Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 50582996
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50582996 multiple C2 domains, transmembrane 1 isoform S
[Homo sapiens]
(778 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo... 1568 0.0
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom... 1528 0.0
gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Hom... 735 0.0
gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Hom... 501 e-141
gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Hom... 318 9e-87
gi|6005997 double C2-like domains, beta [Homo sapiens] 94 4e-19
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 93 1e-18
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 93 1e-18
gi|47078261 double C2-like domains, alpha [Homo sapiens] 91 4e-18
gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens] 90 9e-18
gi|209447073 synaptotagmin I [Homo sapiens] 84 7e-16
gi|5032139 synaptotagmin I [Homo sapiens] 84 7e-16
gi|209447070 synaptotagmin I [Homo sapiens] 84 7e-16
gi|211059429 synaptotagmin II [Homo sapiens] 80 9e-15
gi|31543670 synaptotagmin II [Homo sapiens] 80 9e-15
gi|45387945 family with sequence similarity 62 (C2 domain contai... 79 2e-14
gi|92859638 synaptotagmin V [Homo sapiens] 76 1e-13
gi|4506067 protein kinase C, alpha [Homo sapiens] 72 2e-12
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 72 2e-12
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 72 2e-12
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 72 3e-12
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 72 3e-12
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 72 3e-12
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 72 3e-12
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 72 3e-12
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 72 3e-12
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 72 3e-12
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 72 3e-12
gi|38570146 synaptotagmin VII [Homo sapiens] 72 3e-12
gi|103472031 family with sequence similarity 62 (C2 domain conta... 71 3e-12
>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
sapiens]
Length = 778
Score = 1568 bits (4059), Expect = 0.0
Identities = 778/778 (100%), Positives = 778/778 (100%)
Query: 1 MLDSCKLKSACNLPFICNKKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGT 60
MLDSCKLKSACNLPFICNKKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGT
Sbjct: 1 MLDSCKLKSACNLPFICNKKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGT 60
Query: 61 SDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMG 120
SDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMG
Sbjct: 61 SDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMG 120
Query: 121 SAFLDLTQLELNRPTDVTLTLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKR 180
SAFLDLTQLELNRPTDVTLTLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKR
Sbjct: 121 SAFLDLTQLELNRPTDVTLTLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKR 180
Query: 181 SSKELSENEVVGSYFSVKSLFWRTCGRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDL 240
SSKELSENEVVGSYFSVKSLFWRTCGRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDL
Sbjct: 181 SSKELSENEVVGSYFSVKSLFWRTCGRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDL 240
Query: 241 HRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQF 300
HRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQF
Sbjct: 241 HRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQF 300
Query: 301 DFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLL 360
DFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLL
Sbjct: 301 DFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLL 360
Query: 361 VTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAA 420
VTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAA
Sbjct: 361 VTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAA 420
Query: 421 DVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSA 480
DVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSA
Sbjct: 421 DVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSA 480
Query: 481 DFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQK 540
DFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQK
Sbjct: 481 DFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQK 540
Query: 541 YIEEENRLSKQLLLRNFIRMKRCVMVLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNF 600
YIEEENRLSKQLLLRNFIRMKRCVMVLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNF
Sbjct: 541 YIEEENRLSKQLLLRNFIRMKRCVMVLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNF 600
Query: 601 ELYMIPLVLLLLLTWNYFLIISGKDNRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKI 660
ELYMIPLVLLLLLTWNYFLIISGKDNRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKI
Sbjct: 601 ELYMIPLVLLLLLTWNYFLIISGKDNRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKI 660
Query: 661 YAIQEVCVSVQNILDEVASFGERIKNTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVL 720
YAIQEVCVSVQNILDEVASFGERIKNTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVL
Sbjct: 661 YAIQEVCVSVQNILDEVASFGERIKNTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVL 720
Query: 721 VWGINKFTKKLRSPYAIDNNELLDFLSRVPSDVQVVQYQELKPDPSHSPYKRKKNNLG 778
VWGINKFTKKLRSPYAIDNNELLDFLSRVPSDVQVVQYQELKPDPSHSPYKRKKNNLG
Sbjct: 721 VWGINKFTKKLRSPYAIDNNELLDFLSRVPSDVQVVQYQELKPDPSHSPYKRKKNNLG 778
>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
sapiens]
Length = 999
Score = 1528 bits (3955), Expect = 0.0
Identities = 759/761 (99%), Positives = 761/761 (100%)
Query: 18 NKKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRS 77
++KIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRS
Sbjct: 239 SQKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRS 298
Query: 78 KIIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDV 137
KIIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDV
Sbjct: 299 KIIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDV 358
Query: 138 TLTLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSV 197
TLTLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSV
Sbjct: 359 TLTLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSV 418
Query: 198 KSLFWRTCGRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIE 257
KSLFWRTCGRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIE
Sbjct: 419 KSLFWRTCGRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIE 478
Query: 258 GRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAW 317
GRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAW
Sbjct: 479 GRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAW 538
Query: 318 DKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVN 377
DKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVN
Sbjct: 539 DKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVN 598
Query: 378 SLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNND 437
SLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNND
Sbjct: 599 SLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNND 658
Query: 438 RLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGE 497
RLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGE
Sbjct: 659 RLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGE 718
Query: 498 QKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNF 557
QKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNF
Sbjct: 719 QKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNF 778
Query: 558 IRMKRCVMVLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTWNY 617
IRMKRCVMVLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTWNY
Sbjct: 779 IRMKRCVMVLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTWNY 838
Query: 618 FLIISGKDNRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCVSVQNILDEV 677
FLIISGKDNRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCVSVQNILDEV
Sbjct: 839 FLIISGKDNRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCVSVQNILDEV 898
Query: 678 ASFGERIKNTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVLVWGINKFTKKLRSPYAI 737
ASFGERIKNTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVLVWGINKFTKKLRSPYAI
Sbjct: 899 ASFGERIKNTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVLVWGINKFTKKLRSPYAI 958
Query: 738 DNNELLDFLSRVPSDVQVVQYQELKPDPSHSPYKRKKNNLG 778
DNNELLDFLSRVPSDVQVVQYQELKPDPSHSPYKRKKNNLG
Sbjct: 959 DNNELLDFLSRVPSDVQVVQYQELKPDPSHSPYKRKKNNLG 999
>gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Homo
sapiens]
Length = 878
Score = 735 bits (1898), Expect = 0.0
Identities = 384/752 (51%), Positives = 510/752 (67%), Gaps = 57/752 (7%)
Query: 26 GTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLN 85
G SN P A Y L I L+ G++L RDR GTSDPYVKFK+ GK +++SK+I+KNLN
Sbjct: 184 GLSNLPSPFA----YLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLN 239
Query: 86 PVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPH 145
PVW+E + + L + L +KV+D D DFMGSAF+ L+ LELNR T+ L L+DP+
Sbjct: 240 PVWDEIVVLPIQSLDQKLRVKVYDRDL-TTSDFMGSAFVILSDLELNRTTEHILKLEDPN 298
Query: 146 YPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVKSLFWRTC 205
+ D+G+I+L++ L K+G+ + RK S L N
Sbjct: 299 SLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRN----------------- 341
Query: 206 GRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIEGRDLKAMD 265
LRLS+ +K+ LW GI+SITL+EG+++
Sbjct: 342 -----------------------------LRLSESLKKNQLWNGIISITLLEGKNVSG-- 370
Query: 266 SNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDKDAGKRD 325
+++ +V+ +LG Q+YKSK + K+ NPQW+EQFDFH + +R G++DI W KD K +
Sbjct: 371 -GSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKHE 429
Query: 326 DFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVNSLEDQKER 385
+ +G C+VD+SAL +Q + LEL L+ G L++LVTLT A VS+SDL V L D ER
Sbjct: 430 ERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSER 489
Query: 386 EEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVY 445
++I +RY ++KDVG LQVKV++A L+AAD +GKSDPFC++EL NDRL THTVY
Sbjct: 490 KQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVY 549
Query: 446 KNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLKN 505
KNLNPEWNKVFTF IKDIH VLEVTV+DED D+ DFLGKVAIPLLSI++G+ YVLKN
Sbjct: 550 KNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKN 609
Query: 506 KQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNFIRMKRCVM 565
K L KGVIYLE+D+I+N VKAS+RT P+E++++E+ +LSK++L R+ R+KR M
Sbjct: 610 KDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRDVDRVKRITM 669
Query: 566 VLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTWNYFLIISGKD 625
+ N ++ SCF W+S RS AF +FL VWNFELYMIPL LLL+ +N+ + GK
Sbjct: 670 AIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYNFIRPVKGKV 729
Query: 626 NRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCVSVQNILDEVASFGERIK 685
+ +D+ ++DEE D+DDK+SEKKG I +IY +Q++ +VQN+L+E+ASFGERIK
Sbjct: 730 SSIQDSQESTDIDDEE---DEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIASFGERIK 786
Query: 686 NTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVLVWGINKFTKKLRSPYAIDNNELLDF 745
NTFNWTVPFLS LA + L T ILY IPLRYI+L+WGINKFTKKLR+PY+IDNNELLDF
Sbjct: 787 NTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDNNELLDF 846
Query: 746 LSRVPSDVQVVQYQELKPDPSHSPYKRKKNNL 777
LSRVPSDVQ VQY ELK SHSP ++K++ L
Sbjct: 847 LSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL 878
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/189 (23%), Positives = 80/189 (42%), Gaps = 7/189 (3%)
Query: 19 KKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSK 78
K+I N+ + D G+ Q+ + + L A D G SDP+ ++G + ++
Sbjct: 490 KQITQRYCLQNSLKDVKDVGILQVKVL--KAADLLAADFSGKSDPFCLLELGNDRL-QTH 546
Query: 79 IIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVT 138
++KNLNP W + + + + L + VFD D DF+G + L + +P
Sbjct: 547 TVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYV 606
Query: 139 LTLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVK 198
L KD + + + +I P + R T K + S++LS+ + VK
Sbjct: 607 LKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTP-REKRFVEDSRKLSKKILSRDVDRVK 665
Query: 199 SL---FWRT 204
+ W T
Sbjct: 666 RITMAIWNT 674
>gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Homo
sapiens]
Length = 823
Score = 501 bits (1289), Expect = e-141
Identities = 267/565 (47%), Positives = 364/565 (64%), Gaps = 54/565 (9%)
Query: 26 GTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLN 85
G SN P A Y L I L+ G++L RDR GTSDPYVKFK+ GK +++SK+I+KNLN
Sbjct: 184 GLSNLPSPFA----YLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLN 239
Query: 86 PVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPH 145
PVW+E + + L + L +KV+D D DFMGSAF+ L+ LELNR T+ L L+DP+
Sbjct: 240 PVWDEIVVLPIQSLDQKLRVKVYDRDL-TTSDFMGSAFVILSDLELNRTTEHILKLEDPN 298
Query: 146 YPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVKSLFWRTC 205
+ D+G+I+L++ L K+G+ + RK S L N
Sbjct: 299 SLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRN----------------- 341
Query: 206 GRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIEGRDLKAMD 265
LRLS+ +K+ LW GI+SITL+EG+++
Sbjct: 342 -----------------------------LRLSESLKKNQLWNGIISITLLEGKNVSG-- 370
Query: 266 SNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDKDAGKRD 325
+++ +V+ +LG Q+YKSK + K+ NPQW+EQFDFH + +R G++DI W KD K +
Sbjct: 371 -GSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKHE 429
Query: 326 DFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVNSLEDQKER 385
+ +G C+VD+SAL +Q + LEL L+ G L++LVTLT A VS+SDL V L D ER
Sbjct: 430 ERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSER 489
Query: 386 EEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVY 445
++I +RY ++KDVG LQVKV++A L+AAD +GKSDPFC++EL NDRL THTVY
Sbjct: 490 KQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVY 549
Query: 446 KNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLKN 505
KNLNPEWNKVFTF IKDIH VLEVTV+DED D+ DFLGKVAIPLLSI++G+ YVLKN
Sbjct: 550 KNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKN 609
Query: 506 KQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNFIRMKRCVM 565
K L KGVIYLE+D+I+N VKAS+RT P+E++++E+ +LSK++L R+ R+KR M
Sbjct: 610 KDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRDVDRVKRITM 669
Query: 566 VLVNAAYYVNSCFDWDSPPRSLAAF 590
+ N ++ SCF W+S RS AF
Sbjct: 670 AIWNTMQFLKSCFQWESTLRSTIAF 694
Score = 188 bits (477), Expect = 2e-47
Identities = 90/128 (70%), Positives = 108/128 (84%)
Query: 650 DSEKKGFINKIYAIQEVCVSVQNILDEVASFGERIKNTFNWTVPFLSWLAIVALCVFTAI 709
+SEKKG I +IY +Q++ +VQN+L+E+ASFGERIKNTFNWTVPFLS LA + L T I
Sbjct: 696 ESEKKGLIERIYMVQDIVSTVQNVLEEIASFGERIKNTFNWTVPFLSSLACLILAAATII 755
Query: 710 LYCIPLRYIVLVWGINKFTKKLRSPYAIDNNELLDFLSRVPSDVQVVQYQELKPDPSHSP 769
LY IPLRYI+L+WGINKFTKKLR+PY+IDNNELLDFLSRVPSDVQ VQY ELK SHSP
Sbjct: 756 LYFIPLRYIILIWGINKFTKKLRNPYSIDNNELLDFLSRVPSDVQKVQYAELKLCSSHSP 815
Query: 770 YKRKKNNL 777
++K++ L
Sbjct: 816 LRKKRSAL 823
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/189 (23%), Positives = 80/189 (42%), Gaps = 7/189 (3%)
Query: 19 KKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSK 78
K+I N+ + D G+ Q+ + + L A D G SDP+ ++G + ++
Sbjct: 490 KQITQRYCLQNSLKDVKDVGILQVKVL--KAADLLAADFSGKSDPFCLLELGNDRL-QTH 546
Query: 79 IIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVT 138
++KNLNP W + + + + L + VFD D DF+G + L + +P
Sbjct: 547 TVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYV 606
Query: 139 LTLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVK 198
L KD + + + +I P + R T K + S++LS+ + VK
Sbjct: 607 LKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTP-REKRFVEDSRKLSKKILSRDVDRVK 665
Query: 199 SL---FWRT 204
+ W T
Sbjct: 666 RITMAIWNT 674
>gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Homo
sapiens]
Length = 306
Score = 318 bits (816), Expect = 9e-87
Identities = 159/281 (56%), Positives = 207/281 (73%)
Query: 310 GVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATV 369
G++DI W KD K ++ +G C+VD+SAL +Q + LEL L+ G L++LVTLT A V
Sbjct: 2 GILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGV 61
Query: 370 SISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPF 429
S+SDL V L D ER++I +RY ++KDVG LQVKV++A L+AAD +GKSDPF
Sbjct: 62 SVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPF 121
Query: 430 CVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIP 489
C++EL NDRL THTVYKNLNPEWNKVFTF IKDIH VLEVTV+DED D+ DFLGKVAIP
Sbjct: 122 CLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIP 181
Query: 490 LLSIQNGEQKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLS 549
LLSI++G+ YVLKNK L KGVIYLE+D+I+N VKAS+RT P+E++++E+ +LS
Sbjct: 182 LLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLS 241
Query: 550 KQLLLRNFIRMKRCVMVLVNAAYYVNSCFDWDSPPRSLAAF 590
K++L R+ R+KR M + N ++ SCF W+S RS AF
Sbjct: 242 KKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAF 282
Score = 62.8 bits (151), Expect = 1e-09
Identities = 28/90 (31%), Positives = 55/90 (61%), Gaps = 1/90 (1%)
Query: 249 GIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEER 308
GI+ + +++ DL A D +G SDP+ LG+ + ++ + K LNP+W + F F + ++
Sbjct: 97 GILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPI-KDI 155
Query: 309 GGVIDITAWDKDAGKRDDFIGRCQVDLSAL 338
V+++T +D+D K DF+G+ + L ++
Sbjct: 156 HDVLEVTVFDEDGDKPPDFLGKVAIPLLSI 185
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/189 (23%), Positives = 80/189 (42%), Gaps = 7/189 (3%)
Query: 19 KKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSK 78
K+I N+ + D G+ Q+ + + L A D G SDP+ ++G + ++
Sbjct: 78 KQITQRYCLQNSLKDVKDVGILQVKVL--KAADLLAADFSGKSDPFCLLELGNDRL-QTH 134
Query: 79 IIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVT 138
++KNLNP W + + + + L + VFD D DF+G + L + +P
Sbjct: 135 TVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYV 194
Query: 139 LTLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVK 198
L KD + + + +I P + R T K + S++LS+ + VK
Sbjct: 195 LKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTP-REKRFVEDSRKLSKKILSRDVDRVK 253
Query: 199 SL---FWRT 204
+ W T
Sbjct: 254 RITMAIWNT 262
>gi|6005997 double C2-like domains, beta [Homo sapiens]
Length = 412
Score = 94.4 bits (233), Expect = 4e-19
Identities = 83/274 (30%), Positives = 126/274 (45%), Gaps = 49/274 (17%)
Query: 254 TLIEGRDLKAMDSNGLSDPYVKFRL-----GHQKYKSKIMPKTLNPQWREQFDFHLYEER 308
T+ + + LK MD NGL+DPYVK L K ++K + TLNP W E ++ +
Sbjct: 146 TITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDE 205
Query: 309 GGV---IDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTA 365
+ + I+ D+D + ++FIG +V L L T + LE+
Sbjct: 206 DMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFNICLEK------------- 252
Query: 366 SATVSISDLSVNSLEDQ--KEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVT 423
L V+ ED+ +ER IL + + ++ + G L V ++R L A D
Sbjct: 253 -------QLPVDKTEDKSLEERGRIL-----ISLKYSSQKQGLL-VGIVRCAHLAAMDAN 299
Query: 424 GKSDPFCVVELNND-----RLLTHTVYKNLNPEWNKVFTFNIKD---IHSVLEVTVYDED 475
G SDP+ L D + T K LNPE+N+ F + IK LEVTV+D D
Sbjct: 300 GYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYD 359
Query: 476 RDRSADFLGKVAIPLLSIQNGEQKAY---VLKNK 506
+S DF+G V + + + GE+ + LKNK
Sbjct: 360 IGKSNDFIGGVVLGIHA--KGERLKHWFDCLKNK 391
Score = 62.8 bits (151), Expect = 1e-09
Identities = 37/102 (36%), Positives = 54/102 (52%), Gaps = 13/102 (12%)
Query: 253 ITLIEGRDLKAMDSNGLSDPYVKFRL-----GHQKYKSKIMPKTLNPQWREQFDFHLYEE 307
+ ++ L AMD+NG SDPYVK L K+K+ + KTLNP++ E+F YE
Sbjct: 285 VGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEF---CYEI 341
Query: 308 RGG-----VIDITAWDKDAGKRDDFIGRCQVDLSALSREQTH 344
+ G +++T WD D GK +DFIG + + A H
Sbjct: 342 KHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKH 383
Score = 56.2 bits (134), Expect = 1e-07
Identities = 35/112 (31%), Positives = 57/112 (50%), Gaps = 10/112 (8%)
Query: 407 LQVKVIRAEGLMAADVTGKSDPFCVVEL-----NNDRLLTHTVYKNLNPEWNKVFT-FNI 460
L + +A+GL D G +DP+ + L ++L T T+ LNP WN+ T + I
Sbjct: 143 LHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGI 202
Query: 461 KD---IHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAY-VLKNKQL 508
D I L ++V DED+ R +F+G+ +PL ++ K + + KQL
Sbjct: 203 TDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFNICLEKQL 254
Score = 51.2 bits (121), Expect = 4e-06
Identities = 29/82 (35%), Positives = 43/82 (52%), Gaps = 7/82 (8%)
Query: 52 LAARDRGGTSDPYVKF----KIGGKEVFRSKIIHKNLNPVWEEKACILVDH---LREPLY 104
LAA D G SDPYVK + K ++ + K LNP + E+ C + H ++ L
Sbjct: 293 LAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLE 352
Query: 105 IKVFDYDFGLQDDFMGSAFLDL 126
+ V+DYD G +DF+G L +
Sbjct: 353 VTVWDYDIGKSNDFIGGVVLGI 374
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 8/109 (7%)
Query: 42 LDITLRRGQSLAARDRGGTSDPYVKFKI--GGKEV--FRSKIIHKNLNPVWEEKACIL-- 95
L T+ + + L D G +DPYVK + G + R+K + LNP W E
Sbjct: 143 LHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGI 202
Query: 96 --VDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLK 142
D +R+ L I V D D ++F+G + L +L+ N + L+
Sbjct: 203 TDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFNICLE 251
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 92.8 bits (229), Expect = 1e-18
Identities = 74/247 (29%), Positives = 116/247 (46%), Gaps = 22/247 (8%)
Query: 254 TLIEGRDLKAMDSNGLSDPYVKFRL-----GHQKYKSKIMPKTLNPQWREQFDFHLYEE- 307
T+I+ + LK MDSNGL+DPYVK L K ++K + T NP W E +H +
Sbjct: 412 TIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDE 471
Query: 308 --RGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTA 365
+ + I+ D+D ++FIG + L L Q + LE T +A
Sbjct: 472 DMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSA 531
Query: 366 SATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGK 425
+ V + D +ER +IL + + ++ + G + V +IR L A D G
Sbjct: 532 RGMALYEEEQVERVGDIEERGKIL-----VSLMYSTQQGGLI-VGIIRCVHLAAMDANGY 585
Query: 426 SDPFCVVELNND-----RLLTHTVYKNLNPEWNKVFTFNIKD---IHSVLEVTVYDEDRD 477
SDPF + L D + T K LNPE+N+ F ++IK L+++V+D D
Sbjct: 586 SDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIG 645
Query: 478 RSADFLG 484
+S D++G
Sbjct: 646 KSNDYIG 652
Score = 69.7 bits (169), Expect = 1e-11
Identities = 40/107 (37%), Positives = 60/107 (56%), Gaps = 7/107 (6%)
Query: 248 RGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQ-----KYKSKIMPKTLNPQWREQFDF 302
+G + + +I L AMD+NG SDP+VK L K+K++I KTLNP++ E+F +
Sbjct: 564 QGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFY 623
Query: 303 HLYEE--RGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLE 347
+ +DI+ WD D GK +D+IG CQ+ +SA H E
Sbjct: 624 DIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYE 670
Score = 49.3 bits (116), Expect = 1e-05
Identities = 35/135 (25%), Positives = 63/135 (46%), Gaps = 17/135 (12%)
Query: 402 KDVGFLQVKVIRAEGLMAADVTGKSDPFCVVEL-----NNDRLLTHTVYKNLNPEWNKVF 456
+D LQ +I+A+GL D G +DP+ + L +++L T T+ NP WN+
Sbjct: 404 QDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETL 463
Query: 457 TFN-IKD---IHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAY--------VLK 504
++ I D L ++V DED+ +F+G+ L ++ ++K + +K
Sbjct: 464 VYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMK 523
Query: 505 NKQLTGPTKGVIYLE 519
TG +G+ E
Sbjct: 524 RAGTTGSARGMALYE 538
Score = 47.4 bits (111), Expect = 5e-05
Identities = 29/83 (34%), Positives = 45/83 (54%), Gaps = 7/83 (8%)
Query: 52 LAARDRGGTSDPYVKF----KIGGKEVFRSKIIHKNLNPVWEEKACILVDH---LREPLY 104
LAA D G SDP+VK +G K +++I K LNP + E+ + H ++ L
Sbjct: 577 LAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLD 636
Query: 105 IKVFDYDFGLQDDFMGSAFLDLT 127
I V+DYD G +D++G L ++
Sbjct: 637 ISVWDYDIGKSNDYIGGCQLGIS 659
Score = 42.0 bits (97), Expect = 0.002
Identities = 31/117 (26%), Positives = 49/117 (41%), Gaps = 8/117 (6%)
Query: 34 LADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKI----GGKEVFRSKIIHKNLNPVWE 89
L D L T+ + + L D G +DPYVK + R+K + NP+W
Sbjct: 401 LYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWN 460
Query: 90 E----KACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLK 142
E D R+ L I V D D ++F+G L +L+ N+ + + L+
Sbjct: 461 ETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLE 517
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 92.8 bits (229), Expect = 1e-18
Identities = 74/247 (29%), Positives = 116/247 (46%), Gaps = 22/247 (8%)
Query: 254 TLIEGRDLKAMDSNGLSDPYVKFRL-----GHQKYKSKIMPKTLNPQWREQFDFHLYEE- 307
T+I+ + LK MDSNGL+DPYVK L K ++K + T NP W E +H +
Sbjct: 408 TIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDE 467
Query: 308 --RGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTA 365
+ + I+ D+D ++FIG + L L Q + LE T +A
Sbjct: 468 DMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSA 527
Query: 366 SATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGK 425
+ V + D +ER +IL + + ++ + G + V +IR L A D G
Sbjct: 528 RGMALYEEEQVERVGDIEERGKIL-----VSLMYSTQQGGLI-VGIIRCVHLAAMDANGY 581
Query: 426 SDPFCVVELNND-----RLLTHTVYKNLNPEWNKVFTFNIKD---IHSVLEVTVYDEDRD 477
SDPF + L D + T K LNPE+N+ F ++IK L+++V+D D
Sbjct: 582 SDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYDIG 641
Query: 478 RSADFLG 484
+S D++G
Sbjct: 642 KSNDYIG 648
Score = 69.7 bits (169), Expect = 1e-11
Identities = 40/107 (37%), Positives = 60/107 (56%), Gaps = 7/107 (6%)
Query: 248 RGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQ-----KYKSKIMPKTLNPQWREQFDF 302
+G + + +I L AMD+NG SDP+VK L K+K++I KTLNP++ E+F +
Sbjct: 560 QGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFY 619
Query: 303 HLYEE--RGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLE 347
+ +DI+ WD D GK +D+IG CQ+ +SA H E
Sbjct: 620 DIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYE 666
Score = 49.3 bits (116), Expect = 1e-05
Identities = 35/135 (25%), Positives = 63/135 (46%), Gaps = 17/135 (12%)
Query: 402 KDVGFLQVKVIRAEGLMAADVTGKSDPFCVVEL-----NNDRLLTHTVYKNLNPEWNKVF 456
+D LQ +I+A+GL D G +DP+ + L +++L T T+ NP WN+
Sbjct: 400 QDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETL 459
Query: 457 TFN-IKD---IHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAY--------VLK 504
++ I D L ++V DED+ +F+G+ L ++ ++K + +K
Sbjct: 460 VYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMK 519
Query: 505 NKQLTGPTKGVIYLE 519
TG +G+ E
Sbjct: 520 RAGTTGSARGMALYE 534
Score = 47.4 bits (111), Expect = 5e-05
Identities = 29/83 (34%), Positives = 45/83 (54%), Gaps = 7/83 (8%)
Query: 52 LAARDRGGTSDPYVKF----KIGGKEVFRSKIIHKNLNPVWEEKACILVDH---LREPLY 104
LAA D G SDP+VK +G K +++I K LNP + E+ + H ++ L
Sbjct: 573 LAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLD 632
Query: 105 IKVFDYDFGLQDDFMGSAFLDLT 127
I V+DYD G +D++G L ++
Sbjct: 633 ISVWDYDIGKSNDYIGGCQLGIS 655
Score = 42.0 bits (97), Expect = 0.002
Identities = 31/117 (26%), Positives = 49/117 (41%), Gaps = 8/117 (6%)
Query: 34 LADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKI----GGKEVFRSKIIHKNLNPVWE 89
L D L T+ + + L D G +DPYVK + R+K + NP+W
Sbjct: 397 LYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWN 456
Query: 90 E----KACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLK 142
E D R+ L I V D D ++F+G L +L+ N+ + + L+
Sbjct: 457 ETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLE 513
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 90.9 bits (224), Expect = 4e-18
Identities = 77/253 (30%), Positives = 117/253 (46%), Gaps = 22/253 (8%)
Query: 254 TLIEGRDLKAMDSNGLSDPYVKFRL-----GHQKYKSKIMPKTLNPQWREQFDFHLYEE- 307
+++ + LK MD NGL+DPYVK L K K+K TLNP W E + +
Sbjct: 109 SILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDD 168
Query: 308 --RGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTA 365
V+ I D+D ++FIG +V L L Q + LE + L +
Sbjct: 169 DITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLER---QVPLASPSSM 225
Query: 366 SATVSISDLSVNSLEDQKEREEILKRYSP--LRIFHNLKDVGFLQVKVIRAEGLMAADVT 423
SA + + LE ++ + +L+ L + ++ + G L V ++R L A DV
Sbjct: 226 SAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLL-VGILRCAHLAAMDVN 284
Query: 424 GKSDPFCVVELNND-----RLLTHTVYKNLNPEWNKVFTFNIK---DIHSVLEVTVYDED 475
G SDP+ L D + T K LNPE+N+ F + I+ LEVTV+D D
Sbjct: 285 GYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYD 344
Query: 476 RDRSADFLGKVAI 488
+S DF+G V++
Sbjct: 345 IGKSNDFIGGVSL 357
Score = 62.0 bits (149), Expect = 2e-09
Identities = 44/135 (32%), Positives = 68/135 (50%), Gaps = 9/135 (6%)
Query: 248 RGIVSITLIEGRDLKAMDSNGLSDPYVKFRLG-----HQKYKSKIMPKTLNPQWREQF-- 300
RG++ + ++ L AMD NG SDPYVK L K+K+ + KTLNP++ E+F
Sbjct: 266 RGLL-VGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFY 324
Query: 301 DFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLL 360
+ L +++T WD D GK +DFIG + A + H + L++ + L
Sbjct: 325 EIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDC-LQQPDAALERW 383
Query: 361 VTLTASATVSISDLS 375
TLT+ + LS
Sbjct: 384 HTLTSELPPAAGALS 398
Score = 57.8 bits (138), Expect = 4e-08
Identities = 33/104 (31%), Positives = 56/104 (53%), Gaps = 9/104 (8%)
Query: 407 LQVKVIRAEGLMAADVTGKSDPFCVVEL-----NNDRLLTHTVYKNLNPEWNKVFTFN-I 460
L ++RA+GL D G +DP+ + L ++L T T LNP WN+ T++ I
Sbjct: 106 LHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGI 165
Query: 461 KD---IHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAY 501
D H VL + V DED+ +F+G++ +PL ++ ++K +
Sbjct: 166 TDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHF 209
Score = 40.8 bits (94), Expect = 0.005
Identities = 28/88 (31%), Positives = 43/88 (48%), Gaps = 7/88 (7%)
Query: 44 ITLRRGQSLAARDRGGTSDPYVKF----KIGGKEVFRSKIIHKNLNPVWEEKACILVDH- 98
+ + R LAA D G SDPYVK + K ++ + K LNP + E+ ++
Sbjct: 270 VGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELS 329
Query: 99 --LREPLYIKVFDYDFGLQDDFMGSAFL 124
+ L + V+DYD G +DF+G L
Sbjct: 330 TLATKTLEVTVWDYDIGKSNDFIGGVSL 357
Score = 34.3 bits (77), Expect = 0.45
Identities = 31/117 (26%), Positives = 50/117 (42%), Gaps = 8/117 (6%)
Query: 34 LADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKI--GGKEV--FRSKIIHKNLNPVWE 89
L D L ++ R + L D G +DPYVK + G + ++K LNPVW
Sbjct: 98 LYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWN 157
Query: 90 E----KACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLK 142
E D + L I V D D ++F+G + L +L+ ++ + L+
Sbjct: 158 EDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLE 214
>gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens]
Length = 1104
Score = 89.7 bits (221), Expect = 9e-18
Identities = 71/255 (27%), Positives = 121/255 (47%), Gaps = 23/255 (9%)
Query: 243 KSHLWRGIVSITLIEGRDLKAMDS------NGLSDPYVKFRLGHQKYKSKIMPKTLNPQW 296
+S L RGI+ I L+ R L + D G SDPY RLG Q + S+++ + LNPQW
Sbjct: 323 RSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQW 382
Query: 297 REQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGH 356
E ++ ++E G I++ +DKD K DDF+GR ++D+ + + L+ G+G
Sbjct: 383 GETYEVMVHEVPGQEIEVEVFDKDPDK-DDFLGRMKLDVGKVLQASVLDDWFPLQGGQGQ 441
Query: 357 LVLLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEG 416
+ L + ++ L D ++ E++L+ + + L V + RA+
Sbjct: 442 VHLRLEW------------LSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQD 489
Query: 417 LMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHS-VLEVTVYDED 475
L + +P + + + + VY P W + F F ++D S L+V V D+
Sbjct: 490 LPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKDDS 549
Query: 476 RDRSADFLGKVAIPL 490
R A LG + +PL
Sbjct: 550 R---ALTLGALTLPL 561
Score = 84.7 bits (208), Expect = 3e-16
Identities = 72/260 (27%), Positives = 120/260 (46%), Gaps = 30/260 (11%)
Query: 250 IVSITLIEGRDLKAMDS------NGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFH 303
++ I ++E +DL A D G SDPYVK +L + ++S ++ + LNP+W E F+
Sbjct: 648 VLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVI 707
Query: 304 LYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEE---GEGHLVL- 359
+ G +++ +DKD K DDF+GRC+V L+ + L LE+ G HL L
Sbjct: 708 VTSVPGQELEVEVFDKDLDK-DDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLE 766
Query: 360 LVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMA 419
+T +A L VNSL ++ E+ L + + RAE L
Sbjct: 767 RLTPRPTAAELEEVLQVNSLIQTQKSAELA--------------AALLSIYMERAEDLPL 812
Query: 420 ADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHS-VLEVTVYDEDRDR 478
T P+ + + + T T+ + P W++ +F I+ H+ LE+ V R
Sbjct: 813 RKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQV----RGE 868
Query: 479 SADFLGKVAIPLLSIQNGEQ 498
LG +++PL + +Q
Sbjct: 869 GTGVLGSLSLPLSELLVADQ 888
Score = 61.2 bits (147), Expect = 3e-09
Identities = 50/152 (32%), Positives = 76/152 (50%), Gaps = 11/152 (7%)
Query: 42 LDITLRRGQSLAARDR------GGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACIL 95
L I + Q L A+DR G SDPYVK K+ G+ FRS ++ ++LNP W E ++
Sbjct: 649 LRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRS-FRSHVVREDLNPRWNEVFEVI 707
Query: 96 VDHL-REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHDLGII 154
V + + L ++VFD D +DDF+G + LT + + D LTL+D P L +
Sbjct: 708 VTSVPGQELEVEVFDKDLD-KDDFLGRCKVRLTTVLNSGFLDEWLTLED--VPSGRLHLR 764
Query: 155 LLSVILTPKEGESRDVTMLMRKSWKRSSKELS 186
L + P E +V + + S EL+
Sbjct: 765 LERLTPRPTAAELEEVLQVNSLIQTQKSAELA 796
Score = 43.5 bits (101), Expect = 7e-04
Identities = 30/96 (31%), Positives = 54/96 (56%), Gaps = 11/96 (11%)
Query: 38 GMYQLDITLRRGQSLAARDR------GGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEK 91
G+ ++ + RG L+++D+ G SDPY ++G + F S++I + LNP W E
Sbjct: 329 GIIRIHLLAARG--LSSKDKYVKGLIEGKSDPYALVRLG-TQTFCSRVIDEELNPQWGET 385
Query: 92 ACILVDHL-REPLYIKVFDYDFGLQDDFMGSAFLDL 126
++V + + + ++VFD D +DDF+G LD+
Sbjct: 386 YEVMVHEVPGQEIEVEVFDKDPD-KDDFLGRMKLDV 420
Score = 32.7 bits (73), Expect = 1.3
Identities = 33/148 (22%), Positives = 56/148 (37%), Gaps = 14/148 (9%)
Query: 218 AELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFR 277
AEL+ N QTQ + + L ++SI + DL PY
Sbjct: 775 AELEEVLQVNSLIQTQ--------KSAELAAALLSIYMERAEDLPLRKGTKHLSPYATLT 826
Query: 278 LGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSA 337
+G +K+K + +T P W E F + + +++ G+ +G + LS
Sbjct: 827 VGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQV----RGEGTGVLGSLSLPLSE 882
Query: 338 LSREQTHKLE--LQLEEGEGHLVLLVTL 363
L L+ L G+G ++L L
Sbjct: 883 LLVADQLCLDRWFTLSSGQGQVLLRAQL 910
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 83.6 bits (205), Expect = 7e-16
Identities = 79/251 (31%), Positives = 119/251 (47%), Gaps = 47/251 (18%)
Query: 253 ITLIEGRDLKAMDSNGLSDPYVKFRL---GHQKYKSKIMPKTLNPQWREQFDFHL-YEER 308
+ +I+ +L A+D G SDPYVK L +K+++K+ KTLNP + EQF F + Y E
Sbjct: 161 VGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSEL 220
Query: 309 GG-VIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASA 367
GG + + +D D + D IG +V ++ + GH+
Sbjct: 221 GGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVD--------------FGHV---------- 256
Query: 368 TVSISDLSVNSLEDQKEREEIL--KRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGK 425
T DL E+Q++ +I RY P G L V ++ A+ L DV G
Sbjct: 257 TEEWRDLQSAEKEEQEKLGDICFSLRYVP--------TAGKLTVVILEAKNLKKMDVGGL 308
Query: 426 SDPFCVVEL--NNDRLLTH--TVYKN-LNPEWNKVFTFNI--KDIHSV-LEVTVYDEDRD 477
SDP+ + L N RL T+ KN LNP +N+ F+F + + I V + VTV D D+
Sbjct: 309 SDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKI 368
Query: 478 RSADFLGKVAI 488
D +GKV +
Sbjct: 369 GKNDAIGKVFV 379
Score = 57.0 bits (136), Expect = 7e-08
Identities = 36/103 (34%), Positives = 56/103 (54%), Gaps = 7/103 (6%)
Query: 249 GIVSITLIEGRDLKAMDSNGLSDPYVKFRLGH-----QKYKSKIMPKTLNPQWREQFDFH 303
G +++ ++E ++LK MD GLSDPYVK L +K K+ I TLNP + E F F
Sbjct: 288 GKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFE 347
Query: 304 L-YEERGGV-IDITAWDKDAGKRDDFIGRCQVDLSALSREQTH 344
+ +E+ V + +T D D ++D IG+ V ++ E H
Sbjct: 348 VPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRH 390
Score = 52.8 bits (125), Expect = 1e-06
Identities = 42/146 (28%), Positives = 71/146 (48%), Gaps = 7/146 (4%)
Query: 41 QLDITLRRGQSLAARDRGGTSDPYVKFKI--GGKEVFRSKIIHKNLNPVWEEKACILVDH 98
QL + + + L A D GGTSDPYVK + K+ F +K+ K LNPV+ E+ V +
Sbjct: 158 QLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPY 217
Query: 99 LR---EPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHD-LGII 154
+ L + V+D+D + D +G + + ++ T+ L+ + + LG I
Sbjct: 218 SELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDI 277
Query: 155 LLSVILTPKEGESRDVTMLMRKSWKR 180
S+ P G+ V +L K+ K+
Sbjct: 278 CFSLRYVPTAGK-LTVVILEAKNLKK 302
Score = 50.8 bits (120), Expect = 5e-06
Identities = 42/124 (33%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 380 EDQKEREEILK-RYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDR 438
E+ KE E++ K +YS F N + L V +I+A L A D+ G SDP+ V L D+
Sbjct: 135 EEPKEEEKLGKLQYSLDYDFQNNQ----LLVGIIQAAELPALDMGGTSDPYVKVFLLPDK 190
Query: 439 ---LLTHTVYKNLNPEWNKVFTFNIKDIH---SVLEVTVYDEDRDRSADFLGKVAIPLLS 492
T K LNP +N+ FTF + L + VYD DR D +G+ +P+ +
Sbjct: 191 KKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNT 250
Query: 493 IQNG 496
+ G
Sbjct: 251 VDFG 254
Score = 40.0 bits (92), Expect = 0.008
Identities = 37/126 (29%), Positives = 58/126 (46%), Gaps = 9/126 (7%)
Query: 37 PGMYQLDITLRRGQSLAARDRGGTSDPYVKFKI--GGKEVFRSK-IIHKN-LNPVWEEKA 92
P +L + + ++L D GG SDPYVK + GK + + K I KN LNP + E
Sbjct: 285 PTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESF 344
Query: 93 CILVDH---LREPLYIKVFDYDFGLQDDFMGSAFL--DLTQLELNRPTDVTLTLKDPHYP 147
V + + + V DYD ++D +G F+ + T EL +D+ + P
Sbjct: 345 SFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQ 404
Query: 148 DHDLGI 153
H L +
Sbjct: 405 WHTLQV 410
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 83.6 bits (205), Expect = 7e-16
Identities = 79/251 (31%), Positives = 119/251 (47%), Gaps = 47/251 (18%)
Query: 253 ITLIEGRDLKAMDSNGLSDPYVKFRL---GHQKYKSKIMPKTLNPQWREQFDFHL-YEER 308
+ +I+ +L A+D G SDPYVK L +K+++K+ KTLNP + EQF F + Y E
Sbjct: 161 VGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSEL 220
Query: 309 GG-VIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASA 367
GG + + +D D + D IG +V ++ + GH+
Sbjct: 221 GGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVD--------------FGHV---------- 256
Query: 368 TVSISDLSVNSLEDQKEREEIL--KRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGK 425
T DL E+Q++ +I RY P G L V ++ A+ L DV G
Sbjct: 257 TEEWRDLQSAEKEEQEKLGDICFSLRYVP--------TAGKLTVVILEAKNLKKMDVGGL 308
Query: 426 SDPFCVVEL--NNDRLLTH--TVYKN-LNPEWNKVFTFNI--KDIHSV-LEVTVYDEDRD 477
SDP+ + L N RL T+ KN LNP +N+ F+F + + I V + VTV D D+
Sbjct: 309 SDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKI 368
Query: 478 RSADFLGKVAI 488
D +GKV +
Sbjct: 369 GKNDAIGKVFV 379
Score = 57.0 bits (136), Expect = 7e-08
Identities = 36/103 (34%), Positives = 56/103 (54%), Gaps = 7/103 (6%)
Query: 249 GIVSITLIEGRDLKAMDSNGLSDPYVKFRLGH-----QKYKSKIMPKTLNPQWREQFDFH 303
G +++ ++E ++LK MD GLSDPYVK L +K K+ I TLNP + E F F
Sbjct: 288 GKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFE 347
Query: 304 L-YEERGGV-IDITAWDKDAGKRDDFIGRCQVDLSALSREQTH 344
+ +E+ V + +T D D ++D IG+ V ++ E H
Sbjct: 348 VPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRH 390
Score = 52.8 bits (125), Expect = 1e-06
Identities = 42/146 (28%), Positives = 71/146 (48%), Gaps = 7/146 (4%)
Query: 41 QLDITLRRGQSLAARDRGGTSDPYVKFKI--GGKEVFRSKIIHKNLNPVWEEKACILVDH 98
QL + + + L A D GGTSDPYVK + K+ F +K+ K LNPV+ E+ V +
Sbjct: 158 QLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPY 217
Query: 99 LR---EPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHD-LGII 154
+ L + V+D+D + D +G + + ++ T+ L+ + + LG I
Sbjct: 218 SELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDI 277
Query: 155 LLSVILTPKEGESRDVTMLMRKSWKR 180
S+ P G+ V +L K+ K+
Sbjct: 278 CFSLRYVPTAGK-LTVVILEAKNLKK 302
Score = 50.8 bits (120), Expect = 5e-06
Identities = 42/124 (33%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 380 EDQKEREEILK-RYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDR 438
E+ KE E++ K +YS F N + L V +I+A L A D+ G SDP+ V L D+
Sbjct: 135 EEPKEEEKLGKLQYSLDYDFQNNQ----LLVGIIQAAELPALDMGGTSDPYVKVFLLPDK 190
Query: 439 ---LLTHTVYKNLNPEWNKVFTFNIKDIH---SVLEVTVYDEDRDRSADFLGKVAIPLLS 492
T K LNP +N+ FTF + L + VYD DR D +G+ +P+ +
Sbjct: 191 KKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNT 250
Query: 493 IQNG 496
+ G
Sbjct: 251 VDFG 254
Score = 40.0 bits (92), Expect = 0.008
Identities = 37/126 (29%), Positives = 58/126 (46%), Gaps = 9/126 (7%)
Query: 37 PGMYQLDITLRRGQSLAARDRGGTSDPYVKFKI--GGKEVFRSK-IIHKN-LNPVWEEKA 92
P +L + + ++L D GG SDPYVK + GK + + K I KN LNP + E
Sbjct: 285 PTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESF 344
Query: 93 CILVDH---LREPLYIKVFDYDFGLQDDFMGSAFL--DLTQLELNRPTDVTLTLKDPHYP 147
V + + + V DYD ++D +G F+ + T EL +D+ + P
Sbjct: 345 SFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQ 404
Query: 148 DHDLGI 153
H L +
Sbjct: 405 WHTLQV 410
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 83.6 bits (205), Expect = 7e-16
Identities = 79/251 (31%), Positives = 119/251 (47%), Gaps = 47/251 (18%)
Query: 253 ITLIEGRDLKAMDSNGLSDPYVKFRL---GHQKYKSKIMPKTLNPQWREQFDFHL-YEER 308
+ +I+ +L A+D G SDPYVK L +K+++K+ KTLNP + EQF F + Y E
Sbjct: 161 VGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSEL 220
Query: 309 GG-VIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASA 367
GG + + +D D + D IG +V ++ + GH+
Sbjct: 221 GGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVD--------------FGHV---------- 256
Query: 368 TVSISDLSVNSLEDQKEREEIL--KRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGK 425
T DL E+Q++ +I RY P G L V ++ A+ L DV G
Sbjct: 257 TEEWRDLQSAEKEEQEKLGDICFSLRYVP--------TAGKLTVVILEAKNLKKMDVGGL 308
Query: 426 SDPFCVVEL--NNDRLLTH--TVYKN-LNPEWNKVFTFNI--KDIHSV-LEVTVYDEDRD 477
SDP+ + L N RL T+ KN LNP +N+ F+F + + I V + VTV D D+
Sbjct: 309 SDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKI 368
Query: 478 RSADFLGKVAI 488
D +GKV +
Sbjct: 369 GKNDAIGKVFV 379
Score = 57.0 bits (136), Expect = 7e-08
Identities = 36/103 (34%), Positives = 56/103 (54%), Gaps = 7/103 (6%)
Query: 249 GIVSITLIEGRDLKAMDSNGLSDPYVKFRLGH-----QKYKSKIMPKTLNPQWREQFDFH 303
G +++ ++E ++LK MD GLSDPYVK L +K K+ I TLNP + E F F
Sbjct: 288 GKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFE 347
Query: 304 L-YEERGGV-IDITAWDKDAGKRDDFIGRCQVDLSALSREQTH 344
+ +E+ V + +T D D ++D IG+ V ++ E H
Sbjct: 348 VPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRH 390
Score = 52.8 bits (125), Expect = 1e-06
Identities = 42/146 (28%), Positives = 71/146 (48%), Gaps = 7/146 (4%)
Query: 41 QLDITLRRGQSLAARDRGGTSDPYVKFKI--GGKEVFRSKIIHKNLNPVWEEKACILVDH 98
QL + + + L A D GGTSDPYVK + K+ F +K+ K LNPV+ E+ V +
Sbjct: 158 QLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPY 217
Query: 99 LR---EPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHD-LGII 154
+ L + V+D+D + D +G + + ++ T+ L+ + + LG I
Sbjct: 218 SELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDI 277
Query: 155 LLSVILTPKEGESRDVTMLMRKSWKR 180
S+ P G+ V +L K+ K+
Sbjct: 278 CFSLRYVPTAGK-LTVVILEAKNLKK 302
Score = 50.8 bits (120), Expect = 5e-06
Identities = 42/124 (33%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 380 EDQKEREEILK-RYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDR 438
E+ KE E++ K +YS F N + L V +I+A L A D+ G SDP+ V L D+
Sbjct: 135 EEPKEEEKLGKLQYSLDYDFQNNQ----LLVGIIQAAELPALDMGGTSDPYVKVFLLPDK 190
Query: 439 ---LLTHTVYKNLNPEWNKVFTFNIKDIH---SVLEVTVYDEDRDRSADFLGKVAIPLLS 492
T K LNP +N+ FTF + L + VYD DR D +G+ +P+ +
Sbjct: 191 KKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNT 250
Query: 493 IQNG 496
+ G
Sbjct: 251 VDFG 254
Score = 40.0 bits (92), Expect = 0.008
Identities = 37/126 (29%), Positives = 58/126 (46%), Gaps = 9/126 (7%)
Query: 37 PGMYQLDITLRRGQSLAARDRGGTSDPYVKFKI--GGKEVFRSK-IIHKN-LNPVWEEKA 92
P +L + + ++L D GG SDPYVK + GK + + K I KN LNP + E
Sbjct: 285 PTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESF 344
Query: 93 CILVDH---LREPLYIKVFDYDFGLQDDFMGSAFL--DLTQLELNRPTDVTLTLKDPHYP 147
V + + + V DYD ++D +G F+ + T EL +D+ + P
Sbjct: 345 SFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQ 404
Query: 148 DHDLGI 153
H L +
Sbjct: 405 WHTLQV 410
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 79.7 bits (195), Expect = 9e-15
Identities = 73/251 (29%), Positives = 119/251 (47%), Gaps = 43/251 (17%)
Query: 251 VSITLIEGRDLKAMDSNGLSDPYVKFRL---GHQKYKSKIMPKTLNPQWREQFDFHL-YE 306
+++ +++ +L A+D G SDPYVK L +KY++K+ KTLNP + E F F + Y+
Sbjct: 156 LTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQ 215
Query: 307 ERGG-VIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTA 365
E GG + + +D D + D IG +V ++ + Q + L+ GE
Sbjct: 216 ELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGE----------- 264
Query: 366 SATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGK 425
++E E++ + LR + G L V ++ A+ L DV G
Sbjct: 265 ----------------KEEPEKLGDICTSLRY---VPTAGKLTVCILEAKNLKKMDVGGL 305
Query: 426 SDPFCVVEL--NNDRL---LTHTVYKNLNPEWNKVFTFNI--KDIHSV-LEVTVYDEDRD 477
SDP+ + L N RL T K LNP +N+ F+F I + I V + VTV D D+
Sbjct: 306 SDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKL 365
Query: 478 RSADFLGKVAI 488
+ +GK+ +
Sbjct: 366 GKNEAIGKIFV 376
Score = 57.4 bits (137), Expect = 5e-08
Identities = 36/103 (34%), Positives = 57/103 (55%), Gaps = 7/103 (6%)
Query: 249 GIVSITLIEGRDLKAMDSNGLSDPYVKFRLGH-----QKYKSKIMPKTLNPQWREQFDFH 303
G +++ ++E ++LK MD GLSDPYVK L +K K+ + KTLNP + E F F
Sbjct: 285 GKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFE 344
Query: 304 L-YEERGGV-IDITAWDKDAGKRDDFIGRCQVDLSALSREQTH 344
+ +E+ V + +T D D +++ IG+ V +A E H
Sbjct: 345 IPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRH 387
Score = 51.6 bits (122), Expect = 3e-06
Identities = 40/146 (27%), Positives = 71/146 (48%), Gaps = 7/146 (4%)
Query: 41 QLDITLRRGQSLAARDRGGTSDPYVKFKI--GGKEVFRSKIIHKNLNPVWEEKACILVDH 98
QL + + + L A D GGTSDPYVK + K+ + +K+ K LNP + E V +
Sbjct: 155 QLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPY 214
Query: 99 LR---EPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHD-LGII 154
+ L + ++D+D + D +G + + ++L +P + L+ + + LG I
Sbjct: 215 QELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDI 274
Query: 155 LLSVILTPKEGESRDVTMLMRKSWKR 180
S+ P G+ V +L K+ K+
Sbjct: 275 CTSLRYVPTAGK-LTVCILEAKNLKK 299
Score = 50.8 bits (120), Expect = 5e-06
Identities = 39/124 (31%), Positives = 59/124 (47%), Gaps = 9/124 (7%)
Query: 380 EDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRL 439
E++KE E + K L L V V++A L A D+ G SDP+ V L D+
Sbjct: 132 EEEKEPENLGKLQFSLDYDFQANQ---LTVGVLQAAELPALDMGGTSDPYVKVFLLPDKK 188
Query: 440 L---THTVYKNLNPEWNKVFTFNIKDIH---SVLEVTVYDEDRDRSADFLGKVAIPLLSI 493
T K LNP +N+ FTF + L + +YD DR D +G+V +P+ ++
Sbjct: 189 KKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTV 248
Query: 494 QNGE 497
G+
Sbjct: 249 DLGQ 252
Score = 38.1 bits (87), Expect = 0.031
Identities = 33/124 (26%), Positives = 56/124 (45%), Gaps = 9/124 (7%)
Query: 37 PGMYQLDITLRRGQSLAARDRGGTSDPYVKFKI--GGKEVFRSK--IIHKNLNPVWEEKA 92
P +L + + ++L D GG SDPYVK + GK + + K + K LNP + E
Sbjct: 282 PTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESF 341
Query: 93 CILVDH---LREPLYIKVFDYDFGLQDDFMGSAFL--DLTQLELNRPTDVTLTLKDPHYP 147
+ + + + V DYD +++ +G F+ + T EL +D+ + P
Sbjct: 342 SFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQ 401
Query: 148 DHDL 151
H L
Sbjct: 402 WHSL 405
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 79.7 bits (195), Expect = 9e-15
Identities = 73/251 (29%), Positives = 119/251 (47%), Gaps = 43/251 (17%)
Query: 251 VSITLIEGRDLKAMDSNGLSDPYVKFRL---GHQKYKSKIMPKTLNPQWREQFDFHL-YE 306
+++ +++ +L A+D G SDPYVK L +KY++K+ KTLNP + E F F + Y+
Sbjct: 156 LTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQ 215
Query: 307 ERGG-VIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTA 365
E GG + + +D D + D IG +V ++ + Q + L+ GE
Sbjct: 216 ELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGE----------- 264
Query: 366 SATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGK 425
++E E++ + LR + G L V ++ A+ L DV G
Sbjct: 265 ----------------KEEPEKLGDICTSLRY---VPTAGKLTVCILEAKNLKKMDVGGL 305
Query: 426 SDPFCVVEL--NNDRL---LTHTVYKNLNPEWNKVFTFNI--KDIHSV-LEVTVYDEDRD 477
SDP+ + L N RL T K LNP +N+ F+F I + I V + VTV D D+
Sbjct: 306 SDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKL 365
Query: 478 RSADFLGKVAI 488
+ +GK+ +
Sbjct: 366 GKNEAIGKIFV 376
Score = 57.4 bits (137), Expect = 5e-08
Identities = 36/103 (34%), Positives = 57/103 (55%), Gaps = 7/103 (6%)
Query: 249 GIVSITLIEGRDLKAMDSNGLSDPYVKFRLGH-----QKYKSKIMPKTLNPQWREQFDFH 303
G +++ ++E ++LK MD GLSDPYVK L +K K+ + KTLNP + E F F
Sbjct: 285 GKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFE 344
Query: 304 L-YEERGGV-IDITAWDKDAGKRDDFIGRCQVDLSALSREQTH 344
+ +E+ V + +T D D +++ IG+ V +A E H
Sbjct: 345 IPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRH 387
Score = 51.6 bits (122), Expect = 3e-06
Identities = 40/146 (27%), Positives = 71/146 (48%), Gaps = 7/146 (4%)
Query: 41 QLDITLRRGQSLAARDRGGTSDPYVKFKI--GGKEVFRSKIIHKNLNPVWEEKACILVDH 98
QL + + + L A D GGTSDPYVK + K+ + +K+ K LNP + E V +
Sbjct: 155 QLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPY 214
Query: 99 LR---EPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHD-LGII 154
+ L + ++D+D + D +G + + ++L +P + L+ + + LG I
Sbjct: 215 QELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDI 274
Query: 155 LLSVILTPKEGESRDVTMLMRKSWKR 180
S+ P G+ V +L K+ K+
Sbjct: 275 CTSLRYVPTAGK-LTVCILEAKNLKK 299
Score = 50.8 bits (120), Expect = 5e-06
Identities = 39/124 (31%), Positives = 59/124 (47%), Gaps = 9/124 (7%)
Query: 380 EDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRL 439
E++KE E + K L L V V++A L A D+ G SDP+ V L D+
Sbjct: 132 EEEKEPENLGKLQFSLDYDFQANQ---LTVGVLQAAELPALDMGGTSDPYVKVFLLPDKK 188
Query: 440 L---THTVYKNLNPEWNKVFTFNIKDIH---SVLEVTVYDEDRDRSADFLGKVAIPLLSI 493
T K LNP +N+ FTF + L + +YD DR D +G+V +P+ ++
Sbjct: 189 KKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTV 248
Query: 494 QNGE 497
G+
Sbjct: 249 DLGQ 252
Score = 38.1 bits (87), Expect = 0.031
Identities = 33/124 (26%), Positives = 56/124 (45%), Gaps = 9/124 (7%)
Query: 37 PGMYQLDITLRRGQSLAARDRGGTSDPYVKFKI--GGKEVFRSK--IIHKNLNPVWEEKA 92
P +L + + ++L D GG SDPYVK + GK + + K + K LNP + E
Sbjct: 282 PTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESF 341
Query: 93 CILVDH---LREPLYIKVFDYDFGLQDDFMGSAFL--DLTQLELNRPTDVTLTLKDPHYP 147
+ + + + V DYD +++ +G F+ + T EL +D+ + P
Sbjct: 342 SFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQ 401
Query: 148 DHDL 151
H L
Sbjct: 402 WHSL 405
>gi|45387945 family with sequence similarity 62 (C2 domain
containing) member B [Homo sapiens]
Length = 893
Score = 79.0 bits (193), Expect = 2e-14
Identities = 69/261 (26%), Positives = 121/261 (46%), Gaps = 28/261 (10%)
Query: 248 RGIVSITLIEGRDLKAMDS------NGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFD 301
+G++ I IE +DL+ D+ G SDPY R+G+Q ++S+++ + L+P+W E ++
Sbjct: 356 KGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYE 415
Query: 302 FHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEE---GEGHLV 358
+YE G ++I +D+D K DDF+G +DL + +E+ L+E G+ HL
Sbjct: 416 ALVYEHPGQELEIELFDEDPDK-DDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHL- 473
Query: 359 LLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLM 418
L LT S D + ++ K++ ++ L + + A L
Sbjct: 474 RLEWLTLMPNASNLDKVLTDIKADKDQA------------NDGLSSALLILYLDSARNLP 521
Query: 419 AA-DVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD-IHSVLEVTVYDEDR 476
+ ++ +P + + + + YK P W + FTF I + LEV V DE
Sbjct: 522 SGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQH 581
Query: 477 DRSADFLGKVAIPLLSIQNGE 497
S LG + +PL + E
Sbjct: 582 QCS---LGNLKVPLSQLLTSE 599
Score = 58.2 bits (139), Expect = 3e-08
Identities = 32/86 (37%), Positives = 53/86 (61%), Gaps = 3/86 (3%)
Query: 59 GTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEE-KACILVDHLREPLYIKVFDYDFGLQDD 117
G SDPY ++G ++F+S++I +NL+P W E ++ +H + L I++FD D +DD
Sbjct: 382 GKSDPYGIIRVGN-QIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPD-KDD 439
Query: 118 FMGSAFLDLTQLELNRPTDVTLTLKD 143
F+GS +DL ++E R D TL +
Sbjct: 440 FLGSLMIDLIEVEKERLLDEWFTLDE 465
Score = 38.5 bits (88), Expect = 0.024
Identities = 27/91 (29%), Positives = 44/91 (48%), Gaps = 7/91 (7%)
Query: 262 KAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDKDA 321
K + SN +P V+ +GH+ +SKI KT P W E F F ++ + +++ D+
Sbjct: 524 KKISSN--PNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDE-- 579
Query: 322 GKRDDFIGRCQVDLSAL--SREQTHKLELQL 350
+ +G +V LS L S + T QL
Sbjct: 580 -QHQCSLGNLKVPLSQLLTSEDMTVSQRFQL 609
Score = 31.2 bits (69), Expect = 3.8
Identities = 20/49 (40%), Positives = 27/49 (55%), Gaps = 6/49 (12%)
Query: 259 RDLKAMDSNGLSDPYVKFRLGHQKYKS-----KIMPKTLNPQWREQFDF 302
R+L A +G SDPYV+ L K +S + KTLNP + + FDF
Sbjct: 783 RNLIAFSEDG-SDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDF 830
>gi|92859638 synaptotagmin V [Homo sapiens]
Length = 386
Score = 76.3 bits (186), Expect = 1e-13
Identities = 73/255 (28%), Positives = 118/255 (46%), Gaps = 47/255 (18%)
Query: 249 GIVSITLIEGRDLKAMDSNGLSDPYVKFRL---GHQKYKSKIMPKTLNPQWREQFDFHL- 304
G + + +++ L A+D G SDPYV+ L ++Y++K+ +TLNP + E F F +
Sbjct: 123 GQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVP 182
Query: 305 YEERGG-VIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTL 363
Y E GG V+ + +D D R+D IG +V +S++
Sbjct: 183 YVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVD------------------------ 218
Query: 364 TASATVSISDLSVNSLEDQKEREEIL--KRYSPLRIFHNLKDVGFLQVKVIRAEGLMAAD 421
+ +L E+Q++ +I RY P G L V V+ A+ L D
Sbjct: 219 LGRPVQAWRELQAAPREEQEKLGDICFSLRYVP--------TAGKLTVIVLEAKNLKKMD 270
Query: 422 VTGKSDPFCVVEL----NNDRLLTHTVYKN-LNPEWNKVFTFNI--KDIHSV-LEVTVYD 473
V G SDP+ V L R T+ KN LNP +N+ F+F + + V +E+TV D
Sbjct: 271 VGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLD 330
Query: 474 EDRDRSADFLGKVAI 488
D+ + +G+VA+
Sbjct: 331 YDKLGKNEAIGRVAV 345
Score = 53.5 bits (127), Expect = 7e-07
Identities = 35/98 (35%), Positives = 51/98 (52%), Gaps = 6/98 (6%)
Query: 405 GFLQVKVIRAEGLMAADVTGKSDPFCVVELNND---RLLTHTVYKNLNPEWNKVFTFNIK 461
G L V +++A GL A D+ G SDP+ V L D R T + LNP + + F F +
Sbjct: 123 GQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVP 182
Query: 462 DIH---SVLEVTVYDEDRDRSADFLGKVAIPLLSIQNG 496
+ VL + VYD DR D +G+V +P+ S+ G
Sbjct: 183 YVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLG 220
Score = 53.1 bits (126), Expect = 9e-07
Identities = 33/96 (34%), Positives = 53/96 (55%), Gaps = 7/96 (7%)
Query: 249 GIVSITLIEGRDLKAMDSNGLSDPYVKFRLGH-----QKYKSKIMPKTLNPQWREQFDFH 303
G +++ ++E ++LK MD GLSDPYVK L +K K+ I TLNP + E F F
Sbjct: 254 GKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFE 313
Query: 304 L--YEERGGVIDITAWDKDAGKRDDFIGRCQVDLSA 337
+ + + +++T D D +++ IGR V +A
Sbjct: 314 VPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAA 349
Score = 51.2 bits (121), Expect = 4e-06
Identities = 40/146 (27%), Positives = 71/146 (48%), Gaps = 7/146 (4%)
Query: 41 QLDITLRRGQSLAARDRGGTSDPYVKFKI--GGKEVFRSKIIHKNLNPVWEEKACILVDH 98
QL + + + LAA D GG+SDPYV+ + + + +K+ + LNP + E V +
Sbjct: 124 QLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVPY 183
Query: 99 LR---EPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLK-DPHYPDHDLGII 154
+ L + V+D+D ++D +G + ++ ++L RP L+ P LG I
Sbjct: 184 VELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQEKLGDI 243
Query: 155 LLSVILTPKEGESRDVTMLMRKSWKR 180
S+ P G+ V +L K+ K+
Sbjct: 244 CFSLRYVPTAGK-LTVIVLEAKNLKK 268
Score = 37.0 bits (84), Expect = 0.070
Identities = 30/82 (36%), Positives = 44/82 (53%), Gaps = 7/82 (8%)
Query: 37 PGMYQLDITLRRGQSLAARDRGGTSDPYVKFKI--GGKEVFRSK-IIHKN-LNPVWEEKA 92
P +L + + ++L D GG SDPYVK + GGK+V + K I KN LNP + E
Sbjct: 251 PTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAF 310
Query: 93 CILV--DHLRE-PLYIKVFDYD 111
V D +++ + + V DYD
Sbjct: 311 SFEVPCDQVQKVQVELTVLDYD 332
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 72.4 bits (176), Expect = 2e-12
Identities = 59/206 (28%), Positives = 92/206 (44%), Gaps = 28/206 (13%)
Query: 253 ITLIEGRDLKAMDSNGLSDPYVKFRL-----GHQKYKSKIMPKTLNPQWREQFDFHLY-E 306
+T+ + ++L MD NGLSDPYVK +L K K+K + TLNPQW E F F L
Sbjct: 175 VTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPS 234
Query: 307 ERGGVIDITAWDKDAGKRDDFIGRCQVDLS------------ALSREQTHKLELQLEEG- 353
++ + + WD D R+DF+G +S L++E+ + + EG
Sbjct: 235 DKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGD 294
Query: 354 -EGHLVLLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVI 412
EG++ L + + ++ ED+K+ L R L D FL V
Sbjct: 295 EEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRV-------KLTDFNFLMVLGK 347
Query: 413 RAEG-LMAADVTGKSDPFCVVELNND 437
+ G +M AD G + + + L D
Sbjct: 348 GSFGKVMLADRKGTEELYAIKILKKD 373
Score = 54.7 bits (130), Expect = 3e-07
Identities = 32/88 (36%), Positives = 47/88 (53%), Gaps = 7/88 (7%)
Query: 407 LQVKVIRAEGLMAADVTGKSDPFCVVEL-----NNDRLLTHTVYKNLNPEWNKVFTFNIK 461
L V V A+ L+ D G SDP+ ++L N + T T+ LNP+WN+ FTF +K
Sbjct: 173 LHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLK 232
Query: 462 --DIHSVLEVTVYDEDRDRSADFLGKVA 487
D L V ++D DR DF+G ++
Sbjct: 233 PSDKDRRLSVEIWDWDRTTRNDFMGSLS 260
Score = 53.9 bits (128), Expect = 6e-07
Identities = 37/137 (27%), Positives = 64/137 (46%), Gaps = 13/137 (9%)
Query: 3 DSCKL----KSACNLPFICNKKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRG 58
D+C + + N+P +C G + +AD +L +T+R ++L D
Sbjct: 133 DTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADE---KLHVTVRDAKNLIPMDPN 189
Query: 59 GTSDPYVKFKI----GGKEVFRSKIIHKNLNPVWEEKACILV--DHLREPLYIKVFDYDF 112
G SDPYVK K+ + ++K I LNP W E + L ++++D+D
Sbjct: 190 GLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDR 249
Query: 113 GLQDDFMGSAFLDLTQL 129
++DFMGS +++L
Sbjct: 250 TTRNDFMGSLSFGVSEL 266
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 72.4 bits (176), Expect = 2e-12
Identities = 44/128 (34%), Positives = 69/128 (53%), Gaps = 10/128 (7%)
Query: 236 RLSDLHRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFRL-----GHQKYKSKIMPK 290
R ++ ++H+ R ++ + + + ++L MD NGLSDPYVK +L K K+K +
Sbjct: 158 RRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKC 217
Query: 291 TLNPQWREQFDFHLYE-ERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQT---HKL 346
+LNP+W E F F L E ++ + + WD D R+DF+G +S L + KL
Sbjct: 218 SLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKL 277
Query: 347 ELQLEEGE 354
L EEGE
Sbjct: 278 -LSQEEGE 284
Score = 52.0 bits (123), Expect = 2e-06
Identities = 49/177 (27%), Positives = 74/177 (41%), Gaps = 21/177 (11%)
Query: 403 DVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNND-----RLLTHTVYKNLNPEWNKVFT 457
D L V V A+ L+ D G SDP+ ++L D + T T+ +LNPEWN+ F
Sbjct: 169 DRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFR 228
Query: 458 FNIK--DIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTG----- 510
F +K D L V ++D D DF+G ++ + +Q + Q G
Sbjct: 229 FQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNV 288
Query: 511 ---PTKGVIYLEIDVIFNAVKASLRTLIPKEQ------KYIEEENRLSKQLLLRNFI 558
P E+ F K S T +P+E+ K+ NR +L NF+
Sbjct: 289 PVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFL 345
Score = 46.6 bits (109), Expect = 9e-05
Identities = 28/95 (29%), Positives = 50/95 (52%), Gaps = 6/95 (6%)
Query: 42 LDITLRRGQSLAARDRGGTSDPYVKFKI----GGKEVFRSKIIHKNLNPVWEE--KACIL 95
L + +R ++L D G SDPYVK K+ + ++K I +LNP W E + +
Sbjct: 173 LIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232
Query: 96 VDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLE 130
L ++++D+D ++DFMGS +++L+
Sbjct: 233 ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQ 267
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 72.4 bits (176), Expect = 2e-12
Identities = 44/128 (34%), Positives = 69/128 (53%), Gaps = 10/128 (7%)
Query: 236 RLSDLHRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFRL-----GHQKYKSKIMPK 290
R ++ ++H+ R ++ + + + ++L MD NGLSDPYVK +L K K+K +
Sbjct: 158 RRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKC 217
Query: 291 TLNPQWREQFDFHLYE-ERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQT---HKL 346
+LNP+W E F F L E ++ + + WD D R+DF+G +S L + KL
Sbjct: 218 SLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKL 277
Query: 347 ELQLEEGE 354
L EEGE
Sbjct: 278 -LSQEEGE 284
Score = 52.0 bits (123), Expect = 2e-06
Identities = 49/177 (27%), Positives = 74/177 (41%), Gaps = 21/177 (11%)
Query: 403 DVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNND-----RLLTHTVYKNLNPEWNKVFT 457
D L V V A+ L+ D G SDP+ ++L D + T T+ +LNPEWN+ F
Sbjct: 169 DRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFR 228
Query: 458 FNIK--DIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTG----- 510
F +K D L V ++D D DF+G ++ + +Q + Q G
Sbjct: 229 FQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNV 288
Query: 511 ---PTKGVIYLEIDVIFNAVKASLRTLIPKEQ------KYIEEENRLSKQLLLRNFI 558
P E+ F K S T +P+E+ K+ NR +L NF+
Sbjct: 289 PVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFL 345
Score = 46.6 bits (109), Expect = 9e-05
Identities = 28/95 (29%), Positives = 50/95 (52%), Gaps = 6/95 (6%)
Query: 42 LDITLRRGQSLAARDRGGTSDPYVKFKI----GGKEVFRSKIIHKNLNPVWEE--KACIL 95
L + +R ++L D G SDPYVK K+ + ++K I +LNP W E + +
Sbjct: 173 LIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLK 232
Query: 96 VDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLE 130
L ++++D+D ++DFMGS +++L+
Sbjct: 233 ESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQ 267
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 71.6 bits (174), Expect = 3e-12
Identities = 34/104 (32%), Positives = 58/104 (55%), Gaps = 4/104 (3%)
Query: 239 DLHRKSHLWRGI----VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNP 294
++H + +W G + +++E RDL D NG SDP+V+ R + ++ I+ K+ P
Sbjct: 47 EIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYP 106
Query: 295 QWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSAL 338
+W E F+F L E + + AWD D R+DF+G+ +D+ L
Sbjct: 107 RWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRL 150
Score = 50.8 bits (120), Expect = 5e-06
Identities = 38/139 (27%), Positives = 69/139 (49%), Gaps = 14/139 (10%)
Query: 41 QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEK-ACILVDHL 99
+L ++ + LA +DR GTSDP+V+ + G+ + I+ K+ P W E L +
Sbjct: 62 RLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFELQEGA 120
Query: 100 REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTL-----KDPHYPDHDLGII 154
E L ++ +D+D ++DF+G +D+ +L + + + L K + + +LG +
Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
Query: 155 LLSVILTPKEGESRDVTML 173
L V L RD T+L
Sbjct: 181 QLEVRL-------RDETVL 192
Score = 47.8 bits (112), Expect = 4e-05
Identities = 31/94 (32%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Query: 407 LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD-IHS 465
L+ V+ A L D G SDPF V T V K+ P WN+ F F +++
Sbjct: 63 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 122
Query: 466 VLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQK 499
L V +D D DFLGKV I + ++ +Q+
Sbjct: 123 ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 71.6 bits (174), Expect = 3e-12
Identities = 34/104 (32%), Positives = 58/104 (55%), Gaps = 4/104 (3%)
Query: 239 DLHRKSHLWRGI----VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNP 294
++H + +W G + +++E RDL D NG SDP+V+ R + ++ I+ K+ P
Sbjct: 119 EIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYP 178
Query: 295 QWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSAL 338
+W E F+F L E + + AWD D R+DF+G+ +D+ L
Sbjct: 179 RWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRL 222
Score = 70.1 bits (170), Expect = 7e-12
Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 49/263 (18%)
Query: 248 RGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKY-KSKIMPKTLNPQWREQFDFHLYE 306
R + I ++EG++L A D G SDPY ++ ++ ++ + KTL P W E++ HL
Sbjct: 4 RSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPP 63
Query: 307 ERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQ------THKLELQLEE---GEGHL 357
V D+DA RDD IG+ + ++ H E+ +E GE HL
Sbjct: 64 TFHAVA-FYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHL 122
Query: 358 VLLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGL 417
L V A A L+ V+ A L
Sbjct: 123 RLEVWPGARACR-------------------------------------LRCSVLEARDL 145
Query: 418 MAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD-IHSVLEVTVYDEDR 476
D G SDPF V T V K+ P WN+ F F +++ L V +D D
Sbjct: 146 APKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDL 205
Query: 477 DRSADFLGKVAIPLLSIQNGEQK 499
DFLGKV I + ++ +Q+
Sbjct: 206 VSRNDFLGKVVIDVQRLRVVQQE 228
Score = 50.8 bits (120), Expect = 5e-06
Identities = 38/139 (27%), Positives = 69/139 (49%), Gaps = 14/139 (10%)
Query: 41 QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEK-ACILVDHL 99
+L ++ + LA +DR GTSDP+V+ + G+ + I+ K+ P W E L +
Sbjct: 134 RLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFELQEGA 192
Query: 100 REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTL-----KDPHYPDHDLGII 154
E L ++ +D+D ++DF+G +D+ +L + + + L K + + +LG +
Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252
Query: 155 LLSVILTPKEGESRDVTML 173
L V L RD T+L
Sbjct: 253 QLEVRL-------RDETVL 264
Score = 43.5 bits (101), Expect = 7e-04
Identities = 25/83 (30%), Positives = 41/83 (49%)
Query: 42 LDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLRE 101
L I + G++L A+D G+SDPY K+ + + R+ + K L P W E+ + +
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 102 PLYIKVFDYDFGLQDDFMGSAFL 124
+ V D D +DD +G L
Sbjct: 67 AVAFYVMDEDALSRDDVIGKVCL 89
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 71.6 bits (174), Expect = 3e-12
Identities = 34/104 (32%), Positives = 58/104 (55%), Gaps = 4/104 (3%)
Query: 239 DLHRKSHLWRGI----VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNP 294
++H + +W G + +++E RDL D NG SDP+V+ R + ++ I+ K+ P
Sbjct: 47 EIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYP 106
Query: 295 QWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSAL 338
+W E F+F L E + + AWD D R+DF+G+ +D+ L
Sbjct: 107 RWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRL 150
Score = 50.8 bits (120), Expect = 5e-06
Identities = 38/139 (27%), Positives = 69/139 (49%), Gaps = 14/139 (10%)
Query: 41 QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEK-ACILVDHL 99
+L ++ + LA +DR GTSDP+V+ + G+ + I+ K+ P W E L +
Sbjct: 62 RLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFELQEGA 120
Query: 100 REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTL-----KDPHYPDHDLGII 154
E L ++ +D+D ++DF+G +D+ +L + + + L K + + +LG +
Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
Query: 155 LLSVILTPKEGESRDVTML 173
L V L RD T+L
Sbjct: 181 QLEVRL-------RDETVL 192
Score = 47.8 bits (112), Expect = 4e-05
Identities = 31/94 (32%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Query: 407 LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD-IHS 465
L+ V+ A L D G SDPF V T V K+ P WN+ F F +++
Sbjct: 63 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 122
Query: 466 VLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQK 499
L V +D D DFLGKV I + ++ +Q+
Sbjct: 123 ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 71.6 bits (174), Expect = 3e-12
Identities = 34/104 (32%), Positives = 58/104 (55%), Gaps = 4/104 (3%)
Query: 239 DLHRKSHLWRGI----VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNP 294
++H + +W G + +++E RDL D NG SDP+V+ R + ++ I+ K+ P
Sbjct: 119 EIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYP 178
Query: 295 QWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSAL 338
+W E F+F L E + + AWD D R+DF+G+ +D+ L
Sbjct: 179 RWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRL 222
Score = 70.1 bits (170), Expect = 7e-12
Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 49/263 (18%)
Query: 248 RGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKY-KSKIMPKTLNPQWREQFDFHLYE 306
R + I ++EG++L A D G SDPY ++ ++ ++ + KTL P W E++ HL
Sbjct: 4 RSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPP 63
Query: 307 ERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQ------THKLELQLEE---GEGHL 357
V D+DA RDD IG+ + ++ H E+ +E GE HL
Sbjct: 64 TFHAVA-FYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHL 122
Query: 358 VLLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGL 417
L V A A L+ V+ A L
Sbjct: 123 RLEVWPGARACR-------------------------------------LRCSVLEARDL 145
Query: 418 MAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD-IHSVLEVTVYDEDR 476
D G SDPF V T V K+ P WN+ F F +++ L V +D D
Sbjct: 146 APKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDL 205
Query: 477 DRSADFLGKVAIPLLSIQNGEQK 499
DFLGKV I + ++ +Q+
Sbjct: 206 VSRNDFLGKVVIDVQRLRVVQQE 228
Score = 50.8 bits (120), Expect = 5e-06
Identities = 38/139 (27%), Positives = 69/139 (49%), Gaps = 14/139 (10%)
Query: 41 QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEK-ACILVDHL 99
+L ++ + LA +DR GTSDP+V+ + G+ + I+ K+ P W E L +
Sbjct: 134 RLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFELQEGA 192
Query: 100 REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTL-----KDPHYPDHDLGII 154
E L ++ +D+D ++DF+G +D+ +L + + + L K + + +LG +
Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252
Query: 155 LLSVILTPKEGESRDVTML 173
L V L RD T+L
Sbjct: 253 QLEVRL-------RDETVL 264
Score = 43.5 bits (101), Expect = 7e-04
Identities = 25/83 (30%), Positives = 41/83 (49%)
Query: 42 LDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLRE 101
L I + G++L A+D G+SDPY K+ + + R+ + K L P W E+ + +
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 102 PLYIKVFDYDFGLQDDFMGSAFL 124
+ V D D +DD +G L
Sbjct: 67 AVAFYVMDEDALSRDDVIGKVCL 89
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 71.6 bits (174), Expect = 3e-12
Identities = 34/104 (32%), Positives = 58/104 (55%), Gaps = 4/104 (3%)
Query: 239 DLHRKSHLWRGI----VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNP 294
++H + +W G + +++E RDL D NG SDP+V+ R + ++ I+ K+ P
Sbjct: 119 EIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYP 178
Query: 295 QWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSAL 338
+W E F+F L E + + AWD D R+DF+G+ +D+ L
Sbjct: 179 RWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRL 222
Score = 70.1 bits (170), Expect = 7e-12
Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 49/263 (18%)
Query: 248 RGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKY-KSKIMPKTLNPQWREQFDFHLYE 306
R + I ++EG++L A D G SDPY ++ ++ ++ + KTL P W E++ HL
Sbjct: 4 RSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPP 63
Query: 307 ERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQ------THKLELQLEE---GEGHL 357
V D+DA RDD IG+ + ++ H E+ +E GE HL
Sbjct: 64 TFHAVA-FYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHL 122
Query: 358 VLLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGL 417
L V A A L+ V+ A L
Sbjct: 123 RLEVWPGARACR-------------------------------------LRCSVLEARDL 145
Query: 418 MAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD-IHSVLEVTVYDEDR 476
D G SDPF V T V K+ P WN+ F F +++ L V +D D
Sbjct: 146 APKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDL 205
Query: 477 DRSADFLGKVAIPLLSIQNGEQK 499
DFLGKV I + ++ +Q+
Sbjct: 206 VSRNDFLGKVVIDVQRLRVVQQE 228
Score = 50.8 bits (120), Expect = 5e-06
Identities = 38/139 (27%), Positives = 69/139 (49%), Gaps = 14/139 (10%)
Query: 41 QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEK-ACILVDHL 99
+L ++ + LA +DR GTSDP+V+ + G+ + I+ K+ P W E L +
Sbjct: 134 RLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFELQEGA 192
Query: 100 REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTL-----KDPHYPDHDLGII 154
E L ++ +D+D ++DF+G +D+ +L + + + L K + + +LG +
Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252
Query: 155 LLSVILTPKEGESRDVTML 173
L V L RD T+L
Sbjct: 253 QLEVRL-------RDETVL 264
Score = 43.5 bits (101), Expect = 7e-04
Identities = 25/83 (30%), Positives = 41/83 (49%)
Query: 42 LDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLRE 101
L I + G++L A+D G+SDPY K+ + + R+ + K L P W E+ + +
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 102 PLYIKVFDYDFGLQDDFMGSAFL 124
+ V D D +DD +G L
Sbjct: 67 AVAFYVMDEDALSRDDVIGKVCL 89
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 71.6 bits (174), Expect = 3e-12
Identities = 34/104 (32%), Positives = 58/104 (55%), Gaps = 4/104 (3%)
Query: 239 DLHRKSHLWRGI----VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNP 294
++H + +W G + +++E RDL D NG SDP+V+ R + ++ I+ K+ P
Sbjct: 119 EIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYP 178
Query: 295 QWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSAL 338
+W E F+F L E + + AWD D R+DF+G+ +D+ L
Sbjct: 179 RWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRL 222
Score = 70.1 bits (170), Expect = 7e-12
Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 49/263 (18%)
Query: 248 RGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKY-KSKIMPKTLNPQWREQFDFHLYE 306
R + I ++EG++L A D G SDPY ++ ++ ++ + KTL P W E++ HL
Sbjct: 4 RSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPP 63
Query: 307 ERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQ------THKLELQLEE---GEGHL 357
V D+DA RDD IG+ + ++ H E+ +E GE HL
Sbjct: 64 TFHAVA-FYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHL 122
Query: 358 VLLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGL 417
L V A A L+ V+ A L
Sbjct: 123 RLEVWPGARACR-------------------------------------LRCSVLEARDL 145
Query: 418 MAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD-IHSVLEVTVYDEDR 476
D G SDPF V T V K+ P WN+ F F +++ L V +D D
Sbjct: 146 APKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDL 205
Query: 477 DRSADFLGKVAIPLLSIQNGEQK 499
DFLGKV I + ++ +Q+
Sbjct: 206 VSRNDFLGKVVIDVQRLRVVQQE 228
Score = 50.8 bits (120), Expect = 5e-06
Identities = 38/139 (27%), Positives = 69/139 (49%), Gaps = 14/139 (10%)
Query: 41 QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEK-ACILVDHL 99
+L ++ + LA +DR GTSDP+V+ + G+ + I+ K+ P W E L +
Sbjct: 134 RLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFELQEGA 192
Query: 100 REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTL-----KDPHYPDHDLGII 154
E L ++ +D+D ++DF+G +D+ +L + + + L K + + +LG +
Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252
Query: 155 LLSVILTPKEGESRDVTML 173
L V L RD T+L
Sbjct: 253 QLEVRL-------RDETVL 264
Score = 43.5 bits (101), Expect = 7e-04
Identities = 25/83 (30%), Positives = 41/83 (49%)
Query: 42 LDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLRE 101
L I + G++L A+D G+SDPY K+ + + R+ + K L P W E+ + +
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 102 PLYIKVFDYDFGLQDDFMGSAFL 124
+ V D D +DD +G L
Sbjct: 67 AVAFYVMDEDALSRDDVIGKVCL 89
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 71.6 bits (174), Expect = 3e-12
Identities = 45/144 (31%), Positives = 73/144 (50%), Gaps = 7/144 (4%)
Query: 381 DQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLL 440
++K+RE+ + S +G L V VI A L A GKS+P+C + + +
Sbjct: 1523 EKKKREKAYQARS-----QKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYT 1577
Query: 441 THTVYKNLNPEWNKVFTFNIKDIH-SVLEVTVYDEDRDRSADFLGKVAIPLLSIQ-NGEQ 498
T T+ LNP+WN F IKD++ VL +T++D D+ DFLG+ IP+ I+ E
Sbjct: 1578 TRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQES 1637
Query: 499 KAYVLKNKQLTGPTKGVIYLEIDV 522
K + + L G +++ D+
Sbjct: 1638 KGPMTRRLLLHEVPTGEVWVRFDL 1661
Score = 68.6 bits (166), Expect = 2e-11
Identities = 32/97 (32%), Positives = 55/97 (56%)
Query: 249 GIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEER 308
G + + +IE +LKA NG S+PY + +G Q Y ++ + TLNP+W F + +
Sbjct: 1542 GRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLY 1601
Query: 309 GGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHK 345
V+ +T +D+D DDF+GR ++ ++ + EQ K
Sbjct: 1602 QDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESK 1638
Score = 37.7 bits (86), Expect = 0.041
Identities = 24/104 (23%), Positives = 48/104 (46%), Gaps = 2/104 (1%)
Query: 38 GMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVD 97
G+ +L + + L A G S+PY + +G + + ++ I LNP W +
Sbjct: 1540 GIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQS-YTTRTIQDTLNPKWNFNCQFFIK 1598
Query: 98 HL-REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLT 140
L ++ L + +FD D DDF+G + + ++ + + +T
Sbjct: 1599 DLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMT 1642
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 71.6 bits (174), Expect = 3e-12
Identities = 45/144 (31%), Positives = 73/144 (50%), Gaps = 7/144 (4%)
Query: 381 DQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLL 440
++K+RE+ + S +G L V VI A L A GKS+P+C + + +
Sbjct: 1550 EKKKREKAYQARS-----QKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYT 1604
Query: 441 THTVYKNLNPEWNKVFTFNIKDIH-SVLEVTVYDEDRDRSADFLGKVAIPLLSIQ-NGEQ 498
T T+ LNP+WN F IKD++ VL +T++D D+ DFLG+ IP+ I+ E
Sbjct: 1605 TRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQES 1664
Query: 499 KAYVLKNKQLTGPTKGVIYLEIDV 522
K + + L G +++ D+
Sbjct: 1665 KGPMTRRLLLHEVPTGEVWVRFDL 1688
Score = 68.6 bits (166), Expect = 2e-11
Identities = 32/97 (32%), Positives = 55/97 (56%)
Query: 249 GIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEER 308
G + + +IE +LKA NG S+PY + +G Q Y ++ + TLNP+W F + +
Sbjct: 1569 GRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLY 1628
Query: 309 GGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHK 345
V+ +T +D+D DDF+GR ++ ++ + EQ K
Sbjct: 1629 QDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESK 1665
Score = 37.7 bits (86), Expect = 0.041
Identities = 24/104 (23%), Positives = 48/104 (46%), Gaps = 2/104 (1%)
Query: 38 GMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVD 97
G+ +L + + L A G S+PY + +G + + ++ I LNP W +
Sbjct: 1567 GIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQS-YTTRTIQDTLNPKWNFNCQFFIK 1625
Query: 98 HL-REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLT 140
L ++ L + +FD D DDF+G + + ++ + + +T
Sbjct: 1626 DLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMT 1669
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 71.6 bits (174), Expect = 3e-12
Identities = 70/253 (27%), Positives = 117/253 (46%), Gaps = 51/253 (20%)
Query: 251 VSITLIEGRDLKAMDSNGLSDPYVKFRL---GHQKYKSKIMPKTLNPQWREQFDFH--LY 305
+++ +++ ++L A D +G SDP+VK L K ++K+ K LNP W E F F Y
Sbjct: 152 LTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPY 211
Query: 306 EE-RGGVIDITAWDKDAGKRDDFIGRCQVDLSA--LSREQTHKLELQ-LEEGEGHLVLLV 361
E+ ++ + D D R+D IG + L+ L++ QT +L+ +G G
Sbjct: 212 EKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSG------ 265
Query: 362 TLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAAD 421
R E+L L + +N + V +I+A L A D
Sbjct: 266 ----------------------SRGELL-----LSLCYN-PSANSIIVNIIKARNLKAMD 297
Query: 422 VTGKSDPFCVVEL-----NNDRLLTHTVYKNLNPEWNKVFTFNI---KDIHSVLEVTVYD 473
+ G SDP+ V L ++ T T+ +NLNP +N+ F F+I K + + +TV D
Sbjct: 298 IGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAFDIPTEKLRETTIIITVMD 357
Query: 474 EDRDRSADFLGKV 486
+D+ D +GK+
Sbjct: 358 KDKLSRNDVIGKI 370
Score = 61.2 bits (147), Expect = 3e-09
Identities = 72/275 (26%), Positives = 117/275 (42%), Gaps = 32/275 (11%)
Query: 370 SISDLSVNSLEDQ-------KEREEILKRYSPLRIFHNLKDVGF------LQVKVIRAEG 416
S+SDL VNSL + E +E + S + VG+ L VK+++A+
Sbjct: 103 SVSDL-VNSLTSEMLMLSPGSEEDEAHEGCSRENLGRIQFSVGYNFQESTLTVKIMKAQE 161
Query: 417 LMAADVTGKSDPFCVVELNND---RLLTHTVYKNLNPEWNKVFTFN----IKDIHSVLEV 469
L A D +G SDPF + L D +L T KNLNP WN+ F F K + +L +
Sbjct: 162 LPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYL 221
Query: 470 TVYDEDRDRSADFLGKVAIPLLSIQNGEQKAY--VLKNKQLTGPTKGVIYLEI------- 520
V D DR D +G+V+IPL + + + + LK ++G + L +
Sbjct: 222 QVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSLCYNPSAN 281
Query: 521 DVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNFIRMKRCVMVLVNAAYYVNSCFDW 580
+I N +KA R L + + + + K+ V + N N F +
Sbjct: 282 SIIVNIIKA--RNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAF 339
Query: 581 DSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTW 615
D P L + + V+ +L ++ + L+W
Sbjct: 340 DIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSW 374
Score = 58.2 bits (139), Expect = 3e-08
Identities = 38/101 (37%), Positives = 53/101 (52%), Gaps = 7/101 (6%)
Query: 251 VSITLIEGRDLKAMDSNGLSDPYVKFRLGH-----QKYKSKIMPKTLNPQWREQFDFHLY 305
+ + +I+ R+LKAMD G SDPYVK L + +K K+ M + LNP + E F F +
Sbjct: 283 IIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAFDIP 342
Query: 306 EE--RGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTH 344
E R I IT DKD R+D IG+ + + E H
Sbjct: 343 TEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKH 383
Score = 55.5 bits (132), Expect = 2e-07
Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 6/127 (4%)
Query: 42 LDITLRRGQSLAARDRGGTSDPYVKFKI--GGKEVFRSKIIHKNLNPVWEE----KACIL 95
L + + + Q L A+D GTSDP+VK + K +K+ KNLNP W E +
Sbjct: 152 LTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPY 211
Query: 96 VDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHDLGIIL 155
++ LY++V DYD ++D +G + L +++L + LK G +L
Sbjct: 212 EKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELL 271
Query: 156 LSVILTP 162
LS+ P
Sbjct: 272 LSLCYNP 278
Score = 44.7 bits (104), Expect = 3e-04
Identities = 31/96 (32%), Positives = 51/96 (53%), Gaps = 7/96 (7%)
Query: 36 DPGMYQLDITLRRGQSLAARDRGGTSDPYVK----FKIGGKEVFRSKIIHKNLNPVWEEK 91
+P + + + + ++L A D GGTSDPYVK +K E ++ + +NLNP++ E
Sbjct: 277 NPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNES 336
Query: 92 AC--ILVDHLRE-PLYIKVFDYDFGLQDDFMGSAFL 124
I + LRE + I V D D ++D +G +L
Sbjct: 337 FAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYL 372
>gi|103472031 family with sequence similarity 62 (C2 domain
containing), member C [Homo sapiens]
Length = 886
Score = 71.2 bits (173), Expect = 3e-12
Identities = 64/262 (24%), Positives = 116/262 (44%), Gaps = 34/262 (12%)
Query: 249 GIVSITLIEGRDLKAMDS----NGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHL 304
G++ + L+E L D+ G SDPY K +G Q ++S+ + + LNP W E F+F +
Sbjct: 306 GVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMV 365
Query: 305 YEERGGVIDITAWDKDAGKRDDFIGRCQVDLS------------ALSREQTHKLELQLEE 352
YE G +++ +D+D RDDF+G Q+ L L+ + +L L+LE
Sbjct: 366 YEVPGQDLEVDLYDEDT-DRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHLRLE- 423
Query: 353 GEGHLVLLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVI 412
+ L+T T LS L ++ S + N D + +
Sbjct: 424 ----WLSLLTDQEVLTEDHGGLSTAIL--------VVFLESACNLPRNPFDYLNGEYRAK 471
Query: 413 RAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSV-LEVTV 471
+ V+ + + + + T N +P W++VF+F + ++ + L + V
Sbjct: 472 KLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKV 531
Query: 472 YDEDRDRSADFLGKVAIPLLSI 493
D+D++ + LG + +PL I
Sbjct: 532 LDDDQECA---LGMLEVPLCQI 550
Score = 68.9 bits (167), Expect = 2e-11
Identities = 48/157 (30%), Positives = 80/157 (50%), Gaps = 22/157 (14%)
Query: 405 GFLQVKVIRAEGLMAAD----VTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNI 460
G ++V ++ AE L D + GKSDP+ V + + T+Y+NLNP WN+VF F +
Sbjct: 306 GVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMV 365
Query: 461 KDIHSV-LEVTVYDEDRDRSADFLGKVAIPLLSIQNGE--QKAYVLKNKQLTGPTKGVIY 517
++ LEV +YDED DR DFLG + I L + + +VL + T G ++
Sbjct: 366 YEVPGQDLEVDLYDEDTDRD-DFLGSLQICLGDVMTNRVVDEWFVLND-----TTSGRLH 419
Query: 518 LEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLL 554
L ++ + +L+ ++ E+ LS +L+
Sbjct: 420 LRLEWL---------SLLTDQEVLTEDHGGLSTAILV 447
Score = 53.5 bits (127), Expect = 7e-07
Identities = 37/105 (35%), Positives = 54/105 (51%), Gaps = 7/105 (6%)
Query: 44 ITLRRGQSLAARDR----GGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHL 99
+ L + LA +D G SDPY K IG + FRS+ I++NLNP W E +V +
Sbjct: 310 VHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQH-FRSRTIYRNLNPTWNEVFEFMVYEV 368
Query: 100 -REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKD 143
+ L + ++D D +DDF+GS + L + NR D L D
Sbjct: 369 PGQDLEVDLYDEDTD-RDDFLGSLQICLGDVMTNRVVDEWFVLND 412
Score = 31.2 bits (69), Expect = 3.8
Identities = 35/124 (28%), Positives = 53/124 (42%), Gaps = 24/124 (19%)
Query: 7 LKSACNLPFICNKKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVK 66
L+SACNLP N N E Y+ R ++ ++D YVK
Sbjct: 450 LESACNLPR-------NPFDYLNGE--------YRAKKLSRFARNKVSKDPSS----YVK 490
Query: 67 FKIGGKEVFRSKIIHKNLNPVWEEKACILVDHL-REPLYIKVFDYDFGLQDDFMGSAFLD 125
+G K+ SK N +PVW + V ++ E L++KV D D Q+ +G +
Sbjct: 491 LSVG-KKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDD---QECALGMLEVP 546
Query: 126 LTQL 129
L Q+
Sbjct: 547 LCQI 550
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,018,158
Number of Sequences: 37866
Number of extensions: 1278917
Number of successful extensions: 8355
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 7017
Number of HSP's gapped (non-prelim): 954
length of query: 778
length of database: 18,247,518
effective HSP length: 110
effective length of query: 668
effective length of database: 14,082,258
effective search space: 9406948344
effective search space used: 9406948344
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.