Guide to the Human Genome
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Search of human proteins with 49472841

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|49472841 A kinase (PRKA) anchor protein 8-like [Homo
sapiens]
         (646 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|49472841 A kinase (PRKA) anchor protein 8-like [Homo sapiens]     1335   0.0  
gi|5031579 A-kinase anchor protein 8 [Homo sapiens]                   299   6e-81
gi|33946297 zinc finger protein 326 isoform 1 [Homo sapiens]          172   9e-43
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]              52   1e-06
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]             52   1e-06
gi|13540523 nucleosomal binding protein 1 [Homo sapiens]               50   5e-06
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    49   1e-05
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]      49   2e-05
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]                     48   2e-05
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]                     48   2e-05
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]      48   3e-05
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]      48   3e-05
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]       48   3e-05
gi|60498973 myelin transcription factor 1-like [Homo sapiens]          47   4e-05
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    47   5e-05
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...    47   5e-05
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]     46   1e-04
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...    46   1e-04
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    45   2e-04
gi|158420731 chromodomain helicase DNA binding protein 3 isoform...    45   2e-04
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...    45   2e-04
gi|4507353 TBP-associated factor 15 isoform 2 [Homo sapiens]           44   4e-04
gi|21327701 TBP-associated factor 15 isoform 1 [Homo sapiens]          44   4e-04
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    44   4e-04
gi|83716024 kinesin family member 21B [Homo sapiens]                   44   4e-04
gi|23503317 coiled-coil domain containing 96 [Homo sapiens]            44   4e-04
gi|39812378 RAN binding protein 9 [Homo sapiens]                       44   5e-04
gi|21361639 DIPB protein [Homo sapiens]                                44   5e-04
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1...    44   5e-04
gi|7706687 Enah/Vasp-like [Homo sapiens]                               44   5e-04

>gi|49472841 A kinase (PRKA) anchor protein 8-like [Homo sapiens]
          Length = 646

 Score = 1335 bits (3454), Expect = 0.0
 Identities = 646/646 (100%), Positives = 646/646 (100%)

Query: 1   MSYTGFVQGSETTLQSTYSDTSAQPTCDYGYGTWNSGTNRGYEGYGYGYGYGQDNTTNYG 60
           MSYTGFVQGSETTLQSTYSDTSAQPTCDYGYGTWNSGTNRGYEGYGYGYGYGQDNTTNYG
Sbjct: 1   MSYTGFVQGSETTLQSTYSDTSAQPTCDYGYGTWNSGTNRGYEGYGYGYGYGQDNTTNYG 60

Query: 61  YGMATSHSWEMPSSDTNANTSASGSASADSVLSRINQRLDMVPHLETDMMQGGVYGSGGE 120
           YGMATSHSWEMPSSDTNANTSASGSASADSVLSRINQRLDMVPHLETDMMQGGVYGSGGE
Sbjct: 61  YGMATSHSWEMPSSDTNANTSASGSASADSVLSRINQRLDMVPHLETDMMQGGVYGSGGE 120

Query: 121 RYDSYESCDSRAVLSERDLYRSGYDYSELDPEMEMAYEGQYDAYRDQFRMRGNDTFGPRA 180
           RYDSYESCDSRAVLSERDLYRSGYDYSELDPEMEMAYEGQYDAYRDQFRMRGNDTFGPRA
Sbjct: 121 RYDSYESCDSRAVLSERDLYRSGYDYSELDPEMEMAYEGQYDAYRDQFRMRGNDTFGPRA 180

Query: 181 QGWARDARSGRPMASGYGRMWEDPMGARGQCMSGASRLPSLFSQNIIPEYGMFQGMRGGG 240
           QGWARDARSGRPMASGYGRMWEDPMGARGQCMSGASRLPSLFSQNIIPEYGMFQGMRGGG
Sbjct: 181 QGWARDARSGRPMASGYGRMWEDPMGARGQCMSGASRLPSLFSQNIIPEYGMFQGMRGGG 240

Query: 241 AFPGGSRFGFGFGNGMKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNS 300
           AFPGGSRFGFGFGNGMKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNS
Sbjct: 241 AFPGGSRFGFGFGNGMKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNS 300

Query: 301 DSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQ 360
           DSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQ
Sbjct: 301 DSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQ 360

Query: 361 TKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYV 420
           TKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYV
Sbjct: 361 TKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYV 420

Query: 421 GTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVE 480
           GTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVE
Sbjct: 421 GTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVE 480

Query: 481 AAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLE 540
           AAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLE
Sbjct: 481 AAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLE 540

Query: 541 RYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAV 600
           RYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAV
Sbjct: 541 RYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAV 600

Query: 601 SPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP 646
           SPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP
Sbjct: 601 SPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP 646


>gi|5031579 A-kinase anchor protein 8 [Homo sapiens]
          Length = 692

 Score =  299 bits (765), Expect = 6e-81
 Identities = 238/693 (34%), Positives = 341/693 (49%), Gaps = 126/693 (18%)

Query: 30  GYGTWNSGTN-------------RGYEGYGYGYGYGQDNTT-----NYGYGMATSHSWEM 71
           GYG W++G               +GYE Y Y   YG  NT+      Y YG A   SWE 
Sbjct: 7   GYGAWSAGPANTQGAYGTGVASWQGYENYNY---YGAQNTSVTTGATYSYGPA---SWEA 60

Query: 72  PSSDTN---ANTSASGSAS---------ADSVLSRINQRLDMVPHLETDMMQGGVYGSGG 119
             ++     A   A   AS         +DS++++INQRLDM+        +GG  GSGG
Sbjct: 61  AKANDGGLAAGAPAMHMASYGPEPCTDNSDSLIAKINQRLDMMSK------EGGRGGSGG 114

Query: 120 E-----------RYDSYESCDSRAVLSERDLYRSGYDYS---ELDPEMEMAYEGQYDAYR 165
                       R+  +ES DSR  L E + YR  Y Y    +L  +   ++ GQY   R
Sbjct: 115 GGEGIQDRESSFRFQPFESYDSRPCLPEHNPYRPSYSYDYEFDLGSDRNGSFGGQYSECR 174

Query: 166 DQFRMRGN-DTF-GPRAQGWARD----------------ARSGRPMASGYGRMWEDPMGA 207
           D  R RG+ D F   R QG  +D                A S  P+++ +  +  + +G 
Sbjct: 175 DPARERGSLDGFMRGRGQGRFQDRSNPGTFMRSDPFVPPAASSEPLSTPWNEL--NYVGG 232

Query: 208 RGQCMSGASRLP-SLFSQNIIPEYGMFQGMRGGGAFPGGSRFGFGFGNGMKQMRRTWKTW 266
           RG      SR P SLFSQ++ P+YG+  GM+G G +   S   +G G    +MR   +  
Sbjct: 233 RGLGGPSPSRPPPSLFSQSMAPDYGVM-GMQGAGGYD--STMPYGCGRSQPRMRDRDRPK 289

Query: 267 TTADFRTKK----KKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAV 322
                R       +KRKQ    +EPD+K  R D S+   S+ND+   G+   G E     
Sbjct: 290 RRGFDRFGPDGTGRKRKQFQLYEEPDTKLARVD-SEGDFSENDDAA-GDFRSGDE----- 342

Query: 323 EKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDR 382
                  GEDE   + GR+ G+++ E       DE+ + +R+ Q       +++ R RDR
Sbjct: 343 ----EFKGEDELC-DSGRQRGEKEDE-------DEDVKKRREKQ-------RRRDRTRDR 383

Query: 383 MVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKK 442
             +RIQF CS+CK+R+F ++E+  HL SKFHKE  +++ TKLP +T +FLQEY+ N+ KK
Sbjct: 384 AADRIQFACSVCKFRSFDDEEIQKHLQSKFHKETLRFISTKLPDKTVEFLQEYIVNRNKK 443

Query: 443 TEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHL 502
            E+ R+ + + +    +     D  + I  EHF KK+EAAHC ACD+ IP Q  ++Q+HL
Sbjct: 444 IEKRRQELMEKETAKPK----PDPFKGIGQEHFFKKIEAAHCLACDMLIPAQPQLLQRHL 499

Query: 503 KTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFT-DSPEEEKEQEE 561
            ++DHN NRRL  EQ KK+SL VA+S+LNN+ I K LE+YLKGE+PFT ++ + E E ++
Sbjct: 500 HSVDHNHNRRLAAEQFKKTSLHVAKSVLNNRHIVKMLEKYLKGEDPFTSETVDPEMEGDD 559

Query: 562 AEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPP----PPEEEEEGAVP 617
             GG   +    E A          A   V  E AP   S   P     P +  E G+ P
Sbjct: 560 NLGGEDKKETPEEVAADVLAEVITAAVRAVDGEGAPAPESSGEPAEDEGPTDTAEAGSDP 619

Query: 618 LLGGALQRQI-------RGIPGLDVEDDEEGGG 643
                L+ Q+       +G+P    E  E G G
Sbjct: 620 QAEQLLEEQVPCGTAHEKGVPKARSEAAEAGNG 652


>gi|33946297 zinc finger protein 326 isoform 1 [Homo sapiens]
          Length = 582

 Score =  172 bits (436), Expect = 9e-43
 Identities = 164/602 (27%), Positives = 253/602 (42%), Gaps = 144/602 (23%)

Query: 38  TNRGYEGYGYGYGYGQDNTTNYGYGMATSHSWEMPSSDTNANTSASGSASADSVLSRINQ 97
           T +G+ G    YG G     +  YG                + S  G  S DS L   NQ
Sbjct: 15  TYQGFNGMDRDYGPGSYGGMDRDYG----------------HGSYGGQRSMDSYL---NQ 55

Query: 98  RLDMVPHLETDMMQGGVYGSGGERYDSYESCDSRAVLSERDLYRSGYDYSELDPEMEMAY 157
              M  H           G GG R+  YES DSR+ L  RDLYRSGY ++E  PE +  +
Sbjct: 56  SYGMDNHSG---------GGGGSRFGPYESYDSRSSLGGRDLYRSGYGFNE--PE-QSRF 103

Query: 158 EGQYDAYRDQFRMRGNDTFGPRAQG---W-ARDARS----------GRPMASGYG----- 198
            G Y    +       D+FG R QG   W A  +RS          GR   S Y      
Sbjct: 104 GGSYGGRFESSYRNSLDSFGGRNQGGSSWEAPYSRSKLRPGFMEDRGRENYSSYSSFSSP 163

Query: 199 RMWEDPMGARGQCMSGASRLP-SLFSQNIIPEYGMFQGMRGGGAFPGGSRFGFGFGNG-M 256
            M   P+G+RG+   G    P S F            G R   AF GG   G G G G M
Sbjct: 164 HMKPAPVGSRGR---GTPAYPESTF------------GSRNYDAF-GGPSTGRGRGRGHM 207

Query: 257 KQMRRTWKTWTTADFRTKKK----------KRKQGGSPDEPDSKATRTDCSDNSDSDNDE 306
                  +     D++ K            KRK     ++P     +             
Sbjct: 208 GDFGSIHRPGIVVDYQNKSTNVTVAAARGIKRKMMQPFNKPSGTFIK------------- 254

Query: 307 GTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQ 366
             + +  + +E     +  ++ D ++EE                         + KR+++
Sbjct: 255 --KPKLAKPMEKISLSKSPTKTDPKNEE-------------------------EEKRRIE 287

Query: 367 AGKKSQDKQKKRQRDRMVE--RIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYV--GT 422
           A ++ Q +++++  ++  +  R+ F CS CK+RTF E ++  HL+S  H+E   ++   T
Sbjct: 288 ARREKQRRRREKNSEKYGDGYRMAFTCSFCKFRTFEEKDIELHLESSSHQETLDHIQKQT 347

Query: 423 KLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVEAA 482
           K  K   +FL E + NK KKT   ++   +   ++  I  ++D+ + + ++  + KVE  
Sbjct: 348 KFDKVVMEFLHECMVNKFKKTSIRKQQTNNQTEVVKII--EKDVMEGVTVDDHMMKVETV 405

Query: 483 HCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERY 542
           HC+AC ++IP     +Q+HLK+ DH + ++   EQ K+ S++ A SILNN ++  + ER+
Sbjct: 406 HCSACSVYIPALHSSVQQHLKSPDHIKGKQAYKEQIKRESVLTATSILNNPIVKARYERF 465

Query: 543 LKGENPF--------------------TDSPEEEKEQEEAEGGALDEGAQGEAAGISEGA 582
           +KGENPF                     D P EE+E E+ E  A + G   E   + E  
Sbjct: 466 VKGENPFEIQDHSQDQQIEGDEEDEEKIDEPIEEEEDEDEEEEAEEVGEVEEVEEVEEVR 525

Query: 583 EG 584
           EG
Sbjct: 526 EG 527


>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
          Length = 849

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 49/208 (23%), Positives = 81/208 (38%), Gaps = 32/208 (15%)

Query: 432 LQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAME-----HFVKKVEAAHCAA 486
           L+ +  +K +   EL   +ED+   + + Y   ++      E     +F+  ++      
Sbjct: 126 LKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIR 185

Query: 487 CDLFIPMQFG----------IIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLIS 536
            D FI  Q+           ++ +     D    +RL ++ ++   + + ++ L  +   
Sbjct: 186 NDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLE-EFEE 244

Query: 537 KKLERYLKGENPFTDSPEEEKEQEEAEG----------------GALDEGAQGEAAGISE 580
           K  E Y K E  FTD  E + E ++ E                 GAL            E
Sbjct: 245 KASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKE 304

Query: 581 GAEGVPAQPPVPPEPAPGAVSPPPPPPP 608
           G  G  A PP PP P+ G V PPPPPPP
Sbjct: 305 GGTGHSALPPPPPLPSGGGVPPPPPPPP 332


>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
          Length = 1193

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 49/208 (23%), Positives = 81/208 (38%), Gaps = 32/208 (15%)

Query: 432 LQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAME-----HFVKKVEAAHCAA 486
           L+ +  +K +   EL   +ED+   + + Y   ++      E     +F+  ++      
Sbjct: 389 LKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIR 448

Query: 487 CDLFIPMQFG----------IIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLIS 536
            D FI  Q+           ++ +     D    +RL ++ ++   + + ++ L  +   
Sbjct: 449 NDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLE-EFEE 507

Query: 537 KKLERYLKGENPFTDSPEEEKEQEEAEG----------------GALDEGAQGEAAGISE 580
           K  E Y K E  FTD  E + E ++ E                 GAL            E
Sbjct: 508 KASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKE 567

Query: 581 GAEGVPAQPPVPPEPAPGAVSPPPPPPP 608
           G  G  A PP PP P+ G V PPPPPPP
Sbjct: 568 GGTGHSALPPPPPLPSGGGVPPPPPPPP 595


>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
          Length = 282

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 34/116 (29%), Positives = 59/116 (50%), Gaps = 7/116 (6%)

Query: 277 KRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGK 336
           K K+ G   E D K    D  +  + + +E    E  +G E  +  EKG + +G+D + K
Sbjct: 171 KEKEDGKKGE-DGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVK 229

Query: 337 ED--GREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFV 390
           ED   RE+GKED E G    ++E G+ K  L+  ++ +++ + ++ D   E  Q +
Sbjct: 230 EDEKEREDGKED-EGG---NEEEAGKEKEDLKEEEEGKEEDEIKEDDGKKEEPQSI 281



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 27/85 (31%), Positives = 45/85 (52%), Gaps = 5/85 (5%)

Query: 298 DNSDSDNDEGTEGEATEGLEGTE--AVEKGSRVDGEDEEGKEDGR--EEGKEDPEKGALT 353
           D  D + ++G  G+  +  +G E    +K     GED + KEDG+  E+GK + E G   
Sbjct: 133 DEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEK 192

Query: 354 TQDENGQTKRKLQA-GKKSQDKQKK 377
            +DE  +  RK    GK+++D ++K
Sbjct: 193 GEDEKEEEDRKETGDGKENEDGKEK 217



 Score = 36.6 bits (83), Expect = 0.074
 Identities = 33/117 (28%), Positives = 59/117 (50%), Gaps = 15/117 (12%)

Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLE-GTEAVEKGSRV---D 329
           K +K ++ G  D+  ++    D  +  D    E  +G   +G E G +  E+  R    D
Sbjct: 149 KDEKGEEDGKEDKNGNEKGE-DAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGD 207

Query: 330 G-EDEEGKEDG-REEG-----KEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQ 379
           G E+E+GKE G ++EG     KED ++     +DE G  +   +AGK+ +D +++ +
Sbjct: 208 GKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEE---EAGKEKEDLKEEEE 261



 Score = 35.0 bits (79), Expect = 0.21
 Identities = 29/118 (24%), Positives = 56/118 (47%), Gaps = 20/118 (16%)

Query: 270 DFRTKKKKRKQGGSPD-----EPDSKATRTDCSDNSDS-DNDEGTEGEATEGLEGTEAVE 323
           D   + +++ + G  D     E D K  +       D+ + ++G +GE  +G  G +  E
Sbjct: 133 DEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKG-NGEDGKE 191

Query: 324 KGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRD 381
           KG     EDE+ +ED +E G           ++E+G+ K   + GK  + K+ +++R+
Sbjct: 192 KG-----EDEKEEEDRKETGD--------GKENEDGKEKGDKKEGKDVKVKEDEKERE 236



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 38/119 (31%), Positives = 54/119 (45%), Gaps = 24/119 (20%)

Query: 288 DSKATRTDCSDNSDSDNDEGTEGEATE-GLEGTEAV-------EKGSRVDGED------E 333
           ++K T    S+    +  E    +ATE G E  EAV       E+  + D ED      E
Sbjct: 84  EAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGE 143

Query: 334 EGKED----GREEGKEDP---EKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVE 385
            GKED    G E+GKED    EKG    + E+G   +K + GK + +  K++  D   E
Sbjct: 144 AGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDG---KKGEDGKGNGEDGKEKGEDEKEE 199



 Score = 30.4 bits (67), Expect = 5.3
 Identities = 20/81 (24%), Positives = 38/81 (46%), Gaps = 6/81 (7%)

Query: 268 TADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSR 327
           T D +  +  +++G   +  D K    +       +++ G E EA +  E  +  E+G  
Sbjct: 205 TGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKE 264

Query: 328 VDGEDEEGKEDGREEGKEDPE 348
              EDE  ++DG+   KE+P+
Sbjct: 265 ---EDEIKEDDGK---KEEPQ 279


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 84/376 (22%), Positives = 148/376 (39%), Gaps = 70/376 (18%)

Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDN-DEGTEG-EATEGLEGTEAVEKGSRVDGE 331
           K  K+  G   DE +SK  +     NS  ++ DE  E  ++ +G +  +  + G  ++  
Sbjct: 156 KSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESG 215

Query: 332 DEE--------------GKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKK 377
           +E+               ++  RE  K D EK  L    E    K +L+ GKK Q KQK+
Sbjct: 216 NEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKE----KEELETGKKDQSKQKE 271

Query: 378 RQRDRMVERIQFVCSL-----------CKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPK 426
            QR    E ++   ++            +  T  ED+   +   K  K+  K  G K  K
Sbjct: 272 SQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDD---NEGDKKKKDKKKKKGEKEEK 328

Query: 427 QTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVEAAHCAA 486
           +           K KK    + TV+ +   + ++ ++++  Q+   E  +K++E      
Sbjct: 329 E-----------KEKKKGPSKATVKAMQEALAKL-KEEEERQKREEEERIKRLEELEAKR 376

Query: 487 CDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSIL--NNKLISKKLERYLK 544
                       ++  +     R R+   E+ +K  L     +L  + +    + E  LK
Sbjct: 377 ------------KEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLK 424

Query: 545 ------GENPFTDS-PEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAP 597
                  E P  DS P++    E+ +   + +  Q E+  +SE  E + A   V  +  P
Sbjct: 425 LLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQ--QLESKEVSESME-LCAAVEVMEQGVP 481

Query: 598 GAVSPPPPPPPEEEEE 613
                PPP  PEEEE+
Sbjct: 482 EKEETPPPVEPEEEED 497



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 74/353 (20%), Positives = 140/353 (39%), Gaps = 40/353 (11%)

Query: 272 RTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDN---DEGTEGEATEGLEGTEAVEKGSRV 328
           + K+K+  + G  D+   K ++    + +       D G    + E  E   A E     
Sbjct: 252 KLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAE----- 306

Query: 329 DGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGK------KSQDKQKKRQRDR 382
             +D EG +  +++ K+  EK     + + G +K  ++A +      K +++++KR+ + 
Sbjct: 307 --DDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEE 364

Query: 383 MVERIQFVCSLCKYRTFYEDEMASHLDSKF--HKEHFKYVGTKLPKQTADF-LQEYVTNK 439
            ++R++ + +  K     E E       K    KE  K  G  L K   +   +   T K
Sbjct: 365 RIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLK 424

Query: 440 TKKTEELRKTVEDLDGLIHQIYRDQD---LTQEIAMEHFVKKVEAAHCAACDLFIPMQFG 496
             + + +    +D       IY D+    + Q++  +   + +E   CAA ++   M+ G
Sbjct: 425 LLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMEL--CAAVEV---MEQG 479

Query: 497 IIQKHLKTMDHNRNRRLMMEQSKKSSL----MVARSILNNKLISKKLERYLKGENPFTDS 552
           + +K               E ++ + L     +A      K+   K+   +K ENP  + 
Sbjct: 480 VPEKEETPPPVEPEEE---EDTEDAGLDDWEAMASDEETEKVEGNKVHIEVK-ENPEEEE 535

Query: 553 PEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPP 605
            EEE+E+E+ E        + E  G SEG+EG      V  E   G      P
Sbjct: 536 EEEEEEEEDEE-----SEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKP 583



 Score = 37.4 bits (85), Expect = 0.043
 Identities = 50/203 (24%), Positives = 78/203 (38%), Gaps = 35/203 (17%)

Query: 277 KRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGT---------------EA 321
           ++++   P EP+ +    D  D    D +     E TE +EG                E 
Sbjct: 482 EKEETPPPVEPEEEE---DTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEE 538

Query: 322 VEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRD 381
            E+    + E+EE +E   E  + D E   ++ + ++G+T  K  + + S D +     D
Sbjct: 539 EEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDD 598

Query: 382 RMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGT-KLPKQTADFLQEYVTNKT 440
           R  E   +             + A     K   EH K V T KL       L    T KT
Sbjct: 599 RTKEERAY-------------DKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKT 645

Query: 441 KKTEELRKT-VED--LDGLIHQI 460
           K  ++LR T V+D    G+  QI
Sbjct: 646 KILDKLRHTHVQDGEAGGITQQI 668


>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
          Length = 1312

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 73/351 (20%), Positives = 131/351 (37%), Gaps = 51/351 (14%)

Query: 285 DEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGK 344
           D+P  +  R    D+ D    +  E E TE        E  S   GE+ E        G+
Sbjct: 291 DQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSH--GEEGEPSSIMNVPGE 348

Query: 345 EDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEM 404
               +  L  Q EN   K   +A K+ Q  Q+++QRD     I+ +    + R   + E 
Sbjct: 349 STLRREFLRLQQEN---KSNSEALKQQQQLQQQQQRDPEAH-IKHLLHQRQRRIEEQKEE 404

Query: 405 ASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQ 464
              ++ +  +E          ++     ++    + +  + LR+  E       Q Y+ +
Sbjct: 405 RRRVEEQQRRE----------REQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK 454

Query: 465 DLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLM 524
            L ++   E   ++++  H                 +LK++   + ++ + +Q ++  L 
Sbjct: 455 QLEEQRQSERLQRQLQQEHA----------------YLKSLQQQQQQQQLQKQQQQQLLP 498

Query: 525 VARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEG 584
             R         K L  Y +G NP  D P   +E EE     +++      A    G+ G
Sbjct: 499 GDR---------KPLYHYGRGMNP-ADKPAWAREVEERT--RMNKQQNSPLAKSKPGSTG 546

Query: 585 VPAQPPVPPEPAPGAVSP----PPPPPPEEEEEGAVPLLGGALQRQIRGIP 631
              +PP+P + +PG   P    PP   P E +EG    L     R +   P
Sbjct: 547 --PEPPIP-QASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFP 594


>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
          Length = 1096

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 69/308 (22%), Positives = 124/308 (40%), Gaps = 49/308 (15%)

Query: 341 EEGKEDPEKGALTTQDENGQTKR--KLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRT 398
           EE   D   GA+TT  E    +R   +  G ++Q+  + +     V  +QF+ +L    +
Sbjct: 287 EENILDKLLGAITTAAERNNRERFSPIVEGLENQEALQLQ-----VACMQFINALVT--S 339

Query: 399 FYEDEMASHLDSKFHKEHFKYVGTKLPKQTADFL-----------QEYVTNKTKKTEELR 447
            YE +   HL ++F +   K +   L ++  D L           ++ +T  + +  ++R
Sbjct: 340 PYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIR 399

Query: 448 KTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVEAAHCAACDLFI-PMQFGIIQK------ 500
             ++D++ + H +Y    L    A  +F+  ++       D +I P  + II++      
Sbjct: 400 AEMDDMNEVYHLLYNM--LKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIV 457

Query: 501 -HLKTMDHNRNRRLMME-------QSKKSSLMVARSILNNKLISKKL-ERYLKGENPFTD 551
            H   MD +   R  ++        S  +   V  S       SKK  E +   +    +
Sbjct: 458 LHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAE 517

Query: 552 SPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVP------PEPAP-----GAV 600
             + +++ +E E        Q +    S G  G PA PP+P      P PAP       +
Sbjct: 518 LQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPL 577

Query: 601 SPPPPPPP 608
            PPPPP P
Sbjct: 578 PPPPPPLP 585


>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
          Length = 1101

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 69/308 (22%), Positives = 124/308 (40%), Gaps = 49/308 (15%)

Query: 341 EEGKEDPEKGALTTQDENGQTKR--KLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRT 398
           EE   D   GA+TT  E    +R   +  G ++Q+  + +     V  +QF+ +L    +
Sbjct: 287 EENILDKLLGAITTAAERNNRERFSPIVEGLENQEALQLQ-----VACMQFINALVT--S 339

Query: 399 FYEDEMASHLDSKFHKEHFKYVGTKLPKQTADFL-----------QEYVTNKTKKTEELR 447
            YE +   HL ++F +   K +   L ++  D L           ++ +T  + +  ++R
Sbjct: 340 PYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIR 399

Query: 448 KTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVEAAHCAACDLFI-PMQFGIIQK------ 500
             ++D++ + H +Y    L    A  +F+  ++       D +I P  + II++      
Sbjct: 400 AEMDDMNEVYHLLYNM--LKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIV 457

Query: 501 -HLKTMDHNRNRRLMME-------QSKKSSLMVARSILNNKLISKKL-ERYLKGENPFTD 551
            H   MD +   R  ++        S  +   V  S       SKK  E +   +    +
Sbjct: 458 LHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAE 517

Query: 552 SPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVP------PEPAP-----GAV 600
             + +++ +E E        Q +    S G  G PA PP+P      P PAP       +
Sbjct: 518 LQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPL 577

Query: 601 SPPPPPPP 608
            PPPPP P
Sbjct: 578 PPPPPPLP 585


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 70/334 (20%), Positives = 127/334 (38%), Gaps = 51/334 (15%)

Query: 285 DEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGK 344
           D+P  +  R    D+ D    +  E E TE        E  S   GE+ E        G+
Sbjct: 291 DQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSH--GEEGEPSSIMNVPGE 348

Query: 345 EDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEM 404
               +  L  Q EN   K   +A K+ Q  Q+++QRD     I+ +    + R   + E 
Sbjct: 349 STLRREFLRLQQEN---KSNSEALKQQQQLQQQQQRDPEAH-IKHLLHQRQRRIEEQKEE 404

Query: 405 ASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQ 464
              ++ +  +E          ++     ++    + +  + LR+  E       Q Y+ +
Sbjct: 405 RRRVEEQQRRE----------REQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK 454

Query: 465 DLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLM 524
            L ++   E   ++++  H                 +LK++   + ++ + +Q ++  L 
Sbjct: 455 QLEEQRQSERLQRQLQQEHA----------------YLKSLQQQQQQQQLQKQQQQQLLP 498

Query: 525 VARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEG 584
             R         K L  Y +G NP  D P   +E EE     +++      A    G+ G
Sbjct: 499 GDR---------KPLYHYGRGMNP-ADKPAWAREVEERT--RMNKQQNSPLAKSKPGSTG 546

Query: 585 VPAQPPVPPEPAPGAVSP----PPPPPPEEEEEG 614
              +PP+P + +PG   P    PP   P E +EG
Sbjct: 547 --PEPPIP-QASPGPPGPLSQTPPMQRPVEPQEG 577


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 70/334 (20%), Positives = 127/334 (38%), Gaps = 51/334 (15%)

Query: 285 DEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGK 344
           D+P  +  R    D+ D    +  E E TE        E  S   GE+ E        G+
Sbjct: 291 DQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSH--GEEGEPSSIMNVPGE 348

Query: 345 EDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEM 404
               +  L  Q EN   K   +A K+ Q  Q+++QRD     I+ +    + R   + E 
Sbjct: 349 STLRREFLRLQQEN---KSNSEALKQQQQLQQQQQRDPEAH-IKHLLHQRQRRIEEQKEE 404

Query: 405 ASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQ 464
              ++ +  +E          ++     ++    + +  + LR+  E       Q Y+ +
Sbjct: 405 RRRVEEQQRRE----------REQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK 454

Query: 465 DLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLM 524
            L ++   E   ++++  H                 +LK++   + ++ + +Q ++  L 
Sbjct: 455 QLEEQRQSERLQRQLQQEHA----------------YLKSLQQQQQQQQLQKQQQQQLLP 498

Query: 525 VARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEG 584
             R         K L  Y +G NP  D P   +E EE     +++      A    G+ G
Sbjct: 499 GDR---------KPLYHYGRGMNP-ADKPAWAREVEERT--RMNKQQNSPLAKSKPGSTG 546

Query: 585 VPAQPPVPPEPAPGAVSP----PPPPPPEEEEEG 614
              +PP+P + +PG   P    PP   P E +EG
Sbjct: 547 --PEPPIP-QASPGPPGPLSQTPPMQRPVEPQEG 577


>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
          Length = 1295

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 70/334 (20%), Positives = 127/334 (38%), Gaps = 51/334 (15%)

Query: 285 DEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGK 344
           D+P  +  R    D+ D    +  E E TE        E  S   GE+ E        G+
Sbjct: 291 DQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSH--GEEGEPSSIMNVPGE 348

Query: 345 EDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEM 404
               +  L  Q EN   K   +A K+ Q  Q+++QRD     I+ +    + R   + E 
Sbjct: 349 STLRREFLRLQQEN---KSNSEALKQQQQLQQQQQRDPEAH-IKHLLHQRQRRIEEQKEE 404

Query: 405 ASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQ 464
              ++ +  +E          ++     ++    + +  + LR+  E       Q Y+ +
Sbjct: 405 RRRVEEQQRRE----------REQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK 454

Query: 465 DLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLM 524
            L ++   E   ++++  H                 +LK++   + ++ + +Q ++  L 
Sbjct: 455 QLEEQRQSERLQRQLQQEHA----------------YLKSLQQQQQQQQLQKQQQQQLLP 498

Query: 525 VARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEG 584
             R         K L  Y +G NP  D P   +E EE     +++      A    G+ G
Sbjct: 499 GDR---------KPLYHYGRGMNP-ADKPAWAREVEERT--RMNKQQNSPLAKSKPGSTG 546

Query: 585 VPAQPPVPPEPAPGAVSP----PPPPPPEEEEEG 614
              +PP+P + +PG   P    PP   P E +EG
Sbjct: 547 --PEPPIP-QASPGPPGPLSQTPPMQRPVEPQEG 577


>gi|60498973 myelin transcription factor 1-like [Homo sapiens]
          Length = 1184

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 32/112 (28%), Positives = 55/112 (49%), Gaps = 7/112 (6%)

Query: 275 KKKRKQGGSPDEPDSK----ATRTDCSDNSDSDNDEGTEG-EATEGLEGTEAVEKGSRVD 329
           KK++ Q   P EP  K    A + D S   + D+ +GTE  +  E  EG E  E      
Sbjct: 59  KKRKTQDKQPQEPAPKRKPFAVKADSSSVDECDDSDGTEDMDEKEEDEGEEYSEDNDEPG 118

Query: 330 GEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRD 381
            EDEE +E  REE +E  E+      DE+G+     +  ++ ++++++ + +
Sbjct: 119 DEDEEDEEGDREEEEEIEEED--EDDDEDGEDVEDEEEEEEEEEEEEEEEEN 168


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 27/100 (27%), Positives = 55/100 (55%), Gaps = 3/100 (3%)

Query: 282  GSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGRE 341
            G  +E + K          + + +EG EGE  +G EG E  E+    +GE+EEG+ +G E
Sbjct: 912  GEEEEGEGKGEEEGEEGEGEGEEEEG-EGEGEDG-EG-EGEEEEGEWEGEEEEGEGEGEE 968

Query: 342  EGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRD 381
            EG+ + E+G    ++E G+ + + + G++  +++ + + +
Sbjct: 969  EGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEE 1008



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 25/91 (27%), Positives = 52/91 (57%), Gaps = 8/91 (8%)

Query: 298  DNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDE 357
            +  + + +E  EGE  EG EG    E+G   +GE+EEG+E+G EEG+ + E      ++E
Sbjct: 960  EEGEGEGEEEGEGEGEEG-EGEGEEEEGEG-EGEEEEGEEEGEEEGEGEEEGEGEGEEEE 1017

Query: 358  NGQTKRKLQA------GKKSQDKQKKRQRDR 382
             G+ + +++       G++ + +++  +R++
Sbjct: 1018 EGEVEGEVEGEEGEGEGEEEEGEEEGEEREK 1048



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 38/174 (21%), Positives = 76/174 (43%), Gaps = 13/174 (7%)

Query: 275  KKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATE-GLEGTEAVEKGSRVDGEDE 333
            +++  +G   +E + +    +     +    EG E E  E G E  E  E+G     E+E
Sbjct: 958  EEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEE 1017

Query: 334  EGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSL 393
            EG+ +G  EG+E   +G     +E G+ + K   G++++  +++ + +            
Sbjct: 1018 EGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE----------- 1066

Query: 394  CKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELR 447
             KY+   E+E     D + +K+  K  G+    +   + ++ VTN     +E R
Sbjct: 1067 GKYQETGEEE-NERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQR 1119



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 25/112 (22%), Positives = 62/112 (55%), Gaps = 7/112 (6%)

Query: 272 RTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVD-- 329
           + + ++ ++GG  +  + +    D  +  + + +   EGE  E +EG    E+G R    
Sbjct: 721 KERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEE-VEGEREKEEGERKKEE 779

Query: 330 --GEDEEGKEDGRE-EGKEDPEKGALTTQDENGQTK-RKLQAGKKSQDKQKK 377
             G++E+G+E+G + EG+E+  +G    ++E G+ +  +++ GK  ++++++
Sbjct: 780 RAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEE 831



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 30/106 (28%), Positives = 58/106 (54%), Gaps = 11/106 (10%)

Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDE 333
           K++ +K+ G  +E + K          + + +EG E E  EG E     E+G R + E++
Sbjct: 699 KEEWKKRDG--EEQEQKEREQGHQKERNQEMEEGGEEEHGEGEE-----EEGDREEEEEK 751

Query: 334 EGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQ 379
           EG  +G+EEG+ +  +G    + E G+ K++ +AGK+ + +++  Q
Sbjct: 752 EG--EGKEEGEGEEVEG--EREKEEGERKKEERAGKEEKGEEEGDQ 793



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 4/79 (5%)

Query: 280 QGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDG 339
           +GG  +E   K  R +  +  + + +EG EGE  EG    E  E     +GE+ EG+E+G
Sbjct: 815 EGGEVEE--GKGEREEEEEEGEGEEEEG-EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEG 871

Query: 340 RE-EGKEDPEKGALTTQDE 357
            E EG+ + E+G    ++E
Sbjct: 872 EEGEGEGEEEEGEGEGEEE 890



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 28/102 (27%), Positives = 51/102 (50%), Gaps = 10/102 (9%)

Query: 282 GSPDEPDSKATRTDCSDNSDSDNDEGTEGEA----TEGLEGTEAVEKGSRVDGEDEEGK- 336
           G  ++ + +  + + +   +   +EG +GE     TEG  G E  E G    GE EEGK 
Sbjct: 766 GEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEG-RGEEKEEGGEVEGGEVEEGKG 824

Query: 337 --EDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQK 376
             E+  EEG+ + E+G    ++E G+ + +   GK  ++ ++
Sbjct: 825 EREEEEEEGEGEEEEG--EGEEEEGEGEEEEGEGKGEEEGEE 864



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 28/109 (25%), Positives = 55/109 (50%), Gaps = 8/109 (7%)

Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGS----RVD 329
           K++K ++ G   E + + T     +  +    EG E E  +G E  E  E+G       +
Sbjct: 783 KEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKG-EREEEEEEGEGEEEEGE 841

Query: 330 GEDEEGK---EDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQ 375
           GE+EEG+   E+G  +G+E+ E+G    + E G+ + + + G+   +++
Sbjct: 842 GEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEE 890



 Score = 37.4 bits (85), Expect = 0.043
 Identities = 26/107 (24%), Positives = 53/107 (49%), Gaps = 8/107 (7%)

Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDN----DEGTEGEATEGLEGTEAVEKGSRVD 329
           ++++ ++ G  +E + +    +     +       +EG EGE  E  EG E   +G   +
Sbjct: 825 EREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEE--EGEEGEGEGEEEE 882

Query: 330 GEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQK 376
           GE E G+E+G  EG+E+  +G    + E G+ + +   GK  ++ ++
Sbjct: 883 GEGE-GEEEGEGEGEEEEGEGEGEEEGE-GEGEEEEGEGKGEEEGEE 927



 Score = 37.0 bits (84), Expect = 0.057
 Identities = 23/103 (22%), Positives = 49/103 (47%), Gaps = 3/103 (2%)

Query: 275 KKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGS---RVDGE 331
           +++  +G   +E +      +  +      +E  EGE  E  EG    E+G      +GE
Sbjct: 850 EEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGE 909

Query: 332 DEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDK 374
            E  +E+G  +G+E+ E+G    ++E G+ + +   G+  +++
Sbjct: 910 GEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEE 952



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 26/114 (22%), Positives = 51/114 (44%), Gaps = 13/114 (11%)

Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDE 333
           K ++  + G  +E   +       +  + + +E  EGE  E  EG    E+    +GE+E
Sbjct: 857 KGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE-EGEGEGEEEGEGEGEEE 915

Query: 334 EGKEDGREEGKE------------DPEKGALTTQDENGQTKRKLQAGKKSQDKQ 375
           EG+  G EEG+E            + E G    ++E G+ + + + G+   +++
Sbjct: 916 EGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEE 969



 Score = 35.0 bits (79), Expect = 0.21
 Identities = 22/106 (20%), Positives = 48/106 (45%)

Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDE 333
           K K R +   P E + +    +     D +  E  E E     E  + +E+G   +  + 
Sbjct: 679 KDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEG 738

Query: 334 EGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQ 379
           E +E  REE +E   +G    + E  + +R+ + G++ ++++  ++
Sbjct: 739 EEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKE 784



 Score = 35.0 bits (79), Expect = 0.21
 Identities = 31/100 (31%), Positives = 40/100 (40%), Gaps = 10/100 (10%)

Query: 544 KGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPP 603
           +GE    +  E E E+EE EG   +EG +GE  G  E  EG         E   G     
Sbjct: 899 EGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWE-- 956

Query: 604 PPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGG 643
                EEE EG      G  + +  G  G    ++EEG G
Sbjct: 957 ---GEEEEGEGE-----GEEEGEGEGEEGEGEGEEEEGEG 988



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 29/105 (27%), Positives = 51/105 (48%), Gaps = 19/105 (18%)

Query: 295 DCSDNSD-SDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEG-------KEDGREEGKED 346
           D +D ++ S+    + GEA +G EG        R DG  EEG       +++ RE+G++D
Sbjct: 629 DLTDKAEVSEGKAKSVGEAEDGPEG--------RGDGTCEEGSSGAEHWQDEEREKGEKD 680

Query: 347 PEKGALTTQDENGQTKRKLQAGKK---SQDKQKKRQRDRMVERIQ 388
             +G +    E  +   + +  KK    + +QK+R++    ER Q
Sbjct: 681 KGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQ 725



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 28/113 (24%), Positives = 57/113 (50%), Gaps = 14/113 (12%)

Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEG--LEGTEAVE-KGSRVD- 329
           ++KK ++ G  ++ + +  + +     + +  EG   E  EG  +EG E  E KG R + 
Sbjct: 774 ERKKEERAGKEEKGEEEGDQGE----GEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEE 829

Query: 330 ---GEDEEGKEDGRE---EGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQK 376
              GE EE + +G E   EG+E+  +G    + E G+ + + + G+   ++++
Sbjct: 830 EEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEE 882



 Score = 33.5 bits (75), Expect = 0.62
 Identities = 25/109 (22%), Positives = 45/109 (41%), Gaps = 2/109 (1%)

Query: 272 RTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGE 331
           R K +K K  G  + P       + ++  +    +G E E  E  +G +        +G 
Sbjct: 674 REKGEKDKGRGEMERPGEG--EKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGG 731

Query: 332 DEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQR 380
           +EE  E   EEG  + E+       E G+ +      +K + ++KK +R
Sbjct: 732 EEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEER 780



 Score = 33.1 bits (74), Expect = 0.82
 Identities = 32/101 (31%), Positives = 43/101 (42%), Gaps = 11/101 (10%)

Query: 544 KGENPFTDSPEEEKEQ-EEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSP 602
           +GE   T+   EEKE+  E EGG ++EG +GE     E  EG   +     E   G    
Sbjct: 795 EGEEEETEGRGEEKEEGGEVEGGEVEEG-KGEREEEEEEGEGEEEEGEGEEEEGEG---- 849

Query: 603 PPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGG 643
                 EEE EG     G   + +  G  G    ++EEG G
Sbjct: 850 -----EEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEG 885



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 11/115 (9%)

Query: 276 KKRKQGGSPDEPDSKATRTDCSDNSDS----DNDEGTEGEATEGLEGTEAVEKGSRVDGE 331
           K +  G + D P+ +   T C + S       ++E  +GE  +G    E   +G +   E
Sbjct: 640 KAKSVGEAEDGPEGRGDGT-CEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAE 698

Query: 332 DEEGKE-DGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVE 385
            EE K+ DG E+ +++ E+G    Q E  Q     + G++   + ++ + DR  E
Sbjct: 699 KEEWKKRDGEEQEQKEREQG---HQKERNQEME--EGGEEEHGEGEEEEGDREEE 748



 Score = 31.6 bits (70), Expect = 2.4
 Identities = 33/107 (30%), Positives = 41/107 (38%), Gaps = 6/107 (5%)

Query: 537 KKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPA 596
           KK ER  K E    +  + E E+EE EG     G + E  G  EG E    +     E  
Sbjct: 776 KKEERAGKEEKGEEEGDQGEGEEEETEG----RGEEKEEGGEVEGGEVEEGKGEREEEEE 831

Query: 597 PGAVSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGG 643
            G          EEE EG      G  + +  G  G   E+ EEG G
Sbjct: 832 EGEGEEEEGEGEEEEGEGEEE--EGEGKGEEEGEEGEGEEEGEEGEG 876



 Score = 30.4 bits (67), Expect = 5.3
 Identities = 23/99 (23%), Positives = 46/99 (46%), Gaps = 6/99 (6%)

Query: 282 GSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAV---EKGSRVDGEDEEGKED 338
           G+ +E  S A      +    + D+G  GE     EG + +   E+  + DGE++E KE 
Sbjct: 657 GTCEEGSSGAEHWQDEEREKGEKDKG-RGEMERPGEGEKELAEKEEWKKRDGEEQEQKE- 714

Query: 339 GREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKK 377
            RE+G +      +    E    + + + G + ++++K+
Sbjct: 715 -REQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKE 752



 Score = 30.4 bits (67), Expect = 5.3
 Identities = 31/105 (29%), Positives = 43/105 (40%), Gaps = 6/105 (5%)

Query: 545 GENPFTDSPEEE---KEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVS 601
           GE    +  EEE   +E+EE EG   +EG   E  G  E  EG   +     +   G   
Sbjct: 731 GEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEE 790

Query: 602 PPPPPPPEEEEE--GAVPLLGGALQ-RQIRGIPGLDVEDDEEGGG 643
                  EEE E  G     GG ++  ++    G   E++EEG G
Sbjct: 791 GDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEG 835



 Score = 29.6 bits (65), Expect = 9.0
 Identities = 33/101 (32%), Positives = 38/101 (37%), Gaps = 5/101 (4%)

Query: 544 KGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPP 603
           +GE    +  EEE E EE EG    E    E  G  EG EG   +     E   G     
Sbjct: 834 EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEG---EGEGEEEEGEGEGEEE 890

Query: 604 PPPPPEEEE-EGAVPLLGGALQRQIRGIPGLDVEDDEEGGG 643
                EEEE EG     G     +  G  G   E+ EEG G
Sbjct: 891 GEGEGEEEEGEGEGEEEGEGEGEEEEG-EGKGEEEGEEGEG 930


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 90/410 (21%), Positives = 153/410 (37%), Gaps = 57/410 (13%)

Query: 256 MKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEG 315
           M   + +WK  T  +   +KK+RK+     E  ++  R   SD+ DS  D   EGE  + 
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKE----QEEKAEIKRLKNSDDRDSKRDSLEEGELRDH 56

Query: 316 -LEGTEAVEKGSRVDGEDEEGKEDG------------------REEGKEDPEKGALTTQD 356
            +E T       R D  ++ G+ED                   R++ K   +K A   + 
Sbjct: 57  CMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEK 116

Query: 357 ENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEH 416
           E    +RK    ++ QDK + R+ +R   R      + +  +  E +    L+ K  +E 
Sbjct: 117 EREHERRKRH--REEQDKAR-REWERQKRR-----EMAREHSRRERDRLEQLERKRERER 168

Query: 417 FKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFV 476
                 K+ +Q  +  Q     + ++ EE RK  E          R+         E + 
Sbjct: 169 ------KMREQQKE--QREQKERERRAEERRKERE--------ARREVSAHHRTMREDYS 212

Query: 477 KKVEAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLIS 536
            KV+A+H +      P +   +    K +   +    M E+   S L   + I +++  +
Sbjct: 213 DKVKASHWSRSPPRPPRERFELGDGRKPVKEEK----MEERDLLSDL---QDISDSERKT 265

Query: 537 KKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPA 596
              E         ++  EEE+E+EE EG   +E  + E     E  E   +      E +
Sbjct: 266 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE-EEEEEETGSNSEEASEQS 324

Query: 597 PGAVSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP 646
              VS       EE E     L+    + +     G   E +EE G G P
Sbjct: 325 AEEVSEEEMSEDEERENENHLLV--VPESRFDRDSGESEEAEEEVGEGTP 372


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 86/396 (21%), Positives = 147/396 (37%), Gaps = 30/396 (7%)

Query: 256 MKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEG 315
           M   + +WK  T  +   +KK+RK+     E  ++  R   SD+ DS  D   EGE  + 
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKE----QEEKAEIKRLKNSDDRDSKRDSLEEGELRDH 56

Query: 316 -LEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTT----QDENGQTKRKLQAGKK 370
            +E T       R D  ++ G+ED     K   +          +DE  + K K    K+
Sbjct: 57  CMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKE 116

Query: 371 SQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPKQTAD 430
            + +++KR R+   ++ +      K R    +      D     E  +    K+ +Q  +
Sbjct: 117 REHERRKRHREEQ-DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKE 175

Query: 431 FLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVEAAHCAACDLF 490
             Q     + ++ EE RK  E          R+         E +  KV+A+H +     
Sbjct: 176 --QREQKERERRAEERRKERE--------ARREVSAHHRTMREDYSDKVKASHWSRSPPR 225

Query: 491 IPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFT 550
            P +   +    K +   +    M E+   S L   + I +++  +   E         +
Sbjct: 226 PPRERFELGDGRKPVKEEK----MEERDLLSDL---QDISDSERKTSSAESSSAESGSGS 278

Query: 551 DSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEE 610
           +  EEE+E+EE EG   +E  + E     E  E   +      E +   VS       EE
Sbjct: 279 EEEEEEEEEEEEEGSTSEESEEEEEEE-EEEEEETGSNSEEASEQSAEEVSEEEMSEDEE 337

Query: 611 EEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP 646
            E     L+    + +     G   E +EE G G P
Sbjct: 338 RENENHLLV--VPESRFDRDSGESEEAEEEVGEGTP 371


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 81/400 (20%), Positives = 153/400 (38%), Gaps = 28/400 (7%)

Query: 256 MKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEG 315
           M   + +WK  T  +   +KK+RK+     E  ++  R   SD+ DS  D   EGE  + 
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKE----QEEKAEIKRLKNSDDRDSKRDSLEEGELRDH 56

Query: 316 -LEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDK 374
            +E T       R D  ++ G+ED     K   +             KRK +   + ++K
Sbjct: 57  CMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEK 116

Query: 375 QKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPKQTADFLQE 434
           +++ +R +     Q      K R  +E +    +  +  +      G  L +   + L+ 
Sbjct: 117 EREHERRKRHREEQD-----KARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLER 171

Query: 435 YVTNKTKKTEELRKTVE--DLDGLIHQIYRDQDLTQEIAMEH------FVKKVEAAHCAA 486
               + K  E+ ++  E  + +    +  ++++  +E++  H      +  KV+A+H + 
Sbjct: 172 KRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSR 231

Query: 487 CDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGE 546
                P +   +    K +   +    M E+   S L   + I +++  +   E      
Sbjct: 232 SPPRPPRERFELGDGRKPVKEEK----MEERDLLSDL---QDISDSERKTSSAESSSAES 284

Query: 547 NPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPP 606
              ++  EEE+E+EE EG   +E  + E     E  E   +      E +   VS     
Sbjct: 285 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEE-EEEEEETGSNSEEASEQSAEEVSEEEMS 343

Query: 607 PPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP 646
             EE E     L+    + +     G   E +EE G G P
Sbjct: 344 EDEERENENHLLV--VPESRFDRDSGESEEAEEEVGEGTP 381


>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
            sapiens]
          Length = 1130

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 30/81 (37%), Positives = 40/81 (49%), Gaps = 6/81 (7%)

Query: 540  ERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAG-ISEGAEGVPAQPP-VPPEPAP 597
            E + + E    +  EEE E+EE E   +++   G A G + EGA   P  PP +PP  +P
Sbjct: 933  EEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESP 992

Query: 598  GAVSPPPPPPP----EEEEEG 614
              V P P P P    E EE G
Sbjct: 993  PKVQPEPEPEPGLLLEVEEPG 1013



 Score = 36.2 bits (82), Expect = 0.096
 Identities = 26/65 (40%), Positives = 27/65 (41%), Gaps = 16/65 (24%)

Query: 587 AQPPVP----PEPAPGAVSP-PPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEG 641
           A PPVP    PE  P A  P PPPPPP     G V L            P   V +   G
Sbjct: 819 ASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTL-----------PPPQLVPEGTPG 867

Query: 642 GGGAP 646
           GGG P
Sbjct: 868 GGGPP 872



 Score = 33.5 bits (75), Expect = 0.62
 Identities = 24/62 (38%), Positives = 29/62 (46%), Gaps = 6/62 (9%)

Query: 582 AEGVPAQPPVPPEPAPGAVS-PPPPPPPEEEEEGAVPLLGGALQRQIR--GIPGLDVEDD 638
           A G    PP PP P PG V+ PPP   PE    G  P    AL+  +    I   D E++
Sbjct: 835 APGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGP---PALEEDLTVININSSDEEEE 891

Query: 639 EE 640
           EE
Sbjct: 892 EE 893



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 27/108 (25%), Positives = 55/108 (50%), Gaps = 6/108 (5%)

Query: 282 GSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGRE 341
           G+P      A   D +  + + +DE  E E  E  E  E  E+    + E+EE +E+  E
Sbjct: 864 GTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFE-EEEEDEEEYFE 922

Query: 342 EGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQF 389
           E +E+ E+     ++E G+    L+  ++ +D++++ + +  VE ++F
Sbjct: 923 EEEEEEEEFEEEFEEEEGE----LEEEEEEEDEEEEEELEE-VEDLEF 965


>gi|158420731 chromodomain helicase DNA binding protein 3 isoform 3
           [Homo sapiens]
          Length = 2059

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 30/98 (30%), Positives = 43/98 (43%), Gaps = 12/98 (12%)

Query: 540 ERYLKGENPFTDSPEEEKEQEEAEGGALD------EGAQGEAAGISEGAE-----GVPAQ 588
           E  +  E    +   +E+E+EE E    D      EG  G   G   G +     G    
Sbjct: 14  EMVVSEEEEEEEEEGDEEEEEEVEAADEDDEEDDDEGVLGRGPGHDRGRDRHSPPGCHLF 73

Query: 589 PPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQRQ 626
           PP PP P P    PPPPPPP++++   +P   G  +R+
Sbjct: 74  PPPPPPPPP-LPPPPPPPPPDKDDIRLLPSALGVKKRK 110



 Score = 31.2 bits (69), Expect = 3.1
 Identities = 29/107 (27%), Positives = 42/107 (39%), Gaps = 10/107 (9%)

Query: 511 RRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEG 570
           R L+ +++ K  +    +IL  K       R     NPF  S         A   A+   
Sbjct: 229 RPLIAKKNPKIPMSKMMTILGAKW------REFSANNPFKGSAAAVAAAAAAAAAAV--- 279

Query: 571 AQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVP 617
           A+  +A +S      P+ PP  P P P A   PPP    + +EG  P
Sbjct: 280 AEQVSAAVSSATPIAPSGPPALP-PPPAADIQPPPIRRAKTKEGKGP 325


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 84/407 (20%), Positives = 161/407 (39%), Gaps = 40/407 (9%)

Query: 256 MKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEG 315
           M   + +WK  T  +   +KK+RK+     E  ++  R   SD+ DS  D   EGE  + 
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKE----QEEKAEIKRLKNSDDRDSKRDSLEEGELRDH 56

Query: 316 -LEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTT----QDENGQTKRK-----L 365
            +E T       R D  ++ G+ED     K   +          +DE  + KR+      
Sbjct: 57  RMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSA 116

Query: 366 QAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGTKLP 425
           + GK ++ K+K+R+ +R     +      K R  +E +    +     +EH +    +L 
Sbjct: 117 EGGKHARVKEKEREHERRKRHRE---EQDKARREWERQKRREMA----REHSRRERDRLE 169

Query: 426 KQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEH------FVKKV 479
           +      +E    K ++ ++ ++  ++ +    +  ++++  +E++  H      +  KV
Sbjct: 170 QLERKRERE---RKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKV 226

Query: 480 EAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKL 539
           +A+H +      P +   +    K +   +    M E+   S L   + I +++  +   
Sbjct: 227 KASHWSRSPPRPPRERFELGDGRKPVKEEK----MEERDLLSDL---QDISDSERKTSSA 279

Query: 540 ERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGA 599
           E         ++  EEE+E+EE EG   +E  + E     E  E   +      E +   
Sbjct: 280 ESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE-EEEEEETGSNSEEASEQSAEE 338

Query: 600 VSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP 646
           VS       EE E     L+    + +     G   E +EE G G P
Sbjct: 339 VSEEEMSEDEERENENHLLV--VPESRFDRDSGESEEAEEEVGEGTP 383


>gi|4507353 TBP-associated factor 15 isoform 2 [Homo sapiens]
          Length = 589

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 58/228 (25%), Positives = 87/228 (38%), Gaps = 25/228 (10%)

Query: 28  DYGYGTWNSGTNRGYEGYGY--GYGYGQDNTTNYGYGMATSHSWEMPSSDTNANTSASGS 85
           D G    + G  + Y  YG     GYGQ + +  GYG  T  S+        +  S+ G 
Sbjct: 3   DSGSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSY----GQNYSGYSSYGQ 58

Query: 86  ASADSVLSRINQR---LDMVPHLETDMMQG-GVYGSGGERYDSYESCDSRAVLSERDLY- 140
           + + S     NQ+       P+      Q     GS G R  SY+  D      ++D Y 
Sbjct: 59  SYSQSYGGYENQKQSSYSQQPYNNQGQQQNMESSGSQGGRAPSYDQPD----YGQQDSYD 114

Query: 141 -RSGYDYSELDPEMEMAYEGQYDAYRDQFRMRGNDTFGPRAQGWARDARSGRPMASGYGR 199
            +SGYD  +   + +  Y+ Q+D+Y      +   ++  + + ++   +  R   S YG 
Sbjct: 115 QQSGYDQHQGSYDEQSNYDQQHDSY-----SQNQQSYHSQRENYSHHTQDDRRDVSRYG- 168

Query: 200 MWEDPMGARGQCMSGASRLPSLFSQNIIPEYGMFQGMRGGGAFPGGSR 247
             ED  G  G    G  R          P  G   G RGG    GG R
Sbjct: 169 --EDNRGYGGSQGGGRGR-GGYDKDGRGPMTGSSGGDRGGFKNFGGHR 213


>gi|21327701 TBP-associated factor 15 isoform 1 [Homo sapiens]
          Length = 592

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 59/227 (25%), Positives = 88/227 (38%), Gaps = 20/227 (8%)

Query: 28  DYGYGTWNSGTNRGYEGYGY--GYGYGQDNTTNYGYGMATSHSW-EMPSSDTNANTSASG 84
           D G    + G  + Y  YG     GYGQ + +  GYG  T  S+ +  S  ++   S SG
Sbjct: 3   DSGSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYGQNYSGYSSYGQSQSG 62

Query: 85  -SASADSVLSRINQRLDMVPHLETDMMQG-GVYGSGGERYDSYESCDSRAVLSERDLY-- 140
            S S     ++        P+      Q     GS G R  SY+  D      ++D Y  
Sbjct: 63  YSQSYGGYENQKQSSYSQQPYNNQGQQQNMESSGSQGGRAPSYDQPD----YGQQDSYDQ 118

Query: 141 RSGYDYSELDPEMEMAYEGQYDAYRDQFRMRGNDTFGPRAQGWARDARSGRPMASGYGRM 200
           +SGYD  +   + +  Y+ Q+D+Y      +   ++  + + ++   +  R   S YG  
Sbjct: 119 QSGYDQHQGSYDEQSNYDQQHDSY-----SQNQQSYHSQRENYSHHTQDDRRDVSRYG-- 171

Query: 201 WEDPMGARGQCMSGASRLPSLFSQNIIPEYGMFQGMRGGGAFPGGSR 247
            ED  G  G    G  R          P  G   G RGG    GG R
Sbjct: 172 -EDNRGYGGSQGGGRGR-GGYDKDGRGPMTGSSGGDRGGFKNFGGHR 216


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
           sapiens]
          Length = 2715

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 39/120 (32%), Positives = 47/120 (39%), Gaps = 31/120 (25%)

Query: 544 KGENPFTDSPEEEKEQEE--AEGGALDEGAQGE---AAGISEGAEGVP------------ 586
           K E    D  EE+KE+EE   EG   +E A  E    A   E A+  P            
Sbjct: 356 KQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPSPPP 415

Query: 587 -------------AQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGL 633
                          PP PP   P   SPPPPP  EE+EE   P++     R+ RG P L
Sbjct: 416 PLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQEESPPPVVPATCSRK-RGRPPL 474



 Score = 30.0 bits (66), Expect = 6.9
 Identities = 12/24 (50%), Positives = 13/24 (54%)

Query: 585 VPAQPPVPPEPAPGAVSPPPPPPP 608
           +   PPVP EPAP    P  P PP
Sbjct: 567 ITTSPPVPQEPAPVPSPPRAPTPP 590


>gi|83716024 kinesin family member 21B [Homo sapiens]
          Length = 1624

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 69/355 (19%), Positives = 127/355 (35%), Gaps = 23/355 (6%)

Query: 240 GAFPGGSRFGFGFGNGMKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDN 299
           GA P    FG    + M+      +       R KKK+ +Q     E ++   R      
Sbjct: 518 GASPAAPAFGGSPASSMEDASEVIRRAKQDLERLKKKEVRQRRKSPEKEAFKKRAKLQQE 577

Query: 300 SDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENG 359
           +  + DE    E  E  + +   E+  R D +++ G E+   +   DPE+  +  Q +  
Sbjct: 578 NSEETDENEAEEEEEERDESGCEEEEGREDEDEDSGSEESLVDSDSDPEEKEVNFQADLA 637

Query: 360 QTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKY 419
               +++  +K  D+ +  QR     + Q+            +E    L +K      + 
Sbjct: 638 DLTCEIEIKQKLIDELENSQRRLQTLKHQY------------EEKLILLQNKIRDTQLER 685

Query: 420 VGTKLPKQTADFLQEYVTNKTKKTEE--LRKTVEDLDGL-IHQIYRDQDLTQEIAMEHFV 476
                   T +   E   NK K   E  LR+   DL  L   Q    + L  +   E  +
Sbjct: 686 DRVLQNLSTMECYTEEKANKIKADYEKRLREMNRDLQKLQAAQKEHARLLKNQSRYEREL 745

Query: 477 KKVEA--AHCAACDLFIPMQFGIIQKHLKTMDHNRNRRL--MMEQSKKSSLMVARSILNN 532
           KK++A  A      + +  Q    Q+  + ++  RNR +  + ++ ++    +       
Sbjct: 746 KKLQAEVAEMKKAKVALMKQMREEQQRRRLVETKRNREIAQLKKEQRRQEFQIRALESQK 805

Query: 533 KLISKKLERYLKGENPFTDSPEEEKEQEEAEGG----ALDEGAQGEAAGISEGAE 583
           +     L R  +  +      +   E+     G     LD GA+  A+  S  AE
Sbjct: 806 RQQEMVLRRKTQEVSALRRLAKPMSERVAGRAGLKPPMLDSGAEVSASTTSSEAE 860


>gi|23503317 coiled-coil domain containing 96 [Homo sapiens]
          Length = 555

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 45/114 (39%), Positives = 56/114 (49%), Gaps = 17/114 (14%)

Query: 550 TDSPEEEKEQEEAEGG-ALDEGAQ-------GEAAG-ISEGAEGVPAQP-PVPPEPAP-G 598
           ++  EEE+EQ  ++GG A DE A+        EAAG    G  G PA+P P P EPA  G
Sbjct: 45  SEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVG 104

Query: 599 AVSPPPPPP---PE--EEEEGAVPLLGGALQRQIRGIPGLDV-EDDEEGGGGAP 646
           A  P  P P   PE  E E GA  L   A  +++R    L +   DEE    AP
Sbjct: 105 AEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAP 158



 Score = 31.2 bits (69), Expect = 3.1
 Identities = 26/77 (33%), Positives = 30/77 (38%), Gaps = 7/77 (9%)

Query: 569 EGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQRQIR 628
           EG  GE+           + PP  PEP  G +      P EEEEE A    G A   Q  
Sbjct: 14  EGGDGESLAARPSKIKASSGPPTSPEP--GELE---SEPEEEEEEQAASQGGTAADEQAE 68

Query: 629 GIPGLDVED--DEEGGG 643
              GL   +   EEG G
Sbjct: 69  APKGLTAAEAAGEEGPG 85


>gi|39812378 RAN binding protein 9 [Homo sapiens]
          Length = 729

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 30/82 (36%), Positives = 33/82 (40%), Gaps = 9/82 (10%)

Query: 565 GALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQ 624
           G+   GA GE  G+   A  +   PP PP PA  A  PPPPPPP      A P  G    
Sbjct: 49  GSPGGGAGGE--GLGAAAAALLLHPPPPPPPATAAPPPPPPPPP-PPASAAAPASGPPAP 105

Query: 625 RQIRGIPGLDVEDDEEGGGGAP 646
                 PGL       GG   P
Sbjct: 106 ------PGLAAGPGPAGGAPTP 121



 Score = 30.4 bits (67), Expect = 5.3
 Identities = 23/67 (34%), Positives = 24/67 (35%), Gaps = 9/67 (13%)

Query: 564 GGALDEGAQGEAAGI--------SEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGA 615
           GGA  EG    AA +               P  PP PP PA  A     PP P     G 
Sbjct: 53  GGAGGEGLGAAAAALLLHPPPPPPPATAAPPPPPPPPPPPASAAAPASGPPAPPGLAAGP 112

Query: 616 VPLLGGA 622
            P  GGA
Sbjct: 113 GP-AGGA 118


>gi|21361639 DIPB protein [Homo sapiens]
          Length = 344

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 42/201 (20%), Positives = 82/201 (40%), Gaps = 39/201 (19%)

Query: 280 QGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGE-DEEGKED 338
           +G   +E + K  +       + +++ G E E+ E  E  E  E     + E DEE +ED
Sbjct: 74  EGAGKEEAEVKVEQ-----EREIESEAGEESESEEESESEEESETEEESEDESDEESEED 128

Query: 339 GREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQ-DKQKKRQRDRMVER----------- 386
             EE +++ E  A     E G+++ + +   +S+ D + + + +R+ +R           
Sbjct: 129 SEEEMEDEQESEAEEDNQEEGESEAEGETEAESEFDPEIEMEAERVAKRKCPDHGLDLST 188

Query: 387 -----IQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVG----------------TKLP 425
                 Q +C LC     ++    S LD  F +   K  G                +  P
Sbjct: 189 YCQEDRQLICVLCPVIGAHQGHQLSTLDEAFEELRSKDSGGLKAAMIELVERLKFKSSDP 248

Query: 426 KQTADFLQEYVTNKTKKTEEL 446
           K T D ++ ++  + KK +++
Sbjct: 249 KVTRDQMKMFIQQEFKKVQKV 269


>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
           [Homo sapiens]
          Length = 651

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 74/393 (18%), Positives = 139/393 (35%), Gaps = 65/393 (16%)

Query: 254 NGMKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEAT 313
           N  K     +  +T  D +   KK     S D  D+K        N   D+ +    + T
Sbjct: 271 NNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDT 330

Query: 314 EGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTK------RKLQA 367
           E  +      K  R D + ++ K+  +++ K+D +K   +T  E+G  K      R L+ 
Sbjct: 331 ESTDAESGDSKDERKDTKKDK-KKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKK 389

Query: 368 GKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPKQ 427
             K+ DK+K  ++               + T  E E+ S    K  K+  K   T   K 
Sbjct: 390 ASKNDDKKKDAKK-------------ITFSTDSESELESKESQKDEKKDKKDSKTDNKK- 435

Query: 428 TADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVEAAHCAAC 487
                        K  EE      +  G   +  +D+   ++ + +   KK    +  + 
Sbjct: 436 -----------SVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAEST 484

Query: 488 DLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGEN 547
           ++   ++    +KH K  +   +++ + + ++K +         +     K    +KG +
Sbjct: 485 EMESDLELKKDKKHSK--EKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSD 542

Query: 548 PFTD----SPEEEKEQEEAEGGALDEGAQG----------------EAAGISEGAEGVPA 587
             ++     P  +K+ +E++G + +   +G                   G       VP 
Sbjct: 543 TESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPP 602

Query: 588 QPPVPPEPA--PGAVSPP---------PPPPPE 609
               PP PA  P   SP          PPPPP+
Sbjct: 603 SREKPPLPACEPSLPSPKVRRLCWCKMPPPPPK 635


>gi|7706687 Enah/Vasp-like [Homo sapiens]
          Length = 418

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 28/104 (26%), Positives = 38/104 (36%), Gaps = 18/104 (17%)

Query: 554 EEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPP------ 607
           E  + +  A G  L  G    AA       G P  PP P  P P   +PPPPPP      
Sbjct: 153 ESLERRTSATGPILPPGHPSSAASAPVSCSGPPPPPPPPVPPPPTGATPPPPPPLPAGGA 212

Query: 608 -----PEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP 646
                 E    G    + GA  R+++         ++  GG +P
Sbjct: 213 QGSSHDESSMSGLAAAIAGAKLRRVQ-------RPEDASGGSSP 249


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.131    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,697,832
Number of Sequences: 37866
Number of extensions: 1752108
Number of successful extensions: 33680
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 663
Number of HSP's successfully gapped in prelim test: 926
Number of HSP's that attempted gapping in prelim test: 17101
Number of HSP's gapped (non-prelim): 11685
length of query: 646
length of database: 18,247,518
effective HSP length: 109
effective length of query: 537
effective length of database: 14,120,124
effective search space: 7582506588
effective search space used: 7582506588
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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