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Search of human proteins with 50726968
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50726968 microfibrillar-associated protein 1 [Homo sapiens]
(439 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50726968 microfibrillar-associated protein 1 [Homo sapiens] 863 0.0
gi|148746195 trichohyalin [Homo sapiens] 85 1e-16
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 83 4e-16
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 83 6e-16
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 82 7e-16
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 81 2e-15
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 81 2e-15
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 80 3e-15
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 80 4e-15
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 79 6e-15
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 78 1e-14
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 77 2e-14
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 75 2e-13
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 75 2e-13
gi|148839339 nexilin (F actin binding protein) [Homo sapiens] 74 2e-13
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 73 4e-13
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 73 4e-13
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 73 4e-13
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 73 4e-13
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 73 4e-13
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 73 4e-13
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 73 4e-13
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 73 4e-13
gi|48255879 troponin T type 2, cardiac isoform 2 [Homo sapiens] 73 6e-13
gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens] 72 1e-12
gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens] 71 2e-12
gi|221219020 NYD-SP11 protein [Homo sapiens] 71 2e-12
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 70 4e-12
gi|48255881 troponin T type 2, cardiac isoform 3 [Homo sapiens] 70 5e-12
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 69 8e-12
>gi|50726968 microfibrillar-associated protein 1 [Homo sapiens]
Length = 439
Score = 863 bits (2229), Expect = 0.0
Identities = 439/439 (100%), Positives = 439/439 (100%)
Query: 1 MSVPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEF 60
MSVPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEF
Sbjct: 1 MSVPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEF 60
Query: 61 QFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEV 120
QFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEV
Sbjct: 61 QFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEV 120
Query: 121 EGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESE 180
EGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESE
Sbjct: 121 EGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESE 180
Query: 181 SESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYT 240
SESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYT
Sbjct: 181 SESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYT 240
Query: 241 LKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKE 300
LKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKE
Sbjct: 241 LKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKE 300
Query: 301 KAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDF 360
KAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDF
Sbjct: 301 KAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDF 360
Query: 361 SAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQK 420
SAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQK
Sbjct: 361 SAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNTKFFKQK 420
Query: 421 AAGVRDVFERPSAKKRKTT 439
AAGVRDVFERPSAKKRKTT
Sbjct: 421 AAGVRDVFERPSAKKRKTT 439
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 85.1 bits (209), Expect = 1e-16
Identities = 81/327 (24%), Positives = 159/327 (48%), Gaps = 36/327 (11%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQ----- 76
++ E+ E+ E+ + +R +R Y E +E+E+ ++ K + E E Q
Sbjct: 906 LQEEEEELQREEREKRRRQEQER-QYREEEQLQQEEEQLLREEREKRRRQERERQYRKDK 964
Query: 77 ------EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRME-- 128
E+ +P RR Q R + EE + E +++ E + W +
Sbjct: 965 KLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE---EEQLLREEREKRRRQEWERQYR 1021
Query: 129 REDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESE--SEYE 186
++D ++EEE++ EE E+RR R+R Q R+ EE++ E+E GEE E+ E E
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERER-QYREEEELQQ---EEEQLLGEERETRRRQELE 1077
Query: 187 EYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRM----AEERRKYTLK 242
E+E++ + + + ++ QERE + +++EL+QE +++ E+RR+ L+
Sbjct: 1078 RQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELE 1137
Query: 243 ---IVEEETKKELEE------NKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDRED 293
EEE ++E E+ KR L+ ++E ++E E E ++ +++RE
Sbjct: 1138 RQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER 1197
Query: 294 REALEKEKAEIERMRNLTEEERRAELR 320
+ E+E +R + +E++R++L+
Sbjct: 1198 QYREEEELQRQKRKQRYRDEDQRSDLK 1224
Score = 79.7 bits (195), Expect = 5e-15
Identities = 70/283 (24%), Positives = 136/283 (48%), Gaps = 23/283 (8%)
Query: 55 EEDEEFQFIKKAKEQEAEPEEQ---EEDSSSDPRLRRLQNRISEDV---EERLARHRKI- 107
E++EE + + +EQ+ E+Q E+ + +LRR Q E E++L R +++
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 108 -VEPEVVGESDSEVEGDAWRMEREDSSEEE----EEEIDDEEIERRRGMMRQRAQERKNE 162
+ E E E E R++RE + EEE + E ERR+ +++ +E + E
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486
Query: 163 EMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQ 222
+E E+ E E + E+ E ++ + + ++++ R Q R + ++
Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERR 546
Query: 223 KEL--EQEAKRMAEERRKYTLKIVEEETKKEL---EENKRSLAALDALNTDDENDEEEYE 277
++L +E KR+ +ERR+ LK +EE + +L EE +R E +E +
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQ------QRLKREQEERLEQ 600
Query: 278 AWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELR 320
K E++R++++ + L++E+ E ER + L + E + E R
Sbjct: 601 RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR 643
Score = 79.0 bits (193), Expect = 8e-15
Identities = 68/258 (26%), Positives = 128/258 (49%), Gaps = 25/258 (9%)
Query: 75 EQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSE 134
++E+ + D + LQ+R E+ + R EP D ++E + + R+ E
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRF-------EPR-----DRQLEEEPGQRRRQKRQE 143
Query: 135 EEEEEIDDEEIERRRGMMRQRAQERKNEEM----EVMEVEDEGRSGEESESESEYEEYTD 190
+E E + EE ++ + QR ++R++EE+ + + +E R+ EE + E +
Sbjct: 144 QERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEE 203
Query: 191 SEDEMEPRLKPVF-IRKKDRVTVQEREAEA---LKQKELEQEAKRMAEERRKYTLKIVEE 246
DE + R + + +R+K R Q++ E + Q+E E+E ++ RK K+ EE
Sbjct: 204 FPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE 263
Query: 247 ETKK--ELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDRED--REALEKEKA 302
E ++ EL+E + L L+ E EEE + ++R ++++R +E+ RE E+ +
Sbjct: 264 EPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERRE 323
Query: 303 EIERMRNLTEEERRAELR 320
+ ER R EE R +LR
Sbjct: 324 QQER-REQQEERREQQLR 340
Score = 79.0 bits (193), Expect = 8e-15
Identities = 70/278 (25%), Positives = 127/278 (45%), Gaps = 25/278 (8%)
Query: 47 YAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRK 106
+ P + EE+ + +K +EQE E E EE S RL+ R + +E L R R+
Sbjct: 122 FEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQ---ERLEQRDRQRRDEELWRQRQ 178
Query: 107 IVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEV 166
E E A + + E EE DEE RRR ++ R + R+ ++ +
Sbjct: 179 --------EWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQR 230
Query: 167 MEVEDEGRSGEESESESEYEEYTDSEDEM----EPRLKPVFIRKKDRVTVQEREAEALKQ 222
E +D EE + + E E+E EP+ + +++++ ER+ ++
Sbjct: 231 RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290
Query: 223 KELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVR 282
+E EQ+ +R+ RR+ L+ +EE ++E +E +R + +EE ++R
Sbjct: 291 QEEEQQQQRL---RREQQLRRKQEEERREQQEERRE-------QQERREQQEERREQQLR 340
Query: 283 ELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELR 320
+ +R+++ R E+E+ E + R EE R +LR
Sbjct: 341 REQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Score = 78.6 bits (192), Expect = 1e-14
Identities = 71/307 (23%), Positives = 146/307 (47%), Gaps = 34/307 (11%)
Query: 67 KEQEAEPEEQEE--DSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDA 124
KEQ+ EE+EE + R R+ Q R + E+ +++ E E E
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ- 959
Query: 125 WRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDE-GRSGEESESES 183
+R +++ +++EE++ EE E+RR RQ +++ EE E+ + E++ R E
Sbjct: 960 YRKDKKL--QQKEEQLLGEEPEKRR---RQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014
Query: 184 EYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKI 243
E+E +DE++ + + ++++ +QERE + +++EL+QE +++ E R
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER------ 1068
Query: 244 VEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAE 303
E ++ELE R L + +EE+ + + +R +R+R+ RE E ++ E
Sbjct: 1069 -ETRRRQELERQYRKEEEL-------QQEEEQLLREEPEKRRRQERERQCREEEELQQEE 1120
Query: 304 IERMRNLTEEERRAEL-----------RANGKVITNKAVKGKYKFLQKYYHRGAFFMDED 352
+ +R E+ RR EL + +++ + K + + L++ Y E+
Sbjct: 1121 EQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE 1180
Query: 353 EEVYKRD 359
E++ + +
Sbjct: 1181 EQLLREE 1187
Score = 77.8 bits (190), Expect = 2e-14
Identities = 63/269 (23%), Positives = 130/269 (48%), Gaps = 17/269 (6%)
Query: 51 ESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEP 110
E E++ Q +K+ +E+ + ++EE++ + RR Q + EER R K+ E
Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEE 494
Query: 111 EVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEE-IERRRGMMRQRAQERKNEEMEVMEV 169
E E R E+E+ E+ + ++EE +++R +Q +E++ ++++
Sbjct: 495 E--RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552
Query: 170 EDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEA 229
E+E R +E + E + D++ LK R++ R+ + + E L+Q+ +E
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQL---LKREEERRQQRL--KREQEERLEQRLKREEV 607
Query: 230 KRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKR 289
+R+ +E R+ E+ K+E E +R L + ++ ++ + R +R+KR
Sbjct: 608 ERLEQEERR------EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR 661
Query: 290 DRED---REALEKEKAEIERMRNLTEEER 315
+ E+ + L++E E R + L EEE+
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQ 690
Score = 77.0 bits (188), Expect = 3e-14
Identities = 74/305 (24%), Positives = 147/305 (48%), Gaps = 26/305 (8%)
Query: 23 RNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKE---QEAEPEEQEED 79
R E E+ + + K+ +R D E ++E + + + + +E QE EP+ Q E
Sbjct: 212 RRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQREL 271
Query: 80 SSSDPRLRRLQNRI--SEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEE 137
+ +LR+L+ + E EE + R E ++ + + E R E+++ E++
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE------RREQQEERREQQ 325
Query: 138 EEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEP 197
E + +E ERR +R+ +ER+ +++ E E+E R E+ + EE + + E
Sbjct: 326 ERREQQE-ERREQQLRREQEERREQQLR-REQEEERR--EQQLRREQEEERREQQLRREQ 381
Query: 198 RLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELE-ENK 256
+L+ ++++ +E++ +Q EQ+ +R + RR+ L+ +EE + E + E +
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441
Query: 257 RSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDRE---ALEKEKAEIERMRNLTEE 313
R L + ++EE W RE + + ++E R+ ++E+ ER L EE
Sbjct: 442 RREQRL-------KREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEE 494
Query: 314 ERRAE 318
ERR +
Sbjct: 495 ERREQ 499
Score = 77.0 bits (188), Expect = 3e-14
Identities = 67/317 (21%), Positives = 150/317 (47%), Gaps = 26/317 (8%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPMESSD------EEDEEFQFIKKA--------- 66
+R E+ ++ E+ + +R + + +E + EE+++ Q +++
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE 312
Query: 67 --KEQEAEPEEQEE--DSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG 122
+EQ+ E EQ+E + + R ++L+ E E++L R ++ E + E E
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372
Query: 123 DAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESE 182
++ RE E++ ++++ R + + R++ R+ + ++ E + E E E
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432
Query: 183 SEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKR-MAEERRKYTL 241
+++ ++ E RLK ++D + +E E E +Q+ +Q+ KR EERR+ L
Sbjct: 433 RHEQKH--EQERREQRLKREQEERRDWLK-REEETERHEQERRKQQLKRDQEEERRERWL 489
Query: 242 KIVEEETKKELEENKRSLAALDALNTDD---ENDEEEYEAWKVRELKRIKRDREDREALE 298
K+ EEE +++ E ++ L + +EEE ++R ++++R++E+R
Sbjct: 490 KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549
Query: 299 KEKAEIERMRNLTEEER 315
++ E +R+ E+R
Sbjct: 550 LKREEEKRLEQERREQR 566
Score = 75.5 bits (184), Expect = 9e-14
Identities = 74/309 (23%), Positives = 140/309 (45%), Gaps = 43/309 (13%)
Query: 43 KRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQ-----------EEDSSSDPRLRRLQN 91
+R ++ E E+E+ Q K + +E EEQ + + R Q+
Sbjct: 176 QRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQD 235
Query: 92 RISEDVEERLARHRKIV---EPEVVGESD-------SEVEGDAWRMEREDSSEEEEEEID 141
R+ ++ EE+ R R+ V E E + E + E E ++ER++ E +EE
Sbjct: 236 RVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQ 295
Query: 142 DEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEES--------ESESEYEEYTDSED 193
++ RR +R++ +E + E+ E + E R +E E E E+ E
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQ 355
Query: 194 EMEPRLKPVFIRKKDRVTVQE--REAEALKQKEL--EQEAKRMAEERRKYTLKIVEEETK 249
E E R + + +++ Q+ RE + ++++L EQ+ +R + RR+ L+ E++ +
Sbjct: 356 EEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-REQQLR 414
Query: 250 KELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRN 309
+E + L L + E + E + + R +R+KR++E+R K + E ER
Sbjct: 415 RE-----QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETER--- 466
Query: 310 LTEEERRAE 318
E+ERR +
Sbjct: 467 -HEQERRKQ 474
Score = 74.3 bits (181), Expect = 2e-13
Identities = 72/274 (26%), Positives = 129/274 (47%), Gaps = 33/274 (12%)
Query: 67 KEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWR 126
+EQ+ E++EE R + R+ + EER ++ E E + E +
Sbjct: 421 REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE---RHEQERRKQQLK 477
Query: 127 MEREDSSEEE----EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESE 182
++E+ E EEE E+ ERR +R+ +ER+ + ++ E E+ + SE +
Sbjct: 478 RDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ 537
Query: 183 SEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALK--QKELEQEAKRMAEERRKYT 240
E+ E+ E LK R++++ QER + LK Q+E + + EERR+
Sbjct: 538 LRREQ----EERREQLLK----REEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR 589
Query: 241 LKIVEEETKKE---------LEENKRSLAALDALNTDDENDE-----EEYEAWKVRELKR 286
LK +EE ++ LE+ +R L ++E + EE E + ++L+R
Sbjct: 590 LKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRR 649
Query: 287 IKRD-REDREALEKEKAEIE-RMRNLTEEERRAE 318
+++ RE R E+E+ +E R++ EEERR +
Sbjct: 650 EQQERREQRLKREEEEERLEQRLKREHEEERREQ 683
Score = 73.9 bits (180), Expect = 3e-13
Identities = 85/353 (24%), Positives = 159/353 (45%), Gaps = 50/353 (14%)
Query: 23 RNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDS-S 81
R E+ ME + R G++ + EDE Q +++ +EQ+ +E++
Sbjct: 1590 RQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE--QLLQEREEQQLHRQERDRKFLE 1647
Query: 82 SDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEID 141
+P+LRR + + + R R RK E E + + E + R ER+ EEE+++
Sbjct: 1648 EEPQLRRQER----EQQLRHDRDRKFREEEQLLQEGEEQQ--LRRQERDRKFREEEQQLR 1701
Query: 142 DEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTD--SEDEMEPRL 199
+E ER+ +++ Q R+ E E++ R E E E Y E+++ P
Sbjct: 1702 RQERERK--FLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759
Query: 200 KPVFIRKKDRVTV--------QEREAEALKQKELEQ---EAKRMAEERRKYTLKI----- 243
+ +R+++R QERE + L+ +E ++ E +++ +ER + L+
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819
Query: 244 ----------VEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDRED 293
+EE+ ++ +E R A + T +++ EE E W+ E KR R++
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKR----RQE 1875
Query: 294 REALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGA 346
RE K E +R +EE+R R G++ + + KG + L+ H+ A
Sbjct: 1876 RE----RKLREEHIRRQQKEEQRH--RQVGEIKSQEG-KGHGRLLEPGTHQFA 1921
Score = 73.6 bits (179), Expect = 3e-13
Identities = 77/318 (24%), Positives = 140/318 (44%), Gaps = 21/318 (6%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPE-EQEEDS 80
+R E+ E ++ +++R +R EE E Q ++ +E+ E + +E++
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE 345
Query: 81 SSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWR---MEREDSSEEEE 137
+ +LRR Q + + R + + E ++ E E R + RE E+
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 138 EEIDDEEIER----RRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEY-EEYTDSE 192
+ ++++ R RR +R QE + E + + E R E E ++ + ++E
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465
Query: 193 DEMEPRLKPVFIR-----KKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEE 247
+ R K R +++R E E +Q+ EQ+ +R EERR+ LK EEE
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE 525
Query: 248 TKKELEENKRSLAALDALNTDDEND----EEEYEAWKVRELKRIKRDRED-REALEKEKA 302
+ L++ RS L + EEE + R +R+KR++E+ R+ L K +
Sbjct: 526 --ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREE 583
Query: 303 EIERMRNLTEEERRAELR 320
E + R E+E R E R
Sbjct: 584 ERRQQRLKREQEERLEQR 601
Score = 73.6 bits (179), Expect = 3e-13
Identities = 70/276 (25%), Positives = 129/276 (46%), Gaps = 22/276 (7%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGD 123
++ +EQ PEE+E++ R R + + EE+L R + ++ E D E
Sbjct: 803 RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERA--QQLQEEEDGLQEDQ 860
Query: 124 AWRMEREDSSEEEEEEIDDEEIERRRGMM--RQRAQERKNEEMEVMEVEDEGRSGEESES 181
R +E +++ +EE +RRR + + QE+ +E ++++ E+E EE E
Sbjct: 861 ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREK 920
Query: 182 E--SEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQ----------EA 229
E E E++++ + + ++++ QERE + K K+L+Q E
Sbjct: 921 RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEK 980
Query: 230 KRMAEERRKY----TLKIVEEE-TKKELEENKRSLAALDALNTDDENDEEEYEAWKVREL 284
+R E +KY L+ EE+ ++E E+ +R D+ EEE + RE
Sbjct: 981 RRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK 1040
Query: 285 KRI-KRDREDREALEKEKAEIERMRNLTEEERRAEL 319
+R+ +R+R+ RE E ++ E + + E RR EL
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Score = 72.0 bits (175), Expect = 1e-12
Identities = 77/347 (22%), Positives = 153/347 (44%), Gaps = 57/347 (16%)
Query: 55 EEDEEFQFIKKAKE----QEAEPEEQEEDSSSDPRLRRLQNRISED------VEERLARH 104
E ++E QF+++ ++ + A+ ++EED + + RR D +EE R
Sbjct: 826 EREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR 885
Query: 105 RKIVEPEVVGESDSEVEGDAWRMEREDSSEE----------------------EEEEIDD 142
R + + + E + E E+ E EEE++
Sbjct: 886 RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLR 945
Query: 143 EEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPV 202
EE E+RR R+R Q RK+++++ E + G E+ + ++Y + E+E++ + +
Sbjct: 946 EEREKRRRQERER-QYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYRE-EEELQQEEEQL 1003
Query: 203 FIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAAL 262
++++ QE E + K+ EL+QE +++ E R+ K+ L+E +R
Sbjct: 1004 LREEREKRRRQEWERQYRKKDELQQEEEQLLREERE----------KRRLQERERQYREE 1053
Query: 263 DALNTDDEN-DEEEYEAWKVRELKRIKRDRED---------REALEKEKAEIERMRNLTE 312
+ L ++E EE E + +EL+R R E+ RE EK + + ER R E
Sbjct: 1054 EELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQ-ERERQCRE 1112
Query: 313 EERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRD 359
EE + +++ + K + + L++ Y E+E++ + +
Sbjct: 1113 EEELQQ--EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREE 1157
Score = 71.2 bits (173), Expect = 2e-12
Identities = 68/282 (24%), Positives = 120/282 (42%), Gaps = 32/282 (11%)
Query: 50 MESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVE 109
++ EE+ +++K +E+ E +E+ E + R + R+ EE + R E
Sbjct: 476 LKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE 535
Query: 110 PEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQER-----KNEEM 164
++ E + E R E + +E E+ E E RR + +R +ER K E+
Sbjct: 536 QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE 595
Query: 165 EVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKE 224
E +E + E E E E+ E+ E R + + ++ +++ ++++ +Q+
Sbjct: 596 ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQL-LKSEEQEERRQQQLRREQQER 654
Query: 225 LEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVREL 284
EQ KR EE R +E+ K+E EE +R + E EEE E + R
Sbjct: 655 REQRLKREEEEER------LEQRLKREHEEERR----------EQELAEEEQEQARERIK 698
Query: 285 KRIKR----------DREDREALEKEKAEIERMRNLTEEERR 316
RI + R+ + K E +R R EE+RR
Sbjct: 699 SRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR 740
Score = 71.2 bits (173), Expect = 2e-12
Identities = 67/353 (18%), Positives = 151/353 (42%), Gaps = 41/353 (11%)
Query: 23 RNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSS 82
R E+ E+ + + + + P + S+ + + + + ++QE + QE++
Sbjct: 680 RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE-- 737
Query: 83 DPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDD 142
+ RR ++ + EER R + + + + W+ + E+ SE + +
Sbjct: 738 --KRRRRESELQWQEEERAHRQQ---------QEEEQRRDFTWQWQAEEKSERGRQRLSA 786
Query: 143 EEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYE-EYTDSEDEMEPRLKP 201
R + + RA+ER+ E + E+E E E E ++ + E++++
Sbjct: 787 RPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQ----- 841
Query: 202 VFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKI-VEEETKKELEENKRSLA 260
+++R + E + L++ +QE +R E+RR + +EEE K+ A
Sbjct: 842 ----RRERAQQLQEEEDGLQE---DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA 894
Query: 261 ALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEE------- 313
+ L + + +EE E + E ++ +R ++R+ E+E+ + E + L EE
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ 954
Query: 314 ERRAELRANGK-------VITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRD 359
ER + R + K ++ + K + + +K Y E+E++ + +
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE 1007
Score = 67.0 bits (162), Expect = 3e-11
Identities = 74/283 (26%), Positives = 132/283 (46%), Gaps = 29/283 (10%)
Query: 51 ESSDEEDEEFQFIKKAKEQEAEP--EEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIV 108
E ++++ Q +++ +E+ E + QEE+ RLR Q ++ + EER + K
Sbjct: 495 ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ-QLRREQEERREQLLKRE 553
Query: 109 EPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQER-KNEEMEVM 167
E + + + E + ER D + EEE + ++R + +R ++R K EE+E +
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ---EERLEQRLKREEVERL 610
Query: 168 EVED--EGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKE- 224
E E+ E R E E ++ SE++ E R +++ R QER + LK++E
Sbjct: 611 EQEERREQRLKREEPEEERRQQLLKSEEQEERR------QQQLRREQQERREQRLKREEE 664
Query: 225 ---LEQEAKRMAEERRKYTLKIVEEETKKELEENKRSL--------AALDALNTDDENDE 273
LEQ KR EE R+ ++ EEE ++ E K + + DA + +
Sbjct: 665 EERLEQRLKREHEEERR-EQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP 723
Query: 274 EEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERR 316
+ E + R+ + KR R + E +E+ R + EE+RR
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQ-EEEQRR 765
Score = 65.9 bits (159), Expect = 7e-11
Identities = 72/311 (23%), Positives = 144/311 (46%), Gaps = 27/311 (8%)
Query: 45 PDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEED---SSSDPRLRRLQNRISEDVEERL 101
P+ +E ++++ + + K +E++ EE+EE +D + R + + E E+ L
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353
Query: 102 ARH---RKIVEPEV----VGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQ 154
R RK E E+ G E E R ERE +EE+++ +E E++ +RQ
Sbjct: 1354 RRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ---LRQ 1410
Query: 155 RAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRK--KDRVTV 212
+ EE + + ++ R E E + +E E E +L+ RK ++ +
Sbjct: 1411 DRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLL 1470
Query: 213 QEREAEALKQKE-----LEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNT 267
QERE + L ++E LE+E + +ER + K E+E + + E ++ L L+
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDR---KFREQELRSQ-EPERKFLEEEQQLHR 1526
Query: 268 DDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMR---NLTEEERRAELRANGK 324
+ E ++R +R ++ R+DR+ +E+ ++ + R L+ +ER + R +
Sbjct: 1527 QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQ 1586
Query: 325 VITNKAVKGKY 335
+ + + K+
Sbjct: 1587 KVRRQEQERKF 1597
Score = 64.7 bits (156), Expect = 2e-10
Identities = 70/340 (20%), Positives = 142/340 (41%), Gaps = 52/340 (15%)
Query: 23 RNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEE------- 75
+ E+ E +++ +V+R +R + EE+ Q +K +++E ++
Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653
Query: 76 --------QEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGES-DSEVEGDAWR 126
+EE+ + RL+R E EER + E E E S + W+
Sbjct: 654 RREQRLKREEEEERLEQRLKR------EHEEERREQELAEEEQEQARERIKSRIPKWQWQ 707
Query: 127 MERE-DSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEY 185
+E E D+ + + ++ +RR ++ + R+ E++ E E R +E E ++
Sbjct: 708 LESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDF 767
Query: 186 EEYTDSEDEME---------PRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEER 236
+E++ E P L+ R+ Q+RE L ++E +++ +R ER
Sbjct: 768 TWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER 827
Query: 237 RKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYE------AWKVRELKRIKRD 290
K + EEE + E ++ D L D E + + W++ E ++ +R
Sbjct: 828 EKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRH 887
Query: 291 ------------REDREALEKEKAEIERMRNLTEEERRAE 318
R++++ L++E+ E++R E+ RR E
Sbjct: 888 TLYAKPALQEQLRKEQQLLQEEEEELQREER--EKRRRQE 925
Score = 62.8 bits (151), Expect = 6e-10
Identities = 69/355 (19%), Positives = 148/355 (41%), Gaps = 63/355 (17%)
Query: 25 EKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEF-----------QFIKKAKEQEAEP 73
++ E + + + KR + + Y E +E+E+ + ++ +++E
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQ 1087
Query: 74 EEQEEDSSSDPRLRRLQNRISE--------DVEERLARH----RKIVEPEVVGESDSEVE 121
+E+E+ +P RR Q R + EE+L R R+ E E + EV+
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQ 1147
Query: 122 GDAWRMEREDSS------------EEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV 169
+ ++ RE+ EEEE + ++E++ R R++ +ER+ E E ++
Sbjct: 1148 QEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQR 1207
Query: 170 EDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEA 229
+ + + + S+ + + E E R V+ + ++ ++ E L+ ++ +Q+
Sbjct: 1208 QKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDL 1267
Query: 230 KRM---------AEERRKYTLK---------IVEEETKKELEENKRSLAALDALNTD--- 268
+ + +ERR++ + + EE K+ +++S L +
Sbjct: 1268 QHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREE 1327
Query: 269 -------DENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERR 316
D EE + + RE + ++R DR+ E+E E+ R EEE+R
Sbjct: 1328 KRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQR 1382
Score = 59.7 bits (143), Expect = 5e-09
Identities = 67/344 (19%), Positives = 158/344 (45%), Gaps = 28/344 (8%)
Query: 32 EKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQN 91
++++ +R+ + + E +++ + +K E+E + QE D + R Q
Sbjct: 1453 QQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQE 1512
Query: 92 RISEDVEE-----RLARHRKIVEPEVV------GESDSEVEGDAWRMEREDSSEEEEEEI 140
+ +EE R R RK ++ E G+ + +R E + E EE+++
Sbjct: 1513 PERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQL 1572
Query: 141 DDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDE---MEP 197
+E +R+ + Q+ + R+ +E + ME E + R E + + + EDE E
Sbjct: 1573 SRQERDRKFRLEEQKVR-RQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER 1631
Query: 198 RLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKR 257
+ + +++DR ++E L+++E EQ+ + + + + ++++E +++L +R
Sbjct: 1632 EEQQLHRQERDRKFLEEE--PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER 1689
Query: 258 SLAALDALNTDDENDEEEYEAWKVRELKRIKRDRE-DREALEKEKAEIERMRNLTEEERR 316
+EE+ + RE K ++ +++ R+ LE++ E E++R TE+E+
Sbjct: 1690 DRKF---------REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740
Query: 317 AELRANGKVITNKAVKGKYKFLQ-KYYHRGAFFMDEDEEVYKRD 359
K++ + ++ + + Q + R F +E++ +R+
Sbjct: 1741 RRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE 1784
Score = 59.3 bits (142), Expect = 7e-09
Identities = 81/361 (22%), Positives = 164/361 (45%), Gaps = 30/361 (8%)
Query: 25 EKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKA---KEQEAEPEEQEEDSS 81
E+ E+ E+ ++ R KR +E E+EE Q ++ +EQE +E+E
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQE-LERQYREEEELQQEEEQLLREEQEKRRQERERQYR 1200
Query: 82 SDPRLRRLQNRISEDVEERLARHRKIVEPEVVGE-SDSEV-----EGDAWRMEREDSSEE 135
+ L+R + + E++ + + EPE D++V E + +R + EDS
Sbjct: 1201 EEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFR-QLEDSQLR 1259
Query: 136 EEEEIDDEEIERRRGMMRQRAQERKN--------EEMEVMEVEDEGRSGEESESESEYEE 187
+ + D + R R QER+ E E +E E++ + + + +S+ E+
Sbjct: 1260 DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ-KEAKRRDRKSQEEK 1318
Query: 188 YTDSEDEMEPRLKPVFIRK--KDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVE 245
E+ E R + RK ++ +QERE + L+++E +++ + ++ K +E
Sbjct: 1319 QLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLE 1378
Query: 246 EETKKELEENKRSLAALDALNTDDENDEE--EYEAWKVRE----LKRIKRDREDREALEK 299
EE + +E +R + E +++ + K RE L R +RDR+ RE E+
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREE-EQ 1437
Query: 300 EKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKY-YHRGAFFMDEDEEVYKR 358
+ ER R EEE++ + K + + + + Q + R F++E++++ ++
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497
Query: 359 D 359
+
Sbjct: 1498 E 1498
Score = 58.2 bits (139), Expect = 1e-08
Identities = 71/305 (23%), Positives = 135/305 (44%), Gaps = 41/305 (13%)
Query: 44 RPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRI------SEDV 97
RP + +E EE K + +E+E + QEE+ + + Q R +E+
Sbjct: 722 RPRKQEGQRRRQEQEE-----KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEK 776
Query: 98 EERLARHRKIVEPEVVGESDSEVEGDAWRMEREDS--SEEEEEE---IDDEEIERRRGMM 152
ER R R P + + + ++ + R +RE EEEE+E E E+ +
Sbjct: 777 SER-GRQRLSARPPLREQRERQLRAEE-RQQREQRFLPEEEEKEQRRRQRREREKELQFL 834
Query: 153 RQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDS------EDEMEPRLKPVFIR- 205
+ Q ++ E + ++ E++G E+ E E+ D E+E + R ++ +
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGLQ-EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893
Query: 206 ------KKDRVTVQEREAEALKQKELEQEAKRMAEERRKY----TLKIVEEETKKELEEN 255
+K++ +QE E E ++ E+E +R E+ R+Y L+ EE+ +E E
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQRE---EREKRRRQEQERQYREEEQLQQEEEQLLREEREK 950
Query: 256 KRSLAALDALNTDD--ENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEE 313
+R D + EE+ + + +R +R+++ RE E ++ E + +R E+
Sbjct: 951 RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREK 1010
Query: 314 ERRAE 318
RR E
Sbjct: 1011 RRRQE 1015
Score = 37.0 bits (84), Expect = 0.036
Identities = 29/142 (20%), Positives = 67/142 (47%), Gaps = 1/142 (0%)
Query: 218 EALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYE 277
E+L Q ++E +R E R + + + +++ +E +R LA + + E E+
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDR 166
Query: 278 AWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGK-YK 336
+ EL R +++ ++RE E+ +++ + EE E + + + KG+ K
Sbjct: 167 QRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEK 226
Query: 337 FLQKYYHRGAFFMDEDEEVYKR 358
Q+ + F +E+E+ +++
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRK 248
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 83.2 bits (204), Expect = 4e-16
Identities = 68/285 (23%), Positives = 135/285 (47%), Gaps = 32/285 (11%)
Query: 32 EKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQN 91
EK++ ++ E +E+E+ + +K +EQEA+ QEE ++R +
Sbjct: 391 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE------KIREQEE 444
Query: 92 RISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGM 151
+I E ++ + KI E E + E + R E+E+ +EE+ + EEI R++
Sbjct: 445 KIREQEKKMWRQEEKIHEQEKIREEEK-------RQEQEEMWRQEEKIHEQEEIWRQKEK 497
Query: 152 MRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVT 211
M ++ ++ + +E +V E++ R EE E E + + E + R + R+++++
Sbjct: 498 MHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEE---KIREQEEMWREEEKMH 554
Query: 212 VQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDEN 271
QE+ E K++E E + R E+ R+ K+ +E K +E KR
Sbjct: 555 EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKR-------------- 600
Query: 272 DEEEYEAWKVRELKRIKRDR--EDREALEKEKAEIERMRNLTEEE 314
E+E + WK E R + ++ E E + +++ +I +T+E+
Sbjct: 601 QEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQ 645
Score = 78.6 bits (192), Expect = 1e-14
Identities = 73/305 (23%), Positives = 143/305 (46%), Gaps = 19/305 (6%)
Query: 23 RNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDS-S 81
R E+ EK++ + + + E E++E ++ +K EQE + +QEE
Sbjct: 455 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWR 514
Query: 82 SDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEV--EGDAW----RMEREDSSEE 135
+ ++R + +I E E+ + KI E E + + ++ + W R E+ED
Sbjct: 515 QEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWR 574
Query: 136 EEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEM 195
+EE+I ++E + R + R QE K +E E + E + E+ E E EE ++E
Sbjct: 575 QEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEK 634
Query: 196 EPRLKPVFIRKKDRVTVQEREAEALKQKE--LEQEAKRMAEERRKYTLKIVEEETKKELE 253
IR+++ +T QE+E + +Q+E EQE K +E + + E +K++
Sbjct: 635 --------IREQEEMT-QEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIR 685
Query: 254 ENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEE 313
E + + + + + E E E K+ E + +++E++ ++EK + +R +E
Sbjct: 686 EQEEKIREQEEMMQEQEEKMWEQEE-KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQE 744
Query: 314 ERRAE 318
E+ E
Sbjct: 745 EKMQE 749
Score = 72.4 bits (176), Expect = 8e-13
Identities = 61/241 (25%), Positives = 110/241 (45%), Gaps = 26/241 (10%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPM----ESSDEEDEEFQFIKKAKEQEAEPEEQE 77
+R ++ ++ ++ K++ R M E E++E ++ +K EQE EE++
Sbjct: 505 IRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEK 564
Query: 78 EDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEE 137
D ++ R + +I E E+ + KI E E E E E W+ E + +EE+
Sbjct: 565 RQEQED-KMWRQEEKIREQEEKVWRQEEKIREQE---EKRQEQEEKMWKQEEKIREQEEK 620
Query: 138 EEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEP 197
+ +E+I R QE K E E M E E + GE+ E E EE ++E
Sbjct: 621 IQEQEEKI---------REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEE--- 668
Query: 198 RLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTL--KIVEEETKKELEEN 255
R+++++ QE++ ++K EQE +E + + K+ E+E K + +E
Sbjct: 669 ----TMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 724
Query: 256 K 256
K
Sbjct: 725 K 725
Score = 70.9 bits (172), Expect = 2e-12
Identities = 78/345 (22%), Positives = 153/345 (44%), Gaps = 47/345 (13%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKR---PDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEE 78
V +EK EI + ++KR + + P +D +E Q + + + +A+ EE E
Sbjct: 233 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV--SAKLQAQVEENE- 289
Query: 79 DSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEE 138
L NR+++ EE++ WR +E+ +E EE
Sbjct: 290 ----------LWNRLNQQQEEKM-----------------------WR--QEEKIQEWEE 314
Query: 139 EIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPR 198
+I ++E + R + R QE K E M E E + + E E EE ++EM
Sbjct: 315 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 374
Query: 199 LKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRS 258
+ R+++ + +E + L++K EQE R EE+R+ KI E+E ++E +E K
Sbjct: 375 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE-QEAKMW 433
Query: 259 LAALDALNTDDENDEEEYEAW----KVRELKRIKRDREDREALEKEKAEIERMRNLTEEE 314
+++ E+E + W K+ E ++I R+ E R+ E+ + E++ E
Sbjct: 434 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKI-REEEKRQEQEEMWRQEEKIHEQEEIW 492
Query: 315 RRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRD 359
R+ E + K + ++ +K + +++E++++++
Sbjct: 493 RQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQE 537
Score = 70.5 bits (171), Expect = 3e-12
Identities = 72/316 (22%), Positives = 144/316 (45%), Gaps = 32/316 (10%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEE---DEEFQFIKKAK---------EQ 69
++ ++ +I ++ K++ R M +E+ EE + K+ K E+
Sbjct: 316 IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 375
Query: 70 EAEPEEQEEDS-SSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRME 128
E + QEE + ++R L+ ++ E + R + K E E + E + E +A
Sbjct: 376 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR-EQEEKRQEEEKIREQEKRQEQEAKMWR 434
Query: 129 REDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEY 188
+E+ E+EE+I ++E + R + QE+ EE + E E+ R E+ + E
Sbjct: 435 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQ 494
Query: 189 TDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEET 248
+ E E +++ +++++V QE + ++K EQE K +E KI E+E
Sbjct: 495 KEKMHEQEEKIR----KQEEKVWRQEEKIREQEEKIREQEEKMWRQEE-----KIREQE- 544
Query: 249 KKELEENKRSLAALDALNTDDENDEEEYEAW----KVREL--KRIKRDREDREALEKEKA 302
E+ + + + + +++ E+E + W K+RE K +++ + RE EK +
Sbjct: 545 --EMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQE 602
Query: 303 EIERMRNLTEEERRAE 318
+ E+M E+ R E
Sbjct: 603 QEEKMWKQEEKIREQE 618
Score = 67.4 bits (163), Expect = 2e-11
Identities = 66/269 (24%), Positives = 124/269 (46%), Gaps = 22/269 (8%)
Query: 55 EEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVG 114
E++E+ + +++ ++ + EQEE + ++R + R E + + KI E E
Sbjct: 388 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR-QEQEAKMWRQEEKIREQE--- 443
Query: 115 ESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGR 174
E E E WR +EE+I ++E + R RQ +E +E ++ E E+ R
Sbjct: 444 EKIREQEKKMWR---------QEEKIHEQE-KIREEEKRQEQEEMWRQEEKIHEQEEIWR 493
Query: 175 SGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAE 234
+ E E EE ++E R + +++++ QE + ++K EQE E
Sbjct: 494 ---QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREE 550
Query: 235 ERRKYTLKIVEEETKKELE-----ENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKR 289
E+ KI EEE ++E E + ++ + + +E E+ E + +E K K+
Sbjct: 551 EKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610
Query: 290 DREDREALEKEKAEIERMRNLTEEERRAE 318
+ + RE EK + + E++R E+ R E
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQE 639
Score = 43.9 bits (102), Expect = 3e-04
Identities = 36/152 (23%), Positives = 68/152 (44%), Gaps = 23/152 (15%)
Query: 54 DEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLA-RHRKIVEPEV 112
++E++ ++ +K +EQE + +EQEE R Q ++++ EE++ + K+ E E
Sbjct: 602 EQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQE- 660
Query: 113 VGESDSEVEGDAWRME-------------------REDSSEEEEEEIDDEEIERRRGMMR 153
E E E WR E +E+ +E+EE++ ++E + +
Sbjct: 661 --EKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 718
Query: 154 QRAQERKNEEMEVMEVEDEGRSGEESESESEY 185
+ QE K E E E R ++ E E+
Sbjct: 719 MQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEH 750
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 82.8 bits (203), Expect = 6e-16
Identities = 69/291 (23%), Positives = 140/291 (48%), Gaps = 20/291 (6%)
Query: 32 EKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQN 91
EK++ ++ E +E+E+ + +K +EQEA+ QEE ++R +
Sbjct: 377 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE------KIREQEE 430
Query: 92 RISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGM 151
+I E ++ + KI E E + E + R E+E+ +EE+ + EEI R++
Sbjct: 431 KIREQEKKMWRQEEKIHEQEKIREEEK-------RQEQEEMWRQEEKIREQEEIWRQKEK 483
Query: 152 MRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSED--EMEPRLKPVFIRKKDR 209
M ++ + RK EE +V E++ EE E E + + E E E +++ ++++
Sbjct: 484 MHEQEKIRKQEE-KVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIR----EQEEK 538
Query: 210 VTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDD 269
+ QE + ++K EQE K +E+ + + + E+ +K E+ ++ + + +
Sbjct: 539 IREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQE 598
Query: 270 ENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELR 320
E E+ E + +E K +++ + E EK + + E+MR E+ E+R
Sbjct: 599 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVR 649
Score = 64.3 bits (155), Expect = 2e-10
Identities = 79/351 (22%), Positives = 164/351 (46%), Gaps = 32/351 (9%)
Query: 29 ISMEKVKVKRYVSG--KRPDYAPMES-----SDEEDEEFQFIKKAKEQEAEPEEQEEDSS 81
++ +K K RY+ K D +E +DEE +E K AK QE + E S
Sbjct: 184 VATQKKKADRYIEELTKERDALSLELYRNTITDEELKE----KNAKLQEKLQLVESEKSE 239
Query: 82 SDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEV---------EGDAWRMEREDS 132
++ L+ ++ E + L + + E + +G+ V E + W R +
Sbjct: 240 IQLNVKELKRKL-ERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN--RLNQ 296
Query: 133 SEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSE 192
+EE+ +E+I+ ++++ ++ + +E ++ E E++ R EE E E E +
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE--EKMRRQ 354
Query: 193 DEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKEL 252
+EM + R ++ + +E + L++K EQE R EE+R+ KI E+E ++E
Sbjct: 355 EEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE- 413
Query: 253 EENKRSLAALDALNTDDENDEEEYEAW----KVRELKRIKRDREDREALEKEKAEIERMR 308
+E K +++ E+E + W K+ E ++I R+ E R+ E+ + E++R
Sbjct: 414 QEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKI-REEEKRQEQEEMWRQEEKIR 472
Query: 309 NLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRD 359
E R+ E + I + K ++ +K + + +++E++++++
Sbjct: 473 EQEEIWRQKEKMHEQEKIRKQEEK-VWRQEEKMHDQEEKIREQEEKMWRQE 522
Score = 63.2 bits (152), Expect = 5e-10
Identities = 52/240 (21%), Positives = 115/240 (47%), Gaps = 15/240 (6%)
Query: 23 RNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSS 82
R E+ EK++ + + + E E++E ++ +K EQE +++E+
Sbjct: 441 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQ 500
Query: 83 DPRLRRLQNRISEDVEERLARHRKIVE-PEVVGESDSEVEGDAWRMEREDSSEEEEEEID 141
+ ++ + +I E E+ + KI E E + E + ++ E+E+ +E+EE++
Sbjct: 501 EEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIR------EQEEMMQEQEEKMG 554
Query: 142 DEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKP 201
++E E+ + + R QE K E E E + + E+ E E EE ++EM
Sbjct: 555 EQE-EKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEM------ 607
Query: 202 VFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAA 261
+++++ QE + ++K EQE K +E + + ++ + +++++E++ L A
Sbjct: 608 -MQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 666
Score = 58.9 bits (141), Expect = 9e-09
Identities = 65/295 (22%), Positives = 129/295 (43%), Gaps = 44/295 (14%)
Query: 25 EKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDP 84
E+ E E+ K++ + + A M +E+ E + +K +EQE + QEE
Sbjct: 394 EQEEKRQEEEKIREQEKRQEQE-AKMWRQEEKIREQE--EKIREQEKKMWRQEEKIHEQE 450
Query: 85 RLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEV---------EGDAWRMEREDSSEE 135
++R + R ++ EE + KI E E + ++ E WR E + +E
Sbjct: 451 KIREEEKR--QEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQE 508
Query: 136 E------------EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESES 183
E EE+I ++E + R + R QE +E E E E + E+ +
Sbjct: 509 EKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRR 568
Query: 184 EYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKI 243
+ E+ + E+++ + + + ++ + E+E + +Q+E+ QE + E+ + K+
Sbjct: 569 QEEKIREQEEKIREQKEKI---REQEEKIWEQEEKIREQEEMMQEQEEKMWEQEE---KM 622
Query: 244 VEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALE 298
E+E K + +E K EE+ +VR ++ ++ +E +E LE
Sbjct: 623 CEQEEKMQEQEEKM------------RRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 50.8 bits (120), Expect = 2e-06
Identities = 41/172 (23%), Positives = 84/172 (48%), Gaps = 11/172 (6%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSS 81
+ +++ +I ++ K+ R R + +E+ E + + +EQE + EQEE
Sbjct: 504 MHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQE--EMMQEQEEKMGEQEEKMQ 561
Query: 82 SDPRLRRLQNRISEDVEERLARHRKIVEPEV-VGESDSEV-EGDAWRMEREDSSEEEEEE 139
++RR + +I E E+ + KI E E + E + ++ E + E+E+ E+EE+
Sbjct: 562 EQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEK 621
Query: 140 IDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDS 191
+ ++E + + + R QE K E EV R ++ E E++E+ ++
Sbjct: 622 MCEQEEKMQEQEEKMRRQEEKMWEQEV-------RLRQQEEKMQEHQEHLEA 666
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 82.4 bits (202), Expect = 7e-16
Identities = 76/306 (24%), Positives = 136/306 (44%), Gaps = 33/306 (10%)
Query: 54 DEEDEEFQFIKKAKEQEAEPE-EQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEV 112
D + E+ + +K +E+E E E E+ D +D + R + R +E ER + + E
Sbjct: 114 DRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTER 173
Query: 113 VGESDSEVEGDAWRMEREDSSEEEEEEIDDE----------------EIERRRGMMRQRA 156
+ + E E + + E+E + +D E ER+R R+R
Sbjct: 174 NRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERD 233
Query: 157 QERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKP---VFIRKKDRVTVQ 213
++RK E + E E S E+E + E E D + + + R K RK+ R T +
Sbjct: 234 RQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTER 293
Query: 214 EREAEALKQKELEQEAKR---------MAEERRKYTLKIVEEETKKELEENKRSLAALDA 264
+RE E ++++ E+E +R ER + + E + +KE E ++ +D
Sbjct: 294 DRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDR 353
Query: 265 LNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEE-ERRAELRANG 323
E +A + RE +R+R+ + A E+E+ E +R R+ +E ER+ E +G
Sbjct: 354 ERNRQTGREGRRQAERERER---ERERDRQSAREREERERDRDRDRQKERERQTEKDRDG 410
Query: 324 KVITNK 329
+ T K
Sbjct: 411 QRETEK 416
Score = 74.7 bits (182), Expect = 2e-13
Identities = 74/302 (24%), Positives = 125/302 (41%), Gaps = 16/302 (5%)
Query: 23 RNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSS 82
RN + E EK + +R +R ++ D E + ++ +E E E E + +
Sbjct: 173 RNRQKEREREKNRQERR-ERERQREKENKTEDRHSERGRERERERETETETERKRQTDRE 231
Query: 83 DPRLRRLQNRISEDVEERLARHRKIV-EPEVVGESDSEVEGDAWRMEREDSSEEEEEEID 141
R R+ + + E A R+ + E E D + + D + ERE ++ + +
Sbjct: 232 RDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRT 291
Query: 142 DEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKP 201
+ + E R RQR +ER+ E E E E E E E + E D E E E
Sbjct: 292 ERDRETERKRERQRERERERERNRKRERERE----RERERERQRETERDREKERE----- 342
Query: 202 VFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAA 261
RK+ R T +RE +E ++A+R E R+ + E ++E + ++
Sbjct: 343 ---RKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKE 399
Query: 262 LDALNTDDENDEEEYEAWKVRELKR-IKRDREDREALEKEKA-EIERMRNLTEEERRAEL 319
+ D + + E E + RE R +R RE EK+K E +R R + R
Sbjct: 400 RERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRK 459
Query: 320 RA 321
R+
Sbjct: 460 RS 461
Score = 74.3 bits (181), Expect = 2e-13
Identities = 78/318 (24%), Positives = 141/318 (44%), Gaps = 29/318 (9%)
Query: 23 RNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSS 82
R ++ E EK + +R KR + + D + + +++E E E Q D
Sbjct: 58 RQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRE---RQRDREKERERQT-DRER 113
Query: 83 DPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWR-MEREDSSEEEEEEID 141
D + + +NR E E + + + G+ + E + DA + ER+ E + +
Sbjct: 114 DRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTER 173
Query: 142 DEEIERRRGMMRQRAQERKNEEMEVMEVEDE----GRSGE---ESESESEYEEYTDSEDE 194
+ + ER R RQ +ER+ + + + ED GR E E+E+E+E + TD E +
Sbjct: 174 NRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERD 233
Query: 195 MEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEE-------- 246
+ + + ++ +R ERE E K++E E++ R + R+K + +
Sbjct: 234 RQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTER 293
Query: 247 --ETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDRE-DREALEKEKAE 303
ET+++ E + + + E E E + RE +RDRE +RE K + E
Sbjct: 294 DRETERKRERQRERERERERNRKRERERERERERERQRE---TERDREKERERKRKRQTE 350
Query: 304 IERMRNL---TEEERRAE 318
++R RN E R+AE
Sbjct: 351 MDRERNRQTGREGRRQAE 368
Score = 71.6 bits (174), Expect = 1e-12
Identities = 57/261 (21%), Positives = 110/261 (42%), Gaps = 20/261 (7%)
Query: 69 QEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRME 128
++A+ +++E + + RR + + + + + R R E D + D R
Sbjct: 47 KDADGDDRERNRQKERERRREKRQTERETDRKRERRR---------EKDRHRKRDRHRER 97
Query: 129 REDSSEEEEEEIDDE-----EIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESES 183
+ D +E E + D E E ER R R+R ER+ E + + + + ++E
Sbjct: 98 QRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEK 157
Query: 184 EYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKI 243
E E TD E + + R++++ + RE E ++KE + E + R + +
Sbjct: 158 ERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERE 217
Query: 244 VEEETK------KELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREAL 297
E ET+ +E + +++ + + E E E K RE +R + DR
Sbjct: 218 TETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQK 277
Query: 298 EKEKAEIERMRNLTEEERRAE 318
E+E+ + + TE +R E
Sbjct: 278 ERERQTDRKRQRRTERDRETE 298
Score = 64.7 bits (156), Expect = 2e-10
Identities = 61/217 (28%), Positives = 101/217 (46%), Gaps = 16/217 (7%)
Query: 113 VGESDSEVEGDAWRMEREDSSEEEEEEID-----DEEIERRRGMMRQRAQERKNEEMEVM 167
+G++ + +GD R+ E E+ D + ERRR R R ++R E
Sbjct: 42 LGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDR 101
Query: 168 EVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQ 227
E E E ++ E + + E E E E E + R +DR T +RE E +Q++ E+
Sbjct: 102 EKERERQTDRERDRQREKERNRQKERERETEREGE--RGRDRQTDGQRERE--RQRDAEK 157
Query: 228 EAKRMAE-ERRKYTLKIVEEETKKE---LEENKRSLAALDALNTDDENDEEEYEAWKVRE 283
E +R + ER++ T + ++E ++E E +R T+D + E E + RE
Sbjct: 158 ERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERE 217
Query: 284 LK-RIKRDRE-DREALEKEKAEIERMRNLTEEERRAE 318
+ +R R+ DRE + K E ER + E ER +E
Sbjct: 218 TETETERKRQTDRERDRQRKTEREREKQ-AERERASE 253
Score = 46.6 bits (109), Expect = 4e-05
Identities = 44/182 (24%), Positives = 82/182 (45%), Gaps = 18/182 (9%)
Query: 143 EEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPV 202
+E RRRG+ Q ++ ++ E ++ R E+ ++E E + + E + K
Sbjct: 34 QESPRRRGL-GQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRD 92
Query: 203 FIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAAL 262
R++ R +ERE + ++++ ++E +R ++ R E ET++E E +
Sbjct: 93 RHRERQRDREKERERQTDRERDRQREKERNRQKER-------ERETEREGERGR------ 139
Query: 263 DALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRAN 322
D E + +A K RE + DRE + E+ + + ER R +ERR R
Sbjct: 140 DRQTDGQRERERQRDAEKERER---QTDRERQRQTERNRQK-EREREKNRQERRERERQR 195
Query: 323 GK 324
K
Sbjct: 196 EK 197
Score = 44.3 bits (103), Expect = 2e-04
Identities = 40/199 (20%), Positives = 79/199 (39%), Gaps = 11/199 (5%)
Query: 23 RNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSS 82
R ++ E ++ + +R + + + E E + K+ +E+E E E + + +
Sbjct: 275 RQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETE 334
Query: 83 DPRLRRLQNRISEDVEERLARHRKIV-EPEVVGESDSEVEGDAWRMEREDSSEEEEEEID 141
R + + + E R+R+ E E + E E + R + E E +
Sbjct: 335 RDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDR 394
Query: 142 DEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKP 201
D + ER R + R +R+ E+ E + E G E E E ++ + + E
Sbjct: 395 DRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRE------- 447
Query: 202 VFIRKKDRVTVQEREAEAL 220
R+ DR ++R+ L
Sbjct: 448 ---RQTDRQAGRQRKRSTL 463
Score = 34.7 bits (78), Expect = 0.18
Identities = 30/113 (26%), Positives = 48/113 (42%), Gaps = 1/113 (0%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGD 123
++ E+E E E + + S+ R R ++R + +ER + K + + E E E D
Sbjct: 364 RRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKD 423
Query: 124 AWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSG 176
ER E E+ E +R R RQ ++RK + V RSG
Sbjct: 424 R-ESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSG 475
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 81.3 bits (199), Expect = 2e-15
Identities = 69/293 (23%), Positives = 138/293 (47%), Gaps = 20/293 (6%)
Query: 32 EKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQN 91
EK++ + + + E + E EE K ++QE EQEE RL +
Sbjct: 444 EKMQEEERIREREKKMREEEETMREQEE-----KMQKQEENMWEQEEKEWQQQRLPEQKE 498
Query: 92 RISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGM 151
++ E E+ + KI E E E+ G +M R++ E+E+++ ++E + R
Sbjct: 499 KLWEQ-EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 557
Query: 152 MRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVT 211
+ QE E ME E E ++ ++ E E E + E +M + + +++++
Sbjct: 558 QKMWDQE---ERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREE-EEMMREQEEKMQ 613
Query: 212 VQEREAEALKQKELEQEAKRMAEERRKYTL--KIVEEETK----KELEENKRSLAALDAL 265
QE + + ++K EQE K +E + + K+ E+E K + L E K L + +
Sbjct: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
Query: 266 NTDDENDEEEYEAWKVRELKRIKRDRE----DREALEKEKAEIERMRNLTEEE 314
++ E+E + W+ ++++ +++E D+E + +E++ ER + + EEE
Sbjct: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726
Score = 80.5 bits (197), Expect = 3e-15
Identities = 73/302 (24%), Positives = 150/302 (49%), Gaps = 27/302 (8%)
Query: 24 NEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDS-SS 82
+EK EI + ++KR + + ++++ ++E ++ ++ +EQE + +QEE
Sbjct: 239 SEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ 298
Query: 83 DPRLRRLQNRISEDVEERLARHRKIVEPEV-VGESDSEV-------EGDAWRMEREDSSE 134
+ RLR + ++ E E+ + +++ E E + E + E+ E + E+E+
Sbjct: 299 EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMW 358
Query: 135 EEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDE 194
E+EE++ ++E + R R QE++ E E + E R E+ E E EE +++
Sbjct: 359 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK 418
Query: 195 MEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEE 254
M +++ + KK +QE+E + Q+E QE +R+ E +K EEET +E EE
Sbjct: 419 MWEQVEKMREEKK----MQEQEKKTRDQEEKMQEEERIREREKKMR---EEEETMREQEE 471
Query: 255 NKRSLAALDALNTDDEND-EEEYEAWKVRELKRIKRDREDREALEKEKAEI-ERMRNLTE 312
+ +EN E+E + W+ + L K ++E +++++ +I E+ + +
Sbjct: 472 K---------MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 522
Query: 313 EE 314
+E
Sbjct: 523 QE 524
Score = 78.6 bits (192), Expect = 1e-14
Identities = 65/274 (23%), Positives = 138/274 (50%), Gaps = 14/274 (5%)
Query: 57 DEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGES 116
D+E + KK +EQE + +QEE + R+R + ++ E+ E + K+ E E E
Sbjct: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQE---EK 618
Query: 117 DSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSG 176
E E W E+E+ +E+EE++ ++E + + Q+R E+ E + E
Sbjct: 619 MQEQEEKMW--EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW---EHEKM 673
Query: 177 EESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKEL--EQEAKRMAE 234
+E E E EE +++ME + + + D+ ++E E+ ++K++ E+E R E
Sbjct: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Query: 235 ERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAW---KVRELKRI-KRD 290
E+ + + ++E+ ++ E+ ++ + + E++ + W K++E ++I +++
Sbjct: 734 EKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE 793
Query: 291 REDREALEKEKAEIERMRNLTEEERRAELRANGK 324
+ R+ EK + + E+MR E+ R E + G+
Sbjct: 794 EKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQ 827
Score = 77.8 bits (190), Expect = 2e-14
Identities = 67/274 (24%), Positives = 134/274 (48%), Gaps = 15/274 (5%)
Query: 54 DEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVV 113
++E++ ++ +K +EQE + EQEE Q R+ E +E+L H K+ E E +
Sbjct: 621 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQ-KEKLWEHEKMQEQEKM 679
Query: 114 GESDSEVEGDAWRMER-EDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDE 172
E + ++ W E+ E ++E+E++ D+E R MR+R +++ EE E+M ++E
Sbjct: 680 QEQEEKI----WEQEKMEKKTQEQEKKTWDQEKMREEESMRER-EKKMREEEEMMREQEE 734
Query: 173 GRSGEESESESEYEEYTDSEDEMEPRLKPVFIR-----KKDRVTVQEREAEALKQKELEQ 227
+E + + + EE + E++M + + ++ + +K+++ E+ E K E E+
Sbjct: 735 KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEE 794
Query: 228 EAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRI 287
+ + E+ R K+ +E K +E K +++ +E + W E
Sbjct: 795 KMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEE 854
Query: 288 K---RDREDREALEKEKAEIERMRNLTEEERRAE 318
K ++ + RE EK + + E+MR E+ R E
Sbjct: 855 KMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQE 888
Score = 70.5 bits (171), Expect = 3e-12
Identities = 63/292 (21%), Positives = 143/292 (48%), Gaps = 29/292 (9%)
Query: 51 ESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERL--------A 102
+ ++E++ ++ +K +EQE + QEE + R Q + D EER+
Sbjct: 349 QMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLRE 408
Query: 103 RHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEE-IERRRGMMRQRAQERKN 161
+ ++ E E + E ++ + E+E + ++EE++ +EE I R MR+ + +
Sbjct: 409 KEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMRE 468
Query: 162 EEMEVMEVEDEGRSGEESESES----EYEEYTDSEDEMEPRLKPVF-----IRKKDRVTV 212
+E ++ + E+ EE E + E +E +++M+ + + ++ IR ++ +
Sbjct: 469 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 528
Query: 213 QERE---AEALKQKE---LEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALN 266
QE++ E ++++E EQE K +E++ + + E KK E+ K++ + +
Sbjct: 529 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQE--ERMEKKTQEQEKKTWDQEEKMR 586
Query: 267 TDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAE 318
++ E E K+RE + + R++E++ ++EK + + + +EE+ E
Sbjct: 587 EEERMREREK---KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQE 635
Score = 68.2 bits (165), Expect = 1e-11
Identities = 66/310 (21%), Positives = 141/310 (45%), Gaps = 23/310 (7%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEE------ 75
+R+++ EK ++ ++ D + D+E + + + E + +E
Sbjct: 520 IRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTW 579
Query: 76 -QEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSE 134
QEE + R+R + ++ E+ E + K+ E E E E E W E+E+ +
Sbjct: 580 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQE---EKMQEQEEKMW--EQEEKMQ 634
Query: 135 EEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDE 194
E+EE++ ++E + + Q+R E+ E + E +E E E EE +++
Sbjct: 635 EQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW---EHEKMQEQEKMQEQEEKIWEQEK 691
Query: 195 MEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEE 254
ME + + + D+ ++E E+ ++K++ +E + M E+ K ++E+ +K E+
Sbjct: 692 MEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEK-----MQEQEEKMQEQ 746
Query: 255 NKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEE 314
+ + + E +E+ +E ++ E K + E + EK + E+MR+ E+
Sbjct: 747 EEEMWEQEEKM---WEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKM 803
Query: 315 RRAELRANGK 324
R E + G+
Sbjct: 804 RGQEEKMRGQ 813
Score = 62.0 bits (149), Expect = 1e-09
Identities = 76/322 (23%), Positives = 151/322 (46%), Gaps = 59/322 (18%)
Query: 13 IQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPME--SSDEEDEEFQFIKKAKEQE 70
+Q AV R++K + +E++ +R D +E + +EE + K A+ QE
Sbjct: 181 LQRALSAVSTRHKKADRYIEELTKER-------DALSLELYRNTITNEELKK-KNAELQE 232
Query: 71 AEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMERE 130
P + E S ++ L+ ++ K + P+V + ++ + WR E E
Sbjct: 233 KLPLAESEKSEIQLNVKELKRKLER---------AKFLLPQV---QTNTLQEEMWRQEEE 280
Query: 131 DSSEE-----EEEEI--DDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESES 183
+E +EE++ +E + + G MR++ ++ +E + E E E R E+ +
Sbjct: 281 LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELR--EQEKELR 338
Query: 184 EYEEYTDSEDEMEPRLKPVFIRKKDRVTVQE----REAEALKQKE---LEQEAKRMAEER 236
E +E + E++M+ + + ++ +++++ QE R+ E L ++E EQE K +E
Sbjct: 339 EQKELREQEEQMQEQEEKMW-EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Query: 237 RKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRI----KRDRE 292
R + ++E +E EE R + E E+ E K+RE K++ K+ R+
Sbjct: 398 RMWE----QDERLREKEERMR----------EQEKMWEQVE--KMREEKKMQEQEKKTRD 441
Query: 293 DREALEKEKAEIERMRNLTEEE 314
E +++E+ ER + + EEE
Sbjct: 442 QEEKMQEEERIREREKKMREEE 463
Score = 60.1 bits (144), Expect = 4e-09
Identities = 48/216 (22%), Positives = 100/216 (46%), Gaps = 5/216 (2%)
Query: 25 EKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEED-SSSD 83
E+ E E+ K+++ + E EE+ + KK +E+E EQEE +
Sbjct: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQE 740
Query: 84 PRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDE 143
+++ + + E E+ + K+ E + + E ++ E+E E+EE+ D E
Sbjct: 741 EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQE 800
Query: 144 EIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVF 203
E R + + +E+ + E M ++E G+E + + E+ E++ME +++
Sbjct: 801 EKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQ--- 857
Query: 204 IRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKY 239
+++++ QE + ++K EQE K +E + Y
Sbjct: 858 -GQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIY 892
Score = 54.3 bits (129), Expect = 2e-07
Identities = 53/232 (22%), Positives = 110/232 (47%), Gaps = 15/232 (6%)
Query: 35 KVKRYVSGKRPDYAPMESSDEED-EEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRI 93
K K + K + M+ +E+ E+ + KK +EQE + +QE+ + +R + ++
Sbjct: 664 KEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEK-MREEESMREREKKM 722
Query: 94 SEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEE---EEEIDDEEIERRRG 150
E+ E + K+ E E E E E + W E + +EE E++ E+ E+
Sbjct: 723 REEEEMMREQEEKMQEQE---EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 779
Query: 151 MMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIR----- 205
+ + QE+ E+ E M ++E G+E + + E+ E++M + + ++ +
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMW 839
Query: 206 -KKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENK 256
+++++ QE + E K + E++ + E+ R K+ E+E K +E K
Sbjct: 840 GQEEKMWGQEEKMEE-KMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
Score = 49.7 bits (117), Expect = 5e-06
Identities = 44/197 (22%), Positives = 94/197 (47%), Gaps = 20/197 (10%)
Query: 132 SSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEV-MEVEDEGRSGEES-------ESES 183
S E I +EE++++ ++++ ++E+ E+ + V++ R E + ++ +
Sbjct: 210 SLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNT 269
Query: 184 EYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKI 243
EE E+E+ + K + ++++++ QE + K EQE K +E+R
Sbjct: 270 LQEEMWRQEEELREQEKKIR-KQEEKMWRQEERLREQEGKMREQEEKMWRQEKRL----- 323
Query: 244 VEEETKKELEENKRSLAALDALNTDDEN-DEEEYEAWKVRELKRIKRD---REDREALEK 299
E +KEL E ++ L L +E E+E + W+ E R + + R++ E+
Sbjct: 324 --REQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 381
Query: 300 EKAEIERMRNLTEEERR 316
EK E+ + + ++E R
Sbjct: 382 EKQMREQEQKMRDQEER 398
Score = 34.3 bits (77), Expect = 0.23
Identities = 38/186 (20%), Positives = 79/186 (42%), Gaps = 22/186 (11%)
Query: 144 EIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVF 203
E++R + R ++ + +E + E + S E + EE E++ +L P+
Sbjct: 180 ELQRALSAVSTR-HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKL-PLA 237
Query: 204 IRKKDRVTVQEREAEA-----------LKQKELEQEAKRMAEERRKYTLKIVEEETKKEL 252
+K + + +E + ++ L++E R EE R+ KI ++E K
Sbjct: 238 ESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR 297
Query: 253 EENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTE 312
+E + + + E+E + W R+ KR++ ++ EKE E + +R E
Sbjct: 298 QEERLR-------EQEGKMREQEEKMW--RQEKRLREQEKELREQEKELREQKELREQEE 348
Query: 313 EERRAE 318
+ + E
Sbjct: 349 QMQEQE 354
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 81.3 bits (199), Expect = 2e-15
Identities = 75/336 (22%), Positives = 148/336 (44%), Gaps = 44/336 (13%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSS 81
+R ++G++ ++ K++R R + E+++E + KK +EQE + +EQEE
Sbjct: 264 LREQEGKMREQEEKMRRQEKRLREQEKELR---EQEKELREQKKLREQEEQMQEQEEKMW 320
Query: 82 SDPRLRRLQNRISEDVEERLARHRKIV---------EPEVVGESDSEVEGDAWRMEREDS 132
R Q EERL K + + E + E D + RM ++
Sbjct: 321 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK 380
Query: 133 SEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEG------------------- 173
E+EE++ +EE R R + +E E+ E M+ ++E
Sbjct: 381 MWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKE 440
Query: 174 ------RSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQ 227
+ E+ E E EE ++EM + K ++ +++++ QE + ++K +Q
Sbjct: 441 KLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMW--RQEKMREQEDQMWEQEEKMRDQ 498
Query: 228 EAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAW----KVRE 283
E K +E R + E ++ + E K+ + + + + E+E + W K+RE
Sbjct: 499 EQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMRE 558
Query: 284 LKRIK-RDREDREALEKEKAEIERMRNLTEEERRAE 318
+R++ R+++ RE E + + E+M+ E+ R E
Sbjct: 559 EERMREREKKMREEEEMMREQEEKMQEQEEKMREQE 594
Score = 79.3 bits (194), Expect = 6e-15
Identities = 67/271 (24%), Positives = 131/271 (48%), Gaps = 19/271 (7%)
Query: 55 EEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVG 114
+E++ ++ ++ +EQE + EQEE + R Q + + E+ L +K+ E E
Sbjct: 253 QEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQE--- 309
Query: 115 ESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGR 174
E E E W E + +EE+ +E + + MR++ Q+ +++E + E ++ R
Sbjct: 310 EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLR 369
Query: 175 SGEESESES----EYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKE--LEQE 228
EE E E EE E+ + R K + +++ T++E+E + KQ+E EQE
Sbjct: 370 EKEERMREQEKMWEQEEKMQEEERIREREKKM---REEEETMREQEEKMQKQEENMWEQE 426
Query: 229 AKRMAEER-RKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRI 287
K ++R + K+ E+E +E EE + + + +E +E + W+ ++
Sbjct: 427 EKEWQQQRLPEQKEKLWEQEKMQEQEE--KIWEQEEKIRDQEEMWGQEKKMWRQEKM--- 481
Query: 288 KRDREDREALEKEKAEIERMRNLTEEERRAE 318
R++ED+ ++EK + + +EER E
Sbjct: 482 -REQEDQMWEQEEKMRDQEQKMWDQEERMWE 511
Score = 76.6 bits (187), Expect = 4e-14
Identities = 72/274 (26%), Positives = 124/274 (45%), Gaps = 19/274 (6%)
Query: 54 DEEDEEFQFIKKAKEQEAEPEEQEEDS-SSDPRLRRLQNRISE-----DVEERLARHRKI 107
++ED+ ++ +K ++QE + +QEE D RLR + R+ E EE++ +K
Sbjct: 483 EQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKT 542
Query: 108 VEPEVVGESDSEVEGDAWRM-EREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEV 166
E E E + RM ERE EEEE + ++E + + + R QE K E E
Sbjct: 543 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEE 602
Query: 167 MEVEDEGRSGEESES--ESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKE 224
E E + E+ E E E E+ ++EM + +++++ QE + ++K
Sbjct: 603 KMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKM 662
Query: 225 LEQEAKRMAEER--RKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVR 282
EQE K +E R+ K+ +E K +E K +++ +E + W
Sbjct: 663 REQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQE 722
Query: 283 ELKRIKRDREDREALEKEKAEIERMRNLTEEERR 316
E+ R++E+R +KEK + L E E R
Sbjct: 723 EM----REKEERIRDQKEKMQ----ERLPEHEER 748
Score = 73.9 bits (180), Expect = 3e-13
Identities = 60/277 (21%), Positives = 134/277 (48%), Gaps = 23/277 (8%)
Query: 55 EEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVG 114
E+DE + ++ ++ + EQEE + R+R + ++ E+ E + K+ + E
Sbjct: 363 EQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE--- 419
Query: 115 ESDSEVEGDAWRMER----------EDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEM 164
E+ E E W+ +R ++ +E+EE+I ++E E+ R QE+K
Sbjct: 420 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE-EKIRDQEEMWGQEKKMWRQ 478
Query: 165 EVMEVEDEGRSGEESESESEYEEYTDSEDEM---EPRLKPVFIRKKDRVTVQEREAEALK 221
E M +++ +E + + ++ D E+ M + RL+ R +++ + ++E + +
Sbjct: 479 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMRE 538
Query: 222 QKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKV 281
+K+ +++ K+ ++ K+ EEE +E E+ R + + +E +E+ E +
Sbjct: 539 EKKTQEQEKKTWDQEE----KMREEERMREREKKMRE--EEEMMREQEEKMQEQEEKMRE 592
Query: 282 RELKRIKRDREDREALEKEKAEIERMRNLTEEERRAE 318
+E K +++ + +E EK + E+M EE++ E
Sbjct: 593 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQE 629
Score = 73.9 bits (180), Expect = 3e-13
Identities = 70/300 (23%), Positives = 136/300 (45%), Gaps = 20/300 (6%)
Query: 32 EKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQN 91
EK++ + + + E + E EE K ++QE EQEE RL +
Sbjct: 386 EKMQEEERIREREKKMREEEETMREQEE-----KMQKQEENMWEQEEKEWQQQRLPEQKE 440
Query: 92 RISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGM 151
++ E E+ + KI E E E+ G +M R++ E+E+++ ++E
Sbjct: 441 KLWEQ-EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE------- 492
Query: 152 MRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKK---- 207
+ R QE+K + E E + R E+ E E ++ E++M K KK
Sbjct: 493 EKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQ 552
Query: 208 -DRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALN 266
+++ +ER E K+ E+E R EE+ + + + E+ +K E+ ++ + +
Sbjct: 553 EEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMW 612
Query: 267 TDDENDEEEYEAWKVRELKRIKRDREDREALEKEK--AEIERMRNLTEEERRAELRANGK 324
+E E+ E K++E + + ++E++ ++EK + E+MR E+ R E + G+
Sbjct: 613 EQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQ 672
Score = 70.5 bits (171), Expect = 3e-12
Identities = 61/246 (24%), Positives = 115/246 (46%), Gaps = 22/246 (8%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGD 123
+K +EQE + EQEE ++R + ++ + E + ++ E E ++
Sbjct: 479 EKMREQEDQMWEQEE------KMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQ 532
Query: 124 AWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESES 183
+M E ++E+E++ D+E E+ R R R +E+K E E M E E + E+ E
Sbjct: 533 EEKMREEKKTQEQEKKTWDQE-EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMR 591
Query: 184 EYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKEL--EQEAKRMAEERRKYTL 241
E EE ++E + +++++ QE E + +Q+E+ EQE K +E + +
Sbjct: 592 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWE- 650
Query: 242 KIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEK 301
+EE +E EE R +E + + E + +E K ++ + RE EK +
Sbjct: 651 ---QEEKMREQEEKMRE---------QEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMR 698
Query: 302 AEIERM 307
+ E+M
Sbjct: 699 GQEEKM 704
Score = 61.6 bits (148), Expect = 1e-09
Identities = 65/273 (23%), Positives = 120/273 (43%), Gaps = 28/273 (10%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISE------DVEERLARHRKIVEPEVVGESD 117
K A+ QE + E S ++ L+ ++ V+ + + E + E +
Sbjct: 188 KNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQE 247
Query: 118 SEVEGDAWRMER-EDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSG 176
++ +M R E+ E+E ++ ++E + RR R R QE++ E E E+ ++ +
Sbjct: 248 KKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQE-KELREQKKLR 306
Query: 177 EESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAK------ 230
E+ E E EE ++E + R+++R+ QE++ +QK +QE +
Sbjct: 307 EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDE 366
Query: 231 --RMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIK 288
R EER + K+ E+E K + EE R ++ EE E + +E K K
Sbjct: 367 RLREKEERMREQEKMWEQEEKMQEEERIRE---------REKKMREEEETMREQEEKMQK 417
Query: 289 RDREDREALEKEKAE---IERMRNLTEEERRAE 318
++ E EKE + E+ L E+E+ E
Sbjct: 418 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE 450
Score = 56.6 bits (135), Expect = 4e-08
Identities = 66/267 (24%), Positives = 126/267 (47%), Gaps = 21/267 (7%)
Query: 67 KEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWR 126
KE++A E ++ ++ L++ + E + RLA K V E ++E +
Sbjct: 166 KERDALSLELYRNTITNEELKKKNAELQEKL--RLAESEKSEIQLNVKELKRKLERAKFL 223
Query: 127 MEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYE 186
+ + ++ +EE EE E R + R QE K E E EG+ E+ E E
Sbjct: 224 LPQVQTNTLQEEMWRQEE-ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQE 282
Query: 187 EYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAK-RMAEE---RRKYTL- 241
+ E E E R + +R++ ++ QE + + ++K EQE K R EE R++ L
Sbjct: 283 KRL-REQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 341
Query: 242 ---KIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAW----KVRELKRI----KRD 290
K + E+ +K ++ +R + L +E E+ + W K++E +RI K+
Sbjct: 342 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKM 401
Query: 291 REDREALEKEKAEIERM-RNLTEEERR 316
RE+ E + +++ ++++ N+ E+E +
Sbjct: 402 REEEETMREQEEKMQKQEENMWEQEEK 428
Score = 51.2 bits (121), Expect = 2e-06
Identities = 50/199 (25%), Positives = 93/199 (46%), Gaps = 17/199 (8%)
Query: 51 ESSDEEDEEFQFIKKAKEQEAEPEEQEED-SSSDPRLRRLQNRISEDVEERLARHRKIVE 109
E EE+ + KK +E+E EQEE + ++R + ++ E E+ + K+ E
Sbjct: 554 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWE 613
Query: 110 PEVV----GESDS--EVEGDAWRME-----REDSSEEEEEEIDDEEIERRRGMMRQRAQE 158
E E D E E W E +E+ E+EE++ ++E + R + + QE
Sbjct: 614 QEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQE 673
Query: 159 RK-NEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREA 217
K E+ E M+ ++E +E + + E+ E++M + + ++ +++ ++E+E
Sbjct: 674 EKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE----MREKEE 729
Query: 218 EALKQKELEQEAKRMAEER 236
QKE QE EER
Sbjct: 730 RIRDQKEKMQERLPEHEER 748
Score = 49.3 bits (116), Expect = 7e-06
Identities = 58/255 (22%), Positives = 107/255 (41%), Gaps = 31/255 (12%)
Query: 87 RRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEI- 145
++ I E +ER A ++ + E + + R SE+ E +++ +E+
Sbjct: 155 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELK 214
Query: 146 ---ERRRGMMRQRAQERKNEEM-----EVMEVEDEGRSGEES--ESESEYEEYTDSEDEM 195
ER + ++ Q EEM E+ E E + R EE E E E
Sbjct: 215 RKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ 274
Query: 196 EPRLKPVFIRKKDRVTVQER-----EAEALKQKELEQEAKRMAEERRK---YTLKIVEEE 247
E +++ R++ R+ QE+ E E +QK+L ++ ++M E+ K K+ E+E
Sbjct: 275 EEKMR----RQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQE 330
Query: 248 TKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDR--------EDREALEK 299
K +E + + + ++E W+ E R K +R E E +++
Sbjct: 331 EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQE 390
Query: 300 EKAEIERMRNLTEEE 314
E+ ER + + EEE
Sbjct: 391 EERIREREKKMREEE 405
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 80.5 bits (197), Expect = 3e-15
Identities = 99/440 (22%), Positives = 195/440 (44%), Gaps = 62/440 (14%)
Query: 11 PPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFI--KKAKE 68
P I + ++P R + + + + K S R + +E ++ + +Q + A+E
Sbjct: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEE 182
Query: 69 QEAEPEEQEEDSSSDPRLRRL-QNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRM 127
+ E +E+EE+ P+ + +N++ VEE+ ++ E V+ + ++ + +
Sbjct: 183 NKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQE--ETVVMSLKNGQISSEEPKQ 240
Query: 128 EREDSSEEEEEEI---------DDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEE 178
E E E+ +EI D E E R + +ER E + ++ DE R+ E
Sbjct: 241 EEE--REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQD-KKIADE-RARIE 296
Query: 179 SESESEYEEYTDSEDEMEPRLKPVFIR-KKDRVTVQEREAEALKQKE-LEQEAKRMAEER 236
+E ++ +E E E R++ R ++R ++E E A ++++ +++E KR AEER
Sbjct: 297 AEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEER 356
Query: 237 RKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREA 296
++ ++EE K+ EE +R+ A EE E KV E KR K+ E + A
Sbjct: 357 QR-----IKEEEKRAAEERQRARA-------------EEEEKAKVEEQKRNKQLEEKKHA 398
Query: 297 LEKEKAEIERMRNLTEEERRAELRANGKVITNKAVK--GKYKFLQKYYHRGAFFMDEDEE 354
+++ K + E++ E + E +A + +K G+ K + R + ED+
Sbjct: 399 MQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREK--LQEDKP 456
Query: 355 VYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDTTSFDSAWGQESAQNT 414
+K++ ++ K PK +VK+F +D+ + + +QN
Sbjct: 457 TFKKE---EIKDEKIKKDKEPK-EEVKSF-----------MDR-----KKGFTEVKSQNG 496
Query: 415 KFFKQKAAGVRDVFERPSAK 434
+F K + F RP +
Sbjct: 497 EFMTHKLKHTENTFSRPGGR 516
Score = 74.3 bits (181), Expect = 2e-13
Identities = 73/294 (24%), Positives = 135/294 (45%), Gaps = 32/294 (10%)
Query: 56 EDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISE----DVEERLARHRKIVEPE 111
E+ + +++A E++ E + D+S RR+QN +E + EE+ ++ E E
Sbjct: 104 EERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE 163
Query: 112 VVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGM-------MRQRAQERKNEEM 164
+ + WR E+ E++E+E ++EE +R + M + EE
Sbjct: 164 ETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEET 223
Query: 165 EVMEVEDEGRSGEESESESEYEEYTDS---EDEMEPRLKPVFIRKKDRVTVQEREA-EAL 220
VM +++ S EE + E E E+ +D ++ME K ++ R+ +ERE +A
Sbjct: 224 VVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAE 283
Query: 221 KQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWK 280
+ K++ E R+ E + +E ++E EE +R + +++ EE + K
Sbjct: 284 QDKKIADERARIEAEEKA----AAQERERREAEERER-------MREEEKRAAEERQRIK 332
Query: 281 VRELKRIKRDREDREALEKE--KAEIERMRNLTEEERRAELRANGKVITNKAVK 332
E KR E+R+ +++E +A ER R EE+R AE R + + K
Sbjct: 333 EEE----KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAK 382
Score = 67.8 bits (164), Expect = 2e-11
Identities = 80/334 (23%), Positives = 147/334 (44%), Gaps = 53/334 (15%)
Query: 7 LMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKA 66
++++ +S V + + G+IS E+ K + + + E +EED+E +A
Sbjct: 211 MVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKE-----RA 265
Query: 67 KEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWR 126
+ + A E +E + RI + ++++A R + E E A
Sbjct: 266 EAERARLEAEERE------------RIKAEQDKKIADERARI----------EAEEKAAA 303
Query: 127 MEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYE 186
ERE EE E + +EE R + +E++ E E+E R+ EE + E E
Sbjct: 304 QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKE-E 362
Query: 187 EYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEE-RRKYTLKIVE 245
E +E+ R + +K +V Q+R + ++K QE K E+ +K K V
Sbjct: 363 EKRAAEERQRARAEE---EEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVN 419
Query: 246 EETKKELEENKRSLAAL--------DALNTDDENDEEEYEAWKVRELK--RIKRDREDRE 295
E K+ +E+K A L + E +E+ +K E+K +IK+D+E +E
Sbjct: 420 E---KKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKE 476
Query: 296 ALEKEKAEIERMRNLTEEERRAELRANGKVITNK 329
+ K+ ++R + TE + + NG+ +T+K
Sbjct: 477 EV---KSFMDRKKGFTEVKSQ-----NGEFMTHK 502
Score = 65.9 bits (159), Expect = 7e-11
Identities = 73/285 (25%), Positives = 127/285 (44%), Gaps = 30/285 (10%)
Query: 75 EQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDS----EVEGDAWR---M 127
E +++++ RL R + R + ++E L R ++ +P + S S ++ D
Sbjct: 89 EGDDEAAFLERLARREERRQKRLQEALERQKEF-DPTITDASLSLPSRRMQNDTAENETT 147
Query: 128 EREDSSEEEEEEIDDEEIERRRGMMRQR----AQERKNEEMEVMEVEDE----GRSGEES 179
E+E+ SE +E + EE E ++ A+E K E+ E E E+E G GE
Sbjct: 148 EKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQ 207
Query: 180 ESESEYEEYTDSEDE-MEPRLKPVFIRKKDRVTVQEREA---EALKQKELEQEAKRMAEE 235
E+ T+S++E + LK I ++ +ERE E +++E+E K AE
Sbjct: 208 VEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEA 267
Query: 236 RRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDRE 295
R + E EE +R A D D+ E E +E +R + + +R
Sbjct: 268 ER----------ARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERM 317
Query: 296 ALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQK 340
E+++A ER R EE+R AE R K +A + + + ++
Sbjct: 318 REEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEE 362
Score = 58.9 bits (141), Expect = 9e-09
Identities = 76/320 (23%), Positives = 137/320 (42%), Gaps = 55/320 (17%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEED---EEFQFIKKAKEQEAEPEEQEE 78
++ E+ + E+ ++K KR +EE EE Q + +E++A+ EEQ+
Sbjct: 331 IKEEEKRAAEERQRIKE--EEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKR 388
Query: 79 DSSSDPRLRRLQN------RISEDVEERLARHRKIVEPEV---VGESDSEVEGDAWRMER 129
+ + + +Q ++ + +E + +K E ++ V + E +G + +R
Sbjct: 389 NKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKR 448
Query: 130 EDSSEEE----EEEIDDEEIERRRGMMRQRAQERKNEEMEVME-----VEDEGRSGEESE 180
E E++ +EEI DE+I++ + E K E M+ E + ++GE
Sbjct: 449 EKLQEDKPTFKKEEIKDEKIKKDK--------EPKEEVKSFMDRKKGFTEVKSQNGEFMT 500
Query: 181 SESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYT 240
+ ++ E T F R R +V +EAE Q E A + EE R+
Sbjct: 501 HKLKHTENT-------------FSRPGGRASVDTKEAEGAPQVE----AGKRLEELRRRR 543
Query: 241 LKIVEEETKKELEENKRSLAALDALNTDDEND----EEEYEAWKVRELKRIKRDREDREA 296
+ EE +K ++ + + L+ L E EEE + K E R R+ E++
Sbjct: 544 GETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRR 603
Query: 297 LEKEKAEIERMRNLTEEERR 316
L K EIER R E+R+
Sbjct: 604 L---KEEIERRRAEAAEKRQ 620
Score = 42.4 bits (98), Expect = 8e-04
Identities = 47/263 (17%), Positives = 107/263 (40%), Gaps = 22/263 (8%)
Query: 111 EVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVE 170
E+ + E+ +A R+ + + ++EEE + R+ +RQ K EE + +V
Sbjct: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQ-----KQEEESLGQVT 63
Query: 171 DEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAK 230
D+ ++ E + T + ++E + F+ + R E +QK L++ +
Sbjct: 64 DQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLAR-------REERRQKRLQEALE 116
Query: 231 RMAEERRKYT---LKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRI 287
R E T L + + + EN+ + E+ +E YE + + +
Sbjct: 117 RQKEFDPTITDASLSLPSRRMQNDTAENETT-----EKEEKSESRQERYEIEETETVTKS 171
Query: 288 KRDREDREALEKEKAEIERMRNLTEEERRAELRAN--GKVITNKAVKGKYKFLQKYYHRG 345
+ + R+A E +K + E+ E+ +R + N ++ K + + + + G
Sbjct: 172 YQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNG 231
Query: 346 AFFMDEDEEVYKRDFSAPTLEDH 368
+E ++ +R+ + + H
Sbjct: 232 QISSEEPKQEEEREQGSDEISHH 254
Score = 30.0 bits (66), Expect = 4.3
Identities = 37/149 (24%), Positives = 63/149 (42%), Gaps = 23/149 (15%)
Query: 69 QEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRME 128
+EAE Q E LRR + + E+L + ++ E+ E+E E
Sbjct: 522 KEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQ--------EAALELE------E 567
Query: 129 REDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEY 188
+ EE + +++E E+RR + R+ EE ++ E E R E +E + E
Sbjct: 568 LKKKREERRKVLEEE--EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 625
Query: 189 TDSEDEMEPRLKP--VFIRKKDRVTVQER 215
S+D+ KP F K + ++ER
Sbjct: 626 GLSDDK-----KPFKCFTPKGSSLKIEER 649
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 80.1 bits (196), Expect = 4e-15
Identities = 72/290 (24%), Positives = 134/290 (46%), Gaps = 31/290 (10%)
Query: 52 SSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIV--E 109
+ +E++ ++ +K +E+E + +EQEE R Q + + EE++ R +++ +
Sbjct: 283 NQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK 342
Query: 110 PEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMM-----RQRAQERKNEEM 164
E + E + ++ E+E+ +EEE+ + E+ + + M + R QE K E
Sbjct: 343 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 402
Query: 165 EVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQE---REAEALK 221
E M E E + GE+ E E EE ++E R + ++ ++ QE RE E +
Sbjct: 403 EEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 462
Query: 222 QKE-----------LEQEAKRMAEER--RKYTLKIVEEETKKELEENKRSLAALDALNTD 268
Q++ EQEAK +E R+ KI E+E K +E K +
Sbjct: 463 QEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEK--------IREQ 514
Query: 269 DENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAE 318
+E +E+ E +E K +++ + +E EK + + E+MR R+ E
Sbjct: 515 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQE 564
Score = 70.9 bits (172), Expect = 2e-12
Identities = 55/207 (26%), Positives = 105/207 (50%), Gaps = 10/207 (4%)
Query: 50 MESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVE 109
+E E E+ + ++ +++E + EQE+ + ++ R + +I E E+ + + E
Sbjct: 349 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQE 408
Query: 110 PEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV 169
E E E E W E+E+ +E+EE++ +E + R + R QE K E E M
Sbjct: 409 QE---EKMGEQEEKMW--EQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ 463
Query: 170 EDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEA 229
E E + GE+ E +E E E + R + IR++++ ++E+E + +Q+E+ QE
Sbjct: 464 EQEEKMGEQEGKMCE-QEAKMQEQEEKMRRQEEKIREQEK-KIREQEEKIREQEEMMQEQ 521
Query: 230 KRMAEERRKYTLKIVEEETKKELEENK 256
+ E+ + K+ E+E K + +E K
Sbjct: 522 EEKMWEQEE---KMCEQEEKMQEQEEK 545
Score = 63.9 bits (154), Expect = 3e-10
Identities = 54/276 (19%), Positives = 125/276 (45%), Gaps = 9/276 (3%)
Query: 23 RNEKGEISMEKVKVKRYVSGKRPDYA-PMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSS 81
R EK + EK++ + ++ + E EE + K+ K +E E + E++
Sbjct: 300 REEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKI 359
Query: 82 SDPRLRRLQNRISEDVEERLARHRKIV-EPEVVGESDSEVEGDAWRMEREDSSEEEEEEI 140
+ +R + + E+R + K+ + E + E + ++ E+E+ +E+EE++
Sbjct: 360 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR------EQEEMMQEQEEKM 413
Query: 141 DDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLK 200
++E + + QE K E E E + E+ E E EE ++E +
Sbjct: 414 GEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQE 473
Query: 201 PVFIRKKDRVTVQEREAEALKQKELEQEAK-RMAEERRKYTLKIVEEETKKELEENKRSL 259
++ ++ QE + ++K EQE K R EE+ + ++++E+ +K E+ ++
Sbjct: 474 GKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC 533
Query: 260 AALDALNTDDENDEEEYEAWKVRELKRIKRDREDRE 295
+ + +E + E + +E++ +++ + +E
Sbjct: 534 EQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 58.5 bits (140), Expect = 1e-08
Identities = 67/309 (21%), Positives = 133/309 (43%), Gaps = 47/309 (15%)
Query: 29 ISMEKVKVKRYVSG--KRPDYAPMES-----SDEEDEEFQFIKKAKEQEAEPEEQEEDSS 81
++ +K K RY+ K D +E +DEE +E K AK QE + E S
Sbjct: 172 VATQKKKADRYIEELTKERDALSLELYRNTITDEELKE----KNAKLQEKLQLVESEKSE 227
Query: 82 SDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEID 141
++ L+ ++ K++ P+ + E D E + S + + +++
Sbjct: 228 IQLNVKELKRKLER---------AKLLLPQ----QQLQAEADHLGKELQSVSAKLQAQVE 274
Query: 142 DEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKP 201
+ E+ R ++ R+ E+++ E E E EE ++E R +
Sbjct: 275 ENELWNRLNQQQEEKMWRQEEKIQ-----------EREEKIQEQEEKIREQEEKMRRQEE 323
Query: 202 VFIRKKDRVTVQ-------EREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELE- 253
+ K++++ Q E + L++K EQE R EE+R+ KI E+E ++E E
Sbjct: 324 MMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 383
Query: 254 ----ENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRN 309
+ ++ + + +E +E+ E +E K +++ E +E EK + + E++R
Sbjct: 384 KMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIRE 443
Query: 310 LTEEERRAE 318
++ R E
Sbjct: 444 QEKKIREQE 452
Score = 48.1 bits (113), Expect = 2e-05
Identities = 45/195 (23%), Positives = 91/195 (46%), Gaps = 10/195 (5%)
Query: 132 SSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEV-MEVEDEGRSGEESESESEYEEYTD 190
S E I DEE++ + ++++ Q ++E+ E+ + V++ R E ++ ++
Sbjct: 194 SLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA 253
Query: 191 SEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKK 250
D + L+ V K + V+E E ++ E++ R E+ ++ KI E+E K
Sbjct: 254 EADHLGKELQSV--SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKI 311
Query: 251 ELEENKRSLAALDALNTDDENDEEEYEAW----KVRELKRIKRDREDREALEKEKAEIER 306
+E K +++ +E W K+REL+ ++E E+++ E E+
Sbjct: 312 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 371
Query: 307 MRNLTEEERRAELRA 321
+R E+E+R E A
Sbjct: 372 IR---EQEKRQEQEA 383
Score = 39.3 bits (90), Expect = 0.007
Identities = 37/164 (22%), Positives = 72/164 (43%), Gaps = 27/164 (16%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSS 81
+R ++ +I ++ K++ R M+ +E+ E + K EQEA+ +EQEE
Sbjct: 434 MRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQE--GKMCEQEAKMQEQEE--- 488
Query: 82 SDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEID 141
++RR + +I E ++ + KI E+E+ +E+EE++
Sbjct: 489 ---KMRRQEEKIREQEKKIREQEEKI-------------------REQEEMMQEQEEKMW 526
Query: 142 DEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEY 185
++E + + + QE K E E E R ++ E E+
Sbjct: 527 EQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570
Score = 32.7 bits (73), Expect = 0.67
Identities = 36/203 (17%), Positives = 87/203 (42%), Gaps = 16/203 (7%)
Query: 123 DAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESE 182
D+W+ + E E+ + ++++ R E +E + + +E + + E +
Sbjct: 157 DSWKF-----AGELEQALSAVATQKKKA---DRYIEELTKERDALSLELYRNTITDEELK 208
Query: 183 SEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLK 242
+ + + +E + + K+ ER L Q++L+ EA + +E + + K
Sbjct: 209 EKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 268
Query: 243 IVEEETKKEL------EENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREA 296
+ + + EL ++ ++ + + +E +E+ E K+RE + R +E+
Sbjct: 269 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEE--KIREQEEKMRRQEEMMW 326
Query: 297 LEKEKAEIERMRNLTEEERRAEL 319
++EK + +EE+ EL
Sbjct: 327 EKEEKMRRQEEMMWEKEEKIREL 349
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 79.3 bits (194), Expect = 6e-15
Identities = 89/407 (21%), Positives = 184/407 (45%), Gaps = 50/407 (12%)
Query: 14 QSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEP 73
+ T P N + E + K K K+ GK+ + +S + ED++ + K AK +
Sbjct: 76 RETVAVKPTENNEEEFT-SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMY 134
Query: 74 EEQEEDSSSDPRLRRLQ------NRISEDVEERLARHRKIVEPEVVGES-DSEVEGDAWR 126
++D + ++ + N+ + EE +KI E + S +S E D +
Sbjct: 135 SGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFL 194
Query: 127 MER---------------EDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEE---MEVME 168
R E +E+++ + + +++ ++R +++++EE + ++
Sbjct: 195 QSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLK 254
Query: 169 VEDEGRSGE-----ESESESEYEEYT-DSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQ 222
++E +G+ + ES+ ++EE T S+ ++ + P K + T E + E K+
Sbjct: 255 EKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKK 314
Query: 223 KELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVR 282
K+ +++ K EE+ K K + T K ++E AL L ++E + E E +++
Sbjct: 315 KKDKKKKKGEKEEKEKEKKKGPSKATVKAMQE------ALAKLKEEEERQKREEEE-RIK 367
Query: 283 ELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYK---FLQ 339
L+ ++ R++ E LE+EK E ++ + E+ER+ L+ GK++T + + + L+
Sbjct: 368 RLEELEAKRKEEERLEQEKRERKKQK---EKERKERLKKEGKLLTKSQREARARAEATLK 424
Query: 340 KYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRS 386
+G +D KR P ED K I P+ ++ K S
Sbjct: 425 LLQAQGVEVPSKDSLPKKR----PIYEDKKRKKI-PQQLESKEVSES 466
Score = 50.1 bits (118), Expect = 4e-06
Identities = 82/352 (23%), Positives = 143/352 (40%), Gaps = 51/352 (14%)
Query: 23 RNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEED----EEFQFIKKAKEQEAEPEEQEE 78
+ EK E EK K + K A + +EE+ EE + IK+ +E EA+ +E EE
Sbjct: 322 KGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKE-EE 380
Query: 79 DSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEE 138
+ R R+ Q ++ +ERL + K++ E+ + E ++ + ++
Sbjct: 381 RLEQEKRERKKQKE--KERKERLKKEGKLLTKSQ-REARARAEATLKLLQAQGVEVPSKD 437
Query: 139 EIDDE----EIERRRGMMRQRAQERKNEEMEV---MEVEDEG-RSGEESESESEYEEYTD 190
+ + E ++R+ + +Q + +E ME+ +EV ++G EE+ E EE D
Sbjct: 438 SLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEED 497
Query: 191 SEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKK 250
+ED + + + E E ++ ++ E K EE EEE ++
Sbjct: 498 TEDAGLDDWEAM---------ASDEETEKVEGNKVHIEVKENPEEEE-------EEEEEE 541
Query: 251 ELEENKRSLAALDALNTDDENDEE------EYEAWKVRELKRIKRDREDRE--------- 295
E +E + + E DEE E ++ K + K K D E
Sbjct: 542 EEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTK 601
Query: 296 ---ALEKEKAEIERMR-NLTEEERRAELRANGKVITNKAVKGKYKFLQKYYH 343
A +K K IE+ R ++ +LRA + GK K L K H
Sbjct: 602 EERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRH 653
Score = 31.6 bits (70), Expect = 1.5
Identities = 26/109 (23%), Positives = 50/109 (45%), Gaps = 2/109 (1%)
Query: 170 EDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQ-KELEQE 228
ED + + ++ + E + E EP+ K +KK++ E + LK+ +EL E
Sbjct: 10 EDSTKDDIDLDALAAEIEGAGAAKEQEPQ-KSKGKKKKEKKKQDFDEDDILKELEELSLE 68
Query: 229 AKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYE 277
A+ + +R +K E ++ ++K+ + D+ND EE E
Sbjct: 69 AQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELE 117
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 78.2 bits (191), Expect = 1e-14
Identities = 69/291 (23%), Positives = 139/291 (47%), Gaps = 36/291 (12%)
Query: 32 EKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQN 91
EK++ ++ E +E+E+ + +K +EQEA+ QEE ++R +
Sbjct: 438 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE------KIREQEE 491
Query: 92 RISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGM 151
+I E E+ + KI E E + E + R E+E+ +EE+ + EEI R++
Sbjct: 492 KIREQEEKMWRQEEKIHEQEKIREEEK-------RQEQEEMWRQEEKIREQEEIWRQKEK 544
Query: 152 MRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSED--EMEPRLKPVFIRKKDR 209
+ ++ ++ + +E ++ E++ EE E E + + E E E +++ ++++
Sbjct: 545 IHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIR----EQEEK 600
Query: 210 VTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDD 269
+ QE + ++K EQE K +E K+ E+E K +E K + +
Sbjct: 601 IREQEEMTQEQEEKMGEQEEKMCEQEE-----KMQEQEEKMRRQEEK--------IREQE 647
Query: 270 ENDEEEYEAWKVRELKRIKRDREDR--EALEKEKAEIERMRNLTEEERRAE 318
+ E+ E K+RE + + +++E++ E EK + E+M+ E+ RR E
Sbjct: 648 KKIREQEE--KIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 696
Score = 77.8 bits (190), Expect = 2e-14
Identities = 58/270 (21%), Positives = 131/270 (48%), Gaps = 15/270 (5%)
Query: 51 ESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEP 110
E E++E+ Q +K +EQE E++ + + ++R + +I E E+ + KI E
Sbjct: 451 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQ 510
Query: 111 EVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVE 170
E + E + R E+E+ +EE+ + EEI R++ + ++ ++ + +E ++ E
Sbjct: 511 EKIREEEK-------RQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQE 563
Query: 171 DEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAK 230
++ EE E E + + E E K IR+++ ++ E +++++ ++ +
Sbjct: 564 EKMHDQEEKIREQEEKVWRQEEKIREQEEK---IREQEEKIREQEEMTQEQEEKMGEQEE 620
Query: 231 RMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRD 290
+M E+ K ++E+ +K + ++ + +E E+ E + +E K +++
Sbjct: 621 KMCEQEEK-----MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE 675
Query: 291 REDREALEKEKAEIERMRNLTEEERRAELR 320
+ E EK + + E+MR E+ E+R
Sbjct: 676 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVR 705
Score = 67.4 bits (163), Expect = 2e-11
Identities = 79/351 (22%), Positives = 164/351 (46%), Gaps = 31/351 (8%)
Query: 29 ISMEKVKVKRYVSG--KRPDYAPMES-----SDEEDEEFQFIKKAKEQEAEPEEQEEDSS 81
++ +K K RY+ K D +E +DEE +E K AK QE + E S
Sbjct: 245 VATQKKKADRYIEELTKERDALSLELYRNTITDEELKE----KNAKLQEKLQLVESEKSE 300
Query: 82 SDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEV---------EGDAWRMEREDS 132
++ L+ ++ E + L + + E + +G+ V E + W R +
Sbjct: 301 IQLNVKELKRKL-ERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN--RLNQ 357
Query: 133 SEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSE 192
+EE+ +E+I+ ++++ ++ + +E ++ E E++ R EE E E E +
Sbjct: 358 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKE--EKMRRQ 415
Query: 193 DEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKEL 252
+EM + R+++ + +E + L++K EQE R EE+R+ KI E+E ++E
Sbjct: 416 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE- 474
Query: 253 EENKRSLAALDALNTDDENDEEEYEAW----KVRELKRIKRDREDREALEKEKAEIERMR 308
+E K +++ E+E + W K+ E ++I R+ E R+ E+ + E++R
Sbjct: 475 QEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKI-REEEKRQEQEEMWRQEEKIR 533
Query: 309 NLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRD 359
E R+ E + K + ++ +K + + +++E+V++++
Sbjct: 534 EQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQE 584
Score = 66.6 bits (161), Expect = 4e-11
Identities = 71/325 (21%), Positives = 144/325 (44%), Gaps = 39/325 (12%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKR---PDYAPMESSDEEDEEFQFIKKAKEQEAEPEE--- 75
V +EK EI + ++KR + + P +D +E Q + + + E E
Sbjct: 294 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 353
Query: 76 ----QEEDSS--SDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEV---EGDAWR 126
Q+E+ + +++ + +I E E+ + KI E E E+ + + R
Sbjct: 354 RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 413
Query: 127 MEREDSSEEEEEEIDDEEI------------ERRRGMMRQRAQERKNEEMEVMEVEDEGR 174
+ E E+EE+ EE+ E+ + R QE K +E E + E E R
Sbjct: 414 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR-EQEKR 472
Query: 175 SGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELE-----QEA 229
+E++ + E+ + E+++ + + ++ R+++++ QE+ E K++E E +E
Sbjct: 473 QEQEAKMWRQEEKIREQEEKIREQEEKMW-RQEEKIHEQEKIREEEKRQEQEEMWRQEEK 531
Query: 230 KRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKR 289
R EE + KI E+E K +E K + +++ E+E + W+ E +
Sbjct: 532 IREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEE-----K 586
Query: 290 DREDREALEKEKAEIERMRNLTEEE 314
RE E + +++ +I +T+E+
Sbjct: 587 IREQEEKIREQEEKIREQEEMTQEQ 611
Score = 61.6 bits (148), Expect = 1e-09
Identities = 51/244 (20%), Positives = 109/244 (44%), Gaps = 8/244 (3%)
Query: 23 RNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSS 82
+ EK EK++ + ++ + + E+E+ Q ++ QE + EQEE
Sbjct: 482 QEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQ 541
Query: 83 DPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRME-----REDSSEEEE 137
++ + +I + E+ + K+ + E E E E WR E +E+ E+E
Sbjct: 542 KEKIHEQEEKIRKQEEKMWRQEEKMHDQE---EKIREQEEKVWRQEEKIREQEEKIREQE 598
Query: 138 EEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEP 197
E+I ++E + + QE K E E E E + + E E E+ ++E
Sbjct: 599 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 658
Query: 198 RLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKR 257
+ + +++++ QE + ++K EQE K +E + + ++ + +++++E++
Sbjct: 659 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
Query: 258 SLAA 261
L A
Sbjct: 719 HLEA 722
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 77.4 bits (189), Expect = 2e-14
Identities = 90/343 (26%), Positives = 141/343 (41%), Gaps = 54/343 (15%)
Query: 29 ISMEKVK---VKRYVSGKRPDYAPMESSD--EEDEEFQFIKKAKEQEAEPEEQEEDSSSD 83
I ME+ K + R +S R + +E +E E + K+ +E+E E E + E +
Sbjct: 267 IEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERE 326
Query: 84 PRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWR-------------MERE 130
R + R E ER + + + D + E D R RE
Sbjct: 327 REREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSRE 386
Query: 131 DSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYE---- 186
S + E E + E ER R R+R +ER+ E E E + + E + E YE
Sbjct: 387 KSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKL 446
Query: 187 --EYTDSEDEMEPRLKPVFIR--KKDRVTVQEREAEALKQKELEQEAKRMAEERRKYT-- 240
+ + E + RLK IR KK R +E E E +++E+ +EAKR+ E Y
Sbjct: 447 ERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDD 506
Query: 241 ---------------LKIVEEET----------KKELEENKRSLAALDALNTDDENDEEE 275
L+ E+E K+ELEE ++ L A + D E E
Sbjct: 507 RDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRME 566
Query: 276 YEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAE 318
EA + R+ +IK++ E E E+++ + E+ EEE E
Sbjct: 567 QEAERRRQ-PQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPE 608
Score = 76.6 bits (187), Expect = 4e-14
Identities = 95/398 (23%), Positives = 158/398 (39%), Gaps = 88/398 (22%)
Query: 26 KGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEF----QFIKKA-----KEQEAEPEEQ 76
K ++ K K K RP+ + + DEE Q IK A +E +E
Sbjct: 166 KAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAP 225
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVE--------------- 121
++S S PR ++ + + ED+ R I P + E + +E
Sbjct: 226 SQESDSHPRKKKKEKK--EDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISK 283
Query: 122 -GDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESE 180
D + E+ ++E+E + E+ R R R+R +ER+ E E E E E +E E
Sbjct: 284 FRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERE-REREREREKEKERE 342
Query: 181 SESEYEEYTD---------------------SEDEMEPRLKPVFIRKKDRVTVQEREAEA 219
E E + D S D + R + R+K R +ERE E
Sbjct: 343 RERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS---REKSRDRERERERER 399
Query: 220 LKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAW 279
+++E E+E +R E R E E ++E E++K+ + +E+E +A+
Sbjct: 400 ERERERERERERERERER-------EREREREREKDKKR-----------DREEDEEDAY 441
Query: 280 KVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQ 339
+ R+L+R R++E + EI + E E+ AE + K K +FL+
Sbjct: 442 ERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLE 501
Query: 340 KY--------YHRGAFF----------MDEDEEVYKRD 359
Y Y+RG+ M+ DE KR+
Sbjct: 502 DYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKRE 539
Score = 49.7 bits (117), Expect = 5e-06
Identities = 59/229 (25%), Positives = 109/229 (47%), Gaps = 21/229 (9%)
Query: 54 DEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVV 113
+ E E + ++ K+++ + EE EED+ +L R +ERL ++ +I E +
Sbjct: 414 EREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERL-KNWEIRERKKT 472
Query: 114 GESDSEVEGDAWRMEREDSSEEEE-----EEIDDEEIERR--RGMMRQRAQERKNEEMEV 166
E + E E + R RE + E + E+ DD+ + + RG Q+ + +EME
Sbjct: 473 REYEKEAEREEER-RREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEA 531
Query: 167 MEVEDEGRSGEESESESEY---EEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQK 223
E D R EE E + E + D + E++ R++ R++ QE E+E
Sbjct: 532 DE-RDRKREKEELEEIRQRLLAEGHPDPDAELQ-RMEQEAERRRQPQIKQEPESEE---- 585
Query: 224 ELEQEAKRMAEERRKYTLKIVEE-ETKKELEENKRSLAALDALNTDDEN 271
E+E K+ EE+R+ ++ EE E K L+ R +++ ++++ N
Sbjct: 586 --EEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGN 632
Score = 49.7 bits (117), Expect = 5e-06
Identities = 51/190 (26%), Positives = 81/190 (42%), Gaps = 18/190 (9%)
Query: 23 RNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSS 82
R E E + E+ K++R + K Y + E E + + KE E E E + E +
Sbjct: 433 REEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKE 492
Query: 83 DPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEI-- 140
RL+ +D ++ +R + + + + E+E D +RE +EE EEI
Sbjct: 493 AKRLKEFLEDYDDDRDDP-KYYRGSALQKRLRDREKEMEADERDRKRE---KEELEEIRQ 548
Query: 141 ---------DDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDS 191
D E++R +R Q + +E E E E+E + EE E EE
Sbjct: 549 RLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEE---E 605
Query: 192 EDEMEPRLKP 201
E E +P LKP
Sbjct: 606 EPEQKPCLKP 615
Score = 47.8 bits (112), Expect = 2e-05
Identities = 53/231 (22%), Positives = 97/231 (41%), Gaps = 28/231 (12%)
Query: 100 RLARHRKIVEPEVVGESDSEVEG--DAWRMEREDSS--------EEEEEEIDDEEIERRR 149
RL +I E +++ + D++ + D W+ +++ S+ ++EE DEE +RR
Sbjct: 145 RLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRD 204
Query: 150 GMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDR 209
M++ + E + + + + E +E + P + I K+D
Sbjct: 205 QMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKED- 263
Query: 210 VTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDD 269
+ E E K+ + +E + + + K+ EE+ KKE E + +
Sbjct: 264 --INAIEMEEDKRDLISREISKFRDTHK----KLEEEKGKKEKERQE----------IEK 307
Query: 270 ENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELR 320
E E E E + RE + +R+RE EKEK E ER R + R + R
Sbjct: 308 ERRERERERERERERREREREREREREREKEK-ERERERERDRDRDRTKER 357
Score = 29.3 bits (64), Expect = 7.4
Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 3/52 (5%)
Query: 43 KRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRIS 94
++P S+EE+EE Q + +E+ EP E+EE+ P L+ IS
Sbjct: 573 RQPQIKQEPESEEEEEEKQ---EKEEKREEPMEEEEEPEQKPCLKPTLRPIS 621
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 74.7 bits (182), Expect = 2e-13
Identities = 72/305 (23%), Positives = 150/305 (49%), Gaps = 27/305 (8%)
Query: 24 NEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDS-SS 82
N++ E M + + K ++ ++ ++E++ ++ +K EQE + EQE+
Sbjct: 292 NQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQ 351
Query: 83 DPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDD 142
+ ++R + +I E E+ + KI E + E E E + WR E + +EE+ +
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQD---EKIQEQEEEMWRQEEKIREQEEKRQ--- 405
Query: 143 EEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPV 202
E++ R+ MR++ ++ + +E E+ E++ R EE + E E+ + E++M+
Sbjct: 406 EKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQE-EKLREVEEKMQ------ 458
Query: 203 FIRKKDRVTVQEREAEALKQKELEQEAKRMAEER-RKYTLKIVEEETKKELEENKRSLAA 261
+++++ QE + + ++K EQE K +E+ K KI E+E K +E K
Sbjct: 459 --EEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEK----- 511
Query: 262 LDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRA 321
+ +E +E+ E + +E K R++E R ++EK + + +R EER +L
Sbjct: 512 ---MWEQEEKMQEQEEKMQRQEEK--MREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQ 566
Query: 322 NGKVI 326
+++
Sbjct: 567 KAELL 571
Score = 65.1 bits (157), Expect = 1e-10
Identities = 76/348 (21%), Positives = 155/348 (44%), Gaps = 68/348 (19%)
Query: 24 NEKGEISMEKVKVKR-------YVSGKRPDYAPMESSDEEDEEFQ---FIKK-AKEQEA- 71
NEK ++V +K+ + KRP+ + +E + D + +I+K KE++A
Sbjct: 143 NEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAP 202
Query: 72 ----------EPEEQEEDSSSDPRLRRLQNRISE------DVEERLARHRKI-------V 108
+ E +E+++ +LR +++ SE D++ +L R + + V
Sbjct: 203 SLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQV 262
Query: 109 EPEVVGESDSEV---------EGDAWRM---EREDSSEEEEEEIDDEEIERRRGMMRQRA 156
E + +G+ V E + W + ++E+ +EE+I ++E + ++ R
Sbjct: 263 EADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIRE 322
Query: 157 QERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQERE 216
QE K E E E + E+ + EE ++E + R+++++ Q+ +
Sbjct: 323 QEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEK 382
Query: 217 AEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEY 276
+ +++ QE K +E ++ +E+ +E +E R E+E
Sbjct: 383 IQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIR---------------EQEE 427
Query: 277 EAW----KVRELKRIKRDRED--REALEKEKAEIERMRNLTEEERRAE 318
E W K+REL+ + +D+E+ RE EK + E E+M+ E+ +R E
Sbjct: 428 EMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQE 475
Score = 50.4 bits (119), Expect = 3e-06
Identities = 52/243 (21%), Positives = 103/243 (42%), Gaps = 49/243 (20%)
Query: 23 RNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEED--- 79
+ EK EK++ + ++ + + +++ ++ KK +EQ+ + EQEE+
Sbjct: 372 QEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWR 431
Query: 80 ------------SSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRM 127
+ +LR ++ ++ E+ E+ + KI E E E E WR
Sbjct: 432 QEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQE---EKIQEQEEKTWRQ 488
Query: 128 ER-------------------------EDSSEEEEEEIDDEEIERRRGMMRQRAQERKNE 162
E+ E+ +E+EE++ +E + R +R QE K +
Sbjct: 489 EKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQ 548
Query: 163 EMEVMEVEDEGRSGE-ESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALK 221
E EV E E R G+ ++E +S + P L P+ +V ++ +EA++L+
Sbjct: 549 EQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPIL-----QVELKSQEAQSLQ 603
Query: 222 QKE 224
Q++
Sbjct: 604 QQQ 606
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 74.7 bits (182), Expect = 2e-13
Identities = 72/305 (23%), Positives = 150/305 (49%), Gaps = 27/305 (8%)
Query: 24 NEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDS-SS 82
N++ E M + + K ++ ++ ++E++ ++ +K EQE + EQE+
Sbjct: 292 NQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQ 351
Query: 83 DPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDD 142
+ ++R + +I E E+ + KI E + E E E + WR E + +EE+ +
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQD---EKIQEQEEEMWRQEEKIREQEEKRQ--- 405
Query: 143 EEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPV 202
E++ R+ MR++ ++ + +E E+ E++ R EE + E E+ + E++M+
Sbjct: 406 EKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQE-EKLREVEEKMQ------ 458
Query: 203 FIRKKDRVTVQEREAEALKQKELEQEAKRMAEER-RKYTLKIVEEETKKELEENKRSLAA 261
+++++ QE + + ++K EQE K +E+ K KI E+E K +E K
Sbjct: 459 --EEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEK----- 511
Query: 262 LDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRA 321
+ +E +E+ E + +E K R++E R ++EK + + +R EER +L
Sbjct: 512 ---MWEQEEKMQEQEEKMQRQEEK--MREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQ 566
Query: 322 NGKVI 326
+++
Sbjct: 567 KAELL 571
Score = 65.1 bits (157), Expect = 1e-10
Identities = 76/348 (21%), Positives = 155/348 (44%), Gaps = 68/348 (19%)
Query: 24 NEKGEISMEKVKVKR-------YVSGKRPDYAPMESSDEEDEEFQ---FIKK-AKEQEA- 71
NEK ++V +K+ + KRP+ + +E + D + +I+K KE++A
Sbjct: 143 NEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAL 202
Query: 72 ----------EPEEQEEDSSSDPRLRRLQNRISE------DVEERLARHRKI-------V 108
+ E +E+++ +LR +++ SE D++ +L R + + V
Sbjct: 203 SLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQV 262
Query: 109 EPEVVGESDSEV---------EGDAWRM---EREDSSEEEEEEIDDEEIERRRGMMRQRA 156
E + +G+ V E + W + ++E+ +EE+I ++E + ++ R
Sbjct: 263 EADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIRE 322
Query: 157 QERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQERE 216
QE K E E E + E+ + EE ++E + R+++++ Q+ +
Sbjct: 323 QEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEK 382
Query: 217 AEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEY 276
+ +++ QE K +E ++ +E+ +E +E R E+E
Sbjct: 383 IQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIR---------------EQEE 427
Query: 277 EAW----KVRELKRIKRDRED--REALEKEKAEIERMRNLTEEERRAE 318
E W K+REL+ + +D+E+ RE EK + E E+M+ E+ +R E
Sbjct: 428 EMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQE 475
Score = 50.4 bits (119), Expect = 3e-06
Identities = 52/243 (21%), Positives = 103/243 (42%), Gaps = 49/243 (20%)
Query: 23 RNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEED--- 79
+ EK EK++ + ++ + + +++ ++ KK +EQ+ + EQEE+
Sbjct: 372 QEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWR 431
Query: 80 ------------SSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRM 127
+ +LR ++ ++ E+ E+ + KI E E E E WR
Sbjct: 432 QEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQE---EKIQEQEEKTWRQ 488
Query: 128 ER-------------------------EDSSEEEEEEIDDEEIERRRGMMRQRAQERKNE 162
E+ E+ +E+EE++ +E + R +R QE K +
Sbjct: 489 EKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQ 548
Query: 163 EMEVMEVEDEGRSGE-ESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALK 221
E EV E E R G+ ++E +S + P L P+ +V ++ +EA++L+
Sbjct: 549 EQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPIL-----QVELKSQEAQSLQ 603
Query: 222 QKE 224
Q++
Sbjct: 604 QQQ 606
>gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
Length = 675
Score = 74.3 bits (181), Expect = 2e-13
Identities = 102/445 (22%), Positives = 188/445 (42%), Gaps = 89/445 (20%)
Query: 35 KVKRYVSGKRP---DYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQ- 90
K + +S +P Y P + ++F+ +++A+E+ + ++E + R +
Sbjct: 7 KAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIRERE 66
Query: 91 -NRISEDVEERLARHRKI-----VEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEE 144
NR ++++E LA + VE V + V+G ME++ +EE+ + +EE
Sbjct: 67 WNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQ--RQEEQRKRTEEE 124
Query: 145 IERR--RGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEE--------------- 187
+RR + M+ +R +R+ + ++ED +G ES SE +
Sbjct: 125 RKRRIEQDMLEKRKIQRELAK-RAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSG 183
Query: 188 -----YTDSEDEMEPRLKPVFIRKKDRVTVQE-----REAEALK---QKELEQEAKR--- 231
+ D E E E + + + K R+ +E +EA+ L E+E EAK+
Sbjct: 184 KMKKNFEDLEKEREEKERIKYEEDK-RIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESL 242
Query: 232 -----------MAEERRKYTLKIVEEETKKELEENKRSL--AALDALNTDDENDE--EEY 276
+ +R++ K EEE +K LEE KR+ A +N D+EN + + +
Sbjct: 243 SPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIF 302
Query: 277 EAWKVRELKRIKRDRE-DREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKY 335
+ ++ +LK + E R EK KAE E R + EEE++A A ++ +
Sbjct: 303 KGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRI-EEEKKAFAEARRNMVVD------- 354
Query: 336 KFLQKYYHRGAFFMDEDEEVYK---RDFSAP-TLEDHFNKTILPKVMQVKNFGRSGRTKY 391
D+ E+YK ++F P LE +F + + K+ + K R
Sbjct: 355 --------------DDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHK 400
Query: 392 THLVDQDTTSFDSAWGQESAQNTKF 416
+ Q+ G+E +N F
Sbjct: 401 LEMEKQEFEQLRQEMGEEEEENETF 425
Score = 50.8 bits (120), Expect = 2e-06
Identities = 77/346 (22%), Positives = 150/346 (43%), Gaps = 31/346 (8%)
Query: 6 ALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKK 65
+L+ I+S A + K +++ E+++ +R + K+ A E+ +EE + ++
Sbjct: 226 SLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQ--AEEEARKRLEEEKRAFEE 283
Query: 66 AKEQEAEPEEQEEDSS-------------SDPRLRRLQNRISEDVEERLARHRKIVEPEV 112
A+ Q +E+ +D++ S + R + + E AR R E +
Sbjct: 284 ARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKA 343
Query: 113 VGES--DSEVEGDAWRMEREDSSE---EEEEEIDDEEI--ERRRGMMRQRAQERKNE-EM 164
E+ + V+ D+ M + S E + EI+ EE+ ++ R+ +ERK++ EM
Sbjct: 344 FAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEM 403
Query: 165 EVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKE 224
E E E + E E E+E + +E+ + I+ K+ + E+ + L +KE
Sbjct: 404 EKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQ-LSEKE 462
Query: 225 LEQEAKRMAEERRKYTLKIVEEETKKELEENK---RSLAALDALNTDDENDEEEYE---- 277
++++ + RR L+I E E + EE+ R +A T N + +E
Sbjct: 463 IQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAK 522
Query: 278 AWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANG 323
A + E +RI+ + R E+ + + + EEE NG
Sbjct: 523 AREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNG 568
Score = 31.6 bits (70), Expect = 1.5
Identities = 42/194 (21%), Positives = 73/194 (37%), Gaps = 16/194 (8%)
Query: 7 LMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKA 66
L+KQ + R K E+ ++ + R G+ + E EE +K++
Sbjct: 381 LLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRS 440
Query: 67 KEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVG---ESDSEVE-- 121
+A+ + + + + +Q +I E+ R A +I E E E D +V
Sbjct: 441 GSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPA 500
Query: 122 -----------GDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVE 170
R E+ + EEEE+ EE + R QR + ++ E E
Sbjct: 501 RKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEE 560
Query: 171 DEGRSGEESESESE 184
+EG S +E E
Sbjct: 561 EEGSIMNGSTAEDE 574
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 73.2 bits (178), Expect = 4e-13
Identities = 74/291 (25%), Positives = 130/291 (44%), Gaps = 36/291 (12%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERL-----ARHRKIVEPEVVGESDS 118
++ +Q+AE E E++ + L R Q + +E + RL A+ + + + E + +
Sbjct: 1611 ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE- 1667
Query: 119 EVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEE 178
E E +A R + + + E+ ++E+E++R + AQ+R E E++ + E GE+
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 179 SES---------ESEYEEYTDSEDEMEPRL------KPVFIRKKDRVTVQEREAEALKQK 223
+ E T E+E L V + K R + R ++
Sbjct: 1728 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1787
Query: 224 ELEQEAKR---MAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAW- 279
LE EA R +AEE + L+ + EE K++ R LA DA E + E
Sbjct: 1788 RLEAEAGRFRELAEEAAR--LRALAEEAKRQ-----RQLAEEDAARQRAEAERVLAEKLA 1840
Query: 280 KVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKA 330
+ E R+K + E AL++++AE ER+R L E+E R + +KA
Sbjct: 1841 AIGEATRLKTEAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889
Score = 66.2 bits (160), Expect = 5e-11
Identities = 68/330 (20%), Positives = 138/330 (41%), Gaps = 22/330 (6%)
Query: 3 VPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQF 62
V +AL KQ + + E+ +++ + V + + EE Q
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424
Query: 63 IKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG 122
++++ E E + + ++ +++ RLR +EE + R +E +E E
Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLR---------IEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 123 DAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVME-VEDEGRSGEESES 181
A R E++ ++ + EE ER R ++ +Q ++ E+E+ V+ E + E +
Sbjct: 1476 QALRARAEEAEAQKRQA--QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533
Query: 182 ESE-YEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYT 240
+ EE +E E RL+ + + +V V A+ + EL+ + AE+ +
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593
Query: 241 LKIVEE-----ETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIK-RDREDR 294
+ EE + ++E E + A + E E E E W+++ + ++ R + +
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAR---EEAERELERWQLKANEALRLRLQAEE 1650
Query: 295 EALEKEKAEIERMRNLTEEERRAELRANGK 324
A +K A+ E + E ER A R +
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680
Score = 57.4 bits (137), Expect = 3e-08
Identities = 79/335 (23%), Positives = 137/335 (40%), Gaps = 53/335 (15%)
Query: 13 IQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAE 72
+Q A A + ++ E + KV+ + V ++ EE+ K + EAE
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 73 PEEQEEDSSSDPRLRRLQNRISED---VEERLARHRKIVEPEVVGESDSEVEGDAWRMER 129
E + RLR L EE AR R E V+ E + + G+A R++
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLAEKLAAI-GEATRLKT 1850
Query: 130 EDSSEEEEEEIDDEEIER--------RRGMMRQRAQERKNEEMEVME------------- 168
E +E+E ++E + R RR + Q AQ + + E + +
Sbjct: 1851 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910
Query: 169 --VEDEGRSGEESESE-----SEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER-EAEAL 220
VED R + E E + +E+ + E+E L + +D + +E+ E EA
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970
Query: 221 KQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWK 280
+Q++L E +R RR+ + V++ E E ++ AAL +E E K
Sbjct: 1971 RQRQLAAEEER----RRREAEERVQKSLAAEEEAARQRKAAL---------EEVERLKAK 2017
Query: 281 VRELKRIKRDREDREALEKEKAEIERMRNLTEEER 315
V E +R++ E A + + A+ + L EE+
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2052
Score = 55.1 bits (131), Expect = 1e-07
Identities = 74/348 (21%), Positives = 148/348 (42%), Gaps = 55/348 (15%)
Query: 8 MKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPM-ESSDEEDEEFQFIKKA 66
M + +Q+ A ++ E + +K + + D M + EE + FQ
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ----- 2365
Query: 67 KEQEAEPEEQEEDSSSDPRLR-------RLQNRISEDVE----------ERLARHRKIVE 109
+ EAE + Q E S+ RL+ R Q R ED + E+L R +
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425
Query: 110 PEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV 169
+V E++ R + + +E E I + E E+ + + + K+EEM+ ++
Sbjct: 2426 EKVTLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2481
Query: 170 EDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER--EAEALKQKELEQ 227
E + +E+++ L+ F+ +KD + +ER E E K ++L Q
Sbjct: 2482 E---QLLQETQA-----------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2521
Query: 228 EAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRI 287
+ A++ R+ ++ ++++E+ ++ L A +++ EE K EL+++
Sbjct: 2522 DEVAKAQQLRE-----EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2576
Query: 288 KRD-REDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGK 334
++ R+ E L +E + L EE+ RA L + +V ++ K
Sbjct: 2577 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2624
Score = 52.8 bits (125), Expect = 6e-07
Identities = 76/355 (21%), Positives = 152/355 (42%), Gaps = 63/355 (17%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEF--QFIKKAKEQEAEPEEQ 76
A P + K + E V ++ YV R Y+ + + + +F + +++ +E+E E+Q
Sbjct: 1297 ASPAKKPKVQSGSESV-IQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG-DAWRMEREDSSEE 135
+ + R++E VE L + R++ E ++ +E E + + +E+
Sbjct: 1355 RAEE---------RERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 136 EEEEIDDEEIER---------------------RRGMMRQRAQERKNEEMEVMEVEDEGR 174
EE +D ++ +R R+ +R++ R EE+ V+ ++ E
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 175 SGEESESESEYEEYTDSEDEMEPRLKPV------FIRKKDRVTVQEREAEALKQKELEQE 228
+ +E E + +E E + + R+ + ++R+AE ++ E
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524
Query: 229 AKRMAEERRKY----TLKIVEEETKKELE--ENKRSLAALDALNTDDENDEEEYE----- 277
A+ E++R L++ EE ++ L E +R+ AL T + E E +
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1584
Query: 278 -AWKVRELKR--------IKRDREDREALEKEKAEIERMRNLTEEE-RRAELRAN 322
A K +L+R + + RE+ E +++AE ER R E E R +L+AN
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1639
Score = 50.1 bits (118), Expect = 4e-06
Identities = 61/311 (19%), Positives = 144/311 (46%), Gaps = 36/311 (11%)
Query: 58 EEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQ-------NRISEDVEERLARHRKIVEP 110
EE + +++ EQE+ + Q ++ RL+ + + +++++ L + + +++
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD- 2077
Query: 111 EVVGESD----SEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKN----- 161
++ GE++ + E + R++ E + + ++ EE ER + ++AQ R
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAA 2135
Query: 162 EEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRV-----TVQERE 216
E++ ++ R + ++ ++ D+E E + +R+K +V T++ +
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 217 AEALKQKE-LEQEAKRM---AEERRKYTLKIVEE--ETKKELEENKRSLAALDALNTD-D 269
E QK L++E +R+ A E + ++ EE + ++EE + A ++A N
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255
Query: 270 ENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNK 329
D++ + + E +++K+ E+ L E R+R L EE+ A + + K
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEK 2310
Query: 330 AVKGKYKFLQK 340
+K K + +Q+
Sbjct: 2311 MLKEKMQAVQE 2321
Score = 48.1 bits (113), Expect = 2e-05
Identities = 75/349 (21%), Positives = 135/349 (38%), Gaps = 65/349 (18%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEP--EEQ 76
A R E +V+ +R + R E + EE + + AE +E
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEE 136
E++++ + + R + + + +H+K E + ++ E E R++ E++ +
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET--DH 2200
Query: 137 EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV--------------EDEGRS------- 175
++ + DEE++R + + A++R E E+ V E E R+
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2260
Query: 176 ------GEESESESEYEEYTD----------------SEDEMEPRLKPVFIRKKDRVTVQ 213
EE+E + E ED + R + K+ VQ
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320
Query: 214 ER-----EAEALKQ-KELEQEAKRMAEERRKYTLKIVEEET---KKELEENKRSLAALDA 264
E EAE L+Q KEL QE R +E ++ + + EET ++ LE ++ + A
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 265 LNTDDENDEEEYEAWKVRELKRIK-RDREDREALEKEKAEIERMRNLTE 312
E E +V E+ R + R ED + K+ EI + TE
Sbjct: 2381 --------EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2421
Score = 42.0 bits (97), Expect = 0.001
Identities = 53/260 (20%), Positives = 115/260 (44%), Gaps = 24/260 (9%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVE-ERLARHRKIVEPEVVGESDSEVEG 122
++ +E AE E ++E + +L +L++ + V+ E+L + + ++ + E DS ++
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 123 DAWRMEREDSSEEE--EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESE 180
+ + +E+E + E+ ++E+ + + R RQ+ Q + + V +E+ R E+E
Sbjct: 2506 ERF-IEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563
Query: 181 SESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELE--QEAKRMAEERRK 238
E ++E++ ++ Q R+ E L +E + +E ++ EE+ +
Sbjct: 2564 -----EGVRRKQEELQ------------QLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606
Query: 239 YTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALE 298
L EE T ++ K DAL+ E E+ +R +R +E
Sbjct: 2607 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2666
Query: 299 KEKAEIERMRNLTEEERRAE 318
+E + + +E R E
Sbjct: 2667 EELQRLAQGHTTVDELARRE 2686
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 73.2 bits (178), Expect = 4e-13
Identities = 74/291 (25%), Positives = 130/291 (44%), Gaps = 36/291 (12%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERL-----ARHRKIVEPEVVGESDS 118
++ +Q+AE E E++ + L R Q + +E + RL A+ + + + E + +
Sbjct: 1615 ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE- 1671
Query: 119 EVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEE 178
E E +A R + + + E+ ++E+E++R + AQ+R E E++ + E GE+
Sbjct: 1672 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1731
Query: 179 SES---------ESEYEEYTDSEDEMEPRL------KPVFIRKKDRVTVQEREAEALKQK 223
+ E T E+E L V + K R + R ++
Sbjct: 1732 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1791
Query: 224 ELEQEAKR---MAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAW- 279
LE EA R +AEE + L+ + EE K++ R LA DA E + E
Sbjct: 1792 RLEAEAGRFRELAEEAAR--LRALAEEAKRQ-----RQLAEEDAARQRAEAERVLAEKLA 1844
Query: 280 KVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKA 330
+ E R+K + E AL++++AE ER+R L E+E R + +KA
Sbjct: 1845 AIGEATRLKTEAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1893
Score = 66.2 bits (160), Expect = 5e-11
Identities = 68/330 (20%), Positives = 138/330 (41%), Gaps = 22/330 (6%)
Query: 3 VPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQF 62
V +AL KQ + + E+ +++ + V + + EE Q
Sbjct: 1369 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1428
Query: 63 IKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG 122
++++ E E + + ++ +++ RLR +EE + R +E +E E
Sbjct: 1429 LRQSSEAEIQAKARQAEAAERSRLR---------IEEEIRVVRLQLEATERQRGGAEGEL 1479
Query: 123 DAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVME-VEDEGRSGEESES 181
A R E++ ++ + EE ER R ++ +Q ++ E+E+ V+ E + E +
Sbjct: 1480 QALRARAEEAEAQKRQA--QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1537
Query: 182 ESE-YEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYT 240
+ EE +E E RL+ + + +V V A+ + EL+ + AE+ +
Sbjct: 1538 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1597
Query: 241 LKIVEE-----ETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIK-RDREDR 294
+ EE + ++E E + A + E E E E W+++ + ++ R + +
Sbjct: 1598 RSLQEEHVAVAQLREEAERRAQQQAEAERAR---EEAERELERWQLKANEALRLRLQAEE 1654
Query: 295 EALEKEKAEIERMRNLTEEERRAELRANGK 324
A +K A+ E + E ER A R +
Sbjct: 1655 VAQQKSLAQAEAEKQKEEAEREARRRGKAE 1684
Score = 57.4 bits (137), Expect = 3e-08
Identities = 79/335 (23%), Positives = 137/335 (40%), Gaps = 53/335 (15%)
Query: 13 IQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAE 72
+Q A A + ++ E + KV+ + V ++ EE+ K + EAE
Sbjct: 1743 LQREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAE 1796
Query: 73 PEEQEEDSSSDPRLRRLQNRISED---VEERLARHRKIVEPEVVGESDSEVEGDAWRMER 129
E + RLR L EE AR R E V+ E + + G+A R++
Sbjct: 1797 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLAEKLAAI-GEATRLKT 1854
Query: 130 EDSSEEEEEEIDDEEIER--------RRGMMRQRAQERKNEEMEVME------------- 168
E +E+E ++E + R RR + Q AQ + + E + +
Sbjct: 1855 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1914
Query: 169 --VEDEGRSGEESESE-----SEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER-EAEAL 220
VED R + E E + +E+ + E+E L + +D + +E+ E EA
Sbjct: 1915 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1974
Query: 221 KQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWK 280
+Q++L E +R RR+ + V++ E E ++ AAL +E E K
Sbjct: 1975 RQRQLAAEEER----RRREAEERVQKSLAAEEEAARQRKAAL---------EEVERLKAK 2021
Query: 281 VRELKRIKRDREDREALEKEKAEIERMRNLTEEER 315
V E +R++ E A + + A+ + L EE+
Sbjct: 2022 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2056
Score = 55.1 bits (131), Expect = 1e-07
Identities = 74/348 (21%), Positives = 148/348 (42%), Gaps = 55/348 (15%)
Query: 8 MKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPM-ESSDEEDEEFQFIKKA 66
M + +Q+ A ++ E + +K + + D M + EE + FQ
Sbjct: 2315 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ----- 2369
Query: 67 KEQEAEPEEQEEDSSSDPRLR-------RLQNRISEDVE----------ERLARHRKIVE 109
+ EAE + Q E S+ RL+ R Q R ED + E+L R +
Sbjct: 2370 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2429
Query: 110 PEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV 169
+V E++ R + + +E E I + E E+ + + + K+EEM+ ++
Sbjct: 2430 EKVTLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2485
Query: 170 EDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER--EAEALKQKELEQ 227
E + +E+++ L+ F+ +KD + +ER E E K ++L Q
Sbjct: 2486 E---QLLQETQA-----------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2525
Query: 228 EAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRI 287
+ A++ R+ ++ ++++E+ ++ L A +++ EE K EL+++
Sbjct: 2526 DEVAKAQQLRE-----EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2580
Query: 288 KRD-REDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGK 334
++ R+ E L +E + L EE+ RA L + +V ++ K
Sbjct: 2581 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2628
Score = 52.8 bits (125), Expect = 6e-07
Identities = 76/355 (21%), Positives = 152/355 (42%), Gaps = 63/355 (17%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEF--QFIKKAKEQEAEPEEQ 76
A P + K + E V ++ YV R Y+ + + + +F + +++ +E+E E+Q
Sbjct: 1301 ASPAKKPKVQSGSESV-IQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1358
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG-DAWRMEREDSSEE 135
+ + R++E VE L + R++ E ++ +E E + + +E+
Sbjct: 1359 RAEE---------RERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1408
Query: 136 EEEEIDDEEIER---------------------RRGMMRQRAQERKNEEMEVMEVEDEGR 174
EE +D ++ +R R+ +R++ R EE+ V+ ++ E
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1468
Query: 175 SGEESESESEYEEYTDSEDEMEPRLKPV------FIRKKDRVTVQEREAEALKQKELEQE 228
+ +E E + +E E + + R+ + ++R+AE ++ E
Sbjct: 1469 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1528
Query: 229 AKRMAEERRKY----TLKIVEEETKKELE--ENKRSLAALDALNTDDENDEEEYE----- 277
A+ E++R L++ EE ++ L E +R+ AL T + E E +
Sbjct: 1529 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1588
Query: 278 -AWKVRELKR--------IKRDREDREALEKEKAEIERMRNLTEEE-RRAELRAN 322
A K +L+R + + RE+ E +++AE ER R E E R +L+AN
Sbjct: 1589 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1643
Score = 50.1 bits (118), Expect = 4e-06
Identities = 61/311 (19%), Positives = 144/311 (46%), Gaps = 36/311 (11%)
Query: 58 EEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQ-------NRISEDVEERLARHRKIVEP 110
EE + +++ EQE+ + Q ++ RL+ + + +++++ L + + +++
Sbjct: 2023 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD- 2081
Query: 111 EVVGESD----SEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKN----- 161
++ GE++ + E + R++ E + + ++ EE ER + ++AQ R
Sbjct: 2082 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAA 2139
Query: 162 EEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRV-----TVQERE 216
E++ ++ R + ++ ++ D+E E + +R+K +V T++ +
Sbjct: 2140 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2199
Query: 217 AEALKQKE-LEQEAKRM---AEERRKYTLKIVEE--ETKKELEENKRSLAALDALNTD-D 269
E QK L++E +R+ A E + ++ EE + ++EE + A ++A N
Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2259
Query: 270 ENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNK 329
D++ + + E +++K+ E+ L E R+R L EE+ A + + K
Sbjct: 2260 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEK 2314
Query: 330 AVKGKYKFLQK 340
+K K + +Q+
Sbjct: 2315 MLKEKMQAVQE 2325
Score = 48.1 bits (113), Expect = 2e-05
Identities = 75/349 (21%), Positives = 135/349 (38%), Gaps = 65/349 (18%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEP--EEQ 76
A R E +V+ +R + R E + EE + + AE +E
Sbjct: 2087 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2146
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEE 136
E++++ + + R + + + +H+K E + ++ E E R++ E++ +
Sbjct: 2147 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET--DH 2204
Query: 137 EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV--------------EDEGRS------- 175
++ + DEE++R + + A++R E E+ V E E R+
Sbjct: 2205 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2264
Query: 176 ------GEESESESEYEEYTD----------------SEDEMEPRLKPVFIRKKDRVTVQ 213
EE+E + E ED + R + K+ VQ
Sbjct: 2265 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2324
Query: 214 ER-----EAEALKQ-KELEQEAKRMAEERRKYTLKIVEEET---KKELEENKRSLAALDA 264
E EAE L+Q KEL QE R +E ++ + + EET ++ LE ++ + A
Sbjct: 2325 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2384
Query: 265 LNTDDENDEEEYEAWKVRELKRIK-RDREDREALEKEKAEIERMRNLTE 312
E E +V E+ R + R ED + K+ EI + TE
Sbjct: 2385 --------EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2425
Score = 42.0 bits (97), Expect = 0.001
Identities = 53/260 (20%), Positives = 115/260 (44%), Gaps = 24/260 (9%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVE-ERLARHRKIVEPEVVGESDSEVEG 122
++ +E AE E ++E + +L +L++ + V+ E+L + + ++ + E DS ++
Sbjct: 2450 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2509
Query: 123 DAWRMEREDSSEEE--EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESE 180
+ + +E+E + E+ ++E+ + + R RQ+ Q + + V +E+ R E+E
Sbjct: 2510 ERF-IEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2567
Query: 181 SESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELE--QEAKRMAEERRK 238
E ++E++ ++ Q R+ E L +E + +E ++ EE+ +
Sbjct: 2568 -----EGVRRKQEELQ------------QLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2610
Query: 239 YTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALE 298
L EE T ++ K DAL+ E E+ +R +R +E
Sbjct: 2611 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2670
Query: 299 KEKAEIERMRNLTEEERRAE 318
+E + + +E R E
Sbjct: 2671 EELQRLAQGHTTVDELARRE 2690
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 73.2 bits (178), Expect = 4e-13
Identities = 74/291 (25%), Positives = 130/291 (44%), Gaps = 36/291 (12%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERL-----ARHRKIVEPEVVGESDS 118
++ +Q+AE E E++ + L R Q + +E + RL A+ + + + E + +
Sbjct: 1611 ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE- 1667
Query: 119 EVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEE 178
E E +A R + + + E+ ++E+E++R + AQ+R E E++ + E GE+
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 179 SES---------ESEYEEYTDSEDEMEPRL------KPVFIRKKDRVTVQEREAEALKQK 223
+ E T E+E L V + K R + R ++
Sbjct: 1728 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1787
Query: 224 ELEQEAKR---MAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAW- 279
LE EA R +AEE + L+ + EE K++ R LA DA E + E
Sbjct: 1788 RLEAEAGRFRELAEEAAR--LRALAEEAKRQ-----RQLAEEDAARQRAEAERVLAEKLA 1840
Query: 280 KVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKA 330
+ E R+K + E AL++++AE ER+R L E+E R + +KA
Sbjct: 1841 AIGEATRLKTEAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889
Score = 66.2 bits (160), Expect = 5e-11
Identities = 68/330 (20%), Positives = 138/330 (41%), Gaps = 22/330 (6%)
Query: 3 VPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQF 62
V +AL KQ + + E+ +++ + V + + EE Q
Sbjct: 1365 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424
Query: 63 IKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG 122
++++ E E + + ++ +++ RLR +EE + R +E +E E
Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLR---------IEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 123 DAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVME-VEDEGRSGEESES 181
A R E++ ++ + EE ER R ++ +Q ++ E+E+ V+ E + E +
Sbjct: 1476 QALRARAEEAEAQKRQA--QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533
Query: 182 ESE-YEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYT 240
+ EE +E E RL+ + + +V V A+ + EL+ + AE+ +
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593
Query: 241 LKIVEE-----ETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIK-RDREDR 294
+ EE + ++E E + A + E E E E W+++ + ++ R + +
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAR---EEAERELERWQLKANEALRLRLQAEE 1650
Query: 295 EALEKEKAEIERMRNLTEEERRAELRANGK 324
A +K A+ E + E ER A R +
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680
Score = 57.4 bits (137), Expect = 3e-08
Identities = 79/335 (23%), Positives = 137/335 (40%), Gaps = 53/335 (15%)
Query: 13 IQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAE 72
+Q A A + ++ E + KV+ + V ++ EE+ K + EAE
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 73 PEEQEEDSSSDPRLRRLQNRISED---VEERLARHRKIVEPEVVGESDSEVEGDAWRMER 129
E + RLR L EE AR R E V+ E + + G+A R++
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLAEKLAAI-GEATRLKT 1850
Query: 130 EDSSEEEEEEIDDEEIER--------RRGMMRQRAQERKNEEMEVME------------- 168
E +E+E ++E + R RR + Q AQ + + E + +
Sbjct: 1851 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910
Query: 169 --VEDEGRSGEESESE-----SEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER-EAEAL 220
VED R + E E + +E+ + E+E L + +D + +E+ E EA
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970
Query: 221 KQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWK 280
+Q++L E +R RR+ + V++ E E ++ AAL +E E K
Sbjct: 1971 RQRQLAAEEER----RRREAEERVQKSLAAEEEAARQRKAAL---------EEVERLKAK 2017
Query: 281 VRELKRIKRDREDREALEKEKAEIERMRNLTEEER 315
V E +R++ E A + + A+ + L EE+
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2052
Score = 55.1 bits (131), Expect = 1e-07
Identities = 74/348 (21%), Positives = 148/348 (42%), Gaps = 55/348 (15%)
Query: 8 MKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPM-ESSDEEDEEFQFIKKA 66
M + +Q+ A ++ E + +K + + D M + EE + FQ
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ----- 2365
Query: 67 KEQEAEPEEQEEDSSSDPRLR-------RLQNRISEDVE----------ERLARHRKIVE 109
+ EAE + Q E S+ RL+ R Q R ED + E+L R +
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425
Query: 110 PEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV 169
+V E++ R + + +E E I + E E+ + + + K+EEM+ ++
Sbjct: 2426 EKVTLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2481
Query: 170 EDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER--EAEALKQKELEQ 227
E + +E+++ L+ F+ +KD + +ER E E K ++L Q
Sbjct: 2482 E---QLLQETQA-----------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2521
Query: 228 EAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRI 287
+ A++ R+ ++ ++++E+ ++ L A +++ EE K EL+++
Sbjct: 2522 DEVAKAQQLRE-----EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2576
Query: 288 KRD-REDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGK 334
++ R+ E L +E + L EE+ RA L + +V ++ K
Sbjct: 2577 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2624
Score = 52.8 bits (125), Expect = 6e-07
Identities = 76/355 (21%), Positives = 152/355 (42%), Gaps = 63/355 (17%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEF--QFIKKAKEQEAEPEEQ 76
A P + K + E V ++ YV R Y+ + + + +F + +++ +E+E E+Q
Sbjct: 1297 ASPAKKPKVQSGSESV-IQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG-DAWRMEREDSSEE 135
+ + R++E VE L + R++ E ++ +E E + + +E+
Sbjct: 1355 RAEE---------RERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 136 EEEEIDDEEIER---------------------RRGMMRQRAQERKNEEMEVMEVEDEGR 174
EE +D ++ +R R+ +R++ R EE+ V+ ++ E
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 175 SGEESESESEYEEYTDSEDEMEPRLKPV------FIRKKDRVTVQEREAEALKQKELEQE 228
+ +E E + +E E + + R+ + ++R+AE ++ E
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524
Query: 229 AKRMAEERRKY----TLKIVEEETKKELE--ENKRSLAALDALNTDDENDEEEYE----- 277
A+ E++R L++ EE ++ L E +R+ AL T + E E +
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1584
Query: 278 -AWKVRELKR--------IKRDREDREALEKEKAEIERMRNLTEEE-RRAELRAN 322
A K +L+R + + RE+ E +++AE ER R E E R +L+AN
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1639
Score = 50.1 bits (118), Expect = 4e-06
Identities = 61/311 (19%), Positives = 144/311 (46%), Gaps = 36/311 (11%)
Query: 58 EEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQ-------NRISEDVEERLARHRKIVEP 110
EE + +++ EQE+ + Q ++ RL+ + + +++++ L + + +++
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD- 2077
Query: 111 EVVGESD----SEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKN----- 161
++ GE++ + E + R++ E + + ++ EE ER + ++AQ R
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAA 2135
Query: 162 EEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRV-----TVQERE 216
E++ ++ R + ++ ++ D+E E + +R+K +V T++ +
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195
Query: 217 AEALKQKE-LEQEAKRM---AEERRKYTLKIVEE--ETKKELEENKRSLAALDALNTD-D 269
E QK L++E +R+ A E + ++ EE + ++EE + A ++A N
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255
Query: 270 ENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNK 329
D++ + + E +++K+ E+ L E R+R L EE+ A + + K
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEK 2310
Query: 330 AVKGKYKFLQK 340
+K K + +Q+
Sbjct: 2311 MLKEKMQAVQE 2321
Score = 48.1 bits (113), Expect = 2e-05
Identities = 75/349 (21%), Positives = 135/349 (38%), Gaps = 65/349 (18%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEP--EEQ 76
A R E +V+ +R + R E + EE + + AE +E
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEE 136
E++++ + + R + + + +H+K E + ++ E E R++ E++ +
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET--DH 2200
Query: 137 EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV--------------EDEGRS------- 175
++ + DEE++R + + A++R E E+ V E E R+
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2260
Query: 176 ------GEESESESEYEEYTD----------------SEDEMEPRLKPVFIRKKDRVTVQ 213
EE+E + E ED + R + K+ VQ
Sbjct: 2261 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2320
Query: 214 ER-----EAEALKQ-KELEQEAKRMAEERRKYTLKIVEEET---KKELEENKRSLAALDA 264
E EAE L+Q KEL QE R +E ++ + + EET ++ LE ++ + A
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 265 LNTDDENDEEEYEAWKVRELKRIK-RDREDREALEKEKAEIERMRNLTE 312
E E +V E+ R + R ED + K+ EI + TE
Sbjct: 2381 --------EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2421
Score = 42.0 bits (97), Expect = 0.001
Identities = 53/260 (20%), Positives = 115/260 (44%), Gaps = 24/260 (9%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVE-ERLARHRKIVEPEVVGESDSEVEG 122
++ +E AE E ++E + +L +L++ + V+ E+L + + ++ + E DS ++
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 123 DAWRMEREDSSEEE--EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESE 180
+ + +E+E + E+ ++E+ + + R RQ+ Q + + V +E+ R E+E
Sbjct: 2506 ERF-IEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563
Query: 181 SESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELE--QEAKRMAEERRK 238
E ++E++ ++ Q R+ E L +E + +E ++ EE+ +
Sbjct: 2564 -----EGVRRKQEELQ------------QLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606
Query: 239 YTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALE 298
L EE T ++ K DAL+ E E+ +R +R +E
Sbjct: 2607 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2666
Query: 299 KEKAEIERMRNLTEEERRAE 318
+E + + +E R E
Sbjct: 2667 EELQRLAQGHTTVDELARRE 2686
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 73.2 bits (178), Expect = 4e-13
Identities = 74/291 (25%), Positives = 130/291 (44%), Gaps = 36/291 (12%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERL-----ARHRKIVEPEVVGESDS 118
++ +Q+AE E E++ + L R Q + +E + RL A+ + + + E + +
Sbjct: 1579 ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE- 1635
Query: 119 EVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEE 178
E E +A R + + + E+ ++E+E++R + AQ+R E E++ + E GE+
Sbjct: 1636 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1695
Query: 179 SES---------ESEYEEYTDSEDEMEPRL------KPVFIRKKDRVTVQEREAEALKQK 223
+ E T E+E L V + K R + R ++
Sbjct: 1696 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1755
Query: 224 ELEQEAKR---MAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAW- 279
LE EA R +AEE + L+ + EE K++ R LA DA E + E
Sbjct: 1756 RLEAEAGRFRELAEEAAR--LRALAEEAKRQ-----RQLAEEDAARQRAEAERVLAEKLA 1808
Query: 280 KVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKA 330
+ E R+K + E AL++++AE ER+R L E+E R + +KA
Sbjct: 1809 AIGEATRLKTEAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1857
Score = 66.2 bits (160), Expect = 5e-11
Identities = 68/330 (20%), Positives = 138/330 (41%), Gaps = 22/330 (6%)
Query: 3 VPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQF 62
V +AL KQ + + E+ +++ + V + + EE Q
Sbjct: 1333 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1392
Query: 63 IKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG 122
++++ E E + + ++ +++ RLR +EE + R +E +E E
Sbjct: 1393 LRQSSEAEIQAKARQAEAAERSRLR---------IEEEIRVVRLQLEATERQRGGAEGEL 1443
Query: 123 DAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVME-VEDEGRSGEESES 181
A R E++ ++ + EE ER R ++ +Q ++ E+E+ V+ E + E +
Sbjct: 1444 QALRARAEEAEAQKRQA--QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1501
Query: 182 ESE-YEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYT 240
+ EE +E E RL+ + + +V V A+ + EL+ + AE+ +
Sbjct: 1502 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1561
Query: 241 LKIVEE-----ETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIK-RDREDR 294
+ EE + ++E E + A + E E E E W+++ + ++ R + +
Sbjct: 1562 RSLQEEHVAVAQLREEAERRAQQQAEAERAR---EEAERELERWQLKANEALRLRLQAEE 1618
Query: 295 EALEKEKAEIERMRNLTEEERRAELRANGK 324
A +K A+ E + E ER A R +
Sbjct: 1619 VAQQKSLAQAEAEKQKEEAEREARRRGKAE 1648
Score = 57.4 bits (137), Expect = 3e-08
Identities = 79/335 (23%), Positives = 137/335 (40%), Gaps = 53/335 (15%)
Query: 13 IQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAE 72
+Q A A + ++ E + KV+ + V ++ EE+ K + EAE
Sbjct: 1707 LQREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAE 1760
Query: 73 PEEQEEDSSSDPRLRRLQNRISED---VEERLARHRKIVEPEVVGESDSEVEGDAWRMER 129
E + RLR L EE AR R E V+ E + + G+A R++
Sbjct: 1761 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLAEKLAAI-GEATRLKT 1818
Query: 130 EDSSEEEEEEIDDEEIER--------RRGMMRQRAQERKNEEMEVME------------- 168
E +E+E ++E + R RR + Q AQ + + E + +
Sbjct: 1819 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1878
Query: 169 --VEDEGRSGEESESE-----SEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER-EAEAL 220
VED R + E E + +E+ + E+E L + +D + +E+ E EA
Sbjct: 1879 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1938
Query: 221 KQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWK 280
+Q++L E +R RR+ + V++ E E ++ AAL +E E K
Sbjct: 1939 RQRQLAAEEER----RRREAEERVQKSLAAEEEAARQRKAAL---------EEVERLKAK 1985
Query: 281 VRELKRIKRDREDREALEKEKAEIERMRNLTEEER 315
V E +R++ E A + + A+ + L EE+
Sbjct: 1986 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2020
Score = 55.1 bits (131), Expect = 1e-07
Identities = 74/348 (21%), Positives = 148/348 (42%), Gaps = 55/348 (15%)
Query: 8 MKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPM-ESSDEEDEEFQFIKKA 66
M + +Q+ A ++ E + +K + + D M + EE + FQ
Sbjct: 2279 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ----- 2333
Query: 67 KEQEAEPEEQEEDSSSDPRLR-------RLQNRISEDVE----------ERLARHRKIVE 109
+ EAE + Q E S+ RL+ R Q R ED + E+L R +
Sbjct: 2334 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2393
Query: 110 PEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV 169
+V E++ R + + +E E I + E E+ + + + K+EEM+ ++
Sbjct: 2394 EKVTLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2449
Query: 170 EDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER--EAEALKQKELEQ 227
E + +E+++ L+ F+ +KD + +ER E E K ++L Q
Sbjct: 2450 E---QLLQETQA-----------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2489
Query: 228 EAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRI 287
+ A++ R+ ++ ++++E+ ++ L A +++ EE K EL+++
Sbjct: 2490 DEVAKAQQLRE-----EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2544
Query: 288 KRD-REDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGK 334
++ R+ E L +E + L EE+ RA L + +V ++ K
Sbjct: 2545 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2592
Score = 52.8 bits (125), Expect = 6e-07
Identities = 76/355 (21%), Positives = 152/355 (42%), Gaps = 63/355 (17%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEF--QFIKKAKEQEAEPEEQ 76
A P + K + E V ++ YV R Y+ + + + +F + +++ +E+E E+Q
Sbjct: 1265 ASPAKKPKVQSGSESV-IQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1322
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG-DAWRMEREDSSEE 135
+ + R++E VE L + R++ E ++ +E E + + +E+
Sbjct: 1323 RAEE---------RERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1372
Query: 136 EEEEIDDEEIER---------------------RRGMMRQRAQERKNEEMEVMEVEDEGR 174
EE +D ++ +R R+ +R++ R EE+ V+ ++ E
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1432
Query: 175 SGEESESESEYEEYTDSEDEMEPRLKPV------FIRKKDRVTVQEREAEALKQKELEQE 228
+ +E E + +E E + + R+ + ++R+AE ++ E
Sbjct: 1433 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1492
Query: 229 AKRMAEERRKY----TLKIVEEETKKELE--ENKRSLAALDALNTDDENDEEEYE----- 277
A+ E++R L++ EE ++ L E +R+ AL T + E E +
Sbjct: 1493 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1552
Query: 278 -AWKVRELKR--------IKRDREDREALEKEKAEIERMRNLTEEE-RRAELRAN 322
A K +L+R + + RE+ E +++AE ER R E E R +L+AN
Sbjct: 1553 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1607
Score = 50.1 bits (118), Expect = 4e-06
Identities = 61/311 (19%), Positives = 144/311 (46%), Gaps = 36/311 (11%)
Query: 58 EEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQ-------NRISEDVEERLARHRKIVEP 110
EE + +++ EQE+ + Q ++ RL+ + + +++++ L + + +++
Sbjct: 1987 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD- 2045
Query: 111 EVVGESD----SEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKN----- 161
++ GE++ + E + R++ E + + ++ EE ER + ++AQ R
Sbjct: 2046 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAA 2103
Query: 162 EEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRV-----TVQERE 216
E++ ++ R + ++ ++ D+E E + +R+K +V T++ +
Sbjct: 2104 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2163
Query: 217 AEALKQKE-LEQEAKRM---AEERRKYTLKIVEE--ETKKELEENKRSLAALDALNTD-D 269
E QK L++E +R+ A E + ++ EE + ++EE + A ++A N
Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2223
Query: 270 ENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNK 329
D++ + + E +++K+ E+ L E R+R L EE+ A + + K
Sbjct: 2224 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEK 2278
Query: 330 AVKGKYKFLQK 340
+K K + +Q+
Sbjct: 2279 MLKEKMQAVQE 2289
Score = 48.1 bits (113), Expect = 2e-05
Identities = 75/349 (21%), Positives = 135/349 (38%), Gaps = 65/349 (18%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEP--EEQ 76
A R E +V+ +R + R E + EE + + AE +E
Sbjct: 2051 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2110
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEE 136
E++++ + + R + + + +H+K E + ++ E E R++ E++ +
Sbjct: 2111 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET--DH 2168
Query: 137 EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV--------------EDEGRS------- 175
++ + DEE++R + + A++R E E+ V E E R+
Sbjct: 2169 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2228
Query: 176 ------GEESESESEYEEYTD----------------SEDEMEPRLKPVFIRKKDRVTVQ 213
EE+E + E ED + R + K+ VQ
Sbjct: 2229 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2288
Query: 214 ER-----EAEALKQ-KELEQEAKRMAEERRKYTLKIVEEET---KKELEENKRSLAALDA 264
E EAE L+Q KEL QE R +E ++ + + EET ++ LE ++ + A
Sbjct: 2289 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2348
Query: 265 LNTDDENDEEEYEAWKVRELKRIK-RDREDREALEKEKAEIERMRNLTE 312
E E +V E+ R + R ED + K+ EI + TE
Sbjct: 2349 --------EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2389
Score = 42.0 bits (97), Expect = 0.001
Identities = 53/260 (20%), Positives = 115/260 (44%), Gaps = 24/260 (9%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVE-ERLARHRKIVEPEVVGESDSEVEG 122
++ +E AE E ++E + +L +L++ + V+ E+L + + ++ + E DS ++
Sbjct: 2414 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2473
Query: 123 DAWRMEREDSSEEE--EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESE 180
+ + +E+E + E+ ++E+ + + R RQ+ Q + + V +E+ R E+E
Sbjct: 2474 ERF-IEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2531
Query: 181 SESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELE--QEAKRMAEERRK 238
E ++E++ ++ Q R+ E L +E + +E ++ EE+ +
Sbjct: 2532 -----EGVRRKQEELQ------------QLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2574
Query: 239 YTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALE 298
L EE T ++ K DAL+ E E+ +R +R +E
Sbjct: 2575 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2634
Query: 299 KEKAEIERMRNLTEEERRAE 318
+E + + +E R E
Sbjct: 2635 EELQRLAQGHTTVDELARRE 2654
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 73.2 bits (178), Expect = 4e-13
Identities = 74/291 (25%), Positives = 130/291 (44%), Gaps = 36/291 (12%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERL-----ARHRKIVEPEVVGESDS 118
++ +Q+AE E E++ + L R Q + +E + RL A+ + + + E + +
Sbjct: 1748 ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE- 1804
Query: 119 EVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEE 178
E E +A R + + + E+ ++E+E++R + AQ+R E E++ + E GE+
Sbjct: 1805 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1864
Query: 179 SES---------ESEYEEYTDSEDEMEPRL------KPVFIRKKDRVTVQEREAEALKQK 223
+ E T E+E L V + K R + R ++
Sbjct: 1865 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1924
Query: 224 ELEQEAKR---MAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAW- 279
LE EA R +AEE + L+ + EE K++ R LA DA E + E
Sbjct: 1925 RLEAEAGRFRELAEEAAR--LRALAEEAKRQ-----RQLAEEDAARQRAEAERVLAEKLA 1977
Query: 280 KVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKA 330
+ E R+K + E AL++++AE ER+R L E+E R + +KA
Sbjct: 1978 AIGEATRLKTEAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 2026
Score = 66.2 bits (160), Expect = 5e-11
Identities = 68/330 (20%), Positives = 138/330 (41%), Gaps = 22/330 (6%)
Query: 3 VPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQF 62
V +AL KQ + + E+ +++ + V + + EE Q
Sbjct: 1502 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1561
Query: 63 IKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG 122
++++ E E + + ++ +++ RLR +EE + R +E +E E
Sbjct: 1562 LRQSSEAEIQAKARQAEAAERSRLR---------IEEEIRVVRLQLEATERQRGGAEGEL 1612
Query: 123 DAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVME-VEDEGRSGEESES 181
A R E++ ++ + EE ER R ++ +Q ++ E+E+ V+ E + E +
Sbjct: 1613 QALRARAEEAEAQKRQA--QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1670
Query: 182 ESE-YEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYT 240
+ EE +E E RL+ + + +V V A+ + EL+ + AE+ +
Sbjct: 1671 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730
Query: 241 LKIVEE-----ETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIK-RDREDR 294
+ EE + ++E E + A + E E E E W+++ + ++ R + +
Sbjct: 1731 RSLQEEHVAVAQLREEAERRAQQQAEAERAR---EEAERELERWQLKANEALRLRLQAEE 1787
Query: 295 EALEKEKAEIERMRNLTEEERRAELRANGK 324
A +K A+ E + E ER A R +
Sbjct: 1788 VAQQKSLAQAEAEKQKEEAEREARRRGKAE 1817
Score = 57.4 bits (137), Expect = 3e-08
Identities = 79/335 (23%), Positives = 137/335 (40%), Gaps = 53/335 (15%)
Query: 13 IQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAE 72
+Q A A + ++ E + KV+ + V ++ EE+ K + EAE
Sbjct: 1876 LQREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAE 1929
Query: 73 PEEQEEDSSSDPRLRRLQNRISED---VEERLARHRKIVEPEVVGESDSEVEGDAWRMER 129
E + RLR L EE AR R E V+ E + + G+A R++
Sbjct: 1930 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLAEKLAAI-GEATRLKT 1987
Query: 130 EDSSEEEEEEIDDEEIER--------RRGMMRQRAQERKNEEMEVME------------- 168
E +E+E ++E + R RR + Q AQ + + E + +
Sbjct: 1988 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 2047
Query: 169 --VEDEGRSGEESESE-----SEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER-EAEAL 220
VED R + E E + +E+ + E+E L + +D + +E+ E EA
Sbjct: 2048 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 2107
Query: 221 KQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWK 280
+Q++L E +R RR+ + V++ E E ++ AAL +E E K
Sbjct: 2108 RQRQLAAEEER----RRREAEERVQKSLAAEEEAARQRKAAL---------EEVERLKAK 2154
Query: 281 VRELKRIKRDREDREALEKEKAEIERMRNLTEEER 315
V E +R++ E A + + A+ + L EE+
Sbjct: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2189
Score = 55.1 bits (131), Expect = 1e-07
Identities = 74/348 (21%), Positives = 148/348 (42%), Gaps = 55/348 (15%)
Query: 8 MKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPM-ESSDEEDEEFQFIKKA 66
M + +Q+ A ++ E + +K + + D M + EE + FQ
Sbjct: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ----- 2502
Query: 67 KEQEAEPEEQEEDSSSDPRLR-------RLQNRISEDVE----------ERLARHRKIVE 109
+ EAE + Q E S+ RL+ R Q R ED + E+L R +
Sbjct: 2503 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2562
Query: 110 PEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV 169
+V E++ R + + +E E I + E E+ + + + K+EEM+ ++
Sbjct: 2563 EKVTLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2618
Query: 170 EDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER--EAEALKQKELEQ 227
E + +E+++ L+ F+ +KD + +ER E E K ++L Q
Sbjct: 2619 E---QLLQETQA-----------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2658
Query: 228 EAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRI 287
+ A++ R+ ++ ++++E+ ++ L A +++ EE K EL+++
Sbjct: 2659 DEVAKAQQLRE-----EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2713
Query: 288 KRD-REDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGK 334
++ R+ E L +E + L EE+ RA L + +V ++ K
Sbjct: 2714 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2761
Score = 52.8 bits (125), Expect = 6e-07
Identities = 76/355 (21%), Positives = 152/355 (42%), Gaps = 63/355 (17%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEF--QFIKKAKEQEAEPEEQ 76
A P + K + E V ++ YV R Y+ + + + +F + +++ +E+E E+Q
Sbjct: 1434 ASPAKKPKVQSGSESV-IQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1491
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG-DAWRMEREDSSEE 135
+ + R++E VE L + R++ E ++ +E E + + +E+
Sbjct: 1492 RAEE---------RERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1541
Query: 136 EEEEIDDEEIER---------------------RRGMMRQRAQERKNEEMEVMEVEDEGR 174
EE +D ++ +R R+ +R++ R EE+ V+ ++ E
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1601
Query: 175 SGEESESESEYEEYTDSEDEMEPRLKPV------FIRKKDRVTVQEREAEALKQKELEQE 228
+ +E E + +E E + + R+ + ++R+AE ++ E
Sbjct: 1602 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1661
Query: 229 AKRMAEERRKY----TLKIVEEETKKELE--ENKRSLAALDALNTDDENDEEEYE----- 277
A+ E++R L++ EE ++ L E +R+ AL T + E E +
Sbjct: 1662 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1721
Query: 278 -AWKVRELKR--------IKRDREDREALEKEKAEIERMRNLTEEE-RRAELRAN 322
A K +L+R + + RE+ E +++AE ER R E E R +L+AN
Sbjct: 1722 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1776
Score = 50.1 bits (118), Expect = 4e-06
Identities = 61/311 (19%), Positives = 144/311 (46%), Gaps = 36/311 (11%)
Query: 58 EEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQ-------NRISEDVEERLARHRKIVEP 110
EE + +++ EQE+ + Q ++ RL+ + + +++++ L + + +++
Sbjct: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD- 2214
Query: 111 EVVGESD----SEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKN----- 161
++ GE++ + E + R++ E + + ++ EE ER + ++AQ R
Sbjct: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAA 2272
Query: 162 EEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRV-----TVQERE 216
E++ ++ R + ++ ++ D+E E + +R+K +V T++ +
Sbjct: 2273 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2332
Query: 217 AEALKQKE-LEQEAKRM---AEERRKYTLKIVEE--ETKKELEENKRSLAALDALNTD-D 269
E QK L++E +R+ A E + ++ EE + ++EE + A ++A N
Sbjct: 2333 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2392
Query: 270 ENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNK 329
D++ + + E +++K+ E+ L E R+R L EE+ A + + K
Sbjct: 2393 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEK 2447
Query: 330 AVKGKYKFLQK 340
+K K + +Q+
Sbjct: 2448 MLKEKMQAVQE 2458
Score = 48.1 bits (113), Expect = 2e-05
Identities = 75/349 (21%), Positives = 135/349 (38%), Gaps = 65/349 (18%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEP--EEQ 76
A R E +V+ +R + R E + EE + + AE +E
Sbjct: 2220 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2279
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEE 136
E++++ + + R + + + +H+K E + ++ E E R++ E++ +
Sbjct: 2280 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET--DH 2337
Query: 137 EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV--------------EDEGRS------- 175
++ + DEE++R + + A++R E E+ V E E R+
Sbjct: 2338 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2397
Query: 176 ------GEESESESEYEEYTD----------------SEDEMEPRLKPVFIRKKDRVTVQ 213
EE+E + E ED + R + K+ VQ
Sbjct: 2398 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2457
Query: 214 ER-----EAEALKQ-KELEQEAKRMAEERRKYTLKIVEEET---KKELEENKRSLAALDA 264
E EAE L+Q KEL QE R +E ++ + + EET ++ LE ++ + A
Sbjct: 2458 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2517
Query: 265 LNTDDENDEEEYEAWKVRELKRIK-RDREDREALEKEKAEIERMRNLTE 312
E E +V E+ R + R ED + K+ EI + TE
Sbjct: 2518 --------EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2558
Score = 42.0 bits (97), Expect = 0.001
Identities = 53/260 (20%), Positives = 115/260 (44%), Gaps = 24/260 (9%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVE-ERLARHRKIVEPEVVGESDSEVEG 122
++ +E AE E ++E + +L +L++ + V+ E+L + + ++ + E DS ++
Sbjct: 2583 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2642
Query: 123 DAWRMEREDSSEEE--EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESE 180
+ + +E+E + E+ ++E+ + + R RQ+ Q + + V +E+ R E+E
Sbjct: 2643 ERF-IEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2700
Query: 181 SESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELE--QEAKRMAEERRK 238
E ++E++ ++ Q R+ E L +E + +E ++ EE+ +
Sbjct: 2701 -----EGVRRKQEELQ------------QLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2743
Query: 239 YTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALE 298
L EE T ++ K DAL+ E E+ +R +R +E
Sbjct: 2744 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2803
Query: 299 KEKAEIERMRNLTEEERRAE 318
+E + + +E R E
Sbjct: 2804 EELQRLAQGHTTVDELARRE 2823
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 73.2 bits (178), Expect = 4e-13
Identities = 74/291 (25%), Positives = 130/291 (44%), Gaps = 36/291 (12%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERL-----ARHRKIVEPEVVGESDS 118
++ +Q+AE E E++ + L R Q + +E + RL A+ + + + E + +
Sbjct: 1589 ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE- 1645
Query: 119 EVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEE 178
E E +A R + + + E+ ++E+E++R + AQ+R E E++ + E GE+
Sbjct: 1646 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1705
Query: 179 SES---------ESEYEEYTDSEDEMEPRL------KPVFIRKKDRVTVQEREAEALKQK 223
+ E T E+E L V + K R + R ++
Sbjct: 1706 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1765
Query: 224 ELEQEAKR---MAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAW- 279
LE EA R +AEE + L+ + EE K++ R LA DA E + E
Sbjct: 1766 RLEAEAGRFRELAEEAAR--LRALAEEAKRQ-----RQLAEEDAARQRAEAERVLAEKLA 1818
Query: 280 KVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKA 330
+ E R+K + E AL++++AE ER+R L E+E R + +KA
Sbjct: 1819 AIGEATRLKTEAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1867
Score = 66.2 bits (160), Expect = 5e-11
Identities = 68/330 (20%), Positives = 138/330 (41%), Gaps = 22/330 (6%)
Query: 3 VPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQF 62
V +AL KQ + + E+ +++ + V + + EE Q
Sbjct: 1343 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1402
Query: 63 IKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG 122
++++ E E + + ++ +++ RLR +EE + R +E +E E
Sbjct: 1403 LRQSSEAEIQAKARQAEAAERSRLR---------IEEEIRVVRLQLEATERQRGGAEGEL 1453
Query: 123 DAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVME-VEDEGRSGEESES 181
A R E++ ++ + EE ER R ++ +Q ++ E+E+ V+ E + E +
Sbjct: 1454 QALRARAEEAEAQKRQA--QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1511
Query: 182 ESE-YEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYT 240
+ EE +E E RL+ + + +V V A+ + EL+ + AE+ +
Sbjct: 1512 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571
Query: 241 LKIVEE-----ETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIK-RDREDR 294
+ EE + ++E E + A + E E E E W+++ + ++ R + +
Sbjct: 1572 RSLQEEHVAVAQLREEAERRAQQQAEAERAR---EEAERELERWQLKANEALRLRLQAEE 1628
Query: 295 EALEKEKAEIERMRNLTEEERRAELRANGK 324
A +K A+ E + E ER A R +
Sbjct: 1629 VAQQKSLAQAEAEKQKEEAEREARRRGKAE 1658
Score = 57.4 bits (137), Expect = 3e-08
Identities = 79/335 (23%), Positives = 137/335 (40%), Gaps = 53/335 (15%)
Query: 13 IQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAE 72
+Q A A + ++ E + KV+ + V ++ EE+ K + EAE
Sbjct: 1717 LQREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAE 1770
Query: 73 PEEQEEDSSSDPRLRRLQNRISED---VEERLARHRKIVEPEVVGESDSEVEGDAWRMER 129
E + RLR L EE AR R E V+ E + + G+A R++
Sbjct: 1771 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLAEKLAAI-GEATRLKT 1828
Query: 130 EDSSEEEEEEIDDEEIER--------RRGMMRQRAQERKNEEMEVME------------- 168
E +E+E ++E + R RR + Q AQ + + E + +
Sbjct: 1829 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1888
Query: 169 --VEDEGRSGEESESE-----SEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER-EAEAL 220
VED R + E E + +E+ + E+E L + +D + +E+ E EA
Sbjct: 1889 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1948
Query: 221 KQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWK 280
+Q++L E +R RR+ + V++ E E ++ AAL +E E K
Sbjct: 1949 RQRQLAAEEER----RRREAEERVQKSLAAEEEAARQRKAAL---------EEVERLKAK 1995
Query: 281 VRELKRIKRDREDREALEKEKAEIERMRNLTEEER 315
V E +R++ E A + + A+ + L EE+
Sbjct: 1996 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2030
Score = 55.1 bits (131), Expect = 1e-07
Identities = 74/348 (21%), Positives = 148/348 (42%), Gaps = 55/348 (15%)
Query: 8 MKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPM-ESSDEEDEEFQFIKKA 66
M + +Q+ A ++ E + +K + + D M + EE + FQ
Sbjct: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ----- 2343
Query: 67 KEQEAEPEEQEEDSSSDPRLR-------RLQNRISEDVE----------ERLARHRKIVE 109
+ EAE + Q E S+ RL+ R Q R ED + E+L R +
Sbjct: 2344 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2403
Query: 110 PEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV 169
+V E++ R + + +E E I + E E+ + + + K+EEM+ ++
Sbjct: 2404 EKVTLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2459
Query: 170 EDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER--EAEALKQKELEQ 227
E + +E+++ L+ F+ +KD + +ER E E K ++L Q
Sbjct: 2460 E---QLLQETQA-----------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2499
Query: 228 EAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRI 287
+ A++ R+ ++ ++++E+ ++ L A +++ EE K EL+++
Sbjct: 2500 DEVAKAQQLRE-----EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2554
Query: 288 KRD-REDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGK 334
++ R+ E L +E + L EE+ RA L + +V ++ K
Sbjct: 2555 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2602
Score = 52.8 bits (125), Expect = 6e-07
Identities = 76/355 (21%), Positives = 152/355 (42%), Gaps = 63/355 (17%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEF--QFIKKAKEQEAEPEEQ 76
A P + K + E V ++ YV R Y+ + + + +F + +++ +E+E E+Q
Sbjct: 1275 ASPAKKPKVQSGSESV-IQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1332
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG-DAWRMEREDSSEE 135
+ + R++E VE L + R++ E ++ +E E + + +E+
Sbjct: 1333 RAEE---------RERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1382
Query: 136 EEEEIDDEEIER---------------------RRGMMRQRAQERKNEEMEVMEVEDEGR 174
EE +D ++ +R R+ +R++ R EE+ V+ ++ E
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1442
Query: 175 SGEESESESEYEEYTDSEDEMEPRLKPV------FIRKKDRVTVQEREAEALKQKELEQE 228
+ +E E + +E E + + R+ + ++R+AE ++ E
Sbjct: 1443 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1502
Query: 229 AKRMAEERRKY----TLKIVEEETKKELE--ENKRSLAALDALNTDDENDEEEYE----- 277
A+ E++R L++ EE ++ L E +R+ AL T + E E +
Sbjct: 1503 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1562
Query: 278 -AWKVRELKR--------IKRDREDREALEKEKAEIERMRNLTEEE-RRAELRAN 322
A K +L+R + + RE+ E +++AE ER R E E R +L+AN
Sbjct: 1563 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1617
Score = 50.1 bits (118), Expect = 4e-06
Identities = 61/311 (19%), Positives = 144/311 (46%), Gaps = 36/311 (11%)
Query: 58 EEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQ-------NRISEDVEERLARHRKIVEP 110
EE + +++ EQE+ + Q ++ RL+ + + +++++ L + + +++
Sbjct: 1997 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD- 2055
Query: 111 EVVGESD----SEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKN----- 161
++ GE++ + E + R++ E + + ++ EE ER + ++AQ R
Sbjct: 2056 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAA 2113
Query: 162 EEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRV-----TVQERE 216
E++ ++ R + ++ ++ D+E E + +R+K +V T++ +
Sbjct: 2114 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2173
Query: 217 AEALKQKE-LEQEAKRM---AEERRKYTLKIVEE--ETKKELEENKRSLAALDALNTD-D 269
E QK L++E +R+ A E + ++ EE + ++EE + A ++A N
Sbjct: 2174 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2233
Query: 270 ENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNK 329
D++ + + E +++K+ E+ L E R+R L EE+ A + + K
Sbjct: 2234 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEK 2288
Query: 330 AVKGKYKFLQK 340
+K K + +Q+
Sbjct: 2289 MLKEKMQAVQE 2299
Score = 48.1 bits (113), Expect = 2e-05
Identities = 75/349 (21%), Positives = 135/349 (38%), Gaps = 65/349 (18%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEP--EEQ 76
A R E +V+ +R + R E + EE + + AE +E
Sbjct: 2061 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2120
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEE 136
E++++ + + R + + + +H+K E + ++ E E R++ E++ +
Sbjct: 2121 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET--DH 2178
Query: 137 EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV--------------EDEGRS------- 175
++ + DEE++R + + A++R E E+ V E E R+
Sbjct: 2179 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2238
Query: 176 ------GEESESESEYEEYTD----------------SEDEMEPRLKPVFIRKKDRVTVQ 213
EE+E + E ED + R + K+ VQ
Sbjct: 2239 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2298
Query: 214 ER-----EAEALKQ-KELEQEAKRMAEERRKYTLKIVEEET---KKELEENKRSLAALDA 264
E EAE L+Q KEL QE R +E ++ + + EET ++ LE ++ + A
Sbjct: 2299 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2358
Query: 265 LNTDDENDEEEYEAWKVRELKRIK-RDREDREALEKEKAEIERMRNLTE 312
E E +V E+ R + R ED + K+ EI + TE
Sbjct: 2359 --------EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2399
Score = 42.0 bits (97), Expect = 0.001
Identities = 53/260 (20%), Positives = 115/260 (44%), Gaps = 24/260 (9%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVE-ERLARHRKIVEPEVVGESDSEVEG 122
++ +E AE E ++E + +L +L++ + V+ E+L + + ++ + E DS ++
Sbjct: 2424 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2483
Query: 123 DAWRMEREDSSEEE--EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESE 180
+ + +E+E + E+ ++E+ + + R RQ+ Q + + V +E+ R E+E
Sbjct: 2484 ERF-IEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2541
Query: 181 SESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELE--QEAKRMAEERRK 238
E ++E++ ++ Q R+ E L +E + +E ++ EE+ +
Sbjct: 2542 -----EGVRRKQEELQ------------QLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2584
Query: 239 YTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALE 298
L EE T ++ K DAL+ E E+ +R +R +E
Sbjct: 2585 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2644
Query: 299 KEKAEIERMRNLTEEERRAE 318
+E + + +E R E
Sbjct: 2645 EELQRLAQGHTTVDELARRE 2664
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 73.2 bits (178), Expect = 4e-13
Identities = 74/291 (25%), Positives = 130/291 (44%), Gaps = 36/291 (12%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERL-----ARHRKIVEPEVVGESDS 118
++ +Q+AE E E++ + L R Q + +E + RL A+ + + + E + +
Sbjct: 1597 ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE- 1653
Query: 119 EVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEE 178
E E +A R + + + E+ ++E+E++R + AQ+R E E++ + E GE+
Sbjct: 1654 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1713
Query: 179 SES---------ESEYEEYTDSEDEMEPRL------KPVFIRKKDRVTVQEREAEALKQK 223
+ E T E+E L V + K R + R ++
Sbjct: 1714 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1773
Query: 224 ELEQEAKR---MAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAW- 279
LE EA R +AEE + L+ + EE K++ R LA DA E + E
Sbjct: 1774 RLEAEAGRFRELAEEAAR--LRALAEEAKRQ-----RQLAEEDAARQRAEAERVLAEKLA 1826
Query: 280 KVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKA 330
+ E R+K + E AL++++AE ER+R L E+E R + +KA
Sbjct: 1827 AIGEATRLKTEAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1875
Score = 66.2 bits (160), Expect = 5e-11
Identities = 68/330 (20%), Positives = 138/330 (41%), Gaps = 22/330 (6%)
Query: 3 VPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQF 62
V +AL KQ + + E+ +++ + V + + EE Q
Sbjct: 1351 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1410
Query: 63 IKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG 122
++++ E E + + ++ +++ RLR +EE + R +E +E E
Sbjct: 1411 LRQSSEAEIQAKARQAEAAERSRLR---------IEEEIRVVRLQLEATERQRGGAEGEL 1461
Query: 123 DAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVME-VEDEGRSGEESES 181
A R E++ ++ + EE ER R ++ +Q ++ E+E+ V+ E + E +
Sbjct: 1462 QALRARAEEAEAQKRQA--QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1519
Query: 182 ESE-YEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYT 240
+ EE +E E RL+ + + +V V A+ + EL+ + AE+ +
Sbjct: 1520 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1579
Query: 241 LKIVEE-----ETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIK-RDREDR 294
+ EE + ++E E + A + E E E E W+++ + ++ R + +
Sbjct: 1580 RSLQEEHVAVAQLREEAERRAQQQAEAERAR---EEAERELERWQLKANEALRLRLQAEE 1636
Query: 295 EALEKEKAEIERMRNLTEEERRAELRANGK 324
A +K A+ E + E ER A R +
Sbjct: 1637 VAQQKSLAQAEAEKQKEEAEREARRRGKAE 1666
Score = 57.4 bits (137), Expect = 3e-08
Identities = 79/335 (23%), Positives = 137/335 (40%), Gaps = 53/335 (15%)
Query: 13 IQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAE 72
+Q A A + ++ E + KV+ + V ++ EE+ K + EAE
Sbjct: 1725 LQREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAE 1778
Query: 73 PEEQEEDSSSDPRLRRLQNRISED---VEERLARHRKIVEPEVVGESDSEVEGDAWRMER 129
E + RLR L EE AR R E V+ E + + G+A R++
Sbjct: 1779 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLAEKLAAI-GEATRLKT 1836
Query: 130 EDSSEEEEEEIDDEEIER--------RRGMMRQRAQERKNEEMEVME------------- 168
E +E+E ++E + R RR + Q AQ + + E + +
Sbjct: 1837 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1896
Query: 169 --VEDEGRSGEESESE-----SEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER-EAEAL 220
VED R + E E + +E+ + E+E L + +D + +E+ E EA
Sbjct: 1897 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1956
Query: 221 KQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWK 280
+Q++L E +R RR+ + V++ E E ++ AAL +E E K
Sbjct: 1957 RQRQLAAEEER----RRREAEERVQKSLAAEEEAARQRKAAL---------EEVERLKAK 2003
Query: 281 VRELKRIKRDREDREALEKEKAEIERMRNLTEEER 315
V E +R++ E A + + A+ + L EE+
Sbjct: 2004 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2038
Score = 55.1 bits (131), Expect = 1e-07
Identities = 74/348 (21%), Positives = 148/348 (42%), Gaps = 55/348 (15%)
Query: 8 MKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPM-ESSDEEDEEFQFIKKA 66
M + +Q+ A ++ E + +K + + D M + EE + FQ
Sbjct: 2297 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ----- 2351
Query: 67 KEQEAEPEEQEEDSSSDPRLR-------RLQNRISEDVE----------ERLARHRKIVE 109
+ EAE + Q E S+ RL+ R Q R ED + E+L R +
Sbjct: 2352 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2411
Query: 110 PEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV 169
+V E++ R + + +E E I + E E+ + + + K+EEM+ ++
Sbjct: 2412 EKVTLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2467
Query: 170 EDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER--EAEALKQKELEQ 227
E + +E+++ L+ F+ +KD + +ER E E K ++L Q
Sbjct: 2468 E---QLLQETQA-----------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2507
Query: 228 EAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRI 287
+ A++ R+ ++ ++++E+ ++ L A +++ EE K EL+++
Sbjct: 2508 DEVAKAQQLRE-----EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2562
Query: 288 KRD-REDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGK 334
++ R+ E L +E + L EE+ RA L + +V ++ K
Sbjct: 2563 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2610
Score = 52.8 bits (125), Expect = 6e-07
Identities = 76/355 (21%), Positives = 152/355 (42%), Gaps = 63/355 (17%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEF--QFIKKAKEQEAEPEEQ 76
A P + K + E V ++ YV R Y+ + + + +F + +++ +E+E E+Q
Sbjct: 1283 ASPAKKPKVQSGSESV-IQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1340
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG-DAWRMEREDSSEE 135
+ + R++E VE L + R++ E ++ +E E + + +E+
Sbjct: 1341 RAEE---------RERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1390
Query: 136 EEEEIDDEEIER---------------------RRGMMRQRAQERKNEEMEVMEVEDEGR 174
EE +D ++ +R R+ +R++ R EE+ V+ ++ E
Sbjct: 1391 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1450
Query: 175 SGEESESESEYEEYTDSEDEMEPRLKPV------FIRKKDRVTVQEREAEALKQKELEQE 228
+ +E E + +E E + + R+ + ++R+AE ++ E
Sbjct: 1451 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1510
Query: 229 AKRMAEERRKY----TLKIVEEETKKELE--ENKRSLAALDALNTDDENDEEEYE----- 277
A+ E++R L++ EE ++ L E +R+ AL T + E E +
Sbjct: 1511 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1570
Query: 278 -AWKVRELKR--------IKRDREDREALEKEKAEIERMRNLTEEE-RRAELRAN 322
A K +L+R + + RE+ E +++AE ER R E E R +L+AN
Sbjct: 1571 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1625
Score = 50.1 bits (118), Expect = 4e-06
Identities = 61/311 (19%), Positives = 144/311 (46%), Gaps = 36/311 (11%)
Query: 58 EEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQ-------NRISEDVEERLARHRKIVEP 110
EE + +++ EQE+ + Q ++ RL+ + + +++++ L + + +++
Sbjct: 2005 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD- 2063
Query: 111 EVVGESD----SEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKN----- 161
++ GE++ + E + R++ E + + ++ EE ER + ++AQ R
Sbjct: 2064 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAA 2121
Query: 162 EEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRV-----TVQERE 216
E++ ++ R + ++ ++ D+E E + +R+K +V T++ +
Sbjct: 2122 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2181
Query: 217 AEALKQKE-LEQEAKRM---AEERRKYTLKIVEE--ETKKELEENKRSLAALDALNTD-D 269
E QK L++E +R+ A E + ++ EE + ++EE + A ++A N
Sbjct: 2182 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2241
Query: 270 ENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNK 329
D++ + + E +++K+ E+ L E R+R L EE+ A + + K
Sbjct: 2242 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEK 2296
Query: 330 AVKGKYKFLQK 340
+K K + +Q+
Sbjct: 2297 MLKEKMQAVQE 2307
Score = 48.1 bits (113), Expect = 2e-05
Identities = 75/349 (21%), Positives = 135/349 (38%), Gaps = 65/349 (18%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEP--EEQ 76
A R E +V+ +R + R E + EE + + AE +E
Sbjct: 2069 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2128
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEE 136
E++++ + + R + + + +H+K E + ++ E E R++ E++ +
Sbjct: 2129 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET--DH 2186
Query: 137 EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV--------------EDEGRS------- 175
++ + DEE++R + + A++R E E+ V E E R+
Sbjct: 2187 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2246
Query: 176 ------GEESESESEYEEYTD----------------SEDEMEPRLKPVFIRKKDRVTVQ 213
EE+E + E ED + R + K+ VQ
Sbjct: 2247 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2306
Query: 214 ER-----EAEALKQ-KELEQEAKRMAEERRKYTLKIVEEET---KKELEENKRSLAALDA 264
E EAE L+Q KEL QE R +E ++ + + EET ++ LE ++ + A
Sbjct: 2307 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2366
Query: 265 LNTDDENDEEEYEAWKVRELKRIK-RDREDREALEKEKAEIERMRNLTE 312
E E +V E+ R + R ED + K+ EI + TE
Sbjct: 2367 --------EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2407
Score = 42.0 bits (97), Expect = 0.001
Identities = 53/260 (20%), Positives = 115/260 (44%), Gaps = 24/260 (9%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVE-ERLARHRKIVEPEVVGESDSEVEG 122
++ +E AE E ++E + +L +L++ + V+ E+L + + ++ + E DS ++
Sbjct: 2432 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2491
Query: 123 DAWRMEREDSSEEE--EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESE 180
+ + +E+E + E+ ++E+ + + R RQ+ Q + + V +E+ R E+E
Sbjct: 2492 ERF-IEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2549
Query: 181 SESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELE--QEAKRMAEERRK 238
E ++E++ ++ Q R+ E L +E + +E ++ EE+ +
Sbjct: 2550 -----EGVRRKQEELQ------------QLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2592
Query: 239 YTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALE 298
L EE T ++ K DAL+ E E+ +R +R +E
Sbjct: 2593 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2652
Query: 299 KEKAEIERMRNLTEEERRAE 318
+E + + +E R E
Sbjct: 2653 EELQRLAQGHTTVDELARRE 2672
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 73.2 bits (178), Expect = 4e-13
Identities = 74/291 (25%), Positives = 130/291 (44%), Gaps = 36/291 (12%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERL-----ARHRKIVEPEVVGESDS 118
++ +Q+AE E E++ + L R Q + +E + RL A+ + + + E + +
Sbjct: 1638 ERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE- 1694
Query: 119 EVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEE 178
E E +A R + + + E+ ++E+E++R + AQ+R E E++ + E GE+
Sbjct: 1695 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1754
Query: 179 SES---------ESEYEEYTDSEDEMEPRL------KPVFIRKKDRVTVQEREAEALKQK 223
+ E T E+E L V + K R + R ++
Sbjct: 1755 QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1814
Query: 224 ELEQEAKR---MAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAW- 279
LE EA R +AEE + L+ + EE K++ R LA DA E + E
Sbjct: 1815 RLEAEAGRFRELAEEAAR--LRALAEEAKRQ-----RQLAEEDAARQRAEAERVLAEKLA 1867
Query: 280 KVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKA 330
+ E R+K + E AL++++AE ER+R L E+E R + +KA
Sbjct: 1868 AIGEATRLKTEAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1916
Score = 66.2 bits (160), Expect = 5e-11
Identities = 68/330 (20%), Positives = 138/330 (41%), Gaps = 22/330 (6%)
Query: 3 VPSALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQF 62
V +AL KQ + + E+ +++ + V + + EE Q
Sbjct: 1392 VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1451
Query: 63 IKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG 122
++++ E E + + ++ +++ RLR +EE + R +E +E E
Sbjct: 1452 LRQSSEAEIQAKARQAEAAERSRLR---------IEEEIRVVRLQLEATERQRGGAEGEL 1502
Query: 123 DAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVME-VEDEGRSGEESES 181
A R E++ ++ + EE ER R ++ +Q ++ E+E+ V+ E + E +
Sbjct: 1503 QALRARAEEAEAQKRQA--QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1560
Query: 182 ESE-YEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYT 240
+ EE +E E RL+ + + +V V A+ + EL+ + AE+ +
Sbjct: 1561 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620
Query: 241 LKIVEE-----ETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIK-RDREDR 294
+ EE + ++E E + A + E E E E W+++ + ++ R + +
Sbjct: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAR---EEAERELERWQLKANEALRLRLQAEE 1677
Query: 295 EALEKEKAEIERMRNLTEEERRAELRANGK 324
A +K A+ E + E ER A R +
Sbjct: 1678 VAQQKSLAQAEAEKQKEEAEREARRRGKAE 1707
Score = 57.4 bits (137), Expect = 3e-08
Identities = 79/335 (23%), Positives = 137/335 (40%), Gaps = 53/335 (15%)
Query: 13 IQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAE 72
+Q A A + ++ E + KV+ + V ++ EE+ K + EAE
Sbjct: 1766 LQREAAAATQKRQELEAELAKVRAEMEV------LLASKARAEEESRSTSEKSKQRLEAE 1819
Query: 73 PEEQEEDSSSDPRLRRLQNRISED---VEERLARHRKIVEPEVVGESDSEVEGDAWRMER 129
E + RLR L EE AR R E V+ E + + G+A R++
Sbjct: 1820 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLAEKLAAI-GEATRLKT 1877
Query: 130 EDSSEEEEEEIDDEEIER--------RRGMMRQRAQERKNEEMEVME------------- 168
E +E+E ++E + R RR + Q AQ + + E + +
Sbjct: 1878 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1937
Query: 169 --VEDEGRSGEESESE-----SEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER-EAEAL 220
VED R + E E + +E+ + E+E L + +D + +E+ E EA
Sbjct: 1938 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1997
Query: 221 KQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWK 280
+Q++L E +R RR+ + V++ E E ++ AAL +E E K
Sbjct: 1998 RQRQLAAEEER----RRREAEERVQKSLAAEEEAARQRKAAL---------EEVERLKAK 2044
Query: 281 VRELKRIKRDREDREALEKEKAEIERMRNLTEEER 315
V E +R++ E A + + A+ + L EE+
Sbjct: 2045 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2079
Score = 55.1 bits (131), Expect = 1e-07
Identities = 74/348 (21%), Positives = 148/348 (42%), Gaps = 55/348 (15%)
Query: 8 MKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPM-ESSDEEDEEFQFIKKA 66
M + +Q+ A ++ E + +K + + D M + EE + FQ
Sbjct: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ----- 2392
Query: 67 KEQEAEPEEQEEDSSSDPRLR-------RLQNRISEDVE----------ERLARHRKIVE 109
+ EAE + Q E S+ RL+ R Q R ED + E+L R +
Sbjct: 2393 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2452
Query: 110 PEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV 169
+V E++ R + + +E E I + E E+ + + + K+EEM+ ++
Sbjct: 2453 EKVTLVQTLEIQ----RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2508
Query: 170 EDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQER--EAEALKQKELEQ 227
E + +E+++ L+ F+ +KD + +ER E E K ++L Q
Sbjct: 2509 E---QLLQETQA-----------------LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2548
Query: 228 EAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRI 287
+ A++ R+ ++ ++++E+ ++ L A +++ EE K EL+++
Sbjct: 2549 DEVAKAQQLRE-----EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2603
Query: 288 KRD-REDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGK 334
++ R+ E L +E + L EE+ RA L + +V ++ K
Sbjct: 2604 EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2651
Score = 52.8 bits (125), Expect = 6e-07
Identities = 76/355 (21%), Positives = 152/355 (42%), Gaps = 63/355 (17%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEF--QFIKKAKEQEAEPEEQ 76
A P + K + E V ++ YV R Y+ + + + +F + +++ +E+E E+Q
Sbjct: 1324 ASPAKKPKVQSGSESV-IQEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1381
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEG-DAWRMEREDSSEE 135
+ + R++E VE L + R++ E ++ +E E + + +E+
Sbjct: 1382 RAEE---------RERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1431
Query: 136 EEEEIDDEEIER---------------------RRGMMRQRAQERKNEEMEVMEVEDEGR 174
EE +D ++ +R R+ +R++ R EE+ V+ ++ E
Sbjct: 1432 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1491
Query: 175 SGEESESESEYEEYTDSEDEMEPRLKPV------FIRKKDRVTVQEREAEALKQKELEQE 228
+ +E E + +E E + + R+ + ++R+AE ++ E
Sbjct: 1492 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1551
Query: 229 AKRMAEERRKY----TLKIVEEETKKELE--ENKRSLAALDALNTDDENDEEEYE----- 277
A+ E++R L++ EE ++ L E +R+ AL T + E E +
Sbjct: 1552 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRAS 1611
Query: 278 -AWKVRELKR--------IKRDREDREALEKEKAEIERMRNLTEEE-RRAELRAN 322
A K +L+R + + RE+ E +++AE ER R E E R +L+AN
Sbjct: 1612 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1666
Score = 50.1 bits (118), Expect = 4e-06
Identities = 61/311 (19%), Positives = 144/311 (46%), Gaps = 36/311 (11%)
Query: 58 EEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQ-------NRISEDVEERLARHRKIVEP 110
EE + +++ EQE+ + Q ++ RL+ + + +++++ L + + +++
Sbjct: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD- 2104
Query: 111 EVVGESD----SEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKN----- 161
++ GE++ + E + R++ E + + ++ EE ER + ++AQ R
Sbjct: 2105 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV--EEAERLKQSAEEQAQARAQAQAAA 2162
Query: 162 EEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRV-----TVQERE 216
E++ ++ R + ++ ++ D+E E + +R+K +V T++ +
Sbjct: 2163 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2222
Query: 217 AEALKQKE-LEQEAKRM---AEERRKYTLKIVEE--ETKKELEENKRSLAALDALNTD-D 269
E QK L++E +R+ A E + ++ EE + ++EE + A ++A N
Sbjct: 2223 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2282
Query: 270 ENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNK 329
D++ + + E +++K+ E+ L E R+R L EE+ A + + K
Sbjct: 2283 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEK 2337
Query: 330 AVKGKYKFLQK 340
+K K + +Q+
Sbjct: 2338 MLKEKMQAVQE 2348
Score = 48.1 bits (113), Expect = 2e-05
Identities = 75/349 (21%), Positives = 135/349 (38%), Gaps = 65/349 (18%)
Query: 19 AVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEP--EEQ 76
A R E +V+ +R + R E + EE + + AE +E
Sbjct: 2110 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2169
Query: 77 EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEE 136
E++++ + + R + + + +H+K E + ++ E E R++ E++ +
Sbjct: 2170 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET--DH 2227
Query: 137 EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEV--------------EDEGRS------- 175
++ + DEE++R + + A++R E E+ V E E R+
Sbjct: 2228 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2287
Query: 176 ------GEESESESEYEEYTD----------------SEDEMEPRLKPVFIRKKDRVTVQ 213
EE+E + E ED + R + K+ VQ
Sbjct: 2288 NTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2347
Query: 214 ER-----EAEALKQ-KELEQEAKRMAEERRKYTLKIVEEET---KKELEENKRSLAALDA 264
E EAE L+Q KEL QE R +E ++ + + EET ++ LE ++ + A
Sbjct: 2348 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2407
Query: 265 LNTDDENDEEEYEAWKVRELKRIK-RDREDREALEKEKAEIERMRNLTE 312
E E +V E+ R + R ED + K+ EI + TE
Sbjct: 2408 --------EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2448
Score = 42.0 bits (97), Expect = 0.001
Identities = 53/260 (20%), Positives = 115/260 (44%), Gaps = 24/260 (9%)
Query: 64 KKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVE-ERLARHRKIVEPEVVGESDSEVEG 122
++ +E AE E ++E + +L +L++ + V+ E+L + + ++ + E DS ++
Sbjct: 2473 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2532
Query: 123 DAWRMEREDSSEEE--EEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESE 180
+ + +E+E + E+ ++E+ + + R RQ+ Q + + V +E+ R E+E
Sbjct: 2533 ERF-IEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2590
Query: 181 SESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELE--QEAKRMAEERRK 238
E ++E++ ++ Q R+ E L +E + +E ++ EE+ +
Sbjct: 2591 -----EGVRRKQEELQ------------QLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2633
Query: 239 YTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALE 298
L EE T ++ K DAL+ E E+ +R +R +E
Sbjct: 2634 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2693
Query: 299 KEKAEIERMRNLTEEERRAE 318
+E + + +E R E
Sbjct: 2694 EELQRLAQGHTTVDELARRE 2713
>gi|48255879 troponin T type 2, cardiac isoform 2 [Homo sapiens]
Length = 288
Score = 72.8 bits (177), Expect = 6e-13
Identities = 74/297 (24%), Positives = 139/297 (46%), Gaps = 35/297 (11%)
Query: 50 MESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRL--QNRISEDVEERLARHRKI 107
M +E EE++ + +++EA EEQEE + D + R ED EE A+
Sbjct: 1 MSDIEEVVEEYE---EEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAK---- 53
Query: 108 VEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRR---------GMMRQRAQE 158
E E +S+ + ++ + E +D ++I R+R ++ +
Sbjct: 54 -EAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFEN 112
Query: 159 RKNEEMEVMEVED--EGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQERE 216
RK EE E++ ++D E R E +E + E E E + RL R+++ ++ E
Sbjct: 113 RKKEEEELVSLKDRIERRRAERAEQQRIRNE---REKERQNRLAEERARREEEENRRKAE 169
Query: 217 AEALKQKELEQEA------KRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDE 270
EA K+K L ++ A+ RK + E E KK++ +R + A+D LN +D+
Sbjct: 170 DEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLN-EDQ 228
Query: 271 NDEEEYEAWKVRELKRIKRDRED-REALEKEKAEIERMRN-LTEEERRAELRANGKV 325
E+ E W + + ++ ++ D +E +++K EI +RN + + ++ ++ R KV
Sbjct: 229 LREKAKELW--QSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKV 283
>gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens]
Length = 282
Score = 71.6 bits (174), Expect = 1e-12
Identities = 73/294 (24%), Positives = 137/294 (46%), Gaps = 35/294 (11%)
Query: 50 MESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVE 109
M +E EE++ +EQE + E EED+ ++ + R ED EE A+ E
Sbjct: 1 MSDIEEVVEEYE----EEEQEEQEEAAEEDAEAEAETE--ETRAEEDEEEEEAK-----E 49
Query: 110 PEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRR---------GMMRQRAQERK 160
E +S+ + ++ + E +D ++I R+R ++ + RK
Sbjct: 50 AEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRK 109
Query: 161 NEEMEVMEVED--EGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAE 218
EE E++ ++D E R E +E + E E E + RL R+++ ++ E E
Sbjct: 110 KEEEELVSLKDRIERRRAERAEQQRIRNE---REKERQNRLAEERARREEEENRRKAEDE 166
Query: 219 ALKQKELEQEAK-----RMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDE 273
A K+K L + A+ RK + E E KK++ +R + A+D LN +D+ E
Sbjct: 167 ARKKKALSNMMHFGGYIQKAQTERKSGKRQTEREKKKKILAERRKVLAIDHLN-EDQLRE 225
Query: 274 EEYEAWKVRELKRIKRDRED-REALEKEKAEIERMRN-LTEEERRAELRANGKV 325
+ E W + + ++ ++ D +E +++K EI +RN + + ++ ++ R KV
Sbjct: 226 KAKELW--QSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKV 277
>gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens]
Length = 295
Score = 71.2 bits (173), Expect = 2e-12
Identities = 70/294 (23%), Positives = 138/294 (46%), Gaps = 29/294 (9%)
Query: 50 MESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRL--QNRISEDVEERLARHRKI 107
+E +EE++E +++ ++ + +EQEE + D + R ED EE A+
Sbjct: 8 VEEYEEEEQEEAAVEEEEDWREDEDEQEEAAEEDAEAEAETEETRAEEDEEEEEAK---- 63
Query: 108 VEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRR---------GMMRQRAQE 158
E E +S+ + ++ + E +D ++I R+R ++ +
Sbjct: 64 -EAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFEN 122
Query: 159 RKNEEMEVMEVED--EGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQERE 216
RK EE E++ ++D E R E +E + E E E + RL R+++ ++ E
Sbjct: 123 RKKEEEELVSLKDRIERRRAERAEQQRIRNE---REKERQNRLAEERARREEEENRRKAE 179
Query: 217 AEALKQKELEQEAK---RMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDE 273
EA K+K L + + RK + E E KK++ +R + A+D LN +D+ E
Sbjct: 180 DEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLN-EDQLRE 238
Query: 274 EEYEAWKVRELKRIKRDRED-REALEKEKAEIERMRN-LTEEERRAELRANGKV 325
+ E W + + ++ ++ D +E +++K EI +RN + + ++ ++ R KV
Sbjct: 239 KAKELW--QSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKV 290
Score = 50.8 bits (120), Expect = 2e-06
Identities = 65/251 (25%), Positives = 102/251 (40%), Gaps = 51/251 (20%)
Query: 111 EVVGESDSEVEGDAWRMERED--SSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVME 168
EVV E + E + +A E ED E+E+EE +E+ E RA+E + EE E E
Sbjct: 6 EVVEEYEEEEQEEAAVEEEEDWREDEDEQEEAAEEDAEAEAETEETRAEEDEEEE-EAKE 64
Query: 169 VEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQE 228
ED G ES+ + + P L P I +RV + + + +K +E++
Sbjct: 65 AED----GPMEESKPKPRSFM-------PNLVPPKIPDGERV-----DFDDIHRKRMEKD 108
Query: 229 AKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVR-ELKRI 287
+ A ++A + + +EEE + K R E +R
Sbjct: 109 LNELQ--------------------------ALIEAHFENRKKEEEELVSLKDRIERRRA 142
Query: 288 KRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAF 347
+R + R E+EK ER L EE R E N + ++A K K L H G +
Sbjct: 143 ERAEQQRIRNEREK---ERQNRLAEERARREEEENRRKAEDEA--RKKKALSNMMHFGGY 197
Query: 348 FMDEDEEVYKR 358
+ + KR
Sbjct: 198 IQKTERKSGKR 208
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 70.9 bits (172), Expect = 2e-12
Identities = 83/310 (26%), Positives = 147/310 (47%), Gaps = 45/310 (14%)
Query: 28 EISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLR 87
EI M K+K +V +R +E S + +E+ F E++ E + + +L
Sbjct: 2094 EIKMTKMKRALFVKERR---LSIEQSKLDIKEWDF----------SEKRSELTKDEKKLA 2140
Query: 88 RLQNRISEDVEERLARHRKIVEPEV-VGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIE 146
R Q +++ + + + K+ E E + SEV D + E+ EEEE I +
Sbjct: 2141 RKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILD----DEEEGGIEEEEVIPFLKRR 2196
Query: 147 RRRGMMRQRAQERKNE-EMEVMEVEDEGRSGEESES---ESEYEEYTDSEDEMEPRLKPV 202
R+ +R + K + +V EVE E EE ES E E +E SE+E E +
Sbjct: 2197 WRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEE-- 2254
Query: 203 FIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAAL 262
+++ V+E E E +++E E++ EE +K K +E+ K+E++E +
Sbjct: 2255 --EEREEEEVREEEEERKEEEEGEEKQVEKEEEEKK---KKKKEKKKEEVQEKEEVFEEK 2309
Query: 263 DALNTDDE----ND-EEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRA 317
+ + +++E +D EEE E+ + E + DRE +E L+KEK + +E+RR
Sbjct: 2310 EEIMSEEETESLSDEEEEEESCSLEE----EVDRE-KEILKKEK------QFKLQEQRRK 2358
Query: 318 ELRANGKVIT 327
LR +V++
Sbjct: 2359 SLRGRERVLS 2368
Score = 62.0 bits (149), Expect = 1e-09
Identities = 62/247 (25%), Positives = 118/247 (47%), Gaps = 13/247 (5%)
Query: 25 EKGEISMEKVKVKRYVSGKRPDYAPMESSDEE--DEEFQFIKKAKEQEAEPEEQE--EDS 80
++ E++ ++ K+ R M + +E+ +EE + +K E + EE+ E+
Sbjct: 2128 KRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEE 2187
Query: 81 SSDPRLRRLQNRISEDVEERLARHR---KIVEPEVVGESDSEVEGDAWRMEREDS-SEEE 136
P L+R + E + + ++ E E E+E +E+++S S EE
Sbjct: 2188 EVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEE 2247
Query: 137 EEEIDDEEIERRRGMMRQRAQERKNEEM-EVMEVEDEGRSGEESESESEYEEYTDSEDEM 195
EEE ++EE ER +R+ +ERK EE E +VE E ++ + E + EE + E+
Sbjct: 2248 EEEREEEE-EREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVF 2306
Query: 196 EPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEEN 255
E + + + + + ++ +E E E+ LE+E R E +K ++E+ +K L
Sbjct: 2307 EEKEEIMSEEETESLSDEEEEEESC---SLEEEVDREKEILKKEKQFKLQEQRRKSLRGR 2363
Query: 256 KRSLAAL 262
+R L+ L
Sbjct: 2364 ERVLSIL 2370
Score = 55.1 bits (131), Expect = 1e-07
Identities = 55/264 (20%), Positives = 121/264 (45%), Gaps = 14/264 (5%)
Query: 61 QFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEV 120
+ IKK + EP + + + +L R + +++++ E ++ + ++ + V E +
Sbjct: 2058 KLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQE-EIKMTKMKRAL---FVKERRLSI 2113
Query: 121 EGDAWRMEREDSSEEEEEEIDDEE-IERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEES 179
E ++ D SE+ E DE+ + R++ + + + N+E ++ E E +
Sbjct: 2114 EQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSE 2173
Query: 180 ESESEYEEYTDSEDEMEPRLKPVFIRKKD---------RVTVQEREAEALKQKELEQEAK 230
+ EE E+E+ P LK + ++K+ + + Q E E+ + E E+
Sbjct: 2174 VILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESL 2233
Query: 231 RMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRD 290
E+++ EEE ++E E + + + ++E EE+ + E K+ K++
Sbjct: 2234 LDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKE 2293
Query: 291 REDREALEKEKAEIERMRNLTEEE 314
++ E EKE+ E+ ++EEE
Sbjct: 2294 KKKEEVQEKEEVFEEKEEIMSEEE 2317
Score = 53.1 bits (126), Expect = 5e-07
Identities = 64/312 (20%), Positives = 141/312 (45%), Gaps = 52/312 (16%)
Query: 52 SSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPE 111
S EE + FQ K K+ +++ + + + + +SE+VEE K+V+ E
Sbjct: 1388 SKKEEKKTFQ--KSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQE 1445
Query: 112 ----VVGESDS------------EVEGD------AWRMEREDSSEEEEEEI--------- 140
++ + S +V G+ AW+ E E +EEE++
Sbjct: 1446 GKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSP 1505
Query: 141 DDEEIERRR------------GMMRQRAQERKNEEMEVMEVEDE-GRSGEESESESEYEE 187
++E ++ + M+ +++E++ ++ E + +E+E R GEE E + E+
Sbjct: 1506 EEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQ 1565
Query: 188 YTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYT---LKIV 244
E+ R+ R + + +ER+ A ++++L QE +++A+E RK +KI
Sbjct: 1566 RHIQEEHKWARIHRKRARAEKKRAQEERKL-AQEEEKLAQEERQLAQEERKLAQAYVKIT 1624
Query: 245 EEETKKELEENKRSLAALDALNTDDE-NDEEEYEAWKVREL-KRIKRDREDREALEKEKA 302
+++ + E K + ++ + E E A K ++L K+ ++ + E L K+
Sbjct: 1625 QDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGG 1684
Query: 303 EIERMRNLTEEE 314
++ ++N+ ++
Sbjct: 1685 KLAEVKNILAQK 1696
Score = 50.8 bits (120), Expect = 2e-06
Identities = 85/349 (24%), Positives = 139/349 (39%), Gaps = 65/349 (18%)
Query: 37 KRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRLQNRISED 96
KR + + + E E+E Q KK K +E + + E SS + ++ ++
Sbjct: 1487 KRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWK-QVWENMLSSKSKEQQYKDEEEVT 1545
Query: 97 VEERLARHRKIVEPEVVGESDSEVEGDAW------RMEREDSSEEEEEEIDDEEIERRRG 150
+EE ++R + E +V E E W R E +EE ++ EE E+
Sbjct: 1546 LEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEE-EKLAQ 1604
Query: 151 MMRQRAQE-RKNEEMEVMEVED-------EGRSGEESESESEYEEYTDSEDEMEPRLKPV 202
RQ AQE RK + V +D EG+ ++ E+ ++ E E E + +
Sbjct: 1605 EERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKK 1664
Query: 203 FIRKKDRVTVQE------------------REAEALKQKE--LEQEAKRMAEERRKY--- 239
+K ++V +E ++ E L Q+E L+ + K +A+E +
Sbjct: 1665 LAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWD 1724
Query: 240 --TLKIVEEETKKE---LEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDR 294
L EEE +E L E K+ LA +EEE AW+ +L +
Sbjct: 1725 MEELSWKEEELNQEEGKLVEEKKKLA-----------EEEEALAWQREKLSEEETKLAQE 1773
Query: 295 EAL---EKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQK 340
E L EKEK + + EEER R + ++ K K QK
Sbjct: 1774 EELLIQEKEKLAQHKEKMPEEEERLGRKR-------EQLIEKKMKLAQK 1815
Score = 43.5 bits (101), Expect = 4e-04
Identities = 53/276 (19%), Positives = 124/276 (44%), Gaps = 29/276 (10%)
Query: 47 YAPMESSDEE--DEEFQFIKK----AKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEER 100
Y + D E E +F +K A+ E +E E+ + +L + +++ + E+
Sbjct: 1620 YVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKL 1679
Query: 101 LARHRKIVEPE-VVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQER 159
+ K+ E + ++ + E+ +RE + + +E+E+ E E M +E
Sbjct: 1680 AKKGGKLAEVKNILAQKVEELP------QREQNLDWQEKELAQELEELEWDMEELSWKEE 1733
Query: 160 KNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVT------VQ 213
+ + E VE++ + EE E+ + E E+ + + + I++K+++ +
Sbjct: 1734 ELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPE 1793
Query: 214 EREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDE 273
E E K+++L ++ ++A++R ++ + +EL +NK L L + +N
Sbjct: 1794 EEERLGRKREQLIEKKMKLAQKRERWI------NSMEELTKNKMILYQKKNLAQEKKNLA 1847
Query: 274 EEYEAWKVRELKRIKRDREDREALEKEKAEIERMRN 309
+E E R+ + ++E L K ++ +++N
Sbjct: 1848 QEKEKLAQRKENLL----YNKERLTHSKKQLVQVKN 1879
Score = 43.5 bits (101), Expect = 4e-04
Identities = 30/140 (21%), Positives = 68/140 (48%), Gaps = 11/140 (7%)
Query: 24 NEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSD 83
+E+ E +++++ + +S + + E EE+E + ++ KE+E E+Q E +
Sbjct: 2227 SEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEE 2286
Query: 84 PRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDE 143
+ ++ + + E+V+E+ E V E E+ + D EEEE +E
Sbjct: 2287 KKKKKKEKK-KEEVQEK----------EEVFEEKEEIMSEEETESLSDEEEEEESCSLEE 2335
Query: 144 EIERRRGMMRQRAQERKNEE 163
E++R + ++++ Q + E+
Sbjct: 2336 EVDREKEILKKEKQFKLQEQ 2355
Score = 40.4 bits (93), Expect = 0.003
Identities = 75/361 (20%), Positives = 158/361 (43%), Gaps = 72/361 (19%)
Query: 22 VRNEKGEISMEKVKV---KRYVSGKRPDYAPMESSDEEDEEFQFIKK---AKEQEAEPEE 75
+ E+G++ EK K+ + ++ +R + E+ ++EE +K A+ +E PEE
Sbjct: 1735 LNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEE 1794
Query: 76 QEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVV--GESDSEVEGDAWRMEREDSS 133
+E +L + ++++ E + ++ + +++ + + E E+E +
Sbjct: 1795 EERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLA 1854
Query: 134 EEEEEEIDDEE-----------IERRRGMMRQ---RAQERKNEEMEVMEVEDEGRSGEES 179
+ +E + ++E ++ + GM + + +E+ +E E + + E + +
Sbjct: 1855 QRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKE----KLA 1910
Query: 180 ESESEYEEYTDS---------EDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAK 230
E+E + + DS +++M+ L+ ++ K R+ + A+ ++K L E K
Sbjct: 1911 ETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAK--EEKALNLEMK 1968
Query: 231 RMAEERR-----KYTLKIVE----------EETKKELEENKRSLAALDALNTDDENDEEE 275
R+AEE+ K TL E + ++EL E K SL L+ D EE
Sbjct: 1969 RLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEE 2028
Query: 276 YEAWKVR-------------ELKRIKRDR---EDREALEKEKAEIER----MRNLTEEER 315
E K + + K K R + RE+L KE A++ + ++ LT +ER
Sbjct: 2029 SEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDER 2088
Query: 316 R 316
+
Sbjct: 2089 K 2089
Score = 34.7 bits (78), Expect = 0.18
Identities = 31/125 (24%), Positives = 63/125 (50%), Gaps = 9/125 (7%)
Query: 193 DEMEPRLKPVFIRKKD--RVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKK 250
D + P KP+FI++ +Q E ++ KE+ + A+++ + L + EET+
Sbjct: 1308 DVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGL--EETQV 1365
Query: 251 ELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNL 310
L++ K+ + L+ N + + E K + K ++ R+A++KE+ + R +
Sbjct: 1366 ILKKGKKVIF-LEPGNVTMGKEISKKEEKKTFQ----KSPKQGRKAVQKERKVGKIKREM 1420
Query: 311 TEEER 315
T+EER
Sbjct: 1421 TKEER 1425
Score = 32.0 bits (71), Expect = 1.1
Identities = 34/156 (21%), Positives = 67/156 (42%), Gaps = 28/156 (17%)
Query: 6 ALMKQPPIQSTAGAVPVRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKK 65
+L+ + Q + + + E E+ +V+ ++ + E E++EE + KK
Sbjct: 2232 SLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKK 2291
Query: 66 AKEQEAEPEEQEEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAW 125
++++ E +E+EE + E+ EE ++ E E SD E
Sbjct: 2292 KEKKKEEVQEKEE--------------VFEEKEEIMS------EEETESLSDEE------ 2325
Query: 126 RMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKN 161
E E+S EEE ++EI ++ + + Q RK+
Sbjct: 2326 --EEEESCSLEEEVDREKEILKKEKQFKLQEQRRKS 2359
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 70.1 bits (170), Expect = 4e-12
Identities = 63/299 (21%), Positives = 139/299 (46%), Gaps = 24/299 (8%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQE-EDS 80
VR ++G++ ++ +V+ R + + + E + + +EQE + EQE +
Sbjct: 54 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE--GQVREQEGQVREQEGQVR 111
Query: 81 SSDPRLRRLQNRISEDVEERLARHRKIVEPE-VVGESDSEVEGDAWRMEREDSSEEEEEE 139
+ ++R + ++ E + + ++ E E V E + +V E+E E+E +
Sbjct: 112 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR------EQEGQVREQEGQ 165
Query: 140 IDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRL 199
+ ++E + R + R QE + E E E EG+ GE+ E E EE ++E
Sbjct: 166 VREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQ 225
Query: 200 KPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSL 259
+ ++++++ QE + + + E++ ++ E+ RK +EE +E EE R
Sbjct: 226 EEQMRKQEEQMGEQEEQVQ-----KQEEQVQKQEEQMRK------QEEQMREQEEQMREQ 274
Query: 260 AALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAE 318
L ++ ++EE + +++ +++ + RE E+ + + E+MR E+ + E
Sbjct: 275 EE-QMLKQKEQTEQEEQTGEQEEQMR--EQEEQMREQEEQMREQEEQMREQEEQMGKQE 330
Score = 69.3 bits (168), Expect = 6e-12
Identities = 62/308 (20%), Positives = 153/308 (49%), Gaps = 35/308 (11%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQE-EDS 80
VR ++G++ ++ +V+ R + + + E + + +EQE + EQE +
Sbjct: 103 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE--GQVREQEGQVREQEGQVR 160
Query: 81 SSDPRLRRLQNRISEDVEERLARHRKIVEPE-VVGESDSEVEGDAWRM-EREDSSEEEEE 138
+ ++R + ++ E + + ++ E E +GE + ++ +M E+E+ +++EE
Sbjct: 161 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEE 220
Query: 139 EI--DDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYTDSEDEME 196
++ +E++ ++ M ++ ++ + +E +V + E++ R EE E E E+ + E++M
Sbjct: 221 QMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQE-EQMREQEEQM- 278
Query: 197 PRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEENK 256
+++K++ +E+ E +Q ++E R EE+ + +EE +E EE
Sbjct: 279 -------LKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMR-----EQEEQMREQEEQM 326
Query: 257 RSLAALDALNTDDENDEEEYEAWKVRE--LKRIKRDREDREALEKEKAEI----ERMRNL 310
+++ E++ + W+ +E K+ ++ E E ++K++ ++ E+MR
Sbjct: 327 G--------KQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQ 378
Query: 311 TEEERRAE 318
E+ R+ E
Sbjct: 379 EEQMRKQE 386
Score = 68.9 bits (167), Expect = 8e-12
Identities = 63/308 (20%), Positives = 140/308 (45%), Gaps = 29/308 (9%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQEEDSS 81
VR ++G++ ++ +V+ R + + + E + + +EQE + EQE
Sbjct: 138 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE--GQVREQEGQVREQEGQMG 195
Query: 82 SDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRM-EREDSSEEEEEEI 140
Q + EE++ + + E +GE + ++ +M E+E+ +++EE++
Sbjct: 196 EQEGQMGEQEEQMGEQEEQMQK-----QEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQV 250
Query: 141 DDEEIERRRGMMRQRAQERKNEEMEVM------EVEDEGRSGEESESESEYEEYTDSEDE 194
+E + R+ + R QE + E E + E E ++GE+ E E EE ++E
Sbjct: 251 QKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEE 310
Query: 195 MEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKKELEE 254
++ ++E+E + KQ+E E K E+++ K E+ ++E +
Sbjct: 311 Q---------MREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQM 361
Query: 255 NKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEE- 313
K+ + + +E ++ E + +E + K++ + E E+ + E+MR E+
Sbjct: 362 QKQE----EQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQM 417
Query: 314 -ERRAELR 320
E++ ++R
Sbjct: 418 GEQKEQMR 425
Score = 61.2 bits (147), Expect = 2e-09
Identities = 51/247 (20%), Positives = 116/247 (46%), Gaps = 22/247 (8%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEE-DEEFQFIKKAKEQEAEPEEQ---- 76
VR ++G++ ++ ++ M+ +E+ E+ + ++K +EQ E EEQ
Sbjct: 187 VREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQ 246
Query: 77 --------EEDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRM- 127
E+ + ++R + ++ E E+ L + + + E GE + ++ +M
Sbjct: 247 EEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMR 306
Query: 128 EREDSSEEEEEEIDDEEIERRRGMMRQRAQERKN---EEMEVMEVEDEGRSGEESESESE 184
E+E+ E+EE++ E E + G ++ E+K E+ E M ++E +E + + +
Sbjct: 307 EQEEQMREQEEQM--REQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQ 364
Query: 185 YEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIV 244
E+ E++M + + + +K ++++E + +QKE E K E+ + +
Sbjct: 365 EEQVRKQEEQMRKQEEQM---RKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQK 421
Query: 245 EEETKKE 251
E+ K+E
Sbjct: 422 EQMRKQE 428
Score = 47.8 bits (112), Expect = 2e-05
Identities = 34/196 (17%), Positives = 85/196 (43%), Gaps = 25/196 (12%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEE----DEEFQFIKKAKEQEAEPEEQE 77
V+ ++ ++ ++ ++++ R M +E+ E+ + ++ EQE + EQE
Sbjct: 243 VQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQE 302
Query: 78 EDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEE 137
E R Q + EE++ + + + + E E + W+ E + +EE+
Sbjct: 303 EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQK--EQMWEQKEQMWKQEEQMGEQEEQ 360
Query: 138 EEIDDEEIERRRGMMRQRAQERKNEEMEVMEVED-------------------EGRSGEE 178
+ +E++ ++ MR++ ++ + +E ++ + E+ E + GE+
Sbjct: 361 MQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQ 420
Query: 179 SESESEYEEYTDSEDE 194
E + EE+ + E
Sbjct: 421 KEQMRKQEEHMGEQKE 436
Score = 46.6 bits (109), Expect = 4e-05
Identities = 35/215 (16%), Positives = 98/215 (45%), Gaps = 30/215 (13%)
Query: 22 VRNEKGEISMEKVKVKRYVSGKRPDYAPMESSDEEDEEFQFIKKAKEQEAEPEEQ----- 76
+R ++ ++ ++ +V++ + M +E+ +++ +EQ E EEQ
Sbjct: 229 MRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQ------MREQEEQMREQEEQMLKQK 282
Query: 77 ------EEDSSSDPRLRRLQNRISEDVEERLARHRKIVE-PEVVGESDS----------E 119
E+ + ++R + ++ E E+ + ++ E E +G+ + E
Sbjct: 283 EQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWE 342
Query: 120 VEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEES 179
+ W+ E + +EE+ + +E++ ++ MR++ ++ + +E ++ + E++ GE+
Sbjct: 343 QKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQ--MGEQK 400
Query: 180 ESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQE 214
E E +E ++E K ++++ + Q+
Sbjct: 401 EQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQK 435
>gi|48255881 troponin T type 2, cardiac isoform 3 [Homo sapiens]
Length = 285
Score = 69.7 bits (169), Expect = 5e-12
Identities = 72/294 (24%), Positives = 138/294 (46%), Gaps = 32/294 (10%)
Query: 50 MESSDEEDEEFQFIKKAKEQEAEPEEQEE--DSSSDPRLRRLQNRISEDVEERLARHRKI 107
M +E EE++ + +++EA EEQEE + ++ + R ED EE A+
Sbjct: 1 MSDIEEVVEEYE---EEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAK---- 53
Query: 108 VEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRR---------GMMRQRAQE 158
E E +S+ + ++ + E +D ++I R+R ++ +
Sbjct: 54 -EAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFEN 112
Query: 159 RKNEEMEVMEVED--EGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQERE 216
RK EE E++ ++D E R E +E + E E E + RL R+++ ++ E
Sbjct: 113 RKKEEEELVSLKDRIERRRAERAEQQRIRNE---REKERQNRLAEERARREEEENRRKAE 169
Query: 217 AEALKQKELEQE---AKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDE 273
EA K+K L + + RK + E E KK++ +R + A+D LN +D+ E
Sbjct: 170 DEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLN-EDQLRE 228
Query: 274 EEYEAWKVRELKRIKRDRED-REALEKEKAEIERMRN-LTEEERRAELRANGKV 325
+ E W + + ++ ++ D +E +++K EI +RN + + ++ ++ R KV
Sbjct: 229 KAKELW--QSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKV 280
Score = 43.5 bits (101), Expect = 4e-04
Identities = 60/238 (25%), Positives = 88/238 (36%), Gaps = 53/238 (22%)
Query: 130 EDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRSGEESESESEYEEYT 189
E+ EE EEE +E QE EE E E E EE E E E +E
Sbjct: 5 EEVVEEYEEEEQEEAAVEE--------QEEAAEEDAEAEAETEETRAEEDEEEEEAKEAE 56
Query: 190 DSEDE--------MEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTL 241
D E P L P I +RV + + + +K +E++ +
Sbjct: 57 DGPMEESKPKPRSFMPNLVPPKIPDGERV-----DFDDIHRKRMEKDLNELQ-------- 103
Query: 242 KIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVR-ELKRIKRDREDREALEKE 300
A ++A + + +EEE + K R E +R +R + R E+E
Sbjct: 104 ------------------ALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNERE 145
Query: 301 KAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKR 358
K ER L EE R E N + ++A K K L H G + + + KR
Sbjct: 146 K---ERQNRLAEERARREEEENRRKAEDEA--RKKKALSNMMHFGGYIQKTERKSGKR 198
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 68.9 bits (167), Expect = 8e-12
Identities = 56/281 (19%), Positives = 132/281 (46%), Gaps = 31/281 (11%)
Query: 58 EEFQFIKKAKEQEAEPEEQEED--SSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGE 115
E+ Q ++KAK + E E +E + + + R+ Q + EE L R +
Sbjct: 718 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQ---------- 767
Query: 116 SDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNEEMEVMEVEDEGRS 175
E + R E E+ + ++EE + E+ + RQR +E + ++ E + +E R
Sbjct: 768 -----EEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRR 822
Query: 176 GEES---------ESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELE 226
EE + E E ++ E+E + RL+ +R ++ E E K+KELE
Sbjct: 823 EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE 882
Query: 227 ----QEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEAWKVR 282
+E R +++++ ++ +++ +++L + K ++ ++ + + +
Sbjct: 883 VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQ-ATLSLA 941
Query: 283 ELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANG 323
E+++++ +RE + E+ + + E M+ L +++++ + + +G
Sbjct: 942 EIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSG 982
Score = 60.1 bits (144), Expect = 4e-09
Identities = 65/277 (23%), Positives = 115/277 (41%), Gaps = 59/277 (21%)
Query: 78 EDSSSDPRLRRLQNRISEDVEERLARHRKIVEPEVVGESDSEVEGDAWRMERED----SS 133
+ ++ P L +LQ ++ + +L + R+ E E + + R ++E+
Sbjct: 709 DTTTPGPALEQLQ-QLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQ 767
Query: 134 EEEEEEIDDEEIERRR---GMMRQRAQE----RKNEEMEVMEVEDEGRSGEESESESEYE 186
EEE + ++EE+ RR+ + RQR QE R+ EE E + E+ R EE E E
Sbjct: 768 EEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE- 826
Query: 187 EYTDSEDEMEPRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEE 246
R+K ++++E EA K E+EA+R EE R L++ EE
Sbjct: 827 ------------------RRKQEELLRKQEEEAAKWAREEEEAQRRLEENR---LRMEEE 865
Query: 247 ETKKELEENKRSLAALDALNTDDENDEEEYEAWKVRELKRIKRDRE-------------- 292
+ EE +R L+ + + + + +R L++ ++ ++
Sbjct: 866 AARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQ 925
Query: 293 -----------DREALEKEKAEIERMRNLTEEERRAE 318
E +K E ER R L EE+RR +
Sbjct: 926 QSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQ 962
Score = 49.7 bits (117), Expect = 5e-06
Identities = 58/332 (17%), Positives = 135/332 (40%), Gaps = 34/332 (10%)
Query: 2 SVPSALMKQPPIQSTAGAVPVRNEKGEISM----EKVKVKRYVSGKRPDYAPMESSDEED 57
+ P ++Q A A + E+ E M E+ + KR +R + EE+
Sbjct: 711 TTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEE 770
Query: 58 E---EFQFIKKAKEQEA------------EPEEQEEDSSSDPRLRRLQNRISEDVEERLA 102
E + + + K++EA E+EE + LRRL+ R E+ E R
Sbjct: 771 RKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERR-- 828
Query: 103 RHRKIVEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRRGMMRQRAQERKNE 162
+ +++ + E E W E E++ EE + +E +R +ERK +
Sbjct: 829 KQEELLRKQ-------EEEAAKWAREEEEAQRRLEE--NRLRMEEEAARLRHEEEERKRK 879
Query: 163 EMEVMEVEDEGRSGEESESESEYEEYTDSEDEMEPRLKP---VFIRKKDRVTVQEREAEA 219
E+EV ++ R ++ + + + ++ P + ++ + Q + +
Sbjct: 880 ELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLS 939
Query: 220 LKQ-KELEQEAKRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDENDEEEYEA 278
L + ++LE+E +R E ++ + + + +++ ++ ++ L+ ++ + E
Sbjct: 940 LAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEI 999
Query: 279 WKVRELKRIKRDREDREALEKEKAEIERMRNL 310
+ + K+ ++ ++ + +A NL
Sbjct: 1000 QQEEARQMQKQQQQQQQHQQPNRARNNTHSNL 1031
Score = 39.3 bits (90), Expect = 0.007
Identities = 47/209 (22%), Positives = 81/209 (38%), Gaps = 25/209 (11%)
Query: 213 QEREAEALKQKELEQEAKRMAEERRKYT---LKIVEEETKKELEENKRSLAALDALNTDD 269
QER ++ K E+E KR E RR+ + EEE K+ EE +AL
Sbjct: 733 QERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQR 792
Query: 270 END-------EEEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRAN 322
E + EEE + L+R++ R + E K++ + + + R E A
Sbjct: 793 EQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQ 852
Query: 323 GKVITNKAVKGKYKFLQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTIL-PKVMQVK 381
++ N+ + A E+EE +++ LE K ++ + Q +
Sbjct: 853 RRLEENRL---------RMEEEAARLRHEEEERKRKE-----LEVQRQKELMRQRQQQQE 898
Query: 382 NFGRSGRTKYTHLVDQDTTSFDSAWGQES 410
R + + + Q S WGQ+S
Sbjct: 899 ALRRLQQQQQQQQLAQMKLPSSSTWGQQS 927
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.125 0.330
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,030,260
Number of Sequences: 37866
Number of extensions: 904655
Number of successful extensions: 27446
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 689
Number of HSP's successfully gapped in prelim test: 1379
Number of HSP's that attempted gapping in prelim test: 6759
Number of HSP's gapped (non-prelim): 8903
length of query: 439
length of database: 18,247,518
effective HSP length: 105
effective length of query: 334
effective length of database: 14,271,588
effective search space: 4766710392
effective search space used: 4766710392
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.