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Search of human proteins with 50355990
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50355990 MORN repeat containing 3 [Homo sapiens]
(240 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50355990 MORN repeat containing 3 [Homo sapiens] 533 e-152
gi|153792461 radial spoke head 10 homolog B2 [Homo sapiens] 100 1e-21
gi|157502187 radial spoke head 10 homolog B [Homo sapiens] 100 1e-21
gi|13376267 MORN repeat containing 1 [Homo sapiens] 93 2e-19
gi|18254456 testis-specific gene A2 [Homo sapiens] 89 4e-18
gi|21704283 junctophilin 3 [Homo sapiens] 77 2e-14
gi|40316935 alsin isoform 1 [Homo sapiens] 74 9e-14
gi|21704281 junctophilin 2 isoform 1 [Homo sapiens] 74 1e-13
gi|21735575 junctophilin 1 [Homo sapiens] 72 4e-13
gi|33359215 ALS2 C-terminal like isoform 1 [Homo sapiens] 67 1e-11
gi|225690502 junctophilin 4 [Homo sapiens] 63 3e-10
gi|225690500 junctophilin 4 [Homo sapiens] 63 3e-10
gi|149999376 MORN repeat containing 4 [Homo sapiens] 62 6e-10
gi|30520314 MORN repeat containing 4 [Homo sapiens] 62 6e-10
gi|29893812 junctophilin 2 isoform 2 [Homo sapiens] 60 1e-09
gi|18139549 SET domain-containing protein 7 [Homo sapiens] 47 1e-05
gi|75750529 ankyrin repeat and MYND domain containing 1 isoform ... 42 4e-04
gi|75750531 ankyrin repeat and MYND domain containing 1 isoform ... 39 0.003
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 39 0.004
gi|224282170 MORN repeat containing 2 [Homo sapiens] 39 0.005
gi|223278407 MORN repeat containing 5 [Homo sapiens] 36 0.026
gi|110556636 tankyrase 1-binding protein 1 [Homo sapiens] 35 0.076
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 34 0.099
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 28 5.4
gi|28559065 DNA cytosine-5 methyltransferase 3 beta isoform 6 [H... 28 5.4
gi|28559063 DNA cytosine-5 methyltransferase 3 beta isoform 3 [H... 28 5.4
gi|28559061 DNA cytosine-5 methyltransferase 3 beta isoform 2 [H... 28 5.4
gi|5901940 DNA cytosine-5 methyltransferase 3 beta isoform 1 [Ho... 28 5.4
gi|148806908 fibronectin type III domain containing 1 [Homo sapi... 28 5.4
gi|208022678 hypothetical protein LOC374877 [Homo sapiens] 28 5.4
>gi|50355990 MORN repeat containing 3 [Homo sapiens]
Length = 240
Score = 533 bits (1374), Expect = e-152
Identities = 240/240 (100%), Positives = 240/240 (100%)
Query: 1 MPVSKCPKKSESLWKGWDRKAQRNGLRSQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGA 60
MPVSKCPKKSESLWKGWDRKAQRNGLRSQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGA
Sbjct: 1 MPVSKCPKKSESLWKGWDRKAQRNGLRSQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGA 60
Query: 61 IYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCG 120
IYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCG
Sbjct: 61 IYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCG 120
Query: 121 SQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDH 180
SQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDH
Sbjct: 121 SQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDH 180
Query: 181 GQLFEGFWVDNMAKCGTMIDFGRDEAPEPTQFPIPEVKILDPDGVLAEALAMFRKTEEGD 240
GQLFEGFWVDNMAKCGTMIDFGRDEAPEPTQFPIPEVKILDPDGVLAEALAMFRKTEEGD
Sbjct: 181 GQLFEGFWVDNMAKCGTMIDFGRDEAPEPTQFPIPEVKILDPDGVLAEALAMFRKTEEGD 240
>gi|153792461 radial spoke head 10 homolog B2 [Homo sapiens]
Length = 870
Score = 100 bits (248), Expect = 1e-21
Identities = 56/163 (34%), Positives = 86/163 (52%), Gaps = 10/163 (6%)
Query: 14 WKGWDRKAQRNGLRSQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDG 73
++G + +G + ++A +G Y G++ NV G W G++YEG+ G R+G
Sbjct: 109 YRGMFSEGLMHGQGTYIWA-DGLKYEGDFVKNVPMNHGVYTWPD-GSMYEGEVVNGMRNG 166
Query: 74 YGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKE--YYEGDWCGSQRSGWGRMYY 131
+G Q Y G W K+ G G ++ + +YEGDW + + GWG Y
Sbjct: 167 FGMFKCSTQPVS-----YIGHWCNGKRHGKGSIYYNQEGTCWYEGDWVQNIKKGWGIRCY 221
Query: 132 SNGDIYEGQWENDKPNGEGMLR-LKNGNRYEGCWERGMKNGAG 173
+G+IYEGQWE++ +GEG +R L Y G WERG++NG G
Sbjct: 222 KSGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGIQNGFG 264
Score = 86.3 bits (212), Expect = 2e-17
Identities = 45/154 (29%), Positives = 78/154 (50%), Gaps = 29/154 (18%)
Query: 11 ESLWKGWDRKAQRNGLRSQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGK 70
+++ KGW + ++G + Y G+WEDN++HG+G W Y G W+ G
Sbjct: 210 QNIKKGWGIRCYKSG----------NIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGI 259
Query: 71 RDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMY 130
++G+GT ++ + K + S Y + + Y G++ R G G+ Y
Sbjct: 260 QNGFGT--------------HTWFLKRIRSSQYPL-----RNEYIGEFVNGYRHGRGKFY 300
Query: 131 YSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCW 164
Y++G +Y+G+W ++K +G G L KNG YEG +
Sbjct: 301 YASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAF 334
Score = 82.0 bits (201), Expect = 4e-16
Identities = 50/157 (31%), Positives = 74/157 (47%), Gaps = 10/157 (6%)
Query: 35 GDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGW 94
G Y G + + + HG+GT +W G YEGD+ +G + PD +Y G
Sbjct: 106 GCTYRGMFSEGLMHGQGTYIWAD-GLKYEGDFVKNVPMNHGVYTWPDGS------MYEGE 158
Query: 95 WKGDKKSGYGIQFFGPKEY-YEGDWCGSQRSGWGRMYYSNGDI--YEGQWENDKPNGEGM 151
++G+G+ + Y G WC +R G G +YY+ YEG W + G G+
Sbjct: 159 VVNGMRNGFGMFKCSTQPVSYIGHWCNGKRHGKGSIYYNQEGTCWYEGDWVQNIKKGWGI 218
Query: 152 LRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFW 188
K+GN YEG WE M++G GR L + + G W
Sbjct: 219 RCYKSGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRW 255
Score = 71.6 bits (174), Expect = 6e-13
Identities = 49/187 (26%), Positives = 84/187 (44%), Gaps = 19/187 (10%)
Query: 12 SLWKGWDRKAQRNGLRSQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGAI-YEGDWKFGK 70
S+++G RNG + Y+G W + +HGKG+ + ++G YEGDW
Sbjct: 153 SMYEGEVVNGMRNGFGMFKCSTQPVSYIGHWCNGKRHGKGSIYYNQEGTCWYEGDWVQNI 212
Query: 71 RDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYG-IQFFGPKEYYEGDWCGSQRSGWGR- 128
+ G+G + K +Y G W+ + + G G +++ E Y G W ++G+G
Sbjct: 213 KKGWGI------RCYKSGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGIQNGFGTH 266
Query: 129 ---------MYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLD 179
Y + Y G++ N +G G +G Y+G W K+G GR
Sbjct: 267 TWFLKRIRSSQYPLRNEYIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGMGR-LTFK 325
Query: 180 HGQLFEG 186
+G+++EG
Sbjct: 326 NGRVYEG 332
Score = 38.9 bits (89), Expect = 0.004
Identities = 25/87 (28%), Positives = 36/87 (41%)
Query: 102 GYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYE 161
G G F Y G + G G +++G YEG + + P G+ +G+ YE
Sbjct: 97 GEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMNHGVYTWPDGSMYE 156
Query: 162 GCWERGMKNGAGRFFHLDHGQLFEGFW 188
G GM+NG G F + G W
Sbjct: 157 GEVVNGMRNGFGMFKCSTQPVSYIGHW 183
Score = 33.9 bits (76), Expect = 0.13
Identities = 18/56 (32%), Positives = 27/56 (48%), Gaps = 1/56 (1%)
Query: 137 YEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFWVDNM 192
YEG+ GEG + G Y G + G+ +G G + D G +EG +V N+
Sbjct: 86 YEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWAD-GLKYEGDFVKNV 140
Score = 33.5 bits (75), Expect = 0.17
Identities = 25/92 (27%), Positives = 39/92 (42%), Gaps = 7/92 (7%)
Query: 112 EYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNG 171
E YEG+ G G + G Y G + +G+G +G +YEG + + +
Sbjct: 84 ESYEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMN 143
Query: 172 AGRFFHLDHGQLFEGFWVDNMA------KCGT 197
G + D G ++EG V+ M KC T
Sbjct: 144 HGVYTWPD-GSMYEGEVVNGMRNGFGMFKCST 174
>gi|157502187 radial spoke head 10 homolog B [Homo sapiens]
Length = 870
Score = 100 bits (248), Expect = 1e-21
Identities = 56/163 (34%), Positives = 86/163 (52%), Gaps = 10/163 (6%)
Query: 14 WKGWDRKAQRNGLRSQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDG 73
++G + +G + ++A +G Y G++ NV G W G++YEG+ G R+G
Sbjct: 109 YRGMFSEGLMHGQGTYIWA-DGLKYEGDFVKNVPMNHGVYTWPD-GSMYEGEVVNGMRNG 166
Query: 74 YGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKE--YYEGDWCGSQRSGWGRMYY 131
+G Q Y G W K+ G G ++ + +YEGDW + + GWG Y
Sbjct: 167 FGMFKCSTQPVS-----YIGHWCNGKRHGKGSIYYNQEGTCWYEGDWVQNIKKGWGIRCY 221
Query: 132 SNGDIYEGQWENDKPNGEGMLR-LKNGNRYEGCWERGMKNGAG 173
+G+IYEGQWE++ +GEG +R L Y G WERG++NG G
Sbjct: 222 KSGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGIQNGFG 264
Score = 86.3 bits (212), Expect = 2e-17
Identities = 45/154 (29%), Positives = 78/154 (50%), Gaps = 29/154 (18%)
Query: 11 ESLWKGWDRKAQRNGLRSQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGK 70
+++ KGW + ++G + Y G+WEDN++HG+G W Y G W+ G
Sbjct: 210 QNIKKGWGIRCYKSG----------NIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGI 259
Query: 71 RDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMY 130
++G+GT ++ + K + S Y + + Y G++ R G G+ Y
Sbjct: 260 QNGFGT--------------HTWFLKRIRSSQYPL-----RNEYIGEFVNGYRHGRGKFY 300
Query: 131 YSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCW 164
Y++G +Y+G+W ++K +G G L KNG YEG +
Sbjct: 301 YASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAF 334
Score = 82.0 bits (201), Expect = 4e-16
Identities = 50/157 (31%), Positives = 74/157 (47%), Gaps = 10/157 (6%)
Query: 35 GDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGW 94
G Y G + + + HG+GT +W G YEGD+ +G + PD +Y G
Sbjct: 106 GCTYRGMFSEGLMHGQGTYIWAD-GLKYEGDFVKNVPMNHGVYTWPDGS------MYEGE 158
Query: 95 WKGDKKSGYGIQFFGPKEY-YEGDWCGSQRSGWGRMYYSNGDI--YEGQWENDKPNGEGM 151
++G+G+ + Y G WC +R G G +YY+ YEG W + G G+
Sbjct: 159 VVNGMRNGFGMFKCSTQPVSYIGHWCNGKRHGKGSIYYNQEGTCWYEGDWVQNIKKGWGI 218
Query: 152 LRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFW 188
K+GN YEG WE M++G GR L + + G W
Sbjct: 219 RCYKSGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRW 255
Score = 71.6 bits (174), Expect = 6e-13
Identities = 49/187 (26%), Positives = 84/187 (44%), Gaps = 19/187 (10%)
Query: 12 SLWKGWDRKAQRNGLRSQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGAI-YEGDWKFGK 70
S+++G RNG + Y+G W + +HGKG+ + ++G YEGDW
Sbjct: 153 SMYEGEVVNGMRNGFGMFKCSTQPVSYIGHWCNGKRHGKGSIYYNQEGTCWYEGDWVQNI 212
Query: 71 RDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYG-IQFFGPKEYYEGDWCGSQRSGWGR- 128
+ G+G + K +Y G W+ + + G G +++ E Y G W ++G+G
Sbjct: 213 KKGWGI------RCYKSGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGIQNGFGTH 266
Query: 129 ---------MYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLD 179
Y + Y G++ N +G G +G Y+G W K+G GR
Sbjct: 267 TWFLKRIRSSQYPLRNEYIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGMGR-LTFK 325
Query: 180 HGQLFEG 186
+G+++EG
Sbjct: 326 NGRVYEG 332
Score = 38.9 bits (89), Expect = 0.004
Identities = 25/87 (28%), Positives = 36/87 (41%)
Query: 102 GYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYE 161
G G F Y G + G G +++G YEG + + P G+ +G+ YE
Sbjct: 97 GEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMNHGVYTWPDGSMYE 156
Query: 162 GCWERGMKNGAGRFFHLDHGQLFEGFW 188
G GM+NG G F + G W
Sbjct: 157 GEVVNGMRNGFGMFKCSTQPVSYIGHW 183
Score = 33.9 bits (76), Expect = 0.13
Identities = 18/56 (32%), Positives = 27/56 (48%), Gaps = 1/56 (1%)
Query: 137 YEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFWVDNM 192
YEG+ GEG + G Y G + G+ +G G + D G +EG +V N+
Sbjct: 86 YEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWAD-GLKYEGDFVKNV 140
Score = 33.5 bits (75), Expect = 0.17
Identities = 25/92 (27%), Positives = 39/92 (42%), Gaps = 7/92 (7%)
Query: 112 EYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNG 171
E YEG+ G G + G Y G + +G+G +G +YEG + + +
Sbjct: 84 ESYEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMN 143
Query: 172 AGRFFHLDHGQLFEGFWVDNMA------KCGT 197
G + D G ++EG V+ M KC T
Sbjct: 144 HGVYTWPD-GSMYEGEVVNGMRNGFGMFKCST 174
>gi|13376267 MORN repeat containing 1 [Homo sapiens]
Length = 497
Score = 92.8 bits (229), Expect = 2e-19
Identities = 61/214 (28%), Positives = 101/214 (47%), Gaps = 12/214 (5%)
Query: 20 KAQRNGLRSQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSL 79
KA R ++ +G YY G + D G+G + W G + G + G+ GYG +
Sbjct: 44 KAGRKHGHGKLLFKDGSYYEGAFVDGEITGEGRRHWAWSGDTFSGQFVLGEPQGYGVM-- 101
Query: 80 PDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEG 139
+ + G C Y G + G+G + Y+G + ++R G G+M + NGD Y+G
Sbjct: 102 -EYKAGGC---YEGEVSHGMREGHGFLVDRDGQVYQGSFHDNKRHGPGQMLFQNGDKYDG 157
Query: 140 QWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFWVD-NMAKCGTM 198
W D+ G G+LR +G+ Y+G W + +G G H G + G W++ + A+ T
Sbjct: 158 DWVRDRRQGHGVLRCADGSTYKGQWHSDVFSGLGSMAHCS-GVTYYGLWINGHPAEQATR 216
Query: 199 IDFGRDEAPEPTQ---FPIPEVKILDPDGVLAEA 229
I E E Q F + V++L G +A++
Sbjct: 217 IVILGPEVMEVAQGSPFSV-NVQLLQDHGEIAKS 249
Score = 71.6 bits (174), Expect = 6e-13
Identities = 42/122 (34%), Positives = 63/122 (51%), Gaps = 7/122 (5%)
Query: 71 RDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMY 130
R+GYG P+ Y G WK +K G+G F YYEG + + +G GR +
Sbjct: 24 RNGYGVYVYPNSFFR-----YEGEWKAGRKHGHGKLLFKDGSYYEGAFVDGEITGEGRRH 78
Query: 131 YS-NGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFWV 189
++ +GD + GQ+ +P G G++ K G YEG GM+ G G D GQ+++G +
Sbjct: 79 WAWSGDTFSGQFVLGEPQGYGVMEYKAGGCYEGEVSHGMREGHGFLVDRD-GQVYQGSFH 137
Query: 190 DN 191
DN
Sbjct: 138 DN 139
>gi|18254456 testis-specific gene A2 [Homo sapiens]
Length = 309
Score = 88.6 bits (218), Expect = 4e-18
Identities = 49/147 (33%), Positives = 69/147 (46%), Gaps = 8/147 (5%)
Query: 35 GDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGW 94
G+Y G E +HG+G + G YEG ++FGKR G G + Y G
Sbjct: 18 GEYEGGRNEAGERHGRG-RARLPNGDTYEGSYEFGKRHGQGIYKFKNGAR------YIGE 70
Query: 95 WKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGM-LR 153
+ +KK G G + YEG+W R G G YY N D Y G+W + +G+G L
Sbjct: 71 YVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLY 130
Query: 154 LKNGNRYEGCWERGMKNGAGRFFHLDH 180
+ G++Y G W G + G HL+H
Sbjct: 131 AETGSKYVGTWVNGQQEGTAELIHLNH 157
Score = 80.1 bits (196), Expect = 2e-15
Identities = 50/161 (31%), Positives = 76/161 (47%), Gaps = 10/161 (6%)
Query: 16 GWDRKAQRNGLRSQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYG 75
G + +R+G R + NGD Y G +E +HG+G + K GA Y G++ K+ G G
Sbjct: 23 GRNEAGERHG-RGRARLPNGDTYEGSYEFGKRHGQGIYKF-KNGARYIGEYVRNKKHGQG 80
Query: 76 TLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGR-MYYSNG 134
T PD Y G W D + G+G+ ++ + Y G+W QR G G +Y G
Sbjct: 81 TFIYPDGSR------YEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAETG 134
Query: 135 DIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRF 175
Y G W N + G L + +RY+G + G G++
Sbjct: 135 SKYVGTWVNGQQEGTAEL-IHLNHRYQGKFLNKNPVGPGKY 174
Score = 73.2 bits (178), Expect = 2e-13
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 7/130 (5%)
Query: 62 YEGDW-KFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCG 120
YEG + G+R G G LP+ T Y G ++ K+ G GI F Y G++
Sbjct: 20 YEGGRNEAGERHGRGRARLPNGDT------YEGSYEFGKRHGQGIYKFKNGARYIGEYVR 73
Query: 121 SQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDH 180
+++ G G Y +G YEG+W ND +G G+ N + Y G W ++G G + + +
Sbjct: 74 NKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAET 133
Query: 181 GQLFEGFWVD 190
G + G WV+
Sbjct: 134 GSKYVGTWVN 143
Score = 63.2 bits (152), Expect = 2e-10
Identities = 33/81 (40%), Positives = 46/81 (56%), Gaps = 1/81 (1%)
Query: 112 EYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNG 171
EY G +R G GR NGD YEG +E K +G+G+ + KNG RY G + R K+G
Sbjct: 19 EYEGGRNEAGERHGRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKHG 78
Query: 172 AGRFFHLDHGQLFEGFWVDNM 192
G F + D G +EG W +++
Sbjct: 79 QGTFIYPD-GSRYEGEWANDL 98
Score = 37.0 bits (84), Expect = 0.015
Identities = 20/58 (34%), Positives = 32/58 (55%), Gaps = 1/58 (1%)
Query: 134 GDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFWVDN 191
G+ G+ E + +G G RL NG+ YEG +E G ++G G + +G + G +V N
Sbjct: 18 GEYEGGRNEAGERHGRGRARLPNGDTYEGSYEFGKRHGQG-IYKFKNGARYIGEYVRN 74
>gi|21704283 junctophilin 3 [Homo sapiens]
Length = 748
Score = 76.6 bits (187), Expect = 2e-14
Identities = 47/141 (33%), Positives = 61/141 (43%), Gaps = 9/141 (6%)
Query: 34 NGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSG 93
+G Y G WED HG G K Y G W G + G + P T Y G
Sbjct: 11 DGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGF-EVLGVYTWPSGNT------YQG 63
Query: 94 WWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWG-RMYYSNGDIYEGQWENDKPNGEGML 152
W K+ G G++ G K Y+G+W + +G R NG YEG W N +G G
Sbjct: 64 TWAQGKRHGIGLESKG-KWVYKGEWTHGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTE 122
Query: 153 RLKNGNRYEGCWERGMKNGAG 173
+G Y+G W GM+ G G
Sbjct: 123 TYSDGGTYQGQWVGGMRQGYG 143
Score = 52.8 bits (125), Expect = 3e-07
Identities = 27/69 (39%), Positives = 33/69 (47%), Gaps = 6/69 (8%)
Query: 38 YVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKG 97
Y GEW K G + GA YEG W G +DGYGT + D T Y G W G
Sbjct: 83 YKGEWTHGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTETYSDGGT------YQGQWVG 136
Query: 98 DKKSGYGIQ 106
+ GYG++
Sbjct: 137 GMRQGYGVR 145
Score = 48.9 bits (115), Expect = 4e-06
Identities = 20/54 (37%), Positives = 33/54 (61%)
Query: 91 YSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWEND 144
Y G WK DK+SG+G+ YEG+W ++R G+G M + +G EG+++ +
Sbjct: 288 YVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDGTKEEGKYKQN 341
Score = 47.0 bits (110), Expect = 1e-05
Identities = 21/63 (33%), Positives = 37/63 (58%)
Query: 112 EYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNG 171
E Y G+W +RSG+G S+G YEG+W +++ +G G + +G + EG +++ + G
Sbjct: 286 ETYVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDGTKEEGKYKQNILVG 345
Query: 172 AGR 174
R
Sbjct: 346 GKR 348
Score = 45.8 bits (107), Expect = 3e-05
Identities = 22/74 (29%), Positives = 41/74 (55%), Gaps = 3/74 (4%)
Query: 18 DRKAQRNGLRSQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTL 77
+ +A+ + + A + YVGEW+++ + G G + G YEG+W +R GYG +
Sbjct: 268 EAEAELAVIEDDIDATTTETYVGEWKNDKRSGFGVSQ-RSDGLKYEGEWASNRRHGYGCM 326
Query: 78 SLPD--QQTGKCRR 89
+ PD ++ GK ++
Sbjct: 327 TFPDGTKEEGKYKQ 340
Score = 40.4 bits (93), Expect = 0.001
Identities = 18/44 (40%), Positives = 24/44 (54%), Gaps = 1/44 (2%)
Query: 32 AVNGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYG 75
A NG Y G W + ++ G GT+ + G Y+G W G R GYG
Sbjct: 101 AGNGAKYEGTWSNGLQDGYGTETY-SDGGTYQGQWVGGMRQGYG 143
Score = 34.3 bits (77), Expect = 0.099
Identities = 19/66 (28%), Positives = 28/66 (42%), Gaps = 3/66 (4%)
Query: 124 SGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNG-NRYEGCWERGMKNGAGRFFHLDHGQ 182
S GR + +G Y G WE+ K +G G+ G Y G W G + + G
Sbjct: 2 SSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFE--VLGVYTWPSGN 59
Query: 183 LFEGFW 188
++G W
Sbjct: 60 TYQGTW 65
>gi|40316935 alsin isoform 1 [Homo sapiens]
Length = 1657
Score = 74.3 bits (181), Expect = 9e-14
Identities = 50/169 (29%), Positives = 77/169 (45%), Gaps = 10/169 (5%)
Query: 38 YVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKG 97
Y G W HG+G W G +Y G ++ G DGYG +P++ K Y G WK
Sbjct: 1049 YDGRWLSGKPHGRGVLKWPD-GKMYSGMFRNGLEDGYGEYRIPNKAMNK-EDHYVGHWKE 1106
Query: 98 DKKSGYGIQFFGPKEYYEGDWCGSQRSGW-----GRMYYSNGDIYEGQWENDKPNGEGML 152
K G G+ + E +EG + + R G G++ S+ ++ GQW DK G G+
Sbjct: 1107 GKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVF 1166
Query: 153 -RLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEG-FWVDNMAKCGTMI 199
+ G +Y G W+ + G G G +EG F ++ M G ++
Sbjct: 1167 DDITRGEKYMGMWQDDVCQGNG-VVVTQFGLYYEGNFHLNKMMGNGVLL 1214
Score = 71.6 bits (174), Expect = 6e-13
Identities = 41/147 (27%), Positives = 72/147 (48%), Gaps = 16/147 (10%)
Query: 58 KGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYG-----IQFFGPKE 112
K A Y+G W GK G G L PD ++YSG ++ + GYG + ++
Sbjct: 1045 KDATYDGRWLSGKPHGRGVLKWPD------GKMYSGMFRNGLEDGYGEYRIPNKAMNKED 1098
Query: 113 YYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLR-----LKNGNRYEGCWERG 167
+Y G W + G G Y++G+++EG ++++ +G G+LR + + + G W
Sbjct: 1099 HYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMD 1158
Query: 168 MKNGAGRFFHLDHGQLFEGFWVDNMAK 194
K G G F + G+ + G W D++ +
Sbjct: 1159 KKAGYGVFDDITRGEKYMGMWQDDVCQ 1185
Score = 62.0 bits (149), Expect = 4e-10
Identities = 43/154 (27%), Positives = 69/154 (44%), Gaps = 3/154 (1%)
Query: 36 DYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWW 95
D+YVG W++ G+G + G ++EG ++ R G+G L + T ++ G W
Sbjct: 1098 DHYVGHWKEGKMCGQGVYSYAS-GEVFEGCFQDNMRHGHGLLR-SGKLTSSSPSMFIGQW 1155
Query: 96 KGDKKSGYGI-QFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRL 154
DKK+GYG+ E Y G W G G + G YEG + +K G G+L
Sbjct: 1156 VMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLS 1215
Query: 155 KNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFW 188
++ YEG + + +G EG++
Sbjct: 1216 EDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYF 1249
Score = 62.0 bits (149), Expect = 4e-10
Identities = 42/145 (28%), Positives = 72/145 (49%), Gaps = 14/145 (9%)
Query: 34 NGDYYVGEWEDNVKHGKGT----QVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRR 89
+G+ + G ++DN++HG G ++ +++ G W K+ GYG D G+
Sbjct: 1119 SGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFD--DITRGE--- 1173
Query: 90 VYSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWEND-KPNG 148
Y G W+ D G G+ YYEG++ ++ G G + + IYEG++ +D +G
Sbjct: 1174 KYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSG 1233
Query: 149 EGMLRLKNGNRYEGC----WERGMK 169
+G L + NG+ EG W G+K
Sbjct: 1234 KGTLTMPNGDYIEGYFSGEWGSGIK 1258
Score = 44.3 bits (103), Expect = 1e-04
Identities = 24/103 (23%), Positives = 45/103 (43%), Gaps = 27/103 (26%)
Query: 137 YEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRF--------------------- 175
Y+G+W + KP+G G+L+ +G Y G + G+++G G +
Sbjct: 1049 YDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGK 1108
Query: 176 ------FHLDHGQLFEGFWVDNMAKCGTMIDFGRDEAPEPTQF 212
+ G++FEG + DNM ++ G+ + P+ F
Sbjct: 1109 MCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMF 1151
Score = 42.0 bits (97), Expect = 5e-04
Identities = 36/124 (29%), Positives = 53/124 (42%), Gaps = 13/124 (10%)
Query: 35 GDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGW 94
G+ Y+G W+D+V G G V + G YEG++ K G G L D +Y G
Sbjct: 1172 GEKYMGMWQDDVCQGNGVVV-TQFGLYYEGNFHLNKMMGNGVLLSEDD------TIYEGE 1224
Query: 95 WKGD-KKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYE-GQWENDKPNGEGML 152
+ D SG G +Y EG + G WG G ++ +E+DK +
Sbjct: 1225 FSDDWTLSGKGTLTMPNGDYIEGYFSGE----WGSGIKITGTYFKPSLYESDKDRPKVFR 1280
Query: 153 RLKN 156
+L N
Sbjct: 1281 KLGN 1284
>gi|21704281 junctophilin 2 isoform 1 [Homo sapiens]
Length = 696
Score = 73.9 bits (180), Expect = 1e-13
Identities = 45/141 (31%), Positives = 63/141 (44%), Gaps = 9/141 (6%)
Query: 34 NGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSG 93
+G Y G WE HG G K Y G W FG G + P T + G
Sbjct: 10 DGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVA-GVYTWPSGNT------FEG 62
Query: 94 WWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWG-RMYYSNGDIYEGQWENDKPNGEGML 152
+W K+ G GI+ G + Y+G+W + +G R S+G YEG W N +G G
Sbjct: 63 YWSQGKRHGLGIETKG-RWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTE 121
Query: 153 RLKNGNRYEGCWERGMKNGAG 173
+G Y+G + GM++G G
Sbjct: 122 TYADGGTYQGQFTNGMRHGYG 142
Score = 48.1 bits (113), Expect = 7e-06
Identities = 31/98 (31%), Positives = 47/98 (47%), Gaps = 10/98 (10%)
Query: 10 SESLWKGWDRKAQRNGLRSQVYAVNGDY-YVGEWEDNVKHGKGTQVWKKKGAIYEGDWKF 68
S + ++G+ + +R+GL + G + Y GEW K G + GA YEG W
Sbjct: 56 SGNTFEGYWSQGKRHGLGIET---KGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNN 112
Query: 69 GKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQ 106
G +DGYGT + D T Y G + + GYG++
Sbjct: 113 GLQDGYGTETYADGGT------YQGQFTNGMRHGYGVR 144
Score = 45.8 bits (107), Expect = 3e-05
Identities = 24/69 (34%), Positives = 37/69 (53%), Gaps = 3/69 (4%)
Query: 91 YSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWEND---KPN 147
Y G WK DK+SG+G+ YEG+W + R G+G +G EG++ ++ K
Sbjct: 291 YMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDGHREEGKYRHNVLVKDT 350
Query: 148 GEGMLRLKN 156
ML+LK+
Sbjct: 351 KRRMLQLKS 359
Score = 43.9 bits (102), Expect = 1e-04
Identities = 21/51 (41%), Positives = 31/51 (60%)
Query: 112 EYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEG 162
E Y G+W +RSG+G S+G YEG+W ++ +G G L +G+R EG
Sbjct: 289 ETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDGHREEG 339
Score = 43.1 bits (100), Expect = 2e-04
Identities = 22/63 (34%), Positives = 35/63 (55%), Gaps = 3/63 (4%)
Query: 28 SQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPD--QQTG 85
+ + A + Y+GEW+++ + G G + G YEG+W R GYG +LPD ++ G
Sbjct: 281 ADIDATTTETYMGEWKNDKRSGFGVSE-RSSGLRYEGEWLDNLRHGYGCTTLPDGHREEG 339
Query: 86 KCR 88
K R
Sbjct: 340 KYR 342
Score = 40.0 bits (92), Expect = 0.002
Identities = 16/39 (41%), Positives = 25/39 (64%)
Query: 135 DIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAG 173
+ Y G+W+NDK +G G+ +G RYEG W +++G G
Sbjct: 289 ETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYG 327
Score = 38.5 bits (88), Expect = 0.005
Identities = 20/63 (31%), Positives = 27/63 (42%), Gaps = 3/63 (4%)
Query: 127 GRMYYSNGDIYEGQWENDKPNGEGMLRLKNG-NRYEGCWERGMKNGAGRFFHLDHGQLFE 185
GR + +G Y G WE K +G G+ G Y G W G + + G FE
Sbjct: 4 GRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFE--VAGVYTWPSGNTFE 61
Query: 186 GFW 188
G+W
Sbjct: 62 GYW 64
>gi|21735575 junctophilin 1 [Homo sapiens]
Length = 661
Score = 72.0 bits (175), Expect = 4e-13
Identities = 44/141 (31%), Positives = 61/141 (43%), Gaps = 9/141 (6%)
Query: 34 NGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSG 93
+G Y G WE+ HG G K Y G W G + G + P T Y G
Sbjct: 10 DGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGF-EVVGGYTWPSGNT------YQG 62
Query: 94 WWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWG-RMYYSNGDIYEGQWENDKPNGEGML 152
+W K+ G G++ G K Y G+W + +G R YEG W N +G G+
Sbjct: 63 YWAQGKRHGLGVETKG-KWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVE 121
Query: 153 RLKNGNRYEGCWERGMKNGAG 173
+G Y+G W GM++G G
Sbjct: 122 TYGDGGTYQGQWAGGMRHGYG 142
Score = 48.9 bits (115), Expect = 4e-06
Identities = 19/54 (35%), Positives = 33/54 (61%)
Query: 91 YSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWEND 144
Y G WK DK++G+G+ YEG+W ++R G+G + +G EG+++N+
Sbjct: 281 YMGEWKNDKRNGFGVSERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNN 334
Score = 47.8 bits (112), Expect = 9e-06
Identities = 31/98 (31%), Positives = 46/98 (46%), Gaps = 10/98 (10%)
Query: 10 SESLWKGWDRKAQRNGLRSQVYAVNGDY-YVGEWEDNVKHGKGTQVWKKKGAIYEGDWKF 68
S + ++G+ + +R+GL + G + Y GEW K G + A YEG W
Sbjct: 56 SGNTYQGYWAQGKRHGLGVET---KGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSN 112
Query: 69 GKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQ 106
G +DGYG + D T Y G W G + GYG++
Sbjct: 113 GLQDGYGVETYGDGGT------YQGQWAGGMRHGYGVR 144
Score = 47.4 bits (111), Expect = 1e-05
Identities = 21/57 (36%), Positives = 34/57 (59%)
Query: 112 EYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGM 168
E Y G+W +R+G+G SNG YEG+W N+K +G G +G++ EG ++ +
Sbjct: 279 ETYMGEWKNDKRNGFGVSERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNI 335
Score = 43.9 bits (102), Expect = 1e-04
Identities = 22/58 (37%), Positives = 32/58 (55%), Gaps = 1/58 (1%)
Query: 135 DIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFWVDNM 192
+ Y G+W+NDK NG G+ NG +YEG W ++G G D G EG + +N+
Sbjct: 279 ETYMGEWKNDKRNGFGVSERSNGMKYEGEWANNKRHGYGCTVFPD-GSKEEGKYKNNI 335
Score = 43.5 bits (101), Expect = 2e-04
Identities = 20/56 (35%), Positives = 30/56 (53%), Gaps = 1/56 (1%)
Query: 26 LRSQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPD 81
+ V A + Y+GEW+++ ++G G + G YEG+W KR GYG PD
Sbjct: 269 VEDHVDATTTETYMGEWKNDKRNGFGVSE-RSNGMKYEGEWANNKRHGYGCTVFPD 323
Score = 38.1 bits (87), Expect = 0.007
Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 3/63 (4%)
Query: 127 GRMYYSNGDIYEGQWENDKPNGEGMLRLKNG-NRYEGCWERGMKNGAGRFFHLDHGQLFE 185
GR + +G Y G WE K +G G+ G Y G W G + G + G ++
Sbjct: 4 GRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGG--YTWPSGNTYQ 61
Query: 186 GFW 188
G+W
Sbjct: 62 GYW 64
>gi|33359215 ALS2 C-terminal like isoform 1 [Homo sapiens]
Length = 953
Score = 67.0 bits (162), Expect = 1e-11
Identities = 44/134 (32%), Positives = 66/134 (49%), Gaps = 4/134 (2%)
Query: 36 DYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWW 95
D Y W + G G + +Y+G ++ G R G+G L Q R Y+G W
Sbjct: 407 DCYKCHWREGSMCGYGICEYSTD-EVYKGYFQEGLRHGFGVLESGPQAPQPFR--YTGHW 463
Query: 96 KGDKKSGYGIQFFGPK-EYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRL 154
+ ++SGYGI+ G + E Y G W QR G G M G Y+G ++ DK G G+L
Sbjct: 464 ERGQRSGYGIEEDGDRGERYIGMWQAGQRHGPGVMVTQAGVCYQGTFQADKTVGPGILLS 523
Query: 155 KNGNRYEGCWERGM 168
++ + YEG + R +
Sbjct: 524 EDDSLYEGTFTRDL 537
Score = 60.8 bits (146), Expect = 1e-09
Identities = 41/138 (29%), Positives = 63/138 (45%), Gaps = 15/138 (10%)
Query: 60 AIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPK-----EYY 114
A YEG+W G+ G GTL PD R + G + + G+GI+ + Y
Sbjct: 356 ATYEGEWCRGRPHGKGTLKWPDG------RNHVGNFCQGLEHGFGIRLLPQASEDKFDCY 409
Query: 115 EGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGML----RLKNGNRYEGCWERGMKN 170
+ W G+G YS ++Y+G ++ +G G+L + RY G WERG ++
Sbjct: 410 KCHWREGSMCGYGICEYSTDEVYKGYFQEGLRHGFGVLESGPQAPQPFRYTGHWERGQRS 469
Query: 171 GAGRFFHLDHGQLFEGFW 188
G G D G+ + G W
Sbjct: 470 GYGIEEDGDRGERYIGMW 487
Score = 60.5 bits (145), Expect = 1e-09
Identities = 50/186 (26%), Positives = 76/186 (40%), Gaps = 29/186 (15%)
Query: 38 YVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGK----------- 86
Y GEW HGKGT W G + G++ G G+G LP K
Sbjct: 358 YEGEWCRGRPHGKGTLKWPD-GRNHVGNFCQGLEHGFGIRLLPQASEDKFDCYKCHWREG 416
Query: 87 -------CR----RVYSGWWKGDKKSGYGIQFFGPKE----YYEGDWCGSQRSGWG-RMY 130
C VY G+++ + G+G+ GP+ Y G W QRSG+G
Sbjct: 417 SMCGYGICEYSTDEVYKGYFQEGLRHGFGVLESGPQAPQPFRYTGHWERGQRSGYGIEED 476
Query: 131 YSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFWVD 190
G+ Y G W+ + +G G++ + G Y+G ++ G G D L+EG +
Sbjct: 477 GDRGERYIGMWQAGQRHGPGVMVTQAGVCYQGTFQADKTVGPGILLSED-DSLYEGTFTR 535
Query: 191 NMAKCG 196
++ G
Sbjct: 536 DLTLMG 541
Score = 38.1 bits (87), Expect = 0.007
Identities = 33/133 (24%), Positives = 48/133 (36%), Gaps = 32/133 (24%)
Query: 17 WDRKAQRNGLRSQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGT 76
W+R QR+G + G+ Y+G W+ +HG G V
Sbjct: 463 WER-GQRSGYGIEEDGDRGERYIGMWQAGQRHGPGVMV---------------------- 499
Query: 77 LSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCGS-QRSGWGRMYYSNGD 135
Q G C Y G ++ DK G GI YEG + G G++ + NG
Sbjct: 500 -----TQAGVC---YQGTFQADKTVGPGILLSEDDSLYEGTFTRDLTLMGKGKVTFPNGF 551
Query: 136 IYEGQWENDKPNG 148
EG + + G
Sbjct: 552 TLEGSFGSGAGRG 564
>gi|225690502 junctophilin 4 [Homo sapiens]
Length = 628
Score = 62.8 bits (151), Expect = 3e-10
Identities = 40/140 (28%), Positives = 58/140 (41%), Gaps = 8/140 (5%)
Query: 34 NGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSG 93
+G YVG WE HG G Y G W G + G TG Y G
Sbjct: 11 DGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGF-ESLGVF------TGPGGHSYQG 63
Query: 94 WWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLR 153
W+ K+ G G++ + Y G+W G + G +G Y G W++ +G G
Sbjct: 64 HWQQGKREGLGVERKS-RWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTET 122
Query: 154 LKNGNRYEGCWERGMKNGAG 173
+G Y+G W+ G ++G G
Sbjct: 123 YSDGGTYQGQWQAGKRHGYG 142
Score = 53.1 bits (126), Expect = 2e-07
Identities = 23/69 (33%), Positives = 40/69 (57%)
Query: 85 GKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWEND 144
G VY+G W+ D++SG+G+ YEG+W G++R G+GR +G EG+++ +
Sbjct: 276 GSATEVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRN 335
Query: 145 KPNGEGMLR 153
+ G +R
Sbjct: 336 RLVHGGRVR 344
Score = 48.9 bits (115), Expect = 4e-06
Identities = 28/70 (40%), Positives = 36/70 (51%), Gaps = 9/70 (12%)
Query: 38 YVGEWEDNVKHGKGTQVWKK-KGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWK 96
Y GEW +K G VW+ G Y G WK G +DGYGT + D T Y G W+
Sbjct: 83 YRGEWLGGLKGRSG--VWESVSGLRYAGLWKDGFQDGYGTETYSDGGT------YQGQWQ 134
Query: 97 GDKKSGYGIQ 106
K+ GYG++
Sbjct: 135 AGKRHGYGVR 144
Score = 48.9 bits (115), Expect = 4e-06
Identities = 24/63 (38%), Positives = 35/63 (55%)
Query: 112 EYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNG 171
E Y G+W +RSG+G SNG YEG+W ++ +G G +G+R EG ++R
Sbjct: 280 EVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVH 339
Query: 172 AGR 174
GR
Sbjct: 340 GGR 342
Score = 45.4 bits (106), Expect = 4e-05
Identities = 26/64 (40%), Positives = 36/64 (56%), Gaps = 3/64 (4%)
Query: 27 RSQVY-AVNGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGT-LSLPDQQT 84
RS V+ +V+G Y G W+D + G GT+ + G Y+G W+ GKR GYG S+P Q
Sbjct: 94 RSGVWESVSGLRYAGLWKDGFQDGYGTETY-SDGGTYQGQWQAGKRHGYGVRQSVPYHQA 152
Query: 85 GKCR 88
R
Sbjct: 153 ALLR 156
Score = 40.0 bits (92), Expect = 0.002
Identities = 20/56 (35%), Positives = 30/56 (53%), Gaps = 3/56 (5%)
Query: 36 DYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPD--QQTGKCRR 89
+ Y GEW + + G G + G YEG+W +R GYG + PD ++ GK +R
Sbjct: 280 EVYAGEWRADRRSGFGVSQ-RSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKR 334
Score = 32.7 bits (73), Expect = 0.29
Identities = 17/63 (26%), Positives = 27/63 (42%), Gaps = 3/63 (4%)
Query: 127 GRMYYSNGDIYEGQWENDKPNGEGMLRLKNG-NRYEGCWERGMKNGAGRFFHLDHGQLFE 185
G+ + +G Y G WE + +G G+ Y GCW G ++ F G ++
Sbjct: 5 GKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLG--VFTGPGGHSYQ 62
Query: 186 GFW 188
G W
Sbjct: 63 GHW 65
>gi|225690500 junctophilin 4 [Homo sapiens]
Length = 628
Score = 62.8 bits (151), Expect = 3e-10
Identities = 40/140 (28%), Positives = 58/140 (41%), Gaps = 8/140 (5%)
Query: 34 NGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSG 93
+G YVG WE HG G Y G W G + G TG Y G
Sbjct: 11 DGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGF-ESLGVF------TGPGGHSYQG 63
Query: 94 WWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLR 153
W+ K+ G G++ + Y G+W G + G +G Y G W++ +G G
Sbjct: 64 HWQQGKREGLGVERKS-RWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTET 122
Query: 154 LKNGNRYEGCWERGMKNGAG 173
+G Y+G W+ G ++G G
Sbjct: 123 YSDGGTYQGQWQAGKRHGYG 142
Score = 53.1 bits (126), Expect = 2e-07
Identities = 23/69 (33%), Positives = 40/69 (57%)
Query: 85 GKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWEND 144
G VY+G W+ D++SG+G+ YEG+W G++R G+GR +G EG+++ +
Sbjct: 276 GSATEVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRN 335
Query: 145 KPNGEGMLR 153
+ G +R
Sbjct: 336 RLVHGGRVR 344
Score = 48.9 bits (115), Expect = 4e-06
Identities = 28/70 (40%), Positives = 36/70 (51%), Gaps = 9/70 (12%)
Query: 38 YVGEWEDNVKHGKGTQVWKK-KGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWK 96
Y GEW +K G VW+ G Y G WK G +DGYGT + D T Y G W+
Sbjct: 83 YRGEWLGGLKGRSG--VWESVSGLRYAGLWKDGFQDGYGTETYSDGGT------YQGQWQ 134
Query: 97 GDKKSGYGIQ 106
K+ GYG++
Sbjct: 135 AGKRHGYGVR 144
Score = 48.9 bits (115), Expect = 4e-06
Identities = 24/63 (38%), Positives = 35/63 (55%)
Query: 112 EYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNG 171
E Y G+W +RSG+G SNG YEG+W ++ +G G +G+R EG ++R
Sbjct: 280 EVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVH 339
Query: 172 AGR 174
GR
Sbjct: 340 GGR 342
Score = 45.4 bits (106), Expect = 4e-05
Identities = 26/64 (40%), Positives = 36/64 (56%), Gaps = 3/64 (4%)
Query: 27 RSQVY-AVNGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGT-LSLPDQQT 84
RS V+ +V+G Y G W+D + G GT+ + G Y+G W+ GKR GYG S+P Q
Sbjct: 94 RSGVWESVSGLRYAGLWKDGFQDGYGTETY-SDGGTYQGQWQAGKRHGYGVRQSVPYHQA 152
Query: 85 GKCR 88
R
Sbjct: 153 ALLR 156
Score = 40.0 bits (92), Expect = 0.002
Identities = 20/56 (35%), Positives = 30/56 (53%), Gaps = 3/56 (5%)
Query: 36 DYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPD--QQTGKCRR 89
+ Y GEW + + G G + G YEG+W +R GYG + PD ++ GK +R
Sbjct: 280 EVYAGEWRADRRSGFGVSQ-RSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKR 334
Score = 32.7 bits (73), Expect = 0.29
Identities = 17/63 (26%), Positives = 27/63 (42%), Gaps = 3/63 (4%)
Query: 127 GRMYYSNGDIYEGQWENDKPNGEGMLRLKNG-NRYEGCWERGMKNGAGRFFHLDHGQLFE 185
G+ + +G Y G WE + +G G+ Y GCW G ++ F G ++
Sbjct: 5 GKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLG--VFTGPGGHSYQ 62
Query: 186 GFW 188
G W
Sbjct: 63 GHW 65
>gi|149999376 MORN repeat containing 4 [Homo sapiens]
Length = 146
Score = 61.6 bits (148), Expect = 6e-10
Identities = 30/75 (40%), Positives = 45/75 (60%), Gaps = 1/75 (1%)
Query: 112 EYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNG 171
E Y G+W +R G+G++ +++G Y G +EN NG G+L +G+RYEG + +G NG
Sbjct: 14 EEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNG 73
Query: 172 AGRFFHLDHGQLFEG 186
G F D+ FEG
Sbjct: 74 VGVFIRYDN-MTFEG 87
Score = 56.2 bits (134), Expect = 2e-08
Identities = 33/111 (29%), Positives = 56/111 (50%), Gaps = 10/111 (9%)
Query: 59 GAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDW 118
G Y G+WK G+R G+G L D T Y G ++ +G+G+ F YEG++
Sbjct: 13 GEEYRGEWKEGRRHGFGQLMFADGGT------YLGHFENGLFNGFGVLTFSDGSRYEGEF 66
Query: 119 CGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGN----RYEGCWE 165
+ +G G + +EG+++N + +G G+L +G+ R EG +E
Sbjct: 67 AQGKFNGVGVFIRYDNMTFEGEFKNGRVDGFGLLTFPDGSHGIPRNEGLFE 117
Score = 48.5 bits (114), Expect = 5e-06
Identities = 33/116 (28%), Positives = 53/116 (45%), Gaps = 7/116 (6%)
Query: 91 YSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEG 150
Y G WK ++ G+G F Y G + +G+G + +S+G YEG++ K NG G
Sbjct: 16 YRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVG 75
Query: 151 MLRLKNGNRYEGCWERGMKNGAGRFFHLD--HG-----QLFEGFWVDNMAKCGTMI 199
+ + +EG ++ G +G G D HG LFE + KC ++
Sbjct: 76 VFIRYDNMTFEGEFKNGRVDGFGLLTFPDGSHGIPRNEGLFENNKLLRREKCSAIV 131
Score = 46.6 bits (109), Expect = 2e-05
Identities = 32/116 (27%), Positives = 56/116 (48%), Gaps = 11/116 (9%)
Query: 34 NGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSG 93
+G+ Y GEW++ +HG G Q+ G Y G ++ G +G+G L+ D Y G
Sbjct: 12 SGEEYRGEWKEGRRHGFG-QLMFADGGTYLGHFENGLFNGFGVLTFSDGSR------YEG 64
Query: 94 WWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGD----IYEGQWENDK 145
+ K +G G+ +EG++ + G+G + + +G EG +EN+K
Sbjct: 65 EFAQGKFNGVGVFIRYDNMTFEGEFKNGRVDGFGLLTFPDGSHGIPRNEGLFENNK 120
Score = 43.9 bits (102), Expect = 1e-04
Identities = 22/60 (36%), Positives = 32/60 (53%), Gaps = 1/60 (1%)
Query: 127 GRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEG 186
G YS+G+ Y G+W+ + +G G L +G Y G +E G+ NG G D G +EG
Sbjct: 6 GSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSD-GSRYEG 64
Score = 28.9 bits (63), Expect = 4.2
Identities = 15/49 (30%), Positives = 21/49 (42%), Gaps = 8/49 (16%)
Query: 149 EGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQ--------LFEGFWV 189
+G +G Y G W+ G ++G G+ D G LF GF V
Sbjct: 5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGV 53
>gi|30520314 MORN repeat containing 4 [Homo sapiens]
Length = 146
Score = 61.6 bits (148), Expect = 6e-10
Identities = 30/75 (40%), Positives = 45/75 (60%), Gaps = 1/75 (1%)
Query: 112 EYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNG 171
E Y G+W +R G+G++ +++G Y G +EN NG G+L +G+RYEG + +G NG
Sbjct: 14 EEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNG 73
Query: 172 AGRFFHLDHGQLFEG 186
G F D+ FEG
Sbjct: 74 VGVFIRYDN-MTFEG 87
Score = 56.2 bits (134), Expect = 2e-08
Identities = 33/111 (29%), Positives = 56/111 (50%), Gaps = 10/111 (9%)
Query: 59 GAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDW 118
G Y G+WK G+R G+G L D T Y G ++ +G+G+ F YEG++
Sbjct: 13 GEEYRGEWKEGRRHGFGQLMFADGGT------YLGHFENGLFNGFGVLTFSDGSRYEGEF 66
Query: 119 CGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGN----RYEGCWE 165
+ +G G + +EG+++N + +G G+L +G+ R EG +E
Sbjct: 67 AQGKFNGVGVFIRYDNMTFEGEFKNGRVDGFGLLTFPDGSHGIPRNEGLFE 117
Score = 48.5 bits (114), Expect = 5e-06
Identities = 33/116 (28%), Positives = 53/116 (45%), Gaps = 7/116 (6%)
Query: 91 YSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEG 150
Y G WK ++ G+G F Y G + +G+G + +S+G YEG++ K NG G
Sbjct: 16 YRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVG 75
Query: 151 MLRLKNGNRYEGCWERGMKNGAGRFFHLD--HG-----QLFEGFWVDNMAKCGTMI 199
+ + +EG ++ G +G G D HG LFE + KC ++
Sbjct: 76 VFIRYDNMTFEGEFKNGRVDGFGLLTFPDGSHGIPRNEGLFENNKLLRREKCSAIV 131
Score = 46.6 bits (109), Expect = 2e-05
Identities = 32/116 (27%), Positives = 56/116 (48%), Gaps = 11/116 (9%)
Query: 34 NGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSG 93
+G+ Y GEW++ +HG G Q+ G Y G ++ G +G+G L+ D Y G
Sbjct: 12 SGEEYRGEWKEGRRHGFG-QLMFADGGTYLGHFENGLFNGFGVLTFSDGSR------YEG 64
Query: 94 WWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGD----IYEGQWENDK 145
+ K +G G+ +EG++ + G+G + + +G EG +EN+K
Sbjct: 65 EFAQGKFNGVGVFIRYDNMTFEGEFKNGRVDGFGLLTFPDGSHGIPRNEGLFENNK 120
Score = 43.9 bits (102), Expect = 1e-04
Identities = 22/60 (36%), Positives = 32/60 (53%), Gaps = 1/60 (1%)
Query: 127 GRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEG 186
G YS+G+ Y G+W+ + +G G L +G Y G +E G+ NG G D G +EG
Sbjct: 6 GSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSD-GSRYEG 64
Score = 28.9 bits (63), Expect = 4.2
Identities = 15/49 (30%), Positives = 21/49 (42%), Gaps = 8/49 (16%)
Query: 149 EGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQ--------LFEGFWV 189
+G +G Y G W+ G ++G G+ D G LF GF V
Sbjct: 5 KGSFTYSSGEEYRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGV 53
>gi|29893812 junctophilin 2 isoform 2 [Homo sapiens]
Length = 129
Score = 60.5 bits (145), Expect = 1e-09
Identities = 38/118 (32%), Positives = 52/118 (44%), Gaps = 9/118 (7%)
Query: 34 NGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSG 93
+G Y G WE HG G K Y G W FG + G + P T + G
Sbjct: 10 DGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFG-FEVAGVYTWPSGNT------FEG 62
Query: 94 WWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWG-RMYYSNGDIYEGQWENDKPNGEG 150
+W K+ G GI+ G + Y+G+W + +G R S+G YEG W N +G G
Sbjct: 63 YWSQGKRHGLGIETKG-RWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYG 119
Score = 50.4 bits (119), Expect = 1e-06
Identities = 33/101 (32%), Positives = 48/101 (47%), Gaps = 7/101 (6%)
Query: 91 YSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGW---GRMYYSNGDIYEGQWENDKPN 147
Y G W+G K G+G+ GPK +G++ GS G+ G + +G+ +EG W K +
Sbjct: 14 YCGGWEGGKAHGHGL-CTGPKG--QGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRH 70
Query: 148 GEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFW 188
G G + K Y+G W G K G G +EG W
Sbjct: 71 GLG-IETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTW 110
Score = 41.6 bits (96), Expect = 6e-04
Identities = 25/73 (34%), Positives = 37/73 (50%), Gaps = 4/73 (5%)
Query: 10 SESLWKGWDRKAQRNGLRSQVYAVNGDY-YVGEWEDNVKHGKGTQVWKKKGAIYEGDWKF 68
S + ++G+ + +R+GL + G + Y GEW K G + GA YEG W
Sbjct: 56 SGNTFEGYWSQGKRHGLGIET---KGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNN 112
Query: 69 GKRDGYGTLSLPD 81
G +DGYGT + D
Sbjct: 113 GLQDGYGTETYAD 125
Score = 38.5 bits (88), Expect = 0.005
Identities = 20/63 (31%), Positives = 27/63 (42%), Gaps = 3/63 (4%)
Query: 127 GRMYYSNGDIYEGQWENDKPNGEGMLRLKNG-NRYEGCWERGMKNGAGRFFHLDHGQLFE 185
GR + +G Y G WE K +G G+ G Y G W G + + G FE
Sbjct: 4 GRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFE--VAGVYTWPSGNTFE 61
Query: 186 GFW 188
G+W
Sbjct: 62 GYW 64
>gi|18139549 SET domain-containing protein 7 [Homo sapiens]
Length = 366
Score = 47.4 bits (111), Expect = 1e-05
Identities = 21/91 (23%), Positives = 48/91 (52%)
Query: 102 GYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYE 161
G+ + + +EG++ +++G G+ ++ +G EG + +D G+G+ ++G +
Sbjct: 24 GFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQ 83
Query: 162 GCWERGMKNGAGRFFHLDHGQLFEGFWVDNM 192
G + G NG + + D +F+G + DN+
Sbjct: 84 GTYVDGELNGPAQEYDTDGRLIFKGQYKDNI 114
Score = 39.3 bits (90), Expect = 0.003
Identities = 21/55 (38%), Positives = 33/55 (60%), Gaps = 2/55 (3%)
Query: 138 EGQWENDK-PNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFWVDN 191
EG ++D P+G + + +R+EG + G KNG G+FF D G EG++VD+
Sbjct: 13 EGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFD-GSTLEGYYVDD 66
>gi|75750529 ankyrin repeat and MYND domain containing 1 isoform 1
[Homo sapiens]
Length = 941
Score = 42.4 bits (98), Expect = 4e-04
Identities = 27/106 (25%), Positives = 49/106 (46%), Gaps = 7/106 (6%)
Query: 61 IYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCG 120
+Y+G++ + GYG S P ++ Y G + D G G + + G +
Sbjct: 1 MYQGEFGLNMKLGYGKFSWPTGES------YHGQFYRDHCHGLGTYMWPDGSSFTGTFYL 54
Query: 121 SQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWER 166
S R G+G MY +++G ++ D+ G G+ +G++ G W R
Sbjct: 55 SHREGYGTMYMKT-RLFQGLYKADQRFGPGVETYPDGSQDVGLWFR 99
Score = 42.4 bits (98), Expect = 4e-04
Identities = 24/88 (27%), Positives = 43/88 (48%), Gaps = 8/88 (9%)
Query: 35 GDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGW 94
G+ Y G++ + HG GT +W G+ + G + R+GYGT+ + R++ G
Sbjct: 22 GESYHGQFYRDHCHGLGTYMWPD-GSSFTGTFYLSHREGYGTMYMKT-------RLFQGL 73
Query: 95 WKGDKKSGYGIQFFGPKEYYEGDWCGSQ 122
+K D++ G G++ + G W Q
Sbjct: 74 YKADQRFGPGVETYPDGSQDVGLWFREQ 101
Score = 36.2 bits (82), Expect = 0.026
Identities = 18/75 (24%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 114 YEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAG 173
Y+G++ + + G+G+ + G+ Y GQ+ D +G G +G+ + G + + G G
Sbjct: 2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 61
Query: 174 RFFHLDHGQLFEGFW 188
+ +LF+G +
Sbjct: 62 TMYM--KTRLFQGLY 74
Score = 29.6 bits (65), Expect = 2.4
Identities = 25/113 (22%), Positives = 46/113 (40%), Gaps = 1/113 (0%)
Query: 90 VYSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGE 149
+Y G + + K GYG + E Y G + G G + +G + G + G
Sbjct: 1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGY 60
Query: 150 GMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFWVDNMAKCGTMIDFG 202
G + +K ++G ++ + G G + D Q ++ + + K T I G
Sbjct: 61 GTMYMKT-RLFQGLYKADQRFGPGVETYPDGSQDVGLWFREQLIKLCTQIPSG 112
>gi|75750531 ankyrin repeat and MYND domain containing 1 isoform 2
[Homo sapiens]
Length = 717
Score = 39.3 bits (90), Expect = 0.003
Identities = 32/126 (25%), Positives = 53/126 (42%), Gaps = 12/126 (9%)
Query: 43 EDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSG 102
E ++ +G Q W+ G +Y+G++ + GYG S P ++ Y G + D G
Sbjct: 73 ESYIQLVQGVQEWQD-GCMYQGEFGLNMKLGYGKFSWPTGES------YHGQFYRDHCHG 125
Query: 103 YGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEG 162
G + + G + S R G+G MY +++ ND N L L G
Sbjct: 126 LGTYMWPDGSSFTGTFYLSHREGYGTMYMKT-RLFQTHCHNDIVN----LLLDCGADVNK 180
Query: 163 CWERGM 168
C + G+
Sbjct: 181 CSDEGL 186
Score = 35.8 bits (81), Expect = 0.034
Identities = 17/73 (23%), Positives = 36/73 (49%)
Query: 104 GIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGC 163
G+Q + Y+G++ + + G+G+ + G+ Y GQ+ D +G G +G+ + G
Sbjct: 81 GVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGT 140
Query: 164 WERGMKNGAGRFF 176
+ + G G +
Sbjct: 141 FYLSHREGYGTMY 153
Score = 32.7 bits (73), Expect = 0.29
Identities = 15/43 (34%), Positives = 25/43 (58%), Gaps = 1/43 (2%)
Query: 35 GDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTL 77
G+ Y G++ + HG GT +W G+ + G + R+GYGT+
Sbjct: 111 GESYHGQFYRDHCHGLGTYMW-PDGSSFTGTFYLSHREGYGTM 152
Score = 28.5 bits (62), Expect = 5.4
Identities = 17/72 (23%), Positives = 30/72 (41%)
Query: 127 GRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEG 186
G + +G +Y+G++ + G G G Y G + R +G G + D
Sbjct: 81 GVQEWQDGCMYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGT 140
Query: 187 FWVDNMAKCGTM 198
F++ + GTM
Sbjct: 141 FYLSHREGYGTM 152
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 38.9 bits (89), Expect = 0.004
Identities = 39/152 (25%), Positives = 66/152 (43%), Gaps = 16/152 (10%)
Query: 35 GDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGW 94
G+ GE E+ GKG +++G EG+ + + +G G +++ G+ G
Sbjct: 842 GEEEEGEGEEEEGEGKG----EEEGEEGEGEEEGEEGEGEG-----EEEEGEGEGEEEGE 892
Query: 95 WKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRL 154
+G+++ G G + EG+ G + G G+ G+ EG+ E ++ GEG
Sbjct: 893 GEGEEEEGEG------EGEEEGEGEGEEEEGEGKGE-EEGEEGEGEGEEEEGEGEGEDGE 945
Query: 155 KNGNRYEGCWERGMKNGAGRFFHLDHGQLFEG 186
G EG WE + G G G+ EG
Sbjct: 946 GEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEG 977
>gi|224282170 MORN repeat containing 2 [Homo sapiens]
Length = 79
Score = 38.5 bits (88), Expect = 0.005
Identities = 16/52 (30%), Positives = 30/52 (57%)
Query: 124 SGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRF 175
+G+GR+ + +G +YEGQ++++ +G G NG +Y G + G G +
Sbjct: 2 NGFGRLEHFSGAVYEGQFKDNMFHGLGTYTFPNGAKYTGNFNENRVEGEGEY 53
Score = 30.8 bits (68), Expect = 1.1
Identities = 15/42 (35%), Positives = 25/42 (59%), Gaps = 1/42 (2%)
Query: 34 NGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYG 75
+G Y G+++DN+ HG GT + GA Y G++ + +G G
Sbjct: 11 SGAVYEGQFKDNMFHGLGTYTF-PNGAKYTGNFNENRVEGEG 51
>gi|223278407 MORN repeat containing 5 [Homo sapiens]
Length = 161
Score = 36.2 bits (82), Expect = 0.026
Identities = 17/64 (26%), Positives = 33/64 (51%), Gaps = 2/64 (3%)
Query: 105 IQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCW 164
+++ G K Y G++ + G + IY G+ ++ +GEG L +G++Y+ W
Sbjct: 1 MEYTGSK--YIGEYVDGRMEGKAKYILPTETIYVGEMKDGMFHGEGTLYFPSGSQYDAIW 58
Query: 165 ERGM 168
E G+
Sbjct: 59 ENGL 62
Score = 31.6 bits (70), Expect = 0.64
Identities = 26/98 (26%), Positives = 36/98 (36%), Gaps = 9/98 (9%)
Query: 35 GDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGW 94
G Y+GE+ D GK + + IY G+ K G G GTL P Y
Sbjct: 5 GSKYIGEYVDGRMEGKAKYILPTE-TIYVGEMKDGMFHGEGTLYFPSGSQ------YDAI 57
Query: 95 WKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYS 132
W+ F Y E +W G+ R +Y+
Sbjct: 58 WENGLAIKGTYTFSDGLHYDEKNW--HYCDGYDRRFYT 93
>gi|110556636 tankyrase 1-binding protein 1 [Homo sapiens]
Length = 1729
Score = 34.7 bits (78), Expect = 0.076
Identities = 31/94 (32%), Positives = 40/94 (42%), Gaps = 17/94 (18%)
Query: 65 DWKFGKRDGYGTLS-----LPDQQTGK--------CRRVYSGWWKGDKKSGYGIQFFGPK 111
DW+F KRD GT S L DQ+ GK R V G W+ K+ G + +
Sbjct: 843 DWEFRKRDSQGTYSSRDAELQDQEFGKRDSLGTYSSRDVSLGDWEFGKRDSLGA--YASQ 900
Query: 112 EYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDK 145
+ E +R GR YS+ D E WE K
Sbjct: 901 DANEQGQDLGKRDHHGR--YSSQDADEQDWEFQK 932
Score = 28.5 bits (62), Expect = 5.4
Identities = 28/90 (31%), Positives = 36/90 (40%), Gaps = 27/90 (30%)
Query: 64 GDWKFGKRDGYGTLSLPD-----QQTGKCRRVYSGW----------WKGDKK----SGYG 104
GDW+FGKRD G + D Q GK R + G W+ K+ YG
Sbjct: 884 GDWEFGKRDSLGAYASQDANEQGQDLGK--RDHHGRYSSQDADEQDWEFQKRDVSLGTYG 941
Query: 105 IQFFGPKEYYEGDWCGSQRSGWGRMYYSNG 134
+ P+E G +S W R Y S G
Sbjct: 942 SRAAEPQEQEFG------KSAWIRDYSSGG 965
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 34.3 bits (77), Expect = 0.099
Identities = 37/156 (23%), Positives = 63/156 (40%), Gaps = 26/156 (16%)
Query: 11 ESLWKGWDRKAQRNGLRSQVYAVNGDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGK 70
++L GW+++ NG +VY V+ + WE + G W+K+ + +F
Sbjct: 300 DALPAGWEQRELPNG---RVYYVDHNTKTTTWERPLPPG-----WEKRT---DPRGRFYY 348
Query: 71 RDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEG-------DWCGSQR 123
D + + T + R Y W + +Q F + Y+ D G
Sbjct: 349 VDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLP 408
Query: 124 SGW------GRMYYSNGDIYEGQWENDKPNGEGMLR 153
GW GR+YY N + QWE+ P +GM++
Sbjct: 409 PGWEKRQDNGRVYYVNHNTRTTQWED--PRTQGMIQ 442
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 28.5 bits (62), Expect = 5.4
Identities = 12/35 (34%), Positives = 20/35 (57%), Gaps = 3/35 (8%)
Query: 16 GWDRKAQRNGLRSQVYAVNGDYYVGEWEDNVKHGK 50
GW+++ NG +VY VN + + +WED G+
Sbjct: 402 GWEKRTDSNG---RVYFVNHNTRITQWEDPRSQGQ 433
>gi|28559065 DNA cytosine-5 methyltransferase 3 beta isoform 6 [Homo
sapiens]
Length = 845
Score = 28.5 bits (62), Expect = 5.4
Identities = 17/52 (32%), Positives = 28/52 (53%), Gaps = 1/52 (1%)
Query: 7 PKKSESLWKGWDRKAQRNGLRS-QVYAVNGDYYVGEWEDNVKHGKGTQVWKK 57
P+ S + + + +Q+ G+ S QV A +GD E++D + G G VW K
Sbjct: 193 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGK 244
>gi|28559063 DNA cytosine-5 methyltransferase 3 beta isoform 3 [Homo
sapiens]
Length = 770
Score = 28.5 bits (62), Expect = 5.4
Identities = 17/52 (32%), Positives = 28/52 (53%), Gaps = 1/52 (1%)
Query: 7 PKKSESLWKGWDRKAQRNGLRS-QVYAVNGDYYVGEWEDNVKHGKGTQVWKK 57
P+ S + + + +Q+ G+ S QV A +GD E++D + G G VW K
Sbjct: 181 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGK 232
>gi|28559061 DNA cytosine-5 methyltransferase 3 beta isoform 2 [Homo
sapiens]
Length = 833
Score = 28.5 bits (62), Expect = 5.4
Identities = 17/52 (32%), Positives = 28/52 (53%), Gaps = 1/52 (1%)
Query: 7 PKKSESLWKGWDRKAQRNGLRS-QVYAVNGDYYVGEWEDNVKHGKGTQVWKK 57
P+ S + + + +Q+ G+ S QV A +GD E++D + G G VW K
Sbjct: 181 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGK 232
>gi|5901940 DNA cytosine-5 methyltransferase 3 beta isoform 1 [Homo
sapiens]
Length = 853
Score = 28.5 bits (62), Expect = 5.4
Identities = 17/52 (32%), Positives = 28/52 (53%), Gaps = 1/52 (1%)
Query: 7 PKKSESLWKGWDRKAQRNGLRS-QVYAVNGDYYVGEWEDNVKHGKGTQVWKK 57
P+ S + + + +Q+ G+ S QV A +GD E++D + G G VW K
Sbjct: 181 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGK 232
>gi|148806908 fibronectin type III domain containing 1 [Homo sapiens]
Length = 1894
Score = 28.5 bits (62), Expect = 5.4
Identities = 18/62 (29%), Positives = 28/62 (45%), Gaps = 3/62 (4%)
Query: 121 SQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGM-KNGAGRFFHLD 179
S R G+ G + G N KPNG+ ++ G ++ +RG+ N GR+
Sbjct: 1319 SYRQGYNGRPNVEGKVLPGS--NGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDS 1376
Query: 180 HG 181
HG
Sbjct: 1377 HG 1378
>gi|208022678 hypothetical protein LOC374877 [Homo sapiens]
Length = 505
Score = 28.5 bits (62), Expect = 5.4
Identities = 40/173 (23%), Positives = 60/173 (34%), Gaps = 39/173 (22%)
Query: 66 WKFGKRDGYGTL----SLPDQQTGKCRRVYSGWWKGDKKSGYGIQFFGPKEYYEGDWCGS 121
W + ++DG +LP +C+R SG GD K Y G C
Sbjct: 200 WDYTRQDGTSYQRQFQALPGPPALRCKRASSGVELGDCKISY------------GSTCSE 247
Query: 122 QRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRF------ 175
Q+ Y D+ E ++ DK + N +G + R A F
Sbjct: 248 QKQA-----YRPQDLPEDRY--DKAQATAHIHCVNIRPGDGLF-RDRTTKAEHFYAREPE 299
Query: 176 -FHLDHGQ-----LFEGFWVDNMAKCGTMIDFGRDEAPEPTQFP---IPEVKI 219
F L H Q + +G W T + + + P PTQ P +P K+
Sbjct: 300 PFVLHHDQTPESHILKGNWCPGPGSLDTFMQYFYGQPPPPTQPPSRHVPHEKL 352
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.140 0.473
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,965,940
Number of Sequences: 37866
Number of extensions: 561810
Number of successful extensions: 1286
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 924
Number of HSP's gapped (non-prelim): 162
length of query: 240
length of database: 18,247,518
effective HSP length: 99
effective length of query: 141
effective length of database: 14,498,784
effective search space: 2044328544
effective search space used: 2044328544
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.