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Search of human proteins with 50726952
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
sapiens]
(318 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap... 644 0.0
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 333 1e-91
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens] 314 8e-86
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 299 2e-81
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo... 274 7e-74
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom... 274 7e-74
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom... 274 7e-74
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo... 274 7e-74
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 170 1e-42
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 170 1e-42
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 170 1e-42
gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo sapi... 155 3e-38
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens] 149 2e-36
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 86 4e-17
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 82 8e-16
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi... 75 1e-13
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 72 5e-13
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 70 3e-12
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 68 1e-11
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 66 5e-11
gi|186928839 retinol dehydrogenase 12 [Homo sapiens] 66 5e-11
gi|40254992 carbonic reductase 4 [Homo sapiens] 66 5e-11
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 65 8e-11
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 65 8e-11
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [... 64 2e-10
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens] 63 4e-10
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 63 4e-10
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 62 7e-10
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ... 60 3e-09
gi|25282469 retinol dehydrogenase 10 [Homo sapiens] 60 3e-09
>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
sapiens]
Length = 318
Score = 644 bits (1660), Expect = 0.0
Identities = 318/318 (100%), Positives = 318/318 (100%)
Query: 1 MWLPLLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCL 60
MWLPLLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCL
Sbjct: 1 MWLPLLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCL 60
Query: 61 TPSGAEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGP 120
TPSGAEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGP
Sbjct: 61 TPSGAEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGP 120
Query: 121 TPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKF 180
TPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKF
Sbjct: 121 TPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKF 180
Query: 181 GLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNLESLEKTLQACWARLPPATQAHYGGA 240
GLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNLESLEKTLQACWARLPPATQAHYGGA
Sbjct: 181 GLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNLESLEKTLQACWARLPPATQAHYGGA 240
Query: 241 FLTKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPAS 300
FLTKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPAS
Sbjct: 241 FLTKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPAS 300
Query: 301 LVDAVLTWVLPKPAQAVY 318
LVDAVLTWVLPKPAQAVY
Sbjct: 301 LVDAVLTWVLPKPAQAVY 318
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 333 bits (854), Expect = 1e-91
Identities = 167/318 (52%), Positives = 228/318 (71%), Gaps = 2/318 (0%)
Query: 1 MWLPLLLGALLWAVLWLLRDRQSLP-ASNAFVFITGCDSGFGRLLALQLDQRGFRVLASC 59
MWL L + L+ +L R+RQ L + +VFITGCDSGFG+LLA QLD RG RVLA+C
Sbjct: 1 MWLYLAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAAC 60
Query: 60 LTPSGAEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIG 119
LT GAE L+ S RL T LD+T +SV AA+WV+ V++ GL+GLVNNAG++
Sbjct: 61 LTEKGAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTA 120
Query: 120 PTPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSK 179
P LT+ DF +L+VN +G I VTL+LLPL+++ARGRV+N++SV+GR++ GGGYC+SK
Sbjct: 121 PNELLTKQDFVTILDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISK 180
Query: 180 FGLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNLESLEKTLQACWARLPPATQAHYGG 239
+G+EAFSDSLRR++++FG++V+++EPG+F+T VT+ E K+ W R P + YG
Sbjct: 181 YGVEAFSDSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGE 240
Query: 240 AFLTKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPA 299
F+ Y K ++ M C DL+ V+ C+EHAL A HPRTRYS GWDAKLL+LP SY+P
Sbjct: 241 KFVADYKKSAEQ-MEQKCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPT 299
Query: 300 SLVDAVLTWVLPKPAQAV 317
LVDA++ WV P PA+A+
Sbjct: 300 FLVDAIMYWVSPSPAKAL 317
>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
Length = 317
Score = 314 bits (804), Expect = 8e-86
Identities = 165/320 (51%), Positives = 221/320 (69%), Gaps = 6/320 (1%)
Query: 1 MWLPLLLGALLWAVLWLLRDRQSLP-ASNAFVFITGCDSGFGRLLALQLDQRGFRVLASC 59
MWL L L+ +L R+RQ + + +VFITGCDSGFG LLA QLD RG RVLA+C
Sbjct: 1 MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC 60
Query: 60 LTPSGAEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIG 119
LT GAE L+ S RL T LD+T +S+ A +WV+ HV + GL+GLVNNAG+ I
Sbjct: 61 LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT 120
Query: 120 PTPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSK 179
WL +D +L VN +G I VTL++LPL+++ARGR++N++S+LGR+A GGYCVSK
Sbjct: 121 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK 180
Query: 180 FGLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNL-ESLEKTLQACWARLPPATQAHYG 238
+G+EAFSD LRR++ HFG+++SIVEPG+FRT +TN+ +SLE+ Q+ W P + YG
Sbjct: 181 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQS-WKEAPKHIKETYG 239
Query: 239 GAFL-TKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYL 297
+ Y M++ ++N C +L V+ C+EHALT+ HPRTRYS GWDAK ++P SYL
Sbjct: 240 QQYFDALYNIMKEGLLN--CSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYL 297
Query: 298 PASLVDAVLTWVLPKPAQAV 317
P SL D +LT PKPAQAV
Sbjct: 298 PTSLADYILTRSWPKPAQAV 317
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 299 bits (766), Expect = 2e-81
Identities = 149/291 (51%), Positives = 204/291 (70%), Gaps = 1/291 (0%)
Query: 27 SNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRVASSRLHTTLLDITDP 86
S +VFITGCDSGFG LLA QL RG +VLA+C T G++ LQR S RL TTLLD+T
Sbjct: 24 SEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTTLLDVTKS 83
Query: 87 QSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPIGVTLA 146
+S++ AA+WV V E GL+ LVNNAGV GP WLT+DDF +V+NVN +G I VTL
Sbjct: 84 ESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVGLIEVTLH 143
Query: 147 LLPLLQQARGRVINITSVLGRLAANGGGYCVSKFGLEAFSDSLRRDVAHFGIRVSIVEPG 206
+LP++++ARGRV+N++S GR+A GGGYCVSKFG+EAFSDS+RR++ +FG++V I+EPG
Sbjct: 144 MLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVEAFSDSIRRELYYFGVKVCIIEPG 203
Query: 207 FFRTPVTNLESLEKTLQACWARLPPATQAHYGGAFLTKYLKMQQRIMNLICDPDLTKVSR 266
+RT + E+LE ++ W RLP T+ YG + Y + IM + +P + V
Sbjct: 204 NYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNIMQ-VAEPRVRDVIN 262
Query: 267 CLEHALTARHPRTRYSPGWDAKLLWLPASYLPASLVDAVLTWVLPKPAQAV 317
+EHA+ +R PR RY+PG DAKLL++P + LP + D +L+ LP+PA +V
Sbjct: 263 SMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDFILSRYLPRPADSV 313
>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 274 bits (701), Expect = 7e-74
Identities = 137/299 (45%), Positives = 205/299 (68%), Gaps = 4/299 (1%)
Query: 10 LLWAVLWLLRDRQSLP-ASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDL 68
+L LW + + + ++ ++FITGCDSGFG L A D++GF V+A+CLT SG+ L
Sbjct: 10 ILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTAL 69
Query: 69 QRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDD 128
+ S RL T LLD+TDP++V++ A+WV+ V E GL+GL+NNAGV G++ PT WLT +D
Sbjct: 70 KAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLED 129
Query: 129 FQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKFGLEAFSDS 188
++ + VN G I VTL +LPL+++A+GRVIN++SV GRLA GGGY SK+ +E F+DS
Sbjct: 130 YREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDS 189
Query: 189 LRRDVAHFGIRVSIVEPGFFRTPVTN-LESLEKTLQACWARLPPATQAHYGGAFLTKYLK 247
LRRD+ FG+ VS +EPG F+T + + ++ +EK L A W +L P + YG ++ K L
Sbjct: 190 LRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKL-AIWEQLSPDIKQQYGEGYIEKSLD 248
Query: 248 MQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPASLVDAVL 306
+ + + + DL+ V C++HALT+ P+T Y+ G DAK+ W+P S++PA+L D +L
Sbjct: 249 KLKGNKSYV-NMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 274 bits (701), Expect = 7e-74
Identities = 137/299 (45%), Positives = 205/299 (68%), Gaps = 4/299 (1%)
Query: 10 LLWAVLWLLRDRQSLP-ASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDL 68
+L LW + + + ++ ++FITGCDSGFG L A D++GF V+A+CLT SG+ L
Sbjct: 10 ILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTAL 69
Query: 69 QRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDD 128
+ S RL T LLD+TDP++V++ A+WV+ V E GL+GL+NNAGV G++ PT WLT +D
Sbjct: 70 KAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLED 129
Query: 129 FQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKFGLEAFSDS 188
++ + VN G I VTL +LPL+++A+GRVIN++SV GRLA GGGY SK+ +E F+DS
Sbjct: 130 YREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDS 189
Query: 189 LRRDVAHFGIRVSIVEPGFFRTPVTN-LESLEKTLQACWARLPPATQAHYGGAFLTKYLK 247
LRRD+ FG+ VS +EPG F+T + + ++ +EK L A W +L P + YG ++ K L
Sbjct: 190 LRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKL-AIWEQLSPDIKQQYGEGYIEKSLD 248
Query: 248 MQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPASLVDAVL 306
+ + + + DL+ V C++HALT+ P+T Y+ G DAK+ W+P S++PA+L D +L
Sbjct: 249 KLKGNKSYV-NMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 274 bits (701), Expect = 7e-74
Identities = 137/299 (45%), Positives = 205/299 (68%), Gaps = 4/299 (1%)
Query: 10 LLWAVLWLLRDRQSLP-ASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDL 68
+L LW + + + ++ ++FITGCDSGFG L A D++GF V+A+CLT SG+ L
Sbjct: 10 ILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTAL 69
Query: 69 QRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDD 128
+ S RL T LLD+TDP++V++ A+WV+ V E GL+GL+NNAGV G++ PT WLT +D
Sbjct: 70 KAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLED 129
Query: 129 FQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKFGLEAFSDS 188
++ + VN G I VTL +LPL+++A+GRVIN++SV GRLA GGGY SK+ +E F+DS
Sbjct: 130 YREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDS 189
Query: 189 LRRDVAHFGIRVSIVEPGFFRTPVTN-LESLEKTLQACWARLPPATQAHYGGAFLTKYLK 247
LRRD+ FG+ VS +EPG F+T + + ++ +EK L A W +L P + YG ++ K L
Sbjct: 190 LRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKL-AIWEQLSPDIKQQYGEGYIEKSLD 248
Query: 248 MQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPASLVDAVL 306
+ + + + DL+ V C++HALT+ P+T Y+ G DAK+ W+P S++PA+L D +L
Sbjct: 249 KLKGNKSYV-NMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 274 bits (701), Expect = 7e-74
Identities = 137/299 (45%), Positives = 205/299 (68%), Gaps = 4/299 (1%)
Query: 10 LLWAVLWLLRDRQSLP-ASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDL 68
+L LW + + + ++ ++FITGCDSGFG L A D++GF V+A+CLT SG+ L
Sbjct: 10 ILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTAL 69
Query: 69 QRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDD 128
+ S RL T LLD+TDP++V++ A+WV+ V E GL+GL+NNAGV G++ PT WLT +D
Sbjct: 70 KAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLED 129
Query: 129 FQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKFGLEAFSDS 188
++ + VN G I VTL +LPL+++A+GRVIN++SV GRLA GGGY SK+ +E F+DS
Sbjct: 130 YREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDS 189
Query: 189 LRRDVAHFGIRVSIVEPGFFRTPVTN-LESLEKTLQACWARLPPATQAHYGGAFLTKYLK 247
LRRD+ FG+ VS +EPG F+T + + ++ +EK L A W +L P + YG ++ K L
Sbjct: 190 LRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKL-AIWEQLSPDIKQQYGEGYIEKSLD 248
Query: 248 MQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPASLVDAVL 306
+ + + + DL+ V C++HALT+ P+T Y+ G DAK+ W+P S++PA+L D +L
Sbjct: 249 KLKGNKSYV-NMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLL 306
>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 170 bits (431), Expect = 1e-42
Identities = 102/271 (37%), Positives = 153/271 (56%), Gaps = 17/271 (6%)
Query: 25 PASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPS----GAEDLQRVASSRLHTTL 80
P + V +TGCDSGFG LA L +GF V A CL G ++L + S RL T
Sbjct: 52 PVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQ 111
Query: 81 LDITDPQSVQQAAKWVEMHVK--EAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTM 138
L++ + V++ + V +K E G++GLVNNAG++ G + + + +++V VN
Sbjct: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIS-TFGEVEFTSLETYKQVAEVNLW 170
Query: 139 GPIGVTLALLPLLQQARGRVINITSVLGRLAANGGG-YCVSKFGLEAFSDSLRRDVAHFG 197
G + +T + LPL+++A+GRV+NI+S+LGR+A YC++KFG+EAFSD LR ++ G
Sbjct: 171 GTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
Query: 198 IRVSIVEPGFF--RTPVTNLESLEKTLQACWARLPPATQAHYGGAFLTKYLKMQQRIMNL 255
++VS+VEPG F T + + ES++ + W LP + YG KY + M
Sbjct: 231 VKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYG----KKYFDEKIAKMET 286
Query: 256 ICDPDLTKVSRCLE---HALTARHPRTRYSP 283
C T S ++ HALTA P TRY P
Sbjct: 287 YCSSGSTDTSPVIDAVTHALTATTPYTRYHP 317
>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 170 bits (431), Expect = 1e-42
Identities = 102/271 (37%), Positives = 153/271 (56%), Gaps = 17/271 (6%)
Query: 25 PASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPS----GAEDLQRVASSRLHTTL 80
P + V +TGCDSGFG LA L +GF V A CL G ++L + S RL T
Sbjct: 52 PVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQ 111
Query: 81 LDITDPQSVQQAAKWVEMHVK--EAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTM 138
L++ + V++ + V +K E G++GLVNNAG++ G + + + +++V VN
Sbjct: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIS-TFGEVEFTSLETYKQVAEVNLW 170
Query: 139 GPIGVTLALLPLLQQARGRVINITSVLGRLAANGGG-YCVSKFGLEAFSDSLRRDVAHFG 197
G + +T + LPL+++A+GRV+NI+S+LGR+A YC++KFG+EAFSD LR ++ G
Sbjct: 171 GTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
Query: 198 IRVSIVEPGFF--RTPVTNLESLEKTLQACWARLPPATQAHYGGAFLTKYLKMQQRIMNL 255
++VS+VEPG F T + + ES++ + W LP + YG KY + M
Sbjct: 231 VKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYG----KKYFDEKIAKMET 286
Query: 256 ICDPDLTKVSRCLE---HALTARHPRTRYSP 283
C T S ++ HALTA P TRY P
Sbjct: 287 YCSSGSTDTSPVIDAVTHALTATTPYTRYHP 317
>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 170 bits (431), Expect = 1e-42
Identities = 102/271 (37%), Positives = 153/271 (56%), Gaps = 17/271 (6%)
Query: 25 PASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPS----GAEDLQRVASSRLHTTL 80
P + V +TGCDSGFG LA L +GF V A CL G ++L + S RL T
Sbjct: 52 PVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQ 111
Query: 81 LDITDPQSVQQAAKWVEMHVK--EAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTM 138
L++ + V++ + V +K E G++GLVNNAG++ G + + + +++V VN
Sbjct: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIS-TFGEVEFTSLETYKQVAEVNLW 170
Query: 139 GPIGVTLALLPLLQQARGRVINITSVLGRLAANGGG-YCVSKFGLEAFSDSLRRDVAHFG 197
G + +T + LPL+++A+GRV+NI+S+LGR+A YC++KFG+EAFSD LR ++ G
Sbjct: 171 GTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
Query: 198 IRVSIVEPGFF--RTPVTNLESLEKTLQACWARLPPATQAHYGGAFLTKYLKMQQRIMNL 255
++VS+VEPG F T + + ES++ + W LP + YG KY + M
Sbjct: 231 VKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYG----KKYFDEKIAKMET 286
Query: 256 ICDPDLTKVSRCLE---HALTARHPRTRYSP 283
C T S ++ HALTA P TRY P
Sbjct: 287 YCSSGSTDTSPVIDAVTHALTATTPYTRYHP 317
>gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
sapiens]
Length = 405
Score = 155 bits (393), Expect = 3e-38
Identities = 104/300 (34%), Positives = 150/300 (50%), Gaps = 5/300 (1%)
Query: 6 LLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCL--TPS 63
+L A W L L Q LP + V ITGCDSGFG+ A +LD GF VLA+ L
Sbjct: 60 VLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSP 119
Query: 64 GAEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPW 123
GA +L+ S RL +D+T P + + ++ + H GL+GLVNNAG ++
Sbjct: 120 GAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAEL 179
Query: 124 LTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANG-GGYCVSKFGL 182
F+ + VN G + +T LLPLL+ +RGR++ + S G + G Y SK +
Sbjct: 180 SPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAV 239
Query: 183 EAFSDSLRRDVAHFGIRVSIVEPGFFRT-PVTNLESLEKTLQACWARLPPATQAHYGGAF 241
D+ ++ +G++VSI++PG F+T V N+ EK Q A LP YG +
Sbjct: 240 ALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDY 299
Query: 242 LTKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPASL 301
+ ++L Q + DLT V + AL A PR RY PG L++ YLP L
Sbjct: 300 I-EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGL 358
>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
Length = 387
Score = 149 bits (377), Expect = 2e-36
Identities = 100/314 (31%), Positives = 160/314 (50%), Gaps = 21/314 (6%)
Query: 2 WLPLLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLT 61
W +L + + L ++ LP V +TG D G G L LD+ GF V A L
Sbjct: 56 WGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLN 115
Query: 62 PSG--AEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIG 119
+G AE+L+R S RL +DIT P ++ A V +++ GL+ ++NNAGV G
Sbjct: 116 ENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPT 175
Query: 120 PTPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLG-----RLAANGGG 174
L D+++ + VN G + VT LPLL++++GR++N++S+ G RLA+ G
Sbjct: 176 DGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGS- 234
Query: 175 YCVSKFGLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNL-ESLEKTLQACWARLPPAT 233
SK + FS +R +++ +GI+V+ ++PG F T + + EK + LP
Sbjct: 235 ---SKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEV 291
Query: 234 QAHYGGAFLTKYLKMQQR----IMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKL 289
Q YG ++ + QR ++N + D + V R ++HA+ A+ P Y+PG A L
Sbjct: 292 QEDYGQDYI-----LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYL 346
Query: 290 LWLPASYLPASLVD 303
A YLP + D
Sbjct: 347 WICLAHYLPIGIYD 360
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 85.9 bits (211), Expect = 4e-17
Identities = 65/192 (33%), Positives = 99/192 (51%), Gaps = 15/192 (7%)
Query: 24 LPASNAFVFITGCDSGFGRLLALQL---DQRGFRVLASCLTPSGAEDLQRVASSRLHTTL 80
+ A+ V I+GC SG G LA+QL ++ ++V+A+ E L+ A L TL
Sbjct: 1 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTL 60
Query: 81 ----LDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVN 136
LD+ +SV Q ++ V LVNNAG+ G++GP L+ Q V + N
Sbjct: 61 TVAQLDVCSDESVAQCLSCIQGEVDV-----LVNNAGM-GLVGPLEGLSLAAMQNVFDTN 114
Query: 137 TMGPIGVTLALLPLLQQAR-GRVINITSVLGRLAANGGG-YCVSKFGLEAFSDSLRRDVA 194
G + + A+LP +++ R G ++ I+SV+G Y SKF LE F +SL +
Sbjct: 115 FFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLL 174
Query: 195 HFGIRVSIVEPG 206
F I +S+VEPG
Sbjct: 175 QFNIFISLVEPG 186
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 81.6 bits (200), Expect = 8e-16
Identities = 68/225 (30%), Positives = 111/225 (49%), Gaps = 24/225 (10%)
Query: 3 LPLLLGAL----LWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLAS 58
LPLL G L L+ +L +R + L NA V ITG SG G+ A G +++
Sbjct: 25 LPLLFGCLGVFGLFRLLQWVRGKAYL--RNAVVVITGATSGLGKECAKVFYAAGAKLVLC 82
Query: 59 CLTPSGAEDLQR---------VASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLV 109
E+L R V + + + D+TD ++ AA + + LV
Sbjct: 83 GRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDI--LV 140
Query: 110 NNAGVA--GIIGPTPWLTRDDFQRVLNVNTMGPIGVTLALLP-LLQQARGRVINITSVLG 166
NNAG++ G I T T D +RV+ N GP+ +T ALLP ++++ +G ++ I+S+ G
Sbjct: 141 NNAGISYRGTIMDT---TVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQG 197
Query: 167 RLAAN-GGGYCVSKFGLEAFSDSLRRDVAHFGIRVSIVEPGFFRT 210
+++ Y SK +AF D LR ++ + I V+++ PG+ T
Sbjct: 198 KMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHT 242
>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
Length = 328
Score = 74.7 bits (182), Expect = 1e-13
Identities = 64/187 (34%), Positives = 92/187 (49%), Gaps = 16/187 (8%)
Query: 31 VFITGCDSGFGRLLALQL---DQRGFRVLASCLTPSGAEDLQRVASS------RLHTTLL 81
V ITGC SG G LA++L + F+V A+ L A + L T L
Sbjct: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65
Query: 82 DITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPI 141
D+ D +SV A + V E + LV NAG+ G++GP L D VL+VN +G +
Sbjct: 66 DVRDSKSVAAARE----RVTEGRVDVLVCNAGL-GLLGPLEALGEDAVASVLDVNVVGTV 120
Query: 142 GVTLALLP-LLQQARGRVINITSVLGRLAANGGG-YCVSKFGLEAFSDSLRRDVAHFGIR 199
+ A LP + ++ GRV+ SV G + YC SKF LE +SL + FG+
Sbjct: 121 RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 180
Query: 200 VSIVEPG 206
+S++E G
Sbjct: 181 LSLIECG 187
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 72.4 bits (176), Expect = 5e-13
Identities = 63/210 (30%), Positives = 109/210 (51%), Gaps = 21/210 (10%)
Query: 10 LLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQ 69
LLWA W R R ++ V++TG SG G LA QL + G ++ S E ++
Sbjct: 34 LLWAE-WQGR-RPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVK 91
Query: 70 R-------VASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFG-LVNNAGVA--GIIG 119
R + + LD+TD S + A K V ++E G LVNN G++ +
Sbjct: 92 RRCLENGNLKEKDILVLPLDLTDTGSHEAATKAV---LQEFGRIDILVNNGGMSQRSLCM 148
Query: 120 PTPWLTRDDFQRVLNVNTMGPIGVTLALLP-LLQQARGRVINITSVLGRLAAN-GGGYCV 177
T + D +++++ +N +G + +T +LP ++++ +G+++ + S+LG ++ GYC
Sbjct: 149 DT---SLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCA 205
Query: 178 SKFGLEAFSDSLRRDVAHF-GIRVSIVEPG 206
SK L F + LR ++A + GI VS + PG
Sbjct: 206 SKHALRGFFNGLRTELATYPGIIVSNICPG 235
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 69.7 bits (169), Expect = 3e-12
Identities = 62/215 (28%), Positives = 103/215 (47%), Gaps = 16/215 (7%)
Query: 7 LGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAE 66
L +LL A+++ L + + V ITG SG GRLLALQ + G ++ + G E
Sbjct: 19 LFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNE 78
Query: 67 DLQRVA----SSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTP 122
+ ++A ++R+H D + + V + A V+ V + + L+NN AGI+
Sbjct: 79 ETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSI--LINN---AGIVTGKK 133
Query: 123 WLTRDD--FQRVLNVNTMGPIGVTLALLP-LLQQARGRVINITSVLGRLAANG-GGYCVS 178
+L D ++ +VN + A LP ++ G ++ I+S G NG YC S
Sbjct: 134 FLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCAS 193
Query: 179 KFGLEAFSDSLRRDV---AHFGIRVSIVEPGFFRT 210
KF F++S+ + GI+ +IV P F +T
Sbjct: 194 KFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKT 228
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 67.8 bits (164), Expect = 1e-11
Identities = 58/201 (28%), Positives = 99/201 (49%), Gaps = 27/201 (13%)
Query: 31 VFITGCDSGFGRLLALQLDQRGFRVLASC----LTPSGAEDLQ-RVASSRLHTTLLDITD 85
V +TG ++G G+ AL+L +RG ++ +C + A+D++ + ++ LD+
Sbjct: 41 VIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLAS 100
Query: 86 PQSVQQ-AAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPIGVT 144
+S+++ AAK +E +E + L+NNAGV + W T D F+ VN +G +T
Sbjct: 101 LKSIREFAAKIIE---EEERVDILINNAGV---MRCPHWTTEDGFEMQFGVNHLGHFLLT 154
Query: 145 LALLPLLQ-QARGRVINITS---VLGRLAANG-----------GGYCVSKFGLEAFSDSL 189
LL L+ A R+IN++S V G + + YC SK + F+ L
Sbjct: 155 NLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKEL 214
Query: 190 RRDVAHFGIRVSIVEPGFFRT 210
R + G+ V+ + PG RT
Sbjct: 215 SRRLQGSGVTVNALHPGVART 235
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 65.9 bits (159), Expect = 5e-11
Identities = 56/227 (24%), Positives = 105/227 (46%), Gaps = 18/227 (7%)
Query: 3 LPLLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTP 62
LPLL+ L + + L ++ + V ITG G GRL A + + +++ +
Sbjct: 11 LPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINK 70
Query: 63 SGAEDLQ---RVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIG 119
G E+ + +++HT ++D ++ + + +AK V+ + + + LVNNAGV +
Sbjct: 71 HGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSI--LVNNAGV--VYT 126
Query: 120 PTPWLTRD-DFQRVLNVNTMGPIGVTLALLP-LLQQARGRVINITSVLGRLAANG-GGYC 176
+ T+D ++ VN + T A LP + + G ++ + S G ++ YC
Sbjct: 127 SDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYC 186
Query: 177 VSKFGLEAFSDSLRRDVAHF---GIRV-----SIVEPGFFRTPVTNL 215
SKF F +L ++A G++ + V GF + P T+L
Sbjct: 187 SSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSL 233
>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
Length = 316
Score = 65.9 bits (159), Expect = 5e-11
Identities = 68/239 (28%), Positives = 109/239 (45%), Gaps = 27/239 (11%)
Query: 21 RQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLT----PSGAEDLQ-RVASSR 75
R ++ V ITG ++G G+ A +L RG RV +C S A +++ +S+
Sbjct: 32 RTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQ 91
Query: 76 LHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNV 135
+ LD++D +S++ A+ +E L L+NNAGV ++ P T D F+ L V
Sbjct: 92 VLVRKLDLSDTKSIRAFAE--GFLAEEKQLHILINNAGV--MMCPYS-KTADGFETHLGV 146
Query: 136 NTMGPIGVTLALLPLLQ-QARGRVINITSV---LGRLA----------ANGGGYCVSKFG 181
N +G +T LL L+ A RV+N++SV +G++ + G YC SK
Sbjct: 147 NHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLA 206
Query: 182 LEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNLESLEKTLQACWARLPPATQAHYGGA 240
F+ L + + G+ V PG R+ + SL L W P + GA
Sbjct: 207 NVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSL---LCLLWRLFSPFVKTAREGA 262
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 65.9 bits (159), Expect = 5e-11
Identities = 54/186 (29%), Positives = 87/186 (46%), Gaps = 11/186 (5%)
Query: 33 ITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRVASSRLHTTLLDITDPQSVQQA 92
+ G G GR +A + ++G+R+ GA+ D+ VQ
Sbjct: 7 VFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNT 66
Query: 93 AKWVEMHVKEAGLFGLVNNAGVA--GIIGPTPWLTRDDFQRVLNVNTMGP-IGVTLALLP 149
+ +E H+ LVN AG+ G++ T +D L+ N +G + A+
Sbjct: 67 FEELEKHLGRVNF--LVNAAGINRDGLLVRTK---TEDMVSQLHTNLLGSMLTCKAAMRT 121
Query: 150 LLQQARGRVINITSVLGRLAANGGG--YCVSKFGLEAFSDSLRRDVAHFGIRVSIVEPGF 207
++QQ G ++N+ S++G L N G Y SK GL FS +L ++VA IRV++V PGF
Sbjct: 122 MIQQQGGSIVNVGSIVG-LKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGF 180
Query: 208 FRTPVT 213
T +T
Sbjct: 181 VHTDMT 186
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 65.1 bits (157), Expect = 8e-11
Identities = 51/177 (28%), Positives = 85/177 (48%), Gaps = 8/177 (4%)
Query: 31 VFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRVASSRLHTTLLDITDPQSVQ 90
V +TG G GR +A L + G V+ +T E LQ+V S L
Sbjct: 37 VIVTGASKGIGREMAYHLAKMGAHVV---VTARSKETLQKVVSHCLELGAASAHYIAGTM 93
Query: 91 QAAKWVEMHVKEAG-LFGLVNNAGVAGIIGPTPWLTRDDFQRV---LNVNTMGPIGVTLA 146
+ + E V +AG L G ++ + I + L DD V + VN + + +T+A
Sbjct: 94 EDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA 153
Query: 147 LLPLLQQARGRVINITSVLGRLA-ANGGGYCVSKFGLEAFSDSLRRDVAHFGIRVSI 202
LP+L+Q+ G ++ ++S+ G++A Y SKF L+ F S+R++ + + VSI
Sbjct: 154 ALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSI 210
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 65.1 bits (157), Expect = 8e-11
Identities = 51/177 (28%), Positives = 85/177 (48%), Gaps = 8/177 (4%)
Query: 31 VFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRVASSRLHTTLLDITDPQSVQ 90
V +TG G GR +A L + G V+ +T E LQ+V S L
Sbjct: 37 VIVTGASKGIGREMAYHLAKMGAHVV---VTARSKETLQKVVSHCLELGAASAHYIAGTM 93
Query: 91 QAAKWVEMHVKEAG-LFGLVNNAGVAGIIGPTPWLTRDDFQRV---LNVNTMGPIGVTLA 146
+ + E V +AG L G ++ + I + L DD V + VN + + +T+A
Sbjct: 94 EDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA 153
Query: 147 LLPLLQQARGRVINITSVLGRLA-ANGGGYCVSKFGLEAFSDSLRRDVAHFGIRVSI 202
LP+L+Q+ G ++ ++S+ G++A Y SKF L+ F S+R++ + + VSI
Sbjct: 154 ALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSI 210
>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
[Homo sapiens]
Length = 261
Score = 63.9 bits (154), Expect = 2e-10
Identities = 74/230 (32%), Positives = 98/230 (42%), Gaps = 35/230 (15%)
Query: 33 ITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRVASSRLHTTLLDITDPQSVQQA 92
ITG SG G A +L +G + L SG E + + D+T + VQ A
Sbjct: 15 ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTA 74
Query: 93 AKWVEMHVKEAGLFG----LVNNAGVAGIIGPTPWL------TRDDFQRVLNVNTMGPIG 142
+ G FG VN AG+A + T L T +DFQRVL+VN MG
Sbjct: 75 LALAK------GKFGRVDVAVNCAGIA-VASKTYNLKKGQTHTLEDFQRVLDVNLMGTFN 127
Query: 143 VTLALLPLLQQ-------ARGRVINITSVLGRLAANG-GGYCVSKFGLEAFSDSLRRDVA 194
V + + Q RG +IN SV G Y SK G+ + + RD+A
Sbjct: 128 VIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA 187
Query: 195 HFGIRVSIVEPGFFRTPVTNLESL-EKTLQACWARLP-------PATQAH 236
GIRV + PG F TP+ L SL EK +++P PA AH
Sbjct: 188 PIGIRVMTIAPGLFGTPL--LTSLPEKVCNFLASQVPFPSRLGDPAEYAH 235
>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
Length = 335
Score = 62.8 bits (151), Expect = 4e-10
Identities = 53/189 (28%), Positives = 92/189 (48%), Gaps = 16/189 (8%)
Query: 32 FITGCDSGFGRLLALQLDQRGFR-VLASC---LTPSGAEDLQRVASSRLHTTLLDITDPQ 87
FITG +G G+ + L G + V+AS + + AE + +++H D+ DP
Sbjct: 63 FITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPD 122
Query: 88 SVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPIGVTLAL 147
VQ V +K AG +V N I PT L+ + ++ + ++ G VTL +
Sbjct: 123 MVQNT---VSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEI 179
Query: 148 LPLLQQAR--GRVINITSVLGRLAANGGGYCV----SKFGLEAFSDSLRRDVAHFGIRVS 201
L +A+ ++IT++ A G G+ V +K G+EA S SL + +G+R +
Sbjct: 180 GKQLIKAQKGAAFLSITTIY---AETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFN 236
Query: 202 IVEPGFFRT 210
+++PG +T
Sbjct: 237 VIQPGPIKT 245
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 62.8 bits (151), Expect = 4e-10
Identities = 58/195 (29%), Positives = 94/195 (48%), Gaps = 24/195 (12%)
Query: 31 VFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQR-----VASSRLHTTLLDITD 85
V +TG ++G G+ A +L QRG RV +C E + + + ++ LD++D
Sbjct: 44 VVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSD 103
Query: 86 PQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPIGVTL 145
+S++ AK +E L L+NNAGV ++ P T D F+ + VN +G +T
Sbjct: 104 TKSIRAFAK--GFLAEEKHLHVLINNAGV--MMCPYS-KTADGFEMHIGVNHLGHFLLTH 158
Query: 146 ALLPLLQQ-ARGRVINITSV---LGRLAAN----------GGGYCVSKFGLEAFSDSLRR 191
LL L++ A R++N++S+ LGR+ + G YC SK F+ L R
Sbjct: 159 LLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELAR 218
Query: 192 DVAHFGIRVSIVEPG 206
+ G+ V PG
Sbjct: 219 RLKGSGVTTYSVHPG 233
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 62.0 bits (149), Expect = 7e-10
Identities = 51/184 (27%), Positives = 87/184 (47%), Gaps = 6/184 (3%)
Query: 31 VFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRVASSRLHTTLLDITDPQSVQ 90
V +TG G G + G RV+ SG L++ + L D+T V+
Sbjct: 12 VVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFI-LCDVTQEDDVK 70
Query: 91 QAAKWVEMHVKEAG-LFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPIGVTLALLP 149
V ++ G L +VNNAG + F+++L +N +G +T LP
Sbjct: 71 TL---VSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALP 127
Query: 150 LLQQARGRVINITSVLGRLA-ANGGGYCVSKFGLEAFSDSLRRDVAHFGIRVSIVEPGFF 208
L++++G VINI+S++G + A Y +K + A + +L D + +G+RV+ + PG
Sbjct: 128 YLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNI 187
Query: 209 RTPV 212
TP+
Sbjct: 188 WTPL 191
>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
Length = 302
Score = 60.1 bits (144), Expect = 3e-09
Identities = 64/215 (29%), Positives = 94/215 (43%), Gaps = 18/215 (8%)
Query: 31 VFITGCDSGFGRLLALQLDQRGFRVLA------SCLTPSGAEDLQRVASSRLHTTLLDIT 84
V ITG G GR LA + +RG R + CL + E R + H + D+
Sbjct: 41 VLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEE--IRQMGTECHYFICDVG 98
Query: 85 DPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDD-FQRVLNVNTMGPIGV 143
+ + V Q AK V V + + LVNNA V + G + + DD + ++NT+G
Sbjct: 99 NREEVYQTAKAVREKVGDITI--LVNNAAV--VHGKSLMDSDDDALLKSQHINTLGQFWT 154
Query: 144 TLALLP-LLQQARGRVINITSVLGRLAANGG-GYCVSKFGLEAFSDSLRRDVAHF-GIRV 200
T A LP +L+ G ++ + SVL A G YC SK AF +SL + G+
Sbjct: 155 TKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSA 214
Query: 201 SIVEPGFFRTPVTNLESLEKTLQACWARLPPATQA 235
+ V P F T + + + L P T A
Sbjct: 215 TTVLP--FHTSTEMFQGMRVRFPNLFPPLKPETVA 247
>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
Length = 341
Score = 59.7 bits (143), Expect = 3e-09
Identities = 66/244 (27%), Positives = 105/244 (43%), Gaps = 44/244 (18%)
Query: 5 LLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVL-------- 56
+L +L A WL+R ++ A + ITG SG GRL AL+ +R ++
Sbjct: 14 VLWAFVLAAARWLVRPKEKSVAGQVCL-ITGAGSGLGRLFALEFARRRALLVLWDINTQS 72
Query: 57 --------------------ASCLTPSGAEDLQRVASSRLHTTLLDITDPQSVQQAAKWV 96
A+ +G E++ + ++ T D+ ++V A+ V
Sbjct: 73 NEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERV 132
Query: 97 EMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDD-FQRVLNVNTMGPIGVTLALLP-LLQQA 154
V E + LVNNAGV + G D+ +R + VN T A LP +L+
Sbjct: 133 RKEVGEVSV--LVNNAGV--VSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEIN 188
Query: 155 RGRVINITSVLGRLAANG-GGYCVSKFGLEAFSDSLRRDV---AHFGIRVSIVEP----- 205
G ++ + S LG + G YC SKFG+ F +SL ++ GI+ ++V P
Sbjct: 189 HGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDT 248
Query: 206 GFFR 209
G FR
Sbjct: 249 GMFR 252
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.138 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,133,771
Number of Sequences: 37866
Number of extensions: 514535
Number of successful extensions: 1543
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 1448
Number of HSP's gapped (non-prelim): 74
length of query: 318
length of database: 18,247,518
effective HSP length: 102
effective length of query: 216
effective length of database: 14,385,186
effective search space: 3107200176
effective search space used: 3107200176
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.