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Search of human proteins with 50658082
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50658082 centrosomal protein 70 kDa [Homo sapiens]
(597 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50658082 centrosomal protein 70 kDa [Homo sapiens] 1173 0.0
gi|42794779 myosin 18A isoform b [Homo sapiens] 68 3e-11
gi|28416946 myosin 18A isoform a [Homo sapiens] 68 3e-11
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 67 4e-11
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 64 4e-10
gi|118498368 kinectin 1 isoform c [Homo sapiens] 64 5e-10
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 63 9e-10
gi|58535453 CDK5 regulatory subunit associated protein 2 isoform... 63 9e-10
gi|58535451 CDK5 regulatory subunit associated protein 2 isoform... 63 9e-10
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 63 9e-10
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 63 9e-10
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 62 1e-09
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 62 2e-09
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 61 3e-09
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 60 4e-09
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 60 7e-09
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens] 59 1e-08
gi|148746195 trichohyalin [Homo sapiens] 59 1e-08
gi|71061468 centromere protein E [Homo sapiens] 59 1e-08
gi|118498356 kinectin 1 isoform a [Homo sapiens] 58 2e-08
gi|33620775 kinectin 1 isoform a [Homo sapiens] 58 2e-08
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 58 2e-08
gi|239741279 PREDICTED: similar to FLJ00310 protein [Homo sapiens] 58 2e-08
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo... 57 4e-08
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo... 57 4e-08
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 57 4e-08
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 57 4e-08
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 57 4e-08
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 57 4e-08
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 57 4e-08
>gi|50658082 centrosomal protein 70 kDa [Homo sapiens]
Length = 597
Score = 1173 bits (3034), Expect = 0.0
Identities = 597/597 (100%), Positives = 597/597 (100%)
Query: 1 MFPVAPKPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDK 60
MFPVAPKPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDK
Sbjct: 1 MFPVAPKPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDK 60
Query: 61 QSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIME 120
QSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIME
Sbjct: 61 QSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIME 120
Query: 121 SVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVC 180
SVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVC
Sbjct: 121 SVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVC 180
Query: 181 RLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQS 240
RLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQS
Sbjct: 181 RLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQS 240
Query: 241 EEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYK 300
EEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYK
Sbjct: 241 EEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYK 300
Query: 301 QQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIH 360
QQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIH
Sbjct: 301 QQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIH 360
Query: 361 NPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAEL 420
NPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAEL
Sbjct: 361 NPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAEL 420
Query: 421 VPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVP 480
VPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVP
Sbjct: 421 VPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVP 480
Query: 481 SLNGVYPRMNEVYTRLGEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQV 540
SLNGVYPRMNEVYTRLGEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQV
Sbjct: 481 SLNGVYPRMNEVYTRLGEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQV 540
Query: 541 MQVLGPEDLQSIIYKLEEHEEFFPAFQAFTNDLLEILEIDDLDAIVPAVKKLKVLSY 597
MQVLGPEDLQSIIYKLEEHEEFFPAFQAFTNDLLEILEIDDLDAIVPAVKKLKVLSY
Sbjct: 541 MQVLGPEDLQSIIYKLEEHEEFFPAFQAFTNDLLEILEIDDLDAIVPAVKKLKVLSY 597
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 67.8 bits (164), Expect = 3e-11
Identities = 102/486 (20%), Positives = 197/486 (40%), Gaps = 60/486 (12%)
Query: 51 DLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQ 110
+ +D + ++Q+ +++ + L L ++ Q +Q+L + Q+L ELQ + Q+
Sbjct: 1392 EFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQV 1451
Query: 111 RANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEE 170
R ++LE+ S++ + +E A ++ + + LQ+E+ L + K++ E++
Sbjct: 1452 RNHELEKKQRRFDSELSQAHEE----AQREKLQREKLQREKDMLLAEAFSLKQQLEEKDM 1507
Query: 171 TIASLQMEVCRLKKEEEDRIVTQNRVFAYLCK------------RVPHTVLDRQLLCLID 218
IA +V L+ E +D +++ A L K + LD Q +
Sbjct: 1508 DIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQM 1567
Query: 219 YYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSS 278
++K+R + ++ S+ E D +A + + L ++ QL+E +
Sbjct: 1568 LEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLR 1627
Query: 279 EKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKL----QELINHKKAEDTEKKDEP 334
EK L+ L T Q R ++ + K+L K LK+ L Q +++H K K++
Sbjct: 1628 EKRELEGKLATLSDQVNRRDFESE-KRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIA 1686
Query: 335 SKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVP 394
NQ +++ F ++ + + E L
Sbjct: 1687 QLKNQ----LEESEFTCAAAVKA------------------------RKAMEVEIEDLHL 1718
Query: 395 VIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIK---------VEDLLFIVD 445
I+ A T+L++ L+ E+ L ++D NE +K DL I D
Sbjct: 1719 QIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQIND 1778
Query: 446 TMLE-EVENKEKDSNMPHFQTLQAIVSHF-QKLFDVPSLNGVYPRMNEVYTRLGEMNNAV 503
+ E NKEK Q LQ+ V Q + D ++ ++ E+ TRL V
Sbjct: 1779 LQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQV 1838
Query: 504 RNLQEL 509
+ L+ L
Sbjct: 1839 KRLESL 1844
Score = 48.5 bits (114), Expect = 2e-05
Identities = 59/290 (20%), Positives = 132/290 (45%), Gaps = 48/290 (16%)
Query: 59 DKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQ------QLRNELQLEQSRAANQEQRA 112
D +S +R+R++LK + Q M+ L + QL+N+L+ + A +
Sbjct: 1647 DFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKAR 1706
Query: 113 NDLEQIMESVKSKIGELE------DESLSRACHQQNKIKD-LQKEQKTLQVKCQHYKKKR 165
+E +E + +I ++ +E LSR ++N+I++ L+++Q+ + + +K
Sbjct: 1707 KAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAV 1766
Query: 166 TEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKR--VPHTVLDRQLLCLIDYYESK 223
+ +A + +L++ +++ Q ++ A + + +++D+ L + E+K
Sbjct: 1767 AQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSL---VSRQEAK 1823
Query: 224 IRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNL 283
IR++ T+ +++ + + E SL ++LKE+ EKL
Sbjct: 1824 IRELETRLEFERTQVKRLE------------------SLASRLKENM--------EKLTE 1857
Query: 284 QKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDE 333
++D E K+Q K+L++ L+ + + K+AE + KK E
Sbjct: 1858 ERDQRIAAENRE----KEQNKRLQRQLRDTKEEMGELARKEAEASRKKHE 1903
Score = 38.9 bits (89), Expect = 0.014
Identities = 48/213 (22%), Positives = 97/213 (45%), Gaps = 32/213 (15%)
Query: 80 QQNMIQELIETNQQLRNELQLEQSRAANQEQR----ANDLEQIMESVKSKIGELED---- 131
++N IQ +E +Q+ NEL + A Q R NDL+ +E + EL++
Sbjct: 1740 EKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQA 1799
Query: 132 -----ESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIAS-LQMEVCRLKKE 185
E L ++ ++ + + + + L+ + + +++ + ++ E++AS L+ + +L +E
Sbjct: 1800 LQSQVEFLEQSMVDKSLVSRQEAKIRELETRLE-FERTQVKRLESLASRLKENMEKLTEE 1858
Query: 186 EEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEEND 245
+ RI +NR ++ + L RQL + RK + + + E E D
Sbjct: 1859 RDQRIAAENR------EKEQNKRLQRQLRDTKEEMGELARK-----EAEASRKKHELEMD 1907
Query: 246 YRNLDASPTYKGLLMSLQNQLKESKSKIDALSS 278
+L+A+ SLQ LK + +I L +
Sbjct: 1908 LESLEAAN------QSLQADLKLAFKRIGDLQA 1934
Score = 37.0 bits (84), Expect = 0.052
Identities = 36/177 (20%), Positives = 79/177 (44%), Gaps = 18/177 (10%)
Query: 17 RLMTEKQQE----EAEWESINVLLMMH----GLKPLSLVKRTDLKDLIIFDKQSSQRMRQ 68
RL EK + E + E +N L+ H L + DL+ + + Q +++
Sbjct: 1736 RLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQE 1795
Query: 69 NLKLLVEETS-CQQNMIQELIETNQQ-----LRNELQLEQSRAANQEQRANDLEQIMESV 122
L+ L + +Q+M+ + + + Q+ L L+ E+++ E A+ L++ ME
Sbjct: 1796 KLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENME-- 1853
Query: 123 KSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEV 179
K+ E D+ ++ ++ + K LQ++ + + + +K E L+M++
Sbjct: 1854 --KLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDL 1908
Score = 30.8 bits (68), Expect = 3.7
Identities = 47/262 (17%), Positives = 110/262 (41%), Gaps = 17/262 (6%)
Query: 90 TNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQK 149
T + RN + +++ RA + DLE+ S + + + + A ++ + + +
Sbjct: 1133 TKKHGRNYIVVDERRAVEELLECLDLEK--SSCCMGLSRVFFRAGTLARLEEQRDEQTSR 1190
Query: 150 EQKTLQVKC------QHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKR 203
Q C QH+KK++ Q+ I +Q + KK + + ++F +
Sbjct: 1191 NLTLFQAACRGYLARQHFKKRKI-QDLAIRCVQKNI---KKNKGVKDWPWWKLFTTVRPL 1246
Query: 204 VPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQ 263
+ + + Q I + +I+++ ++ + E E N R L +
Sbjct: 1247 IEVQLSEEQ----IRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDER 1302
Query: 264 NQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHK 323
N + + +DA ++E+L +K+++ TQ++ + +V ++E + ++ E IN +
Sbjct: 1303 NTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAE-INGE 1361
Query: 324 KAEDTEKKDEPSKYNQQQALID 345
+D + KY + +D
Sbjct: 1362 VDDDDAGGEWRLKYERAVREVD 1383
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 67.8 bits (164), Expect = 3e-11
Identities = 102/486 (20%), Positives = 197/486 (40%), Gaps = 60/486 (12%)
Query: 51 DLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQ 110
+ +D + ++Q+ +++ + L L ++ Q +Q+L + Q+L ELQ + Q+
Sbjct: 1392 EFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQV 1451
Query: 111 RANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEE 170
R ++LE+ S++ + +E A ++ + + LQ+E+ L + K++ E++
Sbjct: 1452 RNHELEKKQRRFDSELSQAHEE----AQREKLQREKLQREKDMLLAEAFSLKQQLEEKDM 1507
Query: 171 TIASLQMEVCRLKKEEEDRIVTQNRVFAYLCK------------RVPHTVLDRQLLCLID 218
IA +V L+ E +D +++ A L K + LD Q +
Sbjct: 1508 DIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQM 1567
Query: 219 YYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSS 278
++K+R + ++ S+ E D +A + + L ++ QL+E +
Sbjct: 1568 LEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLR 1627
Query: 279 EKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKL----QELINHKKAEDTEKKDEP 334
EK L+ L T Q R ++ + K+L K LK+ L Q +++H K K++
Sbjct: 1628 EKRELEGKLATLSDQVNRRDFESE-KRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIA 1686
Query: 335 SKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVP 394
NQ +++ F ++ + + E L
Sbjct: 1687 QLKNQ----LEESEFTCAAAVKA------------------------RKAMEVEIEDLHL 1718
Query: 395 VIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIK---------VEDLLFIVD 445
I+ A T+L++ L+ E+ L ++D NE +K DL I D
Sbjct: 1719 QIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQIND 1778
Query: 446 TMLE-EVENKEKDSNMPHFQTLQAIVSHF-QKLFDVPSLNGVYPRMNEVYTRLGEMNNAV 503
+ E NKEK Q LQ+ V Q + D ++ ++ E+ TRL V
Sbjct: 1779 LQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQV 1838
Query: 504 RNLQEL 509
+ L+ L
Sbjct: 1839 KRLESL 1844
Score = 48.5 bits (114), Expect = 2e-05
Identities = 59/290 (20%), Positives = 132/290 (45%), Gaps = 48/290 (16%)
Query: 59 DKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQ------QLRNELQLEQSRAANQEQRA 112
D +S +R+R++LK + Q M+ L + QL+N+L+ + A +
Sbjct: 1647 DFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKAR 1706
Query: 113 NDLEQIMESVKSKIGELE------DESLSRACHQQNKIKD-LQKEQKTLQVKCQHYKKKR 165
+E +E + +I ++ +E LSR ++N+I++ L+++Q+ + + +K
Sbjct: 1707 KAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAV 1766
Query: 166 TEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKR--VPHTVLDRQLLCLIDYYESK 223
+ +A + +L++ +++ Q ++ A + + +++D+ L + E+K
Sbjct: 1767 AQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSL---VSRQEAK 1823
Query: 224 IRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNL 283
IR++ T+ +++ + + E SL ++LKE+ EKL
Sbjct: 1824 IRELETRLEFERTQVKRLE------------------SLASRLKENM--------EKLTE 1857
Query: 284 QKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDE 333
++D E K+Q K+L++ L+ + + K+AE + KK E
Sbjct: 1858 ERDQRIAAENRE----KEQNKRLQRQLRDTKEEMGELARKEAEASRKKHE 1903
Score = 42.4 bits (98), Expect = 0.001
Identities = 53/247 (21%), Positives = 111/247 (44%), Gaps = 35/247 (14%)
Query: 80 QQNMIQELIETNQQLRNELQLEQSRAANQEQR----ANDLEQIMESVKSKIGELED---- 131
++N IQ +E +Q+ NEL + A Q R NDL+ +E + EL++
Sbjct: 1740 EKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQA 1799
Query: 132 -----ESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIAS-LQMEVCRLKKE 185
E L ++ ++ + + + + L+ + + +++ + ++ E++AS L+ + +L +E
Sbjct: 1800 LQSQVEFLEQSMVDKSLVSRQEAKIRELETRLE-FERTQVKRLESLASRLKENMEKLTEE 1858
Query: 186 EEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEEND 245
+ RI +NR ++ + L RQL + RK + + + E E D
Sbjct: 1859 RDQRIAAENR------EKEQNKRLQRQLRDTKEEMGELARK-----EAEASRKKHELEMD 1907
Query: 246 YRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKK 305
+L+A+ SLQ LK + +I L + ++ ++E+ + + + V K
Sbjct: 1908 LESLEAAN------QSLQADLKLAFKRIGDLQAA---IEDEMESDENEDLINSLQDMVTK 1958
Query: 306 LEKALKK 312
+K K
Sbjct: 1959 YQKRKNK 1965
Score = 37.0 bits (84), Expect = 0.052
Identities = 36/177 (20%), Positives = 79/177 (44%), Gaps = 18/177 (10%)
Query: 17 RLMTEKQQE----EAEWESINVLLMMH----GLKPLSLVKRTDLKDLIIFDKQSSQRMRQ 68
RL EK + E + E +N L+ H L + DL+ + + Q +++
Sbjct: 1736 RLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQE 1795
Query: 69 NLKLLVEETS-CQQNMIQELIETNQQ-----LRNELQLEQSRAANQEQRANDLEQIMESV 122
L+ L + +Q+M+ + + + Q+ L L+ E+++ E A+ L++ ME
Sbjct: 1796 KLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENME-- 1853
Query: 123 KSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEV 179
K+ E D+ ++ ++ + K LQ++ + + + +K E L+M++
Sbjct: 1854 --KLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDL 1908
Score = 30.8 bits (68), Expect = 3.7
Identities = 47/262 (17%), Positives = 110/262 (41%), Gaps = 17/262 (6%)
Query: 90 TNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQK 149
T + RN + +++ RA + DLE+ S + + + + A ++ + + +
Sbjct: 1133 TKKHGRNYIVVDERRAVEELLECLDLEK--SSCCMGLSRVFFRAGTLARLEEQRDEQTSR 1190
Query: 150 EQKTLQVKC------QHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKR 203
Q C QH+KK++ Q+ I +Q + KK + + ++F +
Sbjct: 1191 NLTLFQAACRGYLARQHFKKRKI-QDLAIRCVQKNI---KKNKGVKDWPWWKLFTTVRPL 1246
Query: 204 VPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQ 263
+ + + Q I + +I+++ ++ + E E N R L +
Sbjct: 1247 IEVQLSEEQ----IRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDER 1302
Query: 264 NQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHK 323
N + + +DA ++E+L +K+++ TQ++ + +V ++E + ++ E IN +
Sbjct: 1303 NTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAE-INGE 1361
Query: 324 KAEDTEKKDEPSKYNQQQALID 345
+D + KY + +D
Sbjct: 1362 VDDDDAGGEWRLKYERAVREVD 1383
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 67.4 bits (163), Expect = 4e-11
Identities = 67/289 (23%), Positives = 134/289 (46%), Gaps = 27/289 (9%)
Query: 71 KLLVEETSCQQNMIQELIETNQQLRNEL--QLEQSRAANQEQRANDLEQIMESVKSKIGE 128
K L EE + IQE+ + + Q EL QLEQ++ +AN LE+ ++++++ GE
Sbjct: 1174 KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRV----KAN-LEKAKQTLENERGE 1228
Query: 129 LEDE---SLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQME---VCRL 182
L +E L ++K K ++ + + LQVK ++ RTE + + LQ+E V L
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL 1288
Query: 183 KKEEEDRIVTQNRVFAYLCKRVPHT-----VLDRQLLCLIDYYESKIRKIHTQRQYKEDE 237
+ + + + F+ L ++ T +RQ L L +K++++ ++ ++
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL----STKLKQVEDEKNSFREQ 1344
Query: 238 SQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELR 297
+ EEE + T + ++ ++++S ++ K LQKDLE +HE
Sbjct: 1345 LEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE-- 1402
Query: 298 LYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQ 346
++V +K K +LQ+ ++ + ++ ++Q DQ
Sbjct: 1403 ---EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQ 1448
Score = 63.9 bits (154), Expect = 4e-10
Identities = 103/514 (20%), Positives = 216/514 (42%), Gaps = 65/514 (12%)
Query: 50 TDLKDLIIFDKQSSQRMRQNLKLLV--EETSCQQNMIQELIETNQQLRNE-LQLEQSRAA 106
T +K L+ +Q + M + +L+ E+ +N + E+ QL E LQL++ A
Sbjct: 832 TKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQA 891
Query: 107 NQE--QRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKK 164
E A +L + + K ++ E+ + +R ++ + + LQ E+K +Q Q +++
Sbjct: 892 ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951
Query: 165 RTEQEETIASLQME----VCRLKKEEEDRIV--------------TQNRVFAYLCKRVPH 206
E+E LQ+E +LKK EE++I+ ++R+ +
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 207 TVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQL 266
+ L L + +E+ I + +R +E++ + E E R L+ T L +Q+
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLE-ERLRREEKQRQELEKTRRKLEGDST------DLSDQI 1064
Query: 267 KESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAE 326
E +++I L + +++L Q L +++ + ALKK +L+ I+ + +
Sbjct: 1065 AELQAQIAELKMQLAKKEEEL-----QAALARVEEEAAQKNMALKKIRELESQISELQED 1119
Query: 327 DTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRA----------PVIIYKQTKGGV 376
++ +K +Q+ + + + + + + A V I K+T
Sbjct: 1120 LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179
Query: 377 QNFNKDLVQDCGFEHLVPVIEMWADQLTSLK----DLYKSLKT-------LSAELVPWLN 425
++ +Q+ +H V E+ A+QL K +L K+ +T L+ E+ L
Sbjct: 1180 AKTHEAQIQEMRQKHSQAVEEL-AEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQ 1238
Query: 426 LKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGV 485
K E++ KVE L+E++ K + + + +L +V L
Sbjct: 1239 GKGDSEHKRKKVE-------AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 486 YPRMNEVYTR-LGEMNNAVRNLQELLELDSSSSL 518
+ T+ + + +++ QELL+ ++ L
Sbjct: 1292 SDSKSSKLTKDFSALESQLQDTQELLQEENRQKL 1325
Score = 44.3 bits (103), Expect = 3e-04
Identities = 72/343 (20%), Positives = 139/343 (40%), Gaps = 68/343 (19%)
Query: 17 RLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSS------QRMRQNL 70
R + E +++AE E +N RT+++DL+ ++ ++ L
Sbjct: 1483 RALEEAMEQKAELERLNKQF------------RTEMEDLMSSKDDVGKSVHELEKSKRAL 1530
Query: 71 KLLVEETSCQQNMIQELIETNQ--QLRNELQLEQSRA-------ANQEQRANDLEQIMES 121
+ VEE Q +++ ++ + +LR E+ L+ +A EQ +Q++
Sbjct: 1531 EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQ 1590
Query: 122 VKSKIGELEDESLSRAC------------------------HQQNKIKDLQKEQKTLQVK 157
V+ ELEDE R+ ++ IK L+K Q ++
Sbjct: 1591 VREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDC 1650
Query: 158 CQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRV-FAYLCKRVPHTVLDRQLLCL 216
+ R +EE +A + +LK E + I Q + A KR D +
Sbjct: 1651 MRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710
Query: 217 IDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDAL 276
+ + +R+ + +Q EEE + +G + ++LK++ +ID +
Sbjct: 1711 ANSSGKGALALEEKRRLEARIAQLEEELEEE--------QGNTELINDRLKKANLQIDQI 1762
Query: 277 SSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQEL 319
+++ LNL+ R + +QQ+++ K LK VKLQE+
Sbjct: 1763 NTD-LNLE-----RSHAQKNENARQQLERQNKELK--VKLQEM 1797
Score = 41.6 bits (96), Expect = 0.002
Identities = 64/327 (19%), Positives = 134/327 (40%), Gaps = 47/327 (14%)
Query: 47 VKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQ---- 102
VKR KDL ++ +++ KL +T QQ + L++ + Q ++ LE+
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Query: 103 ------------SRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKE 150
++ A + RA + E+ + +E++ + + K + E
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 151 QKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKK-----EEEDRIVTQNRVFAYLCKRVP 205
+ L K E E++ +L+ +V +K E+E + ++ + +
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565
Query: 206 HTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQ 265
+R L + E K +++ RQ +E E++ E+E R++ + K L+
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQL--VRQVREMEAELEDERKQRSMAVAARKK-----LEMD 1618
Query: 266 LKESKSKIDALSSEKLNLQKDL---------------ETRPTQHE-LRLYKQQVKKLEKA 309
LK+ ++ ID+ + + K L +TR ++ E L K+ KKL+
Sbjct: 1619 LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSM 1678
Query: 310 LKKNVKLQELI---NHKKAEDTEKKDE 333
+ ++LQE + K + +++DE
Sbjct: 1679 EAEMIQLQEELAAAERAKRQAQQERDE 1705
Score = 39.7 bits (91), Expect = 0.008
Identities = 45/197 (22%), Positives = 94/197 (47%), Gaps = 29/197 (14%)
Query: 93 QLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQK 152
QL EL+ EQ R ++ + + + LE S A +N + L+++ K
Sbjct: 1733 QLEEELEEEQGNTELINDRLKKANLQIDQINTDLN-LER---SHAQKNENARQQLERQNK 1788
Query: 153 TLQVKCQHYKKK-RTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDR 211
L+VK Q + +++ + +I +L+ ++ +L+++ ++ T+ R A CK+V T
Sbjct: 1789 ELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNE--TKERQAA--CKQVRRT---- 1840
Query: 212 QLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKS 271
E K++ + Q +DE ++ E+ Y+ D + L L+ QL+E++
Sbjct: 1841 ---------EKKLKDVLLQ---VDDERRNAEQ--YK--DQADKASTRLKQLKRQLEEAEE 1884
Query: 272 KIDALSSEKLNLQKDLE 288
+ ++ + LQ++LE
Sbjct: 1885 EAQRANASRRKLQRELE 1901
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 63.9 bits (154), Expect = 4e-10
Identities = 103/497 (20%), Positives = 210/497 (42%), Gaps = 87/497 (17%)
Query: 7 KPQDSSQPSDRLMTEKQQEEA--EWESINVLLMMHGLKPLSLVKRTDLKDLI-------- 56
K Q + S++ ++Q +E E E I L M K ++ ++ D K+LI
Sbjct: 306 KEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLR--DAKNLIEQLEQDKG 363
Query: 57 IFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLE 116
+ ++ ++M + L++ EE + ++ I+++ ++LR + + + A + ++A
Sbjct: 364 MVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTA 423
Query: 117 QIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQ 176
Q E + K+ DE + KT++ +T +EE I SLQ
Sbjct: 424 QKTEEARRKLKAEMDEQI-----------------KTIE---------KTSEEERI-SLQ 456
Query: 177 MEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKED 236
E+ R+K+E D + + +++ L R+ L +++ R+ Q + +
Sbjct: 457 QELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALE 516
Query: 237 ESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQK-------DLET 289
+SQSE ++ + K + ++L+ E+L LQK + +
Sbjct: 517 KSQSE---------------------YLKISQEKEQQESLALEELELQKKAILTESENKL 555
Query: 290 RPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYF 349
R Q E Y+ ++ +LE +L+K+ LQE N K + E +K+N++ ++ +++
Sbjct: 556 RDLQQEAETYRTRILELESSLEKS--LQENKNQSKDLAVHLEAEKNKHNKEITVMVEKH- 612
Query: 350 QVLCSINSIIHNPRA----PVIIYKQ--------TKGGVQNFNKDLVQDCGFEHLVPVIE 397
+ S+ H A + + KQ + + + L++D + E
Sbjct: 613 --KTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670
Query: 398 MWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKD 457
M L L L++LS+EL L + + E E ++D D M +E+E K +
Sbjct: 671 MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQ---TDKMKQELEAKMDE 727
Query: 458 SNMPHFQTLQAIVSHFQ 474
H Q + +I+ +
Sbjct: 728 QKNHHQQQVDSIIKEHE 744
Score = 54.3 bits (129), Expect = 3e-07
Identities = 88/383 (22%), Positives = 169/383 (44%), Gaps = 80/383 (20%)
Query: 7 KPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDL-IIFDKQSSQR 65
K Q + +++L KQQ + E E + + K T LKD IIF +
Sbjct: 620 KHQQDALWTEKLQVLKQQYQTEMEKLR--------EKCEQEKETLLKDKEIIFQAHIEEM 671
Query: 66 MRQNL-KLLVEETSCQQ--NMIQELIETNQQLRNEL--------QLEQSRAANQEQRAND 114
+ L KL V++T + + + E+++ +L EL +++Q A +++ N
Sbjct: 672 NEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH 731
Query: 115 LEQIMESV---------------KSKIGELE------DESLSR-ACHQQNKIKDLQKEQK 152
+Q ++S+ K +I +LE D+ L H +N D+++ +
Sbjct: 732 HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG 791
Query: 153 TLQVKC------QHYKKKRTEQ----EETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCK 202
LQ Q Y+ EQ EE +A LQ ++ L E +RI+ L K
Sbjct: 792 ELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDL---ETERIL--------LTK 840
Query: 203 RVPHTVLDRQLLCL-IDYYESKIRKIHTQRQYKEDESQS---------EEENDYRNLDAS 252
+V ++ +C +D ++ +++ + Q + + E + E + + N +
Sbjct: 841 QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
Query: 253 PTYKGLLMSLQN---QLKESKSKIDALSSEKLNLQKD-LETRPTQHELRLYKQQVKKLEK 308
T K +L+ +N Q++E + K + ++KL+ ++D + ++E + +K Q KK+EK
Sbjct: 901 QT-KQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETK-FKNQEKKMEK 958
Query: 309 ALKKNVKLQELINHKKAEDTEKK 331
+K ++QE + KK D E K
Sbjct: 959 VKQKAKEMQETLK-KKLLDQEAK 980
Score = 52.8 bits (125), Expect = 9e-07
Identities = 81/347 (23%), Positives = 149/347 (42%), Gaps = 62/347 (17%)
Query: 19 MTEKQQEEAEWESINVLLM----------MHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQ 68
+ EK+QE AE + +LL + LK + + T L +L +Q Q+
Sbjct: 1066 LQEKEQEVAELKQ-KILLFGCEKEEMNKEITWLKEEGVKQDTTLNEL---QEQLKQKSAH 1121
Query: 69 NLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGE 128
L +ET + ++ + ++ N+ L+ L++ +L+ + E K K+ E
Sbjct: 1122 VNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLV--------ELKMLAEEDKRKVSE 1173
Query: 129 LEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKE--- 185
L + + Q+ +K K+L+ K +KK E ++Q+++C K E
Sbjct: 1174 LTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEE-----LAIQLDICCKKTEALL 1228
Query: 186 ----EEDRIVTQNRVFAYLCKRVPH-----TVLDRQLL---CLIDYYESKIRKIHTQRQY 233
E ++ ++ A L R+ H T + LL C + E+++R++
Sbjct: 1229 EAKTNELINISSSKTNAIL-SRISHCQHRTTKVKEALLIKTCTVSELEAQLRQL------ 1281
Query: 234 KEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQ 293
+EE+N T++ L +NQ+K K+ I++L +EK LQK E Q
Sbjct: 1282 ------TEEQNTLNISFQQATHQ--LEEKENQIKSMKADIESLVTEKEALQK--EGGNQQ 1331
Query: 294 HELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQ 340
+ + +L+K L +N+ L+ K E EKK E S ++Q
Sbjct: 1332 QAASEKESCITQLKKELSENINAVTLM---KEELKEKKVEISSLSKQ 1375
Score = 51.2 bits (121), Expect = 3e-06
Identities = 134/597 (22%), Positives = 247/597 (41%), Gaps = 121/597 (20%)
Query: 80 QQNMIQELIETNQQ----LRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELED---- 131
Q N+++E ++ + L+ E++ ++S+ E++ ++LE ++S ++I ELED
Sbjct: 1480 QINLLKEELDQQNKRFDCLKGEMEDDKSK---MEKKESNLETELKSQTARIMELEDHITQ 1536
Query: 132 -----ESLSRACHQQNKIKDLQKEQKTLQVKCQHYKK-------KRTEQEETIASLQMEV 179
ESL+ N+ KD+ E K L K QH+++ + E EE I +L+ +V
Sbjct: 1537 KTIEIESLNEVLKNYNQQKDI--EHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQV 1594
Query: 180 CRLK-------------------KEEE-----DRIVTQNRVFAYLCKRVPH---TVLDRQ 212
+K KEEE DR+ +++ KR + +Q
Sbjct: 1595 YSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQ 1654
Query: 213 LLCLIDYYESKIRK--------IHTQRQYKEDE-------------SQSE---------- 241
LL ++ E + +K ++T+ Q +E E SQSE
Sbjct: 1655 LLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKN 1714
Query: 242 -------EENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQH 294
EE D + TY+ + LQ L E + + + EK ET +
Sbjct: 1715 VAAYTEQEEADSQGC-VQKTYEEKISVLQRNLTEKEKLLQRVGQEKE------ETVSSHF 1767
Query: 295 ELRL-YKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALID--QRYFQV 351
E+R Y++++ KLE A K + Q +I H + E EK + S Q + + Q
Sbjct: 1768 EMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQA 1827
Query: 352 LCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYK 411
++ ++ + + + + T ++ K+L + V +EM ++LTS + +
Sbjct: 1828 KQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEM--EELTSKYEKLQ 1885
Query: 412 SLKTLSAELVPWLNLKKQDENEG---IKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQA 468
+L+ + P L++ E + + LL ++ ++E K + Q L
Sbjct: 1886 ALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREK-QKLGK 1944
Query: 469 IVSHFQKLFDVPSLNGVYPRMNEVYTRL--GEMNNAVRNLQELLELDSSSSLCVLVSTVG 526
+ QK D+ L + + E+ + E ++ QE LEL + ST+
Sbjct: 1945 EIVRLQK--DLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHN-------STLK 1995
Query: 527 KLCRLINEDVNEQVMQVLGPEDLQSIIYKLEEHE-EFFPAFQAFTNDLL-EILEIDD 581
+L R N + ++ ++ ++ I K +E E E + Q TN LL +I E DD
Sbjct: 1996 QLMREFNTQLAQKEQEL--EMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDD 2050
Score = 49.3 bits (116), Expect = 1e-05
Identities = 76/344 (22%), Positives = 141/344 (40%), Gaps = 45/344 (13%)
Query: 21 EKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQ 80
EKQ E E + +K L+ V + L+D +Q+ Q + + ++++ Q
Sbjct: 871 EKQNSEMEQK----------VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQ 920
Query: 81 QNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQ 140
+ I+ L + + + + E + + E+ ME VK K E+++ + Q
Sbjct: 921 KKEIEILTQKLSAKEDSIHILNEE---YETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQ 977
Query: 141 QNKIK-DLQKEQKTLQVKCQHYKKKRTEQEET-IASLQMEVCRLKKEEEDRIVTQNRVFA 198
+ K+K +L+ L K + + K E + A + V RL+ ++++I + V
Sbjct: 978 EAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR 1037
Query: 199 YLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGL 258
R+L +I +E K+ + + Q + E+E + L G
Sbjct: 1038 ------------RELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGC 1085
Query: 259 LMSLQNQ----LKESKSKIDALSSEKLNLQKDLETRPT------QHELRLYKQQVKKLE- 307
N+ LKE K D +E LQ+ L+ + Q E +L K ++KLE
Sbjct: 1086 EKEEMNKEITWLKEEGVKQDTTLNE---LQEQLKQKSAHVNSLAQDETKL-KAHLEKLEV 1141
Query: 308 ---KALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRY 348
K+LK+N LQE + K E K + S+ + D+ +
Sbjct: 1142 DLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEF 1185
Score = 47.4 bits (111), Expect = 4e-05
Identities = 68/327 (20%), Positives = 140/327 (42%), Gaps = 40/327 (12%)
Query: 50 TDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAA--- 106
T LK + + + M++ LK E S ++ ++L + N QL+N + L + AA
Sbjct: 1342 TQLKKELSENINAVTLMKEELKEKKVEIS---SLSKQLTDLNVQLQNSISLSEKEAAISS 1398
Query: 107 ----NQEQRANDLEQIMESVKSKIGELEDESLSRACHQ---------------QNKIKDL 147
E++ L+Q+ + + K+ L E +S A Q Q++
Sbjct: 1399 LRKQYDEEKCELLDQVQD-LSFKVDTLSKEKIS-ALEQVDDWSNKFSEWKKKAQSRFTQH 1456
Query: 148 QKEQKTLQVKCQHYKKKRTEQEETIASLQMEV--------CRLKKEEEDRIVTQNRVFAY 199
Q K LQ++ + K+ E++E I L+ E+ C + E+D+ + +
Sbjct: 1457 QNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL 1516
Query: 200 LCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLL 259
+ T +++ L D+ K +I + + ++ +Q ++ + ++ L
Sbjct: 1517 ETELKSQTA---RIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELG 1573
Query: 260 MSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQEL 319
N++KE++ KI L ++ +++ +LET+ + EL VK E+ LK E
Sbjct: 1574 EEKDNRVKEAEEKILTLENQVYSMKAELETK--KKELEHVNLSVKSKEEELKALEDRLES 1631
Query: 320 INHKKAEDTEKKDEPSKYNQQQALIDQ 346
+ K + ++K E ++ L+ Q
Sbjct: 1632 ESAAKLAELKRKAEQKIAAIKKQLLSQ 1658
Score = 38.5 bits (88), Expect = 0.018
Identities = 68/334 (20%), Positives = 148/334 (44%), Gaps = 59/334 (17%)
Query: 21 EKQQEEAEWESINVLLMMHGLKPLS-LVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSC 79
E +++E E +++V LK L ++ L +++ Q++ K L+ +
Sbjct: 1602 ETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEE 1661
Query: 80 QQNMIQELIETN-QQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGE---LEDESLS 135
++ ++ E++ +L +LQ +E+ + LE+ ++SV+S E + + +
Sbjct: 1662 KEEQYKKGTESHLSELNTKLQ-------EREREVHILEEKLKSVESSQSETLIVPRSAKN 1714
Query: 136 RACHQQNKIKDLQK-EQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQN 194
A + + + D Q QKT + K ++ TE+E+ + R+ +E+E+ + +
Sbjct: 1715 VAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQ-------RVGQEKEETVSSH- 1766
Query: 195 RVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQS---EEENDYRNLDA 251
F C+ Y E I+ H + + ED+S +EE + +N
Sbjct: 1767 --FEMRCQ----------------YQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKY 1808
Query: 252 SPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHEL--RLYKQQVKKLEKA 309
S L+++ + + K+ I A + + N+ D++ + EL ++ +Q++K+L+
Sbjct: 1809 S-----LIVAQHVEKEGGKNNIQAKQNLE-NVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
Query: 310 LKKNVKLQELINHKKAEDTEKKDEPSKYNQQQAL 343
L + K+ E ++ SKY + QAL
Sbjct: 1863 L---------VRQKEVHRVEMEELTSKYEKLQAL 1887
Score = 37.0 bits (84), Expect = 0.052
Identities = 45/202 (22%), Positives = 99/202 (49%), Gaps = 26/202 (12%)
Query: 18 LMTEKQQE----EAEWESINVLLMMHGLKPLSLVKRTDLKDLII-FDKQSSQRMRQNLKL 72
L E QQE + E++ + + L L + LK L+ F+ Q +Q+ Q L++
Sbjct: 1956 LRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK-EQELEM 2014
Query: 73 LVEET-SCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELED 131
++ET + Q + EL+E++Q+ N+L + + ++ +DL++ + + + E+
Sbjct: 2015 TIKETINKAQEVEAELLESHQEETNQLLKKIA------EKDDDLKRTAKRYEEILDAREE 2068
Query: 132 ESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKE--EEDR 189
E + K++DLQ + + LQ K Q ++ EQEE + + + L+ + ++
Sbjct: 2069 EMTA-------KVRDLQTQLEELQKKYQ----QKLEQEENPGNDNVTIMELQTQLAQKTT 2117
Query: 190 IVTQNRVFAYLCKRVPHTVLDR 211
+++ +++ + H + DR
Sbjct: 2118 LISDSKLKEQEFREQIHNLEDR 2139
Score = 34.7 bits (78), Expect = 0.26
Identities = 80/407 (19%), Positives = 158/407 (38%), Gaps = 87/407 (21%)
Query: 4 VAPKPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSS 63
V K ++ DRL +E + AE L + ++ +K+ L + ++Q
Sbjct: 1615 VKSKEEELKALEDRLESESAAKLAE-------LKRKAEQKIAAIKKQLLSQMEEKEEQYK 1667
Query: 64 QRMRQNLKLL---VEETSCQQNMIQELIETNQQLRNELQLEQSRAAN-----QEQRANDL 115
+ +L L ++E + ++++E +++ + ++E + A N +++ A+
Sbjct: 1668 KGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQ 1727
Query: 116 EQIMESVKSKIGEL-----EDESLSRACHQQNKIK-----DLQKEQKTLQVKCQHYKKKR 165
+ ++ + KI L E E L + Q+ + +++ + + +K +H + K+
Sbjct: 1728 GCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQ 1787
Query: 166 TEQEETIASLQMEVCRLKKEEEDRIVTQN-----------------RVFAYLCKRVPHTV 208
E + I LQ E+ K ++ IV Q+ VF + K +
Sbjct: 1788 HEDQSMIGHLQEEL-EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE 1846
Query: 209 LDRQLL---------CLIDYYE----------SKIRKIHTQRQYKEDESQSE--EENDYR 247
L Q+L CL+ E SK K+ +Q +E EEN
Sbjct: 1847 LTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEE 1906
Query: 248 NLDASPTYKGLLMSLQNQLKESKSKIDALSSEK-------LNLQKDLETRPTQHELRL-- 298
+ LL +++ Q + + K+ EK + LQKDL +H+ L
Sbjct: 1907 KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEI 1966
Query: 299 ------------YKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDE 333
KQ+ + LE LK N L++L+ + +K+ E
Sbjct: 1967 LKKEYDQEREEKIKQEQEDLE--LKHNSTLKQLMREFNTQLAQKEQE 2011
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 63.5 bits (153), Expect = 5e-10
Identities = 111/535 (20%), Positives = 227/535 (42%), Gaps = 69/535 (12%)
Query: 59 DKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQI 118
DKQ Q +L + + ++ ++++ N L+ E+Q Q+ A Q A++LE++
Sbjct: 613 DKQIKQT-EDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKM 671
Query: 119 MESV---KSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASL 175
+SV KI LE++ ++ + K L + K L+ + Q + +EQ
Sbjct: 672 QQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVE 731
Query: 176 QMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQ--Y 233
QME C +K+E+ + V + +L+ L+ + E ++ I T+
Sbjct: 732 QMEKCIQEKDEKLKTVEE--------------LLETGLI-QVATKEEELNAIRTENSSLT 776
Query: 234 KEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKI----DALSSEKLNL-QKDLE 288
KE + ++ND ++ L+ L+ + E KI + L +E L + K+
Sbjct: 777 KEVQDLKAKQND------QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKT 830
Query: 289 TRPTQHELRLYKQQV--KKLEKALKKNV--KLQELINHKKAEDTEKKDEPSKYNQQQALI 344
+ + E++ K+++ +LEKA + ++ K+QEL N K ++ + N +A++
Sbjct: 831 VQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKE-------EQMNTMKAVL 883
Query: 345 DQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLT 404
+++ + + + + + Q+ K+ FE L V++ ++
Sbjct: 884 EEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLK---EKEN 940
Query: 405 SLKDLYKSLKTLSAELVPWLNLKK--QDENEGIK--VEDLLFIVDTMLEEVENKEKDSNM 460
LK L LK ++L L + QDEN+ K +E L + +N ++ S+
Sbjct: 941 ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQL---------KQQNYQQASSF 991
Query: 461 PHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRLGEMNNAVRNLQELLELDSSSSLCV 520
P + L ++S +K ++ L + + + NN + E +EL++ L
Sbjct: 992 PPHEELLKVISEREK--EISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKK 1049
Query: 521 LVSTV--------GKLCRLINEDVNEQVMQVLGPEDLQSIIYKLEEHEEFFPAFQ 567
L V G+ + E + G E+++ + +KL+E +E Q
Sbjct: 1050 LFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQ 1104
Score = 54.7 bits (130), Expect = 2e-07
Identities = 92/481 (19%), Positives = 212/481 (44%), Gaps = 38/481 (7%)
Query: 4 VAPKPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDL-KDLIIFDKQS 62
+A +D++ DR Q+ E E NV++ + +L K ++ ++ I Q
Sbjct: 341 LAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE 400
Query: 63 SQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNEL-----QLEQSRAANQEQRANDLEQ 117
+Q+M+ + + E+ + I L + N LR+ + QLE ++A + D +
Sbjct: 401 TQQMQMKFQQVREQMEAE---IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYAR 457
Query: 118 IMESVKSKIGELEDESLSRACHQQ--NKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASL 175
++ + K G+L+ E + + +Q ++K +E + + Q Y +KRT + E A
Sbjct: 458 LVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEA-AQQ 516
Query: 176 QMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRK-----IHTQ 230
++ + KE E + + + K+ L+++L+ L++ + ++ K + Q
Sbjct: 517 DLQSKFVAKENEVQSLHSKLTDTLVSKQ----QLEQRLMQLMESEQKRVNKEESLQMQVQ 572
Query: 231 RQYKEDESQSEEENDYRNLDASPTYKGLLMS-----LQNQLKESKSKIDALSSEKLNL-Q 284
+++E+ + + + A+ T +L + + K+ K D+L+SE+ L
Sbjct: 573 DILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 632
Query: 285 KDLETRPTQHELRLYKQQVKKLEK-ALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQAL 343
K+ E + Q+ L K +V+KL+ A ++ EL K + KD+ + ++Q
Sbjct: 633 KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL--EKMQQSVYVKDDKIRLLEEQLQ 690
Query: 344 ID----QRYFQVLCSINSIIHN--PRAPVIIYKQTKGGVQNFNKDLVQ--DCGFEHLVPV 395
+ F++L N + + + ++ +Q V + +Q D + + +
Sbjct: 691 HEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEEL 750
Query: 396 IEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKE 455
+E Q+ + ++ +++T ++ L + K +N+ + L+ + ++ E + K
Sbjct: 751 LETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI 810
Query: 456 K 456
K
Sbjct: 811 K 811
Score = 37.7 bits (86), Expect = 0.030
Identities = 44/206 (21%), Positives = 80/206 (38%), Gaps = 15/206 (7%)
Query: 141 QNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYL 200
++K+K+ + LQ++C+ YK E E + LQ V ++EE V + +
Sbjct: 1090 EHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSV---EQEENKWKVKVDESHKTI 1146
Query: 201 CKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLM 260
+ Q L + I + +R++ E E + E TY +
Sbjct: 1147 KQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEME-------RSTYVTEVR 1199
Query: 261 SLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELI 320
L+ QL E+ +K+ +E+ + DL Q L L + K+ KA ++
Sbjct: 1200 ELKAQLNETLTKLRTEQNERQKVAGDL--HKAQQSLELIQ---SKIVKAAGDTTVIENSD 1254
Query: 321 NHKKAEDTEKKDEPSKYNQQQALIDQ 346
+ E +EK+ NQ + Q
Sbjct: 1255 VSPETESSEKETMSVSLNQTVTQLQQ 1280
Score = 30.8 bits (68), Expect = 3.7
Identities = 30/136 (22%), Positives = 61/136 (44%), Gaps = 21/136 (15%)
Query: 75 EETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDES- 133
EE ++ ++E E + L+ E + +S A E L++ +E ++K DES
Sbjct: 1084 EEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESH 1143
Query: 134 ----------------LSRACHQQNKIKDLQKEQKTLQVKCQHYKKKR----TEQEETIA 173
L R + I++L++E++ L+++ + + +R TE E A
Sbjct: 1144 KTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKA 1203
Query: 174 SLQMEVCRLKKEEEDR 189
L + +L+ E+ +R
Sbjct: 1204 QLNETLTKLRTEQNER 1219
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 62.8 bits (151), Expect = 9e-10
Identities = 67/304 (22%), Positives = 144/304 (47%), Gaps = 48/304 (15%)
Query: 85 QELIETNQQLRNELQLEQSRAAN--------------------QEQ---RANDLEQIMES 121
+EL E N +L+ +LQL +S + Q+Q A+ L + ++S
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 276
Query: 122 VKSKI-GELEDESLSRACHQQNKIKDLQKEQK--TLQVKCQHYKKKRTEQEETIASLQME 178
V +K+ ++E+ L +QQ + K ++E+K + K Q ++K EQEE I + +
Sbjct: 277 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK 336
Query: 179 VCRLKK---EEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIR----KIHTQR 231
+ R ++ E+E+++ Q + +++ R+L ++ E KIR K+H Q
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEEKM------RRLEEMMWEKEEKIRELEEKMHEQE 390
Query: 232 QYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDA------LSSEKLNLQK 285
+ +E E + +EE R + + + + +++E + KI EK++ Q+
Sbjct: 391 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE 450
Query: 286 DL---ETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQA 342
+ E R Q E+ ++++++ E+ ++ K+ E +K E+ + E ++Q++
Sbjct: 451 KIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEK 510
Query: 343 LIDQ 346
+ +Q
Sbjct: 511 IREQ 514
Score = 56.2 bits (134), Expect = 8e-08
Identities = 68/358 (18%), Positives = 164/358 (45%), Gaps = 63/358 (17%)
Query: 17 RLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRM-RQNLKLLVE 75
+L+ +QQ +AE + + L K + V+ +L + + ++Q ++M RQ K+
Sbjct: 255 KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL--NQQQEEKMWRQEEKIQEW 312
Query: 76 ETSCQQN------MIQELIETNQQLRNELQL----------EQSRAANQEQRANDLEQIM 119
E Q+ +++ E +++R + ++ ++ +E++ LE++M
Sbjct: 313 EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMM 372
Query: 120 ESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEV 179
+ KI ELE++ H+Q KI++ Q+E++ + K + ++KR EQE + + ++
Sbjct: 373 WEKEEKIRELEEK-----MHEQEKIRE-QEEKRQEEEKIRE-QEKRQEQEAKMWRQEEKI 425
Query: 180 CRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQ 239
+E+E++I Q + + KIH Q + +E+E +
Sbjct: 426 ----REQEEKIREQEKKM-----------------------WRQEEKIHEQEKIREEEKR 458
Query: 240 SEEENDYRNLDASPTYKGL-----LMSLQNQLKESKSKI----DALSSEKLNLQKDLETR 290
E+E +R + + + M Q ++++ + K+ + + ++ +++ E
Sbjct: 459 QEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKM 518
Query: 291 PTQHE-LRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQR 347
Q E +R ++++++ E+ +++ ++ + K E EK E K +Q+ I ++
Sbjct: 519 WRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQ 576
Score = 43.5 bits (101), Expect = 6e-04
Identities = 30/136 (22%), Positives = 70/136 (51%), Gaps = 11/136 (8%)
Query: 60 KQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIM 119
KQ + RQ E+ Q+ I+E E + +++ ++ + QE++ + E++M
Sbjct: 492 KQEEKVWRQE-----EKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMM 546
Query: 120 ESVKSKIGELED--ESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQM 177
+ + K+GE E+ + + Q+ KI++ +++ + + K + ++K EQEE I +
Sbjct: 547 QEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQE- 605
Query: 178 EVCRLKKEEEDRIVTQ 193
+ +E+E+++ Q
Sbjct: 606 ---EMMQEQEEKMWEQ 618
Score = 39.3 bits (90), Expect = 0.010
Identities = 31/139 (22%), Positives = 68/139 (48%), Gaps = 20/139 (14%)
Query: 60 KQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIM 119
++ +++R+ + + E Q+ M+QE E + ++Q EQ + QE++ + E+ +
Sbjct: 526 REQEEKIREQEEKIRE----QEEMMQEQEEKMGEQEEKMQ-EQEKMRRQEEKIREQEEKI 580
Query: 120 ESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEV 179
K KI E E+ + Q+ KI++ ++ + + K ++K EQEE + + ++
Sbjct: 581 REQKEKIREQEE----KIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKM 636
Query: 180 -----------CRLKKEEE 187
RL+++EE
Sbjct: 637 RRQEEKMWEQEVRLRQQEE 655
Score = 38.9 bits (89), Expect = 0.014
Identities = 20/102 (19%), Positives = 55/102 (53%), Gaps = 4/102 (3%)
Query: 75 EETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESL 134
E+ Q+ I+E E ++ + +++ ++ + QE++ + E++M+ + K+ E E+
Sbjct: 564 EKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEE--- 620
Query: 135 SRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQ 176
+ C Q+ K+++ +++ + + K + + +QEE + Q
Sbjct: 621 -KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 661
>gi|58535453 CDK5 regulatory subunit associated protein 2 isoform b
[Homo sapiens]
Length = 1814
Score = 62.8 bits (151), Expect = 9e-10
Identities = 102/476 (21%), Positives = 202/476 (42%), Gaps = 84/476 (17%)
Query: 60 KQSSQRMRQNLKLLVEETSCQQNMIQELI---ETNQQLRNELQLEQSRAANQEQRANDL- 115
+Q + + + LL ++ + Q +++ ET + LR L+LE + ++ DL
Sbjct: 154 QQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALR--LRLESKLSEMKKMHEGDLA 211
Query: 116 ------------EQIMESVKSK---IGELEDESLSRACHQQN----KIKDL------QKE 150
E++ S+KSK I L++E AC +N +++ L +KE
Sbjct: 212 MALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKE 271
Query: 151 QKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPH-TVL 209
++T + +H +K+R EE I +L+ ++ +E+E I T+ + K + T+
Sbjct: 272 RETEAAQMEH-QKERNSFEERIQALEEDL----REKEREIATEKKNSLKRDKAIQGLTMA 326
Query: 210 DRQLLCLIDYYESKIRKIHT------QRQYKEDESQSEEENDYRN-------LDASPTYK 256
+ ++ S+I K+ + K + + DY L A+ +
Sbjct: 327 LKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQ 386
Query: 257 GLLMSLQNQ-----LKESKSKIDALSSEKLNLQKDLET------------RPTQHELRLY 299
L S +N +K+ ++ L E+ L+KDLE R ++E+
Sbjct: 387 NLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKL 446
Query: 300 KQQVKKLEKALKKNVKL-----------QELINHKKAEDTEKKDEP-SKYNQQQALIDQR 347
+ +V + EKA++ K QE + E T +KD K+N++ + Q+
Sbjct: 447 RNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQ 506
Query: 348 YFQVLCSINSIIHNPR--APVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTS 405
++ + + + + +Q G F+K+ Q +E L+ V++ D T
Sbjct: 507 NCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTH 566
Query: 406 L-KDLYKS--LKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDS 458
L K L +S + L AEL L+KQ E + + ++L ++ + E+ +E++S
Sbjct: 567 LVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEES 622
>gi|58535451 CDK5 regulatory subunit associated protein 2 isoform a
[Homo sapiens]
Length = 1893
Score = 62.8 bits (151), Expect = 9e-10
Identities = 102/476 (21%), Positives = 202/476 (42%), Gaps = 84/476 (17%)
Query: 60 KQSSQRMRQNLKLLVEETSCQQNMIQELI---ETNQQLRNELQLEQSRAANQEQRANDL- 115
+Q + + + LL ++ + Q +++ ET + LR L+LE + ++ DL
Sbjct: 154 QQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALR--LRLESKLSEMKKMHEGDLA 211
Query: 116 ------------EQIMESVKSK---IGELEDESLSRACHQQN----KIKDL------QKE 150
E++ S+KSK I L++E AC +N +++ L +KE
Sbjct: 212 MALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKE 271
Query: 151 QKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPH-TVL 209
++T + +H +K+R EE I +L+ ++ +E+E I T+ + K + T+
Sbjct: 272 RETEAAQMEH-QKERNSFEERIQALEEDL----REKEREIATEKKNSLKRDKAIQGLTMA 326
Query: 210 DRQLLCLIDYYESKIRKIHT------QRQYKEDESQSEEENDYRN-------LDASPTYK 256
+ ++ S+I K+ + K + + DY L A+ +
Sbjct: 327 LKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQ 386
Query: 257 GLLMSLQNQ-----LKESKSKIDALSSEKLNLQKDLET------------RPTQHELRLY 299
L S +N +K+ ++ L E+ L+KDLE R ++E+
Sbjct: 387 NLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKL 446
Query: 300 KQQVKKLEKALKKNVKL-----------QELINHKKAEDTEKKDEP-SKYNQQQALIDQR 347
+ +V + EKA++ K QE + E T +KD K+N++ + Q+
Sbjct: 447 RNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQ 506
Query: 348 YFQVLCSINSIIHNPR--APVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTS 405
++ + + + + +Q G F+K+ Q +E L+ V++ D T
Sbjct: 507 NCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTH 566
Query: 406 L-KDLYKS--LKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDS 458
L K L +S + L AEL L+KQ E + + ++L ++ + E+ +E++S
Sbjct: 567 LVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEES 622
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 62.8 bits (151), Expect = 9e-10
Identities = 107/464 (23%), Positives = 195/464 (42%), Gaps = 91/464 (19%)
Query: 52 LKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQ------------ 99
L++ I+ +KQS Q + K L++E + + I+ L E +++ L+
Sbjct: 510 LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS 569
Query: 100 LEQSRAANQEQRANDLEQ----IMESVK---SKIGELEDESLS-------------RACH 139
L Q + E R D+E+ + ES+K SK+ ++E E RA
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629
Query: 140 QQNKIKDLQKEQKTLQVKCQHYK---KKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRV 196
+N++ L+KE + LQ K + K +K E+ + L+ E +LKK + +N
Sbjct: 630 LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDS---FKNLT 686
Query: 197 FAYLCKRVPHTVLDRQLLCLIDYYES----KIRKIHTQRQYKEDESQSEE-ENDYRNLDA 251
F ++ LD + L L ES ++ Q + KE ES+ E+ + L A
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 252 S--------PTYKGLLMS---LQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYK 300
S +Y+GL + LQ L+ S KI L SE +L+ +E + Q L K
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE--MENQTLQKNLEELK 804
Query: 301 QQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIH 360
K+LE+ K+N L++ + + + + + E + QQ + D + I
Sbjct: 805 ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI----- 859
Query: 361 NPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTL---- 416
G ++ NK L ++ G ++ + LK+L K K L
Sbjct: 860 -------------GNLEKENKTLSKEIG---------IYKESCVRLKELEKENKELVKRA 897
Query: 417 SAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVE----NKEK 456
+ ++ + L++ +E +K + + ++ + E+E NKE+
Sbjct: 898 TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER 941
Score = 56.2 bits (134), Expect = 8e-08
Identities = 78/342 (22%), Positives = 152/342 (44%), Gaps = 47/342 (13%)
Query: 15 SDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKR--------TDLKDLIIFDKQSSQRM 66
S++L T++ + E + H L+ + L K TD + + + +
Sbjct: 913 SEKLKTQQMNNDLE-------KLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTL 965
Query: 67 RQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMES--VKS 124
+++L++ E+ + + ++E NQQLR EL+ + +QR ++ + S +
Sbjct: 966 KKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG 1025
Query: 125 KIGELEDESLSRACHQQNKIKD----LQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVC 180
+ + E ES + K+KD +++ TLQ + Q K + + E +LQ ++
Sbjct: 1026 EDNKWERES-QETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQIL 1084
Query: 181 RLKK------EEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYK 234
L++ E+ + TQN +V ++ L+ Q L++ + I
Sbjct: 1085 ALQRQTVSLQEQNTTLQTQNAKL-----QVENSTLNSQSTSLMNQNAQLL--IQQSSLEN 1137
Query: 235 EDESQSEEENDYRNLDAS--PTYKGLLMSLQNQLKESKSKID---ALSSEKLNLQ---KD 286
E+ES +E D ++L S ++ L + + Q E +S I L S NL+ +D
Sbjct: 1138 ENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRD 1197
Query: 287 LETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDT 328
LE R ++L K Q++ LEK LK V+ ++++ K +T
Sbjct: 1198 LEDR--YNQLLKQKGQLEDLEKMLK--VEQEKMLLENKNHET 1235
Score = 54.3 bits (129), Expect = 3e-07
Identities = 95/428 (22%), Positives = 182/428 (42%), Gaps = 57/428 (13%)
Query: 59 DKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQI 118
+ QS + + L+ V+ + I ++ + NQ+L ++++ ++ ++Q + + +
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 119 MESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQME 178
+ + + +LE + + + +IK L++E + L +T++SL+
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL--------------NQTVSSLRQ- 572
Query: 179 VCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDES 238
R + E R+ + L + + T L I++ + +I+K YKE
Sbjct: 573 --RSQISAEARVKDIEKENKILHESIKET---SSKLSKIEFEKRQIKK--ELEHYKEKGE 625
Query: 239 QSEE-ENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELR 297
++EE EN+ +L+ LL LK + KI+AL E L++ E R + L
Sbjct: 626 RAEELENELHHLEKE---NELLQKKITNLKITCEKIEALEQENSELER--ENRKLKKTLD 680
Query: 298 LYKQ---QVKKLEK----------ALKKNVKLQELINHKKAE-DTEKKDEPSKYNQQQAL 343
+K Q++ LEK L++NV+ + + K A+ E K+ S+ Q +
Sbjct: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG 740
Query: 344 ID------QRYFQVLCSINSI-IHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEH--LVP 394
++ ++ ++ S + I N R + K +Q +L QD E+ L
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNK-KIQQLESEL-QDLEMENQTLQK 798
Query: 395 VIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEE---- 450
+E L+ L K K+L E KKQ E E ++ I DT LEE
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858
Query: 451 VENKEKDS 458
+ N EK++
Sbjct: 859 IGNLEKEN 866
Score = 53.1 bits (126), Expect = 7e-07
Identities = 74/332 (22%), Positives = 146/332 (43%), Gaps = 44/332 (13%)
Query: 21 EKQQEEAEWESINVLLMMHGLKPLSL-VKRTDLKDLII-FDKQSSQRMRQNLKLLVEETS 78
EK+ + + E++ + + LK S+ + + L++ + +K+ ++ + LK ++T
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Query: 79 CQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRAC 138
+ Q L NQ+L+ L+ + E DLE ++++ + EL+ S
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISS----- 807
Query: 139 HQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFA 198
+++ L+KE K+L+ + +K + + E+ L R + E +D + +N V
Sbjct: 808 ---KRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL-----RQQAEIKDTTLEENNVKI 859
Query: 199 YLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGL 258
++ T L +++ Y ES +R KE E +++E +D
Sbjct: 860 GNLEKENKT-LSKEIGI---YKESCVR-------LKELEKENKELVKRATIDIK-----T 903
Query: 259 LMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRL----------YKQQVKKLEK 308
L++L+ L K K ++++ L +LE E L YK KLE
Sbjct: 904 LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLES 963
Query: 309 ALKKNVKLQELINHKKAEDTEKKDEPSKYNQQ 340
LKK+++++E K A + +E + YNQQ
Sbjct: 964 TLKKSLEIKE---EKIAALEARLEESTNYNQQ 992
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 62.8 bits (151), Expect = 9e-10
Identities = 107/464 (23%), Positives = 195/464 (42%), Gaps = 91/464 (19%)
Query: 52 LKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQ------------ 99
L++ I+ +KQS Q + K L++E + + I+ L E +++ L+
Sbjct: 510 LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS 569
Query: 100 LEQSRAANQEQRANDLEQ----IMESVK---SKIGELEDESLS-------------RACH 139
L Q + E R D+E+ + ES+K SK+ ++E E RA
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629
Query: 140 QQNKIKDLQKEQKTLQVKCQHYK---KKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRV 196
+N++ L+KE + LQ K + K +K E+ + L+ E +LKK + +N
Sbjct: 630 LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDS---FKNLT 686
Query: 197 FAYLCKRVPHTVLDRQLLCLIDYYES----KIRKIHTQRQYKEDESQSEE-ENDYRNLDA 251
F ++ LD + L L ES ++ Q + KE ES+ E+ + L A
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 252 S--------PTYKGLLMS---LQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYK 300
S +Y+GL + LQ L+ S KI L SE +L+ +E + Q L K
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE--MENQTLQKNLEELK 804
Query: 301 QQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIH 360
K+LE+ K+N L++ + + + + + E + QQ + D + I
Sbjct: 805 ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI----- 859
Query: 361 NPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTL---- 416
G ++ NK L ++ G ++ + LK+L K K L
Sbjct: 860 -------------GNLEKENKTLSKEIG---------IYKESCVRLKELEKENKELVKRA 897
Query: 417 SAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVE----NKEK 456
+ ++ + L++ +E +K + + ++ + E+E NKE+
Sbjct: 898 TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER 941
Score = 54.7 bits (130), Expect = 2e-07
Identities = 74/331 (22%), Positives = 146/331 (44%), Gaps = 43/331 (12%)
Query: 21 EKQQEEAEWESINVLLMMHGLKPLSL-VKRTDLKDLII-FDKQSSQRMRQNLKLLVEETS 78
EK+ + + E++ + + LK S+ + + L++ + +K+ ++ + LK ++T
Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Query: 79 CQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRAC 138
+ Q L NQ+L+ L+ + E DLE ++++ + EL+ S
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISS----- 807
Query: 139 HQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFA 198
+++ L+KE K+L+ + +K + + E+ L R + E +D + +N V
Sbjct: 808 ---KRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL-----RQQAEIKDTTLEENNVKI 859
Query: 199 YLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGL 258
++ T L +++ Y ES +R KE E +++E +D
Sbjct: 860 GNLEKENKT-LSKEIGI---YKESCVR-------LKELEKENKELVKRATIDIK-----T 903
Query: 259 LMSLQNQLKESKSKIDALSS---------EKLNLQKDLETRPTQHELRLYKQQVKKLEKA 309
L++L+ L K K +++ EK+ L K+ Q YK KLE
Sbjct: 904 LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLEST 963
Query: 310 LKKNVKLQELINHKKAEDTEKKDEPSKYNQQ 340
LKK+++++E K A + +E + YNQQ
Sbjct: 964 LKKSLEIKE---EKIAALEARLEESTNYNQQ 991
Score = 54.3 bits (129), Expect = 3e-07
Identities = 95/428 (22%), Positives = 182/428 (42%), Gaps = 57/428 (13%)
Query: 59 DKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQI 118
+ QS + + L+ V+ + I ++ + NQ+L ++++ ++ ++Q + + +
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 119 MESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQME 178
+ + + +LE + + + +IK L++E + L +T++SL+
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL--------------NQTVSSLRQ- 572
Query: 179 VCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDES 238
R + E R+ + L + + T L I++ + +I+K YKE
Sbjct: 573 --RSQISAEARVKDIEKENKILHESIKET---SSKLSKIEFEKRQIKK--ELEHYKEKGE 625
Query: 239 QSEE-ENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELR 297
++EE EN+ +L+ LL LK + KI+AL E L++ E R + L
Sbjct: 626 RAEELENELHHLEKE---NELLQKKITNLKITCEKIEALEQENSELER--ENRKLKKTLD 680
Query: 298 LYKQ---QVKKLEK----------ALKKNVKLQELINHKKAE-DTEKKDEPSKYNQQQAL 343
+K Q++ LEK L++NV+ + + K A+ E K+ S+ Q +
Sbjct: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG 740
Query: 344 ID------QRYFQVLCSINSI-IHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEH--LVP 394
++ ++ ++ S + I N R + K +Q +L QD E+ L
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNK-KIQQLESEL-QDLEMENQTLQK 798
Query: 395 VIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEE---- 450
+E L+ L K K+L E KKQ E E ++ I DT LEE
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858
Query: 451 VENKEKDS 458
+ N EK++
Sbjct: 859 IGNLEKEN 866
Score = 51.6 bits (122), Expect = 2e-06
Identities = 95/443 (21%), Positives = 175/443 (39%), Gaps = 101/443 (22%)
Query: 15 SDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKD-------LIIFDKQSSQRMR 67
S++L T++ + E + H L+ + L K L D + + + ++
Sbjct: 913 SEKLKTQQMNNDLE-------KLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLK 965
Query: 68 QNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMES--VKSK 125
++L++ E+ + + ++E NQQLR EL+ + +QR ++ + S + +
Sbjct: 966 KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1025
Query: 126 IGELEDESLSRACHQQNKIKD----LQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCR 181
+ E ES + K+KD +++ TLQ + Q K + + E +LQ ++
Sbjct: 1026 DNKWERES-QETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1084
Query: 182 LKK------EEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKE 235
L++ E+ + TQN +V ++ L+ Q L++ + I E
Sbjct: 1085 LQRQTVSLQEQNTTLQTQNAKL-----QVENSTLNSQSTSLMNQNAQLL--IQQSSLENE 1137
Query: 236 DESQSEEENDYRNLDAS--PTYKGLLMSLQNQLKESKSKID---ALSSEKLNLQ---KDL 287
+ES +E D ++L S ++ L + + Q E +S I L S NL+ +DL
Sbjct: 1138 NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDL 1197
Query: 288 ETRPTQHELRLYKQQVKKLEKALK------------------------------------ 311
E R Q L K Q++ LEK LK
Sbjct: 1198 EDRYNQ--LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1255
Query: 312 ----------KNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHN 361
+ L+ L+N+ K E T + E SK +Q +D I S N
Sbjct: 1256 LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLD---------ITSTKLN 1306
Query: 362 PRAPVIIYKQTKGGVQNFNKDLV 384
+ ++ Q KG ++ N+ L+
Sbjct: 1307 NQCELL--SQLKGNLEEENRHLL 1327
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 62.0 bits (149), Expect = 1e-09
Identities = 116/511 (22%), Positives = 218/511 (42%), Gaps = 89/511 (17%)
Query: 41 LKPLSLVKRTD----LKD---LIIFDKQSS-----QRMRQNLKLLVEETSCQQNMIQELI 88
+KPL V R + KD L + +KQ+ + M + + L+EE +N++ E +
Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEE----KNILAEQL 896
Query: 89 ETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQ 148
+ +L E + ++R A ++Q +LE+I+ ++S++ E E+ +N+I LQ
Sbjct: 897 QAETELFAEAEEMRARLAAKKQ---ELEEILHDLESRVEEEEE---------RNQI--LQ 942
Query: 149 KEQKTLQVKCQHYKKKRTEQEETIASLQME----VCRLKKEEEDRIVTQNRVFAYLCKRV 204
E+K +Q Q +++ E+E LQ+E ++KK EE+ ++ +++ ++ ++
Sbjct: 943 NEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK- 1001
Query: 205 PHTVLDRQLLCLIDYYE--------SKIRKIH-------TQRQYKEDESQSEEENDYRNL 249
+ DR C E +KIR +R KE++++ E E R L
Sbjct: 1002 -KLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060
Query: 250 DASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKA 309
D T LQ+Q+ E +++ID L KL L K E Q L + A
Sbjct: 1061 DGETT------DLQDQIAELQAQIDEL---KLQLAKKEE--ELQGALARGDDETLHKNNA 1109
Query: 310 LKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIY 369
LK +LQ I + + +K +K +Q+ + + + + + A +
Sbjct: 1110 LKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELR 1169
Query: 370 KQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQ 429
+ + V K L ++ H + +M T+L++L + L+ NL+K
Sbjct: 1170 TKREQEVAELKKALEEETK-NHEAQIQDMRQRHATALEELSEQLEQAKRFKA---NLEK- 1224
Query: 430 DENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFD--VPSLNGVYP 487
+G+ E +NKE + Q ++A H +K D V L+
Sbjct: 1225 -NKQGL--------------ETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVS 1269
Query: 488 RMNEVYTRLGEMNNAVRNLQELLELDSSSSL 518
+ + L E + ++N ELD+ S+L
Sbjct: 1270 EGDRLRVELAEKASKLQN-----ELDNVSTL 1295
Score = 56.2 bits (134), Expect = 8e-08
Identities = 81/313 (25%), Positives = 137/313 (43%), Gaps = 47/313 (15%)
Query: 64 QRMRQNLKLLVEETSCQQNMIQELIETNQQLRNEL--QLEQSRA--ANQEQRANDLEQIM 119
Q + + K L EET + IQ++ + + EL QLEQ++ AN E+ LE
Sbjct: 1174 QEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDN 1233
Query: 120 ESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQME- 178
+ + ++ L+ ++K K L + + L K + R E E + LQ E
Sbjct: 1234 KELACEVKVLQQVK----AESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL 1289
Query: 179 --VCRLKKEEEDRIVTQNRVFAYLCKRVPHTVL-----DRQLLCLIDYYESKIRKIHTQR 231
V L +E E + + + A L ++ T RQ L L S+IR++ ++
Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNL----SSRIRQLEEEK 1345
Query: 232 QYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKID-------ALSSEKLNLQ 284
+ E Q EEE +NL+ +++LQ+QL ++K K+D +L K L
Sbjct: 1346 NSLQ-EQQEEEEEARKNLEKQ------VLALQSQLADTKKKVDDDLGTIESLEEAKKKLL 1398
Query: 285 KDLETRPTQHELRLYKQQVKKLEKALKKNVKLQEL------INHKKAEDTEKKDEPSKYN 338
KD E + E + KLEK KN QEL ++H++ + + + K++
Sbjct: 1399 KDAEALSQRLEEKALAYD--KLEKT--KNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD 1454
Query: 339 Q---QQALIDQRY 348
Q ++ I RY
Sbjct: 1455 QLLAEEKSISARY 1467
Score = 40.4 bits (93), Expect = 0.005
Identities = 74/372 (19%), Positives = 157/372 (42%), Gaps = 47/372 (12%)
Query: 16 DRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQS------SQRMRQN 69
D+L K + + E + + V L +L K+ D ++ +++S +R R
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475
Query: 70 LKLLVEETSCQQ--NMIQELIET-------NQQLRNELQLEQS-------RAANQEQRAN 113
+ +ET ++E +E N+QLR +++ S E+
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535
Query: 114 DLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQ-EETI 172
LEQ +E +++++ ELEDE + + K++ L+ + ++ + + + R EQ EE
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQAT---EDAKLR-LEVNMQAMKAQFERDLQTRDEQNEEKK 1591
Query: 173 ASLQMEVCRLKKEEEDRIVTQNRVFAYLCKR---VPHTVLDRQLLCLIDYYESKIRKIH- 228
L +V L+ E ED + R A K+ + L+ Q+ + I+++
Sbjct: 1592 RLLIKQVRELEAELEDE--RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK 1649
Query: 229 TQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLE 288
Q Q K+ + + EE R+ + Q KES+ K+ +L +E L LQ++L
Sbjct: 1650 LQAQMKDYQRELEEARASRD------------EIFAQSKESEKKLKSLEAEILQLQEELA 1697
Query: 289 T--RPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQ 346
+ R +H + + ++ + L + +A + ++E + L++
Sbjct: 1698 SSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757
Query: 347 RYFQVLCSINSI 358
R+ + ++++
Sbjct: 1758 RFRKTTLQVDTL 1769
Score = 39.3 bits (90), Expect = 0.010
Identities = 48/245 (19%), Positives = 97/245 (39%), Gaps = 42/245 (17%)
Query: 83 MIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQN 142
+I+++ E +L +E + A++++ DL+ + +++ + DE + + Q
Sbjct: 1594 LIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAA-NKARDEVIKQLRKLQA 1652
Query: 143 KIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCK 202
++KD Q+E + + + E E+ + SL+ E+ +L++E
Sbjct: 1653 QMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEE----------------- 1695
Query: 203 RVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSL 262
+ E R +R DE + LD + + L
Sbjct: 1696 --------------LASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQL 1741
Query: 263 QNQLKESKSKIDALSS--EKLNLQKD------LETRPTQHELRLYKQQVKKLEKALKKNV 314
+ +L+E +S ++ L+ K LQ D R + +QQ+++ K LK
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK--A 1799
Query: 315 KLQEL 319
KLQEL
Sbjct: 1800 KLQEL 1804
Score = 33.1 bits (74), Expect = 0.75
Identities = 31/136 (22%), Positives = 70/136 (51%), Gaps = 11/136 (8%)
Query: 58 FDKQSSQRMRQNLKLLVEETSCQQ--NMIQELIETNQQLRNELQLEQSRAANQEQRANDL 115
F K + Q N +L E ++ Q+ N Q+L N++L+ +LQ E A + +A
Sbjct: 1759 FRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ-ELEGAVKSKFKAT-- 1815
Query: 116 EQIMESVKSKIGELEDESLSRACHQ--QNK-IKDLQKEQKTLQVKCQHYKKKRTEQEETI 172
+ ++++KIG+LE++ A + NK ++ +K+ K + ++ + ++ + +E +
Sbjct: 1816 ---ISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQM 1872
Query: 173 ASLQMEVCRLKKEEED 188
+ +LK++ E+
Sbjct: 1873 EKANARMKQLKRQLEE 1888
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 61.6 bits (148), Expect = 2e-09
Identities = 118/513 (23%), Positives = 216/513 (42%), Gaps = 81/513 (15%)
Query: 69 NLKLLVEETSCQQNMIQE-LIE---TNQQLRNELQLEQSRAANQEQRANDLEQIMESVKS 124
+LK+ + + Q +IQE L+E + +L +E+ + S+ E++ + S+ +
Sbjct: 659 DLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAA 718
Query: 125 KIGELEDESLSRACHQQNKIKDLQKE------------QKTLQVKCQHYKKKRTEQEETI 172
K ELE E + + KI+ L+ +K ++ + +K+ + E
Sbjct: 719 KNAELEQELMEK----NEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLE 774
Query: 173 ASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQ 232
A L+ + + K++E+ + Q + +CK+ LDR L E K +
Sbjct: 775 AQLEKKDQQFKEQEKTMSMLQQDI---ICKQHHLESLDR--LLTESKGEMKKENMKKDEA 829
Query: 233 YKEDESQ-SEEENDYRNLDAS-PTYKGLLMSLQNQLKESKSKIDAL----SSEKLNLQKD 286
K ++Q SEE R LD++ K L+ NQL+ +K K + S E LQK+
Sbjct: 830 LKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE 889
Query: 287 LETRPTQHELRLYKQQVKKLEKALKKNVKL--QELINHKKAEDTEKKDEPSKYNQQQALI 344
L+ + H L+ +Q L+ L++ ++ QE I + + EDT+ K E +Q L
Sbjct: 890 LKIK--NHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQ 947
Query: 345 DQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMW--ADQ 402
QR A + + K DL + VIE+ A Q
Sbjct: 948 KQR-------------ESSAEKLRKMEEKCESAAHEADLKRQ-------KVIELTGTARQ 987
Query: 403 LTSLKDLYKS-LKTLSAELVPWLNLKKQDENEGIKVEDLLFIVD---TMLEEVENKEKDS 458
+ D YK L + E+ ++LK+ EN+ + + L I+D T LE+ N K+
Sbjct: 988 VKIEMDQYKEELSKMEKEI---MHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKEL 1044
Query: 459 NMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRLGEMNNAVRNLQELLELDSSSSL 518
T + QK + + E+ GE+ + +R LQEL ++ + L
Sbjct: 1045 EKLQHSTETELTEALQKREVLET---------ELQNAHGELKSTLRQLQELRDVLQKAQL 1095
Query: 519 CV--LVSTVGKL------CRLINEDVNEQVMQV 543
+ +T+ L C++ ED ++++++
Sbjct: 1096 SLEEKYTTIKDLTAELRECKMEIEDKKQELLEM 1128
Score = 54.3 bits (129), Expect = 3e-07
Identities = 54/271 (19%), Positives = 121/271 (44%), Gaps = 24/271 (8%)
Query: 58 FDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQ 117
F+KQ ++ + + L +E + + +QE E N L++ LQ +Q + R +LE
Sbjct: 872 FEKQLKKKSEE-VYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELED 930
Query: 118 IMESVKSKIGELEDESLSRACHQQNKIKDLQ------------KEQKTLQV--KCQHYKK 163
++ ++ +LE E + K++ ++ K QK +++ + K
Sbjct: 931 TQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKI 990
Query: 164 KRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESK 223
+ + +E ++ ++ E+ LK++ E++ + +++ L + + ++ +
Sbjct: 991 EMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHS 1050
Query: 224 IRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNL 283
T+ K + ++E +N + L K L LQ +L++ K EK
Sbjct: 1051 TETELTEALQKREVLETELQNAHGEL------KSTLRQLQ-ELRDVLQKAQLSLEEKYTT 1103
Query: 284 QKDL--ETRPTQHELRLYKQQVKKLEKALKK 312
KDL E R + E+ KQ++ ++++ALK+
Sbjct: 1104 IKDLTAELRECKMEIEDKKQELLEMDQALKE 1134
Score = 48.5 bits (114), Expect = 2e-05
Identities = 69/320 (21%), Positives = 142/320 (44%), Gaps = 30/320 (9%)
Query: 39 HGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLK-LLVEETSCQ---QNMIQELIETNQQL 94
HG +L + +L+D++ + S + +K L E C+ ++ QEL+E +Q L
Sbjct: 1073 HGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQAL 1132
Query: 95 RNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQN---KIKDLQKEQ 151
+ R +QRA + + +++ GE+E + + + ++K+ K+
Sbjct: 1133 KE-------RNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQI 1185
Query: 152 KTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDR 211
++L K Q+ K++ E+E + + E+ +LKKE E TQ R+ + +V+
Sbjct: 1186 ESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIER---TQQRM------KEMESVMKE 1236
Query: 212 QLLCLIDYYESKI---RKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKE 268
Q + Y+ I +++ R+ ++ E ++ + A + L L++ +
Sbjct: 1237 QEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQL 1296
Query: 269 SKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALK--KNVKLQELINHKKAE 326
SK K DA + + R E R+ + ++KKL ++ K E+I+H++
Sbjct: 1297 SKEK-DAHGNHLAEELGASKVREAHLEARM-QAEIKKLSAEVESLKEAYHMEMISHQENH 1354
Query: 327 DTEKKDEPSKYNQQQALIDQ 346
K S+ + Q L +Q
Sbjct: 1355 AKWKISADSQKSSVQQLNEQ 1374
Score = 45.8 bits (107), Expect = 1e-04
Identities = 51/294 (17%), Positives = 130/294 (44%), Gaps = 32/294 (10%)
Query: 25 EEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMI 84
E A+ ++ +V ++ + ++L +D ++ +++ ++ Q+ K+++E+ Q
Sbjct: 277 ESAQQQAASVPILEEQI--INLEAEVSAQDKVL--REAENKLEQSQKMVIEKEQSLQESK 332
Query: 85 QELIETNQQLRNELQLEQSRAANQEQR-----ANDLEQIMESVKSKIGELEDESLSRACH 139
+E I+ L Q +Q + A +++ A +L + + K K+ E ++ +
Sbjct: 333 EECIKLKVDLLE--QTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEI 390
Query: 140 QQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAY 199
+ + + +KE K LQ +C YK + +E + L KEE + + R+ A
Sbjct: 391 LERNLTNCEKENKRLQERCGLYKSELEILKEKLRQL--------KEENNNGKEKLRIMA- 441
Query: 200 LCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLL 259
V + +++ + I K+ ++ + K++ + + + ++ + K +
Sbjct: 442 --------VKNSEVMAQLTESRQSILKLESELENKDEILRDK----FSLMNENRELKVRV 489
Query: 260 MSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKN 313
+ +L + +I++ E +L+K + P + EL +K + K + + N
Sbjct: 490 AAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSN 543
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 61.2 bits (147), Expect = 3e-09
Identities = 121/569 (21%), Positives = 246/569 (43%), Gaps = 115/569 (20%)
Query: 51 DLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNE--------LQLEQ 102
+ DL+ + ++ R+R++ + + S +++ +EL E N+ L N QL+
Sbjct: 549 EANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQA 608
Query: 103 SRAANQEQRANDLEQIMESVKSKIGELEDE------SLSRACHQQNKIKDL----QKEQK 152
A + R +D E I + ++++I L++E +L + ++ + +D+ +KE+
Sbjct: 609 ILEAERRDRGHDSEMIGD-LQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKN 667
Query: 153 TLQVKCQHYKK---KRTEQE---------------------ETIASLQMEVCRLKKEEED 188
L++ + K +R EQE +++A +ME +LK+E E
Sbjct: 668 NLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEK-KLKEEREA 726
Query: 189 RIVTQNRVFAYLCKRVPHTVLDRQLLCL-IDYYES--KIRKIHTQRQYKEDE-----SQS 240
R +NRV +++Q L +D +S K+ + ++ EDE Q
Sbjct: 727 REKAENRV----------VQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQL 776
Query: 241 EEENDYRNL--DASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDL----------- 287
E+E++ R L + T +L+ K+ K +I+ L K L+ +L
Sbjct: 777 EQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNE 836
Query: 288 -ETRPTQHELR-------LYKQQVKKLEKALKKN-----VKLQELINHKKAEDTEKKDEP 334
+ R Q +L LYK QVK+L++ +++ K+QEL N K+ T+
Sbjct: 837 GQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAE 896
Query: 335 SKYNQQQ---ALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEH 391
+K +Q L++++YF++ R + T ++ N L +D E
Sbjct: 897 TKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKD--IEI 954
Query: 392 LVPVIEMWADQLTSLKDLYK-----SLKTLSAELVPWLNLKKQDENEGI-KVEDLL---- 441
L E +++ ++ YK + L A +N ++ + + + K+ +++
Sbjct: 955 LRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKD 1014
Query: 442 FIVD---TMLEEVENKEKDS-------NMPHFQTLQAIVSHFQKLFDVPS-LNGVYPRMN 490
F +D +++ KEK++ N + Q +V H ++L D+ + L N
Sbjct: 1015 FKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRN 1074
Query: 491 EVYTRLGEMNNAVRNLQ-ELLELDSSSSL 518
E+ +L + + L+ +LL+L S+S+
Sbjct: 1075 ELQMQLASKESDIEQLRAKLLDLSDSTSV 1103
Score = 55.8 bits (133), Expect = 1e-07
Identities = 65/277 (23%), Positives = 126/277 (45%), Gaps = 58/277 (20%)
Query: 76 ETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLS 135
+ S Q+++ + + + +QL NE+QL+ L++IM+ EL++E
Sbjct: 421 DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMK-------ELDEEGNQ 473
Query: 136 RACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEED-RIVTQN 194
R + ++ + ++KE+ LQ + Y++K ++ E +++ EV LK + ED + V+QN
Sbjct: 474 RR-NLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQN 532
Query: 195 RVFAYLCKRVPHTVLDRQLLCLIDYYES------KIRKIHTQ------------RQYKE- 235
A + L +QL D + ++RK HT+ R+ +E
Sbjct: 533 SQLA----NEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQER 588
Query: 236 ----DESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRP 291
+ S+S+ + DY L A + E++ + SE + DL+ R
Sbjct: 589 NRILENSKSQTDKDYYQLQA--------------ILEAERRDRGHDSEMIG---DLQARI 631
Query: 292 T--QHELRLYKQQVKKLEKALKKNVKLQELINHKKAE 326
T Q E++ K ++K+E K + Q+++NH + E
Sbjct: 632 TSLQEEVKHLKHNLEKVEGERK---EAQDMLNHSEKE 665
Score = 37.4 bits (85), Expect = 0.040
Identities = 50/258 (19%), Positives = 108/258 (41%), Gaps = 29/258 (11%)
Query: 45 SLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSR 104
S + +T +K+L ++ ++ R+NLK IQEL + L +L L +++
Sbjct: 853 STLYKTQVKEL---KEEIEEKNRENLK-----------KIQELQNEKETLATQLDLAETK 898
Query: 105 AANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKD----LQKEQKTLQVKCQH 160
A +++ LE+ + EL ES A + +I D + + ++ + +
Sbjct: 899 AESEQLARGLLEE-------QYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKD 951
Query: 161 YKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYY 220
+ R E EE ++ K E+E+ I F T+ + + L +
Sbjct: 952 IEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNI-NTERTLKTQAVNKLAEIM 1010
Query: 221 ESKIRKIHTQRQYKEDESQSEEENDYRNLDAS---PTYKGLLMSLQNQLKESKSKIDALS 277
K KI ++ +D + E+EN L+ + + +++ Q +L + ++++
Sbjct: 1011 NRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEEC 1070
Query: 278 SEKLNLQKDLETRPTQHE 295
+ + LQ L ++ + E
Sbjct: 1071 AHRNELQMQLASKESDIE 1088
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 60.5 bits (145), Expect = 4e-09
Identities = 67/308 (21%), Positives = 141/308 (45%), Gaps = 28/308 (9%)
Query: 42 KPLSLVKRTDLKD------LIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLR 95
K +S + T L D ++F+ Q + +NL+ +E ++E++E Q
Sbjct: 435 KEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTEL 494
Query: 96 NEL--QLEQSRAANQEQRANDLEQIMESVKSKIGELED--ESLSRA-------CHQQNKI 144
E ++ Q + ++Q+A+D+ ++ + +++ E + E+++R QQ +
Sbjct: 495 GESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELV 554
Query: 145 KDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRV------FA 198
+L+ K LQ K Y ++++ + L+ ++ L +E++D I F
Sbjct: 555 PELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFH 614
Query: 199 YLCKRVPHTVLD--RQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYK 256
C+R +L+ +++ I Y +K++ E+ + +++ND + K
Sbjct: 615 KKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMK 674
Query: 257 GLLMS---LQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKN 313
L L ++K + + LSSEK L +DLE +Q E + K+ + +LEK L+
Sbjct: 675 VLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLM 734
Query: 314 VKLQELIN 321
V+ Q+ +N
Sbjct: 735 VEEQDNLN 742
Score = 55.5 bits (132), Expect = 1e-07
Identities = 67/308 (21%), Positives = 144/308 (46%), Gaps = 40/308 (12%)
Query: 70 LKLLVEETSCQQNMIQ-ELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGE 128
++L E+ Q+ M + EL++ + Q + +E A+ E+ +L Q + + +KI +
Sbjct: 1129 VQLQKEKKQLQKTMQELELVKKDAQQTTLMNME---IADYERLMKELNQKLTNKNNKIED 1185
Query: 129 LEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEED 188
LE E Q+ K + LQ+E +LQ Q Y++K T+ ++ + + E+ K+ E D
Sbjct: 1186 LEQEIKI----QKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETD 1241
Query: 189 RIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRN 248
++ Q + L +Q ++ Y+ ++ +I +++ + ++ E R
Sbjct: 1242 HLILQASLKGEL------EASQQQ----VEVYKIQLAEITSEKHKIHEHLKTSAEQHQRT 1291
Query: 249 LDASPTYKGLLMSLQNQLKESKSKIDALSSE----KLNLQKDLETRP----TQHELRLYK 300
L A Y+ + +LQ + + +K++ ++SE K+ + L+ + +Q E K
Sbjct: 1292 LSA---YQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAK 1348
Query: 301 QQVKKLEKALKK-NVKLQELINHKKAEDTEKKDEPSKYN----------QQQALIDQRYF 349
Q+ + LE + + +KLQ+ N+ + +E + S+++ Q+ +
Sbjct: 1349 QEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELR 1408
Query: 350 QVLCSINS 357
+ LCSI S
Sbjct: 1409 EKLCSIQS 1416
Score = 47.0 bits (110), Expect = 5e-05
Identities = 84/382 (21%), Positives = 169/382 (44%), Gaps = 47/382 (12%)
Query: 28 EWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMR---QNLKLLVEETS--CQQN 82
++E VLL L+ + K DL+ K ++++ R QNL + VEE S C ++
Sbjct: 835 DYEQEKVLLRKE-LEEIQSEKEALQSDLLEM-KNANEKTRLENQNLLIQVEEVSQTCSKS 892
Query: 83 MIQE-----LIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRA 137
I I+ ++ L+ L+ ++ R R +L + +S+ +K ++++ LS
Sbjct: 893 EIHNEKEKCFIKEHENLKPLLEQKELR-----DRRAELILLKDSL-AKSPSVKNDPLSSV 946
Query: 138 CHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVF 197
+ KI++L+KE K + K K + ++ + S + E +K+E E ++++
Sbjct: 947 KELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLS 1006
Query: 198 AYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQ---------------RQYKEDESQ--- 239
A + + + LL YE + ++ + RQ + Q
Sbjct: 1007 ASMRDLIQGAESYKNLLL---EYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCET 1063
Query: 240 --SEEENDYRNLDASPTYKGLLMSLQNQLKESKSKID-ALSSEKLNL-QKDLETRPTQHE 295
S+ E+ ++ + LL +++ +K+ +D L +EKL QK E T +E
Sbjct: 1064 INSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123
Query: 296 LRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSI 355
L + Q++K +K L+K ++ EL+ + T E + Y + ++Q+ L +
Sbjct: 1124 LEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQK----LTNK 1179
Query: 356 NSIIHNPRAPVIIYKQTKGGVQ 377
N+ I + + I KQ + +Q
Sbjct: 1180 NNKIEDLEQEIKIQKQKQETLQ 1201
Score = 42.7 bits (99), Expect = 0.001
Identities = 112/565 (19%), Positives = 218/565 (38%), Gaps = 89/565 (15%)
Query: 25 EEAEWESINVLLMMHGLK-PLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNM 83
+E E IN + + LK L V+ +D KQ + M L+L +Q
Sbjct: 118 KELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLEL------SEQLK 171
Query: 84 IQELIETNQQLRNELQLEQSRAANQEQ---RANDLEQIMESVKSKIGELEDESLSRACHQ 140
Q E N + E ++E+ R +EQ L+ + K + +L++ + + H
Sbjct: 172 FQNNSEDNVKKLQE-EIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHY 230
Query: 141 QNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYL 200
Q I LQ+E LQ+K H +E + L ++ KE E I N + L
Sbjct: 231 QKNINSLQEE--LLQLKAIH--------QEEVKELMCQIEASAKEHEAEINKLNELKENL 280
Query: 201 CKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLM 260
K Q + E Q + E + NL + +
Sbjct: 281 VK---------------------------QCEASEKNIQKKYECELENLRKATSNANQDN 313
Query: 261 SLQNQLKESKSKIDALSSEKL-NLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQEL 319
+ + L + + ++ + +EK+ +L+ L+ +QH + K E N+KL+
Sbjct: 314 QICSILLQENTFVEQVVNEKVKHLEDTLKELESQH-------SILKDEVTYMNNLKLKLE 366
Query: 320 INHKKAEDT---EKKDEPSKYN------QQQALIDQRYFQVLCSIN-----SIIHNPRAP 365
++ + +D E++D K N ++Q + ++ L +N ++ + R
Sbjct: 367 MDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREV 426
Query: 366 VIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWLN 425
+ +Q + + N+ + D E L + E + LK+ ++L+ E + LN
Sbjct: 427 QSLKEQHQKEISELNETFLSDSEKEKLTLMFE-----IQGLKEQCENLQQEKQEAI--LN 479
Query: 426 LKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQK----LFDVPS 481
+ E I +L + +E E+ ++ + Q + + F + L V
Sbjct: 480 YESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNR 539
Query: 482 LNGVYPRMNEVYTRLGEMNNAVRNLQE-----LLELDSSSSLCVLVSTVGKLCRLINEDV 536
L G ++ + E+ N ++NLQE LL L ++ L GK+ + E+
Sbjct: 540 LQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTM--LKELEGKI-NSLTEEK 596
Query: 537 NEQVMQVLGPEDLQSIIYKLEEHEE 561
++ + ++ + +K E EE
Sbjct: 597 DDFINKLKNSHEEMDNFHKKCEREE 621
Score = 34.7 bits (78), Expect = 0.26
Identities = 77/404 (19%), Positives = 170/404 (42%), Gaps = 75/404 (18%)
Query: 84 IQELIETNQQLR---NELQ--LEQSRAANQEQRANDLEQIMESVK----------SKIGE 128
+++ I+ N +L NEL LE++ ++Q LE++M +K +++
Sbjct: 631 VEQTIQYNSELEQKVNELTGGLEET-LKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKS 689
Query: 129 LEDESLSRACHQQNKIKDL-----QKEQKTLQVKCQHYKKK---RTEQEETIASLQMEVC 180
L +E+ + ++ +DL QKE L+ +KK E+++ + L
Sbjct: 690 LYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKL----- 744
Query: 181 RLKKEEEDRIVTQNRVFAYLCK---RVPHTVLDRQLLCLIDYYESKIRKIHTQR---QYK 234
L+ E+ ++ + +++ +L + V ++ ++ ++ + KI+ ++ ++
Sbjct: 745 -LENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQ 803
Query: 235 EDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQH 294
DE E E + + L Q +E KS + EK+ L+K+LE
Sbjct: 804 RDEKVLELEKEIKCLQEESVV---------QCEELKSLLRDYEQEKVLLRKELE------ 848
Query: 295 ELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCS 354
+++ ++AL+ +L+ K A +E ++ Q LI CS
Sbjct: 849 -------EIQSEKEALQ-----SDLLEMKNA------NEKTRLENQNLLIQVEEVSQTCS 890
Query: 355 INSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLK 414
S IHN + I K+ + + ++D E L+ + + A + D S+K
Sbjct: 891 -KSEIHNEKEKCFI-KEHENLKPLLEQKELRDRRAE-LILLKDSLAKSPSVKNDPLSSVK 947
Query: 415 TLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDS 458
L ++ NL+K+ + + K+ + + +E+++ K++
Sbjct: 948 ELEEKIE---NLEKECKEKEEKINKIKLVAVKAKKELDSSRKET 988
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 59.7 bits (143), Expect = 7e-09
Identities = 86/375 (22%), Positives = 152/375 (40%), Gaps = 52/375 (13%)
Query: 6 PKPQDSSQPSDRLMTEKQQEEAEWESI------NVLLMMHGLKPLSLVKRTDLKDLIIFD 59
P + ++ L+ EKQQE + + + + +K L V+ KDL I
Sbjct: 2001 PGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITK 2060
Query: 60 KQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIM 119
+ +Q + K E S + + E + L + L+L++ +N+E + ++Q
Sbjct: 2061 ENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKD 2120
Query: 120 ESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEV 179
E ++ ++ + E++ L KE+K +Q K ++++ EETI +Q+ +
Sbjct: 2121 EDLERRLEQAEEKHL--------------KEKKNMQEKLDALRREKVHLEETIGEIQVTL 2166
Query: 180 CRLKKEEE------DRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQY 233
+ KE + D VTQ F K + DR +ID + RK Q
Sbjct: 2167 NKKDKEVQQLQENLDSTVTQLAAFT---KSMSSLQDDRDR--VIDEAKKWERKFSDAIQS 2221
Query: 234 KEDESQSEEEN------DYRNLDASPTYKGLLMSL---QNQLKESKSK---------IDA 275
KE+E + +E+N R + + +S Q+ ESK++ D
Sbjct: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT 2281
Query: 276 LSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKK-NVKLQELINHKKAEDTEKKDEP 334
L E L LE T+H + ++ KLE LK +L +L N + +K +
Sbjct: 2282 LQGENKELLSQLE--ETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLE 2339
Query: 335 SKYNQQQALIDQRYF 349
QQ+A I F
Sbjct: 2340 GIIRQQEADIQNSKF 2354
Score = 46.6 bits (109), Expect = 7e-05
Identities = 64/295 (21%), Positives = 115/295 (38%), Gaps = 24/295 (8%)
Query: 49 RTDLKDLI-IFDKQSSQRMRQNL---KLLVEETSCQQNMIQELIETNQQLRNELQLEQSR 104
R DL +I I D Q Q + L K L + + + ++E E N+ LR Q
Sbjct: 2537 REDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE 2596
Query: 105 AANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKK 164
+ + L+ + + ++ L++E H Q K+K ++E L +K+
Sbjct: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVK--EEEVHRLSALFSSSQKR 2654
Query: 165 RTEQEETIASLQMEVCRLKKEEEDRIVTQNRVF---AYLCKRVPHTVLDRQLLCLIDYYE 221
E EE + +Q E + E ED++ + + A + + T +R D E
Sbjct: 2655 IAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVE 2714
Query: 222 SKIRKIHTQRQYK----------EDESQSEEENDYRNLDASPTYKGLLMSLQN--QLKES 269
+ + + ++ K S + D+ N + + SL+ QLKE
Sbjct: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ 2774
Query: 270 ---KSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELIN 321
+ DAL SE E H +L +Q + K E+ L + +L++ N
Sbjct: 2775 GLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYN 2829
Score = 43.9 bits (102), Expect = 4e-04
Identities = 57/298 (19%), Positives = 125/298 (41%), Gaps = 30/298 (10%)
Query: 17 RLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEE 76
+L+T+ E + + VL SLV R + DL+ + ++++ Q L +++
Sbjct: 239 QLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQ 298
Query: 77 TSCQQNMIQELIETNQQ----LRNELQLEQSRAAN-----QEQRANDLEQIMES------ 121
+ N ++ +ET ++ L +++LE + QE+ + LEQ ++
Sbjct: 299 MEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAE 358
Query: 122 VKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCR 181
++S+ LE + + + + I LQK + LQ C K + ++ + ++ +
Sbjct: 359 LESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQ 418
Query: 182 LKKEEEDRIVTQNRVFAYLCKRVP---HTVLDRQLLCLIDYYESKIRKIHTQRQYKEDES 238
++ ED++ +++ + R+P H + D Y + + + +
Sbjct: 419 TIQQLEDQLQQKSKEISQFLNRLPLQQHETASQ--TSFPDVYNEGTQAVTEENIASLQKR 476
Query: 239 QSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHEL 296
E EN+ KG L+ +L+E K++ + LSS+ L+ T E+
Sbjct: 477 VVELENE----------KGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREV 524
Score = 43.1 bits (100), Expect = 7e-04
Identities = 92/540 (17%), Positives = 217/540 (40%), Gaps = 84/540 (15%)
Query: 45 SLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQ---QNMIQELIETNQQLRNELQLE 101
+L + L++ + + + +R+ ++L + + S Q ++ + + Q+ R++L E
Sbjct: 1495 ALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITE 1554
Query: 102 QSRAANQEQRAND-----------LEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKE 150
R+ + Q + L + E + +I L+ ++ + Q K K+LQKE
Sbjct: 1555 MDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKE 1614
Query: 151 QKTLQVKCQHYKKKRTEQEETIASLQME----VCRLKKEEEDRIVTQNRVFAYLCKRVPH 206
+ L ++ + + + +++ E +L+ E ++ T+ ++
Sbjct: 1615 YEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQL---------- 1664
Query: 207 TVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASP---TYKGLLMSLQ 263
++ ++ + K+RK +Q K E EEEND + P T K + +L
Sbjct: 1665 ----QEAEQEMEEMKEKMRKFAKSKQQKILE--LEEENDRLRAEVHPAGDTAKECMETLL 1718
Query: 264 NQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHK 323
+ K +++ + E L K ++ ++ + ++V+ L+ ++ NV Q
Sbjct: 1719 SSNASMKEELERVKMEYETLSKKFQSLMSEKD--SLSEEVQDLKHQIEGNVSKQ-----A 1771
Query: 324 KAEDTEKKDEPSKYNQQ--QALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNK 381
E TEK D + ++ Q++ + Q S+++ P + K +K
Sbjct: 1772 NLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMST---RPTCSESV-PSAKSANPAVSK 1827
Query: 382 DLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLL 441
D + + I+ +++ L++ + K S L ENE
Sbjct: 1828 DFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTL----------ENE-------- 1869
Query: 442 FIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRLGEMNN 501
+T+L ++ K+ + M LQ +V +N + ++ E +R+ ++
Sbjct: 1870 --KNTLLSQISTKDGELKM-----LQE---------EVTKMNLLNQQIQEELSRVTKLKE 1913
Query: 502 AVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQVMQVLGPEDLQSIIYKLEEHEE 561
++ LE + L L ++G C+ + + + + ++L+ + +LEE ++
Sbjct: 1914 TAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQ 1973
Score = 40.4 bits (93), Expect = 0.005
Identities = 63/303 (20%), Positives = 133/303 (43%), Gaps = 32/303 (10%)
Query: 68 QNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQ-RANDLEQIMESVKSKI 126
++LK + E +Q+ +E++Q LQ+ + Q + ++L++++ + +
Sbjct: 1354 ESLKTVSHEAEVHAESLQQKLESSQ-----LQIAGLEHLRELQPKLDELQKLISKKEEDV 1408
Query: 127 GELEDESLSRACHQQNKIKDLQKEQKTLQVKCQH--YKKKRTEQEETIASLQMEVCRLKK 184
L + LS KI+ EQ+ L +K H + + E +E I LQ+E+C +K+
Sbjct: 1409 SYLSGQ-LSEKEAALTKIQTEIIEQEDL-IKALHTQLEMQAKEHDERIKQLQVELCEMKQ 1466
Query: 185 EEED-------RIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDE 237
+ E+ + Q ++ A L R ++ L + I ++ + + E
Sbjct: 1467 KPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERL--TKSLADVE 1524
Query: 238 SQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELR 297
SQ +N ++ T G L LQ + + +++D E +L E+ L+
Sbjct: 1525 SQVSAQNKEKD-----TVLGRLALLQEERDKLITEMDRSLLENQSLSSSCES------LK 1573
Query: 298 LYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINS 357
L + + + ++ L K +++ L + K AE TE +++ + ++ ++ Q Y V
Sbjct: 1574 LALEGLTEDKEKLVK--EIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAER 1631
Query: 358 IIH 360
I H
Sbjct: 1632 IQH 1634
Score = 40.0 bits (92), Expect = 0.006
Identities = 72/323 (22%), Positives = 127/323 (39%), Gaps = 52/323 (16%)
Query: 50 TDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQE 109
++L LI K+++ L EE + ++EL + QLE + A +
Sbjct: 719 SNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAER 778
Query: 110 QRANDLEQIMES---VKSKIGELEDESLSRACH---QQNKIKDLQ---KEQKTLQVKCQH 160
QR D E + +I L E+ S+ QN++ D+Q EQ TL ++
Sbjct: 779 QRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTL-IRSLQ 837
Query: 161 YKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYY 220
+ + E E + ++ K EE + ++Q K + T +D+ LL
Sbjct: 838 SQLQNKESEVLEGAERVRHISSKVEELSQALSQ--------KELEITKMDQLLL------ 883
Query: 221 ESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALS--- 277
K R + T +Q E++ Q E + + SL ++K K +++ LS
Sbjct: 884 -EKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAE 942
Query: 278 -SEKLNLQKDLET-------------------RPTQHELRLYK----QQVKKLEKALKKN 313
++K +++D E QHE L K Q+ +KL+ AL
Sbjct: 943 EAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINR 1002
Query: 314 VKLQELINHKKAEDTEKKDEPSK 336
+L + ++ + E KDE K
Sbjct: 1003 KELLQRVSRLEEELANLKDESKK 1025
Score = 38.1 bits (87), Expect = 0.023
Identities = 66/311 (21%), Positives = 126/311 (40%), Gaps = 50/311 (16%)
Query: 59 DKQSSQRMRQNLKLLVEETSCQQN---MIQELIETNQQLRNELQLEQSRAANQEQRAND- 114
+K+ SQ + L+ + S + M+QE + L ++Q E SR ++ A +
Sbjct: 1859 NKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEE 1918
Query: 115 LEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIAS 174
+ + E + +++ EL S+ C + D Q + + L+ + ++ KK +E EE
Sbjct: 1919 KDDLEERLMNQLAELNG-SIGNYCQD---VTDAQIKNELLESEMKNLKKCVSELEE---- 1970
Query: 175 LQMEVCRLKKE--------------------EEDRIVTQNRVFAYLCKRVPHTVLDRQLL 214
E +L KE +E + + L K V Q
Sbjct: 1971 ---EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKD 2027
Query: 215 CLIDYYE--SKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSK 272
C I Y E S + + ++ + ESQ + E NL + ++ Q +L K
Sbjct: 2028 C-IRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR---KKAQAELASFKVL 2083
Query: 273 IDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKD 332
+D SE + D L+L K++++ ++++K +K ++ ++ E E+K
Sbjct: 2084 LDDTQSEAARVLAD--------NLKL-KKELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134
Query: 333 EPSKYNQQQAL 343
K N Q+ L
Sbjct: 2135 LKEKKNMQEKL 2145
Score = 33.1 bits (74), Expect = 0.75
Identities = 52/256 (20%), Positives = 114/256 (44%), Gaps = 28/256 (10%)
Query: 89 ETNQQLRNELQLEQSRAANQEQRANDLEQIMESV---KSKIGELEDESLSRACHQQNKIK 145
+T+Q +R L E + ++ E E + E + + + EL+D + Q K +
Sbjct: 21 DTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDE 80
Query: 146 DLQKEQKTLQVKCQ----HYKKKRTEQEETIASLQME---VCRLKKEEEDRIVTQNRVFA 198
LQ+E+K K + H K K T + I ++ + V + + E+++ ++
Sbjct: 81 ALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSST 140
Query: 199 ---YLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTY 255
+++ H + +++ L S ++ TQ Q ++ S E ++ +
Sbjct: 141 EEEMEIEKIKHKLQEKEELI------STLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQE 194
Query: 256 K-GLLMSLQNQLKESKSKIDALSSEKLNLQKD--LETRPTQHE---LRLYKQQVKKLEKA 309
K + +LQ QL +++++ +++++ +KD ET+ HE L+L Q + E
Sbjct: 195 KEEFISTLQAQLSQTQAE---QAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQ 251
Query: 310 LKKNVKLQELINHKKA 325
K V ++L H+++
Sbjct: 252 QKLRVLQRKLEEHEES 267
>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
Length = 495
Score = 59.3 bits (142), Expect = 1e-08
Identities = 67/271 (24%), Positives = 125/271 (46%), Gaps = 31/271 (11%)
Query: 73 LVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDE 132
LV+E C++ +Q L N Q+RN Q+ Q+ N+ QR +Q + ++++ EL+ E
Sbjct: 17 LVDENYCKKLHVQALKNVNSQIRN--QMVQNENDNRVQR----KQFLRLLQNEQFELDME 70
Query: 133 SLSRACHQQNKIKDLQ-KEQKTLQV---KCQHYKKKRTEQEETIASLQMEVCRLKKEEED 188
+ + ++K+LQ K+++ L + K +H K + + + +E+ L+K+ +
Sbjct: 71 EAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLK- 129
Query: 189 RIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEEN---D 245
AY+ K + ++ I Y + K + +E + +EEN D
Sbjct: 130 --------AAYMNKERAAQIAEKD---AIKYEQMKRDAEIAKTMMEEHKRIIKEENAAED 178
Query: 246 YRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKK 305
RN + Y L L+ Q K+ + + L EKL + D R E +L KQQ +
Sbjct: 179 KRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMI--DEIVRKIYEEDQLEKQQKLE 236
Query: 306 LEKALKKNV----KLQELINHKKAEDTEKKD 332
A+++ + K Q L KK E+ E+++
Sbjct: 237 KMNAMRRYIEEFQKEQALWRKKKREEMEEEN 267
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 58.9 bits (141), Expect = 1e-08
Identities = 71/311 (22%), Positives = 143/311 (45%), Gaps = 35/311 (11%)
Query: 59 DKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQL----RNELQLEQ--SRAANQEQRA 112
++ +R +Q LK +E QQ + +E E +Q E +LEQ R +E+R
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682
Query: 113 NDL-----EQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTE 167
+L EQ E +KS+I + + + S A +Q+K+ ++Q+ Q + Q ++KR
Sbjct: 683 QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG-QRRRQEQEEKRRR 741
Query: 168 QEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLC----LIDYYESK 223
+E + + E +++EE+ Q R F + + + RQ L L + E +
Sbjct: 742 RESELQWQEEERAHRQQQEEE----QRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQ 797
Query: 224 IRKIHTQRQYKEDE-SQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLN 282
+R +RQ +E EEE + R K L + + + + + L E+
Sbjct: 798 LRA--EERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDG 855
Query: 283 LQKDLETRPTQHELR--LYKQQVKKLEK----------ALKKNVKLQELINHKKAEDTEK 330
LQ+D E R +Q + R ++ Q+++ K AL++ ++ ++ + ++ E+ ++
Sbjct: 856 LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQR 915
Query: 331 KDEPSKYNQQQ 341
++ + Q+Q
Sbjct: 916 EEREKRRRQEQ 926
Score = 57.4 bits (137), Expect = 4e-08
Identities = 66/301 (21%), Positives = 131/301 (43%), Gaps = 50/301 (16%)
Query: 60 KQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIM 119
+Q +R Q L+ + QQ ++ + QQLR E QL + + +EQ+ +Q+
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 120 ESVKSKIGELEDESLSRACHQQNKIKDLQKEQ-------KTLQVKCQHYKKKRTEQEETI 172
E E+E + Q+ + + L++EQ K + +H +++R +Q +
Sbjct: 427 R-------EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479
Query: 173 ASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQ 232
+ LK EEE+R Q R E ++R+ +R+
Sbjct: 480 QEEERRERWLKLEEEERREQQER------------------------REQQLRREQEERR 515
Query: 233 YKEDESQSEEENDYRNLDASPTYKGLLMSLQNQL--KESKSKIDALSSEKLNLQKDLETR 290
+ + Q EEE + L + + + QL +E + +++ E+ L+++ E R
Sbjct: 516 EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQ-RLKREQEER 574
Query: 291 PTQ--------HELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQA 342
Q + RL ++Q ++LE+ LK+ +++ L ++ E K++EP + +QQ
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKRE-EVERLEQEERREQRLKREEPEEERRQQL 633
Query: 343 L 343
L
Sbjct: 634 L 634
Score = 57.0 bits (136), Expect = 5e-08
Identities = 66/293 (22%), Positives = 132/293 (45%), Gaps = 27/293 (9%)
Query: 61 QSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQL----EQSRAANQEQRANDLE 116
Q +R + LKL EE QQ ++ + Q+ R E +L E+ R + + L
Sbjct: 480 QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539
Query: 117 QIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKK---RTEQEETIA 173
+ E + ++ + E+E ++ ++K Q+E++ +K + +++ + EQEE +
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599
Query: 174 SLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKI------ 227
RLK+EE +R+ + R L + P +QLL + E + +++
Sbjct: 600 Q------RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653
Query: 228 -HTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKES-KSKID----ALSSEKL 281
QR +E+E + E+ R + + L Q Q +E KS+I L SE
Sbjct: 654 RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713
Query: 282 NLQKDLETRPTQHE--LRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKD 332
Q + +RP + E R +Q+ K+ + + + +E + ++ E+ +++D
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766
Score = 51.6 bits (122), Expect = 2e-06
Identities = 66/310 (21%), Positives = 133/310 (42%), Gaps = 32/310 (10%)
Query: 59 DKQSSQRMRQNLKL---LVEETSCQQNMIQELIETNQQLRNELQL-------------EQ 102
+++ SQ R++ K L EE +++ + +QLR E QL E+
Sbjct: 861 ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREK 920
Query: 103 SRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYK 162
R QE++ + EQ+ + + + E E E R ++ KD + +QK Q+ + +
Sbjct: 921 RRRQEQERQYREEEQLQQEEEQLLRE-EREKRRRQERERQYRKDKKLQQKEEQLLGEEPE 979
Query: 163 KKRTEQEE----TIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLID 218
K+R ++ E LQ E +L +EE ++ Q Y K L ++ L+
Sbjct: 980 KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK----DELQQEEEQLLR 1035
Query: 219 YYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLL---MSLQNQLKESKSKIDA 275
K R +RQY+E+E +EE + + L + +L++ + ++
Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 276 LSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEK----K 331
EK Q+ + EL+ ++Q+ + E+ ++ +L+ ++ E+ +
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 332 DEPSKYNQQQ 341
+EP K +Q+
Sbjct: 1156 EEPEKRRRQE 1165
Score = 51.2 bits (121), Expect = 3e-06
Identities = 67/313 (21%), Positives = 140/313 (44%), Gaps = 33/313 (10%)
Query: 60 KQSSQRMRQNLKLLVEETSCQQNMIQEL-------IETNQQLRNELQLEQSRAANQEQRA 112
+Q +R Q L+ EE +Q + +E + QQLR E QL + + +EQ+
Sbjct: 354 EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 413
Query: 113 NDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQ-------KTLQVKCQHYKKKR 165
+Q+ + + E E+E + Q+ + + L++EQ K + +H +++R
Sbjct: 414 RREQQLRREQQLR-REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472
Query: 166 TEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIR 225
+Q + + LK EEE+R Q R L R Q L + E +
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQL--RREQEERREQRLKRQEEEERLQQ 530
Query: 226 KIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQK 285
++ +++Q + ++ + E+ R + + L+ + +E + ++ L E+ Q+
Sbjct: 531 RLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL--LKREEERRQQ 588
Query: 286 DLETRPTQH-ELRLYKQQVKKLEKALKKNVKL----------QELINHKKAEDTEKKDEP 334
L+ + E RL +++V++LE+ ++ +L Q+L+ K+E+ E++ +
Sbjct: 589 RLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL---KSEEQEERRQQ 645
Query: 335 SKYNQQQALIDQR 347
+QQ +QR
Sbjct: 646 QLRREQQERREQR 658
Score = 50.1 bits (118), Expect = 6e-06
Identities = 68/363 (18%), Positives = 162/363 (44%), Gaps = 48/363 (13%)
Query: 5 APKPQDSSQPSDRLMTEKQQE-------EAEWESINVLLMMHGLKPLSLVKRTDLKDLII 57
A + SQ +L+ E+++E + ++ LL +PL +R D K
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER-DRK---- 1361
Query: 58 FDKQSSQRMRQNLKLLVEETSCQ-QNMIQELIETNQQLRNELQLEQSRAANQEQRANDLE 116
F ++ + Q K L EE + Q ++ ++ QQLR + + +Q R + + +
Sbjct: 1362 FREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQ 1421
Query: 117 QIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQ 176
Q+ + + E++ + R Q+ + K L++EQ Q++ + ++K R E++ +
Sbjct: 1422 QLSRQERDRKFREEEQQVRR---QERERKFLEEEQ---QLRQERHRKFREEEQLLQEREE 1475
Query: 177 MEVCRLKK-----EEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQR 231
++ R ++ EEE ++ Q R + + + +R+ L E ++ + QR
Sbjct: 1476 QQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFL----EEEQQLHRQQRQR 1531
Query: 232 QYKEDESQ--SEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLET 289
++ ++E Q +E R D ++ + QL++ + ++ L
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFRE-----EEQLRQERE------------EQQLSR 1574
Query: 290 RPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYF 349
+ + RL +Q+V++ E+ +K ++ ++ + ++ + +++ K+ + + L+ +R
Sbjct: 1575 QERDRKFRLEEQKVRRQEQE-RKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633
Query: 350 QVL 352
Q L
Sbjct: 1634 QQL 1636
Score = 49.7 bits (117), Expect = 8e-06
Identities = 64/286 (22%), Positives = 125/286 (43%), Gaps = 22/286 (7%)
Query: 53 KDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRA 112
++ ++ ++ +R ++ K EE QQ Q L E ++ R + Q R ++ Q+
Sbjct: 970 EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029
Query: 113 NDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETI 172
+ E K ++ E E + QQ + + L +E++T + Q +++ ++EE
Sbjct: 1030 EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR--RRQELERQYRKEEE-- 1085
Query: 173 ASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQ 232
LQ E +L +EE ++ Q R C+ L ++ L+ K R+ +RQ
Sbjct: 1086 --LQQEEEQLLREEPEKRRRQER--ERQCREEEE--LQQEEEQLLREEREKRRRQELERQ 1139
Query: 233 YKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPT 292
Y+E+E +EE L K L+ Q +E + L E+ L ++ + +
Sbjct: 1140 YREEEEVQQEE---EQLLREEPEKRRRQELERQYREE----EELQQEEEQLLREEQEKRR 1192
Query: 293 QHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYN 338
Q R Y++ E+ L++ + Q + + D + + EP K N
Sbjct: 1193 QERERQYRE-----EEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233
Score = 47.8 bits (112), Expect = 3e-05
Identities = 63/345 (18%), Positives = 153/345 (44%), Gaps = 31/345 (8%)
Query: 9 QDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQ---SSQR 65
Q +P R ++Q++E E + G + +R + +D D++ Q
Sbjct: 128 QLEEEPGQRRRQKRQEQERE--------LAEGEEQSEKQERLEQRDRQRRDEELWRQRQE 179
Query: 66 MRQNLKLLVEET---SCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESV 122
++ + EE SC+ + +E + Q R EL LE R +E++ E+
Sbjct: 180 WQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL-LELRRKGREEKQQQRRER----- 233
Query: 123 KSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRL 182
+ ++ + E+E R + L+KE++ LQ + +++ E+EE + L+ + R
Sbjct: 234 QDRVFQEEEEKEWR-----KRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRR 288
Query: 183 KKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEE 242
+++EE++ + R L ++ ++Q + ++ ++Q + ++ + E
Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERRE 348
Query: 243 ENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQ---HELRLY 299
+ R + + L + + +E + + + + L+++ + R Q E +L
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 408
Query: 300 KQQVKKLEKALKKNVKL---QELINHKKAEDTEKKDEPSKYNQQQ 341
++Q + E+ L++ +L QE H++ + E++++ K Q++
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE 453
Score = 44.7 bits (104), Expect = 2e-04
Identities = 70/353 (19%), Positives = 142/353 (40%), Gaps = 38/353 (10%)
Query: 7 KPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRM 66
+ ++ + RL +E+Q + E LL K L +R ++ +R
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQR-----LKREQEERR 575
Query: 67 RQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKI 126
Q LK EE QQ + +E ++L L+ E+ QE+R + K
Sbjct: 576 DQLLKR--EEERRQQRLKRE---QEERLEQRLKREEVERLEQEERREQ--------RLKR 622
Query: 127 GELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIAS-LQMEVCRLKKE 185
E E+E + + + + Q++ + Q + + + KR E+EE + L+ E ++E
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682
Query: 186 EEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKI----RKIHTQRQYKEDESQ-- 239
+E Q + + R+P QL D +SK+ RK QR+ +E E +
Sbjct: 683 QELAEEEQEQARERIKSRIPK--WQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR 740
Query: 240 --------SEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRP 291
EEE +R + Q + K + + + L Q++ + R
Sbjct: 741 RRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRA 800
Query: 292 ---TQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQ 341
Q E R ++ +K ++ ++ + +EL ++ E ++++ + +++
Sbjct: 801 EERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEE 853
Score = 44.7 bits (104), Expect = 2e-04
Identities = 56/299 (18%), Positives = 138/299 (46%), Gaps = 36/299 (12%)
Query: 59 DKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQI 118
++Q S++ R L E+ +Q ++ +E QQLR + +Q R + D EQ+
Sbjct: 1569 EQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRED-EQL 1627
Query: 119 MESVKSKIGELEDESLSRACHQQNKIKD---LQKEQKTLQVKCQHYKKKRTEQEETIASL 175
++ E E++ L R + +++ L+++++ Q++ H + ++ +EE +
Sbjct: 1628 LQ-------EREEQQLHRQERDRKFLEEEPQLRRQEREQQLR--HDRDRKFREEEQLLQ- 1677
Query: 176 QMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKE 235
+ E +L+++E DR + +++ +R+ L E ++R+ +R+++E
Sbjct: 1678 EGEEQQLRRQERDRKFREEE------QQLRRQERERKFL----QEEQQLRRQELERKFRE 1727
Query: 236 DESQSEEENDYRNLDASPTYKGLLMSLQ-------NQLKESKSKIDALSSEKLNLQKDLE 288
+E Q +E + L Y+ +L Q QL+ + E+L +++ +
Sbjct: 1728 EE-QLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQ 1786
Query: 289 TRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQR 347
+Q R ++++ + ++ ++ ++ Q+ + E+ + + E Q+Q L +R
Sbjct: 1787 QLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLE----EQEQRLRQER 1841
Score = 42.4 bits (98), Expect = 0.001
Identities = 44/252 (17%), Positives = 112/252 (44%), Gaps = 16/252 (6%)
Query: 91 NQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGEL-EDESLSRACHQQNKIKDLQK 149
+ QLR+ + + EQ+ D EQ + + E+E L R ++ K +D +K
Sbjct: 1255 DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD-RK 1313
Query: 150 EQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVL 209
Q+ Q+ + ++KR Q ET + E L++ EE + Q R + + + H
Sbjct: 1314 SQEEKQLLREEREEKRRRQ-ETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ 1372
Query: 210 DRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKES 269
R+ L E ++R+ +R++ ++E Q L + L + +E
Sbjct: 1373 GRKFL----EEEQRLRRQERERKFLKEEQQ---------LRCQEREQQLRQDRDRKFREE 1419
Query: 270 KSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTE 329
+ ++ ++ +++ + R + E + +++ + ++ +K + ++L+ ++ +
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479
Query: 330 KKDEPSKYNQQQ 341
+++ K+ +++
Sbjct: 1480 RQERDRKFLEEE 1491
Score = 39.3 bits (90), Expect = 0.010
Identities = 57/279 (20%), Positives = 123/279 (44%), Gaps = 22/279 (7%)
Query: 75 EETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESL 134
+E Q ++L + +QL E + E+ R +E++ + E++ + + + E ++
Sbjct: 954 QERERQYRKDKKLQQKEEQLLGE-EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRR 1012
Query: 135 SRACHQQNKIKD-LQKEQKTL------QVKCQHYKKKRTEQEETIASLQMEVCRLKKEEE 187
+ +Q + KD LQ+E++ L + + Q +++ E+EE LQ E +L EE
Sbjct: 1013 RQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEE----LQQEEEQLLGEER 1068
Query: 188 DRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYR 247
+ Q Y + L ++ L+ K R+ +RQ +E+E +EE
Sbjct: 1069 ETRRRQELERQYRKEEE----LQQEEEQLLREEPEKRRRQERERQCREEEELQQEE---E 1121
Query: 248 NLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLE 307
L K L+ Q +E + + E+ L+++ E R Q R Y+++ + +
Sbjct: 1122 QLLREEREKRRRQELERQYREEE---EVQQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178
Query: 308 KALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQ 346
+ + + QE ++ +++E + ++Q D+
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE 1217
Score = 38.5 bits (88), Expect = 0.018
Identities = 56/296 (18%), Positives = 127/296 (42%), Gaps = 35/296 (11%)
Query: 49 RTDLKDLIIFDKQSSQRMRQNLKL---LVEETSCQQNMIQELIETNQQLRNELQLEQSRA 105
R D + ++F + +Q L L EE + + + L++ +Q ++ + E
Sbjct: 68 RVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDR 127
Query: 106 ANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKR 165
+E+ Q + + ++ E E++S + +Q + +E + + Q +++R
Sbjct: 128 QLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERR 187
Query: 166 TEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIR 225
E+E Q++ C+ + EE Q R R+LL L + +
Sbjct: 188 AEEE------QLQSCKGHETEEFPDEEQLR--------------RRELLEL--RRKGREE 225
Query: 226 KIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQK 285
K +R+ ++ Q EEE ++R + +L + +L+E + + E+ +
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRET------VLRKEEEKLQEEEPQRQRELQEEEEQLR 279
Query: 286 DLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQ 341
LE + ELR +Q+ ++ ++ L++ +L+ ++ E E++ E + +QQ
Sbjct: 280 KLE----RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQ 331
Score = 38.5 bits (88), Expect = 0.018
Identities = 76/349 (21%), Positives = 136/349 (38%), Gaps = 67/349 (19%)
Query: 9 QDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLS---LVKRTDLKDLIIFDKQSSQR 65
Q Q DR E +Q E E + K L ++R + + + D+ R
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFR 1670
Query: 66 MRQNLKLLVEETSCQ-QNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKS 124
+ L EE + Q ++ E QQLR + + + Q+ R +LE+ +
Sbjct: 1671 EEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQ 1730
Query: 125 KIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKK 184
E E E L R Q+ K L++EQ R E+EE +L++
Sbjct: 1731 LRQETEQEQLRR---QERYRKILEEEQ------------LRPEREEQ---------QLRR 1766
Query: 185 EEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEEN 244
+E DR + RQ + E ++R + R+++E+E +E
Sbjct: 1767 QERDRKFREEEQL-------------RQ-----EREEQQLRSQESDRKFREEEQLRQERE 1808
Query: 245 DYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYK--QQ 302
+ L+ Q ++ K + + E+L L++ E R Q R Y+ +Q
Sbjct: 1809 E--------------QQLRPQQRDGKYRWE---EEQLQLEEQ-EQRLRQERDRQYRAEEQ 1850
Query: 303 VKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQV 351
EK+ ++ +L + K+ ++ E+K +QQ +QR+ QV
Sbjct: 1851 FATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQK-EEQRHRQV 1898
Score = 37.0 bits (84), Expect = 0.052
Identities = 55/309 (17%), Positives = 135/309 (43%), Gaps = 32/309 (10%)
Query: 60 KQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIM 119
+Q +R +Q + EE ++ +E +++ + E QL + +++R + ++
Sbjct: 1280 EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREER-EEKRRRQETDRKF 1338
Query: 120 ESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEV 179
+ + E E++ L R Q + + ++E+ ++ Q +K E+E+ + + E
Sbjct: 1339 REEEQLLQEREEQPLRR----QERDRKFREEE----LRHQEQGRKFLEEEQRLRRQERER 1390
Query: 180 CRLKKEEEDRI--------VTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQR 231
LK+E++ R ++R F +++ DR+ E ++R+ +R
Sbjct: 1391 KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK----FREEEQQVRRQERER 1446
Query: 232 QYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRP 291
++ E+E Q +E R+ + L + QL + L E+ +++ + +
Sbjct: 1447 KFLEEEQQLRQE---RHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKF 1503
Query: 292 TQHELRLYKQQVKKLE--------KALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQAL 343
+ ELR + + K LE + +K ++ ++ + ++ ++D K+ +++ L
Sbjct: 1504 REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL 1563
Query: 344 IDQRYFQVL 352
+R Q L
Sbjct: 1564 RQEREEQQL 1572
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 58.9 bits (141), Expect = 1e-08
Identities = 104/489 (21%), Positives = 212/489 (43%), Gaps = 46/489 (9%)
Query: 67 RQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKI 126
R++ L E ++ M +EL T +Q+ N++QL QS+ +++ DLE+ ++S ++I
Sbjct: 639 RESAFLRSENLELKEKM-KELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEI 697
Query: 127 GELED-------ESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEV 179
+L + L + KI DLQKE +V+ ++ + SL EV
Sbjct: 698 TKLTSLIDGKVPKDLLCNLELEGKITDLQKELNK-EVEENEALREEVILLSELKSLPSEV 756
Query: 180 CRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQ 239
RL+KE +D+ + + T +L + + ES+++ + + +D+
Sbjct: 757 ERLRKEIQDKSEELHII----------TSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLA 806
Query: 240 SEEENDYRNLDAS-PTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRL 298
+ + N Y++ D +K L M + + K + + ++ E +NL K E + L
Sbjct: 807 TTQSN-YKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSK--EAQKFDSSLGA 863
Query: 299 YKQQVK-KLEKALKKNVKLQELINHKK--AEDTEKKDEP-SKYNQQQALIDQRYFQVLCS 354
K ++ K ++ +K ++QE +N + E E +D +++ LI ++ Q L
Sbjct: 864 LKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEE 923
Query: 355 INSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDC--GFEHLVPVIEMWADQLTSLKDLYKS 412
+ ++ KQ + +Q L D + E + L SLK ++
Sbjct: 924 VKTLTQEKDD----LKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQET 979
Query: 413 LKTLSAELVPWL--NLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIV 470
+ TL +++ + NL ++ K E +V +K++D + QTL A V
Sbjct: 980 INTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGI------DKKQDLEAKNTQTLTADV 1033
Query: 471 SHFQKLFDVPSLNGVYPRMNEVYTRLGEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCR 530
+ + + + NE L +M +V +E L+ D ++ + + +L R
Sbjct: 1034 KDNEIIEQQRKIFSLIQEKNE----LQQMLESVIAEKEQLKTDLKENIEMTIENQEEL-R 1088
Query: 531 LINEDVNEQ 539
L+ +++ +Q
Sbjct: 1089 LLGDELKKQ 1097
Score = 52.4 bits (124), Expect = 1e-06
Identities = 66/315 (20%), Positives = 144/315 (45%), Gaps = 27/315 (8%)
Query: 46 LVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLR-------NEL 98
L K+ +LK + + K+ + + + ++ E+T+ NM ++L +N L+ EL
Sbjct: 1717 LEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEEL 1776
Query: 99 QLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKC 158
++ Q++ + L I+ K+ ++ + + Q KI++L+ + L
Sbjct: 1777 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLIT-- 1834
Query: 159 QHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLID 218
KK E ++ ++ ++ +LKK+ +D+ +T +++ + + + +
Sbjct: 1835 --LKKDVNETQKKVSEME----QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVM 1888
Query: 219 YYESKIRKIHTQRQYKEDE-SQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALS 277
+R++ + + D+ +S +E R+L+ K M L + KE+ K+
Sbjct: 1889 KERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARM-LSKEHKETVDKLREKI 1947
Query: 278 SEKL----NLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTE---K 330
SEK ++QKDL+ ++ EL+ Q+++K E L + VK ++HKK + E K
Sbjct: 1948 SEKTIQISDIQKDLD--KSKDELQKKIQELQKKELQLLR-VKEDVNMSHKKINEMEQLKK 2004
Query: 331 KDEPSKYNQQQALID 345
+ E + Q +D
Sbjct: 2005 QFEAQNLSMQSVRMD 2019
Score = 48.5 bits (114), Expect = 2e-05
Identities = 68/329 (20%), Positives = 138/329 (41%), Gaps = 26/329 (7%)
Query: 22 KQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQ 81
K+Q+E + N + G + + ++++ + Q Q +Q L + EE S Q
Sbjct: 1095 KKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQ 1154
Query: 82 NMIQELIETNQQLRN-ELQLEQSRAANQEQRANDLEQIMESVKS------KIGELEDESL 134
I E+ +L+N EL LE E A L + E VKS + EL+
Sbjct: 1155 KKINEIENLKNELKNKELTLEHMETERLEL-AQKLNENYEEVKSITKERKVLKELQKSFE 1213
Query: 135 SRACHQQNKIKDLQKE--QKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVT 192
+ H + I++++ Q ++K H K E +ETI L+ V E+ +I+
Sbjct: 1214 TERDHLRGYIREIEATGLQTKEELKIAHIHLK--EHQETIDELRRSV----SEKTAQIIN 1267
Query: 193 QNRVFAYLCKRVPHTVLDRQLLCLIDYYE--SKIRKIHTQRQYKEDESQSEEENDYRNLD 250
+ HT L ++ L + E ++++ ++ + E++ ++
Sbjct: 1268 TQDL------EKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDST 1321
Query: 251 ASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKAL 310
+ + L + +ES+ +I +L+ E+ NL+ E +H+ K+ +++ +
Sbjct: 1322 TLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHD--QLKEHIRETLAKI 1379
Query: 311 KKNVKLQELINHKKAEDTEKKDEPSKYNQ 339
+++ QE + K +D E S+ Q
Sbjct: 1380 QESQSKQEQSLNMKEKDNETTKIVSEMEQ 1408
Score = 48.5 bits (114), Expect = 2e-05
Identities = 96/566 (16%), Positives = 227/566 (40%), Gaps = 94/566 (16%)
Query: 7 KPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKP------------LSLVKRT---- 50
K Q+S ++ + K+++ E+ ++ M KP L L KR
Sbjct: 1378 KIQESQSKQEQSLNMKEKDN---ETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH 1434
Query: 51 DLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQ 110
D + +K QR+++ +L E+ + I+E++ + + EL++ QE+
Sbjct: 1435 DEMKSVAKEKDDLQRLQE---VLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEE 1491
Query: 111 RANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVK-----------CQ 159
N+L + +++I ++ + + QNKI+++ ++++ +K +
Sbjct: 1492 TINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELK 1551
Query: 160 HYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDY 219
+K+ R ++ + S++ ++ L ++ +Q + + ++ + L D
Sbjct: 1552 QFKEHRKAKDSALQSIESKMLELTNRLQE---SQEEIQIMIKEKEEMKRVQEALQIERDQ 1608
Query: 220 YESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGL--LMSLQNQLKESKSKIDALS 277
+ ++I K ESQ +E + + T + + + L+ Q + K ++ +
Sbjct: 1609 LKENTKEIVA----KMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIE 1664
Query: 278 SEKLNLQKDL-ETRPTQHELRLYKQQVKKLEKALK-KNVKLQELINHKKAEDTEKKDEPS 335
+E + L + L E + + ++ +E+ LK + +L+E + D EK++E
Sbjct: 1665 TENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELK 1724
Query: 336 KYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPV 395
+ + + + + + I+ + + N KDL EH
Sbjct: 1725 IVHMHL----KEHQETIDKLRGIV----------SEKTNEISNMQKDL------EHSNDA 1764
Query: 396 IEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKE 455
++ + LK + ++LK+Q E ++ L IV +++ N +
Sbjct: 1765 LKA------------QDLKIQEELRIAHMHLKEQQET----IDKLRGIVSEKTDKLSNMQ 1808
Query: 456 KD---SNMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRLGEMNNAVRNLQELLEL 512
KD SN + +Q + ++ +L + +NE ++ EM + ++
Sbjct: 1809 KDLENSNAKLQEKIQELKANEHQLITLKK------DVNETQKKVSEMEQLKKQIK----- 1857
Query: 513 DSSSSLCVLVSTVGKLCRLINEDVNE 538
D S +L L L + ++E++ E
Sbjct: 1858 DQSLTLSKLEIENLNLAQKLHENLEE 1883
Score = 45.1 bits (105), Expect = 2e-04
Identities = 113/533 (21%), Positives = 212/533 (39%), Gaps = 90/533 (16%)
Query: 61 QSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIME 120
+ +Q+ +L L E S + +QE + ++R N++EQ+ E
Sbjct: 852 KEAQKFDSSLGALKTELSYKTQELQE-----------------KTREVQERLNEMEQLKE 894
Query: 121 SVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVC 180
+LE+ + ++ K +K Q+TL+ + + +++ + ++ SLQ+E
Sbjct: 895 -------QLENRDSTLQTVEREKTLITEKLQQTLE-EVKTLTQEKDDLKQLQESLQIERD 946
Query: 181 RLKKEEED----RIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKED 236
+LK + D I TQ ++ L H L I E R +H + E
Sbjct: 947 QLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKIS--EEVSRNLHMEENTGET 1004
Query: 237 ESQSEEE----NDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLE---- 288
+ + +++ + ++L+A T N++ E + KI +L EK LQ+ LE
Sbjct: 1005 KDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIA 1064
Query: 289 ---------------TRPTQHELRLYKQQVKKLEK--------ALKKNVKLQELINHKKA 325
T Q ELRL ++KK ++ A+KK +L + + A
Sbjct: 1065 EKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCD-RLA 1123
Query: 326 EDTEKKDEPSKY---NQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKD 382
E EK E S+ QQQ L Q + + I N + + + T ++ +
Sbjct: 1124 EVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLE 1183
Query: 383 LVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLF 442
L Q + ++ + LK+L KS +T L ++ ++ E G++ ++ L
Sbjct: 1184 LAQKLNENY--EEVKSITKERKVLKELQKSFETERDHLRGYI---REIEATGLQTKEELK 1238
Query: 443 IVDTMLEEVEN---------KEKDSNMPHFQTLQAIVSHFQKLFDVPSLN---GVYPRMN 490
I L+E + EK + + + Q L+ SH + ++P L+ + P +
Sbjct: 1239 IAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEK--SHTKLQEEIPVLHEEQELLPNVK 1296
Query: 491 EVYTRLGEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQVMQV 543
EV E + L+ L E ++ L + RL NE E ++
Sbjct: 1297 EV----SETQETMNELELLTEQSTTKDSTTLARIEMERLRL-NEKFQESQEEI 1344
Score = 42.4 bits (98), Expect = 0.001
Identities = 112/555 (20%), Positives = 218/555 (39%), Gaps = 93/555 (16%)
Query: 16 DRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVE 75
D L+ + +Q E E + L L ++ DL + ++++ + L +
Sbjct: 508 DNLVLDYEQLRTEKEEME----------LKLKEKNDLDEFEALERKTKKDQEMQL---IH 554
Query: 76 ETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLS 135
E S +N+++ NQ L NEL + +E + L++ ++S K LE+ +
Sbjct: 555 EISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQK-----LENIKMD 609
Query: 136 RACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNR 195
+ ++ Q +Q + KR A L+ E LK++ ++ T
Sbjct: 610 LSYSLESIEDPKQMKQTLFDAETVALDAKRES-----AFLRSENLELKEKMKELATTY-- 662
Query: 196 VFAYLCKRVPHTVLDRQLLCLIDYYESKI---RKIHTQRQYKEDESQSEEENDYRNLDAS 252
+Q+ I Y+S++ +K+ + KE +S E +L
Sbjct: 663 ---------------KQMENDIQLYQSQLEAKKKMQVDLE-KELQSAFNEITKLTSLIDG 706
Query: 253 PTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKK 312
K LL +L E + KI L E L K++E E + ++K L ++
Sbjct: 707 KVPKDLLCNL-----ELEGKITDLQKE---LNKEVEENEALREEVILLSELKSLPSEVE- 757
Query: 313 NVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQT 372
+L++ I K E E K + + R +L I + YK T
Sbjct: 758 --RLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKST 815
Query: 373 KGGVQNFNKDLVQDCGFEHLVPVI----EMWADQLTSLKDLYKSLKTLSAELVPWLNLKK 428
QNF K L D FE ++ E ++ +L + + L L+ K
Sbjct: 816 DQEFQNF-KTLHMD--FEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKT 872
Query: 429 QDENEGIK-VEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGVYP 487
Q+ E + V++ L ++ + E++EN +DS + + + +++ +KL
Sbjct: 873 QELQEKTREVQERLNEMEQLKEQLEN--RDSTLQTVEREKTLIT--EKL---------QQ 919
Query: 488 RMNEVYTRLGEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQV-MQVLGP 546
+ EV T L + + ++ LQE L+++ + D+++ V M +
Sbjct: 920 TLEEVKT-LTQEKDDLKQLQESLQIERDQ---------------LKSDIHDTVNMNIDTQ 963
Query: 547 EDLQSIIYKLEEHEE 561
E L++ + L++H+E
Sbjct: 964 EQLRNALESLKQHQE 978
Score = 39.7 bits (91), Expect = 0.008
Identities = 97/503 (19%), Positives = 195/503 (38%), Gaps = 99/503 (19%)
Query: 52 LKDLIIFDKQSSQRMRQNL---KLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQ 108
L L I + +Q++ +NL K +++E + + + L QL+ LQ ++R
Sbjct: 1863 LSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEI 1922
Query: 109 EQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQ 168
+Q + + K + +L ++ + + KDL K + LQ K Q +KK +
Sbjct: 1923 QQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQL 1982
Query: 169 EETIASLQM------EVCRLKKEEEDRIVTQN--RVFAYLCKRVPHTVLDRQLLCLIDYY 220
+ M E+ +LKK+ E + ++ R+ + + H L+ + ++
Sbjct: 1983 LRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEE--IRIVAKE 2040
Query: 221 ESKIRKIHTQRQYKEDE----SQSEEENDYRNLDASPTYKGLLMSLQNQLKES------- 269
++R+I + + D+ + D +N P K LL Q L ES
Sbjct: 2041 RDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPE-KRLLSDGQQHLTESLREKCSR 2099
Query: 270 -----------KSKIDALSSEKLNLQKDLE-----TRPTQHELRLYKQQVKKLEKALKKN 313
+ L+ L+L+K++E + + L L Q K +EK N
Sbjct: 2100 IKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTAN 2159
Query: 314 -----------VKLQELINHKKAEDTEKKDEPSKY---------NQQQALIDQRYFQVLC 353
KL+ ++++ E+ + +K+ Q++ LI ++ Q C
Sbjct: 2160 QRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDC 2219
Query: 354 SINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQ-----LTSLKD 408
+ S ++ + N N DL H+ +++ +++ T +
Sbjct: 2220 DVPS------------RELRDLKLNQNMDL-------HIEEILKDFSESEFPSIKTEFQQ 2260
Query: 409 LYKSLKTLSAELVPWLNLK---------KQDENEGIKVEDLLF---IVDTMLEEVENKEK 456
+ + K ++ L WLN + Q EN+ I + F I+ M E E +E+
Sbjct: 2261 VLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEER 2320
Query: 457 DSNMPH--FQTLQAIVSHFQKLF 477
+ + Q L+++ +KLF
Sbjct: 2321 SATISKEWEQDLKSLKEKNEKLF 2343
Score = 38.9 bits (89), Expect = 0.014
Identities = 72/333 (21%), Positives = 156/333 (46%), Gaps = 37/333 (11%)
Query: 30 ESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIE 89
E+I+ L K ++ DL+ +S ++++ + +L EE N ++E+ E
Sbjct: 1249 ETIDELRRSVSEKTAQIINTQDLE-------KSHTKLQEEIPVLHEEQELLPN-VKEVSE 1300
Query: 90 TNQQLRNELQL--EQSRAANQEQRAN-DLEQIMESVKSKIGELEDESLSRACHQQNKIKD 146
T Q+ NEL+L EQS + A ++E++ + K + + E +SL++ IK+
Sbjct: 1301 T-QETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKE 1359
Query: 147 LQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEED-RIVTQNRVF-----AYL 200
E K Q+K +H ++ + +E+ + + + +K+ E +IV++ F A L
Sbjct: 1360 AL-EVKHDQLK-EHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL 1417
Query: 201 CKRVPHTVLDRQLLCLIDYYESKIRK---IHTQRQYKEDESQSEEENDY----RNLDASP 253
+ L ++L D +S ++ + ++ + ES +EN ++L+
Sbjct: 1418 RIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEE 1477
Query: 254 TYKGLLMSLQNQ---LKESKSKIDALSSEKLNLQKDLET--RPTQHELR-LYKQQ----V 303
K L+ Q + E + + +E +QK LE Q++++ +Y+++ +
Sbjct: 1478 ELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNI 1537
Query: 304 KKLEKALKKNVKLQELINHKKAEDTEKKDEPSK 336
K++ + +K +L++ H+KA+D+ + SK
Sbjct: 1538 KQISEVQEKVNELKQFKEHRKAKDSALQSIESK 1570
Score = 37.4 bits (85), Expect = 0.040
Identities = 54/256 (21%), Positives = 109/256 (42%), Gaps = 41/256 (16%)
Query: 113 NDLEQIMESVKSK----------IGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYK 162
N L +I ESV S+ + E+E ++ +Q+N +L + Y+
Sbjct: 456 NLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYE 515
Query: 163 KKRTEQEETIASLQME---------VCRLKKEEEDRIVTQNRVFAYLCK--RVPHTVLDR 211
+ RTE+EE L+ + + KK++E +++ + L K V + L+
Sbjct: 516 QLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLEN 575
Query: 212 QLLCLIDYYESKIRKIHTQRQYKEDESQSEEEND----YRNLDASPTYKGLLMSLQNQLK 267
+L ++ K +I ++Y + + + D +++ K L +
Sbjct: 576 ELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVAL 635
Query: 268 ESKSKIDALSSEKLNLQ---KDLET--RPTQHELRLYKQQV-----------KKLEKALK 311
++K + L SE L L+ K+L T + +++++LY+ Q+ K+L+ A
Sbjct: 636 DAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFN 695
Query: 312 KNVKLQELINHKKAED 327
+ KL LI+ K +D
Sbjct: 696 EITKLTSLIDGKVPKD 711
Score = 33.9 bits (76), Expect = 0.44
Identities = 81/393 (20%), Positives = 151/393 (38%), Gaps = 101/393 (25%)
Query: 13 QPSDRLMTEKQQEEAE-----WESINVLLMMHG--------LKPLSLVKRTDLKDLIIFD 59
+P RL+++ QQ E I LL + L LSL DL+ I F
Sbjct: 2076 KPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSL----DLEKEIEFQ 2131
Query: 60 KQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNE-----------------LQLEQ 102
K+ S R++ NL L +T I++L NQ+ E ++ EQ
Sbjct: 2132 KELSMRVKANLSLPYLQTK----HIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQ 2187
Query: 103 SRAAN------------QEQRANDLEQIMESVKSKIGELEDESLSRAC--HQQNKIKDLQ 148
+ N Q++ ++ + + EL D L++ H + +KD
Sbjct: 2188 HESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFS 2247
Query: 149 KEQ----KTLQVKCQHYKKKRTEQEETIASLQMEVCRLK---KEEEDRIVTQNRVFAYLC 201
+ + KT + +K+ T+ E + + ++ +LK ++E DRI N F
Sbjct: 2248 ESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFN--- 2304
Query: 202 KRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEEND-----YRNLDAS---- 252
+R + + + E + R +++++D +E+N+ Y+ L S
Sbjct: 2305 --------NRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASG 2356
Query: 253 ----PTYKG----------------LLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPT 292
PT + + L+N L E+K S+ + +QK+LE T
Sbjct: 2357 AQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEV--T 2414
Query: 293 QHELRLYKQQVKKLEKALKKNVKLQELINHKKA 325
+ + +V + K L+K + +++ K A
Sbjct: 2415 NDIIAKLQAKVHESNKCLEKTKETIQVLQDKVA 2447
Score = 29.6 bits (65), Expect = 8.2
Identities = 22/98 (22%), Positives = 48/98 (48%), Gaps = 7/98 (7%)
Query: 93 QLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQK 152
+++ EL++ A + + ++ + +E K I L+D+ A + +I+DL + K
Sbjct: 2406 KMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDL--KMK 2463
Query: 153 TLQVKCQHYKKKRTEQEETIAS-----LQMEVCRLKKE 185
+++ + K + ++E A+ Q EV RL +E
Sbjct: 2464 LVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRE 2501
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 58.2 bits (139), Expect = 2e-08
Identities = 107/517 (20%), Positives = 224/517 (43%), Gaps = 69/517 (13%)
Query: 59 DKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQI 118
DKQ Q +L + + ++ ++++ N L+ E+Q Q+ A Q A++LE++
Sbjct: 613 DKQIKQT-EDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKM 671
Query: 119 MESV---KSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASL 175
+SV KI LE++ ++ + K L + K L+ + Q + +EQ
Sbjct: 672 QQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVE 731
Query: 176 QMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQ--Y 233
QME C +K+E+ + V + +L+ L+ + E ++ I T+
Sbjct: 732 QMEKCIQEKDEKLKTVEE--------------LLETGLI-QVATKEEELNAIRTENSSLT 776
Query: 234 KEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKI----DALSSEKLNL-QKDLE 288
KE + ++ND ++ L+ L+ + E KI + L +E L + K+
Sbjct: 777 KEVQDLKAKQND------QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKT 830
Query: 289 TRPTQHELRLYKQQV--KKLEKALKKNV--KLQELINHKKAEDTEKKDEPSKYNQQQALI 344
+ + E++ K+++ +LEKA + ++ K+QEL N K ++ + N +A++
Sbjct: 831 VQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKE-------EQMNTMKAVL 883
Query: 345 DQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLT 404
+++ + + + + + Q+ K+ FE L V++ ++
Sbjct: 884 EEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLK---EKEN 940
Query: 405 SLKDLYKSLKTLSAELVPWLNLKK--QDENEGIK--VEDLLFIVDTMLEEVENKEKDSNM 460
LK L LK ++L L + QDEN+ K +E L + +N ++ S+
Sbjct: 941 ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQL---------KQQNYQQASSF 991
Query: 461 PHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRLGEMNNAVRNLQELLELDSSSSLCV 520
P + L ++S +K ++G++ ++ + + +L+E + ++
Sbjct: 992 PPHEELLKVISEREK-----EISGLWNELDSLKDAVEHQRKKNNDLRE----KNWEAMEA 1042
Query: 521 LVSTVGKLCRLINEDVNEQVMQVLGPE-DLQSIIYKL 556
L ST L +N+ E+ QV E + + ++ KL
Sbjct: 1043 LASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKL 1079
Score = 54.7 bits (130), Expect = 2e-07
Identities = 92/481 (19%), Positives = 212/481 (44%), Gaps = 38/481 (7%)
Query: 4 VAPKPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDL-KDLIIFDKQS 62
+A +D++ DR Q+ E E NV++ + +L K ++ ++ I Q
Sbjct: 341 LAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE 400
Query: 63 SQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNEL-----QLEQSRAANQEQRANDLEQ 117
+Q+M+ + + E+ + I L + N LR+ + QLE ++A + D +
Sbjct: 401 TQQMQMKFQQVREQMEAE---IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYAR 457
Query: 118 IMESVKSKIGELEDESLSRACHQQ--NKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASL 175
++ + K G+L+ E + + +Q ++K +E + + Q Y +KRT + E A
Sbjct: 458 LVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEA-AQQ 516
Query: 176 QMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRK-----IHTQ 230
++ + KE E + + + K+ L+++L+ L++ + ++ K + Q
Sbjct: 517 DLQSKFVAKENEVQSLHSKLTDTLVSKQ----QLEQRLMQLMESEQKRVNKEESLQMQVQ 572
Query: 231 RQYKEDESQSEEENDYRNLDASPTYKGLLMS-----LQNQLKESKSKIDALSSEKLNL-Q 284
+++E+ + + + A+ T +L + + K+ K D+L+SE+ L
Sbjct: 573 DILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 632
Query: 285 KDLETRPTQHELRLYKQQVKKLEK-ALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQAL 343
K+ E + Q+ L K +V+KL+ A ++ EL K + KD+ + ++Q
Sbjct: 633 KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL--EKMQQSVYVKDDKIRLLEEQLQ 690
Query: 344 ID----QRYFQVLCSINSIIHN--PRAPVIIYKQTKGGVQNFNKDLVQ--DCGFEHLVPV 395
+ F++L N + + + ++ +Q V + +Q D + + +
Sbjct: 691 HEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEEL 750
Query: 396 IEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKE 455
+E Q+ + ++ +++T ++ L + K +N+ + L+ + ++ E + K
Sbjct: 751 LETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI 810
Query: 456 K 456
K
Sbjct: 811 K 811
Score = 43.9 bits (102), Expect = 4e-04
Identities = 60/285 (21%), Positives = 113/285 (39%), Gaps = 19/285 (6%)
Query: 52 LKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQR 111
LKD + ++ + +R+ +E + + M+Q+ + + R + Q+E +E
Sbjct: 1018 LKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQ-QVEAVELEAKEVL 1076
Query: 112 ANDLEQIMESVKSKIGELED--ESLSRACHQ-----------QNKIKDLQKEQKTLQVKC 158
++ GE E ++ C ++K+K+ + LQ++C
Sbjct: 1077 KKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLEC 1136
Query: 159 QHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLID 218
+ YK E E + LQ V ++EE V + + + Q L +
Sbjct: 1137 EKYKSVLAETEGILQKLQRSV---EQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1193
Query: 219 YYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSS 278
I + +R++ E E + E + K LL LQ +L +S S+ +
Sbjct: 1194 SENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEA-VRQN 1252
Query: 279 EKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHK 323
E+LNL K + T +LR + + +K+ L K + ELI K
Sbjct: 1253 EELNLLK-AQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSK 1296
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 58.2 bits (139), Expect = 2e-08
Identities = 107/517 (20%), Positives = 224/517 (43%), Gaps = 69/517 (13%)
Query: 59 DKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQI 118
DKQ Q +L + + ++ ++++ N L+ E+Q Q+ A Q A++LE++
Sbjct: 613 DKQIKQT-EDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKM 671
Query: 119 MESV---KSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASL 175
+SV KI LE++ ++ + K L + K L+ + Q + +EQ
Sbjct: 672 QQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVE 731
Query: 176 QMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQ--Y 233
QME C +K+E+ + V + +L+ L+ + E ++ I T+
Sbjct: 732 QMEKCIQEKDEKLKTVEE--------------LLETGLI-QVATKEEELNAIRTENSSLT 776
Query: 234 KEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKI----DALSSEKLNL-QKDLE 288
KE + ++ND ++ L+ L+ + E KI + L +E L + K+
Sbjct: 777 KEVQDLKAKQND------QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKT 830
Query: 289 TRPTQHELRLYKQQV--KKLEKALKKNV--KLQELINHKKAEDTEKKDEPSKYNQQQALI 344
+ + E++ K+++ +LEKA + ++ K+QEL N K ++ + N +A++
Sbjct: 831 VQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKE-------EQMNTMKAVL 883
Query: 345 DQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLT 404
+++ + + + + + Q+ K+ FE L V++ ++
Sbjct: 884 EEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLK---EKEN 940
Query: 405 SLKDLYKSLKTLSAELVPWLNLKK--QDENEGIK--VEDLLFIVDTMLEEVENKEKDSNM 460
LK L LK ++L L + QDEN+ K +E L + +N ++ S+
Sbjct: 941 ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQL---------KQQNYQQASSF 991
Query: 461 PHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRLGEMNNAVRNLQELLELDSSSSLCV 520
P + L ++S +K ++G++ ++ + + +L+E + ++
Sbjct: 992 PPHEELLKVISEREK-----EISGLWNELDSLKDAVEHQRKKNNDLRE----KNWEAMEA 1042
Query: 521 LVSTVGKLCRLINEDVNEQVMQVLGPE-DLQSIIYKL 556
L ST L +N+ E+ QV E + + ++ KL
Sbjct: 1043 LASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKL 1079
Score = 54.7 bits (130), Expect = 2e-07
Identities = 92/481 (19%), Positives = 212/481 (44%), Gaps = 38/481 (7%)
Query: 4 VAPKPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDL-KDLIIFDKQS 62
+A +D++ DR Q+ E E NV++ + +L K ++ ++ I Q
Sbjct: 341 LAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE 400
Query: 63 SQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNEL-----QLEQSRAANQEQRANDLEQ 117
+Q+M+ + + E+ + I L + N LR+ + QLE ++A + D +
Sbjct: 401 TQQMQMKFQQVREQMEAE---IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYAR 457
Query: 118 IMESVKSKIGELEDESLSRACHQQ--NKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASL 175
++ + K G+L+ E + + +Q ++K +E + + Q Y +KRT + E A
Sbjct: 458 LVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEA-AQQ 516
Query: 176 QMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRK-----IHTQ 230
++ + KE E + + + K+ L+++L+ L++ + ++ K + Q
Sbjct: 517 DLQSKFVAKENEVQSLHSKLTDTLVSKQ----QLEQRLMQLMESEQKRVNKEESLQMQVQ 572
Query: 231 RQYKEDESQSEEENDYRNLDASPTYKGLLMS-----LQNQLKESKSKIDALSSEKLNL-Q 284
+++E+ + + + A+ T +L + + K+ K D+L+SE+ L
Sbjct: 573 DILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 632
Query: 285 KDLETRPTQHELRLYKQQVKKLEK-ALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQAL 343
K+ E + Q+ L K +V+KL+ A ++ EL K + KD+ + ++Q
Sbjct: 633 KEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL--EKMQQSVYVKDDKIRLLEEQLQ 690
Query: 344 ID----QRYFQVLCSINSIIHN--PRAPVIIYKQTKGGVQNFNKDLVQ--DCGFEHLVPV 395
+ F++L N + + + ++ +Q V + +Q D + + +
Sbjct: 691 HEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEEL 750
Query: 396 IEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKE 455
+E Q+ + ++ +++T ++ L + K +N+ + L+ + ++ E + K
Sbjct: 751 LETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI 810
Query: 456 K 456
K
Sbjct: 811 K 811
Score = 43.9 bits (102), Expect = 4e-04
Identities = 60/285 (21%), Positives = 113/285 (39%), Gaps = 19/285 (6%)
Query: 52 LKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQR 111
LKD + ++ + +R+ +E + + M+Q+ + + R + Q+E +E
Sbjct: 1018 LKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQ-QVEAVELEAKEVL 1076
Query: 112 ANDLEQIMESVKSKIGELED--ESLSRACHQ-----------QNKIKDLQKEQKTLQVKC 158
++ GE E ++ C ++K+K+ + LQ++C
Sbjct: 1077 KKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLEC 1136
Query: 159 QHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLID 218
+ YK E E + LQ V ++EE V + + + Q L +
Sbjct: 1137 EKYKSVLAETEGILQKLQRSV---EQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1193
Query: 219 YYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSS 278
I + +R++ E E + E + K LL LQ +L +S S+ +
Sbjct: 1194 SENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEA-VRQN 1252
Query: 279 EKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHK 323
E+LNL K + T +LR + + +K+ L K + ELI K
Sbjct: 1253 EELNLLK-AQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSK 1296
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 58.2 bits (139), Expect = 2e-08
Identities = 67/304 (22%), Positives = 141/304 (46%), Gaps = 54/304 (17%)
Query: 85 QELIETNQQLRNELQLEQSRAAN--------------------QEQ---RANDLEQIMES 121
+EL E N +L+ +LQL +S + Q+Q A+ L + ++S
Sbjct: 278 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 337
Query: 122 VKSKI-GELEDESLSRACHQQNKIKDLQKEQK--TLQVKCQHYKKKRTEQEETIASLQME 178
V +K+ ++E+ L +QQ + K ++E+K + K Q ++K EQEE I + +
Sbjct: 338 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK 397
Query: 179 VCRLKK---EEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIR----KIHTQR 231
+ R ++ E+E+++ Q + +++ R+ ++ E KIR K+H Q
Sbjct: 398 MRRQEEMMWEKEEKMRRQEEMMWEKEEKM------RRQEEMMWEKEEKIRELEEKMHEQE 451
Query: 232 QYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDA------LSSEKLNLQK 285
+ +E E + +EE R + + + + +++E + KI EK++ Q+
Sbjct: 452 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQE 511
Query: 286 DL---ETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQA 342
+ E R Q E+ ++++++ E+ ++ K+ E E+ +K E + Q++
Sbjct: 512 KIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHE------QEEKIRKQEEKMWRQEEK 565
Query: 343 LIDQ 346
+ DQ
Sbjct: 566 MHDQ 569
Score = 53.9 bits (128), Expect = 4e-07
Identities = 74/335 (22%), Positives = 147/335 (43%), Gaps = 49/335 (14%)
Query: 17 RLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEE 76
+L+ +QQ +AE + + L K + V+ +L + + ++Q ++M +
Sbjct: 316 KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL--NQQQEEKMWR-------- 365
Query: 77 TSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELED---ES 133
Q+ IQE E Q+ +++ ++ + QE++ E++M + K+ E+ E
Sbjct: 366 ---QEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK 422
Query: 134 LSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQ 193
+ Q+ + + +++ + L+ K H ++K EQEE K++EE++I Q
Sbjct: 423 EEKMRRQEEMMWEKEEKIRELEEK-MHEQEKIREQEE------------KRQEEEKIREQ 469
Query: 194 NRVFAYLCKRVPHTVLDRQLLCLIDYYESKI----RKIHTQRQYKEDESQSEEENDYRNL 249
+ K R+ I E K+ KIH Q + +E+E + E+E +R
Sbjct: 470 EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 529
Query: 250 DASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVK---KL 306
+ + Q ++ K KI EK+ Q E + + E +++ Q+ K +
Sbjct: 530 EK--------IREQEEIWRQKEKIHE-QEEKIRKQ---EEKMWRQEEKMHDQEEKIREQE 577
Query: 307 EKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQ 341
EK ++ K++E K E EK E + Q+Q
Sbjct: 578 EKVWRQEEKIREQ-EEKIREQEEKIREQEEMTQEQ 611
Score = 50.4 bits (119), Expect = 5e-06
Identities = 56/293 (19%), Positives = 134/293 (45%), Gaps = 45/293 (15%)
Query: 61 QSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRN--ELQLEQSRAANQEQRANDLEQI 118
+ ++MR+ +++ E+ + + + E +++R E EQ + QE++ + E+I
Sbjct: 407 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI 466
Query: 119 MESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQME 178
E E E ++ Q+ KI++ +++ + + K ++K EQE+ ++ E
Sbjct: 467 REQ------EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEK----IREE 516
Query: 179 VCRLKKEE----EDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYK 234
R ++EE E++I Q ++ K I E KIRK ++ ++
Sbjct: 517 EKRQEQEEMWRQEEKIREQEEIWRQKEK--------------IHEQEEKIRK-QEEKMWR 561
Query: 235 EDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQH 294
++E ++E R + + + +++E + KI EK+ Q+++ +
Sbjct: 562 QEEKMHDQEEKIREQEEK------VWRQEEKIREQEEKIRE-QEEKIREQEEM---TQEQ 611
Query: 295 ELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQR 347
E ++ +Q+ EK ++ K+QE + ++ + +++ K +Q+ I ++
Sbjct: 612 EEKMGEQE----EKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 660
Score = 47.4 bits (111), Expect = 4e-05
Identities = 30/134 (22%), Positives = 69/134 (51%), Gaps = 13/134 (9%)
Query: 60 KQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIM 119
KQ + RQ E+ Q+ I+E E + +++ ++ + QE++ + E++
Sbjct: 554 KQEEKMWRQE-----EKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMT 608
Query: 120 ESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEV 179
+ + K+GE E+ + C Q+ K+++ +++ + + K + +KK EQEE I +
Sbjct: 609 QEQEEKMGEQEE----KMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE--- 661
Query: 180 CRLKKEEEDRIVTQ 193
+ +E+E+++ Q
Sbjct: 662 -EMMQEQEEKMWEQ 674
Score = 40.8 bits (94), Expect = 0.004
Identities = 22/103 (21%), Positives = 55/103 (53%), Gaps = 5/103 (4%)
Query: 75 EETSCQQN-MIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDES 133
EE C+Q +QE E ++ +++ ++ + QE++ + E++M+ + K+ E E+
Sbjct: 619 EEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE-- 676
Query: 134 LSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQ 176
+ C Q+ K+++ +++ + + K + + +QEE + Q
Sbjct: 677 --KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 717
Score = 40.0 bits (92), Expect = 0.006
Identities = 31/151 (20%), Positives = 69/151 (45%), Gaps = 15/151 (9%)
Query: 48 KRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAAN 107
K D ++ I ++ R + ++ E+ Q+ I+E E Q+ ++ ++ +
Sbjct: 565 KMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCE 624
Query: 108 QEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTE 167
QE++ + E+ M + KI E E + Q+ KI++ ++ + + K ++K E
Sbjct: 625 QEEKMQEQEEKMRRQEEKIREQE----KKIREQEEKIREQEEMMQEQEEKMWEQEEKMCE 680
Query: 168 QEETIASLQMEV-----------CRLKKEEE 187
QEE + + ++ RL+++EE
Sbjct: 681 QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 711
>gi|239741279 PREDICTED: similar to FLJ00310 protein [Homo sapiens]
Length = 561
Score = 58.2 bits (139), Expect = 2e-08
Identities = 71/363 (19%), Positives = 157/363 (43%), Gaps = 42/363 (11%)
Query: 43 PLSLVKRTDLKDLIIFDKQSSQRMR--------QNLKLLVEETSCQQNMIQELIETNQQL 94
P L K D ++L +KQ + + Q+L + ++ T N I + + +Q+
Sbjct: 219 PKKLKKEHDREELERKEKQYKKEVEAKQLEPTVQSLDMKLKTTRNTPNQINQSLRYSQKK 278
Query: 95 RNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTL 154
+ + + +Q+ +++++ E+ ++K+ + S + + +I LQ E +
Sbjct: 279 VIGFRNSPNDLSQTQQQIKEMKEMYENAEAKV----NNSTGKWSCVEERICQLQHENPCI 334
Query: 155 QVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLL 214
+ + +K + +E + ++Q K++ + +N+ C + +
Sbjct: 335 EQQLDDVHQKE-DHKEIVTNIQRGFIESGKKDL-MLEEKNKKLMNECDHLKES------- 385
Query: 215 CLIDYYESKIRKIHTQRQYKED-----------ESQSEEENDYR-NLDASPTYKGLLMSL 262
L Y K ++ RQ +++ ES E + Y NLD + K L +
Sbjct: 386 -LFQYEREKAERVVVVRQLQQEAADSLKKLTMLESPLEGISHYHINLDETQVPKKKLFQV 444
Query: 263 QNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINH 322
++Q + ++ +A+SS+ +NL K+++ Q EL K+ ++ EK + L+E I +
Sbjct: 445 ESQFDDFMAEKEAVSSKCVNLAKEIQV--FQQELLSMKKVQQECEKLEEDKKMLEEEILN 502
Query: 323 KKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKD 382
K E SK + ++ +D+R Q + + I +A + K ++ NKD
Sbjct: 503 LKTHMENSMVELSKLQEYKSELDERAMQAVEKLEEIHLQEQA------EHKKQLEQLNKD 556
Query: 383 LVQ 385
++Q
Sbjct: 557 IIQ 559
>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
sapiens]
Length = 1591
Score = 57.4 bits (137), Expect = 4e-08
Identities = 93/399 (23%), Positives = 167/399 (41%), Gaps = 53/399 (13%)
Query: 61 QSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQ--LEQSRAANQEQRANDLEQI 118
Q ++ Q LKL V + S + ++ + + +E++ LE+SRA +E + LEQ
Sbjct: 1037 QEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQE 1096
Query: 119 MESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQME 178
E+++++I +L + + Q + +L+ + +C R E+E I
Sbjct: 1097 TENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNI------ 1150
Query: 179 VCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDES 238
LK E N+ F L Q++ L +S++ + Q+ K +
Sbjct: 1151 ---LKAELNKVTSLHNQAFEI------EKNLKEQIIELQSKLDSELSALERQKDEKITQQ 1201
Query: 239 QSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRL 298
+ + E +NL+ + L+S Q Q +E +KLN +KD + E +L
Sbjct: 1202 EEKYEAIIQNLEKD---RQKLVSSQEQDREQ-------LIQKLNCEKDEAIQTALKEFKL 1251
Query: 299 YKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSI--- 355
++ V+K + L+K L+ I A D+ + D S + Q + + + L +
Sbjct: 1252 EREVVEK--ELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQ 1309
Query: 356 ----NSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSL----- 406
N + N R +I +QT NFN L ++ + +I +D+L S
Sbjct: 1310 EKRKNEEMQNVRTSLIAEQQT-----NFNTVLTREKMRKE--NIINDLSDKLKSTMQQQE 1362
Query: 407 --KDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFI 443
KDL +SL A L L KK+ E E K+ F+
Sbjct: 1363 RDKDLIESLSEDRARL---LEEKKKLEEEVSKLRSSSFV 1398
Score = 42.4 bits (98), Expect = 0.001
Identities = 114/520 (21%), Positives = 200/520 (38%), Gaps = 89/520 (17%)
Query: 84 IQELIETNQQLRNELQLEQSRAANQEQ-RANDLEQIMESVKSKIG-----ELEDESLSRA 137
IQ + E R +Q EQ +N + A ++ I+E VK + + + E LS
Sbjct: 812 IQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLK 871
Query: 138 CHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVF 197
+ K+ L KE + + K + K + EE + + E +K E+E I QN
Sbjct: 872 NEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNE-- 929
Query: 198 AYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKG 257
D++LL + + S+ +I +Q +E + ++ N + +
Sbjct: 930 -----------KDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRA 978
Query: 258 LLMSL-QNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKL 316
L SL Q+ LKE L+ L+ R Q ++ LE+ K+N
Sbjct: 979 ELQSLEQSHLKE--------------LEDTLQVRHIQEFEKVMTDHRVSLEELKKEN--- 1021
Query: 317 QELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGV 376
Q++IN + E E K Q+ L C + V
Sbjct: 1022 QQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLE-------------------V 1062
Query: 377 QNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIK 436
+ K+ D E + + E A Q +LK L + + LN K QD NE +
Sbjct: 1063 ELALKEAETD---EIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQ 1119
Query: 437 VEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRL 496
V L + EKD Q + ++S ++ N + +N+V +
Sbjct: 1120 VG------LAELRTLMTIEKD------QCISELISRHEE-----ESNILKAELNKVTSLH 1162
Query: 497 GEMNNAVRNLQE-LLELDSSSSLCVLVSTVGKLCRLINEDVNEQVMQVLGPEDLQSIIYK 555
+ +NL+E ++EL S L S + L R +E + +Q E ++II
Sbjct: 1163 NQAFEIEKNLKEQIIELQSK-----LDSELSALERQKDEKITQQ------EEKYEAIIQN 1211
Query: 556 LE-EHEEFFPAFQAFTNDLLEILEIDDLDAIVPAVKKLKV 594
LE + ++ + + L++ L + +AI A+K+ K+
Sbjct: 1212 LEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKL 1251
>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
sapiens]
Length = 1594
Score = 57.4 bits (137), Expect = 4e-08
Identities = 93/399 (23%), Positives = 167/399 (41%), Gaps = 53/399 (13%)
Query: 61 QSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQ--LEQSRAANQEQRANDLEQI 118
Q ++ Q LKL V + S + ++ + + +E++ LE+SRA +E + LEQ
Sbjct: 1037 QEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQE 1096
Query: 119 MESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQME 178
E+++++I +L + + Q + +L+ + +C R E+E I
Sbjct: 1097 TENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNI------ 1150
Query: 179 VCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDES 238
LK E N+ F L Q++ L +S++ + Q+ K +
Sbjct: 1151 ---LKAELNKVTSLHNQAFEI------EKNLKEQIIELQSKLDSELSALERQKDEKITQQ 1201
Query: 239 QSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRL 298
+ + E +NL+ + L+S Q Q +E +KLN +KD + E +L
Sbjct: 1202 EEKYEAIIQNLEKD---RQKLVSSQEQDREQ-------LIQKLNCEKDEAIQTALKEFKL 1251
Query: 299 YKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSI--- 355
++ V+K + L+K L+ I A D+ + D S + Q + + + L +
Sbjct: 1252 EREVVEK--ELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQ 1309
Query: 356 ----NSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSL----- 406
N + N R +I +QT NFN L ++ + +I +D+L S
Sbjct: 1310 EKRKNEEMQNVRTSLIAEQQT-----NFNTVLTREKMRKE--NIINDLSDKLKSTMQQQE 1362
Query: 407 --KDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFI 443
KDL +SL A L L KK+ E E K+ F+
Sbjct: 1363 RDKDLIESLSEDRARL---LEEKKKLEEEVSKLRSSSFV 1398
Score = 42.4 bits (98), Expect = 0.001
Identities = 114/520 (21%), Positives = 200/520 (38%), Gaps = 89/520 (17%)
Query: 84 IQELIETNQQLRNELQLEQSRAANQEQ-RANDLEQIMESVKSKIG-----ELEDESLSRA 137
IQ + E R +Q EQ +N + A ++ I+E VK + + + E LS
Sbjct: 812 IQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLK 871
Query: 138 CHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVF 197
+ K+ L KE + + K + K + EE + + E +K E+E I QN
Sbjct: 872 NEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNE-- 929
Query: 198 AYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKG 257
D++LL + + S+ +I +Q +E + ++ N + +
Sbjct: 930 -----------KDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRA 978
Query: 258 LLMSL-QNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKL 316
L SL Q+ LKE L+ L+ R Q ++ LE+ K+N
Sbjct: 979 ELQSLEQSHLKE--------------LEDTLQVRHIQEFEKVMTDHRVSLEELKKEN--- 1021
Query: 317 QELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGV 376
Q++IN + E E K Q+ L C + V
Sbjct: 1022 QQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLE-------------------V 1062
Query: 377 QNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIK 436
+ K+ D E + + E A Q +LK L + + LN K QD NE +
Sbjct: 1063 ELALKEAETD---EIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQ 1119
Query: 437 VEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRL 496
V L + EKD Q + ++S ++ N + +N+V +
Sbjct: 1120 VG------LAELRTLMTIEKD------QCISELISRHEE-----ESNILKAELNKVTSLH 1162
Query: 497 GEMNNAVRNLQE-LLELDSSSSLCVLVSTVGKLCRLINEDVNEQVMQVLGPEDLQSIIYK 555
+ +NL+E ++EL S L S + L R +E + +Q E ++II
Sbjct: 1163 NQAFEIEKNLKEQIIELQSK-----LDSELSALERQKDEKITQQ------EEKYEAIIQN 1211
Query: 556 LE-EHEEFFPAFQAFTNDLLEILEIDDLDAIVPAVKKLKV 594
LE + ++ + + L++ L + +AI A+K+ K+
Sbjct: 1212 LEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKL 1251
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 57.4 bits (137), Expect = 4e-08
Identities = 76/326 (23%), Positives = 142/326 (43%), Gaps = 52/326 (15%)
Query: 48 KRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAAN 107
+R DL++ + + + Q +Q L + + +Q+ E QL + L+ + + +
Sbjct: 661 QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLS 720
Query: 108 QEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQK---TLQVKCQHYKKK 164
EQ+ +LE +I +LE +SL ++ ++DLQ++++ L+++ K+
Sbjct: 721 LEQKTEELE-------GQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ 773
Query: 165 RTEQEETIASLQMEVCR------------LKKEEEDRIVTQN---------RVFAYLCKR 203
++E ++S ++++ + K+EEE +I+ Q+ L R
Sbjct: 774 LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
Query: 204 VPHTVLDRQ--------LLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRN---LDAS 252
+ TV + Q L+ + + K+ K+ K +S+ E+EN LD
Sbjct: 834 IQTTVTELQKVKMEKEALMTELSTVKDKLSKV--SDSLKNSKSEFEKENQKGKAAILDLE 891
Query: 253 PTYKGLLMSLQ----NQLKESKSKIDALSSEK-LNLQKDLETRPTQHELRLYKQQVKKLE 307
T K L LQ N LKE K +L EK + Q LE Q +L + +K+ E
Sbjct: 892 KTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNE 951
Query: 308 KALKKNVKLQELINHKKAEDTEKKDE 333
K+ +LQ IN K +KK +
Sbjct: 952 ---KEEQQLQGNINELKQSSEQKKKQ 974
Score = 55.8 bits (133), Expect = 1e-07
Identities = 85/361 (23%), Positives = 150/361 (41%), Gaps = 53/361 (14%)
Query: 21 EKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDL-IIFDKQSSQR--MRQNLKLLVEET 77
E+Q EEA+ E+ N+ M + + T++ D+ +D++ S R Q + L EE
Sbjct: 141 EQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEEL 200
Query: 78 SCQQNMIQEL---------IETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGE 128
+ + +IQ+L IE L+ EL Q+ N + E+ E +K + +
Sbjct: 201 NKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNM---TLERERESEKLKDECKK 257
Query: 129 LEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEED 188
L+ + S +L K + + V Q +K ++ E Q L K+E+D
Sbjct: 258 LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD 317
Query: 189 --RIVTQNRVFAYLCKRVPHTVLDRQLLC-----LIDYYESKIRKIHTQRQYKEDESQ-- 239
++ ++ + K + T+ + L C + E+ + +IH + K + +Q
Sbjct: 318 YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKL 377
Query: 240 ----SEEENDYRNLDASPTYKGLLMSLQNQLKES-------KSKIDALSSEKLNLQKDL- 287
SE E Y++L A LQ Q +E +S+I+ L S+ L ++ L
Sbjct: 378 KEELSEVETKYQHLKAE------FKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLG 431
Query: 288 -------ETRPTQHELRLYK-QQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQ 339
E R E + K QQV L+ L +L+E + K TE + + K Q
Sbjct: 432 EAHGRLKEQRQLSSEKLMDKEQQVADLQLKLS---RLEEQLKEKVTNSTELQHQLDKTKQ 488
Query: 340 Q 340
Q
Sbjct: 489 Q 489
Score = 51.6 bits (122), Expect = 2e-06
Identities = 61/281 (21%), Positives = 123/281 (43%), Gaps = 17/281 (6%)
Query: 73 LVEETSCQQNMIQELIETN---QQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGEL 129
L E+ Q + +EL E Q L+ E + Q + +EQ L+ + + SK+ E
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET 426
Query: 130 E---DESLSRACHQQN----KIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRL 182
E E+ R Q+ K+ D +++ LQ+K +++ E+ LQ ++ +
Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486
Query: 183 KKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDE---SQ 239
K++ +++ Q A L R L+ Q+L I + KI+ + Q ++ +
Sbjct: 487 KQQHQEQQALQQSTTAKL--REAQNDLE-QVLRQIGDKDQKIQNLEALLQKSKENISLLE 543
Query: 240 SEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLY 299
E E+ Y + A +L LQ + + ++ L +EKL Q + + ++
Sbjct: 544 KEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQL-TEKLKNQSESHKQAQENLHDQV 602
Query: 300 KQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQ 340
++Q L A + + L+ +N ++ E K++ S+ + Q
Sbjct: 603 QEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQ 643
Score = 47.0 bits (110), Expect = 5e-05
Identities = 65/302 (21%), Positives = 131/302 (43%), Gaps = 21/302 (6%)
Query: 45 SLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNEL-QLEQS 103
+L ++ +LK + +K++S +++ L + E+ QN +++ + QQL+ + +L+QS
Sbjct: 908 TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967
Query: 104 RAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQ--NKIKDLQKEQKTLQVKCQHY 161
EQ+ +E + + KI L+ L QQ ++L E++ + V +Y
Sbjct: 968 ----SEQKKKQIEALQGEL--KIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNY 1021
Query: 162 KKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYE 221
+K +ET LQ + + E V L + +R I
Sbjct: 1022 EK----SQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRN---QIGNQN 1074
Query: 222 SKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKL 281
I+++ T + E +S +E+ A + + +L KSK+ + E++
Sbjct: 1075 KLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEI--EEI 1132
Query: 282 NLQKDLETRPTQHELRLYK-QQVKKLE--KALKKNVKLQELINHKKAEDTEKKDEPSKYN 338
+++ E EL+ +K + +K++ K K+ + Q+L KA+ + E K N
Sbjct: 1133 KCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRN 1192
Query: 339 QQ 340
QQ
Sbjct: 1193 QQ 1194
Score = 44.7 bits (104), Expect = 2e-04
Identities = 76/325 (23%), Positives = 140/325 (43%), Gaps = 63/325 (19%)
Query: 22 KQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQ 81
KQ E + + I L G ++++++T+L++ + +Q + Q L E+ S Q
Sbjct: 965 KQSSEQKKKQIEAL---QGELKIAVLQKTELENKL---QQQLTQAAQELAAEKEKISVLQ 1018
Query: 82 NMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACH-- 139
N ++ ET +QL+++ +E Q ++SV+ K+ +++ +S
Sbjct: 1019 NNYEKSQETFKQLQSDFY-------GRESELLATRQDLKSVEEKLSLAQEDLISNRNQIG 1071
Query: 140 QQNK-IKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFA 198
QNK I++L+ + TL+ Q KK + +E +LQ ++ + K +E +V + A
Sbjct: 1072 NQNKLIQELKTAKATLE---QDSAKKEQQLQERCKALQ-DIQKEKSLKEKELVNEKSKLA 1127
Query: 199 YLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGL 258
+ ++ C E +I K++ + + + ES E N K
Sbjct: 1128 EI----------EEIKCR---QEKEITKLNEELKSHKLESIKEITN----------LKDA 1164
Query: 259 LMSLQNQLKESKSKIDALSS----EKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNV 314
L Q E + K D+L + EK N Q + K QVKK E+ LKK
Sbjct: 1165 KQLLIQQKLELQGKADSLKAAVEQEKRNQQ-------------ILKDQVKKEEEELKKEF 1211
Query: 315 KLQELINHKKAEDTE---KKDEPSK 336
+E H + ++ E KK E ++
Sbjct: 1212 IEKEAKLHSEIKEKEVGMKKHEENE 1236
Score = 31.2 bits (69), Expect = 2.8
Identities = 35/168 (20%), Positives = 70/168 (41%), Gaps = 28/168 (16%)
Query: 22 KQQEEAEWESINVLLMMHGLKPLS-LVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQ 80
K ++E E +N L H L+ + + D K L+I K Q +LK VE+
Sbjct: 1133 KCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRN 1192
Query: 81 QNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQ 140
Q ++++ ++ ++ EL+ E +E E++++ + H+
Sbjct: 1193 QQILKDQVKKEEE---ELKKE----------------FIEKEAKLHSEIKEKEVGMKKHE 1233
Query: 141 QNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEED 188
+N+ K T+Q+ + ++E S Q V L+K+ +D
Sbjct: 1234 ENEAK------LTMQITALNENLGTVKKEWQ--SSQRRVSELEKQTDD 1273
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 57.4 bits (137), Expect = 4e-08
Identities = 105/490 (21%), Positives = 208/490 (42%), Gaps = 59/490 (12%)
Query: 41 LKPLSLVKRTD-----LKDLIIFDKQSSQRMRQNLKLLVEETSC---QQNMIQELIETNQ 92
+KPL V R + +D + K+ Q+ LK L ++ S ++N++QE ++
Sbjct: 841 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900
Query: 93 QLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQK 152
+L E + + R A ++Q +LE+I+ +++++ E ED + LQ E+K
Sbjct: 901 ELYAEAEEMRVRLAAKKQ---ELEEILHEMEARLEEEEDRG-----------QQLQAERK 946
Query: 153 TLQVKCQHYKKKRTEQEETIASLQME----VCRLKKEEEDRIV--TQNRVFAYLCKRVPH 206
+ + +++ E+E LQ+E ++KK E++ +V QN + K +
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 207 TVLD------------RQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPT 254
+ D + L L + +ES I ++ R KE++S+ E E R L+ +
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV-RLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 255 -YKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKN 313
+ + LQ Q+ E K ++ A E+L Q L ++ + ALKK
Sbjct: 1066 DFHEQIADLQAQIAELKMQL-AKKEEEL-----------QAALARLDDEIAQKNNALKKI 1113
Query: 314 VKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTK 373
+L+ I+ + + ++ +K +Q+ + + + + + + + + +
Sbjct: 1114 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1173
Query: 374 GGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENE 433
V K L ++ H V EM ++++L + L+ K+ E E
Sbjct: 1174 QEVTVLKKALDEETR-SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 434 GIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNG-VYPRMNEV 492
+ L ++ +EVE+K+K Q LQ+ S ++ LN V+ NEV
Sbjct: 1233 NADLAGELRVLGQAKQEVEHKKKKLE-AQVQELQSKCSDGERA--RAELNDKVHKLQNEV 1289
Query: 493 YTRLGEMNNA 502
+ G +N A
Sbjct: 1290 ESVTGMLNEA 1299
Score = 46.6 bits (109), Expect = 7e-05
Identities = 62/293 (21%), Positives = 124/293 (42%), Gaps = 42/293 (14%)
Query: 64 QRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVK 123
Q MRQ VEE + Q Q R + L++++ +++ A+ +
Sbjct: 1195 QEMRQKHAQAVEELTEQ---------LEQFKRAKANLDKNKQTLEKENAD-----LAGEL 1240
Query: 124 SKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQME---VC 180
+G+ + E ++K K L+ + + LQ KC ++ R E + + LQ E V
Sbjct: 1241 RVLGQAKQE-------VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293
Query: 181 RLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQS 240
+ E E + + + A L ++ T ++L L + K+ RQ +E+ +
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDT---QEL--LQEETRQKLNVSTKLRQLEEERNSL 1348
Query: 241 EEENDYRNLDASPTYKGLLMSLQNQLKESKSK-------IDALSSEKLNLQKDLETRPTQ 293
+++ D ++A + + +L QL +SK K ++AL K QK++E Q
Sbjct: 1349 QDQLD-EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1407
Query: 294 HELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQ 346
Y+++ +K K +LQ+ ++ + ++ S ++Q DQ
Sbjct: 1408 -----YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Score = 40.0 bits (92), Expect = 0.006
Identities = 64/276 (23%), Positives = 123/276 (44%), Gaps = 30/276 (10%)
Query: 85 QELIETNQQLRNELQ-LEQSR------AANQEQRANDLEQIMESVKSKIGELEDESLSRA 137
+EL TN+ L+ E++ L S+ E+ LE ME +K+++ ELEDE +
Sbjct: 1500 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT- 1558
Query: 138 CHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQ-EETIASLQMEVCRLKKEEEDRIVTQNRV 196
+ K++ L+ + L+ + + + R EQ EE LQ ++ + E ED Q +
Sbjct: 1559 --EDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE-RKQRAL 1614
Query: 197 FAYLCKRVPHTVLDRQLLC--LIDYYESKIRKIH-TQRQYKEDESQSEEENDYR------ 247
A K++ + D +L I E I+++ Q Q K+ + + E+ R
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 248 ---NLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLET-----RPTQHELRLY 299
N + + + LM LQ L ++ EK L ++L + Q E R
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 300 KQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPS 335
+ ++ +LE+ L++ E ++ + + T++ ++ S
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770
Score = 37.4 bits (85), Expect = 0.040
Identities = 64/301 (21%), Positives = 119/301 (39%), Gaps = 22/301 (7%)
Query: 53 KDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRA 112
+DL D+Q+ ++ RQ + ++L E +L +E + AA +++
Sbjct: 1578 RDLQARDEQNEEKRRQ--------------LQRQLHEYETELEDERKQRALAAAAKKKLE 1623
Query: 113 NDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETI 172
DL+ + S I E E++ + Q ++KD Q+E + + E E+
Sbjct: 1624 GDLKDLELQADSAIKGRE-EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1682
Query: 173 ASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQ 232
SL+ ++ +L +E+ + R A L K L L + K R++ +
Sbjct: 1683 KSLEADLMQL--QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK-RRLEARIA 1739
Query: 233 YKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQK-DLETRP 291
E+E + E+ N D L N+L +S S + L++ + E R
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 292 TQHELR-LYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQ 350
HE+ K + K AL+ K+ +L + E EK+ Q+ + + Q
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALE--AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 351 V 351
V
Sbjct: 1858 V 1858
Score = 36.6 bits (83), Expect = 0.067
Identities = 50/243 (20%), Positives = 100/243 (41%), Gaps = 50/243 (20%)
Query: 60 KQSSQRMRQNLKLLVEETSCQQ-------NMIQELIETNQQLRNELQLEQSRAANQEQRA 112
+ +R+ + L EE +Q + +++ + +QL NEL E+S A E
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1787
Query: 113 NDLEQ----------------------IMESVKSKIGELEDESLSRACHQQNKIKDLQKE 150
LE+ + ++++KI +LE++ A +Q K L+++
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847
Query: 151 QKTLQ---VKCQHYKKKRTEQEETIASLQMEVCRLKK-----EEEDRIVTQNRVFAYLCK 202
K L+ ++ + +K + +E V +LK+ EEE + + NR L +
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR--RKLQR 1905
Query: 203 RVPHTVLDRQLLCL-IDYYESKIRKIHTQ----------RQYKEDESQSEEENDYRNLDA 251
+ + + ++ +SK+R+ + R+ E+ SEEE D R+ D
Sbjct: 1906 ELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADF 1965
Query: 252 SPT 254
+ T
Sbjct: 1966 NGT 1968
Score = 32.3 bits (72), Expect = 1.3
Identities = 47/244 (19%), Positives = 96/244 (39%), Gaps = 32/244 (13%)
Query: 98 LQLEQSRAANQEQRAN---DLEQIMESVKSKIG---ELEDESLSRACHQQNKIKDLQKEQ 151
+QL++ AA + R + E++ E + S + L+DE ++L++EQ
Sbjct: 1690 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ 1749
Query: 152 KTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDR--IVTQNRVFAYLCKRVPHTVL 209
++ +K + E+ L E +K E R + QN+ + V
Sbjct: 1750 GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK 1809
Query: 210 DRQLLCLIDYYESKIRKIHTQ-------------------RQYKEDESQSEEENDYRNLD 250
+ I E+KI ++ Q ++ KE Q E+E
Sbjct: 1810 SK-FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868
Query: 251 ASPTYKG--LLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEK 308
KG + L+ QL+E++ + +++ + LQ++L+ +E ++V L+
Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE--AMGREVNALKS 1926
Query: 309 ALKK 312
L++
Sbjct: 1927 KLRR 1930
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 57.4 bits (137), Expect = 4e-08
Identities = 105/490 (21%), Positives = 208/490 (42%), Gaps = 59/490 (12%)
Query: 41 LKPLSLVKRTD-----LKDLIIFDKQSSQRMRQNLKLLVEETSC---QQNMIQELIETNQ 92
+KPL V R + +D + K+ Q+ LK L ++ S ++N++QE ++
Sbjct: 848 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 93 QLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQK 152
+L E + + R A ++Q +LE+I+ +++++ E ED + LQ E+K
Sbjct: 908 ELYAEAEEMRVRLAAKKQ---ELEEILHEMEARLEEEEDRG-----------QQLQAERK 953
Query: 153 TLQVKCQHYKKKRTEQEETIASLQME----VCRLKKEEEDRIV--TQNRVFAYLCKRVPH 206
+ + +++ E+E LQ+E ++KK E++ +V QN + K +
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 207 TVLD------------RQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPT 254
+ D + L L + +ES I ++ R KE++S+ E E R L+ +
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV-RLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 255 -YKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKN 313
+ + LQ Q+ E K ++ A E+L Q L ++ + ALKK
Sbjct: 1073 DFHEQIADLQAQIAELKMQL-AKKEEEL-----------QAALARLDDEIAQKNNALKKI 1120
Query: 314 VKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTK 373
+L+ I+ + + ++ +K +Q+ + + + + + + + + +
Sbjct: 1121 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1180
Query: 374 GGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENE 433
V K L ++ H V EM ++++L + L+ K+ E E
Sbjct: 1181 QEVTVLKKALDEETR-SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 434 GIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNG-VYPRMNEV 492
+ L ++ +EVE+K+K Q LQ+ S ++ LN V+ NEV
Sbjct: 1240 NADLAGELRVLGQAKQEVEHKKKKLE-AQVQELQSKCSDGERA--RAELNDKVHKLQNEV 1296
Query: 493 YTRLGEMNNA 502
+ G +N A
Sbjct: 1297 ESVTGMLNEA 1306
Score = 46.6 bits (109), Expect = 7e-05
Identities = 62/293 (21%), Positives = 124/293 (42%), Gaps = 42/293 (14%)
Query: 64 QRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVK 123
Q MRQ VEE + Q Q R + L++++ +++ A+ +
Sbjct: 1202 QEMRQKHAQAVEELTEQ---------LEQFKRAKANLDKNKQTLEKENAD-----LAGEL 1247
Query: 124 SKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQME---VC 180
+G+ + E ++K K L+ + + LQ KC ++ R E + + LQ E V
Sbjct: 1248 RVLGQAKQE-------VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300
Query: 181 RLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQS 240
+ E E + + + A L ++ T ++L L + K+ RQ +E+ +
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDT---QEL--LQEETRQKLNVSTKLRQLEEERNSL 1355
Query: 241 EEENDYRNLDASPTYKGLLMSLQNQLKESKSK-------IDALSSEKLNLQKDLETRPTQ 293
+++ D ++A + + +L QL +SK K ++AL K QK++E Q
Sbjct: 1356 QDQLD-EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1414
Query: 294 HELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQ 346
Y+++ +K K +LQ+ ++ + ++ S ++Q DQ
Sbjct: 1415 -----YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Score = 40.0 bits (92), Expect = 0.006
Identities = 64/276 (23%), Positives = 123/276 (44%), Gaps = 30/276 (10%)
Query: 85 QELIETNQQLRNELQ-LEQSR------AANQEQRANDLEQIMESVKSKIGELEDESLSRA 137
+EL TN+ L+ E++ L S+ E+ LE ME +K+++ ELEDE +
Sbjct: 1507 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT- 1565
Query: 138 CHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQ-EETIASLQMEVCRLKKEEEDRIVTQNRV 196
+ K++ L+ + L+ + + + R EQ EE LQ ++ + E ED Q +
Sbjct: 1566 --EDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE-RKQRAL 1621
Query: 197 FAYLCKRVPHTVLDRQLLC--LIDYYESKIRKIH-TQRQYKEDESQSEEENDYR------ 247
A K++ + D +L I E I+++ Q Q K+ + + E+ R
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 248 ---NLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLET-----RPTQHELRLY 299
N + + + LM LQ L ++ EK L ++L + Q E R
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 300 KQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPS 335
+ ++ +LE+ L++ E ++ + + T++ ++ S
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777
Score = 37.4 bits (85), Expect = 0.040
Identities = 64/301 (21%), Positives = 119/301 (39%), Gaps = 22/301 (7%)
Query: 53 KDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRA 112
+DL D+Q+ ++ RQ + ++L E +L +E + AA +++
Sbjct: 1585 RDLQARDEQNEEKRRQ--------------LQRQLHEYETELEDERKQRALAAAAKKKLE 1630
Query: 113 NDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETI 172
DL+ + S I E E++ + Q ++KD Q+E + + E E+
Sbjct: 1631 GDLKDLELQADSAIKGRE-EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1689
Query: 173 ASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQ 232
SL+ ++ +L +E+ + R A L K L L + K R++ +
Sbjct: 1690 KSLEADLMQL--QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK-RRLEARIA 1746
Query: 233 YKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQK-DLETRP 291
E+E + E+ N D L N+L +S S + L++ + E R
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 292 TQHELR-LYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQ 350
HE+ K + K AL+ K+ +L + E EK+ Q+ + + Q
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALE--AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 351 V 351
V
Sbjct: 1865 V 1865
Score = 36.6 bits (83), Expect = 0.067
Identities = 50/243 (20%), Positives = 100/243 (41%), Gaps = 50/243 (20%)
Query: 60 KQSSQRMRQNLKLLVEETSCQQ-------NMIQELIETNQQLRNELQLEQSRAANQEQRA 112
+ +R+ + L EE +Q + +++ + +QL NEL E+S A E
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794
Query: 113 NDLEQ----------------------IMESVKSKIGELEDESLSRACHQQNKIKDLQKE 150
LE+ + ++++KI +LE++ A +Q K L+++
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Query: 151 QKTLQ---VKCQHYKKKRTEQEETIASLQMEVCRLKK-----EEEDRIVTQNRVFAYLCK 202
K L+ ++ + +K + +E V +LK+ EEE + + NR L +
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR--RKLQR 1912
Query: 203 RVPHTVLDRQLLCL-IDYYESKIRKIHTQ----------RQYKEDESQSEEENDYRNLDA 251
+ + + ++ +SK+R+ + R+ E+ SEEE D R+ D
Sbjct: 1913 ELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADF 1972
Query: 252 SPT 254
+ T
Sbjct: 1973 NGT 1975
Score = 32.3 bits (72), Expect = 1.3
Identities = 47/244 (19%), Positives = 96/244 (39%), Gaps = 32/244 (13%)
Query: 98 LQLEQSRAANQEQRAN---DLEQIMESVKSKIG---ELEDESLSRACHQQNKIKDLQKEQ 151
+QL++ AA + R + E++ E + S + L+DE ++L++EQ
Sbjct: 1697 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ 1756
Query: 152 KTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDR--IVTQNRVFAYLCKRVPHTVL 209
++ +K + E+ L E +K E R + QN+ + V
Sbjct: 1757 GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK 1816
Query: 210 DRQLLCLIDYYESKIRKIHTQ-------------------RQYKEDESQSEEENDYRNLD 250
+ I E+KI ++ Q ++ KE Q E+E
Sbjct: 1817 SK-FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875
Query: 251 ASPTYKG--LLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEK 308
KG + L+ QL+E++ + +++ + LQ++L+ +E ++V L+
Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE--AMGREVNALKS 1933
Query: 309 ALKK 312
L++
Sbjct: 1934 KLRR 1937
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 57.4 bits (137), Expect = 4e-08
Identities = 105/490 (21%), Positives = 208/490 (42%), Gaps = 59/490 (12%)
Query: 41 LKPLSLVKRTD-----LKDLIIFDKQSSQRMRQNLKLLVEETSC---QQNMIQELIETNQ 92
+KPL V R + +D + K+ Q+ LK L ++ S ++N++QE ++
Sbjct: 848 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 93 QLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQK 152
+L E + + R A ++Q +LE+I+ +++++ E ED + LQ E+K
Sbjct: 908 ELYAEAEEMRVRLAAKKQ---ELEEILHEMEARLEEEEDRG-----------QQLQAERK 953
Query: 153 TLQVKCQHYKKKRTEQEETIASLQME----VCRLKKEEEDRIV--TQNRVFAYLCKRVPH 206
+ + +++ E+E LQ+E ++KK E++ +V QN + K +
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 207 TVLD------------RQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPT 254
+ D + L L + +ES I ++ R KE++S+ E E R L+ +
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV-RLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 255 -YKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKN 313
+ + LQ Q+ E K ++ A E+L Q L ++ + ALKK
Sbjct: 1073 DFHEQIADLQAQIAELKMQL-AKKEEEL-----------QAALARLDDEIAQKNNALKKI 1120
Query: 314 VKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTK 373
+L+ I+ + + ++ +K +Q+ + + + + + + + + +
Sbjct: 1121 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1180
Query: 374 GGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENE 433
V K L ++ H V EM ++++L + L+ K+ E E
Sbjct: 1181 QEVTVLKKALDEETR-SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 434 GIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNG-VYPRMNEV 492
+ L ++ +EVE+K+K Q LQ+ S ++ LN V+ NEV
Sbjct: 1240 NADLAGELRVLGQAKQEVEHKKKKLE-AQVQELQSKCSDGERA--RAELNDKVHKLQNEV 1296
Query: 493 YTRLGEMNNA 502
+ G +N A
Sbjct: 1297 ESVTGMLNEA 1306
Score = 46.6 bits (109), Expect = 7e-05
Identities = 62/293 (21%), Positives = 124/293 (42%), Gaps = 42/293 (14%)
Query: 64 QRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVK 123
Q MRQ VEE + Q Q R + L++++ +++ A+ +
Sbjct: 1202 QEMRQKHAQAVEELTEQ---------LEQFKRAKANLDKNKQTLEKENAD-----LAGEL 1247
Query: 124 SKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQME---VC 180
+G+ + E ++K K L+ + + LQ KC ++ R E + + LQ E V
Sbjct: 1248 RVLGQAKQE-------VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300
Query: 181 RLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQS 240
+ E E + + + A L ++ T ++L L + K+ RQ +E+ +
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDT---QEL--LQEETRQKLNVSTKLRQLEEERNSL 1355
Query: 241 EEENDYRNLDASPTYKGLLMSLQNQLKESKSK-------IDALSSEKLNLQKDLETRPTQ 293
+++ D ++A + + +L QL +SK K ++AL K QK++E Q
Sbjct: 1356 QDQLD-EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1414
Query: 294 HELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQ 346
Y+++ +K K +LQ+ ++ + ++ S ++Q DQ
Sbjct: 1415 -----YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Score = 40.0 bits (92), Expect = 0.006
Identities = 64/276 (23%), Positives = 123/276 (44%), Gaps = 30/276 (10%)
Query: 85 QELIETNQQLRNELQ-LEQSR------AANQEQRANDLEQIMESVKSKIGELEDESLSRA 137
+EL TN+ L+ E++ L S+ E+ LE ME +K+++ ELEDE +
Sbjct: 1507 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT- 1565
Query: 138 CHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQ-EETIASLQMEVCRLKKEEEDRIVTQNRV 196
+ K++ L+ + L+ + + + R EQ EE LQ ++ + E ED Q +
Sbjct: 1566 --EDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE-RKQRAL 1621
Query: 197 FAYLCKRVPHTVLDRQLLC--LIDYYESKIRKIH-TQRQYKEDESQSEEENDYR------ 247
A K++ + D +L I E I+++ Q Q K+ + + E+ R
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 248 ---NLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLET-----RPTQHELRLY 299
N + + + LM LQ L ++ EK L ++L + Q E R
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 300 KQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPS 335
+ ++ +LE+ L++ E ++ + + T++ ++ S
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777
Score = 38.1 bits (87), Expect = 0.023
Identities = 55/246 (22%), Positives = 97/246 (39%), Gaps = 51/246 (20%)
Query: 60 KQSSQRMRQNLKLLVEETSCQQ-------NMIQELIETNQQLRNELQLEQSRAANQEQRA 112
+ +R+ + L EE +Q + +++ + +QL NEL E+S A E
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794
Query: 113 NDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETI 172
LE+ + ++SK+ E+E A + K E K Q++ Q ++ R +Q T
Sbjct: 1795 QQLERQNKELRSKLHEMEG-----AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT- 1848
Query: 173 ASLQMEVCRLKK-----EEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKI 227
SL+ + +LK+ E+E ++ Q + A + R
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQA---------------------EKGNARVK 1887
Query: 228 HTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDL 287
+RQ +E E +S+ N R LQ +L E+ +A+ E L+ L
Sbjct: 1888 QLKRQLEEAEEESQRINANRR------------KLQRELDEATESNEAMGREVNALKSKL 1935
Query: 288 ETRPTQ 293
P Q
Sbjct: 1936 RGPPPQ 1941
Score = 37.4 bits (85), Expect = 0.040
Identities = 64/301 (21%), Positives = 119/301 (39%), Gaps = 22/301 (7%)
Query: 53 KDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRA 112
+DL D+Q+ ++ RQ + ++L E +L +E + AA +++
Sbjct: 1585 RDLQARDEQNEEKRRQ--------------LQRQLHEYETELEDERKQRALAAAAKKKLE 1630
Query: 113 NDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETI 172
DL+ + S I E E++ + Q ++KD Q+E + + E E+
Sbjct: 1631 GDLKDLELQADSAIKGRE-EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1689
Query: 173 ASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQ 232
SL+ ++ +L +E+ + R A L K L L + K R++ +
Sbjct: 1690 KSLEADLMQL--QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK-RRLEARIA 1746
Query: 233 YKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQK-DLETRP 291
E+E + E+ N D L N+L +S S + L++ + E R
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 292 TQHELR-LYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQ 350
HE+ K + K AL+ K+ +L + E EK+ Q+ + + Q
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALE--AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 351 V 351
V
Sbjct: 1865 V 1865
Score = 32.0 bits (71), Expect = 1.7
Identities = 44/227 (19%), Positives = 88/227 (38%), Gaps = 30/227 (13%)
Query: 98 LQLEQSRAANQEQRAN---DLEQIMESVKSKIG---ELEDESLSRACHQQNKIKDLQKEQ 151
+QL++ AA + R + E++ E + S + L+DE ++L++EQ
Sbjct: 1697 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ 1756
Query: 152 KTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDR--IVTQNRVFAYLCKRVPHTVL 209
++ +K + E+ L E +K E R + QN+ + V
Sbjct: 1757 GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK 1816
Query: 210 DRQLLCLIDYYESKIRKIHTQ-------------------RQYKEDESQSEEENDYRNLD 250
+ I E+KI ++ Q ++ KE Q E+E
Sbjct: 1817 SK-FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875
Query: 251 ASPTYKG--LLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHE 295
KG + L+ QL+E++ + +++ + LQ++L+ +E
Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 57.4 bits (137), Expect = 4e-08
Identities = 105/490 (21%), Positives = 208/490 (42%), Gaps = 59/490 (12%)
Query: 41 LKPLSLVKRTD-----LKDLIIFDKQSSQRMRQNLKLLVEETSC---QQNMIQELIETNQ 92
+KPL V R + +D + K+ Q+ LK L ++ S ++N++QE ++
Sbjct: 841 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900
Query: 93 QLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQK 152
+L E + + R A ++Q +LE+I+ +++++ E ED + LQ E+K
Sbjct: 901 ELYAEAEEMRVRLAAKKQ---ELEEILHEMEARLEEEEDRG-----------QQLQAERK 946
Query: 153 TLQVKCQHYKKKRTEQEETIASLQME----VCRLKKEEEDRIV--TQNRVFAYLCKRVPH 206
+ + +++ E+E LQ+E ++KK E++ +V QN + K +
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 207 TVLD------------RQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPT 254
+ D + L L + +ES I ++ R KE++S+ E E R L+ +
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV-RLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 255 -YKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKN 313
+ + LQ Q+ E K ++ A E+L Q L ++ + ALKK
Sbjct: 1066 DFHEQIADLQAQIAELKMQL-AKKEEEL-----------QAALARLDDEIAQKNNALKKI 1113
Query: 314 VKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTK 373
+L+ I+ + + ++ +K +Q+ + + + + + + + + +
Sbjct: 1114 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1173
Query: 374 GGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENE 433
V K L ++ H V EM ++++L + L+ K+ E E
Sbjct: 1174 QEVTVLKKALDEETR-SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 434 GIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNG-VYPRMNEV 492
+ L ++ +EVE+K+K Q LQ+ S ++ LN V+ NEV
Sbjct: 1233 NADLAGELRVLGQAKQEVEHKKKKLE-AQVQELQSKCSDGERA--RAELNDKVHKLQNEV 1289
Query: 493 YTRLGEMNNA 502
+ G +N A
Sbjct: 1290 ESVTGMLNEA 1299
Score = 46.6 bits (109), Expect = 7e-05
Identities = 62/293 (21%), Positives = 124/293 (42%), Gaps = 42/293 (14%)
Query: 64 QRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRANDLEQIMESVK 123
Q MRQ VEE + Q Q R + L++++ +++ A+ +
Sbjct: 1195 QEMRQKHAQAVEELTEQ---------LEQFKRAKANLDKNKQTLEKENAD-----LAGEL 1240
Query: 124 SKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQME---VC 180
+G+ + E ++K K L+ + + LQ KC ++ R E + + LQ E V
Sbjct: 1241 RVLGQAKQE-------VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293
Query: 181 RLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQS 240
+ E E + + + A L ++ T ++L L + K+ RQ +E+ +
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDT---QEL--LQEETRQKLNVSTKLRQLEEERNSL 1348
Query: 241 EEENDYRNLDASPTYKGLLMSLQNQLKESKSK-------IDALSSEKLNLQKDLETRPTQ 293
+++ D ++A + + +L QL +SK K ++AL K QK++E Q
Sbjct: 1349 QDQLD-EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1407
Query: 294 HELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQ 346
Y+++ +K K +LQ+ ++ + ++ S ++Q DQ
Sbjct: 1408 -----YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Score = 40.0 bits (92), Expect = 0.006
Identities = 64/276 (23%), Positives = 123/276 (44%), Gaps = 30/276 (10%)
Query: 85 QELIETNQQLRNELQ-LEQSR------AANQEQRANDLEQIMESVKSKIGELEDESLSRA 137
+EL TN+ L+ E++ L S+ E+ LE ME +K+++ ELEDE +
Sbjct: 1500 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT- 1558
Query: 138 CHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQ-EETIASLQMEVCRLKKEEEDRIVTQNRV 196
+ K++ L+ + L+ + + + R EQ EE LQ ++ + E ED Q +
Sbjct: 1559 --EDAKLR-LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE-RKQRAL 1614
Query: 197 FAYLCKRVPHTVLDRQLLC--LIDYYESKIRKIH-TQRQYKEDESQSEEENDYR------ 247
A K++ + D +L I E I+++ Q Q K+ + + E+ R
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 248 ---NLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLET-----RPTQHELRLY 299
N + + + LM LQ L ++ EK L ++L + Q E R
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 300 KQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPS 335
+ ++ +LE+ L++ E ++ + + T++ ++ S
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770
Score = 38.1 bits (87), Expect = 0.023
Identities = 55/246 (22%), Positives = 97/246 (39%), Gaps = 51/246 (20%)
Query: 60 KQSSQRMRQNLKLLVEETSCQQ-------NMIQELIETNQQLRNELQLEQSRAANQEQRA 112
+ +R+ + L EE +Q + +++ + +QL NEL E+S A E
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1787
Query: 113 NDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETI 172
LE+ + ++SK+ E+E A + K E K Q++ Q ++ R +Q T
Sbjct: 1788 QQLERQNKELRSKLHEMEG-----AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT- 1841
Query: 173 ASLQMEVCRLKK-----EEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKI 227
SL+ + +LK+ E+E ++ Q + A + R
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKEQA---------------------EKGNARVK 1880
Query: 228 HTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDL 287
+RQ +E E +S+ N R LQ +L E+ +A+ E L+ L
Sbjct: 1881 QLKRQLEEAEEESQRINANRR------------KLQRELDEATESNEAMGREVNALKSKL 1928
Query: 288 ETRPTQ 293
P Q
Sbjct: 1929 RGPPPQ 1934
Score = 37.4 bits (85), Expect = 0.040
Identities = 64/301 (21%), Positives = 119/301 (39%), Gaps = 22/301 (7%)
Query: 53 KDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQRA 112
+DL D+Q+ ++ RQ + ++L E +L +E + AA +++
Sbjct: 1578 RDLQARDEQNEEKRRQ--------------LQRQLHEYETELEDERKQRALAAAAKKKLE 1623
Query: 113 NDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETI 172
DL+ + S I E E++ + Q ++KD Q+E + + E E+
Sbjct: 1624 GDLKDLELQADSAIKGRE-EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1682
Query: 173 ASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQ 232
SL+ ++ +L +E+ + R A L K L L + K R++ +
Sbjct: 1683 KSLEADLMQL--QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK-RRLEARIA 1739
Query: 233 YKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQK-DLETRP 291
E+E + E+ N D L N+L +S S + L++ + E R
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 292 TQHELR-LYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQ 350
HE+ K + K AL+ K+ +L + E EK+ Q+ + + Q
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALE--AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 351 V 351
V
Sbjct: 1858 V 1858
Score = 32.0 bits (71), Expect = 1.7
Identities = 44/227 (19%), Positives = 88/227 (38%), Gaps = 30/227 (13%)
Query: 98 LQLEQSRAANQEQRAN---DLEQIMESVKSKIG---ELEDESLSRACHQQNKIKDLQKEQ 151
+QL++ AA + R + E++ E + S + L+DE ++L++EQ
Sbjct: 1690 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ 1749
Query: 152 KTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDR--IVTQNRVFAYLCKRVPHTVL 209
++ +K + E+ L E +K E R + QN+ + V
Sbjct: 1750 GNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK 1809
Query: 210 DRQLLCLIDYYESKIRKIHTQ-------------------RQYKEDESQSEEENDYRNLD 250
+ I E+KI ++ Q ++ KE Q E+E
Sbjct: 1810 SK-FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868
Query: 251 ASPTYKG--LLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHE 295
KG + L+ QL+E++ + +++ + LQ++L+ +E
Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.356
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,872,502
Number of Sequences: 37866
Number of extensions: 923488
Number of successful extensions: 8201
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 173
Number of HSP's successfully gapped in prelim test: 761
Number of HSP's that attempted gapping in prelim test: 4790
Number of HSP's gapped (non-prelim): 2636
length of query: 597
length of database: 18,247,518
effective HSP length: 108
effective length of query: 489
effective length of database: 14,157,990
effective search space: 6923257110
effective search space used: 6923257110
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.