Guide to the Human Genome
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Search of human proteins with 48928017

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|48928017 nuclear factor of kappa light polypeptide gene
enhancer in B-cells inhibitor, beta isoform b [Homo sapiens]
         (306 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|48928017 nuclear factor of kappa light polypeptide gene enhan...   627   e-180
gi|21361135 nuclear factor of kappa light polypeptide gene enhan...   497   e-141
gi|71274109 nuclear factor of kappa light polypeptide gene enhan...   113   2e-25
gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]                     107   1e-23
gi|117320531 nuclear factor of kappa light polypeptide gene enha...   102   6e-22
gi|117320540 nuclear factor of kappa light polypeptide gene enha...   102   6e-22
gi|117320527 nuclear factor of kappa light polypeptide gene enha...   102   6e-22
gi|10092619 nuclear factor of kappa light polypeptide gene enhan...    98   1e-20
gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]           82   6e-16
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         75   7e-14
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        73   3e-13
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         73   3e-13
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         73   3e-13
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        72   6e-13
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         72   6e-13
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         72   6e-13
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         72   6e-13
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         72   6e-13
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2...    71   1e-12
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1...    71   1e-12
gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3...    71   1e-12
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    70   2e-12
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                   70   2e-12
gi|52486251 phospholipase A2, group VI isoform b [Homo sapiens]        69   4e-12
gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens]        69   4e-12
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]         67   3e-11
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]         66   4e-11
gi|55770876 notch4 preproprotein [Homo sapiens]                        65   6e-11
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]         65   6e-11
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]         65   6e-11

>gi|48928017 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, beta isoform b [Homo sapiens]
          Length = 306

 Score =  627 bits (1617), Expect = e-180
 Identities = 306/306 (100%), Positives = 306/306 (100%)

Query: 1   MNGATAAWAPWVRTQRPPEDLGWARSWARGCRGLPSSSATSLRMGTRFSAGTEYMDLQND 60
           MNGATAAWAPWVRTQRPPEDLGWARSWARGCRGLPSSSATSLRMGTRFSAGTEYMDLQND
Sbjct: 1   MNGATAAWAPWVRTQRPPEDLGWARSWARGCRGLPSSSATSLRMGTRFSAGTEYMDLQND 60

Query: 61  LGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPR 120
           LGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPR
Sbjct: 61  LGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPR 120

Query: 121 RPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLH 180
           RPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLH
Sbjct: 121 RPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLH 180

Query: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240
           VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY
Sbjct: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240

Query: 241 GGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGS 300
           GGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGS
Sbjct: 241 GGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGS 300

Query: 301 PAGGSG 306
           PAGGSG
Sbjct: 301 PAGGSG 306


>gi|21361135 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, beta isoform a [Homo sapiens]
          Length = 356

 Score =  497 bits (1279), Expect = e-141
 Identities = 244/244 (100%), Positives = 244/244 (100%)

Query: 48  FSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGA 107
           FSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGA
Sbjct: 80  FSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGA 139

Query: 108 HACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQ 167
           HACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQ
Sbjct: 140 HACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQ 199

Query: 168 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL 227
           LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL
Sbjct: 200 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL 259

Query: 228 LLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDS 287
           LLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDS
Sbjct: 260 LLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDS 319

Query: 288 GDEG 291
           GDEG
Sbjct: 320 GDEG 323



 Score = 34.7 bits (78), Expect = 0.11
 Identities = 39/143 (27%), Positives = 52/143 (36%), Gaps = 25/143 (17%)

Query: 174 EGHTPLHVAVIHKDVEMVRLLR--DAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231
           +G T LH+AVIH+    +  L    AG +    +   G++ LHLA        +E L  A
Sbjct: 57  DGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 116

Query: 232 GANPAARMYGGRTPL-----------GSAMLRPNPILARLLRAHGAPE-------PEGED 273
           GA        G T L             A+L+P P      R   AP+           D
Sbjct: 117 GAGLCVAERRGHTALHLACRVGAHACARALLQPRP-----RRPREAPDTYLAQGPDRTPD 171

Query: 274 EKSGPCSSSSDSDSGDEGVSQEE 296
               P +   DSD   E    EE
Sbjct: 172 TNHTPVALYPDSDLEKEEEESEE 194


>gi|71274109 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, epsilon [Homo sapiens]
          Length = 500

 Score =  113 bits (282), Expect = 2e-25
 Identities = 72/194 (37%), Positives = 99/194 (51%), Gaps = 37/194 (19%)

Query: 53  EYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACAR 112
           E +D+QN+L QTALHLA  L +   V  L   GA   + +R G TALH+AC+    ACAR
Sbjct: 285 EVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACAR 344

Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
            LL+ RP   R                T+H+                      L L+ +N
Sbjct: 345 CLLEGRPEPGR---------------GTSHS----------------------LDLQLQN 367

Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232
           ++G   LH+A + K+  ++ LL   GAD+D  E T G++ LHLAVE Q   +++ LL+AG
Sbjct: 368 WQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAG 427

Query: 233 ANPAARMYGGRTPL 246
           A   ARM  G TPL
Sbjct: 428 AQVDARMLNGCTPL 441



 Score = 35.8 bits (81), Expect = 0.049
 Identities = 36/110 (32%), Positives = 50/110 (45%), Gaps = 11/110 (10%)

Query: 167 QLEAENY---EGHTPLHVAVIHKDVEMV----RLLRDAGADLDKPEPTCGRSPLHLAVEA 219
           QLEA  Y   +G T +H+AVIH+   ++     LL     D+        ++ LHLAV  
Sbjct: 248 QLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQN---NLYQTALHLAVHL 304

Query: 220 QAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEP 269
                +  L+  GA+ A +   G T L  A  R +   AR L   G PEP
Sbjct: 305 DQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCL-LEGRPEP 353


>gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]
          Length = 454

 Score =  107 bits (268), Expect = 1e-23
 Identities = 83/224 (37%), Positives = 102/224 (45%), Gaps = 43/224 (19%)

Query: 43  RMGTRFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLA 102
           R+   F  G   +D+ N+L QT LHLA I    S V  L  AGA     +R G TA HLA
Sbjct: 153 RLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLA 212

Query: 103 CRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEE 162
           C   +  C RALL         AP T                                  
Sbjct: 213 CEHRSPTCLRALLDSA------APGT---------------------------------- 232

Query: 163 DWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAA 222
              L LEA NY+G T LHVAV  +  E V+LL + GAD+D  +   GRSPL  AVE  + 
Sbjct: 233 ---LDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSL 289

Query: 223 DVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
            +++LLL+ GAN  A+MY G + L SA  R    L R L   GA
Sbjct: 290 SMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGA 333



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 34/98 (34%), Positives = 49/98 (50%), Gaps = 5/98 (5%)

Query: 174 EGHTPLHVAVIHKDV----EMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLL 229
           +G TPLH+AV+  ++     +V L +  G +LD       ++PLHLAV      V+ LL+
Sbjct: 134 DGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYN-NLRQTPLHLAVITTLPSVVRLLV 192

Query: 230 RAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
            AGA+P A    G+T    A    +P   R L    AP
Sbjct: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAP 230


>gi|117320531 nuclear factor of kappa light polypeptide gene
           enhancer in B-cells 2 isoform a [Homo sapiens]
          Length = 900

 Score =  102 bits (253), Expect = 6e-22
 Identities = 85/248 (34%), Positives = 111/248 (44%), Gaps = 47/248 (18%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHA--CAR 112
           ++L N L QT LHLA I G+TS V  L   GA   + +R G +A+HLA R GA A    R
Sbjct: 520 VNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLR 579

Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
           ALLQ                G    P   H P                           +
Sbjct: 580 ALLQ---------------SGAPAVPQLLHMP---------------------------D 597

Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAAD-VLELLLRA 231
           +EG  P+H+AV  +  E + LL D+GA+++  E   GR+ LHLA E +    V  L+ + 
Sbjct: 598 FEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKL 657

Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSS--SSDSDSGD 289
            AN  AR + G TPL  A     P L RLL   GA      +E   P  S  +SDSDS  
Sbjct: 658 RANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDS 717

Query: 290 EGVSQEER 297
           EG  ++ R
Sbjct: 718 EGPEKDTR 725



 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 7/107 (6%)

Query: 168 LEAENYEGHTPLHVAVIHKD---VEMVRLLRDAGADLDKPEPT--CGRSPLHLAVEAQAA 222
           L A++  G TPLH+A+IH     +E +  +     DL     T    ++PLHLAV     
Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540

Query: 223 DVLELLLRAGANPAARMYGGRTPLGSAML--RPNPILARLLRAHGAP 267
            V+  LLR GA+PA     G + +  A+      P L R L   GAP
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP 587



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 75/286 (26%), Positives = 105/286 (36%), Gaps = 58/286 (20%)

Query: 50  AGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA-AGAGLCVAERRGHTALHLACRVGAH 108
           +G E    +   G+TALHLA  + E   V  L     A +      G+T LHLA  +G  
Sbjct: 622 SGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYP 681

Query: 109 ACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH--TPVALYPDSDLEKEEEESEEDWKL 166
              R LL+                G D   +      P+   P SD + + E  E+D + 
Sbjct: 682 TLTRLLLK---------------AGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTR- 725

Query: 167 QLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPL--HLAVEAQAADV 224
                ++ GHTPL +       ++  LL +A  +  +P P    SP    L++   A   
Sbjct: 726 ----SSFRGHTPLDLTC---STKVKTLLLNAAQNTMEP-PLTPPSPAGPGLSLGDTALQN 777

Query: 225 LELLL--------------RAGANPAARMYGGRTPLGSAMLRPNPI----LARLLRA--- 263
           LE LL              R G       Y   T    ++LR   +    LA LL A   
Sbjct: 778 LEQLLDGPEAQGSWAELAERLGLRSLVDTYRQTTSPSGSLLRSYELAGGDLAGLLEALSD 837

Query: 264 HGAPE-------PEGEDEKSGPCSSSSDSDSGDEGVSQE-ERQGSP 301
            G  E       PE  D+         DS  G + V QE E+ G P
Sbjct: 838 MGLEEGVRLLRGPETRDKLPSTAEVKEDSAYGSQSVEQEAEKLGPP 883


>gi|117320540 nuclear factor of kappa light polypeptide gene
           enhancer in B-cells 2 isoform b [Homo sapiens]
          Length = 899

 Score =  102 bits (253), Expect = 6e-22
 Identities = 85/248 (34%), Positives = 111/248 (44%), Gaps = 47/248 (18%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHA--CAR 112
           ++L N L QT LHLA I G+TS V  L   GA   + +R G +A+HLA R GA A    R
Sbjct: 520 VNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLR 579

Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
           ALLQ                G    P   H P                           +
Sbjct: 580 ALLQ---------------SGAPAVPQLLHMP---------------------------D 597

Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAAD-VLELLLRA 231
           +EG  P+H+AV  +  E + LL D+GA+++  E   GR+ LHLA E +    V  L+ + 
Sbjct: 598 FEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKL 657

Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSS--SSDSDSGD 289
            AN  AR + G TPL  A     P L RLL   GA      +E   P  S  +SDSDS  
Sbjct: 658 RANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDS 717

Query: 290 EGVSQEER 297
           EG  ++ R
Sbjct: 718 EGPEKDTR 725



 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 7/107 (6%)

Query: 168 LEAENYEGHTPLHVAVIHKD---VEMVRLLRDAGADLDKPEPT--CGRSPLHLAVEAQAA 222
           L A++  G TPLH+A+IH     +E +  +     DL     T    ++PLHLAV     
Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540

Query: 223 DVLELLLRAGANPAARMYGGRTPLGSAML--RPNPILARLLRAHGAP 267
            V+  LLR GA+PA     G + +  A+      P L R L   GAP
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP 587



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 76/286 (26%), Positives = 105/286 (36%), Gaps = 59/286 (20%)

Query: 50  AGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA-AGAGLCVAERRGHTALHLACRVGAH 108
           +G E    +   G+TALHLA  + E   V  L     A +      G+T LHLA  +G  
Sbjct: 622 SGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYP 681

Query: 109 ACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH--TPVALYPDSDLEKEEEESEEDWKL 166
              R LL+                G D   +      P+   P SD + + E  E+D + 
Sbjct: 682 TLTRLLLK---------------AGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTR- 725

Query: 167 QLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPL--HLAVEAQAADV 224
                ++ GHTPL +       ++  LL +A  +  +P P    SP    L++   A   
Sbjct: 726 ----SSFRGHTPLDLTC---STKVKTLLLNAAQNTMEP-PLTPPSPAGPGLSLGDTALQN 777

Query: 225 LELLL--------------RAGANPAARMYGGRTPLGSAMLRPNPI----LARLLRA--- 263
           LE LL              R G       Y   T    ++LR   +    LA LL A   
Sbjct: 778 LEQLLDGPEAQGSWAELAERLGLRSLVDTYRQTTSPSGSLLRSYELAGGDLAGLLEALSD 837

Query: 264 HGAPE-------PEGEDEKSGPCSSSSDSDSGDEGVSQE-ERQGSP 301
            G  E       PE  D K        DS  G + V QE E+ G P
Sbjct: 838 MGLEEGVRLLRGPETRD-KLPSTEVKEDSAYGSQSVEQEAEKLGPP 882


>gi|117320527 nuclear factor of kappa light polypeptide gene
           enhancer in B-cells 2 isoform b [Homo sapiens]
          Length = 899

 Score =  102 bits (253), Expect = 6e-22
 Identities = 85/248 (34%), Positives = 111/248 (44%), Gaps = 47/248 (18%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHA--CAR 112
           ++L N L QT LHLA I G+TS V  L   GA   + +R G +A+HLA R GA A    R
Sbjct: 520 VNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLR 579

Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
           ALLQ                G    P   H P                           +
Sbjct: 580 ALLQ---------------SGAPAVPQLLHMP---------------------------D 597

Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAAD-VLELLLRA 231
           +EG  P+H+AV  +  E + LL D+GA+++  E   GR+ LHLA E +    V  L+ + 
Sbjct: 598 FEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKL 657

Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSS--SSDSDSGD 289
            AN  AR + G TPL  A     P L RLL   GA      +E   P  S  +SDSDS  
Sbjct: 658 RANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDS 717

Query: 290 EGVSQEER 297
           EG  ++ R
Sbjct: 718 EGPEKDTR 725



 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 7/107 (6%)

Query: 168 LEAENYEGHTPLHVAVIHKD---VEMVRLLRDAGADLDKPEPT--CGRSPLHLAVEAQAA 222
           L A++  G TPLH+A+IH     +E +  +     DL     T    ++PLHLAV     
Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540

Query: 223 DVLELLLRAGANPAARMYGGRTPLGSAML--RPNPILARLLRAHGAP 267
            V+  LLR GA+PA     G + +  A+      P L R L   GAP
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP 587



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 76/286 (26%), Positives = 105/286 (36%), Gaps = 59/286 (20%)

Query: 50  AGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA-AGAGLCVAERRGHTALHLACRVGAH 108
           +G E    +   G+TALHLA  + E   V  L     A +      G+T LHLA  +G  
Sbjct: 622 SGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYP 681

Query: 109 ACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH--TPVALYPDSDLEKEEEESEEDWKL 166
              R LL+                G D   +      P+   P SD + + E  E+D + 
Sbjct: 682 TLTRLLLK---------------AGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTR- 725

Query: 167 QLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPL--HLAVEAQAADV 224
                ++ GHTPL +       ++  LL +A  +  +P P    SP    L++   A   
Sbjct: 726 ----SSFRGHTPLDLTC---STKVKTLLLNAAQNTMEP-PLTPPSPAGPGLSLGDTALQN 777

Query: 225 LELLL--------------RAGANPAARMYGGRTPLGSAMLRPNPI----LARLLRA--- 263
           LE LL              R G       Y   T    ++LR   +    LA LL A   
Sbjct: 778 LEQLLDGPEAQGSWAELAERLGLRSLVDTYRQTTSPSGSLLRSYELAGGDLAGLLEALSD 837

Query: 264 HGAPE-------PEGEDEKSGPCSSSSDSDSGDEGVSQE-ERQGSP 301
            G  E       PE  D K        DS  G + V QE E+ G P
Sbjct: 838 MGLEEGVRLLRGPETRD-KLPSTEVKEDSAYGSQSVEQEAEKLGPP 882


>gi|10092619 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, alpha [Homo sapiens]
          Length = 317

 Score = 97.8 bits (242), Expect = 1e-20
 Identities = 78/241 (32%), Positives = 104/241 (43%), Gaps = 45/241 (18%)

Query: 54  YMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARA 113
           +++ QN+L QT LHLA I  +    E L  AG    + + RG+T LHLAC  G  A    
Sbjct: 103 FLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGV 162

Query: 114 LLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENY 173
           L Q                    TP  +                          L+A NY
Sbjct: 163 LTQSCT-----------------TPHLHSI------------------------LKATNY 181

Query: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233
            GHT LH+A IH  + +V LL   GAD++  EP  GR+ LHLAV+ Q  D++ LLL+ GA
Sbjct: 182 NGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGA 241

Query: 234 NPAARMYGGRTPL----GSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGD 289
           +     Y G +P     G    R    L +L   +    PE EDE+S    S     + D
Sbjct: 242 DVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTED 301

Query: 290 E 290
           E
Sbjct: 302 E 302



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 32/95 (33%), Positives = 50/95 (52%), Gaps = 6/95 (6%)

Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEM-VRLLRDAGADLD--KPEPTCGRS 211
           +E     E WK QL  +   G + LH+A+IH++  + + ++R    DL     +    ++
Sbjct: 57  QEVPRGSEPWKQQLTED---GDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQT 113

Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 246
           PLHLAV     ++ E LL AG +P  R + G TPL
Sbjct: 114 PLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPL 148


>gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]
          Length = 969

 Score = 82.0 bits (201), Expect = 6e-16
 Identities = 73/241 (30%), Positives = 103/241 (42%), Gaps = 45/241 (18%)

Query: 53  EYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACAR 112
           + ++++NDL QT LHLA I  +   VE L  AGA L + +R G++ LHLA + G      
Sbjct: 574 DIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLS 633

Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
            LL+                         H   AL                    L+  N
Sbjct: 634 ILLK-------------------------HKKAALL-------------------LDHPN 649

Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE-LLLRA 231
            +G   +H+A++   +  + LL  AGAD++  E   GR+ LHLAVE     +   LLL  
Sbjct: 650 GDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEG 709

Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEG 291
            A+  +  Y G TPL  A  R +  LA LL+A GA       E       S ++   DEG
Sbjct: 710 DAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEG 769

Query: 292 V 292
           V
Sbjct: 770 V 770



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 25/69 (36%), Positives = 40/69 (57%), Gaps = 5/69 (7%)

Query: 171 ENYEGHTPLHVAVIHKDVEMVRLLRDAGA-----DLDKPEPTCGRSPLHLAVEAQAADVL 225
           ++  G + LH+A+IH   ++VR L +  +     D+        ++PLHLAV  +  DV+
Sbjct: 540 QDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVV 599

Query: 226 ELLLRAGAN 234
           E LLRAGA+
Sbjct: 600 EDLLRAGAD 608


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 70/227 (30%), Positives = 96/227 (42%), Gaps = 26/227 (11%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T +H+AA +G  + V +L   GA       RG TALH+A R G     R L+Q   + 
Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 492

Query: 122 PREAPD------------------TYLAQG--PDRTPDTNHTPVALYPDSDLEKEEEESE 161
             +A D                    L QG  P+    + +TP+ L   S  E  E+ + 
Sbjct: 493 EAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHL---SAREGHEDVAA 549

Query: 162 --EDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEA 219
              D    L     +G TPLHVA  +  +E+  LL    A  D    + G +PLH+A   
Sbjct: 550 FLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKS-GLTPLHVAAHY 608

Query: 220 QAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
               V  LLL  GA+P A    G TPL  A  +    +A  L  +GA
Sbjct: 609 DNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGA 655



 Score = 58.9 bits (141), Expect = 5e-09
 Identities = 54/228 (23%), Positives = 97/228 (42%), Gaps = 16/228 (7%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           +D     G TALH+A++ G+   V+ L   GA +    + G T L++A +       + L
Sbjct: 100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159

Query: 115 LQPRPRRPREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDW 164
           L     +     D +      L QG D+      + +       P   +   +++++   
Sbjct: 160 LDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAA 219

Query: 165 KL-----QLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEA 219
            L       + E+  G TPLH+A  + ++ +  LL +  A +D        +PLH+A + 
Sbjct: 220 LLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN-DITPLHVASKR 278

Query: 220 QAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
             A++++LLL  GA   A+   G TPL       +  +  +L    AP
Sbjct: 279 GNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326



 Score = 58.9 bits (141), Expect = 5e-09
 Identities = 59/225 (26%), Positives = 90/225 (40%), Gaps = 22/225 (9%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPR- 120
           G T LHL+A  G       L   GA L +  ++G T LH+A + G    A  LLQ     
Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP 591

Query: 121 --------RPREAPDTY---------LAQG--PDRTPDTNHTPVALYPDSDLEKEEEESE 161
                    P      Y         L QG  P       +TP+ +    + + +   + 
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN-QMDIATTL 650

Query: 162 EDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQA 221
            ++     A   +G   +H+A     V+MV LL    A+++    + G +PLHLA +   
Sbjct: 651 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS-GLTPLHLAAQEDR 709

Query: 222 ADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
            +V E+L+  GA+  A+   G TPL       N  +   L  H A
Sbjct: 710 VNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSA 754



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 49/188 (26%), Positives = 77/188 (40%), Gaps = 15/188 (7%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH+AA   +      L   GA      R+G  ++HLA + G H    +LL  R   
Sbjct: 631 GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEG-HVDMVSLLLGRNAN 689

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
              +  + L            TP+ L    D     E         ++A+   G+TPLHV
Sbjct: 690 VNLSNKSGL------------TPLHLAAQEDRVNVAEVLVNQGA-HVDAQTKMGYTPLHV 736

Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
              + ++++V  L    A ++      G +PLH A +     ++ +LL+  A+P      
Sbjct: 737 GCHYGNIKIVNFLLQHSAKVNAKTKN-GYTPLHQAAQQGHTHIINVLLQNNASPNELTVN 795

Query: 242 GRTPLGSA 249
           G T LG A
Sbjct: 796 GNTALGIA 803



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 59/232 (25%), Positives = 87/232 (37%), Gaps = 26/232 (11%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           +++ N  G  ALHLA+  G    V +L    A +  A ++G+TALH+A   G     + L
Sbjct: 67  INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126

Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 174
           +        ++ + +           NH  V  +   D    +  + ED    L     +
Sbjct: 127 VTNGANVNAQSQNGFTPL--YMAAQENHLEVVKFL-LDNGASQSLATEDGFTPLAVALQQ 183

Query: 175 GH------------------TPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSPLH 214
           GH                    LH+A    D +   LL   D  AD+   E   G +PLH
Sbjct: 184 GHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADV---ESKSGFTPLH 240

Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           +A      +V  LLL   A          TPL  A  R N  + +LL   GA
Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGA 292



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 49/205 (23%), Positives = 75/205 (36%), Gaps = 48/205 (23%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH+A        +E L   GA +      G T +H+A  +G       L+      
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM------ 453

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
                  +    P+ T                                  N  G T LH+
Sbjct: 454 -------HHGASPNTT----------------------------------NVRGETALHM 472

Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
           A      E+VR L   GA ++  +    ++PLH++     AD+++ LL+ GA+P A    
Sbjct: 473 AARSGQAEVVRYLVQDGAQVE-AKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS 531

Query: 242 GRTPLGSAMLRPNPILARLLRAHGA 266
           G TPL  +    +  +A  L  HGA
Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGA 556



 Score = 48.5 bits (114), Expect = 7e-06
 Identities = 55/223 (24%), Positives = 86/223 (38%), Gaps = 16/223 (7%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           +D +   G T LH  A  G    VE L    A +    + G + LH+A +     C + L
Sbjct: 294 IDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLL 353

Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 174
           LQ          D   A          H  VA            +   D K    A+   
Sbjct: 354 LQHNVPVDDVTNDYLTALHV--AAHCGHYKVA------------KVLLDKKANPNAKALN 399

Query: 175 GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
           G TPLH+A     ++++ LL   GA +     + G +P+H+A      +++  L+  GA+
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTES-GLTPIHVAAFMGHVNIVSQLMHHGAS 458

Query: 235 PAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDEKS 276
           P      G T L  A       + R L   GA  E + +D+++
Sbjct: 459 PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQT 501



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 51/222 (22%), Positives = 81/222 (36%), Gaps = 29/222 (13%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           D     G T LH+AA          L   GA    A + G+T LH+A +           
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAK----------- 640

Query: 116 QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-------KLQL 168
               +   +   T L  G D    T     +++  +      +E   D           +
Sbjct: 641 ----KNQMDIATTLLEYGADANAVTRQGIASVHLAA------QEGHVDMVSLLLGRNANV 690

Query: 169 EAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELL 228
              N  G TPLH+A     V +  +L + GA +D  +   G +PLH+        ++  L
Sbjct: 691 NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDA-QTKMGYTPLHVGCHYGNIKIVNFL 749

Query: 229 LRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPE 270
           L+  A   A+   G TPL  A  + +  +  +L  + A   E
Sbjct: 750 LQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 31/97 (31%), Positives = 48/97 (49%), Gaps = 1/97 (1%)

Query: 172 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231
           N  G   LH+A     VE+V  L    A++D      G + LH+A  A  A+V+++L+  
Sbjct: 71  NQNGLNALHLASKEGHVEVVSELLQREANVDAATKK-GNTALHIASLAGQAEVVKVLVTN 129

Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPE 268
           GAN  A+   G TPL  A    +  + + L  +GA +
Sbjct: 130 GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ 166



 Score = 37.7 bits (86), Expect = 0.013
 Identities = 22/62 (35%), Positives = 29/62 (46%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           ++L N  G T LHLAA     +  E L   GA +    + G+T LH+ C  G       L
Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749

Query: 115 LQ 116
           LQ
Sbjct: 750 LQ 751



 Score = 32.7 bits (73), Expect = 0.41
 Identities = 19/63 (30%), Positives = 27/63 (42%)

Query: 54  YMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARA 113
           ++D Q  +G T LH+    G    V  L    A +    + G+T LH A + G       
Sbjct: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781

Query: 114 LLQ 116
           LLQ
Sbjct: 782 LLQ 784


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 66/217 (30%), Positives = 93/217 (42%), Gaps = 27/217 (12%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           D+ N  G+TALH+AA  G+   V  L   GA +    R   T LH+A R+G     + LL
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 496

Query: 116 QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEA----- 170
           Q            ++A  PD      +TP+ +          E   +   + LEA     
Sbjct: 497 Q------------HMAH-PDAATTNGYTPLHI-------SAREGQVDVASVLLEAGAAHS 536

Query: 171 -ENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLL 229
               +G TPLHVA  +  +++ +LL    A  D      G +PLH+A       V  LLL
Sbjct: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLL 595

Query: 230 RAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
             GA+P A    G TPL  A  +    +A  L  +GA
Sbjct: 596 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 632



 Score = 68.2 bits (165), Expect = 9e-12
 Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 17/208 (8%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH++A  G+      L  AGA   +A ++G T LH+A + G+   A+ LLQ R   
Sbjct: 509 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA-- 566

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES-EEDWKLQLEAENYEGHTPLH 180
                        D       TP+ +    D +K      E+       A+N  G+TPLH
Sbjct: 567 -----------AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--GYTPLH 613

Query: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240
           +A     +++   L + GA+ +      G +PLHLA +    D++ LLL  GAN      
Sbjct: 614 IAAKKNQMQIASTLLNYGAETNIVTKQ-GVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 672

Query: 241 GGRTPLGSAMLRPNPILARLLRAHGAPE 268
            G T L  A       +A +L  HGA +
Sbjct: 673 SGLTSLHLAAQEDKVNVADILTKHGADQ 700



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 60/243 (24%), Positives = 98/243 (40%), Gaps = 38/243 (15%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           +D     G TALH+A++ G+   V+ L   GA +    + G T L++A +       + L
Sbjct: 69  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128

Query: 115 LQPRPRRPREAPDTY------LAQGPD------------------------RTPDTNHTP 144
           L+    +     D +      L QG +                        R  DT    
Sbjct: 129 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 188

Query: 145 VALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKP 204
           + L  D + + +        K+ +      G TPLH+A  + +V +  LL + GA +D  
Sbjct: 189 LLLQNDHNADVQS-------KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 241

Query: 205 EPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAH 264
               G +PLH+A +    ++++LLL  G    A+   G TPL  A    +  +  LL   
Sbjct: 242 ARN-GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 300

Query: 265 GAP 267
           GAP
Sbjct: 301 GAP 303



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 64/239 (26%), Positives = 95/239 (39%), Gaps = 30/239 (12%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           ++ Q+  G T L++AA       V+ L   GA    A   G T L +A + G +     L
Sbjct: 102 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161

Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEE-----ESEEDWKLQLE 169
           L+   +     P  ++A   D   DT    + L  D + + + +      +E  +     
Sbjct: 162 LENDTKGKVRLPALHIAARKD---DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 218

Query: 170 AENY---------------------EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 208
           A +Y                      G TPLHVA    +  MV+LL D G  +D  +   
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA-KTRD 277

Query: 209 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
           G +PLH A  +    V+ELLL  GA   AR   G +PL  A    +    + L  H AP
Sbjct: 278 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 336



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 63/234 (26%), Positives = 88/234 (37%), Gaps = 32/234 (13%)

Query: 59  NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPR 118
           N  G  ALHLAA  G    V++L   G+ +  A ++G+TALH+A   G     + L++  
Sbjct: 40  NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 99

Query: 119 PRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES--EEDWKLQLEAENYEGH 176
                ++ + +           NH  V  Y    LE    +S   ED    L     +GH
Sbjct: 100 ANINAQSQNGFTPL--YMAAQENHIDVVKYL---LENGANQSTATEDGFTPLAVALQQGH 154

Query: 177 T------------------PLHVAVIHKDVEMVRLL--RDAGADLDKP-----EPTCGRS 211
                               LH+A    D +   LL   D  AD+            G +
Sbjct: 155 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 214

Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
           PLH+A      +V  LLL  GA        G TPL  A  R N  + +LL   G
Sbjct: 215 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 268



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 63/240 (26%), Positives = 86/240 (35%), Gaps = 48/240 (20%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T +H+AA +G  + V  L   GA   V   RG TALH+A R G     R L       
Sbjct: 410 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL------- 462

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
                   L  G                                  ++A   E  TPLH+
Sbjct: 463 --------LRNGA--------------------------------LVDARAREEQTPLHI 482

Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
           A      E+V+LL    A  D    T G +PLH++      DV  +LL AGA  +     
Sbjct: 483 ASRLGKTEIVQLLLQHMAHPDAAT-TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK 541

Query: 242 GRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGSP 301
           G TPL  A    +  +A+LL    A           P   ++  D+    +   E+  SP
Sbjct: 542 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 601



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 53/192 (27%), Positives = 77/192 (40%), Gaps = 23/192 (11%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH+AA   +      L   GA   +  ++G T LHLA + G       LL      
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667

Query: 122 PREAPD----TYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT 177
                      +LA   D+    N   +       L K   + +   KL        G+T
Sbjct: 668 HMSTKSGLTSLHLAAQEDKV---NVADI-------LTKHGADQDAHTKL--------GYT 709

Query: 178 PLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAA 237
           PL VA  + +V+MV  L   GA+++      G +PLH A +     ++ +LL+ GA P A
Sbjct: 710 PLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKPNA 768

Query: 238 RMYGGRTPLGSA 249
               G T L  A
Sbjct: 769 TTANGNTALAIA 780



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 65/245 (26%), Positives = 88/245 (35%), Gaps = 48/245 (19%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGL---------------------CVAER 93
           +D +   G T LH AA  G    VE L   GA L                     CV   
Sbjct: 271 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 330

Query: 94  RGH------------TALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTN 141
             H            TALH+A   G +   + LL  R               P+      
Sbjct: 331 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR-------------ANPNARALNG 377

Query: 142 HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADL 201
            TP+ +    +  K  E   + +   ++A    G TP+HVA     + +V LL   GA  
Sbjct: 378 FTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436

Query: 202 DKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLL 261
           D      G + LH+A  A   +V+  LLR GA   AR    +TPL  A       + +LL
Sbjct: 437 DVTN-IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 495

Query: 262 RAHGA 266
             H A
Sbjct: 496 LQHMA 500



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 1/107 (0%)

Query: 172 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231
           N  G   LH+A     V +V+ L   G+ +D      G + LH+A  A  A+V+++L++ 
Sbjct: 40  NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-GNTALHIASLAGQAEVVKVLVKE 98

Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 278
           GAN  A+   G TPL  A    +  + + L  +GA +    ++   P
Sbjct: 99  GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 145



 Score = 31.6 bits (70), Expect = 0.92
 Identities = 20/61 (32%), Positives = 25/61 (40%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           D    LG T L +A   G    V  L   GA +    + G+T LH A + G       LL
Sbjct: 701 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 760

Query: 116 Q 116
           Q
Sbjct: 761 Q 761



 Score = 29.6 bits (65), Expect = 3.5
 Identities = 18/45 (40%), Positives = 22/45 (48%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVG 106
           G T LH AA  G T  +  L   GA        G+TAL +A R+G
Sbjct: 740 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 784


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 66/217 (30%), Positives = 93/217 (42%), Gaps = 27/217 (12%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           D+ N  G+TALH+AA  G+   V  L   GA +    R   T LH+A R+G     + LL
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517

Query: 116 QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEA----- 170
           Q            ++A  PD      +TP+ +          E   +   + LEA     
Sbjct: 518 Q------------HMAH-PDAATTNGYTPLHI-------SAREGQVDVASVLLEAGAAHS 557

Query: 171 -ENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLL 229
               +G TPLHVA  +  +++ +LL    A  D      G +PLH+A       V  LLL
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLL 616

Query: 230 RAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
             GA+P A    G TPL  A  +    +A  L  +GA
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653



 Score = 68.2 bits (165), Expect = 9e-12
 Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 17/208 (8%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH++A  G+      L  AGA   +A ++G T LH+A + G+   A+ LLQ R   
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA-- 587

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES-EEDWKLQLEAENYEGHTPLH 180
                        D       TP+ +    D +K      E+       A+N  G+TPLH
Sbjct: 588 -----------AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--GYTPLH 634

Query: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240
           +A     +++   L + GA+ +      G +PLHLA +    D++ LLL  GAN      
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQ-GVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 693

Query: 241 GGRTPLGSAMLRPNPILARLLRAHGAPE 268
            G T L  A       +A +L  HGA +
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQ 721



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 60/243 (24%), Positives = 98/243 (40%), Gaps = 38/243 (15%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           +D     G TALH+A++ G+   V+ L   GA +    + G T L++A +       + L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 115 LQPRPRRPREAPDTY------LAQGPD------------------------RTPDTNHTP 144
           L+    +     D +      L QG +                        R  DT    
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 209

Query: 145 VALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKP 204
           + L  D + + +        K+ +      G TPLH+A  + +V +  LL + GA +D  
Sbjct: 210 LLLQNDHNADVQS-------KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262

Query: 205 EPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAH 264
               G +PLH+A +    ++++LLL  G    A+   G TPL  A    +  +  LL   
Sbjct: 263 ARN-GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321

Query: 265 GAP 267
           GAP
Sbjct: 322 GAP 324



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 64/239 (26%), Positives = 95/239 (39%), Gaps = 30/239 (12%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           ++ Q+  G T L++AA       V+ L   GA    A   G T L +A + G +     L
Sbjct: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182

Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEE-----ESEEDWKLQLE 169
           L+   +     P  ++A   D   DT    + L  D + + + +      +E  +     
Sbjct: 183 LENDTKGKVRLPALHIAARKD---DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239

Query: 170 AENY---------------------EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 208
           A +Y                      G TPLHVA    +  MV+LL D G  +D  +   
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA-KTRD 298

Query: 209 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
           G +PLH A  +    V+ELLL  GA   AR   G +PL  A    +    + L  H AP
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 63/234 (26%), Positives = 88/234 (37%), Gaps = 32/234 (13%)

Query: 59  NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPR 118
           N  G  ALHLAA  G    V++L   G+ +  A ++G+TALH+A   G     + L++  
Sbjct: 61  NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120

Query: 119 PRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES--EEDWKLQLEAENYEGH 176
                ++ + +           NH  V  Y    LE    +S   ED    L     +GH
Sbjct: 121 ANINAQSQNGFTPL--YMAAQENHIDVVKYL---LENGANQSTATEDGFTPLAVALQQGH 175

Query: 177 T------------------PLHVAVIHKDVEMVRLL--RDAGADLDKP-----EPTCGRS 211
                               LH+A    D +   LL   D  AD+            G +
Sbjct: 176 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 235

Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
           PLH+A      +V  LLL  GA        G TPL  A  R N  + +LL   G
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 63/240 (26%), Positives = 86/240 (35%), Gaps = 48/240 (20%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T +H+AA +G  + V  L   GA   V   RG TALH+A R G     R L       
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL------- 483

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
                   L  G                                  ++A   E  TPLH+
Sbjct: 484 --------LRNGA--------------------------------LVDARAREEQTPLHI 503

Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
           A      E+V+LL    A  D    T G +PLH++      DV  +LL AGA  +     
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAAT-TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK 562

Query: 242 GRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGSP 301
           G TPL  A    +  +A+LL    A           P   ++  D+    +   E+  SP
Sbjct: 563 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 53/192 (27%), Positives = 77/192 (40%), Gaps = 23/192 (11%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH+AA   +      L   GA   +  ++G T LHLA + G       LL      
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688

Query: 122 PREAPD----TYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT 177
                      +LA   D+    N   +       L K   + +   KL        G+T
Sbjct: 689 HMSTKSGLTSLHLAAQEDKV---NVADI-------LTKHGADQDAHTKL--------GYT 730

Query: 178 PLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAA 237
           PL VA  + +V+MV  L   GA+++      G +PLH A +     ++ +LL+ GA P A
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKPNA 789

Query: 238 RMYGGRTPLGSA 249
               G T L  A
Sbjct: 790 TTANGNTALAIA 801



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 65/245 (26%), Positives = 88/245 (35%), Gaps = 48/245 (19%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGL---------------------CVAER 93
           +D +   G T LH AA  G    VE L   GA L                     CV   
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351

Query: 94  RGH------------TALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTN 141
             H            TALH+A   G +   + LL  R               P+      
Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR-------------ANPNARALNG 398

Query: 142 HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADL 201
            TP+ +    +  K  E   + +   ++A    G TP+HVA     + +V LL   GA  
Sbjct: 399 FTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457

Query: 202 DKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLL 261
           D      G + LH+A  A   +V+  LLR GA   AR    +TPL  A       + +LL
Sbjct: 458 DVTN-IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516

Query: 262 RAHGA 266
             H A
Sbjct: 517 LQHMA 521



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 1/107 (0%)

Query: 172 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231
           N  G   LH+A     V +V+ L   G+ +D      G + LH+A  A  A+V+++L++ 
Sbjct: 61  NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-GNTALHIASLAGQAEVVKVLVKE 119

Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 278
           GAN  A+   G TPL  A    +  + + L  +GA +    ++   P
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166



 Score = 31.6 bits (70), Expect = 0.92
 Identities = 20/61 (32%), Positives = 25/61 (40%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           D    LG T L +A   G    V  L   GA +    + G+T LH A + G       LL
Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 781

Query: 116 Q 116
           Q
Sbjct: 782 Q 782



 Score = 29.6 bits (65), Expect = 3.5
 Identities = 18/45 (40%), Positives = 22/45 (48%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVG 106
           G T LH AA  G T  +  L   GA        G+TAL +A R+G
Sbjct: 761 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 805


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 66/217 (30%), Positives = 93/217 (42%), Gaps = 27/217 (12%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           D+ N  G+TALH+AA  G+   V  L   GA +    R   T LH+A R+G     + LL
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517

Query: 116 QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEA----- 170
           Q            ++A  PD      +TP+ +          E   +   + LEA     
Sbjct: 518 Q------------HMAH-PDAATTNGYTPLHI-------SAREGQVDVASVLLEAGAAHS 557

Query: 171 -ENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLL 229
               +G TPLHVA  +  +++ +LL    A  D      G +PLH+A       V  LLL
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLL 616

Query: 230 RAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
             GA+P A    G TPL  A  +    +A  L  +GA
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653



 Score = 68.2 bits (165), Expect = 9e-12
 Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 17/208 (8%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH++A  G+      L  AGA   +A ++G T LH+A + G+   A+ LLQ R   
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA-- 587

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES-EEDWKLQLEAENYEGHTPLH 180
                        D       TP+ +    D +K      E+       A+N  G+TPLH
Sbjct: 588 -----------AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--GYTPLH 634

Query: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240
           +A     +++   L + GA+ +      G +PLHLA +    D++ LLL  GAN      
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQ-GVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 693

Query: 241 GGRTPLGSAMLRPNPILARLLRAHGAPE 268
            G T L  A       +A +L  HGA +
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQ 721



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 60/243 (24%), Positives = 98/243 (40%), Gaps = 38/243 (15%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           +D     G TALH+A++ G+   V+ L   GA +    + G T L++A +       + L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 115 LQPRPRRPREAPDTY------LAQGPD------------------------RTPDTNHTP 144
           L+    +     D +      L QG +                        R  DT    
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 209

Query: 145 VALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKP 204
           + L  D + + +        K+ +      G TPLH+A  + +V +  LL + GA +D  
Sbjct: 210 LLLQNDHNADVQS-------KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262

Query: 205 EPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAH 264
               G +PLH+A +    ++++LLL  G    A+   G TPL  A    +  +  LL   
Sbjct: 263 ARN-GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321

Query: 265 GAP 267
           GAP
Sbjct: 322 GAP 324



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 64/239 (26%), Positives = 95/239 (39%), Gaps = 30/239 (12%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           ++ Q+  G T L++AA       V+ L   GA    A   G T L +A + G +     L
Sbjct: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182

Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEE-----ESEEDWKLQLE 169
           L+   +     P  ++A   D   DT    + L  D + + + +      +E  +     
Sbjct: 183 LENDTKGKVRLPALHIAARKD---DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239

Query: 170 AENY---------------------EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 208
           A +Y                      G TPLHVA    +  MV+LL D G  +D  +   
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA-KTRD 298

Query: 209 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
           G +PLH A  +    V+ELLL  GA   AR   G +PL  A    +    + L  H AP
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 63/234 (26%), Positives = 88/234 (37%), Gaps = 32/234 (13%)

Query: 59  NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPR 118
           N  G  ALHLAA  G    V++L   G+ +  A ++G+TALH+A   G     + L++  
Sbjct: 61  NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120

Query: 119 PRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES--EEDWKLQLEAENYEGH 176
                ++ + +           NH  V  Y    LE    +S   ED    L     +GH
Sbjct: 121 ANINAQSQNGFTPL--YMAAQENHIDVVKYL---LENGANQSTATEDGFTPLAVALQQGH 175

Query: 177 T------------------PLHVAVIHKDVEMVRLL--RDAGADLDKP-----EPTCGRS 211
                               LH+A    D +   LL   D  AD+            G +
Sbjct: 176 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 235

Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
           PLH+A      +V  LLL  GA        G TPL  A  R N  + +LL   G
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 63/240 (26%), Positives = 86/240 (35%), Gaps = 48/240 (20%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T +H+AA +G  + V  L   GA   V   RG TALH+A R G     R L       
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL------- 483

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
                   L  G                                  ++A   E  TPLH+
Sbjct: 484 --------LRNGA--------------------------------LVDARAREEQTPLHI 503

Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
           A      E+V+LL    A  D    T G +PLH++      DV  +LL AGA  +     
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAAT-TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK 562

Query: 242 GRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGSP 301
           G TPL  A    +  +A+LL    A           P   ++  D+    +   E+  SP
Sbjct: 563 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 53/192 (27%), Positives = 77/192 (40%), Gaps = 23/192 (11%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH+AA   +      L   GA   +  ++G T LHLA + G       LL      
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688

Query: 122 PREAPD----TYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT 177
                      +LA   D+    N   +       L K   + +   KL        G+T
Sbjct: 689 HMSTKSGLTSLHLAAQEDKV---NVADI-------LTKHGADQDAHTKL--------GYT 730

Query: 178 PLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAA 237
           PL VA  + +V+MV  L   GA+++      G +PLH A +     ++ +LL+ GA P A
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKPNA 789

Query: 238 RMYGGRTPLGSA 249
               G T L  A
Sbjct: 790 TTANGNTALAIA 801



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 65/245 (26%), Positives = 88/245 (35%), Gaps = 48/245 (19%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGL---------------------CVAER 93
           +D +   G T LH AA  G    VE L   GA L                     CV   
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351

Query: 94  RGH------------TALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTN 141
             H            TALH+A   G +   + LL  R               P+      
Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR-------------ANPNARALNG 398

Query: 142 HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADL 201
            TP+ +    +  K  E   + +   ++A    G TP+HVA     + +V LL   GA  
Sbjct: 399 FTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457

Query: 202 DKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLL 261
           D      G + LH+A  A   +V+  LLR GA   AR    +TPL  A       + +LL
Sbjct: 458 DVTN-IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516

Query: 262 RAHGA 266
             H A
Sbjct: 517 LQHMA 521



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 1/107 (0%)

Query: 172 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231
           N  G   LH+A     V +V+ L   G+ +D      G + LH+A  A  A+V+++L++ 
Sbjct: 61  NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-GNTALHIASLAGQAEVVKVLVKE 119

Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 278
           GAN  A+   G TPL  A    +  + + L  +GA +    ++   P
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166



 Score = 31.6 bits (70), Expect = 0.92
 Identities = 20/61 (32%), Positives = 25/61 (40%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           D    LG T L +A   G    V  L   GA +    + G+T LH A + G       LL
Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 781

Query: 116 Q 116
           Q
Sbjct: 782 Q 782



 Score = 29.6 bits (65), Expect = 3.5
 Identities = 18/45 (40%), Positives = 22/45 (48%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVG 106
           G T LH AA  G T  +  L   GA        G+TAL +A R+G
Sbjct: 761 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 805


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 32/236 (13%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           +D   + G T LH+A+ +G    V+ L   GA   V+  +  T LH+A R G    A+ L
Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489

Query: 115 LQPRPRRPREAPDTYLA--------------------QGPDRTPDTNHTPVAL-----YP 149
           LQ + +   +A D                          P+      HTP+ +     + 
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549

Query: 150 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 209
           ++ L   E+E+ +           +G TPLHVA  +  V +  LL +  A  +      G
Sbjct: 550 ETVLALLEKEASQ------ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN-G 602

Query: 210 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
            +PLH+AV     D+++LLL  G +P +  + G TPL  A  +    +AR L  +G
Sbjct: 603 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 658



 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 59/193 (30%), Positives = 82/193 (42%), Gaps = 25/193 (12%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH+AA   +      L   G        +G T LHLA + G HA   ALL  +   
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQAN 693

Query: 122 PREAPDTYLAQGPDRTP-----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176
                   L      TP        H PVA      L K          + ++A    G+
Sbjct: 694 GN------LGNKSGLTPLHLVAQEGHVPVA----DVLIKHG--------VMVDATTRMGY 735

Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236
           TPLHVA  + ++++V+ L    AD++  +   G SPLH A +    D++ LLL+ GA+P 
Sbjct: 736 TPLHVASHYGNIKLVKFLLQHQADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794

Query: 237 ARMYGGRTPLGSA 249
                G TPL  A
Sbjct: 795 EVSSDGTTPLAIA 807



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 66/234 (28%), Positives = 92/234 (39%), Gaps = 28/234 (11%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           +L    G T LH+AA  G   TV  L    A      ++G T LH+A + G    A  LL
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 589

Query: 116 QPRPRRPREAPDTYLAQ--------------------GPDRTPDTN-HTPVALYPDSDLE 154
           + R   P  A    L                      G   +P  N +TP+ +    + +
Sbjct: 590 E-RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-Q 647

Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSP 212
            E   S   +     AE+ +G TPLH+A      EMV LL  + A  +L       G +P
Sbjct: 648 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTP 704

Query: 213 LHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           LHL  +     V ++L++ G    A    G TPL  A    N  L + L  H A
Sbjct: 705 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 758



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 16/221 (7%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G TALH+AA+ G+   V +L   GA +    ++G T L++A +       + LL+    +
Sbjct: 111 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 170

Query: 122 PREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAE 171
                D +      L QG +       +         P   +    +++     L     
Sbjct: 171 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 230

Query: 172 NYE-----GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 226
           N +     G TPLH+A  ++++ + +LL + GA ++   P  G +PLH+A       ++ 
Sbjct: 231 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVR 289

Query: 227 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
           LLL  GA    +     TPL  A    +  ++ +L  HGAP
Sbjct: 290 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 330



 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 65/225 (28%), Positives = 87/225 (38%), Gaps = 24/225 (10%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH+A        +E L   GA +      G T LH+A  +G     + LLQ R   
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGAS 462

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW---------------KL 166
           P    +  +           HT VA Y   +  K   ++++D                KL
Sbjct: 463 P-NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 521

Query: 167 QLE------AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ 220
            LE           GHTPLH+A     VE V  L +  A         G +PLH+A +  
Sbjct: 522 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYG 580

Query: 221 AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
              V ELLL   A+P A    G TPL  A+   N  + +LL   G
Sbjct: 581 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625



 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 29/238 (12%)

Query: 59  NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115
           N  G   LHLA+  G    V +L      L    ++G+TALH+A   G     R L+   
Sbjct: 75  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134

Query: 116 -QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-----KLQLE 169
                +  +     Y+A         NH  V  +   +   +   +E+ +      LQ  
Sbjct: 135 ANVNAQSQKGFTPLYMA------AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 188

Query: 170 AENYEGH------------TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAV 217
            EN   H              LH+A  + D     +L     + D    T G +PLH+A 
Sbjct: 189 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAA 247

Query: 218 EAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDE 274
             +  +V +LLL  GA+       G TPL  A  R N I+ RLL   GA  E + +DE
Sbjct: 248 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 305



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 25/234 (10%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           D+ +  G T LH+AA     +  + L   GA +    + G T LH+A R G     R LL
Sbjct: 233 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 292

Query: 116 ----QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED--- 163
               Q   +   E    + A   G  R  +    +  P+     + L      ++ D   
Sbjct: 293 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 352

Query: 164 ---WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLH 214
                LQ +AE      +  TPLHVA       + ++L D GA   KP      G +PLH
Sbjct: 353 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLH 409

Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 267
           +A +     V+ELLL+ GA+  A    G TPL  A    + PI+  LL+   +P
Sbjct: 410 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463



 Score = 38.1 bits (87), Expect = 0.010
 Identities = 56/235 (23%), Positives = 85/235 (36%), Gaps = 46/235 (19%)

Query: 64  TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPR 123
           T LH AA  G     E L   GA +    + G + +H+A +     C R LLQ       
Sbjct: 307 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ------- 359

Query: 124 EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAV 183
                Y A+  D T D + TP+ +       +  +    D   +  +    G TPLH+A 
Sbjct: 360 -----YDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIAC 412

Query: 184 IHKDVEMVRLLRDAGADLDK----------------------------PEPTCGR----S 211
               V ++ LL   GA +D                               P        +
Sbjct: 413 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 472

Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           PLH+A  A   +V + LL+  A   A+    +TPL  A    +  + +LL  + A
Sbjct: 473 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 527


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 32/236 (13%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           +D   + G T LH+A+ +G    V+ L   GA   V+  +  T LH+A R G    A+ L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 115 LQPRPRRPREAPDTYLA--------------------QGPDRTPDTNHTPVAL-----YP 149
           LQ + +   +A D                          P+      HTP+ +     + 
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516

Query: 150 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 209
           ++ L   E+E+ +           +G TPLHVA  +  V +  LL +  A  +      G
Sbjct: 517 ETVLALLEKEASQ------ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN-G 569

Query: 210 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
            +PLH+AV     D+++LLL  G +P +  + G TPL  A  +    +AR L  +G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625



 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 59/193 (30%), Positives = 82/193 (42%), Gaps = 25/193 (12%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH+AA   +      L   G        +G T LHLA + G HA   ALL  +   
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQAN 660

Query: 122 PREAPDTYLAQGPDRTP-----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176
                   L      TP        H PVA      L K          + ++A    G+
Sbjct: 661 GN------LGNKSGLTPLHLVAQEGHVPVA----DVLIKHG--------VMVDATTRMGY 702

Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236
           TPLHVA  + ++++V+ L    AD++  +   G SPLH A +    D++ LLL+ GA+P 
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 237 ARMYGGRTPLGSA 249
                G TPL  A
Sbjct: 762 EVSSDGTTPLAIA 774



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 66/234 (28%), Positives = 92/234 (39%), Gaps = 28/234 (11%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           +L    G T LH+AA  G   TV  L    A      ++G T LH+A + G    A  LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 116 QPRPRRPREAPDTYLAQ--------------------GPDRTPDTN-HTPVALYPDSDLE 154
           + R   P  A    L                      G   +P  N +TP+ +    + +
Sbjct: 557 E-RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-Q 614

Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSP 212
            E   S   +     AE+ +G TPLH+A      EMV LL  + A  +L       G +P
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTP 671

Query: 213 LHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           LHL  +     V ++L++ G    A    G TPL  A    N  L + L  H A
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 16/221 (7%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G TALH+AA+ G+   V +L   GA +    ++G T L++A +       + LL+    +
Sbjct: 78  GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137

Query: 122 PREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAE 171
                D +      L QG +       +         P   +    +++     L     
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197

Query: 172 NYE-----GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 226
           N +     G TPLH+A  ++++ + +LL + GA ++   P  G +PLH+A       ++ 
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVR 256

Query: 227 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
           LLL  GA    +     TPL  A    +  ++ +L  HGAP
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297



 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 65/225 (28%), Positives = 87/225 (38%), Gaps = 24/225 (10%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH+A        +E L   GA +      G T LH+A  +G     + LLQ R   
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGAS 429

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW---------------KL 166
           P    +  +           HT VA Y   +  K   ++++D                KL
Sbjct: 430 P-NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488

Query: 167 QLE------AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ 220
            LE           GHTPLH+A     VE V  L +  A         G +PLH+A +  
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYG 547

Query: 221 AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
              V ELLL   A+P A    G TPL  A+   N  + +LL   G
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592



 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 29/238 (12%)

Query: 59  NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115
           N  G   LHLA+  G    V +L      L    ++G+TALH+A   G     R L+   
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 116 -QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-----KLQLE 169
                +  +     Y+A         NH  V  +   +   +   +E+ +      LQ  
Sbjct: 102 ANVNAQSQKGFTPLYMA------AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155

Query: 170 AENYEGH------------TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAV 217
            EN   H              LH+A  + D     +L     + D    T G +PLH+A 
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAA 214

Query: 218 EAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDE 274
             +  +V +LLL  GA+       G TPL  A  R N I+ RLL   GA  E + +DE
Sbjct: 215 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 25/234 (10%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           D+ +  G T LH+AA     +  + L   GA +    + G T LH+A R G     R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 116 ----QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED--- 163
               Q   +   E    + A   G  R  +    +  P+     + L      ++ D   
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319

Query: 164 ---WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLH 214
                LQ +AE      +  TPLHVA       + ++L D GA   KP      G +PLH
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLH 376

Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 267
           +A +     V+ELLL+ GA+  A    G TPL  A    + PI+  LL+   +P
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430



 Score = 38.1 bits (87), Expect = 0.010
 Identities = 56/235 (23%), Positives = 85/235 (36%), Gaps = 46/235 (19%)

Query: 64  TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPR 123
           T LH AA  G     E L   GA +    + G + +H+A +     C R LLQ       
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ------- 326

Query: 124 EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAV 183
                Y A+  D T D + TP+ +       +  +    D   +  +    G TPLH+A 
Sbjct: 327 -----YDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIAC 379

Query: 184 IHKDVEMVRLLRDAGADLDK----------------------------PEPTCGR----S 211
               V ++ LL   GA +D                               P        +
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439

Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           PLH+A  A   +V + LL+  A   A+    +TPL  A    +  + +LL  + A
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 32/236 (13%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           +D   + G T LH+A+ +G    V+ L   GA   V+  +  T LH+A R G    A+ L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 115 LQPRPRRPREAPDTYLA--------------------QGPDRTPDTNHTPVAL-----YP 149
           LQ + +   +A D                          P+      HTP+ +     + 
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516

Query: 150 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 209
           ++ L   E+E+ +           +G TPLHVA  +  V +  LL +  A  +      G
Sbjct: 517 ETVLALLEKEASQ------ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN-G 569

Query: 210 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
            +PLH+AV     D+++LLL  G +P +  + G TPL  A  +    +AR L  +G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625



 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 59/193 (30%), Positives = 82/193 (42%), Gaps = 25/193 (12%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH+AA   +      L   G        +G T LHLA + G HA   ALL  +   
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQAN 660

Query: 122 PREAPDTYLAQGPDRTP-----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176
                   L      TP        H PVA      L K          + ++A    G+
Sbjct: 661 GN------LGNKSGLTPLHLVAQEGHVPVA----DVLIKHG--------VMVDATTRMGY 702

Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236
           TPLHVA  + ++++V+ L    AD++  +   G SPLH A +    D++ LLL+ GA+P 
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 237 ARMYGGRTPLGSA 249
                G TPL  A
Sbjct: 762 EVSSDGTTPLAIA 774



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 66/234 (28%), Positives = 92/234 (39%), Gaps = 28/234 (11%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           +L    G T LH+AA  G   TV  L    A      ++G T LH+A + G    A  LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 116 QPRPRRPREAPDTYLAQ--------------------GPDRTPDTN-HTPVALYPDSDLE 154
           + R   P  A    L                      G   +P  N +TP+ +    + +
Sbjct: 557 E-RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-Q 614

Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSP 212
            E   S   +     AE+ +G TPLH+A      EMV LL  + A  +L       G +P
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTP 671

Query: 213 LHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           LHL  +     V ++L++ G    A    G TPL  A    N  L + L  H A
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 16/221 (7%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G TALH+AA+ G+   V +L   GA +    ++G T L++A +       + LL+    +
Sbjct: 78  GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137

Query: 122 PREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAE 171
                D +      L QG +       +         P   +    +++     L     
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197

Query: 172 NYE-----GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 226
           N +     G TPLH+A  ++++ + +LL + GA ++   P  G +PLH+A       ++ 
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVR 256

Query: 227 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
           LLL  GA    +     TPL  A    +  ++ +L  HGAP
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297



 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 65/225 (28%), Positives = 87/225 (38%), Gaps = 24/225 (10%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH+A        +E L   GA +      G T LH+A  +G     + LLQ R   
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGAS 429

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW---------------KL 166
           P    +  +           HT VA Y   +  K   ++++D                KL
Sbjct: 430 P-NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488

Query: 167 QLE------AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ 220
            LE           GHTPLH+A     VE V  L +  A         G +PLH+A +  
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYG 547

Query: 221 AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
              V ELLL   A+P A    G TPL  A+   N  + +LL   G
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592



 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 29/238 (12%)

Query: 59  NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115
           N  G   LHLA+  G    V +L      L    ++G+TALH+A   G     R L+   
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 116 -QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-----KLQLE 169
                +  +     Y+A         NH  V  +   +   +   +E+ +      LQ  
Sbjct: 102 ANVNAQSQKGFTPLYMA------AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155

Query: 170 AENYEGH------------TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAV 217
            EN   H              LH+A  + D     +L     + D    T G +PLH+A 
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAA 214

Query: 218 EAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDE 274
             +  +V +LLL  GA+       G TPL  A  R N I+ RLL   GA  E + +DE
Sbjct: 215 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 25/234 (10%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           D+ +  G T LH+AA     +  + L   GA +    + G T LH+A R G     R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 116 ----QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED--- 163
               Q   +   E    + A   G  R  +    +  P+     + L      ++ D   
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319

Query: 164 ---WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLH 214
                LQ +AE      +  TPLHVA       + ++L D GA   KP      G +PLH
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLH 376

Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 267
           +A +     V+ELLL+ GA+  A    G TPL  A    + PI+  LL+   +P
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430



 Score = 38.1 bits (87), Expect = 0.010
 Identities = 56/235 (23%), Positives = 85/235 (36%), Gaps = 46/235 (19%)

Query: 64  TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPR 123
           T LH AA  G     E L   GA +    + G + +H+A +     C R LLQ       
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ------- 326

Query: 124 EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAV 183
                Y A+  D T D + TP+ +       +  +    D   +  +    G TPLH+A 
Sbjct: 327 -----YDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIAC 379

Query: 184 IHKDVEMVRLLRDAGADLDK----------------------------PEPTCGR----S 211
               V ++ LL   GA +D                               P        +
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439

Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           PLH+A  A   +V + LL+  A   A+    +TPL  A    +  + +LL  + A
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 32/236 (13%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           +D   + G T LH+A+ +G    V+ L   GA   V+  +  T LH+A R G    A+ L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 115 LQPRPRRPREAPDTYLA--------------------QGPDRTPDTNHTPVAL-----YP 149
           LQ + +   +A D                          P+      HTP+ +     + 
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516

Query: 150 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 209
           ++ L   E+E+ +           +G TPLHVA  +  V +  LL +  A  +      G
Sbjct: 517 ETVLALLEKEASQ------ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN-G 569

Query: 210 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
            +PLH+AV     D+++LLL  G +P +  + G TPL  A  +    +AR L  +G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625



 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 59/193 (30%), Positives = 82/193 (42%), Gaps = 25/193 (12%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH+AA   +      L   G        +G T LHLA + G HA   ALL  +   
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQAN 660

Query: 122 PREAPDTYLAQGPDRTP-----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176
                   L      TP        H PVA      L K          + ++A    G+
Sbjct: 661 GN------LGNKSGLTPLHLVAQEGHVPVA----DVLIKHG--------VMVDATTRMGY 702

Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236
           TPLHVA  + ++++V+ L    AD++  +   G SPLH A +    D++ LLL+ GA+P 
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 237 ARMYGGRTPLGSA 249
                G TPL  A
Sbjct: 762 EVSSDGTTPLAIA 774



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 66/234 (28%), Positives = 92/234 (39%), Gaps = 28/234 (11%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           +L    G T LH+AA  G   TV  L    A      ++G T LH+A + G    A  LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 116 QPRPRRPREAPDTYLAQ--------------------GPDRTPDTN-HTPVALYPDSDLE 154
           + R   P  A    L                      G   +P  N +TP+ +    + +
Sbjct: 557 E-RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-Q 614

Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSP 212
            E   S   +     AE+ +G TPLH+A      EMV LL  + A  +L       G +P
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTP 671

Query: 213 LHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           LHL  +     V ++L++ G    A    G TPL  A    N  L + L  H A
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 16/221 (7%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G TALH+AA+ G+   V +L   GA +    ++G T L++A +       + LL+    +
Sbjct: 78  GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137

Query: 122 PREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAE 171
                D +      L QG +       +         P   +    +++     L     
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197

Query: 172 NYE-----GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 226
           N +     G TPLH+A  ++++ + +LL + GA ++   P  G +PLH+A       ++ 
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVR 256

Query: 227 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
           LLL  GA    +     TPL  A    +  ++ +L  HGAP
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297



 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 65/225 (28%), Positives = 87/225 (38%), Gaps = 24/225 (10%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH+A        +E L   GA +      G T LH+A  +G     + LLQ R   
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGAS 429

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW---------------KL 166
           P    +  +           HT VA Y   +  K   ++++D                KL
Sbjct: 430 P-NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488

Query: 167 QLE------AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ 220
            LE           GHTPLH+A     VE V  L +  A         G +PLH+A +  
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYG 547

Query: 221 AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
              V ELLL   A+P A    G TPL  A+   N  + +LL   G
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592



 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 29/238 (12%)

Query: 59  NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115
           N  G   LHLA+  G    V +L      L    ++G+TALH+A   G     R L+   
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 116 -QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-----KLQLE 169
                +  +     Y+A         NH  V  +   +   +   +E+ +      LQ  
Sbjct: 102 ANVNAQSQKGFTPLYMA------AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155

Query: 170 AENYEGH------------TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAV 217
            EN   H              LH+A  + D     +L     + D    T G +PLH+A 
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAA 214

Query: 218 EAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDE 274
             +  +V +LLL  GA+       G TPL  A  R N I+ RLL   GA  E + +DE
Sbjct: 215 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 25/234 (10%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           D+ +  G T LH+AA     +  + L   GA +    + G T LH+A R G     R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 116 ----QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED--- 163
               Q   +   E    + A   G  R  +    +  P+     + L      ++ D   
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319

Query: 164 ---WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLH 214
                LQ +AE      +  TPLHVA       + ++L D GA   KP      G +PLH
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLH 376

Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 267
           +A +     V+ELLL+ GA+  A    G TPL  A    + PI+  LL+   +P
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430



 Score = 38.1 bits (87), Expect = 0.010
 Identities = 56/235 (23%), Positives = 85/235 (36%), Gaps = 46/235 (19%)

Query: 64  TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPR 123
           T LH AA  G     E L   GA +    + G + +H+A +     C R LLQ       
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ------- 326

Query: 124 EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAV 183
                Y A+  D T D + TP+ +       +  +    D   +  +    G TPLH+A 
Sbjct: 327 -----YDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIAC 379

Query: 184 IHKDVEMVRLLRDAGADLDK----------------------------PEPTCGR----S 211
               V ++ LL   GA +D                               P        +
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439

Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           PLH+A  A   +V + LL+  A   A+    +TPL  A    +  + +LL  + A
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 32/236 (13%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           +D   + G T LH+A+ +G    V+ L   GA   V+  +  T LH+A R G    A+ L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 115 LQPRPRRPREAPDTYLA--------------------QGPDRTPDTNHTPVAL-----YP 149
           LQ + +   +A D                          P+      HTP+ +     + 
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516

Query: 150 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 209
           ++ L   E+E+ +           +G TPLHVA  +  V +  LL +  A  +      G
Sbjct: 517 ETVLALLEKEASQ------ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN-G 569

Query: 210 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
            +PLH+AV     D+++LLL  G +P +  + G TPL  A  +    +AR L  +G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625



 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 59/193 (30%), Positives = 82/193 (42%), Gaps = 25/193 (12%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH+AA   +      L   G        +G T LHLA + G HA   ALL  +   
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQAN 660

Query: 122 PREAPDTYLAQGPDRTP-----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176
                   L      TP        H PVA      L K          + ++A    G+
Sbjct: 661 GN------LGNKSGLTPLHLVAQEGHVPVA----DVLIKHG--------VMVDATTRMGY 702

Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236
           TPLHVA  + ++++V+ L    AD++  +   G SPLH A +    D++ LLL+ GA+P 
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 237 ARMYGGRTPLGSA 249
                G TPL  A
Sbjct: 762 EVSSDGTTPLAIA 774



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 66/234 (28%), Positives = 92/234 (39%), Gaps = 28/234 (11%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           +L    G T LH+AA  G   TV  L    A      ++G T LH+A + G    A  LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 116 QPRPRRPREAPDTYLAQ--------------------GPDRTPDTN-HTPVALYPDSDLE 154
           + R   P  A    L                      G   +P  N +TP+ +    + +
Sbjct: 557 E-RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-Q 614

Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSP 212
            E   S   +     AE+ +G TPLH+A      EMV LL  + A  +L       G +P
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTP 671

Query: 213 LHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           LHL  +     V ++L++ G    A    G TPL  A    N  L + L  H A
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 16/221 (7%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G TALH+AA+ G+   V +L   GA +    ++G T L++A +       + LL+    +
Sbjct: 78  GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137

Query: 122 PREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAE 171
                D +      L QG +       +         P   +    +++     L     
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197

Query: 172 NYE-----GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 226
           N +     G TPLH+A  ++++ + +LL + GA ++   P  G +PLH+A       ++ 
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVR 256

Query: 227 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
           LLL  GA    +     TPL  A    +  ++ +L  HGAP
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297



 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 65/225 (28%), Positives = 87/225 (38%), Gaps = 24/225 (10%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G T LH+A        +E L   GA +      G T LH+A  +G     + LLQ R   
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGAS 429

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW---------------KL 166
           P    +  +           HT VA Y   +  K   ++++D                KL
Sbjct: 430 P-NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488

Query: 167 QLE------AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ 220
            LE           GHTPLH+A     VE V  L +  A         G +PLH+A +  
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYG 547

Query: 221 AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
              V ELLL   A+P A    G TPL  A+   N  + +LL   G
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592



 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 29/238 (12%)

Query: 59  NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115
           N  G   LHLA+  G    V +L      L    ++G+TALH+A   G     R L+   
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 116 -QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-----KLQLE 169
                +  +     Y+A         NH  V  +   +   +   +E+ +      LQ  
Sbjct: 102 ANVNAQSQKGFTPLYMA------AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155

Query: 170 AENYEGH------------TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAV 217
            EN   H              LH+A  + D     +L     + D    T G +PLH+A 
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAA 214

Query: 218 EAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDE 274
             +  +V +LLL  GA+       G TPL  A  R N I+ RLL   GA  E + +DE
Sbjct: 215 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 25/234 (10%)

Query: 56  DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           D+ +  G T LH+AA     +  + L   GA +    + G T LH+A R G     R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 116 ----QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED--- 163
               Q   +   E    + A   G  R  +    +  P+     + L      ++ D   
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319

Query: 164 ---WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLH 214
                LQ +AE      +  TPLHVA       + ++L D GA   KP      G +PLH
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLH 376

Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 267
           +A +     V+ELLL+ GA+  A    G TPL  A    + PI+  LL+   +P
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430



 Score = 38.1 bits (87), Expect = 0.010
 Identities = 56/235 (23%), Positives = 85/235 (36%), Gaps = 46/235 (19%)

Query: 64  TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPR 123
           T LH AA  G     E L   GA +    + G + +H+A +     C R LLQ       
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ------- 326

Query: 124 EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAV 183
                Y A+  D T D + TP+ +       +  +    D   +  +    G TPLH+A 
Sbjct: 327 -----YDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIAC 379

Query: 184 IHKDVEMVRLLRDAGADLDK----------------------------PEPTCGR----S 211
               V ++ LL   GA +D                               P        +
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439

Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           PLH+A  A   +V + LL+  A   A+    +TPL  A    +  + +LL  + A
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494


>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
           [Homo sapiens]
          Length = 474

 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 75/229 (32%), Positives = 97/229 (42%), Gaps = 42/229 (18%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G+TALH A   G T+ V  L  AGA   +A++ G   LHL    G   CA  LL+     
Sbjct: 193 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR----- 247

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQL----EAENYEGHT 177
                  + A+   R+ +   TP  L+  + L   E     D  L+     +A N EG T
Sbjct: 248 -------FGARVDGRSEEEEETP--LHVAARLGHVE---LADLLLRRGACPDARNAEGWT 295

Query: 178 PLHV-------------AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADV 224
           PL               A   + +++  LL  AGAD D  +    R PLHLA     A V
Sbjct: 296 PLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR-PLHLACRRGHAAV 354

Query: 225 LELLLRAGANPAARMYGGRTPLGSAMLRPNPILA-------RLLRAHGA 266
           +ELLL  G +     YGG TPL  A+  P   LA       R L  HGA
Sbjct: 355 VELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 46/138 (33%), Positives = 60/138 (43%), Gaps = 14/138 (10%)

Query: 147 LYPDSDLEKEEEESEEDWK-----LQLEAENYEGH--TPLHVAVIHKDVEMVRLLRDAGA 199
           L PDS  +  + E   D++     L+L +  YE    TPLHVA      E++RLL    A
Sbjct: 126 LAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRA 185

Query: 200 DLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL----GSAMLRPNP 255
             D      GR+ LH A  A     + +LL AGA+P      G+ PL    G   L    
Sbjct: 186 RPDSAPG--GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAE 243

Query: 256 ILARL-LRAHGAPEPEGE 272
           +L R   R  G  E E E
Sbjct: 244 LLLRFGARVDGRSEEEEE 261


>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
           [Homo sapiens]
          Length = 512

 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 75/229 (32%), Positives = 97/229 (42%), Gaps = 42/229 (18%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G+TALH A   G T+ V  L  AGA   +A++ G   LHL    G   CA  LL+     
Sbjct: 193 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR----- 247

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQL----EAENYEGHT 177
                  + A+   R+ +   TP  L+  + L   E     D  L+     +A N EG T
Sbjct: 248 -------FGARVDGRSEEEEETP--LHVAARLGHVE---LADLLLRRGACPDARNAEGWT 295

Query: 178 PLHV-------------AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADV 224
           PL               A   + +++  LL  AGAD D  +    R PLHLA     A V
Sbjct: 296 PLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR-PLHLACRRGHAAV 354

Query: 225 LELLLRAGANPAARMYGGRTPLGSAMLRPNPILA-------RLLRAHGA 266
           +ELLL  G +     YGG TPL  A+  P   LA       R L  HGA
Sbjct: 355 VELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 46/138 (33%), Positives = 60/138 (43%), Gaps = 14/138 (10%)

Query: 147 LYPDSDLEKEEEESEEDWK-----LQLEAENYEGH--TPLHVAVIHKDVEMVRLLRDAGA 199
           L PDS  +  + E   D++     L+L +  YE    TPLHVA      E++RLL    A
Sbjct: 126 LAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRA 185

Query: 200 DLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL----GSAMLRPNP 255
             D      GR+ LH A  A     + +LL AGA+P      G+ PL    G   L    
Sbjct: 186 RPDSAPG--GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAE 243

Query: 256 ILARL-LRAHGAPEPEGE 272
           +L R   R  G  E E E
Sbjct: 244 LLLRFGARVDGRSEEEEE 261


>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
           [Homo sapiens]
          Length = 452

 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 75/229 (32%), Positives = 97/229 (42%), Gaps = 42/229 (18%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G+TALH A   G T+ V  L  AGA   +A++ G   LHL    G   CA  LL+     
Sbjct: 133 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR----- 187

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQL----EAENYEGHT 177
                  + A+   R+ +   TP  L+  + L   E     D  L+     +A N EG T
Sbjct: 188 -------FGARVDGRSEEEEETP--LHVAARLGHVE---LADLLLRRGACPDARNAEGWT 235

Query: 178 PLHV-------------AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADV 224
           PL               A   + +++  LL  AGAD D  +    R PLHLA     A V
Sbjct: 236 PLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR-PLHLACRRGHAAV 294

Query: 225 LELLLRAGANPAARMYGGRTPLGSAMLRPNPILA-------RLLRAHGA 266
           +ELLL  G +     YGG TPL  A+  P   LA       R L  HGA
Sbjct: 295 VELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 343



 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 61/194 (31%), Positives = 73/194 (37%), Gaps = 19/194 (9%)

Query: 96  HTALHLACRVGAHACA--RALLQPRPRRPREAP---DTYLAQGPDRTPDTNHTPVALYPD 150
           H   HL C   A AC   R   +P    PR +P        Q    T D         P 
Sbjct: 10  HWGHHLGCLPSAPACRIWRPHSRPAWEPPRPSPLLCQDMALQNALYTGDLARLQELFPPH 69

Query: 151 S--DLEKEEEESEEDWKLQ---LEAENYEGH--TPLHVAVIHKDVEMVRLLRDAGADLDK 203
           S  DL  E   +E  W      L +  YE    TPLHVA      E++RLL    A  D 
Sbjct: 70  STADLLLESRAAEPRWSSHQRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDS 129

Query: 204 PEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL----GSAMLRPNPILAR 259
                GR+ LH A  A     + +LL AGA+P      G+ PL    G   L    +L R
Sbjct: 130 APG--GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR 187

Query: 260 L-LRAHGAPEPEGE 272
              R  G  E E E
Sbjct: 188 FGARVDGRSEEEEE 201


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 62/205 (30%), Positives = 81/205 (39%), Gaps = 48/205 (23%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G   LH AA  G+  T   L   GA +   ER G T LHLA +      AR L+      
Sbjct: 428 GWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV------ 481

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
                         R  D N                                EG TPLHV
Sbjct: 482 -------------SRQADPN----------------------------LHEAEGKTPLHV 500

Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
           A     V +V+LL   GA+LD  +    R+PLHLAVE      ++ LL++GA P A    
Sbjct: 501 AAYFGHVSLVKLLTSQGAELDAQQRNL-RTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559

Query: 242 GRTPLGSAMLRPNPILARLLRAHGA 266
           G  PL +A  R   ++ ++L  +GA
Sbjct: 560 GYGPLHTAAARGKYLICKMLLRYGA 584



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 57/192 (29%), Positives = 85/192 (44%), Gaps = 17/192 (8%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G+T LH+AA  G  S V+ L + GA L   +R   T LHLA   G     + LL+     
Sbjct: 494 GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS---- 549

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEE-ESEEDWKLQLEAENYEGHTPLH 180
                       PD    + + P  L+  +   K    +    +   LE   ++G TPLH
Sbjct: 550 ---------GAVPDALDQSGYGP--LHTAAARGKYLICKMLLRYGASLELPTHQGWTPLH 598

Query: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240
           +A     +E++ LL ++ A++         +PLHLA       V+  LL+ GA+P A   
Sbjct: 599 LAAYKGHLEIIHLLAESHANMGALGAV-NWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657

Query: 241 GGRTPLGSAMLR 252
            G TPL  A+ R
Sbjct: 658 SGWTPLHLAVQR 669



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 51/191 (26%), Positives = 76/191 (39%), Gaps = 17/191 (8%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           ++L    G T LHLAA  G    +  L  + A +        T LHLA R G  A   AL
Sbjct: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645

Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 174
           LQ                 P+    +  TP+ L              E     + A N  
Sbjct: 646 LQ-------------CGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEH-HANVHARNKV 691

Query: 175 GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
           G TP H+A +  +  ++++L +AGA LD  +     +PL LA+ ++   ++  L   G  
Sbjct: 692 GWTPAHLAALKGNTAILKVLVEAGAQLDVQDGV-SCTPLQLALRSRKQGIMSFL--EGKE 748

Query: 235 PAARMYGGRTP 245
           P+    GG  P
Sbjct: 749 PSVATLGGSKP 759



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 67/219 (30%), Positives = 94/219 (42%), Gaps = 18/219 (8%)

Query: 49  SAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAH 108
           S G E +D Q    +T LHLA   G+   ++ L  +GA     ++ G+  LH A   G +
Sbjct: 515 SQGAE-LDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573

Query: 109 ACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKL-Q 167
              + LL       R      L      TP      +A Y    LE     +E    +  
Sbjct: 574 LICKMLL-------RYGASLELPTHQGWTP----LHLAAY-KGHLEIIHLLAESHANMGA 621

Query: 168 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL 227
           L A N+   TPLH+A  H +  +V  L   GAD +  E + G +PLHLAV+      +  
Sbjct: 622 LGAVNW---TPLHLAARHGEEAVVSALLQCGADPNAAEQS-GWTPLHLAVQRSTFLSVIN 677

Query: 228 LLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           LL   AN  AR   G TP   A L+ N  + ++L   GA
Sbjct: 678 LLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA 716



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 35/93 (37%), Positives = 47/93 (50%), Gaps = 1/93 (1%)

Query: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233
           +G  PLH A  + D    RLL D GA +D  E   G +PLHLA +    +V  LL+   A
Sbjct: 427 DGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENVARLLVSRQA 485

Query: 234 NPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           +P      G+TPL  A    +  L +LL + GA
Sbjct: 486 DPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGA 518



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 41/125 (32%), Positives = 54/125 (43%), Gaps = 1/125 (0%)

Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236
           TPLH  V    VE VRLL     D+D  +   G +PL +A + Q  D+  LLL  GA+  
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDC-QTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 237 ARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEE 296
                G  PL  A    +   ARLL  HGA     E E   P   ++ ++  +       
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482

Query: 297 RQGSP 301
           RQ  P
Sbjct: 483 RQADP 487



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 33/102 (32%), Positives = 52/102 (50%), Gaps = 2/102 (1%)

Query: 168 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL 227
           ++A+  EG TPLH+A  +    + RLL    AD +  E   G++PLH+A       +++L
Sbjct: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAE-GKTPLHVAAYFGHVSLVKL 512

Query: 228 LLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAPE 268
           L   GA   A+    RTPL  A+ R     +  LL++   P+
Sbjct: 513 LTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPD 554



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 1/114 (0%)

Query: 165 KLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADV 224
           ++ ++ +   G+TPL +A   +  ++  LL   GAD ++ +   G +PLH A +      
Sbjct: 385 EVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDED-GWAPLHFAAQNGDDGT 443

Query: 225 LELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 278
             LLL  GA   A+   G TPL  A       +ARLL +  A     E E   P
Sbjct: 444 ARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTP 497


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 76/263 (28%), Positives = 111/263 (42%), Gaps = 35/263 (13%)

Query: 31  CRGLPSSS-----ATSLRMGTRFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAG 85
           CR L SS       +SL      SAG + ++  ++LG+T LH AA  G    +  L ++G
Sbjct: 388 CRKLLSSGQLYSIVSSLSNEHVLSAGFD-INTPDNLGRTCLHAAASGGNVECLNLLLSSG 446

Query: 86  AGLCVAERRGHTALHLACRVGAHACARALLQP------------RPRRPREAPDTYLAQG 133
           A L   ++ G T LH A   G++ CA  L+               P     A DTY    
Sbjct: 447 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE 506

Query: 134 PDRTPDTNHTPVALYPDSDLE-KEEEESEEDWKLQLEAEN--------YEGHTPLHVAVI 184
           P       HTP +   + D   KE    E  + L+   +N         +G+T +H A  
Sbjct: 507 P-------HTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAA 559

Query: 185 HKDVEMVRLLRDAGAD-LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGR 243
           + + + + LL +   + L+  E T   SPLHLA      + L+ L     N   R + GR
Sbjct: 560 YGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGR 619

Query: 244 TPLGSAMLRPNPILARLLRAHGA 266
           T L  A  R +     +L AHGA
Sbjct: 620 TALFLATERGSTECVEVLTAHGA 642



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 70/248 (28%), Positives = 93/248 (37%), Gaps = 23/248 (9%)

Query: 25  RSWARGCRGLPSSSATSLRMGTRFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 84
           R W        S    SL +        +  D+ +  GQT L LA + G    V  L   
Sbjct: 651 RKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710

Query: 85  GAGLCVAERRGHTALHLACRVGAHACARALLQPRP----RRPREAPDTYLAQGPDRTPDT 140
           G+    A+ RG TALH     G   C  ALL        R  +     +LA     T   
Sbjct: 711 GSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVL 770

Query: 141 NHTPVALYPDSDLEKEEEES-------------EEDWKLQLEAENY---EGH--TPLHVA 182
                A      L+   + S             E+  +L LE   +   EG+  TPLH A
Sbjct: 771 RTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCA 830

Query: 183 VI-HKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
           VI ++D     LL   GA +       GR+PLH A  A     L +LL+  A   A  + 
Sbjct: 831 VINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT 890

Query: 242 GRTPLGSA 249
           GRT L +A
Sbjct: 891 GRTALMTA 898



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 51/190 (26%), Positives = 81/190 (42%), Gaps = 14/190 (7%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G   LH AA  G+   V+ L   GA +      G+TALH+AC +G  A A  L+      
Sbjct: 206 GYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVN----- 260

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
                        ++  D   TP+ +   S       E   +    +  ++ EG +PLH+
Sbjct: 261 --------AGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHM 312

Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
           A IH      ++L   G+++D  +   G +PLH+A       ++  L+  GA+ A R   
Sbjct: 313 AAIHGRFTRSQILIQNGSEIDCAD-KFGNTPLHVAARYGHELLISTLMTNGADTARRGIH 371

Query: 242 GRTPLGSAML 251
              PL  A+L
Sbjct: 372 DMFPLHLAVL 381



 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 64/236 (27%), Positives = 106/236 (44%), Gaps = 29/236 (12%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           ++ ++ L QT LH+AA    T   E L    + L VA+R G +ALH A   G       L
Sbjct: 100 VNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLL 159

Query: 115 LQP---------RPRRPR---------EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKE 156
           L           + R+P          E     +A+G D           L+  +   + 
Sbjct: 160 LNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQI 219

Query: 157 EEESEEDWKLQLEAE----NYEGHTPLHVAV-IHKDVEMVRLLRDAGADLDKPEPTCGRS 211
           E      + L++ AE    N  G+T LH+A  + +D   + L+ +AGA++++P    G +
Sbjct: 220 EVVK---YLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV-NAGANVNQPNDK-GFT 274

Query: 212 PLHLA-VEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           PLH+A V    A  LELL+  GA+   +   G++PL  A +      +++L  +G+
Sbjct: 275 PLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGS 330



 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 62/233 (26%), Positives = 96/233 (41%), Gaps = 30/233 (12%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
           ++ Q+  G++ LH+AAI G  +  + L   G+ +  A++ G+T LH+A R G       L
Sbjct: 299 VNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358

Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 174
           +           DT      D  P   H  V L+  SD  ++   S + + +     N  
Sbjct: 359 MT-------NGADTARRGIHDMFP--LHLAV-LFGFSDCCRKLLSSGQLYSIVSSLSNE- 407

Query: 175 GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
                HV               AG D++ P+   GR+ LH A      + L LLL +GA+
Sbjct: 408 -----HVL-------------SAGFDINTPD-NLGRTCLHAAASGGNVECLNLLLSSGAD 448

Query: 235 PAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDS 287
              R   GRTPL  A    +   A  L   GA   E + +   P   ++ SD+
Sbjct: 449 LRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDT 501



 Score = 48.5 bits (114), Expect = 7e-06
 Identities = 57/218 (26%), Positives = 82/218 (37%), Gaps = 49/218 (22%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAER-RGHTALHLACRVGAHACARA 113
           +D+++  G+TAL LA   G T  VE L A GA   + ER R  T LH A   G       
Sbjct: 611 LDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 670

Query: 114 LLQPRPRRP-REAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
           L+    R    +  D Y                                           
Sbjct: 671 LIDSGERADITDVMDAY------------------------------------------- 687

Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232
             G TPL +A+++  V+ V LL + G+  D  +   GR+ LH        D L  LL   
Sbjct: 688 --GQTPLMLAIMNGHVDCVHLLLEKGSTADAAD-LRGRTALHRGAVTGCEDCLAALLDHD 744

Query: 233 ANPAARMYGGRTPLG-SAMLRPNPILARLLRAHGAPEP 269
           A    R + GRTP+  ++      +L  LL+A  + +P
Sbjct: 745 AFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDP 782



 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 46/177 (25%), Positives = 75/177 (42%), Gaps = 22/177 (12%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGL----CVAERRGHTALHLACRVGAHACARALLQP 117
           G+T +HLA+  G T+ +  L  A           +  G++ +H A   G   C   LL+ 
Sbjct: 754 GRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE- 812

Query: 118 RPRRPREAPDTYLAQGPDRTPDTNHTPV--ALYPDSDLEKEEEESEEDWKLQLEAENYEG 175
                  +P +YL   P        TP+  A+  + D   E        K+ + + + +G
Sbjct: 813 ------HSPFSYLEGNP-------FTPLHCAVINNQDSTTEMLLGALGAKI-VNSRDAKG 858

Query: 176 HTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232
            TPLH A    +V  +R+L    A+++  + T GR+ L  A E      +E LL  G
Sbjct: 859 RTPLHAAAFADNVSGLRMLLQHQAEVNATDHT-GRTALMTAAENGQTAAVEFLLYRG 914



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 31/81 (38%), Positives = 41/81 (50%), Gaps = 4/81 (4%)

Query: 36  SSSATSLRMGTRFSAGTEYMDLQNDLGQTALHLAAILGETSTVE-KLYAAGAGLCVAERR 94
           + + + LRM  +  A     D     G+TAL  AA  G+T+ VE  LY   A L V +  
Sbjct: 868 ADNVSGLRMLLQHQAEVNATD---HTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDEN 924

Query: 95  GHTALHLACRVGAHACARALL 115
            +TALHLAC  G   CA  +L
Sbjct: 925 KNTALHLACSKGHEKCALMIL 945



 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 32/89 (35%), Positives = 44/89 (49%), Gaps = 1/89 (1%)

Query: 178 PLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAA 237
           PL  A+  +DVE VR L     +++  +    R+PLH A       +L+LLL +GAN  A
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQE-RRTPLHAAAYVGDVPILQLLLMSGANVNA 69

Query: 238 RMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           +     TPL  A    N  +  LL AH A
Sbjct: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSA 98



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 32/91 (35%), Positives = 47/91 (51%), Gaps = 1/91 (1%)

Query: 156 EEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHL 215
           EE  S    K  +   + E  TPLH A    DV +++LL  +GA+++  + T   +PLH 
Sbjct: 22  EEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD-TLWLTPLHR 80

Query: 216 AVEAQAADVLELLLRAGANPAARMYGGRTPL 246
           A  ++   VL LLL   A+  AR    +TPL
Sbjct: 81  AAASRNEKVLGLLLAHSADVNARDKLWQTPL 111



 Score = 37.4 bits (85), Expect = 0.017
 Identities = 48/186 (25%), Positives = 67/186 (36%), Gaps = 17/186 (9%)

Query: 64  TALHLAAILGETSTVEKLYAAGAGLCVAER--RGHTALHLACRVGAHACARALLQPRPRR 121
           T LH A I  + ST E L  A     V  R  +G T LH A      +  R LLQ +   
Sbjct: 825 TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAE- 883

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
                        + T  T  T +    ++      E      K  L   +   +T LH+
Sbjct: 884 ------------VNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHL 931

Query: 182 AVI--HKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARM 239
           A    H+   ++ L       L     +  + PLH+A     A V++ LL  GA   A  
Sbjct: 932 ACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVD 991

Query: 240 YGGRTP 245
             G TP
Sbjct: 992 EEGHTP 997



 Score = 36.6 bits (83), Expect = 0.029
 Identities = 46/193 (23%), Positives = 72/193 (37%), Gaps = 17/193 (8%)

Query: 78  VEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRT 137
           +E L   GA   + +R+G+TA+H A   G       LL+       +   T         
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592

Query: 138 PDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDA 197
               H             E  ++  +  + L+  +++G T L +A      E V +L   
Sbjct: 593 AYNGHC------------EALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAH 640

Query: 198 GADLDKPEPTCGRSPLHLAVEAQAADVLELLL----RAGANPAARMYGGRTPLGSAMLRP 253
           GA     E     +PLH A  +   D L LL+    RA        Y G+TPL  A++  
Sbjct: 641 GASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAY-GQTPLMLAIMNG 699

Query: 254 NPILARLLRAHGA 266
           +     LL   G+
Sbjct: 700 HVDCVHLLLEKGS 712



 Score = 31.6 bits (70), Expect = 0.92
 Identities = 24/70 (34%), Positives = 32/70 (45%), Gaps = 4/70 (5%)

Query: 59   NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVG---AHACARALL 115
            N   Q  LH+AA  G  S V+ L + GA +   +  GHT   LAC      A   A  L 
Sbjct: 958  NSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPA-LACAPNKDVADCLALILS 1016

Query: 116  QPRPRRPREA 125
              +P  P++A
Sbjct: 1017 TMKPFPPKDA 1026


>gi|52486251 phospholipase A2, group VI isoform b [Homo sapiens]
          Length = 752

 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 65/214 (30%), Positives = 94/214 (43%), Gaps = 20/214 (9%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYA--AGAGLCVAERRGHTALHLACRVGAHACAR 112
           MD+ +  G+T  H A + G+ S V +L    A AGL     +G T LHLAC++G     R
Sbjct: 179 MDVTDYKGETVFHYA-VQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVR 237

Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
            LL    R     P+ Y      +        + +  DS             ++  +   
Sbjct: 238 VLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSS------------QIHSKDPR 285

Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232
           Y G +PLH A   K+ EM R+L   G +++    + G + LH+AV     D   +LL  G
Sbjct: 286 Y-GASPLHWA---KNAEMARMLLKRGCNVNSTS-SAGNTALHVAVMRNRFDCAIVLLTHG 340

Query: 233 ANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           AN  AR   G TPL  AM + N  + + L   GA
Sbjct: 341 ANADARGEHGNTPLHLAMSKDNVEMIKALIVFGA 374



 Score = 41.6 bits (96), Expect = 9e-04
 Identities = 50/191 (26%), Positives = 81/191 (42%), Gaps = 26/191 (13%)

Query: 59  NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115
           N+ G T LHLA  LG+   V  L    A   +    G+  +H A +     CA  ++   
Sbjct: 217 NNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEMIISMD 275

Query: 116 --QPRPRRPRE-APDTYLAQGPD-------RTPDTNHTPVALYPDSDLEKEEEESEEDWK 165
             Q   + PR  A   + A+  +       R  + N T  A   ++ L      +  D  
Sbjct: 276 SSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSA--GNTALHVAVMRNRFDCA 333

Query: 166 LQL-------EAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLA-- 216
           + L       +A    G+TPLH+A+   +VEM++ L   GA++D P    G +P  LA  
Sbjct: 334 IVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPN-DFGETPTFLASK 392

Query: 217 VEAQAADVLEL 227
           +  Q  D++ +
Sbjct: 393 IGRQLQDLMHI 403



 Score = 36.6 bits (83), Expect = 0.029
 Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 7/96 (7%)

Query: 170 AENYEGHTPLHVAVIHKDVE-MVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELL 228
           AEN EG TPLH+A    D E +V L++     +D  +   G +  H AV+   + VL+LL
Sbjct: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYK-GETVFHYAVQGDNSQVLQLL 205

Query: 229 LR---AGANPAARMYGGRTPLGSAMLRPNPILARLL 261
            R   AG N       G TPL  A       + R+L
Sbjct: 206 GRNAVAGLNQVNNQ--GLTPLHLACQLGKQEMVRVL 239



 Score = 35.4 bits (80), Expect = 0.064
 Identities = 50/222 (22%), Positives = 80/222 (36%), Gaps = 49/222 (22%)

Query: 57  LQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQ 116
           ++N    +  HLA  LG               C     G T LHLACR G       L+Q
Sbjct: 114 IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQ 173

Query: 117 PRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176
                                    HT                       Q++  +Y+G 
Sbjct: 174 -----------------------YCHT-----------------------QMDVTDYKGE 187

Query: 177 TPLHVAVIHKDVEMVRLL-RDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANP 235
           T  H AV   + ++++LL R+A A L++     G +PLHLA +    +++ +LL   A  
Sbjct: 188 TVFHYAVQGDNSQVLQLLGRNAVAGLNQVN-NQGLTPLHLACQLGKQEMVRVLLLCNAR- 245

Query: 236 AARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSG 277
              M     P+ SAM       A ++ +  + +   +D + G
Sbjct: 246 CNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYG 287



 Score = 28.5 bits (62), Expect = 7.8
 Identities = 26/89 (29%), Positives = 36/89 (40%), Gaps = 11/89 (12%)

Query: 29  RGCRGLPSSSA--TSLR---MGTRFSAGTEYM------DLQNDLGQTALHLAAILGETST 77
           RGC    +SSA  T+L    M  RF      +      D + + G T LHLA        
Sbjct: 306 RGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEM 365

Query: 78  VEKLYAAGAGLCVAERRGHTALHLACRVG 106
           ++ L   GA +      G T   LA ++G
Sbjct: 366 IKALIVFGAEVDTPNDFGETPTFLASKIG 394


>gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens]
          Length = 806

 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 65/214 (30%), Positives = 94/214 (43%), Gaps = 20/214 (9%)

Query: 55  MDLQNDLGQTALHLAAILGETSTVEKLYA--AGAGLCVAERRGHTALHLACRVGAHACAR 112
           MD+ +  G+T  H A + G+ S V +L    A AGL     +G T LHLAC++G     R
Sbjct: 179 MDVTDYKGETVFHYA-VQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVR 237

Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
            LL    R     P+ Y      +        + +  DS             ++  +   
Sbjct: 238 VLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSS------------QIHSKDPR 285

Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232
           Y G +PLH A   K+ EM R+L   G +++    + G + LH+AV     D   +LL  G
Sbjct: 286 Y-GASPLHWA---KNAEMARMLLKRGCNVNSTS-SAGNTALHVAVMRNRFDCAIVLLTHG 340

Query: 233 ANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
           AN  AR   G TPL  AM + N  + + L   GA
Sbjct: 341 ANADARGEHGNTPLHLAMSKDNVEMIKALIVFGA 374



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 48/178 (26%), Positives = 75/178 (42%), Gaps = 24/178 (13%)

Query: 59  NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115
           N+ G T LHLA  LG+   V  L    A   +    G+  +H A +     CA  ++   
Sbjct: 217 NNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEMIISMD 275

Query: 116 --QPRPRRPRE-APDTYLAQGPD-------RTPDTNHTPVALYPDSDLEKEEEESEEDWK 165
             Q   + PR  A   + A+  +       R  + N T  A   ++ L      +  D  
Sbjct: 276 SSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSA--GNTALHVAVMRNRFDCA 333

Query: 166 LQL-------EAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLA 216
           + L       +A    G+TPLH+A+   +VEM++ L   GA++D P    G +P  LA
Sbjct: 334 IVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPN-DFGETPTFLA 390



 Score = 36.6 bits (83), Expect = 0.029
 Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 7/96 (7%)

Query: 170 AENYEGHTPLHVAVIHKDVE-MVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELL 228
           AEN EG TPLH+A    D E +V L++     +D  +   G +  H AV+   + VL+LL
Sbjct: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYK-GETVFHYAVQGDNSQVLQLL 205

Query: 229 LR---AGANPAARMYGGRTPLGSAMLRPNPILARLL 261
            R   AG N       G TPL  A       + R+L
Sbjct: 206 GRNAVAGLNQVNNQ--GLTPLHLACQLGKQEMVRVL 239



 Score = 35.4 bits (80), Expect = 0.064
 Identities = 50/222 (22%), Positives = 80/222 (36%), Gaps = 49/222 (22%)

Query: 57  LQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQ 116
           ++N    +  HLA  LG               C     G T LHLACR G       L+Q
Sbjct: 114 IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQ 173

Query: 117 PRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176
                                    HT                       Q++  +Y+G 
Sbjct: 174 -----------------------YCHT-----------------------QMDVTDYKGE 187

Query: 177 TPLHVAVIHKDVEMVRLL-RDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANP 235
           T  H AV   + ++++LL R+A A L++     G +PLHLA +    +++ +LL   A  
Sbjct: 188 TVFHYAVQGDNSQVLQLLGRNAVAGLNQVN-NQGLTPLHLACQLGKQEMVRVLLLCNAR- 245

Query: 236 AARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSG 277
              M     P+ SAM       A ++ +  + +   +D + G
Sbjct: 246 CNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYG 287



 Score = 30.8 bits (68), Expect = 1.6
 Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 11/98 (11%)

Query: 29  RGCRGLPSSSA--TSLR---MGTRFSAGTEYM------DLQNDLGQTALHLAAILGETST 77
           RGC    +SSA  T+L    M  RF      +      D + + G T LHLA        
Sbjct: 306 RGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEM 365

Query: 78  VEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           ++ L   GA +      G T   LA ++G     +A+L
Sbjct: 366 IKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAIL 403


>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
          Length = 951

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 62/239 (25%), Positives = 105/239 (43%), Gaps = 23/239 (9%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G+TA HLAA  G    +  +   G  +   +  GH+ALHLA +   H C R LLQ     
Sbjct: 53  GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ----- 107

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
                    ++ P  + D++      Y  +    +  +   + K  +  ++ +G+ PL +
Sbjct: 108 ---------SKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 158

Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
           AV +   E+   L D GAD++    + GR+ L LA E  +++ +E L++ GA+       
Sbjct: 159 AVQNGHSEICHFLLDHGADVNSRNKS-GRTALMLACEIGSSNAVEALIKKGADLNLVDSL 217

Query: 242 GRTPLGSAMLRPNPILARLLRAHGAPE--------PEGEDEKSGPCSSSSDSDSGDEGV 292
           G   L  + L  N  +  LL +  + +        P+   + S P S +S   SG E V
Sbjct: 218 GYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKESV 276



 Score = 37.7 bits (86), Expect = 0.013
 Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 10/90 (11%)

Query: 58  QNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQP 117
           +N  G+TAL LA  +G ++ VE L   GA L + +  G+ ALH + ++  +A  ++LL  
Sbjct: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS-KLSENAGIQSLLLS 239

Query: 118 R---------PRRPREAPDTYLAQGPDRTP 138
           +         P +P++  D    +    TP
Sbjct: 240 KISQDADLKTPTKPKQLSDVSSPRSITSTP 269



 Score = 37.4 bits (85), Expect = 0.017
 Identities = 41/164 (25%), Positives = 67/164 (40%), Gaps = 19/164 (11%)

Query: 85  GAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPD--TNH 142
           GA     +  G TA HLA   G   C R +               +  G D T    T H
Sbjct: 43  GASATKHDSEGKTAFHLAAAKGHVECLRVM---------------ITHGVDVTAQDTTGH 87

Query: 143 TPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLD 202
           + + L   +   +   +  +  K   E+ +  G T LH A     ++ V++L +  + ++
Sbjct: 88  SALHLAAKNSHHECIRKLLQS-KCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPIN 146

Query: 203 KPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 246
             +   G  PL LAV+   +++   LL  GA+  +R   GRT L
Sbjct: 147 LKD-LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189


>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
          Length = 983

 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 54/229 (23%), Positives = 106/229 (46%), Gaps = 22/229 (9%)

Query: 8   WAPWVRTQRPPEDLGWARSWARGCRGLPSSSATSLR--MGTRFSAGTEYMDLQNDLGQTA 65
           + PW+  +    +  W ++  R  + + +  A  +   +G + ++ T++    +  G+TA
Sbjct: 5   YLPWLSAKEKKTN-EWNKNDDRLLQAVENGDAEKVASLLGKKGASATKH----DSEGKTA 59

Query: 66  LHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREA 125
            HLAA  G    +  +   G  +   +  GH+ALHLA +   H C R LLQ         
Sbjct: 60  FHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ--------- 110

Query: 126 PDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIH 185
                ++ P  + D++      Y  +    +  +   + K  +  ++ +G+ PL +AV +
Sbjct: 111 -----SKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQN 165

Query: 186 KDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
              E+   L D GAD++    + GR+ L LA E  +++ +E L++ GA+
Sbjct: 166 GHSEICHFLLDHGADVNSRNKS-GRTALMLACEIGSSNAVEALIKKGAD 213



 Score = 35.8 bits (81), Expect = 0.049
 Identities = 21/58 (36%), Positives = 35/58 (60%), Gaps = 1/58 (1%)

Query: 58  QNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           +N  G+TAL LA  +G ++ VE L   GA L + +  G+ ALH + ++  +A  ++LL
Sbjct: 184 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS-KLSENAGIQSLL 240



 Score = 35.0 bits (79), Expect = 0.083
 Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 1/94 (1%)

Query: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233
           EG T  H+A     VE +R++   G D+   + T G S LHLA +    + +  LL++  
Sbjct: 55  EGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT-GHSALHLAAKNSHHECIRKLLQSKC 113

Query: 234 NPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
              +    G+T L  A  +      ++L  H +P
Sbjct: 114 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 147


>gi|55770876 notch4 preproprotein [Homo sapiens]
          Length = 2003

 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 67/207 (32%), Positives = 86/207 (41%), Gaps = 14/207 (6%)

Query: 62   GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
            G+T LHLAA     +   +L  AGA     +R G T LH A    A    + LL+ R   
Sbjct: 1634 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSR--- 1690

Query: 122  PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
             + A D        RT D   TP+ L     +E   EE     +  + A +  G T LH 
Sbjct: 1691 -QTAVDA-------RTED-GTTPLMLAARLAVEDLVEELIAA-QADVGARDKWGKTALHW 1740

Query: 182  AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
            A    +    R L  AGAD D  +    ++PL LA    A +V +LLL  GA    R   
Sbjct: 1741 AAAVNNARAARSLLQAGADKD-AQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQA 1799

Query: 242  GRTPLGSAMLRPNPILARLLRAHGAPE 268
            G  P   A  R +  L  LL   G PE
Sbjct: 1800 GLAPADVAHQRNHWDLLTLLEGAGPPE 1826



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 33/104 (31%), Positives = 46/104 (44%)

Query: 175  GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
            G TPLH AV     E+ +LL  +           G +PL LA      D++E L+ A A+
Sbjct: 1667 GRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQAD 1726

Query: 235  PAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 278
              AR   G+T L  A    N   AR L   GA +   ++ +  P
Sbjct: 1727 VGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTP 1770



 Score = 41.6 bits (96), Expect = 9e-04
 Identities = 51/184 (27%), Positives = 72/184 (39%), Gaps = 49/184 (26%)

Query: 55   MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
            +D + + G T L LAA L     VE+L AA A +   ++ G TALH A  V     AR+L
Sbjct: 1694 VDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSL 1753

Query: 115  LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 174
            LQ                G D+                                +A++  
Sbjct: 1754 LQ---------------AGADK--------------------------------DAQDNR 1766

Query: 175  GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
              TPL +A     VE+ +LL   GA  +  +   G +P  +A +    D+L LL  AG  
Sbjct: 1767 EQTPLFLAAREGAVEVAQLLLGLGAARELRD-QAGLAPADVAHQRNHWDLLTLLEGAGP- 1824

Query: 235  PAAR 238
            P AR
Sbjct: 1825 PEAR 1828



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 38/118 (32%), Positives = 49/118 (41%), Gaps = 20/118 (16%)

Query: 149  PDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEP-- 206
            P + +    +ESE +    L+    +G TPL  AV   +V+        GA L  PEP  
Sbjct: 1562 PQAAMLTPPQESEMEAP-DLDTRGPDGVTPLMSAVCCGEVQSGTF---QGAWLGCPEPWE 1617

Query: 207  ------TC--------GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAM 250
                   C        G +PLHLA           LL AGANP      GRTPL +A+
Sbjct: 1618 PLLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAV 1675


>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
          Length = 972

 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 47/173 (27%), Positives = 82/173 (47%), Gaps = 15/173 (8%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G+TA HLAA  G    +  +   G  +   +  GH+ALHLA +   H C R LLQ     
Sbjct: 45  GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ----- 99

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
                    ++ P  + D++      Y  +    +  +   + K  +  ++ +G+ PL +
Sbjct: 100 ---------SKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 150

Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
           AV +   E+   L D GAD++    + GR+ L LA E  +++ +E L++ GA+
Sbjct: 151 AVQNGHSEICHFLLDHGADVNSRNKS-GRTALMLACEIGSSNAVEALIKKGAD 202



 Score = 35.8 bits (81), Expect = 0.049
 Identities = 21/58 (36%), Positives = 35/58 (60%), Gaps = 1/58 (1%)

Query: 58  QNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           +N  G+TAL LA  +G ++ VE L   GA L + +  G+ ALH + ++  +A  ++LL
Sbjct: 173 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS-KLSENAGIQSLL 229



 Score = 35.0 bits (79), Expect = 0.083
 Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 1/94 (1%)

Query: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233
           EG T  H+A     VE +R++   G D+   + T G S LHLA +    + +  LL++  
Sbjct: 44  EGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT-GHSALHLAAKNSHHECIRKLLQSKC 102

Query: 234 NPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
              +    G+T L  A  +      ++L  H +P
Sbjct: 103 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 136


>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 47/173 (27%), Positives = 82/173 (47%), Gaps = 15/173 (8%)

Query: 62  GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
           G+TA HLAA  G    +  +   G  +   +  GH+ALHLA +   H C R LLQ     
Sbjct: 53  GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ----- 107

Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
                    ++ P  + D++      Y  +    +  +   + K  +  ++ +G+ PL +
Sbjct: 108 ---------SKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 158

Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
           AV +   E+   L D GAD++    + GR+ L LA E  +++ +E L++ GA+
Sbjct: 159 AVQNGHSEICHFLLDHGADVNSRNKS-GRTALMLACEIGSSNAVEALIKKGAD 210



 Score = 35.8 bits (81), Expect = 0.049
 Identities = 21/58 (36%), Positives = 35/58 (60%), Gaps = 1/58 (1%)

Query: 58  QNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
           +N  G+TAL LA  +G ++ VE L   GA L + +  G+ ALH + ++  +A  ++LL
Sbjct: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS-KLSENAGIQSLL 237



 Score = 35.0 bits (79), Expect = 0.083
 Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 1/94 (1%)

Query: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233
           EG T  H+A     VE +R++   G D+   + T G S LHLA +    + +  LL++  
Sbjct: 52  EGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT-GHSALHLAAKNSHHECIRKLLQSKC 110

Query: 234 NPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
              +    G+T L  A  +      ++L  H +P
Sbjct: 111 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 144


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.131    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,566,283
Number of Sequences: 37866
Number of extensions: 796723
Number of successful extensions: 7525
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 334
Number of HSP's successfully gapped in prelim test: 100
Number of HSP's that attempted gapping in prelim test: 4135
Number of HSP's gapped (non-prelim): 2094
length of query: 306
length of database: 18,247,518
effective HSP length: 102
effective length of query: 204
effective length of database: 14,385,186
effective search space: 2934577944
effective search space used: 2934577944
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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