---PGSPPPA 242
            ++      QQQQQQQQQQQQ   QQQQQQQQQQQQQQ ++ A G  T   PGSP  A
Sbjct: 1594 ESTARNLNQQQQQQQQQQQQ---QQQQQQQQQQQQQQQVAAAAGAATEHPPGSPTSA 1647


>gi|89060961 PREDICTED: FERM and PDZ domain containing 3 [Homo
            sapiens]
          Length = 1810

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 34/57 (59%), Positives = 38/57 (66%), Gaps = 6/57 (10%)

Query: 189  QTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLIT---PGSPPPA 242
            ++      QQQQQQQQQQQQ   QQQQQQQQQQQQQQ ++ A G  T   PGSP  A
Sbjct: 1742 ESTARNLNQQQQQQQQQQQQ---QQQQQQQQQQQQQQQVAAAAGAATEHPPGSPTSA 1795


>gi|89059963 PREDICTED: FERM and PDZ domain containing 3 [Homo
            sapiens]
          Length = 1810

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 34/57 (59%), Positives = 38/57 (66%), Gaps = 6/57 (10%)

Query: 189  QTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLIT---PGSPPPA 242
            ++      QQQQQQQQQQQQ   QQQQQQQQQQQQQQ ++ A G  T   PGSP  A
Sbjct: 1742 ESTARNLNQQQQQQQQQQQQ---QQQQQQQQQQQQQQQVAAAAGAATEHPPGSPTSA 1795


>gi|157743257 POU domain, class 6, transcription factor 2 [Homo
           sapiens]
          Length = 691

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 72/266 (27%), Positives = 102/266 (38%), Gaps = 47/266 (17%)

Query: 90  PSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIP 149
           P  P+ +  A  L +A A   PG P +  Q   +P    F  + Q  G         L  
Sbjct: 90  PVGPQPLLTAQQLASAVAGVMPGGPPALNQPILIP----FNMAGQLGGQQGLV----LTL 141

Query: 150 PTANPVTS---AVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQ 206
           PTAN         A+AAG         L+A S+L + +  L      + + QQQQQQQQQ
Sbjct: 142 PTANLTNIQGLVAAAAAGGIMTLPLQNLQATSSLNSQLQQL------QLQLQQQQQQQQQ 195

Query: 207 Q----QHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQ------------------ 244
           Q     +QH Q   Q   Q QQQ L   P    P  PPPA Q                  
Sbjct: 196 QPPPSTNQHPQPAPQAPSQSQQQPLQPTP----PQQPPPASQQPPAPTSQLQQAPQPQQH 251

Query: 245 --NQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVP 302
             + +    + P  T +++SPP  P     H   +P  LT   P Q+V     S +    
Sbjct: 252 QPHSHSQNQNQPSPTQQSSSPPQKPSQSPGHG--LPSPLTPPNPLQLVNNPLASQAAAAA 309

Query: 303 REATKKAESSRLQQAIQAKEVLNGEM 328
              +  A S     A+ + + + G++
Sbjct: 310 AAMSSIASSQAFGNALSSLQGVTGQL 335


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 38/81 (46%), Positives = 43/81 (53%), Gaps = 6/81 (7%)

Query: 170  QRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSR 229
            Q+ QL+    L      L Q    +  QQQQQQQ QQQQ Q QQQQQQQQQQ QQQ   +
Sbjct: 3916 QQQQLQQQQQL--QQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQ 3973

Query: 230  APGLITPG----SPPPAQQNQ 246
              GL+       SP   QQ Q
Sbjct: 3974 QMGLLNQSRTLLSPQQQQQQQ 3994



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 28/42 (66%), Positives = 29/42 (69%)

Query: 184  MGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQ 225
            MGSL Q    +  QQQQQ QQQQQQ   QQQQ QQQQ QQQQ
Sbjct: 3894 MGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQ 3935



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 38/117 (32%), Positives = 51/117 (43%), Gaps = 3/117 (2%)

Query: 183  NMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPA 242
            N+   S  P  +  Q++Q Q QQQ+    Q+ QQQQQQQQQQQHL     +       P 
Sbjct: 3703 NLALRSLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPG 3762

Query: 243  QQNQYVHISSSPQNTGRTASPPAIPV-HLHPHQTMIPHTLTLGPPSQVVMQYADSGS 298
             Q     +   PQ     +S   + V  L P     P  + LGP    V+Q    G+
Sbjct: 3763 VQTNQA-LGPKPQGLMPPSSHQGLLVQQLSPQPPQGPQGM-LGPAQVAVLQQQHPGA 3817



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 26/45 (57%), Positives = 28/45 (62%)

Query: 181  LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQ 225
            L     L Q    + +QQQQ QQQQQ Q Q  QQQQQQQQ QQQQ
Sbjct: 3900 LQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQ 3944



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 25/38 (65%), Positives = 27/38 (71%)

Query: 188  SQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQ 225
            +Q  G   + QQQQQ QQQQQ Q QQQQQ QQQQQ QQ
Sbjct: 3891 AQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQ 3928



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 27/49 (55%), Positives = 32/49 (65%), Gaps = 2/49 (4%)

Query: 179  TLLANMGS--LSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQ 225
            +L+++ G   LS  P    +Q QQQQQ QQQQ   QQQQQQ QQQQQ Q
Sbjct: 3879 SLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQ 3927



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 27/46 (58%), Positives = 29/46 (63%), Gaps = 1/46 (2%)

Query: 181  LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQ-QQQQQQQQQQQ 225
            L     L Q    + +QQQQ QQQQ QQ Q QQQ QQQQQQQ QQQ
Sbjct: 3906 LQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQ 3951



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 73/287 (25%), Positives = 95/287 (33%), Gaps = 71/287 (24%)

Query: 12   LPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRH----------- 60
            L P++R  PA   S    A  LP    +VE               GGRH           
Sbjct: 3094 LGPEERPPPAADASEPRLASVLPEVKPKVEE--------------GGRHPSPCQFTIATP 3139

Query: 61   ----GPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVS 116
                 PA  S+ LGL+ G  +  +  T +   P S+        +  A    P       
Sbjct: 3140 KVEPAPAANSLGLGLKPGQSMMGSRDTRMGTGPFSSSGHTAEKASFGATGGPP------- 3192

Query: 117  PVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEA 176
                AHL      +  S  SG   S +  +    +         +A+G       S L A
Sbjct: 3193 ----AHL------LTPSPLSGPGGSSLLEKFELESGALTLPGGPAASGDELDKMESSLVA 3242

Query: 177  YSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITP 236
                L     L     H+ ++ Q++QQ   Q    QQQQQQQQQ      L  APG    
Sbjct: 3243 SELPLLIEDLLE----HEKKELQKKQQLSAQLQPAQQQQQQQQQHS----LLSAPG---- 3290

Query: 237  GSPPPAQQNQYVHISSSPQNTGRT---------ASPPAIPVHLHPHQ 274
                PAQ     H  SSP   G           A  P +P  L P Q
Sbjct: 3291 ----PAQAMSLPHEGSSPSLAGSQQQLSLGLAGARQPGLPQPLMPTQ 3333



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 49/197 (24%), Positives = 71/197 (36%), Gaps = 14/197 (7%)

Query: 170  QRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSR 229
            Q+ Q +    L      L Q    + +Q QQQQQQQQ    +Q +     QQQQQQ ++ 
Sbjct: 3938 QQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVAL 3997

Query: 230  APGLITPGSP-----PPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQ------TMIP 278
             PG+  P  P      P      + ++   QNT   A           HQ         P
Sbjct: 3998 GPGM--PAKPLQHFSSPGALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGTTP 4055

Query: 279  HTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPS 338
             ++   P         DS    V  +   +  S +LQ  ++       ++      G  S
Sbjct: 4056 ESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQQQQVSLLHTAGGGS 4115

Query: 339  SADLGLGKAG-GKSVPH 354
               LG G +    SVPH
Sbjct: 4116 HGQLGSGSSSEASSVPH 4132



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 32/88 (36%), Positives = 39/88 (44%), Gaps = 2/88 (2%)

Query: 170  QRSQLEAYSTLLANMGSLSQTPGHKAEQQQ--QQQQQQQQQHQHQQQQQQQQQQQQQQHL 227
            Q+  +   S L  ++ S S  P   A+     QQ QQQQQ  Q QQ QQQQQQQ QQQ  
Sbjct: 3866 QQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQ 3925

Query: 228  SRAPGLITPGSPPPAQQNQYVHISSSPQ 255
             +   L         QQ Q   +    Q
Sbjct: 3926 LQQQQLQQQQQQQQLQQQQQQQLQQQQQ 3953



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 28/80 (35%), Positives = 39/80 (48%), Gaps = 24/80 (30%)

Query: 182  ANMGSLSQTPGHKAEQQQQQQQQQQQQHQH----------QQQQQQQQQQQQQQH----- 226
            A+   L      +++ Q+Q  Q ++QQ +H          QQQQQQQQQQQQQQH     
Sbjct: 3559 ADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQHSAVLA 3618

Query: 227  ---------LSRAPGLITPG 237
                     L++ PG + PG
Sbjct: 3619 LSPSQSPRLLTKLPGQLLPG 3638



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 47/161 (29%), Positives = 64/161 (39%), Gaps = 28/161 (17%)

Query: 181  LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQ--------QQQQQHLSRAPG 232
            L ++G  S+    +  Q QQQ+ Q  Q+ Q QQQQQQQQQ        QQQQQ   + PG
Sbjct: 3706 LRSLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQ---QGPG 3762

Query: 233  LITPGS---------PPPAQQNQYVHISS--SPQNTGRTASPPAIPVHLHPHQTMI---- 277
            + T  +         PP + Q   V   S   PQ       P  + V    H   +    
Sbjct: 3763 VQTNQALGPKPQGLMPPSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGPQG 3822

Query: 278  PHTLTLGPPSQVVM--QYADSGSHFVPREATKKAESSRLQQ 316
            PH   L   S+V+   Q A  G   +        +  + QQ
Sbjct: 3823 PHRQVLMTQSRVLSSPQLAQQGQGLMGHRLVTAQQQQQQQQ 3863



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 23/53 (43%), Positives = 32/53 (60%), Gaps = 7/53 (13%)

Query: 194  KAEQQQQQQQQQQQQH-------QHQQQQQQQQQQQQQQHLSRAPGLITPGSP 239
            K ++Q  Q ++QQ++H       +++QQQQQQQQQQQQQ  S    L    SP
Sbjct: 3573 KIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQHSAVLALSPSQSP 3625



 Score = 34.3 bits (77), Expect = 0.48
 Identities = 29/91 (31%), Positives = 31/91 (34%), Gaps = 36/91 (39%)

Query: 192  GHKAEQQQQQQQQQQQ------------------------------------QHQHQQQQ 215
            GH+    QQQQQQQQ                                     Q Q Q QQ
Sbjct: 3849 GHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQ 3908

Query: 216  QQQQQQQQQQHLSRAPGLITPGSPPPAQQNQ 246
            QQQ QQQQQQ L +   L         QQ Q
Sbjct: 3909 QQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQ 3939



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 36/165 (21%), Positives = 66/165 (40%), Gaps = 34/165 (20%)

Query: 90   PSAPRSVPVATTLPAAYATPQP-GTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLI 148
            P      P +T    A     P G+P+ P             GS+  S   +   P  ++
Sbjct: 2568 PGPTLGKPQSTNYTVATGNFHPSGSPLGPSS-----------GSTGESYGLSPLRPPSVL 2616

Query: 149  PPTANP-----VTSAVASAAGATTPSQRSQ------------LEAYSTLLANMGSLSQTP 191
            PP A       ++   +  +G T+P ++ +             E   T    M  LSQT 
Sbjct: 2617 PPPAPDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSLATAELPGTQDPGMSGLSQT- 2675

Query: 192  GHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITP 236
                E ++Q+Q+Q+ ++   +QQ Q+   +Q+++  + A G + P
Sbjct: 2676 ----ELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGP 2716


>gi|40354197 THAP domain containing 11 [Homo sapiens]
          Length = 314

 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 28/44 (63%), Positives = 32/44 (72%)

Query: 192 GHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLIT 235
           G  A +++QQQQQQQQQ Q QQQQQQQQQQQQQQ    +P   T
Sbjct: 96  GAAAARRRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSPSAST 139



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 26/43 (60%), Positives = 32/43 (74%)

Query: 183 NMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQ 225
           N   +++ P   A  +++QQQQQQQQ Q QQQQQQQQQQQQQQ
Sbjct: 86  NERKVARRPAGAAAARRRQQQQQQQQQQQQQQQQQQQQQQQQQ 128



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 26/35 (74%), Positives = 27/35 (77%)

Query: 196 EQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRA 230
           +QQQQQQQQQQQQ Q QQQQQQQQQQQ     S A
Sbjct: 106 QQQQQQQQQQQQQQQQQQQQQQQQQQQSSPSASTA 140



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 24/37 (64%), Positives = 28/37 (75%)

Query: 185 GSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQ 221
           G+ +     + +QQQQQQQQQQQQ Q QQQQQQQQQQ
Sbjct: 96  GAAAARRRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ 132



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 22/47 (46%), Positives = 26/47 (55%)

Query: 189 QTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLIT 235
           Q    + +QQQQQQQQQQQQ Q QQQQQ        Q     P L++
Sbjct: 105 QQQQQQQQQQQQQQQQQQQQQQQQQQQQSSPSASTAQTAQLQPNLVS 151



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 24/66 (36%), Positives = 28/66 (42%), Gaps = 12/66 (18%)

Query: 189 QTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLI------------TP 236
           Q    + +QQQQQQQQQQQQ Q        Q  Q Q +L  A   +             P
Sbjct: 111 QQQQQQQQQQQQQQQQQQQQQQSSPSASTAQTAQLQPNLVSASAAVLLTLQATVDSSQAP 170

Query: 237 GSPPPA 242
           GS  PA
Sbjct: 171 GSVQPA 176


>gi|32307128 nuclear receptor coactivator 6 [Homo sapiens]
          Length = 2063

 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 46/130 (35%), Positives = 57/130 (43%), Gaps = 34/130 (26%)

Query: 147 LIPPTANPVTSAVASAAGAT----TPSQRSQLEAYSTLLANM---------GSLSQTPGH 193
           +IPP  N  +S +A          TP   SQ +A   LL+ +         GSL+  P H
Sbjct: 183 MIPPGGNVSSSMMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLAP-PHH 241

Query: 194 --------------------KAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGL 233
                               + +QQQQQQQQQQQQ Q QQQQQQ Q +  QQH  + P  
Sbjct: 242 PMQPVSVNRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHQQQQPQG 301

Query: 234 ITPGSPPPAQ 243
           I P    P Q
Sbjct: 302 IRPQFTAPTQ 311



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 61/216 (28%), Positives = 79/216 (36%), Gaps = 44/216 (20%)

Query: 182 ANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPG---- 237
           AN   L Q    + +QQQQQQQQQQQQ Q Q Q +  QQ QQQQ     P    P     
Sbjct: 255 ANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHQQQQPQGIRPQFTAPTQVPV 314

Query: 238 ------------SPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGP 285
                        PPPAQ +    + +   N G   +P  +P  +       P   T+  
Sbjct: 315 PPGWNQLPSGALQPPPAQGS----LGTMTANQGWKKAP--LPGPMQQQLQARPSLATVQT 368

Query: 286 PSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLG 345
           PS     Y                     QQA QA      +M    ++ AP    L   
Sbjct: 369 PSHPPPPYPFGS-----------------QQASQAHTNF-PQMSNPGQFTAPQMKSL--- 407

Query: 346 KAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRAS 381
           + G   VP P +  H + + SP+   S    G  AS
Sbjct: 408 QGGPSRVPTPLQQPH-LTNKSPASSPSSFQQGSPAS 442



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 98/438 (22%), Positives = 150/438 (34%), Gaps = 52/438 (11%)

Query: 170  QRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQ------ 223
            QR   +    L+ ++    Q P  + + Q  QQQQ     Q Q QQQQQQQQQ       
Sbjct: 980  QRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQPPPPSQPQSQQQQQQQQQMMMMLMM 1039

Query: 224  -----------QQHLSRAPGLITPGSP-PPAQQNQYVHISSSPQNTGRTASPPAIPVHLH 271
                        Q++    G + P S   P QQ+  V +  S Q       P ++P    
Sbjct: 1040 QQDPKSVRLPVSQNVHPPRGPLNPDSQRMPMQQSGSVPVMVSLQ------GPASVPPSPD 1093

Query: 272  PHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQA--IQAKEVLNGEME 329
              +  +P    LG  S+  M Y +S  +     ++  AE + L +A   +A  V  G   
Sbjct: 1094 KQRMPMPVNTPLGSNSR-KMVYQESPQN---PSSSPLAEMASLPEASGSEAPSVPGGPNN 1149

Query: 330  KSRRYGAPSSADLGLGKAGGKSVPHPYES------RHVVVHPSPSDYSSRDPSGVRASVM 383
                   P +    L   G K  P P  +      +   V+  PS +    P+    +  
Sbjct: 1150 MPSHVVLPQNQ---LMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNVAAPTQT 1206

Query: 384  VLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEP 443
              P +   A+       T     PST   +  L   +       L P  +       + P
Sbjct: 1207 SRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAGLFPPQI-------NIP 1259

Query: 444  LP--VGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPL-LIPVGSTDME 500
            LP    L       G  P  +  +    QA +     P +   P T  L  + V S    
Sbjct: 1260 LPPRPNLNRGFDQQGLNPTTLKAIG---QAPSNLTMNPSNFATPQTHKLDSVVVNSGKQS 1316

Query: 501  ASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSV 560
             SGA      S+ + ++   +  TT  P  +N     L   +   A +   + LP    V
Sbjct: 1317 NSGATKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTNAALLQNVELPRNVLV 1376

Query: 561  ASPAAAPPTLPPYFMKGS 578
            +    A P +P  F   S
Sbjct: 1377 SPTPLANPPVPGSFPNNS 1394



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 95/491 (19%), Positives = 160/491 (32%), Gaps = 46/491 (9%)

Query: 20  PATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGTSVELGLQQGIGLHK 79
           P  +++ ++  P  P +N   +G      +PG        + P    V        G  +
Sbjct: 444 PTVNQTQQQMGPRPPQNNPLPQGFQQPVSSPGRNPMVQQGNVPPNFMVMQQQPPNQG-PQ 502

Query: 80  ALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTY 139
           +L  GL   P   P         P       P T  +    +  P   Q   + Q++G  
Sbjct: 503 SLHPGLGGMPKRLPPGFSAGQANPNFMQGQVPSTTATTPGNSGAPQ-LQANQNVQHAGGQ 561

Query: 140 ASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQ 199
            +  P   +  +  P      S  G        Q         N+ ++   P      Q 
Sbjct: 562 GAGPPQNQMQVSHGPPNMMQPSLMGIHGNMNNQQAGTSGVPQVNLSNMQGQPQQGPPSQL 621

Query: 200 QQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSP---PPAQQNQYVHISSSPQN 256
               QQ    Q Q  QQQ     Q   +     L+  G     PP+Q     ++  SPQ 
Sbjct: 622 MGMHQQIVPSQGQMVQQQGTLNPQNPMILSRAQLMPQGQMMVNPPSQ-----NLGPSPQR 676

Query: 257 TGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQ 316
                +PP   +     Q M PH   +GP  QV++Q     +  + +  T + + ++ Q 
Sbjct: 677 M----TPPKQMLSQQGPQMMAPHNQMMGPQGQVLLQQ----NPMIEQIMTNQMQGNKQQF 728

Query: 317 AIQ-AKEVLNGEMEKSRRYGAPSSADL--GLGKAGGKSVPHPYESRHVVVHPSPSDYSSR 373
             Q    V+ G  +  R        ++    G+  G+ +P             P + S  
Sbjct: 729 NTQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLP----------QQGPVNNSPS 778

Query: 374 DPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPG---HRSYALSP 430
              G++  V+  P  +   A      AT       T N+   L    P     ++  + P
Sbjct: 779 QVMGIQGQVLRPPGPSPHMAQQHGDPAT-------TANNDVSLSQMMPDVSIQQTNMVPP 831

Query: 431 HTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPL 490
           H      +SAS     G   +        P  G  +G Q +       P +  +  T PL
Sbjct: 832 HVQAMQGNSAS-----GNHFSGHGMSFNAPFSGAPNGNQMSCGQNPGFPVNKDVTLTSPL 886

Query: 491 LIPVGSTDMEA 501
           L+ +  +D+ A
Sbjct: 887 LVNLLQSDISA 897



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 85/375 (22%), Positives = 134/375 (35%), Gaps = 31/375 (8%)

Query: 188  SQTPGHKAEQQQQQ--QQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQN 245
            ++ PG+ ++  +Q+  QQ   Q  QH     Q  QQQ Q  L +      P  P   QQ 
Sbjct: 968  NRPPGYPSQPVEQRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQPPPPSQPQSQQQQ 1027

Query: 246  QYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQ-VVMQYADSGSHFV--- 301
            Q            +      +PV  + H    P    L P SQ + MQ + S    V   
Sbjct: 1028 QQQQQMMMMLMMQQDPKSVRLPVSQNVHPPRGP----LNPDSQRMPMQQSGSVPVMVSLQ 1083

Query: 302  -PREATKKAESSRLQQAIQAKEVLNG-EMEKSRRYGAPSSADLGLGKAGGKSVPHPYESR 359
             P       +  R+   +      N  +M        PSS+ L    A   S+P    S 
Sbjct: 1084 GPASVPPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNPSSSPL----AEMASLPEASGSE 1139

Query: 360  HVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLG 419
               V   P++  S         +M  P    P+     Q AT ++   ++L    G H  
Sbjct: 1140 APSVPGGPNNMPSHVVLPQNQLMMTGPKPG-PSPLSATQGATPQQPPVNSLPSSHGHHFP 1198

Query: 420  KPGHRSYALSPHTVIQTTHSASEP-LPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSL 478
                 +    P T  + +     P  P   P +     T+P  I  LS ++   + AG  
Sbjct: 1199 NVAAPTQTSRPKTPNRASPRPYYPQTPNNRPPS-----TEPSEIS-LSPERLNASIAGLF 1252

Query: 479  PQHLVIP-GTQPLL------IPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSE 531
            P  + IP   +P L        +  T ++A G AP+ +T +P   A P T    ++  + 
Sbjct: 1253 PPQINIPLPPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTMNPSNFATPQTHKLDSVVVNS 1312

Query: 532  NFNPEALVTQAAYPA 546
                 +  T+ A P+
Sbjct: 1313 GKQSNSGATKRASPS 1327



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 40/164 (24%), Positives = 66/164 (40%), Gaps = 20/164 (12%)

Query: 301 VPREATKK----AESSR--------LQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAG 348
           +PREA ++    A+S+         L   I+ +  +N  + ++R      +  +G G + 
Sbjct: 100 IPREAAERLRILAQSNNQQLRDLGILSVQIEGEGAINLALAQNRSQDVRMNGPMGAGNSV 159

Query: 349 GKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPS 408
                 P  S   ++  +        P G  +S M+ P  N      E+Q  T R AS S
Sbjct: 160 RMEAGFPMASGPGIIRMNNPATVMIPPGGNVSSSMMAPGPNP-----ELQPRTPRPASQS 214

Query: 409 TLNDK--SGLHLGKPGHRSYALS-PHTVIQTTHSASEPLPVGLP 449
              D   SGLH+ +  H S +L+ PH  +Q      +  P   P
Sbjct: 215 DAMDPLLSGLHIQQQSHPSGSLAPPHHPMQPVSVNRQMNPANFP 258



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 68/316 (21%), Positives = 104/316 (32%), Gaps = 59/316 (18%)

Query: 83   TGLDYSPPSAP----RSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGS------ 132
            T L+ +PP       +   V  TL    ++ +P   ++      LPH+ +   S      
Sbjct: 1511 TDLEVTPPVVSGEDLKKASVIPTLQDLSSSKEPSNSLN------LPHSNELCSSLVHPEL 1564

Query: 133  SQYSGTYASFIP------------SQLIPP-------TANPVTSAVASAAGATTPSQRSQ 173
            S+ S   A  IP            S  +PP       T+NP+T++  ++A   T  Q + 
Sbjct: 1565 SEVSSNVAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSANTSAALPTHLQSAL 1624

Query: 174  LEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGL 233
            +    T+      +  + G  A Q   + Q       +     Q  +  Q   +  AP  
Sbjct: 1625 MSTVVTMPNAGSKVMVSEGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPSTIPAAPLT 1684

Query: 234  ITPGSPPPA-------QQNQYVHISSSPQNTGRTASPP---------------AIPVHL- 270
               G  PP+          Q +  SS+P      +S P               A PV L 
Sbjct: 1685 TNSGLMPPSVAVVGPLHIPQNIKFSSAPVPPNALSSSPAPNIQTGRPLVLSSRATPVQLP 1744

Query: 271  HPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEK 330
             P  T  P   +  P  QV     D  S  V   A +    S  Q       +L      
Sbjct: 1745 SPPCTSSPVVPSHPPVQQVKELNPDEASPQVNTSADQNTLPSS-QSTTMVSPLLTNSPGS 1803

Query: 331  SRRYGAPSSADLGLGK 346
            S    +P S+  G GK
Sbjct: 1804 SGNRRSPVSSSKGKGK 1819


>gi|51702521 POU domain, class 3, transcription factor 2 [Homo
           sapiens]
          Length = 443

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 50/158 (31%), Positives = 58/158 (36%), Gaps = 49/158 (31%)

Query: 198 QQQQQQQQQQQHQHQQQQQQQQQQQQQQHL-----SRAPGLITPGSPPPAQQNQYVHISS 252
           QQQ QQQQQQQ Q QQQQQQQQQQQ+  HL     +  PG   PG+   A    ++  S 
Sbjct: 125 QQQHQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPG---PGAWRSAAAAAHLPPSM 181

Query: 253 SPQNTGRTASPPAIPV----------------------------------HLHPHQTMIP 278
              N G   S P+  V                                  H HPHQ   P
Sbjct: 182 GASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPP 241

Query: 279 HTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQ 316
                GPP          G+H  P        S  L+Q
Sbjct: 242 PPPPQGPPGH-------PGAHHDPHSDEDTPTSDDLEQ 272


>gi|10863899 numb homolog (Drosophila)-like [Homo sapiens]
          Length = 609

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 86/319 (26%), Positives = 116/319 (36%), Gaps = 45/319 (14%)

Query: 14  PKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGN--PGGRGHGGGRHGPAGTSVELGL 71
           P +RE P   ++    APT+        G A  PG+  P       G  G AGT V  G 
Sbjct: 233 PAEREAPDKKKAEAAAAPTV------APGPAQ-PGHVSPTPATTSPGEKGEAGTPVAAGT 285

Query: 72  QQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIG 131
                   A +    ++P             PA      P      ++   LP T Q   
Sbjct: 286 T-------AAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRT 338

Query: 132 SSQYSGTYASFIP-----SQLIPPTANPVTSAVASAAGATT--PSQRSQLEAYSTLLANM 184
             Q  GT     P     S  I      ++S+ ASA       P   +   A+       
Sbjct: 339 DFQVKGTVPEMEPPGAGDSDSINALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPP 398

Query: 185 GSLSQTPGHKAE--------QQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITP 236
            +  Q PGHK          ++  Q  + QQQ Q QQQQQQQQQQQQQQ  S AP    P
Sbjct: 399 AAAFQ-PGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQAASVAPVPTMP 457

Query: 237 GS--PPPAQQNQY------VHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLG-PPS 287
            +  P PA    +      V +   P +      PP +P +       +P    +G  PS
Sbjct: 458 PALQPFPAPVGPFDAAPAQVAVFLPPPH----MQPPFVPAYPGLGYPPMPRVPVVGITPS 513

Query: 288 QVVMQYADSGSHFVPREAT 306
           Q+V     S +   P+ AT
Sbjct: 514 QMVANAFCSAAQLQPQPAT 532


>gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]
          Length = 788

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 79/297 (26%), Positives = 110/297 (37%), Gaps = 59/297 (19%)

Query: 193 HKAEQQQQQQQQQQQ-----QHQHQQQQQQQQQQQQQQHLSRAPGLITPG----SPPPAQ 243
           H+ +QQ QQQQQQ Q     Q Q QQQQQQQQQQQQQQ L   P +  P      PPP+Q
Sbjct: 225 HQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQ 284

Query: 244 ----QNQYVHISSSPQNTGRTASPPAI---PVHLHPHQTMIP----------HTLTLGPP 286
               Q Q +H +   Q   +   PP     P  L P     P            L   PP
Sbjct: 285 ALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPP 344

Query: 287 SQVVMQYADSGSHFVPREATKKAESSRLQQAIQ---------AKEVLNGEMEKSRRY--- 334
            + V          V  +  ++  + +  QA Q          + +  G M    R+   
Sbjct: 345 LKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPT 404

Query: 335 ---GAPSSADLGLGK-----AGGKSVP---HPYESRHVVV----------HPSPSDYSSR 373
               A  S+ + LG+         S+P    P   + V             P P   SS+
Sbjct: 405 TAVSAIPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQ 464

Query: 374 DPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSP 430
             S V +     P+S  P+   +  Q+     +P   +  S   L  P + S  +SP
Sbjct: 465 PNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSP 521



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 34/65 (52%), Positives = 36/65 (55%), Gaps = 2/65 (3%)

Query: 193 HKAEQQQQQQQQQQQQH--QHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHI 250
           H   QQQ QQQQQQ Q   Q Q QQQQQQQQQQQQ   +A     P   PP QQ Q    
Sbjct: 224 HHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPS 283

Query: 251 SSSPQ 255
            + PQ
Sbjct: 284 QALPQ 288



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 93/427 (21%), Positives = 142/427 (33%), Gaps = 111/427 (25%)

Query: 154 PVTSAVA--SAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQH 211
           P TS +A  S A  +T + ++QL+     L               QQQQQQQQ QQQ Q 
Sbjct: 131 PGTSGMAPHSMAVVSTATPQTQLQLQQVAL---------------QQQQQQQQFQQQQQA 175

Query: 212 QQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLH 271
             QQQQQQQQQQQ    ++           A Q Q+  +    Q              L 
Sbjct: 176 ALQQQQQQQQQQQFQAQQS-----------AMQQQFQAVVQQQQ-------------QLQ 211

Query: 272 PHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGE---M 328
             Q    H + L   +Q  +Q        + +   ++ +  + QQ  Q ++ L  +    
Sbjct: 212 QQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQ 271

Query: 329 EKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNS 388
           +   +   P  +         +++P   +  H   H  P     + P        + P S
Sbjct: 272 QPPMQQPQPPPS---------QALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQS 322

Query: 389 NTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGL 448
            T     + Q                      PG   Y   P   ++       P+ V  
Sbjct: 323 QTQPLVSQAQ--------------------ALPGQMLYTQPPLKFVRA------PMVV-- 354

Query: 449 PATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAI 508
                    QPPV   +  QQ A+  A +    +V PG Q +   +    M         
Sbjct: 355 --------QQPPVQPQVQQQQTAVQTAQA--AQMVAPGVQMITEALAQGGMHIR------ 398

Query: 509 VTSSPQFAAVPHTFVTTALPKSE---NFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAA 565
                  A  P T   +A+P S       P A V+Q++ P +          Q V +P +
Sbjct: 399 -------ARFPPTTAVSAIPSSSIPLGRQPMAQVSQSSLPMLSSPS----PGQQVQTPQS 447

Query: 566 APPTLPP 572
            PP   P
Sbjct: 448 MPPPPQP 454



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 35/91 (38%), Positives = 41/91 (45%), Gaps = 12/91 (13%)

Query: 149 PPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQ- 207
           PP  + +     +     TP  + QL+  +          Q     A QQQQQQQQQQQ 
Sbjct: 130 PPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQF 189

Query: 208 -----------QHQHQQQQQQQQQQQQQQHL 227
                      Q   QQQQQ QQQQQQQQHL
Sbjct: 190 QAQQSAMQQQFQAVVQQQQQLQQQQQQQQHL 220



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 42/185 (22%), Positives = 78/185 (42%), Gaps = 29/185 (15%)

Query: 93  PRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTA 152
           P+S+P     P    +PQPG P S       P++     SS  + + +SF+PS    P+ 
Sbjct: 445 PQSMP-----PPPQPSPQPGQPSSQ------PNSNV---SSGPAPSPSSFLPSPSPQPSQ 490

Query: 153 NPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQ 212
           +PVT+         +P   +     S++++  GS       +AE+QQ   + +Q     +
Sbjct: 491 SPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGS------SQAEEQQYLDKLKQLSKYIE 544

Query: 213 QQQQQ----QQQQQQQQHLSRAPGLI----TPGSPPPAQQNQYVHIS-SSPQNTGRTASP 263
             ++      + + +++ LS+   L+     P    P +  Q   I+    +N     +P
Sbjct: 545 PLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTP 604

Query: 264 PAIPV 268
           P  PV
Sbjct: 605 PPPPV 609


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.127    0.368 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,433,772
Number of Sequences: 37866
Number of extensions: 2080322
Number of successful extensions: 27633
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 302
Number of HSP's successfully gapped in prelim test: 465
Number of HSP's that attempted gapping in prelim test: 12883
Number of HSP's gapped (non-prelim): 6087
length of query: 815
length of database: 18,247,518
effective HSP length: 111
effective length of query: 704
effective length of database: 14,044,392
effective search space: 9887251968
effective search space used: 9887251968
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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