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Search of human proteins with 51317373
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|51317373 netrin-G1 ligand [Homo sapiens]
(640 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|51317373 netrin-G1 ligand [Homo sapiens] 1299 0.0
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 810 0.0
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 712 0.0
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 184 3e-46
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 182 6e-46
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 168 1e-41
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 161 2e-39
gi|153251229 chondroadherin precursor [Homo sapiens] 154 2e-37
gi|31542244 leucine rich repeat and fibronectin type III domain ... 149 1e-35
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 148 1e-35
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 148 1e-35
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 148 1e-35
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 146 7e-35
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 146 7e-35
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 144 3e-34
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens] 140 5e-33
gi|55741571 leucine rich repeat and fibronectin type III domain ... 137 2e-32
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom... 134 2e-31
gi|198041768 synleurin [Homo sapiens] 134 3e-31
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho... 134 3e-31
gi|149773484 leucine rich repeat and fibronectin type III domain... 133 6e-31
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 132 7e-31
gi|88702793 slit-like 2 [Homo sapiens] 132 1e-30
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 131 2e-30
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 131 2e-30
gi|126517478 peroxidasin homolog-like [Homo sapiens] 130 3e-30
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 129 6e-30
gi|194440719 chondroadherin-like [Homo sapiens] 129 6e-30
gi|13375646 leucine rich repeat and fibronectin type III domain ... 129 8e-30
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre... 128 1e-29
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 1299 bits (3362), Expect = 0.0
Identities = 640/640 (100%), Positives = 640/640 (100%)
Query: 1 MLNKMTLHPQQIMIGPRFNRALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKV 60
MLNKMTLHPQQIMIGPRFNRALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKV
Sbjct: 1 MLNKMTLHPQQIMIGPRFNRALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKV 60
Query: 61 ICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAF 120
ICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAF
Sbjct: 61 ICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAF 120
Query: 121 NGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLG 180
NGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLG
Sbjct: 121 NGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLG 180
Query: 181 ELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQ 240
ELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQ
Sbjct: 181 ELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQ 240
Query: 241 GLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHH 300
GLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHH
Sbjct: 241 GLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHH 300
Query: 301 NPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPP 360
NPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPP
Sbjct: 301 NPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPP 360
Query: 361 ADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQD 420
ADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQD
Sbjct: 361 ADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQD 420
Query: 421 TGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTP 480
TGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTP
Sbjct: 421 TGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTP 480
Query: 481 VVDWETTNVTTSLTPQSTRSTEKTFTIPVTDINSGIPGIDEVMKTTKIIIGCFVAITLMA 540
VVDWETTNVTTSLTPQSTRSTEKTFTIPVTDINSGIPGIDEVMKTTKIIIGCFVAITLMA
Sbjct: 481 VVDWETTNVTTSLTPQSTRSTEKTFTIPVTDINSGIPGIDEVMKTTKIIIGCFVAITLMA 540
Query: 541 AVMLVIFYKMRKQHHRQNHHAPTRTVEIINVDDEITGDTPMESHLPMPAIEHEHLNHYNS 600
AVMLVIFYKMRKQHHRQNHHAPTRTVEIINVDDEITGDTPMESHLPMPAIEHEHLNHYNS
Sbjct: 541 AVMLVIFYKMRKQHHRQNHHAPTRTVEIINVDDEITGDTPMESHLPMPAIEHEHLNHYNS 600
Query: 601 YKSPFNHTTTVNTINSIHSSVHEPLLIRMNSKDNVQETQI 640
YKSPFNHTTTVNTINSIHSSVHEPLLIRMNSKDNVQETQI
Sbjct: 601 YKSPFNHTTTVNTINSIHSSVHEPLLIRMNSKDNVQETQI 640
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 810 bits (2091), Expect = 0.0
Identities = 406/660 (61%), Positives = 485/660 (73%), Gaps = 63/660 (9%)
Query: 44 AQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLE 103
A +CP CSCSNQ S+VIC R++L EVP I NTR LNL EN IQ+I+ ++FKHLRHLE
Sbjct: 54 ATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLE 113
Query: 104 ILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESI 163
ILQLS+N +R IE+GAFNGL +LNTLELFDNRLTT+P AF YLSKL+ELWLRNNPIESI
Sbjct: 114 ILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESI 173
Query: 164 PSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDE 223
PSYAFNR+PSLRRLDLGELKRL YISE AFEGL NLRYLNL MCNL++IPNLT L++L+E
Sbjct: 174 PSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEE 233
Query: 224 LDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLP 283
L+LSGN L IRPGSFQGL L+KLW++ +Q+ IERNAFD+L+SL E+NL+HNNL LP
Sbjct: 234 LELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLP 293
Query: 284 HDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGE 343
HDLFTPLH LER+HL+HNPW+CNCD+LWLSWW+K+ PSNT CCARC+ P LKGRYIGE
Sbjct: 294 HDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGE 353
Query: 344 LDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRI 403
LDQ++FTCYAPVIVEPP DLNVTEGMAAELKCR TS+TSV+W+TPNGT+MTHG+Y+VRI
Sbjct: 354 LDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWLTPNGTLMTHGSYRVRI 413
Query: 404 AVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTP------------- 450
+VL DGTLNFTNVTVQDTG YTCMV+NS GNTTASATLNV+A
Sbjct: 414 SVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGTGSGGGGPGG 473
Query: 451 ----------FSYFSTVTVETMEPSQDEAR-----TTDNNVGPTPVVDW----------E 485
++YF+TVTVET+E E T GPT W
Sbjct: 474 SGGVGGGSGGYTYFTTVTVETLETQPGEEALQPRGTEKEPPGPTTDGVWGGGRPGDAAGP 533
Query: 486 TTNVTTSLTPQSTRSTEKTFTIPVTDI-NSGIPGIDEVMKTTKIIIGCFVAITLMAAVML 544
++ TT+ P+S+R TEK FT+P+TD+ + + +D+VMKTTKIIIGCFVAIT MAAVML
Sbjct: 534 ASSSTTAPAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKIIIGCFVAITFMAAVML 593
Query: 545 VIFYKMRKQHHRQNHHAPTRTVEIINVDDEIT----------------GDTPMESHLPMP 588
V FYK+RKQH HH PTRTVEIINV+DE+ G +SHL +P
Sbjct: 594 VAFYKLRKQHQLHKHHGPTRTVEIINVEDELPAASAVSVAAAAAVASGGGVGGDSHLALP 653
Query: 589 AIEHEHLNHYNSYKSPFNHTTTVNTINS--------IHSSVHEPLLIRMNSKDNVQETQI 640
A+E +HLNH++ + F + N +S+HEPLL + SK+NVQETQI
Sbjct: 654 ALERDHLNHHHYVAAAFKAHYSSNPSGGGCGGKGPPGLNSIHEPLLFKSGSKENVQETQI 713
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 712 bits (1839), Expect = 0.0
Identities = 356/636 (55%), Positives = 465/636 (73%), Gaps = 28/636 (4%)
Query: 29 VLLALQLLVVAGLVRA------QTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLN 82
V L Q+ ++ + A Q CPSVCSCSNQFSKV+C R+ L EVP GI +NTR LN
Sbjct: 22 VYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLN 81
Query: 83 LHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNG 142
L EN IQ+I+ ++F+HL HLE+LQL RN IR IE+GAFNGLA+LNTLELFDN LT IP+G
Sbjct: 82 LMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSG 141
Query: 143 AFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYL 202
AF YLSKL+ELWLRNNPIESIPSYAFNR+PSL RLDLGELK+L YISEGAFEGL NL+YL
Sbjct: 142 AFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYL 201
Query: 203 NLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNA 262
NL MCN++++PNLTPL+ L+EL++SGNH IRPGSF GL L+KLW++ SQ+ +IERNA
Sbjct: 202 NLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNA 261
Query: 263 FDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPS 322
FD L SLVE+NLAHNNL+ LPHDLFTPL +L +HLHHNPWNC+CDILWL+WW+++ P+
Sbjct: 262 FDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPT 321
Query: 323 NTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLT 382
N+ CC RC+ P +++GRY+ E+DQ F C AP I++ P DLN++EG AELKCR + ++
Sbjct: 322 NSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCR-TPPMS 380
Query: 383 SVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLN 442
SV W+ PNGTV++H + RI+VL+DGTLNF++V + DTG+YTCMV+N GN+ ASA LN
Sbjct: 381 SVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLN 440
Query: 443 VTAA--TTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVVDWETTNVTTSLTPQSTRS 500
V+ A T+ +S+F+TVTVET E S ++ T PT ++ T++ T
Sbjct: 441 VSTAELNTSNYSFFTTVTVETTEISPEDT-TRKYKPVPTTSTGYQPAYTTSTTVLIQTTR 499
Query: 501 TEKTFTIPVTDINSGI-PGIDEVMKTTKIIIGCFVAITLMAAVMLVIFYKMRKQHHRQNH 559
K +P TD + +DEVMKTTKIIIGCFVA+TL+AA ML++FYK+RK+H +++
Sbjct: 500 VPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRST 559
Query: 560 HAPTRTVEIINVDDEITGDTPM-----------ESHLPMPAIEHEHLNHYNSYKSPFNHT 608
RTVEII VD++I T E + +P I H+H+N YN+YK
Sbjct: 560 VTAARTVEIIQVDEDIPAATSAAATAAPSGVSGEGAVVLPTI-HDHIN-YNTYKPAHGAH 617
Query: 609 TTVNTI-NSIH---SSVHEPLLIRMNSKDNVQETQI 640
T N++ NS+H +++ EP +I+ ++KD VQETQI
Sbjct: 618 WTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI 653
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 184 bits (466), Expect = 3e-46
Identities = 159/560 (28%), Positives = 248/560 (44%), Gaps = 95/560 (16%)
Query: 20 RALFDPLLVVLLALQLLVVAGLVR--AQTCPSVCSCSNQFSKVICVRKNLREVPDGISTN 77
R++ PLL + LLV+ ++ A CP C CS Q V+C RK VP+GI T
Sbjct: 13 RSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTE 72
Query: 78 TRLLNLHENQIQIIKVNSFKHLRHLEILQLSRN------------------------HIR 113
TRLL+L +N+I+ + + F HLE L+L+ N ++
Sbjct: 73 TRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLK 132
Query: 114 TIEIGAFNGLANLNTLELFDNR-------------------------------------- 135
I +G F GL+NL L++ +N+
Sbjct: 133 LIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNS 192
Query: 136 ----------LTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRL 185
LT+IP A +L L L LR+ I +I Y+F R+ L+ L++ L
Sbjct: 193 LEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYL 252
Query: 186 SYISEGAFEGLSNLRYLNLAMCNLREIPNLTP--LIKLDELDLSGNHLSAIRPGSFQGLM 243
++ GL NL L++ CNL +P L L+ L L+LS N +S I L+
Sbjct: 253 DTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELL 311
Query: 244 HLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPW 303
LQ++ ++ Q+ V+E AF L L +N++ N LT L +F + +LE + L NP
Sbjct: 312 RLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPL 371
Query: 304 NCNCDILWL---SWWIKDMAPSNTACCARCNTPPNLKGRYIGE----LDQNYFTCYAPVI 356
C+C +LW+ W + T C TP ++G+ + L NYFTC I
Sbjct: 372 ACDCRLLWVFRRRWRLNFNRQQPT-----CATPEFVQGKEFKDFPDVLLPNYFTCRRARI 426
Query: 357 VEPPA-DLNVTEGMAAELKCRA-STSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFT 414
+ A + V EG + CRA ++ W++P +++ R+ V DGTL
Sbjct: 427 RDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVS-AKSNGRLTVFPDGTLEVR 485
Query: 415 NVTVQDTGMYTCMVSNSVGNTTASATLNVTA-ATTTPFSYFSTVTVETMEPSQDEARTTD 473
VQD G Y C+ +N+ GN + A L+V + + P T + +P + EA +T
Sbjct: 486 YAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTR 545
Query: 474 NNVGPTPVVDWETTNVTTSL 493
V P P D +T + T++
Sbjct: 546 ATV-PFP-FDIKTLIIATTM 563
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 182 bits (463), Expect = 6e-46
Identities = 143/527 (27%), Positives = 236/527 (44%), Gaps = 87/527 (16%)
Query: 47 CPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQII--------------- 91
CP+ C CS Q V C R+ L +P+GI T++L+L +N+++ +
Sbjct: 28 CPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEID 87
Query: 92 ---------KVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNR------- 135
+ +F +L +L L+L N ++ + +G F GL+NL L++ +N+
Sbjct: 88 LSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDY 147
Query: 136 -----------------------------------------LTTIPNGAFVYLSKLKELW 154
LT +P A +L L L
Sbjct: 148 MFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLH 207
Query: 155 LRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPN 214
L++ I ++P YAF R+ L+ L++ L + + GL NL L++ NL +P
Sbjct: 208 LKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGL-NLTSLSVTNTNLSTVPF 266
Query: 215 LT--PLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEI 272
L L+ L L+LS N +S I G F L+ LQ+L ++ +Q++ IE ++F L+ L +
Sbjct: 267 LAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVL 326
Query: 273 NLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNT 332
N++ N L L ++F+ LE + +++NP C+C +LW+ + C
Sbjct: 327 NVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQRQPTLQFGGQQ--PMCAG 384
Query: 333 PPNLKGRYIGELDQN----YFTCYAPVIVEPPAD-LNVTEGMAAELKCRASTSLTSV-SW 386
P ++ R + YFTC P I E L V EG +L+C A V SW
Sbjct: 385 PDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISW 444
Query: 387 ITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAA 446
+TP +T + R VL DGTL QD+GMY C+ SN+ GN T +A+L V
Sbjct: 445 VTPRRRFITTKS-NGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGF 503
Query: 447 TTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVVDWETTNVTTSL 493
+ F Y + + + + + T+ N T +D +T V+T++
Sbjct: 504 ASDRFLYANRTPMYMTDSNDTISNGTNAN---TFSLDLKTILVSTAM 547
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 168 bits (426), Expect = 1e-41
Identities = 145/507 (28%), Positives = 216/507 (42%), Gaps = 87/507 (17%)
Query: 27 LVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHEN 86
L VL LL+ A A CP+ C C+ Q V C R+ L VPDGI TRLL L N
Sbjct: 5 LCVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRN 64
Query: 87 QIQI------------------------IKVNSFKHLRHLEILQLSRNHIRTIEIGAFNG 122
+I+ ++ +F +L L +L+L N ++ I G F
Sbjct: 65 RIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTR 124
Query: 123 LANLNTLELFDNRL---------------------------------------------- 136
L NL L+L +N+L
Sbjct: 125 LDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERC 184
Query: 137 --TTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFE 194
T + + +L L L LR+ I S+ F R+P L L++ L ++ G+
Sbjct: 185 NLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLR 244
Query: 195 GLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQ 252
GL NL L++ N+ +P L L L+LS N +S + GSF+ L+ L++L +
Sbjct: 245 GL-NLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAG 303
Query: 253 SQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWL 312
+ + V+E AF L+ + +NL++N L+ L F ++ LE + + NP C+C +LW+
Sbjct: 304 ALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWI 363
Query: 313 SWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQN----YFTCYAPVIVEPPAD-LNVTE 367
K + + C TP ++G + L + YF C P I E + T
Sbjct: 364 VQRRKTL--NFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTATA 421
Query: 368 GMAAELKCRA-STSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTC 426
G CRA +V+W+TP +T R VL GTL + QD+G YTC
Sbjct: 422 GEDVRFLCRAEGEPAPTVAWVTPQHRPVT-ATSAGRARVLPGGTLEIQDARPQDSGTYTC 480
Query: 427 MVSNSVGNTTASATLNV---TAATTTP 450
+ SN+ GN T ATL V AA TP
Sbjct: 481 VASNAGGNDTYFATLTVRPEPAANRTP 507
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 161 bits (407), Expect = 2e-39
Identities = 142/480 (29%), Positives = 207/480 (43%), Gaps = 90/480 (18%)
Query: 46 TCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEIL 105
+CP+VC C++Q V+C + L VP G+ +T LL+L N++ ++ L L+ L
Sbjct: 30 SCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQEL 89
Query: 106 QLSRNHIRTIEIGAFNGLANLNTL------------------------------------ 129
LS N + T+E GAF+GL +L TL
Sbjct: 90 DLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLD 149
Query: 130 ------------ELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSL--- 174
E+ DN L + GAF L+KL L L + ++P A R+P+L
Sbjct: 150 GAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVAL 209
Query: 175 --RRLD-----------LGELKRLSY--------ISEGAFEGLSNLRYLNLAMCNLREIP 213
R LD LG+LK L + G+ GL NL L + CNL +P
Sbjct: 210 RLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGL-NLSSLAITRCNLSSVP 268
Query: 214 --NLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVE 271
L L L LDLS N +SAI L+ LQ+L + + + I +AF L +
Sbjct: 269 FQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHL 328
Query: 272 INLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIK--DMAPSNTACCAR 329
+++A N L L F L + L NP C+C +LWL + D S AC
Sbjct: 329 LDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAG- 387
Query: 330 CNTPPNLKGRYIGE----LDQNYFTCYAPVIVEP-PADLNVTEGMAAELKCRA-STSLTS 383
P +++G+ + E L +FTC +I + P + EG A C +
Sbjct: 388 ---PHHVQGKSLKEFSDILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPT 444
Query: 384 VSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNV 443
VSW+ P+G + R+ VL DGTL +V ++D G Y C+VSN GN + L V
Sbjct: 445 VSWMRPHGAWLGRAG---RVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEV 501
>gi|153251229 chondroadherin precursor [Homo sapiens]
Length = 359
Score = 154 bits (390), Expect = 2e-37
Identities = 111/344 (32%), Positives = 166/344 (48%), Gaps = 35/344 (10%)
Query: 30 LLALQLLVVAGLVRA-QTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQI 88
+L L L ++AGL+ A CP C C + VIC + L+++P +S T+LLNL N
Sbjct: 5 MLLLSLGLLAGLLPALAACPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNF 63
Query: 89 QIIKVNSFK--------HLRHLEI----------------LQLSRNHIRTIEIGAFNGLA 124
++ NSF+ HL+H +I L LS N IR + GAF+ L
Sbjct: 64 PVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLT 123
Query: 125 NLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKR 184
L L L N++T +P G L L L L NN I + + AF LR L L E
Sbjct: 124 ELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSE-NA 182
Query: 185 LSYISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGL 242
LS + GA + + NL ++ L P+ L+ L ++EL LS N L +I +FQ
Sbjct: 183 LSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSF 242
Query: 243 -MHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
+L+ LW+ + ++ AF + +L ++L +N L LP + P LE + L +N
Sbjct: 243 GRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNF--PFDSLETLALTNN 300
Query: 302 PWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELD 345
PW C C + L W++ A A CA +P KG++I + D
Sbjct: 301 PWKCTCQLRGLRRWLEAKASRPDATCA---SPAKFKGQHIRDTD 341
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 149 bits (375), Expect = 1e-35
Identities = 136/503 (27%), Positives = 205/503 (40%), Gaps = 84/503 (16%)
Query: 35 LLVVAGLVRAQTCPSVCSCS--NQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIK 92
L ++ V+AQ CP C C + +C +K L VP I
Sbjct: 8 LFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDR---------------- 51
Query: 93 VNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKE 152
RT+E L L DN +T I F ++ L +
Sbjct: 52 --------------------RTVE------------LRLADNFVTNIKRKDFANMTSLVD 79
Query: 153 LWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREI 212
L L N I I +AF + +LR L L RL+ I+ F GLSNL +L L L I
Sbjct: 80 LTLSRNTISFITPHAFADLRNLRALHLNS-NRLTKITNDMFSGLSNLHHLILNNNQLTLI 138
Query: 213 PNLT--PLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLV 270
+ + L+ELDLS N+L I + + ++ L L + + I I + F +L +
Sbjct: 139 SSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMT 198
Query: 271 EINLAHNNLTLLPHD-LFTPLHHLER----------IHLHHNPWNCNCDILWLSWWIKDM 319
+++ N L LP D LF L + NP +CNC++LWL
Sbjct: 199 RLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLR------ 252
Query: 320 APSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRA-S 378
S C +PP L GRY + + F C P+I ++ V EG A L+C+A
Sbjct: 253 RLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARG 312
Query: 379 TSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTAS 438
++ WI+P G ++++ R V +GTL+ TV+DTG +TC+ SN G T
Sbjct: 313 DPEPAIHWISPEGKLISNA---TRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQI 369
Query: 439 ATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVVDWETTNVTTSLTPQST 498
L++ P ST + +P + T+ + T ++N T L+
Sbjct: 370 VDLHI---IKLPHLLNSTNHIHEPDPGSSDISTSTKSGSNT-----SSSNGDTKLSQDKI 421
Query: 499 RSTEKTFTIPVTDIN--SGIPGI 519
E T + + N IPGI
Sbjct: 422 VVAEATSSTALLKFNFQRNIPGI 444
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 148 bits (374), Expect = 1e-35
Identities = 120/413 (29%), Positives = 193/413 (46%), Gaps = 45/413 (10%)
Query: 66 NLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLAN 125
N++++P +S + L EN++ + L +L+ L ++ N + TI GAF GL N
Sbjct: 111 NVKKMPQLLS-----VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHN 165
Query: 126 LNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRL 185
L L L NRL I + F L L+ L + NPI I F + +LR L + + L
Sbjct: 166 LLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGI-NL 224
Query: 186 SYISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGLM 243
+ I + A GL NL ++ L ++P+ L ++ L LDL+ N ++ IR G F ++
Sbjct: 225 TEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNML 284
Query: 244 HLQKLWM--------IQS------------------QIQVIERNAFDNLQSLVEINLAHN 277
HL++L + I S ++ I NAF L L + L N
Sbjct: 285 HLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSN 344
Query: 278 NLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSW---WIKDMAPSNTACCARCNTPP 334
L+ L H L +L+ I +H NP C+C I W++ I+ M P + C PP
Sbjct: 345 ALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCV----DPP 400
Query: 335 NLKGRYIGELD-QNYFTCYAPVIVEP--PADLNVTEGMAAELKCRASTS-LTSVSWITPN 390
+G+ + ++ ++ P+I P++LNV G CRA+ + WITP+
Sbjct: 401 EFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPS 460
Query: 391 GTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNV 443
G + + V S+GTL+ VT ++ G+YTC+ +N VG S + V
Sbjct: 461 GQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKV 513
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 148 bits (374), Expect = 1e-35
Identities = 120/413 (29%), Positives = 193/413 (46%), Gaps = 45/413 (10%)
Query: 66 NLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLAN 125
N++++P +S + L EN++ + L +L+ L ++ N + TI GAF GL N
Sbjct: 111 NVKKMPQLLS-----VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHN 165
Query: 126 LNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRL 185
L L L NRL I + F L L+ L + NPI I F + +LR L + + L
Sbjct: 166 LLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGI-NL 224
Query: 186 SYISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGLM 243
+ I + A GL NL ++ L ++P+ L ++ L LDL+ N ++ IR G F ++
Sbjct: 225 TEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNML 284
Query: 244 HLQKLWM--------IQS------------------QIQVIERNAFDNLQSLVEINLAHN 277
HL++L + I S ++ I NAF L L + L N
Sbjct: 285 HLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSN 344
Query: 278 NLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSW---WIKDMAPSNTACCARCNTPP 334
L+ L H L +L+ I +H NP C+C I W++ I+ M P + C PP
Sbjct: 345 ALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCV----DPP 400
Query: 335 NLKGRYIGELD-QNYFTCYAPVIVEP--PADLNVTEGMAAELKCRASTS-LTSVSWITPN 390
+G+ + ++ ++ P+I P++LNV G CRA+ + WITP+
Sbjct: 401 EFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPS 460
Query: 391 GTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNV 443
G + + V S+GTL+ VT ++ G+YTC+ +N VG S + V
Sbjct: 461 GQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKV 513
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 148 bits (374), Expect = 1e-35
Identities = 120/413 (29%), Positives = 193/413 (46%), Gaps = 45/413 (10%)
Query: 66 NLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLAN 125
N++++P +S + L EN++ + L +L+ L ++ N + TI GAF GL N
Sbjct: 111 NVKKMPQLLS-----VYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHN 165
Query: 126 LNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRL 185
L L L NRL I + F L L+ L + NPI I F + +LR L + + L
Sbjct: 166 LLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGI-NL 224
Query: 186 SYISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGLM 243
+ I + A GL NL ++ L ++P+ L ++ L LDL+ N ++ IR G F ++
Sbjct: 225 TEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNML 284
Query: 244 HLQKLWM--------IQS------------------QIQVIERNAFDNLQSLVEINLAHN 277
HL++L + I S ++ I NAF L L + L N
Sbjct: 285 HLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSN 344
Query: 278 NLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSW---WIKDMAPSNTACCARCNTPP 334
L+ L H L +L+ I +H NP C+C I W++ I+ M P + C PP
Sbjct: 345 ALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCV----DPP 400
Query: 335 NLKGRYIGELD-QNYFTCYAPVIVEP--PADLNVTEGMAAELKCRASTS-LTSVSWITPN 390
+G+ + ++ ++ P+I P++LNV G CRA+ + WITP+
Sbjct: 401 EFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPS 460
Query: 391 GTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNV 443
G + + V S+GTL+ VT ++ G+YTC+ +N VG S + V
Sbjct: 461 GQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKV 513
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 146 bits (368), Expect = 7e-35
Identities = 148/580 (25%), Positives = 232/580 (40%), Gaps = 117/580 (20%)
Query: 20 RALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCS-----------NQFSKVICVRKNLR 68
R L PLL+ +A V + CP C+C + + V C L
Sbjct: 2 RLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLT 61
Query: 69 EVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNT 128
VP + T+ L L N I + + +L +L L LS+N F+ L L +
Sbjct: 62 AVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLS 121
Query: 129 LELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGE------- 181
L L +N+LT + + +F L+ L+EL+L +N + I AF+ + +L RL L
Sbjct: 122 LHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAID 181
Query: 182 ------LKRLSYISEGA----------FEGLSNLRYLNLAMCNLREIPN----------- 214
L L + G F L+NLR L LA NLREI +
Sbjct: 182 SRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLES 241
Query: 215 ---------------LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQ----- 254
L + L LDL+ N L + PG F ++HL++L + +
Sbjct: 242 LSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSI 301
Query: 255 ---------------------IQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHL 293
+ I AF +L + + L +N L+ L L +L
Sbjct: 302 DKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNL 361
Query: 294 ERIHLHHNPWNCNCDILWLS---WWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFT 350
+ + LH NP C+C I W + ++ + P +T C PP+L+ + E+ T
Sbjct: 362 QEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCA----EPPDLQRLPVREVPFREMT 417
Query: 351 CYAPVIVEP---PADLNVTEGMAAELKCRA-STSLTSVSWITPNGTVMTHGAYKVRIAVL 406
+ ++ P P L V G + L CRA + + W+TP G +T R V
Sbjct: 418 DHCLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVY 477
Query: 407 SDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQ 466
+GTL VT ++ G+YTC+ N VG T + ++ V A ++P +
Sbjct: 478 PEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRA--------------LLQPGR 523
Query: 467 DEARTTDNNVGPTP----VVDWET--TNVTTSLTPQSTRS 500
DE + + V T ++ W T V+T+LT S S
Sbjct: 524 DEGQGLELRVQETHPYHILLSWVTPPNTVSTNLTWSSASS 563
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 146 bits (368), Expect = 7e-35
Identities = 148/580 (25%), Positives = 232/580 (40%), Gaps = 117/580 (20%)
Query: 20 RALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCS-----------NQFSKVICVRKNLR 68
R L PLL+ +A V + CP C+C + + V C L
Sbjct: 2 RLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLT 61
Query: 69 EVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNT 128
VP + T+ L L N I + + +L +L L LS+N F+ L L +
Sbjct: 62 AVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLS 121
Query: 129 LELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGE------- 181
L L +N+LT + + +F L+ L+EL+L +N + I AF+ + +L RL L
Sbjct: 122 LHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAID 181
Query: 182 ------LKRLSYISEGA----------FEGLSNLRYLNLAMCNLREIPN----------- 214
L L + G F L+NLR L LA NLREI +
Sbjct: 182 SRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLES 241
Query: 215 ---------------LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQ----- 254
L + L LDL+ N L + PG F ++HL++L + +
Sbjct: 242 LSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSI 301
Query: 255 ---------------------IQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHL 293
+ I AF +L + + L +N L+ L L +L
Sbjct: 302 DKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNL 361
Query: 294 ERIHLHHNPWNCNCDILWLS---WWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFT 350
+ + LH NP C+C I W + ++ + P +T C PP+L+ + E+ T
Sbjct: 362 QEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCA----EPPDLQRLPVREVPFREMT 417
Query: 351 CYAPVIVEP---PADLNVTEGMAAELKCRA-STSLTSVSWITPNGTVMTHGAYKVRIAVL 406
+ ++ P P L V G + L CRA + + W+TP G +T R V
Sbjct: 418 DHCLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVY 477
Query: 407 SDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQ 466
+GTL VT ++ G+YTC+ N VG T + ++ V A ++P +
Sbjct: 478 PEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRA--------------LLQPGR 523
Query: 467 DEARTTDNNVGPTP----VVDWET--TNVTTSLTPQSTRS 500
DE + + V T ++ W T V+T+LT S S
Sbjct: 524 DEGQGLELRVQETHPYHILLSWVTPPNTVSTNLTWSSASS 563
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 144 bits (362), Expect = 3e-34
Identities = 127/448 (28%), Positives = 205/448 (45%), Gaps = 73/448 (16%)
Query: 81 LNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIP 140
L+L+ N+I++I+ +F+ L LE+L+L RN+I + GAF GL+ ++ L L N L +
Sbjct: 216 LDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVN 275
Query: 141 NGAFVYLSKLKELWLRNNPIESIPS-------------YAFNRIPSLRRLDLGELKRL-- 185
+G+ L+ L +L L NN I I +FN + L L EL L
Sbjct: 276 SGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSV 335
Query: 186 --------SYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPG 237
S+I+EGAF+GL +LR L+ LD ++SG G
Sbjct: 336 LRLSHNSISHIAEGAFKGLRSLRVLD-----------------LDHNEISGTIEDT--SG 376
Query: 238 SFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIH 297
+F GL L KL + ++I+ + + AF L+ L +NL N + + D F + +L+ +H
Sbjct: 377 AFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELH 436
Query: 298 LHHNPWNCNCDILWLSWWI--KDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTC---Y 352
+ + + C+C + WL W+ + + TA CA P +LKG+ I + F C
Sbjct: 437 ISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAH---PESLKGQSIFSVPPESFVCDDFL 493
Query: 353 APVIVEPPADLNVTEGMAAELKCRASTSLTS---VSWITPNGTVMTHGAYKVRIAV-LSD 408
P I+ P G C A++S +S +W N V+T+ + + V D
Sbjct: 494 KPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDN-EVLTNADMENFVHVHAQD 552
Query: 409 G-------TLNFTNVTVQDTGMYTCMVSNSVGNT---TASATLNVTAA-TTTPFSYFSTV 457
G L+ VT G Y C+++N G+T A T+NV + T TP +
Sbjct: 553 GEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHD----I 608
Query: 458 TVETMEPSQDEARTTDNNVGPTPVVDWE 485
T+ T ++ E T + P P + W+
Sbjct: 609 TIRTTTMARLECAATGH---PNPQIAWQ 633
Score = 48.1 bits (113), Expect = 2e-05
Identities = 41/145 (28%), Positives = 64/145 (44%), Gaps = 11/145 (7%)
Query: 354 PVIVEPPADLNVTEGMAAELKCRASTSLT-SVSWITPNGTVMTHGAYKVRIAVLSDGTLN 412
P + P D+ + A L+C A+ ++W GT A + R+ V+ D +
Sbjct: 599 PSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFP-AARERRMHVMPDDDVF 657
Query: 413 F-TNVTVQDTGMYTCMVSNSVGNTTASATLNV--TAATTTPFSYFSTVTVETMEPSQDEA 469
F T+V + D G+Y+C NS G+ +A+ATL V T + P V E +
Sbjct: 658 FITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVP---LEDRVVSVGETVALQC 714
Query: 470 RTTDNNVGPTPVVDWETTNVTTSLT 494
+ T N P P + W + SLT
Sbjct: 715 KATGN---PPPRITWFKGDRPLSLT 736
Score = 35.8 bits (81), Expect = 0.12
Identities = 25/94 (26%), Positives = 44/94 (46%), Gaps = 4/94 (4%)
Query: 354 PVIVEPPADLNVTEGMAAELKCRASTSLTS-VSWITPNGTVMTHGAYKVRIAVLSDGTLN 412
P +V P D V+ G L+C+A+ + ++W + + + + + L
Sbjct: 693 PSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHL---TPDNQLLV 749
Query: 413 FTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAA 446
NV +D G YTC +SN++G A + L+V A
Sbjct: 750 VQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPA 783
>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
Length = 716
Score = 140 bits (352), Expect = 5e-33
Identities = 123/415 (29%), Positives = 189/415 (45%), Gaps = 44/415 (10%)
Query: 66 NLREVPDGISTNTRLLNLH--ENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGL 123
N++EV G++ T+L LH ENQI + + L +L+ L ++ N I TI AF GL
Sbjct: 109 NIKEV--GLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGL 166
Query: 124 ANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELK 183
NL L L N+L I + F L+ L + NP+ I F + +LR L L +
Sbjct: 167 KNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGM- 225
Query: 184 RLSYISEGAFEGLSNLRYLNLAMCNLREIPNLT--PLIKLDELDLSGNHLSAIRPGSFQG 241
L+ I A GL +L L+ L ++P L + L LDL+ N + I+ G F+
Sbjct: 226 YLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKN 285
Query: 242 LMHLQKLWM-IQSQIQVIERNAFDNLQSLVEIN-------------------------LA 275
++ L++L + ++ ++R A DNL L ++ L
Sbjct: 286 MLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLN 345
Query: 276 HNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLS---WWIKDMAPSNTACCARCNT 332
+N L + L +L I +H NP C+C I W++ I+ M P + C
Sbjct: 346 NNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCA----M 401
Query: 333 PPNLKGRYIGE-LDQNYFTCYAPVIVEP--PADLNVTEGMAAELKCRA-STSLTSVSWIT 388
PP KG + E L Q+ P+I P LNV G L CRA + + W+T
Sbjct: 402 PPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVT 461
Query: 389 PNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNV 443
P G +T + + S+GTL +N+ ++D+G YTC+ N G T AT+ V
Sbjct: 462 PIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKV 516
>gi|55741571 leucine rich repeat and fibronectin type III domain
containing 2 [Homo sapiens]
Length = 789
Score = 137 bits (346), Expect = 2e-32
Identities = 120/426 (28%), Positives = 179/426 (42%), Gaps = 60/426 (14%)
Query: 47 CPSVCSCSNQFSKV--ICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEI 104
CP C C N + +C K L VP I T L L N I I F ++ L
Sbjct: 21 CPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLVD 80
Query: 105 LQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIP 164
L LSRN I I+ +F L +L +L L NRL ++ L L+ L + NN + I
Sbjct: 81 LTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIA 140
Query: 165 SYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIP--NLTPLIKLD 222
AF + L L L+L+ NL +P ++ ++ L
Sbjct: 141 DEAFE------------------------DFLLTLEDLDLSYNNLHGLPWDSVRRMVNLH 176
Query: 223 ELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLL 282
+L L N L I G+F L L +L + +++Q + + A + + L
Sbjct: 177 QLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPI----------FARSQASAL 226
Query: 283 PHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIG 342
F P NP +CNC++LWL +D C +P LKGRY
Sbjct: 227 TATPFAPPLSFS---FGGNPLHCNCELLWLRRLERD------DDLETCGSPGGLKGRYFW 277
Query: 343 ELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRA-STSLTSVSWITPNGTVMTHGAYKV 401
+ + F C P+I + L V EG AA LKC+A + W+ P+ ++ + +
Sbjct: 278 HVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSS--- 334
Query: 402 RIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATL---------NVTAATTTPFS 452
R AV +GTL+ T QD+G +TC+ +N+ G TA + N T+ T P S
Sbjct: 335 RTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPHLSNSTSRTAPPKS 394
Query: 453 YFSTVT 458
S +T
Sbjct: 395 RLSDIT 400
>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
sapiens]
Length = 660
Score = 134 bits (338), Expect = 2e-31
Identities = 106/353 (30%), Positives = 168/353 (47%), Gaps = 44/353 (12%)
Query: 31 LALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQI-- 88
L + L + + + + CPSVC C F V C ++L VP GI +L LH NQI
Sbjct: 20 LIISLGLYSQVSKLLACPSVCRCDRNF--VYCNERSLTSVPLGIPEGVTVLYLHNNQINN 77
Query: 89 -----QIIKVNSFKHL---------------RHLEILQLSRNHIRTIEIGAFNGLANLNT 128
++ V S + +++ +L L N+I+TI A L L
Sbjct: 78 AGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEE 137
Query: 129 LELFDNRLTTI--PNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELK--- 183
L L DN ++T+ +GAF LK L+L N + S+P +P +DL EL+
Sbjct: 138 LHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPV----GLP----VDLQELRVDE 189
Query: 184 -RLSYISEGAFEGLSNLRYL----NLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGS 238
R++ IS+ AF+ L++L L NL + L KL E + N LS P
Sbjct: 190 NRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSH-PPPD 248
Query: 239 FQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHL 298
G HL +L++ +QI I AF NL+ L +++++N L +L +F L +L+++
Sbjct: 249 LPGT-HLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTA 307
Query: 299 HHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTC 351
+NPW C+C I W++ W+K + S C P ++G + EL+ N +C
Sbjct: 308 RNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSC 360
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 134 bits (336), Expect = 3e-31
Identities = 89/266 (33%), Positives = 133/266 (50%), Gaps = 7/266 (2%)
Query: 77 NTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRL 136
N R L L NQ+ + F L ++ L L RN + + G F G+ L L+L +N +
Sbjct: 133 NLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNI 192
Query: 137 TTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGL 196
I F +L L L+L +N + +PS AF + SLRRL L + I AF+GL
Sbjct: 193 LRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSH-NPIEAIQPFAFKGL 251
Query: 197 SNLRYLNLAMCNLREI--PNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQ 254
+NL YL L +R + + + L L LS N L + +F L +L L + +++
Sbjct: 252 ANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNR 311
Query: 255 IQVIERNAFDNL-QSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLS 313
I I+ + F+N+ SL +NL+ NNLT L + PL L + + NPW CNC +L L
Sbjct: 312 IISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLR 371
Query: 314 WWIKDMAPSNTACCARCNTPPNLKGR 339
W +A S C PP+++GR
Sbjct: 372 DW---LASSAITLNIYCQNPPSMRGR 394
>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
sapiens]
Length = 674
Score = 134 bits (336), Expect = 3e-31
Identities = 117/408 (28%), Positives = 182/408 (44%), Gaps = 54/408 (13%)
Query: 41 LVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGI-------------------------S 75
++ + TCPSVC C N F + C + L +P I
Sbjct: 48 VIDSTTCPSVCRCDNGF--IYCNDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTK 105
Query: 76 TNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNR 135
N +++ L+EN + +N + LR L L N++RTI + + L L L DN
Sbjct: 106 VNVQVIYLYENDLDEFPINLPRSLRELH---LQDNNVRTIARDSLARIPLLEKLHLDDNS 162
Query: 136 LTT--IPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAF 193
++T I AF +LK L+L N + SIPS + + LR D R+S I AF
Sbjct: 163 VSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDD----NRISTIPLHAF 218
Query: 194 EGLSNLRYLNL---AMCNLREIPN-LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLW 249
+GL++LR L L + N R + + L L EL L N L+A P HLQKL+
Sbjct: 219 KGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAA--PPLNLPSAHLQKLY 276
Query: 250 MIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDI 309
+ + I I N ++ L ++L++NNLT LP LF L +L ++ L +NPW C C++
Sbjct: 277 LQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNL 336
Query: 310 LWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGM 369
+WL W+K A C P ++G I ++ C+ +G
Sbjct: 337 MWLRDWVKARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDECFE----------TGPQGG 386
Query: 370 AAELKCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVT 417
A + +T+ S TP G++ T A + + L D +++ T
Sbjct: 387 VANAAAK-TTASNHASATTPQGSLFTLKAKRPGLR-LPDSNIDYPMAT 432
>gi|149773484 leucine rich repeat and fibronectin type III domain
containing 1 [Homo sapiens]
Length = 771
Score = 133 bits (334), Expect = 6e-31
Identities = 126/442 (28%), Positives = 186/442 (42%), Gaps = 83/442 (18%)
Query: 15 GPRFNRALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKV--ICVRKNLREVPD 72
GP F+ AL P L L LL+ AG R Q CP C C N + +C + L VP
Sbjct: 4 GP-FSSALLSPPPAALPFL-LLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPP 61
Query: 73 GISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELF 132
I R +E L L
Sbjct: 62 AIDR------------------------------------RVVE------------LRLT 73
Query: 133 DNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGA 192
DN + + F ++ L L L N I + + AF + +LR L L + RL+ +
Sbjct: 74 DNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHL-DSNRLAEVRGDQ 132
Query: 193 FEGLSNLRYLNLAMCNLREIPNLTP---LIKLDELDLSGNHLSAIRPGSFQGLMHLQKLW 249
GL NLR+L L +R + + L +++LDLS N+L A+ + +++L L
Sbjct: 133 LRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLT 192
Query: 250 MIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHD-LF-----------TPLHHLERIH 297
+ + I I F L LV +++ N L LP D LF TPL +
Sbjct: 193 LDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPL----TVS 248
Query: 298 LHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIV 357
NP +CNC++LWL ++ + CA TP +L RY + + F C P+I
Sbjct: 249 FGGNPLHCNCELLWLRRLTRE---DDLETCA---TPEHLTDRYFWSIPEEEFLCEPPLIT 302
Query: 358 EPPADLN-VTEGMAAELKCRA-STSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTN 415
V EG A L+CRA V W+ P+G ++ + + R V DGTL+ T
Sbjct: 303 RQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSS---RTRVRGDGTLDVTI 359
Query: 416 VTVQDTGMYTCMVSNSVGNTTA 437
T++D+G +TC+ SN+ G TA
Sbjct: 360 TTLRDSGTFTCIASNAAGEATA 381
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 132 bits (333), Expect = 7e-31
Identities = 127/429 (29%), Positives = 197/429 (45%), Gaps = 32/429 (7%)
Query: 79 RLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTT 138
+ L L N+I+I++ +F+ L L L++ RN I ++ GAF GL N+ LEL N LT
Sbjct: 218 QFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTR 277
Query: 139 IPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSN 198
+ G L L++L++ N IE I A+ L LDL +L+ + E AF GLS
Sbjct: 278 VNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDL-SYNQLTRLDESAFVGLSL 336
Query: 199 LRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLS-AIRPGS--FQGLMHLQKLWMIQS 253
L LNL + I + L L LDL N +S AI S F GL L KL + +
Sbjct: 337 LERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGN 396
Query: 254 QIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLS 313
QI+ I + AF L+SL ++L +N + + + F+ HL+ + L+ + C+C + WL
Sbjct: 397 QIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQT-HLKELILNTSSLLCDCHLKWLL 455
Query: 314 WWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTC---YAPVIVEPPADLNVTEGMA 370
W+ D ++ + C P L G+ I +D F C P I P + GM
Sbjct: 456 QWLVDNNFQHSVNVS-CAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMN 514
Query: 371 AELKCRA-STSLTSVSWITPNGTVMTHGA---------YKVRIAVLSDGTLNFTNVTVQD 420
L C A S+S + +S + + + + + A+ L+ NV D
Sbjct: 515 VTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTD 574
Query: 421 TGMYTCMVSNSVG-NTTASATLNVTAATT---TPFSYFSTVTVETMEPSQDEARTTDNNV 476
G Y C+V+N G N + A L V + TP +T+ T ++ E +
Sbjct: 575 EGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMD----LTIRTGAMARLECAAEGH-- 628
Query: 477 GPTPVVDWE 485
P P + W+
Sbjct: 629 -PAPQISWQ 636
Score = 97.8 bits (242), Expect = 3e-20
Identities = 74/222 (33%), Positives = 118/222 (53%), Gaps = 26/222 (11%)
Query: 81 LNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGL-ANLNTLELFDNRLTTI 139
L+L N I IK +SF ++ L+ L LS N I T+E G F+ L ++L ++L NR++ I
Sbjct: 149 LDLSSNIISEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMI 207
Query: 140 PNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNL 199
P F L L+ L L+ N I+ + F + SLR L + + +S + +GAF GL+N
Sbjct: 208 PPKIF-KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKM-QRNGISKLKDGAFFGLNN- 264
Query: 200 RYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIE 259
++EL+L N+L+ + G GL LQ+L++ Q+ I+ I
Sbjct: 265 ---------------------MEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERIS 303
Query: 260 RNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
+A++ Q L E++L++N LT L F L LER++L N
Sbjct: 304 PDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDN 345
Score = 51.6 bits (122), Expect = 2e-06
Identities = 34/132 (25%), Positives = 56/132 (42%), Gaps = 5/132 (3%)
Query: 354 PVIVEPPADLNVTEGMAAELKCRASTS-LTSVSWITPNGTVMTHGAYKVRIAVLSDGTLN 412
P ++ P DL + G A L+C A +SW GT + + D
Sbjct: 602 PSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFF 661
Query: 413 FTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTT 472
NV ++D G+Y+CM N+ G +A+A+L V TP S+ + +T+ +
Sbjct: 662 IANVKIEDMGIYSCMAQNTAGGLSANASLTV---LETP-SFIRPLEDKTVTRGETAVLQC 717
Query: 473 DNNVGPTPVVDW 484
P P ++W
Sbjct: 718 IAGGSPAPRLNW 729
Score = 48.9 bits (115), Expect = 1e-05
Identities = 41/129 (31%), Positives = 65/129 (50%), Gaps = 9/129 (6%)
Query: 176 RLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREI--PNLTPLIKLDELDLSGNHLSA 233
+++ EL + Y E SN+ L+L + EI L L+ LDLS N +S
Sbjct: 103 KMNYNELTEIPYFGEPT----SNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISE 158
Query: 234 IRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNL-QSLVEINLAHNNLTLLPHDLFTPLHH 292
I+ SF M L+ L + ++I +E FDNL SL+ + L N ++++P +F L H
Sbjct: 159 IKTSSFPR-MQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIF-KLPH 216
Query: 293 LERIHLHHN 301
L+ + L N
Sbjct: 217 LQFLELKRN 225
Score = 40.8 bits (94), Expect = 0.004
Identities = 26/94 (27%), Positives = 44/94 (46%), Gaps = 4/94 (4%)
Query: 354 PVIVEPPADLNVTEGMAAELKCRASTS-LTSVSWITPNGTVMTHGAYKVRIAVLSDGTLN 412
P + P D VT G A L+C A S ++W +G ++ + A + L
Sbjct: 696 PSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAA---NQLLI 752
Query: 413 FTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAA 446
+ ++D G YTC++SN++G LNV ++
Sbjct: 753 IVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISS 786
>gi|88702793 slit-like 2 [Homo sapiens]
Length = 673
Score = 132 bits (332), Expect = 1e-30
Identities = 116/373 (31%), Positives = 169/373 (45%), Gaps = 49/373 (13%)
Query: 29 VLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQI 88
+LL L LL+ G Q CPS C CS Q V C + VP + +T L + EN I
Sbjct: 7 LLLPLLLLLALG-PGVQGCPSGCQCS-QPQTVFCTARQGTTVPRDVPPDTVGLYVFENGI 64
Query: 89 QIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLS 148
++ SF L L++L LS+N I ++ G F LANL+ L+L NRL I N F L
Sbjct: 65 TMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLR 124
Query: 149 KLKELWLRNNPIESIPSYAFN---------------------RIPSLRRLDLGELKRLSY 187
+L+ L+L N I I AF+ R+P L LDL L+
Sbjct: 125 RLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNSLLAL 184
Query: 188 ISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGLMHL 245
E +N+ L LA L+++ + L L +LD+S N L + P +GL L
Sbjct: 185 --EPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERV-PPVIRGLRGL 241
Query: 246 QKLWMI-QSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWN 304
+L + ++I + L +L E+++++ +L LP DL L + NP+N
Sbjct: 242 TRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFN 301
Query: 305 CNCDILWLSWWIKD-----MAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYA------ 353
C C + W W+++ +P T RC+ PP GR + ELD F C A
Sbjct: 302 CVCPLSWFGPWVRESHVTLASPEET----RCHFPPKNAGRLLLELDYADFGCPATTTTAT 357
Query: 354 -----PVIVEPPA 361
PV+ EP A
Sbjct: 358 VPTTRPVVREPTA 370
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 131 bits (329), Expect = 2e-30
Identities = 102/340 (30%), Positives = 166/340 (48%), Gaps = 35/340 (10%)
Query: 32 ALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNT---RLLNLHENQI 88
+L+ L+++ Q P+ S + ++ +L +PDG + LNL +N +
Sbjct: 132 SLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSL 191
Query: 89 QIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLS 148
I F+HL +L++L+L N + I +G F+GL NL L L N++ + G F
Sbjct: 192 THISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNH 251
Query: 149 KLKELWLRNNPIESIPSYAFNRIPSLRRLDL--GELKRLSYISEGAFEGLSNLRYLNLAM 206
L+ L+L NN I +P F ++P L RL L LK LS G F + NLR L L
Sbjct: 252 NLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSL---GIFGPMPNLRELWLYD 308
Query: 207 CNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFD 264
++ +P+ + L +L L LS N +S I PG+F GL L++L + + +Q ++ N F
Sbjct: 309 NHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFR 368
Query: 265 NLQSLVEINLAHNNLTLLPHDLFTPLH---------------------HLER---IHLHH 300
L +L I+L +N L LP ++F ++ HL + + L+
Sbjct: 369 MLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYD 428
Query: 301 NPWNCNCDILWL-SWWIKDMAPSNTACCARCNTPPNLKGR 339
NPW C+ DIL L +W + + T C +P N++G+
Sbjct: 429 NPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQ 468
Score = 122 bits (305), Expect = 1e-27
Identities = 88/281 (31%), Positives = 135/281 (48%), Gaps = 28/281 (9%)
Query: 47 CPSVCSCSNQFSKVICVRKNLREVPDGISTNT---RLLNLH------------------- 84
CPS C+CS S+V C + VP + N ++LN H
Sbjct: 31 CPSECTCSRA-SQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALR 89
Query: 85 --ENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNG 142
+N++ I +F++L L L L+ N ++ + IG F GL +L +L L N+L I
Sbjct: 90 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 149
Query: 143 AFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYL 202
F S LKEL L N +E IP AF+ + L +L+LG+ L++IS F+ L NL+ L
Sbjct: 150 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGK-NSLTHISPRVFQHLGNLQVL 208
Query: 203 NLAMCNLREIP--NLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIER 260
L L +IP L+ L EL L N + + PG F +LQ+L++ + I +
Sbjct: 209 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPP 268
Query: 261 NAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
+ F L L + L N+L L +F P+ +L + L+ N
Sbjct: 269 SIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 309
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 131 bits (329), Expect = 2e-30
Identities = 102/340 (30%), Positives = 166/340 (48%), Gaps = 35/340 (10%)
Query: 32 ALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNT---RLLNLHENQI 88
+L+ L+++ Q P+ S + ++ +L +PDG + LNL +N +
Sbjct: 126 SLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSL 185
Query: 89 QIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLS 148
I F+HL +L++L+L N + I +G F+GL NL L L N++ + G F
Sbjct: 186 THISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNH 245
Query: 149 KLKELWLRNNPIESIPSYAFNRIPSLRRLDL--GELKRLSYISEGAFEGLSNLRYLNLAM 206
L+ L+L NN I +P F ++P L RL L LK LS G F + NLR L L
Sbjct: 246 NLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSL---GIFGPMPNLRELWLYD 302
Query: 207 CNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFD 264
++ +P+ + L +L L LS N +S I PG+F GL L++L + + +Q ++ N F
Sbjct: 303 NHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFR 362
Query: 265 NLQSLVEINLAHNNLTLLPHDLFTPLH---------------------HLER---IHLHH 300
L +L I+L +N L LP ++F ++ HL + + L+
Sbjct: 363 MLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYD 422
Query: 301 NPWNCNCDILWL-SWWIKDMAPSNTACCARCNTPPNLKGR 339
NPW C+ DIL L +W + + T C +P N++G+
Sbjct: 423 NPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQ 462
Score = 122 bits (305), Expect = 1e-27
Identities = 88/281 (31%), Positives = 135/281 (48%), Gaps = 28/281 (9%)
Query: 47 CPSVCSCSNQFSKVICVRKNLREVPDGISTNT---RLLNLH------------------- 84
CPS C+CS S+V C + VP + N ++LN H
Sbjct: 25 CPSECTCSRA-SQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALR 83
Query: 85 --ENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNG 142
+N++ I +F++L L L L+ N ++ + IG F GL +L +L L N+L I
Sbjct: 84 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143
Query: 143 AFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYL 202
F S LKEL L N +E IP AF+ + L +L+LG+ L++IS F+ L NL+ L
Sbjct: 144 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGK-NSLTHISPRVFQHLGNLQVL 202
Query: 203 NLAMCNLREIP--NLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIER 260
L L +IP L+ L EL L N + + PG F +LQ+L++ + I +
Sbjct: 203 RLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPP 262
Query: 261 NAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
+ F L L + L N+L L +F P+ +L + L+ N
Sbjct: 263 SIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 303
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 130 bits (328), Expect = 3e-30
Identities = 98/339 (28%), Positives = 146/339 (43%), Gaps = 33/339 (9%)
Query: 155 LRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPN 214
LR N I IP AF ++ +L L L + IS AFEGL NL YL L
Sbjct: 57 LRFNRIREIPGSAFKKLKNLNTLLLNN-NHIRKISRNAFEGLENLLYLYLYK-------- 107
Query: 215 LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINL 274
N + A+ +F+GL+ L+ L++ +Q+++++ F +L L + L
Sbjct: 108 --------------NEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFL 153
Query: 275 AHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAP-SNTACCARCNTP 333
+N L+ +P F+ L L+R+ L N C+CD++WL ++ A +T A C P
Sbjct: 154 HNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYP 213
Query: 334 PNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRA-STSLTSVSWITPNGT 392
L GR + + F C +P I P D+ V G CRA + WI N +
Sbjct: 214 RRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHS 273
Query: 393 VMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNT-TASATLNVTAATTTPF 451
+ R+ V DGTL N D G+Y CM NS G T SA L ++ P
Sbjct: 274 LDLED--DTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPS 331
Query: 452 SYFSTVTVETMEPSQD--EARTTDNNVGPTPVVDWETTN 488
E + + E T + P P++ W N
Sbjct: 332 FVIQPQDTEVLIGTSTTLECMATGH---PHPLITWTRDN 367
Score = 99.8 bits (247), Expect = 7e-21
Identities = 123/488 (25%), Positives = 188/488 (38%), Gaps = 63/488 (12%)
Query: 47 CPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQ 106
CPS C C S V C+ L +P + T +L+L N+I+ I ++FK L++L L
Sbjct: 24 CPSRCLCFK--STVRCMHLMLDHIPQ-VPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLL 80
Query: 107 LSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSY 166
L+ NHIR I AF GL NL L L+ N + + F L L+ L++ N +E +
Sbjct: 81 LNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPE 140
Query: 167 AFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDL 226
F + L RL L +LS I G+F L +L+ L L L +L L +L +
Sbjct: 141 TFGDLLRLERLFLHN-NKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFA 199
Query: 227 SGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDL 286
H A + +H + + + ++ E N +T P D+
Sbjct: 200 QHGHTQAAATCEYPRRLHGRAVASV----------------TVEEFNCQSPRITFEPQDV 243
Query: 287 FTPLHHLERIHLHHNPWNCNCDILWL----SWWIKDMAPSNTACCARCNTPPNLKGRYIG 342
P + N +I+W+ S ++D N L R
Sbjct: 244 EVPSGNTVYFTCRAE-GNPKPEIIWIHNNHSLDLEDDTRLNVF------DDGTLMIRNTR 296
Query: 343 ELDQNYFTCYA----------------------PVIVEPPADLNVTEGMAAELKCRAS-T 379
E DQ + C A P V P D V G + L+C A+
Sbjct: 297 ESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGH 356
Query: 380 SLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASA 439
++W NG + + V + L N+T +D G +TC +NS G A+A
Sbjct: 357 PHPLITWTRDNGLELDGSRH-----VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAA 411
Query: 440 TLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVVDWETTNVTTSLTPQSTR 499
+ V A + V +E E + + D N P PV+ W T + Q T
Sbjct: 412 NIIVQAPPQFTVTPKDQVVLE--EHAVEWLCEADGN--PPPVIVWTKTGGQLPVEGQHTV 467
Query: 500 STEKTFTI 507
+ T I
Sbjct: 468 LSSGTLRI 475
Score = 44.7 bits (104), Expect = 3e-04
Identities = 46/186 (24%), Positives = 66/186 (35%), Gaps = 25/186 (13%)
Query: 341 IGELDQNYFTCYAP-----------VIVEPPADLNVT-------EGMAAELKCRASTSLT 382
I + D FTC+A +IV+ P VT E A E C A +
Sbjct: 388 ITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPP 447
Query: 383 SVS-WITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATL 441
V W G + G + VLS GTL D G Y C +S+G S L
Sbjct: 448 PVIVWTKTGGQLPVEGQH----TVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQL 503
Query: 442 NVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVVDWETTNVTTSLTPQSTRST 501
V F+ T ++E ++ + P P++ W V + + +
Sbjct: 504 TVKPKALAVFTQLPQDT--SVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDD 561
Query: 502 EKTFTI 507
E T TI
Sbjct: 562 EGTLTI 567
Score = 35.8 bits (81), Expect = 0.12
Identities = 24/91 (26%), Positives = 34/91 (37%), Gaps = 3/91 (3%)
Query: 355 VIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFT 414
V + P D +V G + C A + G +T + V +GTL
Sbjct: 512 VFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESG---KFHVDDEGTLTIY 568
Query: 415 NVTVQDTGMYTCMVSNSVGNTTASATLNVTA 445
+ D G Y C+ NS G + L VTA
Sbjct: 569 DAGFPDQGRYECVARNSFGLAVTNMFLTVTA 599
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 129 bits (325), Expect = 6e-30
Identities = 88/314 (28%), Positives = 147/314 (46%), Gaps = 30/314 (9%)
Query: 67 LREVPDGISTNTRLL---NLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGL 123
L +P+G+ + L +L NQ+Q + F+ L HL+ L L++N + + F+ L
Sbjct: 133 LEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192
Query: 124 ANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELK 183
+L TL+L +N L+ +P G F L L+EL+L +N I +P F+++ L RL L +
Sbjct: 193 TSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWL-QRN 251
Query: 184 RLSYISEGAFEGLSNLRYLNLAMCNLREIP--------------------------NLTP 217
++++ F L NL +L+L LR +P
Sbjct: 252 AITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAH 311
Query: 218 LIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHN 277
L L L LS N ++ + G F+ L L KL++ + + + F NL L ++L+ N
Sbjct: 312 LSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKN 371
Query: 278 NLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLK 337
LT LP +F ++L + LH NPW C+C + +L W++ C P LK
Sbjct: 372 QLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLK 431
Query: 338 GRYIGELDQNYFTC 351
G+ + L++ C
Sbjct: 432 GQVVPALNEKQLVC 445
Score = 60.1 bits (144), Expect = 6e-09
Identities = 50/171 (29%), Positives = 76/171 (44%), Gaps = 6/171 (3%)
Query: 133 DNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGA 192
D L T+P Y K + ++ + AF P+L ++ + L A
Sbjct: 37 DEELATVPLDIPPYT---KNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQ-LCQFRPDA 92
Query: 193 FEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWM 250
F GL L L + + + + L L +L L+ N L A+ G FQ L L+ L +
Sbjct: 93 FGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHL 152
Query: 251 IQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
+Q+Q + R F L L +NLA N L LP +LF PL L+ + L +N
Sbjct: 153 QGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNN 203
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 129 bits (325), Expect = 6e-30
Identities = 106/322 (32%), Positives = 145/322 (45%), Gaps = 32/322 (9%)
Query: 47 CPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQ 106
CP C C + C L+ VP G ++T+LL+L N + +F L HL L
Sbjct: 396 CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLH 455
Query: 107 LSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSY 166
L I +E GA GL L L L DN+L + A +L L+L N +P
Sbjct: 456 LQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGA 515
Query: 167 AFNRIPSLRRL-------------DLGELK----------RLSYISEGAFEGLSNLRYLN 203
A +PSL L DLG + R++ +S GA L L+
Sbjct: 516 ALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLH 575
Query: 204 LAMCNLREIPN--LTPLIKLDELDLSGNHLSAIRPGSFQGL-MHLQKLWMIQSQIQVIER 260
L LRE+P L L L EL LSGN L A+R G+FQ + LQ L++ S ++ I
Sbjct: 576 LDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICP 635
Query: 261 NAFDNL-QSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDM 319
AF L L ++L N L LP L LE I L NP++C+C +L L W+ +
Sbjct: 636 GAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGL 693
Query: 320 APSNTACCARCNTPPNLKGRYI 341
N A C TPPN +G+ +
Sbjct: 694 ---NLRVGATCATPPNARGQRV 712
Score = 123 bits (308), Expect = 6e-28
Identities = 111/361 (30%), Positives = 158/361 (43%), Gaps = 40/361 (11%)
Query: 13 MIGPRFNRALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPD 72
M GPR + + PL++ LL L LL A AQ CP C C N V C +NL EVPD
Sbjct: 1 MEGPRSSTHV--PLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPD 58
Query: 73 GISTNTRLLNLHENQIQIIKVNSFK---HLRHLEI---------------------LQLS 108
I T+ L+L N +++I +F+ HL HL++ L L+
Sbjct: 59 AIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLA 118
Query: 109 RNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAF 168
NH+R + A +GL +L LEL N L + G F L L L L +N + +P+ AF
Sbjct: 119 SNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAF 178
Query: 169 NRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPN--LTPLIKLDELDL 226
+ +R L L LS ++ A GL LR L+L L+ +P L+ L L+L
Sbjct: 179 QGLLRVRWLRLSH-NALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLEL 237
Query: 227 SGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDL 286
N L+ L L++L + +Q + AF + L ++L N L LP
Sbjct: 238 GHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP--- 294
Query: 287 FTPLH---HLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGE 343
PL L R+ L NP C C L W +A + C P L+G +
Sbjct: 295 --PLQGPGQLRRLRLQGNPLWCGCQARPLLEW---LARARVRSDGACQGPRRLRGEALDA 349
Query: 344 L 344
L
Sbjct: 350 L 350
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 129 bits (324), Expect = 8e-30
Identities = 112/402 (27%), Positives = 171/402 (42%), Gaps = 51/402 (12%)
Query: 47 CPSVCSCSNQFS--KVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEI 104
CP C C Q V+C L VP + L L +N I ++ ++ L
Sbjct: 28 CPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRRDLANMTGLLH 87
Query: 105 LQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIP 164
L LSRN IR + GAF L L L L NRLT++ G L L+ L L NN + ++
Sbjct: 88 LSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALA 147
Query: 165 SYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIP--NLTPLIKLD 222
+ A + D E L L+L+ NL ++P L L ++
Sbjct: 148 AGALD--------DCAE----------------TLEDLDLSYNNLEQLPWEALGRLGNVN 183
Query: 223 ELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLL 282
L L N L+++ G+F L L +L M +++ I + + L LL
Sbjct: 184 TLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPL------------FSRLPLL 231
Query: 283 PHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIG 342
+P L + NP +CNC+++WL ++ + CA +PP L GRY
Sbjct: 232 ARPRGSPASALV-LAFGGNPLHCNCELVWLRRLARE---DDLEACA---SPPALGGRYFW 284
Query: 343 ELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRA-STSLTSVSWITPNGTVMTHGAYKV 401
+ + F C PV+ L V G A L+CRA V W++P G ++ + +
Sbjct: 285 AVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQGRLLGNSS--- 341
Query: 402 RIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNV 443
R +GTL D G++TC+ +N+ G TA+ L V
Sbjct: 342 RARAFPNGTLELLVTEPGDGGIFTCIAANAAGEATAAVELTV 383
>gi|38202222 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 128 bits (322), Expect = 1e-29
Identities = 106/355 (29%), Positives = 169/355 (47%), Gaps = 38/355 (10%)
Query: 26 LLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHE 85
L+ + L L V V A++CPSVC C F + C + L +P GI + L L
Sbjct: 10 LIGTKIGLFLQVAPLSVMAKSCPSVCRCDAGF--IYCNDRFLTSIPTGIPEDATTLYLQN 67
Query: 86 NQIQ----------IIKV-------NSFKHL-----RHLEILQLSRNHIRTIEIGAFNGL 123
NQI ++KV NS ++++ L L N+IRTI + + +
Sbjct: 68 NQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKI 127
Query: 124 ANLNTLELFDNRLT--TIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGE 181
L L L DN ++ +I GAF + L+ L+L N + +IP I LR D
Sbjct: 128 PYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDD--- 184
Query: 182 LKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTP-----LIKLDELDLSGNHLSAIRP 236
R+S IS + +GL++L+ L L NL L L+ L EL L N L+A P
Sbjct: 185 -NRISTISSPSLQGLTSLKRLVLDG-NLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA-P 241
Query: 237 GSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERI 296
+ G +L+KL++ + I + NAF L+ L +++++NNL+ LP +F L ++ ++
Sbjct: 242 VNLPGT-NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQL 300
Query: 297 HLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTC 351
L +NPW C C + W+ W++ + C P ++G I +L+ F C
Sbjct: 301 ILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDC 355
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,671,359
Number of Sequences: 37866
Number of extensions: 1042499
Number of successful extensions: 8335
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 381
Number of HSP's successfully gapped in prelim test: 227
Number of HSP's that attempted gapping in prelim test: 3282
Number of HSP's gapped (non-prelim): 2746
length of query: 640
length of database: 18,247,518
effective HSP length: 109
effective length of query: 531
effective length of database: 14,120,124
effective search space: 7497785844
effective search space used: 7497785844
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.