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Search of human proteins with 5031763
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5031763 hairy and enhancer of split 1 [Homo sapiens]
(280 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5031763 hairy and enhancer of split 1 [Homo sapiens] 575 e-164
gi|10863967 hairy and enhancer of split 4 isoform 2 [Homo sapiens] 236 2e-62
gi|216548627 hairy and enhancer of split 4 isoform 1 [Homo sapiens] 222 3e-58
gi|63055047 hairy and enhancer of split homolog 2 [Homo sapiens] 114 9e-26
gi|218751874 hairy and enhancer of split 6 isoform b [Homo sapiens] 99 4e-21
gi|21361763 hairy and enhancer of split 6 isoform a [Homo sapiens] 99 5e-21
gi|6912414 hairy/enhancer-of-split related with YRPW motif 2 [Ho... 94 1e-19
gi|105990528 hairy/enhancer-of-split related with YRPW motif 1 i... 94 1e-19
gi|105990526 hairy/enhancer-of-split related with YRPW motif 1 i... 91 9e-19
gi|7657154 hairy/enhancer-of-split related with YRPW motif-like ... 90 3e-18
gi|58219048 hairy and enhancer of split 5 [Homo sapiens] 78 1e-14
gi|66912172 hairy and enhancer of split 3 [Homo sapiens] 78 1e-14
gi|145207994 hairy and enhancer of split 7 [Homo sapiens] 73 3e-13
gi|13540521 basic helix-loop-helix domain containing, class B, 3... 64 2e-10
gi|4503299 basic helix-loop-helix family, member e40 [Homo sapiens] 62 6e-10
gi|4557317 annexin A11 [Homo sapiens] 56 4e-08
gi|22165433 annexin A11 [Homo sapiens] 56 4e-08
gi|22165431 annexin A11 [Homo sapiens] 56 4e-08
gi|71274142 HES/HEY-like transcription factor [Homo sapiens] 52 4e-07
gi|11386183 WAS protein family, member 2 [Homo sapiens] 52 8e-07
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 52 8e-07
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap... 51 1e-06
gi|119829187 alpha 1 type XVII collagen [Homo sapiens] 50 2e-06
gi|5032069 splicing factor 3b, subunit 4 [Homo sapiens] 49 4e-06
gi|33356148 formin-like 1 [Homo sapiens] 49 5e-06
gi|157168329 formin 1 [Homo sapiens] 49 6e-06
gi|170016069 zinc finger, CCHC domain containing 2 [Homo sapiens] 48 1e-05
gi|47132519 Ras association and pleckstrin homology domains 1 is... 47 1e-05
gi|210032580 SET domain containing 1B [Homo sapiens] 47 1e-05
gi|145309324 FH2 domain containing 1 [Homo sapiens] 47 2e-05
>gi|5031763 hairy and enhancer of split 1 [Homo sapiens]
Length = 280
Score = 575 bits (1481), Expect = e-164
Identities = 280/280 (100%), Positives = 280/280 (100%)
Query: 1 MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTL 60
MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTL
Sbjct: 1 MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTL 60
Query: 61 ILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNE 120
ILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNE
Sbjct: 61 ILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNE 120
Query: 121 VTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAP 180
VTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAP
Sbjct: 121 VTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAP 180
Query: 181 FAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAH 240
FAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAH
Sbjct: 181 FAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAH 240
Query: 241 SGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRPWRN 280
SGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRPWRN
Sbjct: 241 SGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRPWRN 280
>gi|10863967 hairy and enhancer of split 4 isoform 2 [Homo sapiens]
Length = 221
Score = 236 bits (602), Expect = 2e-62
Identities = 129/217 (59%), Positives = 151/217 (69%), Gaps = 17/217 (7%)
Query: 1 MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTL 60
M AD K S+SP+A PAS + TPDKP++A+EHRKSSKP+MEKRRRARINESL+QLKTL
Sbjct: 1 MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKSSKPVMEKRRRARINESLAQLKTL 60
Query: 61 ILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNE 120
ILDAL+K+SSRHSKLEKADILEMTV+HLR+L+R Q+TAALS DP+VLGKYRAGF EC+ E
Sbjct: 61 ILDALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAALSADPAVLGKYRAGFHECLAE 120
Query: 121 VTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPP---------P 171
V RFL+ CEGV +VR+RLLGHLA C+ Q+ P PA A P P P
Sbjct: 121 VNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSRRPASLSPAAPAEAPAPEVYAGRPLLP 180
Query: 172 GPGGPQHAPFAPPPPL------VPIPGGAAPPPGGAP 202
GGP P PP L +P A P G P
Sbjct: 181 SLGGP--FPLLAPPLLPGLTRALPAAPRAGPQGPGGP 215
>gi|216548627 hairy and enhancer of split 4 isoform 1 [Homo sapiens]
Length = 247
Score = 222 bits (565), Expect = 3e-58
Identities = 129/243 (53%), Positives = 151/243 (62%), Gaps = 43/243 (17%)
Query: 1 MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRK------------------------ 36
M AD K S+SP+A PAS + TPDKP++A+EHRK
Sbjct: 1 MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKVGSRPGVRGATGGREGRGTQPVPD 60
Query: 37 --SSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRA 94
SSKP+MEKRRRARINESL+QLKTLILDAL+K+SSRHSKLEKADILEMTV+HLR+L+R
Sbjct: 61 PQSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRV 120
Query: 95 QMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMT 154
Q+TAALS DP+VLGKYRAGF EC+ EV RFL+ CEGV +VR+RLLGHLA C+ Q+
Sbjct: 121 QVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSR 180
Query: 155 YPGQPHPALQAPPPPP---------PGPGGPQHAPFAPPPPL------VPIPGGAAPPPG 199
P PA A P P P GGP P PP L +P A P
Sbjct: 181 RPASLSPAAPAEAPAPEVYAGRPLLPSLGGP--FPLLAPPLLPGLTRALPAAPRAGPQGP 238
Query: 200 GAP 202
G P
Sbjct: 239 GGP 241
>gi|63055047 hairy and enhancer of split homolog 2 [Homo sapiens]
Length = 173
Score = 114 bits (285), Expect = 9e-26
Identities = 72/175 (41%), Positives = 92/175 (52%), Gaps = 12/175 (6%)
Query: 25 PDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMT 84
P + A+E RKS KP++EKRRRARIN+SLSQLK LIL L +++S SKLEKAD+LEMT
Sbjct: 4 PRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMT 63
Query: 85 VKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLA 144
V+ L+ L + A P YR G+S C+ + R L C + V RLL HL
Sbjct: 64 VRFLQELPASSWPTAA---PLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHL- 119
Query: 145 NCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPG 199
+ + T G P P P P AP P P+P +PP G
Sbjct: 120 --WRRAASATLDGGRAGDSSGPSAPAPAPAS------APEPASAPVPSPPSPPCG 166
>gi|218751874 hairy and enhancer of split 6 isoform b [Homo sapiens]
Length = 222
Score = 99.0 bits (245), Expect = 4e-21
Identities = 75/247 (30%), Positives = 110/247 (44%), Gaps = 53/247 (21%)
Query: 35 RKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRA 94
RK+ KP++EK+RRARINESL +L+ L+ A +KLE A++LE+TV+ ++ + R
Sbjct: 26 RKARKPLVEKKRRARINESLQELRLLLAGA-------EAKLENAEVLELTVRRVQGVLRG 78
Query: 95 QMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMT 154
+ ++ AG+ +CM+EV F+STC+ ++ V LL HL M +
Sbjct: 79 RAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSS 138
Query: 155 YPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAK 214
+ AL PP P G P A P PIP + P PG C +A EA
Sbjct: 139 FQDLLGDALAGPPRAPGRSGWP-----AGGAPGSPIP--SPPGPGDDLCSDLEEAPEA-- 189
Query: 215 VFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTAD-- 272
++ AP + GP+ V + G TA
Sbjct: 190 -----ELSQAP-----------------------------AEGPDLVPAALGSLTTAQIA 215
Query: 273 -SMWRPW 278
S+WRPW
Sbjct: 216 RSVWRPW 222
>gi|21361763 hairy and enhancer of split 6 isoform a [Homo sapiens]
Length = 224
Score = 98.6 bits (244), Expect = 5e-21
Identities = 75/247 (30%), Positives = 110/247 (44%), Gaps = 51/247 (20%)
Query: 35 RKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRA 94
RK+ KP++EK+RRARINESL +L+ L+ A +KLE A++LE+TV+ ++ + R
Sbjct: 26 RKARKPLVEKKRRARINESLQELRLLLAGA-----EVQAKLENAEVLELTVRRVQGVLRG 80
Query: 95 QMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMT 154
+ ++ AG+ +CM+EV F+STC+ ++ V LL HL M +
Sbjct: 81 RAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSS 140
Query: 155 YPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAK 214
+ AL PP P G P A P PIP + P PG C +A EA
Sbjct: 141 FQDLLGDALAGPPRAPGRSGWP-----AGGAPGSPIP--SPPGPGDDLCSDLEEAPEA-- 191
Query: 215 VFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTAD-- 272
++ AP + GP+ V + G TA
Sbjct: 192 -----ELSQAP-----------------------------AEGPDLVPAALGSLTTAQIA 217
Query: 273 -SMWRPW 278
S+WRPW
Sbjct: 218 RSVWRPW 224
>gi|6912414 hairy/enhancer-of-split related with YRPW motif 2 [Homo
sapiens]
Length = 337
Score = 94.4 bits (233), Expect = 1e-19
Identities = 94/301 (31%), Positives = 123/301 (40%), Gaps = 56/301 (18%)
Query: 26 DKPKTASE--HRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEM 83
+ P T S+ RK + I+EKRRR RIN SLS+L+ L+ A +K S +KLEKA+IL+M
Sbjct: 38 NSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGS--AKLEKAEILQM 95
Query: 84 TVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTE--VRTRLLG 141
TV HL+ LQ + GF EC+ EV R+LS+ EG+++ +R RL+
Sbjct: 96 TVDHLKMLQATGGKGYFDAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVS 155
Query: 142 HLANCMTQINAMT---------YPGQPH---------PA-----------------LQAP 166
HL+ C TQ A +P PH PA L
Sbjct: 156 HLSTCATQREAAAMTSSMAHHHHPLHPHHWAAAFHHLPAALLQPNGLHASESTPCRLSTT 215
Query: 167 PPPPPGPGGP------QHAPFAPPPPLVPIPGGAAPPPGGAPCKLGS--QAGEAAKVFGG 218
PP G HA A P PP + L + A AA
Sbjct: 216 SEVPPAHGSALLTATFAHADSALRMPSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAAA 275
Query: 219 FQVVPAPDGQFAFLIPNGAFA-HSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRP 277
+ G F L PN A A + I S S TS SP S T + +RP
Sbjct: 276 HSFPLSFAGAFPMLPPNAAAAVAAATAISPPLSVSATS------SPQQTSSGTNNKPYRP 329
Query: 278 W 278
W
Sbjct: 330 W 330
>gi|105990528 hairy/enhancer-of-split related with YRPW motif 1
isoform a [Homo sapiens]
Length = 304
Score = 94.0 bits (232), Expect = 1e-19
Identities = 92/283 (32%), Positives = 127/283 (44%), Gaps = 58/283 (20%)
Query: 28 PKTASE--HRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTV 85
P T+S+ RK + I+EKRRR RIN SLS+L+ L+ A +K S +KLEKA+IL+MTV
Sbjct: 41 PTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGS--AKLEKAEILQMTV 98
Query: 86 KHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTE--VRTRLLGHL 143
HL+ L A + GF EC+ EV R+LS EG++ +R RL+ HL
Sbjct: 99 DHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHL 158
Query: 144 ANCMTQINAMT--YPGQPHPALQAPPPPPPGPGGP--QHAPFAPPPPLVPIPGGAAPPPG 199
N +Q A + + G H P G H P P L+P G
Sbjct: 159 NNYASQREAASGAHAGLGHI-----------PWGTVFGHHPHIAHPLLLPQNGHGNAGTT 207
Query: 200 GAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTS---- 255
+P + Q G + AP P+G+ GPV+PV TS S S
Sbjct: 208 ASPTEPHHQ-GRLGSAHPEAPALRAP--------PSGSL---GPVLPVVTSASKLSPPLL 255
Query: 256 ------------------VGPNAVSPSSGPSLTAD--SMWRPW 278
+ PNA+SPS+ P+ A+ +RPW
Sbjct: 256 SSVASLSAFPFSFGSFHLLSPNALSPSA-PTQAANLGKPYRPW 297
>gi|105990526 hairy/enhancer-of-split related with YRPW motif 1
isoform b [Homo sapiens]
Length = 308
Score = 91.3 bits (225), Expect = 9e-19
Identities = 91/285 (31%), Positives = 126/285 (44%), Gaps = 58/285 (20%)
Query: 28 PKTASE--HRKSSKPIMEKRRRARINESLSQLKTLILDALKKD--SSRHSKLEKADILEM 83
P T+S+ RK + I+EKRRR RIN SLS+L+ L+ A +K +KLEKA+IL+M
Sbjct: 41 PTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQM 100
Query: 84 TVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTE--VRTRLLG 141
TV HL+ L A + GF EC+ EV R+LS EG++ +R RL+
Sbjct: 101 TVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVS 160
Query: 142 HLANCMTQINAMT--YPGQPHPALQAPPPPPPGPGGP--QHAPFAPPPPLVPIPGGAAPP 197
HL N +Q A + + G H P G H P P L+P G
Sbjct: 161 HLNNYASQREAASGAHAGLGHI-----------PWGTVFGHHPHIAHPLLLPQNGHGNAG 209
Query: 198 PGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTS-- 255
+P + Q G + AP P+G+ GPV+PV TS S S
Sbjct: 210 TTASPTEPHHQ-GRLGSAHPEAPALRAP--------PSGSL---GPVLPVVTSASKLSPP 257
Query: 256 --------------------VGPNAVSPSSGPSLTAD--SMWRPW 278
+ PNA+SPS+ P+ A+ +RPW
Sbjct: 258 LLSSVASLSAFPFSFGSFHLLSPNALSPSA-PTQAANLGKPYRPW 301
>gi|7657154 hairy/enhancer-of-split related with YRPW motif-like
[Homo sapiens]
Length = 328
Score = 89.7 bits (221), Expect = 3e-18
Identities = 86/288 (29%), Positives = 122/288 (42%), Gaps = 49/288 (17%)
Query: 2 PADIMEKNSSSPVA---ATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLK 58
P D+ ++ S +A +TP+S + + RK + I+EKRRR RIN SLS+L+
Sbjct: 17 PIDVGQEGQLSQMARPLSTPSS---------SQMQARKKRRGIIEKRRRDRINSSLSELR 67
Query: 59 TLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECM 118
L+ A +K S SKLEKA++L+MTV HL+ L T + GF EC+
Sbjct: 68 RLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFRECL 125
Query: 119 NEVTRFLSTCEGVNTE---VRTRLLGHLAN-------CMTQINAMTYPGQPH-------- 160
EV R+L EG ++ VR RLL HL + T + +P P
Sbjct: 126 TEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFFHSCPG 185
Query: 161 -PAL--------QAPPPPPPGPGGPQH-APFAPPPPLVPIPGGAAPPPGGAPCKLGSQAG 210
PAL + P P PG P + P PL G P G+ +
Sbjct: 186 LPALSNQLAILGRVPSPVLPGVSSPAYPIPALRTAPLRRATGIILPARRNVLPSRGASST 245
Query: 211 EAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGP 258
A+ P P + P+ A S + P+ S+S T GP
Sbjct: 246 RRARPLER-PATPVP------VAPSSRAARSSHIAPLLQSSSPTPPGP 286
Score = 31.6 bits (70), Expect = 0.81
Identities = 16/42 (38%), Positives = 20/42 (47%), Gaps = 6/42 (14%)
Query: 161 PALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAP 202
P LQ+ P PPGP G + VP P ++P P G P
Sbjct: 274 PLLQSSSPTPPGPTG------SAAYVAVPTPNSSSPGPAGRP 309
>gi|58219048 hairy and enhancer of split 5 [Homo sapiens]
Length = 166
Score = 77.8 bits (190), Expect = 1e-14
Identities = 62/188 (32%), Positives = 88/188 (46%), Gaps = 35/188 (18%)
Query: 18 PASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRH---SK 74
P++V PK E + KP++EK RR RIN S+ QLK L L+++ +RH SK
Sbjct: 3 PSTVAVELLSPK---EKNRLRKPVVEKMRRDRINSSIEQLKLL----LEQEFARHQPNSK 55
Query: 75 LEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTE 134
LEKADILEM V +L++ ++ A + S+ Y G+S C+ E +FL+ +T+
Sbjct: 56 LEKADILEMAVSYLKH---SKAFVAAAGPKSLHQDYSEGYSWCLQEAVQFLTLHAASDTQ 112
Query: 135 VRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGA 194
+ +LL H Q PP P P AP A PPP + A
Sbjct: 113 M--KLLYH--------------------FQRPPAAPAAPAKEPKAPGAAPPPALSAKATA 150
Query: 195 APPPGGAP 202
A P
Sbjct: 151 AAAAAHQP 158
>gi|66912172 hairy and enhancer of split 3 [Homo sapiens]
Length = 186
Score = 77.8 bits (190), Expect = 1e-14
Identities = 68/185 (36%), Positives = 95/185 (51%), Gaps = 20/185 (10%)
Query: 42 MEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALS 101
MEK+RRARIN SL QLK+L L+ R KLEKADILE++VK++R+LQ + L
Sbjct: 1 MEKKRRARINVSLEQLKSL-LEKHYSHQIRKRKLEKADILELSVKYMRSLQNS--LQGLW 57
Query: 102 TDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHP 161
P + +GF C+ V++ L + V + +R L+ A T +A GQ P
Sbjct: 58 PVPRG-AEQPSGFRSCLPGVSQLLRRGDEVGSGLRCPLVPESAAGSTMDSAGL--GQEAP 114
Query: 162 ALQAPP-----PPPPGPGGPQHAPFAPPPPLV---PIPGGAA--PPPGGAPCKLGSQAGE 211
AL P P P GGP+ +PPP L+ +PG +A PPP A + G
Sbjct: 115 ALFRPCTPAVWAPAPAAGGPR----SPPPLLLLPESLPGSSASVPPPQPASSRCAESPGL 170
Query: 212 AAKVF 216
+V+
Sbjct: 171 GLRVW 175
>gi|145207994 hairy and enhancer of split 7 [Homo sapiens]
Length = 225
Score = 72.8 bits (177), Expect = 3e-13
Identities = 55/186 (29%), Positives = 85/186 (45%), Gaps = 21/186 (11%)
Query: 36 KSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQ 95
K KP++EKRRR RIN SL +L+ L+L+ + + R+ KLEKA+ILE V +LR R +
Sbjct: 14 KMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVGYLRERSRVE 73
Query: 96 ----MTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQIN 151
+ + ++ Y +GF EC+ + F + R +L + ++
Sbjct: 74 PPGVPRSPVQDAEALASCYLSGFRECLLRLAAF---AHDASPAARAQL-------FSALH 123
Query: 152 AMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPP-----PPLVPIPGGAAPPPGGAPCKLG 206
P P P P PP P P AP P PP+ G +P +P
Sbjct: 124 GYLRPKPPRPKPVDPRPPAPRPSLDPAAPALGPALHQRPPV--HQGHPSPRCAWSPSLCS 181
Query: 207 SQAGEA 212
+AG++
Sbjct: 182 PRAGDS 187
Score = 30.8 bits (68), Expect = 1.4
Identities = 15/31 (48%), Positives = 15/31 (48%), Gaps = 2/31 (6%)
Query: 157 GQPHP--ALQAPPPPPPGPGGPQHAPFAPPP 185
G P P L PPPPP G AP PPP
Sbjct: 188 GAPAPLTGLLPPPPPPHRQDGAPKAPLPPPP 218
>gi|13540521 basic helix-loop-helix domain containing, class B, 3
[Homo sapiens]
Length = 482
Score = 63.5 bits (153), Expect = 2e-10
Identities = 59/163 (36%), Positives = 78/163 (47%), Gaps = 25/163 (15%)
Query: 41 IMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNL-----QRAQ 95
++EK+RR RINE ++QLK L+ + LK + H LEKA +LE+T+KHL+ L Q+ Q
Sbjct: 51 LIEKKRRDRINECIAQLKDLLPEHLKLTTLGH--LEKAVVLELTLKHLKALTALTEQQHQ 108
Query: 96 MTAAL--------STDPSVLGKYRAGFSECMNEVTRFLSTCEG-VNTEVR-TRLLGHLAN 145
AL S S L + +GF C EV ++LS E E R +L+ HL
Sbjct: 109 KIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRCVQLINHLHA 168
Query: 146 CMTQINAMTYPGQPHPALQAPPPP-PPGPGGPQHAPFAPPPPL 187
TQ P P L P G G P A A P L
Sbjct: 169 VATQF-------LPTPQLLTQQVPLSKGTGAPSAAGSAAAPCL 204
>gi|4503299 basic helix-loop-helix family, member e40 [Homo sapiens]
Length = 412
Score = 62.0 bits (149), Expect = 6e-10
Identities = 50/173 (28%), Positives = 84/173 (48%), Gaps = 25/173 (14%)
Query: 27 KPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVK 86
+ + + E K ++EK+RR RINE ++QLK L+ + LK + H LEKA +LE+T+K
Sbjct: 45 RSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGH--LEKAVVLELTLK 102
Query: 87 HLRNL-----QRAQMTAALSTD---PSVLGK--------YRAGFSECMNEVTRFLSTCEG 130
H++ L Q+ Q AL + + G+ + +GF C EV ++L+ E
Sbjct: 103 HVKALTNLIDQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHEN 162
Query: 131 VNTEVRTRLLGHLANCMTQI---NAMTYPGQPHPAL----QAPPPPPPGPGGP 176
++L+ HL ++++ P P P + + P P G GP
Sbjct: 163 TRDLKSSQLVTHLHRVVSELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGP 215
>gi|4557317 annexin A11 [Homo sapiens]
Length = 505
Score = 55.8 bits (133), Expect = 4e-08
Identities = 41/120 (34%), Positives = 49/120 (40%), Gaps = 7/120 (5%)
Query: 157 GQPHPALQAPPP----PPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEA 212
GQP A Q PP PPPG P P PP P P+PG PPPG P G+ G+
Sbjct: 91 GQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAPVPGQPMPPPGQQP--PGAYPGQP 148
Query: 213 AKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTAD 272
+ G VP P GQ + + SG V P S G +P P A+
Sbjct: 149 PVTYPGQPPVPLP-GQQQPVPSYPGYPGSGTVTPAVPPTQFGSRGTITDAPGFDPLRDAE 207
Score = 36.6 bits (83), Expect = 0.025
Identities = 20/46 (43%), Positives = 21/46 (45%), Gaps = 2/46 (4%)
Query: 155 YPGQPHPALQAPPP--PPPGPGGPQHAPFAPPPPLVPIPGGAAPPP 198
YPG P P PPP PPG Q P P VP+PG P P
Sbjct: 123 YPGAPVPGQPMPPPGQQPPGAYPGQPPVTYPGQPPVPLPGQQQPVP 168
Score = 33.5 bits (75), Expect = 0.21
Identities = 24/68 (35%), Positives = 27/68 (39%), Gaps = 3/68 (4%)
Query: 153 MTYPGQPH---PALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQA 209
+TYPGQP P Q P P PG G A PP G PG P +
Sbjct: 150 VTYPGQPPVPLPGQQQPVPSYPGYPGSGTVTPAVPPTQFGSRGTITDAPGFDPLRDAEVL 209
Query: 210 GEAAKVFG 217
+A K FG
Sbjct: 210 RKAMKGFG 217
Score = 33.1 bits (74), Expect = 0.28
Identities = 17/38 (44%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 153 MTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPI 190
M+YPG P P PP PG G A + PPP + PI
Sbjct: 1 MSYPGYPPPP-GGYPPAAPGGGPWGGAAYPPPPSMPPI 37
>gi|22165433 annexin A11 [Homo sapiens]
Length = 505
Score = 55.8 bits (133), Expect = 4e-08
Identities = 41/120 (34%), Positives = 49/120 (40%), Gaps = 7/120 (5%)
Query: 157 GQPHPALQAPPP----PPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEA 212
GQP A Q PP PPPG P P PP P P+PG PPPG P G+ G+
Sbjct: 91 GQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAPVPGQPMPPPGQQP--PGAYPGQP 148
Query: 213 AKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTAD 272
+ G VP P GQ + + SG V P S G +P P A+
Sbjct: 149 PVTYPGQPPVPLP-GQQQPVPSYPGYPGSGTVTPAVPPTQFGSRGTITDAPGFDPLRDAE 207
Score = 36.6 bits (83), Expect = 0.025
Identities = 20/46 (43%), Positives = 21/46 (45%), Gaps = 2/46 (4%)
Query: 155 YPGQPHPALQAPPP--PPPGPGGPQHAPFAPPPPLVPIPGGAAPPP 198
YPG P P PPP PPG Q P P VP+PG P P
Sbjct: 123 YPGAPVPGQPMPPPGQQPPGAYPGQPPVTYPGQPPVPLPGQQQPVP 168
Score = 33.5 bits (75), Expect = 0.21
Identities = 24/68 (35%), Positives = 27/68 (39%), Gaps = 3/68 (4%)
Query: 153 MTYPGQPH---PALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQA 209
+TYPGQP P Q P P PG G A PP G PG P +
Sbjct: 150 VTYPGQPPVPLPGQQQPVPSYPGYPGSGTVTPAVPPTQFGSRGTITDAPGFDPLRDAEVL 209
Query: 210 GEAAKVFG 217
+A K FG
Sbjct: 210 RKAMKGFG 217
Score = 33.1 bits (74), Expect = 0.28
Identities = 17/38 (44%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 153 MTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPI 190
M+YPG P P PP PG G A + PPP + PI
Sbjct: 1 MSYPGYPPPP-GGYPPAAPGGGPWGGAAYPPPPSMPPI 37
>gi|22165431 annexin A11 [Homo sapiens]
Length = 505
Score = 55.8 bits (133), Expect = 4e-08
Identities = 41/120 (34%), Positives = 49/120 (40%), Gaps = 7/120 (5%)
Query: 157 GQPHPALQAPPP----PPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEA 212
GQP A Q PP PPPG P P PP P P+PG PPPG P G+ G+
Sbjct: 91 GQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAPVPGQPMPPPGQQP--PGAYPGQP 148
Query: 213 AKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTAD 272
+ G VP P GQ + + SG V P S G +P P A+
Sbjct: 149 PVTYPGQPPVPLP-GQQQPVPSYPGYPGSGTVTPAVPPTQFGSRGTITDAPGFDPLRDAE 207
Score = 36.6 bits (83), Expect = 0.025
Identities = 20/46 (43%), Positives = 21/46 (45%), Gaps = 2/46 (4%)
Query: 155 YPGQPHPALQAPPP--PPPGPGGPQHAPFAPPPPLVPIPGGAAPPP 198
YPG P P PPP PPG Q P P VP+PG P P
Sbjct: 123 YPGAPVPGQPMPPPGQQPPGAYPGQPPVTYPGQPPVPLPGQQQPVP 168
Score = 33.5 bits (75), Expect = 0.21
Identities = 24/68 (35%), Positives = 27/68 (39%), Gaps = 3/68 (4%)
Query: 153 MTYPGQPH---PALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQA 209
+TYPGQP P Q P P PG G A PP G PG P +
Sbjct: 150 VTYPGQPPVPLPGQQQPVPSYPGYPGSGTVTPAVPPTQFGSRGTITDAPGFDPLRDAEVL 209
Query: 210 GEAAKVFG 217
+A K FG
Sbjct: 210 RKAMKGFG 217
Score = 33.1 bits (74), Expect = 0.28
Identities = 17/38 (44%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 153 MTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPI 190
M+YPG P P PP PG G A + PPP + PI
Sbjct: 1 MSYPGYPPPP-GGYPPAAPGGGPWGGAAYPPPPSMPPI 37
>gi|71274142 HES/HEY-like transcription factor [Homo sapiens]
Length = 327
Score = 52.4 bits (124), Expect = 4e-07
Identities = 59/213 (27%), Positives = 79/213 (37%), Gaps = 51/213 (23%)
Query: 38 SKPIMEKRRRARINESLSQLKTLILDALKKDSSRHS------------------------ 73
S ++EKRRR RIN L++L + AL K
Sbjct: 58 SHKVIEKRRRDRINRCLNELGKTVPMALAKQGEPQEALAQIRSRVRSLVLSSATVPDQQA 117
Query: 74 ---------------KLEKADILEMTVKHLRNLQRAQMTAALSTD---PSVLGKYRAGFS 115
KLEKA+ILEMTV++LR L A + G+
Sbjct: 118 LGRCEGPFLLLQSSGKLEKAEILEMTVQYLRALHSADFPRGREKAELLAEFANYFHYGYH 177
Query: 116 ECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPP---PPG 172
ECM + +L+T E + T+ T+ LA ++ P P P P P
Sbjct: 178 ECMKNLVHYLTTVERMETK-DTKYARILAFLQSKARLGAEPAFP-PLGSLPEPDFSYQLH 235
Query: 173 PGGPQHAPFAPPPPLV-PIPGGAAP---PPGGA 201
P GP+ A +P V P GA P PPG A
Sbjct: 236 PAGPEFAGHSPGEAAVFPQGSGAGPFPWPPGAA 268
>gi|11386183 WAS protein family, member 2 [Homo sapiens]
Length = 498
Score = 51.6 bits (122), Expect = 8e-07
Identities = 24/44 (54%), Positives = 24/44 (54%), Gaps = 2/44 (4%)
Query: 159 PHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAP 202
PHP APPPPPP P P PPPPL GGA PPP P
Sbjct: 357 PHPDFAAPPPPPPPPAADY--PTLPPPPLSQPTGGAPPPPPPPP 398
Score = 44.7 bits (104), Expect = 9e-05
Identities = 23/48 (47%), Positives = 24/48 (50%), Gaps = 1/48 (2%)
Query: 156 PGQPHPALQAPPPPPP-GPGGPQHAPFAPPPPLVPIPGGAAPPPGGAP 202
P P P + PPPPPP G G P P PP P P AAPPP P
Sbjct: 323 PPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPP 370
Score = 39.3 bits (90), Expect = 0.004
Identities = 23/52 (44%), Positives = 23/52 (44%), Gaps = 10/52 (19%)
Query: 152 AMTYPGQPHPALQ-----APPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPP 198
A YP P P L APPPPPP P P PPPP G A PP
Sbjct: 372 AADYPTLPPPPLSQPTGGAPPPPPPPP-----PPGPPPPPFTGADGQPAIPP 418
Score = 37.7 bits (86), Expect = 0.011
Identities = 20/43 (46%), Positives = 20/43 (46%), Gaps = 2/43 (4%)
Query: 156 PGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPP 198
P P PA P PPP P APPPP P P G PPP
Sbjct: 366 PPPPPPAADYPTLPPPPLSQPTGG--APPPPPPPPPPGPPPPP 406
Score = 37.4 bits (85), Expect = 0.015
Identities = 35/116 (30%), Positives = 44/116 (37%), Gaps = 18/116 (15%)
Query: 151 NAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAG 210
+++ P P PA PP P PG P APPPP P+ G PPP P GS
Sbjct: 292 SSVVSPSHPPPAPPLGSPPGPKPGFAP--PPAPPPPPPPMIGIPPPPP---PVGFGSPG- 345
Query: 211 EAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSG 266
P P +F P+ FA P P ++ T P P+ G
Sbjct: 346 -----------TPPPPSPPSF-PPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGG 389
>gi|21071077 dishevelled-associated activator of morphogenesis 1
[Homo sapiens]
Length = 1078
Score = 51.6 bits (122), Expect = 8e-07
Identities = 30/61 (49%), Positives = 31/61 (50%), Gaps = 11/61 (18%)
Query: 156 PGQPHPA-----LQAPPPPPPGPGG------PQHAPFAPPPPLVPIPGGAAPPPGGAPCK 204
PG P P+ L PPPPPP PGG P P PPPP P P GA PP GAP
Sbjct: 536 PGGPFPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMG 595
Query: 205 L 205
L
Sbjct: 596 L 596
>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
sapiens]
Length = 505
Score = 51.2 bits (121), Expect = 1e-06
Identities = 42/111 (37%), Positives = 44/111 (39%), Gaps = 13/111 (11%)
Query: 164 QAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPG---GAPCKLGSQAGEAA----KVF 216
QAPPPPPP GGP PPPP P G PPP GAP S+A AA
Sbjct: 275 QAPPPPPPSRGGP------PPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPS 328
Query: 217 GGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGP 267
VP P + P A S P P S VGP A P P
Sbjct: 329 RPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPP 379
Score = 46.2 bits (108), Expect = 3e-05
Identities = 23/47 (48%), Positives = 23/47 (48%), Gaps = 2/47 (4%)
Query: 156 PGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAP 202
P P A PPPPPP G P APPPP P P PPP G P
Sbjct: 348 PALPSSAPSGPPPPPPSVLGV--GPVAPPPPPPPPPPPGPPPPPGLP 392
Score = 38.5 bits (88), Expect = 0.007
Identities = 21/52 (40%), Positives = 24/52 (46%), Gaps = 9/52 (17%)
Query: 156 PGQPHPALQAPPPPPPG-------PGGPQHAPFAPPPPLVP--IPGGAAPPP 198
P P A A PPPPP P P + + PPPP +P P G PPP
Sbjct: 311 PPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPP 362
Score = 35.4 bits (80), Expect = 0.056
Identities = 21/52 (40%), Positives = 22/52 (42%), Gaps = 9/52 (17%)
Query: 156 PGQPHPALQAPPPPPPG------PGGPQHAPFA---PPPPLVPIPGGAAPPP 198
P P P + PPPPP P P AP A PPPP P PPP
Sbjct: 288 PPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPP 339
>gi|119829187 alpha 1 type XVII collagen [Homo sapiens]
Length = 1497
Score = 50.1 bits (118), Expect = 2e-06
Identities = 40/140 (28%), Positives = 49/140 (35%), Gaps = 25/140 (17%)
Query: 153 MTYPGQPHPALQAPPPPPPGPGGP--------------------QHAPFAPPPPLVPIPG 192
+T PG P P PP PPG GP P PP P +P P
Sbjct: 817 LTVPGPPGPPGAMGPPGPPGAPGPAGPAGLPGHQEVLNLQGPPGPPGPRGPPGPSIPGPP 876
Query: 193 GAAPPPG----GAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPV-IPV 247
G PPG G P GS + G P P G P G H G +P
Sbjct: 877 GPRGPPGEGLPGPPGPPGSFLSNSETFLSGPPGPPGPPGPKGDQGPPGPRGHQGEQGLPG 936
Query: 248 YTSNSGTSVGPNAVSPSSGP 267
++++ +S G N P P
Sbjct: 937 FSTSGSSSFGLNLQGPPGPP 956
Score = 32.0 bits (71), Expect = 0.62
Identities = 35/116 (30%), Positives = 43/116 (37%), Gaps = 13/116 (11%)
Query: 157 GQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVF 216
G P P+ P GP GPQ P P P G P GAP K+ + G +
Sbjct: 767 GPPGPSGDPGKPGLTGPQGPQGLPGTPGRP------GIKGEP-GAPGKIVTSEGSSMLTV 819
Query: 217 GGFQVVPAPDGQFAFLIPNGAFAHSGPV-IPVYTS--NSGTSVGPNAVSPSSGPSL 269
G P P G P GA +GP +P + N GP GPS+
Sbjct: 820 PG---PPGPPGAMGPPGPPGAPGPAGPAGLPGHQEVLNLQGPPGPPGPRGPPGPSI 872
Score = 30.8 bits (68), Expect = 1.4
Identities = 26/85 (30%), Positives = 35/85 (41%), Gaps = 18/85 (21%)
Query: 167 PPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVF-GGFQVVPAP 225
PP PPGP GP+ P +PG P G S+ G ++ ++ G P P
Sbjct: 952 PPGPPGPQGPKGDKGDP-----GVPGALGIPSG------PSEGGSSSTMYVSGPPGPPGP 1000
Query: 226 DGQFAFLIPNGAFAHSGPVIPVYTS 250
G P G+ + SG I Y S
Sbjct: 1001 PG------PPGSISSSGQEIQQYIS 1019
Score = 28.5 bits (62), Expect = 6.8
Identities = 28/107 (26%), Positives = 37/107 (34%), Gaps = 21/107 (19%)
Query: 157 GQPHPALQAPPPPPPGPGGPQHA------------------PFAPPPPLVPIPGGAAPPP 198
G + PP PP PG P + F P PP P P G PP
Sbjct: 1170 GSEFRGIVGPPGPPGPPGIPGNVWSSISVEDLSSYLHTAGLSFIPGPPGPPGPPGPRGPP 1229
Query: 199 GGAPCKLGSQAGEAAKVFGG--FQVVPAPDGQFAFLIPNGAFAHSGP 243
G + L + A E + F + +PD + + P G GP
Sbjct: 1230 GVSGA-LATYAAENSDSFRSELISYLTSPDVRSFIVGPPGPPGPQGP 1275
>gi|5032069 splicing factor 3b, subunit 4 [Homo sapiens]
Length = 424
Score = 49.3 bits (116), Expect = 4e-06
Identities = 22/47 (46%), Positives = 23/47 (48%)
Query: 156 PGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAP 202
PG P P PP PPPG P P PPPP+ P G PP G P
Sbjct: 235 PGMPPPGSFPPPVPPPGALPPGIPPAMPPPPMPPGAAGHGPPSAGTP 281
Score = 35.8 bits (81), Expect = 0.043
Identities = 37/135 (27%), Positives = 44/135 (32%), Gaps = 22/135 (16%)
Query: 151 NAMTYPGQPHPALQAPPPPP--------------PGPGGPQHAPFAPP-PPLVPIPGG-- 193
N ++ +PH PPPP P PG P F PP PP +P G
Sbjct: 199 NPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPPPGMPPPGSFPPPVPPPGALPPGIP 258
Query: 194 -AAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNS 252
A PPP P G A G P P G H G +
Sbjct: 259 PAMPPPPMPPGAAGHGPPSAGTPGAGH---PGHGHSHPHPFPPGGMPHPGMSQMQLAHHG 315
Query: 253 GTSVG-PNAVSPSSG 266
+G P+A P SG
Sbjct: 316 PHGLGHPHAGPPGSG 330
Score = 32.3 bits (72), Expect = 0.47
Identities = 26/73 (35%), Positives = 27/73 (36%), Gaps = 29/73 (39%)
Query: 156 PGQPHPALQAPPP---PPPGP--GGPQHAP-------FAPPPPLVPIPG----------- 192
PG PHP PPP PP GP G P P PPPL+P G
Sbjct: 339 PGMPHPG---PPPMGMPPRGPPFGSPMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPYG 395
Query: 193 ---GAAPPPGGAP 202
G PPP P
Sbjct: 396 YQRGPLPPPRPTP 408
Score = 32.0 bits (71), Expect = 0.62
Identities = 19/48 (39%), Positives = 22/48 (45%), Gaps = 9/48 (18%)
Query: 155 YPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAP 202
+ G P Q PP PPPG P PPP+ P G PP G+P
Sbjct: 323 HAGPPGSGGQPPPRPPPG------MPHPGPPPMGMPPRG---PPFGSP 361
Score = 29.3 bits (64), Expect = 4.0
Identities = 21/58 (36%), Positives = 22/58 (37%), Gaps = 14/58 (24%)
Query: 153 MTYPGQ--PHPALQAPP---------PPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPG 199
M +PG PH PP PP P P G Q P PP P P PP G
Sbjct: 362 MGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPR---PTPRPPVPPRG 416
Score = 28.5 bits (62), Expect = 6.8
Identities = 20/51 (39%), Positives = 22/51 (43%), Gaps = 12/51 (23%)
Query: 157 GQPHPALQAPPPPPPGPG------GPQHAPFAPP---PPLVPIPGGAAPPP 198
GQP P PPP P PG P+ PF P P +P G PPP
Sbjct: 331 GQPPPR---PPPGMPHPGPPPMGMPPRGPPFGSPMGHPGPMPPHGMRGPPP 378
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 48.9 bits (115), Expect = 5e-06
Identities = 25/56 (44%), Positives = 26/56 (46%), Gaps = 6/56 (10%)
Query: 156 PGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGE 211
P P P PPPPPP P P PPPP P PPPGG P LG + E
Sbjct: 576 PAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPP------PPPGGPPDALGRRDSE 625
Score = 48.1 bits (113), Expect = 8e-06
Identities = 23/43 (53%), Positives = 26/43 (60%), Gaps = 3/43 (6%)
Query: 158 QPHPALQAPPPPPPGPG--GPQHAPFAPPPPLVPIPGGAAPPP 198
+P P APPPPPP PG PQ AP + PP P+PG PPP
Sbjct: 535 EPAPGA-APPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPP 576
Score = 32.0 bits (71), Expect = 0.62
Identities = 17/47 (36%), Positives = 21/47 (44%), Gaps = 3/47 (6%)
Query: 159 PHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAP---PPGGAP 202
P P + P P + AP A PPP P+PG +P PP P
Sbjct: 517 PTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPP 563
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 48.5 bits (114), Expect = 6e-06
Identities = 24/48 (50%), Positives = 25/48 (52%), Gaps = 1/48 (2%)
Query: 156 PGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPP-PGGAP 202
P P L PPPPPP P A PPPP P+P APP PGG P
Sbjct: 673 PVSAGPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPP 720
Score = 46.2 bits (108), Expect = 3e-05
Identities = 22/49 (44%), Positives = 25/49 (51%)
Query: 166 PPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAK 214
PPPPPP P P PPP P PG A PPP G LGS + + +
Sbjct: 701 PPPPPPLPNSPAPPNPGGPPPAPPPPGLAPPPPPGLFFGLGSSSSQCPR 749
Score = 43.9 bits (102), Expect = 2e-04
Identities = 26/66 (39%), Positives = 29/66 (43%), Gaps = 2/66 (3%)
Query: 162 ALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQV 221
+L PP PP GP P PPPP +P P A PPP P L + A GG
Sbjct: 664 SLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPN--SPAPPNPGGPPP 721
Query: 222 VPAPDG 227
P P G
Sbjct: 722 APPPPG 727
Score = 30.0 bits (66), Expect = 2.4
Identities = 36/146 (24%), Positives = 49/146 (33%), Gaps = 11/146 (7%)
Query: 124 FLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAP 183
FL CE + R+ L ++ ++ ++ P H + A P G Q P
Sbjct: 589 FLKPCESESKTTRSNQLVPKKLNISSLSQLSPPND-HKDIHAALQPMEGMASNQQKALPP 647
Query: 184 PPPLVPIPGGAAPPPGGAPCKLG--SQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHS 241
PP + PPP P LG S A V G + P P P+ A
Sbjct: 648 PPASI-------PPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSA-GPP 699
Query: 242 GPVIPVYTSNSGTSVGPNAVSPSSGP 267
P P NS P P+ P
Sbjct: 700 PPPPPPPLPNSPAPPNPGGPPPAPPP 725
>gi|170016069 zinc finger, CCHC domain containing 2 [Homo sapiens]
Length = 1178
Score = 47.8 bits (112), Expect = 1e-05
Identities = 23/46 (50%), Positives = 23/46 (50%), Gaps = 5/46 (10%)
Query: 166 PPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPP-PGGAPCKLGSQAG 210
PPPPPP P GP P PPPP P G PP GGA G G
Sbjct: 43 PPPPPPPPAGPSRGPLPPPPP----PRGLGPPVAGGAAAGAGMPGG 84
Score = 30.8 bits (68), Expect = 1.4
Identities = 23/68 (33%), Positives = 36/68 (52%), Gaps = 2/68 (2%)
Query: 50 INESLSQLKT-LILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLG 108
IN S LKT IL+ LK+DSS S E+ D+L+ + H ++ ++ + + T S L
Sbjct: 469 INNLQSSLKTSKILEHLKEDSSEASSQEE-DVLQHAIIHKKHTGKSPIVNNIGTSCSPLD 527
Query: 109 KYRAGFSE 116
+SE
Sbjct: 528 GLTMQYSE 535
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 47.4 bits (111), Expect = 1e-05
Identities = 40/118 (33%), Positives = 45/118 (38%), Gaps = 34/118 (28%)
Query: 158 QPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFG 217
QP P L PPPPPP P P PPPP P+P +AP AG AA +F
Sbjct: 623 QPSPPLPPPPPPPPPPPPP------PPPPPPPLPSQSAP-----------SAGSAAPMFV 665
Query: 218 GFQVVPAPDGQFAFLIPNGAFAHSG-----PVIPVYTSNS---GTSVGPNAVSPSSGP 267
+ + A HSG P PV S S V PN V P P
Sbjct: 666 KYSTITR---------LQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPP 714
Score = 40.8 bits (94), Expect = 0.001
Identities = 31/93 (33%), Positives = 40/93 (43%), Gaps = 12/93 (12%)
Query: 159 PHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGA---PCKLGSQAGEAAKV 215
P P+ PPPPP + + PPPP P+P PPP A P K GS + +K
Sbjct: 910 PVPSPDFPPPPP------ESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKT 963
Query: 216 F--GGFQVVPAPDGQFAFLIPNGAFAHSGPVIP 246
GG + P P + +GA H P P
Sbjct: 964 SSPGGKKPPPTPQRNSSIKSSSGA-EHPEPKRP 995
Score = 35.0 bits (79), Expect = 0.073
Identities = 17/51 (33%), Positives = 22/51 (43%), Gaps = 3/51 (5%)
Query: 151 NAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPP---PPLVPIPGGAAPPP 198
+++ +P P + APPPPPP P P PGG PPP
Sbjct: 923 SSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPP 973
Score = 34.7 bits (78), Expect = 0.096
Identities = 17/41 (41%), Positives = 21/41 (51%), Gaps = 1/41 (2%)
Query: 159 PHPALQAPPPPPPGP-GGPQHAPFAPPPPLVPIPGGAAPPP 198
P+ + PPPPPP P G A P P +P +APPP
Sbjct: 705 PNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPP 745
Score = 34.7 bits (78), Expect = 0.096
Identities = 19/43 (44%), Positives = 23/43 (53%), Gaps = 4/43 (9%)
Query: 149 QINAMTYPGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIP 191
+I+ + + Q P PPPP P P PQ APP PLV IP
Sbjct: 748 KIHQVQHITQVAPPTPPPPPPIPAPLPPQ----APPKPLVTIP 786
Score = 34.7 bits (78), Expect = 0.096
Identities = 39/163 (23%), Positives = 50/163 (30%), Gaps = 33/163 (20%)
Query: 142 HLANCMTQINAMTYPGQPHPALQAPPPPPP---------------GPGGPQHAPFAPPPP 186
H +TQ+ T P P PP PP P Q AP P PP
Sbjct: 750 HQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPP 809
Query: 187 LVPI------------PGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIP 234
+ P P PP P L Q AK P+P ++
Sbjct: 810 VPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAK------PPPSPLSPVPSVVK 863
Query: 235 NGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWRP 277
A P P + P V+P S P++ A W+P
Sbjct: 864 QIASQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQP 906
Score = 31.2 bits (69), Expect = 1.1
Identities = 27/84 (32%), Positives = 29/84 (34%), Gaps = 24/84 (28%)
Query: 161 PALQAPPPPP----------PGPGGPQHAPF-APPPPL--------VPIPGGAAPPPGGA 201
P PPPPP P P P F APPPPL + PPP
Sbjct: 710 PPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPI 769
Query: 202 PCKLGSQAGEAAKVFGGFQVVPAP 225
P L QA V +PAP
Sbjct: 770 PAPLPPQAPPKPLV-----TIPAP 788
Score = 30.8 bits (68), Expect = 1.4
Identities = 18/41 (43%), Positives = 18/41 (43%), Gaps = 9/41 (21%)
Query: 156 PGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAP 196
P P P PPPPPP P Q AP A G AAP
Sbjct: 631 PPPPPPPPPPPPPPPPPPLPSQSAPSA---------GSAAP 662
Score = 29.3 bits (64), Expect = 4.0
Identities = 23/72 (31%), Positives = 28/72 (38%), Gaps = 6/72 (8%)
Query: 135 VRTRLLGHLANCMTQINAMTYPGQPHPALQAPPPPPP---GPGGPQHAPFAPPPPLVPIP 191
V+ + L N A+ P P P +Q+ P P G P PPPP P P
Sbjct: 665 VKYSTITRLQNASQHSGALFKPPTP-PVMQSQSVKPQILVPPNGVVPPPPPPPPP--PTP 721
Query: 192 GGAAPPPGGAPC 203
G A APC
Sbjct: 722 GSAMAQLKPAPC 733
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 47.4 bits (111), Expect = 1e-05
Identities = 21/45 (46%), Positives = 22/45 (48%), Gaps = 2/45 (4%)
Query: 156 PGQPHPALQAPPP--PPPGPGGPQHAPFAPPPPLVPIPGGAAPPP 198
P P P PPP PPP P P H PPP +P P G PPP
Sbjct: 696 PPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVPPPP 740
Score = 45.4 bits (106), Expect = 5e-05
Identities = 24/54 (44%), Positives = 25/54 (46%), Gaps = 8/54 (14%)
Query: 156 PGQPHPALQAPPPPPPGPGGPQHAPFAPPP-------PLVPIPGGAAPPPGGAP 202
PG P P PPPPPP PG P P PPP P V +P P P G P
Sbjct: 685 PGFP-PLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVP 737
Score = 40.8 bits (94), Expect = 0.001
Identities = 36/122 (29%), Positives = 42/122 (34%), Gaps = 26/122 (21%)
Query: 156 PGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPP------------GGAPC 203
P HPA+ PPPP P P G P PP P P P G P GG P
Sbjct: 716 PPPAHPAVTVPPPPLPAPPGVPPPPILPPLP--PFPPGLFPVMQVDMSHVLGGQWGGMPM 773
Query: 204 KLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVI--------PVYTSNSGTS 255
Q +++ G P P F+ A A +G P SNSG
Sbjct: 774 SFQMQTQVLSRLMTGQGACPYP----PFMAAAAAAASAGLQFVNLPPYRGPFSLSNSGPG 829
Query: 256 VG 257
G
Sbjct: 830 RG 831
Score = 33.1 bits (74), Expect = 0.28
Identities = 28/98 (28%), Positives = 38/98 (38%), Gaps = 15/98 (15%)
Query: 166 PPPPPPGPGGPQHAPFAPPPPLVPI-----------PGGAAPPPGGAPCKLGSQAGEAAK 214
P PPPP P PQ P PPPP+ P P A PP ++ + E AK
Sbjct: 1537 PAPPPPLP--PQPPPPPPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEVTEEYMELAK 1594
Query: 215 VFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNS 252
G ++ P + L+P P P++ S
Sbjct: 1595 SRGPWR--RPPKKRHEDLVPPAGSPELSPPQPLFRPRS 1630
Score = 32.0 bits (71), Expect = 0.62
Identities = 16/46 (34%), Positives = 21/46 (45%), Gaps = 4/46 (8%)
Query: 156 PGQPHPALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGA 201
P P P PPP PG P+ + PP ++ + G PP GA
Sbjct: 1459 PLLPAPLASCPPPMKRKPGRPRRS----PPSMLSLDGPLVRPPAGA 1500
Score = 29.6 bits (65), Expect = 3.1
Identities = 34/123 (27%), Positives = 45/123 (36%), Gaps = 23/123 (18%)
Query: 156 PGQPHPALQAPPPPPPGPGGPQHA-PFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAK 214
P P P PP PPP P + P PP PL A P P GS A +
Sbjct: 1280 PPLPPPRPPRPPSPPPEPETTDASHPSVPPEPL------AEDHPPHTPGLCGSLAKSQST 1333
Query: 215 VFGGFQVVPA-PDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADS 273
+ VPA P G+ + + S P +P G P+ PSL++
Sbjct: 1334 -----ETVPATPGGEPPLSGGSSGLSLSSPQVP----------GSPFSYPAPSPSLSSGG 1378
Query: 274 MWR 276
+ R
Sbjct: 1379 LPR 1381
>gi|145309324 FH2 domain containing 1 [Homo sapiens]
Length = 1143
Score = 47.0 bits (110), Expect = 2e-05
Identities = 30/79 (37%), Positives = 37/79 (46%), Gaps = 18/79 (22%)
Query: 142 HLANCMTQI------NAMTYPG----QPHPALQAPPPPPPGPGGP-----QHAPFAPP-P 185
H+ NC++ + N T PG Q P PPPPPP P P + P +PP P
Sbjct: 2 HVMNCVSLVSDKENGNIATAPGFMIGQTPPPAPPPPPPPPPPSPPCSCSREECPSSPPPP 61
Query: 186 PLVPIPG--GAAPPPGGAP 202
P P+PG PPP G P
Sbjct: 62 PPPPLPGEPPIPPPPPGLP 80
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,099,837
Number of Sequences: 37866
Number of extensions: 1107098
Number of successful extensions: 27147
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 785
Number of HSP's successfully gapped in prelim test: 983
Number of HSP's that attempted gapping in prelim test: 8964
Number of HSP's gapped (non-prelim): 10128
length of query: 280
length of database: 18,247,518
effective HSP length: 101
effective length of query: 179
effective length of database: 14,423,052
effective search space: 2581726308
effective search space used: 2581726308
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.