BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|49472841 A kinase (PRKA) anchor protein 8-like [Homo sapiens] (646 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|49472841 A kinase (PRKA) anchor protein 8-like [Homo sapiens] 1335 0.0 gi|5031579 A-kinase anchor protein 8 [Homo sapiens] 299 6e-81 gi|33946297 zinc finger protein 326 isoform 1 [Homo sapiens] 172 9e-43 gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens] 52 1e-06 gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens] 52 1e-06 gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 50 5e-06 gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 49 1e-05 gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 49 2e-05 gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] 48 2e-05 gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] 48 2e-05 gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 48 3e-05 gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 48 3e-05 gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 48 3e-05 gi|60498973 myelin transcription factor 1-like [Homo sapiens] 47 4e-05 gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 47 5e-05 gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 47 5e-05 gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 46 1e-04 gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 46 1e-04 gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 45 2e-04 gi|158420731 chromodomain helicase DNA binding protein 3 isoform... 45 2e-04 gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 45 2e-04 gi|4507353 TBP-associated factor 15 isoform 2 [Homo sapiens] 44 4e-04 gi|21327701 TBP-associated factor 15 isoform 1 [Homo sapiens] 44 4e-04 gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 44 4e-04 gi|83716024 kinesin family member 21B [Homo sapiens] 44 4e-04 gi|23503317 coiled-coil domain containing 96 [Homo sapiens] 44 4e-04 gi|39812378 RAN binding protein 9 [Homo sapiens] 44 5e-04 gi|21361639 DIPB protein [Homo sapiens] 44 5e-04 gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 44 5e-04 gi|7706687 Enah/Vasp-like [Homo sapiens] 44 5e-04 >gi|49472841 A kinase (PRKA) anchor protein 8-like [Homo sapiens] Length = 646 Score = 1335 bits (3454), Expect = 0.0 Identities = 646/646 (100%), Positives = 646/646 (100%) Query: 1 MSYTGFVQGSETTLQSTYSDTSAQPTCDYGYGTWNSGTNRGYEGYGYGYGYGQDNTTNYG 60 MSYTGFVQGSETTLQSTYSDTSAQPTCDYGYGTWNSGTNRGYEGYGYGYGYGQDNTTNYG Sbjct: 1 MSYTGFVQGSETTLQSTYSDTSAQPTCDYGYGTWNSGTNRGYEGYGYGYGYGQDNTTNYG 60 Query: 61 YGMATSHSWEMPSSDTNANTSASGSASADSVLSRINQRLDMVPHLETDMMQGGVYGSGGE 120 YGMATSHSWEMPSSDTNANTSASGSASADSVLSRINQRLDMVPHLETDMMQGGVYGSGGE Sbjct: 61 YGMATSHSWEMPSSDTNANTSASGSASADSVLSRINQRLDMVPHLETDMMQGGVYGSGGE 120 Query: 121 RYDSYESCDSRAVLSERDLYRSGYDYSELDPEMEMAYEGQYDAYRDQFRMRGNDTFGPRA 180 RYDSYESCDSRAVLSERDLYRSGYDYSELDPEMEMAYEGQYDAYRDQFRMRGNDTFGPRA Sbjct: 121 RYDSYESCDSRAVLSERDLYRSGYDYSELDPEMEMAYEGQYDAYRDQFRMRGNDTFGPRA 180 Query: 181 QGWARDARSGRPMASGYGRMWEDPMGARGQCMSGASRLPSLFSQNIIPEYGMFQGMRGGG 240 QGWARDARSGRPMASGYGRMWEDPMGARGQCMSGASRLPSLFSQNIIPEYGMFQGMRGGG Sbjct: 181 QGWARDARSGRPMASGYGRMWEDPMGARGQCMSGASRLPSLFSQNIIPEYGMFQGMRGGG 240 Query: 241 AFPGGSRFGFGFGNGMKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNS 300 AFPGGSRFGFGFGNGMKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNS Sbjct: 241 AFPGGSRFGFGFGNGMKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNS 300 Query: 301 DSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQ 360 DSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQ Sbjct: 301 DSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQ 360 Query: 361 TKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYV 420 TKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYV Sbjct: 361 TKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYV 420 Query: 421 GTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVE 480 GTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVE Sbjct: 421 GTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVE 480 Query: 481 AAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLE 540 AAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLE Sbjct: 481 AAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLE 540 Query: 541 RYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAV 600 RYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAV Sbjct: 541 RYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAV 600 Query: 601 SPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP 646 SPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP Sbjct: 601 SPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP 646 >gi|5031579 A-kinase anchor protein 8 [Homo sapiens] Length = 692 Score = 299 bits (765), Expect = 6e-81 Identities = 238/693 (34%), Positives = 341/693 (49%), Gaps = 126/693 (18%) Query: 30 GYGTWNSGTN-------------RGYEGYGYGYGYGQDNTT-----NYGYGMATSHSWEM 71 GYG W++G +GYE Y Y YG NT+ Y YG A SWE Sbjct: 7 GYGAWSAGPANTQGAYGTGVASWQGYENYNY---YGAQNTSVTTGATYSYGPA---SWEA 60 Query: 72 PSSDTN---ANTSASGSAS---------ADSVLSRINQRLDMVPHLETDMMQGGVYGSGG 119 ++ A A AS +DS++++INQRLDM+ +GG GSGG Sbjct: 61 AKANDGGLAAGAPAMHMASYGPEPCTDNSDSLIAKINQRLDMMSK------EGGRGGSGG 114 Query: 120 E-----------RYDSYESCDSRAVLSERDLYRSGYDYS---ELDPEMEMAYEGQYDAYR 165 R+ +ES DSR L E + YR Y Y +L + ++ GQY R Sbjct: 115 GGEGIQDRESSFRFQPFESYDSRPCLPEHNPYRPSYSYDYEFDLGSDRNGSFGGQYSECR 174 Query: 166 DQFRMRGN-DTF-GPRAQGWARD----------------ARSGRPMASGYGRMWEDPMGA 207 D R RG+ D F R QG +D A S P+++ + + + +G Sbjct: 175 DPARERGSLDGFMRGRGQGRFQDRSNPGTFMRSDPFVPPAASSEPLSTPWNEL--NYVGG 232 Query: 208 RGQCMSGASRLP-SLFSQNIIPEYGMFQGMRGGGAFPGGSRFGFGFGNGMKQMRRTWKTW 266 RG SR P SLFSQ++ P+YG+ GM+G G + S +G G +MR + Sbjct: 233 RGLGGPSPSRPPPSLFSQSMAPDYGVM-GMQGAGGYD--STMPYGCGRSQPRMRDRDRPK 289 Query: 267 TTADFRTKK----KKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAV 322 R +KRKQ +EPD+K R D S+ S+ND+ G+ G E Sbjct: 290 RRGFDRFGPDGTGRKRKQFQLYEEPDTKLARVD-SEGDFSENDDAA-GDFRSGDE----- 342 Query: 323 EKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDR 382 GEDE + GR+ G+++ E DE+ + +R+ Q +++ R RDR Sbjct: 343 ----EFKGEDELC-DSGRQRGEKEDE-------DEDVKKRREKQ-------RRRDRTRDR 383 Query: 383 MVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKK 442 +RIQF CS+CK+R+F ++E+ HL SKFHKE +++ TKLP +T +FLQEY+ N+ KK Sbjct: 384 AADRIQFACSVCKFRSFDDEEIQKHLQSKFHKETLRFISTKLPDKTVEFLQEYIVNRNKK 443 Query: 443 TEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHL 502 E+ R+ + + + + D + I EHF KK+EAAHC ACD+ IP Q ++Q+HL Sbjct: 444 IEKRRQELMEKETAKPK----PDPFKGIGQEHFFKKIEAAHCLACDMLIPAQPQLLQRHL 499 Query: 503 KTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFT-DSPEEEKEQEE 561 ++DHN NRRL EQ KK+SL VA+S+LNN+ I K LE+YLKGE+PFT ++ + E E ++ Sbjct: 500 HSVDHNHNRRLAAEQFKKTSLHVAKSVLNNRHIVKMLEKYLKGEDPFTSETVDPEMEGDD 559 Query: 562 AEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPP----PPEEEEEGAVP 617 GG + E A A V E AP S P P + E G+ P Sbjct: 560 NLGGEDKKETPEEVAADVLAEVITAAVRAVDGEGAPAPESSGEPAEDEGPTDTAEAGSDP 619 Query: 618 LLGGALQRQI-------RGIPGLDVEDDEEGGG 643 L+ Q+ +G+P E E G G Sbjct: 620 QAEQLLEEQVPCGTAHEKGVPKARSEAAEAGNG 652 >gi|33946297 zinc finger protein 326 isoform 1 [Homo sapiens] Length = 582 Score = 172 bits (436), Expect = 9e-43 Identities = 164/602 (27%), Positives = 253/602 (42%), Gaps = 144/602 (23%) Query: 38 TNRGYEGYGYGYGYGQDNTTNYGYGMATSHSWEMPSSDTNANTSASGSASADSVLSRINQ 97 T +G+ G YG G + YG + S G S DS L NQ Sbjct: 15 TYQGFNGMDRDYGPGSYGGMDRDYG----------------HGSYGGQRSMDSYL---NQ 55 Query: 98 RLDMVPHLETDMMQGGVYGSGGERYDSYESCDSRAVLSERDLYRSGYDYSELDPEMEMAY 157 M H G GG R+ YES DSR+ L RDLYRSGY ++E PE + + Sbjct: 56 SYGMDNHSG---------GGGGSRFGPYESYDSRSSLGGRDLYRSGYGFNE--PE-QSRF 103 Query: 158 EGQYDAYRDQFRMRGNDTFGPRAQG---W-ARDARS----------GRPMASGYG----- 198 G Y + D+FG R QG W A +RS GR S Y Sbjct: 104 GGSYGGRFESSYRNSLDSFGGRNQGGSSWEAPYSRSKLRPGFMEDRGRENYSSYSSFSSP 163 Query: 199 RMWEDPMGARGQCMSGASRLP-SLFSQNIIPEYGMFQGMRGGGAFPGGSRFGFGFGNG-M 256 M P+G+RG+ G P S F G R AF GG G G G G M Sbjct: 164 HMKPAPVGSRGR---GTPAYPESTF------------GSRNYDAF-GGPSTGRGRGRGHM 207 Query: 257 KQMRRTWKTWTTADFRTKKK----------KRKQGGSPDEPDSKATRTDCSDNSDSDNDE 306 + D++ K KRK ++P + Sbjct: 208 GDFGSIHRPGIVVDYQNKSTNVTVAAARGIKRKMMQPFNKPSGTFIK------------- 254 Query: 307 GTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQ 366 + + + +E + ++ D ++EE + KR+++ Sbjct: 255 --KPKLAKPMEKISLSKSPTKTDPKNEE-------------------------EEKRRIE 287 Query: 367 AGKKSQDKQKKRQRDRMVE--RIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYV--GT 422 A ++ Q +++++ ++ + R+ F CS CK+RTF E ++ HL+S H+E ++ T Sbjct: 288 ARREKQRRRREKNSEKYGDGYRMAFTCSFCKFRTFEEKDIELHLESSSHQETLDHIQKQT 347 Query: 423 KLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVEAA 482 K K +FL E + NK KKT ++ + ++ I ++D+ + + ++ + KVE Sbjct: 348 KFDKVVMEFLHECMVNKFKKTSIRKQQTNNQTEVVKII--EKDVMEGVTVDDHMMKVETV 405 Query: 483 HCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERY 542 HC+AC ++IP +Q+HLK+ DH + ++ EQ K+ S++ A SILNN ++ + ER+ Sbjct: 406 HCSACSVYIPALHSSVQQHLKSPDHIKGKQAYKEQIKRESVLTATSILNNPIVKARYERF 465 Query: 543 LKGENPF--------------------TDSPEEEKEQEEAEGGALDEGAQGEAAGISEGA 582 +KGENPF D P EE+E E+ E A + G E + E Sbjct: 466 VKGENPFEIQDHSQDQQIEGDEEDEEKIDEPIEEEEDEDEEEEAEEVGEVEEVEEVEEVR 525 Query: 583 EG 584 EG Sbjct: 526 EG 527 >gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens] Length = 849 Score = 52.4 bits (124), Expect = 1e-06 Identities = 49/208 (23%), Positives = 81/208 (38%), Gaps = 32/208 (15%) Query: 432 LQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAME-----HFVKKVEAAHCAA 486 L+ + +K + EL +ED+ + + Y ++ E +F+ ++ Sbjct: 126 LKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIR 185 Query: 487 CDLFIPMQFG----------IIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLIS 536 D FI Q+ ++ + D +RL ++ ++ + + ++ L + Sbjct: 186 NDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLE-EFEE 244 Query: 537 KKLERYLKGENPFTDSPEEEKEQEEAEG----------------GALDEGAQGEAAGISE 580 K E Y K E FTD E + E ++ E GAL E Sbjct: 245 KASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKE 304 Query: 581 GAEGVPAQPPVPPEPAPGAVSPPPPPPP 608 G G A PP PP P+ G V PPPPPPP Sbjct: 305 GGTGHSALPPPPPLPSGGGVPPPPPPPP 332 >gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens] Length = 1193 Score = 52.4 bits (124), Expect = 1e-06 Identities = 49/208 (23%), Positives = 81/208 (38%), Gaps = 32/208 (15%) Query: 432 LQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAME-----HFVKKVEAAHCAA 486 L+ + +K + EL +ED+ + + Y ++ E +F+ ++ Sbjct: 389 LKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIR 448 Query: 487 CDLFIPMQFG----------IIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLIS 536 D FI Q+ ++ + D +RL ++ ++ + + ++ L + Sbjct: 449 NDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLE-EFEE 507 Query: 537 KKLERYLKGENPFTDSPEEEKEQEEAEG----------------GALDEGAQGEAAGISE 580 K E Y K E FTD E + E ++ E GAL E Sbjct: 508 KASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKE 567 Query: 581 GAEGVPAQPPVPPEPAPGAVSPPPPPPP 608 G G A PP PP P+ G V PPPPPPP Sbjct: 568 GGTGHSALPPPPPLPSGGGVPPPPPPPP 595 >gi|13540523 nucleosomal binding protein 1 [Homo sapiens] Length = 282 Score = 50.4 bits (119), Expect = 5e-06 Identities = 34/116 (29%), Positives = 59/116 (50%), Gaps = 7/116 (6%) Query: 277 KRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGK 336 K K+ G E D K D + + + +E E +G E + EKG + +G+D + K Sbjct: 171 KEKEDGKKGE-DGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVK 229 Query: 337 ED--GREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFV 390 ED RE+GKED E G ++E G+ K L+ ++ +++ + ++ D E Q + Sbjct: 230 EDEKEREDGKED-EGG---NEEEAGKEKEDLKEEEEGKEEDEIKEDDGKKEEPQSI 281 Score = 41.6 bits (96), Expect = 0.002 Identities = 27/85 (31%), Positives = 45/85 (52%), Gaps = 5/85 (5%) Query: 298 DNSDSDNDEGTEGEATEGLEGTE--AVEKGSRVDGEDEEGKEDGR--EEGKEDPEKGALT 353 D D + ++G G+ + +G E +K GED + KEDG+ E+GK + E G Sbjct: 133 DEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEK 192 Query: 354 TQDENGQTKRKLQA-GKKSQDKQKK 377 +DE + RK GK+++D ++K Sbjct: 193 GEDEKEEEDRKETGDGKENEDGKEK 217 Score = 36.6 bits (83), Expect = 0.074 Identities = 33/117 (28%), Positives = 59/117 (50%), Gaps = 15/117 (12%) Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLE-GTEAVEKGSRV---D 329 K +K ++ G D+ ++ D + D E +G +G E G + E+ R D Sbjct: 149 KDEKGEEDGKEDKNGNEKGE-DAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGD 207 Query: 330 G-EDEEGKEDG-REEG-----KEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQ 379 G E+E+GKE G ++EG KED ++ +DE G + +AGK+ +D +++ + Sbjct: 208 GKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEE---EAGKEKEDLKEEEE 261 Score = 35.0 bits (79), Expect = 0.21 Identities = 29/118 (24%), Positives = 56/118 (47%), Gaps = 20/118 (16%) Query: 270 DFRTKKKKRKQGGSPD-----EPDSKATRTDCSDNSDS-DNDEGTEGEATEGLEGTEAVE 323 D + +++ + G D E D K + D+ + ++G +GE +G G + E Sbjct: 133 DEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKG-NGEDGKE 191 Query: 324 KGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRD 381 KG EDE+ +ED +E G ++E+G+ K + GK + K+ +++R+ Sbjct: 192 KG-----EDEKEEEDRKETGD--------GKENEDGKEKGDKKEGKDVKVKEDEKERE 236 Score = 34.7 bits (78), Expect = 0.28 Identities = 38/119 (31%), Positives = 54/119 (45%), Gaps = 24/119 (20%) Query: 288 DSKATRTDCSDNSDSDNDEGTEGEATE-GLEGTEAV-------EKGSRVDGED------E 333 ++K T S+ + E +ATE G E EAV E+ + D ED E Sbjct: 84 EAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGE 143 Query: 334 EGKED----GREEGKEDP---EKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVE 385 GKED G E+GKED EKG + E+G +K + GK + + K++ D E Sbjct: 144 AGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDG---KKGEDGKGNGEDGKEKGEDEKEE 199 Score = 30.4 bits (67), Expect = 5.3 Identities = 20/81 (24%), Positives = 38/81 (46%), Gaps = 6/81 (7%) Query: 268 TADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSR 327 T D + + +++G + D K + +++ G E EA + E + E+G Sbjct: 205 TGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKE 264 Query: 328 VDGEDEEGKEDGREEGKEDPE 348 EDE ++DG+ KE+P+ Sbjct: 265 ---EDEIKEDDGK---KEEPQ 279 >gi|84043963 eukaryotic translation initiation factor 5B [Homo sapiens] Length = 1220 Score = 49.3 bits (116), Expect = 1e-05 Identities = 84/376 (22%), Positives = 148/376 (39%), Gaps = 70/376 (18%) Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDN-DEGTEG-EATEGLEGTEAVEKGSRVDGE 331 K K+ G DE +SK + NS ++ DE E ++ +G + + + G ++ Sbjct: 156 KSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESG 215 Query: 332 DEE--------------GKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKK 377 +E+ ++ RE K D EK L E K +L+ GKK Q KQK+ Sbjct: 216 NEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKE----KEELETGKKDQSKQKE 271 Query: 378 RQRDRMVERIQFVCSL-----------CKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPK 426 QR E ++ ++ + T ED+ + K K+ K G K K Sbjct: 272 SQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDD---NEGDKKKKDKKKKKGEKEEK 328 Query: 427 QTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVEAAHCAA 486 + K KK + TV+ + + ++ ++++ Q+ E +K++E Sbjct: 329 E-----------KEKKKGPSKATVKAMQEALAKL-KEEEERQKREEEERIKRLEELEAKR 376 Query: 487 CDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSIL--NNKLISKKLERYLK 544 ++ + R R+ E+ +K L +L + + + E LK Sbjct: 377 ------------KEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLK 424 Query: 545 ------GENPFTDS-PEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAP 597 E P DS P++ E+ + + + Q E+ +SE E + A V + P Sbjct: 425 LLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQ--QLESKEVSESME-LCAAVEVMEQGVP 481 Query: 598 GAVSPPPPPPPEEEEE 613 PPP PEEEE+ Sbjct: 482 EKEETPPPVEPEEEED 497 Score = 45.1 bits (105), Expect = 2e-04 Identities = 74/353 (20%), Positives = 140/353 (39%), Gaps = 40/353 (11%) Query: 272 RTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDN---DEGTEGEATEGLEGTEAVEKGSRV 328 + K+K+ + G D+ K ++ + + D G + E E A E Sbjct: 252 KLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAE----- 306 Query: 329 DGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGK------KSQDKQKKRQRDR 382 +D EG + +++ K+ EK + + G +K ++A + K +++++KR+ + Sbjct: 307 --DDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEE 364 Query: 383 MVERIQFVCSLCKYRTFYEDEMASHLDSKF--HKEHFKYVGTKLPKQTADF-LQEYVTNK 439 ++R++ + + K E E K KE K G L K + + T K Sbjct: 365 RIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLK 424 Query: 440 TKKTEELRKTVEDLDGLIHQIYRDQD---LTQEIAMEHFVKKVEAAHCAACDLFIPMQFG 496 + + + +D IY D+ + Q++ + + +E CAA ++ M+ G Sbjct: 425 LLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMEL--CAAVEV---MEQG 479 Query: 497 IIQKHLKTMDHNRNRRLMMEQSKKSSL----MVARSILNNKLISKKLERYLKGENPFTDS 552 + +K E ++ + L +A K+ K+ +K ENP + Sbjct: 480 VPEKEETPPPVEPEEE---EDTEDAGLDDWEAMASDEETEKVEGNKVHIEVK-ENPEEEE 535 Query: 553 PEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPP 605 EEE+E+E+ E + E G SEG+EG V E G P Sbjct: 536 EEEEEEEEDEE-----SEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKP 583 Score = 37.4 bits (85), Expect = 0.043 Identities = 50/203 (24%), Positives = 78/203 (38%), Gaps = 35/203 (17%) Query: 277 KRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGT---------------EA 321 ++++ P EP+ + D D D + E TE +EG E Sbjct: 482 EKEETPPPVEPEEEE---DTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEE 538 Query: 322 VEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRD 381 E+ + E+EE +E E + D E ++ + ++G+T K + + S D + D Sbjct: 539 EEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDD 598 Query: 382 RMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGT-KLPKQTADFLQEYVTNKT 440 R E + + A K EH K V T KL L T KT Sbjct: 599 RTKEERAY-------------DKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKT 645 Query: 441 KKTEELRKT-VED--LDGLIHQI 460 K ++LR T V+D G+ QI Sbjct: 646 KILDKLRHTHVQDGEAGGITQQI 668 >gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] Length = 1312 Score = 48.5 bits (114), Expect = 2e-05 Identities = 73/351 (20%), Positives = 131/351 (37%), Gaps = 51/351 (14%) Query: 285 DEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGK 344 D+P + R D+ D + E E TE E S GE+ E G+ Sbjct: 291 DQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSH--GEEGEPSSIMNVPGE 348 Query: 345 EDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEM 404 + L Q EN K +A K+ Q Q+++QRD I+ + + R + E Sbjct: 349 STLRREFLRLQQEN---KSNSEALKQQQQLQQQQQRDPEAH-IKHLLHQRQRRIEEQKEE 404 Query: 405 ASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQ 464 ++ + +E ++ ++ + + + LR+ E Q Y+ + Sbjct: 405 RRRVEEQQRRE----------REQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK 454 Query: 465 DLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLM 524 L ++ E ++++ H +LK++ + ++ + +Q ++ L Sbjct: 455 QLEEQRQSERLQRQLQQEHA----------------YLKSLQQQQQQQQLQKQQQQQLLP 498 Query: 525 VARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEG 584 R K L Y +G NP D P +E EE +++ A G+ G Sbjct: 499 GDR---------KPLYHYGRGMNP-ADKPAWAREVEERT--RMNKQQNSPLAKSKPGSTG 546 Query: 585 VPAQPPVPPEPAPGAVSP----PPPPPPEEEEEGAVPLLGGALQRQIRGIP 631 +PP+P + +PG P PP P E +EG L R + P Sbjct: 547 --PEPPIP-QASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFP 594 >gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] Length = 1096 Score = 48.1 bits (113), Expect = 2e-05 Identities = 69/308 (22%), Positives = 124/308 (40%), Gaps = 49/308 (15%) Query: 341 EEGKEDPEKGALTTQDENGQTKR--KLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRT 398 EE D GA+TT E +R + G ++Q+ + + V +QF+ +L + Sbjct: 287 EENILDKLLGAITTAAERNNRERFSPIVEGLENQEALQLQ-----VACMQFINALVT--S 339 Query: 399 FYEDEMASHLDSKFHKEHFKYVGTKLPKQTADFL-----------QEYVTNKTKKTEELR 447 YE + HL ++F + K + L ++ D L ++ +T + + ++R Sbjct: 340 PYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIR 399 Query: 448 KTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVEAAHCAACDLFI-PMQFGIIQK------ 500 ++D++ + H +Y L A +F+ ++ D +I P + II++ Sbjct: 400 AEMDDMNEVYHLLYNM--LKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIV 457 Query: 501 -HLKTMDHNRNRRLMME-------QSKKSSLMVARSILNNKLISKKL-ERYLKGENPFTD 551 H MD + R ++ S + V S SKK E + + + Sbjct: 458 LHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAE 517 Query: 552 SPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVP------PEPAP-----GAV 600 + +++ +E E Q + S G G PA PP+P P PAP + Sbjct: 518 LQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPL 577 Query: 601 SPPPPPPP 608 PPPPP P Sbjct: 578 PPPPPPLP 585 >gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] Length = 1101 Score = 48.1 bits (113), Expect = 2e-05 Identities = 69/308 (22%), Positives = 124/308 (40%), Gaps = 49/308 (15%) Query: 341 EEGKEDPEKGALTTQDENGQTKR--KLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRT 398 EE D GA+TT E +R + G ++Q+ + + V +QF+ +L + Sbjct: 287 EENILDKLLGAITTAAERNNRERFSPIVEGLENQEALQLQ-----VACMQFINALVT--S 339 Query: 399 FYEDEMASHLDSKFHKEHFKYVGTKLPKQTADFL-----------QEYVTNKTKKTEELR 447 YE + HL ++F + K + L ++ D L ++ +T + + ++R Sbjct: 340 PYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIR 399 Query: 448 KTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVEAAHCAACDLFI-PMQFGIIQK------ 500 ++D++ + H +Y L A +F+ ++ D +I P + II++ Sbjct: 400 AEMDDMNEVYHLLYNM--LKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIV 457 Query: 501 -HLKTMDHNRNRRLMME-------QSKKSSLMVARSILNNKLISKKL-ERYLKGENPFTD 551 H MD + R ++ S + V S SKK E + + + Sbjct: 458 LHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAE 517 Query: 552 SPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVP------PEPAP-----GAV 600 + +++ +E E Q + S G G PA PP+P P PAP + Sbjct: 518 LQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPL 577 Query: 601 SPPPPPPP 608 PPPPP P Sbjct: 578 PPPPPPLP 585 >gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] Length = 1303 Score = 47.8 bits (112), Expect = 3e-05 Identities = 70/334 (20%), Positives = 127/334 (38%), Gaps = 51/334 (15%) Query: 285 DEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGK 344 D+P + R D+ D + E E TE E S GE+ E G+ Sbjct: 291 DQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSH--GEEGEPSSIMNVPGE 348 Query: 345 EDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEM 404 + L Q EN K +A K+ Q Q+++QRD I+ + + R + E Sbjct: 349 STLRREFLRLQQEN---KSNSEALKQQQQLQQQQQRDPEAH-IKHLLHQRQRRIEEQKEE 404 Query: 405 ASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQ 464 ++ + +E ++ ++ + + + LR+ E Q Y+ + Sbjct: 405 RRRVEEQQRRE----------REQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK 454 Query: 465 DLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLM 524 L ++ E ++++ H +LK++ + ++ + +Q ++ L Sbjct: 455 QLEEQRQSERLQRQLQQEHA----------------YLKSLQQQQQQQQLQKQQQQQLLP 498 Query: 525 VARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEG 584 R K L Y +G NP D P +E EE +++ A G+ G Sbjct: 499 GDR---------KPLYHYGRGMNP-ADKPAWAREVEERT--RMNKQQNSPLAKSKPGSTG 546 Query: 585 VPAQPPVPPEPAPGAVSP----PPPPPPEEEEEG 614 +PP+P + +PG P PP P E +EG Sbjct: 547 --PEPPIP-QASPGPPGPLSQTPPMQRPVEPQEG 577 >gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] Length = 1332 Score = 47.8 bits (112), Expect = 3e-05 Identities = 70/334 (20%), Positives = 127/334 (38%), Gaps = 51/334 (15%) Query: 285 DEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGK 344 D+P + R D+ D + E E TE E S GE+ E G+ Sbjct: 291 DQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSH--GEEGEPSSIMNVPGE 348 Query: 345 EDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEM 404 + L Q EN K +A K+ Q Q+++QRD I+ + + R + E Sbjct: 349 STLRREFLRLQQEN---KSNSEALKQQQQLQQQQQRDPEAH-IKHLLHQRQRRIEEQKEE 404 Query: 405 ASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQ 464 ++ + +E ++ ++ + + + LR+ E Q Y+ + Sbjct: 405 RRRVEEQQRRE----------REQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK 454 Query: 465 DLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLM 524 L ++ E ++++ H +LK++ + ++ + +Q ++ L Sbjct: 455 QLEEQRQSERLQRQLQQEHA----------------YLKSLQQQQQQQQLQKQQQQQLLP 498 Query: 525 VARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEG 584 R K L Y +G NP D P +E EE +++ A G+ G Sbjct: 499 GDR---------KPLYHYGRGMNP-ADKPAWAREVEERT--RMNKQQNSPLAKSKPGSTG 546 Query: 585 VPAQPPVPPEPAPGAVSP----PPPPPPEEEEEG 614 +PP+P + +PG P PP P E +EG Sbjct: 547 --PEPPIP-QASPGPPGPLSQTPPMQRPVEPQEG 577 >gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] Length = 1295 Score = 47.8 bits (112), Expect = 3e-05 Identities = 70/334 (20%), Positives = 127/334 (38%), Gaps = 51/334 (15%) Query: 285 DEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGK 344 D+P + R D+ D + E E TE E S GE+ E G+ Sbjct: 291 DQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSH--GEEGEPSSIMNVPGE 348 Query: 345 EDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEM 404 + L Q EN K +A K+ Q Q+++QRD I+ + + R + E Sbjct: 349 STLRREFLRLQQEN---KSNSEALKQQQQLQQQQQRDPEAH-IKHLLHQRQRRIEEQKEE 404 Query: 405 ASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQ 464 ++ + +E ++ ++ + + + LR+ E Q Y+ + Sbjct: 405 RRRVEEQQRRE----------REQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK 454 Query: 465 DLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLM 524 L ++ E ++++ H +LK++ + ++ + +Q ++ L Sbjct: 455 QLEEQRQSERLQRQLQQEHA----------------YLKSLQQQQQQQQLQKQQQQQLLP 498 Query: 525 VARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEG 584 R K L Y +G NP D P +E EE +++ A G+ G Sbjct: 499 GDR---------KPLYHYGRGMNP-ADKPAWAREVEERT--RMNKQQNSPLAKSKPGSTG 546 Query: 585 VPAQPPVPPEPAPGAVSP----PPPPPPEEEEEG 614 +PP+P + +PG P PP P E +EG Sbjct: 547 --PEPPIP-QASPGPPGPLSQTPPMQRPVEPQEG 577 >gi|60498973 myelin transcription factor 1-like [Homo sapiens] Length = 1184 Score = 47.4 bits (111), Expect = 4e-05 Identities = 32/112 (28%), Positives = 55/112 (49%), Gaps = 7/112 (6%) Query: 275 KKKRKQGGSPDEPDSK----ATRTDCSDNSDSDNDEGTEG-EATEGLEGTEAVEKGSRVD 329 KK++ Q P EP K A + D S + D+ +GTE + E EG E E Sbjct: 59 KKRKTQDKQPQEPAPKRKPFAVKADSSSVDECDDSDGTEDMDEKEEDEGEEYSEDNDEPG 118 Query: 330 GEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRD 381 EDEE +E REE +E E+ DE+G+ + ++ ++++++ + + Sbjct: 119 DEDEEDEEGDREEEEEIEEED--EDDDEDGEDVEDEEEEEEEEEEEEEEEEN 168 >gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo sapiens] Length = 1152 Score = 47.0 bits (110), Expect = 5e-05 Identities = 27/100 (27%), Positives = 55/100 (55%), Gaps = 3/100 (3%) Query: 282 GSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGRE 341 G +E + K + + +EG EGE +G EG E E+ +GE+EEG+ +G E Sbjct: 912 GEEEEGEGKGEEEGEEGEGEGEEEEG-EGEGEDG-EG-EGEEEEGEWEGEEEEGEGEGEE 968 Query: 342 EGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRD 381 EG+ + E+G ++E G+ + + + G++ +++ + + + Sbjct: 969 EGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEE 1008 Score = 45.8 bits (107), Expect = 1e-04 Identities = 25/91 (27%), Positives = 52/91 (57%), Gaps = 8/91 (8%) Query: 298 DNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDE 357 + + + +E EGE EG EG E+G +GE+EEG+E+G EEG+ + E ++E Sbjct: 960 EEGEGEGEEEGEGEGEEG-EGEGEEEEGEG-EGEEEEGEEEGEEEGEGEEEGEGEGEEEE 1017 Query: 358 NGQTKRKLQA------GKKSQDKQKKRQRDR 382 G+ + +++ G++ + +++ +R++ Sbjct: 1018 EGEVEGEVEGEEGEGEGEEEEGEEEGEEREK 1048 Score = 43.9 bits (102), Expect = 5e-04 Identities = 38/174 (21%), Positives = 76/174 (43%), Gaps = 13/174 (7%) Query: 275 KKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATE-GLEGTEAVEKGSRVDGEDE 333 +++ +G +E + + + + EG E E E G E E E+G E+E Sbjct: 958 EEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEE 1017 Query: 334 EGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSL 393 EG+ +G EG+E +G +E G+ + K G++++ +++ + + Sbjct: 1018 EGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE----------- 1066 Query: 394 CKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELR 447 KY+ E+E D + +K+ K G+ + + ++ VTN +E R Sbjct: 1067 GKYQETGEEE-NERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQR 1119 Score = 43.5 bits (101), Expect = 6e-04 Identities = 25/112 (22%), Positives = 62/112 (55%), Gaps = 7/112 (6%) Query: 272 RTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVD-- 329 + + ++ ++GG + + + D + + + + EGE E +EG E+G R Sbjct: 721 KERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEE-VEGEREKEEGERKKEE 779 Query: 330 --GEDEEGKEDGRE-EGKEDPEKGALTTQDENGQTK-RKLQAGKKSQDKQKK 377 G++E+G+E+G + EG+E+ +G ++E G+ + +++ GK ++++++ Sbjct: 780 RAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEE 831 Score = 42.4 bits (98), Expect = 0.001 Identities = 30/106 (28%), Positives = 58/106 (54%), Gaps = 11/106 (10%) Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDE 333 K++ +K+ G +E + K + + +EG E E EG E E+G R + E++ Sbjct: 699 KEEWKKRDG--EEQEQKEREQGHQKERNQEMEEGGEEEHGEGEE-----EEGDREEEEEK 751 Query: 334 EGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQ 379 EG +G+EEG+ + +G + E G+ K++ +AGK+ + +++ Q Sbjct: 752 EG--EGKEEGEGEEVEG--EREKEEGERKKEERAGKEEKGEEEGDQ 793 Score = 39.7 bits (91), Expect = 0.009 Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 4/79 (5%) Query: 280 QGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDG 339 +GG +E K R + + + + +EG EGE EG E E +GE+ EG+E+G Sbjct: 815 EGGEVEE--GKGEREEEEEEGEGEEEEG-EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEG 871 Query: 340 RE-EGKEDPEKGALTTQDE 357 E EG+ + E+G ++E Sbjct: 872 EEGEGEGEEEEGEGEGEEE 890 Score = 38.9 bits (89), Expect = 0.015 Identities = 28/102 (27%), Positives = 51/102 (50%), Gaps = 10/102 (9%) Query: 282 GSPDEPDSKATRTDCSDNSDSDNDEGTEGEA----TEGLEGTEAVEKGSRVDGEDEEGK- 336 G ++ + + + + + + +EG +GE TEG G E E G GE EEGK Sbjct: 766 GEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEG-RGEEKEEGGEVEGGEVEEGKG 824 Query: 337 --EDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQK 376 E+ EEG+ + E+G ++E G+ + + GK ++ ++ Sbjct: 825 EREEEEEEGEGEEEEG--EGEEEEGEGEEEEGEGKGEEEGEE 864 Score = 38.9 bits (89), Expect = 0.015 Identities = 28/109 (25%), Positives = 55/109 (50%), Gaps = 8/109 (7%) Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGS----RVD 329 K++K ++ G E + + T + + EG E E +G E E E+G + Sbjct: 783 KEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKG-EREEEEEEGEGEEEEGE 841 Query: 330 GEDEEGK---EDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQ 375 GE+EEG+ E+G +G+E+ E+G + E G+ + + + G+ +++ Sbjct: 842 GEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEE 890 Score = 37.4 bits (85), Expect = 0.043 Identities = 26/107 (24%), Positives = 53/107 (49%), Gaps = 8/107 (7%) Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDN----DEGTEGEATEGLEGTEAVEKGSRVD 329 ++++ ++ G +E + + + + +EG EGE E EG E +G + Sbjct: 825 EREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEE--EGEEGEGEGEEEE 882 Query: 330 GEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQK 376 GE E G+E+G EG+E+ +G + E G+ + + GK ++ ++ Sbjct: 883 GEGE-GEEEGEGEGEEEEGEGEGEEEGE-GEGEEEEGEGKGEEEGEE 927 Score = 37.0 bits (84), Expect = 0.057 Identities = 23/103 (22%), Positives = 49/103 (47%), Gaps = 3/103 (2%) Query: 275 KKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGS---RVDGE 331 +++ +G +E + + + +E EGE E EG E+G +GE Sbjct: 850 EEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGE 909 Query: 332 DEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDK 374 E +E+G +G+E+ E+G ++E G+ + + G+ +++ Sbjct: 910 GEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEE 952 Score = 35.8 bits (81), Expect = 0.13 Identities = 26/114 (22%), Positives = 51/114 (44%), Gaps = 13/114 (11%) Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDE 333 K ++ + G +E + + + + +E EGE E EG E+ +GE+E Sbjct: 857 KGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE-EGEGEGEEEGEGEGEEE 915 Query: 334 EGKEDGREEGKE------------DPEKGALTTQDENGQTKRKLQAGKKSQDKQ 375 EG+ G EEG+E + E G ++E G+ + + + G+ +++ Sbjct: 916 EGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEE 969 Score = 35.0 bits (79), Expect = 0.21 Identities = 22/106 (20%), Positives = 48/106 (45%) Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDE 333 K K R + P E + + + D + E E E E + +E+G + + Sbjct: 679 KDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEG 738 Query: 334 EGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQ 379 E +E REE +E +G + E + +R+ + G++ ++++ ++ Sbjct: 739 EEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKE 784 Score = 35.0 bits (79), Expect = 0.21 Identities = 31/100 (31%), Positives = 40/100 (40%), Gaps = 10/100 (10%) Query: 544 KGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPP 603 +GE + E E E+EE EG +EG +GE G E EG E G Sbjct: 899 EGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWE-- 956 Query: 604 PPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGG 643 EEE EG G + + G G ++EEG G Sbjct: 957 ---GEEEEGEGE-----GEEEGEGEGEEGEGEGEEEEGEG 988 Score = 34.7 bits (78), Expect = 0.28 Identities = 29/105 (27%), Positives = 51/105 (48%), Gaps = 19/105 (18%) Query: 295 DCSDNSD-SDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEG-------KEDGREEGKED 346 D +D ++ S+ + GEA +G EG R DG EEG +++ RE+G++D Sbjct: 629 DLTDKAEVSEGKAKSVGEAEDGPEG--------RGDGTCEEGSSGAEHWQDEEREKGEKD 680 Query: 347 PEKGALTTQDENGQTKRKLQAGKK---SQDKQKKRQRDRMVERIQ 388 +G + E + + + KK + +QK+R++ ER Q Sbjct: 681 KGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQ 725 Score = 34.7 bits (78), Expect = 0.28 Identities = 28/113 (24%), Positives = 57/113 (50%), Gaps = 14/113 (12%) Query: 274 KKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEG--LEGTEAVE-KGSRVD- 329 ++KK ++ G ++ + + + + + + EG E EG +EG E E KG R + Sbjct: 774 ERKKEERAGKEEKGEEEGDQGE----GEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEE 829 Query: 330 ---GEDEEGKEDGRE---EGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQK 376 GE EE + +G E EG+E+ +G + E G+ + + + G+ ++++ Sbjct: 830 EEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEE 882 Score = 33.5 bits (75), Expect = 0.62 Identities = 25/109 (22%), Positives = 45/109 (41%), Gaps = 2/109 (1%) Query: 272 RTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGE 331 R K +K K G + P + ++ + +G E E E +G + +G Sbjct: 674 REKGEKDKGRGEMERPGEG--EKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGG 731 Query: 332 DEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQR 380 +EE E EEG + E+ E G+ + +K + ++KK +R Sbjct: 732 EEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEER 780 Score = 33.1 bits (74), Expect = 0.82 Identities = 32/101 (31%), Positives = 43/101 (42%), Gaps = 11/101 (10%) Query: 544 KGENPFTDSPEEEKEQ-EEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSP 602 +GE T+ EEKE+ E EGG ++EG +GE E EG + E G Sbjct: 795 EGEEEETEGRGEEKEEGGEVEGGEVEEG-KGEREEEEEEGEGEEEEGEGEEEEGEG---- 849 Query: 603 PPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGG 643 EEE EG G + + G G ++EEG G Sbjct: 850 -----EEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEG 885 Score = 32.7 bits (73), Expect = 1.1 Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 11/115 (9%) Query: 276 KKRKQGGSPDEPDSKATRTDCSDNSDS----DNDEGTEGEATEGLEGTEAVEKGSRVDGE 331 K + G + D P+ + T C + S ++E +GE +G E +G + E Sbjct: 640 KAKSVGEAEDGPEGRGDGT-CEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAE 698 Query: 332 DEEGKE-DGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVE 385 EE K+ DG E+ +++ E+G Q E Q + G++ + ++ + DR E Sbjct: 699 KEEWKKRDGEEQEQKEREQG---HQKERNQEME--EGGEEEHGEGEEEEGDREEE 748 Score = 31.6 bits (70), Expect = 2.4 Identities = 33/107 (30%), Positives = 41/107 (38%), Gaps = 6/107 (5%) Query: 537 KKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPA 596 KK ER K E + + E E+EE EG G + E G EG E + E Sbjct: 776 KKEERAGKEEKGEEEGDQGEGEEEETEG----RGEEKEEGGEVEGGEVEEGKGEREEEEE 831 Query: 597 PGAVSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGG 643 G EEE EG G + + G G E+ EEG G Sbjct: 832 EGEGEEEEGEGEEEEGEGEEE--EGEGKGEEEGEEGEGEEEGEEGEG 876 Score = 30.4 bits (67), Expect = 5.3 Identities = 23/99 (23%), Positives = 46/99 (46%), Gaps = 6/99 (6%) Query: 282 GSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAV---EKGSRVDGEDEEGKED 338 G+ +E S A + + D+G GE EG + + E+ + DGE++E KE Sbjct: 657 GTCEEGSSGAEHWQDEEREKGEKDKG-RGEMERPGEGEKELAEKEEWKKRDGEEQEQKE- 714 Query: 339 GREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKK 377 RE+G + + E + + + G + ++++K+ Sbjct: 715 -REQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKE 752 Score = 30.4 bits (67), Expect = 5.3 Identities = 31/105 (29%), Positives = 43/105 (40%), Gaps = 6/105 (5%) Query: 545 GENPFTDSPEEE---KEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVS 601 GE + EEE +E+EE EG +EG E G E EG + + G Sbjct: 731 GEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEE 790 Query: 602 PPPPPPPEEEEE--GAVPLLGGALQ-RQIRGIPGLDVEDDEEGGG 643 EEE E G GG ++ ++ G E++EEG G Sbjct: 791 GDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEG 835 Score = 29.6 bits (65), Expect = 9.0 Identities = 33/101 (32%), Positives = 38/101 (37%), Gaps = 5/101 (4%) Query: 544 KGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPP 603 +GE + EEE E EE EG E E G EG EG + E G Sbjct: 834 EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEG---EGEGEEEEGEGEGEEE 890 Query: 604 PPPPPEEEE-EGAVPLLGGALQRQIRGIPGLDVEDDEEGGG 643 EEEE EG G + G G E+ EEG G Sbjct: 891 GEGEGEEEEGEGEGEEEGEGEGEEEEG-EGKGEEEGEEGEG 930 >gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform 9 [Homo sapiens] Length = 771 Score = 47.0 bits (110), Expect = 5e-05 Identities = 90/410 (21%), Positives = 153/410 (37%), Gaps = 57/410 (13%) Query: 256 MKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEG 315 M + +WK T + +KK+RK+ E ++ R SD+ DS D EGE + Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKE----QEEKAEIKRLKNSDDRDSKRDSLEEGELRDH 56 Query: 316 -LEGTEAVEKGSRVDGEDEEGKEDG------------------REEGKEDPEKGALTTQD 356 +E T R D ++ G+ED R++ K +K A + Sbjct: 57 CMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEK 116 Query: 357 ENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEH 416 E +RK ++ QDK + R+ +R R + + + E + L+ K +E Sbjct: 117 EREHERRKRH--REEQDKAR-REWERQKRR-----EMAREHSRRERDRLEQLERKRERER 168 Query: 417 FKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFV 476 K+ +Q + Q + ++ EE RK E R+ E + Sbjct: 169 ------KMREQQKE--QREQKERERRAEERRKERE--------ARREVSAHHRTMREDYS 212 Query: 477 KKVEAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLIS 536 KV+A+H + P + + K + + M E+ S L + I +++ + Sbjct: 213 DKVKASHWSRSPPRPPRERFELGDGRKPVKEEK----MEERDLLSDL---QDISDSERKT 265 Query: 537 KKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPA 596 E ++ EEE+E+EE EG +E + E E E + E + Sbjct: 266 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE-EEEEEETGSNSEEASEQS 324 Query: 597 PGAVSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP 646 VS EE E L+ + + G E +EE G G P Sbjct: 325 AEEVSEEEMSEDEERENENHLLV--VPESRFDRDSGESEEAEEEVGEGTP 372 >gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] Length = 770 Score = 45.8 bits (107), Expect = 1e-04 Identities = 86/396 (21%), Positives = 147/396 (37%), Gaps = 30/396 (7%) Query: 256 MKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEG 315 M + +WK T + +KK+RK+ E ++ R SD+ DS D EGE + Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKE----QEEKAEIKRLKNSDDRDSKRDSLEEGELRDH 56 Query: 316 -LEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTT----QDENGQTKRKLQAGKK 370 +E T R D ++ G+ED K + +DE + K K K+ Sbjct: 57 CMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKE 116 Query: 371 SQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPKQTAD 430 + +++KR R+ ++ + K R + D E + K+ +Q + Sbjct: 117 REHERRKRHREEQ-DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKE 175 Query: 431 FLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVEAAHCAACDLF 490 Q + ++ EE RK E R+ E + KV+A+H + Sbjct: 176 --QREQKERERRAEERRKERE--------ARREVSAHHRTMREDYSDKVKASHWSRSPPR 225 Query: 491 IPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFT 550 P + + K + + M E+ S L + I +++ + E + Sbjct: 226 PPRERFELGDGRKPVKEEK----MEERDLLSDL---QDISDSERKTSSAESSSAESGSGS 278 Query: 551 DSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEE 610 + EEE+E+EE EG +E + E E E + E + VS EE Sbjct: 279 EEEEEEEEEEEEEGSTSEESEEEEEEE-EEEEEETGSNSEEASEQSAEEVSEEEMSEDEE 337 Query: 611 EEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP 646 E L+ + + G E +EE G G P Sbjct: 338 RENENHLLV--VPESRFDRDSGESEEAEEEVGEGTP 371 >gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform 8 [Homo sapiens] Length = 780 Score = 45.8 bits (107), Expect = 1e-04 Identities = 81/400 (20%), Positives = 153/400 (38%), Gaps = 28/400 (7%) Query: 256 MKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEG 315 M + +WK T + +KK+RK+ E ++ R SD+ DS D EGE + Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKE----QEEKAEIKRLKNSDDRDSKRDSLEEGELRDH 56 Query: 316 -LEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDK 374 +E T R D ++ G+ED K + KRK + + ++K Sbjct: 57 CMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEK 116 Query: 375 QKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPKQTADFLQE 434 +++ +R + Q K R +E + + + + G L + + L+ Sbjct: 117 EREHERRKRHREEQD-----KARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLER 171 Query: 435 YVTNKTKKTEELRKTVE--DLDGLIHQIYRDQDLTQEIAMEH------FVKKVEAAHCAA 486 + K E+ ++ E + + + ++++ +E++ H + KV+A+H + Sbjct: 172 KRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSR 231 Query: 487 CDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGE 546 P + + K + + M E+ S L + I +++ + E Sbjct: 232 SPPRPPRERFELGDGRKPVKEEK----MEERDLLSDL---QDISDSERKTSSAESSSAES 284 Query: 547 NPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPP 606 ++ EEE+E+EE EG +E + E E E + E + VS Sbjct: 285 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEE-EEEEEETGSNSEEASEQSAEEVSEEEMS 343 Query: 607 PPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP 646 EE E L+ + + G E +EE G G P Sbjct: 344 EDEERENENHLLV--VPESRFDRDSGESEEAEEEVGEGTP 381 >gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo sapiens] Length = 1130 Score = 45.4 bits (106), Expect = 2e-04 Identities = 30/81 (37%), Positives = 40/81 (49%), Gaps = 6/81 (7%) Query: 540 ERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAG-ISEGAEGVPAQPP-VPPEPAP 597 E + + E + EEE E+EE E +++ G A G + EGA P PP +PP +P Sbjct: 933 EEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESP 992 Query: 598 GAVSPPPPPPP----EEEEEG 614 V P P P P E EE G Sbjct: 993 PKVQPEPEPEPGLLLEVEEPG 1013 Score = 36.2 bits (82), Expect = 0.096 Identities = 26/65 (40%), Positives = 27/65 (41%), Gaps = 16/65 (24%) Query: 587 AQPPVP----PEPAPGAVSP-PPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEG 641 A PPVP PE P A P PPPPPP G V L P V + G Sbjct: 819 ASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTL-----------PPPQLVPEGTPG 867 Query: 642 GGGAP 646 GGG P Sbjct: 868 GGGPP 872 Score = 33.5 bits (75), Expect = 0.62 Identities = 24/62 (38%), Positives = 29/62 (46%), Gaps = 6/62 (9%) Query: 582 AEGVPAQPPVPPEPAPGAVS-PPPPPPPEEEEEGAVPLLGGALQRQIR--GIPGLDVEDD 638 A G PP PP P PG V+ PPP PE G P AL+ + I D E++ Sbjct: 835 APGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGP---PALEEDLTVININSSDEEEE 891 Query: 639 EE 640 EE Sbjct: 892 EE 893 Score = 32.7 bits (73), Expect = 1.1 Identities = 27/108 (25%), Positives = 55/108 (50%), Gaps = 6/108 (5%) Query: 282 GSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGRE 341 G+P A D + + + +DE E E E E E E+ + E+EE +E+ E Sbjct: 864 GTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFE-EEEEDEEEYFE 922 Query: 342 EGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQF 389 E +E+ E+ ++E G+ L+ ++ +D++++ + + VE ++F Sbjct: 923 EEEEEEEEFEEEFEEEEGE----LEEEEEEEDEEEEEELEE-VEDLEF 965 >gi|158420731 chromodomain helicase DNA binding protein 3 isoform 3 [Homo sapiens] Length = 2059 Score = 45.4 bits (106), Expect = 2e-04 Identities = 30/98 (30%), Positives = 43/98 (43%), Gaps = 12/98 (12%) Query: 540 ERYLKGENPFTDSPEEEKEQEEAEGGALD------EGAQGEAAGISEGAE-----GVPAQ 588 E + E + +E+E+EE E D EG G G G + G Sbjct: 14 EMVVSEEEEEEEEEGDEEEEEEVEAADEDDEEDDDEGVLGRGPGHDRGRDRHSPPGCHLF 73 Query: 589 PPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQRQ 626 PP PP P P PPPPPPP++++ +P G +R+ Sbjct: 74 PPPPPPPPP-LPPPPPPPPPDKDDIRLLPSALGVKKRK 110 Score = 31.2 bits (69), Expect = 3.1 Identities = 29/107 (27%), Positives = 42/107 (39%), Gaps = 10/107 (9%) Query: 511 RRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEG 570 R L+ +++ K + +IL K R NPF S A A+ Sbjct: 229 RPLIAKKNPKIPMSKMMTILGAKW------REFSANNPFKGSAAAVAAAAAAAAAAV--- 279 Query: 571 AQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVP 617 A+ +A +S P+ PP P P P A PPP + +EG P Sbjct: 280 AEQVSAAVSSATPIAPSGPPALP-PPPAADIQPPPIRRAKTKEGKGP 325 >gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform 2 [Homo sapiens] Length = 782 Score = 45.4 bits (106), Expect = 2e-04 Identities = 84/407 (20%), Positives = 161/407 (39%), Gaps = 40/407 (9%) Query: 256 MKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEG 315 M + +WK T + +KK+RK+ E ++ R SD+ DS D EGE + Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKE----QEEKAEIKRLKNSDDRDSKRDSLEEGELRDH 56 Query: 316 -LEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTT----QDENGQTKRK-----L 365 +E T R D ++ G+ED K + +DE + KR+ Sbjct: 57 RMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSA 116 Query: 366 QAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGTKLP 425 + GK ++ K+K+R+ +R + K R +E + + +EH + +L Sbjct: 117 EGGKHARVKEKEREHERRKRHRE---EQDKARREWERQKRREMA----REHSRRERDRLE 169 Query: 426 KQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEH------FVKKV 479 + +E K ++ ++ ++ ++ + + ++++ +E++ H + KV Sbjct: 170 QLERKRERE---RKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKV 226 Query: 480 EAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKL 539 +A+H + P + + K + + M E+ S L + I +++ + Sbjct: 227 KASHWSRSPPRPPRERFELGDGRKPVKEEK----MEERDLLSDL---QDISDSERKTSSA 279 Query: 540 ERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGA 599 E ++ EEE+E+EE EG +E + E E E + E + Sbjct: 280 ESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE-EEEEEETGSNSEEASEQSAEE 338 Query: 600 VSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP 646 VS EE E L+ + + G E +EE G G P Sbjct: 339 VSEEEMSEDEERENENHLLV--VPESRFDRDSGESEEAEEEVGEGTP 383 >gi|4507353 TBP-associated factor 15 isoform 2 [Homo sapiens] Length = 589 Score = 44.3 bits (103), Expect = 4e-04 Identities = 58/228 (25%), Positives = 87/228 (38%), Gaps = 25/228 (10%) Query: 28 DYGYGTWNSGTNRGYEGYGY--GYGYGQDNTTNYGYGMATSHSWEMPSSDTNANTSASGS 85 D G + G + Y YG GYGQ + + GYG T S+ + S+ G Sbjct: 3 DSGSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSY----GQNYSGYSSYGQ 58 Query: 86 ASADSVLSRINQR---LDMVPHLETDMMQG-GVYGSGGERYDSYESCDSRAVLSERDLY- 140 + + S NQ+ P+ Q GS G R SY+ D ++D Y Sbjct: 59 SYSQSYGGYENQKQSSYSQQPYNNQGQQQNMESSGSQGGRAPSYDQPD----YGQQDSYD 114 Query: 141 -RSGYDYSELDPEMEMAYEGQYDAYRDQFRMRGNDTFGPRAQGWARDARSGRPMASGYGR 199 +SGYD + + + Y+ Q+D+Y + ++ + + ++ + R S YG Sbjct: 115 QQSGYDQHQGSYDEQSNYDQQHDSY-----SQNQQSYHSQRENYSHHTQDDRRDVSRYG- 168 Query: 200 MWEDPMGARGQCMSGASRLPSLFSQNIIPEYGMFQGMRGGGAFPGGSR 247 ED G G G R P G G RGG GG R Sbjct: 169 --EDNRGYGGSQGGGRGR-GGYDKDGRGPMTGSSGGDRGGFKNFGGHR 213 >gi|21327701 TBP-associated factor 15 isoform 1 [Homo sapiens] Length = 592 Score = 44.3 bits (103), Expect = 4e-04 Identities = 59/227 (25%), Positives = 88/227 (38%), Gaps = 20/227 (8%) Query: 28 DYGYGTWNSGTNRGYEGYGY--GYGYGQDNTTNYGYGMATSHSW-EMPSSDTNANTSASG 84 D G + G + Y YG GYGQ + + GYG T S+ + S ++ S SG Sbjct: 3 DSGSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYGQNYSGYSSYGQSQSG 62 Query: 85 -SASADSVLSRINQRLDMVPHLETDMMQG-GVYGSGGERYDSYESCDSRAVLSERDLY-- 140 S S ++ P+ Q GS G R SY+ D ++D Y Sbjct: 63 YSQSYGGYENQKQSSYSQQPYNNQGQQQNMESSGSQGGRAPSYDQPD----YGQQDSYDQ 118 Query: 141 RSGYDYSELDPEMEMAYEGQYDAYRDQFRMRGNDTFGPRAQGWARDARSGRPMASGYGRM 200 +SGYD + + + Y+ Q+D+Y + ++ + + ++ + R S YG Sbjct: 119 QSGYDQHQGSYDEQSNYDQQHDSY-----SQNQQSYHSQRENYSHHTQDDRRDVSRYG-- 171 Query: 201 WEDPMGARGQCMSGASRLPSLFSQNIIPEYGMFQGMRGGGAFPGGSR 247 ED G G G R P G G RGG GG R Sbjct: 172 -EDNRGYGGSQGGGRGR-GGYDKDGRGPMTGSSGGDRGGFKNFGGHR 216 >gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sapiens] Length = 2715 Score = 44.3 bits (103), Expect = 4e-04 Identities = 39/120 (32%), Positives = 47/120 (39%), Gaps = 31/120 (25%) Query: 544 KGENPFTDSPEEEKEQEE--AEGGALDEGAQGE---AAGISEGAEGVP------------ 586 K E D EE+KE+EE EG +E A E A E A+ P Sbjct: 356 KQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPSPPP 415 Query: 587 -------------AQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGL 633 PP PP P SPPPPP EE+EE P++ R+ RG P L Sbjct: 416 PLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQEESPPPVVPATCSRK-RGRPPL 474 Score = 30.0 bits (66), Expect = 6.9 Identities = 12/24 (50%), Positives = 13/24 (54%) Query: 585 VPAQPPVPPEPAPGAVSPPPPPPP 608 + PPVP EPAP P P PP Sbjct: 567 ITTSPPVPQEPAPVPSPPRAPTPP 590 >gi|83716024 kinesin family member 21B [Homo sapiens] Length = 1624 Score = 44.3 bits (103), Expect = 4e-04 Identities = 69/355 (19%), Positives = 127/355 (35%), Gaps = 23/355 (6%) Query: 240 GAFPGGSRFGFGFGNGMKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDN 299 GA P FG + M+ + R KKK+ +Q E ++ R Sbjct: 518 GASPAAPAFGGSPASSMEDASEVIRRAKQDLERLKKKEVRQRRKSPEKEAFKKRAKLQQE 577 Query: 300 SDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENG 359 + + DE E E + + E+ R D +++ G E+ + DPE+ + Q + Sbjct: 578 NSEETDENEAEEEEEERDESGCEEEEGREDEDEDSGSEESLVDSDSDPEEKEVNFQADLA 637 Query: 360 QTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKY 419 +++ +K D+ + QR + Q+ +E L +K + Sbjct: 638 DLTCEIEIKQKLIDELENSQRRLQTLKHQY------------EEKLILLQNKIRDTQLER 685 Query: 420 VGTKLPKQTADFLQEYVTNKTKKTEE--LRKTVEDLDGL-IHQIYRDQDLTQEIAMEHFV 476 T + E NK K E LR+ DL L Q + L + E + Sbjct: 686 DRVLQNLSTMECYTEEKANKIKADYEKRLREMNRDLQKLQAAQKEHARLLKNQSRYEREL 745 Query: 477 KKVEA--AHCAACDLFIPMQFGIIQKHLKTMDHNRNRRL--MMEQSKKSSLMVARSILNN 532 KK++A A + + Q Q+ + ++ RNR + + ++ ++ + Sbjct: 746 KKLQAEVAEMKKAKVALMKQMREEQQRRRLVETKRNREIAQLKKEQRRQEFQIRALESQK 805 Query: 533 KLISKKLERYLKGENPFTDSPEEEKEQEEAEGG----ALDEGAQGEAAGISEGAE 583 + L R + + + E+ G LD GA+ A+ S AE Sbjct: 806 RQQEMVLRRKTQEVSALRRLAKPMSERVAGRAGLKPPMLDSGAEVSASTTSSEAE 860 >gi|23503317 coiled-coil domain containing 96 [Homo sapiens] Length = 555 Score = 44.3 bits (103), Expect = 4e-04 Identities = 45/114 (39%), Positives = 56/114 (49%), Gaps = 17/114 (14%) Query: 550 TDSPEEEKEQEEAEGG-ALDEGAQ-------GEAAG-ISEGAEGVPAQP-PVPPEPAP-G 598 ++ EEE+EQ ++GG A DE A+ EAAG G G PA+P P P EPA G Sbjct: 45 SEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVG 104 Query: 599 AVSPPPPPP---PE--EEEEGAVPLLGGALQRQIRGIPGLDV-EDDEEGGGGAP 646 A P P P PE E E GA L A +++R L + DEE AP Sbjct: 105 AEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAP 158 Score = 31.2 bits (69), Expect = 3.1 Identities = 26/77 (33%), Positives = 30/77 (38%), Gaps = 7/77 (9%) Query: 569 EGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQRQIR 628 EG GE+ + PP PEP G + P EEEEE A G A Q Sbjct: 14 EGGDGESLAARPSKIKASSGPPTSPEP--GELE---SEPEEEEEEQAASQGGTAADEQAE 68 Query: 629 GIPGLDVED--DEEGGG 643 GL + EEG G Sbjct: 69 APKGLTAAEAAGEEGPG 85 >gi|39812378 RAN binding protein 9 [Homo sapiens] Length = 729 Score = 43.9 bits (102), Expect = 5e-04 Identities = 30/82 (36%), Positives = 33/82 (40%), Gaps = 9/82 (10%) Query: 565 GALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQ 624 G+ GA GE G+ A + PP PP PA A PPPPPPP A P G Sbjct: 49 GSPGGGAGGE--GLGAAAAALLLHPPPPPPPATAAPPPPPPPPP-PPASAAAPASGPPAP 105 Query: 625 RQIRGIPGLDVEDDEEGGGGAP 646 PGL GG P Sbjct: 106 ------PGLAAGPGPAGGAPTP 121 Score = 30.4 bits (67), Expect = 5.3 Identities = 23/67 (34%), Positives = 24/67 (35%), Gaps = 9/67 (13%) Query: 564 GGALDEGAQGEAAGI--------SEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGA 615 GGA EG AA + P PP PP PA A PP P G Sbjct: 53 GGAGGEGLGAAAAALLLHPPPPPPPATAAPPPPPPPPPPPASAAAPASGPPAPPGLAAGP 112 Query: 616 VPLLGGA 622 P GGA Sbjct: 113 GP-AGGA 118 >gi|21361639 DIPB protein [Homo sapiens] Length = 344 Score = 43.9 bits (102), Expect = 5e-04 Identities = 42/201 (20%), Positives = 82/201 (40%), Gaps = 39/201 (19%) Query: 280 QGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGE-DEEGKED 338 +G +E + K + + +++ G E E+ E E E E + E DEE +ED Sbjct: 74 EGAGKEEAEVKVEQ-----EREIESEAGEESESEEESESEEESETEEESEDESDEESEED 128 Query: 339 GREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQ-DKQKKRQRDRMVER----------- 386 EE +++ E A E G+++ + + +S+ D + + + +R+ +R Sbjct: 129 SEEEMEDEQESEAEEDNQEEGESEAEGETEAESEFDPEIEMEAERVAKRKCPDHGLDLST 188 Query: 387 -----IQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVG----------------TKLP 425 Q +C LC ++ S LD F + K G + P Sbjct: 189 YCQEDRQLICVLCPVIGAHQGHQLSTLDEAFEELRSKDSGGLKAAMIELVERLKFKSSDP 248 Query: 426 KQTADFLQEYVTNKTKKTEEL 446 K T D ++ ++ + KK +++ Sbjct: 249 KVTRDQMKMFIQQEFKKVQKV 269 >gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1 [Homo sapiens] Length = 651 Score = 43.9 bits (102), Expect = 5e-04 Identities = 74/393 (18%), Positives = 139/393 (35%), Gaps = 65/393 (16%) Query: 254 NGMKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEAT 313 N K + +T D + KK S D D+K N D+ + + T Sbjct: 271 NNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDT 330 Query: 314 EGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTK------RKLQA 367 E + K R D + ++ K+ +++ K+D +K +T E+G K R L+ Sbjct: 331 ESTDAESGDSKDERKDTKKDK-KKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKK 389 Query: 368 GKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPKQ 427 K+ DK+K ++ + T E E+ S K K+ K T K Sbjct: 390 ASKNDDKKKDAKK-------------ITFSTDSESELESKESQKDEKKDKKDSKTDNKK- 435 Query: 428 TADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVEAAHCAAC 487 K EE + G + +D+ ++ + + KK + + Sbjct: 436 -----------SVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAEST 484 Query: 488 DLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGEN 547 ++ ++ +KH K + +++ + + ++K + + K +KG + Sbjct: 485 EMESDLELKKDKKHSK--EKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSD 542 Query: 548 PFTD----SPEEEKEQEEAEGGALDEGAQG----------------EAAGISEGAEGVPA 587 ++ P +K+ +E++G + + +G G VP Sbjct: 543 TESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPP 602 Query: 588 QPPVPPEPA--PGAVSPP---------PPPPPE 609 PP PA P SP PPPPP+ Sbjct: 603 SREKPPLPACEPSLPSPKVRRLCWCKMPPPPPK 635 >gi|7706687 Enah/Vasp-like [Homo sapiens] Length = 418 Score = 43.9 bits (102), Expect = 5e-04 Identities = 28/104 (26%), Positives = 38/104 (36%), Gaps = 18/104 (17%) Query: 554 EEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPP------ 607 E + + A G L G AA G P PP P P P +PPPPPP Sbjct: 153 ESLERRTSATGPILPPGHPSSAASAPVSCSGPPPPPPPPVPPPPTGATPPPPPPLPAGGA 212 Query: 608 -----PEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP 646 E G + GA R+++ ++ GG +P Sbjct: 213 QGSSHDESSMSGLAAAIAGAKLRRVQ-------RPEDASGGSSP 249 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.311 0.131 0.386 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 29,697,832 Number of Sequences: 37866 Number of extensions: 1752108 Number of successful extensions: 33680 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 663 Number of HSP's successfully gapped in prelim test: 926 Number of HSP's that attempted gapping in prelim test: 17101 Number of HSP's gapped (non-prelim): 11685 length of query: 646 length of database: 18,247,518 effective HSP length: 109 effective length of query: 537 effective length of database: 14,120,124 effective search space: 7582506588 effective search space used: 7582506588 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.7 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.