Search of human proteins with 5031737

Search of human proteins with 5031737

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
         (280 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...   551   e-157
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap...   437   e-123
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...   320   7e-88
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ...   258   3e-69
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...   244   5e-65
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]    110   1e-24
gi|40254992 carbonic reductase 4 [Homo sapiens]                        99   3e-21
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...    94   2e-19
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]           93   2e-19
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]     88   7e-18
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]              85   8e-17
gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]                 84   1e-16
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    82   4e-16
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]        80   2e-15
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          76   3e-14
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]      74   1e-13
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]       74   1e-13
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo...    72   4e-13
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [...    70   2e-12
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho...    70   2e-12
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho...    70   2e-12
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform...    69   3e-12
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]         69   5e-12
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi...    67   1e-11
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    67   1e-11
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]        67   2e-11
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]    66   3e-11
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    64   1e-10
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]         64   1e-10
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom...    63   3e-10

>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score =  551 bits (1421), Expect = e-157
 Identities = 280/280 (100%), Positives = 280/280 (100%)

Query: 1   MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDG 60
           MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDG
Sbjct: 1   MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDG 60

Query: 61  AHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCS 120
           AHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCS
Sbjct: 61  AHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCS 120

Query: 121 AGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVV 180
           AGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVV
Sbjct: 121 AGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVV 180

Query: 181 ALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHH 240
           ALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHH
Sbjct: 181 ALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHH 240

Query: 241 QLQRIGESEDCAGIVSFLCSPDASYVNGENIAVAGYSTRL 280
           QLQRIGESEDCAGIVSFLCSPDASYVNGENIAVAGYSTRL
Sbjct: 241 QLQRIGESEDCAGIVSFLCSPDASYVNGENIAVAGYSTRL 280


>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
           sapiens]
          Length = 300

 Score =  437 bits (1123), Expect = e-123
 Identities = 225/225 (100%), Positives = 225/225 (100%)

Query: 1   MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDG 60
           MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDG
Sbjct: 1   MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDG 60

Query: 61  AHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCS 120
           AHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCS
Sbjct: 61  AHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCS 120

Query: 121 AGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVV 180
           AGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVV
Sbjct: 121 AGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVV 180

Query: 181 ALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKV 225
           ALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKV
Sbjct: 181 ALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKV 225


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score =  320 bits (821), Expect = 7e-88
 Identities = 162/263 (61%), Positives = 209/263 (79%), Gaps = 3/263 (1%)

Query: 16  CARL--SVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNV 73
           CAR   SVRM+S+G+ R+  LAN+VA+VT ST GIGFAIARRLA+DGAHVV+SSRKQQNV
Sbjct: 10  CARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNV 69

Query: 74  DRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGT 133
           D+A+A LQGEGLSV G VCHVGKAEDRE+LVA A++  GG+D LV +A VNP  GS +  
Sbjct: 70  DQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDV 129

Query: 134 SEQIWDKILSVNVKSPALLLSQLLPYMENR-RGAVILVSSIAAYNPVVALGVYNVSKTAL 192
           +E++WDK L +NVK+PAL+   ++P ME R  G+V++VSSIAA++P      YNVSKTAL
Sbjct: 130 TEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTAL 189

Query: 193 LGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCA 252
           LGLT+TLA+ELAP++IRVNC+ PG+IKT FS++   ++   ++ KE  +++R+GE EDCA
Sbjct: 190 LGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCA 249

Query: 253 GIVSFLCSPDASYVNGENIAVAG 275
           GIVSFLCS DASY+ GE + V G
Sbjct: 250 GIVSFLCSEDASYITGETVVVGG 272


>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
           [Homo sapiens]
          Length = 281

 Score =  258 bits (660), Expect = 3e-69
 Identities = 139/267 (52%), Positives = 192/267 (71%), Gaps = 8/267 (2%)

Query: 16  CARL--SVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNV 73
           CAR   SVR++S+G+ R+  L N+VA+VT ST  IGFA+A+RLA+DGAHVV+S RKQQNV
Sbjct: 10  CARAGKSVRLASSGMTRRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNV 69

Query: 74  DRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVG----S 129
           D+A+A LQGEGLS+ G VCHVGK +D E+LVA A++  G +D L  S   N   G    +
Sbjct: 70  DQAVATLQGEGLSMTGTVCHVGKMKDWERLVATAMKLHGVIDILSLSI-TNSKRGLFWFT 128

Query: 130 TLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVI-LVSSIAAYNPVVALGVYNVS 188
            L T+E+ WD+ L +N K+ AL++  ++P ME R G  +  ++S+AA+ P+     YNVS
Sbjct: 129 LLQTAEEAWDRNLDINGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVS 188

Query: 189 KTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGES 248
           KTALLGL +TLA+ELAP++IRVNC+ PG+IKT FS++   ++   ++ KE  +++R+GE 
Sbjct: 189 KTALLGLNKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEP 248

Query: 249 EDCAGIVSFLCSPDASYVNGENIAVAG 275
           ED  GIVSFLCS DASY+ GE + V G
Sbjct: 249 EDSLGIVSFLCSEDASYLTGETVMVGG 275


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score =  244 bits (624), Expect = 5e-65
 Identities = 130/222 (58%), Positives = 165/222 (74%), Gaps = 6/222 (2%)

Query: 17  ARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRA 76
           AR SVRM+S+ + R+  L N+VA+VT ST GIGFAIARRLA+D AHVV+SSRKQQNVD+A
Sbjct: 13  ARKSVRMASSRMTRRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQA 72

Query: 77  MAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQ 136
           +A LQGEGLSV G VCHVGKAEDRE+LVA A++  GG+D LV +A VNP  GS +  +E+
Sbjct: 73  VATLQGEGLSVTGTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEE 132

Query: 137 IWDKILSVNVKSPALLLSQLLPYMENR-RGAVILVSSIAAYNPVVALGVYNVSKTALLGL 195
           +WDK L +NVK+PAL+   ++P ME R  G+V++VSSIAA++P      YNVSKTALLGL
Sbjct: 133 VWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGL 192

Query: 196 TRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFK 237
             TLA+ELAP++IRVNC     +  D S++     S W   K
Sbjct: 193 NNTLAIELAPRNIRVNC-----LHLDLSRLASAGCSGWTRKK 229


>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
          Length = 303

 Score =  110 bits (276), Expect = 1e-24
 Identities = 80/258 (31%), Positives = 135/258 (52%), Gaps = 22/258 (8%)

Query: 32  GVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQG-----EGLS 86
           G+L  +VA+VTG  +GIG AI + L   G++VVI+SRK + +  A  +LQ      +   
Sbjct: 14  GLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQAR 73

Query: 87  VAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQI----WDKIL 142
           V  I C++   E+   LV   L+  G ++FLV + G     G  L  +E I    W  +L
Sbjct: 74  VIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGG-----GQFLSPAEHISSKGWHAVL 128

Query: 143 SVNVKSPALLLSQLL-PYMENRRGAV--ILVSSIAAYNPVVALGVYNVSKTALLGLTRTL 199
             N+     +   +   +M+   G++  I+V + A +   V  G    ++  +  LT++L
Sbjct: 129 ETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSG---AARAGVYNLTKSL 185

Query: 200 ALELAPKDIRVNCVVPGIIKTDFSKVFHGN--ESLWKNFKEHHQLQRIGESEDCAGIVSF 257
           ALE A   IR+NCV PG+I +  +   +G+  +S ++   +    +RIG  E+ + +V F
Sbjct: 186 ALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCF 245

Query: 258 LCSPDASYVNGENIAVAG 275
           L SP AS++ G+++ V G
Sbjct: 246 LLSPAASFITGQSVDVDG 263


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score = 99.4 bits (246), Expect = 3e-21
 Identities = 74/241 (30%), Positives = 119/241 (49%), Gaps = 12/241 (4%)

Query: 36  NRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVG 95
           ++V  V G + GIG A+A+ +AR G  + + +R  +    A   L G+ L+ +   C V 
Sbjct: 2   DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFS---CDVA 58

Query: 96  KAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQ 155
           K  D +    +  +H G V+FLV +AG+N   G  + T  +     L  N+    L    
Sbjct: 59  KEHDVQNTFEELEKHLGRVNFLVNAAGINR-DGLLVRTKTEDMVSQLHTNLLGSMLTCKA 117

Query: 156 LLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVV 214
            +  M + + G+++ V SI          VY+ SK  L+G +R LA E+A K IRVN V 
Sbjct: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVA 177

Query: 215 PGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNGENIAVA 274
           PG + TD +K     +   ++ K++  L R GE+ + A  V FL   ++ Y+ G  + V 
Sbjct: 178 PGFVHTDMTK-----DLKEEHLKKNIPLGRFGETIEVAHAVVFLL--ESPYITGHVLVVD 230

Query: 275 G 275
           G
Sbjct: 231 G 231


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 73/245 (29%), Positives = 117/245 (47%), Gaps = 9/245 (3%)

Query: 35  ANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHV 94
           A +V VVTG   GIG  I R     GA VVI   K ++  RA   L+ E      I+C V
Sbjct: 8   AGKVVVVTGGGRGIGAGIVRAFVNSGARVVICD-KDESGGRA---LEQELPGAVFILCDV 63

Query: 95  GKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLS 154
            + +D + LV++ +   G +D +V +AG +P       TS Q + ++L +N+     L  
Sbjct: 64  TQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTK 123

Query: 155 QLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVV 214
             LPY+   +G VI +SS+           Y  +K A+  +T+ LAL+ +P  +RVNC+ 
Sbjct: 124 LALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCIS 183

Query: 215 PGIIKT----DFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNGEN 270
           PG I T    + + +     +  +       L R+G+  +      FL S +A++  G  
Sbjct: 184 PGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLAS-EANFCTGIE 242

Query: 271 IAVAG 275
           + V G
Sbjct: 243 LLVTG 247


>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score = 93.2 bits (230), Expect = 2e-19
 Identities = 74/251 (29%), Positives = 114/251 (45%), Gaps = 11/251 (4%)

Query: 34  LANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSV------ 87
           L + +A+VTG+ SGIG A++ RLA +GA V      +      +  L G G         
Sbjct: 9   LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGN 68

Query: 88  -AGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNV 146
            A     V +A     L+ +          +V S          L  SE  WDK+++VN+
Sbjct: 69  HAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNL 128

Query: 147 KSPALLLSQLLPYMENR--RGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELA 204
           K   L+       + +   RG++I +SSI      V    Y  SK  ++GLT+T A EL 
Sbjct: 129 KGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELG 188

Query: 205 PKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDAS 264
              IR N V+PG I T  ++     + +     E   +  +G+ ED A +V+FL S D+ 
Sbjct: 189 RHGIRCNSVLPGFIATPMTQKV--PQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSG 246

Query: 265 YVNGENIAVAG 275
           Y+ G ++ V G
Sbjct: 247 YITGTSVEVTG 257


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score = 88.2 bits (217), Expect = 7e-18
 Identities = 74/250 (29%), Positives = 125/250 (50%), Gaps = 16/250 (6%)

Query: 32  GVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIV 91
           G L  +V ++T +  GIG A A   AR+GA V+ +   +  +   + K  G    +   V
Sbjct: 2   GRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQE-LEKYPG----IQTRV 56

Query: 92  CHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPAL 151
             V K +  +Q  A  +E    +D L   AG     G+ L   E+ WD  +++NV+S  L
Sbjct: 57  LDVTKKKQIDQF-ANEVER---LDVLFNVAGFVHH-GTVLDCEEKDWDFSMNLNVRSMYL 111

Query: 152 LLSQLLPYM-ENRRGAVILVSSIAA-YNPVVALGVYNVSKTALLGLTRTLALELAPKDIR 209
           ++   LP M   + G +I +SS+A+    VV   VY+ +K A++GLT+++A +   + IR
Sbjct: 112 MIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIR 171

Query: 210 VNCVVPGIIKTDFSK---VFHGN-ESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASY 265
            NCV PG + T   +      GN E    +F +  +  R   +E+ A +  +L S +++Y
Sbjct: 172 CNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAY 231

Query: 266 VNGENIAVAG 275
           V G  + + G
Sbjct: 232 VTGNPVIIDG 241


>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
          Length = 244

 Score = 84.7 bits (208), Expect = 8e-17
 Identities = 74/245 (30%), Positives = 113/245 (46%), Gaps = 13/245 (5%)

Query: 34  LANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCH 93
           LA R  +VTG+  GIG    + L   GA VV  SR Q ++D  + +  G    +  +   
Sbjct: 5   LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCVD 60

Query: 94  VGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLL 153
           +G  E  E    +AL   G VD LV +A V  L+   L  +++ +D+   VN+++  + +
Sbjct: 61  LGDWEATE----RALGSVGPVDLLVNNAAV-ALLQPFLEVTKEAFDRSFEVNLRA-VIQV 114

Query: 154 SQLLPYMENRRG---AVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRV 210
           SQ++      RG   A++ VSS  +   V    VY  +K AL  LT+ +ALEL P  IRV
Sbjct: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174

Query: 211 NCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNGEN 270
           N V P ++ T   +    +    K       L +  E E     + FL S  +    G  
Sbjct: 175 NAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGST 234

Query: 271 IAVAG 275
           + V G
Sbjct: 235 LPVEG 239


>gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
          Length = 292

 Score = 84.0 bits (206), Expect = 1e-16
 Identities = 77/247 (31%), Positives = 112/247 (45%), Gaps = 6/247 (2%)

Query: 33  VLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQG-EGLSVAGIV 91
           +L ++VA +TG  SGIGF IA    R G H VI+SR    V  A  KL G  G     + 
Sbjct: 25  LLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLS 84

Query: 92  CHVGKAEDREQLVAKALEHCGGVDFLV-CSAGVNPLVGSTLGTSEQIWDKILSVNVKSPA 150
             V         V +AL+  G +D L+ C+AG        L  S   +  ++ ++     
Sbjct: 85  MDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGAL--SFNAFKTVMDIDTSGTF 142

Query: 151 LLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVY-NVSKTALLGLTRTLALELAPKDIR 209
            +   L        G VI+  +    N   AL V+   +K A+  +TR LA+E  P++IR
Sbjct: 143 NVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIR 202

Query: 210 VNCVVPGIIK-TDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNG 268
           VN + PG I  T+  +   G ++          LQR+G   + A  V +L SP ASYV G
Sbjct: 203 VNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTG 262

Query: 269 ENIAVAG 275
             +   G
Sbjct: 263 AVLVADG 269


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 82.4 bits (202), Expect = 4e-16
 Identities = 65/213 (30%), Positives = 98/213 (46%), Gaps = 19/213 (8%)

Query: 37  RVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKL--QGEGLSVAGIVCHV 94
           +VA+VTG+  GIG A A  L   GA V +     +   +  A L  Q E      I C V
Sbjct: 6   KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDV 65

Query: 95  GKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLS 154
              +       K ++H G +D LV +AGVN         +E+ W+K L +N+ S      
Sbjct: 66  ADQQQLRDTFRKVVDHFGRLDILVNNAGVN---------NEKNWEKTLQINLVSVISGTY 116

Query: 155 QLLPYMENRRGA----VILVSSIAAYNPVVALGVYNVSKTALLGLTRT--LALELAPKDI 208
             L YM  + G     +I +SS+A   PV    VY  SK  ++G TR+  LA  L    +
Sbjct: 117 LGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGV 176

Query: 209 RVNCVVPGIIKTDFSKVFHGNESL--WKNFKEH 239
           R+N + PG + T   +     E++  +  +K+H
Sbjct: 177 RLNAICPGFVNTAILESIEKEENMGQYIEYKDH 209


>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
          Length = 260

 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 69/260 (26%), Positives = 123/260 (47%), Gaps = 23/260 (8%)

Query: 23  MSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQG 82
           M+  G++R     +R+A+VTG++ GIG A+AR L + G  VV  +R   N++   A+ + 
Sbjct: 1   MARPGMER---WRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKS 57

Query: 83  EGL--SVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGV----NPLVGSTLGTSEQ 136
            G   ++    C +   ED   + +       GVD  + +AG+      L GST G    
Sbjct: 58  AGYPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSG---- 113

Query: 137 IWDKILSVNVKSPALLLSQLLPYMENRR---GAVILVSSIAAYN--PVVALGVYNVSKTA 191
            W  + +VNV + ++   +    M+ R    G +I ++S++ +   P+     Y+ +K A
Sbjct: 114 -WKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYA 172

Query: 192 LLGLTRTLALEL--APKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESE 249
           +  LT  L  EL  A   IR  C+ PG+++T F+   H  +   +     ++  +  + E
Sbjct: 173 VTALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDP--EKAAATYEQMKCLKPE 230

Query: 250 DCAGIVSFLCSPDASYVNGE 269
           D A  V ++ S  A    G+
Sbjct: 231 DVAEAVIYVLSTPAHIQIGD 250


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 64/197 (32%), Positives = 102/197 (51%), Gaps = 17/197 (8%)

Query: 35  ANRVAVVTGSTSGIGFAIARRLARDGA---HVVISSR---KQQNVDRAMAKLQGEGLSVA 88
           A R  +++G +SGIG  +A +LA D      VV + R   K++ ++ A  +  G+ L+VA
Sbjct: 4   APRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVA 63

Query: 89  GI-VCHVGKAEDREQLVAKALEHCGG-VDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNV 146
            + VC        ++ VA+ L    G VD LV +AG+  LVG   G S      +   N 
Sbjct: 64  QLDVCS-------DESVAQCLSCIQGEVDVLVNNAGMG-LVGPLEGLSLAAMQNVFDTNF 115

Query: 147 KSPALLLSQLLPYMENRR-GAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAP 205
                L+  +LP M+ RR G ++++SS+     V+   VY  SK AL G   +LA++L  
Sbjct: 116 FGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQ 175

Query: 206 KDIRVNCVVPGIIKTDF 222
            +I ++ V PG + T+F
Sbjct: 176 FNIFISLVEPGPVVTEF 192


>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 57/198 (28%), Positives = 101/198 (51%), Gaps = 10/198 (5%)

Query: 30  RKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAG 89
           R  +L  +  +VTG++ GIG  +A  LA+ GAHVV+++R ++ + + ++     G + A 
Sbjct: 28  RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAH 87

Query: 90  IVCHVGKAED---REQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNV 146
            +   G  ED    EQ VA+A +  GG+D L+ +   N  +         +  K + VN 
Sbjct: 88  YI--AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHV-RKSMEVNF 144

Query: 147 KSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPK 206
            S  +L    LP ++   G++++VSS+A       +  Y+ SK AL G   ++  E +  
Sbjct: 145 LSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVS 204

Query: 207 DIRVN---CVVPGIIKTD 221
            + V+   CV+ G+I T+
Sbjct: 205 RVNVSITLCVL-GLIDTE 221


>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 57/198 (28%), Positives = 101/198 (51%), Gaps = 10/198 (5%)

Query: 30  RKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAG 89
           R  +L  +  +VTG++ GIG  +A  LA+ GAHVV+++R ++ + + ++     G + A 
Sbjct: 28  RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAH 87

Query: 90  IVCHVGKAED---REQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNV 146
            +   G  ED    EQ VA+A +  GG+D L+ +   N  +         +  K + VN 
Sbjct: 88  YI--AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHV-RKSMEVNF 144

Query: 147 KSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPK 206
            S  +L    LP ++   G++++VSS+A       +  Y+ SK AL G   ++  E +  
Sbjct: 145 LSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVS 204

Query: 207 DIRVN---CVVPGIIKTD 221
            + V+   CV+ G+I T+
Sbjct: 205 RVNVSITLCVL-GLIDTE 221


>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
           sapiens]
          Length = 330

 Score = 72.4 bits (176), Expect = 4e-13
 Identities = 74/253 (29%), Positives = 125/253 (49%), Gaps = 22/253 (8%)

Query: 37  RVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGK 96
           R AVV+G+T GIG A A  LA  G ++++ SR ++ + + +AK   +   V   +     
Sbjct: 68  RWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKL-QVVAKDIADTYKVETDIIVADF 126

Query: 97  AEDREQL--VAKALEHCGGVDFLVCSAGV---NPLVGSTLGTSEQIWDKILSVNVKSPAL 151
           +  RE    + +AL+    V  LV + GV    P   + L + +++WD I++VN+ + +L
Sbjct: 127 SSGREIYLPIREALKD-KDVGILVNNVGVFYPYPQYFTQL-SEDKLWD-IINVNIAAASL 183

Query: 152 LLSQLLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRV 210
           ++  +LP M E ++GA++ +SS +   P   L  ++ SK  L   +R L  E A K I V
Sbjct: 184 MVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFV 243

Query: 211 NCVVPGIIKTDF---SKVFHGNESLWKNFK--EHHQLQRIGESEDCAGI----VSFLCS- 260
             ++P  + T     S   H    L  + K   HH +  +G S+   G     + FL + 
Sbjct: 244 QSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFAQ 303

Query: 261 --PDASYVNGENI 271
             P+  +V G NI
Sbjct: 304 YMPEWLWVWGANI 316


>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
           [Homo sapiens]
          Length = 261

 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 59/197 (29%), Positives = 88/197 (44%), Gaps = 19/197 (9%)

Query: 38  VAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKA 97
           VAV+TG  SG+G A A RL   GA  V+        +    KL   G +       V   
Sbjct: 12  VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL---GNNCVFAPADVTSE 68

Query: 98  EDREQLVAKALEHCGGVDFLVCSAGV-------NPLVGSTLGTSEQIWDKILSVN----- 145
           +D +  +A A    G VD  V  AG+       N   G T    +  + ++L VN     
Sbjct: 69  KDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLED--FQRVLDVNLMGTF 126

Query: 146 --VKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALEL 203
             ++  A  + Q  P    +RG +I  +S+AA+   V    Y+ SK  ++G+T  +A +L
Sbjct: 127 NVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDL 186

Query: 204 APKDIRVNCVVPGIIKT 220
           AP  IRV  + PG+  T
Sbjct: 187 APIGIRVMTIAPGLFGT 203


>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
           sapiens]
          Length = 315

 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 51/175 (29%), Positives = 91/175 (52%), Gaps = 8/175 (4%)

Query: 40  VVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGL-SVAGIVCHVGKAE 98
           ++TG+ +G+G  +A   AR G+H+V+++  +  + + +   +  G   V  I   +   E
Sbjct: 33  LLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASPE 92

Query: 99  DREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGT---SEQIWDKILSVNVKSPALLLSQ 155
             E +V  AL+  GG+D+LV    +N + G+  GT   S Q    ++ VN  S   L S+
Sbjct: 93  APESVVQFALDKLGGLDYLV----LNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSR 148

Query: 156 LLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRV 210
            LP + + +G++++VSS+    P      Y+ +K AL G   +L  EL  +D+ V
Sbjct: 149 ALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNV 203


>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
           sapiens]
          Length = 286

 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 51/175 (29%), Positives = 91/175 (52%), Gaps = 8/175 (4%)

Query: 40  VVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGL-SVAGIVCHVGKAE 98
           ++TG+ +G+G  +A   AR G+H+V+++  +  + + +   +  G   V  I   +   E
Sbjct: 33  LLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASPE 92

Query: 99  DREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGT---SEQIWDKILSVNVKSPALLLSQ 155
             E +V  AL+  GG+D+LV    +N + G+  GT   S Q    ++ VN  S   L S+
Sbjct: 93  APESVVQFALDKLGGLDYLV----LNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSR 148

Query: 156 LLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRV 210
            LP + + +G++++VSS+    P      Y+ +K AL G   +L  EL  +D+ V
Sbjct: 149 ALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNV 203


>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
           [Homo sapiens]
          Length = 178

 Score = 69.3 bits (168), Expect = 3e-12
 Identities = 55/170 (32%), Positives = 78/170 (45%), Gaps = 15/170 (8%)

Query: 37  RVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKL--QGEGLSVAGIVCHV 94
           +VA+VTG+  GIG A A  L   GA V +     +   +  A L  Q E      I C V
Sbjct: 6   KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDV 65

Query: 95  GKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLS 154
              +       K ++H G +D LV +AGVN         +E+ W+K L +N+ S      
Sbjct: 66  ADQQQLRDTFRKVVDHFGRLDILVNNAGVN---------NEKNWEKTLQINLVSVISGTY 116

Query: 155 QLLPYMENRRGA----VILVSSIAAYNPVVALGVYNVSKTALLGLTRTLA 200
             L YM  + G     +I +SS+A   PV    VY  SK  ++G TR+ A
Sbjct: 117 LGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA 166


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 56/199 (28%), Positives = 84/199 (42%), Gaps = 5/199 (2%)

Query: 30  RKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAG 89
           R+  +   + ++TG+  GIG   A   A+  + +V+    +  ++   AK +G G  V  
Sbjct: 30  RRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHT 89

Query: 90  IVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSP 149
            V      ED      K     G V  LV +AGV         T +   +K   VNV + 
Sbjct: 90  FVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGV-VYTSDLFATQDPQIEKTFEVNVLAH 148

Query: 150 ALLLSQLLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDI 208
                  LP M +N  G ++ V+S A +  V  L  Y  SK A +G  +TL  ELA   I
Sbjct: 149 FWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQI 208

Query: 209 ---RVNCVVPGIIKTDFSK 224
              +  C+ P  + T F K
Sbjct: 209 TGVKTTCLCPNFVNTGFIK 227


>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
           sapiens]
          Length = 328

 Score = 67.4 bits (163), Expect = 1e-11
 Identities = 66/206 (32%), Positives = 95/206 (46%), Gaps = 16/206 (7%)

Query: 34  LANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVA-GIVC 92
           +A  V ++TG +SGIG  +A RLA D +     S K     R + K QG     A  + C
Sbjct: 1   MARTVVLITGCSSGIGLHLAVRLASDPS----QSFKVYATLRDL-KTQGRLWEAARALAC 55

Query: 93  HVGKAEDRE------QLVAKALEHC--GGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSV 144
             G  E  +      + VA A E    G VD LVC+AG+  L+G      E     +L V
Sbjct: 56  PPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLG-LLGPLEALGEDAVASVLDV 114

Query: 145 NVKSPALLLSQLLPYMENR-RGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALEL 203
           NV     +L   LP M+ R  G V++  S+     +    VY  SK AL GL  +LA+ L
Sbjct: 115 NVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLL 174

Query: 204 APKDIRVNCVVPGIIKTDFSKVFHGN 229
            P  + ++ +  G + T F +   G+
Sbjct: 175 LPFGVHLSLIECGPVHTAFMEKVLGS 200


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 67.4 bits (163), Expect = 1e-11
 Identities = 60/209 (28%), Positives = 90/209 (43%), Gaps = 26/209 (12%)

Query: 31  KGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGI 90
           K  L N V V+TG+TSG+G   A+     GA +V+  R    ++  + +L          
Sbjct: 47  KAYLRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTAS------- 99

Query: 91  VCHVGKAE------------DREQLVAKALE--HCGG-VDFLVCSAGVNPLVGSTLGTSE 135
             H  K +            D   +VA A E   C G VD LV +AG++   G+ + T+ 
Sbjct: 100 --HATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGIS-YRGTIMDTTV 156

Query: 136 QIWDKILSVNVKSPALLLSQLLPYMENRR-GAVILVSSIAAYNPVVALGVYNVSKTALLG 194
            +  +++  N   P  L   LLP M  RR G ++ +SSI     +     Y  SK A   
Sbjct: 157 DVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQA 216

Query: 195 LTRTLALELAPKDIRVNCVVPGIIKTDFS 223
               L  E+   +I V  + PG I T+ S
Sbjct: 217 FFDCLRAEMEQYEIEVTVISPGYIHTNLS 245


>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
          Length = 335

 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 64/246 (26%), Positives = 111/246 (45%), Gaps = 11/246 (4%)

Query: 37  RVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGE-GLSVAGIVCHVG 95
           +VA +TG  +G+G  +   L+  GA  VI+SRK   +     ++  + G  V  I C V 
Sbjct: 60  KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119

Query: 96  KAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQ 155
             +  +  V++ ++  G  + ++ +A  N  +  T   S   W  I  + +   A +  +
Sbjct: 120 DPDMVQNTVSELIKVAGHPNIVINNAAGN-FISPTERLSPNAWKTITDIVLNGTAFVTLE 178

Query: 156 L-LPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLG---LTRTLALELAPKDIRVN 211
           +    ++ ++GA  L  SI         G    S +A  G   ++++LA E     +R N
Sbjct: 179 IGKQLIKAQKGAAFL--SITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFN 236

Query: 212 CVVPGIIKTD--FSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNGE 269
            + PG IKT   FS++     +  K         R+G  E+ A + +FLCS  AS++NG 
Sbjct: 237 VIQPGPIKTKGAFSRL-DPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGA 295

Query: 270 NIAVAG 275
            I   G
Sbjct: 296 VIKFDG 301


>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
          Length = 312

 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 55/193 (28%), Positives = 97/193 (50%), Gaps = 9/193 (4%)

Query: 39  AVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAE 98
           AVVTGST GIG + A  LA+ G  VV+ SR +  +D+  ++++ E   V      V  A 
Sbjct: 53  AVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIK-EKFKVETRTIAVDFAS 111

Query: 99  DREQLVAKALEHCGGVD--FLVCSAGVN---PLVGSTLGTSEQIWDKILSVNVKSPALLL 153
             E +  K      G++   LV + G++   P     +   + +  K++++N+ S   + 
Sbjct: 112 --EDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMT 169

Query: 154 SQLLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNC 212
             +LP M E  +GA++ +SS +   PV  L +Y+ +KT +   ++ L  E   K + V  
Sbjct: 170 QLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQS 229

Query: 213 VVPGIIKTDFSKV 225
           V+P  + T  +K+
Sbjct: 230 VLPYFVATKLAKI 242


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 48/182 (26%), Positives = 88/182 (48%), Gaps = 7/182 (3%)

Query: 40  VVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIV--CHVGKA 97
           VVTG +SGIG  IA    + GA + + +R +  + +A  +++   ++   +V    V  +
Sbjct: 36  VVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVS 95

Query: 98  EDR---EQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLS 154
           +D    E ++ +A E  G VD LV  AG+  + G         +++++S+N         
Sbjct: 96  QDYNQVENVIKQAQEKLGPVDMLVNCAGM-AVSGKFEDLEVSTFERLMSINYLGSVYPSR 154

Query: 155 QLLPYMENRR-GAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCV 213
            ++  M+ RR G ++ VSS A    +     Y+ SK A+ GL   L +E+ P ++ +   
Sbjct: 155 AVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVA 214

Query: 214 VP 215
            P
Sbjct: 215 YP 216


>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
          Length = 418

 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 47/156 (30%), Positives = 78/156 (50%), Gaps = 9/156 (5%)

Query: 32  GVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQ-------NVDRAMAKLQGEG 84
           G LA     +TG++ GIG AIA + A+DGA++VI+++  Q        +  A  +++  G
Sbjct: 6   GRLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEAVG 65

Query: 85  LSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSV 144
                 +  V   +     V KA++  GG+D LV +A    L  +TL T  +  D +++V
Sbjct: 66  GKALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLT-NTLDTPTKRLDLMMNV 124

Query: 145 NVKSPALLLSQLLPYMENRRGAVIL-VSSIAAYNPV 179
           N +   L     +PY++  + A IL +S     NPV
Sbjct: 125 NTRGTYLASKACIPYLKKSKVAHILNISPPLNLNPV 160


>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
           sapiens]
          Length = 311

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 59/218 (27%), Positives = 96/218 (44%), Gaps = 17/218 (7%)

Query: 31  KGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAG- 89
           K  + N+V V+T + SG+G   AR     GA +V+  +  + ++     L    +SVA  
Sbjct: 32  KSAVQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDAL----ISVADP 87

Query: 90  --------IVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKI 141
                   ++  +        +  + L+  G VD L+ +A V  + G     S ++  KI
Sbjct: 88  SKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVK-VKGPAHKISLELDKKI 146

Query: 142 LSVNVKSPALLLSQLLPYMENRR-GAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLA 200
           +  N   P  L   LLP M +RR G ++LV++I     +     Y  SK A LG    L 
Sbjct: 147 MDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLR 206

Query: 201 LELAPKDIRVNCVVPGIIKTDFSKVFHGN--ESLWKNF 236
            E+   D+ ++ V P  I++       GN   S+WK F
Sbjct: 207 AEVEEYDVVISTVSPTFIRSYHVYPEQGNWEASIWKFF 244


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,327,936
Number of Sequences: 37866
Number of extensions: 365425
Number of successful extensions: 844
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 714
Number of HSP's gapped (non-prelim): 76
length of query: 280
length of database: 18,247,518
effective HSP length: 101
effective length of query: 179
effective length of database: 14,423,052
effective search space: 2581726308
effective search space used: 2581726308
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.