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Search of human proteins with 5031887
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5031887 LIM domain containing preferred translocation
partner in lipoma [Homo sapiens]
(612 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5031887 LIM domain containing preferred translocation partner... 1318 0.0
gi|91208423 thyroid receptor-interacting protein 6 [Homo sapiens] 407 e-113
gi|58530845 zyxin [Homo sapiens] 357 1e-98
gi|4508047 zyxin [Homo sapiens] 357 1e-98
gi|122937269 Wilms tumor 1 interacting protein [Homo sapiens] 243 5e-64
gi|7657307 LIM domains containing 1 [Homo sapiens] 241 1e-63
gi|14249622 ajuba isoform 1 [Homo sapiens] 233 3e-61
gi|66932982 filamin-binding LIM protein-1 isoform a [Homo sapiens] 196 7e-50
gi|66932988 filamin-binding LIM protein-1 isoform c [Homo sapiens] 188 1e-47
gi|37675280 ajuba isoform 2 [Homo sapiens] 148 2e-35
gi|66932986 filamin-binding LIM protein-1 isoform b [Homo sapiens] 117 2e-26
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens] 108 2e-23
gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens] 99 1e-20
gi|54112385 four and a half LIM domains 3 [Homo sapiens] 94 3e-19
gi|109638745 transforming growth factor beta 1 induced transcrip... 91 3e-18
gi|21361591 transforming growth factor beta 1 induced transcript... 91 3e-18
gi|170932514 paxillin isoform 1 [Homo sapiens] 85 2e-16
gi|170932518 paxillin isoform 3 [Homo sapiens] 84 3e-16
gi|170932516 paxillin isoform 2 [Homo sapiens] 84 3e-16
gi|221316659 leupaxin isoform 1 [Homo sapiens] 84 4e-16
gi|4758670 leupaxin isoform 2 [Homo sapiens] 84 4e-16
gi|87159836 four and a half LIM domains 2 [Homo sapiens] 84 5e-16
gi|87159834 four and a half LIM domains 2 [Homo sapiens] 84 5e-16
gi|42403575 four and a half LIM domains 2 [Homo sapiens] 84 5e-16
gi|87159832 four and a half LIM domains 2 [Homo sapiens] 84 5e-16
gi|30410801 activator of cAMP-responsive element modulator (CREM... 81 3e-15
gi|7662330 actin binding LIM protein family, member 3 [Homo sapi... 80 5e-15
gi|51173715 actin-binding LIM protein 1 isoform c [Homo sapiens] 77 4e-14
gi|51173713 actin-binding LIM protein 1 isoform b [Homo sapiens] 77 4e-14
gi|51173711 actin-binding LIM protein 1 isoform a [Homo sapiens] 77 4e-14
>gi|5031887 LIM domain containing preferred translocation partner in
lipoma [Homo sapiens]
Length = 612
Score = 1318 bits (3412), Expect = 0.0
Identities = 612/612 (100%), Positives = 612/612 (100%)
Query: 1 MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQ 60
MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQ
Sbjct: 1 MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQ 60
Query: 61 PGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAE 120
PGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAE
Sbjct: 61 PGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAE 120
Query: 121 IDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTL 180
IDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTL
Sbjct: 121 IDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTL 180
Query: 181 KPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSS 240
KPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSS
Sbjct: 181 KPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSS 240
Query: 241 GQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGY 300
GQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGY
Sbjct: 241 GQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGY 300
Query: 301 YAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPV 360
YAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPV
Sbjct: 301 YAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPV 360
Query: 361 SAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPADEYFGRCARCG 420
SAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPADEYFGRCARCG
Sbjct: 361 SAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPADEYFGRCARCG 420
Query: 421 ENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCS 480
ENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCS
Sbjct: 421 ENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCS 480
Query: 481 KPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCK 540
KPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCK
Sbjct: 481 KPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCK 540
Query: 541 EPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSAR 600
EPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSAR
Sbjct: 541 EPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSAR 600
Query: 601 IRVLTAKASTDL 612
IRVLTAKASTDL
Sbjct: 601 IRVLTAKASTDL 612
>gi|91208423 thyroid receptor-interacting protein 6 [Homo sapiens]
Length = 476
Score = 407 bits (1046), Expect = e-113
Identities = 257/600 (42%), Positives = 309/600 (51%), Gaps = 147/600 (24%)
Query: 34 ISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPP 93
+S T PPK+ P AP+ + P PG PPP ++ P NF P P
Sbjct: 1 MSGPTWLPPKQPEPARAPQGRAIPRGTPG---------PPPAHGAALQPHPRVNFCPLP- 50
Query: 94 LDEEAFKVQGNPGGK---------TLEE-----------RRSSLDAEIDSLTSILADLEC 133
E+ ++ G P + L+ R SLDAEID L+S LA+L
Sbjct: 51 -SEQCYQAPGGPEDRGPAWVGSHGVLQHTQGLPADRGGLRPGSLDAEIDLLSSTLAELNG 109
Query: 134 SSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPV 193
+ R P PP A + +LKP PA P+P
Sbjct: 110 GRGHASRRPDRQAYEPPPPP--------------------AYRTGSLKPNPA---SPLPA 146
Query: 194 APIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNT 253
+P G P PASYTTAST + P F VQVK AQP
Sbjct: 147 SPYGG------PTPASYTTASTPAGPAFPVQVKVAQP----------------------- 177
Query: 254 QPVPVSGQCPPPSTRGGMDYAYIPPPGLQ-PEPGYGYAPNQGRYYEGYYAAGPGYGGRND 312
V G C PP R G A P PG P PG G GPGY R+
Sbjct: 178 ----VRG-CGPP--RRGASQASGPLPGPHFPLPGRGEV------------WGPGY--RSQ 216
Query: 313 SDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKG 372
+P PG AG P G
Sbjct: 217 REPG-------------PGAKEEAAGVSGPAGR--------------------------- 236
Query: 373 GHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTA 432
G G+ GP V S PEDEL+ LTKK+++DM +PP+ EYFG+C CGE+VVG+G G A
Sbjct: 237 GRGGEHGPQ-VPLSQPPEDELDRLTKKLVHDMNHPPSGEYFGQCGGCGEDVVGDGAGVVA 295
Query: 433 MDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATG 492
+D+VFHV CF C C +LRGQ FYAVE++AYCE CY+ TLE+C CS+PI++RILRA G
Sbjct: 296 LDRVFHVGCFVCSTCRAQLRGQHFYAVERRAYCEGCYVATLEKCATCSQPILDRILRAMG 355
Query: 493 KAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEET 552
KAYHP CFTCV+CHR LDGIPFTVDA IHCIEDFH+KFAPRCSVC IMP PGQEET
Sbjct: 356 KAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGAIMPEPGQEET 415
Query: 553 VRIVALDRDFHVHCYRCEDCGGLL-SEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTD 611
VRIVALDR FH+ CY+CE+CG LL SEG+ QGCYPLDGHILCK C++ RI+ L+A +TD
Sbjct: 416 VRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKACSAWRIQELSATVTTD 475
>gi|58530845 zyxin [Homo sapiens]
Length = 572
Score = 357 bits (917), Expect = 1e-98
Identities = 229/625 (36%), Positives = 310/625 (49%), Gaps = 117/625 (18%)
Query: 31 NPSISVSTQQPP-----KKFAPVVAPKPKYNPYK---------------QPGGEGDFLPP 70
+P+ISVS P KKF PVVAPKPK NP++ Q G G+ PP
Sbjct: 7 SPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRVGEIPPP 66
Query: 71 PP-------PPL--DDSSALPSISGNFPPPPPLDEEAF-----------------KVQGN 104
PP PPL D A ++ G FPPPPP EE+F + +G
Sbjct: 67 PPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPSPPPPPEEEGG 126
Query: 105 PGGKTL-----EERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVT 159
P E+ SS+D EIDSL+S+L D+ + P+K R + PPV+TP +
Sbjct: 127 PEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARV----SSGYVPPPVATPFS 182
Query: 160 GHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQ-PVPASYTTASTSSR 218
KS+ KP A P + +P PQ P PA S+
Sbjct: 183 S----------------KSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQ-------SQ 219
Query: 219 PTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPP 278
F+VQ + QP P S TQPV ++ P RG P
Sbjct: 220 TQFHVQPQP-QPKPQVQLHVQS-----------QTQPVSLANTQP----RG--------P 255
Query: 279 PGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAG 338
P P P ++P ++ PG G + S P + GHP G G
Sbjct: 256 PASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQ-KLGHPEALSA-------GTG 307
Query: 339 NQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTK 398
+ PP +K + + P PP Q + P + + + +ELE LT+
Sbjct: 308 SPQPPSFTYAQQREKPRVQEK-QHPVPPPAQNQNQVRSPGAPGPL--TLKEVEELEQLTQ 364
Query: 399 KMLYDMENPPADEYFGR--CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPF 456
+++ DME+P C RC + + A+ Q+FH+ CFTC C +L+GQ F
Sbjct: 365 QLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQF 424
Query: 457 YAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTV 516
Y++E YCE CY +TLE+CN C +PI +R+LRATGKAYHPHCFTCV+C R L+G F V
Sbjct: 425 YSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIV 484
Query: 517 DAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLL 576
D HC+ D+HK++APRCSVC EPIMP PG++ETVR+VALD++FH+ CY+CEDCG L
Sbjct: 485 DQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPL 544
Query: 577 S-EGDNQGCYPLDGHILCKTCNSAR 600
S E D+ GC+PLDGH+LC+ C++AR
Sbjct: 545 SIEADDNGCFPLDGHVLCRKCHTAR 569
>gi|4508047 zyxin [Homo sapiens]
Length = 572
Score = 357 bits (917), Expect = 1e-98
Identities = 229/625 (36%), Positives = 310/625 (49%), Gaps = 117/625 (18%)
Query: 31 NPSISVSTQQPP-----KKFAPVVAPKPKYNPYK---------------QPGGEGDFLPP 70
+P+ISVS P KKF PVVAPKPK NP++ Q G G+ PP
Sbjct: 7 SPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRVGEIPPP 66
Query: 71 PP-------PPL--DDSSALPSISGNFPPPPPLDEEAF-----------------KVQGN 104
PP PPL D A ++ G FPPPPP EE+F + +G
Sbjct: 67 PPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPSPPPPPEEEGG 126
Query: 105 PGGKTL-----EERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVT 159
P E+ SS+D EIDSL+S+L D+ + P+K R + PPV+TP +
Sbjct: 127 PEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARV----SSGYVPPPVATPFS 182
Query: 160 GHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQ-PVPASYTTASTSSR 218
KS+ KP A P + +P PQ P PA S+
Sbjct: 183 S----------------KSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQ-------SQ 219
Query: 219 PTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPP 278
F+VQ + QP P S TQPV ++ P RG P
Sbjct: 220 TQFHVQPQP-QPKPQVQLHVQS-----------QTQPVSLANTQP----RG--------P 255
Query: 279 PGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAG 338
P P P ++P ++ PG G + S P + GHP G G
Sbjct: 256 PASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQ-KLGHPEALSA-------GTG 307
Query: 339 NQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTK 398
+ PP +K + + P PP Q + P + + + +ELE LT+
Sbjct: 308 SPQPPSFTYAQQREKPRVQEK-QHPVPPPAQNQNQVRSPGAPGPL--TLKEVEELEQLTQ 364
Query: 399 KMLYDMENPPADEYFGR--CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPF 456
+++ DME+P C RC + + A+ Q+FH+ CFTC C +L+GQ F
Sbjct: 365 QLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQF 424
Query: 457 YAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTV 516
Y++E YCE CY +TLE+CN C +PI +R+LRATGKAYHPHCFTCV+C R L+G F V
Sbjct: 425 YSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIV 484
Query: 517 DAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLL 576
D HC+ D+HK++APRCSVC EPIMP PG++ETVR+VALD++FH+ CY+CEDCG L
Sbjct: 485 DQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPL 544
Query: 577 S-EGDNQGCYPLDGHILCKTCNSAR 600
S E D+ GC+PLDGH+LC+ C++AR
Sbjct: 545 SIEADDNGCFPLDGHVLCRKCHTAR 569
>gi|122937269 Wilms tumor 1 interacting protein [Homo sapiens]
Length = 430
Score = 243 bits (619), Expect = 5e-64
Identities = 127/320 (39%), Positives = 174/320 (54%), Gaps = 30/320 (9%)
Query: 290 APNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKR--EPGYTPPGAGNQNPPGMYP 347
+P GR P G S + G +G + PG P A + P G P
Sbjct: 120 SPRSGRSDPRPGPGPPSVGSARSSVSSLGSRGSAGAYADFLPPGACPAPARSPEPAGPAP 179
Query: 348 VTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENP 407
P A PL P G G GPS+ E LE LT+++ +E
Sbjct: 180 FPLP-------------ALPLPP--GREG--GPSAA------ERRLEALTRELERALEAR 216
Query: 408 PADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEP 467
A +YFG C +CG + G C AM ++H DCFTC C +LRG+ FY V +K YC+
Sbjct: 217 TARDYFGICIKCGLGIYGAQQACQAMGSLYHTDCFTCDSCGRRLRGKAFYNVGEKVYCQE 276
Query: 468 CYI-----NTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLI 522
++ T ++C+VC IME IL+A GK+YHP CF C +C+ LDG+PFTVD I
Sbjct: 277 DFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVENNI 336
Query: 523 HCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQ 582
+C+ D+H FAP+C+ C PI+PA G E T+R+V++DRD+HV CY CEDCG LS + +
Sbjct: 337 YCVRDYHTVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVACYHCEDCGLQLSGEEGR 396
Query: 583 GCYPLDGHILCKTCNSARIR 602
CYPL GH+LC+ C+ R++
Sbjct: 397 RCYPLAGHLLCRRCHLRRLQ 416
>gi|7657307 LIM domains containing 1 [Homo sapiens]
Length = 676
Score = 241 bits (615), Expect = 1e-63
Identities = 145/416 (34%), Positives = 207/416 (49%), Gaps = 61/416 (14%)
Query: 224 QVKSAQPSPHYM-AAPSSGQIYGSGPQGYNTQPVPVSGQCPPP-------STRGGMDYAY 275
+V PSP+ AP+ G + P + P++ CP S GG
Sbjct: 270 RVSPGLPSPNLENGAPAVGPVQPRTP----SVSAPLALSCPRQGGLPRSNSGLGGEVSGV 325
Query: 276 IPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPP 335
+ P + P+P + P Y A G + S QQG +PG T
Sbjct: 326 MSKPNVDPQPWFQDGPKS---YLSSSAPSSSPAGLDGS-----QQGAVPGLGPKPGCTDL 377
Query: 336 GAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGG-----HSGQLG------PSSV- 383
G G + P T + PV + P L K G G LG PSS
Sbjct: 378 GTGPKLSP----------TSLVHPVMSTL-PELSCKEGPLGWSSDGSLGSVLLDSPSSPR 426
Query: 384 ----------APSFRP---EDELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGC 430
P RP E +LE LT+++ +M+ P +YFG C +C + V G G C
Sbjct: 427 VRLPCQPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYFGACVKCSKGVFGAGQAC 486
Query: 431 TAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYI-----NTLEQCNVCSKPIME 485
AM ++H CFTC C+ KLRG+ FY V K +CE ++ + ++C +C IM+
Sbjct: 487 QAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMD 546
Query: 486 RILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMP 545
IL+A GK+YHP CF CV+C+ LDG+PFTVD+ I+C+ D+HK AP+C+ C PI+P
Sbjct: 547 MILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILP 606
Query: 546 APGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARI 601
G +ET+R+V++DRD+HV CY CEDCG L++ D CYPL+ H+ C +C+ R+
Sbjct: 607 PEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCHVKRL 662
Score = 40.8 bits (94), Expect = 0.004
Identities = 27/94 (28%), Positives = 43/94 (45%), Gaps = 21/94 (22%)
Query: 415 RCARCGENVVG-EGTGCT----AMDQVFHVDCFTCIICNNKLR---GQPFYAVEKKAYCE 466
+CA CG ++ EG+ T +MD+ +HV+C+ C C +L G Y +E +C
Sbjct: 596 KCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCH 655
Query: 467 PCYINTLEQCNVCSKPIMERILRATGKAYHPHCF 500
C++ LE+ R + A H H F
Sbjct: 656 SCHVKRLEK-------------RPSSTALHQHHF 676
>gi|14249622 ajuba isoform 1 [Homo sapiens]
Length = 538
Score = 233 bits (595), Expect = 3e-61
Identities = 145/448 (32%), Positives = 212/448 (47%), Gaps = 49/448 (10%)
Query: 184 PAPQAGPI-----PVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAP 238
P PQ+ P P AP L P+ +S + AS S P ++ + A + P
Sbjct: 100 PLPQSLPPDFRLEPTAP--ALSPRSSFASSSASDASKPSSPRGSLLLDGAGAGGAGGSRP 157
Query: 239 SSGQIYGSGPQGYNTQ---PVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGR 295
S + G GY+ + P+P P G P G P P
Sbjct: 158 CSNRTSGIS-MGYDQRHGSPLPAGPCLFGPPLAGA-------PAGYSPGGVPSAYPELHA 209
Query: 296 YYEGYYAAGP-GYG---GRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNP-------PG 344
+ YA P G+G R+ P G G G G P PG
Sbjct: 210 ALDRLYAQRPAGFGCQESRHSYPPALGSPG---------ALAGAGVGAAGPLERRGAQPG 260
Query: 345 MYPVTGPKKTYI----TDPVSAPCAPPLQPKGGHSGQLG-PSSVAPSFRPEDELEHLTKK 399
+ VTG + D ++A + G +G G PS + PS E + +
Sbjct: 261 RHSVTGYGDCAVGARYQDELTALLRLTVGTGGREAGARGEPSGIEPSGLEEPPGPFVPEA 320
Query: 400 MLYDMENPPA-DEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYA 458
M P A ++YFG C +C + + G+ C A+D ++H CF C C LR + FY+
Sbjct: 321 ARARMREPEAREDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYS 380
Query: 459 VEKKAYCEPCYI-----NTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIP 513
V YCE Y+ E+C VC I+E+IL+A GK+YHP CF C++C++ LDGIP
Sbjct: 381 VNGSVYCEEDYLFSGFQEAAEKCCVCGHLILEKILQAMGKSYHPGCFRCIVCNKCLDGIP 440
Query: 514 FTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCG 573
FTVD ++C+ D+HK +AP+C+ C +PI+P+ G E+ VR++++DRD+H CY CEDC
Sbjct: 441 FTVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCR 500
Query: 574 GLLSEGDNQGCYPLDGHILCKTCNSARI 601
LS+ + C+PLDGH+LC C+ R+
Sbjct: 501 MQLSDEEGCCCFPLDGHLLCHGCHMQRL 528
>gi|66932982 filamin-binding LIM protein-1 isoform a [Homo sapiens]
Length = 373
Score = 196 bits (497), Expect = 7e-50
Identities = 96/242 (39%), Positives = 135/242 (55%), Gaps = 13/242 (5%)
Query: 360 VSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPADEYFGRCARC 419
+S P PP P G S Q GP P E + K D+ CA C
Sbjct: 138 LSPPPPPPQAPAEGPSVQPGPLRPMEEELPPPPAEPVEKGASTDI-----------CAFC 186
Query: 420 GENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVC 479
+ V AM + +H CFTC C +L GQ FY + + CEPCY +TLE+C C
Sbjct: 187 HKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCYQDTLERCGKC 246
Query: 480 SKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVC 539
+ + + I+RA G+A+HP CFTCV C R + F + + ++C++DF++KFAP CS+C
Sbjct: 247 GEVVRDHIIRALGQAFHPSCFTCVTCARCIGDESFALGSQNEVYCLDDFYRKFAPVCSIC 306
Query: 540 KEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLS-EGDNQGCYPLDGHILCKTCNS 598
+ PI+P G ++ +I + R+FH +CYRCEDC LLS E +QGCYPL+ H+ CK C+
Sbjct: 307 ENPIIPRDG-KDAFKIECMGRNFHENCYRCEDCRILLSVEPTDQGCYPLNNHLFCKPCHV 365
Query: 599 AR 600
R
Sbjct: 366 KR 367
Score = 36.2 bits (82), Expect = 0.091
Identities = 30/92 (32%), Positives = 37/92 (40%), Gaps = 17/92 (18%)
Query: 69 PPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSIL 128
PPPPP LD LP + PPPPP P EE +A S++
Sbjct: 86 PPPPPVLDGEDVLPDLDLLPPPPPP----------PPVLLPSEE-----EAPAPMGASLI 130
Query: 129 ADLE--CSSPYKPRPPQSSTGSTASPPVSTPV 158
ADLE SP P P + G + P P+
Sbjct: 131 ADLEQLHLSPPPPPPQAPAEGPSVQPGPLRPM 162
>gi|66932988 filamin-binding LIM protein-1 isoform c [Homo sapiens]
Length = 276
Score = 188 bits (478), Expect = 1e-47
Identities = 82/186 (44%), Positives = 118/186 (63%), Gaps = 2/186 (1%)
Query: 416 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQ 475
CA C + V AM + +H CFTC C +L GQ FY + + CEPCY +TLE+
Sbjct: 86 CAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCYQDTLER 145
Query: 476 CNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPR 535
C C + + + I+RA G+A+HP CFTCV C R + F + + ++C++DF++KFAP
Sbjct: 146 CGKCGEVVRDHIIRALGQAFHPSCFTCVTCARCIGDESFALGSQNEVYCLDDFYRKFAPV 205
Query: 536 CSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLS-EGDNQGCYPLDGHILCK 594
CS+C+ PI+P G ++ +I + R+FH +CYRCEDC LLS E +QGCYPL+ H+ CK
Sbjct: 206 CSICENPIIPRDG-KDAFKIECMGRNFHENCYRCEDCRILLSVEPTDQGCYPLNNHLFCK 264
Query: 595 TCNSAR 600
C+ R
Sbjct: 265 PCHVKR 270
>gi|37675280 ajuba isoform 2 [Homo sapiens]
Length = 121
Score = 148 bits (373), Expect = 2e-35
Identities = 55/110 (50%), Positives = 82/110 (74%)
Query: 492 GKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEE 551
GK+YHP CF C++C++ LDGIPFTVD ++C+ D+HK +AP+C+ C +PI+P+ G E+
Sbjct: 2 GKSYHPGCFRCIVCNKCLDGIPFTVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCED 61
Query: 552 TVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARI 601
VR++++DRD+H CY CEDC LS+ + C+PLDGH+LC C+ R+
Sbjct: 62 IVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHGCHMQRL 111
Score = 47.8 bits (112), Expect = 3e-05
Identities = 29/86 (33%), Positives = 40/86 (46%), Gaps = 9/86 (10%)
Query: 433 MDQVFHVDCFTCIICNNKLRGQPFYA-VEKKAYCEPCY-INTLEQCNVCSKPIM-----E 485
M + +H CF CI+CN L G PF + YC Y N +C C +PI+ E
Sbjct: 1 MGKSYHPGCFRCIVCNKCLDGIPFTVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCE 60
Query: 486 RILR--ATGKAYHPHCFTCVMCHRSL 509
I+R + + YH C+ C C L
Sbjct: 61 DIVRVISMDRDYHFECYHCEDCRMQL 86
Score = 32.3 bits (72), Expect = 1.3
Identities = 18/71 (25%), Positives = 33/71 (46%), Gaps = 10/71 (14%)
Query: 412 YFGRCARCGENVVGEGTGCT------AMDQVFHVDCFTCIICNNKL---RGQPFYAVEKK 462
Y +CA CG+ ++ GC +MD+ +H +C+ C C +L G + ++
Sbjct: 42 YAPKCAACGQPIL-PSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGH 100
Query: 463 AYCEPCYINTL 473
C C++ L
Sbjct: 101 LLCHGCHMQRL 111
>gi|66932986 filamin-binding LIM protein-1 isoform b [Homo sapiens]
Length = 374
Score = 117 bits (294), Expect = 2e-26
Identities = 59/171 (34%), Positives = 85/171 (49%), Gaps = 11/171 (6%)
Query: 360 VSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPADEYFGRCARC 419
+S P PP P G S Q GP P E + K D+ CA C
Sbjct: 138 LSPPPPPPQAPAEGPSVQPGPLRPMEEELPPPPAEPVEKGASTDI-----------CAFC 186
Query: 420 GENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVC 479
+ V AM + +H CFTC C +L GQ FY + + CEPCY +TLE+C C
Sbjct: 187 HKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCYQDTLERCGKC 246
Query: 480 SKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHK 530
+ + + I+RA G+A+HP CFTCV C R + F + + ++C++DF++
Sbjct: 247 GEVVRDHIIRALGQAFHPSCFTCVTCARCIGDESFALGSQNEVYCLDDFYR 297
Score = 47.4 bits (111), Expect = 4e-05
Identities = 37/124 (29%), Positives = 47/124 (37%), Gaps = 24/124 (19%)
Query: 476 CNVCSKPIMERIL--RATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFA 533
C C K + R L A + YH CFTC C R L G F + K
Sbjct: 183 CAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSF-------------YQKDGR 229
Query: 534 PRCSVCKEPIMPAPGQ-EETVR---IVALDRDFHVHCYRCEDCGGLLSE-----GDNQGC 584
P C C + + G+ E VR I AL + FH C+ C C + + G
Sbjct: 230 PLCEPCYQDTLERCGKCGEVVRDHIIRALGQAFHPSCFTCVTCARCIGDESFALGSQNEV 289
Query: 585 YPLD 588
Y LD
Sbjct: 290 YCLD 293
Score = 36.2 bits (82), Expect = 0.091
Identities = 30/92 (32%), Positives = 37/92 (40%), Gaps = 17/92 (18%)
Query: 69 PPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSIL 128
PPPPP LD LP + PPPPP P EE +A S++
Sbjct: 86 PPPPPVLDGEDVLPDLDLLPPPPPP----------PPVLLPSEE-----EAPAPMGASLI 130
Query: 129 ADLE--CSSPYKPRPPQSSTGSTASPPVSTPV 158
ADLE SP P P + G + P P+
Sbjct: 131 ADLEQLHLSPPPPPPQAPAEGPSVQPGPLRPM 162
Score = 36.2 bits (82), Expect = 0.091
Identities = 17/61 (27%), Positives = 27/61 (44%), Gaps = 8/61 (13%)
Query: 536 CSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKT 595
C+ C + + P + + A+ R +H C+ C C L+ Q Y DG LC+
Sbjct: 183 CAFCHKTVSP-----RELAVEAMKRQYHAQCFTCRTCRRQLA---GQSFYQKDGRPLCEP 234
Query: 596 C 596
C
Sbjct: 235 C 235
>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
Length = 727
Score = 108 bits (269), Expect = 2e-23
Identities = 107/418 (25%), Positives = 151/418 (36%), Gaps = 65/418 (15%)
Query: 136 PYKPRPPQSSTGSTASPPVSTPVT----GHKRMVIPNQPPLTATKKSTLKPQPAPQAGPI 191
P +PP +++ S ASPP++T P P + + PA A
Sbjct: 318 PASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADSPRPQASSYSPAVAASSA 377
Query: 192 PVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGY 251
P + P P + S RP+ QP P +PS G Y P Y
Sbjct: 378 PATHTSYSEGPAAPAPKPRVVTTASIRPSVY------QPVPASTYSPSPGANYSPTP--Y 429
Query: 252 NTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGY----YAAGPGY 307
P P P P+ Y P P P P Y P+ Y Y+ GP
Sbjct: 430 TPSPAPAYTPSPAPA------YTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGGPAE 483
Query: 308 GGRND---SDPTYGQQGHPNTWKRE----------PGYTPPGAGNQNPPGMYPVTGPKKT 354
+D ++ Q+ P P YTP AG Q PP G +
Sbjct: 484 PASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTP--AGPQVPP---LARGTVQR 538
Query: 355 YITDPVSAPCAPPLQPKGGHSGQL--GPSSVAP--SFRPEDELEHLTKKMLYDM------ 404
P S+ P GH + GP VA S+ PE+ K L D+
Sbjct: 539 AERFPASSRT-----PLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQ 593
Query: 405 -----ENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAV 459
E + CA+C ++GE A+ Q +H CF C C F+
Sbjct: 594 NNVYCERCYEQFFAPLCAKCNTKIMGEVMH--ALRQTWHTTCFVCAACKKPFGNSLFHME 651
Query: 460 EKKAYCEPCYINTLE-QCNVCSKPIM--ERILRATGKAYHPHCFTCVMCHRSLDGIPF 514
+ + YCE YIN +C+ C P+ ++ + A G +H CF C +CH +L+G PF
Sbjct: 652 DGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPF 709
Score = 79.0 bits (193), Expect = 1e-14
Identities = 116/487 (23%), Positives = 162/487 (33%), Gaps = 98/487 (20%)
Query: 93 PLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASP 152
P+ + K Q P + E R S + + S ILA + + + P + + +++P
Sbjct: 244 PVYQAVIKSQNKPEDEADEWARRSSNLQSRSFR-ILAQMT-GTEFMQDPDEEALRRSSTP 301
Query: 153 ----PVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPA 208
PV T + QPP A+ S P A A +A T P P
Sbjct: 302 IEHAPVCTSQATTPLLPASAQPPAAASP-SAASPPLATAAAHTAIASASTTAPASSP--- 357
Query: 209 SYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTR 268
+ S RP Q S P+ +AP++ Y GP +P V+ PS
Sbjct: 358 -----ADSPRP----QASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSV- 407
Query: 269 GGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPN-TWK 327
Y +P P PG Y+P Y P P Y P T
Sbjct: 408 ----YQPVPASTYSPSPGANYSPTP-------YTPSPAPAYTPSPAPAYTPSPVPTYTPS 456
Query: 328 REPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSF 387
P YTP A N NP P Y P PP + S + F
Sbjct: 457 PAPAYTPSPAPNYNP-------APSVAYSGGPAEPASRPPW---------VTDDSFSQKF 500
Query: 388 RPEDELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFT--CI 445
P ++K+ L PA G V G + F T C
Sbjct: 501 APGKSTTSISKQTL--PRGGPA------YTPAGPQVPPLARGTVQRAERFPASSRTPLCG 552
Query: 446 ICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMC 505
CNN +RG PF L A G+++HP FTC C
Sbjct: 553 HCNNVIRG-PF-------------------------------LVAMGRSWHPEEFTCAYC 580
Query: 506 HRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVH 565
SL + F V+ ++C + + FAP C+ C IM + AL + +H
Sbjct: 581 KTSLADVCF-VEEQNNVYCERCYEQFFAPLCAKCNTKIMGEV-------MHALRQTWHTT 632
Query: 566 CYRCEDC 572
C+ C C
Sbjct: 633 CFVCAAC 639
Score = 38.9 bits (89), Expect = 0.014
Identities = 16/52 (30%), Positives = 25/52 (48%)
Query: 415 RCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCE 466
+C C V A+ +H CF C +C+ L GQPFY+ + + C+
Sbjct: 668 KCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 719
Score = 38.5 bits (88), Expect = 0.018
Identities = 36/115 (31%), Positives = 53/115 (46%), Gaps = 18/115 (15%)
Query: 148 STASPPVSTPVTGHKRMVIPNQP-PLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPV 206
ST +PPV TP+ VIP+Q P T S + P P+P+A P P GT + +P
Sbjct: 90 STTAPPVQTPLP-----VIPHQKDPALDTNGSLVAPSPSPEARASPGTP-GTPELRPTFS 143
Query: 207 PA--------SYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSG-PQGYN 252
PA S AS P +++ K++ + P + + GS P+ YN
Sbjct: 144 PAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDLLGPKA--LPGSSQPRQYN 196
>gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]
Length = 617
Score = 98.6 bits (244), Expect = 1e-20
Identities = 104/406 (25%), Positives = 148/406 (36%), Gaps = 59/406 (14%)
Query: 143 QSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQ 202
+SS + S + +TG + M P++ L ++ PA A P +
Sbjct: 219 RSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSRPQASSYSPAVAASSAPATHTSYSEGP 278
Query: 203 PQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQ------GYNTQPV 256
P P + S RP+ QP P +PS G Y P Y P
Sbjct: 279 AAPAPKPRVVTTASIRPSVY------QPVPASTYSPSPGANYSPTPYTPSPAPAYTPSPA 332
Query: 257 PVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPT 316
P P P+ Y P P P P Y P Y G A P +D +
Sbjct: 333 PAYTPSPVPT------YTPSPAPAYTPSPAPNYNPAPSVAYSG-GPAEPASRPPWVTDDS 385
Query: 317 YGQQGHPNTW----------KREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAP 366
+ Q+ P + P YTP AG Q PP G + P S+
Sbjct: 386 FSQKFAPGKSTTSISKQTLPRGGPAYTP--AGPQVPP---LARGTVQRAERFPASS---- 436
Query: 367 PLQPKGGHSGQL--GPSSVA--PSFRPEDELEHLTKKMLYDM-----------ENPPADE 411
P GH + GP VA S+ PE+ K L D+ E
Sbjct: 437 -RTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQF 495
Query: 412 YFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYIN 471
+ CA+C ++GE A+ Q +H CF C C F+ + + YCE YIN
Sbjct: 496 FAPLCAKCNTKIMGE--VMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYIN 553
Query: 472 TLE-QCNVCSKPIM--ERILRATGKAYHPHCFTCVMCHRSLDGIPF 514
+C+ C P+ ++ + A G +H CF C +CH +L+G PF
Sbjct: 554 LFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPF 599
Score = 67.4 bits (163), Expect = 4e-11
Identities = 88/359 (24%), Positives = 117/359 (32%), Gaps = 83/359 (23%)
Query: 217 SRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYI 276
SRP Q S P+ +AP++ Y GP +P V+ PS Y +
Sbjct: 251 SRP----QASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSV-----YQPV 301
Query: 277 PPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPN-TWKREPGYTPP 335
P P PG Y+P Y P P Y P T P YTP
Sbjct: 302 PASTYSPSPGANYSPTP-------YTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPS 354
Query: 336 GAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEH 395
A N NP P Y P PP + S + F P
Sbjct: 355 PAPNYNP-------APSVAYSGGPAEPASRPPW---------VTDDSFSQKFAPGKSTTS 398
Query: 396 LTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFT--CIICNNKLRG 453
++K+ L PA G V G + F T C CNN +RG
Sbjct: 399 ISKQTL--PRGGPA------YTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRG 450
Query: 454 QPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIP 513
PF L A G+++HP FTC C SL +
Sbjct: 451 -PF-------------------------------LVAMGRSWHPEEFTCAYCKTSLADVC 478
Query: 514 FTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC 572
F V+ ++C + + FAP C+ C IM + AL + +H C+ C C
Sbjct: 479 F-VEEQNNVYCERCYEQFFAPLCAKCNTKIMGEV-------MHALRQTWHTTCFVCAAC 529
Score = 38.9 bits (89), Expect = 0.014
Identities = 16/52 (30%), Positives = 25/52 (48%)
Query: 415 RCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCE 466
+C C V A+ +H CF C +C+ L GQPFY+ + + C+
Sbjct: 558 KCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 609
>gi|54112385 four and a half LIM domains 3 [Homo sapiens]
Length = 280
Score = 94.4 bits (233), Expect = 3e-19
Identities = 57/189 (30%), Positives = 83/189 (43%), Gaps = 8/189 (4%)
Query: 412 YFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYIN 471
+ +C+ CGE V+ Q +H CF C C L + F + YC PCY N
Sbjct: 97 FSSQCSACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYEN 156
Query: 472 TL-EQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHK 530
+C CSK + + + + +H C C C L G FT +C+ F +
Sbjct: 157 KFAPRCARCSKTLTQGGVTYRDQPWHRECLVCTGCQTPLAGQQFT-SRDEDPYCVACFGE 215
Query: 531 KFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGH 590
FAP+CS CK PI+ G + + DR +H +C+ C C L QG P
Sbjct: 216 LFAPKCSSCKRPIVGLGGGK---YVSFEDRHWHHNCFSCARCSTSLV---GQGFVPDGDQ 269
Query: 591 ILCKTCNSA 599
+LC+ C+ A
Sbjct: 270 VLCQGCSQA 278
Score = 90.9 bits (224), Expect = 3e-18
Identities = 52/194 (26%), Positives = 80/194 (41%), Gaps = 17/194 (8%)
Query: 416 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTL-E 474
CA C + + + D+ FH CF C C L +PF + + C CY +
Sbjct: 40 CAECQQLIGHDSRELFYEDRHFHEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSS 99
Query: 475 QCNVCSKPIM--ERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKF 532
QC+ C + +M R L G+ +H HCF C C + L F D G +C+ + KF
Sbjct: 100 QCSACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGA-HYCVPCYENKF 158
Query: 533 APRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLL------SEGDNQGCYP 586
APRC+ C + + + D+ +H C C C L S ++ C
Sbjct: 159 APRCARCSKTLTQG-------GVTYRDQPWHRECLVCTGCQTPLAGQQFTSRDEDPYCVA 211
Query: 587 LDGHILCKTCNSAR 600
G + C+S +
Sbjct: 212 CFGELFAPKCSSCK 225
Score = 77.8 bits (190), Expect = 3e-14
Identities = 52/176 (29%), Positives = 73/176 (41%), Gaps = 12/176 (6%)
Query: 440 DCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTL-EQCNVCSKPI--MERILRATGKAYH 496
+ F C CN L G+ + + YC PCY NT C C + I R L + +H
Sbjct: 3 ESFDCAKCNESLYGRKYIQTDSGPYCVPCYDNTFANTCAECQQLIGHDSRELFYEDRHFH 62
Query: 497 PHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIV 556
CF C C RSL PFT L+ C + + F+ +CS C E +MP + E
Sbjct: 63 EGCFRCCRCQRSLADEPFTCQDSELL-CNDCYCSAFSSQCSACGETVMPGSRKLEYG--- 118
Query: 557 ALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL 612
+ +H HC+ C C L ++ P G C C + A+ S L
Sbjct: 119 --GQTWHEHCFLCSGCEQPLG---SRSFVPDKGAHYCVPCYENKFAPRCARCSKTL 169
>gi|109638745 transforming growth factor beta 1 induced transcript 1
isoform 1 [Homo sapiens]
Length = 461
Score = 90.9 bits (224), Expect = 3e-18
Identities = 68/249 (27%), Positives = 106/249 (42%), Gaps = 26/249 (10%)
Query: 359 PVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPE-DELEHLTKKMLYDMENPPADEYFGRCA 417
P S P PP+ + + PS P+ + D + L + L P + G C
Sbjct: 175 PASGPTQPPVVSS---TNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAK--GLCG 229
Query: 418 RCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLE-QC 476
C + + G+ TA+ + +H + F C C+ L G F+ + +C CY +C
Sbjct: 230 SCNKPIAGQVV--TALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRC 287
Query: 477 NVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRC 536
C++PI +++ A G +HP F CV C F + G +C DF + FAPRC
Sbjct: 288 GFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFH-EREGRPYCRRDFLQLFAPRC 346
Query: 537 SVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEG---DNQGCYPLDGHI-- 591
C+ PI+ I AL +H C+ C +C S G +++G + H
Sbjct: 347 QGCQGPILDN-------YISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHA 399
Query: 592 ----LCKTC 596
LC TC
Sbjct: 400 RRGSLCATC 408
Score = 54.3 bits (129), Expect = 3e-07
Identities = 29/90 (32%), Positives = 40/90 (44%), Gaps = 1/90 (1%)
Query: 431 TAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCY-INTLEQCNVCSKPIMERILR 489
+A+ ++H DCF C C G F+ E + CE + C C P+ R +
Sbjct: 359 SALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVS 418
Query: 490 ATGKAYHPHCFTCVMCHRSLDGIPFTVDAG 519
A G+ +HP FTC C R L F AG
Sbjct: 419 ALGRRFHPDHFTCTFCLRPLTKGSFQERAG 448
Score = 42.4 bits (98), Expect = 0.001
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 416 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYI 470
CA CG V G +A+ + FH D FTC C L F K YC+PC++
Sbjct: 405 CATCGLPVTGRCV--SALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFL 457
>gi|21361591 transforming growth factor beta 1 induced transcript 1
isoform 2 [Homo sapiens]
Length = 444
Score = 90.9 bits (224), Expect = 3e-18
Identities = 68/249 (27%), Positives = 106/249 (42%), Gaps = 26/249 (10%)
Query: 359 PVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPE-DELEHLTKKMLYDMENPPADEYFGRCA 417
P S P PP+ + + PS P+ + D + L + L P + G C
Sbjct: 158 PASGPTQPPVVSS---TNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAK--GLCG 212
Query: 418 RCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLE-QC 476
C + + G+ TA+ + +H + F C C+ L G F+ + +C CY +C
Sbjct: 213 SCNKPIAGQVV--TALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRC 270
Query: 477 NVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRC 536
C++PI +++ A G +HP F CV C F + G +C DF + FAPRC
Sbjct: 271 GFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFH-EREGRPYCRRDFLQLFAPRC 329
Query: 537 SVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEG---DNQGCYPLDGHI-- 591
C+ PI+ I AL +H C+ C +C S G +++G + H
Sbjct: 330 QGCQGPILDN-------YISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHA 382
Query: 592 ----LCKTC 596
LC TC
Sbjct: 383 RRGSLCATC 391
Score = 54.3 bits (129), Expect = 3e-07
Identities = 29/90 (32%), Positives = 40/90 (44%), Gaps = 1/90 (1%)
Query: 431 TAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCY-INTLEQCNVCSKPIMERILR 489
+A+ ++H DCF C C G F+ E + CE + C C P+ R +
Sbjct: 342 SALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVS 401
Query: 490 ATGKAYHPHCFTCVMCHRSLDGIPFTVDAG 519
A G+ +HP FTC C R L F AG
Sbjct: 402 ALGRRFHPDHFTCTFCLRPLTKGSFQERAG 431
Score = 42.4 bits (98), Expect = 0.001
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 416 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYI 470
CA CG V G +A+ + FH D FTC C L F K YC+PC++
Sbjct: 388 CATCGLPVTGRCV--SALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFL 440
>gi|170932514 paxillin isoform 1 [Homo sapiens]
Length = 591
Score = 84.7 bits (208), Expect = 2e-16
Identities = 67/259 (25%), Positives = 109/259 (42%), Gaps = 25/259 (9%)
Query: 365 APPLQPKGGHSGQLGPSSVAPSF---RPEDELEHLTKKMLYDMEN-PPADEYFGRCARCG 420
+P Q +GG Q S +P +P +L+ + + D+ A G C C
Sbjct: 303 SPGGQDEGGFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACK 362
Query: 421 ENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLE-QCNVC 479
+ + G+ TAM + +H + F C C ++ + F+ + + YCE Y N +C C
Sbjct: 363 KPIAGQVV--TAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYC 420
Query: 480 SKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVC 539
+ PI+++++ A + +HP F C C F + G +C +D+ FAP+C C
Sbjct: 421 NGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFH-EKDGKAYCRKDYFDMFAPKCGGC 479
Query: 540 KEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC-----GGLLSEGDNQGCYPLDGH---- 590
I+ I AL+ +H C+ C +C G E D Q + H
Sbjct: 480 ARAILEN-------YISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRG 532
Query: 591 ILCKTCNSARI-RVLTAKA 608
LC C R +TA A
Sbjct: 533 SLCSGCQKPITGRCITAMA 551
Score = 56.2 bits (134), Expect = 8e-08
Identities = 47/170 (27%), Positives = 67/170 (39%), Gaps = 17/170 (10%)
Query: 343 PGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLY 402
P Y GP I D V P+ Q G F +D + +K +
Sbjct: 415 PRCYYCNGP----ILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYC-RKDYF 469
Query: 403 DMENPPADEYFGRCARCG-ENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEK 461
DM P G CAR EN + +A++ ++H +CF C C F+ +
Sbjct: 470 DMFAPKC----GGCARAILENYI------SALNTLWHPECFVCRECFTPFVNGSFFEHDG 519
Query: 462 KAYCEPCYINTLEQ-CNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLD 510
+ YCE Y C+ C KPI R + A K +HP F C C + L+
Sbjct: 520 QPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLN 569
Score = 36.2 bits (82), Expect = 0.091
Identities = 17/55 (30%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 416 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYI 470
C+ C + + G TAM + FH + F C C +L F K YC+ C++
Sbjct: 535 CSGCQKPITGRCI--TAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFL 587
Score = 30.8 bits (68), Expect = 3.8
Identities = 40/167 (23%), Positives = 60/167 (35%), Gaps = 29/167 (17%)
Query: 8 PPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPK-------------PK 54
P S G P V E H + P+ S + P + + +
Sbjct: 100 PQDSVGSPCSRVG---EEEHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQ 156
Query: 55 YNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPP-PLDEEAFKVQGNPGGKTLEER 113
+NP P E + PP P L +P + PL +E K GG+ LE+
Sbjct: 157 HNPPGFPADEANSSPPLPGALSPLYGVPETNSPLGGKAGPLTKEKPK---RNGGRGLEDV 213
Query: 114 RSSLDAEIDSLTSILADL---------ECSSPYKPRPPQSSTGSTAS 151
R S+++ +D L S + E SSP + Q T +AS
Sbjct: 214 RPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSTQQQTRISAS 260
>gi|170932518 paxillin isoform 3 [Homo sapiens]
Length = 424
Score = 84.3 bits (207), Expect = 3e-16
Identities = 64/248 (25%), Positives = 104/248 (41%), Gaps = 24/248 (9%)
Query: 373 GHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMEN-PPADEYFGRCARCGENVVGEGTGCT 431
G +G P P +P +L+ + + D+ A G C C + + G+ T
Sbjct: 149 GKTGSSSPPGGPP--KPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVV--T 204
Query: 432 AMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLE-QCNVCSKPIMERILRA 490
AM + +H + F C C ++ + F+ + + YCE Y N +C C+ PI+++++ A
Sbjct: 205 AMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTA 264
Query: 491 TGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQE 550
+ +HP F C C F + G +C +D+ FAP+C C I+
Sbjct: 265 LDRTWHPEHFFCAQCGAFFGPEGFH-EKDGKAYCRKDYFDMFAPKCGGCARAILEN---- 319
Query: 551 ETVRIVALDRDFHVHCYRCEDC-----GGLLSEGDNQGCYPLDGH----ILCKTCNSARI 601
I AL+ +H C+ C +C G E D Q + H LC C
Sbjct: 320 ---YISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPIT 376
Query: 602 -RVLTAKA 608
R +TA A
Sbjct: 377 GRCITAMA 384
Score = 56.2 bits (134), Expect = 8e-08
Identities = 47/170 (27%), Positives = 67/170 (39%), Gaps = 17/170 (10%)
Query: 343 PGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLY 402
P Y GP I D V P+ Q G F +D + +K +
Sbjct: 248 PRCYYCNGP----ILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYC-RKDYF 302
Query: 403 DMENPPADEYFGRCARCG-ENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEK 461
DM P G CAR EN + +A++ ++H +CF C C F+ +
Sbjct: 303 DMFAPKC----GGCARAILENYI------SALNTLWHPECFVCRECFTPFVNGSFFEHDG 352
Query: 462 KAYCEPCYINTLEQ-CNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLD 510
+ YCE Y C+ C KPI R + A K +HP F C C + L+
Sbjct: 353 QPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLN 402
Score = 36.2 bits (82), Expect = 0.091
Identities = 17/55 (30%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 416 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYI 470
C+ C + + G TAM + FH + F C C +L F K YC+ C++
Sbjct: 368 CSGCQKPITGRCI--TAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFL 420
Score = 30.4 bits (67), Expect = 5.0
Identities = 30/108 (27%), Positives = 45/108 (41%), Gaps = 13/108 (12%)
Query: 54 KYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPP-PLDEEAFKVQGNPGGKTLEE 112
++NP P E + PP P L +P + PL +E K GG+ LE+
Sbjct: 23 QHNPPGFPADEANSSPPLPGALSPLYGVPETNSPLGGKAGPLTKEKPK---RNGGRGLED 79
Query: 113 RRSSLDAEIDSLTSILADL---------ECSSPYKPRPPQSSTGSTAS 151
R S+++ +D L S + E SSP + Q T +AS
Sbjct: 80 VRPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSTQQQTRISAS 127
>gi|170932516 paxillin isoform 2 [Homo sapiens]
Length = 557
Score = 84.3 bits (207), Expect = 3e-16
Identities = 64/248 (25%), Positives = 104/248 (41%), Gaps = 24/248 (9%)
Query: 373 GHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMEN-PPADEYFGRCARCGENVVGEGTGCT 431
G +G P P +P +L+ + + D+ A G C C + + G+ T
Sbjct: 282 GKTGSSSPPGGPP--KPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVV--T 337
Query: 432 AMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLE-QCNVCSKPIMERILRA 490
AM + +H + F C C ++ + F+ + + YCE Y N +C C+ PI+++++ A
Sbjct: 338 AMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTA 397
Query: 491 TGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQE 550
+ +HP F C C F + G +C +D+ FAP+C C I+
Sbjct: 398 LDRTWHPEHFFCAQCGAFFGPEGFH-EKDGKAYCRKDYFDMFAPKCGGCARAILEN---- 452
Query: 551 ETVRIVALDRDFHVHCYRCEDC-----GGLLSEGDNQGCYPLDGH----ILCKTCNSARI 601
I AL+ +H C+ C +C G E D Q + H LC C
Sbjct: 453 ---YISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPIT 509
Query: 602 -RVLTAKA 608
R +TA A
Sbjct: 510 GRCITAMA 517
Score = 56.2 bits (134), Expect = 8e-08
Identities = 47/170 (27%), Positives = 67/170 (39%), Gaps = 17/170 (10%)
Query: 343 PGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLY 402
P Y GP I D V P+ Q G F +D + +K +
Sbjct: 381 PRCYYCNGP----ILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYC-RKDYF 435
Query: 403 DMENPPADEYFGRCARCG-ENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEK 461
DM P G CAR EN + +A++ ++H +CF C C F+ +
Sbjct: 436 DMFAPKC----GGCARAILENYI------SALNTLWHPECFVCRECFTPFVNGSFFEHDG 485
Query: 462 KAYCEPCYINTLEQ-CNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLD 510
+ YCE Y C+ C KPI R + A K +HP F C C + L+
Sbjct: 486 QPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLN 535
Score = 36.2 bits (82), Expect = 0.091
Identities = 17/55 (30%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Query: 416 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYI 470
C+ C + + G TAM + FH + F C C +L F K YC+ C++
Sbjct: 501 CSGCQKPITGRCI--TAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFL 553
Score = 30.8 bits (68), Expect = 3.8
Identities = 40/167 (23%), Positives = 60/167 (35%), Gaps = 29/167 (17%)
Query: 8 PPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPK-------------PK 54
P S G P V E H + P+ S + P + + +
Sbjct: 100 PQDSVGSPCSRVG---EEEHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQ 156
Query: 55 YNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPP-PLDEEAFKVQGNPGGKTLEER 113
+NP P E + PP P L +P + PL +E K GG+ LE+
Sbjct: 157 HNPPGFPADEANSSPPLPGALSPLYGVPETNSPLGGKAGPLTKEKPK---RNGGRGLEDV 213
Query: 114 RSSLDAEIDSLTSILADL---------ECSSPYKPRPPQSSTGSTAS 151
R S+++ +D L S + E SSP + Q T +AS
Sbjct: 214 RPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSTQQQTRISAS 260
>gi|221316659 leupaxin isoform 1 [Homo sapiens]
Length = 391
Score = 84.0 bits (206), Expect = 4e-16
Identities = 50/182 (27%), Positives = 80/182 (43%), Gaps = 14/182 (7%)
Query: 414 GRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTL 473
G CA C + + G+ A+ Q +H + F C C ++ PF+ AYC Y
Sbjct: 155 GHCASCQKPIAGKVIH--ALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLF 212
Query: 474 E-QCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKF 532
+C C+ PI++++L A + +HP F C C F + +C +DF F
Sbjct: 213 SPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFH-EKDKKPYCRKDFLAMF 271
Query: 533 APRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHIL 592
+P+C C P++ + A+D +H C+ C DC S G + LDG
Sbjct: 272 SPKCGGCNRPVLEN-------YLSAMDTVWHPECFVCGDCFTSFSTG---SFFELDGRPF 321
Query: 593 CK 594
C+
Sbjct: 322 CE 323
Score = 74.3 bits (181), Expect = 3e-13
Identities = 51/168 (30%), Positives = 75/168 (44%), Gaps = 15/168 (8%)
Query: 415 RCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLE 474
RCA C ++ + TAM+Q +H + F C C + F+ +KK YC ++
Sbjct: 215 RCAYCAAPILDKVL--TAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFS 272
Query: 475 -QCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLD-GIPFTVDAGGLIHCIEDFHKKF 532
+C C++P++E L A +HP CF C C S G F +D G C +H +
Sbjct: 273 PKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELD--GRPFCELHYHHRR 330
Query: 533 APRCSVCKEPIMPAPGQEETVR-IVALDRDFHVHCYRCEDCGGLLSEG 579
C C +PI T R I A+ FH + C C LS+G
Sbjct: 331 GTLCHGCGQPI--------TGRCISAMGYKFHPEHFVCAFCLTQLSKG 370
Score = 38.5 bits (88), Expect = 0.018
Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 2/54 (3%)
Query: 416 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCY 469
C CG+ + G +AM FH + F C C +L F K YC+PC+
Sbjct: 334 CHGCGQPITGRCI--SAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCF 385
>gi|4758670 leupaxin isoform 2 [Homo sapiens]
Length = 386
Score = 84.0 bits (206), Expect = 4e-16
Identities = 50/182 (27%), Positives = 80/182 (43%), Gaps = 14/182 (7%)
Query: 414 GRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTL 473
G CA C + + G+ A+ Q +H + F C C ++ PF+ AYC Y
Sbjct: 150 GHCASCQKPIAGKVIH--ALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLF 207
Query: 474 E-QCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKF 532
+C C+ PI++++L A + +HP F C C F + +C +DF F
Sbjct: 208 SPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFH-EKDKKPYCRKDFLAMF 266
Query: 533 APRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHIL 592
+P+C C P++ + A+D +H C+ C DC S G + LDG
Sbjct: 267 SPKCGGCNRPVLEN-------YLSAMDTVWHPECFVCGDCFTSFSTG---SFFELDGRPF 316
Query: 593 CK 594
C+
Sbjct: 317 CE 318
Score = 74.3 bits (181), Expect = 3e-13
Identities = 51/168 (30%), Positives = 75/168 (44%), Gaps = 15/168 (8%)
Query: 415 RCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLE 474
RCA C ++ + TAM+Q +H + F C C + F+ +KK YC ++
Sbjct: 210 RCAYCAAPILDKVL--TAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFS 267
Query: 475 -QCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLD-GIPFTVDAGGLIHCIEDFHKKF 532
+C C++P++E L A +HP CF C C S G F +D G C +H +
Sbjct: 268 PKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELD--GRPFCELHYHHRR 325
Query: 533 APRCSVCKEPIMPAPGQEETVR-IVALDRDFHVHCYRCEDCGGLLSEG 579
C C +PI T R I A+ FH + C C LS+G
Sbjct: 326 GTLCHGCGQPI--------TGRCISAMGYKFHPEHFVCAFCLTQLSKG 365
Score = 38.5 bits (88), Expect = 0.018
Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 2/54 (3%)
Query: 416 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCY 469
C CG+ + G +AM FH + F C C +L F K YC+PC+
Sbjct: 329 CHGCGQPITGRCI--SAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCF 380
>gi|87159836 four and a half LIM domains 2 [Homo sapiens]
Length = 279
Score = 83.6 bits (205), Expect = 5e-16
Identities = 52/195 (26%), Positives = 79/195 (40%), Gaps = 20/195 (10%)
Query: 409 ADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPC 468
++EY +C C + ++ +H CF C C + + F + + +C PC
Sbjct: 94 SNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPC 153
Query: 469 YINT-LEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIED 527
Y QC C KPI + + +H CF C C + L G FT +C+
Sbjct: 154 YEKQHAMQCVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTA-RDDFAYCLNC 212
Query: 528 FHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCG------GLLSEGDN 581
F +A +C+ C PI G T I +R +H C+ C+ C G L+E D+
Sbjct: 213 FCDLYAKKCAGCTNPISGLGG---TKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD 269
Query: 582 QGCYPLDGHILCKTC 596
ILC C
Sbjct: 270 ---------ILCPDC 275
Score = 78.6 bits (192), Expect = 2e-14
Identities = 47/165 (28%), Positives = 72/165 (43%), Gaps = 11/165 (6%)
Query: 416 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTL-E 474
C CG+ + + + D+ +H CF C C N L +PF A E + C CY N
Sbjct: 40 CEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSS 99
Query: 475 QCNVCSKPIM--ERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKF 532
+C C K IM R + G ++H CF C C + + G + C+ + K+
Sbjct: 100 KCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPI-GTKSFIPKDNQNFCVPCYEKQH 158
Query: 533 APRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLS 577
A +C CK+PI T + ++ +H C+ C C LS
Sbjct: 159 AMQCVQCKKPI-------TTGGVTYREQPWHKECFVCTACRKQLS 196
Score = 63.9 bits (154), Expect = 4e-10
Identities = 44/159 (27%), Positives = 65/159 (40%), Gaps = 14/159 (8%)
Query: 442 FTCIICNNKLRGQPFYAVEKKAYCEPCYINTL--EQCNVCSKPI--MERILRATGKAYHP 497
F C CN L G+ + E+ YC C+ TL C C KPI + L + +H
Sbjct: 5 FDCHHCNESLFGKKYILREESPYCVVCF-ETLFANTCEECGKPIGCDCKDLSYKDRHWHE 63
Query: 498 HCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVA 557
CF C C SL PF L+ C + + +++ +C CK+ IMP T ++
Sbjct: 64 ACFHCSQCRNSLVDKPFAAKEDQLL-CTDCYSNEYSSKCQECKKTIMPG-----TRKMEY 117
Query: 558 LDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTC 596
+H C+ C C + + P D C C
Sbjct: 118 KGSSWHETCFICHRCQQPIG---TKSFIPKDNQNFCVPC 153
>gi|87159834 four and a half LIM domains 2 [Homo sapiens]
Length = 279
Score = 83.6 bits (205), Expect = 5e-16
Identities = 52/195 (26%), Positives = 79/195 (40%), Gaps = 20/195 (10%)
Query: 409 ADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPC 468
++EY +C C + ++ +H CF C C + + F + + +C PC
Sbjct: 94 SNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPC 153
Query: 469 YINT-LEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIED 527
Y QC C KPI + + +H CF C C + L G FT +C+
Sbjct: 154 YEKQHAMQCVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTA-RDDFAYCLNC 212
Query: 528 FHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCG------GLLSEGDN 581
F +A +C+ C PI G T I +R +H C+ C+ C G L+E D+
Sbjct: 213 FCDLYAKKCAGCTNPISGLGG---TKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD 269
Query: 582 QGCYPLDGHILCKTC 596
ILC C
Sbjct: 270 ---------ILCPDC 275
Score = 78.6 bits (192), Expect = 2e-14
Identities = 47/165 (28%), Positives = 72/165 (43%), Gaps = 11/165 (6%)
Query: 416 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTL-E 474
C CG+ + + + D+ +H CF C C N L +PF A E + C CY N
Sbjct: 40 CEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSS 99
Query: 475 QCNVCSKPIM--ERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKF 532
+C C K IM R + G ++H CF C C + + G + C+ + K+
Sbjct: 100 KCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPI-GTKSFIPKDNQNFCVPCYEKQH 158
Query: 533 APRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLS 577
A +C CK+PI T + ++ +H C+ C C LS
Sbjct: 159 AMQCVQCKKPI-------TTGGVTYREQPWHKECFVCTACRKQLS 196
Score = 63.9 bits (154), Expect = 4e-10
Identities = 44/159 (27%), Positives = 65/159 (40%), Gaps = 14/159 (8%)
Query: 442 FTCIICNNKLRGQPFYAVEKKAYCEPCYINTL--EQCNVCSKPI--MERILRATGKAYHP 497
F C CN L G+ + E+ YC C+ TL C C KPI + L + +H
Sbjct: 5 FDCHHCNESLFGKKYILREESPYCVVCF-ETLFANTCEECGKPIGCDCKDLSYKDRHWHE 63
Query: 498 HCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVA 557
CF C C SL PF L+ C + + +++ +C CK+ IMP T ++
Sbjct: 64 ACFHCSQCRNSLVDKPFAAKEDQLL-CTDCYSNEYSSKCQECKKTIMPG-----TRKMEY 117
Query: 558 LDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTC 596
+H C+ C C + + P D C C
Sbjct: 118 KGSSWHETCFICHRCQQPIG---TKSFIPKDNQNFCVPC 153
>gi|42403575 four and a half LIM domains 2 [Homo sapiens]
Length = 279
Score = 83.6 bits (205), Expect = 5e-16
Identities = 52/195 (26%), Positives = 79/195 (40%), Gaps = 20/195 (10%)
Query: 409 ADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPC 468
++EY +C C + ++ +H CF C C + + F + + +C PC
Sbjct: 94 SNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPC 153
Query: 469 YINT-LEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIED 527
Y QC C KPI + + +H CF C C + L G FT +C+
Sbjct: 154 YEKQHAMQCVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTA-RDDFAYCLNC 212
Query: 528 FHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCG------GLLSEGDN 581
F +A +C+ C PI G T I +R +H C+ C+ C G L+E D+
Sbjct: 213 FCDLYAKKCAGCTNPISGLGG---TKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD 269
Query: 582 QGCYPLDGHILCKTC 596
ILC C
Sbjct: 270 ---------ILCPDC 275
Score = 78.6 bits (192), Expect = 2e-14
Identities = 47/165 (28%), Positives = 72/165 (43%), Gaps = 11/165 (6%)
Query: 416 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTL-E 474
C CG+ + + + D+ +H CF C C N L +PF A E + C CY N
Sbjct: 40 CEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSS 99
Query: 475 QCNVCSKPIM--ERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKF 532
+C C K IM R + G ++H CF C C + + G + C+ + K+
Sbjct: 100 KCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPI-GTKSFIPKDNQNFCVPCYEKQH 158
Query: 533 APRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLS 577
A +C CK+PI T + ++ +H C+ C C LS
Sbjct: 159 AMQCVQCKKPI-------TTGGVTYREQPWHKECFVCTACRKQLS 196
Score = 63.9 bits (154), Expect = 4e-10
Identities = 44/159 (27%), Positives = 65/159 (40%), Gaps = 14/159 (8%)
Query: 442 FTCIICNNKLRGQPFYAVEKKAYCEPCYINTL--EQCNVCSKPI--MERILRATGKAYHP 497
F C CN L G+ + E+ YC C+ TL C C KPI + L + +H
Sbjct: 5 FDCHHCNESLFGKKYILREESPYCVVCF-ETLFANTCEECGKPIGCDCKDLSYKDRHWHE 63
Query: 498 HCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVA 557
CF C C SL PF L+ C + + +++ +C CK+ IMP T ++
Sbjct: 64 ACFHCSQCRNSLVDKPFAAKEDQLL-CTDCYSNEYSSKCQECKKTIMPG-----TRKMEY 117
Query: 558 LDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTC 596
+H C+ C C + + P D C C
Sbjct: 118 KGSSWHETCFICHRCQQPIG---TKSFIPKDNQNFCVPC 153
>gi|87159832 four and a half LIM domains 2 [Homo sapiens]
Length = 279
Score = 83.6 bits (205), Expect = 5e-16
Identities = 52/195 (26%), Positives = 79/195 (40%), Gaps = 20/195 (10%)
Query: 409 ADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPC 468
++EY +C C + ++ +H CF C C + + F + + +C PC
Sbjct: 94 SNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPC 153
Query: 469 YINT-LEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIED 527
Y QC C KPI + + +H CF C C + L G FT +C+
Sbjct: 154 YEKQHAMQCVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTA-RDDFAYCLNC 212
Query: 528 FHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCG------GLLSEGDN 581
F +A +C+ C PI G T I +R +H C+ C+ C G L+E D+
Sbjct: 213 FCDLYAKKCAGCTNPISGLGG---TKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD 269
Query: 582 QGCYPLDGHILCKTC 596
ILC C
Sbjct: 270 ---------ILCPDC 275
Score = 78.6 bits (192), Expect = 2e-14
Identities = 47/165 (28%), Positives = 72/165 (43%), Gaps = 11/165 (6%)
Query: 416 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTL-E 474
C CG+ + + + D+ +H CF C C N L +PF A E + C CY N
Sbjct: 40 CEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSS 99
Query: 475 QCNVCSKPIM--ERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKF 532
+C C K IM R + G ++H CF C C + + G + C+ + K+
Sbjct: 100 KCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPI-GTKSFIPKDNQNFCVPCYEKQH 158
Query: 533 APRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLS 577
A +C CK+PI T + ++ +H C+ C C LS
Sbjct: 159 AMQCVQCKKPI-------TTGGVTYREQPWHKECFVCTACRKQLS 196
Score = 63.9 bits (154), Expect = 4e-10
Identities = 44/159 (27%), Positives = 65/159 (40%), Gaps = 14/159 (8%)
Query: 442 FTCIICNNKLRGQPFYAVEKKAYCEPCYINTL--EQCNVCSKPI--MERILRATGKAYHP 497
F C CN L G+ + E+ YC C+ TL C C KPI + L + +H
Sbjct: 5 FDCHHCNESLFGKKYILREESPYCVVCF-ETLFANTCEECGKPIGCDCKDLSYKDRHWHE 63
Query: 498 HCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVA 557
CF C C SL PF L+ C + + +++ +C CK+ IMP T ++
Sbjct: 64 ACFHCSQCRNSLVDKPFAAKEDQLL-CTDCYSNEYSSKCQECKKTIMPG-----TRKMEY 117
Query: 558 LDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTC 596
+H C+ C C + + P D C C
Sbjct: 118 KGSSWHETCFICHRCQQPIG---TKSFIPKDNQNFCVPC 153
>gi|30410801 activator of cAMP-responsive element modulator (CREM)
in testis [Homo sapiens]
Length = 284
Score = 80.9 bits (198), Expect = 3e-15
Identities = 50/190 (26%), Positives = 76/190 (40%), Gaps = 17/190 (8%)
Query: 416 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTL-E 474
C C + + + D+ +H CF C CN+ L +PF A +++ C CY N
Sbjct: 41 CEECKKPIESDSKDLCYKDRHWHEGCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSS 100
Query: 475 QCNVCSKPIM--ERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKF 532
+C C + IM R + G +H CF C C + + P G +C+ F K+F
Sbjct: 101 KCFHCKRTIMPGSRKMEFKGNYWHETCFVCENCRQPIGTKPLISKESG-NYCVPCFEKEF 159
Query: 533 APRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC------GGLLSEGDNQGCYP 586
A C+ CK+ I I D+ +H C+ C C +S D C
Sbjct: 160 AHYCNFCKKVITSG-------GITFCDQLWHKECFLCSGCRKDLCEEQFMSRDDYPFCMD 212
Query: 587 LDGHILCKTC 596
H+ C
Sbjct: 213 CYNHLYANKC 222
Score = 73.2 bits (178), Expect = 7e-13
Identities = 45/191 (23%), Positives = 73/191 (38%), Gaps = 8/191 (4%)
Query: 409 ADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPC 468
++E +C C ++ +H CF C C + +P + E YC PC
Sbjct: 95 SNECSSKCFHCKRTIMPGSRKMEFKGNYWHETCFVCENCRQPIGTKPLISKESGNYCVPC 154
Query: 469 YINTL-EQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIED 527
+ CN C K I + + +H CF C C + L F + C++
Sbjct: 155 FEKEFAHYCNFCKKVITSGGITFCDQLWHKECFLCSGCRKDLCEEQF-MSRDDYPFCMDC 213
Query: 528 FHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPL 587
++ +A +C C +PI G + I D +H C+ C C L +G
Sbjct: 214 YNHLYANKCVACSKPISGLTGAK---FICFQDSQWHSECFNCGKCSVSLV---GKGFLTQ 267
Query: 588 DGHILCKTCNS 598
+ I C+ C S
Sbjct: 268 NKEIFCQKCGS 278
Score = 64.3 bits (155), Expect = 3e-10
Identities = 48/178 (26%), Positives = 70/178 (39%), Gaps = 16/178 (8%)
Query: 442 FTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQ-CNVCSKPIM--ERILRATGKAYHPH 498
F C C L G+ + + YC CY C C KPI + L + +H
Sbjct: 6 FYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDRHWHEG 65
Query: 499 CFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVAL 558
CF C C+ SL PF L+ C E + + + +C CK IMP + E
Sbjct: 66 CFKCTKCNHSLVEKPFAAKDERLL-CTECYSNECSSKCFHCKRTIMPGSRKME-----FK 119
Query: 559 DRDFHVHCYRCEDC------GGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKAST 610
+H C+ CE+C L+S+ C P CN + +V+T+ T
Sbjct: 120 GNYWHETCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCK-KVITSGGIT 176
>gi|7662330 actin binding LIM protein family, member 3 [Homo
sapiens]
Length = 683
Score = 80.1 bits (196), Expect = 5e-15
Identities = 57/210 (27%), Positives = 88/210 (41%), Gaps = 26/210 (12%)
Query: 406 NPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYC 465
NP +C RCG+ GE + FH+ CFTC +C L F+ ++ C
Sbjct: 13 NPRGSSNVIQCYRCGDTCKGEVV--RVHNNHFHIRCFTCQVCGCGLAQSGFFFKNQEYIC 70
Query: 466 EPCYINTL-EQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSL---DGIPFTVDAGGL 521
Y +C+ C I ++ A G+ YHP CF C +C + D + F+
Sbjct: 71 TQDYQQLYGTRCDSCRDFITGEVISALGRTYHPKCFVCSLCRKPFPIGDKVTFSGKECVC 130
Query: 522 IHCIEDFHK------KFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC--- 572
C + + C+ CKE I GQ ++ALD+ +HV C++C+ C
Sbjct: 131 QTCSQSMASSKPIKIRGPSHCAGCKEEI--KHGQS----LLALDKQWHVSCFKCQTCSVI 184
Query: 573 --GGLLSEGDNQGC---YPLDGHILCKTCN 597
G +S+ C Y I C+TC+
Sbjct: 185 LTGEYISKDGVPYCESDYHAQFGIKCETCD 214
Score = 66.6 bits (161), Expect = 6e-11
Identities = 35/93 (37%), Positives = 48/93 (51%), Gaps = 3/93 (3%)
Query: 416 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLE- 474
CA C E + G A+D+ +HV CF C C+ L G+ + + + YCE Y
Sbjct: 151 CAGCKEEIK-HGQSLLALDKQWHVSCFKCQTCSVILTGE-YISKDGVPYCESDYHAQFGI 208
Query: 475 QCNVCSKPIMERILRATGKAYHPHCFTCVMCHR 507
+C C + I R+L A GK YHP C CV CH+
Sbjct: 209 KCETCDRYISGRVLEAGGKHYHPTCARCVRCHQ 241
Score = 66.2 bits (160), Expect = 8e-11
Identities = 50/186 (26%), Positives = 74/186 (39%), Gaps = 33/186 (17%)
Query: 412 YFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYC-EPCYI 470
Y RC C + + GE +A+ + +H CF C +C +PF +K + + C
Sbjct: 78 YGTRCDSCRDFITGEVI--SALGRTYHPKCFVCSLCR-----KPFPIGDKVTFSGKECVC 130
Query: 471 NTLEQCNVCSKPIMER----------------ILRATGKAYHPHCFTCVMCHRSLDGIPF 514
T Q SKPI R L A K +H CF C C L G
Sbjct: 131 QTCSQSMASSKPIKIRGPSHCAGCKEEIKHGQSLLALDKQWHVSCFKCQTCSVILTGEYI 190
Query: 515 TVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGG 574
+ D G+ +C D+H +F +C C I + A + +H C RC C
Sbjct: 191 SKD--GVPYCESDYHAQFGIKCETCDRYISGRV-------LEAGGKHYHPTCARCVRCHQ 241
Query: 575 LLSEGD 580
+ +EG+
Sbjct: 242 MFTEGE 247
>gi|51173715 actin-binding LIM protein 1 isoform c [Homo sapiens]
Length = 746
Score = 77.4 bits (189), Expect = 4e-14
Identities = 53/211 (25%), Positives = 89/211 (42%), Gaps = 33/211 (15%)
Query: 408 PADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEP 467
P+++ C +CGE GE + FH+ CFTC +C L F+ + C
Sbjct: 31 PSEKPVIHCHKCGEPCKGEVL--RVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTL 88
Query: 468 CYINTL-EQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSL---DGIPFTVDAGGLIH 523
Y +C+ C + + ++ A GK YHP+CF C +C R D + F
Sbjct: 89 DYQRMYGTRCHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQL 148
Query: 524 CIEDFHKK-----FAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLS- 577
C + F+ C+ C I + ++ALD+ +H+ C++C+ CG +L+
Sbjct: 149 CAQPMSSSPKETTFSSNCAGCGRDI------KNGQALLALDKQWHLGCFKCKSCGKVLTG 202
Query: 578 -----------EGDNQGCYPLDGHILCKTCN 597
E D QG + + C+ C+
Sbjct: 203 EYISKDGAPYCEKDYQGLF----GVKCEACH 229
Score = 68.9 bits (167), Expect = 1e-11
Identities = 51/181 (28%), Positives = 75/181 (41%), Gaps = 24/181 (13%)
Query: 412 YFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLR-GQPFYAVEKKAYCEPCY- 469
Y RC CGE V GE TA+ + +H +CF C IC G + C+ C
Sbjct: 94 YGTRCHGCGEFVEGEVV--TALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQ 151
Query: 470 --------INTLEQCNVCSKPIME-RILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGG 520
C C + I + L A K +H CF C C + L G + D G
Sbjct: 152 PMSSSPKETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKD--G 209
Query: 521 LIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIV-ALDRDFHVHCYRCEDCGGLLSEG 579
+C +D+ F +C C + I T +++ A D+ +H C RC C + +EG
Sbjct: 210 APYCEKDYQGLFGVKCEACHQFI--------TGKVLEAGDKHYHPSCARCSRCNQMFTEG 261
Query: 580 D 580
+
Sbjct: 262 E 262
Score = 60.8 bits (146), Expect = 3e-09
Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 3/103 (2%)
Query: 406 NPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYC 465
+P + CA CG ++ G A+D+ +H+ CF C C L G+ + + + YC
Sbjct: 156 SPKETTFSSNCAGCGRDIKN-GQALLALDKQWHLGCFKCKSCGKVLTGE-YISKDGAPYC 213
Query: 466 EPCYINTLE-QCNVCSKPIMERILRATGKAYHPHCFTCVMCHR 507
E Y +C C + I ++L A K YHP C C C++
Sbjct: 214 EKDYQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQ 256
>gi|51173713 actin-binding LIM protein 1 isoform b [Homo sapiens]
Length = 718
Score = 77.4 bits (189), Expect = 4e-14
Identities = 53/211 (25%), Positives = 89/211 (42%), Gaps = 33/211 (15%)
Query: 408 PADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEP 467
P+++ C +CGE GE + FH+ CFTC +C L F+ + C
Sbjct: 31 PSEKPVIHCHKCGEPCKGEVL--RVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTL 88
Query: 468 CYINTL-EQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSL---DGIPFTVDAGGLIH 523
Y +C+ C + + ++ A GK YHP+CF C +C R D + F
Sbjct: 89 DYQRMYGTRCHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQL 148
Query: 524 CIEDFHKK-----FAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLS- 577
C + F+ C+ C I + ++ALD+ +H+ C++C+ CG +L+
Sbjct: 149 CAQPMSSSPKETTFSSNCAGCGRDI------KNGQALLALDKQWHLGCFKCKSCGKVLTG 202
Query: 578 -----------EGDNQGCYPLDGHILCKTCN 597
E D QG + + C+ C+
Sbjct: 203 EYISKDGAPYCEKDYQGLF----GVKCEACH 229
Score = 68.9 bits (167), Expect = 1e-11
Identities = 51/181 (28%), Positives = 75/181 (41%), Gaps = 24/181 (13%)
Query: 412 YFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLR-GQPFYAVEKKAYCEPCY- 469
Y RC CGE V GE TA+ + +H +CF C IC G + C+ C
Sbjct: 94 YGTRCHGCGEFVEGEVV--TALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQ 151
Query: 470 --------INTLEQCNVCSKPIME-RILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGG 520
C C + I + L A K +H CF C C + L G + D G
Sbjct: 152 PMSSSPKETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKD--G 209
Query: 521 LIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIV-ALDRDFHVHCYRCEDCGGLLSEG 579
+C +D+ F +C C + I T +++ A D+ +H C RC C + +EG
Sbjct: 210 APYCEKDYQGLFGVKCEACHQFI--------TGKVLEAGDKHYHPSCARCSRCNQMFTEG 261
Query: 580 D 580
+
Sbjct: 262 E 262
Score = 60.8 bits (146), Expect = 3e-09
Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 3/103 (2%)
Query: 406 NPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYC 465
+P + CA CG ++ G A+D+ +H+ CF C C L G+ + + + YC
Sbjct: 156 SPKETTFSSNCAGCGRDIKN-GQALLALDKQWHLGCFKCKSCGKVLTGE-YISKDGAPYC 213
Query: 466 EPCYINTLE-QCNVCSKPIMERILRATGKAYHPHCFTCVMCHR 507
E Y +C C + I ++L A K YHP C C C++
Sbjct: 214 EKDYQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQ 256
>gi|51173711 actin-binding LIM protein 1 isoform a [Homo sapiens]
Length = 778
Score = 77.4 bits (189), Expect = 4e-14
Identities = 53/211 (25%), Positives = 89/211 (42%), Gaps = 33/211 (15%)
Query: 408 PADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEP 467
P+++ C +CGE GE + FH+ CFTC +C L F+ + C
Sbjct: 91 PSEKPVIHCHKCGEPCKGEVL--RVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTL 148
Query: 468 CYINTL-EQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSL---DGIPFTVDAGGLIH 523
Y +C+ C + + ++ A GK YHP+CF C +C R D + F
Sbjct: 149 DYQRMYGTRCHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQL 208
Query: 524 CIEDFHKK-----FAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLS- 577
C + F+ C+ C I + ++ALD+ +H+ C++C+ CG +L+
Sbjct: 209 CAQPMSSSPKETTFSSNCAGCGRDI------KNGQALLALDKQWHLGCFKCKSCGKVLTG 262
Query: 578 -----------EGDNQGCYPLDGHILCKTCN 597
E D QG + + C+ C+
Sbjct: 263 EYISKDGAPYCEKDYQGLF----GVKCEACH 289
Score = 68.9 bits (167), Expect = 1e-11
Identities = 51/181 (28%), Positives = 75/181 (41%), Gaps = 24/181 (13%)
Query: 412 YFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLR-GQPFYAVEKKAYCEPCY- 469
Y RC CGE V GE TA+ + +H +CF C IC G + C+ C
Sbjct: 154 YGTRCHGCGEFVEGEVV--TALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQ 211
Query: 470 --------INTLEQCNVCSKPIME-RILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGG 520
C C + I + L A K +H CF C C + L G + D G
Sbjct: 212 PMSSSPKETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKD--G 269
Query: 521 LIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIV-ALDRDFHVHCYRCEDCGGLLSEG 579
+C +D+ F +C C + I T +++ A D+ +H C RC C + +EG
Sbjct: 270 APYCEKDYQGLFGVKCEACHQFI--------TGKVLEAGDKHYHPSCARCSRCNQMFTEG 321
Query: 580 D 580
+
Sbjct: 322 E 322
Score = 60.8 bits (146), Expect = 3e-09
Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 3/103 (2%)
Query: 406 NPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYC 465
+P + CA CG ++ G A+D+ +H+ CF C C L G+ + + + YC
Sbjct: 216 SPKETTFSSNCAGCGRDIKN-GQALLALDKQWHLGCFKCKSCGKVLTGE-YISKDGAPYC 273
Query: 466 EPCYINTLE-QCNVCSKPIMERILRATGKAYHPHCFTCVMCHR 507
E Y +C C + I ++L A K YHP C C C++
Sbjct: 274 EKDYQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQ 316
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.136 0.439
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,298,625
Number of Sequences: 37866
Number of extensions: 2611917
Number of successful extensions: 19856
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 259
Number of HSP's successfully gapped in prelim test: 1298
Number of HSP's that attempted gapping in prelim test: 10618
Number of HSP's gapped (non-prelim): 6391
length of query: 612
length of database: 18,247,518
effective HSP length: 108
effective length of query: 504
effective length of database: 14,157,990
effective search space: 7135626960
effective search space used: 7135626960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.