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Search of human proteins with 5031937
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5031937 calcium binding and coiled-coil domain 2 [Homo
sapiens]
(446 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5031937 calcium binding and coiled-coil domain 2 [Homo sapiens] 913 0.0
gi|119943086 Tax1 (human T-cell leukemia virus type I) binding p... 160 2e-39
gi|21361682 Tax1 (human T-cell leukemia virus type I) binding pr... 160 2e-39
gi|14149742 coiled-coil transcriptional coactivator isoform 1 [H... 129 4e-30
gi|219521893 coiled-coil transcriptional coactivator isoform 2 [... 81 2e-15
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 75 9e-14
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 75 9e-14
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 72 1e-12
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 69 9e-12
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 69 9e-12
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 69 9e-12
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 69 1e-11
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 68 1e-11
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 68 2e-11
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 67 3e-11
gi|55770834 centromere protein F [Homo sapiens] 67 3e-11
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 67 3e-11
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 67 3e-11
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 67 3e-11
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 67 3e-11
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 67 3e-11
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 66 7e-11
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 65 2e-10
gi|16262452 cingulin [Homo sapiens] 64 2e-10
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 64 3e-10
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 64 4e-10
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 64 4e-10
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 63 5e-10
gi|71061468 centromere protein E [Homo sapiens] 63 5e-10
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 63 6e-10
>gi|5031937 calcium binding and coiled-coil domain 2 [Homo sapiens]
Length = 446
Score = 913 bits (2359), Expect = 0.0
Identities = 446/446 (100%), Positives = 446/446 (100%)
Query: 1 MEETIKDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFR 60
MEETIKDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFR
Sbjct: 1 MEETIKDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFR 60
Query: 61 VGWKTTREYYTFMWVTLPIDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGAS 120
VGWKTTREYYTFMWVTLPIDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGAS
Sbjct: 61 VGWKTTREYYTFMWVTLPIDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGAS 120
Query: 121 IPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKK 180
IPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKK
Sbjct: 121 IPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKK 180
Query: 181 QEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQ 240
QEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQ
Sbjct: 181 QEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQ 240
Query: 241 EKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQ 300
EKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQ
Sbjct: 241 EKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQ 300
Query: 301 QELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQV 360
QELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQV
Sbjct: 301 QELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQV 360
Query: 361 PTSDEGGARQNPGLAYGNPYSGIQESSSPSPLSIKKCPICKADDICDHTLEQQQMQPLCF 420
PTSDEGGARQNPGLAYGNPYSGIQESSSPSPLSIKKCPICKADDICDHTLEQQQMQPLCF
Sbjct: 361 PTSDEGGARQNPGLAYGNPYSGIQESSSPSPLSIKKCPICKADDICDHTLEQQQMQPLCF 420
Query: 421 NCPICDKIFPATEKQIFEDHVFCHSL 446
NCPICDKIFPATEKQIFEDHVFCHSL
Sbjct: 421 NCPICDKIFPATEKQIFEDHVFCHSL 446
>gi|119943086 Tax1 (human T-cell leukemia virus type I) binding
protein 1 isoform b [Homo sapiens]
Length = 747
Score = 160 bits (405), Expect = 2e-39
Identities = 107/320 (33%), Positives = 164/320 (51%), Gaps = 35/320 (10%)
Query: 13 VLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTF 72
V L +F+ VIF +V K Y+P + CHYT T + P KDW+GIF+VGW T R+YYTF
Sbjct: 7 VPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTF 66
Query: 73 MWVTLPIDLNNKSAKQQEVQFKAYYLPKDD-EYYQFCYVDEDGVVRGASIPFQFR----- 126
+W +P S + F+ YYLP DD E+YQFCYV G +RGAS PFQFR
Sbjct: 67 LWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPV 126
Query: 127 -------PENEEDILVVTTQG-----EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQ 174
E D+LVVTT+ ++E+ + +EL K L+ L++Q M+
Sbjct: 127 EELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRME 186
Query: 175 AELQKKQEELETLQSINKKLELKVKEQKDYWETELLQ-LKEQNQKMSSENEKMGIRVDQL 233
EL ++E + LQ+ K L TE+ Q LK +N++ + QL
Sbjct: 187 RELNHEKERCDQLQAEQKGL------------TEVTQSLKMENEEFKKRFSDATSKAHQL 234
Query: 234 QAQL-STQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQN 292
+ + S K +EK + D K ++L++ + E + L L + KD+K+L + + +
Sbjct: 235 EEDIVSVTHKAIEKETELDSLK-DKLKKAQHEREQLECQL-KTEKDEKELYKVHLKNTEI 292
Query: 293 ETTAMKKQQELMDENFDLSK 312
E T + + + + +N D +K
Sbjct: 293 ENTKLMSEVQTL-KNLDGNK 311
>gi|21361682 Tax1 (human T-cell leukemia virus type I) binding
protein 1 isoform a [Homo sapiens]
Length = 789
Score = 160 bits (405), Expect = 2e-39
Identities = 107/320 (33%), Positives = 164/320 (51%), Gaps = 35/320 (10%)
Query: 13 VLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTF 72
V L +F+ VIF +V K Y+P + CHYT T + P KDW+GIF+VGW T R+YYTF
Sbjct: 7 VPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTF 66
Query: 73 MWVTLPIDLNNKSAKQQEVQFKAYYLPKDD-EYYQFCYVDEDGVVRGASIPFQFR----- 126
+W +P S + F+ YYLP DD E+YQFCYV G +RGAS PFQFR
Sbjct: 67 LWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPV 126
Query: 127 -------PENEEDILVVTTQG-----EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQ 174
E D+LVVTT+ ++E+ + +EL K L+ L++Q M+
Sbjct: 127 EELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRME 186
Query: 175 AELQKKQEELETLQSINKKLELKVKEQKDYWETELLQ-LKEQNQKMSSENEKMGIRVDQL 233
EL ++E + LQ+ K L TE+ Q LK +N++ + QL
Sbjct: 187 RELNHEKERCDQLQAEQKGL------------TEVTQSLKMENEEFKKRFSDATSKAHQL 234
Query: 234 QAQL-STQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQN 292
+ + S K +EK + D K ++L++ + E + L L + KD+K+L + + +
Sbjct: 235 EEDIVSVTHKAIEKETELDSLK-DKLKKAQHEREQLECQL-KTEKDEKELYKVHLKNTEI 292
Query: 293 ETTAMKKQQELMDENFDLSK 312
E T + + + + +N D +K
Sbjct: 293 ENTKLMSEVQTL-KNLDGNK 311
Score = 32.3 bits (72), Expect = 0.89
Identities = 67/352 (19%), Positives = 137/352 (38%), Gaps = 50/352 (14%)
Query: 126 RPENEEDILVVTTQGEVEEIE-------QHNKELCKENQELKDSCISLQKQNSDMQAELQ 178
+ +++ D L + EVE+++ H KE KE Q L+ L Q+++
Sbjct: 419 KDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFT 478
Query: 179 KKQEELETLQSINKKLE-------LKVKEQKDYWETELL-----QLKEQNQKMSSENEKM 226
KK + + + + + VK E + Q+ E ++++ + EK
Sbjct: 479 KKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKY 538
Query: 227 GIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTV 286
LQ + + K ++L + + EQ+ K +++ L L E + + K+L++++
Sbjct: 539 NKCKQLLQDEKAKCNKYADELAKMELKWKEQV----KIAENVKLELAEVQDNYKELKRSL 594
Query: 287 EQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLL 346
E A +K + ++ K SE L + L+ N +E
Sbjct: 595 EN------PAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGA 648
Query: 347 --SYMGLDFNSLPYQVPT--SDEGGARQNPGLAYGNPYSGIQESS-SPSPLSIKKCPICK 401
++ + P +VP+ ++ P + P G+++S S ++ P
Sbjct: 649 DGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRP-DGLEDSEDSKEDENVPTAPDPP 707
Query: 402 ADDICDHTLEQQQMQPLCFN--------CPICDKIFPAT-EKQIFEDHVFCH 444
+ + H CF+ CP+C+ +FP ++ FE+HV H
Sbjct: 708 SQHLRGHGTG------FCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESH 753
>gi|14149742 coiled-coil transcriptional coactivator isoform 1 [Homo
sapiens]
Length = 691
Score = 129 bits (325), Expect = 4e-30
Identities = 101/352 (28%), Positives = 173/352 (49%), Gaps = 52/352 (14%)
Query: 23 VIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPIDLN 82
V F +V + YIP V CHYT +P DWIGIF+V R+Y+TF+W ++P
Sbjct: 15 VNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTT 74
Query: 83 NKSAKQQEVQFKAYYLPKDD-EYYQFCYVDEDGVVRGASIPFQF---RPENE-------- 130
+ S VQF+A YLPK + YQF YV+ G V G S PFQF RP +E
Sbjct: 75 DGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFREPRPMDELVTLEEAD 134
Query: 131 --EDILVV-----TTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAEL-QKKQE 182
DIL+V Q +++E +Q +L + +L+ L+ + +++ L +QE
Sbjct: 135 GGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQE 194
Query: 183 ELETLQ----------SINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQ 232
E ++ I ++ ++ ++Q D+ +L+L++ Q +S + + +D+
Sbjct: 195 HTELMEQYKGISRSHGEITEERDILSRQQGDH-VARILELEDDIQTISEKVLTKEVELDR 253
Query: 233 LQAQLSTQEKEMEKL------VQGDQDKTE-QLEQLKKENDHLFLSLTEQRKDQKKLEQT 285
L+ + +E EKL VQ D++++E +L+ ++EN HL L L E + Q++
Sbjct: 254 LRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQ 313
Query: 286 VEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDL 337
+++K K ++ D +R++E L+ KE+L G +L
Sbjct: 314 AQRLKD-------KVAQMKDTLGQAQQRVAE-------LEPLKEQLRGAQEL 351
Score = 45.4 bits (106), Expect = 1e-04
Identities = 33/143 (23%), Positives = 71/143 (49%), Gaps = 12/143 (8%)
Query: 175 AELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQ 234
AEL + + E+ + +L L +KE+K W E L Q + +E +K+
Sbjct: 378 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL---QSVEAEKDKI-------- 426
Query: 235 AQLSTQEKEMEKLVQGDQDKTEQLE-QLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNE 293
+LS + +EK VQ ++ + + + +L +E D + L+E +++ +L + +++ +
Sbjct: 427 LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEK 486
Query: 294 TTAMKKQQELMDENFDLSKRLSE 316
+++QEL++ L RL +
Sbjct: 487 EQLQEEKQELLEYMRKLEARLEK 509
Score = 41.6 bits (96), Expect = 0.001
Identities = 54/283 (19%), Positives = 110/283 (38%), Gaps = 75/283 (26%)
Query: 128 ENEEDIL-----VVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQE 182
E E+DI V+T + E++ + K L +E ++L Q ++QA+ ++ +
Sbjct: 232 ELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLG-------QLKEVQADKEQSEA 284
Query: 183 ELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMG------IRVDQLQAQ 236
EL+ Q N L L +KE K + E + Q + K++ + +G ++ L+ Q
Sbjct: 285 ELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQ 344
Query: 237 L--------STQEKEM------------------------------------------EK 246
L S+Q+K E+
Sbjct: 345 LRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEE 404
Query: 247 LVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDE 306
Q +++ L+ ++ E D + E + +K +++ Q + +T +++ + +
Sbjct: 405 KCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQ 464
Query: 307 NFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYM 349
+ + L+E LQ++KE+L+ E LL YM
Sbjct: 465 LSESKRELTELRSALRVLQKEKEQLQ-------EEKQELLEYM 500
Score = 38.5 bits (88), Expect = 0.012
Identities = 29/123 (23%), Positives = 64/123 (52%), Gaps = 9/123 (7%)
Query: 144 EIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE--- 200
E+ + N L + LK+ K+ + + ++ +++++ L + +LE V+E
Sbjct: 386 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERT 445
Query: 201 QKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQ 260
Q ++TEL + K+ + SE+++ + +L++ L +KE E+L ++K E LE
Sbjct: 446 QNQVFKTELAREKDSSLVQLSESKR---ELTELRSALRVLQKEKEQL---QEEKQELLEY 499
Query: 261 LKK 263
++K
Sbjct: 500 MRK 502
Score = 28.9 bits (63), Expect = 9.9
Identities = 24/94 (25%), Positives = 47/94 (50%), Gaps = 16/94 (17%)
Query: 154 KENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLK 213
+E EL+ + LQK+ +Q E KQE LE ++ + +LE KV ++K W
Sbjct: 470 RELTELRSALRVLQKEKEQLQEE---KQELLEYMRKLEARLE-KVADEK--W-------- 515
Query: 214 EQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKL 247
N+ ++E+E+ + + A ++++ E +
Sbjct: 516 --NEDATTEDEEAAVGLSCPAALTDSEDESPEDM 547
>gi|219521893 coiled-coil transcriptional coactivator isoform 2
[Homo sapiens]
Length = 606
Score = 81.3 bits (199), Expect = 2e-15
Identities = 68/265 (25%), Positives = 126/265 (47%), Gaps = 43/265 (16%)
Query: 23 VIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPIDLN 82
V F +V + YIP V CHYT +P DWIGIF+V R+Y+TF+W ++P
Sbjct: 15 VNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTT 74
Query: 83 NKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTT---- 138
+ S VQF+ P+ +DE + A + DIL+V
Sbjct: 75 DGSPIHTSVQFQE---PRP--------MDELVTLEEA--------DGGSDILLVVPKATV 115
Query: 139 -QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQK-KQEELETLQS------- 189
Q +++E +Q +L + +L+ L+ + +++ L +QE E ++
Sbjct: 116 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS 175
Query: 190 ---INKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEK 246
I ++ ++ ++Q D+ +L+L++ Q +S + + +D+L+ + +E EK
Sbjct: 176 HGEITEERDILSRQQGDH-VARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK 234
Query: 247 L------VQGDQDKTE-QLEQLKKE 264
L VQ D++++E +LE LK++
Sbjct: 235 LLGQLKEVQADKEQSEAELEPLKEQ 259
Score = 46.6 bits (109), Expect = 5e-05
Identities = 45/228 (19%), Positives = 99/228 (43%), Gaps = 17/228 (7%)
Query: 128 ENEEDIL-----VVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQE 182
E E+DI V+T + E++ + K L +E ++L +Q +AEL+ +E
Sbjct: 199 ELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELEPLKE 258
Query: 183 ELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEK 242
+L Q +L +++ EL + +E + + V ++ +L+
Sbjct: 259 QLRGAQ----ELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGL 314
Query: 243 EM-EKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQ 301
+ E+ Q +++ L+ ++ E D + E + +K +++ Q + +T +++
Sbjct: 315 HLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKD 374
Query: 302 ELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYM 349
+ + + + L+E LQ++KE+L+ E LL YM
Sbjct: 375 SSLVQLSESKRELTELRSALRVLQKEKEQLQ-------EEKQELLEYM 415
Score = 45.4 bits (106), Expect = 1e-04
Identities = 33/143 (23%), Positives = 71/143 (49%), Gaps = 12/143 (8%)
Query: 175 AELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQ 234
AEL + + E+ + +L L +KE+K W E L Q + +E +K+
Sbjct: 293 AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLL---QSVEAEKDKI-------- 341
Query: 235 AQLSTQEKEMEKLVQGDQDKTEQLE-QLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNE 293
+LS + +EK VQ ++ + + + +L +E D + L+E +++ +L + +++ +
Sbjct: 342 LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEK 401
Query: 294 TTAMKKQQELMDENFDLSKRLSE 316
+++QEL++ L RL +
Sbjct: 402 EQLQEEKQELLEYMRKLEARLEK 424
Score = 38.5 bits (88), Expect = 0.012
Identities = 29/123 (23%), Positives = 64/123 (52%), Gaps = 9/123 (7%)
Query: 144 EIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE--- 200
E+ + N L + LK+ K+ + + ++ +++++ L + +LE V+E
Sbjct: 301 EVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERT 360
Query: 201 QKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQ 260
Q ++TEL + K+ + SE+++ + +L++ L +KE E+L ++K E LE
Sbjct: 361 QNQVFKTELAREKDSSLVQLSESKR---ELTELRSALRVLQKEKEQL---QEEKQELLEY 414
Query: 261 LKK 263
++K
Sbjct: 415 MRK 417
Score = 28.9 bits (63), Expect = 9.9
Identities = 24/94 (25%), Positives = 47/94 (50%), Gaps = 16/94 (17%)
Query: 154 KENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLK 213
+E EL+ + LQK+ +Q E KQE LE ++ + +LE KV ++K W
Sbjct: 385 RELTELRSALRVLQKEKEQLQEE---KQELLEYMRKLEARLE-KVADEK--W-------- 430
Query: 214 EQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKL 247
N+ ++E+E+ + + A ++++ E +
Sbjct: 431 --NEDATTEDEEAAVGLSCPAALTDSEDESPEDM 462
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 75.5 bits (184), Expect = 9e-14
Identities = 80/319 (25%), Positives = 151/319 (47%), Gaps = 53/319 (16%)
Query: 81 LNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRP-ENEEDIL----- 134
+ S+K +++F+ + K+ E+Y+ E G R + + E E ++L
Sbjct: 596 IKETSSKLSKIEFEKRQIKKELEHYK-----EKGE-RAEELENELHHLEKENELLQKKIT 649
Query: 135 -VVTTQGEVEEIEQHNKELCKENQELKDSCIS----------LQKQNSDMQAE---LQKK 180
+ T ++E +EQ N EL +EN++LK + S L+K+NS + E L++
Sbjct: 650 NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRN 709
Query: 181 QEELET-------LQSINKKLELKVKEQK--------DYWETELLQLKEQ-----NQKMS 220
E L+ LQ NK+LE + ++ K + +TE L++ Q NQ++
Sbjct: 710 VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQ 769
Query: 221 SENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQD---KTEQLEQLKKENDHLFLSLTEQRK 277
E ++ QL+++L E E + L + ++ +++LEQL+KEN L ++ K
Sbjct: 770 KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEK 829
Query: 278 DQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDL 337
D+K+LE+ ++++Q A K L + N + EN+ + + KE +
Sbjct: 830 DKKQLEKENKRLRQQ---AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE- 885
Query: 338 LKRENSRLLSYMGLDFNSL 356
L++EN L+ +D +L
Sbjct: 886 LEKENKELVKRATIDIKTL 904
Score = 70.5 bits (171), Expect = 3e-12
Identities = 50/207 (24%), Positives = 100/207 (48%), Gaps = 4/207 (1%)
Query: 140 GEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVK 199
GE + E+ ++E +E ++KD I +++ N+ +QAE Q + +L+ L++ N L+ ++
Sbjct: 1025 GEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQIL 1084
Query: 200 EQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLE 259
+ + + L+EQN + ++N K+ + L +Q ++ + +L+ + E
Sbjct: 1085 AL----QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE 1140
Query: 260 QLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEI 319
+ KE + L KD +KLE E+ + + K L + +L + E
Sbjct: 1141 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED 1200
Query: 320 ICNALQRQKERLEGENDLLKRENSRLL 346
N L +QK +LE +LK E ++L
Sbjct: 1201 RYNQLLKQKGQLEDLEKMLKVEQEKML 1227
Score = 63.9 bits (154), Expect = 3e-10
Identities = 57/230 (24%), Positives = 111/230 (48%), Gaps = 29/230 (12%)
Query: 136 VTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLE 195
++ + V++IE+ NK L + +E ++ + ++ EL+ +E+ E + + +L
Sbjct: 576 ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH 635
Query: 196 LKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKT 255
K E ELLQ K N K++ E + ++Q ++L + ++++K + ++ T
Sbjct: 636 HLEK------ENELLQKKITNLKITCEKIE---ALEQENSELERENRKLKKTLDSFKNLT 686
Query: 256 EQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQ---------NETTAMKKQQELMDE 306
QLE L+KEN L E R++ + L+ +M Q +E +KK EL+
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 307 NFDLSKRLS--------ENEIICNALQ---RQKERLEGENDLLKRENSRL 345
+F ++RL EN+ + L+ ++ ++LE E L+ EN L
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTL 796
Score = 56.2 bits (134), Expect = 6e-08
Identities = 50/235 (21%), Positives = 106/235 (45%), Gaps = 43/235 (18%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE 200
++ +E+ NK L KE K+SC+ L+ EL+K+ +EL +I+ K + ++E
Sbjct: 858 KIGNLEKENKTLSKEIGIYKESCVRLK--------ELEKENKELVKRATIDIKTLVTLRE 909
Query: 201 QKDYWETELLQLKEQNQKMSSENEKMGIRVDQL--------------------------- 233
+ + Q+ +K++ E EK+G+ ++L
Sbjct: 910 DLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSL 969
Query: 234 ---QAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMK 290
+ +++ E +E+ +Q ++L+ +KK + L +QR+D++++ Q+ +
Sbjct: 970 EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL-----KQRQDEERMVQSSPPIS 1024
Query: 291 QNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+ ++ QE E + RL E E LQ +K+ L+ + L+ +N+ L
Sbjct: 1025 GEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL 1079
Score = 53.9 bits (128), Expect = 3e-07
Identities = 56/230 (24%), Positives = 104/230 (45%), Gaps = 24/230 (10%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
E++ +++ T+ +E+ + + + EL+ + L+ + DM+ E ++++E L
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410
Query: 190 INKKLELKVKEQKDY-----WETELL----QLKEQNQKMSSE--NEKMGIRVDQLQAQLS 238
N LE+ K+ D WE E + +L E QK NE R+ +L+ +
Sbjct: 411 ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQ 470
Query: 239 TQEKEMEKL---VQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETT 295
+ K +E+L V + ++ +++KEN L K + LE + Q KQ+
Sbjct: 471 SLTKTVEELRTTVDSVEGNASKILKMEKENQRL-------SKKVEILENEIVQEKQSLQN 523
Query: 296 AMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
++LM E L K + E + +RQ + LE EN+ L + S L
Sbjct: 524 CQNLSKDLMKEKAQLEKTI---ETLRENSERQIKILEQENEHLNQTVSSL 570
Score = 45.4 bits (106), Expect = 1e-04
Identities = 52/211 (24%), Positives = 97/211 (45%), Gaps = 38/211 (18%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE 200
+ E +E + L ENQ L+ + + K+ +++ELQ + E +TLQ ++L++ K
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR 809
Query: 201 QKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQ 260
L QL+++N+ + E QL+ EKE ++L Q + K LE+
Sbjct: 810 --------LEQLEKENKSLEQE-------TSQLEKDKKQLEKENKRLRQQAEIKDTTLEE 854
Query: 261 -------LKKENDHL----------FLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQEL 303
L+KEN L + L E K+ K+L V++ + T + +++L
Sbjct: 855 NNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKEL---VKRATIDIKTLVTLREDL 911
Query: 304 MDENFDLSKRLSENEIICNALQR---QKERL 331
+ E + ++ E + + L++ KERL
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERL 942
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/221 (21%), Positives = 103/221 (46%), Gaps = 21/221 (9%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQA-------------ELQKKQEELETL 187
E+E++E K L +EN L S + ++ A E+ + +E L +
Sbjct: 280 ELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDI 339
Query: 188 QSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKM-GIRVDQLQAQLSTQEKEMEK 246
+ ++E ++ + ET+ + L++Q + + ++K+ + + LQ + + EME+
Sbjct: 340 EFYKARVEELKEDNQVLLETKTM-LEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER 398
Query: 247 LVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDE 306
D D+ +++E+L +EN L ++ + + L +EQ+ + + Q+ L E
Sbjct: 399 ----DMDR-KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHE 453
Query: 307 NFDL-SKRLSENEIICNALQRQKERLEGENDLLKRENSRLL 346
+L S RL + E+ +L + E L D ++ S++L
Sbjct: 454 VNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL 494
Score = 42.7 bits (99), Expect = 7e-04
Identities = 52/203 (25%), Positives = 96/203 (47%), Gaps = 27/203 (13%)
Query: 145 IEQHNKELCKENQELKDSCISLQKQN---SDMQAELQKKQEEL-------ETLQSINKKL 194
++ +K L E+++L+D L KQ D++ L+ +QE++ ET+ + KKL
Sbjct: 1184 LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKL 1243
Query: 195 -----ELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQ 249
L + ETE+LQ +N K N K + +L+A+ S +++ ++L
Sbjct: 1244 CGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSK--LEQTRLEAEFSKLKEQYQQLDI 1301
Query: 250 GDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFD 309
Q E L + +L + +++ L+Q M QN T + +Q + F
Sbjct: 1302 TSTKLNNQCELLSQLKGNL------EEENRHLLDQIQTLMLQNRT--LLEQNMESKDLFH 1353
Query: 310 LSKRLSENEIICNALQRQKERLE 332
+ +R +++ N L+RQKE+LE
Sbjct: 1354 VEQRQYIDKL--NELRRQKEKLE 1374
Score = 42.0 bits (97), Expect = 0.001
Identities = 48/227 (21%), Positives = 102/227 (44%), Gaps = 31/227 (13%)
Query: 135 VVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQK-----------KQEE 183
+ + +EE +N++L +E + +K + +L KQ D + +Q ++E
Sbjct: 976 IAALEARLEESTNYNQQLRQELKTVKKNYEAL-KQRQDEERMVQSSPPISGEDNKWERES 1034
Query: 184 LETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKE 243
ET + + LKVK++ L++++ N + +E + + ++ QL+ Q + + +
Sbjct: 1035 QETTREL-----LKVKDR-------LIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ 1082
Query: 244 MEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQEL 303
+ L + EQ L+ +N L Q ++ Q+ M QN ++ Q L
Sbjct: 1083 ILALQRQTVSLQEQNTTLQTQNAKL------QVENSTLNSQSTSLMNQNAQLLIQ-QSSL 1135
Query: 304 MDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMG 350
+EN + K + + + ++L + E+LE ++ E L+S G
Sbjct: 1136 ENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHG 1182
Score = 42.0 bits (97), Expect = 0.001
Identities = 39/164 (23%), Positives = 75/164 (45%), Gaps = 22/164 (13%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQK 202
E + K+LC EN L + L K+ +Q + + L++L + N KLE +
Sbjct: 1234 ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTD----HKNLKSLLN-NSKLE------Q 1282
Query: 203 DYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLK 262
E E +LKEQ Q++ + K+ + + L E+E L+ +Q++ L
Sbjct: 1283 TRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLL-------DQIQTLM 1335
Query: 263 KENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDE 306
+N +L EQ + K L ++ ++ +++Q+E ++E
Sbjct: 1336 LQN----RTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEE 1375
Score = 40.0 bits (92), Expect = 0.004
Identities = 43/243 (17%), Positives = 99/243 (40%), Gaps = 24/243 (9%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ E ++++ ++L + +L + C L + +++ E + ++++TL N+ L +
Sbjct: 1286 EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1345
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRV-DQLQAQLSTQEK--------EMEKLVQ 249
E KD + E Q ++ ++ + EK+ ++ DQ + + + +M KL++
Sbjct: 1346 MESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIK 1405
Query: 250 GDQD------KTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQEL 303
+D K+ L + ++ FL L Q Q ++ +T KK +
Sbjct: 1406 SKKDINRERQKSLTLTPTRSDSSEGFLQLPHQ-DSQDSSSVGSNSLEDGQTLGTKKSSTM 1464
Query: 304 MDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQVPTS 363
D L ++ ++ E LE +D+ + + L M ++ + S
Sbjct: 1465 ND--------LVQSMVLAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNS 1516
Query: 364 DEG 366
G
Sbjct: 1517 SAG 1519
Score = 33.1 bits (74), Expect = 0.52
Identities = 39/183 (21%), Positives = 81/183 (44%), Gaps = 20/183 (10%)
Query: 181 QEELETLQSINKKLELK--VKEQKDYWETELLQLKEQNQKM--------------SSENE 224
QE++E L N L LK + E+ ++ ET +++L E+ + S
Sbjct: 183 QEDIEPLLK-NMALHLKRLIDERDEHSET-IIELSEERDGLHFLPHASSSAQSPCGSPGM 240
Query: 225 KMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKL-- 282
K L +L+ + ++ +L Q ++KTEQL K+E + + + L +++ L
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 283 EQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKREN 342
+ +M ++E A++++ +D+ R E + + E L+ +N +L
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
Query: 343 SRL 345
+ L
Sbjct: 361 TML 363
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 75.5 bits (184), Expect = 9e-14
Identities = 80/319 (25%), Positives = 151/319 (47%), Gaps = 53/319 (16%)
Query: 81 LNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRP-ENEEDIL----- 134
+ S+K +++F+ + K+ E+Y+ E G R + + E E ++L
Sbjct: 596 IKETSSKLSKIEFEKRQIKKELEHYK-----EKGE-RAEELENELHHLEKENELLQKKIT 649
Query: 135 -VVTTQGEVEEIEQHNKELCKENQELKDSCIS----------LQKQNSDMQAE---LQKK 180
+ T ++E +EQ N EL +EN++LK + S L+K+NS + E L++
Sbjct: 650 NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRN 709
Query: 181 QEELET-------LQSINKKLELKVKEQK--------DYWETELLQLKEQ-----NQKMS 220
E L+ LQ NK+LE + ++ K + +TE L++ Q NQ++
Sbjct: 710 VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQ 769
Query: 221 SENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQD---KTEQLEQLKKENDHLFLSLTEQRK 277
E ++ QL+++L E E + L + ++ +++LEQL+KEN L ++ K
Sbjct: 770 KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEK 829
Query: 278 DQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDL 337
D+K+LE+ ++++Q A K L + N + EN+ + + KE +
Sbjct: 830 DKKQLEKENKRLRQQ---AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE- 885
Query: 338 LKRENSRLLSYMGLDFNSL 356
L++EN L+ +D +L
Sbjct: 886 LEKENKELVKRATIDIKTL 904
Score = 70.5 bits (171), Expect = 3e-12
Identities = 50/207 (24%), Positives = 100/207 (48%), Gaps = 4/207 (1%)
Query: 140 GEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVK 199
GE + E+ ++E +E ++KD I +++ N+ +QAE Q + +L+ L++ N L+ ++
Sbjct: 1024 GEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQIL 1083
Query: 200 EQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLE 259
+ + + L+EQN + ++N K+ + L +Q ++ + +L+ + E
Sbjct: 1084 AL----QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE 1139
Query: 260 QLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEI 319
+ KE + L KD +KLE E+ + + K L + +L + E
Sbjct: 1140 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED 1199
Query: 320 ICNALQRQKERLEGENDLLKRENSRLL 346
N L +QK +LE +LK E ++L
Sbjct: 1200 RYNQLLKQKGQLEDLEKMLKVEQEKML 1226
Score = 63.9 bits (154), Expect = 3e-10
Identities = 57/230 (24%), Positives = 111/230 (48%), Gaps = 29/230 (12%)
Query: 136 VTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLE 195
++ + V++IE+ NK L + +E ++ + ++ EL+ +E+ E + + +L
Sbjct: 576 ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH 635
Query: 196 LKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKT 255
K E ELLQ K N K++ E + ++Q ++L + ++++K + ++ T
Sbjct: 636 HLEK------ENELLQKKITNLKITCEKIE---ALEQENSELERENRKLKKTLDSFKNLT 686
Query: 256 EQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQ---------NETTAMKKQQELMDE 306
QLE L+KEN L E R++ + L+ +M Q +E +KK EL+
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 307 NFDLSKRLS--------ENEIICNALQ---RQKERLEGENDLLKRENSRL 345
+F ++RL EN+ + L+ ++ ++LE E L+ EN L
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTL 796
Score = 56.6 bits (135), Expect = 4e-08
Identities = 50/234 (21%), Positives = 106/234 (45%), Gaps = 42/234 (17%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE 200
++ +E+ NK L KE K+SC+ L+ EL+K+ +EL +I+ K + ++E
Sbjct: 858 KIGNLEKENKTLSKEIGIYKESCVRLK--------ELEKENKELVKRATIDIKTLVTLRE 909
Query: 201 QKDYWETELLQLKEQNQKMSSENEKMGIRVDQL--------------------------- 233
+ + Q+ +K++ E EK+G+ ++L
Sbjct: 910 DLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLE 969
Query: 234 --QAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQ 291
+ +++ E +E+ +Q ++L+ +KK + L +QR+D++++ Q+ +
Sbjct: 970 IKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL-----KQRQDEERMVQSSPPISG 1024
Query: 292 NETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+ ++ QE E + RL E E LQ +K+ L+ + L+ +N+ L
Sbjct: 1025 EDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL 1078
Score = 53.9 bits (128), Expect = 3e-07
Identities = 56/230 (24%), Positives = 104/230 (45%), Gaps = 24/230 (10%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
E++ +++ T+ +E+ + + + EL+ + L+ + DM+ E ++++E L
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410
Query: 190 INKKLELKVKEQKDY-----WETELL----QLKEQNQKMSSE--NEKMGIRVDQLQAQLS 238
N LE+ K+ D WE E + +L E QK NE R+ +L+ +
Sbjct: 411 ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQ 470
Query: 239 TQEKEMEKL---VQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETT 295
+ K +E+L V + ++ +++KEN L K + LE + Q KQ+
Sbjct: 471 SLTKTVEELRTTVDSVEGNASKILKMEKENQRL-------SKKVEILENEIVQEKQSLQN 523
Query: 296 AMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
++LM E L K + E + +RQ + LE EN+ L + S L
Sbjct: 524 CQNLSKDLMKEKAQLEKTI---ETLRENSERQIKILEQENEHLNQTVSSL 570
Score = 45.8 bits (107), Expect = 8e-05
Identities = 57/231 (24%), Positives = 105/231 (45%), Gaps = 42/231 (18%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE 200
+ E +E + L ENQ L+ + + K+ +++ELQ + E +TLQ ++L++ K
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR 809
Query: 201 QKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQ 260
L QL+++N+ + E QL+ EKE ++L Q + K LE+
Sbjct: 810 --------LEQLEKENKSLEQE-------TSQLEKDKKQLEKENKRLRQQAEIKDTTLEE 854
Query: 261 -------LKKENDHL----------FLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQEL 303
L+KEN L + L E K+ K+L V++ + T + +++L
Sbjct: 855 NNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKEL---VKRATIDIKTLVTLREDL 911
Query: 304 MDENFDLSKRLSENEIICNALQR---QKERL----EGENDLLKRENSRLLS 347
+ E + ++ E + + L++ KERL + +D K S+L S
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLES 962
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/221 (21%), Positives = 103/221 (46%), Gaps = 21/221 (9%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQA-------------ELQKKQEELETL 187
E+E++E K L +EN L S + ++ A E+ + +E L +
Sbjct: 280 ELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDI 339
Query: 188 QSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKM-GIRVDQLQAQLSTQEKEMEK 246
+ ++E ++ + ET+ + L++Q + + ++K+ + + LQ + + EME+
Sbjct: 340 EFYKARVEELKEDNQVLLETKTM-LEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER 398
Query: 247 LVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDE 306
D D+ +++E+L +EN L ++ + + L +EQ+ + + Q+ L E
Sbjct: 399 ----DMDR-KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHE 453
Query: 307 NFDL-SKRLSENEIICNALQRQKERLEGENDLLKRENSRLL 346
+L S RL + E+ +L + E L D ++ S++L
Sbjct: 454 VNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL 494
Score = 42.7 bits (99), Expect = 7e-04
Identities = 52/203 (25%), Positives = 96/203 (47%), Gaps = 27/203 (13%)
Query: 145 IEQHNKELCKENQELKDSCISLQKQN---SDMQAELQKKQEEL-------ETLQSINKKL 194
++ +K L E+++L+D L KQ D++ L+ +QE++ ET+ + KKL
Sbjct: 1183 LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKL 1242
Query: 195 -----ELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQ 249
L + ETE+LQ +N K N K + +L+A+ S +++ ++L
Sbjct: 1243 CGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSK--LEQTRLEAEFSKLKEQYQQLDI 1300
Query: 250 GDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFD 309
Q E L + +L + +++ L+Q M QN T + +Q + F
Sbjct: 1301 TSTKLNNQCELLSQLKGNL------EEENRHLLDQIQTLMLQNRT--LLEQNMESKDLFH 1352
Query: 310 LSKRLSENEIICNALQRQKERLE 332
+ +R +++ N L+RQKE+LE
Sbjct: 1353 VEQRQYIDKL--NELRRQKEKLE 1373
Score = 42.0 bits (97), Expect = 0.001
Identities = 48/227 (21%), Positives = 102/227 (44%), Gaps = 31/227 (13%)
Query: 135 VVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQK-----------KQEE 183
+ + +EE +N++L +E + +K + +L KQ D + +Q ++E
Sbjct: 975 IAALEARLEESTNYNQQLRQELKTVKKNYEAL-KQRQDEERMVQSSPPISGEDNKWERES 1033
Query: 184 LETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKE 243
ET + + LKVK++ L++++ N + +E + + ++ QL+ Q + + +
Sbjct: 1034 QETTREL-----LKVKDR-------LIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ 1081
Query: 244 MEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQEL 303
+ L + EQ L+ +N L Q ++ Q+ M QN ++ Q L
Sbjct: 1082 ILALQRQTVSLQEQNTTLQTQNAKL------QVENSTLNSQSTSLMNQNAQLLIQ-QSSL 1134
Query: 304 MDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMG 350
+EN + K + + + ++L + E+LE ++ E L+S G
Sbjct: 1135 ENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHG 1181
Score = 42.0 bits (97), Expect = 0.001
Identities = 39/164 (23%), Positives = 75/164 (45%), Gaps = 22/164 (13%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQK 202
E + K+LC EN L + L K+ +Q + + L++L + N KLE +
Sbjct: 1233 ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTD----HKNLKSLLN-NSKLE------Q 1281
Query: 203 DYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLK 262
E E +LKEQ Q++ + K+ + + L E+E L+ +Q++ L
Sbjct: 1282 TRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLL-------DQIQTLM 1334
Query: 263 KENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDE 306
+N +L EQ + K L ++ ++ +++Q+E ++E
Sbjct: 1335 LQN----RTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEE 1374
Score = 33.9 bits (76), Expect = 0.31
Identities = 33/176 (18%), Positives = 77/176 (43%), Gaps = 16/176 (9%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ E ++++ ++L + +L + C L + +++ E + ++++TL N+ L +
Sbjct: 1285 EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1344
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRV-DQLQAQLSTQEK--------EMEKLVQ 249
E KD + E Q ++ ++ + EK+ ++ DQ + + + +M KL++
Sbjct: 1345 MESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIK 1404
Query: 250 GDQD------KTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKK 299
+D K+ L + ++ FL L Q Q ++ +T KK
Sbjct: 1405 SKKDINRERQKSLTLTPTRSDSSEGFLQLPHQ-DSQDSSSVGSNSLEDGQTLGTKK 1459
Score = 33.1 bits (74), Expect = 0.52
Identities = 39/183 (21%), Positives = 81/183 (44%), Gaps = 20/183 (10%)
Query: 181 QEELETLQSINKKLELK--VKEQKDYWETELLQLKEQNQKM--------------SSENE 224
QE++E L N L LK + E+ ++ ET +++L E+ + S
Sbjct: 183 QEDIEPLLK-NMALHLKRLIDERDEHSET-IIELSEERDGLHFLPHASSSAQSPCGSPGM 240
Query: 225 KMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKL-- 282
K L +L+ + ++ +L Q ++KTEQL K+E + + + L +++ L
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 283 EQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKREN 342
+ +M ++E A++++ +D+ R E + + E L+ +N +L
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
Query: 343 SRL 345
+ L
Sbjct: 361 TML 363
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 72.0 bits (175), Expect = 1e-12
Identities = 44/207 (21%), Positives = 110/207 (53%), Gaps = 11/207 (5%)
Query: 128 ENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETL 187
E EE + Q + E++++ +++ K+ +++++ +++Q M + ++ ++E +T
Sbjct: 238 EQEEQV-----QKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTG 292
Query: 188 QSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKL 247
+ E +++EQ++ + Q++EQ ++M + E+MG + +Q+ Q ++ E++
Sbjct: 293 EQ-----EEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQM 347
Query: 248 VQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDEN 307
+ ++ EQ EQ++K+ + + + RK ++++ + EQM++ E M +Q+E M E
Sbjct: 348 WKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQE-EQMGEQKEQMGEQ 406
Query: 308 FDLSKRLSENEIICNALQRQKERLEGE 334
+ + E R++E GE
Sbjct: 407 KEQMREQEEQMGEQKEQMRKQEEHMGE 433
Score = 68.6 bits (166), Expect = 1e-11
Identities = 40/216 (18%), Positives = 117/216 (54%), Gaps = 1/216 (0%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
E++ V +G+V E E +E + E + ++Q + + ++QK++E++ +
Sbjct: 168 EQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEE 227
Query: 190 INKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQ 249
+K E ++ EQ++ + + Q+++Q ++M + E+M + +Q++ Q K+ E+ Q
Sbjct: 228 QMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQ 287
Query: 250 GDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFD 309
+Q EQ EQ++++ + + + R+ ++++ + EQM + E ++++++ ++
Sbjct: 288 EEQ-TGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQ 346
Query: 310 LSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+ K+ + +Q+Q+E++ + + ++++ ++
Sbjct: 347 MWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQM 382
Score = 68.2 bits (165), Expect = 1e-11
Identities = 42/218 (19%), Positives = 115/218 (52%), Gaps = 5/218 (2%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
E++ V +G+V E E +E + +E + + Q + + ++++++ ++ +
Sbjct: 112 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 171
Query: 190 INKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQ 249
++ E +V+EQ+ + Q+ EQ +M + E+MG + +Q+Q Q ++ E++ +
Sbjct: 172 QVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRK 231
Query: 250 GDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAM--KKQQELMDEN 307
++ EQ EQ++K+ + + + RK ++++ + EQM++ E + K+Q E ++
Sbjct: 232 QEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQT 291
Query: 308 FDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+ +++ E E ++ Q+E++ + + ++ + ++
Sbjct: 292 GEQEEQMREQE---EQMREQEEQMREQEEQMREQEEQM 326
Score = 68.2 bits (165), Expect = 1e-11
Identities = 37/216 (17%), Positives = 115/216 (53%), Gaps = 9/216 (4%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAE---LQKKQEELETLQSINKKLE 195
Q + E++ + +++ K+ +++ + +QKQ +Q + ++K++E++ + ++ E
Sbjct: 216 QKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQE 275
Query: 196 LKVKEQKDYWETELL------QLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQ 249
++ +QK+ E E Q++EQ ++M + E+M + +Q++ Q K+ E++ +
Sbjct: 276 EQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWE 335
Query: 250 GDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFD 309
+ EQ EQ+ K+ + + + +K ++++ + EQM++ E K+++++ +
Sbjct: 336 QKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQ 395
Query: 310 LSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+ ++ + ++ Q+E++ + + ++++ +
Sbjct: 396 MGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHM 431
Score = 61.2 bits (147), Expect = 2e-09
Identities = 41/219 (18%), Positives = 121/219 (55%), Gaps = 23/219 (10%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDM---QAELQKKQEELETLQSINKKLELKVK 199
E++ + +++ K+ +++ + ++KQ M + ++QK++E+++ + +K E +++
Sbjct: 206 EQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMR 265
Query: 200 EQKDYW---ETELLQLKEQNQK---MSSENEKMGIRVDQL---QAQLSTQEKEM----EK 246
EQ++ E ++L+ KEQ ++ + E+M + +Q+ + Q+ QE++M E+
Sbjct: 266 EQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQ 325
Query: 247 LVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDE 306
+ + ++ EQ EQ+ ++ + ++ + + ++++++ EQ+++ E M+KQ+E M +
Sbjct: 326 MGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQE-EQMRKQEEQMRK 384
Query: 307 NFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+ ++ E + QKE++ + + ++ + ++
Sbjct: 385 QEEQMRKQEEQ------MGEQKEQMGEQKEQMREQEEQM 417
Score = 54.3 bits (129), Expect = 2e-07
Identities = 46/218 (21%), Positives = 106/218 (48%), Gaps = 21/218 (9%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
E++ V +G+V E E +E + +E + + Q + + ++++++ ++ +
Sbjct: 98 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 157
Query: 190 INKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQ 249
++ E +V+EQ+ + Q++EQ ++ + +MG + + Q+ QE++M
Sbjct: 158 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMG----EQEGQMGEQEEQMG---- 209
Query: 250 GDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMK------QNETTAMKKQQEL 303
EQ EQ++K+ + + + RK ++++ + EQ++ Q + M+KQ+E
Sbjct: 210 ------EQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQ 263
Query: 304 MDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
M E + R E +++ Q ++E GE + RE
Sbjct: 264 MREQ-EEQMREQEEQMLKQKEQTEQEEQTGEQEEQMRE 300
Score = 47.8 bits (112), Expect = 2e-05
Identities = 39/216 (18%), Positives = 103/216 (47%), Gaps = 7/216 (3%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
E++ V +G+V E E +E + +E + + Q + + ++++++ ++ +
Sbjct: 63 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 122
Query: 190 INKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQ 249
++ E +V+EQ+ + Q++EQ ++ + ++ + Q++ Q Q +E E V+
Sbjct: 123 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ-EGQVREQEGQVR 181
Query: 250 GDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFD 309
+ + + E E + EQ +Q++ Q E+ + M+KQ+E M E +
Sbjct: 182 EQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEE 241
Query: 310 LSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
++ E +Q+Q+E++ + + ++ + ++
Sbjct: 242 QVQKQEEQ------VQKQEEQMRKQEEQMREQEEQM 271
Score = 44.7 bits (104), Expect = 2e-04
Identities = 30/217 (13%), Positives = 109/217 (50%), Gaps = 7/217 (3%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
E++ V +G+V E E +E + +E + + Q + + ++++++ ++ +
Sbjct: 70 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 129
Query: 190 INKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQ 249
++ E +V+EQ+ + Q++EQ ++ + ++ + Q++ Q ++ ++ +
Sbjct: 130 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 189
Query: 250 GDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFD 309
+ EQ Q+ ++ + + + +K ++++ + EQM++ E ++++++ +
Sbjct: 190 QEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQ 249
Query: 310 LSKRLSENEIICNALQRQKERLEGENDLLKRENSRLL 346
+ K+ + +++Q+E++ + + ++ + ++L
Sbjct: 250 VQKQEEQ-------MRKQEEQMREQEEQMREQEEQML 279
Score = 43.9 bits (102), Expect = 3e-04
Identities = 37/224 (16%), Positives = 113/224 (50%), Gaps = 9/224 (4%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
E D + + +G+V E E +E + +E + + Q + + ++++++ ++ +
Sbjct: 42 ETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 101
Query: 190 INKKLELKVKEQKDYWETELLQLKEQNQKMSSE----NEKMGIRVDQLQAQLSTQE---K 242
++ E +V+EQ+ + Q++EQ ++ + E+ G +V + + Q+ QE +
Sbjct: 102 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG-QVREQEGQVREQEGQVR 160
Query: 243 EMEKLVQGDQDKT-EQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQ 301
E E V+ + + EQ Q++++ + + + + ++ + EQM + E K+++
Sbjct: 161 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEE 220
Query: 302 ELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
++ ++ + K+ + +Q+Q+E+++ + + ++++ ++
Sbjct: 221 QMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQM 264
Score = 40.8 bits (94), Expect = 0.003
Identities = 31/159 (19%), Positives = 85/159 (53%), Gaps = 3/159 (1%)
Query: 149 NKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETE 208
N+EL ++N EL++ ++ + S++Q +++ + +LET I E +V+EQ+ +
Sbjct: 6 NEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLET-DKIPLPQEGQVREQEGQVREQ 64
Query: 209 LLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKT-EQLEQLKKENDH 267
Q++EQ ++ + ++ + Q++ Q Q +E E V+ + + EQ Q++++
Sbjct: 65 EGQVREQEGQVREQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVREQEGQVREQEGQ 123
Query: 268 LFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDE 306
+ + R+ + ++ + Q+++ E +++ ++ ++
Sbjct: 124 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 162
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 68.9 bits (167), Expect = 9e-12
Identities = 41/212 (19%), Positives = 115/212 (54%), Gaps = 12/212 (5%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKL---ELKVK 199
E+I++ +++C++ ++++ + +Q M + +K +E+ + + +K+ E K++
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIR 363
Query: 200 EQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLE 259
EQ++ + +++EQ++K+ + E+M + ++++ Q +EK EK+ + ++ EQ E
Sbjct: 364 EQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQ---EEKRQEKMWRQEKKMREQDE 420
Query: 260 QLKKENDHLF------LSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKR 313
+++++ + ++ L E +DQ++ + VE+ Q E M++Q+E + + +
Sbjct: 421 KIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQE 480
Query: 314 LSENEIICNALQRQKERLEGENDLLKRENSRL 345
E L +Q+E++ + + + R+ ++
Sbjct: 481 QEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKM 512
Score = 63.9 bits (154), Expect = 3e-10
Identities = 43/213 (20%), Positives = 114/213 (53%), Gaps = 18/213 (8%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQ- 201
E+I + +++ ++ +++++ +Q+Q +M + +K +E+ E Q + E K++EQ
Sbjct: 360 EKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQD 419
Query: 202 -------KDYW--ETELLQLKE----QNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLV 248
++ W E ++ +L+E Q +K+ EKM +++Q Q +++ EK +
Sbjct: 420 EKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEK-I 478
Query: 249 QGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENF 308
Q ++KT + E+L K+ + ++ + + ++K+ + E+M++ E ++++++ ++
Sbjct: 479 QEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEV 538
Query: 309 DL---SKRLSENEIICNALQRQKERLEGENDLL 338
L +++ E E+ L+ + +L + +LL
Sbjct: 539 RLWQQEEKMQEQEVRLQELEERLGKLGQKAELL 571
Score = 58.5 bits (140), Expect = 1e-08
Identities = 37/214 (17%), Positives = 115/214 (53%), Gaps = 23/214 (10%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKL---ELKVK 199
E+I + ++ ++ +++++ +++Q M + +K +E+ E +Q +++ E K++
Sbjct: 339 EKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIR 398
Query: 200 EQKD-----YWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDK 254
EQ++ W E +++EQ++K+ + E+M + +++ +E+E+++Q ++K
Sbjct: 399 EQEEKRQEKMWRQEK-KMREQDEKIREQEEEMWRQEEKI--------RELEEMMQDQEEK 449
Query: 255 TEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDL---S 311
++E+ +E + E+ + Q++ Q E+ + +K+++++ ++ +
Sbjct: 450 LREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQE 509
Query: 312 KRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+++ E E +Q Q+E+++ + + ++ + RL
Sbjct: 510 EKMWEQE---EKMQEQEEKMQRQEEKMREQEVRL 540
Score = 58.2 bits (139), Expect = 2e-08
Identities = 36/197 (18%), Positives = 110/197 (55%), Gaps = 9/197 (4%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
Q + EE+ + +++ ++ ++ ++ +K+ + ++++++EE+ + ++LE +
Sbjct: 384 QEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMM 443
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEK--EMEKLVQGDQDKTE 256
++Q++ +++E+ +KM + EK+ + +++Q Q +EK EKL++ ++ E
Sbjct: 444 QDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQ---EEKTWRQEKLLKQEEKIWE 500
Query: 257 QLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSE 316
Q E++ ++ + ++ + ++ ++K+++ E+M++ E ++++++ ++ RL E
Sbjct: 501 QEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEV----RLQE 556
Query: 317 NEIICNALQRQKERLEG 333
E L ++ E L G
Sbjct: 557 LEERLGKLGQKAELLGG 573
Score = 55.8 bits (133), Expect = 8e-08
Identities = 47/265 (17%), Positives = 129/265 (48%), Gaps = 27/265 (10%)
Query: 103 EYYQFCYVDEDGVVRGASIPFQFR-PENEEDILVVTTQGEVEEIEQHNKELCKENQELKD 161
E Y+ DE+ + A + + R E+E+ + + + ++E+ +L Q+L+
Sbjct: 205 ELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLER--AQLLLPQQQLQV 262
Query: 162 SCISLQKQNSDMQAELQKKQEELETLQSINKKLE---------------------LKVKE 200
L K+ + A+LQ + EE E +N++ E LK++E
Sbjct: 263 EADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIRE 322
Query: 201 QKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQ 260
Q++ + ++ EQ +K+ + +KM + ++++ Q ++ EK+ + ++ EQ E+
Sbjct: 323 QEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEK 382
Query: 261 LKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEII 320
++++ + ++ ++ K +++ E+ E+M + E ++ +++ ++ ++ ++ + +
Sbjct: 383 IQEQEEEMW---RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIREL 439
Query: 321 CNALQRQKERLEGENDLLKRENSRL 345
+Q Q+E+L + ++ E ++
Sbjct: 440 EEMMQDQEEKLREVEEKMQEEEEKM 464
Score = 46.2 bits (108), Expect = 6e-05
Identities = 43/170 (25%), Positives = 89/170 (52%), Gaps = 8/170 (4%)
Query: 141 EVEEIEQHNKELCKENQE-LKDSCISLQKQNSDMQAELQKKQEELETLQSINK--KLELK 197
E+EE+ Q +E +E +E +++ +Q+Q +Q + +K QE+ E K K E K
Sbjct: 438 ELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEK 497
Query: 198 VKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQ---LSTQEKEMEKLVQGDQDK 254
+ EQ++ + ++ EQ +KM + EKM + ++++ Q L QE++M++ Q+
Sbjct: 498 IWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQEL 557
Query: 255 TEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQ--MKQNETTAMKKQQE 302
E+L +L ++ + L + E + + Q +K E ++++QQ+
Sbjct: 558 EERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQD 607
Score = 43.5 bits (101), Expect = 4e-04
Identities = 54/292 (18%), Positives = 136/292 (46%), Gaps = 44/292 (15%)
Query: 83 NKSAKQQEVQFKAYYLPK-----DDEYYQFCYVD---EDGVVRGASIPFQFRPENEEDIL 134
NK +Q +V+ K + P+ D++++Q ++ E+ RG R + ++D+
Sbjct: 37 NKLEQQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTK-----RWDEDDDLE 91
Query: 135 VVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSD-MQAELQKKQEEL-ETLQSINK 192
+ +E + +++ ++D+ +S K+NSD +++ +K+QE++ E + K
Sbjct: 92 ESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNEKNYTFRK 151
Query: 193 KLELKVKEQKDYWETELLQLKEQNQKMSSENE------------KMGIRVDQLQAQLSTQ 240
++ +K W L+L E + EN +MG +++L +
Sbjct: 152 RVVIKKP-----W----LRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAP 202
Query: 241 EKEM-------EKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNE 293
E+ E+L + + + E+L ++ E + L++ + ++ ++ + + Q +Q +
Sbjct: 203 SLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQ-QQLQ 261
Query: 294 TTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
A + +EL + L ++ ENE+ Q+Q+E++ + + ++ + ++
Sbjct: 262 VEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKM 313
Score = 43.5 bits (101), Expect = 4e-04
Identities = 36/170 (21%), Positives = 88/170 (51%), Gaps = 17/170 (10%)
Query: 124 QFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEE 183
Q + E+D + + E+ E+ +EL + Q+ ++ ++++ + + ++Q+++E+
Sbjct: 411 QEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEK 470
Query: 184 LETLQSINKKLELKVKEQKD-YWETELL-----QLKEQNQKMSSENEKMGIRVDQLQAQL 237
++ + E K++EQ++ W E L ++ EQ +KM + EKM + +++Q Q
Sbjct: 471 IQ-------RQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQE 523
Query: 238 STQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVE 287
+++ EK+ + + +Q E+++++ + L E + KL Q E
Sbjct: 524 EKMQRQEEKMREQEVRLWQQEEKMQEQE----VRLQELEERLGKLGQKAE 569
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 68.9 bits (167), Expect = 9e-12
Identities = 41/212 (19%), Positives = 115/212 (54%), Gaps = 12/212 (5%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKL---ELKVK 199
E+I++ +++C++ ++++ + +Q M + +K +E+ + + +K+ E K++
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIR 363
Query: 200 EQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLE 259
EQ++ + +++EQ++K+ + E+M + ++++ Q +EK EK+ + ++ EQ E
Sbjct: 364 EQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQ---EEKRQEKMWRQEKKMREQDE 420
Query: 260 QLKKENDHLF------LSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKR 313
+++++ + ++ L E +DQ++ + VE+ Q E M++Q+E + + +
Sbjct: 421 KIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQE 480
Query: 314 LSENEIICNALQRQKERLEGENDLLKRENSRL 345
E L +Q+E++ + + + R+ ++
Sbjct: 481 QEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKM 512
Score = 63.9 bits (154), Expect = 3e-10
Identities = 43/213 (20%), Positives = 114/213 (53%), Gaps = 18/213 (8%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQ- 201
E+I + +++ ++ +++++ +Q+Q +M + +K +E+ E Q + E K++EQ
Sbjct: 360 EKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQD 419
Query: 202 -------KDYW--ETELLQLKE----QNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLV 248
++ W E ++ +L+E Q +K+ EKM +++Q Q +++ EK +
Sbjct: 420 EKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEK-I 478
Query: 249 QGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENF 308
Q ++KT + E+L K+ + ++ + + ++K+ + E+M++ E ++++++ ++
Sbjct: 479 QEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEV 538
Query: 309 DL---SKRLSENEIICNALQRQKERLEGENDLL 338
L +++ E E+ L+ + +L + +LL
Sbjct: 539 RLWQQEEKMQEQEVRLQELEERLGKLGQKAELL 571
Score = 58.5 bits (140), Expect = 1e-08
Identities = 37/214 (17%), Positives = 115/214 (53%), Gaps = 23/214 (10%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKL---ELKVK 199
E+I + ++ ++ +++++ +++Q M + +K +E+ E +Q +++ E K++
Sbjct: 339 EKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIR 398
Query: 200 EQKD-----YWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDK 254
EQ++ W E +++EQ++K+ + E+M + +++ +E+E+++Q ++K
Sbjct: 399 EQEEKRQEKMWRQEK-KMREQDEKIREQEEEMWRQEEKI--------RELEEMMQDQEEK 449
Query: 255 TEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDL---S 311
++E+ +E + E+ + Q++ Q E+ + +K+++++ ++ +
Sbjct: 450 LREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQE 509
Query: 312 KRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+++ E E +Q Q+E+++ + + ++ + RL
Sbjct: 510 EKMWEQE---EKMQEQEEKMQRQEEKMREQEVRL 540
Score = 58.2 bits (139), Expect = 2e-08
Identities = 36/197 (18%), Positives = 110/197 (55%), Gaps = 9/197 (4%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
Q + EE+ + +++ ++ ++ ++ +K+ + ++++++EE+ + ++LE +
Sbjct: 384 QEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMM 443
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEK--EMEKLVQGDQDKTE 256
++Q++ +++E+ +KM + EK+ + +++Q Q +EK EKL++ ++ E
Sbjct: 444 QDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQ---EEKTWRQEKLLKQEEKIWE 500
Query: 257 QLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSE 316
Q E++ ++ + ++ + ++ ++K+++ E+M++ E ++++++ ++ RL E
Sbjct: 501 QEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEV----RLQE 556
Query: 317 NEIICNALQRQKERLEG 333
E L ++ E L G
Sbjct: 557 LEERLGKLGQKAELLGG 573
Score = 55.8 bits (133), Expect = 8e-08
Identities = 47/265 (17%), Positives = 129/265 (48%), Gaps = 27/265 (10%)
Query: 103 EYYQFCYVDEDGVVRGASIPFQFR-PENEEDILVVTTQGEVEEIEQHNKELCKENQELKD 161
E Y+ DE+ + A + + R E+E+ + + + ++E+ +L Q+L+
Sbjct: 205 ELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLER--AQLLLPQQQLQV 262
Query: 162 SCISLQKQNSDMQAELQKKQEELETLQSINKKLE---------------------LKVKE 200
L K+ + A+LQ + EE E +N++ E LK++E
Sbjct: 263 EADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIRE 322
Query: 201 QKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQ 260
Q++ + ++ EQ +K+ + +KM + ++++ Q ++ EK+ + ++ EQ E+
Sbjct: 323 QEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEK 382
Query: 261 LKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEII 320
++++ + ++ ++ K +++ E+ E+M + E ++ +++ ++ ++ ++ + +
Sbjct: 383 IQEQEEEMW---RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIREL 439
Query: 321 CNALQRQKERLEGENDLLKRENSRL 345
+Q Q+E+L + ++ E ++
Sbjct: 440 EEMMQDQEEKLREVEEKMQEEEEKM 464
Score = 49.7 bits (117), Expect = 5e-06
Identities = 53/237 (22%), Positives = 118/237 (49%), Gaps = 20/237 (8%)
Query: 116 VRGASIPFQFRPEN---EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSD 172
+R + Q RPEN EE + IE+ KE + EL + I+ ++ +
Sbjct: 160 LRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNTIT-DEELKE 218
Query: 173 MQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQ 232
AELQ+K L ++S +++L VK+ K + E QL Q++ E +++G +
Sbjct: 219 KNAELQEK---LRLVESEKSEIQLNVKDLKR--KLERAQLLLPQQQLQVEADRLGKELQS 273
Query: 233 LQAQLSTQ--EKEMEKLVQGDQDKT--EQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQ 288
+ A+L Q E E+ L+ Q++ Q E+++++ + + + R+ ++K+ + E+
Sbjct: 274 VSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEK 333
Query: 289 MKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
M + E +K +E D+ + +++ E E ++ Q+E++ + + ++ ++ ++
Sbjct: 334 MHEQE----EKIREQEDKMWRQEEKIREQE---EKIREQEEKMWRQEEKIREQDEKI 383
Score = 46.2 bits (108), Expect = 6e-05
Identities = 43/170 (25%), Positives = 89/170 (52%), Gaps = 8/170 (4%)
Query: 141 EVEEIEQHNKELCKENQE-LKDSCISLQKQNSDMQAELQKKQEELETLQSINK--KLELK 197
E+EE+ Q +E +E +E +++ +Q+Q +Q + +K QE+ E K K E K
Sbjct: 438 ELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEK 497
Query: 198 VKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQ---LSTQEKEMEKLVQGDQDK 254
+ EQ++ + ++ EQ +KM + EKM + ++++ Q L QE++M++ Q+
Sbjct: 498 IWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQEL 557
Query: 255 TEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQ--MKQNETTAMKKQQE 302
E+L +L ++ + L + E + + Q +K E ++++QQ+
Sbjct: 558 EERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQD 607
Score = 45.4 bits (106), Expect = 1e-04
Identities = 56/284 (19%), Positives = 136/284 (47%), Gaps = 28/284 (9%)
Query: 83 NKSAKQQEVQFKAYYLPK-----DDEYYQFCYVD---EDGVVRGASIPFQFRPENEEDIL 134
NK +Q +V+ K + P+ D++++Q ++ E+ RG R + ++D+
Sbjct: 37 NKLEQQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTK-----RWDEDDDLE 91
Query: 135 VVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSD-MQAELQKKQEEL-ETLQSINK 192
+ +E + +++ ++D+ +S K+NSD +++ +K+QE++ E + K
Sbjct: 92 ESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNEKNYTFRK 151
Query: 193 KLELK--------VKEQKDYWETELLQLK---EQNQKMSSENEKMGIRVDQLQAQLSTQE 241
++ +K V QK E LL+ + +M + EK+ D L +L
Sbjct: 152 RVVIKKPWLRLGEVTAQKRP-ENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNT 210
Query: 242 KEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQ 301
E+L + + + E+L ++ E + L++ + ++ ++ + + Q +Q + A + +
Sbjct: 211 ITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQ-QQLQVEADRLGK 269
Query: 302 ELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
EL + L ++ ENE+ Q+Q+E++ + + ++ + ++
Sbjct: 270 ELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKM 313
Score = 43.5 bits (101), Expect = 4e-04
Identities = 36/170 (21%), Positives = 88/170 (51%), Gaps = 17/170 (10%)
Query: 124 QFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEE 183
Q + E+D + + E+ E+ +EL + Q+ ++ ++++ + + ++Q+++E+
Sbjct: 411 QEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEK 470
Query: 184 LETLQSINKKLELKVKEQKD-YWETELL-----QLKEQNQKMSSENEKMGIRVDQLQAQL 237
++ + E K++EQ++ W E L ++ EQ +KM + EKM + +++Q Q
Sbjct: 471 IQ-------RQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQE 523
Query: 238 STQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVE 287
+++ EK+ + + +Q E+++++ + L E + KL Q E
Sbjct: 524 EKMQRQEEKMREQEVRLWQQEEKMQEQE----VRLQELEERLGKLGQKAE 569
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 68.9 bits (167), Expect = 9e-12
Identities = 54/209 (25%), Positives = 105/209 (50%), Gaps = 21/209 (10%)
Query: 143 EEIEQHNKELCK---ENQELKDSCISLQKQNSDMQAELQKK-------QEELETLQSINK 192
EE E+ +EL K + +EL++ ++L ++ +D+Q ++Q + +E + L
Sbjct: 858 EEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKI 917
Query: 193 KLELKVKEQKDYWETEL---LQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQ 249
+LE K+KE + E E +L + +K+ E ++ +D L+ L+ EKE
Sbjct: 918 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 977
Query: 250 GDQDKTEQLEQLKKENDHLFLSLTEQRKD-QKKLEQTVEQMKQNE---TTAMKKQQELMD 305
++ TE++ L D LT+++K Q+ +QT++ ++ E T K + +L
Sbjct: 978 KVKNLTEEMAGL----DETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQ 1033
Query: 306 ENFDLSKRLSENEIICNALQRQKERLEGE 334
+ DL L + + +C L+R K +LEG+
Sbjct: 1034 QVDDLEGSLEQEKKLCMDLERAKRKLEGD 1062
Score = 64.3 bits (155), Expect = 2e-10
Identities = 57/226 (25%), Positives = 106/226 (46%), Gaps = 17/226 (7%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQ- 188
+E L + Q +++E++ +EL +E + + S +KQ SD+ EL++ E LE
Sbjct: 1100 DEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG 1159
Query: 189 ------SINKKLELKVKEQKDYWETELLQLKEQ----NQKMSSENEKMGIRVDQLQAQLS 238
+NKK E + ++ + E LQ + +K + ++G ++D LQ
Sbjct: 1160 ATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQ 1219
Query: 239 TQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQ---NETT 295
EKE +L D +E + K + F + +DQ +T E+ +Q NE +
Sbjct: 1220 KLEKEKSELKMEINDLASNMETVSKAKAN-FEKMCRTLEDQLSEIKTKEEEQQRLINELS 1278
Query: 296 AMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
A K + L E+ + S++L E + + + L R K+ + + LKR+
Sbjct: 1279 AQKAR--LHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQ 1322
Score = 61.2 bits (147), Expect = 2e-09
Identities = 53/233 (22%), Positives = 115/233 (49%), Gaps = 23/233 (9%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
EED + T+ + + +EQ +L ++ K C+ L++ ++ +L+ QE T+ +
Sbjct: 1017 EEDKVNTLTKAKTK-LEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQES--TMDT 1073
Query: 190 INKKLELKVKEQKDYWETELLQLKEQNQK-----MSSENEKMGIRVDQLQAQLSTQEKEM 244
N K +L K +K +E LQ K ++++ + + +++ R+++L+ ++ +
Sbjct: 1074 ENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASR 1133
Query: 245 EKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMK--------QNETTA 296
K + D + +LE++ + + + + Q + KK E ++M+ Q+E TA
Sbjct: 1134 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATA 1193
Query: 297 MKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYM 349
+++ D +L +++ ++LQR K++LE E LK E + L S M
Sbjct: 1194 AALRKKHADSVAELGEQI-------DSLQRVKQKLEKEKSELKMEINDLASNM 1239
Score = 54.3 bits (129), Expect = 2e-07
Identities = 45/205 (21%), Positives = 97/205 (47%), Gaps = 17/205 (8%)
Query: 138 TQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELK 197
TQG +++ + H + + +LK+ ++++ + MQAE+++ + LE + K E
Sbjct: 1650 TQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAE-- 1707
Query: 198 VKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQ 257
ELL E+ Q + ++N + +L+ +S + EME +VQ ++ E+
Sbjct: 1708 ---------QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEK 1758
Query: 258 LEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSEN 317
++ + + E+ K ++ +E+MK+N +K Q +DE L+ + +
Sbjct: 1759 AKKAITD----AAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1814
Query: 318 EIICNALQRQKERLEGENDLLKREN 342
+I L+ + LE E + ++ N
Sbjct: 1815 QI--QKLEARVRELESEVESEQKHN 1837
Score = 51.2 bits (121), Expect = 2e-06
Identities = 51/226 (22%), Positives = 100/226 (44%), Gaps = 22/226 (9%)
Query: 132 DILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQA-------ELQKKQEEL 184
++ + + E E K L +E L ++ L K+ +Q +LQ +++++
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKV 1021
Query: 185 ETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEM 244
TL KLE +V + + E +E+ M E K + D AQ ST + E
Sbjct: 1022 NTLTKAKTKLEQQVDDLEGSLE------QEKKLCMDLERAKRKLEGDLKLAQESTMDTEN 1075
Query: 245 EKLVQGDQDKTEQLEQLK---KENDHLFLSLTEQRKDQ------KKLEQTVEQMKQNETT 295
+K ++ K ++ E K D L++ Q+K + ++LE+ +E + +
Sbjct: 1076 DKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAK 1135
Query: 296 AMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
A K++ +L E ++S+RL E +A ++ E E ++R+
Sbjct: 1136 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD 1181
Score = 50.8 bits (120), Expect = 2e-06
Identities = 42/193 (21%), Positives = 101/193 (52%), Gaps = 15/193 (7%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE 200
++ +I+ +++ +E + ++ + M EL+K+Q+ L+ + K +E VK+
Sbjct: 1737 DISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKD 1796
Query: 201 -QKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLE 259
Q E E L LK +++ +K+ RV +L++++ +++K + V+G + +++
Sbjct: 1797 LQLRLDEAEQLALKGGKKQI----QKLEARVRELESEVESEQKHNVEAVKGLRKHERRVK 1852
Query: 260 QLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEI 319
+L + + E RK+ +L+ V+++ Q + A K+Q E +E +++ L++
Sbjct: 1853 ELTYQTE-------EDRKNILRLQDLVDKL-QTKVKAYKRQAEEAEEQSNVN--LAKFRK 1902
Query: 320 ICNALQRQKERLE 332
+ + L+ KER +
Sbjct: 1903 LQHELEEAKERAD 1915
Score = 48.5 bits (114), Expect = 1e-05
Identities = 49/235 (20%), Positives = 119/235 (50%), Gaps = 26/235 (11%)
Query: 124 QFRPENEEDILVVTTQGEVEEIEQHNKELCKEN-QELKDSCISLQKQNSDMQAELQKKQE 182
+ + + EE+ +T + +H+ +L +E +E +++ LQ+ S +E+ + +
Sbjct: 1318 ELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRT 1377
Query: 183 ELET--------LQSINKKLELKVKEQKDYWE---TELLQLKEQNQKMSSENEKMGIRVD 231
+ ET L+ KKL ++++ +++ E ++ L++ Q++ +E E + I V+
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVE 1437
Query: 232 QLQAQ---LSTQEKEMEKLVQGDQDKTEQ----LEQLKKENDHLFLSLTEQRKDQKKLEQ 284
+ A L +++ +K++ + K E+ LE +KE+ L TE K + E+
Sbjct: 1438 RSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSL---STELFKVKNAYEE 1494
Query: 285 TVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLK 339
+++ ++ T ++ + L E DL+++++E + L++ K++L+ E L+
Sbjct: 1495 SLDHLE----TLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQ 1545
Score = 44.7 bits (104), Expect = 2e-04
Identities = 45/200 (22%), Positives = 90/200 (45%), Gaps = 35/200 (17%)
Query: 139 QGEVEE----IEQHNKE---LCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSIN 191
Q EVE+ +E+ N L K+ + +++ + QAEL+ Q+E +L +
Sbjct: 1426 QNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTEL 1485
Query: 192 KKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGD 251
K++ +E D+ ET LK +N+ + E + L Q++ K +
Sbjct: 1486 FKVKNAYEESLDHLET----LKRENKNLQQE-------ISDLTEQIAEGGKHI------- 1527
Query: 252 QDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLS 311
+LE++KK+ DH E+ + Q LE+ ++ E ++ Q EL ++
Sbjct: 1528 ----HELEKVKKQLDH------EKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEID 1577
Query: 312 KRLSENEIICNALQRQKERL 331
++++E + + L+R R+
Sbjct: 1578 RKIAEKDEELDQLKRNHLRV 1597
Score = 43.9 bits (102), Expect = 3e-04
Identities = 44/209 (21%), Positives = 96/209 (45%), Gaps = 18/209 (8%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE 200
++EE+++ +E K L + S + ++ + +++QE LQ K +V +
Sbjct: 1315 QIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQ 1374
Query: 201 QKDYWETELLQ----LKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTE 256
+ +ET+ +Q L+E +K++ + V+ + ++ ++ EK ++L Q++ E
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRL----QNEVE 1430
Query: 257 QLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSE 316
L + ++ ++L K Q+ ++ + + KQ + + E+ LS L +
Sbjct: 1431 DLMIDVERSNAACIALD---KKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFK 1487
Query: 317 NEIICNALQRQKERLEGENDLLKRENSRL 345
+ NA + + LE LKREN L
Sbjct: 1488 ---VKNAYEESLDHLE----TLKRENKNL 1509
Score = 39.7 bits (91), Expect = 0.006
Identities = 47/192 (24%), Positives = 92/192 (47%), Gaps = 22/192 (11%)
Query: 173 MQAELQKKQEELETLQSI--NKKLELKVKE---QKDYWETE-LLQLKEQNQKMSSENEKM 226
M+ E +K E E++ I N + + VK K Y++ + LL+ E ++M++ E+
Sbjct: 801 MRVEFRKMMERRESIFCIQYNIRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEF 860
Query: 227 GIRVDQLQAQLSTQEKEME-KLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQ------ 279
++L A+ + KE+E K+V Q+K + Q++ E D L+ E+R DQ
Sbjct: 861 EKTKEEL-AKTEAKRKELEEKMVTLMQEKNDLQLQVQAEAD--ALADAEERCDQLIKTKI 917
Query: 280 ------KKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEG 333
K++ + E ++ K+++L DE +L K + + E+ ++++K E
Sbjct: 918 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 977
Query: 334 ENDLLKRENSRL 345
+ L E + L
Sbjct: 978 KVKNLTEEMAGL 989
Score = 39.3 bits (90), Expect = 0.007
Identities = 48/228 (21%), Positives = 94/228 (41%), Gaps = 37/228 (16%)
Query: 114 GVVRGASIPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKD-------SCISL 166
G+ + S Q+R + E D + T EE+E+ K+L + Q+ ++ C SL
Sbjct: 1364 GMSKANSEVAQWRTKYETDAIQRT-----EELEEAKKKLAQRLQDAEEHVEAVNSKCASL 1418
Query: 167 QKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKM 226
+K +Q E++ ++E + L+ K+Q+++ + L + K++ ++ +E E
Sbjct: 1419 EKTKQRLQNEVEDLMIDVERSNAACIALD---KKQRNF-DKVLAEWKQKYEETQAELEAS 1474
Query: 227 GIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTV 286
Q + + E+ K+ ++ + LE LK+EN K L+Q +
Sbjct: 1475 -------QKESRSLSTELFKVKNAYEESLDHLETLKREN--------------KNLQQEI 1513
Query: 287 EQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGE 334
+ + K EL L SE + + E EG+
Sbjct: 1514 SDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGK 1561
Score = 34.3 bits (77), Expect = 0.24
Identities = 44/186 (23%), Positives = 85/186 (45%), Gaps = 45/186 (24%)
Query: 142 VEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQ 201
+E +++ NK L +E +L ++ AE K ELE KVK+Q
Sbjct: 1499 LETLKRENKNLQQEISDL-----------TEQIAEGGKHIHELE-----------KVKKQ 1536
Query: 202 KDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQL 261
D+ ++E LQ + + S E+E+ ++ ++Q +L+ + E+++ + +K E+L+QL
Sbjct: 1537 LDHEKSE-LQTSLEEAEASLEHEEG--KILRIQLELNQVKSEIDRKI---AEKDEELDQL 1590
Query: 262 KKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIIC 321
K+ +HL + VE M+ ++ + + + + L+E EI
Sbjct: 1591 KR--NHL---------------RVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQL 1633
Query: 322 NALQRQ 327
N RQ
Sbjct: 1634 NHANRQ 1639
Score = 30.8 bits (68), Expect = 2.6
Identities = 21/114 (18%), Positives = 53/114 (46%), Gaps = 1/114 (0%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ EVE ++HN E K ++ + L Q + + + + Q+ ++ LQ+ K + +
Sbjct: 1827 ESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQA 1886
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQ 252
+E ++ L + ++ ++ E+ I Q+ +L + +E+ V ++
Sbjct: 1887 EEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVN-KLRVKSREVHTKVISEE 1939
Score = 29.3 bits (64), Expect = 7.6
Identities = 21/109 (19%), Positives = 50/109 (45%), Gaps = 4/109 (3%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ V E+E + K N E +++ ++ + ++ ++ + LQ + KL+ KV
Sbjct: 1820 EARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKV 1879
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKL 247
K K E + +EQ+ ++ K+ +++ + + E ++ KL
Sbjct: 1880 KAYKRQAE----EAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKL 1924
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 68.6 bits (166), Expect = 1e-11
Identities = 44/200 (22%), Positives = 110/200 (55%), Gaps = 16/200 (8%)
Query: 149 NKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETE 208
N+EL K+N EL++ + + S++Q +++ + +LE + + +++ Q++ W E
Sbjct: 182 NEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTL-QEEMWRQE 240
Query: 209 LLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHL 268
+L+EQ +K+ + EKM + ++L+ Q ++ EK+ + ++ EQ ++L+++ L
Sbjct: 241 -EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKEL 299
Query: 269 FLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDL---SKRLSENEIICNALQ 325
++QKKL + EQM++ E ++++++ ++ + +RL E E ++
Sbjct: 300 --------REQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQE---KQMR 348
Query: 326 RQKERLEGENDLLKRENSRL 345
Q++++ + + + ++ RL
Sbjct: 349 EQEQKMRDQEERMWEQDERL 368
Score = 65.5 bits (158), Expect = 1e-10
Identities = 54/230 (23%), Positives = 121/230 (52%), Gaps = 17/230 (7%)
Query: 127 PENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELET 186
P+ + + L + EE+ + K++ K+ +++ L++Q M+ + +K + + +
Sbjct: 225 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKR 284
Query: 187 LQSINKKL---ELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQ---LSTQ 240
L+ K+L E +++EQK E E Q++EQ +KM + EKM + +++ Q L Q
Sbjct: 285 LREQEKELREQEKELREQKKLREQEE-QMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 343
Query: 241 EKEMEKLVQGDQDKTEQL----EQLKKENDHL-----FLSLTEQRKDQKKLEQTVEQMKQ 291
EK+M + Q +D+ E++ E+L+++ + + E+ ++++++ + ++M++
Sbjct: 344 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMRE 403
Query: 292 NETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
E T M++Q+E M + + E E L QKE+L + + ++E
Sbjct: 404 EEET-MREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQE 452
Score = 62.8 bits (151), Expect = 6e-10
Identities = 52/209 (24%), Positives = 109/209 (52%), Gaps = 16/209 (7%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ E EI+ + KEL ++ + K + Q Q + +Q E+ +++EEL ++ E K+
Sbjct: 200 ESEKSEIQLNVKELKRKLERAK--FLLPQVQTNTLQEEMWRQEEEL-------REQEKKI 250
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
++Q++ + +L+EQ KM + EKM + +L+ Q + +E EK ++ + EQ
Sbjct: 251 RKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQ-EKELREQEKELREQKKLREQE 309
Query: 259 EQLKKENDHLFLSLTEQRKDQKKL----EQTVEQMKQ--NETTAMKKQQELMDENFDLSK 312
EQ++++ + ++ + R+ ++K+ E+ EQ KQ + M+ Q+E M E + +
Sbjct: 310 EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLR 369
Query: 313 RLSENEIICNALQRQKERLEGENDLLKRE 341
E + Q+E+++ E + +RE
Sbjct: 370 EKEERMREQEKMWEQEEKMQEEERIRERE 398
Score = 60.8 bits (146), Expect = 2e-09
Identities = 48/213 (22%), Positives = 111/213 (52%), Gaps = 27/213 (12%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKL--ELKV 198
E E I + K++ +E + +++ +QKQ +M E ++K+ + + L +KL + K+
Sbjct: 390 EEERIREREKKMREEEETMREQEEKMQKQEENMW-EQEEKEWQQQRLPEQKEKLWEQEKM 448
Query: 199 KEQKD-YWETELLQLKEQNQKMSSEN-----EKMGIRVDQLQAQLSTQEKEMEKLVQGDQ 252
+EQ++ WE E ++++Q + E EKM + DQ+ Q + +K+ ++
Sbjct: 449 QEQEEKIWEQEE-KIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEE 507
Query: 253 DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSK 312
EQ E+L+++ E+ ++QKK+ Q E+M++ KK QE + +D +
Sbjct: 508 RMWEQDERLREKE--------ERMREQKKMWQQEEKMREE-----KKTQEQEKKTWDQEE 554
Query: 313 RLSENEIICNALQRQKERLEGENDLLKRENSRL 345
++ E E ++ +++++ E ++++ + ++
Sbjct: 555 KMREEE----RMREREKKMREEEEMMREQEEKM 583
Score = 59.7 bits (143), Expect = 5e-09
Identities = 45/201 (22%), Positives = 99/201 (49%), Gaps = 27/201 (13%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKL------ 194
E E + + K++ +E + +++ +Q+Q M+ + +K E+ E +Q +K+
Sbjct: 558 EEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEK 617
Query: 195 ------ELKVKEQKDY-WETELL------QLKEQNQKMSSENEKMGIRVDQLQAQLSTQE 241
E K++EQ++ WE E ++ EQ +KM + EKM + +++Q Q +
Sbjct: 618 MWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQ-EEKM 676
Query: 242 KEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQ 301
+E E+ +QG ++K + E+ + + E+ Q++ E+M++ K++
Sbjct: 677 REQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMRE-------KEE 729
Query: 302 ELMDENFDLSKRLSENEIICN 322
+ D+ + +RL E+E C+
Sbjct: 730 RIRDQKEKMQERLPEHEERCS 750
Score = 58.9 bits (141), Expect = 9e-09
Identities = 42/217 (19%), Positives = 112/217 (51%), Gaps = 26/217 (11%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINK--KLELKVKE 200
E++ + ++ ++ ++++D + Q M + ++ +E+ E ++ K + E K++E
Sbjct: 479 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMRE 538
Query: 201 QKDYWETELL------------QLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLV 248
+K E E +++E+ +KM E E M + +++Q Q ++ EK+
Sbjct: 539 EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMW 598
Query: 249 QGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENF 308
+ ++ EQ E++ ++ + ++ EQ ++ K EQ E+M + M++Q+E M +
Sbjct: 599 EQEEKMQEQEEKMWEQEEKMW----EQEEEDKMQEQ--EEMMWEQEEKMQEQEEKM---W 649
Query: 309 DLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+ +++ E E ++ Q+E+++G+ + ++ + ++
Sbjct: 650 EQEEKMREQE---EKMREQEEKMQGQEEKMREQEEKM 683
Score = 56.6 bits (135), Expect = 4e-08
Identities = 41/204 (20%), Positives = 97/204 (47%), Gaps = 13/204 (6%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINK-KLELKVKEQ 201
EE E +E +E + +Q M+ E + +++E +T K + E +++E+
Sbjct: 506 EERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRER 565
Query: 202 KDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQL 261
+ E ++EQ +KM + EKM + +++ Q +++ EK+ + ++ EQ E+
Sbjct: 566 EKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEED 625
Query: 262 KKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIIC 321
K + E +Q++ Q E+ + M++Q+E M E + + E
Sbjct: 626 KMQEQE------EMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEK---- 675
Query: 322 NALQRQKERLEGENDLLKRENSRL 345
++ Q+E+++G+ + ++ + ++
Sbjct: 676 --MREQEEKMQGQEEKMREQEEKM 697
Score = 46.6 bits (109), Expect = 5e-05
Identities = 33/156 (21%), Positives = 85/156 (54%), Gaps = 12/156 (7%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKL---E 195
Q + E++ + +++ ++ +E K +Q+Q M + +K QE+ E + +K+ E
Sbjct: 605 QEQEEKMWEQEEKMWEQEEEDK-----MQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQE 659
Query: 196 LKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKT 255
K++EQ++ + + +++EQ +KM + EKM + ++++ Q + EK+ G ++K
Sbjct: 660 EKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKM-WGQEEKM 718
Query: 256 EQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQ 291
E+++++ + + ++ K Q++L + E+ +
Sbjct: 719 WGQEEMREKEERI---RDQKEKMQERLPEHEERCSE 751
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 68.2 bits (165), Expect = 1e-11
Identities = 56/221 (25%), Positives = 116/221 (52%), Gaps = 19/221 (8%)
Query: 127 PENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELET 186
P+ + + L + EE+ + K++ K+ +++ L++Q M+ + +K + +
Sbjct: 263 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKR 322
Query: 187 LQSINKKL---ELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQL---QAQLSTQ 240
L+ K+L E +++EQK+ E E Q++EQ +KM + EKM + +++ + +L Q
Sbjct: 323 LREQEKELREQEKELREQKELREQEE-QMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 381
Query: 241 EKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQ 300
EK+M + Q +D+ E++ E D E+ ++Q+K+ + VE+M++ KK
Sbjct: 382 EKQMREQEQKMRDQEERM----WEQDERLREKEERMREQEKMWEQVEKMREE-----KKM 432
Query: 301 QELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
QE + D +++ E E I +R+K+ E E + ++E
Sbjct: 433 QEQEKKTRDQEEKMQEEERI---REREKKMREEEETMREQE 470
Score = 68.2 bits (165), Expect = 1e-11
Identities = 52/202 (25%), Positives = 109/202 (53%), Gaps = 15/202 (7%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQK 202
+ + + KEL ++ +EL++ L++Q MQ + +K E+ E ++ +K+ ++++
Sbjct: 321 KRLREQEKELREQEKELREQK-ELREQEEQMQEQEEKMWEQEEKMREQEEKMW---RQEE 376
Query: 203 DYWETELLQLKEQNQKMSSENEKM---GIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLE 259
WE E Q++EQ QKM + E+M R+ + + ++ QEK E++ + ++K Q E
Sbjct: 377 RLWEQEK-QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQ-E 434
Query: 260 QLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEI 319
Q KK D E+ ++++++ + ++M++ E T M++Q+E M + + E E
Sbjct: 435 QEKKTRDQ-----EEKMQEEERIREREKKMREEEET-MREQEEKMQKQEENMWEQEEKEW 488
Query: 320 ICNALQRQKERLEGENDLLKRE 341
L QKE+L + + ++E
Sbjct: 489 QQQRLPEQKEKLWEQEKMQEQE 510
Score = 67.0 bits (162), Expect = 3e-11
Identities = 43/200 (21%), Positives = 110/200 (55%), Gaps = 16/200 (8%)
Query: 149 NKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETE 208
N+EL K+N EL++ + + S++Q +++ + +LE + + +++ Q++ W E
Sbjct: 220 NEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTL-QEEMWRQE 278
Query: 209 LLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHL 268
+L+EQ +K+ + EKM + ++L+ Q ++ EK+ + ++ EQ ++L+++ L
Sbjct: 279 -EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL 337
Query: 269 FLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDL---SKRLSENEIICNALQ 325
++QK+L + EQM++ E ++++++ ++ + +RL E E ++
Sbjct: 338 --------REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQE---KQMR 386
Query: 326 RQKERLEGENDLLKRENSRL 345
Q++++ + + + ++ RL
Sbjct: 387 EQEQKMRDQEERMWEQDERL 406
Score = 64.3 bits (155), Expect = 2e-10
Identities = 59/222 (26%), Positives = 113/222 (50%), Gaps = 39/222 (17%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDM---------QAELQKKQEEL---ETLQ 188
E E I + K++ +E + +++ +QKQ +M Q L +++E+L E +Q
Sbjct: 448 EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ 507
Query: 189 SINKKL---ELKVKEQKDYWETELL-----QLKEQNQKMSSENEKMGIRVDQLQAQLSTQ 240
+K+ E K+++Q++ W E +++EQ +M + EKM DQ Q ++ Q
Sbjct: 508 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMR---DQEQ-KMWDQ 563
Query: 241 EKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQ 300
E+ MEK Q + KT E+ +E + + R+ +KK+ + E M++ E M++Q
Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERM-------REREKKMREEEEMMREQE-EKMQEQ 615
Query: 301 QELMDENFDLSKRLSENEIICNALQRQKERL-EGENDLLKRE 341
+E M E +++ E E +Q Q+E++ E E + ++E
Sbjct: 616 EEKMQEQ---EEKMWEQE---EKMQEQEEKMWEQEEKMWEQE 651
Score = 60.1 bits (144), Expect = 4e-09
Identities = 37/227 (16%), Positives = 115/227 (50%), Gaps = 30/227 (13%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKK------QEELETLQSINKKLEL 196
E++ + ++ ++ ++++D + Q M+ + Q++ QEE + ++ E
Sbjct: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596
Query: 197 KVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQ---- 252
K++E+++ + +++EQ +KM + EKM + +++Q Q ++ EK+ + ++
Sbjct: 597 KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE 656
Query: 253 --------------DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMK 298
+K ++ E+++++ + ++ ++K Q++ ++T +Q K E +M+
Sbjct: 657 QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMR 716
Query: 299 KQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
++++ M E ++ + E +Q Q+E+++ + + + + ++
Sbjct: 717 EREKKMREEEEMMREQEEK------MQEQEEKMQEQEEEMWEQEEKM 757
Score = 57.8 bits (138), Expect = 2e-08
Identities = 43/222 (19%), Positives = 111/222 (50%), Gaps = 25/222 (11%)
Query: 141 EVEEIEQHNKELCKENQELKDS------------CISLQKQNSDMQAELQKKQEELETLQ 188
E E++++ +++ ++ ++++D +++Q M + +K +++ + +
Sbjct: 502 EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
Query: 189 SINKKLELKVKEQ-KDYWETELL-----QLKEQNQKMSSENEKMGIRVDQLQAQLSTQEK 242
+++E K +EQ K W+ E +++E+ +KM E E M + +++Q Q ++
Sbjct: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621
Query: 243 EMEKLVQGDQDKTEQLEQLKKENDHLFLS---LTEQRKDQKKLEQTVEQMKQNETTAMKK 299
+ EK+ + ++ EQ E++ ++ + ++ + EQ++ ++ E+ E K E M++
Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
Query: 300 QQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
Q+E + E + K+ E E +E++ E + +RE
Sbjct: 682 QEEKIWEQEKMEKKTQEQE----KKTWDQEKMREEESMRERE 719
Score = 57.0 bits (136), Expect = 3e-08
Identities = 44/188 (23%), Positives = 98/188 (52%), Gaps = 12/188 (6%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKL--ELKV 198
E E + + K++ +E + +++ +Q+Q MQ + ++ E+ E + +K+ + ++
Sbjct: 711 EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRL 770
Query: 199 KEQKD-YWETELLQ----LKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQD 253
EQK+ WE E +Q + EQ +KM + EKM + ++++ Q + EK+ ++
Sbjct: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830
Query: 254 KTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKR 313
Q E++ + + ++ ++ K ++K++ E+M++ E M+ Q+E M E + R
Sbjct: 831 MWGQEEKMWGQEEKMW---GQEEKMEEKMQGQEEKMREQE-EKMRGQEEKMREQ-EEKMR 885
Query: 314 LSENEIIC 321
E +I C
Sbjct: 886 GQEEKIYC 893
Score = 55.8 bits (133), Expect = 8e-08
Identities = 41/208 (19%), Positives = 111/208 (53%), Gaps = 21/208 (10%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKK-QEELETLQSINKKLELKVKEQ 201
E++E+ +E + QE K + Q + E +KK +EE ET++ +K++ K++
Sbjct: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQ---KQE 477
Query: 202 KDYWETELLQLKEQNQKMSSENEKM--GIRVDQLQAQLSTQEKEM--EKLVQGDQDKTEQ 257
++ WE E + + Q Q++ + EK+ ++ + + ++ QE+++ ++ + G + K +
Sbjct: 478 ENMWEQE--EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR 535
Query: 258 LEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSEN 317
E+++++ D ++ + R ++K+ E+M+ KK QE + +D +++ E
Sbjct: 536 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERME-------KKTQEQEKKTWDQEEKMREE 588
Query: 318 EIICNALQRQKERLEGENDLLKRENSRL 345
E ++ +++++ E ++++ + ++
Sbjct: 589 E----RMREREKKMREEEEMMREQEEKM 612
Score = 55.5 bits (132), Expect = 1e-07
Identities = 48/211 (22%), Positives = 103/211 (48%), Gaps = 17/211 (8%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKL---ELKVK 199
EE + + + + +++++ +++Q MQ + +K QE+ E + +K+ E K+
Sbjct: 582 EEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMW 641
Query: 200 EQKD-YWET-----ELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQD 253
EQ++ WE E +L EQ +K+ + Q Q + ++++MEK Q +
Sbjct: 642 EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEK 701
Query: 254 KTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKR 313
KT E++++E S+ E+ K ++ E+ + + ++ +K QE +E ++ ++
Sbjct: 702 KTWDQEKMREEE-----SMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEK 756
Query: 314 LSENEIICNALQR---QKERLEGENDLLKRE 341
+ E E QR QKE+L + ++E
Sbjct: 757 MWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE 787
Score = 53.5 bits (127), Expect = 4e-07
Identities = 37/228 (16%), Positives = 117/228 (51%), Gaps = 13/228 (5%)
Query: 127 PENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDM-----QAELQKKQ 181
PE +E + E E++++ +++ E ++++ +K+ D + +++++
Sbjct: 661 PEQKEKLWEHEKMQEQEKMQEQEEKIW-EQEKMEKKTQEQEKKTWDQEKMREEESMRERE 719
Query: 182 EELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKM--GIRVDQLQAQLST 239
+++ + + ++ E K++EQ++ + + ++ EQ +KM + EKM R+ + + +L
Sbjct: 720 KKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 779
Query: 240 QEK--EMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAM 297
EK E EK+ + ++ +Q E+++ + + + + R ++K+ E+M E
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMW 839
Query: 298 KKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+++++ + + +++ E ++ Q+E++ G+ + ++ + ++
Sbjct: 840 GQEEKMWGQEEKMEEKMQGQE---EKMREQEEKMRGQEEKMREQEEKM 884
Score = 45.8 bits (107), Expect = 8e-05
Identities = 43/236 (18%), Positives = 112/236 (47%), Gaps = 46/236 (19%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQK------------------K 180
Q + E++++ +++ ++ +++++ + +Q M + +K K
Sbjct: 613 QEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK 672
Query: 181 QEELETLQS------INKKLELKVKEQ-KDYWETELLQ----LKEQNQKMSSENEKMGIR 229
+E E +Q +K+E K +EQ K W+ E ++ ++E+ +KM E E M +
Sbjct: 673 MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQ 732
Query: 230 VDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQM 289
+++Q Q EK+ + +++ EQ E++ ++ + ++ EQ++ ++ E+ E
Sbjct: 733 EEKMQEQ-------EEKMQEQEEEMWEQEEKMWEQEEKMW----EQQRLPEQKEKLWEHE 781
Query: 290 KQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
K E + +Q+E M + + + E ++ Q+E++ G+ + + + ++
Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQEEK------MRGQEEKMRGQEEKMWGQEEKM 831
Score = 29.6 bits (65), Expect = 5.8
Identities = 16/88 (18%), Positives = 45/88 (51%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+G+ E++ +++ + +++ + Q M + +K + E ++ + E K+
Sbjct: 804 RGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKM 863
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKM 226
+EQ++ + +++EQ +KM + EK+
Sbjct: 864 REQEEKMRGQEEKMREQEEKMRGQEEKI 891
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 67.8 bits (164), Expect = 2e-11
Identities = 52/222 (23%), Positives = 113/222 (50%), Gaps = 7/222 (3%)
Query: 123 FQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQE 182
++F E E+ + V TQ + + +++ +EL KE L + +++ + K QE
Sbjct: 159 WKFAGELEQALSAVATQKK--KADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE 216
Query: 183 ELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEK 242
+L+ ++S +++L VKE K E L L + Q++ +E + +G + + A+L Q +
Sbjct: 217 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQ--QQLQAEADHLGKELQSVSAKLQAQVE 274
Query: 243 EME---KLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKK 299
E E +L Q ++K + E+ +E + E+ ++Q++ + E+M + M++
Sbjct: 275 ENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRR 334
Query: 300 QQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
Q+E+M E + + L E ++ Q+E+ + E + ++E
Sbjct: 335 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE 376
Score = 62.8 bits (151), Expect = 6e-10
Identities = 41/216 (18%), Positives = 116/216 (53%), Gaps = 14/216 (6%)
Query: 141 EVEEIEQHNKELCKENQELK--DSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
E+EE + H +E +E +E + + I Q++ + +A++ +++E++ + ++ E +
Sbjct: 348 ELEE-KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMM 406
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
+EQ++ + ++ EQ ++M + EKM + ++++ Q ++ EK+ + ++ EQ
Sbjct: 407 QEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQE 466
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNE------TTAMKKQQELMDENFDLSK 312
E++ ++ + + ++ ++K+ + E++++ E +++Q+E+M E + K
Sbjct: 467 EKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEE--K 524
Query: 313 RLSENEIIC---NALQRQKERLEGENDLLKRENSRL 345
+ E +C +Q Q+E++ + + ++ + RL
Sbjct: 525 MWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRL 560
Score = 61.2 bits (147), Expect = 2e-09
Identities = 37/218 (16%), Positives = 115/218 (52%), Gaps = 5/218 (2%)
Query: 128 ENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETL 187
E EE I Q + E+I + +++ ++ + + + +++Q M + +K +E E +
Sbjct: 299 EREEKI-----QEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 353
Query: 188 QSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKL 247
K E + K Q++ E + +EQ KM + EK+ + ++++ Q +++ EK+
Sbjct: 354 HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKM 413
Query: 248 VQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDEN 307
+ ++ EQ E+++++ + + + R+ +KK+ + E++++ E ++++++ ++
Sbjct: 414 GEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQE 473
Query: 308 FDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+ ++ ++ + ++RQ+E++ + ++ + ++
Sbjct: 474 GKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKI 511
Score = 60.5 bits (145), Expect = 3e-09
Identities = 49/231 (21%), Positives = 113/231 (48%), Gaps = 35/231 (15%)
Query: 139 QGEVEEIEQHNKELCKE---------NQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
+ E EI+ + KEL ++ Q+L+ L K+ + A+LQ + EE E
Sbjct: 222 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 281
Query: 190 INKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQ 249
+N++ E K+ Q++ + +++EQ +K+ + EKM R +++ + + + E+++
Sbjct: 282 LNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMR-RQEEMMWEKEEKMRRQEEMMW 340
Query: 250 GDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTA------------- 296
++K +LE+ E + + EQ + +++ E+ EQ K+ E A
Sbjct: 341 EKEEKIRELEEKMHEQE----KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 396
Query: 297 --MKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+++Q+E+M E +++ E E + Q+E ++ + + ++R+ ++
Sbjct: 397 EKIREQEEMMQEQ---EEKMGEQE---EKMWEQEEEMQEQEEKMRRQEEKI 441
Score = 60.5 bits (145), Expect = 3e-09
Identities = 30/206 (14%), Positives = 114/206 (55%), Gaps = 3/206 (1%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKL---ELKVK 199
+E ++ +E +E ++ ++ + +Q ++ + +K +E+ E +Q +K+ E K+
Sbjct: 362 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMW 421
Query: 200 EQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLE 259
EQ++ + + +++ Q +K+ + +K+ + ++++ Q +++ EK+ + + EQ
Sbjct: 422 EQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEA 481
Query: 260 QLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEI 319
+++++ + + + R+ +KK+ + E++++ E ++++++ ++ + ++ + +
Sbjct: 482 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 541
Query: 320 ICNALQRQKERLEGENDLLKRENSRL 345
++RQ+E++ + L+++ ++
Sbjct: 542 QEEKMRRQEEKMREQEVRLRQQEEKM 567
Score = 60.1 bits (144), Expect = 4e-09
Identities = 41/203 (20%), Positives = 109/203 (53%), Gaps = 14/203 (6%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
E++ + + ++ E E+ +E + QE ++ +++ + + E+Q+++E++ +
Sbjct: 380 EQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEE 439
Query: 190 INKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQ 249
++ E K++EQ++ + ++EQ +KM + KM + ++Q Q ++ EK+ +
Sbjct: 440 KIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIRE 499
Query: 250 GDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFD 309
++ EQ E+++++ + + Q +++K EQ + +Q E M++Q+E M
Sbjct: 500 QEKKIREQEEKIREQEEMM------QEQEEKMWEQEEKMCEQEE--KMQEQEEKMRRQ-- 549
Query: 310 LSKRLSENEIICNALQRQKERLE 332
+++ E E+ L++Q+E+++
Sbjct: 550 -EEKMREQEV---RLRQQEEKMQ 568
Score = 56.6 bits (135), Expect = 4e-08
Identities = 39/177 (22%), Positives = 93/177 (52%), Gaps = 17/177 (9%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKL---ELK 197
E EE+ Q +E E +E + +Q +MQ + +K + + E ++ KK+ E K
Sbjct: 401 EQEEMMQEQEEKMGEQEE------KMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEK 454
Query: 198 VKEQKDYWETELLQLKEQN-------QKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQG 250
++EQ++ + + ++ EQ KM + EKM + ++++ Q ++ EK+ +
Sbjct: 455 IREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 514
Query: 251 DQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDEN 307
++ EQ E++ ++ + + + ++ ++K+ + E+M++ E +++Q+E M E+
Sbjct: 515 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQE-VRLRQQEEKMQEH 570
Score = 50.1 bits (118), Expect = 4e-06
Identities = 40/208 (19%), Positives = 109/208 (52%), Gaps = 23/208 (11%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
Q +VEE E N+ NQ+ ++ +++ + + ++Q+++E++ ++ E K+
Sbjct: 270 QAQVEENELWNRL----NQQQEEKMWRQEEKIQEREEKIQEQEEKI-------REQEEKM 318
Query: 199 KEQKD-YWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQ 257
+ Q++ WE E +++ Q + M + EK + +L+ ++ QEK E+ + +++ +
Sbjct: 319 RRQEEMMWEKE-EKMRRQEEMMWEKEEK----IRELEEKMHEQEKIREQEEKRQEEEKIR 373
Query: 258 LEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSEN 317
++ ++E + E+ ++Q++ + E+M Q + M +Q+E M ++ + + E
Sbjct: 374 EQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM---WEQEEEMQEQ 430
Query: 318 EIICNALQRQKERLEGENDLLKRENSRL 345
E ++RQ+E++ + ++ + ++
Sbjct: 431 E---EKMRRQEEKIREQEKKIREQEEKI 455
Score = 36.6 bits (83), Expect = 0.047
Identities = 34/136 (25%), Positives = 62/136 (45%), Gaps = 7/136 (5%)
Query: 214 EQNQKMSSENEKMGIRVDQLQAQ----LSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLF 269
E QK S ++++ R + Q Q L+ Q+ E++ + Q +QLE ++ L
Sbjct: 96 EDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARD---LI 152
Query: 270 LSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKE 329
L + K +LEQ + + + A + +EL E LS L N I L+ +
Sbjct: 153 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 212
Query: 330 RLEGENDLLKRENSRL 345
+L+ + L++ E S +
Sbjct: 213 KLQEKLQLVESEKSEI 228
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 67.4 bits (163), Expect = 3e-11
Identities = 52/245 (21%), Positives = 109/245 (44%), Gaps = 32/245 (13%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ ++E++ ++ K EL+ S +L++Q +M+ +L++ ++EL+ + +LE+ +
Sbjct: 1510 RADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM 1569
Query: 199 KEQKDYWETELLQLKEQNQKMS-------------------------SENEKMGIRVDQL 233
+ K +E +L EQN++ + +KM I + L
Sbjct: 1570 QAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDL 1629
Query: 234 QAQLSTQE-------KEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTV 286
+AQ+ K++ KL +D +LE+ + D +F E K K LE +
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689
Query: 287 EQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLL 346
Q+++ ++ + ++ E +L+ ++ + +AL +K RLE L+ E
Sbjct: 1690 LQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749
Query: 347 SYMGL 351
S M L
Sbjct: 1750 SNMEL 1754
Score = 60.5 bits (145), Expect = 3e-09
Identities = 54/225 (24%), Positives = 102/225 (45%), Gaps = 41/225 (18%)
Query: 130 EEDILVVTTQGEVE---EIEQHNKELCKENQELKDSCISL--------------QKQNSD 172
E++IL Q E E E E+ L + QEL++ L Q +
Sbjct: 888 EKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKK 947
Query: 173 MQAELQKKQEELETLQSINKKLELK---VKEQKDYWETELLQLKEQNQKMSSENEKMGIR 229
MQA +Q +E+L+ + +KL+L+ + + E E+L L++QN K E + M R
Sbjct: 948 MQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR 1007
Query: 230 VDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQM 289
+ + +QL+ +E +K + L +++ + + + L E+ K ++K Q +E+
Sbjct: 1008 IAECSSQLAEEE-----------EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKA 1056
Query: 290 KQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGE 334
K+ +L E DL +++E + + L+ Q + E E
Sbjct: 1057 KR----------KLDGETTDLQDQIAELQAQIDELKLQLAKKEEE 1091
Score = 58.2 bits (139), Expect = 2e-08
Identities = 49/205 (23%), Positives = 97/205 (47%), Gaps = 22/205 (10%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETL------QSINKKLEL 196
+E+E+ ++L E +L+D LQ Q +++ +L KK+EEL+ ++++K L
Sbjct: 1051 QELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL 1110
Query: 197 KVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTE 256
KV + + ++ +L+E + + K + L +L + E+E + + E
Sbjct: 1111 KVVRE---LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167
Query: 257 QLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSE 316
+ ++E L +L E+ K+ E ++ M+Q TA+ E + E + +KR
Sbjct: 1168 LRTKREQEVAELKKALEEETKNH---EAQIQDMRQRHATAL----EELSEQLEQAKRFKA 1220
Query: 317 NEIICNALQRQKERLEGENDLLKRE 341
N L++ K+ LE +N L E
Sbjct: 1221 N------LEKNKQGLETDNKELACE 1239
Score = 52.8 bits (125), Expect = 6e-07
Identities = 46/214 (21%), Positives = 96/214 (44%), Gaps = 7/214 (3%)
Query: 157 QELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQN 216
QEL D + L Q + + L+KKQ++ + L + K + + E++D E E + + +
Sbjct: 1427 QELDDLTVDLDHQRQ-VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKA 1485
Query: 217 QKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQR 276
++ E+ ++ + Q +ME L+ D + + +L+K L + E R
Sbjct: 1486 LSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR 1545
Query: 277 KDQKKLEQTVEQMKQNETTAMKKQQELMDENF--DLSKRLSENEIICNALQRQKERLEGE 334
++LE + Q ++ ++ + M F DL R +NE L +Q LE E
Sbjct: 1546 TQLEELEDEL-QATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAE 1604
Query: 335 NDLLKRENSRLLS---YMGLDFNSLPYQVPTSDE 365
+ +++ + ++ M +D L Q+ +++
Sbjct: 1605 LEDERKQRALAVASKKKMEIDLKDLEAQIEAANK 1638
Score = 48.9 bits (115), Expect = 9e-06
Identities = 50/214 (23%), Positives = 94/214 (43%), Gaps = 43/214 (20%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSC---ISLQKQNSDMQAELQKKQEELETLQSINKKLE 195
+GE+EE+E+ +++L +E L + L + +M+A L K++ELE I LE
Sbjct: 872 EGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELE---EILHDLE 928
Query: 196 LKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKT 255
+V+E++ E+NQ + +E +KM + QD
Sbjct: 929 SRVEEEE-----------ERNQILQNEKKKMQAHI---------------------QDLE 956
Query: 256 EQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLS 315
EQL++ + L L KK+E+ + ++ + +K+++ + D + S +L+
Sbjct: 957 EQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLA 1016
Query: 316 ENEIICNALQRQKERLEG-----ENDLLKRENSR 344
E E L + + + E E L K E +R
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR 1050
Score = 48.9 bits (115), Expect = 9e-06
Identities = 61/261 (23%), Positives = 107/261 (40%), Gaps = 53/261 (20%)
Query: 142 VEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELE-TLQSINKKLELKVKE 200
V E++ EL ++ + K S +KQ D+ EL+ + ELE TL + + EL+ K
Sbjct: 1113 VRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR 1172
Query: 201 QKDYWE------------------------TELLQLKEQNQ-----KMSSENEKMGIRVD 231
+++ E T L +L EQ + K + E K G+ D
Sbjct: 1173 EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD 1232
Query: 232 ------------QLQAQLSTQEKEMEKLVQ--------GDQDKTEQLEQ---LKKENDHL 268
Q++A+ + K+++ VQ GD+ + E E+ L+ E D++
Sbjct: 1233 NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV 1292
Query: 269 FLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQK 328
L E K K + ++ + QE + +LS R+ + E N+LQ Q+
Sbjct: 1293 STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ 1352
Query: 329 ERLEGENDLLKRENSRLLSYM 349
E E L+++ L S +
Sbjct: 1353 EEEEEARKNLEKQVLALQSQL 1373
Score = 48.1 bits (113), Expect = 2e-05
Identities = 44/216 (20%), Positives = 102/216 (47%), Gaps = 19/216 (8%)
Query: 136 VTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLE 195
VT + +++++E+ L +N + ++ + ++ ++L +++E+ + L I K E
Sbjct: 974 VTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQE 1033
Query: 196 LKV--------KEQKDYWETELLQLKEQNQKMSSENE--KMGIRVDQLQAQLSTQEKEME 245
+ + KE+K E E + K + +++ ++ ++D+L+ QL+ +E+E++
Sbjct: 1034 VMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQ 1093
Query: 246 -KLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELM 304
L +GD + + LK + E + +L++ E K + A K++++L
Sbjct: 1094 GALARGDDETLHKNNALK--------VVRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145
Query: 305 DENFDLSKRLSENEIICNALQRQKERLEGENDLLKR 340
+E L L + A Q + + E E LK+
Sbjct: 1146 EELEALKTELEDTLDTTAAQQELRTKREQEVAELKK 1181
Score = 47.8 bits (112), Expect = 2e-05
Identities = 50/220 (22%), Positives = 95/220 (43%), Gaps = 25/220 (11%)
Query: 129 NEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEEL--ET 186
+E D L V + +++ + +E + I K + ++++LQ QE L ET
Sbjct: 1269 SEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEET 1328
Query: 187 LQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEK 246
Q +N ++ E+ E L+EQ ++ + + +V LQ+QL+ +K+++
Sbjct: 1329 RQKLNLSSRIRQLEE------EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382
Query: 247 LVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQ--------------- 291
+ + E ++L K+ + L L E+ KLE+T +++Q
Sbjct: 1383 DLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQV 1442
Query: 292 --NETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKE 329
N KK +L+ E +S R +E A R+KE
Sbjct: 1443 ASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKE 1482
Score = 42.4 bits (98), Expect = 9e-04
Identities = 44/201 (21%), Positives = 89/201 (44%), Gaps = 14/201 (6%)
Query: 135 VVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAE---LQKKQEELETLQSIN 191
+ + E+EE EQ N EL N + + + + N+++ AE QK + L+ N
Sbjct: 1738 IAQLEEELEE-EQSNMELL--NDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQN 1794
Query: 192 KKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGD 251
K+L+ K++E + +++ +S+ K+G +QL+ Q + + KLV+
Sbjct: 1795 KELKAKLQELEGAVKSKF------KATISALEAKIGQLEEQLE-QEAKERAAANKLVRRT 1847
Query: 252 QDKTEQL-EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDL 310
+ K +++ Q++ E H + K +++Q Q+++ E A + +L
Sbjct: 1848 EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQREL 1907
Query: 311 SKRLSENEIICNALQRQKERL 331
NE + + K RL
Sbjct: 1908 DDATEANEGLSREVSTLKNRL 1928
Score = 41.6 bits (96), Expect = 0.001
Identities = 47/236 (19%), Positives = 111/236 (47%), Gaps = 30/236 (12%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAEL---QKKQEE--- 183
EE + + ++E+ L ++ +E +++ +L+KQ +Q++L +KK ++
Sbjct: 1326 EETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLG 1385
Query: 184 -LETLQSINKKLELKVKEQKDYWETELL---QLKEQNQKMSSENEKMGIRVD---QLQAQ 236
+E+L+ KKL + E + L +L++ ++ E + + + +D Q+ +
Sbjct: 1386 TIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASN 1445
Query: 237 LSTQEKEMEKLVQGDQ-------DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQM 289
L ++K+ ++L+ ++ ++ ++ E +E + LSL R ++ LE E
Sbjct: 1446 LEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLA--RALEEALEAKEEFE 1503
Query: 290 KQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+QN+ ++LM D+ K + E L++ K LE + + ++ + L
Sbjct: 1504 RQNKQLRAD-MEDLMSSKDDVGKNVHE-------LEKSKRALEQQVEEMRTQLEEL 1551
Score = 39.7 bits (91), Expect = 0.006
Identities = 49/230 (21%), Positives = 91/230 (39%), Gaps = 29/230 (12%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQK--------KQEELETLQSI 190
Q E+EE E+ +++E + SL+ + +Q EL +QE E I
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEI 1717
Query: 191 NKKLELK--VKEQKDYWETELLQLKEQNQKMSSENE-------KMGIRVDQLQAQLSTQE 241
K + ++K E + QL+E+ ++ S E K ++VD L A+L+ +
Sbjct: 1718 TNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER 1777
Query: 242 KEMEKLVQGDQD----------KTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQ 291
+K Q K ++LE K +S E + Q LE+ +EQ +
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQ--LEEQLEQEAK 1835
Query: 292 NETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
A K + + ++ ++ + + + Q E+ LKR+
Sbjct: 1836 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQ 1885
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 67.4 bits (163), Expect = 3e-11
Identities = 49/208 (23%), Positives = 105/208 (50%), Gaps = 11/208 (5%)
Query: 138 TQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELK 197
++GEVE ++ + + + + L+ ++++ + ++ ELQK+QE + L+ IN E
Sbjct: 2362 SKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENI 2421
Query: 198 VKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQ 257
++E+ E E +Q+KE K S+ E + ++ +L +++ + E +Q+ + Q
Sbjct: 2422 LQEK----EQEKVQMKE---KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQ 2474
Query: 258 LEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSEN 317
+E L+ E L L E + + L+ +V + Q +K ++ +E L ++ +
Sbjct: 2475 VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQ 2534
Query: 318 EIICNALQRQKERLEGENDLLKRENSRL 345
E + + L ++EGE+ L K +N L
Sbjct: 2535 EQLVSKL----SQVEGEHQLWKEQNLEL 2558
Score = 54.7 bits (130), Expect = 2e-07
Identities = 54/220 (24%), Positives = 107/220 (48%), Gaps = 18/220 (8%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV-- 198
++ ++E ++ ++N EL++ + L+++ +Q++ Q+ LE LQS K LE ++
Sbjct: 2540 KLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELEL 2599
Query: 199 -KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEK----EMEKLVQGDQD 253
K K + ++ ++ + ++ E +M + +LQ +LS ++ E++ L++ +
Sbjct: 2600 TKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKS 2659
Query: 254 KTEQLEQLKKENDHLFLSLTEQRKDQ----KKLEQTVEQMKQNETTAMKKQQELMDENFD 309
+QL++L EN L SL KDQ K+ + + + + A KK Q L+ D
Sbjct: 2660 SKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALL---LD 2716
Query: 310 LSKRLS-ENEIICNALQRQKERLEG---ENDLLKRENSRL 345
+K+ E + L ++E L E DLLK L
Sbjct: 2717 TNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEEL 2756
Score = 53.5 bits (127), Expect = 4e-07
Identities = 52/245 (21%), Positives = 109/245 (44%), Gaps = 37/245 (15%)
Query: 124 QFRPENEEDILV--VTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQ 181
Q EN+E +++ ++ EVE ++ +E+ + + + ++L+ + ++ ++Q+KQ
Sbjct: 2164 QMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ 2223
Query: 182 EELETLQSI----------NKKLELKVKEQ-KDYWETELLQLKEQNQKMSS--------- 221
+L L + ++ E+++KE+ K E QLKE N+ +++
Sbjct: 2224 GQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMK 2283
Query: 222 -----------ENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFL 270
E ++ +++L+A+L EK+ ++Q ++ + LK ++L
Sbjct: 2284 ATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLER 2343
Query: 271 SLTEQRKDQKKLEQTVEQMKQNETTAMKK----QQELMDENFDLSKRLSENEIICNALQR 326
L R +Q+ E K T K Q L D+ SE E + N LQ+
Sbjct: 2344 ELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQK 2403
Query: 327 QKERL 331
++ER+
Sbjct: 2404 EQERI 2408
Score = 52.4 bits (124), Expect = 8e-07
Identities = 56/221 (25%), Positives = 98/221 (44%), Gaps = 31/221 (14%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
E D L Q +E+ ++LC+ Q + S I K+N EL++ EE++ +
Sbjct: 438 ELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQI---KEN-----ELRRSMEEMKKENN 489
Query: 190 INKKLELKVKEQKDYWETELLQLKE-----QN--QKMSSENEKMGIRVDQLQAQLSTQEK 242
+ K + + + E EL +K+ QN ++M ++N + LQ +++ QE
Sbjct: 490 LLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQEN 549
Query: 243 EME----KLVQGDQDKTEQLEQ--LKKENDHLFL---SLTEQRKDQKKLEQTVEQMKQNE 293
+ KL D +K Q LKK H+ L++ K+ K L +E K
Sbjct: 550 SLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKK--- 606
Query: 294 TTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGE 334
K+ +EL +E S SENE + ++ +KE L+ +
Sbjct: 607 ----KEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSK 643
Score = 50.4 bits (119), Expect = 3e-06
Identities = 60/252 (23%), Positives = 115/252 (45%), Gaps = 32/252 (12%)
Query: 130 EEDILVVTTQG---EVEEIEQHNKELCK-----ENQELKDSCISLQKQNSDMQAELQKKQ 181
+++I+ T Q +EE Q + K E E K C+ Q + S+ A+L K +
Sbjct: 2278 DQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGR 2337
Query: 182 EELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQE 241
E ++ ++LE+ + +++ E K + + + ++ E M + L+ + T
Sbjct: 2338 VE-----NLERELEI-ARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIR 2391
Query: 242 KEMEKL---VQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMK 298
E E L +Q +Q++ +LE + +++ Q K+Q+K+ QMK+ +TAM+
Sbjct: 2392 SEKENLTNELQKEQERISELEIINSSFENIL-----QEKEQEKV-----QMKEKSSTAME 2441
Query: 299 KQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPY 358
Q + E + L ++ C A +++ L + + L+ E ++LL GLD Y
Sbjct: 2442 MLQTQLKELNERVAALHNDQEACKA---KEQNLSSQVECLELEKAQLL--QGLDEAKNNY 2496
Query: 359 QVPTSDEGGARQ 370
V S G Q
Sbjct: 2497 IVLQSSVNGLIQ 2508
Score = 50.4 bits (119), Expect = 3e-06
Identities = 55/236 (23%), Positives = 107/236 (45%), Gaps = 30/236 (12%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELET-LQSINKKLELKVK 199
E++ + KEL EN ELK S + K + + +++++ E + L KK + +
Sbjct: 2656 EIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLL 2715
Query: 200 EQKDYWETELLQLKEQ--NQKMSSENEKMGIRV-----DQLQAQLSTQEKEMEKLVQGDQ 252
+ +E E+ +E+ +++ ++K+ I + ++L L + +E+L +
Sbjct: 2716 DTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKM 2775
Query: 253 DKTEQLEQLKKENDH------LFLSLTEQRKDQKKLEQ------TVEQMKQNETTAM-KK 299
D + + QLKKEN+ L + +Q +++K++ Q Q KQ T M K
Sbjct: 2776 DNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTK 2835
Query: 300 QQELMDENFDLSKRLSEN--------EIICNALQRQKERLEGENDLLKRENSRLLS 347
EL E +L + L E + C+ L E+LE ++L+ + + L S
Sbjct: 2836 VDELTTEIKELKETLEEKTKEADEYLDKYCSLL-ISHEKLEKAKEMLETQVAHLCS 2890
Score = 48.5 bits (114), Expect = 1e-05
Identities = 60/301 (19%), Positives = 137/301 (45%), Gaps = 58/301 (19%)
Query: 80 DLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTTQ 139
+L+ +++ ++ +A YL D E VV+ + + EN++ ++V
Sbjct: 1903 ELSRIRSEKASIEHEALYLEADLE-----------VVQTEKLCLEKDNENKQKVIVC--- 1948
Query: 140 GEVEEIEQHNKELCKENQELKDSCISLQKQNS---DMQAELQKKQEELETLQS----INK 192
+E+ + E +L+ ++ K+ + + ++++K +ELE+ QS +
Sbjct: 1949 -----LEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQ 2003
Query: 193 KLELKVKEQKDYWET------ELLQ----LKEQNQKMSSENEKMGIRVDQLQAQLSTQEK 242
E +VKE+ + +T ELL+ L+E+ Q + +++ + + +L+ Q++ K
Sbjct: 2004 VAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNK 2063
Query: 243 EMEKLV-----------QGDQDK---TEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQ 288
E E LV + D +K ++ LE E L L+ +++ +L + +E+
Sbjct: 2064 EKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEK 2123
Query: 289 MKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGEND-----LLKRENS 343
++ KKQ + ++ L +R EN+ + + ++ + L+ + +L ENS
Sbjct: 2124 LRVRIEADEKKQLHIAEK---LKERERENDSLKDKVENLERELQMSEENQELVILDAENS 2180
Query: 344 R 344
+
Sbjct: 2181 K 2181
Score = 48.1 bits (113), Expect = 2e-05
Identities = 51/224 (22%), Positives = 103/224 (45%), Gaps = 27/224 (12%)
Query: 142 VEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE- 200
+++++ N+EL + EL+ + LQ +M+ ++ K QE LQ K+EL KE
Sbjct: 280 LDQLKAQNQELRNKINELE---LRLQGHEKEMKGQVNKFQEL--QLQLEKAKVELIEKEK 334
Query: 201 --------------QKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEK 246
Q D T+ L+++ +K++ + + + L + KE EK
Sbjct: 335 VLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEK 394
Query: 247 LVQGDQDKTEQ-LEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMD 305
Q + + ++ + L +E + LT++ + K + + Q + ++ T++K+Q E
Sbjct: 395 EFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVL-QAELDKLTSVKQQLENNL 453
Query: 306 ENFD-----LSKRLSENEIICNALQRQKERLEGENDLLKRENSR 344
E F + ++I N L+R E ++ EN+LLK + +
Sbjct: 454 EEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQ 497
Score = 47.8 bits (112), Expect = 2e-05
Identities = 48/209 (22%), Positives = 100/209 (47%), Gaps = 29/209 (13%)
Query: 146 EQHNKELCKENQELKD--SCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKD 203
EQ +E+C ELK+ C++ Q+ + E++ K ET+ + L+ K+ +Q++
Sbjct: 496 EQKAREVCHLEAELKNIKQCLN---QSQNFAEEMKAKNTSQETML---RDLQEKINQQEN 549
Query: 204 YWETELLQLKE---QNQKMSSEN--EKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
E L+L + Q+ S++ +K ++QL +LS EKE + L+ + K ++
Sbjct: 550 SLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEY 609
Query: 259 EQLKK----------ENDHLFLSLTEQRKD-QKKLEQ-----TVEQMKQNETTAMKKQQE 302
E+LK+ EN+ L + ++++ Q K+ +Q+K +E + E
Sbjct: 610 EELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLE 669
Query: 303 LMDENFDLSKRLSENEIICNALQRQKERL 331
+ EN + R N + +++ + ++L
Sbjct: 670 MDRENLSVEIRNLHNVLDSKSVEVETQKL 698
Score = 47.8 bits (112), Expect = 2e-05
Identities = 46/234 (19%), Positives = 104/234 (44%), Gaps = 20/234 (8%)
Query: 128 ENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETL 187
+ E ++ + E+EE+ Q N L + N L ++L +++ + ++++ + L
Sbjct: 955 KKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISEL 1014
Query: 188 QSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKL 247
K+ +L + ++ + L ++ + +N K+ +++ + ++ E+E+L
Sbjct: 1015 SDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQL 1074
Query: 248 VQG----DQDKTEQLEQLKKENDHLFLSL--------TEQRKDQKKLEQTVEQMKQNETT 295
+ Q+ +L ++ N +L L L +E +Q + +KQ T
Sbjct: 1075 KEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMT 1134
Query: 296 AMKKQQELMDENFDLSKRLSENEIICNALQRQKE--RLEGE---NDLLKRENSR 344
++Q ++ E DL L ENE + ++ + E LE E N + +RE+ R
Sbjct: 1135 LKEEQNKMQKEVNDL---LQENEQLMKVMKTKHECQNLESEPIRNSVKERESER 1185
Score = 46.6 bits (109), Expect = 5e-05
Identities = 51/221 (23%), Positives = 97/221 (43%), Gaps = 24/221 (10%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQK 202
+++++ ++L + Q + + SL+++ + + E Q EEL Q + L+ + + K
Sbjct: 362 QKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQ---EELSRQQRSFQTLDQECIQMK 418
Query: 203 DYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEM---EKLVQGDQDKTEQL- 258
EL Q K + + +E +K+ QL+ L ++++ E+ Q Q K +L
Sbjct: 419 ARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELR 478
Query: 259 ---EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQ---------NETTAMKKQQELMDE 306
E++KKEN+ L ++ ++ LE ++ +KQ E A QE M
Sbjct: 479 RSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR 538
Query: 307 NFDLSKRLSENEIICNALQRQKERLEGEND-----LLKREN 342
+ EN + L+ LE + D L KRE+
Sbjct: 539 DLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREH 579
Score = 44.7 bits (104), Expect = 2e-04
Identities = 59/270 (21%), Positives = 114/270 (42%), Gaps = 68/270 (25%)
Query: 131 EDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSI 190
+++ ++T E+E+ EL KEN +L + L+ + D Q LQ+ +ET + +
Sbjct: 1814 QEVQLMTKIEACIELEKIVGELKKENSDLSEK---LEYFSCDHQELLQR----VETSEGL 1866
Query: 191 NKKLEL------------KVKEQKDYWETELLQLKEQ-----NQKMSSENEKMGIRVD-- 231
N LE+ V + D W+ L ++ + ++K S E+E + + D
Sbjct: 1867 NSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLE 1926
Query: 232 -----------------------------------QLQAQLSTQEKE---MEKLVQGDQD 253
QL+ +L T K+ +++L + ++
Sbjct: 1927 VVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKE 1986
Query: 254 KTEQLEQLKKENDHLFLSLTEQRKDQKKLEQT----VEQMKQNETTAMKKQQELMDENFD 309
KT++LE + E H + K++ +L QT V ++ +++T +K Q L ++
Sbjct: 1987 KTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQA 2046
Query: 310 LSKRLSENEIICNALQRQKERLEGENDLLK 339
LS E E L ++KE L E++ L+
Sbjct: 2047 LSLTKCELENQIAQLNKEKELLVKESESLQ 2076
Score = 43.9 bits (102), Expect = 3e-04
Identities = 43/196 (21%), Positives = 93/196 (47%), Gaps = 21/196 (10%)
Query: 165 SLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENE 224
SL+ Q M ++LQK+ EEL ++ ++ +K ++ + E Q + Q+ +S ++
Sbjct: 838 SLESQKQ-MNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQ 896
Query: 225 KMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTE---------- 274
+ V + + L +EKE++ L + + ++++LKK N L SL E
Sbjct: 897 NV---VAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSL 953
Query: 275 QRKDQKKL----EQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKER 330
++K+ + ++ +E++ Q T + L E +L + ++E N + +++
Sbjct: 954 EKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNL---IQKSESFANYIDEREKS 1010
Query: 331 LEGENDLLKRENSRLL 346
+ +D K+E LL
Sbjct: 1011 ISELSDQYKQEKLILL 1026
Score = 43.9 bits (102), Expect = 3e-04
Identities = 55/218 (25%), Positives = 104/218 (47%), Gaps = 34/218 (15%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQEL-KDS-CISLQKQNSDMQ-AELQKKQE---- 182
E+ L+ T +V E+ + L ++ Q L KDS +SL K + Q A+L K++E
Sbjct: 2011 EKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVK 2070
Query: 183 ELETLQS-----------INKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVD 231
E E+LQ+ ++K LE + E+ ++ L +E+ ++ EK+ +R++
Sbjct: 2071 ESESLQARLSESDYEKLNVSKALEAALVEKGEF-ALRLSSTQEEVHQLRRGIEKLRVRIE 2129
Query: 232 -------QLQAQLSTQEKEMEKLVQGDQDKTEQLE---QLKKENDHLFLSLTEQRK-DQK 280
+ +L +E+E + L +DK E LE Q+ +EN L + E K + +
Sbjct: 2130 ADEKKQLHIAEKLKERERENDSL----KDKVENLERELQMSEENQELVILDAENSKAEVE 2185
Query: 281 KLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENE 318
L+ +E+M ++ L E +L+K++ E +
Sbjct: 2186 TLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ 2223
Score = 43.1 bits (100), Expect = 5e-04
Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 33/194 (17%)
Query: 145 IEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDY 204
I + KE +EN LKD +N + + ++ ++ +EL L + N K E++
Sbjct: 2138 IAEKLKERERENDSLKDKV-----ENLERELQMSEENQELVILDAENSKAEVET------ 2186
Query: 205 WETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKE 264
+ ++ E+M + + L T E E L + Q+K QL +L K
Sbjct: 2187 --------------LKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKL 2232
Query: 265 NDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKK-QQELMDENFDLSKRLSENEIICNA 323
F SL E++ EQ Q+K+ TA++ Q +L + N ++ + EI+
Sbjct: 2233 LSS-FKSLLEEK------EQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKAT 2285
Query: 324 LQRQKERLEGENDL 337
Q +E E+ L
Sbjct: 2286 EQSLDPPIEEEHQL 2299
Score = 41.6 bits (96), Expect = 0.001
Identities = 43/188 (22%), Positives = 90/188 (47%), Gaps = 14/188 (7%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE 200
+++E+E +L KE Q+ Q Q ++A LQK+++++E ++ L+ + +
Sbjct: 19 KIQELEGQLDKLKKEKQQR-------QFQLDSLEAALQKQKQKVENEKTEGTNLKRENQR 71
Query: 201 QKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQ 260
+ E+ L++ QK+S E + +V+ + QL++ +K++EKL Q + +LE+
Sbjct: 72 LMEICES----LEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELER 127
Query: 261 LKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEII 320
++ +SL QK + + + + +E ++ + KRL E
Sbjct: 128 SQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRL---EAE 184
Query: 321 CNALQRQK 328
ALQ +K
Sbjct: 185 VKALQAKK 192
Score = 38.5 bits (88), Expect = 0.012
Identities = 48/232 (20%), Positives = 97/232 (41%), Gaps = 15/232 (6%)
Query: 125 FRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEEL 184
++ ENE+ + + ++ E + + ++ E C + Q++K + + + +M E E+
Sbjct: 622 WKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRE--NLSVEI 679
Query: 185 ETLQSINKKLELKVKEQKDYWETELLQLKE-QNQKMSSENEKMGIRVDQLQAQLSTQEKE 243
L ++ ++V+ QK + EL Q E +QK E E M ++ QL Q+ E +
Sbjct: 680 RNLHNVLDSKSVEVETQKLAY-MELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHK 738
Query: 244 MEKLVQGDQDKT----------EQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNE 293
++ L DK E L L K D ++ + ++ +Q M +
Sbjct: 739 LQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQ-PAMHHSF 797
Query: 294 TTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+ +Q + E + ++ LQ + + LE + K+ NS L
Sbjct: 798 ANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDL 849
Score = 38.1 bits (87), Expect = 0.016
Identities = 59/262 (22%), Positives = 100/262 (38%), Gaps = 45/262 (17%)
Query: 131 EDILVVTTQ--GEVEEIEQHNKELCKENQELKDSCIS-LQKQNSDMQAELQKKQEELETL 187
E++ + T+Q G+VE++E H +L KD C L + ++ L+ K L T
Sbjct: 719 ENMCLKTSQLTGQVEDLE-HKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTN 777
Query: 188 QSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQ-------LQAQLSTQ 240
+ + L +Q+ + + M SE + + DQ LQ ++ +
Sbjct: 778 EDHQRSL--LAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSL 835
Query: 241 EKEMEKLVQGDQDKTEQLEQL------------KKENDHL-FLSLTEQR---------KD 278
E +E Q + D +Q E+L K E H F++ T QR
Sbjct: 836 EFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAH 895
Query: 279 QKKLEQTVEQMKQNET----------TAMKKQQELMDENFDLSKRLSENEIICNALQRQK 328
Q + +T+ ++ E T + QEL N L L E +++ L +K
Sbjct: 896 QNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEK 955
Query: 329 ERLEGENDLLKRENSRLLSYMG 350
+ + L KRE L G
Sbjct: 956 KEMSSIISLNKREIEELTQENG 977
Score = 36.6 bits (83), Expect = 0.047
Identities = 43/179 (24%), Positives = 69/179 (38%), Gaps = 19/179 (10%)
Query: 132 DILVVTTQGEVEEIEQHNKE---LCKENQELKDSCISLQKQNSDMQAELQKKQEELE--- 185
D L Q + +++E E L +ENQ L + C SL+K + ELQ K+ ++
Sbjct: 42 DSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQE 101
Query: 186 -TLQSINK---KLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQE 241
L S K KLE ++K K E + + ++ N I L
Sbjct: 102 GQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSG 161
Query: 242 KEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQ 300
+ E L + + E+ ++L+ E L KK QT+ Q N + Q
Sbjct: 162 SKYEDLKEKYNKEVEERKRLEAEVKAL---------QAKKASQTLPQATMNHRDIARHQ 211
Score = 35.0 bits (79), Expect = 0.14
Identities = 30/125 (24%), Positives = 58/125 (46%), Gaps = 17/125 (13%)
Query: 198 VKEQKDYWETELLQ----LKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQD 253
++E K+ T LQ L+ Q K+ E ++ ++D L+A L Q++++E +
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVEN------E 58
Query: 254 KTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVE------QMKQNETTAMKKQQELMDEN 307
KTE LK+EN L K ++K+ ++ ++ + + KKQ E +++
Sbjct: 59 KTEGTN-LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQE 117
Query: 308 FDLSK 312
K
Sbjct: 118 LKRCK 122
Score = 35.0 bits (79), Expect = 0.14
Identities = 32/108 (29%), Positives = 55/108 (50%), Gaps = 13/108 (12%)
Query: 163 CISLQKQN---SDMQAELQKKQEELETLQSINK----KLELKVKEQ-----KDYWETELL 210
C SLQ++N + + K EELE+L + + KLE K++ Q K+ E E L
Sbjct: 1528 CSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQL 1587
Query: 211 QLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
L + Q++ ++ +Q Q +L++ EME + ++ +TEQL
Sbjct: 1588 -LSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQL 1634
Score = 33.9 bits (76), Expect = 0.31
Identities = 23/89 (25%), Positives = 39/89 (43%), Gaps = 14/89 (15%)
Query: 246 KLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMD 305
+ +Q Q+ QL++LKKE L +K +Q VE K T ++ Q LM+
Sbjct: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLME 74
Query: 306 ENFDLSKRLSENEIICNALQRQKERLEGE 334
IC +L++ K+++ E
Sbjct: 75 --------------ICESLEKTKQKISHE 89
Score = 32.0 bits (71), Expect = 1.2
Identities = 40/175 (22%), Positives = 78/175 (44%), Gaps = 20/175 (11%)
Query: 164 ISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSEN 223
+S N+ + + QE++ LQ L+VKE + L ++++++K+ S
Sbjct: 1749 LSFSGPNALVPMDFLGNQEDIHNLQ-------LRVKETSNENLRLLHVIEDRDRKVESLL 1801
Query: 224 EKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLE 283
+M +L ++L QE ++ ++ + + + +LKKEN L L D ++L
Sbjct: 1802 NEM----KELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELL 1857
Query: 284 QTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKER-LEGENDL 337
Q VE + + ++ + D S R + + KER L+ EN+L
Sbjct: 1858 QRVETSEGLNSD--------LEMHADKSSREDIGDNVAKVNDSWKERFLDVENEL 1904
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 67.0 bits (162), Expect = 3e-11
Identities = 54/222 (24%), Positives = 113/222 (50%), Gaps = 10/222 (4%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
EE+ Q E ++++Q+ +EL ++ +E + + LQ + +A+L+K +EE L+
Sbjct: 926 EEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILED 985
Query: 190 INKKLELKVKEQKDY---WETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEK 246
N KL + K +D + T L + +E+++ ++ K + L+ +L +EK+ ++
Sbjct: 986 QNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQE 1045
Query: 247 L------VQGDQ-DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKK 299
L ++GD D ++Q+ +L+ + L + L ++ ++ + VE+ + A+KK
Sbjct: 1046 LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKK 1105
Query: 300 QQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
+EL + +L + L N ++QK L E + LK E
Sbjct: 1106 IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTE 1147
Score = 63.9 bits (154), Expect = 3e-10
Identities = 50/206 (24%), Positives = 106/206 (51%), Gaps = 19/206 (9%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELK---VK 199
+E+E+ +L +E ++ C LQ + MQ +Q+ +E+LE +S +KL+L+ +
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE 970
Query: 200 EQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLE 259
+ E E + L++QN K++ E + + R+ + L+ +E +K++ L
Sbjct: 971 AKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE-----------EKSKSLA 1019
Query: 260 QLKKENDHLFLSLTE----QRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLS 315
+LK +++ + L E + K +++LE+T +++ + T + EL + +L +L+
Sbjct: 1020 KLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA 1079
Query: 316 -ENEIICNALQRQKERLEGENDLLKR 340
+ E + AL R +E +N LK+
Sbjct: 1080 KKEEELQAALARVEEEAAQKNMALKK 1105
Score = 62.0 bits (149), Expect = 1e-09
Identities = 52/216 (24%), Positives = 101/216 (46%), Gaps = 26/216 (12%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQK 202
+E+E+ ++L ++ +L D LQ Q ++++ +L KK+EEL+ + +V+E+
Sbjct: 1044 QELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALA-------RVEEEA 1096
Query: 203 DYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLK 262
L +++E ++S +LQ L ++ K + +D E+LE LK
Sbjct: 1097 AQKNMALKKIRELESQIS-----------ELQEDLESERASRNKAEKQKRDLGEELEALK 1145
Query: 263 KENDHLFLSLTEQRKDQKKLEQTV--------EQMKQNETTAMKKQQELMDENFDLSKRL 314
E + S Q++ + K EQ V E+ K +E + +Q+ +L+++L
Sbjct: 1146 TELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQL 1205
Query: 315 SENEIICNALQRQKERLEGENDLLKRENSRLLSYMG 350
+ + + L++ K+ LE E L E LL G
Sbjct: 1206 EQTKRVKANLEKAKQTLENERGELANEVKVLLQGKG 1241
Score = 57.0 bits (136), Expect = 3e-08
Identities = 53/207 (25%), Positives = 97/207 (46%), Gaps = 23/207 (11%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE 200
+V ++ K + QEL D + L Q L+KKQ++ + L + K + K E
Sbjct: 1404 KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA-CNLEKKQKKFDQLLAEEKTISAKYAE 1462
Query: 201 QKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQ 260
++D E E + E E + + + + Q+ E+E+L Q +TE +E
Sbjct: 1463 ERDRAEAE-----------AREKETKALSLARALEEAMEQKAELERL--NKQFRTE-MED 1508
Query: 261 LKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEII 320
L D + S+ E K ++ LEQ VE+MK T +++ ++ + D RL E+
Sbjct: 1509 LMSSKDDVGKSVHELEKSKRALEQQVEEMK----TQLEELEDELQATEDAKLRL---EVN 1561
Query: 321 CNALQRQKER-LEGENDLLKRENSRLL 346
A++ Q ER L+G ++ + + +L+
Sbjct: 1562 LQAMKAQFERDLQGRDEQSEEKKKQLV 1588
Score = 57.0 bits (136), Expect = 3e-08
Identities = 47/213 (22%), Positives = 100/213 (46%), Gaps = 27/213 (12%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE 200
E+E++ ++ K EL+ S +L++Q +M+ +L++ ++EL+ + +LE+ ++
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQA 1564
Query: 201 QKDYWETELLQLKEQNQKMSSENEKMGIR-VDQLQAQLSTQEKEMEKLV----------- 248
K +E +L EQ S E +K +R V +++A+L + K+ V
Sbjct: 1565 MKAQFERDLQGRDEQ----SEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK 1620
Query: 249 -------QGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQ 301
++++ E ++QL+K + + E + E+ + Q K+NE KK +
Sbjct: 1621 DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENE----KKLK 1676
Query: 302 ELMDENFDLSKRLSENEIICNALQRQKERLEGE 334
+ E L + L+ E Q++++ L E
Sbjct: 1677 SMEAEMIQLQEELAAAERAKRQAQQERDELADE 1709
Score = 53.9 bits (128), Expect = 3e-07
Identities = 39/208 (18%), Positives = 102/208 (49%), Gaps = 3/208 (1%)
Query: 136 VTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLE 195
VTT+ +++++E+ L +N +L L+ + ++ L +++E+ ++L + K E
Sbjct: 967 VTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHE 1026
Query: 196 LKVKEQKDYWETELLQ---LKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQ 252
+ + ++ E Q L++ +K+ ++ + ++ +LQAQ++ + ++ K + Q
Sbjct: 1027 AMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQ 1086
Query: 253 DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSK 312
++E+ + + + E +L++ +E + + A K++++L +E L
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146
Query: 313 RLSENEIICNALQRQKERLEGENDLLKR 340
L + A Q + + E E ++LK+
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKK 1174
Score = 51.6 bits (122), Expect = 1e-06
Identities = 60/294 (20%), Positives = 138/294 (46%), Gaps = 40/294 (13%)
Query: 77 LPIDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVV 136
L ++L+N + + K+ L KD + D +++ EN + + +
Sbjct: 1278 LQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ---------EENRQKLSLS 1328
Query: 137 TTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAE---LQKKQEE----LETLQS 189
T +VE+ + +E +E +E K + L+KQ + + A+ ++KK E+ LET +
Sbjct: 1329 TKLKQVEDEKNSFREQLEEEEEAKHN---LEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385
Query: 190 INKKLELKVKEQKDYWETELL---QLKEQNQKMSSENEKMGIRVD---QLQAQLSTQEKE 243
+ +KL+ ++ E ++ +L++ ++ E + + + +D Q L ++K+
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Query: 244 MEKLVQGDQ-------DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTA 296
++L+ ++ ++ ++ E +E + LSL ++ + + +E++ + T
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 297 MKKQQELMDENFDLSKRLSENEIICNALQRQKERL-----EGENDLLKRENSRL 345
M ++LM D+ K + E E AL++Q E + E E++L E+++L
Sbjct: 1506 M---EDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL 1556
Score = 51.2 bits (121), Expect = 2e-06
Identities = 48/210 (22%), Positives = 99/210 (47%), Gaps = 31/210 (14%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQN-----SDMQAELQKKQEELETLQSINKKLE 195
+++E Q ELC E +EL+ + ++ +KQ D++A +++++E + LQ+ KK++
Sbjct: 884 QLQEQLQAETELCAEAEELR-ARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQ 942
Query: 196 LKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKT 255
++E L+EQ ++ S +K+ + +A+L E+E L +
Sbjct: 943 QNIQE-----------LEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLA 991
Query: 256 EQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLS 315
++ + L+ +LTE+ + K L + +K + E M DL +RL
Sbjct: 992 KEKKLLEDRIAEFTTNLTEEEEKSKSLAK------------LKNKHEAMIT--DLEERLR 1037
Query: 316 ENEIICNALQRQKERLEGENDLLKRENSRL 345
E L++ + +LEG++ L + + L
Sbjct: 1038 REEKQRQELEKTRRKLEGDSTDLSDQIAEL 1067
Score = 49.7 bits (117), Expect = 5e-06
Identities = 65/285 (22%), Positives = 125/285 (43%), Gaps = 47/285 (16%)
Query: 79 IDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTT 138
++ + ++ +QQ + K +DE ED +R + + E D+
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQ----ATEDAKLRLEVNLQAMKAQFERDL----- 1573
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQ----SINKKL 194
QG E+ E+ K+L ++ +E++ +KQ S A +K + +L+ L+ S NK
Sbjct: 1574 QGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNR 1633
Query: 195 ELKVK-------EQKDYW----------ETELLQLKEQNQKMSSENEKMGIRVDQLQAQL 237
+ +K + KD E L Q KE +K+ S M + QLQ +L
Sbjct: 1634 DEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS----MEAEMIQLQEEL 1689
Query: 238 STQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNE---- 293
+ E+ Q Q++ E +++ + L+L E+R+ + ++ Q E++++ +
Sbjct: 1690 AAAERAKR---QAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTE 1746
Query: 294 --TTAMKKQQELMDE-NFDLSKRLS---ENEIICNALQRQKERLE 332
+KK +D+ N DL+ S +NE L+RQ + L+
Sbjct: 1747 LINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELK 1791
Score = 48.1 bits (113), Expect = 2e-05
Identities = 52/232 (22%), Positives = 102/232 (43%), Gaps = 35/232 (15%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELE-TLQSINKKLELKVK 199
++ E+E EL ++ + + S +KQ D+ EL+ + ELE TL S + EL+ K
Sbjct: 1105 KIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSK 1164
Query: 200 EQKDY----------WETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEK------- 242
+++ +T Q++E QK S E++ +++Q + + EK
Sbjct: 1165 REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLEN 1224
Query: 243 -------EMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETT 295
E++ L+QG D + ++++ + L + E + + +L V
Sbjct: 1225 ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV--------- 1275
Query: 296 AMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLS 347
K Q EL + LS+ S++ + + +L+ +LL+ EN + LS
Sbjct: 1276 -TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326
Score = 47.4 bits (111), Expect = 3e-05
Identities = 45/186 (24%), Positives = 86/186 (46%), Gaps = 14/186 (7%)
Query: 172 DMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELL-QLKEQNQKMSSENEKMGIRV 230
+ Q + + E+ETLQS +L+++EQ ETEL + +E +++++ +++
Sbjct: 859 EKQLAAENRLTEMETLQSQLMAEKLQLQEQLQA-ETELCAEAEELRARLTAKKQELEEIC 917
Query: 231 DQLQAQLSTQEK-------EMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLE 283
L+A++ +E+ E +K+ Q Q+ EQLE+ + L L KKLE
Sbjct: 918 HDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLE 977
Query: 284 QTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEG-----ENDLL 338
+ ++ K+++ L D + + L+E E +L + K + E E L
Sbjct: 978 EEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLR 1037
Query: 339 KRENSR 344
+ E R
Sbjct: 1038 REEKQR 1043
Score = 42.4 bits (98), Expect = 9e-04
Identities = 60/257 (23%), Positives = 104/257 (40%), Gaps = 37/257 (14%)
Query: 135 VVTTQGEVEEIEQHNKELCKENQELKDSCISLQ-------KQNSDMQAELQKKQEELETL 187
++ Q E+ E+ ++ +E EL D + ++ ++A + + +EELE
Sbjct: 1682 MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE 1741
Query: 188 QS----INKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKE 243
Q IN +L+ K Q D T+L + QK NE ++++ +L + +E
Sbjct: 1742 QGNTELINDRLK-KANLQIDQINTDLNLERSHAQK----NENARQQLERQNKELKVKLQE 1796
Query: 244 MEKLVQGD--------QDKTEQLE-QLKKENDHLFLSLTEQRKDQKKLE----------Q 284
ME V+ + K QLE QL E + + R+ +KKL+ +
Sbjct: 1797 MEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERR 1856
Query: 285 TVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSR 344
EQ K A + ++L + + + LQR+ E D + RE S
Sbjct: 1857 NAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSS 1916
Query: 345 LLSYMGLDFNSLPYQVP 361
L + L LP+ VP
Sbjct: 1917 LKN--KLRRGDLPFVVP 1931
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/190 (23%), Positives = 90/190 (47%), Gaps = 23/190 (12%)
Query: 179 KKQEELETLQSINKKLELKVKEQKDYW------ETELLQLKEQNQKM-SSENEKMGIRVD 231
K+Q++L ++ + + +K + W LLQ+ Q ++M + E E + +R
Sbjct: 801 KRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREK 860
Query: 232 QLQAQ--LSTQEKEMEKLVQGDQDKTEQLE---QLKKENDHLFLSLTEQRKDQKK----L 282
QL A+ L+ E +L+ EQL+ +L E + L LT ++++ ++ L
Sbjct: 861 QLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDL 920
Query: 283 EQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQK-------ERLEGEN 335
E VE+ ++ +++++ +L ++L E E LQ +K ++LE E
Sbjct: 921 EARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQ 980
Query: 336 DLLKRENSRL 345
+L+ +N +L
Sbjct: 981 IILEDQNCKL 990
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 67.0 bits (162), Expect = 3e-11
Identities = 50/235 (21%), Positives = 110/235 (46%), Gaps = 32/235 (13%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ E+E++ ++ K EL+ S +L+ Q +M+ +L++ ++EL+ + +LE+ +
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1569
Query: 199 KEQKDYWETELLQLKEQNQK---------------MSSENEKMGIRV---DQLQAQLSTQ 240
+ K +E +L EQN++ + E ++ + +L+ L
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1629
Query: 241 EKEMEKLVQGDQDKTEQLEQLKKE--------------NDHLFLSLTEQRKDQKKLEQTV 286
E + + ++G ++ +QL +L+ + D +F + E K K LE +
Sbjct: 1630 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1689
Query: 287 EQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
Q++++ A + +++ E +L++ L+ + NALQ +K RLE L+ E
Sbjct: 1690 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Score = 61.6 bits (148), Expect = 1e-09
Identities = 57/227 (25%), Positives = 106/227 (46%), Gaps = 24/227 (10%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ +EE E ++L E +++ + L++Q + +A QK Q E T ++ KKLE ++
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 987
Query: 199 -----------KEQKDYWE------TELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQE 241
KE+K E T L + +E+ + ++ K + +L+ +L +E
Sbjct: 988 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1047
Query: 242 K---EMEKL---VQGD-QDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNET 294
K E+EKL ++GD D EQ+ L+ + L + L ++ ++ + ++ +
Sbjct: 1048 KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKN 1107
Query: 295 TAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
A+KK +EL DL + L N ++QK L E + LK E
Sbjct: 1108 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154
Score = 58.9 bits (141), Expect = 9e-09
Identities = 52/223 (23%), Positives = 110/223 (49%), Gaps = 27/223 (12%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
E + + V + +E+E+ E+ +E +D LQ + M ++ +E+LE ++
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 190 INKKLEL-------KVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEK 242
+KL+L K+K+ +D E+L + +QN K+S E + + R+ L L+ +E
Sbjct: 965 ARQKLQLEKVTAEAKIKKLED----EILVMDDQNNKLSKERKLLEERISDLTTNLAEEE- 1019
Query: 243 EMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQN-ETTAMKKQQ 301
+K + L +LK +++ + L + K ++K Q +E++K+ E A +
Sbjct: 1020 ----------EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069
Query: 302 ELMD---ENFDLSKRLS-ENEIICNALQRQKERLEGENDLLKR 340
++ D + +L +L+ + E + AL R + + +N+ LK+
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Score = 57.0 bits (136), Expect = 3e-08
Identities = 56/209 (26%), Positives = 102/209 (48%), Gaps = 31/209 (14%)
Query: 164 ISLQKQNSDMQA---ELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQ-KM 219
+ + +Q +MQA ELQK +E + ++ K+LE K + + E LLQ + Q + ++
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE--EKNLLQEQLQAETEL 902
Query: 220 SSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQ 279
+E E+M +R+ + +L EME ++ ++D+ +QL+ +K+ L L EQ +++
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 280 ------------------KKLEQTVEQMKQNETTAMKKQQELMDENF-DLSKRLSENEII 320
KKLE + M ++ + K+++L++E DL+ L+E E
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVM-DDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 321 CNALQRQKERLEG-----ENDLLKRENSR 344
L + K + E E L K E SR
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSR 1050
Score = 56.2 bits (134), Expect = 6e-08
Identities = 51/209 (24%), Positives = 101/209 (48%), Gaps = 30/209 (14%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSC---ISLQKQNSDMQAELQKKQEELETLQSINKKLE 195
+ E++E+EQ + +L +E L++ L + +M+ L K++ELE I ++E
Sbjct: 872 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE---EILHEME 928
Query: 196 LKVKEQKDYWET----------ELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEME 245
+++E++D + ++L L+EQ ++ + +K ++++++ A+ ++ E E
Sbjct: 929 ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK--LQLEKVTAEAKIKKLEDE 986
Query: 246 KLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMD 305
LV DQ+ +L KE L E+R E+ K T +K + E M
Sbjct: 987 ILVMDDQN-----NKLSKER-----KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036
Query: 306 ENFDLSKRLSENEIICNALQRQKERLEGE 334
+L RL + E L++ K +LEG+
Sbjct: 1037 S--ELEVRLKKEEKSRQELEKLKRKLEGD 1063
Score = 53.9 bits (128), Expect = 3e-07
Identities = 52/223 (23%), Positives = 105/223 (47%), Gaps = 21/223 (9%)
Query: 142 VEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQ 201
VEE+ + ++ + L + +L+K+N+D+ EL+ + + ++ KKLE +V+E
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 202 KDYWETELLQLKEQNQK-------------MSSENEKMGIRVDQLQAQLSTQEKEMEKLV 248
+ E N K M +E E I++ + A LS+Q ++ ++L+
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324
Query: 249 QGDQ----DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELM 304
Q + + + +L QL++E + L L E+ + ++ LE+ + + + + KK Q+
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384
Query: 305 D--ENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
E + K+ + EI L +Q E D L++ +RL
Sbjct: 1385 STVEALEEGKKRFQKEI--ENLTQQYEEKAAAYDKLEKTKNRL 1425
Score = 50.1 bits (118), Expect = 4e-06
Identities = 60/239 (25%), Positives = 108/239 (45%), Gaps = 33/239 (13%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEEL--ETLQSINKKLELK- 197
+V +++ + + E + I L K + + ++LQ QE L ET Q +N +L+
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 198 VKEQKDYWETELLQLKEQNQKMSSENEKMGIRVD----QLQAQLSTQE----------KE 243
++E+++ + +L + E Q + + I++ +LQ ST E KE
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 244 MEKLVQGDQDKTEQLEQLKK-------ENDHLFLSLTEQR-------KDQKKLEQTVEQM 289
+E L Q ++K ++L+K E D L + L QR K Q+K +Q + +
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460
Query: 290 KQ-NETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLS 347
K + A ++ + + +K LS + AL+ KE LE N +LK E L+S
Sbjct: 1461 KNISSKYADERDRAEAEAREKETKALSLARALEEALE-AKEELERTNKMLKAEMEDLVS 1518
Score = 49.3 bits (116), Expect = 7e-06
Identities = 59/256 (23%), Positives = 106/256 (41%), Gaps = 43/256 (16%)
Query: 130 EEDILVVTTQGEV---------EEIEQHNKELCKENQELKDSCISLQKQNS---DMQAEL 177
E++ILV+ Q E I L +E ++ K+ K S +++ L
Sbjct: 984 EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1043
Query: 178 QKKQEELETLQSINKKLELKVK---EQKDYWETELLQLKEQNQKMSSENEKMGIRVD--- 231
+K+++ + L+ + +KLE EQ + ++ +LK Q K E + R+D
Sbjct: 1044 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1103
Query: 232 ------------------QLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLT 273
LQ L ++ K + +D E+LE LK E + S
Sbjct: 1104 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1163
Query: 274 EQRKDQKKLEQTVEQMKQ---NETTAMKKQ-QELMDENFDLSKRLSENEIICNALQRQKE 329
Q++ + K EQ V +K+ ET + + Q QE+ ++ + L+E +R K
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ---LEQFKRAKA 1220
Query: 330 RLEGENDLLKRENSRL 345
L+ L++EN+ L
Sbjct: 1221 NLDKNKQTLEKENADL 1236
Score = 49.3 bits (116), Expect = 7e-06
Identities = 33/165 (20%), Positives = 74/165 (44%), Gaps = 11/165 (6%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
Q ++++ ++ ++ E+ + +K+ ++A+L + QE+L + K+ +L+
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
+E + EL + E ++ R+ QL+ +L ++ ME + + T+Q
Sbjct: 1711 EELAE----ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQEL 303
EQL E L +R +K E +Q+++ K E+
Sbjct: 1767 EQLSNE-------LATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Score = 47.0 bits (110), Expect = 4e-05
Identities = 47/230 (20%), Positives = 99/230 (43%), Gaps = 38/230 (16%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV---- 198
+E+E K+L + QEL+ C ++ +++ ++ K Q E+E++ + + E K
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307
Query: 199 --------------------KEQKDYWETELLQLKEQNQKMSSE-NEKMGIR------VD 231
QK T+L QL+E+ + + +E+M + +
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367
Query: 232 QLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQ 291
L QLS +K+++ + E ++ +KE ++L E+ KLE+T +++Q
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427
Query: 292 --NETTAMKKQQELMDENFDLSKR-----LSENEIICNALQRQKERLEGE 334
++ Q + N + +R L+E + I + +++R E E
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1477
Score = 45.8 bits (107), Expect = 8e-05
Identities = 47/196 (23%), Positives = 87/196 (44%), Gaps = 21/196 (10%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELE-TLQSINKKLELKVK 199
++ E+E H +L ++ + + +KQ D+ EL+ + ELE TL S + EL+ K
Sbjct: 1112 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1171
Query: 200 EQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEM-EKLVQGDQDKTEQL 258
E E+ LK+ + + +E Q +EM +K Q ++ TEQL
Sbjct: 1172 R-----EQEVTVLKKALDEETRSHE--------------AQVQEMRQKHAQAVEELTEQL 1212
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENE 318
EQ K+ +L + K+ L + + Q + K+++L + +L + S+ E
Sbjct: 1213 EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1272
Query: 319 IICNALQRQKERLEGE 334
L + +L+ E
Sbjct: 1273 RARAELNDKVHKLQNE 1288
Score = 45.4 bits (106), Expect = 1e-04
Identities = 43/221 (19%), Positives = 102/221 (46%), Gaps = 24/221 (10%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ E E E L + +E ++ L++ N ++AE++ + + + + K + ++
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME---DLVSSKDDVGKNVH-EL 1530
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQG-DQDKTEQ 257
++ K ET++ ++K Q +++ E + +L+ + + + E+ +Q D+ E+
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 258 LEQLKKENDHLFLSLTEQRKD-------QKKLEQTVEQMKQNETTAMKKQQELMDENFDL 310
QL+++ L ++RK +KKLE ++ ++ +A+K ++E + + L
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 311 ------------SKRLSENEIICNALQRQKERLEGENDLLK 339
R S +EI A + +K+ E DL++
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Score = 42.0 bits (97), Expect = 0.001
Identities = 48/239 (20%), Positives = 103/239 (43%), Gaps = 35/239 (14%)
Query: 128 ENEEDILVVTTQGEVEE----IEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEE 183
E + + V T ++EE ++ E + Q L+ +L Q SD + +LQ
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386
Query: 184 LETLQSINKKLELKVKEQKDYWETELL---QLKEQNQKMSSENEKMGIRVDQLQAQLSTQ 240
+E L+ K+ + +++ +E + +L++ ++ E + + + +D + +S
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446
Query: 241 EKEMEKLVQ------------GDQDKTEQLEQLKKENDHLFLS--LTEQRKDQKKLEQTV 286
EK+ K Q D+ + E +KE L L+ L E + +++LE+T
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1506
Query: 287 EQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+ +K + ++L+ D+ K + E L++ K LE + + +K + L
Sbjct: 1507 KMLKA-------EMEDLVSSKDDVGKNVHE-------LEKSKRALETQMEEMKTQLEEL 1551
Score = 40.8 bits (94), Expect = 0.003
Identities = 38/196 (19%), Positives = 81/196 (41%), Gaps = 18/196 (9%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+G+++++E K +E LQ Q D Q EL+ + + + + K+ E K
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1682
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
K E +L+QL+E ++ + ++L +L++ L QD+ +L
Sbjct: 1683 KSL----EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL----QDEKRRL 1734
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENE 318
E + + ++ ++ + +E M A ++ ++L +E +NE
Sbjct: 1735 EA----------RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 319 IICNALQRQKERLEGE 334
L+RQ + L +
Sbjct: 1785 SARQQLERQNKELRSK 1800
Score = 38.9 bits (89), Expect = 0.010
Identities = 36/198 (18%), Positives = 98/198 (49%), Gaps = 15/198 (7%)
Query: 143 EEIEQHNKELCKEN---QELKDSCISLQKQNSDMQAELQKKQEELET-LQSINKKLELKV 198
++ EQ + EL E Q+ + + L++QN +++++L + + +++ +S LE K+
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1823
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
+ ++ E E + + + + +++K+ ++ Q+ + K E+ + + ++
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKL----KEILLQVEDERKMAEQYKEQAEKGNARV 1879
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQN------ETTAMKKQQELMDE-NFDLS 311
+QLK++ + +++KL++ +++ ++ E A+K + +E +F S
Sbjct: 1880 KQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPS 1939
Query: 312 KRLSENEIICNALQRQKE 329
+R +I NA ++E
Sbjct: 1940 RRSGGRRVIENADGSEEE 1957
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 67.0 bits (162), Expect = 3e-11
Identities = 50/235 (21%), Positives = 110/235 (46%), Gaps = 32/235 (13%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ E+E++ ++ K EL+ S +L+ Q +M+ +L++ ++EL+ + +LE+ +
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576
Query: 199 KEQKDYWETELLQLKEQNQK---------------MSSENEKMGIRV---DQLQAQLSTQ 240
+ K +E +L EQN++ + E ++ + +L+ L
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1636
Query: 241 EKEMEKLVQGDQDKTEQLEQLKKE--------------NDHLFLSLTEQRKDQKKLEQTV 286
E + + ++G ++ +QL +L+ + D +F + E K K LE +
Sbjct: 1637 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1696
Query: 287 EQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
Q++++ A + +++ E +L++ L+ + NALQ +K RLE L+ E
Sbjct: 1697 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Score = 61.6 bits (148), Expect = 1e-09
Identities = 57/227 (25%), Positives = 106/227 (46%), Gaps = 24/227 (10%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ +EE E ++L E +++ + L++Q + +A QK Q E T ++ KKLE ++
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 994
Query: 199 -----------KEQKDYWE------TELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQE 241
KE+K E T L + +E+ + ++ K + +L+ +L +E
Sbjct: 995 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1054
Query: 242 K---EMEKL---VQGD-QDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNET 294
K E+EKL ++GD D EQ+ L+ + L + L ++ ++ + ++ +
Sbjct: 1055 KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKN 1114
Query: 295 TAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
A+KK +EL DL + L N ++QK L E + LK E
Sbjct: 1115 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161
Score = 58.9 bits (141), Expect = 9e-09
Identities = 52/223 (23%), Positives = 110/223 (49%), Gaps = 27/223 (12%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
E + + V + +E+E+ E+ +E +D LQ + M ++ +E+LE ++
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 190 INKKLEL-------KVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEK 242
+KL+L K+K+ +D E+L + +QN K+S E + + R+ L L+ +E
Sbjct: 972 ARQKLQLEKVTAEAKIKKLED----EILVMDDQNNKLSKERKLLEERISDLTTNLAEEE- 1026
Query: 243 EMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQN-ETTAMKKQQ 301
+K + L +LK +++ + L + K ++K Q +E++K+ E A +
Sbjct: 1027 ----------EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076
Query: 302 ELMD---ENFDLSKRLS-ENEIICNALQRQKERLEGENDLLKR 340
++ D + +L +L+ + E + AL R + + +N+ LK+
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Score = 57.0 bits (136), Expect = 3e-08
Identities = 56/209 (26%), Positives = 102/209 (48%), Gaps = 31/209 (14%)
Query: 164 ISLQKQNSDMQA---ELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQ-KM 219
+ + +Q +MQA ELQK +E + ++ K+LE K + + E LLQ + Q + ++
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE--EKNLLQEQLQAETEL 909
Query: 220 SSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQ 279
+E E+M +R+ + +L EME ++ ++D+ +QL+ +K+ L L EQ +++
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 280 ------------------KKLEQTVEQMKQNETTAMKKQQELMDENF-DLSKRLSENEII 320
KKLE + M ++ + K+++L++E DL+ L+E E
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVM-DDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 321 CNALQRQKERLEG-----ENDLLKRENSR 344
L + K + E E L K E SR
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSR 1057
Score = 56.2 bits (134), Expect = 6e-08
Identities = 51/209 (24%), Positives = 101/209 (48%), Gaps = 30/209 (14%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSC---ISLQKQNSDMQAELQKKQEELETLQSINKKLE 195
+ E++E+EQ + +L +E L++ L + +M+ L K++ELE I ++E
Sbjct: 879 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE---EILHEME 935
Query: 196 LKVKEQKDYWET----------ELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEME 245
+++E++D + ++L L+EQ ++ + +K ++++++ A+ ++ E E
Sbjct: 936 ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK--LQLEKVTAEAKIKKLEDE 993
Query: 246 KLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMD 305
LV DQ+ +L KE L E+R E+ K T +K + E M
Sbjct: 994 ILVMDDQN-----NKLSKER-----KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043
Query: 306 ENFDLSKRLSENEIICNALQRQKERLEGE 334
+L RL + E L++ K +LEG+
Sbjct: 1044 S--ELEVRLKKEEKSRQELEKLKRKLEGD 1070
Score = 53.9 bits (128), Expect = 3e-07
Identities = 52/223 (23%), Positives = 105/223 (47%), Gaps = 21/223 (9%)
Query: 142 VEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQ 201
VEE+ + ++ + L + +L+K+N+D+ EL+ + + ++ KKLE +V+E
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 202 KDYWETELLQLKEQNQK-------------MSSENEKMGIRVDQLQAQLSTQEKEMEKLV 248
+ E N K M +E E I++ + A LS+Q ++ ++L+
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331
Query: 249 QGDQ----DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELM 304
Q + + + +L QL++E + L L E+ + ++ LE+ + + + + KK Q+
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391
Query: 305 D--ENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
E + K+ + EI L +Q E D L++ +RL
Sbjct: 1392 STVEALEEGKKRFQKEI--ENLTQQYEEKAAAYDKLEKTKNRL 1432
Score = 50.1 bits (118), Expect = 4e-06
Identities = 60/239 (25%), Positives = 108/239 (45%), Gaps = 33/239 (13%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEEL--ETLQSINKKLELK- 197
+V +++ + + E + I L K + + ++LQ QE L ET Q +N +L+
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 198 VKEQKDYWETELLQLKEQNQKMSSENEKMGIRVD----QLQAQLSTQE----------KE 243
++E+++ + +L + E Q + + I++ +LQ ST E KE
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 244 MEKLVQGDQDKTEQLEQLKK-------ENDHLFLSLTEQR-------KDQKKLEQTVEQM 289
+E L Q ++K ++L+K E D L + L QR K Q+K +Q + +
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1467
Query: 290 KQ-NETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLS 347
K + A ++ + + +K LS + AL+ KE LE N +LK E L+S
Sbjct: 1468 KNISSKYADERDRAEAEAREKETKALSLARALEEALE-AKEELERTNKMLKAEMEDLVS 1525
Score = 49.3 bits (116), Expect = 7e-06
Identities = 59/256 (23%), Positives = 106/256 (41%), Gaps = 43/256 (16%)
Query: 130 EEDILVVTTQGEV---------EEIEQHNKELCKENQELKDSCISLQKQNS---DMQAEL 177
E++ILV+ Q E I L +E ++ K+ K S +++ L
Sbjct: 991 EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1050
Query: 178 QKKQEELETLQSINKKLELKVK---EQKDYWETELLQLKEQNQKMSSENEKMGIRVD--- 231
+K+++ + L+ + +KLE EQ + ++ +LK Q K E + R+D
Sbjct: 1051 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1110
Query: 232 ------------------QLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLT 273
LQ L ++ K + +D E+LE LK E + S
Sbjct: 1111 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170
Query: 274 EQRKDQKKLEQTVEQMKQ---NETTAMKKQ-QELMDENFDLSKRLSENEIICNALQRQKE 329
Q++ + K EQ V +K+ ET + + Q QE+ ++ + L+E +R K
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ---LEQFKRAKA 1227
Query: 330 RLEGENDLLKRENSRL 345
L+ L++EN+ L
Sbjct: 1228 NLDKNKQTLEKENADL 1243
Score = 49.3 bits (116), Expect = 7e-06
Identities = 33/165 (20%), Positives = 74/165 (44%), Gaps = 11/165 (6%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
Q ++++ ++ ++ E+ + +K+ ++A+L + QE+L + K+ +L+
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
+E + EL + E ++ R+ QL+ +L ++ ME + + T+Q
Sbjct: 1718 EELAE----ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQEL 303
EQL E L +R +K E +Q+++ K E+
Sbjct: 1774 EQLSNE-------LATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Score = 47.0 bits (110), Expect = 4e-05
Identities = 47/230 (20%), Positives = 99/230 (43%), Gaps = 38/230 (16%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV---- 198
+E+E K+L + QEL+ C ++ +++ ++ K Q E+E++ + + E K
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314
Query: 199 --------------------KEQKDYWETELLQLKEQNQKMSSE-NEKMGIR------VD 231
QK T+L QL+E+ + + +E+M + +
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374
Query: 232 QLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQ 291
L QLS +K+++ + E ++ +KE ++L E+ KLE+T +++Q
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434
Query: 292 --NETTAMKKQQELMDENFDLSKR-----LSENEIICNALQRQKERLEGE 334
++ Q + N + +R L+E + I + +++R E E
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484
Score = 45.8 bits (107), Expect = 8e-05
Identities = 47/196 (23%), Positives = 87/196 (44%), Gaps = 21/196 (10%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELE-TLQSINKKLELKVK 199
++ E+E H +L ++ + + +KQ D+ EL+ + ELE TL S + EL+ K
Sbjct: 1119 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1178
Query: 200 EQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEM-EKLVQGDQDKTEQL 258
E E+ LK+ + + +E Q +EM +K Q ++ TEQL
Sbjct: 1179 R-----EQEVTVLKKALDEETRSHE--------------AQVQEMRQKHAQAVEELTEQL 1219
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENE 318
EQ K+ +L + K+ L + + Q + K+++L + +L + S+ E
Sbjct: 1220 EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279
Query: 319 IICNALQRQKERLEGE 334
L + +L+ E
Sbjct: 1280 RARAELNDKVHKLQNE 1295
Score = 45.4 bits (106), Expect = 1e-04
Identities = 43/221 (19%), Positives = 102/221 (46%), Gaps = 24/221 (10%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ E E E L + +E ++ L++ N ++AE++ + + + + K + ++
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME---DLVSSKDDVGKNVH-EL 1537
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQG-DQDKTEQ 257
++ K ET++ ++K Q +++ E + +L+ + + + E+ +Q D+ E+
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 258 LEQLKKENDHLFLSLTEQRKD-------QKKLEQTVEQMKQNETTAMKKQQELMDENFDL 310
QL+++ L ++RK +KKLE ++ ++ +A+K ++E + + L
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 311 ------------SKRLSENEIICNALQRQKERLEGENDLLK 339
R S +EI A + +K+ E DL++
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Score = 42.0 bits (97), Expect = 0.001
Identities = 48/239 (20%), Positives = 103/239 (43%), Gaps = 35/239 (14%)
Query: 128 ENEEDILVVTTQGEVEE----IEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEE 183
E + + V T ++EE ++ E + Q L+ +L Q SD + +LQ
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393
Query: 184 LETLQSINKKLELKVKEQKDYWETELL---QLKEQNQKMSSENEKMGIRVDQLQAQLSTQ 240
+E L+ K+ + +++ +E + +L++ ++ E + + + +D + +S
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453
Query: 241 EKEMEKLVQ------------GDQDKTEQLEQLKKENDHLFLS--LTEQRKDQKKLEQTV 286
EK+ K Q D+ + E +KE L L+ L E + +++LE+T
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1513
Query: 287 EQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+ +K + ++L+ D+ K + E L++ K LE + + +K + L
Sbjct: 1514 KMLKA-------EMEDLVSSKDDVGKNVHE-------LEKSKRALETQMEEMKTQLEEL 1558
Score = 40.8 bits (94), Expect = 0.003
Identities = 38/196 (19%), Positives = 81/196 (41%), Gaps = 18/196 (9%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+G+++++E K +E LQ Q D Q EL+ + + + + K+ E K
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1689
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
K E +L+QL+E ++ + ++L +L++ L QD+ +L
Sbjct: 1690 KSL----EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL----QDEKRRL 1741
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENE 318
E + + ++ ++ + +E M A ++ ++L +E +NE
Sbjct: 1742 EA----------RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 319 IICNALQRQKERLEGE 334
L+RQ + L +
Sbjct: 1792 SARQQLERQNKELRSK 1807
Score = 38.9 bits (89), Expect = 0.010
Identities = 36/198 (18%), Positives = 98/198 (49%), Gaps = 15/198 (7%)
Query: 143 EEIEQHNKELCKEN---QELKDSCISLQKQNSDMQAELQKKQEELET-LQSINKKLELKV 198
++ EQ + EL E Q+ + + L++QN +++++L + + +++ +S LE K+
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1830
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
+ ++ E E + + + + +++K+ ++ Q+ + K E+ + + ++
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKL----KEILLQVEDERKMAEQYKEQAEKGNARV 1886
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQN------ETTAMKKQQELMDE-NFDLS 311
+QLK++ + +++KL++ +++ ++ E A+K + +E +F S
Sbjct: 1887 KQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPS 1946
Query: 312 KRLSENEIICNALQRQKE 329
+R +I NA ++E
Sbjct: 1947 RRSGGRRVIENADGSEEE 1964
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 67.0 bits (162), Expect = 3e-11
Identities = 50/235 (21%), Positives = 110/235 (46%), Gaps = 32/235 (13%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ E+E++ ++ K EL+ S +L+ Q +M+ +L++ ++EL+ + +LE+ +
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576
Query: 199 KEQKDYWETELLQLKEQNQK---------------MSSENEKMGIRV---DQLQAQLSTQ 240
+ K +E +L EQN++ + E ++ + +L+ L
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1636
Query: 241 EKEMEKLVQGDQDKTEQLEQLKKE--------------NDHLFLSLTEQRKDQKKLEQTV 286
E + + ++G ++ +QL +L+ + D +F + E K K LE +
Sbjct: 1637 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1696
Query: 287 EQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
Q++++ A + +++ E +L++ L+ + NALQ +K RLE L+ E
Sbjct: 1697 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Score = 61.6 bits (148), Expect = 1e-09
Identities = 57/227 (25%), Positives = 106/227 (46%), Gaps = 24/227 (10%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ +EE E ++L E +++ + L++Q + +A QK Q E T ++ KKLE ++
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 994
Query: 199 -----------KEQKDYWE------TELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQE 241
KE+K E T L + +E+ + ++ K + +L+ +L +E
Sbjct: 995 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1054
Query: 242 K---EMEKL---VQGD-QDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNET 294
K E+EKL ++GD D EQ+ L+ + L + L ++ ++ + ++ +
Sbjct: 1055 KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKN 1114
Query: 295 TAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
A+KK +EL DL + L N ++QK L E + LK E
Sbjct: 1115 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161
Score = 58.9 bits (141), Expect = 9e-09
Identities = 52/223 (23%), Positives = 110/223 (49%), Gaps = 27/223 (12%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
E + + V + +E+E+ E+ +E +D LQ + M ++ +E+LE ++
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 190 INKKLEL-------KVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEK 242
+KL+L K+K+ +D E+L + +QN K+S E + + R+ L L+ +E
Sbjct: 972 ARQKLQLEKVTAEAKIKKLED----EILVMDDQNNKLSKERKLLEERISDLTTNLAEEE- 1026
Query: 243 EMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQN-ETTAMKKQQ 301
+K + L +LK +++ + L + K ++K Q +E++K+ E A +
Sbjct: 1027 ----------EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076
Query: 302 ELMD---ENFDLSKRLS-ENEIICNALQRQKERLEGENDLLKR 340
++ D + +L +L+ + E + AL R + + +N+ LK+
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Score = 57.0 bits (136), Expect = 3e-08
Identities = 56/209 (26%), Positives = 102/209 (48%), Gaps = 31/209 (14%)
Query: 164 ISLQKQNSDMQA---ELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQ-KM 219
+ + +Q +MQA ELQK +E + ++ K+LE K + + E LLQ + Q + ++
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE--EKNLLQEQLQAETEL 909
Query: 220 SSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQ 279
+E E+M +R+ + +L EME ++ ++D+ +QL+ +K+ L L EQ +++
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 280 ------------------KKLEQTVEQMKQNETTAMKKQQELMDENF-DLSKRLSENEII 320
KKLE + M ++ + K+++L++E DL+ L+E E
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVM-DDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 321 CNALQRQKERLEG-----ENDLLKRENSR 344
L + K + E E L K E SR
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSR 1057
Score = 56.2 bits (134), Expect = 6e-08
Identities = 51/209 (24%), Positives = 101/209 (48%), Gaps = 30/209 (14%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSC---ISLQKQNSDMQAELQKKQEELETLQSINKKLE 195
+ E++E+EQ + +L +E L++ L + +M+ L K++ELE I ++E
Sbjct: 879 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE---EILHEME 935
Query: 196 LKVKEQKDYWET----------ELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEME 245
+++E++D + ++L L+EQ ++ + +K ++++++ A+ ++ E E
Sbjct: 936 ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK--LQLEKVTAEAKIKKLEDE 993
Query: 246 KLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMD 305
LV DQ+ +L KE L E+R E+ K T +K + E M
Sbjct: 994 ILVMDDQN-----NKLSKER-----KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043
Query: 306 ENFDLSKRLSENEIICNALQRQKERLEGE 334
+L RL + E L++ K +LEG+
Sbjct: 1044 S--ELEVRLKKEEKSRQELEKLKRKLEGD 1070
Score = 53.9 bits (128), Expect = 3e-07
Identities = 52/223 (23%), Positives = 105/223 (47%), Gaps = 21/223 (9%)
Query: 142 VEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQ 201
VEE+ + ++ + L + +L+K+N+D+ EL+ + + ++ KKLE +V+E
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 202 KDYWETELLQLKEQNQK-------------MSSENEKMGIRVDQLQAQLSTQEKEMEKLV 248
+ E N K M +E E I++ + A LS+Q ++ ++L+
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331
Query: 249 QGDQ----DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELM 304
Q + + + +L QL++E + L L E+ + ++ LE+ + + + + KK Q+
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391
Query: 305 D--ENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
E + K+ + EI L +Q E D L++ +RL
Sbjct: 1392 STVEALEEGKKRFQKEI--ENLTQQYEEKAAAYDKLEKTKNRL 1432
Score = 50.1 bits (118), Expect = 4e-06
Identities = 60/239 (25%), Positives = 108/239 (45%), Gaps = 33/239 (13%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEEL--ETLQSINKKLELK- 197
+V +++ + + E + I L K + + ++LQ QE L ET Q +N +L+
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 198 VKEQKDYWETELLQLKEQNQKMSSENEKMGIRVD----QLQAQLSTQE----------KE 243
++E+++ + +L + E Q + + I++ +LQ ST E KE
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 244 MEKLVQGDQDKTEQLEQLKK-------ENDHLFLSLTEQR-------KDQKKLEQTVEQM 289
+E L Q ++K ++L+K E D L + L QR K Q+K +Q + +
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1467
Query: 290 KQ-NETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLS 347
K + A ++ + + +K LS + AL+ KE LE N +LK E L+S
Sbjct: 1468 KNISSKYADERDRAEAEAREKETKALSLARALEEALE-AKEELERTNKMLKAEMEDLVS 1525
Score = 49.3 bits (116), Expect = 7e-06
Identities = 59/256 (23%), Positives = 106/256 (41%), Gaps = 43/256 (16%)
Query: 130 EEDILVVTTQGEV---------EEIEQHNKELCKENQELKDSCISLQKQNS---DMQAEL 177
E++ILV+ Q E I L +E ++ K+ K S +++ L
Sbjct: 991 EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1050
Query: 178 QKKQEELETLQSINKKLELKVK---EQKDYWETELLQLKEQNQKMSSENEKMGIRVD--- 231
+K+++ + L+ + +KLE EQ + ++ +LK Q K E + R+D
Sbjct: 1051 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1110
Query: 232 ------------------QLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLT 273
LQ L ++ K + +D E+LE LK E + S
Sbjct: 1111 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170
Query: 274 EQRKDQKKLEQTVEQMKQ---NETTAMKKQ-QELMDENFDLSKRLSENEIICNALQRQKE 329
Q++ + K EQ V +K+ ET + + Q QE+ ++ + L+E +R K
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ---LEQFKRAKA 1227
Query: 330 RLEGENDLLKRENSRL 345
L+ L++EN+ L
Sbjct: 1228 NLDKNKQTLEKENADL 1243
Score = 49.3 bits (116), Expect = 7e-06
Identities = 33/165 (20%), Positives = 74/165 (44%), Gaps = 11/165 (6%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
Q ++++ ++ ++ E+ + +K+ ++A+L + QE+L + K+ +L+
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
+E + EL + E ++ R+ QL+ +L ++ ME + + T+Q
Sbjct: 1718 EELAE----ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQEL 303
EQL E L +R +K E +Q+++ K E+
Sbjct: 1774 EQLSNE-------LATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Score = 47.0 bits (110), Expect = 4e-05
Identities = 47/230 (20%), Positives = 99/230 (43%), Gaps = 38/230 (16%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV---- 198
+E+E K+L + QEL+ C ++ +++ ++ K Q E+E++ + + E K
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314
Query: 199 --------------------KEQKDYWETELLQLKEQNQKMSSE-NEKMGIR------VD 231
QK T+L QL+E+ + + +E+M + +
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374
Query: 232 QLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQ 291
L QLS +K+++ + E ++ +KE ++L E+ KLE+T +++Q
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434
Query: 292 --NETTAMKKQQELMDENFDLSKR-----LSENEIICNALQRQKERLEGE 334
++ Q + N + +R L+E + I + +++R E E
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484
Score = 45.8 bits (107), Expect = 8e-05
Identities = 47/196 (23%), Positives = 87/196 (44%), Gaps = 21/196 (10%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELE-TLQSINKKLELKVK 199
++ E+E H +L ++ + + +KQ D+ EL+ + ELE TL S + EL+ K
Sbjct: 1119 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1178
Query: 200 EQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEM-EKLVQGDQDKTEQL 258
E E+ LK+ + + +E Q +EM +K Q ++ TEQL
Sbjct: 1179 R-----EQEVTVLKKALDEETRSHE--------------AQVQEMRQKHAQAVEELTEQL 1219
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENE 318
EQ K+ +L + K+ L + + Q + K+++L + +L + S+ E
Sbjct: 1220 EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279
Query: 319 IICNALQRQKERLEGE 334
L + +L+ E
Sbjct: 1280 RARAELNDKVHKLQNE 1295
Score = 45.4 bits (106), Expect = 1e-04
Identities = 43/221 (19%), Positives = 102/221 (46%), Gaps = 24/221 (10%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ E E E L + +E ++ L++ N ++AE++ + + + + K + ++
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME---DLVSSKDDVGKNVH-EL 1537
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQG-DQDKTEQ 257
++ K ET++ ++K Q +++ E + +L+ + + + E+ +Q D+ E+
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 258 LEQLKKENDHLFLSLTEQRKD-------QKKLEQTVEQMKQNETTAMKKQQELMDENFDL 310
QL+++ L ++RK +KKLE ++ ++ +A+K ++E + + L
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 311 ------------SKRLSENEIICNALQRQKERLEGENDLLK 339
R S +EI A + +K+ E DL++
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Score = 42.0 bits (97), Expect = 0.001
Identities = 48/239 (20%), Positives = 103/239 (43%), Gaps = 35/239 (14%)
Query: 128 ENEEDILVVTTQGEVEE----IEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEE 183
E + + V T ++EE ++ E + Q L+ +L Q SD + +LQ
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393
Query: 184 LETLQSINKKLELKVKEQKDYWETELL---QLKEQNQKMSSENEKMGIRVDQLQAQLSTQ 240
+E L+ K+ + +++ +E + +L++ ++ E + + + +D + +S
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453
Query: 241 EKEMEKLVQ------------GDQDKTEQLEQLKKENDHLFLS--LTEQRKDQKKLEQTV 286
EK+ K Q D+ + E +KE L L+ L E + +++LE+T
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1513
Query: 287 EQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+ +K + ++L+ D+ K + E L++ K LE + + +K + L
Sbjct: 1514 KMLKA-------EMEDLVSSKDDVGKNVHE-------LEKSKRALETQMEEMKTQLEEL 1558
Score = 40.8 bits (94), Expect = 0.003
Identities = 38/196 (19%), Positives = 81/196 (41%), Gaps = 18/196 (9%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+G+++++E K +E LQ Q D Q EL+ + + + + K+ E K
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1689
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
K E +L+QL+E ++ + ++L +L++ L QD+ +L
Sbjct: 1690 KSL----EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL----QDEKRRL 1741
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENE 318
E + + ++ ++ + +E M A ++ ++L +E +NE
Sbjct: 1742 EA----------RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 319 IICNALQRQKERLEGE 334
L+RQ + L +
Sbjct: 1792 SARQQLERQNKELRSK 1807
Score = 35.4 bits (80), Expect = 0.11
Identities = 25/154 (16%), Positives = 79/154 (51%), Gaps = 8/154 (5%)
Query: 143 EEIEQHNKELCKEN---QELKDSCISLQKQNSDMQAELQKKQEELET-LQSINKKLELKV 198
++ EQ + EL E Q+ + + L++QN +++++L + + +++ +S LE K+
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1830
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
+ ++ E E + + + + +++K+ ++ Q+ + K E+ + + ++
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKL----KEILLQVEDERKMAEQYKEQAEKGNARV 1886
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQN 292
+QLK++ + +++KL++ +++ ++
Sbjct: 1887 KQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Score = 32.0 bits (71), Expect = 1.2
Identities = 27/130 (20%), Positives = 57/130 (43%), Gaps = 25/130 (19%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQN------------SDMQAELQKKQEELETLQSI 190
+++E+ NKEL + E++ + S K ++ E ++KQ ++L+
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Query: 191 NKKLEL-------------KVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQL 237
+KKL+ + KEQ + + QLK Q ++ E++++ +LQ +L
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Query: 238 STQEKEMEKL 247
+ E +
Sbjct: 1915 DEATESNEAM 1924
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 67.0 bits (162), Expect = 3e-11
Identities = 50/235 (21%), Positives = 110/235 (46%), Gaps = 32/235 (13%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ E+E++ ++ K EL+ S +L+ Q +M+ +L++ ++EL+ + +LE+ +
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1569
Query: 199 KEQKDYWETELLQLKEQNQK---------------MSSENEKMGIRV---DQLQAQLSTQ 240
+ K +E +L EQN++ + E ++ + +L+ L
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1629
Query: 241 EKEMEKLVQGDQDKTEQLEQLKKE--------------NDHLFLSLTEQRKDQKKLEQTV 286
E + + ++G ++ +QL +L+ + D +F + E K K LE +
Sbjct: 1630 ELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1689
Query: 287 EQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
Q++++ A + +++ E +L++ L+ + NALQ +K RLE L+ E
Sbjct: 1690 MQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Score = 61.6 bits (148), Expect = 1e-09
Identities = 57/227 (25%), Positives = 106/227 (46%), Gaps = 24/227 (10%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ +EE E ++L E +++ + L++Q + +A QK Q E T ++ KKLE ++
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 987
Query: 199 -----------KEQKDYWE------TELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQE 241
KE+K E T L + +E+ + ++ K + +L+ +L +E
Sbjct: 988 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1047
Query: 242 K---EMEKL---VQGD-QDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNET 294
K E+EKL ++GD D EQ+ L+ + L + L ++ ++ + ++ +
Sbjct: 1048 KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKN 1107
Query: 295 TAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
A+KK +EL DL + L N ++QK L E + LK E
Sbjct: 1108 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154
Score = 58.9 bits (141), Expect = 9e-09
Identities = 52/223 (23%), Positives = 110/223 (49%), Gaps = 27/223 (12%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
E + + V + +E+E+ E+ +E +D LQ + M ++ +E+LE ++
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 190 INKKLEL-------KVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEK 242
+KL+L K+K+ +D E+L + +QN K+S E + + R+ L L+ +E
Sbjct: 965 ARQKLQLEKVTAEAKIKKLED----EILVMDDQNNKLSKERKLLEERISDLTTNLAEEE- 1019
Query: 243 EMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQN-ETTAMKKQQ 301
+K + L +LK +++ + L + K ++K Q +E++K+ E A +
Sbjct: 1020 ----------EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069
Query: 302 ELMD---ENFDLSKRLS-ENEIICNALQRQKERLEGENDLLKR 340
++ D + +L +L+ + E + AL R + + +N+ LK+
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Score = 57.0 bits (136), Expect = 3e-08
Identities = 56/209 (26%), Positives = 102/209 (48%), Gaps = 31/209 (14%)
Query: 164 ISLQKQNSDMQA---ELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQ-KM 219
+ + +Q +MQA ELQK +E + ++ K+LE K + + E LLQ + Q + ++
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE--EKNLLQEQLQAETEL 902
Query: 220 SSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQ 279
+E E+M +R+ + +L EME ++ ++D+ +QL+ +K+ L L EQ +++
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 280 ------------------KKLEQTVEQMKQNETTAMKKQQELMDENF-DLSKRLSENEII 320
KKLE + M ++ + K+++L++E DL+ L+E E
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVM-DDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 321 CNALQRQKERLEG-----ENDLLKRENSR 344
L + K + E E L K E SR
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSR 1050
Score = 56.2 bits (134), Expect = 6e-08
Identities = 51/209 (24%), Positives = 101/209 (48%), Gaps = 30/209 (14%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSC---ISLQKQNSDMQAELQKKQEELETLQSINKKLE 195
+ E++E+EQ + +L +E L++ L + +M+ L K++ELE I ++E
Sbjct: 872 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELE---EILHEME 928
Query: 196 LKVKEQKDYWET----------ELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEME 245
+++E++D + ++L L+EQ ++ + +K ++++++ A+ ++ E E
Sbjct: 929 ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK--LQLEKVTAEAKIKKLEDE 986
Query: 246 KLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMD 305
LV DQ+ +L KE L E+R E+ K T +K + E M
Sbjct: 987 ILVMDDQN-----NKLSKER-----KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036
Query: 306 ENFDLSKRLSENEIICNALQRQKERLEGE 334
+L RL + E L++ K +LEG+
Sbjct: 1037 S--ELEVRLKKEEKSRQELEKLKRKLEGD 1063
Score = 53.9 bits (128), Expect = 3e-07
Identities = 52/223 (23%), Positives = 105/223 (47%), Gaps = 21/223 (9%)
Query: 142 VEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQ 201
VEE+ + ++ + L + +L+K+N+D+ EL+ + + ++ KKLE +V+E
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 202 KDYWETELLQLKEQNQK-------------MSSENEKMGIRVDQLQAQLSTQEKEMEKLV 248
+ E N K M +E E I++ + A LS+Q ++ ++L+
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324
Query: 249 QGDQ----DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELM 304
Q + + + +L QL++E + L L E+ + ++ LE+ + + + + KK Q+
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384
Query: 305 D--ENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
E + K+ + EI L +Q E D L++ +RL
Sbjct: 1385 STVEALEEGKKRFQKEI--ENLTQQYEEKAAAYDKLEKTKNRL 1425
Score = 50.1 bits (118), Expect = 4e-06
Identities = 60/239 (25%), Positives = 108/239 (45%), Gaps = 33/239 (13%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEEL--ETLQSINKKLELK- 197
+V +++ + + E + I L K + + ++LQ QE L ET Q +N +L+
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 198 VKEQKDYWETELLQLKEQNQKMSSENEKMGIRVD----QLQAQLSTQE----------KE 243
++E+++ + +L + E Q + + I++ +LQ ST E KE
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 244 MEKLVQGDQDKTEQLEQLKK-------ENDHLFLSLTEQR-------KDQKKLEQTVEQM 289
+E L Q ++K ++L+K E D L + L QR K Q+K +Q + +
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460
Query: 290 KQ-NETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLS 347
K + A ++ + + +K LS + AL+ KE LE N +LK E L+S
Sbjct: 1461 KNISSKYADERDRAEAEAREKETKALSLARALEEALE-AKEELERTNKMLKAEMEDLVS 1518
Score = 49.3 bits (116), Expect = 7e-06
Identities = 59/256 (23%), Positives = 106/256 (41%), Gaps = 43/256 (16%)
Query: 130 EEDILVVTTQGEV---------EEIEQHNKELCKENQELKDSCISLQKQNS---DMQAEL 177
E++ILV+ Q E I L +E ++ K+ K S +++ L
Sbjct: 984 EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1043
Query: 178 QKKQEELETLQSINKKLELKVK---EQKDYWETELLQLKEQNQKMSSENEKMGIRVD--- 231
+K+++ + L+ + +KLE EQ + ++ +LK Q K E + R+D
Sbjct: 1044 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1103
Query: 232 ------------------QLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLT 273
LQ L ++ K + +D E+LE LK E + S
Sbjct: 1104 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1163
Query: 274 EQRKDQKKLEQTVEQMKQ---NETTAMKKQ-QELMDENFDLSKRLSENEIICNALQRQKE 329
Q++ + K EQ V +K+ ET + + Q QE+ ++ + L+E +R K
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ---LEQFKRAKA 1220
Query: 330 RLEGENDLLKRENSRL 345
L+ L++EN+ L
Sbjct: 1221 NLDKNKQTLEKENADL 1236
Score = 49.3 bits (116), Expect = 7e-06
Identities = 33/165 (20%), Positives = 74/165 (44%), Gaps = 11/165 (6%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
Q ++++ ++ ++ E+ + +K+ ++A+L + QE+L + K+ +L+
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
+E + EL + E ++ R+ QL+ +L ++ ME + + T+Q
Sbjct: 1711 EELAE----ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQEL 303
EQL E L +R +K E +Q+++ K E+
Sbjct: 1767 EQLSNE-------LATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Score = 47.0 bits (110), Expect = 4e-05
Identities = 47/230 (20%), Positives = 99/230 (43%), Gaps = 38/230 (16%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV---- 198
+E+E K+L + QEL+ C ++ +++ ++ K Q E+E++ + + E K
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307
Query: 199 --------------------KEQKDYWETELLQLKEQNQKMSSE-NEKMGIR------VD 231
QK T+L QL+E+ + + +E+M + +
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367
Query: 232 QLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQ 291
L QLS +K+++ + E ++ +KE ++L E+ KLE+T +++Q
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427
Query: 292 --NETTAMKKQQELMDENFDLSKR-----LSENEIICNALQRQKERLEGE 334
++ Q + N + +R L+E + I + +++R E E
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1477
Score = 45.8 bits (107), Expect = 8e-05
Identities = 47/196 (23%), Positives = 87/196 (44%), Gaps = 21/196 (10%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELE-TLQSINKKLELKVK 199
++ E+E H +L ++ + + +KQ D+ EL+ + ELE TL S + EL+ K
Sbjct: 1112 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1171
Query: 200 EQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEM-EKLVQGDQDKTEQL 258
E E+ LK+ + + +E Q +EM +K Q ++ TEQL
Sbjct: 1172 R-----EQEVTVLKKALDEETRSHE--------------AQVQEMRQKHAQAVEELTEQL 1212
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENE 318
EQ K+ +L + K+ L + + Q + K+++L + +L + S+ E
Sbjct: 1213 EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1272
Query: 319 IICNALQRQKERLEGE 334
L + +L+ E
Sbjct: 1273 RARAELNDKVHKLQNE 1288
Score = 45.4 bits (106), Expect = 1e-04
Identities = 43/221 (19%), Positives = 102/221 (46%), Gaps = 24/221 (10%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+ E E E L + +E ++ L++ N ++AE++ + + + + K + ++
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME---DLVSSKDDVGKNVH-EL 1530
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQG-DQDKTEQ 257
++ K ET++ ++K Q +++ E + +L+ + + + E+ +Q D+ E+
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 258 LEQLKKENDHLFLSLTEQRKD-------QKKLEQTVEQMKQNETTAMKKQQELMDENFDL 310
QL+++ L ++RK +KKLE ++ ++ +A+K ++E + + L
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 311 ------------SKRLSENEIICNALQRQKERLEGENDLLK 339
R S +EI A + +K+ E DL++
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Score = 42.0 bits (97), Expect = 0.001
Identities = 48/239 (20%), Positives = 103/239 (43%), Gaps = 35/239 (14%)
Query: 128 ENEEDILVVTTQGEVEE----IEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEE 183
E + + V T ++EE ++ E + Q L+ +L Q SD + +LQ
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386
Query: 184 LETLQSINKKLELKVKEQKDYWETELL---QLKEQNQKMSSENEKMGIRVDQLQAQLSTQ 240
+E L+ K+ + +++ +E + +L++ ++ E + + + +D + +S
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446
Query: 241 EKEMEKLVQ------------GDQDKTEQLEQLKKENDHLFLS--LTEQRKDQKKLEQTV 286
EK+ K Q D+ + E +KE L L+ L E + +++LE+T
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1506
Query: 287 EQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+ +K + ++L+ D+ K + E L++ K LE + + +K + L
Sbjct: 1507 KMLKA-------EMEDLVSSKDDVGKNVHE-------LEKSKRALETQMEEMKTQLEEL 1551
Score = 40.8 bits (94), Expect = 0.003
Identities = 38/196 (19%), Positives = 81/196 (41%), Gaps = 18/196 (9%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+G+++++E K +E LQ Q D Q EL+ + + + + K+ E K
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA 1682
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
K E +L+QL+E ++ + ++L +L++ L QD+ +L
Sbjct: 1683 KSL----EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL----QDEKRRL 1734
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENE 318
E + + ++ ++ + +E M A ++ ++L +E +NE
Sbjct: 1735 EA----------RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 319 IICNALQRQKERLEGE 334
L+RQ + L +
Sbjct: 1785 SARQQLERQNKELRSK 1800
Score = 35.4 bits (80), Expect = 0.11
Identities = 25/154 (16%), Positives = 79/154 (51%), Gaps = 8/154 (5%)
Query: 143 EEIEQHNKELCKEN---QELKDSCISLQKQNSDMQAELQKKQEELET-LQSINKKLELKV 198
++ EQ + EL E Q+ + + L++QN +++++L + + +++ +S LE K+
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1823
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
+ ++ E E + + + + +++K+ ++ Q+ + K E+ + + ++
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKL----KEILLQVEDERKMAEQYKEQAEKGNARV 1879
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQN 292
+QLK++ + +++KL++ +++ ++
Sbjct: 1880 KQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Score = 32.0 bits (71), Expect = 1.2
Identities = 27/130 (20%), Positives = 57/130 (43%), Gaps = 25/130 (19%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQN------------SDMQAELQKKQEELETLQSI 190
+++E+ NKEL + E++ + S K ++ E ++KQ ++L+
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847
Query: 191 NKKLEL-------------KVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQL 237
+KKL+ + KEQ + + QLK Q ++ E++++ +LQ +L
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Query: 238 STQEKEMEKL 247
+ E +
Sbjct: 1908 DEATESNEAM 1917
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 65.9 bits (159), Expect = 7e-11
Identities = 54/210 (25%), Positives = 99/210 (47%), Gaps = 13/210 (6%)
Query: 149 NKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSIN----------KKLELKV 198
+KE E +KD I L++ N+ +QAE Q +E+L+ L++ N +K +
Sbjct: 1045 HKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFL 1104
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
+E +T+ +L+ +N +SS++ + + LQ + +E E E L + + T
Sbjct: 1105 QEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAY 1164
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENE 318
E L ++++HL Q + + L + +K + +EL + + D+ KR +E E
Sbjct: 1165 EALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELE 1224
Query: 319 IICNALQRQKERLEGE---NDLLKRENSRL 345
L ++E L+ E N L EN RL
Sbjct: 1225 EREKVLTTEREALQQEQRTNALAMGENQRL 1254
Score = 55.1 bits (131), Expect = 1e-07
Identities = 51/229 (22%), Positives = 102/229 (44%), Gaps = 28/229 (12%)
Query: 136 VTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQE----------ELE 185
V+++ ++++E+ NK L + E L+ + + +L++ +E EL+
Sbjct: 579 VSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQ 638
Query: 186 TLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQ----------- 234
LQ N +L KV + E ++ L+ ++Q + EN + +D LQ
Sbjct: 639 RLQEENGRLARKVTSLETATE-KVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLER 697
Query: 235 --AQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQN 292
QL + E+ +LV+ + + +L Q+++EN L E RK+ L+ ++ ++
Sbjct: 698 DNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERL 757
Query: 293 ETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
E + Q + EN L + L + L+ + LE E L+R+
Sbjct: 758 ELS----YQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRD 802
Score = 50.4 bits (119), Expect = 3e-06
Identities = 54/228 (23%), Positives = 106/228 (46%), Gaps = 45/228 (19%)
Query: 144 EIEQHNKELCKENQELKDSCISLQKQNSDMQA-------ELQKKQEELETLQSINKKLEL 196
E+E+ N +L K+ ++L+ ++ N D++ E ++ Q ++ETL++ +
Sbjct: 498 ELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIK 557
Query: 197 KVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTE 256
++++KD+ + L+E++Q S +A++ EKE + L Q +
Sbjct: 558 DLEQEKDHLNRAMWSLRERSQVSS-------------EARMKDVEKENKALHQTVTEANG 604
Query: 257 QLEQLKKENDHLFLSLTEQRKDQ----KKLEQTVEQMKQN-----------ETTAMK--- 298
+L QL+ E L L EQ K++ +KLE+ ++++++ ET K
Sbjct: 605 KLSQLEFEKRQLHRDL-EQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEA 663
Query: 299 ---KQQELMDENFDLSKRLSENEII---CNALQRQKERLEGENDLLKR 340
+ Q L EN L K L + + L+R ++L+ EN L+R
Sbjct: 664 LEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRR 711
Score = 50.4 bits (119), Expect = 3e-06
Identities = 53/215 (24%), Positives = 103/215 (47%), Gaps = 25/215 (11%)
Query: 143 EEIEQHNKELCKENQELKDSCIS-------LQKQNSDMQAELQKKQEELETLQSINKKLE 195
E +E + + EN L+ S S L+ + +++AE Q + +LE L+ N +LE
Sbjct: 755 ERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLE 814
Query: 196 LKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRV-------DQLQAQLSTQEKE---ME 245
K++K E E+ QL++ + + E +++ +V D A+LS EKE ++
Sbjct: 815 GAEKDRKAL-EQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALD 873
Query: 246 KLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQ--TVEQMKQNETTAM--KKQQ 301
K + +D +L++L+K+N L +T + L + +E++K + ++ K Q
Sbjct: 874 KELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQ 933
Query: 302 ELMDENFDLSKRLSENEIICNALQRQKERLEGEND 336
EL + L E++ + + + LEG N+
Sbjct: 934 ELEKVGLNRELLLQEDD---SGSDTKYKILEGRNE 965
Score = 48.1 bits (113), Expect = 2e-05
Identities = 63/246 (25%), Positives = 108/246 (43%), Gaps = 31/246 (12%)
Query: 126 RPENEEDILVVTTQGEVEEIEQHNKELCK-ENQELK---DSCISLQKQNSDMQAELQKKQ 181
+ E EE V+TT+ E + EQ L ENQ L+ D L Q EL
Sbjct: 1220 KAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHT 1279
Query: 182 EELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQE 241
+EL+T + N +LEL + W+ +LKEQ+Q M K+ + L E
Sbjct: 1280 KELKTSLN-NAQLEL------NRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLE 1332
Query: 242 KEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQ 301
+E L+ Q ++Q + L ++N + EQ +++K Q ++++ K ++
Sbjct: 1333 EENHHLLSQIQLLSQQNQMLLEQN----MENKEQYHEEQK--QYIDKLNALRRHKEKLEE 1386
Query: 302 ELMDEN--FDLSKRLSENEIICNALQRQ-KERLEGENDLLKRENSRLLSYMGLDFNSLPY 358
++MD+ +D + + I AL + K + EG + LK +S P+
Sbjct: 1387 KIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKS-----------TVDSPPW 1435
Query: 359 QVPTSD 364
Q+ +SD
Sbjct: 1436 QLESSD 1441
Score = 47.8 bits (112), Expect = 2e-05
Identities = 61/283 (21%), Positives = 119/283 (42%), Gaps = 69/283 (24%)
Query: 130 EEDILVVTTQGE-VEEIEQHNKELCKENQELKDSCISLQKQ-----NSDMQAELQKKQEE 183
EE + +G+ V E+E+ N +L + +L+ + +K+ +M E+ +KQ
Sbjct: 367 EEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSM 426
Query: 184 LET------LQSINKKLELKVKEQKDYW-------ETELLQLKEQNQKMSS--------- 221
E+ L+ ++K +L +K + + +L+L+++NQ + S
Sbjct: 427 NESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDAS 486
Query: 222 ---------------ENEKMGIRVDQLQAQLSTQEKEMEKL-------------VQGDQ- 252
EN ++ ++++LQ QL +++ + L +Q D
Sbjct: 487 LVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDME 546
Query: 253 ----DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENF 308
DK Q++ L++E DHL ++ R ++ + +MK E Q + + N
Sbjct: 547 TLKADKARQIKDLEQEKDHLNRAMWSLR--ERSQVSSEARMKDVEKENKALHQTVTEANG 604
Query: 309 DLSKRLSENEIICNALQRQK------ERLEGENDLLKRENSRL 345
LS+ E + L++ K E+LE E L+ EN RL
Sbjct: 605 KLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRL 647
Score = 45.1 bits (105), Expect = 1e-04
Identities = 48/225 (21%), Positives = 105/225 (46%), Gaps = 32/225 (14%)
Query: 137 TTQGEVEEIEQHNKELCKENQELKDSCISLQ----------KQNSDMQAELQKKQEELET 186
T +VE +E ++ L EN+ L+ S +LQ + N + AE + + +ET
Sbjct: 656 TATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVET 715
Query: 187 LQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQ---AQLSTQEKE 243
++ + KL +E + +L + KE+ +K + +G + ++L+ +S +
Sbjct: 716 MRFTSTKLAQMERENQ-----QLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLR 770
Query: 244 MEKLVQGDQDKTEQLEQ-----------LKKENDHLFLS---LTEQRKDQKKLEQTVEQM 289
+++ ++ KT+ LE L+++ + L L+ L KD+K LEQ V Q+
Sbjct: 771 LQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQL 830
Query: 290 KQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGE 334
++++ K+ + L + L ++ +A++++ L+ E
Sbjct: 831 EKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKE 875
Score = 40.8 bits (94), Expect = 0.003
Identities = 36/175 (20%), Positives = 79/175 (45%), Gaps = 12/175 (6%)
Query: 131 EDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSI 190
+D ++ + ++ +E+ ++ L KE +D+ L++ D + ++ TL ++
Sbjct: 851 KDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTL 910
Query: 191 NKKLEL-KVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQ 249
+ L L K+K Q QL + K+S E EK+G+ + L + + K+++
Sbjct: 911 REDLVLEKLKSQ---------QLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILE 961
Query: 250 GDQDKTEQLEQLKKENDHLFL--SLTEQRKDQKKLEQTVEQMKQNETTAMKKQQE 302
G + + KE + L + E+ ++LE ++ +K+ T + Q E
Sbjct: 962 GRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGE 1016
Score = 37.4 bits (85), Expect = 0.028
Identities = 49/240 (20%), Positives = 108/240 (45%), Gaps = 34/240 (14%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQK---QNSDMQAELQKKQEELETLQSINKK------ 193
+E+E ++L E+ + LQK +N + A+ + + + L S+ +K
Sbjct: 268 QELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVER 327
Query: 194 LELKVKEQK------DYWETELLQLKEQN----------QKMSSENEKMGIRVDQLQAQ- 236
LEL++ K D+++ + +L+E N ++ + G +V +L+ +
Sbjct: 328 LELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKEN 387
Query: 237 LSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTA 296
L + K + + D DK +++E+L +EN L ++ + + L +EQ+ +N +
Sbjct: 388 LQLKSKLHDLELDRDTDK-KRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLS 446
Query: 297 MKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSL 356
++ + F+L++ S + L+++ + L+ L R+ S +L GL L
Sbjct: 447 DASRKSFV---FELNECASSRIL---KLEKENQSLQSTIQGL-RDASLVLEESGLKCGEL 499
Score = 36.2 bits (82), Expect = 0.062
Identities = 49/235 (20%), Positives = 101/235 (42%), Gaps = 20/235 (8%)
Query: 137 TTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAE---LQKKQEEL----ETLQS 189
T Q + +++ N L ++ L LQ ++ + E LQ++QE+L E L
Sbjct: 1110 TLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQ 1169
Query: 190 INKKLELKVKEQKDYWETELLQ---LKEQNQKMSSENEKMGIRVDQL---QAQLSTQEKE 243
++ L + Q +E + Q LK ++ + E++++G R + +A+L +EK
Sbjct: 1170 DHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKV 1229
Query: 244 M--EKLVQGDQDKTEQL-----EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTA 296
+ E+ + +T L ++L+ E D + + + + ++L +++K + A
Sbjct: 1230 LTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNA 1289
Query: 297 MKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGL 351
+ +L ++ +I L E L L+ EN LLS + L
Sbjct: 1290 QLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQL 1344
Score = 30.4 bits (67), Expect = 3.4
Identities = 31/113 (27%), Positives = 55/113 (48%), Gaps = 17/113 (15%)
Query: 219 MSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKD 278
+SSE+++ L +L+ + + ++ Q +DKTEQL + E D L L L
Sbjct: 244 LSSEDKQ------HLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLEL------ 291
Query: 279 QKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERL 331
+K++Q Q+ + +A + EL D + + R+ E+ L R KE+L
Sbjct: 292 -QKVKQENIQLAADARSARAYRDEL-DSLREKANRVERLEL---ELTRCKEKL 339
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 64.7 bits (156), Expect = 2e-10
Identities = 50/226 (22%), Positives = 118/226 (52%), Gaps = 16/226 (7%)
Query: 124 QFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEE 183
Q + EN+ V+ + E+E +Q ++ + L++ L+KQ EL+ ++E
Sbjct: 80 QAKFENQLKTKVMKLENELEMAQQSAGG--RDTRFLRNEICQLEKQLEQKDRELEDMEKE 137
Query: 184 LETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKE 243
LE + +N++L L+ +E E E +L+ +N+++ +NE++ + Q Q+ +Q+
Sbjct: 138 LEKEKKVNEQLALRNEEA----ENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQK-- 191
Query: 244 MEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQR---KDQKKLEQTVEQMKQNETTAMKKQ 300
E L+ + ++ QL K+N L L E + + +K+E ++M++N ++++
Sbjct: 192 -ETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEM 250
Query: 301 QELMDENFDLSKRLSENEIICNALQRQKE----RLEGENDLLKREN 342
+++ DE + + + + + + L+++ + +++ DLLK +N
Sbjct: 251 EKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKN 296
Score = 57.4 bits (137), Expect = 3e-08
Identities = 56/251 (22%), Positives = 114/251 (45%), Gaps = 44/251 (17%)
Query: 136 VTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLE 195
V T + + + + +++ L + L+K + D+ E Q++ EL+ + N KL+
Sbjct: 1614 VPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDL--ERQREITELKVKEFENIKLQ 1671
Query: 196 L---------KVKEQKDYWETELLQLKEQNQKMSSENEK------------MGIRVDQLQ 234
L KVK + + + L Q ++++Q + SE + M V++L+
Sbjct: 1672 LQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLK 1731
Query: 235 AQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQ------ 288
+QL+ +EK+ + L + + ++ +E +S T Q++ ++Q V++
Sbjct: 1732 SQLALKEKQQKALSRALLELRAEMTAAAEER---IISATSQKEAHLNVQQIVDRHTRELK 1788
Query: 289 ------------MKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGEND 336
+K+ T+ ++ L D DL+ L + + N + R+KE ++ END
Sbjct: 1789 TQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQEND 1848
Query: 337 LLKRENSRLLS 347
LKR+ RL S
Sbjct: 1849 ELKRQIKRLTS 1859
Score = 55.5 bits (132), Expect = 1e-07
Identities = 52/264 (19%), Positives = 119/264 (45%), Gaps = 55/264 (20%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQ--------------NSDMQAELQKKQ--- 181
+ E ++ + NK L K+N++L I QKQ +SD +++L KK
Sbjct: 156 ENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYEL 215
Query: 182 ----EELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQL 237
+E++TL N+K+E++ +E + E + ++ +KM+ E +M V Q +
Sbjct: 216 IQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEM----EKMTDEYNRMKAIVHQTDNVI 271
Query: 238 STQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQK-----KLEQTVE----- 287
+KE + Q+ T+ L+ +E+D + +++ + ++ K K ++ +E
Sbjct: 272 DQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQML 331
Query: 288 ----------QMKQNETTAMKKQQELMDENFDL----------SKRLSENEIICNALQRQ 327
Q+ +++ M QQ + + + + +K + +N I L+ +
Sbjct: 332 HNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNE 391
Query: 328 KERLEGENDLLKRENSRLLSYMGL 351
+R +G + L ++ + ++ S + +
Sbjct: 392 LQRNKGASTLSQQTHMKIQSTLDI 415
Score = 49.7 bits (117), Expect = 5e-06
Identities = 57/232 (24%), Positives = 106/232 (45%), Gaps = 37/232 (15%)
Query: 133 ILVVTTQGEVEEIEQHNKEL------CKENQEL-KDSCIS-LQKQNSDMQAELQKKQEEL 184
I + ++ E+EE+++ N +L + +Q L +DS + L QN +Q +L +++
Sbjct: 1977 IRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQF 2036
Query: 185 ETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEM 244
+ K + E D+ + E +L+++N K+SSEN +L+ QL K++
Sbjct: 2037 S--KDTYSKPSISGIESDDHCQREQ-ELQKENLKLSSEN-------IELKFQLEQANKDL 2086
Query: 245 EKLVQGDQDKTEQLEQLKKENDHLFLSLTEQR------KDQKKLEQTVEQMKQNETTAMK 298
+L +D E E LKKE + L R K +LE+T+ MK+ +
Sbjct: 2087 PRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQR 2146
Query: 299 KQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMG 350
+ ++L + L+ N +E EN+ LK E +L +++G
Sbjct: 2147 ENEQLKKASGILTSEKMAN-------------IEQENEKLKAELEKLKAHLG 2185
Score = 47.0 bits (110), Expect = 4e-05
Identities = 52/203 (25%), Positives = 96/203 (47%), Gaps = 33/203 (16%)
Query: 144 EIEQHNKELCK-ENQ--ELKDSCISLQKQNSDMQAELQ---------KKQEELETLQSIN 191
++EQ NK+L + +NQ +LK+ C L+K+ +++Q +L K ELE +
Sbjct: 2078 QLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLM 2137
Query: 192 KKLELKV-KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQG 250
KK+ KV +E + + + E+ + ENEK+ +++L+A L Q L
Sbjct: 2138 KKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQ------LSMH 2191
Query: 251 DQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDL 310
+ KT+ E++ EN+ L RK+ KK E+++ K E+++E +
Sbjct: 2192 YESKTKGTEKIIAENERL-------RKELKKETDAAEKLR-----IAKNNLEILNEK--M 2237
Query: 311 SKRLSENEIICNALQRQKERLEG 333
+ +L E + + +LEG
Sbjct: 2238 TVQLEETGKRLQFAESRGPQLEG 2260
Score = 45.1 bits (105), Expect = 1e-04
Identities = 57/253 (22%), Positives = 110/253 (43%), Gaps = 32/253 (12%)
Query: 103 EYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDS 162
+Y Y ED VV + Q + + E I ++T E+ ++E + EN+ L++
Sbjct: 450 DYESGVYGLEDAVVEIKNCKNQIKIRDRE-IEILTK--EINKLELKISDFLDENEALRER 506
Query: 163 CISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSE 222
K D+ K + + ++ N+ L +++ E E L LK++ ++M+ E
Sbjct: 507 VGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESL----EEERLDLKKKIRQMAQE 562
Query: 223 NEKMGIRVDQLQAQLSTQEKEM-EKLVQGDQDKTEQLEQL--------KKENDHLFLSLT 273
K + L+T++ + E + QGD+ +L+ L + +N+ L L
Sbjct: 563 RGKRSAT-----SGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELI 617
Query: 274 EQRKD-----------QKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICN 322
E+ +D Q KL++ VE+ KQ E + Q + + D + E +I
Sbjct: 618 EKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIP 677
Query: 323 ALQRQKERLEGEN 335
+L+R +E +N
Sbjct: 678 SLERLVNAIESKN 690
Score = 44.7 bits (104), Expect = 2e-04
Identities = 58/292 (19%), Positives = 130/292 (44%), Gaps = 49/292 (16%)
Query: 98 LPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQ 157
+P + + + VD D + R + E +++L+ ++ EV E++ +E
Sbjct: 1 MPPNINWKEIMKVDPDDLPR--------QEELADNLLISLSKVEVNELKSEKQENVIHLF 52
Query: 158 ELKDSCISLQKQNSDMQAE-LQKKQEELETLQSINKKLELKVKEQKDYWETELLQLK--- 213
+ S + ++ Q ++ E ++K EE ++ +LK K K E E+ Q
Sbjct: 53 RITQSLMKMKAQEVELALEEVEKAGEEQAKFEN-----QLKTKVMKLENELEMAQQSAGG 107
Query: 214 EQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLT 273
+ + +E ++ +++Q +L EKE+EK + ++ + E+ + EN L
Sbjct: 108 RDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKL----- 162
Query: 274 EQRKDQKKLEQTVEQM------------KQNETTAMKK------QQELMDENFDLSKRLS 315
R++ K+L++ EQ+ Q ET ++ + +L +N++L + L
Sbjct: 163 --RRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLD 220
Query: 316 ENEIICNALQRQKERLEGENDLLKR---ENSRLLSYMGLDFNSLPYQVPTSD 364
E + + A E++E +N +++ E+ + + M ++N + V +D
Sbjct: 221 EIQTLTEA----NEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTD 268
Score = 43.9 bits (102), Expect = 3e-04
Identities = 55/248 (22%), Positives = 110/248 (44%), Gaps = 50/248 (20%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQK--------QNSDMQAE-----LQKKQEELETLQS 189
E++EQ+ KE+ K ++D LQ+ Q + M+ + L++K +E E
Sbjct: 369 EQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAE 428
Query: 190 I--------NKKLELKVKEQKDY------WETELLQLK----------EQNQKMSSENEK 225
+ +K+L +K KDY E ++++K + + ++ E K
Sbjct: 429 LAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINK 488
Query: 226 MGIRV-------DQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFL---SLTEQ 275
+ +++ + L+ ++ + K M L + K + +Q + EN L SL E+
Sbjct: 489 LELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEE 548
Query: 276 RKDQKK--LEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEG 333
R D KK + E+ K++ T+ + + + EN R+SE ++ +L+ E +
Sbjct: 549 RLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSE-AQS 607
Query: 334 ENDLLKRE 341
+N+ L RE
Sbjct: 608 KNEFLSRE 615
Score = 42.4 bits (98), Expect = 9e-04
Identities = 46/237 (19%), Positives = 103/237 (43%), Gaps = 27/237 (11%)
Query: 145 IEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDY 204
I N+ L QEL++ +K+ +++ L+ + ++ L + +K+
Sbjct: 777 INSQNEYLIHLLQELENK----EKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKET 832
Query: 205 WETELLQLKEQNQKMSSENEKMGIRV---DQLQAQLSTQEKEMEKLVQGDQDKTEQLE-- 259
W+TE +KE+ +K+ + ++ I+V + L L EM+K++ + K L+
Sbjct: 833 WKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVN 892
Query: 260 ----------------QLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQEL 303
QL+KEN+ L + + +++ K+ + Q++
Sbjct: 893 EKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKV 952
Query: 304 MDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQV 360
+D + LS+ N+ + ++ L+ +N L++R ++ L ++ + SL QV
Sbjct: 953 VDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSN--LEHLECENISLKEQV 1007
Score = 41.2 bits (95), Expect = 0.002
Identities = 40/167 (23%), Positives = 78/167 (46%), Gaps = 11/167 (6%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQK 202
E + K++ + N EL+ L K N D Q Q ++EL S++K + +++
Sbjct: 1081 EHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELA--DSVSKAVSDADRQRI 1138
Query: 203 DYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKL------VQGDQDKTE 256
E ++LK + K+ ++ +V+ L AQ +++KE+E L Q D+
Sbjct: 1139 LELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKS 1198
Query: 257 QLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQEL 303
+ +L + N L LS + KLE ++++ E ++ +Q+L
Sbjct: 1199 LIAKLHQHNVSLQLS---EATALGKLESITSKLQKMEAYNLRLEQKL 1242
Score = 41.2 bits (95), Expect = 0.002
Identities = 36/175 (20%), Positives = 76/175 (43%), Gaps = 19/175 (10%)
Query: 155 ENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKE 214
+ ++ + I LQ + E++ Q+E +++ ++ELK+K ++ T LK+
Sbjct: 1282 QQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELIST----LKD 1337
Query: 215 QNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTE 274
N M I +L QE ++ + + D+++ + L + E + SL E
Sbjct: 1338 TKGAQKVINWHMKIE------ELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEE 1391
Query: 275 QRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKE 329
+ Q K + + +++Q ++ D +NEI+ NA Q+ +E
Sbjct: 1392 EIVQQNKFHEERQMAWDQREVDLERQLDIFDR--------QQNEIL-NAAQKFEE 1437
Score = 41.2 bits (95), Expect = 0.002
Identities = 45/203 (22%), Positives = 90/203 (44%), Gaps = 33/203 (16%)
Query: 135 VVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINK-- 192
+V T+ ++++ ++ K+NQ + D L K+ ++ + ++ K E+LE I K
Sbjct: 2269 IVVTRMYETKLKELETDIAKKNQSITD-LKQLVKEATEREQKVNKYNEDLEQQIKILKHV 2327
Query: 193 ----------KLELKV----KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLS 238
K EL+V Q D + EL+ E N+ S + DQL+ ++
Sbjct: 2328 PEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIP-DADQLKEKIK 2386
Query: 239 TQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKD---------------QKKLE 283
E +++ Q E++++LKKE ++ S E+ +D ++K++
Sbjct: 2387 DLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVK 2446
Query: 284 QTVEQMKQNETTAMKKQQELMDE 306
+ EQ+ T+ + +E DE
Sbjct: 2447 KLSEQLGVELTSPVAASEEFEDE 2469
Score = 40.0 bits (92), Expect = 0.004
Identities = 46/222 (20%), Positives = 93/222 (41%), Gaps = 41/222 (18%)
Query: 124 QFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEE 183
++R ++D ++V +E +E N ISL++Q + EL+ +E+
Sbjct: 975 KYRDILQKDNMLVQRTSNLEHLECEN--------------ISLKEQVESINKELEITKEK 1020
Query: 184 LETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKE 243
L T++ Q EQ K+ +E+ + + + + K+
Sbjct: 1021 LHTIE----------------------QAWEQETKLGNESSMDKAKKSITNSDIVSISKK 1058
Query: 244 MEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQEL 303
+ L + ++ ++ E +K +HL SL + + +LE ++ + A K +Q L
Sbjct: 1059 ITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQML 1118
Query: 304 MDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
DE D S ++ + +A +++ LE LK E S+L
Sbjct: 1119 RDELAD-----SVSKAVSDADRQRILELEKNEMELKVEVSKL 1155
Score = 39.3 bits (90), Expect = 0.007
Identities = 44/206 (21%), Positives = 92/206 (44%), Gaps = 28/206 (13%)
Query: 167 QKQNSDMQAELQKKQEELETLQSINKKLELKVKE------QKDYWETELLQ-LKEQNQKM 219
Q +N + EL +K+ +LE +++ K + K+KE Q + E+LQ +KE +
Sbjct: 606 QSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDP 665
Query: 220 SSENEKMGIRVDQLQAQLSTQE-KEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKD 278
+ + + + L+ ++ E K E + Q++QL N+ L L E RK+
Sbjct: 666 DVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKE 725
Query: 279 QKKLEQTVEQMK------QNETTAMKKQQ--ELMDENFDLSKRL---------SENEIIC 321
Q + + + ET+ +++ + ++ + DL + S+NE +
Sbjct: 726 AINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLI 785
Query: 322 NALQ---RQKERLEGENDLLKRENSR 344
+ LQ ++++L+ D L+ N +
Sbjct: 786 HLLQELENKEKKLKNLEDSLEDYNRK 811
Score = 39.3 bits (90), Expect = 0.007
Identities = 55/237 (23%), Positives = 107/237 (45%), Gaps = 32/237 (13%)
Query: 141 EVEEIEQHNKELCKENQEL------------KDSCIS-LQKQNSDMQAELQKKQEE--LE 185
E EEI+Q N EL ++ + L K S I LQ++ ++ +L+ K EE L+
Sbjct: 1839 EKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLK 1898
Query: 186 TLQSINKKLELKVKEQKDYWETEL----LQLKEQNQKMSSENEKMGIRVDQL----QAQL 237
++ N K EL E+ W+ ++ +LKE+ ++ + +++ D + +L
Sbjct: 1899 PMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKL 1958
Query: 238 STQEKEMEKLVQGDQ-------DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMK 290
+ Q K + DQ + ++LE+LKK N L + R Q +V +
Sbjct: 1959 TLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDL 2018
Query: 291 QNETTAMKKQQELMDENF--DLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+ ++++ +++ F D + S + I + ++++ L+ EN L EN L
Sbjct: 2019 HLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIEL 2075
Score = 38.5 bits (88), Expect = 0.012
Identities = 45/204 (22%), Positives = 95/204 (46%), Gaps = 31/204 (15%)
Query: 171 SDMQAELQKKQEELETLQSINKKLELKVKE--QKDYWETELLQLKEQNQKMSSENE---- 224
++MQA L +K+E L+ Q + +K + +E +K + +L + + Q SS N+
Sbjct: 1543 ANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQT 1602
Query: 225 ---------------KMGIRVDQLQAQLSTQEKEMEKL------VQGDQDKTEQLEQLK- 262
K IR+ +++ ++ Q+ + L V D ++ ++ +LK
Sbjct: 1603 AWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKV 1662
Query: 263 KENDHLFLSLTEQRKDQ-KKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIIC 321
KE +++ L L E +D+ KK++ VE +K + K+ Q L E +++ + +
Sbjct: 1663 KEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSEL--QAQKEANSRAPT 1720
Query: 322 NALQRQKERLEGENDLLKRENSRL 345
++ ERL+ + L +++ L
Sbjct: 1721 TTMRNLVERLKSQLALKEKQQKAL 1744
Score = 37.0 bits (84), Expect = 0.036
Identities = 39/199 (19%), Positives = 92/199 (46%), Gaps = 17/199 (8%)
Query: 144 EIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKD 203
E+E++ EL E +L++ ++Q + A+ Q + +E+E+L +++L + +
Sbjct: 1140 ELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESL-----RMQLLDYQAQS 1194
Query: 204 YWETELLQLKEQNQKMS-SENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLK 262
++ + +L + N + SE +G +++ + ++L E +L Q +L
Sbjct: 1195 DEKSLIAKLHQHNVSLQLSEATALG-KLESITSKLQKMEAYNLRLEQ----------KLD 1243
Query: 263 KENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICN 322
++ L+ + E R K L QT++ +++ + A+ Q+ + + + +I+
Sbjct: 1244 EKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQE 1303
Query: 323 ALQRQKERLEGENDLLKRE 341
Q+E EN L+ E
Sbjct: 1304 MKNSQQEHRNMENKTLEME 1322
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 64.3 bits (155), Expect = 2e-10
Identities = 45/183 (24%), Positives = 92/183 (50%), Gaps = 15/183 (8%)
Query: 145 IEQHNKEL------CKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
+E+ NK+L + Q+ S L+ QN +Q LQ ++ E LQS N+KLE KV
Sbjct: 1023 LERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKV 1082
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
KE +Q++++ Q ++ + +++ +RV L+ Q+ E+E+E+L + ++
Sbjct: 1083 KELS-------IQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREV 1135
Query: 259 EQLKKENDHLFLSLTEQRKD--QKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSE 316
E+ + N+ L + KD +K E +NE + ++ + + + ++ L+E
Sbjct: 1136 EEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTE 1195
Query: 317 NEI 319
+ +
Sbjct: 1196 SNL 1198
Score = 49.3 bits (116), Expect = 7e-06
Identities = 54/234 (23%), Positives = 103/234 (44%), Gaps = 34/234 (14%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCIS-----LQKQNSDMQAELQKKQEELETLQSINKK 193
+G+ E+ + K +E + L D + L+K D + LQ+ Q +LE + ++
Sbjct: 826 EGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARR 885
Query: 194 LELKVKEQKDYWETE-------LLQLKEQNQKM-----SSENEKMGIRVDQ--LQAQLST 239
+ Q W +E L +L+++ Q++ +S+ E+ R+D+ L +L
Sbjct: 886 EVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQG 945
Query: 240 QEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTV----EQMKQNETT 295
E+E E + D+ QL+ L+++ L L E++ + L V +Q+ Q T
Sbjct: 946 LEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTE 1005
Query: 296 AMKKQQELMD----------ENFDLSKRLSENEIICNALQRQKERLEGENDLLK 339
M+++ D +N DL RL+ +E +LE +N LL+
Sbjct: 1006 LMQERSARQDLECDKISLERQNKDLKTRLASSEGF-QKPSASLSQLESQNQLLQ 1058
Score = 46.2 bits (108), Expect = 6e-05
Identities = 56/240 (23%), Positives = 109/240 (45%), Gaps = 40/240 (16%)
Query: 128 ENEEDILVVTTQGEV-EEIEQHNKELCKENQELKDSCISLQKQNSDMQAE---------- 176
E E+ + V+ + + E+E+ N +L K Q+L+ C K +AE
Sbjct: 661 ELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAA 720
Query: 177 ----LQKKQEELETLQSINKKLELKVKEQK---DYWETELLQLKEQNQKMSSENEKMGIR 229
L++ QEE + + LE ++KE + D E +L+++ Q++ +E +
Sbjct: 721 VETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQ----- 775
Query: 230 VDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQM 289
QL+ L+ ++E L + +LE+ ++ L ++Q+ L + +E+
Sbjct: 776 --QLEEALNASQEEEGSLAAAKRALEARLEEAQR-------GLARLGQEQQTLNRALEEE 826
Query: 290 -KQNET-----TAMKKQQELMDENFD-LSKRLSE-NEIICNALQRQKERLEGENDLLKRE 341
KQ E +++Q+ L+D D L+K L + E ALQ+ + +LE + +RE
Sbjct: 827 GKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARRE 886
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/218 (22%), Positives = 101/218 (46%), Gaps = 27/218 (12%)
Query: 136 VTTQGE----VEEIEQHNKELCKENQELKDSCISLQKQNSDM--------------QAEL 177
V QGE VEE+++ E K+ Q+L+ S + L++Q + + E
Sbjct: 358 VAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEA 417
Query: 178 QKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQL 237
Q+ +EL+ + K+L + ++ + ET++++L+ + + + + + L L
Sbjct: 418 QQSNKELQNM----KRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDL---L 470
Query: 238 STQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAM 297
T+E +E++++G Q EQL ++E L +L E+ + + + V Q Q +T +
Sbjct: 471 ETREL-LEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQL 529
Query: 298 KK-QQELMDENFDLSKRLSENEIICNALQRQKERLEGE 334
++ Q+ ++ L + + LQR+ E E
Sbjct: 530 RRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEE 567
Score = 43.9 bits (102), Expect = 3e-04
Identities = 55/238 (23%), Positives = 97/238 (40%), Gaps = 37/238 (15%)
Query: 140 GEVEEIEQHNKELCKENQELKDSCISLQKQ--------------------NSDMQAELQK 179
G+ ++E KEL + +ELK+ Q Q +D EL++
Sbjct: 622 GDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEE 681
Query: 180 KQEELE-TLQSINKKLELKVKEQKDYWETELLQLKEQN-------QKMSSENEKMGIRVD 231
+ +L+ TLQ + + E + + K E E L ++ ++ EN++ R+
Sbjct: 682 QNLQLQKTLQQLRQDCE-EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRIL 740
Query: 232 QLQAQLSTQEKEMEKLVQG----DQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVE 287
L+ QL KE LV G + ++L++L+ E L +L ++++ L
Sbjct: 741 GLEQQL----KETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKR 796
Query: 288 QMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
++ A + L E L++ L E L+R K LE + LL R RL
Sbjct: 797 ALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRL 854
Score = 37.4 bits (85), Expect = 0.028
Identities = 38/193 (19%), Positives = 87/193 (45%), Gaps = 14/193 (7%)
Query: 142 VEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQ 201
V+ E + L K+ E ++ + + ++ +L+ ++ EL L+ +KE+
Sbjct: 455 VQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGA-------LKEE 507
Query: 202 KDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQL 261
+ E+ +++Q Q+ + + + Q A L + ++M LV+G Q +LE+
Sbjct: 508 VASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQ---RELEET 564
Query: 262 KKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIIC 321
+E H + ++D + +Q + Q++ + ++ +E + E ++ +R E
Sbjct: 565 SEETGHWQSMFQKNKEDLRATKQELLQLRMEK----EEMEEELGEKIEVLQRELEQARAS 620
Query: 322 NALQRQKERLEGE 334
RQ E L+ E
Sbjct: 621 AGDTRQVEVLKKE 633
Score = 34.7 bits (78), Expect = 0.18
Identities = 19/86 (22%), Positives = 45/86 (52%)
Query: 128 ENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETL 187
E E+ +L T + ++++ + ++ E Q + D L + ++ ++ + +EE+E L
Sbjct: 1065 EREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERL 1124
Query: 188 QSINKKLELKVKEQKDYWETELLQLK 213
+ KK + +V+EQ + E ++K
Sbjct: 1125 DGLRKKAQREVEEQHEVNEQLQARIK 1150
Score = 34.3 bits (77), Expect = 0.24
Identities = 19/63 (30%), Positives = 33/63 (52%)
Query: 279 QKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLL 338
Q +L + VE++++ +KK+Q+L L ++L E C+ LQ ER +GE
Sbjct: 361 QGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQS 420
Query: 339 KRE 341
+E
Sbjct: 421 NKE 423
Score = 33.9 bits (76), Expect = 0.31
Identities = 41/198 (20%), Positives = 86/198 (43%), Gaps = 24/198 (12%)
Query: 165 SLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENE 224
S+ + + L++ E ET S+ +K+ L +++ + L+ + + K +
Sbjct: 310 SVDHMKATIYGILREGSSESET--SVRRKVSLVLEKMQP-----LVMVSSGSTKAVAGQG 362
Query: 225 KMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQ 284
++ +V++LQ +L + K+ +KL QLE+ +E L L ++ + ++ +
Sbjct: 363 ELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNK 422
Query: 285 TVEQMKQ-----------NETTAMKKQQELMDENFD------LSKRLSENEIICNALQRQ 327
++ MK+ ET M+ Q +L L K L E + +
Sbjct: 423 ELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEG 482
Query: 328 KERLEGENDLLKRENSRL 345
K+R+E + L +RE + L
Sbjct: 483 KQRVEEQLRLRERELTAL 500
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 63.9 bits (154), Expect = 3e-10
Identities = 54/214 (25%), Positives = 93/214 (43%), Gaps = 24/214 (11%)
Query: 142 VEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQ--------------EELETL 187
VEE E+ N EL ++L+D C L+K+ D++ L K + EE+E L
Sbjct: 938 VEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFL 997
Query: 188 QSINKKLELKVKEQKDYWETELLQLKEQNQKMSS---ENEKMGIRVDQLQAQLSTQ---- 240
KL K ++ + L L + +K+SS N K+ +VD+L+ L +
Sbjct: 998 NEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKAR 1057
Query: 241 ---EKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAM 297
E+E+ KL + E +E L+ HL L ++ + ++ VE K
Sbjct: 1058 MNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQ 1117
Query: 298 KKQQELMDENFDLSKRLSENEIICNALQRQKERL 331
K +EL + DL ++L ++R++ L
Sbjct: 1118 KTVKELQTQIKDLKEKLEAERTTRAKMERERADL 1151
Score = 54.7 bits (130), Expect = 2e-07
Identities = 50/204 (24%), Positives = 97/204 (47%), Gaps = 33/204 (16%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
Q ++++++ + + N +LK+ +++NS +Q+EL E+L +LQ +
Sbjct: 1659 QIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSEL----EDLRSLQE-------QT 1707
Query: 199 KEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
+ + E ELL+ E+ ++N + + +L+A ++ +KE E++VQ Q+ E+
Sbjct: 1708 ERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKA 1767
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENE 318
++ E +L L +++ LE+T E M+Q T DL KRL+E E
Sbjct: 1768 KKAAIEAANLSEELKKKQDTIAHLERTRENMEQTIT--------------DLQKRLAEAE 1813
Query: 319 IIC--------NALQRQKERLEGE 334
+ L+ + LEGE
Sbjct: 1814 QMALMGSRKQIQKLESRVRELEGE 1837
Score = 52.4 bits (124), Expect = 8e-07
Identities = 50/215 (23%), Positives = 99/215 (46%), Gaps = 18/215 (8%)
Query: 128 ENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETL 187
ENE+ LV Q V+E++ K+L ++ + + + ++++ +D+ +L E LE +
Sbjct: 1107 ENEKG-LVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEV 1165
Query: 188 QS-------INKKLELK-------VKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQL 233
I KK E K ++E ++ET LK+++ +E E + Q+
Sbjct: 1166 GGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQV 1225
Query: 234 QAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNE 293
+ +L + +++ V + EQ+ + K + L +L E+R + + N+
Sbjct: 1226 KQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKL-CTLYEERLHEATAKLDKVTQLAND 1284
Query: 294 TTAMKKQQELMDENFDLSKRLSENEIICNALQRQK 328
A K + L E+ + +RL E E + N L R+K
Sbjct: 1285 LAAQKTK--LWSESGEFLRRLEEKEALINQLSREK 1317
Score = 51.6 bits (122), Expect = 1e-06
Identities = 49/214 (22%), Positives = 102/214 (47%), Gaps = 14/214 (6%)
Query: 123 FQFRPENEEDILVVTTQGEVEEIEQHNKELCK---ENQELKDSCISLQKQNSDMQAELQK 179
F+ +P + + G EE Q K L K + +ELK +SL ++ +D+ +LQ
Sbjct: 846 FKIKPLVKSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQA 905
Query: 180 KQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLST 239
+QE TL ++ ++ E +K K E + +L E+ ++ N ++ R +L+ +
Sbjct: 906 EQE---TLANVEEQCEWLIKS-KIQLEARVKELSERVEEEEEINSELTARGRKLEDECFE 961
Query: 240 QEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKK 299
+KE++ L + + E+ K+ +H +LTE+ + L + + ++ + +
Sbjct: 962 LKKEIDDL----ETMLVKSEKEKRTTEHKVKNLTEE---VEFLNEDISKLNRAAKVVQEA 1014
Query: 300 QQELMDENFDLSKRLSENEIICNALQRQKERLEG 333
Q+ +D+ ++LS L++Q + LEG
Sbjct: 1015 HQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEG 1048
Score = 49.3 bits (116), Expect = 7e-06
Identities = 52/226 (23%), Positives = 107/226 (47%), Gaps = 31/226 (13%)
Query: 128 ENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQ----KKQEE 183
E E+ + VT + +E++ ++ EL ++ L+++ S+ E++ K+Q
Sbjct: 1546 EEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCT 1605
Query: 184 LETLQS-----INKKLE---LKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQA 235
+++LQS ++E LK K ++D E EL QL N+++S + +G QLQ
Sbjct: 1606 IDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMEL-QLSCANRQVSEATKSLG----QLQI 1660
Query: 236 QLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETT 295
Q+ + +++ Q + D EQ+ ++ N L Q +LE +Q E
Sbjct: 1661 QIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLL----------QSELEDLRSLQEQTERG 1710
Query: 296 AMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
++EL++ ++ ++N +L QK++LE + +++E
Sbjct: 1711 RRLSEEELLEATERINLFYTQN----TSLLSQKKKLEADVARMQKE 1752
Score = 39.3 bits (90), Expect = 0.007
Identities = 39/173 (22%), Positives = 79/173 (45%), Gaps = 12/173 (6%)
Query: 169 QNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGI 228
Q M+ + QK EE + L I + + + W ++K + E G+
Sbjct: 805 QGKLMRIKFQKILEERDALILIQWNIRAFMAVKNWPWMRLFFKIKPLVKSSEVGEEVAGL 864
Query: 229 RVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQ 288
+ + Q Q + ++ E ++ ++ K +Q+ +++ND L L L +++ +E+ E
Sbjct: 865 KEECAQLQKALEKSEFQR----EELKAKQVSLTQEKND-LILQLQAEQETLANVEEQCEW 919
Query: 289 MKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
+ +K + +L +LS+R+ E E I + L + +LE E LK+E
Sbjct: 920 L-------IKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKE 965
Score = 38.9 bits (89), Expect = 0.010
Identities = 40/187 (21%), Positives = 90/187 (48%), Gaps = 17/187 (9%)
Query: 126 RPENEEDILVVTTQGEVEEIEQHNKELCKENQELK---DSCISLQKQNSDMQ---AELQK 179
R + E + +V Q E+ ++ E ++ELK D+ L++ +M+ +LQK
Sbjct: 1748 RMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQK 1807
Query: 180 KQEELETLQSIN-----KKLELKVKEQKDYWETELLQLKEQNQ---KMSSENEKMGIRVD 231
+ E E + + +KLE +V+E + E E+ + E + ++ +++ + +
Sbjct: 1808 RLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAE 1867
Query: 232 QLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQ 291
+ + LS + +M+KL Q+ +Q+E + + + L++ +K Q +L + E+ +
Sbjct: 1868 EDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQY---LSKYKKQQHELNEVKERAEV 1924
Query: 292 NETTAMK 298
E+ K
Sbjct: 1925 AESQVNK 1931
Score = 33.1 bits (74), Expect = 0.52
Identities = 29/140 (20%), Positives = 69/140 (49%), Gaps = 15/140 (10%)
Query: 124 QFRPENEEDILVVTTQGEVEEIEQHNKEL-------CKENQELKDSCISLQKQNSDMQAE 176
Q R E + ++ ++ +++++E +EL + + E + L++ ++ +
Sbjct: 1806 QKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQ 1865
Query: 177 LQKKQEELETLQSINKKLELKV---KEQKDYWETE----LLQLKEQNQKMSSENEKMGIR 229
++ ++ L +Q+ KL+LKV K+Q + ET+ L + K+Q +++ E+ +
Sbjct: 1866 AEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVA 1925
Query: 230 VDQLQAQLSTQEKEMEKLVQ 249
Q+ +L + +E K VQ
Sbjct: 1926 ESQVN-KLKIKAREFGKKVQ 1944
Score = 32.0 bits (71), Expect = 1.2
Identities = 53/252 (21%), Positives = 98/252 (38%), Gaps = 48/252 (19%)
Query: 144 EIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKD 203
+IE +L KE + +LQK D ++ +EE E +++ L KV +
Sbjct: 1323 QIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLS-KVNAEMV 1381
Query: 204 YW----ETELLQ--------LKEQNQKMSSENEKMGI----------RVDQLQAQLSTQE 241
W E ++Q KE ++ E MG+ QLQ +L
Sbjct: 1382 QWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDAL 1441
Query: 242 KEMEK-------LVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQK-------KLEQTVE 287
++ K L Q + L K++++ L +K+ + KL+ T E
Sbjct: 1442 SDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYE 1501
Query: 288 QMKQNETTAMKKQQELMDENFDL-------SKRLSENEIICNALQRQKER----LEGEND 336
+ + T ++ + L +E +L +K L+E E + ++ +K LE
Sbjct: 1502 ESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEG 1561
Query: 337 LLKRENSRLLSY 348
L+R S++L +
Sbjct: 1562 ALERNESKILHF 1573
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 63.5 bits (153), Expect = 4e-10
Identities = 54/225 (24%), Positives = 104/225 (46%), Gaps = 15/225 (6%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQ- 188
+E L + Q +++E++ +EL +E + + S +KQ SD+ EL++ E LE
Sbjct: 1102 DEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG 1161
Query: 189 ------SINKKLELKVKEQKDYWETELLQLKEQ----NQKMSSENEKMGIRVDQLQAQLS 238
+NKK E + ++ + E LQ + +K + ++G ++D LQ
Sbjct: 1162 ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQ 1221
Query: 239 TQEKEMEKLVQGDQDKTEQLEQLKKENDHL--FLSLTEQRKDQKKLEQTVEQMKQNETTA 296
EKE ++ D +E + K +L E + + K ++ +Q N+ TA
Sbjct: 1222 KLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA 1281
Query: 297 MKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
+ + L E+ + S++L E E + + L R K+ + + LKR+
Sbjct: 1282 QRGR--LQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1324
Score = 57.4 bits (137), Expect = 3e-08
Identities = 45/206 (21%), Positives = 102/206 (49%), Gaps = 17/206 (8%)
Query: 138 TQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELK 197
TQG +++ + H + + ++LK+ ++++ + +QAE+++ + LE + K
Sbjct: 1652 TQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK----- 1706
Query: 198 VKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQ 257
+ EQ ELL E+ Q + ++N + +L+ +S + EME ++Q ++ E+
Sbjct: 1707 IAEQ------ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEK 1760
Query: 258 LEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSEN 317
++ + + E+ K ++ +E+MK+N +K Q +DE L+ + +
Sbjct: 1761 AKKAITD----AAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1816
Query: 318 EIICNALQRQKERLEGENDLLKRENS 343
+I L+ + LEGE + ++ N+
Sbjct: 1817 QI--QKLEARVRELEGEVESEQKRNA 1840
Score = 50.8 bits (120), Expect = 2e-06
Identities = 51/237 (21%), Positives = 114/237 (48%), Gaps = 35/237 (14%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
EED + T+ +++ +EQ +L ++ K + L++ ++ +L+ QE + ++
Sbjct: 1019 EEDKVNTLTKAKIK-LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIE- 1076
Query: 190 INKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQ 249
N+K +L K +K +E LQ K +++ + +GI++ + +L + +E+E+ ++
Sbjct: 1077 -NEKQQLDEKLKKKEFEISNLQSKIEDE------QALGIQLQKKIKELQARIEELEEEIE 1129
Query: 250 GDQ-----------DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMK-------- 290
++ D + +LE++ + + + + Q + KK E ++M+
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189
Query: 291 QNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLS 347
Q+E TA +++ D +L +++ LQR K++LE E +K E L S
Sbjct: 1190 QHEATAATLRKKHADSVAELGEQIDN-------LQRVKQKLEKEKSEMKMEIDDLAS 1239
Score = 50.4 bits (119), Expect = 3e-06
Identities = 53/226 (23%), Positives = 102/226 (45%), Gaps = 22/226 (9%)
Query: 132 DILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQA-------ELQKKQEEL 184
++ + + E E K L +E L ++ L K+ +Q +LQ +++++
Sbjct: 964 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV 1023
Query: 185 ETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEM 244
TL K ++K+++Q D E L Q E+ +M E K + D AQ S + E
Sbjct: 1024 NTL----TKAKIKLEQQVDDLEGSLEQ--EKKLRMDLERAKRKLEGDLKLAQESIMDIEN 1077
Query: 245 EKLVQGDQDKTEQLE---QLKKENDHLFLSLTEQRKDQ------KKLEQTVEQMKQNETT 295
EK ++ K ++ E K D L + Q+K + ++LE+ +E + +
Sbjct: 1078 EKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAK 1137
Query: 296 AMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
A K++ +L E ++S+RL E +A ++ E E ++R+
Sbjct: 1138 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD 1183
Score = 48.5 bits (114), Expect = 1e-05
Identities = 53/212 (25%), Positives = 105/212 (49%), Gaps = 34/212 (16%)
Query: 139 QGEVEEI--EQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLEL 196
QGE+E+I E N E K + + D+ + M EL+K+Q+ L+ + K +E
Sbjct: 1744 QGEMEDILQEARNAEE-KAKKAITDAAM--------MAEELKKEQDTSAHLERMKKNMEQ 1794
Query: 197 KVKE-QKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKT 255
VK+ Q E E L LK +++ +K+ RV +L+ ++ +++K + V+G +
Sbjct: 1795 TVKDLQLRLDEAEQLALKGGKKQI----QKLEARVRELEGEVESEQKRNAEAVKGLRKHE 1850
Query: 256 EQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDE--NFDLSKR 313
++++L + + E RK+ +L+ V+++ Q + + K+Q E +E N +L+K
Sbjct: 1851 RRVKELTYQTE-------EDRKNILRLQDLVDKL-QAKVKSYKRQAEEAEEQSNTNLAK- 1901
Query: 314 LSENEIICNALQRQKERLEGENDLLKRENSRL 345
LQ + E E D+ + + ++L
Sbjct: 1902 -------FRKLQHELEEAEERADIAESQVNKL 1926
Score = 48.1 bits (113), Expect = 2e-05
Identities = 60/245 (24%), Positives = 114/245 (46%), Gaps = 36/245 (14%)
Query: 124 QFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKD-------SCISLQKQNSDMQAE 176
Q+R + E D + T EE+E+ K+L + Q ++ C SL+K +Q E
Sbjct: 1376 QWRTKYETDAIQRT-----EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNE 1430
Query: 177 LQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQ 236
++ ++E + L+ K+Q+++ + L E QK E+ ++ Q +
Sbjct: 1431 VEDLMLDVERTNAACAALD---KKQRNFDKI----LAEWKQKC----EETHAELEASQKE 1479
Query: 237 LSTQEKEMEKLVQGDQDKTEQLEQLKKENDHL---FLSLTEQ-------RKDQKKLEQTV 286
+ E+ K+ ++ +QLE LK+EN +L LTEQ + +K+++ V
Sbjct: 1480 ARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQV 1539
Query: 287 EQMKQNETTAMKKQQELM--DENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSR 344
EQ K A+++ + + +E L +L N++ ++ E+ E E D LKR + R
Sbjct: 1540 EQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDE-EIDQLKRNHIR 1598
Query: 345 LLSYM 349
++ M
Sbjct: 1599 IVESM 1603
Score = 44.7 bits (104), Expect = 2e-04
Identities = 37/155 (23%), Positives = 70/155 (45%), Gaps = 2/155 (1%)
Query: 193 KLELKVKEQKDYWETE--LLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQG 250
KL K+K ETE + +KE+ QK+ E K + +L+ ++ T KE L
Sbjct: 837 KLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQ 896
Query: 251 DQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDL 310
Q + E L ++ D L + + K++ + E ++ K+++L DE +L
Sbjct: 897 VQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 956
Query: 311 SKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
K + + E+ ++++K E + L E + L
Sbjct: 957 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 991
Score = 43.9 bits (102), Expect = 3e-04
Identities = 52/234 (22%), Positives = 103/234 (44%), Gaps = 27/234 (11%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE 200
++EE+++ +E K L + S + ++ + +++QE LQ K +V +
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQ 1376
Query: 201 QKDYWETELLQ----LKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTE 256
+ +ET+ +Q L+E +K++ + V+ + A+ ++ EK ++L Q++ E
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRL----QNEVE 1432
Query: 257 QLE-QLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLS 315
L +++ N +QR K L + ++ ++ Q+E +L K
Sbjct: 1433 DLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFK--- 1489
Query: 316 ENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQVPTSDEGGAR 369
I NA + ++LE LKREN L + + L Q+ EGG R
Sbjct: 1490 ----IKNAYEESLDQLE----TLKRENKNLQQ----EISDLTEQIA---EGGKR 1528
Score = 35.8 bits (81), Expect = 0.081
Identities = 35/221 (15%), Positives = 100/221 (45%), Gaps = 26/221 (11%)
Query: 141 EVEEIEQHNKELCKENQELKDSCI--------------SLQKQNSDMQAELQKKQEELET 186
++E +++ NK L +E +L + ++++ ++QA L++ + LE
Sbjct: 1500 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEH 1559
Query: 187 LQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEK 246
+ +++L++ + K + ++ + E+ ++ + ++ V+ +Q+ L + +
Sbjct: 1560 EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRI---VESMQSTLDAEIRSRND 1616
Query: 247 LVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDE 306
++ + L +++ + +H E ++ + + ++ + + A++ Q+
Sbjct: 1617 AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQE----- 1671
Query: 307 NFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLS 347
DL ++L+ E N LQ + E L L + E SR ++
Sbjct: 1672 --DLKEQLAMVERRANLLQAEIEELRA--TLEQTERSRKIA 1708
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 63.5 bits (153), Expect = 4e-10
Identities = 54/225 (24%), Positives = 104/225 (46%), Gaps = 15/225 (6%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQ- 188
+E L + Q +++E++ +EL +E + + S +KQ SD+ EL++ E LE
Sbjct: 1102 DEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG 1161
Query: 189 ------SINKKLELKVKEQKDYWETELLQLKEQ----NQKMSSENEKMGIRVDQLQAQLS 238
+NKK E + ++ + E LQ + +K + ++G ++D LQ
Sbjct: 1162 ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQ 1221
Query: 239 TQEKEMEKLVQGDQDKTEQLEQLKKENDHL--FLSLTEQRKDQKKLEQTVEQMKQNETTA 296
EKE ++ D +E + K +L E + + K ++ +Q N+ TA
Sbjct: 1222 KLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTA 1281
Query: 297 MKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
+ + L E+ + S++L E E + + L R K+ + + LKR+
Sbjct: 1282 QRGR--LQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1324
Score = 57.4 bits (137), Expect = 3e-08
Identities = 45/206 (21%), Positives = 102/206 (49%), Gaps = 17/206 (8%)
Query: 138 TQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELK 197
TQG +++ + H + + ++LK+ ++++ + +QAE+++ + LE + K
Sbjct: 1652 TQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK----- 1706
Query: 198 VKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQ 257
+ EQ ELL E+ Q + ++N + +L+ +S + EME ++Q ++ E+
Sbjct: 1707 IAEQ------ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEK 1760
Query: 258 LEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSEN 317
++ + + E+ K ++ +E+MK+N +K Q +DE L+ + +
Sbjct: 1761 AKKAITD----AAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1816
Query: 318 EIICNALQRQKERLEGENDLLKRENS 343
+I L+ + LEGE + ++ N+
Sbjct: 1817 QI--QKLEARVRELEGEVESEQKRNA 1840
Score = 50.8 bits (120), Expect = 2e-06
Identities = 51/237 (21%), Positives = 114/237 (48%), Gaps = 35/237 (14%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
EED + T+ +++ +EQ +L ++ K + L++ ++ +L+ QE + ++
Sbjct: 1019 EEDKVNTLTKAKIK-LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIE- 1076
Query: 190 INKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQ 249
N+K +L K +K +E LQ K +++ + +GI++ + +L + +E+E+ ++
Sbjct: 1077 -NEKQQLDEKLKKKEFEISNLQSKIEDE------QALGIQLQKKIKELQARIEELEEEIE 1129
Query: 250 GDQ-----------DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMK-------- 290
++ D + +LE++ + + + + Q + KK E ++M+
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189
Query: 291 QNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLS 347
Q+E TA +++ D +L +++ LQR K++LE E +K E L S
Sbjct: 1190 QHEATAATLRKKHADSVAELGEQIDN-------LQRVKQKLEKEKSEMKMEIDDLAS 1239
Score = 50.4 bits (119), Expect = 3e-06
Identities = 53/226 (23%), Positives = 102/226 (45%), Gaps = 22/226 (9%)
Query: 132 DILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQA-------ELQKKQEEL 184
++ + + E E K L +E L ++ L K+ +Q +LQ +++++
Sbjct: 964 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV 1023
Query: 185 ETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEM 244
TL K ++K+++Q D E L Q E+ +M E K + D AQ S + E
Sbjct: 1024 NTL----TKAKIKLEQQVDDLEGSLEQ--EKKLRMDLERAKRKLEGDLKLAQESIMDIEN 1077
Query: 245 EKLVQGDQDKTEQLE---QLKKENDHLFLSLTEQRKDQ------KKLEQTVEQMKQNETT 295
EK ++ K ++ E K D L + Q+K + ++LE+ +E + +
Sbjct: 1078 EKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAK 1137
Query: 296 AMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
A K++ +L E ++S+RL E +A ++ E E ++R+
Sbjct: 1138 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD 1183
Score = 48.5 bits (114), Expect = 1e-05
Identities = 53/212 (25%), Positives = 105/212 (49%), Gaps = 34/212 (16%)
Query: 139 QGEVEEI--EQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLEL 196
QGE+E+I E N E K + + D+ + M EL+K+Q+ L+ + K +E
Sbjct: 1744 QGEMEDILQEARNAEE-KAKKAITDAAM--------MAEELKKEQDTSAHLERMKKNMEQ 1794
Query: 197 KVKE-QKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKT 255
VK+ Q E E L LK +++ +K+ RV +L+ ++ +++K + V+G +
Sbjct: 1795 TVKDLQLRLDEAEQLALKGGKKQI----QKLEARVRELEGEVESEQKRNAEAVKGLRKHE 1850
Query: 256 EQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDE--NFDLSKR 313
++++L + + E RK+ +L+ V+++ Q + + K+Q E +E N +L+K
Sbjct: 1851 RRVKELTYQTE-------EDRKNILRLQDLVDKL-QAKVKSYKRQAEEAEEQSNTNLAK- 1901
Query: 314 LSENEIICNALQRQKERLEGENDLLKRENSRL 345
LQ + E E D+ + + ++L
Sbjct: 1902 -------FRKLQHELEEAEERADIAESQVNKL 1926
Score = 48.1 bits (113), Expect = 2e-05
Identities = 60/245 (24%), Positives = 114/245 (46%), Gaps = 36/245 (14%)
Query: 124 QFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKD-------SCISLQKQNSDMQAE 176
Q+R + E D + T EE+E+ K+L + Q ++ C SL+K +Q E
Sbjct: 1376 QWRTKYETDAIQRT-----EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNE 1430
Query: 177 LQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQ 236
++ ++E + L+ K+Q+++ + L E QK E+ ++ Q +
Sbjct: 1431 VEDLMLDVERTNAACAALD---KKQRNFDKI----LAEWKQKC----EETHAELEASQKE 1479
Query: 237 LSTQEKEMEKLVQGDQDKTEQLEQLKKENDHL---FLSLTEQ-------RKDQKKLEQTV 286
+ E+ K+ ++ +QLE LK+EN +L LTEQ + +K+++ V
Sbjct: 1480 ARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQV 1539
Query: 287 EQMKQNETTAMKKQQELM--DENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSR 344
EQ K A+++ + + +E L +L N++ ++ E+ E E D LKR + R
Sbjct: 1540 EQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDE-EIDQLKRNHIR 1598
Query: 345 LLSYM 349
++ M
Sbjct: 1599 IVESM 1603
Score = 44.7 bits (104), Expect = 2e-04
Identities = 37/155 (23%), Positives = 70/155 (45%), Gaps = 2/155 (1%)
Query: 193 KLELKVKEQKDYWETE--LLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQG 250
KL K+K ETE + +KE+ QK+ E K + +L+ ++ T KE L
Sbjct: 837 KLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQ 896
Query: 251 DQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDL 310
Q + E L ++ D L + + K++ + E ++ K+++L DE +L
Sbjct: 897 VQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 956
Query: 311 SKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
K + + E+ ++++K E + L E + L
Sbjct: 957 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 991
Score = 43.9 bits (102), Expect = 3e-04
Identities = 52/234 (22%), Positives = 103/234 (44%), Gaps = 27/234 (11%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE 200
++EE+++ +E K L + S + ++ + +++QE LQ K +V +
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQ 1376
Query: 201 QKDYWETELLQ----LKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTE 256
+ +ET+ +Q L+E +K++ + V+ + A+ ++ EK ++L Q++ E
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRL----QNEVE 1432
Query: 257 QLE-QLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLS 315
L +++ N +QR K L + ++ ++ Q+E +L K
Sbjct: 1433 DLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFK--- 1489
Query: 316 ENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQVPTSDEGGAR 369
I NA + ++LE LKREN L + + L Q+ EGG R
Sbjct: 1490 ----IKNAYEESLDQLE----TLKRENKNLQQ----EISDLTEQIA---EGGKR 1528
Score = 35.8 bits (81), Expect = 0.081
Identities = 35/221 (15%), Positives = 100/221 (45%), Gaps = 26/221 (11%)
Query: 141 EVEEIEQHNKELCKENQELKDSCI--------------SLQKQNSDMQAELQKKQEELET 186
++E +++ NK L +E +L + ++++ ++QA L++ + LE
Sbjct: 1500 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEH 1559
Query: 187 LQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEK 246
+ +++L++ + K + ++ + E+ ++ + ++ V+ +Q+ L + +
Sbjct: 1560 EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRI---VESMQSTLDAEIRSRND 1616
Query: 247 LVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDE 306
++ + L +++ + +H E ++ + + ++ + + A++ Q+
Sbjct: 1617 AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQE----- 1671
Query: 307 NFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLS 347
DL ++L+ E N LQ + E L L + E SR ++
Sbjct: 1672 --DLKEQLAMVERRANLLQAEIEELRA--TLEQTERSRKIA 1708
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 63.2 bits (152), Expect = 5e-10
Identities = 51/224 (22%), Positives = 100/224 (44%), Gaps = 11/224 (4%)
Query: 129 NEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQ 188
++E + + Q +++E++ +EL +E + ++KQ SD+ EL++ E LE
Sbjct: 1099 DDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEAS 1158
Query: 189 -------SINKKLELKVKEQKDYWETELLQLKEQ----NQKMSSENEKMGIRVDQLQAQL 237
+NKK E + ++ + E LQ + +K + ++G ++D LQ
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVK 1218
Query: 238 STQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAM 297
EKE +L D +E L K ++ + +++ EQ Q
Sbjct: 1219 QKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLN 1278
Query: 298 KKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
++ L +N +LS R+ E E + + L + K+ L + + LKR+
Sbjct: 1279 MQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQ 1322
Score = 60.1 bits (144), Expect = 4e-09
Identities = 52/235 (22%), Positives = 114/235 (48%), Gaps = 37/235 (15%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKL-ELKVK 199
+++ +++ ++L KE ELK + + S+++A + K T +++ + E+K K
Sbjct: 1210 QIDNLQRVKQKLEKEKSELK---MEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAK 1266
Query: 200 EQKDYWETELLQ-LKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQL 258
+++ +T+L+ L Q ++ ++N ++ RV++ ++ +S K + L Q ++ Q+
Sbjct: 1267 DEQ---QTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQM 1323
Query: 259 EQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQ----------------------NETTA 296
E+ K + + +L R D L + E+ ++ ET A
Sbjct: 1324 EEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDA 1383
Query: 297 MKKQQELMDENFDLSKRLSENE-------IICNALQRQKERLEGENDLLKRENSR 344
+++ +EL + L++RL E E C +L++ K+RL+GE + L R+ R
Sbjct: 1384 IQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLER 1438
Score = 58.2 bits (139), Expect = 2e-08
Identities = 43/210 (20%), Positives = 101/210 (48%), Gaps = 17/210 (8%)
Query: 137 TTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLEL 196
T QG++++ + H + + N++LK+ ++++N + EL++ + LE
Sbjct: 1649 TVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALE----------- 1697
Query: 197 KVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTE 256
+ + + E ELL ++ Q + S+N + +L+A ++ + E+E +Q ++ E
Sbjct: 1698 QTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEE 1757
Query: 257 QLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSE 316
+ ++ + + E+ K ++ +E+MK+N +K Q +DE L+ + +
Sbjct: 1758 KAKKAITD----AAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK 1813
Query: 317 NEIICNALQRQKERLEGENDLLKRENSRLL 346
+I L+ + LE E D+ ++ + L
Sbjct: 1814 KQI--QKLENRVRELENELDVEQKRGAEAL 1841
Score = 56.6 bits (135), Expect = 4e-08
Identities = 48/209 (22%), Positives = 102/209 (48%), Gaps = 21/209 (10%)
Query: 143 EEIEQHNKELCKEN---QELKDSCISLQKQNSDMQAELQKKQEEL----ETLQSINKK-- 193
E+ E+ +EL + +EL++ +SL ++ +D+Q ++Q + E L E + + K
Sbjct: 858 EDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKI 917
Query: 194 -LELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQ 252
LE KVKE + E E +E N ++ ++ + + L+ + E + K+ +
Sbjct: 918 LLEAKVKELTERLEEE----EEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKH 973
Query: 253 DKTEQLEQLKKENDHLFLSLTEQRKDQKKL----EQTVEQMKQNETTA---MKKQQELMD 305
+++ L +E L ++++ K++K L +QT++ ++ E +K +L
Sbjct: 974 ATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQ 1033
Query: 306 ENFDLSKRLSENEIICNALQRQKERLEGE 334
+ DL L + + + L+R K +LEG+
Sbjct: 1034 QTDDLEGSLEQEKKLRADLERAKRKLEGD 1062
Score = 53.5 bits (127), Expect = 4e-07
Identities = 45/207 (21%), Positives = 99/207 (47%), Gaps = 18/207 (8%)
Query: 142 VEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQ 201
+EE E+ N EL + + L+D C SL++ D++ L K ++E ++ KVK
Sbjct: 930 LEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATEN-------KVKNL 982
Query: 202 KDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGD---QDKTEQL 258
+ E+ L+E K++ E + + Q L +E ++ L++ + + +T+ L
Sbjct: 983 SE----EMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDL 1038
Query: 259 EQLKKENDHLFLSLTE-QRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSK---RL 314
E ++ L L +RK + L+ + E + E + +++L + F+LS+ ++
Sbjct: 1039 EGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKI 1098
Query: 315 SENEIICNALQRQKERLEGENDLLKRE 341
+ ++ Q++ + L+ + L+ E
Sbjct: 1099 DDEQVHSLQFQKKIKELQARIEELEEE 1125
Score = 52.8 bits (125), Expect = 6e-07
Identities = 53/191 (27%), Positives = 93/191 (48%), Gaps = 21/191 (10%)
Query: 144 EIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKD 203
E+ Q EL ++ E KD I K+NS AE + + E ++S N L LK K + D
Sbjct: 1568 ELSQVKSELDRKVIE-KDEEIEQLKRNSQRAAEALQSVLDAE-IRSRNDALRLKKKMEGD 1625
Query: 204 YWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKK 263
E E+ QL N++M+ E +K + +Q QL + ++ ++ ++D EQL +++
Sbjct: 1626 LNEMEI-QLGHSNRQMA-ETQK---HLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVER 1680
Query: 264 ENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNA 323
N L ++LE+ ++Q E T +QEL+D + + S+N + N
Sbjct: 1681 RNGLLL----------EELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINT 1730
Query: 324 LQRQKERLEGE 334
K++LE +
Sbjct: 1731 ----KKKLEAD 1737
Score = 52.4 bits (124), Expect = 8e-07
Identities = 57/239 (23%), Positives = 111/239 (46%), Gaps = 34/239 (14%)
Query: 124 QFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDS-------CISLQKQNSDMQAE 176
Q+R + E D + T EE+E+ K+L + QE +++ C SL+K +Q E
Sbjct: 1374 QWRTKYETDAIQRT-----EELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGE 1428
Query: 177 LQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQ 236
++ +LE + L+ K+Q+++ + L E QK+ ++ + Q +
Sbjct: 1429 VEDLMRDLERSHTACATLD---KKQRNFDKV----LAEWKQKLDESQAEL----EAAQKE 1477
Query: 237 LSTQEKEMEKLVQGDQDKTEQLEQLKKENDHL---FLSLTEQ-------RKDQKKLEQTV 286
+ E+ K+ ++ +QLE L++EN +L LTEQ ++ +K ++ V
Sbjct: 1478 SRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLV 1537
Query: 287 EQMKQNETTAMKK-QQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSR 344
EQ K + A+++ + L E + + E + + L R+ + E + LKR + R
Sbjct: 1538 EQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQR 1596
Score = 50.1 bits (118), Expect = 4e-06
Identities = 54/227 (23%), Positives = 105/227 (46%), Gaps = 20/227 (8%)
Query: 131 EDILVVTTQGEVEEIEQHNK--ELCKENQELKDSCISLQKQNSDMQA-------ELQKKQ 181
+D+ + T+ E E+ NK L +E L+++ L K+ +Q +LQ ++
Sbjct: 959 DDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE 1018
Query: 182 EELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQE 241
+++ L IN KLE +Q D E L Q K+ + K+ + Q + E
Sbjct: 1019 DKVNGLIKINAKLE----QQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLE 1074
Query: 242 KEMEKLVQGDQDKTEQLEQLK-KENDHLFLSLTEQRKD---QKKLEQTVEQMKQNETTAM 297
+ +++ + + K +L QL+ K +D SL Q+K Q ++E+ E+++ T
Sbjct: 1075 NDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRA 1134
Query: 298 ---KKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
K++ +L E ++S+RL E +A ++ E E ++R+
Sbjct: 1135 KIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRD 1181
Score = 49.3 bits (116), Expect = 7e-06
Identities = 45/205 (21%), Positives = 97/205 (47%), Gaps = 33/205 (16%)
Query: 166 LQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEK 225
L++Q D++ L+++++ L+ +KLE +K ++ ++ L+ Q++ + +K
Sbjct: 1031 LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQE----SIMDLENDKQQIEEKLKK 1086
Query: 226 MGIRVDQLQAQLSTQE---KEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKD-QKK 281
+ QLQA++ ++ + +K ++ Q + E+LE+ + L + +QR D ++
Sbjct: 1087 KEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE 1146
Query: 282 LEQTVEQMKQ--NETTAM-----KKQQELMDENFDLSKRLSENEIIC------------- 321
LE+ E++++ T+A K++ E DL + ++E
Sbjct: 1147 LEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAE 1206
Query: 322 -----NALQRQKERLEGENDLLKRE 341
+ LQR K++LE E LK E
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSELKME 1231
Score = 47.0 bits (110), Expect = 4e-05
Identities = 47/246 (19%), Positives = 113/246 (45%), Gaps = 23/246 (9%)
Query: 124 QFRPENEEDILVVTTQGEVEEIEQHNKELCKEN-QELKDSCISLQKQNSDMQAELQKKQE 182
+ + + EE+ + +H+ +L +E +E +++ LQ+ S +E+ + +
Sbjct: 1318 ELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRT 1377
Query: 183 ELET--------LQSINKKLELKVKEQKDYWET---ELLQLKEQNQKMSSENEKMGIRVD 231
+ ET L+ KKL +++E ++ ET + L++ Q++ E E + ++
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLE 1437
Query: 232 QLQ---AQLSTQEKEMEKLVQGDQDKTEQ----LEQLKKENDHLFLSLTEQRKDQKKLEQ 284
+ A L +++ +K++ + K ++ LE +KE+ L L + R +++
Sbjct: 1438 RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVD 1497
Query: 285 TVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKE----RLEGENDLLKR 340
+E +++ ++ +L ++ + K L E E ++++K LE L+
Sbjct: 1498 QLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH 1557
Query: 341 ENSRLL 346
E S++L
Sbjct: 1558 EESKIL 1563
Score = 44.7 bits (104), Expect = 2e-04
Identities = 39/207 (18%), Positives = 99/207 (47%), Gaps = 16/207 (7%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQK 202
EE+ + L +EN+ L++ L +Q ++ LQ+ ++ + ++ L++ ++E +
Sbjct: 1493 EEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVE 1552
Query: 203 ---DYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLE 259
++ E+++L+++ + ++ SE ++ I D+ QL + + +Q D
Sbjct: 1553 GSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLD-----A 1607
Query: 260 QLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEI 319
+++ ND L L +KK+E + +M+ + ++ E + +L ++++
Sbjct: 1608 EIRSRNDALRL--------KKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQL 1659
Query: 320 ICNALQRQKERLEGENDLLKRENSRLL 346
+ R E L+ + +++R N LL
Sbjct: 1660 HLDDALRSNEDLKEQLAIVERRNGLLL 1686
Score = 35.4 bits (80), Expect = 0.11
Identities = 36/166 (21%), Positives = 77/166 (46%), Gaps = 10/166 (6%)
Query: 173 MQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVD- 231
M+ E +K E +++ I + + + W ++K + +E E ++ D
Sbjct: 801 MRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEMATMKEDF 860
Query: 232 ----QLQAQLSTQEKEME-KLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTV 286
+ A+ + KE+E K+V Q+K + Q++ E ++L + E+R + + +
Sbjct: 861 ERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDA--EERCEGLIKSKIL 918
Query: 287 EQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLE 332
+ K E T +++E M+ KR E++ C++L+R + LE
Sbjct: 919 LEAKVKELTERLEEEEEMNSELVAKKRNLEDK--CSSLKRDIDDLE 962
Score = 30.4 bits (67), Expect = 3.4
Identities = 23/132 (17%), Positives = 61/132 (46%), Gaps = 4/132 (3%)
Query: 138 TQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAE-LQKKQEELETLQSINKKLEL 196
T +E ++++ ++ K+ Q D L + Q + L+ + ELE + +K
Sbjct: 1779 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGA 1838
Query: 197 KVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTE 256
+ + +E ++ ++ Q ++ ++ VD+LQA++ + +++ E + ++
Sbjct: 1839 EALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAE---EAEEQANT 1895
Query: 257 QLEQLKKENDHL 268
QL + ++ L
Sbjct: 1896 QLSRCRRVQHEL 1907
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 63.2 bits (152), Expect = 5e-10
Identities = 51/249 (20%), Positives = 116/249 (46%), Gaps = 29/249 (11%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKE 200
E+++ ++H K Q ++ + L + + Q E+Q +E E ++ + + L+++ +
Sbjct: 1549 ELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQ 1608
Query: 201 QKDYWETELLQLKEQNQK---------MSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGD 251
K+ + + ++KE +K ++ EKM ++ L+ Q TQ+ +E +
Sbjct: 1609 LKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM-CEIEHLKEQFETQKLNLENI---- 1663
Query: 252 QDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTV--------EQMKQNETTAMKKQQEL 303
+ + +L Q+ EN S+T++R D + +E+T+ E +++ T ++KQ+EL
Sbjct: 1664 ETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEEL 1723
Query: 304 MDENFDLSKRLSENEII-------CNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSL 356
+ L + + + N + ++ LE ND LK ++ ++ + + L
Sbjct: 1724 KIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHL 1783
Query: 357 PYQVPTSDE 365
Q T D+
Sbjct: 1784 KEQQETIDK 1792
Score = 60.5 bits (145), Expect = 3e-09
Identities = 50/230 (21%), Positives = 112/230 (48%), Gaps = 18/230 (7%)
Query: 135 VVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKL 194
++T + +V E ++ E+ + +++KD ++L K + QK E LE ++S+ K+
Sbjct: 1832 LITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKER 1891
Query: 195 ELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDK 254
+ ++ ++ + E QLKE Q+ + + ++ + + ++ ++KL + +K
Sbjct: 1892 D-NLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEK 1950
Query: 255 TEQLEQLKKE----NDHLFLSLTEQRKDQKKLEQTVEQM-----KQNETTAMKKQQELMD 305
T Q+ ++K+ D L + E +K + +L + E + K NE +KKQ E +
Sbjct: 1951 TIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQN 2010
Query: 306 --------ENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLS 347
+NF L+K+L E+ + ++++ L + LK E + ++
Sbjct: 2011 LSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIA 2060
Score = 55.1 bits (131), Expect = 1e-07
Identities = 43/201 (21%), Positives = 97/201 (48%), Gaps = 9/201 (4%)
Query: 152 LCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQ 211
L K QE D S+ K+ D+Q + Q E + L+ K++ K E ++ +
Sbjct: 1426 LSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCC 1485
Query: 212 LKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLS 271
LKEQ + ++ ++ + + + + ++ST +K++E + Q+K +++ +KE
Sbjct: 1486 LKEQEETIN----ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEI--YEKEEQFNIKQ 1539
Query: 272 LTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIIC---NALQRQK 328
++E ++ +L+Q E K ++ + ++++ L + E +I+ ++R +
Sbjct: 1540 ISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQ 1599
Query: 329 ERLEGENDLLKRENSRLLSYM 349
E L+ E D LK +++ M
Sbjct: 1600 EALQIERDQLKENTKEIVAKM 1620
Score = 54.7 bits (130), Expect = 2e-07
Identities = 50/239 (20%), Positives = 105/239 (43%), Gaps = 19/239 (7%)
Query: 124 QFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEE 183
Q EN E++ VT E +++ + L E +LK++ ++ + Q EL+
Sbjct: 1672 QILHENLEEMRSVTK--ERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMH 1729
Query: 184 LETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKE 243
L+ Q KL V E+ + L+ N + +++ K+ + L Q++
Sbjct: 1730 LKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQET 1789
Query: 244 MEKLVQGDQDKTEQLEQLKKE-----------------NDHLFLSLTEQRKDQKKLEQTV 286
++KL +KT++L ++K+ N+H ++L + + +K +
Sbjct: 1790 IDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM 1849
Query: 287 EQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
EQ+K+ +L EN +L+++L EN ++ ++++ L + LK E +L
Sbjct: 1850 EQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQL 1908
Score = 50.1 bits (118), Expect = 4e-06
Identities = 44/203 (21%), Positives = 101/203 (49%), Gaps = 11/203 (5%)
Query: 165 SLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLK-EQNQKMSSEN 223
+++ + + ++A+ + E L++ +++ELK+KE+ D E E L+ K +++Q+M +
Sbjct: 495 NIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIH 554
Query: 224 EKMGIRVDQLQAQLSTQ--EKEMEKLVQGDQDKTEQLEQL-------KKENDHLFLSLT- 273
E ++ A++ Q E E+ V+ ++K +Q+++L K EN + LS +
Sbjct: 555 EISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSL 614
Query: 274 EQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEG 333
E +D K+++QT+ + A ++ L EN +L +++ E ++ + +
Sbjct: 615 ESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQS 674
Query: 334 ENDLLKRENSRLLSYMGLDFNSL 356
+ + K+ L + FN +
Sbjct: 675 QLEAKKKMQVDLEKELQSAFNEI 697
Score = 50.1 bits (118), Expect = 4e-06
Identities = 51/199 (25%), Positives = 97/199 (48%), Gaps = 12/199 (6%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQK 202
+E ++ K L KE LK +L+ ++ ++ +++ +++ QS ++ L +KE K
Sbjct: 1338 QESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQS-KQEQSLNMKE-K 1395
Query: 203 DYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLK 262
D T+++ EQ + S ++ I + L +L EM+ + + D E L+
Sbjct: 1396 DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQ 1455
Query: 263 KENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICN 322
E+D L ++ E K +T E++K +K+Q+E ++E L LSE E +
Sbjct: 1456 SESDQLKENIKE---IVAKHLETEEELKVAH-CCLKEQEETINE---LRVNLSEKETEIS 1508
Query: 323 ALQRQKERLEGENDLLKRE 341
+Q+Q LE ND L+ +
Sbjct: 1509 TIQKQ---LEAINDKLQNK 1524
Score = 49.7 bits (117), Expect = 5e-06
Identities = 41/215 (19%), Positives = 103/215 (47%), Gaps = 14/215 (6%)
Query: 130 EEDILVVTTQGEVEEIEQHNKELCKENQEL------KDSCIS----LQKQNSDMQAELQK 179
EE IL+ + E+E+ KE+ +++EL KD S + + + E+ K
Sbjct: 741 EEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGK 800
Query: 180 KQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLST 239
+++L T QS K + + + K T + +++ + + ENE+M + L +
Sbjct: 801 TKDDLATTQSNYKSTDQEFQNFK----TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQK 856
Query: 240 QEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKK 299
+ + L KT++L++ +E + + ++ + + T++ +++ +T +K
Sbjct: 857 FDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEK 916
Query: 300 QQELMDENFDLSKRLSENEIICNALQRQKERLEGE 334
Q+ ++E L++ + + + +LQ ++++L+ +
Sbjct: 917 LQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSD 951
Score = 45.4 bits (106), Expect = 1e-04
Identities = 44/228 (19%), Positives = 115/228 (50%), Gaps = 26/228 (11%)
Query: 128 ENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETL 187
+ ++D+ TQ +++ + E+ ++ +++ SL ++ +++Q L+ E E L
Sbjct: 1016 DKKQDLEAKNTQTLTADVKDN--EIIEQQRKI----FSLIQEKNELQQMLESVIAEKEQL 1069
Query: 188 QS-INKKLELKVKEQKDYWETELL--QLKEQNQKMSSENEKMGIRVDQLQA---QLSTQE 241
++ + + +E+ ++ Q+ E LL +LK+Q + ++ E + +L +L+ E
Sbjct: 1070 KTDLKENIEMTIENQE---ELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVE 1126
Query: 242 KEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQ 301
+++++ Q Q+K +QL +++E ++E +K ++E ++K E T +
Sbjct: 1127 EKLKEKSQQLQEKQQQLLNVQEE-------MSEMQKKINEIENLKNELKNKELTL----E 1175
Query: 302 ELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYM 349
+ E +L+++L+EN ++ ++++ L+ + E L Y+
Sbjct: 1176 HMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYI 1223
Score = 44.3 bits (103), Expect = 2e-04
Identities = 45/223 (20%), Positives = 104/223 (46%), Gaps = 19/223 (8%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
QG +EEI + +L K + Q + QK + LE + +N+++
Sbjct: 792 QGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLS 851
Query: 199 KEQKDY------WETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQ 252
KE + + +TEL ++ Q+ + E ++ ++QL+ QL ++ ++ + +
Sbjct: 852 KEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKT 911
Query: 253 DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSK 312
TE+L+Q +E +LT+++ D K+L+++++ +++ Q D + ++
Sbjct: 912 LITEKLQQTLEE----VKTLTQEKDDLKQLQESLQ---------IERDQLKSDIHDTVNM 958
Query: 313 RLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNS 355
+ E + NAL+ K+ E N L + + + + ++ N+
Sbjct: 959 NIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENT 1001
Score = 42.7 bits (99), Expect = 7e-04
Identities = 59/254 (23%), Positives = 103/254 (40%), Gaps = 43/254 (16%)
Query: 124 QFRPENEEDILVVTTQGEVEEIE--------QHNKELCKENQELKDSCISLQKQNSDMQA 175
Q R E EE L + + +++E E +L E LK+ + N D++
Sbjct: 516 QLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLEN 575
Query: 176 ELQKKQEELETLQSINKKLELKVKEQK--------DY-----------------WETELL 210
EL K E L + KKL+ + QK Y ET L
Sbjct: 576 ELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVAL 635
Query: 211 QLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFL 270
K ++ + SEN + + + +L+T K+ME +Q Q QLE KK L
Sbjct: 636 DAKRESAFLRSEN----LELKEKMKELATTYKQMENDIQLYQ---SQLEAKKKMQVDLEK 688
Query: 271 SLTEQRKDQKKLEQTVE-QMKQNETTAMKKQQELMDENFDLSKRLSENEIICN--ALQRQ 327
L + KL ++ ++ ++ ++ + ++ D +L+K + ENE + L +
Sbjct: 689 ELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSE 748
Query: 328 KERLEGENDLLKRE 341
+ L E + L++E
Sbjct: 749 LKSLPSEVERLRKE 762
Score = 40.0 bits (92), Expect = 0.004
Identities = 47/210 (22%), Positives = 95/210 (45%), Gaps = 30/210 (14%)
Query: 137 TTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLEL 196
T + ++ E N + + E KD Q++ + + + + +TL + K E+
Sbjct: 982 TLKSKISEEVSRNLHMEENTGETKDE---FQQKMVGIDKKQDLEAKNTQTLTADVKDNEI 1038
Query: 197 KVKEQKDYW----ETELLQL-------KEQNQKMSSENEKMGIRVDQLQAQLSTQEKEME 245
+++K + + EL Q+ KEQ + EN +M T E + E
Sbjct: 1039 IEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM------------TIENQEE 1086
Query: 246 KLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELM- 304
+ GD+ K +Q E + +E +H E + +L + E++K+ +KQQ+L+
Sbjct: 1087 LRLLGDELKKQQ-EIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLN 1145
Query: 305 --DENFDLSKRLSENEIICNALQRQKERLE 332
+E ++ K+++E E + N L+ ++ LE
Sbjct: 1146 VQEEMSEMQKKINEIENLKNELKNKELTLE 1175
Score = 40.0 bits (92), Expect = 0.004
Identities = 43/199 (21%), Positives = 92/199 (46%), Gaps = 24/199 (12%)
Query: 157 QELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQN 216
+EL++S ++ ++++ K Q+ELE I KL+ KV E N
Sbjct: 2384 RELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKV--------------HESN 2429
Query: 217 QKMSSENEKMGIRVDQLQAQLSTQEKEME----KLVQGDQDKTEQLEQLKKENDHLFLSL 272
+ + E + + D++ ++E+E KLV+ D +K + ++ +KE ++
Sbjct: 2430 KCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATV 2489
Query: 273 TEQRKDQKKLEQTVEQMKQ-NETTAMKKQQELMDENFDLSKRLSENEIICNA----LQRQ 327
Q++ + L + + + +Q +T+ + + + N L+ + I+ N L+ +
Sbjct: 2490 EYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCG-GGSGIVQNTKALILKSE 2548
Query: 328 KERLEGENDLLKRENSRLL 346
RLE E LK++N +L+
Sbjct: 2549 HIRLEKEISKLKQQNEQLI 2567
Score = 39.7 bits (91), Expect = 0.006
Identities = 46/203 (22%), Positives = 99/203 (48%), Gaps = 13/203 (6%)
Query: 144 EIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSI--NKKLELKVKEQ 201
E+ + ++ K+ QE DS L+ D+ L+ ++ + Q++ + + L K +
Sbjct: 582 ELLREKEDQIKKLQEYIDSQ-KLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRE 640
Query: 202 KDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEK---EMEKLVQGDQDKTEQL 258
+ +E L+LKE+ +++++ ++M + Q+QL ++K ++EK +Q ++ +L
Sbjct: 641 SAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKL 700
Query: 259 EQL---KKENDHLF-LSLTEQRKD-QKKLEQTVEQMK--QNETTAMKKQQELMDENFDLS 311
L K D L L L + D QK+L + VE+ + + E + + + L E L
Sbjct: 701 TSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLR 760
Query: 312 KRLSENEIICNALQRQKERLEGE 334
K + + + + +K++L E
Sbjct: 761 KEIQDKSEELHIITSEKDKLFSE 783
Score = 38.9 bits (89), Expect = 0.010
Identities = 44/212 (20%), Positives = 92/212 (43%), Gaps = 41/212 (19%)
Query: 138 TQGEVEEIEQHNKELCKENQELKDSCISLQKQ---NSDMQAELQKKQEEL--------ET 186
T ++ E+E E + + I +QK+ +D+ A+LQ K E ET
Sbjct: 2379 TTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKET 2438
Query: 187 LQSINKKLELKVKEQKDYWET---ELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQE-- 241
+Q + K+ L K K+ E +L+++ + K + E EK ++ A +T E
Sbjct: 2439 IQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEK------EISATKATVEYQ 2492
Query: 242 KEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQ-------------------RKDQKKL 282
KE+ +L++ + +++Q + ++H + + + + +L
Sbjct: 2493 KEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRL 2552
Query: 283 EQTVEQMKQNETTAMKKQQELMDENFDLSKRL 314
E+ + ++KQ +K++ EL+ N LS +
Sbjct: 2553 EKEISKLKQQNEQLIKQKNELLSNNQHLSNEV 2584
Score = 34.7 bits (78), Expect = 0.18
Identities = 35/135 (25%), Positives = 61/135 (45%), Gaps = 16/135 (11%)
Query: 184 LETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKE 243
L+TL I K+ Q++ E+EL L+ + + E QL T+++E
Sbjct: 476 LDTLSEIEWNPATKLLNQENI-ESELNSLRADYDNLVLDYE-----------QLRTEKEE 523
Query: 244 MEKLV--QGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQ 301
ME + + D D+ E LE+ K++ + L + + K L + E Q+ + +
Sbjct: 524 MELKLKEKNDLDEFEALERKTKKDQE--MQLIHEISNLKNLVKHAEVYNQDLENELSSKV 581
Query: 302 ELMDENFDLSKRLSE 316
EL+ E D K+L E
Sbjct: 582 ELLREKEDQIKKLQE 596
Score = 32.7 bits (73), Expect = 0.68
Identities = 36/190 (18%), Positives = 77/190 (40%), Gaps = 40/190 (21%)
Query: 145 IEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDY 204
I++ N +C+ N + I++ ++++ + E +I+K+
Sbjct: 2289 IQKENDRICQVNNFFNNRIIAIMNESTEFE----------ERSATISKE----------- 2327
Query: 205 WETELLQLKEQNQKMSSENEKMGIRV-DQLQAQLSTQE-KEMEKLVQGDQDKTEQLEQLK 262
WE +L LKE+N+K+ + + + Q +TQ+ K + Q TE++ +L
Sbjct: 2328 WEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIREL- 2386
Query: 263 KENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICN 322
+ L + E E+ +K Q+EL N ++K ++
Sbjct: 2387 ----------------ENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNK 2430
Query: 323 ALQRQKERLE 332
L++ KE ++
Sbjct: 2431 CLEKTKETIQ 2440
Score = 30.4 bits (67), Expect = 3.4
Identities = 34/133 (25%), Positives = 64/133 (48%), Gaps = 9/133 (6%)
Query: 205 WETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKE 264
+ E++ LK+Q +++S E + DQL AQL +EK++ + VQ +K E L ++
Sbjct: 348 YRKEIMDLKKQLEEVSLETRAQAMEKDQL-AQL-LEEKDLLQKVQ--NEKIENLTRMLVT 403
Query: 265 NDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNAL 324
+ L+L ++ K ++K T K N+ MK N + +++ N L
Sbjct: 404 SSS--LTLQQELKAKRKRRVTWCLGKINK---MKNSNYADQFNIPTNITTKTHKLSINLL 458
Query: 325 QRQKERLEGENDL 337
+ E + E+D+
Sbjct: 459 REIDESVCSESDV 471
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 62.8 bits (151), Expect = 6e-10
Identities = 41/205 (20%), Positives = 114/205 (55%), Gaps = 15/205 (7%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQK--KQEELETLQSINKKLELKVKE 200
EE + H +E E ++ ++ + +Q ++ + +K +QEE I ++ E + ++
Sbjct: 549 EEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEE-----KIREQEEKRQEQ 603
Query: 201 QKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQ 260
++ W+ E +++EQ +K+ + EK+ + ++++ Q +++ EK+ + ++ EQ E+
Sbjct: 604 EEKMWKQEE-KIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK 662
Query: 261 LKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEII 320
++++ + ++ + R+ +KK+ + E++++ E M++Q+E M ++ +++ E E
Sbjct: 663 MQEQEETMWRQEEKIREQEKKIREQEEKIREQE-EMMQEQEEKM---WEQEEKMCEQE-- 716
Query: 321 CNALQRQKERLEGENDLLKRENSRL 345
+Q Q+E++ + + + + RL
Sbjct: 717 -EKMQEQEEKMRRQEEKMWEQEVRL 740
Score = 62.8 bits (151), Expect = 6e-10
Identities = 43/190 (22%), Positives = 105/190 (55%), Gaps = 18/190 (9%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQK 202
E+I + +++ ++ +++++ Q+Q M + +K +E+ E +Q + E K++EQ+
Sbjct: 577 EKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQ----EQEEKIREQE 632
Query: 203 DYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLK 262
+ + +EQ +KM + EKM + +++Q Q T ++ EK+ + ++ EQ E+++
Sbjct: 633 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIR 692
Query: 263 KENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICN 322
++ + + Q +++K EQ + +Q E M++Q+E M +++ E E+
Sbjct: 693 EQEEMM------QEQEEKMWEQEEKMCEQEE--KMQEQEEKMRRQ---EEKMWEQEV--- 738
Query: 323 ALQRQKERLE 332
L++Q+E+++
Sbjct: 739 RLRQQEEKMQ 748
Score = 60.5 bits (145), Expect = 3e-09
Identities = 51/229 (22%), Positives = 110/229 (48%), Gaps = 14/229 (6%)
Query: 123 FQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQE 182
++F E E+ + V TQ + + +++ +EL KE L + +++ + K QE
Sbjct: 171 WKFAGELEQALSAVATQKK--KADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE 228
Query: 183 ELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEK 242
+L+ ++S +++L VKE K E L L + Q++ +E + +G + + A+L Q +
Sbjct: 229 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQ--QQLQAEADHLGKELQSVSAKLQAQVE 286
Query: 243 E----------MEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQN 292
E E+ + ++K ++ E+ +E + E+ ++Q++ + E+M
Sbjct: 287 ENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWE 346
Query: 293 ETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
+ M++Q+E+M E + +R E R++E + E + RE
Sbjct: 347 KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE 395
Score = 59.7 bits (143), Expect = 5e-09
Identities = 39/212 (18%), Positives = 113/212 (53%), Gaps = 18/212 (8%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQK 202
E+I + +++ ++ +++++ +++Q M + +K +E+ E + E K+ EQ+
Sbjct: 503 EKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWRE-----EEKMHEQE 557
Query: 203 DYWETELLQLKE-----QNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQ 257
WE E Q +E Q +K+ + EK+ + ++++ Q ++++ EK+ + ++ EQ
Sbjct: 558 KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQ 617
Query: 258 LEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDL----SKR 313
E+++++ + + E+ ++Q+++ Q E+ + M +Q+E M E + ++
Sbjct: 618 EEKIQEQEEKI-REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEK 676
Query: 314 LSENEIICNALQRQKERLEGENDLLKRENSRL 345
+ E E ++ Q+E++ + ++++ + ++
Sbjct: 677 IREQE---KKIREQEEKIREQEEMMQEQEEKM 705
Score = 57.0 bits (136), Expect = 3e-08
Identities = 41/223 (18%), Positives = 112/223 (50%), Gaps = 19/223 (8%)
Query: 139 QGEVEEIEQHNKELCKE---------NQELKDSCISLQKQNSDMQAELQKKQEELETLQS 189
+ E EI+ + KEL ++ Q+L+ L K+ + A+LQ + EE E
Sbjct: 234 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR 293
Query: 190 INKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQ 249
+N++ E K+ Q++ + +++EQ +K+ + EK+ + ++++ Q ++ EK+ +
Sbjct: 294 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 353
Query: 250 GDQDKTEQLEQLKKENDHLFLSLTEQRKD-------QKKLEQTVEQMKQNETTAMKKQQE 302
++ E+ E+++++ + ++ + R+ ++K+ + E+M + E ++++
Sbjct: 354 QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKR 413
Query: 303 LMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRL 345
+E ++ E E + RQ+E++ + + ++ + ++
Sbjct: 414 QEEEKIREQEKRQEQEA---KMWRQEEKIREQEEKIREQEKKM 453
Score = 51.2 bits (121), Expect = 2e-06
Identities = 42/215 (19%), Positives = 113/215 (52%), Gaps = 18/215 (8%)
Query: 128 ENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSC-ISLQKQNSDMQAELQKKQEELET 186
E EE I + +E + H +E +E ++ ++ + Q++ Q E+ +++E++
Sbjct: 441 EQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHE 500
Query: 187 LQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEK 246
+ +K E KV Q++ + +++EQ +KM + EK+ + Q ++ +E++M
Sbjct: 501 QEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKI-----REQEEMWREEEKMH- 554
Query: 247 LVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDE 306
+Q+K + E+ +++ D ++ + R+ ++K+ + E++++ E +K+QE ++
Sbjct: 555 ----EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQE----EKRQEQEEK 606
Query: 307 NFDLSKRLSENEIICNALQRQKERLEGENDLLKRE 341
+ +++ E E +Q Q+E++ + + ++ +
Sbjct: 607 MWKQEEKIREQE---EKIQEQEEKIREQEEKIREQ 638
Score = 50.4 bits (119), Expect = 3e-06
Identities = 37/219 (16%), Positives = 112/219 (51%), Gaps = 18/219 (8%)
Query: 141 EVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQK-------KQEELETLQSINKK 193
E E+ ++ ++ ++ +++++ +++Q M + +K ++EE Q +
Sbjct: 421 EQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR 480
Query: 194 LELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQD 253
E K+ EQ++ W + ++ EQ +K+ + EK+ + ++++ Q ++ EK+ + ++
Sbjct: 481 QEEKIHEQEEIWR-QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEK 539
Query: 254 KTEQLEQLKKEND-HLFLSLTEQRKDQK---KLEQTVEQMKQNETTAMKKQQELMDENFD 309
EQ E ++E H + E+ K Q+ K+ + E++++ E ++++++ ++
Sbjct: 540 IREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQE-- 597
Query: 310 LSKRLSENEIIC---NALQRQKERLEGENDLLKRENSRL 345
KR + E + ++ Q+E+++ + + ++ + ++
Sbjct: 598 -EKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKI 635
Score = 49.7 bits (117), Expect = 5e-06
Identities = 33/213 (15%), Positives = 114/213 (53%), Gaps = 17/213 (7%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAE---LQKKQEELETLQSINKKLELKVK 199
E+I++ +++ ++ +++++ +++Q M+ + + +K+E++ + + + E K++
Sbjct: 307 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366
Query: 200 EQKDY-WETELLQLK------EQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQ 252
Q++ WE E + E+ +K+ EKM +Q + + ++++ E+ ++ +
Sbjct: 367 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH---EQEKIREQEEKRQEEEKIREQE 423
Query: 253 DKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSK 312
+ EQ ++ ++ + + + R+ +KK+ + E++ + E +++++ +E + +
Sbjct: 424 KRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE 483
Query: 313 RLSENEIICNALQRQKERLEGENDLLKRENSRL 345
++ E E + RQKE++ + + ++++ ++
Sbjct: 484 KIHEQE----EIWRQKEKMHEQEEKIRKQEEKV 512
Score = 48.5 bits (114), Expect = 1e-05
Identities = 43/213 (20%), Positives = 109/213 (51%), Gaps = 29/213 (13%)
Query: 139 QGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKV 198
Q +VEE E N+ NQ+ ++ +++ + + ++Q+++E++ + ++ E K+
Sbjct: 282 QAQVEENELWNRL----NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM 337
Query: 199 KEQKDY-WETELLQLK------EQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGD 251
+ Q++ WE E + E+ +KM + E M + ++++ Q E+++
Sbjct: 338 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ--------EEMMWEK 389
Query: 252 QDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLS 311
++K +LE+ E + + E+R++++K+ + ++ +Q + M +Q+E + E
Sbjct: 390 EEKIRELEEKMHEQEKI-REQEEKRQEEEKIRE--QEKRQEQEAKMWRQEEKIREQ---E 443
Query: 312 KRLSENEIICNALQRQKERLEGENDLLKRENSR 344
+++ E E + RQ+E++ E + ++ E R
Sbjct: 444 EKIREQE---KKMWRQEEKIH-EQEKIREEEKR 472
Score = 48.5 bits (114), Expect = 1e-05
Identities = 32/139 (23%), Positives = 74/139 (53%), Gaps = 8/139 (5%)
Query: 128 ENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETL 187
E EE I Q + E+I + +++ ++ + ++ + +Q M + +K QE+ ET+
Sbjct: 616 EQEEKI-----QEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM 670
Query: 188 QSINKKL---ELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEM 244
+K+ E K++EQ++ + ++EQ +KM + EKM + +++Q Q ++
Sbjct: 671 WRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 730
Query: 245 EKLVQGDQDKTEQLEQLKK 263
EK+ + + +Q E++++
Sbjct: 731 EKMWEQEVRLRQQEEKMQE 749
Score = 48.1 bits (113), Expect = 2e-05
Identities = 38/203 (18%), Positives = 101/203 (49%), Gaps = 11/203 (5%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKL-ELKVKEQ 201
EE+ +E + +E+ ++ +M E ++K ELE +K+ E + K Q
Sbjct: 355 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 414
Query: 202 KDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQL 261
++ E + +EQ KM + EK+ + ++++ Q ++ EK+ + ++ + E+ Q
Sbjct: 415 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQE 474
Query: 262 KKENDHLFLSLTEQR---KDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENE 318
++E + EQ + ++K+ + E++++ E ++++++ ++ +++ E E
Sbjct: 475 QEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQ----EEKIREQE 530
Query: 319 IICNALQRQKERLEGENDLLKRE 341
+ RQ+E++ + ++ + E
Sbjct: 531 ---EKMWRQEEKIREQEEMWREE 550
Score = 46.6 bits (109), Expect = 5e-05
Identities = 30/172 (17%), Positives = 91/172 (52%), Gaps = 26/172 (15%)
Query: 143 EEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQK 202
E+ ++ +++ K+ +++++ +Q+Q + ++++++E++ + + ++ E K+ EQ+
Sbjct: 598 EKRQEQEEKMWKQEEKIREQEEKIQEQ----EEKIREQEEKIREQEEMTQEQEEKMGEQE 653
Query: 203 DYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLK 262
+ + +++EQ + M + EK+ +E EK ++ ++K + E++
Sbjct: 654 EKMCEQEEKMQEQEETMWRQEEKI---------------REQEKKIREQEEKIREQEEMM 698
Query: 263 KENDHLFLSLTEQRKDQ-KKLEQTVEQMKQNE------TTAMKKQQELMDEN 307
+E + E+ +Q +K+++ E+M++ E +++Q+E M E+
Sbjct: 699 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEH 750
Score = 35.8 bits (81), Expect = 0.081
Identities = 35/138 (25%), Positives = 64/138 (46%), Gaps = 11/138 (7%)
Query: 214 EQNQKMSSENEKMGIRVDQLQAQLST------QEKEMEKLVQGDQDKTEQLEQLKKENDH 267
E QK S ++++ R +L+AQ+ T Q+ E++ + Q +QLE ++
Sbjct: 108 EDEQKASHQHQEALRR--ELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARD--- 162
Query: 268 LFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQ 327
L L + K +LEQ + + + A + +EL E LS L N I L+ +
Sbjct: 163 LISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEK 222
Query: 328 KERLEGENDLLKRENSRL 345
+L+ + L++ E S +
Sbjct: 223 NAKLQEKLQLVESEKSEI 240
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,426,687
Number of Sequences: 37866
Number of extensions: 867264
Number of successful extensions: 15057
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 659
Number of HSP's successfully gapped in prelim test: 1020
Number of HSP's that attempted gapping in prelim test: 4653
Number of HSP's gapped (non-prelim): 6035
length of query: 446
length of database: 18,247,518
effective HSP length: 105
effective length of query: 341
effective length of database: 14,271,588
effective search space: 4866611508
effective search space used: 4866611508
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.