BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|48928017 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta isoform b [Homo sapiens] (306 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|48928017 nuclear factor of kappa light polypeptide gene enhan... 627 e-180 gi|21361135 nuclear factor of kappa light polypeptide gene enhan... 497 e-141 gi|71274109 nuclear factor of kappa light polypeptide gene enhan... 113 2e-25 gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens] 107 1e-23 gi|117320531 nuclear factor of kappa light polypeptide gene enha... 102 6e-22 gi|117320540 nuclear factor of kappa light polypeptide gene enha... 102 6e-22 gi|117320527 nuclear factor of kappa light polypeptide gene enha... 102 6e-22 gi|10092619 nuclear factor of kappa light polypeptide gene enhan... 98 1e-20 gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens] 82 6e-16 gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 75 7e-14 gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 73 3e-13 gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 73 3e-13 gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 73 3e-13 gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 72 6e-13 gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 72 6e-13 gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 72 6e-13 gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 72 6e-13 gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 72 6e-13 gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 71 1e-12 gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 71 1e-12 gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3... 71 1e-12 gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 70 2e-12 gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 70 2e-12 gi|52486251 phospholipase A2, group VI isoform b [Homo sapiens] 69 4e-12 gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens] 69 4e-12 gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 67 3e-11 gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 66 4e-11 gi|55770876 notch4 preproprotein [Homo sapiens] 65 6e-11 gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 65 6e-11 gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 65 6e-11 >gi|48928017 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta isoform b [Homo sapiens] Length = 306 Score = 627 bits (1617), Expect = e-180 Identities = 306/306 (100%), Positives = 306/306 (100%) Query: 1 MNGATAAWAPWVRTQRPPEDLGWARSWARGCRGLPSSSATSLRMGTRFSAGTEYMDLQND 60 MNGATAAWAPWVRTQRPPEDLGWARSWARGCRGLPSSSATSLRMGTRFSAGTEYMDLQND Sbjct: 1 MNGATAAWAPWVRTQRPPEDLGWARSWARGCRGLPSSSATSLRMGTRFSAGTEYMDLQND 60 Query: 61 LGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPR 120 LGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPR Sbjct: 61 LGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPR 120 Query: 121 RPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLH 180 RPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLH Sbjct: 121 RPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLH 180 Query: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY Sbjct: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240 Query: 241 GGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGS 300 GGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGS Sbjct: 241 GGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGS 300 Query: 301 PAGGSG 306 PAGGSG Sbjct: 301 PAGGSG 306 >gi|21361135 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta isoform a [Homo sapiens] Length = 356 Score = 497 bits (1279), Expect = e-141 Identities = 244/244 (100%), Positives = 244/244 (100%) Query: 48 FSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGA 107 FSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGA Sbjct: 80 FSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGA 139 Query: 108 HACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQ 167 HACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQ Sbjct: 140 HACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQ 199 Query: 168 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL 227 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL Sbjct: 200 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL 259 Query: 228 LLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDS 287 LLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDS Sbjct: 260 LLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDS 319 Query: 288 GDEG 291 GDEG Sbjct: 320 GDEG 323 Score = 34.7 bits (78), Expect = 0.11 Identities = 39/143 (27%), Positives = 52/143 (36%), Gaps = 25/143 (17%) Query: 174 EGHTPLHVAVIHKDVEMVRLLR--DAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231 +G T LH+AVIH+ + L AG + + G++ LHLA +E L A Sbjct: 57 DGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 116 Query: 232 GANPAARMYGGRTPL-----------GSAMLRPNPILARLLRAHGAPE-------PEGED 273 GA G T L A+L+P P R AP+ D Sbjct: 117 GAGLCVAERRGHTALHLACRVGAHACARALLQPRP-----RRPREAPDTYLAQGPDRTPD 171 Query: 274 EKSGPCSSSSDSDSGDEGVSQEE 296 P + DSD E EE Sbjct: 172 TNHTPVALYPDSDLEKEEEESEE 194 >gi|71274109 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon [Homo sapiens] Length = 500 Score = 113 bits (282), Expect = 2e-25 Identities = 72/194 (37%), Positives = 99/194 (51%), Gaps = 37/194 (19%) Query: 53 EYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACAR 112 E +D+QN+L QTALHLA L + V L GA + +R G TALH+AC+ ACAR Sbjct: 285 EVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACAR 344 Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172 LL+ RP R T+H+ L L+ +N Sbjct: 345 CLLEGRPEPGR---------------GTSHS----------------------LDLQLQN 367 Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232 ++G LH+A + K+ ++ LL GAD+D E T G++ LHLAVE Q +++ LL+AG Sbjct: 368 WQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAG 427 Query: 233 ANPAARMYGGRTPL 246 A ARM G TPL Sbjct: 428 AQVDARMLNGCTPL 441 Score = 35.8 bits (81), Expect = 0.049 Identities = 36/110 (32%), Positives = 50/110 (45%), Gaps = 11/110 (10%) Query: 167 QLEAENY---EGHTPLHVAVIHKDVEMV----RLLRDAGADLDKPEPTCGRSPLHLAVEA 219 QLEA Y +G T +H+AVIH+ ++ LL D+ ++ LHLAV Sbjct: 248 QLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQN---NLYQTALHLAVHL 304 Query: 220 QAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEP 269 + L+ GA+ A + G T L A R + AR L G PEP Sbjct: 305 DQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCL-LEGRPEP 353 >gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens] Length = 454 Score = 107 bits (268), Expect = 1e-23 Identities = 83/224 (37%), Positives = 102/224 (45%), Gaps = 43/224 (19%) Query: 43 RMGTRFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLA 102 R+ F G +D+ N+L QT LHLA I S V L AGA +R G TA HLA Sbjct: 153 RLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLA 212 Query: 103 CRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEE 162 C + C RALL AP T Sbjct: 213 CEHRSPTCLRALLDSA------APGT---------------------------------- 232 Query: 163 DWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAA 222 L LEA NY+G T LHVAV + E V+LL + GAD+D + GRSPL AVE + Sbjct: 233 ---LDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSL 289 Query: 223 DVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 +++LLL+ GAN A+MY G + L SA R L R L GA Sbjct: 290 SMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGA 333 Score = 49.3 bits (116), Expect = 4e-06 Identities = 34/98 (34%), Positives = 49/98 (50%), Gaps = 5/98 (5%) Query: 174 EGHTPLHVAVIHKDV----EMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLL 229 +G TPLH+AV+ ++ +V L + G +LD ++PLHLAV V+ LL+ Sbjct: 134 DGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYN-NLRQTPLHLAVITTLPSVVRLLV 192 Query: 230 RAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267 AGA+P A G+T A +P R L AP Sbjct: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAP 230 >gi|117320531 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 isoform a [Homo sapiens] Length = 900 Score = 102 bits (253), Expect = 6e-22 Identities = 85/248 (34%), Positives = 111/248 (44%), Gaps = 47/248 (18%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHA--CAR 112 ++L N L QT LHLA I G+TS V L GA + +R G +A+HLA R GA A R Sbjct: 520 VNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLR 579 Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172 ALLQ G P H P + Sbjct: 580 ALLQ---------------SGAPAVPQLLHMP---------------------------D 597 Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAAD-VLELLLRA 231 +EG P+H+AV + E + LL D+GA+++ E GR+ LHLA E + V L+ + Sbjct: 598 FEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKL 657 Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSS--SSDSDSGD 289 AN AR + G TPL A P L RLL GA +E P S +SDSDS Sbjct: 658 RANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDS 717 Query: 290 EGVSQEER 297 EG ++ R Sbjct: 718 EGPEKDTR 725 Score = 45.4 bits (106), Expect = 6e-05 Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 7/107 (6%) Query: 168 LEAENYEGHTPLHVAVIHKD---VEMVRLLRDAGADLDKPEPT--CGRSPLHLAVEAQAA 222 L A++ G TPLH+A+IH +E + + DL T ++PLHLAV Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540 Query: 223 DVLELLLRAGANPAARMYGGRTPLGSAML--RPNPILARLLRAHGAP 267 V+ LLR GA+PA G + + A+ P L R L GAP Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP 587 Score = 43.5 bits (101), Expect = 2e-04 Identities = 75/286 (26%), Positives = 105/286 (36%), Gaps = 58/286 (20%) Query: 50 AGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA-AGAGLCVAERRGHTALHLACRVGAH 108 +G E + G+TALHLA + E V L A + G+T LHLA +G Sbjct: 622 SGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYP 681 Query: 109 ACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH--TPVALYPDSDLEKEEEESEEDWKL 166 R LL+ G D + P+ P SD + + E E+D + Sbjct: 682 TLTRLLLK---------------AGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTR- 725 Query: 167 QLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPL--HLAVEAQAADV 224 ++ GHTPL + ++ LL +A + +P P SP L++ A Sbjct: 726 ----SSFRGHTPLDLTC---STKVKTLLLNAAQNTMEP-PLTPPSPAGPGLSLGDTALQN 777 Query: 225 LELLL--------------RAGANPAARMYGGRTPLGSAMLRPNPI----LARLLRA--- 263 LE LL R G Y T ++LR + LA LL A Sbjct: 778 LEQLLDGPEAQGSWAELAERLGLRSLVDTYRQTTSPSGSLLRSYELAGGDLAGLLEALSD 837 Query: 264 HGAPE-------PEGEDEKSGPCSSSSDSDSGDEGVSQE-ERQGSP 301 G E PE D+ DS G + V QE E+ G P Sbjct: 838 MGLEEGVRLLRGPETRDKLPSTAEVKEDSAYGSQSVEQEAEKLGPP 883 >gi|117320540 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 isoform b [Homo sapiens] Length = 899 Score = 102 bits (253), Expect = 6e-22 Identities = 85/248 (34%), Positives = 111/248 (44%), Gaps = 47/248 (18%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHA--CAR 112 ++L N L QT LHLA I G+TS V L GA + +R G +A+HLA R GA A R Sbjct: 520 VNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLR 579 Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172 ALLQ G P H P + Sbjct: 580 ALLQ---------------SGAPAVPQLLHMP---------------------------D 597 Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAAD-VLELLLRA 231 +EG P+H+AV + E + LL D+GA+++ E GR+ LHLA E + V L+ + Sbjct: 598 FEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKL 657 Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSS--SSDSDSGD 289 AN AR + G TPL A P L RLL GA +E P S +SDSDS Sbjct: 658 RANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDS 717 Query: 290 EGVSQEER 297 EG ++ R Sbjct: 718 EGPEKDTR 725 Score = 45.4 bits (106), Expect = 6e-05 Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 7/107 (6%) Query: 168 LEAENYEGHTPLHVAVIHKD---VEMVRLLRDAGADLDKPEPT--CGRSPLHLAVEAQAA 222 L A++ G TPLH+A+IH +E + + DL T ++PLHLAV Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540 Query: 223 DVLELLLRAGANPAARMYGGRTPLGSAML--RPNPILARLLRAHGAP 267 V+ LLR GA+PA G + + A+ P L R L GAP Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP 587 Score = 39.7 bits (91), Expect = 0.003 Identities = 76/286 (26%), Positives = 105/286 (36%), Gaps = 59/286 (20%) Query: 50 AGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA-AGAGLCVAERRGHTALHLACRVGAH 108 +G E + G+TALHLA + E V L A + G+T LHLA +G Sbjct: 622 SGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYP 681 Query: 109 ACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH--TPVALYPDSDLEKEEEESEEDWKL 166 R LL+ G D + P+ P SD + + E E+D + Sbjct: 682 TLTRLLLK---------------AGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTR- 725 Query: 167 QLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPL--HLAVEAQAADV 224 ++ GHTPL + ++ LL +A + +P P SP L++ A Sbjct: 726 ----SSFRGHTPLDLTC---STKVKTLLLNAAQNTMEP-PLTPPSPAGPGLSLGDTALQN 777 Query: 225 LELLL--------------RAGANPAARMYGGRTPLGSAMLRPNPI----LARLLRA--- 263 LE LL R G Y T ++LR + LA LL A Sbjct: 778 LEQLLDGPEAQGSWAELAERLGLRSLVDTYRQTTSPSGSLLRSYELAGGDLAGLLEALSD 837 Query: 264 HGAPE-------PEGEDEKSGPCSSSSDSDSGDEGVSQE-ERQGSP 301 G E PE D K DS G + V QE E+ G P Sbjct: 838 MGLEEGVRLLRGPETRD-KLPSTEVKEDSAYGSQSVEQEAEKLGPP 882 >gi|117320527 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 isoform b [Homo sapiens] Length = 899 Score = 102 bits (253), Expect = 6e-22 Identities = 85/248 (34%), Positives = 111/248 (44%), Gaps = 47/248 (18%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHA--CAR 112 ++L N L QT LHLA I G+TS V L GA + +R G +A+HLA R GA A R Sbjct: 520 VNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLR 579 Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172 ALLQ G P H P + Sbjct: 580 ALLQ---------------SGAPAVPQLLHMP---------------------------D 597 Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAAD-VLELLLRA 231 +EG P+H+AV + E + LL D+GA+++ E GR+ LHLA E + V L+ + Sbjct: 598 FEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKL 657 Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSS--SSDSDSGD 289 AN AR + G TPL A P L RLL GA +E P S +SDSDS Sbjct: 658 RANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDS 717 Query: 290 EGVSQEER 297 EG ++ R Sbjct: 718 EGPEKDTR 725 Score = 45.4 bits (106), Expect = 6e-05 Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 7/107 (6%) Query: 168 LEAENYEGHTPLHVAVIHKD---VEMVRLLRDAGADLDKPEPT--CGRSPLHLAVEAQAA 222 L A++ G TPLH+A+IH +E + + DL T ++PLHLAV Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540 Query: 223 DVLELLLRAGANPAARMYGGRTPLGSAML--RPNPILARLLRAHGAP 267 V+ LLR GA+PA G + + A+ P L R L GAP Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP 587 Score = 39.7 bits (91), Expect = 0.003 Identities = 76/286 (26%), Positives = 105/286 (36%), Gaps = 59/286 (20%) Query: 50 AGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA-AGAGLCVAERRGHTALHLACRVGAH 108 +G E + G+TALHLA + E V L A + G+T LHLA +G Sbjct: 622 SGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYP 681 Query: 109 ACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH--TPVALYPDSDLEKEEEESEEDWKL 166 R LL+ G D + P+ P SD + + E E+D + Sbjct: 682 TLTRLLLK---------------AGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTR- 725 Query: 167 QLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPL--HLAVEAQAADV 224 ++ GHTPL + ++ LL +A + +P P SP L++ A Sbjct: 726 ----SSFRGHTPLDLTC---STKVKTLLLNAAQNTMEP-PLTPPSPAGPGLSLGDTALQN 777 Query: 225 LELLL--------------RAGANPAARMYGGRTPLGSAMLRPNPI----LARLLRA--- 263 LE LL R G Y T ++LR + LA LL A Sbjct: 778 LEQLLDGPEAQGSWAELAERLGLRSLVDTYRQTTSPSGSLLRSYELAGGDLAGLLEALSD 837 Query: 264 HGAPE-------PEGEDEKSGPCSSSSDSDSGDEGVSQE-ERQGSP 301 G E PE D K DS G + V QE E+ G P Sbjct: 838 MGLEEGVRLLRGPETRD-KLPSTEVKEDSAYGSQSVEQEAEKLGPP 882 >gi|10092619 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [Homo sapiens] Length = 317 Score = 97.8 bits (242), Expect = 1e-20 Identities = 78/241 (32%), Positives = 104/241 (43%), Gaps = 45/241 (18%) Query: 54 YMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARA 113 +++ QN+L QT LHLA I + E L AG + + RG+T LHLAC G A Sbjct: 103 FLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGV 162 Query: 114 LLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENY 173 L Q TP + L+A NY Sbjct: 163 LTQSCT-----------------TPHLHSI------------------------LKATNY 181 Query: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233 GHT LH+A IH + +V LL GAD++ EP GR+ LHLAV+ Q D++ LLL+ GA Sbjct: 182 NGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGA 241 Query: 234 NPAARMYGGRTPL----GSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGD 289 + Y G +P G R L +L + PE EDE+S S + D Sbjct: 242 DVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTED 301 Query: 290 E 290 E Sbjct: 302 E 302 Score = 50.1 bits (118), Expect = 2e-06 Identities = 32/95 (33%), Positives = 50/95 (52%), Gaps = 6/95 (6%) Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEM-VRLLRDAGADLD--KPEPTCGRS 211 +E E WK QL + G + LH+A+IH++ + + ++R DL + ++ Sbjct: 57 QEVPRGSEPWKQQLTED---GDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQT 113 Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 246 PLHLAV ++ E LL AG +P R + G TPL Sbjct: 114 PLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPL 148 >gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens] Length = 969 Score = 82.0 bits (201), Expect = 6e-16 Identities = 73/241 (30%), Positives = 103/241 (42%), Gaps = 45/241 (18%) Query: 53 EYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACAR 112 + ++++NDL QT LHLA I + VE L AGA L + +R G++ LHLA + G Sbjct: 574 DIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLS 633 Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172 LL+ H AL L+ N Sbjct: 634 ILLK-------------------------HKKAALL-------------------LDHPN 649 Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE-LLLRA 231 +G +H+A++ + + LL AGAD++ E GR+ LHLAVE + LLL Sbjct: 650 GDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEG 709 Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEG 291 A+ + Y G TPL A R + LA LL+A GA E S ++ DEG Sbjct: 710 DAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEG 769 Query: 292 V 292 V Sbjct: 770 V 770 Score = 40.4 bits (93), Expect = 0.002 Identities = 25/69 (36%), Positives = 40/69 (57%), Gaps = 5/69 (7%) Query: 171 ENYEGHTPLHVAVIHKDVEMVRLLRDAGA-----DLDKPEPTCGRSPLHLAVEAQAADVL 225 ++ G + LH+A+IH ++VR L + + D+ ++PLHLAV + DV+ Sbjct: 540 QDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVV 599 Query: 226 ELLLRAGAN 234 E LLRAGA+ Sbjct: 600 EDLLRAGAD 608 >gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] Length = 4377 Score = 75.1 bits (183), Expect = 7e-14 Identities = 70/227 (30%), Positives = 96/227 (42%), Gaps = 26/227 (11%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T +H+AA +G + V +L GA RG TALH+A R G R L+Q + Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 492 Query: 122 PREAPD------------------TYLAQG--PDRTPDTNHTPVALYPDSDLEKEEEESE 161 +A D L QG P+ + +TP+ L S E E+ + Sbjct: 493 EAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHL---SAREGHEDVAA 549 Query: 162 --EDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEA 219 D L +G TPLHVA + +E+ LL A D + G +PLH+A Sbjct: 550 FLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKS-GLTPLHVAAHY 608 Query: 220 QAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 V LLL GA+P A G TPL A + +A L +GA Sbjct: 609 DNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGA 655 Score = 58.9 bits (141), Expect = 5e-09 Identities = 54/228 (23%), Positives = 97/228 (42%), Gaps = 16/228 (7%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 +D G TALH+A++ G+ V+ L GA + + G T L++A + + L Sbjct: 100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159 Query: 115 LQPRPRRPREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDW 164 L + D + L QG D+ + + P + +++++ Sbjct: 160 LDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAA 219 Query: 165 KL-----QLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEA 219 L + E+ G TPLH+A + ++ + LL + A +D +PLH+A + Sbjct: 220 LLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN-DITPLHVASKR 278 Query: 220 QAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267 A++++LLL GA A+ G TPL + + +L AP Sbjct: 279 GNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326 Score = 58.9 bits (141), Expect = 5e-09 Identities = 59/225 (26%), Positives = 90/225 (40%), Gaps = 22/225 (9%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPR- 120 G T LHL+A G L GA L + ++G T LH+A + G A LLQ Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP 591 Query: 121 --------RPREAPDTY---------LAQG--PDRTPDTNHTPVALYPDSDLEKEEEESE 161 P Y L QG P +TP+ + + + + + Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN-QMDIATTL 650 Query: 162 EDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQA 221 ++ A +G +H+A V+MV LL A+++ + G +PLHLA + Sbjct: 651 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS-GLTPLHLAAQEDR 709 Query: 222 ADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 +V E+L+ GA+ A+ G TPL N + L H A Sbjct: 710 VNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSA 754 Score = 51.2 bits (121), Expect = 1e-06 Identities = 49/188 (26%), Positives = 77/188 (40%), Gaps = 15/188 (7%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH+AA + L GA R+G ++HLA + G H +LL R Sbjct: 631 GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEG-HVDMVSLLLGRNAN 689 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181 + + L TP+ L D E ++A+ G+TPLHV Sbjct: 690 VNLSNKSGL------------TPLHLAAQEDRVNVAEVLVNQGA-HVDAQTKMGYTPLHV 736 Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241 + ++++V L A ++ G +PLH A + ++ +LL+ A+P Sbjct: 737 GCHYGNIKIVNFLLQHSAKVNAKTKN-GYTPLHQAAQQGHTHIINVLLQNNASPNELTVN 795 Query: 242 GRTPLGSA 249 G T LG A Sbjct: 796 GNTALGIA 803 Score = 49.7 bits (117), Expect = 3e-06 Identities = 59/232 (25%), Positives = 87/232 (37%), Gaps = 26/232 (11%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 +++ N G ALHLA+ G V +L A + A ++G+TALH+A G + L Sbjct: 67 INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126 Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 174 + ++ + + NH V + D + + ED L + Sbjct: 127 VTNGANVNAQSQNGFTPL--YMAAQENHLEVVKFL-LDNGASQSLATEDGFTPLAVALQQ 183 Query: 175 GH------------------TPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSPLH 214 GH LH+A D + LL D AD+ E G +PLH Sbjct: 184 GHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADV---ESKSGFTPLH 240 Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 +A +V LLL A TPL A R N + +LL GA Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGA 292 Score = 49.3 bits (116), Expect = 4e-06 Identities = 49/205 (23%), Positives = 75/205 (36%), Gaps = 48/205 (23%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH+A +E L GA + G T +H+A +G L+ Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM------ 453 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181 + P+ T N G T LH+ Sbjct: 454 -------HHGASPNTT----------------------------------NVRGETALHM 472 Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241 A E+VR L GA ++ + ++PLH++ AD+++ LL+ GA+P A Sbjct: 473 AARSGQAEVVRYLVQDGAQVE-AKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS 531 Query: 242 GRTPLGSAMLRPNPILARLLRAHGA 266 G TPL + + +A L HGA Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGA 556 Score = 48.5 bits (114), Expect = 7e-06 Identities = 55/223 (24%), Positives = 86/223 (38%), Gaps = 16/223 (7%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 +D + G T LH A G VE L A + + G + LH+A + C + L Sbjct: 294 IDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLL 353 Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 174 LQ D A H VA + D K A+ Sbjct: 354 LQHNVPVDDVTNDYLTALHV--AAHCGHYKVA------------KVLLDKKANPNAKALN 399 Query: 175 GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234 G TPLH+A ++++ LL GA + + G +P+H+A +++ L+ GA+ Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTES-GLTPIHVAAFMGHVNIVSQLMHHGAS 458 Query: 235 PAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDEKS 276 P G T L A + R L GA E + +D+++ Sbjct: 459 PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQT 501 Score = 47.8 bits (112), Expect = 1e-05 Identities = 51/222 (22%), Positives = 81/222 (36%), Gaps = 29/222 (13%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 D G T LH+AA L GA A + G+T LH+A + Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAK----------- 640 Query: 116 QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-------KLQL 168 + + T L G D T +++ + +E D + Sbjct: 641 ----KNQMDIATTLLEYGADANAVTRQGIASVHLAA------QEGHVDMVSLLLGRNANV 690 Query: 169 EAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELL 228 N G TPLH+A V + +L + GA +D + G +PLH+ ++ L Sbjct: 691 NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDA-QTKMGYTPLHVGCHYGNIKIVNFL 749 Query: 229 LRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPE 270 L+ A A+ G TPL A + + + +L + A E Sbjct: 750 LQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791 Score = 40.8 bits (94), Expect = 0.002 Identities = 31/97 (31%), Positives = 48/97 (49%), Gaps = 1/97 (1%) Query: 172 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231 N G LH+A VE+V L A++D G + LH+A A A+V+++L+ Sbjct: 71 NQNGLNALHLASKEGHVEVVSELLQREANVDAATKK-GNTALHIASLAGQAEVVKVLVTN 129 Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPE 268 GAN A+ G TPL A + + + L +GA + Sbjct: 130 GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ 166 Score = 37.7 bits (86), Expect = 0.013 Identities = 22/62 (35%), Positives = 29/62 (46%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 ++L N G T LHLAA + E L GA + + G+T LH+ C G L Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749 Query: 115 LQ 116 LQ Sbjct: 750 LQ 751 Score = 32.7 bits (73), Expect = 0.41 Identities = 19/63 (30%), Positives = 27/63 (42%) Query: 54 YMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARA 113 ++D Q +G T LH+ G V L A + + G+T LH A + G Sbjct: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781 Query: 114 LLQ 116 LLQ Sbjct: 782 LLQ 784 >gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] Length = 1863 Score = 73.2 bits (178), Expect = 3e-13 Identities = 66/217 (30%), Positives = 93/217 (42%), Gaps = 27/217 (12%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 D+ N G+TALH+AA G+ V L GA + R T LH+A R+G + LL Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 496 Query: 116 QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEA----- 170 Q ++A PD +TP+ + E + + LEA Sbjct: 497 Q------------HMAH-PDAATTNGYTPLHI-------SAREGQVDVASVLLEAGAAHS 536 Query: 171 -ENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLL 229 +G TPLHVA + +++ +LL A D G +PLH+A V LLL Sbjct: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLL 595 Query: 230 RAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 GA+P A G TPL A + +A L +GA Sbjct: 596 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 632 Score = 68.2 bits (165), Expect = 9e-12 Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 17/208 (8%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH++A G+ L AGA +A ++G T LH+A + G+ A+ LLQ R Sbjct: 509 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA-- 566 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES-EEDWKLQLEAENYEGHTPLH 180 D TP+ + D +K E+ A+N G+TPLH Sbjct: 567 -----------AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--GYTPLH 613 Query: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240 +A +++ L + GA+ + G +PLHLA + D++ LLL GAN Sbjct: 614 IAAKKNQMQIASTLLNYGAETNIVTKQ-GVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 672 Query: 241 GGRTPLGSAMLRPNPILARLLRAHGAPE 268 G T L A +A +L HGA + Sbjct: 673 SGLTSLHLAAQEDKVNVADILTKHGADQ 700 Score = 65.5 bits (158), Expect = 6e-11 Identities = 60/243 (24%), Positives = 98/243 (40%), Gaps = 38/243 (15%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 +D G TALH+A++ G+ V+ L GA + + G T L++A + + L Sbjct: 69 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128 Query: 115 LQPRPRRPREAPDTY------LAQGPD------------------------RTPDTNHTP 144 L+ + D + L QG + R DT Sbjct: 129 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 188 Query: 145 VALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKP 204 + L D + + + K+ + G TPLH+A + +V + LL + GA +D Sbjct: 189 LLLQNDHNADVQS-------KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 241 Query: 205 EPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAH 264 G +PLH+A + ++++LLL G A+ G TPL A + + LL Sbjct: 242 ARN-GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 300 Query: 265 GAP 267 GAP Sbjct: 301 GAP 303 Score = 60.5 bits (145), Expect = 2e-09 Identities = 64/239 (26%), Positives = 95/239 (39%), Gaps = 30/239 (12%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 ++ Q+ G T L++AA V+ L GA A G T L +A + G + L Sbjct: 102 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161 Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEE-----ESEEDWKLQLE 169 L+ + P ++A D DT + L D + + + + +E + Sbjct: 162 LENDTKGKVRLPALHIAARKD---DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 218 Query: 170 AENY---------------------EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 208 A +Y G TPLHVA + MV+LL D G +D + Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA-KTRD 277 Query: 209 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267 G +PLH A + V+ELLL GA AR G +PL A + + L H AP Sbjct: 278 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 336 Score = 55.5 bits (132), Expect = 6e-08 Identities = 63/234 (26%), Positives = 88/234 (37%), Gaps = 32/234 (13%) Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPR 118 N G ALHLAA G V++L G+ + A ++G+TALH+A G + L++ Sbjct: 40 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 99 Query: 119 PRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES--EEDWKLQLEAENYEGH 176 ++ + + NH V Y LE +S ED L +GH Sbjct: 100 ANINAQSQNGFTPL--YMAAQENHIDVVKYL---LENGANQSTATEDGFTPLAVALQQGH 154 Query: 177 T------------------PLHVAVIHKDVEMVRLL--RDAGADLDKP-----EPTCGRS 211 LH+A D + LL D AD+ G + Sbjct: 155 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 214 Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265 PLH+A +V LLL GA G TPL A R N + +LL G Sbjct: 215 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 268 Score = 53.1 bits (126), Expect = 3e-07 Identities = 63/240 (26%), Positives = 86/240 (35%), Gaps = 48/240 (20%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T +H+AA +G + V L GA V RG TALH+A R G R L Sbjct: 410 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL------- 462 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181 L G ++A E TPLH+ Sbjct: 463 --------LRNGA--------------------------------LVDARAREEQTPLHI 482 Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241 A E+V+LL A D T G +PLH++ DV +LL AGA + Sbjct: 483 ASRLGKTEIVQLLLQHMAHPDAAT-TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK 541 Query: 242 GRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGSP 301 G TPL A + +A+LL A P ++ D+ + E+ SP Sbjct: 542 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 601 Score = 51.2 bits (121), Expect = 1e-06 Identities = 53/192 (27%), Positives = 77/192 (40%), Gaps = 23/192 (11%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH+AA + L GA + ++G T LHLA + G LL Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667 Query: 122 PREAPD----TYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT 177 +LA D+ N + L K + + KL G+T Sbjct: 668 HMSTKSGLTSLHLAAQEDKV---NVADI-------LTKHGADQDAHTKL--------GYT 709 Query: 178 PLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAA 237 PL VA + +V+MV L GA+++ G +PLH A + ++ +LL+ GA P A Sbjct: 710 PLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKPNA 768 Query: 238 RMYGGRTPLGSA 249 G T L A Sbjct: 769 TTANGNTALAIA 780 Score = 49.7 bits (117), Expect = 3e-06 Identities = 65/245 (26%), Positives = 88/245 (35%), Gaps = 48/245 (19%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGL---------------------CVAER 93 +D + G T LH AA G VE L GA L CV Sbjct: 271 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 330 Query: 94 RGH------------TALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTN 141 H TALH+A G + + LL R P+ Sbjct: 331 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR-------------ANPNARALNG 377 Query: 142 HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADL 201 TP+ + + K E + + ++A G TP+HVA + +V LL GA Sbjct: 378 FTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436 Query: 202 DKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLL 261 D G + LH+A A +V+ LLR GA AR +TPL A + +LL Sbjct: 437 DVTN-IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 495 Query: 262 RAHGA 266 H A Sbjct: 496 LQHMA 500 Score = 43.1 bits (100), Expect = 3e-04 Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 1/107 (0%) Query: 172 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231 N G LH+A V +V+ L G+ +D G + LH+A A A+V+++L++ Sbjct: 40 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-GNTALHIASLAGQAEVVKVLVKE 98 Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 278 GAN A+ G TPL A + + + L +GA + ++ P Sbjct: 99 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 145 Score = 31.6 bits (70), Expect = 0.92 Identities = 20/61 (32%), Positives = 25/61 (40%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 D LG T L +A G V L GA + + G+T LH A + G LL Sbjct: 701 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 760 Query: 116 Q 116 Q Sbjct: 761 Q 761 Score = 29.6 bits (65), Expect = 3.5 Identities = 18/45 (40%), Positives = 22/45 (48%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVG 106 G T LH AA G T + L GA G+TAL +A R+G Sbjct: 740 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 784 >gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] Length = 1872 Score = 73.2 bits (178), Expect = 3e-13 Identities = 66/217 (30%), Positives = 93/217 (42%), Gaps = 27/217 (12%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 D+ N G+TALH+AA G+ V L GA + R T LH+A R+G + LL Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517 Query: 116 QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEA----- 170 Q ++A PD +TP+ + E + + LEA Sbjct: 518 Q------------HMAH-PDAATTNGYTPLHI-------SAREGQVDVASVLLEAGAAHS 557 Query: 171 -ENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLL 229 +G TPLHVA + +++ +LL A D G +PLH+A V LLL Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLL 616 Query: 230 RAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 GA+P A G TPL A + +A L +GA Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653 Score = 68.2 bits (165), Expect = 9e-12 Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 17/208 (8%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH++A G+ L AGA +A ++G T LH+A + G+ A+ LLQ R Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA-- 587 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES-EEDWKLQLEAENYEGHTPLH 180 D TP+ + D +K E+ A+N G+TPLH Sbjct: 588 -----------AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--GYTPLH 634 Query: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240 +A +++ L + GA+ + G +PLHLA + D++ LLL GAN Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQ-GVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 693 Query: 241 GGRTPLGSAMLRPNPILARLLRAHGAPE 268 G T L A +A +L HGA + Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQ 721 Score = 65.5 bits (158), Expect = 6e-11 Identities = 60/243 (24%), Positives = 98/243 (40%), Gaps = 38/243 (15%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 +D G TALH+A++ G+ V+ L GA + + G T L++A + + L Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149 Query: 115 LQPRPRRPREAPDTY------LAQGPD------------------------RTPDTNHTP 144 L+ + D + L QG + R DT Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 209 Query: 145 VALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKP 204 + L D + + + K+ + G TPLH+A + +V + LL + GA +D Sbjct: 210 LLLQNDHNADVQS-------KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262 Query: 205 EPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAH 264 G +PLH+A + ++++LLL G A+ G TPL A + + LL Sbjct: 263 ARN-GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321 Query: 265 GAP 267 GAP Sbjct: 322 GAP 324 Score = 60.5 bits (145), Expect = 2e-09 Identities = 64/239 (26%), Positives = 95/239 (39%), Gaps = 30/239 (12%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 ++ Q+ G T L++AA V+ L GA A G T L +A + G + L Sbjct: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182 Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEE-----ESEEDWKLQLE 169 L+ + P ++A D DT + L D + + + + +E + Sbjct: 183 LENDTKGKVRLPALHIAARKD---DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239 Query: 170 AENY---------------------EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 208 A +Y G TPLHVA + MV+LL D G +D + Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA-KTRD 298 Query: 209 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267 G +PLH A + V+ELLL GA AR G +PL A + + L H AP Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357 Score = 55.5 bits (132), Expect = 6e-08 Identities = 63/234 (26%), Positives = 88/234 (37%), Gaps = 32/234 (13%) Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPR 118 N G ALHLAA G V++L G+ + A ++G+TALH+A G + L++ Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120 Query: 119 PRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES--EEDWKLQLEAENYEGH 176 ++ + + NH V Y LE +S ED L +GH Sbjct: 121 ANINAQSQNGFTPL--YMAAQENHIDVVKYL---LENGANQSTATEDGFTPLAVALQQGH 175 Query: 177 T------------------PLHVAVIHKDVEMVRLL--RDAGADLDKP-----EPTCGRS 211 LH+A D + LL D AD+ G + Sbjct: 176 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 235 Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265 PLH+A +V LLL GA G TPL A R N + +LL G Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289 Score = 53.1 bits (126), Expect = 3e-07 Identities = 63/240 (26%), Positives = 86/240 (35%), Gaps = 48/240 (20%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T +H+AA +G + V L GA V RG TALH+A R G R L Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL------- 483 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181 L G ++A E TPLH+ Sbjct: 484 --------LRNGA--------------------------------LVDARAREEQTPLHI 503 Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241 A E+V+LL A D T G +PLH++ DV +LL AGA + Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAAT-TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK 562 Query: 242 GRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGSP 301 G TPL A + +A+LL A P ++ D+ + E+ SP Sbjct: 563 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622 Score = 51.2 bits (121), Expect = 1e-06 Identities = 53/192 (27%), Positives = 77/192 (40%), Gaps = 23/192 (11%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH+AA + L GA + ++G T LHLA + G LL Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688 Query: 122 PREAPD----TYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT 177 +LA D+ N + L K + + KL G+T Sbjct: 689 HMSTKSGLTSLHLAAQEDKV---NVADI-------LTKHGADQDAHTKL--------GYT 730 Query: 178 PLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAA 237 PL VA + +V+MV L GA+++ G +PLH A + ++ +LL+ GA P A Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKPNA 789 Query: 238 RMYGGRTPLGSA 249 G T L A Sbjct: 790 TTANGNTALAIA 801 Score = 49.7 bits (117), Expect = 3e-06 Identities = 65/245 (26%), Positives = 88/245 (35%), Gaps = 48/245 (19%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGL---------------------CVAER 93 +D + G T LH AA G VE L GA L CV Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351 Query: 94 RGH------------TALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTN 141 H TALH+A G + + LL R P+ Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR-------------ANPNARALNG 398 Query: 142 HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADL 201 TP+ + + K E + + ++A G TP+HVA + +V LL GA Sbjct: 399 FTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457 Query: 202 DKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLL 261 D G + LH+A A +V+ LLR GA AR +TPL A + +LL Sbjct: 458 DVTN-IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516 Query: 262 RAHGA 266 H A Sbjct: 517 LQHMA 521 Score = 43.1 bits (100), Expect = 3e-04 Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 1/107 (0%) Query: 172 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231 N G LH+A V +V+ L G+ +D G + LH+A A A+V+++L++ Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-GNTALHIASLAGQAEVVKVLVKE 119 Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 278 GAN A+ G TPL A + + + L +GA + ++ P Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166 Score = 31.6 bits (70), Expect = 0.92 Identities = 20/61 (32%), Positives = 25/61 (40%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 D LG T L +A G V L GA + + G+T LH A + G LL Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 781 Query: 116 Q 116 Q Sbjct: 782 Q 782 Score = 29.6 bits (65), Expect = 3.5 Identities = 18/45 (40%), Positives = 22/45 (48%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVG 106 G T LH AA G T + L GA G+TAL +A R+G Sbjct: 761 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 805 >gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] Length = 3957 Score = 73.2 bits (178), Expect = 3e-13 Identities = 66/217 (30%), Positives = 93/217 (42%), Gaps = 27/217 (12%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 D+ N G+TALH+AA G+ V L GA + R T LH+A R+G + LL Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517 Query: 116 QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEA----- 170 Q ++A PD +TP+ + E + + LEA Sbjct: 518 Q------------HMAH-PDAATTNGYTPLHI-------SAREGQVDVASVLLEAGAAHS 557 Query: 171 -ENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLL 229 +G TPLHVA + +++ +LL A D G +PLH+A V LLL Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLL 616 Query: 230 RAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 GA+P A G TPL A + +A L +GA Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653 Score = 68.2 bits (165), Expect = 9e-12 Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 17/208 (8%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH++A G+ L AGA +A ++G T LH+A + G+ A+ LLQ R Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA-- 587 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES-EEDWKLQLEAENYEGHTPLH 180 D TP+ + D +K E+ A+N G+TPLH Sbjct: 588 -----------AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--GYTPLH 634 Query: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240 +A +++ L + GA+ + G +PLHLA + D++ LLL GAN Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQ-GVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 693 Query: 241 GGRTPLGSAMLRPNPILARLLRAHGAPE 268 G T L A +A +L HGA + Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQ 721 Score = 65.5 bits (158), Expect = 6e-11 Identities = 60/243 (24%), Positives = 98/243 (40%), Gaps = 38/243 (15%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 +D G TALH+A++ G+ V+ L GA + + G T L++A + + L Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149 Query: 115 LQPRPRRPREAPDTY------LAQGPD------------------------RTPDTNHTP 144 L+ + D + L QG + R DT Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 209 Query: 145 VALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKP 204 + L D + + + K+ + G TPLH+A + +V + LL + GA +D Sbjct: 210 LLLQNDHNADVQS-------KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262 Query: 205 EPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAH 264 G +PLH+A + ++++LLL G A+ G TPL A + + LL Sbjct: 263 ARN-GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321 Query: 265 GAP 267 GAP Sbjct: 322 GAP 324 Score = 60.5 bits (145), Expect = 2e-09 Identities = 64/239 (26%), Positives = 95/239 (39%), Gaps = 30/239 (12%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 ++ Q+ G T L++AA V+ L GA A G T L +A + G + L Sbjct: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182 Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEE-----ESEEDWKLQLE 169 L+ + P ++A D DT + L D + + + + +E + Sbjct: 183 LENDTKGKVRLPALHIAARKD---DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239 Query: 170 AENY---------------------EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 208 A +Y G TPLHVA + MV+LL D G +D + Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA-KTRD 298 Query: 209 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267 G +PLH A + V+ELLL GA AR G +PL A + + L H AP Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357 Score = 55.5 bits (132), Expect = 6e-08 Identities = 63/234 (26%), Positives = 88/234 (37%), Gaps = 32/234 (13%) Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPR 118 N G ALHLAA G V++L G+ + A ++G+TALH+A G + L++ Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120 Query: 119 PRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES--EEDWKLQLEAENYEGH 176 ++ + + NH V Y LE +S ED L +GH Sbjct: 121 ANINAQSQNGFTPL--YMAAQENHIDVVKYL---LENGANQSTATEDGFTPLAVALQQGH 175 Query: 177 T------------------PLHVAVIHKDVEMVRLL--RDAGADLDKP-----EPTCGRS 211 LH+A D + LL D AD+ G + Sbjct: 176 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 235 Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265 PLH+A +V LLL GA G TPL A R N + +LL G Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289 Score = 53.1 bits (126), Expect = 3e-07 Identities = 63/240 (26%), Positives = 86/240 (35%), Gaps = 48/240 (20%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T +H+AA +G + V L GA V RG TALH+A R G R L Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL------- 483 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181 L G ++A E TPLH+ Sbjct: 484 --------LRNGA--------------------------------LVDARAREEQTPLHI 503 Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241 A E+V+LL A D T G +PLH++ DV +LL AGA + Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAAT-TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK 562 Query: 242 GRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGSP 301 G TPL A + +A+LL A P ++ D+ + E+ SP Sbjct: 563 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622 Score = 51.2 bits (121), Expect = 1e-06 Identities = 53/192 (27%), Positives = 77/192 (40%), Gaps = 23/192 (11%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH+AA + L GA + ++G T LHLA + G LL Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688 Query: 122 PREAPD----TYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT 177 +LA D+ N + L K + + KL G+T Sbjct: 689 HMSTKSGLTSLHLAAQEDKV---NVADI-------LTKHGADQDAHTKL--------GYT 730 Query: 178 PLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAA 237 PL VA + +V+MV L GA+++ G +PLH A + ++ +LL+ GA P A Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKPNA 789 Query: 238 RMYGGRTPLGSA 249 G T L A Sbjct: 790 TTANGNTALAIA 801 Score = 49.7 bits (117), Expect = 3e-06 Identities = 65/245 (26%), Positives = 88/245 (35%), Gaps = 48/245 (19%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGL---------------------CVAER 93 +D + G T LH AA G VE L GA L CV Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351 Query: 94 RGH------------TALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTN 141 H TALH+A G + + LL R P+ Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR-------------ANPNARALNG 398 Query: 142 HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADL 201 TP+ + + K E + + ++A G TP+HVA + +V LL GA Sbjct: 399 FTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457 Query: 202 DKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLL 261 D G + LH+A A +V+ LLR GA AR +TPL A + +LL Sbjct: 458 DVTN-IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516 Query: 262 RAHGA 266 H A Sbjct: 517 LQHMA 521 Score = 43.1 bits (100), Expect = 3e-04 Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 1/107 (0%) Query: 172 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231 N G LH+A V +V+ L G+ +D G + LH+A A A+V+++L++ Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-GNTALHIASLAGQAEVVKVLVKE 119 Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 278 GAN A+ G TPL A + + + L +GA + ++ P Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166 Score = 31.6 bits (70), Expect = 0.92 Identities = 20/61 (32%), Positives = 25/61 (40%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 D LG T L +A G V L GA + + G+T LH A + G LL Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 781 Query: 116 Q 116 Q Sbjct: 782 Q 782 Score = 29.6 bits (65), Expect = 3.5 Identities = 18/45 (40%), Positives = 22/45 (48%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVG 106 G T LH AA G T + L GA G+TAL +A R+G Sbjct: 761 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 805 >gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] Length = 1897 Score = 72.0 bits (175), Expect = 6e-13 Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 32/236 (13%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 +D + G T LH+A+ +G V+ L GA V+ + T LH+A R G A+ L Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489 Query: 115 LQPRPRRPREAPDTYLA--------------------QGPDRTPDTNHTPVAL-----YP 149 LQ + + +A D P+ HTP+ + + Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549 Query: 150 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 209 ++ L E+E+ + +G TPLHVA + V + LL + A + G Sbjct: 550 ETVLALLEKEASQ------ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN-G 602 Query: 210 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265 +PLH+AV D+++LLL G +P + + G TPL A + +AR L +G Sbjct: 603 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 658 Score = 61.6 bits (148), Expect = 8e-10 Identities = 59/193 (30%), Positives = 82/193 (42%), Gaps = 25/193 (12%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH+AA + L G +G T LHLA + G HA ALL + Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQAN 693 Query: 122 PREAPDTYLAQGPDRTP-----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176 L TP H PVA L K + ++A G+ Sbjct: 694 GN------LGNKSGLTPLHLVAQEGHVPVA----DVLIKHG--------VMVDATTRMGY 735 Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236 TPLHVA + ++++V+ L AD++ + G SPLH A + D++ LLL+ GA+P Sbjct: 736 TPLHVASHYGNIKLVKFLLQHQADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794 Query: 237 ARMYGGRTPLGSA 249 G TPL A Sbjct: 795 EVSSDGTTPLAIA 807 Score = 61.2 bits (147), Expect = 1e-09 Identities = 66/234 (28%), Positives = 92/234 (39%), Gaps = 28/234 (11%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 +L G T LH+AA G TV L A ++G T LH+A + G A LL Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 589 Query: 116 QPRPRRPREAPDTYLAQ--------------------GPDRTPDTN-HTPVALYPDSDLE 154 + R P A L G +P N +TP+ + + + Sbjct: 590 E-RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-Q 647 Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSP 212 E S + AE+ +G TPLH+A EMV LL + A +L G +P Sbjct: 648 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTP 704 Query: 213 LHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 LHL + V ++L++ G A G TPL A N L + L H A Sbjct: 705 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 758 Score = 60.5 bits (145), Expect = 2e-09 Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 16/221 (7%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G TALH+AA+ G+ V +L GA + ++G T L++A + + LL+ + Sbjct: 111 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 170 Query: 122 PREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAE 171 D + L QG + + P + +++ L Sbjct: 171 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 230 Query: 172 NYE-----GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 226 N + G TPLH+A ++++ + +LL + GA ++ P G +PLH+A ++ Sbjct: 231 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVR 289 Query: 227 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267 LLL GA + TPL A + ++ +L HGAP Sbjct: 290 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 330 Score = 58.5 bits (140), Expect = 7e-09 Identities = 65/225 (28%), Positives = 87/225 (38%), Gaps = 24/225 (10%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH+A +E L GA + G T LH+A +G + LLQ R Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGAS 462 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW---------------KL 166 P + + HT VA Y + K ++++D KL Sbjct: 463 P-NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 521 Query: 167 QLE------AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ 220 LE GHTPLH+A VE V L + A G +PLH+A + Sbjct: 522 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYG 580 Query: 221 AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265 V ELLL A+P A G TPL A+ N + +LL G Sbjct: 581 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625 Score = 55.8 bits (133), Expect = 5e-08 Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 29/238 (12%) Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115 N G LHLA+ G V +L L ++G+TALH+A G R L+ Sbjct: 75 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134 Query: 116 -QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-----KLQLE 169 + + Y+A NH V + + + +E+ + LQ Sbjct: 135 ANVNAQSQKGFTPLYMA------AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 188 Query: 170 AENYEGH------------TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAV 217 EN H LH+A + D +L + D T G +PLH+A Sbjct: 189 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAA 247 Query: 218 EAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDE 274 + +V +LLL GA+ G TPL A R N I+ RLL GA E + +DE Sbjct: 248 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 305 Score = 55.5 bits (132), Expect = 6e-08 Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 25/234 (10%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 D+ + G T LH+AA + + L GA + + G T LH+A R G R LL Sbjct: 233 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 292 Query: 116 ----QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED--- 163 Q + E + A G R + + P+ + L ++ D Sbjct: 293 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 352 Query: 164 ---WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLH 214 LQ +AE + TPLHVA + ++L D GA KP G +PLH Sbjct: 353 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLH 409 Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 267 +A + V+ELLL+ GA+ A G TPL A + PI+ LL+ +P Sbjct: 410 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463 Score = 38.1 bits (87), Expect = 0.010 Identities = 56/235 (23%), Positives = 85/235 (36%), Gaps = 46/235 (19%) Query: 64 TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPR 123 T LH AA G E L GA + + G + +H+A + C R LLQ Sbjct: 307 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ------- 359 Query: 124 EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAV 183 Y A+ D T D + TP+ + + + D + + G TPLH+A Sbjct: 360 -----YDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIAC 412 Query: 184 IHKDVEMVRLLRDAGADLDK----------------------------PEPTCGR----S 211 V ++ LL GA +D P + Sbjct: 413 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 472 Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 PLH+A A +V + LL+ A A+ +TPL A + + +LL + A Sbjct: 473 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 527 >gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] Length = 1881 Score = 72.0 bits (175), Expect = 6e-13 Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 32/236 (13%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 +D + G T LH+A+ +G V+ L GA V+ + T LH+A R G A+ L Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456 Query: 115 LQPRPRRPREAPDTYLA--------------------QGPDRTPDTNHTPVAL-----YP 149 LQ + + +A D P+ HTP+ + + Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516 Query: 150 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 209 ++ L E+E+ + +G TPLHVA + V + LL + A + G Sbjct: 517 ETVLALLEKEASQ------ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN-G 569 Query: 210 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265 +PLH+AV D+++LLL G +P + + G TPL A + +AR L +G Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625 Score = 61.6 bits (148), Expect = 8e-10 Identities = 59/193 (30%), Positives = 82/193 (42%), Gaps = 25/193 (12%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH+AA + L G +G T LHLA + G HA ALL + Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQAN 660 Query: 122 PREAPDTYLAQGPDRTP-----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176 L TP H PVA L K + ++A G+ Sbjct: 661 GN------LGNKSGLTPLHLVAQEGHVPVA----DVLIKHG--------VMVDATTRMGY 702 Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236 TPLHVA + ++++V+ L AD++ + G SPLH A + D++ LLL+ GA+P Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761 Query: 237 ARMYGGRTPLGSA 249 G TPL A Sbjct: 762 EVSSDGTTPLAIA 774 Score = 61.2 bits (147), Expect = 1e-09 Identities = 66/234 (28%), Positives = 92/234 (39%), Gaps = 28/234 (11%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 +L G T LH+AA G TV L A ++G T LH+A + G A LL Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556 Query: 116 QPRPRRPREAPDTYLAQ--------------------GPDRTPDTN-HTPVALYPDSDLE 154 + R P A L G +P N +TP+ + + + Sbjct: 557 E-RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-Q 614 Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSP 212 E S + AE+ +G TPLH+A EMV LL + A +L G +P Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTP 671 Query: 213 LHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 LHL + V ++L++ G A G TPL A N L + L H A Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725 Score = 60.5 bits (145), Expect = 2e-09 Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 16/221 (7%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G TALH+AA+ G+ V +L GA + ++G T L++A + + LL+ + Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137 Query: 122 PREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAE 171 D + L QG + + P + +++ L Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197 Query: 172 NYE-----GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 226 N + G TPLH+A ++++ + +LL + GA ++ P G +PLH+A ++ Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVR 256 Query: 227 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267 LLL GA + TPL A + ++ +L HGAP Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297 Score = 58.5 bits (140), Expect = 7e-09 Identities = 65/225 (28%), Positives = 87/225 (38%), Gaps = 24/225 (10%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH+A +E L GA + G T LH+A +G + LLQ R Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGAS 429 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW---------------KL 166 P + + HT VA Y + K ++++D KL Sbjct: 430 P-NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488 Query: 167 QLE------AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ 220 LE GHTPLH+A VE V L + A G +PLH+A + Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYG 547 Query: 221 AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265 V ELLL A+P A G TPL A+ N + +LL G Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592 Score = 55.8 bits (133), Expect = 5e-08 Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 29/238 (12%) Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115 N G LHLA+ G V +L L ++G+TALH+A G R L+ Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101 Query: 116 -QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-----KLQLE 169 + + Y+A NH V + + + +E+ + LQ Sbjct: 102 ANVNAQSQKGFTPLYMA------AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155 Query: 170 AENYEGH------------TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAV 217 EN H LH+A + D +L + D T G +PLH+A Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAA 214 Query: 218 EAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDE 274 + +V +LLL GA+ G TPL A R N I+ RLL GA E + +DE Sbjct: 215 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272 Score = 55.5 bits (132), Expect = 6e-08 Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 25/234 (10%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 D+ + G T LH+AA + + L GA + + G T LH+A R G R LL Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259 Query: 116 ----QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED--- 163 Q + E + A G R + + P+ + L ++ D Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319 Query: 164 ---WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLH 214 LQ +AE + TPLHVA + ++L D GA KP G +PLH Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLH 376 Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 267 +A + V+ELLL+ GA+ A G TPL A + PI+ LL+ +P Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430 Score = 38.1 bits (87), Expect = 0.010 Identities = 56/235 (23%), Positives = 85/235 (36%), Gaps = 46/235 (19%) Query: 64 TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPR 123 T LH AA G E L GA + + G + +H+A + C R LLQ Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ------- 326 Query: 124 EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAV 183 Y A+ D T D + TP+ + + + D + + G TPLH+A Sbjct: 327 -----YDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIAC 379 Query: 184 IHKDVEMVRLLRDAGADLDK----------------------------PEPTCGR----S 211 V ++ LL GA +D P + Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439 Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 PLH+A A +V + LL+ A A+ +TPL A + + +LL + A Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494 >gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] Length = 1880 Score = 72.0 bits (175), Expect = 6e-13 Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 32/236 (13%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 +D + G T LH+A+ +G V+ L GA V+ + T LH+A R G A+ L Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456 Query: 115 LQPRPRRPREAPDTYLA--------------------QGPDRTPDTNHTPVAL-----YP 149 LQ + + +A D P+ HTP+ + + Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516 Query: 150 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 209 ++ L E+E+ + +G TPLHVA + V + LL + A + G Sbjct: 517 ETVLALLEKEASQ------ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN-G 569 Query: 210 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265 +PLH+AV D+++LLL G +P + + G TPL A + +AR L +G Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625 Score = 61.6 bits (148), Expect = 8e-10 Identities = 59/193 (30%), Positives = 82/193 (42%), Gaps = 25/193 (12%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH+AA + L G +G T LHLA + G HA ALL + Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQAN 660 Query: 122 PREAPDTYLAQGPDRTP-----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176 L TP H PVA L K + ++A G+ Sbjct: 661 GN------LGNKSGLTPLHLVAQEGHVPVA----DVLIKHG--------VMVDATTRMGY 702 Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236 TPLHVA + ++++V+ L AD++ + G SPLH A + D++ LLL+ GA+P Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761 Query: 237 ARMYGGRTPLGSA 249 G TPL A Sbjct: 762 EVSSDGTTPLAIA 774 Score = 61.2 bits (147), Expect = 1e-09 Identities = 66/234 (28%), Positives = 92/234 (39%), Gaps = 28/234 (11%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 +L G T LH+AA G TV L A ++G T LH+A + G A LL Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556 Query: 116 QPRPRRPREAPDTYLAQ--------------------GPDRTPDTN-HTPVALYPDSDLE 154 + R P A L G +P N +TP+ + + + Sbjct: 557 E-RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-Q 614 Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSP 212 E S + AE+ +G TPLH+A EMV LL + A +L G +P Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTP 671 Query: 213 LHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 LHL + V ++L++ G A G TPL A N L + L H A Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725 Score = 60.5 bits (145), Expect = 2e-09 Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 16/221 (7%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G TALH+AA+ G+ V +L GA + ++G T L++A + + LL+ + Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137 Query: 122 PREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAE 171 D + L QG + + P + +++ L Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197 Query: 172 NYE-----GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 226 N + G TPLH+A ++++ + +LL + GA ++ P G +PLH+A ++ Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVR 256 Query: 227 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267 LLL GA + TPL A + ++ +L HGAP Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297 Score = 58.5 bits (140), Expect = 7e-09 Identities = 65/225 (28%), Positives = 87/225 (38%), Gaps = 24/225 (10%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH+A +E L GA + G T LH+A +G + LLQ R Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGAS 429 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW---------------KL 166 P + + HT VA Y + K ++++D KL Sbjct: 430 P-NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488 Query: 167 QLE------AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ 220 LE GHTPLH+A VE V L + A G +PLH+A + Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYG 547 Query: 221 AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265 V ELLL A+P A G TPL A+ N + +LL G Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592 Score = 55.8 bits (133), Expect = 5e-08 Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 29/238 (12%) Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115 N G LHLA+ G V +L L ++G+TALH+A G R L+ Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101 Query: 116 -QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-----KLQLE 169 + + Y+A NH V + + + +E+ + LQ Sbjct: 102 ANVNAQSQKGFTPLYMA------AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155 Query: 170 AENYEGH------------TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAV 217 EN H LH+A + D +L + D T G +PLH+A Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAA 214 Query: 218 EAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDE 274 + +V +LLL GA+ G TPL A R N I+ RLL GA E + +DE Sbjct: 215 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272 Score = 55.5 bits (132), Expect = 6e-08 Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 25/234 (10%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 D+ + G T LH+AA + + L GA + + G T LH+A R G R LL Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259 Query: 116 ----QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED--- 163 Q + E + A G R + + P+ + L ++ D Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319 Query: 164 ---WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLH 214 LQ +AE + TPLHVA + ++L D GA KP G +PLH Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLH 376 Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 267 +A + V+ELLL+ GA+ A G TPL A + PI+ LL+ +P Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430 Score = 38.1 bits (87), Expect = 0.010 Identities = 56/235 (23%), Positives = 85/235 (36%), Gaps = 46/235 (19%) Query: 64 TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPR 123 T LH AA G E L GA + + G + +H+A + C R LLQ Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ------- 326 Query: 124 EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAV 183 Y A+ D T D + TP+ + + + D + + G TPLH+A Sbjct: 327 -----YDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIAC 379 Query: 184 IHKDVEMVRLLRDAGADLDK----------------------------PEPTCGR----S 211 V ++ LL GA +D P + Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439 Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 PLH+A A +V + LL+ A A+ +TPL A + + +LL + A Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494 >gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] Length = 1719 Score = 72.0 bits (175), Expect = 6e-13 Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 32/236 (13%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 +D + G T LH+A+ +G V+ L GA V+ + T LH+A R G A+ L Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456 Query: 115 LQPRPRRPREAPDTYLA--------------------QGPDRTPDTNHTPVAL-----YP 149 LQ + + +A D P+ HTP+ + + Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516 Query: 150 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 209 ++ L E+E+ + +G TPLHVA + V + LL + A + G Sbjct: 517 ETVLALLEKEASQ------ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN-G 569 Query: 210 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265 +PLH+AV D+++LLL G +P + + G TPL A + +AR L +G Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625 Score = 61.6 bits (148), Expect = 8e-10 Identities = 59/193 (30%), Positives = 82/193 (42%), Gaps = 25/193 (12%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH+AA + L G +G T LHLA + G HA ALL + Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQAN 660 Query: 122 PREAPDTYLAQGPDRTP-----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176 L TP H PVA L K + ++A G+ Sbjct: 661 GN------LGNKSGLTPLHLVAQEGHVPVA----DVLIKHG--------VMVDATTRMGY 702 Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236 TPLHVA + ++++V+ L AD++ + G SPLH A + D++ LLL+ GA+P Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761 Query: 237 ARMYGGRTPLGSA 249 G TPL A Sbjct: 762 EVSSDGTTPLAIA 774 Score = 61.2 bits (147), Expect = 1e-09 Identities = 66/234 (28%), Positives = 92/234 (39%), Gaps = 28/234 (11%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 +L G T LH+AA G TV L A ++G T LH+A + G A LL Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556 Query: 116 QPRPRRPREAPDTYLAQ--------------------GPDRTPDTN-HTPVALYPDSDLE 154 + R P A L G +P N +TP+ + + + Sbjct: 557 E-RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-Q 614 Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSP 212 E S + AE+ +G TPLH+A EMV LL + A +L G +P Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTP 671 Query: 213 LHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 LHL + V ++L++ G A G TPL A N L + L H A Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725 Score = 60.5 bits (145), Expect = 2e-09 Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 16/221 (7%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G TALH+AA+ G+ V +L GA + ++G T L++A + + LL+ + Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137 Query: 122 PREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAE 171 D + L QG + + P + +++ L Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197 Query: 172 NYE-----GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 226 N + G TPLH+A ++++ + +LL + GA ++ P G +PLH+A ++ Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVR 256 Query: 227 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267 LLL GA + TPL A + ++ +L HGAP Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297 Score = 58.5 bits (140), Expect = 7e-09 Identities = 65/225 (28%), Positives = 87/225 (38%), Gaps = 24/225 (10%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH+A +E L GA + G T LH+A +G + LLQ R Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGAS 429 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW---------------KL 166 P + + HT VA Y + K ++++D KL Sbjct: 430 P-NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488 Query: 167 QLE------AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ 220 LE GHTPLH+A VE V L + A G +PLH+A + Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYG 547 Query: 221 AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265 V ELLL A+P A G TPL A+ N + +LL G Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592 Score = 55.8 bits (133), Expect = 5e-08 Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 29/238 (12%) Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115 N G LHLA+ G V +L L ++G+TALH+A G R L+ Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101 Query: 116 -QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-----KLQLE 169 + + Y+A NH V + + + +E+ + LQ Sbjct: 102 ANVNAQSQKGFTPLYMA------AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155 Query: 170 AENYEGH------------TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAV 217 EN H LH+A + D +L + D T G +PLH+A Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAA 214 Query: 218 EAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDE 274 + +V +LLL GA+ G TPL A R N I+ RLL GA E + +DE Sbjct: 215 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272 Score = 55.5 bits (132), Expect = 6e-08 Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 25/234 (10%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 D+ + G T LH+AA + + L GA + + G T LH+A R G R LL Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259 Query: 116 ----QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED--- 163 Q + E + A G R + + P+ + L ++ D Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319 Query: 164 ---WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLH 214 LQ +AE + TPLHVA + ++L D GA KP G +PLH Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLH 376 Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 267 +A + V+ELLL+ GA+ A G TPL A + PI+ LL+ +P Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430 Score = 38.1 bits (87), Expect = 0.010 Identities = 56/235 (23%), Positives = 85/235 (36%), Gaps = 46/235 (19%) Query: 64 TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPR 123 T LH AA G E L GA + + G + +H+A + C R LLQ Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ------- 326 Query: 124 EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAV 183 Y A+ D T D + TP+ + + + D + + G TPLH+A Sbjct: 327 -----YDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIAC 379 Query: 184 IHKDVEMVRLLRDAGADLDK----------------------------PEPTCGR----S 211 V ++ LL GA +D P + Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439 Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 PLH+A A +V + LL+ A A+ +TPL A + + +LL + A Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494 >gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] Length = 1856 Score = 72.0 bits (175), Expect = 6e-13 Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 32/236 (13%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 +D + G T LH+A+ +G V+ L GA V+ + T LH+A R G A+ L Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456 Query: 115 LQPRPRRPREAPDTYLA--------------------QGPDRTPDTNHTPVAL-----YP 149 LQ + + +A D P+ HTP+ + + Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516 Query: 150 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 209 ++ L E+E+ + +G TPLHVA + V + LL + A + G Sbjct: 517 ETVLALLEKEASQ------ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN-G 569 Query: 210 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265 +PLH+AV D+++LLL G +P + + G TPL A + +AR L +G Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625 Score = 61.6 bits (148), Expect = 8e-10 Identities = 59/193 (30%), Positives = 82/193 (42%), Gaps = 25/193 (12%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH+AA + L G +G T LHLA + G HA ALL + Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQAN 660 Query: 122 PREAPDTYLAQGPDRTP-----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176 L TP H PVA L K + ++A G+ Sbjct: 661 GN------LGNKSGLTPLHLVAQEGHVPVA----DVLIKHG--------VMVDATTRMGY 702 Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236 TPLHVA + ++++V+ L AD++ + G SPLH A + D++ LLL+ GA+P Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761 Query: 237 ARMYGGRTPLGSA 249 G TPL A Sbjct: 762 EVSSDGTTPLAIA 774 Score = 61.2 bits (147), Expect = 1e-09 Identities = 66/234 (28%), Positives = 92/234 (39%), Gaps = 28/234 (11%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 +L G T LH+AA G TV L A ++G T LH+A + G A LL Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556 Query: 116 QPRPRRPREAPDTYLAQ--------------------GPDRTPDTN-HTPVALYPDSDLE 154 + R P A L G +P N +TP+ + + + Sbjct: 557 E-RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-Q 614 Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSP 212 E S + AE+ +G TPLH+A EMV LL + A +L G +P Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTP 671 Query: 213 LHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 LHL + V ++L++ G A G TPL A N L + L H A Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725 Score = 60.5 bits (145), Expect = 2e-09 Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 16/221 (7%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G TALH+AA+ G+ V +L GA + ++G T L++A + + LL+ + Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137 Query: 122 PREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAE 171 D + L QG + + P + +++ L Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197 Query: 172 NYE-----GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 226 N + G TPLH+A ++++ + +LL + GA ++ P G +PLH+A ++ Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVR 256 Query: 227 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267 LLL GA + TPL A + ++ +L HGAP Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297 Score = 58.5 bits (140), Expect = 7e-09 Identities = 65/225 (28%), Positives = 87/225 (38%), Gaps = 24/225 (10%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G T LH+A +E L GA + G T LH+A +G + LLQ R Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGAS 429 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW---------------KL 166 P + + HT VA Y + K ++++D KL Sbjct: 430 P-NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488 Query: 167 QLE------AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ 220 LE GHTPLH+A VE V L + A G +PLH+A + Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYG 547 Query: 221 AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265 V ELLL A+P A G TPL A+ N + +LL G Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592 Score = 55.8 bits (133), Expect = 5e-08 Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 29/238 (12%) Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115 N G LHLA+ G V +L L ++G+TALH+A G R L+ Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101 Query: 116 -QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-----KLQLE 169 + + Y+A NH V + + + +E+ + LQ Sbjct: 102 ANVNAQSQKGFTPLYMA------AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155 Query: 170 AENYEGH------------TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAV 217 EN H LH+A + D +L + D T G +PLH+A Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAA 214 Query: 218 EAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDE 274 + +V +LLL GA+ G TPL A R N I+ RLL GA E + +DE Sbjct: 215 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272 Score = 55.5 bits (132), Expect = 6e-08 Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 25/234 (10%) Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 D+ + G T LH+AA + + L GA + + G T LH+A R G R LL Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259 Query: 116 ----QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED--- 163 Q + E + A G R + + P+ + L ++ D Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319 Query: 164 ---WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLH 214 LQ +AE + TPLHVA + ++L D GA KP G +PLH Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLH 376 Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 267 +A + V+ELLL+ GA+ A G TPL A + PI+ LL+ +P Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430 Score = 38.1 bits (87), Expect = 0.010 Identities = 56/235 (23%), Positives = 85/235 (36%), Gaps = 46/235 (19%) Query: 64 TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPR 123 T LH AA G E L GA + + G + +H+A + C R LLQ Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ------- 326 Query: 124 EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAV 183 Y A+ D T D + TP+ + + + D + + G TPLH+A Sbjct: 327 -----YDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIAC 379 Query: 184 IHKDVEMVRLLRDAGADLDK----------------------------PEPTCGR----S 211 V ++ LL GA +D P + Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439 Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 PLH+A A +V + LL+ A A+ +TPL A + + +LL + A Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494 >gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2 [Homo sapiens] Length = 474 Score = 70.9 bits (172), Expect = 1e-12 Identities = 75/229 (32%), Positives = 97/229 (42%), Gaps = 42/229 (18%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G+TALH A G T+ V L AGA +A++ G LHL G CA LL+ Sbjct: 193 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR----- 247 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQL----EAENYEGHT 177 + A+ R+ + TP L+ + L E D L+ +A N EG T Sbjct: 248 -------FGARVDGRSEEEEETP--LHVAARLGHVE---LADLLLRRGACPDARNAEGWT 295 Query: 178 PLHV-------------AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADV 224 PL A + +++ LL AGAD D + R PLHLA A V Sbjct: 296 PLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR-PLHLACRRGHAAV 354 Query: 225 LELLLRAGANPAARMYGGRTPLGSAMLRPNPILA-------RLLRAHGA 266 +ELLL G + YGG TPL A+ P LA R L HGA Sbjct: 355 VELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403 Score = 43.9 bits (102), Expect = 2e-04 Identities = 46/138 (33%), Positives = 60/138 (43%), Gaps = 14/138 (10%) Query: 147 LYPDSDLEKEEEESEEDWK-----LQLEAENYEGH--TPLHVAVIHKDVEMVRLLRDAGA 199 L PDS + + E D++ L+L + YE TPLHVA E++RLL A Sbjct: 126 LAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRA 185 Query: 200 DLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL----GSAMLRPNP 255 D GR+ LH A A + +LL AGA+P G+ PL G L Sbjct: 186 RPDSAPG--GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAE 243 Query: 256 ILARL-LRAHGAPEPEGE 272 +L R R G E E E Sbjct: 244 LLLRFGARVDGRSEEEEE 261 >gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1 [Homo sapiens] Length = 512 Score = 70.9 bits (172), Expect = 1e-12 Identities = 75/229 (32%), Positives = 97/229 (42%), Gaps = 42/229 (18%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G+TALH A G T+ V L AGA +A++ G LHL G CA LL+ Sbjct: 193 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR----- 247 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQL----EAENYEGHT 177 + A+ R+ + TP L+ + L E D L+ +A N EG T Sbjct: 248 -------FGARVDGRSEEEEETP--LHVAARLGHVE---LADLLLRRGACPDARNAEGWT 295 Query: 178 PLHV-------------AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADV 224 PL A + +++ LL AGAD D + R PLHLA A V Sbjct: 296 PLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR-PLHLACRRGHAAV 354 Query: 225 LELLLRAGANPAARMYGGRTPLGSAMLRPNPILA-------RLLRAHGA 266 +ELLL G + YGG TPL A+ P LA R L HGA Sbjct: 355 VELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403 Score = 43.9 bits (102), Expect = 2e-04 Identities = 46/138 (33%), Positives = 60/138 (43%), Gaps = 14/138 (10%) Query: 147 LYPDSDLEKEEEESEEDWK-----LQLEAENYEGH--TPLHVAVIHKDVEMVRLLRDAGA 199 L PDS + + E D++ L+L + YE TPLHVA E++RLL A Sbjct: 126 LAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRA 185 Query: 200 DLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL----GSAMLRPNP 255 D GR+ LH A A + +LL AGA+P G+ PL G L Sbjct: 186 RPDSAPG--GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAE 243 Query: 256 ILARL-LRAHGAPEPEGE 272 +L R R G E E E Sbjct: 244 LLLRFGARVDGRSEEEEE 261 >gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3 [Homo sapiens] Length = 452 Score = 70.9 bits (172), Expect = 1e-12 Identities = 75/229 (32%), Positives = 97/229 (42%), Gaps = 42/229 (18%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G+TALH A G T+ V L AGA +A++ G LHL G CA LL+ Sbjct: 133 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR----- 187 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQL----EAENYEGHT 177 + A+ R+ + TP L+ + L E D L+ +A N EG T Sbjct: 188 -------FGARVDGRSEEEEETP--LHVAARLGHVE---LADLLLRRGACPDARNAEGWT 235 Query: 178 PLHV-------------AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADV 224 PL A + +++ LL AGAD D + R PLHLA A V Sbjct: 236 PLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR-PLHLACRRGHAAV 294 Query: 225 LELLLRAGANPAARMYGGRTPLGSAMLRPNPILA-------RLLRAHGA 266 +ELLL G + YGG TPL A+ P LA R L HGA Sbjct: 295 VELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 343 Score = 45.8 bits (107), Expect = 5e-05 Identities = 61/194 (31%), Positives = 73/194 (37%), Gaps = 19/194 (9%) Query: 96 HTALHLACRVGAHACA--RALLQPRPRRPREAP---DTYLAQGPDRTPDTNHTPVALYPD 150 H HL C A AC R +P PR +P Q T D P Sbjct: 10 HWGHHLGCLPSAPACRIWRPHSRPAWEPPRPSPLLCQDMALQNALYTGDLARLQELFPPH 69 Query: 151 S--DLEKEEEESEEDWKLQ---LEAENYEGH--TPLHVAVIHKDVEMVRLLRDAGADLDK 203 S DL E +E W L + YE TPLHVA E++RLL A D Sbjct: 70 STADLLLESRAAEPRWSSHQRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDS 129 Query: 204 PEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL----GSAMLRPNPILAR 259 GR+ LH A A + +LL AGA+P G+ PL G L +L R Sbjct: 130 APG--GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR 187 Query: 260 L-LRAHGAPEPEGE 272 R G E E E Sbjct: 188 FGARVDGRSEEEEE 201 >gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo sapiens] Length = 765 Score = 70.5 bits (171), Expect = 2e-12 Identities = 62/205 (30%), Positives = 81/205 (39%), Gaps = 48/205 (23%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G LH AA G+ T L GA + ER G T LHLA + AR L+ Sbjct: 428 GWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV------ 481 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181 R D N EG TPLHV Sbjct: 482 -------------SRQADPN----------------------------LHEAEGKTPLHV 500 Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241 A V +V+LL GA+LD + R+PLHLAVE ++ LL++GA P A Sbjct: 501 AAYFGHVSLVKLLTSQGAELDAQQRNL-RTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559 Query: 242 GRTPLGSAMLRPNPILARLLRAHGA 266 G PL +A R ++ ++L +GA Sbjct: 560 GYGPLHTAAARGKYLICKMLLRYGA 584 Score = 61.2 bits (147), Expect = 1e-09 Identities = 57/192 (29%), Positives = 85/192 (44%), Gaps = 17/192 (8%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G+T LH+AA G S V+ L + GA L +R T LHLA G + LL+ Sbjct: 494 GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS---- 549 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEE-ESEEDWKLQLEAENYEGHTPLH 180 PD + + P L+ + K + + LE ++G TPLH Sbjct: 550 ---------GAVPDALDQSGYGP--LHTAAARGKYLICKMLLRYGASLELPTHQGWTPLH 598 Query: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240 +A +E++ LL ++ A++ +PLHLA V+ LL+ GA+P A Sbjct: 599 LAAYKGHLEIIHLLAESHANMGALGAV-NWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657 Query: 241 GGRTPLGSAMLR 252 G TPL A+ R Sbjct: 658 SGWTPLHLAVQR 669 Score = 56.2 bits (134), Expect = 3e-08 Identities = 51/191 (26%), Positives = 76/191 (39%), Gaps = 17/191 (8%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 ++L G T LHLAA G + L + A + T LHLA R G A AL Sbjct: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645 Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 174 LQ P+ + TP+ L E + A N Sbjct: 646 LQ-------------CGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEH-HANVHARNKV 691 Query: 175 GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234 G TP H+A + + ++++L +AGA LD + +PL LA+ ++ ++ L G Sbjct: 692 GWTPAHLAALKGNTAILKVLVEAGAQLDVQDGV-SCTPLQLALRSRKQGIMSFL--EGKE 748 Query: 235 PAARMYGGRTP 245 P+ GG P Sbjct: 749 PSVATLGGSKP 759 Score = 55.5 bits (132), Expect = 6e-08 Identities = 67/219 (30%), Positives = 94/219 (42%), Gaps = 18/219 (8%) Query: 49 SAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAH 108 S G E +D Q +T LHLA G+ ++ L +GA ++ G+ LH A G + Sbjct: 515 SQGAE-LDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573 Query: 109 ACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKL-Q 167 + LL R L TP +A Y LE +E + Sbjct: 574 LICKMLL-------RYGASLELPTHQGWTP----LHLAAY-KGHLEIIHLLAESHANMGA 621 Query: 168 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL 227 L A N+ TPLH+A H + +V L GAD + E + G +PLHLAV+ + Sbjct: 622 LGAVNW---TPLHLAARHGEEAVVSALLQCGADPNAAEQS-GWTPLHLAVQRSTFLSVIN 677 Query: 228 LLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 LL AN AR G TP A L+ N + ++L GA Sbjct: 678 LLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA 716 Score = 50.4 bits (119), Expect = 2e-06 Identities = 35/93 (37%), Positives = 47/93 (50%), Gaps = 1/93 (1%) Query: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233 +G PLH A + D RLL D GA +D E G +PLHLA + +V LL+ A Sbjct: 427 DGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENVARLLVSRQA 485 Query: 234 NPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 +P G+TPL A + L +LL + GA Sbjct: 486 DPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGA 518 Score = 47.0 bits (110), Expect = 2e-05 Identities = 41/125 (32%), Positives = 54/125 (43%), Gaps = 1/125 (0%) Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236 TPLH V VE VRLL D+D + G +PL +A + Q D+ LLL GA+ Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDC-QTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422 Query: 237 ARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEE 296 G PL A + ARLL HGA E E P ++ ++ + Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482 Query: 297 RQGSP 301 RQ P Sbjct: 483 RQADP 487 Score = 44.7 bits (104), Expect = 1e-04 Identities = 33/102 (32%), Positives = 52/102 (50%), Gaps = 2/102 (1%) Query: 168 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL 227 ++A+ EG TPLH+A + + RLL AD + E G++PLH+A +++L Sbjct: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAE-GKTPLHVAAYFGHVSLVKL 512 Query: 228 LLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAPE 268 L GA A+ RTPL A+ R + LL++ P+ Sbjct: 513 LTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPD 554 Score = 40.0 bits (92), Expect = 0.003 Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 1/114 (0%) Query: 165 KLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADV 224 ++ ++ + G+TPL +A + ++ LL GAD ++ + G +PLH A + Sbjct: 385 EVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDED-GWAPLHFAAQNGDDGT 443 Query: 225 LELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 278 LLL GA A+ G TPL A +ARLL + A E E P Sbjct: 444 ARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTP 497 >gi|157743284 ankyrin repeat domain 52 [Homo sapiens] Length = 1076 Score = 70.5 bits (171), Expect = 2e-12 Identities = 76/263 (28%), Positives = 111/263 (42%), Gaps = 35/263 (13%) Query: 31 CRGLPSSS-----ATSLRMGTRFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAG 85 CR L SS +SL SAG + ++ ++LG+T LH AA G + L ++G Sbjct: 388 CRKLLSSGQLYSIVSSLSNEHVLSAGFD-INTPDNLGRTCLHAAASGGNVECLNLLLSSG 446 Query: 86 AGLCVAERRGHTALHLACRVGAHACARALLQP------------RPRRPREAPDTYLAQG 133 A L ++ G T LH A G++ CA L+ P A DTY Sbjct: 447 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE 506 Query: 134 PDRTPDTNHTPVALYPDSDLE-KEEEESEEDWKLQLEAEN--------YEGHTPLHVAVI 184 P HTP + + D KE E + L+ +N +G+T +H A Sbjct: 507 P-------HTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAA 559 Query: 185 HKDVEMVRLLRDAGAD-LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGR 243 + + + + LL + + L+ E T SPLHLA + L+ L N R + GR Sbjct: 560 YGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGR 619 Query: 244 TPLGSAMLRPNPILARLLRAHGA 266 T L A R + +L AHGA Sbjct: 620 TALFLATERGSTECVEVLTAHGA 642 Score = 57.4 bits (137), Expect = 2e-08 Identities = 70/248 (28%), Positives = 93/248 (37%), Gaps = 23/248 (9%) Query: 25 RSWARGCRGLPSSSATSLRMGTRFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 84 R W S SL + + D+ + GQT L LA + G V L Sbjct: 651 RKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710 Query: 85 GAGLCVAERRGHTALHLACRVGAHACARALLQPRP----RRPREAPDTYLAQGPDRTPDT 140 G+ A+ RG TALH G C ALL R + +LA T Sbjct: 711 GSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVL 770 Query: 141 NHTPVALYPDSDLEKEEEES-------------EEDWKLQLEAENY---EGH--TPLHVA 182 A L+ + S E+ +L LE + EG+ TPLH A Sbjct: 771 RTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCA 830 Query: 183 VI-HKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241 VI ++D LL GA + GR+PLH A A L +LL+ A A + Sbjct: 831 VINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT 890 Query: 242 GRTPLGSA 249 GRT L +A Sbjct: 891 GRTALMTA 898 Score = 55.5 bits (132), Expect = 6e-08 Identities = 51/190 (26%), Positives = 81/190 (42%), Gaps = 14/190 (7%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G LH AA G+ V+ L GA + G+TALH+AC +G A A L+ Sbjct: 206 GYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVN----- 260 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181 ++ D TP+ + S E + + ++ EG +PLH+ Sbjct: 261 --------AGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHM 312 Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241 A IH ++L G+++D + G +PLH+A ++ L+ GA+ A R Sbjct: 313 AAIHGRFTRSQILIQNGSEIDCAD-KFGNTPLHVAARYGHELLISTLMTNGADTARRGIH 371 Query: 242 GRTPLGSAML 251 PL A+L Sbjct: 372 DMFPLHLAVL 381 Score = 48.9 bits (115), Expect = 6e-06 Identities = 64/236 (27%), Positives = 106/236 (44%), Gaps = 29/236 (12%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 ++ ++ L QT LH+AA T E L + L VA+R G +ALH A G L Sbjct: 100 VNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLL 159 Query: 115 LQP---------RPRRPR---------EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKE 156 L + R+P E +A+G D L+ + + Sbjct: 160 LNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQI 219 Query: 157 EEESEEDWKLQLEAE----NYEGHTPLHVAV-IHKDVEMVRLLRDAGADLDKPEPTCGRS 211 E + L++ AE N G+T LH+A + +D + L+ +AGA++++P G + Sbjct: 220 EVVK---YLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV-NAGANVNQPNDK-GFT 274 Query: 212 PLHLA-VEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 PLH+A V A LELL+ GA+ + G++PL A + +++L +G+ Sbjct: 275 PLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGS 330 Score = 48.9 bits (115), Expect = 6e-06 Identities = 62/233 (26%), Positives = 96/233 (41%), Gaps = 30/233 (12%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 ++ Q+ G++ LH+AAI G + + L G+ + A++ G+T LH+A R G L Sbjct: 299 VNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358 Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 174 + DT D P H V L+ SD ++ S + + + N Sbjct: 359 MT-------NGADTARRGIHDMFP--LHLAV-LFGFSDCCRKLLSSGQLYSIVSSLSNE- 407 Query: 175 GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234 HV AG D++ P+ GR+ LH A + L LLL +GA+ Sbjct: 408 -----HVL-------------SAGFDINTPD-NLGRTCLHAAASGGNVECLNLLLSSGAD 448 Query: 235 PAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDS 287 R GRTPL A + A L GA E + + P ++ SD+ Sbjct: 449 LRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDT 501 Score = 48.5 bits (114), Expect = 7e-06 Identities = 57/218 (26%), Positives = 82/218 (37%), Gaps = 49/218 (22%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAER-RGHTALHLACRVGAHACARA 113 +D+++ G+TAL LA G T VE L A GA + ER R T LH A G Sbjct: 611 LDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 670 Query: 114 LLQPRPRRP-REAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172 L+ R + D Y Sbjct: 671 LIDSGERADITDVMDAY------------------------------------------- 687 Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232 G TPL +A+++ V+ V LL + G+ D + GR+ LH D L LL Sbjct: 688 --GQTPLMLAIMNGHVDCVHLLLEKGSTADAAD-LRGRTALHRGAVTGCEDCLAALLDHD 744 Query: 233 ANPAARMYGGRTPLG-SAMLRPNPILARLLRAHGAPEP 269 A R + GRTP+ ++ +L LL+A + +P Sbjct: 745 AFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDP 782 Score = 45.1 bits (105), Expect = 8e-05 Identities = 46/177 (25%), Positives = 75/177 (42%), Gaps = 22/177 (12%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGL----CVAERRGHTALHLACRVGAHACARALLQP 117 G+T +HLA+ G T+ + L A + G++ +H A G C LL+ Sbjct: 754 GRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE- 812 Query: 118 RPRRPREAPDTYLAQGPDRTPDTNHTPV--ALYPDSDLEKEEEESEEDWKLQLEAENYEG 175 +P +YL P TP+ A+ + D E K+ + + + +G Sbjct: 813 ------HSPFSYLEGNP-------FTPLHCAVINNQDSTTEMLLGALGAKI-VNSRDAKG 858 Query: 176 HTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232 TPLH A +V +R+L A+++ + T GR+ L A E +E LL G Sbjct: 859 RTPLHAAAFADNVSGLRMLLQHQAEVNATDHT-GRTALMTAAENGQTAAVEFLLYRG 914 Score = 43.5 bits (101), Expect = 2e-04 Identities = 31/81 (38%), Positives = 41/81 (50%), Gaps = 4/81 (4%) Query: 36 SSSATSLRMGTRFSAGTEYMDLQNDLGQTALHLAAILGETSTVE-KLYAAGAGLCVAERR 94 + + + LRM + A D G+TAL AA G+T+ VE LY A L V + Sbjct: 868 ADNVSGLRMLLQHQAEVNATD---HTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDEN 924 Query: 95 GHTALHLACRVGAHACARALL 115 +TALHLAC G CA +L Sbjct: 925 KNTALHLACSKGHEKCALMIL 945 Score = 42.4 bits (98), Expect = 5e-04 Identities = 32/89 (35%), Positives = 44/89 (49%), Gaps = 1/89 (1%) Query: 178 PLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAA 237 PL A+ +DVE VR L +++ + R+PLH A +L+LLL +GAN A Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQE-RRTPLHAAAYVGDVPILQLLLMSGANVNA 69 Query: 238 RMYGGRTPLGSAMLRPNPILARLLRAHGA 266 + TPL A N + LL AH A Sbjct: 70 KDTLWLTPLHRAAASRNEKVLGLLLAHSA 98 Score = 42.0 bits (97), Expect = 7e-04 Identities = 32/91 (35%), Positives = 47/91 (51%), Gaps = 1/91 (1%) Query: 156 EEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHL 215 EE S K + + E TPLH A DV +++LL +GA+++ + T +PLH Sbjct: 22 EEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD-TLWLTPLHR 80 Query: 216 AVEAQAADVLELLLRAGANPAARMYGGRTPL 246 A ++ VL LLL A+ AR +TPL Sbjct: 81 AAASRNEKVLGLLLAHSADVNARDKLWQTPL 111 Score = 37.4 bits (85), Expect = 0.017 Identities = 48/186 (25%), Positives = 67/186 (36%), Gaps = 17/186 (9%) Query: 64 TALHLAAILGETSTVEKLYAAGAGLCVAER--RGHTALHLACRVGAHACARALLQPRPRR 121 T LH A I + ST E L A V R +G T LH A + R LLQ + Sbjct: 825 TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAE- 883 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181 + T T T + ++ E K L + +T LH+ Sbjct: 884 ------------VNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHL 931 Query: 182 AVI--HKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARM 239 A H+ ++ L L + + PLH+A A V++ LL GA A Sbjct: 932 ACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVD 991 Query: 240 YGGRTP 245 G TP Sbjct: 992 EEGHTP 997 Score = 36.6 bits (83), Expect = 0.029 Identities = 46/193 (23%), Positives = 72/193 (37%), Gaps = 17/193 (8%) Query: 78 VEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRT 137 +E L GA + +R+G+TA+H A G LL+ + T Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592 Query: 138 PDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDA 197 H E ++ + + L+ +++G T L +A E V +L Sbjct: 593 AYNGHC------------EALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAH 640 Query: 198 GADLDKPEPTCGRSPLHLAVEAQAADVLELLL----RAGANPAARMYGGRTPLGSAMLRP 253 GA E +PLH A + D L LL+ RA Y G+TPL A++ Sbjct: 641 GASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAY-GQTPLMLAIMNG 699 Query: 254 NPILARLLRAHGA 266 + LL G+ Sbjct: 700 HVDCVHLLLEKGS 712 Score = 31.6 bits (70), Expect = 0.92 Identities = 24/70 (34%), Positives = 32/70 (45%), Gaps = 4/70 (5%) Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVG---AHACARALL 115 N Q LH+AA G S V+ L + GA + + GHT LAC A A L Sbjct: 958 NSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPA-LACAPNKDVADCLALILS 1016 Query: 116 QPRPRRPREA 125 +P P++A Sbjct: 1017 TMKPFPPKDA 1026 >gi|52486251 phospholipase A2, group VI isoform b [Homo sapiens] Length = 752 Score = 69.3 bits (168), Expect = 4e-12 Identities = 65/214 (30%), Positives = 94/214 (43%), Gaps = 20/214 (9%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYA--AGAGLCVAERRGHTALHLACRVGAHACAR 112 MD+ + G+T H A + G+ S V +L A AGL +G T LHLAC++G R Sbjct: 179 MDVTDYKGETVFHYA-VQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVR 237 Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172 LL R P+ Y + + + DS ++ + Sbjct: 238 VLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSS------------QIHSKDPR 285 Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232 Y G +PLH A K+ EM R+L G +++ + G + LH+AV D +LL G Sbjct: 286 Y-GASPLHWA---KNAEMARMLLKRGCNVNSTS-SAGNTALHVAVMRNRFDCAIVLLTHG 340 Query: 233 ANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 AN AR G TPL AM + N + + L GA Sbjct: 341 ANADARGEHGNTPLHLAMSKDNVEMIKALIVFGA 374 Score = 41.6 bits (96), Expect = 9e-04 Identities = 50/191 (26%), Positives = 81/191 (42%), Gaps = 26/191 (13%) Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115 N+ G T LHLA LG+ V L A + G+ +H A + CA ++ Sbjct: 217 NNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEMIISMD 275 Query: 116 --QPRPRRPRE-APDTYLAQGPD-------RTPDTNHTPVALYPDSDLEKEEEESEEDWK 165 Q + PR A + A+ + R + N T A ++ L + D Sbjct: 276 SSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSA--GNTALHVAVMRNRFDCA 333 Query: 166 LQL-------EAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLA-- 216 + L +A G+TPLH+A+ +VEM++ L GA++D P G +P LA Sbjct: 334 IVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPN-DFGETPTFLASK 392 Query: 217 VEAQAADVLEL 227 + Q D++ + Sbjct: 393 IGRQLQDLMHI 403 Score = 36.6 bits (83), Expect = 0.029 Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 7/96 (7%) Query: 170 AENYEGHTPLHVAVIHKDVE-MVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELL 228 AEN EG TPLH+A D E +V L++ +D + G + H AV+ + VL+LL Sbjct: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYK-GETVFHYAVQGDNSQVLQLL 205 Query: 229 LR---AGANPAARMYGGRTPLGSAMLRPNPILARLL 261 R AG N G TPL A + R+L Sbjct: 206 GRNAVAGLNQVNNQ--GLTPLHLACQLGKQEMVRVL 239 Score = 35.4 bits (80), Expect = 0.064 Identities = 50/222 (22%), Positives = 80/222 (36%), Gaps = 49/222 (22%) Query: 57 LQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQ 116 ++N + HLA LG C G T LHLACR G L+Q Sbjct: 114 IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQ 173 Query: 117 PRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176 HT Q++ +Y+G Sbjct: 174 -----------------------YCHT-----------------------QMDVTDYKGE 187 Query: 177 TPLHVAVIHKDVEMVRLL-RDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANP 235 T H AV + ++++LL R+A A L++ G +PLHLA + +++ +LL A Sbjct: 188 TVFHYAVQGDNSQVLQLLGRNAVAGLNQVN-NQGLTPLHLACQLGKQEMVRVLLLCNAR- 245 Query: 236 AARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSG 277 M P+ SAM A ++ + + + +D + G Sbjct: 246 CNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYG 287 Score = 28.5 bits (62), Expect = 7.8 Identities = 26/89 (29%), Positives = 36/89 (40%), Gaps = 11/89 (12%) Query: 29 RGCRGLPSSSA--TSLR---MGTRFSAGTEYM------DLQNDLGQTALHLAAILGETST 77 RGC +SSA T+L M RF + D + + G T LHLA Sbjct: 306 RGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEM 365 Query: 78 VEKLYAAGAGLCVAERRGHTALHLACRVG 106 ++ L GA + G T LA ++G Sbjct: 366 IKALIVFGAEVDTPNDFGETPTFLASKIG 394 >gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens] Length = 806 Score = 69.3 bits (168), Expect = 4e-12 Identities = 65/214 (30%), Positives = 94/214 (43%), Gaps = 20/214 (9%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYA--AGAGLCVAERRGHTALHLACRVGAHACAR 112 MD+ + G+T H A + G+ S V +L A AGL +G T LHLAC++G R Sbjct: 179 MDVTDYKGETVFHYA-VQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVR 237 Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172 LL R P+ Y + + + DS ++ + Sbjct: 238 VLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSS------------QIHSKDPR 285 Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232 Y G +PLH A K+ EM R+L G +++ + G + LH+AV D +LL G Sbjct: 286 Y-GASPLHWA---KNAEMARMLLKRGCNVNSTS-SAGNTALHVAVMRNRFDCAIVLLTHG 340 Query: 233 ANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266 AN AR G TPL AM + N + + L GA Sbjct: 341 ANADARGEHGNTPLHLAMSKDNVEMIKALIVFGA 374 Score = 41.2 bits (95), Expect = 0.001 Identities = 48/178 (26%), Positives = 75/178 (42%), Gaps = 24/178 (13%) Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115 N+ G T LHLA LG+ V L A + G+ +H A + CA ++ Sbjct: 217 NNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEMIISMD 275 Query: 116 --QPRPRRPRE-APDTYLAQGPD-------RTPDTNHTPVALYPDSDLEKEEEESEEDWK 165 Q + PR A + A+ + R + N T A ++ L + D Sbjct: 276 SSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSA--GNTALHVAVMRNRFDCA 333 Query: 166 LQL-------EAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLA 216 + L +A G+TPLH+A+ +VEM++ L GA++D P G +P LA Sbjct: 334 IVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPN-DFGETPTFLA 390 Score = 36.6 bits (83), Expect = 0.029 Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 7/96 (7%) Query: 170 AENYEGHTPLHVAVIHKDVE-MVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELL 228 AEN EG TPLH+A D E +V L++ +D + G + H AV+ + VL+LL Sbjct: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYK-GETVFHYAVQGDNSQVLQLL 205 Query: 229 LR---AGANPAARMYGGRTPLGSAMLRPNPILARLL 261 R AG N G TPL A + R+L Sbjct: 206 GRNAVAGLNQVNNQ--GLTPLHLACQLGKQEMVRVL 239 Score = 35.4 bits (80), Expect = 0.064 Identities = 50/222 (22%), Positives = 80/222 (36%), Gaps = 49/222 (22%) Query: 57 LQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQ 116 ++N + HLA LG C G T LHLACR G L+Q Sbjct: 114 IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQ 173 Query: 117 PRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176 HT Q++ +Y+G Sbjct: 174 -----------------------YCHT-----------------------QMDVTDYKGE 187 Query: 177 TPLHVAVIHKDVEMVRLL-RDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANP 235 T H AV + ++++LL R+A A L++ G +PLHLA + +++ +LL A Sbjct: 188 TVFHYAVQGDNSQVLQLLGRNAVAGLNQVN-NQGLTPLHLACQLGKQEMVRVLLLCNAR- 245 Query: 236 AARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSG 277 M P+ SAM A ++ + + + +D + G Sbjct: 246 CNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYG 287 Score = 30.8 bits (68), Expect = 1.6 Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 11/98 (11%) Query: 29 RGCRGLPSSSA--TSLR---MGTRFSAGTEYM------DLQNDLGQTALHLAAILGETST 77 RGC +SSA T+L M RF + D + + G T LHLA Sbjct: 306 RGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEM 365 Query: 78 VEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 ++ L GA + G T LA ++G +A+L Sbjct: 366 IKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAIL 403 >gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] Length = 951 Score = 66.6 bits (161), Expect = 3e-11 Identities = 62/239 (25%), Positives = 105/239 (43%), Gaps = 23/239 (9%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G+TA HLAA G + + G + + GH+ALHLA + H C R LLQ Sbjct: 53 GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ----- 107 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181 ++ P + D++ Y + + + + K + ++ +G+ PL + Sbjct: 108 ---------SKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 158 Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241 AV + E+ L D GAD++ + GR+ L LA E +++ +E L++ GA+ Sbjct: 159 AVQNGHSEICHFLLDHGADVNSRNKS-GRTALMLACEIGSSNAVEALIKKGADLNLVDSL 217 Query: 242 GRTPLGSAMLRPNPILARLLRAHGAPE--------PEGEDEKSGPCSSSSDSDSGDEGV 292 G L + L N + LL + + + P+ + S P S +S SG E V Sbjct: 218 GYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKESV 276 Score = 37.7 bits (86), Expect = 0.013 Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 10/90 (11%) Query: 58 QNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQP 117 +N G+TAL LA +G ++ VE L GA L + + G+ ALH + ++ +A ++LL Sbjct: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS-KLSENAGIQSLLLS 239 Query: 118 R---------PRRPREAPDTYLAQGPDRTP 138 + P +P++ D + TP Sbjct: 240 KISQDADLKTPTKPKQLSDVSSPRSITSTP 269 Score = 37.4 bits (85), Expect = 0.017 Identities = 41/164 (25%), Positives = 67/164 (40%), Gaps = 19/164 (11%) Query: 85 GAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPD--TNH 142 GA + G TA HLA G C R + + G D T T H Sbjct: 43 GASATKHDSEGKTAFHLAAAKGHVECLRVM---------------ITHGVDVTAQDTTGH 87 Query: 143 TPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLD 202 + + L + + + + K E+ + G T LH A ++ V++L + + ++ Sbjct: 88 SALHLAAKNSHHECIRKLLQS-KCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPIN 146 Query: 203 KPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 246 + G PL LAV+ +++ LL GA+ +R GRT L Sbjct: 147 LKD-LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189 >gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] Length = 983 Score = 65.9 bits (159), Expect = 4e-11 Identities = 54/229 (23%), Positives = 106/229 (46%), Gaps = 22/229 (9%) Query: 8 WAPWVRTQRPPEDLGWARSWARGCRGLPSSSATSLR--MGTRFSAGTEYMDLQNDLGQTA 65 + PW+ + + W ++ R + + + A + +G + ++ T++ + G+TA Sbjct: 5 YLPWLSAKEKKTN-EWNKNDDRLLQAVENGDAEKVASLLGKKGASATKH----DSEGKTA 59 Query: 66 LHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREA 125 HLAA G + + G + + GH+ALHLA + H C R LLQ Sbjct: 60 FHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ--------- 110 Query: 126 PDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIH 185 ++ P + D++ Y + + + + K + ++ +G+ PL +AV + Sbjct: 111 -----SKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQN 165 Query: 186 KDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234 E+ L D GAD++ + GR+ L LA E +++ +E L++ GA+ Sbjct: 166 GHSEICHFLLDHGADVNSRNKS-GRTALMLACEIGSSNAVEALIKKGAD 213 Score = 35.8 bits (81), Expect = 0.049 Identities = 21/58 (36%), Positives = 35/58 (60%), Gaps = 1/58 (1%) Query: 58 QNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 +N G+TAL LA +G ++ VE L GA L + + G+ ALH + ++ +A ++LL Sbjct: 184 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS-KLSENAGIQSLL 240 Score = 35.0 bits (79), Expect = 0.083 Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 1/94 (1%) Query: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233 EG T H+A VE +R++ G D+ + T G S LHLA + + + LL++ Sbjct: 55 EGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT-GHSALHLAAKNSHHECIRKLLQSKC 113 Query: 234 NPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267 + G+T L A + ++L H +P Sbjct: 114 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 147 >gi|55770876 notch4 preproprotein [Homo sapiens] Length = 2003 Score = 65.5 bits (158), Expect = 6e-11 Identities = 67/207 (32%), Positives = 86/207 (41%), Gaps = 14/207 (6%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G+T LHLAA + +L AGA +R G T LH A A + LL+ R Sbjct: 1634 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSR--- 1690 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181 + A D RT D TP+ L +E EE + + A + G T LH Sbjct: 1691 -QTAVDA-------RTED-GTTPLMLAARLAVEDLVEELIAA-QADVGARDKWGKTALHW 1740 Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241 A + R L AGAD D + ++PL LA A +V +LLL GA R Sbjct: 1741 AAAVNNARAARSLLQAGADKD-AQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQA 1799 Query: 242 GRTPLGSAMLRPNPILARLLRAHGAPE 268 G P A R + L LL G PE Sbjct: 1800 GLAPADVAHQRNHWDLLTLLEGAGPPE 1826 Score = 42.0 bits (97), Expect = 7e-04 Identities = 33/104 (31%), Positives = 46/104 (44%) Query: 175 GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234 G TPLH AV E+ +LL + G +PL LA D++E L+ A A+ Sbjct: 1667 GRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQAD 1726 Query: 235 PAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 278 AR G+T L A N AR L GA + ++ + P Sbjct: 1727 VGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTP 1770 Score = 41.6 bits (96), Expect = 9e-04 Identities = 51/184 (27%), Positives = 72/184 (39%), Gaps = 49/184 (26%) Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114 +D + + G T L LAA L VE+L AA A + ++ G TALH A V AR+L Sbjct: 1694 VDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSL 1753 Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 174 LQ G D+ +A++ Sbjct: 1754 LQ---------------AGADK--------------------------------DAQDNR 1766 Query: 175 GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234 TPL +A VE+ +LL GA + + G +P +A + D+L LL AG Sbjct: 1767 EQTPLFLAAREGAVEVAQLLLGLGAARELRD-QAGLAPADVAHQRNHWDLLTLLEGAGP- 1824 Query: 235 PAAR 238 P AR Sbjct: 1825 PEAR 1828 Score = 39.3 bits (90), Expect = 0.004 Identities = 38/118 (32%), Positives = 49/118 (41%), Gaps = 20/118 (16%) Query: 149 PDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEP-- 206 P + + +ESE + L+ +G TPL AV +V+ GA L PEP Sbjct: 1562 PQAAMLTPPQESEMEAP-DLDTRGPDGVTPLMSAVCCGEVQSGTF---QGAWLGCPEPWE 1617 Query: 207 ------TC--------GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAM 250 C G +PLHLA LL AGANP GRTPL +A+ Sbjct: 1618 PLLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAV 1675 >gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] Length = 972 Score = 65.5 bits (158), Expect = 6e-11 Identities = 47/173 (27%), Positives = 82/173 (47%), Gaps = 15/173 (8%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G+TA HLAA G + + G + + GH+ALHLA + H C R LLQ Sbjct: 45 GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ----- 99 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181 ++ P + D++ Y + + + + K + ++ +G+ PL + Sbjct: 100 ---------SKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 150 Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234 AV + E+ L D GAD++ + GR+ L LA E +++ +E L++ GA+ Sbjct: 151 AVQNGHSEICHFLLDHGADVNSRNKS-GRTALMLACEIGSSNAVEALIKKGAD 202 Score = 35.8 bits (81), Expect = 0.049 Identities = 21/58 (36%), Positives = 35/58 (60%), Gaps = 1/58 (1%) Query: 58 QNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 +N G+TAL LA +G ++ VE L GA L + + G+ ALH + ++ +A ++LL Sbjct: 173 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS-KLSENAGIQSLL 229 Score = 35.0 bits (79), Expect = 0.083 Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 1/94 (1%) Query: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233 EG T H+A VE +R++ G D+ + T G S LHLA + + + LL++ Sbjct: 44 EGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT-GHSALHLAAKNSHHECIRKLLQSKC 102 Query: 234 NPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267 + G+T L A + ++L H +P Sbjct: 103 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 136 >gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] Length = 980 Score = 65.5 bits (158), Expect = 6e-11 Identities = 47/173 (27%), Positives = 82/173 (47%), Gaps = 15/173 (8%) Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121 G+TA HLAA G + + G + + GH+ALHLA + H C R LLQ Sbjct: 53 GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ----- 107 Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181 ++ P + D++ Y + + + + K + ++ +G+ PL + Sbjct: 108 ---------SKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 158 Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234 AV + E+ L D GAD++ + GR+ L LA E +++ +E L++ GA+ Sbjct: 159 AVQNGHSEICHFLLDHGADVNSRNKS-GRTALMLACEIGSSNAVEALIKKGAD 210 Score = 35.8 bits (81), Expect = 0.049 Identities = 21/58 (36%), Positives = 35/58 (60%), Gaps = 1/58 (1%) Query: 58 QNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115 +N G+TAL LA +G ++ VE L GA L + + G+ ALH + ++ +A ++LL Sbjct: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS-KLSENAGIQSLL 237 Score = 35.0 bits (79), Expect = 0.083 Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 1/94 (1%) Query: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233 EG T H+A VE +R++ G D+ + T G S LHLA + + + LL++ Sbjct: 52 EGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT-GHSALHLAAKNSHHECIRKLLQSKC 110 Query: 234 NPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267 + G+T L A + ++L H +P Sbjct: 111 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 144 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.313 0.131 0.397 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,566,283 Number of Sequences: 37866 Number of extensions: 796723 Number of successful extensions: 7525 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 334 Number of HSP's successfully gapped in prelim test: 100 Number of HSP's that attempted gapping in prelim test: 4135 Number of HSP's gapped (non-prelim): 2094 length of query: 306 length of database: 18,247,518 effective HSP length: 102 effective length of query: 204 effective length of database: 14,385,186 effective search space: 2934577944 effective search space used: 2934577944 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.