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Search of human proteins with 48928017
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|48928017 nuclear factor of kappa light polypeptide gene
enhancer in B-cells inhibitor, beta isoform b [Homo sapiens]
(306 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|48928017 nuclear factor of kappa light polypeptide gene enhan... 627 e-180
gi|21361135 nuclear factor of kappa light polypeptide gene enhan... 497 e-141
gi|71274109 nuclear factor of kappa light polypeptide gene enhan... 113 2e-25
gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens] 107 1e-23
gi|117320531 nuclear factor of kappa light polypeptide gene enha... 102 6e-22
gi|117320540 nuclear factor of kappa light polypeptide gene enha... 102 6e-22
gi|117320527 nuclear factor of kappa light polypeptide gene enha... 102 6e-22
gi|10092619 nuclear factor of kappa light polypeptide gene enhan... 98 1e-20
gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens] 82 6e-16
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 75 7e-14
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 73 3e-13
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 73 3e-13
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 73 3e-13
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 72 6e-13
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 72 6e-13
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 72 6e-13
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 72 6e-13
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 72 6e-13
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 71 1e-12
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 71 1e-12
gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3... 71 1e-12
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 70 2e-12
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 70 2e-12
gi|52486251 phospholipase A2, group VI isoform b [Homo sapiens] 69 4e-12
gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens] 69 4e-12
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 67 3e-11
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 66 4e-11
gi|55770876 notch4 preproprotein [Homo sapiens] 65 6e-11
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 65 6e-11
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 65 6e-11
>gi|48928017 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, beta isoform b [Homo sapiens]
Length = 306
Score = 627 bits (1617), Expect = e-180
Identities = 306/306 (100%), Positives = 306/306 (100%)
Query: 1 MNGATAAWAPWVRTQRPPEDLGWARSWARGCRGLPSSSATSLRMGTRFSAGTEYMDLQND 60
MNGATAAWAPWVRTQRPPEDLGWARSWARGCRGLPSSSATSLRMGTRFSAGTEYMDLQND
Sbjct: 1 MNGATAAWAPWVRTQRPPEDLGWARSWARGCRGLPSSSATSLRMGTRFSAGTEYMDLQND 60
Query: 61 LGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPR 120
LGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPR
Sbjct: 61 LGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPR 120
Query: 121 RPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLH 180
RPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLH
Sbjct: 121 RPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLH 180
Query: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240
VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY
Sbjct: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240
Query: 241 GGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGS 300
GGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGS
Sbjct: 241 GGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGS 300
Query: 301 PAGGSG 306
PAGGSG
Sbjct: 301 PAGGSG 306
>gi|21361135 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, beta isoform a [Homo sapiens]
Length = 356
Score = 497 bits (1279), Expect = e-141
Identities = 244/244 (100%), Positives = 244/244 (100%)
Query: 48 FSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGA 107
FSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGA
Sbjct: 80 FSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGA 139
Query: 108 HACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQ 167
HACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQ
Sbjct: 140 HACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQ 199
Query: 168 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL 227
LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL
Sbjct: 200 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL 259
Query: 228 LLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDS 287
LLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDS
Sbjct: 260 LLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDS 319
Query: 288 GDEG 291
GDEG
Sbjct: 320 GDEG 323
Score = 34.7 bits (78), Expect = 0.11
Identities = 39/143 (27%), Positives = 52/143 (36%), Gaps = 25/143 (17%)
Query: 174 EGHTPLHVAVIHKDVEMVRLLR--DAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231
+G T LH+AVIH+ + L AG + + G++ LHLA +E L A
Sbjct: 57 DGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 116
Query: 232 GANPAARMYGGRTPL-----------GSAMLRPNPILARLLRAHGAPE-------PEGED 273
GA G T L A+L+P P R AP+ D
Sbjct: 117 GAGLCVAERRGHTALHLACRVGAHACARALLQPRP-----RRPREAPDTYLAQGPDRTPD 171
Query: 274 EKSGPCSSSSDSDSGDEGVSQEE 296
P + DSD E EE
Sbjct: 172 TNHTPVALYPDSDLEKEEEESEE 194
>gi|71274109 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, epsilon [Homo sapiens]
Length = 500
Score = 113 bits (282), Expect = 2e-25
Identities = 72/194 (37%), Positives = 99/194 (51%), Gaps = 37/194 (19%)
Query: 53 EYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACAR 112
E +D+QN+L QTALHLA L + V L GA + +R G TALH+AC+ ACAR
Sbjct: 285 EVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACAR 344
Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
LL+ RP R T+H+ L L+ +N
Sbjct: 345 CLLEGRPEPGR---------------GTSHS----------------------LDLQLQN 367
Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232
++G LH+A + K+ ++ LL GAD+D E T G++ LHLAVE Q +++ LL+AG
Sbjct: 368 WQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAG 427
Query: 233 ANPAARMYGGRTPL 246
A ARM G TPL
Sbjct: 428 AQVDARMLNGCTPL 441
Score = 35.8 bits (81), Expect = 0.049
Identities = 36/110 (32%), Positives = 50/110 (45%), Gaps = 11/110 (10%)
Query: 167 QLEAENY---EGHTPLHVAVIHKDVEMV----RLLRDAGADLDKPEPTCGRSPLHLAVEA 219
QLEA Y +G T +H+AVIH+ ++ LL D+ ++ LHLAV
Sbjct: 248 QLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQN---NLYQTALHLAVHL 304
Query: 220 QAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEP 269
+ L+ GA+ A + G T L A R + AR L G PEP
Sbjct: 305 DQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCL-LEGRPEP 353
>gi|164664508 B-cell CLL/lymphoma 3 [Homo sapiens]
Length = 454
Score = 107 bits (268), Expect = 1e-23
Identities = 83/224 (37%), Positives = 102/224 (45%), Gaps = 43/224 (19%)
Query: 43 RMGTRFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLA 102
R+ F G +D+ N+L QT LHLA I S V L AGA +R G TA HLA
Sbjct: 153 RLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLA 212
Query: 103 CRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEE 162
C + C RALL AP T
Sbjct: 213 CEHRSPTCLRALLDSA------APGT---------------------------------- 232
Query: 163 DWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAA 222
L LEA NY+G T LHVAV + E V+LL + GAD+D + GRSPL AVE +
Sbjct: 233 ---LDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSL 289
Query: 223 DVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
+++LLL+ GAN A+MY G + L SA R L R L GA
Sbjct: 290 SMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGA 333
Score = 49.3 bits (116), Expect = 4e-06
Identities = 34/98 (34%), Positives = 49/98 (50%), Gaps = 5/98 (5%)
Query: 174 EGHTPLHVAVIHKDV----EMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLL 229
+G TPLH+AV+ ++ +V L + G +LD ++PLHLAV V+ LL+
Sbjct: 134 DGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYN-NLRQTPLHLAVITTLPSVVRLLV 192
Query: 230 RAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
AGA+P A G+T A +P R L AP
Sbjct: 193 TAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAP 230
>gi|117320531 nuclear factor of kappa light polypeptide gene
enhancer in B-cells 2 isoform a [Homo sapiens]
Length = 900
Score = 102 bits (253), Expect = 6e-22
Identities = 85/248 (34%), Positives = 111/248 (44%), Gaps = 47/248 (18%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHA--CAR 112
++L N L QT LHLA I G+TS V L GA + +R G +A+HLA R GA A R
Sbjct: 520 VNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLR 579
Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
ALLQ G P H P +
Sbjct: 580 ALLQ---------------SGAPAVPQLLHMP---------------------------D 597
Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAAD-VLELLLRA 231
+EG P+H+AV + E + LL D+GA+++ E GR+ LHLA E + V L+ +
Sbjct: 598 FEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKL 657
Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSS--SSDSDSGD 289
AN AR + G TPL A P L RLL GA +E P S +SDSDS
Sbjct: 658 RANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDS 717
Query: 290 EGVSQEER 297
EG ++ R
Sbjct: 718 EGPEKDTR 725
Score = 45.4 bits (106), Expect = 6e-05
Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 7/107 (6%)
Query: 168 LEAENYEGHTPLHVAVIHKD---VEMVRLLRDAGADLDKPEPT--CGRSPLHLAVEAQAA 222
L A++ G TPLH+A+IH +E + + DL T ++PLHLAV
Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540
Query: 223 DVLELLLRAGANPAARMYGGRTPLGSAML--RPNPILARLLRAHGAP 267
V+ LLR GA+PA G + + A+ P L R L GAP
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP 587
Score = 43.5 bits (101), Expect = 2e-04
Identities = 75/286 (26%), Positives = 105/286 (36%), Gaps = 58/286 (20%)
Query: 50 AGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA-AGAGLCVAERRGHTALHLACRVGAH 108
+G E + G+TALHLA + E V L A + G+T LHLA +G
Sbjct: 622 SGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYP 681
Query: 109 ACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH--TPVALYPDSDLEKEEEESEEDWKL 166
R LL+ G D + P+ P SD + + E E+D +
Sbjct: 682 TLTRLLLK---------------AGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTR- 725
Query: 167 QLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPL--HLAVEAQAADV 224
++ GHTPL + ++ LL +A + +P P SP L++ A
Sbjct: 726 ----SSFRGHTPLDLTC---STKVKTLLLNAAQNTMEP-PLTPPSPAGPGLSLGDTALQN 777
Query: 225 LELLL--------------RAGANPAARMYGGRTPLGSAMLRPNPI----LARLLRA--- 263
LE LL R G Y T ++LR + LA LL A
Sbjct: 778 LEQLLDGPEAQGSWAELAERLGLRSLVDTYRQTTSPSGSLLRSYELAGGDLAGLLEALSD 837
Query: 264 HGAPE-------PEGEDEKSGPCSSSSDSDSGDEGVSQE-ERQGSP 301
G E PE D+ DS G + V QE E+ G P
Sbjct: 838 MGLEEGVRLLRGPETRDKLPSTAEVKEDSAYGSQSVEQEAEKLGPP 883
>gi|117320540 nuclear factor of kappa light polypeptide gene
enhancer in B-cells 2 isoform b [Homo sapiens]
Length = 899
Score = 102 bits (253), Expect = 6e-22
Identities = 85/248 (34%), Positives = 111/248 (44%), Gaps = 47/248 (18%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHA--CAR 112
++L N L QT LHLA I G+TS V L GA + +R G +A+HLA R GA A R
Sbjct: 520 VNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLR 579
Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
ALLQ G P H P +
Sbjct: 580 ALLQ---------------SGAPAVPQLLHMP---------------------------D 597
Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAAD-VLELLLRA 231
+EG P+H+AV + E + LL D+GA+++ E GR+ LHLA E + V L+ +
Sbjct: 598 FEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKL 657
Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSS--SSDSDSGD 289
AN AR + G TPL A P L RLL GA +E P S +SDSDS
Sbjct: 658 RANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDS 717
Query: 290 EGVSQEER 297
EG ++ R
Sbjct: 718 EGPEKDTR 725
Score = 45.4 bits (106), Expect = 6e-05
Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 7/107 (6%)
Query: 168 LEAENYEGHTPLHVAVIHKD---VEMVRLLRDAGADLDKPEPT--CGRSPLHLAVEAQAA 222
L A++ G TPLH+A+IH +E + + DL T ++PLHLAV
Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540
Query: 223 DVLELLLRAGANPAARMYGGRTPLGSAML--RPNPILARLLRAHGAP 267
V+ LLR GA+PA G + + A+ P L R L GAP
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP 587
Score = 39.7 bits (91), Expect = 0.003
Identities = 76/286 (26%), Positives = 105/286 (36%), Gaps = 59/286 (20%)
Query: 50 AGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA-AGAGLCVAERRGHTALHLACRVGAH 108
+G E + G+TALHLA + E V L A + G+T LHLA +G
Sbjct: 622 SGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYP 681
Query: 109 ACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH--TPVALYPDSDLEKEEEESEEDWKL 166
R LL+ G D + P+ P SD + + E E+D +
Sbjct: 682 TLTRLLLK---------------AGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTR- 725
Query: 167 QLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPL--HLAVEAQAADV 224
++ GHTPL + ++ LL +A + +P P SP L++ A
Sbjct: 726 ----SSFRGHTPLDLTC---STKVKTLLLNAAQNTMEP-PLTPPSPAGPGLSLGDTALQN 777
Query: 225 LELLL--------------RAGANPAARMYGGRTPLGSAMLRPNPI----LARLLRA--- 263
LE LL R G Y T ++LR + LA LL A
Sbjct: 778 LEQLLDGPEAQGSWAELAERLGLRSLVDTYRQTTSPSGSLLRSYELAGGDLAGLLEALSD 837
Query: 264 HGAPE-------PEGEDEKSGPCSSSSDSDSGDEGVSQE-ERQGSP 301
G E PE D K DS G + V QE E+ G P
Sbjct: 838 MGLEEGVRLLRGPETRD-KLPSTEVKEDSAYGSQSVEQEAEKLGPP 882
>gi|117320527 nuclear factor of kappa light polypeptide gene
enhancer in B-cells 2 isoform b [Homo sapiens]
Length = 899
Score = 102 bits (253), Expect = 6e-22
Identities = 85/248 (34%), Positives = 111/248 (44%), Gaps = 47/248 (18%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHA--CAR 112
++L N L QT LHLA I G+TS V L GA + +R G +A+HLA R GA A R
Sbjct: 520 VNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLR 579
Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
ALLQ G P H P +
Sbjct: 580 ALLQ---------------SGAPAVPQLLHMP---------------------------D 597
Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAAD-VLELLLRA 231
+EG P+H+AV + E + LL D+GA+++ E GR+ LHLA E + V L+ +
Sbjct: 598 FEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKL 657
Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSS--SSDSDSGD 289
AN AR + G TPL A P L RLL GA +E P S +SDSDS
Sbjct: 658 RANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDS 717
Query: 290 EGVSQEER 297
EG ++ R
Sbjct: 718 EGPEKDTR 725
Score = 45.4 bits (106), Expect = 6e-05
Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 7/107 (6%)
Query: 168 LEAENYEGHTPLHVAVIHKD---VEMVRLLRDAGADLDKPEPT--CGRSPLHLAVEAQAA 222
L A++ G TPLH+A+IH +E + + DL T ++PLHLAV
Sbjct: 481 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 540
Query: 223 DVLELLLRAGANPAARMYGGRTPLGSAML--RPNPILARLLRAHGAP 267
V+ LLR GA+PA G + + A+ P L R L GAP
Sbjct: 541 SVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP 587
Score = 39.7 bits (91), Expect = 0.003
Identities = 76/286 (26%), Positives = 105/286 (36%), Gaps = 59/286 (20%)
Query: 50 AGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA-AGAGLCVAERRGHTALHLACRVGAH 108
+G E + G+TALHLA + E V L A + G+T LHLA +G
Sbjct: 622 SGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYP 681
Query: 109 ACARALLQPRPRRPREAPDTYLAQGPDRTPDTNH--TPVALYPDSDLEKEEEESEEDWKL 166
R LL+ G D + P+ P SD + + E E+D +
Sbjct: 682 TLTRLLLK---------------AGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTR- 725
Query: 167 QLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPL--HLAVEAQAADV 224
++ GHTPL + ++ LL +A + +P P SP L++ A
Sbjct: 726 ----SSFRGHTPLDLTC---STKVKTLLLNAAQNTMEP-PLTPPSPAGPGLSLGDTALQN 777
Query: 225 LELLL--------------RAGANPAARMYGGRTPLGSAMLRPNPI----LARLLRA--- 263
LE LL R G Y T ++LR + LA LL A
Sbjct: 778 LEQLLDGPEAQGSWAELAERLGLRSLVDTYRQTTSPSGSLLRSYELAGGDLAGLLEALSD 837
Query: 264 HGAPE-------PEGEDEKSGPCSSSSDSDSGDEGVSQE-ERQGSP 301
G E PE D K DS G + V QE E+ G P
Sbjct: 838 MGLEEGVRLLRGPETRD-KLPSTEVKEDSAYGSQSVEQEAEKLGPP 882
>gi|10092619 nuclear factor of kappa light polypeptide gene enhancer
in B-cells inhibitor, alpha [Homo sapiens]
Length = 317
Score = 97.8 bits (242), Expect = 1e-20
Identities = 78/241 (32%), Positives = 104/241 (43%), Gaps = 45/241 (18%)
Query: 54 YMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARA 113
+++ QN+L QT LHLA I + E L AG + + RG+T LHLAC G A
Sbjct: 103 FLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGV 162
Query: 114 LLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENY 173
L Q TP + L+A NY
Sbjct: 163 LTQSCT-----------------TPHLHSI------------------------LKATNY 181
Query: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233
GHT LH+A IH + +V LL GAD++ EP GR+ LHLAV+ Q D++ LLL+ GA
Sbjct: 182 NGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGA 241
Query: 234 NPAARMYGGRTPL----GSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGD 289
+ Y G +P G R L +L + PE EDE+S S + D
Sbjct: 242 DVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTED 301
Query: 290 E 290
E
Sbjct: 302 E 302
Score = 50.1 bits (118), Expect = 2e-06
Identities = 32/95 (33%), Positives = 50/95 (52%), Gaps = 6/95 (6%)
Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEM-VRLLRDAGADLD--KPEPTCGRS 211
+E E WK QL + G + LH+A+IH++ + + ++R DL + ++
Sbjct: 57 QEVPRGSEPWKQQLTED---GDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQT 113
Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 246
PLHLAV ++ E LL AG +P R + G TPL
Sbjct: 114 PLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPL 148
>gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]
Length = 969
Score = 82.0 bits (201), Expect = 6e-16
Identities = 73/241 (30%), Positives = 103/241 (42%), Gaps = 45/241 (18%)
Query: 53 EYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACAR 112
+ ++++NDL QT LHLA I + VE L AGA L + +R G++ LHLA + G
Sbjct: 574 DIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLS 633
Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
LL+ H AL L+ N
Sbjct: 634 ILLK-------------------------HKKAALL-------------------LDHPN 649
Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE-LLLRA 231
+G +H+A++ + + LL AGAD++ E GR+ LHLAVE + LLL
Sbjct: 650 GDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEG 709
Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEG 291
A+ + Y G TPL A R + LA LL+A GA E S ++ DEG
Sbjct: 710 DAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEG 769
Query: 292 V 292
V
Sbjct: 770 V 770
Score = 40.4 bits (93), Expect = 0.002
Identities = 25/69 (36%), Positives = 40/69 (57%), Gaps = 5/69 (7%)
Query: 171 ENYEGHTPLHVAVIHKDVEMVRLLRDAGA-----DLDKPEPTCGRSPLHLAVEAQAADVL 225
++ G + LH+A+IH ++VR L + + D+ ++PLHLAV + DV+
Sbjct: 540 QDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVV 599
Query: 226 ELLLRAGAN 234
E LLRAGA+
Sbjct: 600 EDLLRAGAD 608
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 75.1 bits (183), Expect = 7e-14
Identities = 70/227 (30%), Positives = 96/227 (42%), Gaps = 26/227 (11%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T +H+AA +G + V +L GA RG TALH+A R G R L+Q +
Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 492
Query: 122 PREAPD------------------TYLAQG--PDRTPDTNHTPVALYPDSDLEKEEEESE 161
+A D L QG P+ + +TP+ L S E E+ +
Sbjct: 493 EAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHL---SAREGHEDVAA 549
Query: 162 --EDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEA 219
D L +G TPLHVA + +E+ LL A D + G +PLH+A
Sbjct: 550 FLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKS-GLTPLHVAAHY 608
Query: 220 QAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
V LLL GA+P A G TPL A + +A L +GA
Sbjct: 609 DNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGA 655
Score = 58.9 bits (141), Expect = 5e-09
Identities = 54/228 (23%), Positives = 97/228 (42%), Gaps = 16/228 (7%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
+D G TALH+A++ G+ V+ L GA + + G T L++A + + L
Sbjct: 100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159
Query: 115 LQPRPRRPREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDW 164
L + D + L QG D+ + + P + +++++
Sbjct: 160 LDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAA 219
Query: 165 KL-----QLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEA 219
L + E+ G TPLH+A + ++ + LL + A +D +PLH+A +
Sbjct: 220 LLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN-DITPLHVASKR 278
Query: 220 QAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
A++++LLL GA A+ G TPL + + +L AP
Sbjct: 279 GNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326
Score = 58.9 bits (141), Expect = 5e-09
Identities = 59/225 (26%), Positives = 90/225 (40%), Gaps = 22/225 (9%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPR- 120
G T LHL+A G L GA L + ++G T LH+A + G A LLQ
Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP 591
Query: 121 --------RPREAPDTY---------LAQG--PDRTPDTNHTPVALYPDSDLEKEEEESE 161
P Y L QG P +TP+ + + + + +
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN-QMDIATTL 650
Query: 162 EDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQA 221
++ A +G +H+A V+MV LL A+++ + G +PLHLA +
Sbjct: 651 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS-GLTPLHLAAQEDR 709
Query: 222 ADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
+V E+L+ GA+ A+ G TPL N + L H A
Sbjct: 710 VNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSA 754
Score = 51.2 bits (121), Expect = 1e-06
Identities = 49/188 (26%), Positives = 77/188 (40%), Gaps = 15/188 (7%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH+AA + L GA R+G ++HLA + G H +LL R
Sbjct: 631 GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEG-HVDMVSLLLGRNAN 689
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
+ + L TP+ L D E ++A+ G+TPLHV
Sbjct: 690 VNLSNKSGL------------TPLHLAAQEDRVNVAEVLVNQGA-HVDAQTKMGYTPLHV 736
Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
+ ++++V L A ++ G +PLH A + ++ +LL+ A+P
Sbjct: 737 GCHYGNIKIVNFLLQHSAKVNAKTKN-GYTPLHQAAQQGHTHIINVLLQNNASPNELTVN 795
Query: 242 GRTPLGSA 249
G T LG A
Sbjct: 796 GNTALGIA 803
Score = 49.7 bits (117), Expect = 3e-06
Identities = 59/232 (25%), Positives = 87/232 (37%), Gaps = 26/232 (11%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
+++ N G ALHLA+ G V +L A + A ++G+TALH+A G + L
Sbjct: 67 INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126
Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 174
+ ++ + + NH V + D + + ED L +
Sbjct: 127 VTNGANVNAQSQNGFTPL--YMAAQENHLEVVKFL-LDNGASQSLATEDGFTPLAVALQQ 183
Query: 175 GH------------------TPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSPLH 214
GH LH+A D + LL D AD+ E G +PLH
Sbjct: 184 GHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADV---ESKSGFTPLH 240
Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
+A +V LLL A TPL A R N + +LL GA
Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGA 292
Score = 49.3 bits (116), Expect = 4e-06
Identities = 49/205 (23%), Positives = 75/205 (36%), Gaps = 48/205 (23%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH+A +E L GA + G T +H+A +G L+
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM------ 453
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
+ P+ T N G T LH+
Sbjct: 454 -------HHGASPNTT----------------------------------NVRGETALHM 472
Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
A E+VR L GA ++ + ++PLH++ AD+++ LL+ GA+P A
Sbjct: 473 AARSGQAEVVRYLVQDGAQVE-AKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS 531
Query: 242 GRTPLGSAMLRPNPILARLLRAHGA 266
G TPL + + +A L HGA
Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGA 556
Score = 48.5 bits (114), Expect = 7e-06
Identities = 55/223 (24%), Positives = 86/223 (38%), Gaps = 16/223 (7%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
+D + G T LH A G VE L A + + G + LH+A + C + L
Sbjct: 294 IDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLL 353
Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 174
LQ D A H VA + D K A+
Sbjct: 354 LQHNVPVDDVTNDYLTALHV--AAHCGHYKVA------------KVLLDKKANPNAKALN 399
Query: 175 GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
G TPLH+A ++++ LL GA + + G +P+H+A +++ L+ GA+
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTES-GLTPIHVAAFMGHVNIVSQLMHHGAS 458
Query: 235 PAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDEKS 276
P G T L A + R L GA E + +D+++
Sbjct: 459 PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQT 501
Score = 47.8 bits (112), Expect = 1e-05
Identities = 51/222 (22%), Positives = 81/222 (36%), Gaps = 29/222 (13%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
D G T LH+AA L GA A + G+T LH+A +
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAK----------- 640
Query: 116 QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-------KLQL 168
+ + T L G D T +++ + +E D +
Sbjct: 641 ----KNQMDIATTLLEYGADANAVTRQGIASVHLAA------QEGHVDMVSLLLGRNANV 690
Query: 169 EAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELL 228
N G TPLH+A V + +L + GA +D + G +PLH+ ++ L
Sbjct: 691 NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDA-QTKMGYTPLHVGCHYGNIKIVNFL 749
Query: 229 LRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPE 270
L+ A A+ G TPL A + + + +L + A E
Sbjct: 750 LQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791
Score = 40.8 bits (94), Expect = 0.002
Identities = 31/97 (31%), Positives = 48/97 (49%), Gaps = 1/97 (1%)
Query: 172 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231
N G LH+A VE+V L A++D G + LH+A A A+V+++L+
Sbjct: 71 NQNGLNALHLASKEGHVEVVSELLQREANVDAATKK-GNTALHIASLAGQAEVVKVLVTN 129
Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPE 268
GAN A+ G TPL A + + + L +GA +
Sbjct: 130 GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ 166
Score = 37.7 bits (86), Expect = 0.013
Identities = 22/62 (35%), Positives = 29/62 (46%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
++L N G T LHLAA + E L GA + + G+T LH+ C G L
Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749
Query: 115 LQ 116
LQ
Sbjct: 750 LQ 751
Score = 32.7 bits (73), Expect = 0.41
Identities = 19/63 (30%), Positives = 27/63 (42%)
Query: 54 YMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARA 113
++D Q +G T LH+ G V L A + + G+T LH A + G
Sbjct: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781
Query: 114 LLQ 116
LLQ
Sbjct: 782 LLQ 784
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 73.2 bits (178), Expect = 3e-13
Identities = 66/217 (30%), Positives = 93/217 (42%), Gaps = 27/217 (12%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
D+ N G+TALH+AA G+ V L GA + R T LH+A R+G + LL
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 496
Query: 116 QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEA----- 170
Q ++A PD +TP+ + E + + LEA
Sbjct: 497 Q------------HMAH-PDAATTNGYTPLHI-------SAREGQVDVASVLLEAGAAHS 536
Query: 171 -ENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLL 229
+G TPLHVA + +++ +LL A D G +PLH+A V LLL
Sbjct: 537 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLL 595
Query: 230 RAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
GA+P A G TPL A + +A L +GA
Sbjct: 596 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 632
Score = 68.2 bits (165), Expect = 9e-12
Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 17/208 (8%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH++A G+ L AGA +A ++G T LH+A + G+ A+ LLQ R
Sbjct: 509 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA-- 566
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES-EEDWKLQLEAENYEGHTPLH 180
D TP+ + D +K E+ A+N G+TPLH
Sbjct: 567 -----------AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--GYTPLH 613
Query: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240
+A +++ L + GA+ + G +PLHLA + D++ LLL GAN
Sbjct: 614 IAAKKNQMQIASTLLNYGAETNIVTKQ-GVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 672
Query: 241 GGRTPLGSAMLRPNPILARLLRAHGAPE 268
G T L A +A +L HGA +
Sbjct: 673 SGLTSLHLAAQEDKVNVADILTKHGADQ 700
Score = 65.5 bits (158), Expect = 6e-11
Identities = 60/243 (24%), Positives = 98/243 (40%), Gaps = 38/243 (15%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
+D G TALH+A++ G+ V+ L GA + + G T L++A + + L
Sbjct: 69 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128
Query: 115 LQPRPRRPREAPDTY------LAQGPD------------------------RTPDTNHTP 144
L+ + D + L QG + R DT
Sbjct: 129 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 188
Query: 145 VALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKP 204
+ L D + + + K+ + G TPLH+A + +V + LL + GA +D
Sbjct: 189 LLLQNDHNADVQS-------KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 241
Query: 205 EPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAH 264
G +PLH+A + ++++LLL G A+ G TPL A + + LL
Sbjct: 242 ARN-GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 300
Query: 265 GAP 267
GAP
Sbjct: 301 GAP 303
Score = 60.5 bits (145), Expect = 2e-09
Identities = 64/239 (26%), Positives = 95/239 (39%), Gaps = 30/239 (12%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
++ Q+ G T L++AA V+ L GA A G T L +A + G + L
Sbjct: 102 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 161
Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEE-----ESEEDWKLQLE 169
L+ + P ++A D DT + L D + + + + +E +
Sbjct: 162 LENDTKGKVRLPALHIAARKD---DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 218
Query: 170 AENY---------------------EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 208
A +Y G TPLHVA + MV+LL D G +D +
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA-KTRD 277
Query: 209 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
G +PLH A + V+ELLL GA AR G +PL A + + L H AP
Sbjct: 278 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 336
Score = 55.5 bits (132), Expect = 6e-08
Identities = 63/234 (26%), Positives = 88/234 (37%), Gaps = 32/234 (13%)
Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPR 118
N G ALHLAA G V++L G+ + A ++G+TALH+A G + L++
Sbjct: 40 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 99
Query: 119 PRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES--EEDWKLQLEAENYEGH 176
++ + + NH V Y LE +S ED L +GH
Sbjct: 100 ANINAQSQNGFTPL--YMAAQENHIDVVKYL---LENGANQSTATEDGFTPLAVALQQGH 154
Query: 177 T------------------PLHVAVIHKDVEMVRLL--RDAGADLDKP-----EPTCGRS 211
LH+A D + LL D AD+ G +
Sbjct: 155 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 214
Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
PLH+A +V LLL GA G TPL A R N + +LL G
Sbjct: 215 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 268
Score = 53.1 bits (126), Expect = 3e-07
Identities = 63/240 (26%), Positives = 86/240 (35%), Gaps = 48/240 (20%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T +H+AA +G + V L GA V RG TALH+A R G R L
Sbjct: 410 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL------- 462
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
L G ++A E TPLH+
Sbjct: 463 --------LRNGA--------------------------------LVDARAREEQTPLHI 482
Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
A E+V+LL A D T G +PLH++ DV +LL AGA +
Sbjct: 483 ASRLGKTEIVQLLLQHMAHPDAAT-TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK 541
Query: 242 GRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGSP 301
G TPL A + +A+LL A P ++ D+ + E+ SP
Sbjct: 542 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 601
Score = 51.2 bits (121), Expect = 1e-06
Identities = 53/192 (27%), Positives = 77/192 (40%), Gaps = 23/192 (11%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH+AA + L GA + ++G T LHLA + G LL
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667
Query: 122 PREAPD----TYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT 177
+LA D+ N + L K + + KL G+T
Sbjct: 668 HMSTKSGLTSLHLAAQEDKV---NVADI-------LTKHGADQDAHTKL--------GYT 709
Query: 178 PLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAA 237
PL VA + +V+MV L GA+++ G +PLH A + ++ +LL+ GA P A
Sbjct: 710 PLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKPNA 768
Query: 238 RMYGGRTPLGSA 249
G T L A
Sbjct: 769 TTANGNTALAIA 780
Score = 49.7 bits (117), Expect = 3e-06
Identities = 65/245 (26%), Positives = 88/245 (35%), Gaps = 48/245 (19%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGL---------------------CVAER 93
+D + G T LH AA G VE L GA L CV
Sbjct: 271 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 330
Query: 94 RGH------------TALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTN 141
H TALH+A G + + LL R P+
Sbjct: 331 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR-------------ANPNARALNG 377
Query: 142 HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADL 201
TP+ + + K E + + ++A G TP+HVA + +V LL GA
Sbjct: 378 FTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436
Query: 202 DKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLL 261
D G + LH+A A +V+ LLR GA AR +TPL A + +LL
Sbjct: 437 DVTN-IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 495
Query: 262 RAHGA 266
H A
Sbjct: 496 LQHMA 500
Score = 43.1 bits (100), Expect = 3e-04
Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 1/107 (0%)
Query: 172 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231
N G LH+A V +V+ L G+ +D G + LH+A A A+V+++L++
Sbjct: 40 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-GNTALHIASLAGQAEVVKVLVKE 98
Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 278
GAN A+ G TPL A + + + L +GA + ++ P
Sbjct: 99 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 145
Score = 31.6 bits (70), Expect = 0.92
Identities = 20/61 (32%), Positives = 25/61 (40%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
D LG T L +A G V L GA + + G+T LH A + G LL
Sbjct: 701 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 760
Query: 116 Q 116
Q
Sbjct: 761 Q 761
Score = 29.6 bits (65), Expect = 3.5
Identities = 18/45 (40%), Positives = 22/45 (48%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVG 106
G T LH AA G T + L GA G+TAL +A R+G
Sbjct: 740 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 784
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 73.2 bits (178), Expect = 3e-13
Identities = 66/217 (30%), Positives = 93/217 (42%), Gaps = 27/217 (12%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
D+ N G+TALH+AA G+ V L GA + R T LH+A R+G + LL
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517
Query: 116 QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEA----- 170
Q ++A PD +TP+ + E + + LEA
Sbjct: 518 Q------------HMAH-PDAATTNGYTPLHI-------SAREGQVDVASVLLEAGAAHS 557
Query: 171 -ENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLL 229
+G TPLHVA + +++ +LL A D G +PLH+A V LLL
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLL 616
Query: 230 RAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
GA+P A G TPL A + +A L +GA
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653
Score = 68.2 bits (165), Expect = 9e-12
Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 17/208 (8%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH++A G+ L AGA +A ++G T LH+A + G+ A+ LLQ R
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA-- 587
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES-EEDWKLQLEAENYEGHTPLH 180
D TP+ + D +K E+ A+N G+TPLH
Sbjct: 588 -----------AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--GYTPLH 634
Query: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240
+A +++ L + GA+ + G +PLHLA + D++ LLL GAN
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQ-GVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 693
Query: 241 GGRTPLGSAMLRPNPILARLLRAHGAPE 268
G T L A +A +L HGA +
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQ 721
Score = 65.5 bits (158), Expect = 6e-11
Identities = 60/243 (24%), Positives = 98/243 (40%), Gaps = 38/243 (15%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
+D G TALH+A++ G+ V+ L GA + + G T L++A + + L
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 115 LQPRPRRPREAPDTY------LAQGPD------------------------RTPDTNHTP 144
L+ + D + L QG + R DT
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 209
Query: 145 VALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKP 204
+ L D + + + K+ + G TPLH+A + +V + LL + GA +D
Sbjct: 210 LLLQNDHNADVQS-------KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262
Query: 205 EPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAH 264
G +PLH+A + ++++LLL G A+ G TPL A + + LL
Sbjct: 263 ARN-GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321
Query: 265 GAP 267
GAP
Sbjct: 322 GAP 324
Score = 60.5 bits (145), Expect = 2e-09
Identities = 64/239 (26%), Positives = 95/239 (39%), Gaps = 30/239 (12%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
++ Q+ G T L++AA V+ L GA A G T L +A + G + L
Sbjct: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEE-----ESEEDWKLQLE 169
L+ + P ++A D DT + L D + + + + +E +
Sbjct: 183 LENDTKGKVRLPALHIAARKD---DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239
Query: 170 AENY---------------------EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 208
A +Y G TPLHVA + MV+LL D G +D +
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA-KTRD 298
Query: 209 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
G +PLH A + V+ELLL GA AR G +PL A + + L H AP
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357
Score = 55.5 bits (132), Expect = 6e-08
Identities = 63/234 (26%), Positives = 88/234 (37%), Gaps = 32/234 (13%)
Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPR 118
N G ALHLAA G V++L G+ + A ++G+TALH+A G + L++
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
Query: 119 PRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES--EEDWKLQLEAENYEGH 176
++ + + NH V Y LE +S ED L +GH
Sbjct: 121 ANINAQSQNGFTPL--YMAAQENHIDVVKYL---LENGANQSTATEDGFTPLAVALQQGH 175
Query: 177 T------------------PLHVAVIHKDVEMVRLL--RDAGADLDKP-----EPTCGRS 211
LH+A D + LL D AD+ G +
Sbjct: 176 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 235
Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
PLH+A +V LLL GA G TPL A R N + +LL G
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Score = 53.1 bits (126), Expect = 3e-07
Identities = 63/240 (26%), Positives = 86/240 (35%), Gaps = 48/240 (20%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T +H+AA +G + V L GA V RG TALH+A R G R L
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL------- 483
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
L G ++A E TPLH+
Sbjct: 484 --------LRNGA--------------------------------LVDARAREEQTPLHI 503
Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
A E+V+LL A D T G +PLH++ DV +LL AGA +
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAAT-TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK 562
Query: 242 GRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGSP 301
G TPL A + +A+LL A P ++ D+ + E+ SP
Sbjct: 563 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622
Score = 51.2 bits (121), Expect = 1e-06
Identities = 53/192 (27%), Positives = 77/192 (40%), Gaps = 23/192 (11%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH+AA + L GA + ++G T LHLA + G LL
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Query: 122 PREAPD----TYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT 177
+LA D+ N + L K + + KL G+T
Sbjct: 689 HMSTKSGLTSLHLAAQEDKV---NVADI-------LTKHGADQDAHTKL--------GYT 730
Query: 178 PLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAA 237
PL VA + +V+MV L GA+++ G +PLH A + ++ +LL+ GA P A
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 238 RMYGGRTPLGSA 249
G T L A
Sbjct: 790 TTANGNTALAIA 801
Score = 49.7 bits (117), Expect = 3e-06
Identities = 65/245 (26%), Positives = 88/245 (35%), Gaps = 48/245 (19%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGL---------------------CVAER 93
+D + G T LH AA G VE L GA L CV
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351
Query: 94 RGH------------TALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTN 141
H TALH+A G + + LL R P+
Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR-------------ANPNARALNG 398
Query: 142 HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADL 201
TP+ + + K E + + ++A G TP+HVA + +V LL GA
Sbjct: 399 FTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 202 DKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLL 261
D G + LH+A A +V+ LLR GA AR +TPL A + +LL
Sbjct: 458 DVTN-IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Query: 262 RAHGA 266
H A
Sbjct: 517 LQHMA 521
Score = 43.1 bits (100), Expect = 3e-04
Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 1/107 (0%)
Query: 172 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231
N G LH+A V +V+ L G+ +D G + LH+A A A+V+++L++
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-GNTALHIASLAGQAEVVKVLVKE 119
Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 278
GAN A+ G TPL A + + + L +GA + ++ P
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166
Score = 31.6 bits (70), Expect = 0.92
Identities = 20/61 (32%), Positives = 25/61 (40%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
D LG T L +A G V L GA + + G+T LH A + G LL
Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 781
Query: 116 Q 116
Q
Sbjct: 782 Q 782
Score = 29.6 bits (65), Expect = 3.5
Identities = 18/45 (40%), Positives = 22/45 (48%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVG 106
G T LH AA G T + L GA G+TAL +A R+G
Sbjct: 761 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 805
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 73.2 bits (178), Expect = 3e-13
Identities = 66/217 (30%), Positives = 93/217 (42%), Gaps = 27/217 (12%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
D+ N G+TALH+AA G+ V L GA + R T LH+A R+G + LL
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517
Query: 116 QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEA----- 170
Q ++A PD +TP+ + E + + LEA
Sbjct: 518 Q------------HMAH-PDAATTNGYTPLHI-------SAREGQVDVASVLLEAGAAHS 557
Query: 171 -ENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLL 229
+G TPLHVA + +++ +LL A D G +PLH+A V LLL
Sbjct: 558 LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLL 616
Query: 230 RAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
GA+P A G TPL A + +A L +GA
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653
Score = 68.2 bits (165), Expect = 9e-12
Identities = 61/208 (29%), Positives = 91/208 (43%), Gaps = 17/208 (8%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH++A G+ L AGA +A ++G T LH+A + G+ A+ LLQ R
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA-- 587
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES-EEDWKLQLEAENYEGHTPLH 180
D TP+ + D +K E+ A+N G+TPLH
Sbjct: 588 -----------AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN--GYTPLH 634
Query: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240
+A +++ L + GA+ + G +PLHLA + D++ LLL GAN
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQ-GVTPLHLASQEGHTDMVTLLLDKGANIHMSTK 693
Query: 241 GGRTPLGSAMLRPNPILARLLRAHGAPE 268
G T L A +A +L HGA +
Sbjct: 694 SGLTSLHLAAQEDKVNVADILTKHGADQ 721
Score = 65.5 bits (158), Expect = 6e-11
Identities = 60/243 (24%), Positives = 98/243 (40%), Gaps = 38/243 (15%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
+D G TALH+A++ G+ V+ L GA + + G T L++A + + L
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 115 LQPRPRRPREAPDTY------LAQGPD------------------------RTPDTNHTP 144
L+ + D + L QG + R DT
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 209
Query: 145 VALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKP 204
+ L D + + + K+ + G TPLH+A + +V + LL + GA +D
Sbjct: 210 LLLQNDHNADVQS-------KMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT 262
Query: 205 EPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAH 264
G +PLH+A + ++++LLL G A+ G TPL A + + LL
Sbjct: 263 ARN-GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321
Query: 265 GAP 267
GAP
Sbjct: 322 GAP 324
Score = 60.5 bits (145), Expect = 2e-09
Identities = 64/239 (26%), Positives = 95/239 (39%), Gaps = 30/239 (12%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
++ Q+ G T L++AA V+ L GA A G T L +A + G + L
Sbjct: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEE-----ESEEDWKLQLE 169
L+ + P ++A D DT + L D + + + + +E +
Sbjct: 183 LENDTKGKVRLPALHIAARKD---DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239
Query: 170 AENY---------------------EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC 208
A +Y G TPLHVA + MV+LL D G +D +
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA-KTRD 298
Query: 209 GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
G +PLH A + V+ELLL GA AR G +PL A + + L H AP
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357
Score = 55.5 bits (132), Expect = 6e-08
Identities = 63/234 (26%), Positives = 88/234 (37%), Gaps = 32/234 (13%)
Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPR 118
N G ALHLAA G V++L G+ + A ++G+TALH+A G + L++
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
Query: 119 PRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEES--EEDWKLQLEAENYEGH 176
++ + + NH V Y LE +S ED L +GH
Sbjct: 121 ANINAQSQNGFTPL--YMAAQENHIDVVKYL---LENGANQSTATEDGFTPLAVALQQGH 175
Query: 177 T------------------PLHVAVIHKDVEMVRLL--RDAGADLDKP-----EPTCGRS 211
LH+A D + LL D AD+ G +
Sbjct: 176 NQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFT 235
Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
PLH+A +V LLL GA G TPL A R N + +LL G
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Score = 53.1 bits (126), Expect = 3e-07
Identities = 63/240 (26%), Positives = 86/240 (35%), Gaps = 48/240 (20%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T +H+AA +G + V L GA V RG TALH+A R G R L
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL------- 483
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
L G ++A E TPLH+
Sbjct: 484 --------LRNGA--------------------------------LVDARAREEQTPLHI 503
Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
A E+V+LL A D T G +PLH++ DV +LL AGA +
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAAT-TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK 562
Query: 242 GRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEERQGSP 301
G TPL A + +A+LL A P ++ D+ + E+ SP
Sbjct: 563 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622
Score = 51.2 bits (121), Expect = 1e-06
Identities = 53/192 (27%), Positives = 77/192 (40%), Gaps = 23/192 (11%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH+AA + L GA + ++G T LHLA + G LL
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Query: 122 PREAPD----TYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHT 177
+LA D+ N + L K + + KL G+T
Sbjct: 689 HMSTKSGLTSLHLAAQEDKV---NVADI-------LTKHGADQDAHTKL--------GYT 730
Query: 178 PLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAA 237
PL VA + +V+MV L GA+++ G +PLH A + ++ +LL+ GA P A
Sbjct: 731 PLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 238 RMYGGRTPLGSA 249
G T L A
Sbjct: 790 TTANGNTALAIA 801
Score = 49.7 bits (117), Expect = 3e-06
Identities = 65/245 (26%), Positives = 88/245 (35%), Gaps = 48/245 (19%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGL---------------------CVAER 93
+D + G T LH AA G VE L GA L CV
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351
Query: 94 RGH------------TALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTN 141
H TALH+A G + + LL R P+
Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR-------------ANPNARALNG 398
Query: 142 HTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADL 201
TP+ + + K E + + ++A G TP+HVA + +V LL GA
Sbjct: 399 FTPLHIACKKNRIKVMELLVK-YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 202 DKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLL 261
D G + LH+A A +V+ LLR GA AR +TPL A + +LL
Sbjct: 458 DVTN-IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Query: 262 RAHGA 266
H A
Sbjct: 517 LQHMA 521
Score = 43.1 bits (100), Expect = 3e-04
Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 1/107 (0%)
Query: 172 NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRA 231
N G LH+A V +V+ L G+ +D G + LH+A A A+V+++L++
Sbjct: 61 NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK-GNTALHIASLAGQAEVVKVLVKE 119
Query: 232 GANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 278
GAN A+ G TPL A + + + L +GA + ++ P
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166
Score = 31.6 bits (70), Expect = 0.92
Identities = 20/61 (32%), Positives = 25/61 (40%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
D LG T L +A G V L GA + + G+T LH A + G LL
Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 781
Query: 116 Q 116
Q
Sbjct: 782 Q 782
Score = 29.6 bits (65), Expect = 3.5
Identities = 18/45 (40%), Positives = 22/45 (48%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVG 106
G T LH AA G T + L GA G+TAL +A R+G
Sbjct: 761 GYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 805
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 72.0 bits (175), Expect = 6e-13
Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 32/236 (13%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
+D + G T LH+A+ +G V+ L GA V+ + T LH+A R G A+ L
Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
Query: 115 LQPRPRRPREAPDTYLA--------------------QGPDRTPDTNHTPVAL-----YP 149
LQ + + +A D P+ HTP+ + +
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549
Query: 150 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 209
++ L E+E+ + +G TPLHVA + V + LL + A + G
Sbjct: 550 ETVLALLEKEASQ------ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN-G 602
Query: 210 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
+PLH+AV D+++LLL G +P + + G TPL A + +AR L +G
Sbjct: 603 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 658
Score = 61.6 bits (148), Expect = 8e-10
Identities = 59/193 (30%), Positives = 82/193 (42%), Gaps = 25/193 (12%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH+AA + L G +G T LHLA + G HA ALL +
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQAN 693
Query: 122 PREAPDTYLAQGPDRTP-----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176
L TP H PVA L K + ++A G+
Sbjct: 694 GN------LGNKSGLTPLHLVAQEGHVPVA----DVLIKHG--------VMVDATTRMGY 735
Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236
TPLHVA + ++++V+ L AD++ + G SPLH A + D++ LLL+ GA+P
Sbjct: 736 TPLHVASHYGNIKLVKFLLQHQADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794
Query: 237 ARMYGGRTPLGSA 249
G TPL A
Sbjct: 795 EVSSDGTTPLAIA 807
Score = 61.2 bits (147), Expect = 1e-09
Identities = 66/234 (28%), Positives = 92/234 (39%), Gaps = 28/234 (11%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
+L G T LH+AA G TV L A ++G T LH+A + G A LL
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 589
Query: 116 QPRPRRPREAPDTYLAQ--------------------GPDRTPDTN-HTPVALYPDSDLE 154
+ R P A L G +P N +TP+ + + +
Sbjct: 590 E-RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-Q 647
Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSP 212
E S + AE+ +G TPLH+A EMV LL + A +L G +P
Sbjct: 648 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTP 704
Query: 213 LHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
LHL + V ++L++ G A G TPL A N L + L H A
Sbjct: 705 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 758
Score = 60.5 bits (145), Expect = 2e-09
Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 16/221 (7%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G TALH+AA+ G+ V +L GA + ++G T L++A + + LL+ +
Sbjct: 111 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 170
Query: 122 PREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAE 171
D + L QG + + P + +++ L
Sbjct: 171 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 230
Query: 172 NYE-----GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 226
N + G TPLH+A ++++ + +LL + GA ++ P G +PLH+A ++
Sbjct: 231 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVR 289
Query: 227 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
LLL GA + TPL A + ++ +L HGAP
Sbjct: 290 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 330
Score = 58.5 bits (140), Expect = 7e-09
Identities = 65/225 (28%), Positives = 87/225 (38%), Gaps = 24/225 (10%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH+A +E L GA + G T LH+A +G + LLQ R
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGAS 462
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW---------------KL 166
P + + HT VA Y + K ++++D KL
Sbjct: 463 P-NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 521
Query: 167 QLE------AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ 220
LE GHTPLH+A VE V L + A G +PLH+A +
Sbjct: 522 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYG 580
Query: 221 AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
V ELLL A+P A G TPL A+ N + +LL G
Sbjct: 581 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625
Score = 55.8 bits (133), Expect = 5e-08
Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 29/238 (12%)
Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115
N G LHLA+ G V +L L ++G+TALH+A G R L+
Sbjct: 75 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134
Query: 116 -QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-----KLQLE 169
+ + Y+A NH V + + + +E+ + LQ
Sbjct: 135 ANVNAQSQKGFTPLYMA------AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 188
Query: 170 AENYEGH------------TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAV 217
EN H LH+A + D +L + D T G +PLH+A
Sbjct: 189 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAA 247
Query: 218 EAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDE 274
+ +V +LLL GA+ G TPL A R N I+ RLL GA E + +DE
Sbjct: 248 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 305
Score = 55.5 bits (132), Expect = 6e-08
Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 25/234 (10%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
D+ + G T LH+AA + + L GA + + G T LH+A R G R LL
Sbjct: 233 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 292
Query: 116 ----QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED--- 163
Q + E + A G R + + P+ + L ++ D
Sbjct: 293 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 352
Query: 164 ---WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLH 214
LQ +AE + TPLHVA + ++L D GA KP G +PLH
Sbjct: 353 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLH 409
Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 267
+A + V+ELLL+ GA+ A G TPL A + PI+ LL+ +P
Sbjct: 410 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463
Score = 38.1 bits (87), Expect = 0.010
Identities = 56/235 (23%), Positives = 85/235 (36%), Gaps = 46/235 (19%)
Query: 64 TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPR 123
T LH AA G E L GA + + G + +H+A + C R LLQ
Sbjct: 307 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ------- 359
Query: 124 EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAV 183
Y A+ D T D + TP+ + + + D + + G TPLH+A
Sbjct: 360 -----YDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIAC 412
Query: 184 IHKDVEMVRLLRDAGADLDK----------------------------PEPTCGR----S 211
V ++ LL GA +D P +
Sbjct: 413 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 472
Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
PLH+A A +V + LL+ A A+ +TPL A + + +LL + A
Sbjct: 473 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 527
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 72.0 bits (175), Expect = 6e-13
Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 32/236 (13%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
+D + G T LH+A+ +G V+ L GA V+ + T LH+A R G A+ L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 115 LQPRPRRPREAPDTYLA--------------------QGPDRTPDTNHTPVAL-----YP 149
LQ + + +A D P+ HTP+ + +
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 150 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 209
++ L E+E+ + +G TPLHVA + V + LL + A + G
Sbjct: 517 ETVLALLEKEASQ------ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN-G 569
Query: 210 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
+PLH+AV D+++LLL G +P + + G TPL A + +AR L +G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625
Score = 61.6 bits (148), Expect = 8e-10
Identities = 59/193 (30%), Positives = 82/193 (42%), Gaps = 25/193 (12%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH+AA + L G +G T LHLA + G HA ALL +
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQAN 660
Query: 122 PREAPDTYLAQGPDRTP-----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176
L TP H PVA L K + ++A G+
Sbjct: 661 GN------LGNKSGLTPLHLVAQEGHVPVA----DVLIKHG--------VMVDATTRMGY 702
Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236
TPLHVA + ++++V+ L AD++ + G SPLH A + D++ LLL+ GA+P
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 237 ARMYGGRTPLGSA 249
G TPL A
Sbjct: 762 EVSSDGTTPLAIA 774
Score = 61.2 bits (147), Expect = 1e-09
Identities = 66/234 (28%), Positives = 92/234 (39%), Gaps = 28/234 (11%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
+L G T LH+AA G TV L A ++G T LH+A + G A LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 116 QPRPRRPREAPDTYLAQ--------------------GPDRTPDTN-HTPVALYPDSDLE 154
+ R P A L G +P N +TP+ + + +
Sbjct: 557 E-RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-Q 614
Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSP 212
E S + AE+ +G TPLH+A EMV LL + A +L G +P
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTP 671
Query: 213 LHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
LHL + V ++L++ G A G TPL A N L + L H A
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Score = 60.5 bits (145), Expect = 2e-09
Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 16/221 (7%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G TALH+AA+ G+ V +L GA + ++G T L++A + + LL+ +
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 122 PREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAE 171
D + L QG + + P + +++ L
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 172 NYE-----GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 226
N + G TPLH+A ++++ + +LL + GA ++ P G +PLH+A ++
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVR 256
Query: 227 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
LLL GA + TPL A + ++ +L HGAP
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 58.5 bits (140), Expect = 7e-09
Identities = 65/225 (28%), Positives = 87/225 (38%), Gaps = 24/225 (10%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH+A +E L GA + G T LH+A +G + LLQ R
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGAS 429
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW---------------KL 166
P + + HT VA Y + K ++++D KL
Sbjct: 430 P-NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488
Query: 167 QLE------AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ 220
LE GHTPLH+A VE V L + A G +PLH+A +
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYG 547
Query: 221 AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
V ELLL A+P A G TPL A+ N + +LL G
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 55.8 bits (133), Expect = 5e-08
Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 29/238 (12%)
Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115
N G LHLA+ G V +L L ++G+TALH+A G R L+
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 116 -QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-----KLQLE 169
+ + Y+A NH V + + + +E+ + LQ
Sbjct: 102 ANVNAQSQKGFTPLYMA------AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 170 AENYEGH------------TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAV 217
EN H LH+A + D +L + D T G +PLH+A
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAA 214
Query: 218 EAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDE 274
+ +V +LLL GA+ G TPL A R N I+ RLL GA E + +DE
Sbjct: 215 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Score = 55.5 bits (132), Expect = 6e-08
Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 25/234 (10%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
D+ + G T LH+AA + + L GA + + G T LH+A R G R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 116 ----QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED--- 163
Q + E + A G R + + P+ + L ++ D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 164 ---WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLH 214
LQ +AE + TPLHVA + ++L D GA KP G +PLH
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLH 376
Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 267
+A + V+ELLL+ GA+ A G TPL A + PI+ LL+ +P
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Score = 38.1 bits (87), Expect = 0.010
Identities = 56/235 (23%), Positives = 85/235 (36%), Gaps = 46/235 (19%)
Query: 64 TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPR 123
T LH AA G E L GA + + G + +H+A + C R LLQ
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ------- 326
Query: 124 EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAV 183
Y A+ D T D + TP+ + + + D + + G TPLH+A
Sbjct: 327 -----YDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIAC 379
Query: 184 IHKDVEMVRLLRDAGADLDK----------------------------PEPTCGR----S 211
V ++ LL GA +D P +
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
PLH+A A +V + LL+ A A+ +TPL A + + +LL + A
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 72.0 bits (175), Expect = 6e-13
Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 32/236 (13%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
+D + G T LH+A+ +G V+ L GA V+ + T LH+A R G A+ L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 115 LQPRPRRPREAPDTYLA--------------------QGPDRTPDTNHTPVAL-----YP 149
LQ + + +A D P+ HTP+ + +
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 150 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 209
++ L E+E+ + +G TPLHVA + V + LL + A + G
Sbjct: 517 ETVLALLEKEASQ------ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN-G 569
Query: 210 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
+PLH+AV D+++LLL G +P + + G TPL A + +AR L +G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625
Score = 61.6 bits (148), Expect = 8e-10
Identities = 59/193 (30%), Positives = 82/193 (42%), Gaps = 25/193 (12%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH+AA + L G +G T LHLA + G HA ALL +
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQAN 660
Query: 122 PREAPDTYLAQGPDRTP-----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176
L TP H PVA L K + ++A G+
Sbjct: 661 GN------LGNKSGLTPLHLVAQEGHVPVA----DVLIKHG--------VMVDATTRMGY 702
Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236
TPLHVA + ++++V+ L AD++ + G SPLH A + D++ LLL+ GA+P
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 237 ARMYGGRTPLGSA 249
G TPL A
Sbjct: 762 EVSSDGTTPLAIA 774
Score = 61.2 bits (147), Expect = 1e-09
Identities = 66/234 (28%), Positives = 92/234 (39%), Gaps = 28/234 (11%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
+L G T LH+AA G TV L A ++G T LH+A + G A LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 116 QPRPRRPREAPDTYLAQ--------------------GPDRTPDTN-HTPVALYPDSDLE 154
+ R P A L G +P N +TP+ + + +
Sbjct: 557 E-RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-Q 614
Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSP 212
E S + AE+ +G TPLH+A EMV LL + A +L G +P
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTP 671
Query: 213 LHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
LHL + V ++L++ G A G TPL A N L + L H A
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Score = 60.5 bits (145), Expect = 2e-09
Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 16/221 (7%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G TALH+AA+ G+ V +L GA + ++G T L++A + + LL+ +
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 122 PREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAE 171
D + L QG + + P + +++ L
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 172 NYE-----GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 226
N + G TPLH+A ++++ + +LL + GA ++ P G +PLH+A ++
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVR 256
Query: 227 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
LLL GA + TPL A + ++ +L HGAP
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 58.5 bits (140), Expect = 7e-09
Identities = 65/225 (28%), Positives = 87/225 (38%), Gaps = 24/225 (10%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH+A +E L GA + G T LH+A +G + LLQ R
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGAS 429
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW---------------KL 166
P + + HT VA Y + K ++++D KL
Sbjct: 430 P-NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488
Query: 167 QLE------AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ 220
LE GHTPLH+A VE V L + A G +PLH+A +
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYG 547
Query: 221 AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
V ELLL A+P A G TPL A+ N + +LL G
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 55.8 bits (133), Expect = 5e-08
Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 29/238 (12%)
Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115
N G LHLA+ G V +L L ++G+TALH+A G R L+
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 116 -QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-----KLQLE 169
+ + Y+A NH V + + + +E+ + LQ
Sbjct: 102 ANVNAQSQKGFTPLYMA------AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 170 AENYEGH------------TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAV 217
EN H LH+A + D +L + D T G +PLH+A
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAA 214
Query: 218 EAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDE 274
+ +V +LLL GA+ G TPL A R N I+ RLL GA E + +DE
Sbjct: 215 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Score = 55.5 bits (132), Expect = 6e-08
Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 25/234 (10%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
D+ + G T LH+AA + + L GA + + G T LH+A R G R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 116 ----QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED--- 163
Q + E + A G R + + P+ + L ++ D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 164 ---WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLH 214
LQ +AE + TPLHVA + ++L D GA KP G +PLH
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLH 376
Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 267
+A + V+ELLL+ GA+ A G TPL A + PI+ LL+ +P
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Score = 38.1 bits (87), Expect = 0.010
Identities = 56/235 (23%), Positives = 85/235 (36%), Gaps = 46/235 (19%)
Query: 64 TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPR 123
T LH AA G E L GA + + G + +H+A + C R LLQ
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ------- 326
Query: 124 EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAV 183
Y A+ D T D + TP+ + + + D + + G TPLH+A
Sbjct: 327 -----YDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIAC 379
Query: 184 IHKDVEMVRLLRDAGADLDK----------------------------PEPTCGR----S 211
V ++ LL GA +D P +
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
PLH+A A +V + LL+ A A+ +TPL A + + +LL + A
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 72.0 bits (175), Expect = 6e-13
Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 32/236 (13%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
+D + G T LH+A+ +G V+ L GA V+ + T LH+A R G A+ L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 115 LQPRPRRPREAPDTYLA--------------------QGPDRTPDTNHTPVAL-----YP 149
LQ + + +A D P+ HTP+ + +
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 150 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 209
++ L E+E+ + +G TPLHVA + V + LL + A + G
Sbjct: 517 ETVLALLEKEASQ------ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN-G 569
Query: 210 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
+PLH+AV D+++LLL G +P + + G TPL A + +AR L +G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625
Score = 61.6 bits (148), Expect = 8e-10
Identities = 59/193 (30%), Positives = 82/193 (42%), Gaps = 25/193 (12%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH+AA + L G +G T LHLA + G HA ALL +
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQAN 660
Query: 122 PREAPDTYLAQGPDRTP-----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176
L TP H PVA L K + ++A G+
Sbjct: 661 GN------LGNKSGLTPLHLVAQEGHVPVA----DVLIKHG--------VMVDATTRMGY 702
Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236
TPLHVA + ++++V+ L AD++ + G SPLH A + D++ LLL+ GA+P
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 237 ARMYGGRTPLGSA 249
G TPL A
Sbjct: 762 EVSSDGTTPLAIA 774
Score = 61.2 bits (147), Expect = 1e-09
Identities = 66/234 (28%), Positives = 92/234 (39%), Gaps = 28/234 (11%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
+L G T LH+AA G TV L A ++G T LH+A + G A LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 116 QPRPRRPREAPDTYLAQ--------------------GPDRTPDTN-HTPVALYPDSDLE 154
+ R P A L G +P N +TP+ + + +
Sbjct: 557 E-RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-Q 614
Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSP 212
E S + AE+ +G TPLH+A EMV LL + A +L G +P
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTP 671
Query: 213 LHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
LHL + V ++L++ G A G TPL A N L + L H A
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Score = 60.5 bits (145), Expect = 2e-09
Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 16/221 (7%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G TALH+AA+ G+ V +L GA + ++G T L++A + + LL+ +
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 122 PREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAE 171
D + L QG + + P + +++ L
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 172 NYE-----GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 226
N + G TPLH+A ++++ + +LL + GA ++ P G +PLH+A ++
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVR 256
Query: 227 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
LLL GA + TPL A + ++ +L HGAP
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 58.5 bits (140), Expect = 7e-09
Identities = 65/225 (28%), Positives = 87/225 (38%), Gaps = 24/225 (10%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH+A +E L GA + G T LH+A +G + LLQ R
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGAS 429
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW---------------KL 166
P + + HT VA Y + K ++++D KL
Sbjct: 430 P-NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488
Query: 167 QLE------AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ 220
LE GHTPLH+A VE V L + A G +PLH+A +
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYG 547
Query: 221 AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
V ELLL A+P A G TPL A+ N + +LL G
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 55.8 bits (133), Expect = 5e-08
Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 29/238 (12%)
Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115
N G LHLA+ G V +L L ++G+TALH+A G R L+
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 116 -QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-----KLQLE 169
+ + Y+A NH V + + + +E+ + LQ
Sbjct: 102 ANVNAQSQKGFTPLYMA------AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 170 AENYEGH------------TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAV 217
EN H LH+A + D +L + D T G +PLH+A
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAA 214
Query: 218 EAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDE 274
+ +V +LLL GA+ G TPL A R N I+ RLL GA E + +DE
Sbjct: 215 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Score = 55.5 bits (132), Expect = 6e-08
Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 25/234 (10%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
D+ + G T LH+AA + + L GA + + G T LH+A R G R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 116 ----QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED--- 163
Q + E + A G R + + P+ + L ++ D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 164 ---WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLH 214
LQ +AE + TPLHVA + ++L D GA KP G +PLH
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLH 376
Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 267
+A + V+ELLL+ GA+ A G TPL A + PI+ LL+ +P
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Score = 38.1 bits (87), Expect = 0.010
Identities = 56/235 (23%), Positives = 85/235 (36%), Gaps = 46/235 (19%)
Query: 64 TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPR 123
T LH AA G E L GA + + G + +H+A + C R LLQ
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ------- 326
Query: 124 EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAV 183
Y A+ D T D + TP+ + + + D + + G TPLH+A
Sbjct: 327 -----YDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIAC 379
Query: 184 IHKDVEMVRLLRDAGADLDK----------------------------PEPTCGR----S 211
V ++ LL GA +D P +
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
PLH+A A +V + LL+ A A+ +TPL A + + +LL + A
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 72.0 bits (175), Expect = 6e-13
Identities = 63/236 (26%), Positives = 101/236 (42%), Gaps = 32/236 (13%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
+D + G T LH+A+ +G V+ L GA V+ + T LH+A R G A+ L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 115 LQPRPRRPREAPDTYLA--------------------QGPDRTPDTNHTPVAL-----YP 149
LQ + + +A D P+ HTP+ + +
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516
Query: 150 DSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCG 209
++ L E+E+ + +G TPLHVA + V + LL + A + G
Sbjct: 517 ETVLALLEKEASQ------ACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN-G 569
Query: 210 RSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
+PLH+AV D+++LLL G +P + + G TPL A + +AR L +G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG 625
Score = 61.6 bits (148), Expect = 8e-10
Identities = 59/193 (30%), Positives = 82/193 (42%), Gaps = 25/193 (12%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH+AA + L G +G T LHLA + G HA ALL +
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEG-HAEMVALLLSKQAN 660
Query: 122 PREAPDTYLAQGPDRTP-----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176
L TP H PVA L K + ++A G+
Sbjct: 661 GN------LGNKSGLTPLHLVAQEGHVPVA----DVLIKHG--------VMVDATTRMGY 702
Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236
TPLHVA + ++++V+ L AD++ + G SPLH A + D++ LLL+ GA+P
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNA-KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 237 ARMYGGRTPLGSA 249
G TPL A
Sbjct: 762 EVSSDGTTPLAIA 774
Score = 61.2 bits (147), Expect = 1e-09
Identities = 66/234 (28%), Positives = 92/234 (39%), Gaps = 28/234 (11%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
+L G T LH+AA G TV L A ++G T LH+A + G A LL
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 116 QPRPRRPREAPDTYLAQ--------------------GPDRTPDTN-HTPVALYPDSDLE 154
+ R P A L G +P N +TP+ + + +
Sbjct: 557 E-RDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN-Q 614
Query: 155 KEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLL--RDAGADLDKPEPTCGRSP 212
E S + AE+ +G TPLH+A EMV LL + A +L G +P
Sbjct: 615 VEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTP 671
Query: 213 LHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
LHL + V ++L++ G A G TPL A N L + L H A
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Score = 60.5 bits (145), Expect = 2e-09
Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 16/221 (7%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G TALH+AA+ G+ V +L GA + ++G T L++A + + LL+ +
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 122 PREAPDTY------LAQGPDRTP----DTNHTPVALYPDSDLEKEEEESEEDWKLQLEAE 171
D + L QG + + P + +++ L
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 172 NYE-----GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE 226
N + G TPLH+A ++++ + +LL + GA ++ P G +PLH+A ++
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVR 256
Query: 227 LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
LLL GA + TPL A + ++ +L HGAP
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 58.5 bits (140), Expect = 7e-09
Identities = 65/225 (28%), Positives = 87/225 (38%), Gaps = 24/225 (10%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G T LH+A +E L GA + G T LH+A +G + LLQ R
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ-RGAS 429
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW---------------KL 166
P + + HT VA Y + K ++++D KL
Sbjct: 430 P-NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488
Query: 167 QLE------AENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ 220
LE GHTPLH+A VE V L + A G +PLH+A +
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYG 547
Query: 221 AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHG 265
V ELLL A+P A G TPL A+ N + +LL G
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 55.8 bits (133), Expect = 5e-08
Identities = 64/238 (26%), Positives = 93/238 (39%), Gaps = 29/238 (12%)
Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115
N G LHLA+ G V +L L ++G+TALH+A G R L+
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 116 -QPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDW-----KLQLE 169
+ + Y+A NH V + + + +E+ + LQ
Sbjct: 102 ANVNAQSQKGFTPLYMA------AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 170 AENYEGH------------TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAV 217
EN H LH+A + D +L + D T G +PLH+A
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAA 214
Query: 218 EAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP-EPEGEDE 274
+ +V +LLL GA+ G TPL A R N I+ RLL GA E + +DE
Sbjct: 215 HYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Score = 55.5 bits (132), Expect = 6e-08
Identities = 67/234 (28%), Positives = 98/234 (41%), Gaps = 25/234 (10%)
Query: 56 DLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
D+ + G T LH+AA + + L GA + + G T LH+A R G R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 116 ----QPRPRRPREAPDTYLA--QGPDRTPD---TNHTPVALYPDSDLEKEEEESEED--- 163
Q + E + A G R + + P+ + L ++ D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 164 ---WKLQLEAE----NYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTC--GRSPLH 214
LQ +AE + TPLHVA + ++L D GA KP G +PLH
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA---KPNSRALNGFTPLH 376
Query: 215 LAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAP 267
+A + V+ELLL+ GA+ A G TPL A + PI+ LL+ +P
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Score = 38.1 bits (87), Expect = 0.010
Identities = 56/235 (23%), Positives = 85/235 (36%), Gaps = 46/235 (19%)
Query: 64 TALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPR 123
T LH AA G E L GA + + G + +H+A + C R LLQ
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ------- 326
Query: 124 EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAV 183
Y A+ D T D + TP+ + + + D + + G TPLH+A
Sbjct: 327 -----YDAEIDDITLD-HLTPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIAC 379
Query: 184 IHKDVEMVRLLRDAGADLDK----------------------------PEPTCGR----S 211
V ++ LL GA +D P +
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439
Query: 212 PLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
PLH+A A +V + LL+ A A+ +TPL A + + +LL + A
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA 494
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 70.9 bits (172), Expect = 1e-12
Identities = 75/229 (32%), Positives = 97/229 (42%), Gaps = 42/229 (18%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G+TALH A G T+ V L AGA +A++ G LHL G CA LL+
Sbjct: 193 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR----- 247
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQL----EAENYEGHT 177
+ A+ R+ + TP L+ + L E D L+ +A N EG T
Sbjct: 248 -------FGARVDGRSEEEEETP--LHVAARLGHVE---LADLLLRRGACPDARNAEGWT 295
Query: 178 PLHV-------------AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADV 224
PL A + +++ LL AGAD D + R PLHLA A V
Sbjct: 296 PLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR-PLHLACRRGHAAV 354
Query: 225 LELLLRAGANPAARMYGGRTPLGSAMLRPNPILA-------RLLRAHGA 266
+ELLL G + YGG TPL A+ P LA R L HGA
Sbjct: 355 VELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
Score = 43.9 bits (102), Expect = 2e-04
Identities = 46/138 (33%), Positives = 60/138 (43%), Gaps = 14/138 (10%)
Query: 147 LYPDSDLEKEEEESEEDWK-----LQLEAENYEGH--TPLHVAVIHKDVEMVRLLRDAGA 199
L PDS + + E D++ L+L + YE TPLHVA E++RLL A
Sbjct: 126 LAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRA 185
Query: 200 DLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL----GSAMLRPNP 255
D GR+ LH A A + +LL AGA+P G+ PL G L
Sbjct: 186 RPDSAPG--GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAE 243
Query: 256 ILARL-LRAHGAPEPEGE 272
+L R R G E E E
Sbjct: 244 LLLRFGARVDGRSEEEEE 261
>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
[Homo sapiens]
Length = 512
Score = 70.9 bits (172), Expect = 1e-12
Identities = 75/229 (32%), Positives = 97/229 (42%), Gaps = 42/229 (18%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G+TALH A G T+ V L AGA +A++ G LHL G CA LL+
Sbjct: 193 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR----- 247
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQL----EAENYEGHT 177
+ A+ R+ + TP L+ + L E D L+ +A N EG T
Sbjct: 248 -------FGARVDGRSEEEEETP--LHVAARLGHVE---LADLLLRRGACPDARNAEGWT 295
Query: 178 PLHV-------------AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADV 224
PL A + +++ LL AGAD D + R PLHLA A V
Sbjct: 296 PLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR-PLHLACRRGHAAV 354
Query: 225 LELLLRAGANPAARMYGGRTPLGSAMLRPNPILA-------RLLRAHGA 266
+ELLL G + YGG TPL A+ P LA R L HGA
Sbjct: 355 VELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 403
Score = 43.9 bits (102), Expect = 2e-04
Identities = 46/138 (33%), Positives = 60/138 (43%), Gaps = 14/138 (10%)
Query: 147 LYPDSDLEKEEEESEEDWK-----LQLEAENYEGH--TPLHVAVIHKDVEMVRLLRDAGA 199
L PDS + + E D++ L+L + YE TPLHVA E++RLL A
Sbjct: 126 LAPDSVFDTSDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRA 185
Query: 200 DLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL----GSAMLRPNP 255
D GR+ LH A A + +LL AGA+P G+ PL G L
Sbjct: 186 RPDSAPG--GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAE 243
Query: 256 ILARL-LRAHGAPEPEGE 272
+L R R G E E E
Sbjct: 244 LLLRFGARVDGRSEEEEE 261
>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
[Homo sapiens]
Length = 452
Score = 70.9 bits (172), Expect = 1e-12
Identities = 75/229 (32%), Positives = 97/229 (42%), Gaps = 42/229 (18%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G+TALH A G T+ V L AGA +A++ G LHL G CA LL+
Sbjct: 133 GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR----- 187
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQL----EAENYEGHT 177
+ A+ R+ + TP L+ + L E D L+ +A N EG T
Sbjct: 188 -------FGARVDGRSEEEEETP--LHVAARLGHVE---LADLLLRRGACPDARNAEGWT 235
Query: 178 PLHV-------------AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADV 224
PL A + +++ LL AGAD D + R PLHLA A V
Sbjct: 236 PLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQR-PLHLACRRGHAAV 294
Query: 225 LELLLRAGANPAARMYGGRTPLGSAMLRPNPILA-------RLLRAHGA 266
+ELLL G + YGG TPL A+ P LA R L HGA
Sbjct: 295 VELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA 343
Score = 45.8 bits (107), Expect = 5e-05
Identities = 61/194 (31%), Positives = 73/194 (37%), Gaps = 19/194 (9%)
Query: 96 HTALHLACRVGAHACA--RALLQPRPRRPREAP---DTYLAQGPDRTPDTNHTPVALYPD 150
H HL C A AC R +P PR +P Q T D P
Sbjct: 10 HWGHHLGCLPSAPACRIWRPHSRPAWEPPRPSPLLCQDMALQNALYTGDLARLQELFPPH 69
Query: 151 S--DLEKEEEESEEDWKLQ---LEAENYEGH--TPLHVAVIHKDVEMVRLLRDAGADLDK 203
S DL E +E W L + YE TPLHVA E++RLL A D
Sbjct: 70 STADLLLESRAAEPRWSSHQRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDS 129
Query: 204 PEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL----GSAMLRPNPILAR 259
GR+ LH A A + +LL AGA+P G+ PL G L +L R
Sbjct: 130 APG--GRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR 187
Query: 260 L-LRAHGAPEPEGE 272
R G E E E
Sbjct: 188 FGARVDGRSEEEEE 201
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 70.5 bits (171), Expect = 2e-12
Identities = 62/205 (30%), Positives = 81/205 (39%), Gaps = 48/205 (23%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G LH AA G+ T L GA + ER G T LHLA + AR L+
Sbjct: 428 GWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV------ 481
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
R D N EG TPLHV
Sbjct: 482 -------------SRQADPN----------------------------LHEAEGKTPLHV 500
Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
A V +V+LL GA+LD + R+PLHLAVE ++ LL++GA P A
Sbjct: 501 AAYFGHVSLVKLLTSQGAELDAQQRNL-RTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559
Query: 242 GRTPLGSAMLRPNPILARLLRAHGA 266
G PL +A R ++ ++L +GA
Sbjct: 560 GYGPLHTAAARGKYLICKMLLRYGA 584
Score = 61.2 bits (147), Expect = 1e-09
Identities = 57/192 (29%), Positives = 85/192 (44%), Gaps = 17/192 (8%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G+T LH+AA G S V+ L + GA L +R T LHLA G + LL+
Sbjct: 494 GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS---- 549
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEE-ESEEDWKLQLEAENYEGHTPLH 180
PD + + P L+ + K + + LE ++G TPLH
Sbjct: 550 ---------GAVPDALDQSGYGP--LHTAAARGKYLICKMLLRYGASLELPTHQGWTPLH 598
Query: 181 VAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMY 240
+A +E++ LL ++ A++ +PLHLA V+ LL+ GA+P A
Sbjct: 599 LAAYKGHLEIIHLLAESHANMGALGAV-NWTPLHLAARHGEEAVVSALLQCGADPNAAEQ 657
Query: 241 GGRTPLGSAMLR 252
G TPL A+ R
Sbjct: 658 SGWTPLHLAVQR 669
Score = 56.2 bits (134), Expect = 3e-08
Identities = 51/191 (26%), Positives = 76/191 (39%), Gaps = 17/191 (8%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
++L G T LHLAA G + L + A + T LHLA R G A AL
Sbjct: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 174
LQ P+ + TP+ L E + A N
Sbjct: 646 LQ-------------CGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEH-HANVHARNKV 691
Query: 175 GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
G TP H+A + + ++++L +AGA LD + +PL LA+ ++ ++ L G
Sbjct: 692 GWTPAHLAALKGNTAILKVLVEAGAQLDVQDGV-SCTPLQLALRSRKQGIMSFL--EGKE 748
Query: 235 PAARMYGGRTP 245
P+ GG P
Sbjct: 749 PSVATLGGSKP 759
Score = 55.5 bits (132), Expect = 6e-08
Identities = 67/219 (30%), Positives = 94/219 (42%), Gaps = 18/219 (8%)
Query: 49 SAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAH 108
S G E +D Q +T LHLA G+ ++ L +GA ++ G+ LH A G +
Sbjct: 515 SQGAE-LDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573
Query: 109 ACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKL-Q 167
+ LL R L TP +A Y LE +E +
Sbjct: 574 LICKMLL-------RYGASLELPTHQGWTP----LHLAAY-KGHLEIIHLLAESHANMGA 621
Query: 168 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL 227
L A N+ TPLH+A H + +V L GAD + E + G +PLHLAV+ +
Sbjct: 622 LGAVNW---TPLHLAARHGEEAVVSALLQCGADPNAAEQS-GWTPLHLAVQRSTFLSVIN 677
Query: 228 LLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
LL AN AR G TP A L+ N + ++L GA
Sbjct: 678 LLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA 716
Score = 50.4 bits (119), Expect = 2e-06
Identities = 35/93 (37%), Positives = 47/93 (50%), Gaps = 1/93 (1%)
Query: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233
+G PLH A + D RLL D GA +D E G +PLHLA + +V LL+ A
Sbjct: 427 DGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENVARLLVSRQA 485
Query: 234 NPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
+P G+TPL A + L +LL + GA
Sbjct: 486 DPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGA 518
Score = 47.0 bits (110), Expect = 2e-05
Identities = 41/125 (32%), Positives = 54/125 (43%), Gaps = 1/125 (0%)
Query: 177 TPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPA 236
TPLH V VE VRLL D+D + G +PL +A + Q D+ LLL GA+
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDC-QTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 237 ARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGVSQEE 296
G PL A + ARLL HGA E E P ++ ++ +
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482
Query: 297 RQGSP 301
RQ P
Sbjct: 483 RQADP 487
Score = 44.7 bits (104), Expect = 1e-04
Identities = 33/102 (32%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 168 LEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLEL 227
++A+ EG TPLH+A + + RLL AD + E G++PLH+A +++L
Sbjct: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAE-GKTPLHVAAYFGHVSLVKL 512
Query: 228 LLRAGANPAARMYGGRTPLGSAMLRPN-PILARLLRAHGAPE 268
L GA A+ RTPL A+ R + LL++ P+
Sbjct: 513 LTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPD 554
Score = 40.0 bits (92), Expect = 0.003
Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 1/114 (0%)
Query: 165 KLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADV 224
++ ++ + G+TPL +A + ++ LL GAD ++ + G +PLH A +
Sbjct: 385 EVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDED-GWAPLHFAAQNGDDGT 443
Query: 225 LELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 278
LLL GA A+ G TPL A +ARLL + A E E P
Sbjct: 444 ARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTP 497
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 70.5 bits (171), Expect = 2e-12
Identities = 76/263 (28%), Positives = 111/263 (42%), Gaps = 35/263 (13%)
Query: 31 CRGLPSSS-----ATSLRMGTRFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAG 85
CR L SS +SL SAG + ++ ++LG+T LH AA G + L ++G
Sbjct: 388 CRKLLSSGQLYSIVSSLSNEHVLSAGFD-INTPDNLGRTCLHAAASGGNVECLNLLLSSG 446
Query: 86 AGLCVAERRGHTALHLACRVGAHACARALLQP------------RPRRPREAPDTYLAQG 133
A L ++ G T LH A G++ CA L+ P A DTY
Sbjct: 447 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE 506
Query: 134 PDRTPDTNHTPVALYPDSDLE-KEEEESEEDWKLQLEAEN--------YEGHTPLHVAVI 184
P HTP + + D KE E + L+ +N +G+T +H A
Sbjct: 507 P-------HTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAA 559
Query: 185 HKDVEMVRLLRDAGAD-LDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGR 243
+ + + + LL + + L+ E T SPLHLA + L+ L N R + GR
Sbjct: 560 YGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGR 619
Query: 244 TPLGSAMLRPNPILARLLRAHGA 266
T L A R + +L AHGA
Sbjct: 620 TALFLATERGSTECVEVLTAHGA 642
Score = 57.4 bits (137), Expect = 2e-08
Identities = 70/248 (28%), Positives = 93/248 (37%), Gaps = 23/248 (9%)
Query: 25 RSWARGCRGLPSSSATSLRMGTRFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAA 84
R W S SL + + D+ + GQT L LA + G V L
Sbjct: 651 RKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710
Query: 85 GAGLCVAERRGHTALHLACRVGAHACARALLQPRP----RRPREAPDTYLAQGPDRTPDT 140
G+ A+ RG TALH G C ALL R + +LA T
Sbjct: 711 GSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVL 770
Query: 141 NHTPVALYPDSDLEKEEEES-------------EEDWKLQLEAENY---EGH--TPLHVA 182
A L+ + S E+ +L LE + EG+ TPLH A
Sbjct: 771 RTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCA 830
Query: 183 VI-HKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
VI ++D LL GA + GR+PLH A A L +LL+ A A +
Sbjct: 831 VINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT 890
Query: 242 GRTPLGSA 249
GRT L +A
Sbjct: 891 GRTALMTA 898
Score = 55.5 bits (132), Expect = 6e-08
Identities = 51/190 (26%), Positives = 81/190 (42%), Gaps = 14/190 (7%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G LH AA G+ V+ L GA + G+TALH+AC +G A A L+
Sbjct: 206 GYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVN----- 260
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
++ D TP+ + S E + + ++ EG +PLH+
Sbjct: 261 --------AGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHM 312
Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
A IH ++L G+++D + G +PLH+A ++ L+ GA+ A R
Sbjct: 313 AAIHGRFTRSQILIQNGSEIDCAD-KFGNTPLHVAARYGHELLISTLMTNGADTARRGIH 371
Query: 242 GRTPLGSAML 251
PL A+L
Sbjct: 372 DMFPLHLAVL 381
Score = 48.9 bits (115), Expect = 6e-06
Identities = 64/236 (27%), Positives = 106/236 (44%), Gaps = 29/236 (12%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
++ ++ L QT LH+AA T E L + L VA+R G +ALH A G L
Sbjct: 100 VNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLL 159
Query: 115 LQP---------RPRRPR---------EAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKE 156
L + R+P E +A+G D L+ + +
Sbjct: 160 LNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQI 219
Query: 157 EEESEEDWKLQLEAE----NYEGHTPLHVAV-IHKDVEMVRLLRDAGADLDKPEPTCGRS 211
E + L++ AE N G+T LH+A + +D + L+ +AGA++++P G +
Sbjct: 220 EVVK---YLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV-NAGANVNQPNDK-GFT 274
Query: 212 PLHLA-VEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
PLH+A V A LELL+ GA+ + G++PL A + +++L +G+
Sbjct: 275 PLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGS 330
Score = 48.9 bits (115), Expect = 6e-06
Identities = 62/233 (26%), Positives = 96/233 (41%), Gaps = 30/233 (12%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
++ Q+ G++ LH+AAI G + + L G+ + A++ G+T LH+A R G L
Sbjct: 299 VNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 174
+ DT D P H V L+ SD ++ S + + + N
Sbjct: 359 MT-------NGADTARRGIHDMFP--LHLAV-LFGFSDCCRKLLSSGQLYSIVSSLSNE- 407
Query: 175 GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
HV AG D++ P+ GR+ LH A + L LLL +GA+
Sbjct: 408 -----HVL-------------SAGFDINTPD-NLGRTCLHAAASGGNVECLNLLLSSGAD 448
Query: 235 PAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDS 287
R GRTPL A + A L GA E + + P ++ SD+
Sbjct: 449 LRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDT 501
Score = 48.5 bits (114), Expect = 7e-06
Identities = 57/218 (26%), Positives = 82/218 (37%), Gaps = 49/218 (22%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAER-RGHTALHLACRVGAHACARA 113
+D+++ G+TAL LA G T VE L A GA + ER R T LH A G
Sbjct: 611 LDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 670
Query: 114 LLQPRPRRP-REAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
L+ R + D Y
Sbjct: 671 LIDSGERADITDVMDAY------------------------------------------- 687
Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232
G TPL +A+++ V+ V LL + G+ D + GR+ LH D L LL
Sbjct: 688 --GQTPLMLAIMNGHVDCVHLLLEKGSTADAAD-LRGRTALHRGAVTGCEDCLAALLDHD 744
Query: 233 ANPAARMYGGRTPLG-SAMLRPNPILARLLRAHGAPEP 269
A R + GRTP+ ++ +L LL+A + +P
Sbjct: 745 AFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDP 782
Score = 45.1 bits (105), Expect = 8e-05
Identities = 46/177 (25%), Positives = 75/177 (42%), Gaps = 22/177 (12%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGL----CVAERRGHTALHLACRVGAHACARALLQP 117
G+T +HLA+ G T+ + L A + G++ +H A G C LL+
Sbjct: 754 GRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE- 812
Query: 118 RPRRPREAPDTYLAQGPDRTPDTNHTPV--ALYPDSDLEKEEEESEEDWKLQLEAENYEG 175
+P +YL P TP+ A+ + D E K+ + + + +G
Sbjct: 813 ------HSPFSYLEGNP-------FTPLHCAVINNQDSTTEMLLGALGAKI-VNSRDAKG 858
Query: 176 HTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232
TPLH A +V +R+L A+++ + T GR+ L A E +E LL G
Sbjct: 859 RTPLHAAAFADNVSGLRMLLQHQAEVNATDHT-GRTALMTAAENGQTAAVEFLLYRG 914
Score = 43.5 bits (101), Expect = 2e-04
Identities = 31/81 (38%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 36 SSSATSLRMGTRFSAGTEYMDLQNDLGQTALHLAAILGETSTVE-KLYAAGAGLCVAERR 94
+ + + LRM + A D G+TAL AA G+T+ VE LY A L V +
Sbjct: 868 ADNVSGLRMLLQHQAEVNATD---HTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDEN 924
Query: 95 GHTALHLACRVGAHACARALL 115
+TALHLAC G CA +L
Sbjct: 925 KNTALHLACSKGHEKCALMIL 945
Score = 42.4 bits (98), Expect = 5e-04
Identities = 32/89 (35%), Positives = 44/89 (49%), Gaps = 1/89 (1%)
Query: 178 PLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAA 237
PL A+ +DVE VR L +++ + R+PLH A +L+LLL +GAN A
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQE-RRTPLHAAAYVGDVPILQLLLMSGANVNA 69
Query: 238 RMYGGRTPLGSAMLRPNPILARLLRAHGA 266
+ TPL A N + LL AH A
Sbjct: 70 KDTLWLTPLHRAAASRNEKVLGLLLAHSA 98
Score = 42.0 bits (97), Expect = 7e-04
Identities = 32/91 (35%), Positives = 47/91 (51%), Gaps = 1/91 (1%)
Query: 156 EEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHL 215
EE S K + + E TPLH A DV +++LL +GA+++ + T +PLH
Sbjct: 22 EEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD-TLWLTPLHR 80
Query: 216 AVEAQAADVLELLLRAGANPAARMYGGRTPL 246
A ++ VL LLL A+ AR +TPL
Sbjct: 81 AAASRNEKVLGLLLAHSADVNARDKLWQTPL 111
Score = 37.4 bits (85), Expect = 0.017
Identities = 48/186 (25%), Positives = 67/186 (36%), Gaps = 17/186 (9%)
Query: 64 TALHLAAILGETSTVEKLYAAGAGLCVAER--RGHTALHLACRVGAHACARALLQPRPRR 121
T LH A I + ST E L A V R +G T LH A + R LLQ +
Sbjct: 825 TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAE- 883
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
+ T T T + ++ E K L + +T LH+
Sbjct: 884 ------------VNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHL 931
Query: 182 AVI--HKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARM 239
A H+ ++ L L + + PLH+A A V++ LL GA A
Sbjct: 932 ACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVD 991
Query: 240 YGGRTP 245
G TP
Sbjct: 992 EEGHTP 997
Score = 36.6 bits (83), Expect = 0.029
Identities = 46/193 (23%), Positives = 72/193 (37%), Gaps = 17/193 (8%)
Query: 78 VEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRT 137
+E L GA + +R+G+TA+H A G LL+ + T
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592
Query: 138 PDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDA 197
H E ++ + + L+ +++G T L +A E V +L
Sbjct: 593 AYNGHC------------EALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAH 640
Query: 198 GADLDKPEPTCGRSPLHLAVEAQAADVLELLL----RAGANPAARMYGGRTPLGSAMLRP 253
GA E +PLH A + D L LL+ RA Y G+TPL A++
Sbjct: 641 GASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAY-GQTPLMLAIMNG 699
Query: 254 NPILARLLRAHGA 266
+ LL G+
Sbjct: 700 HVDCVHLLLEKGS 712
Score = 31.6 bits (70), Expect = 0.92
Identities = 24/70 (34%), Positives = 32/70 (45%), Gaps = 4/70 (5%)
Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVG---AHACARALL 115
N Q LH+AA G S V+ L + GA + + GHT LAC A A L
Sbjct: 958 NSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPA-LACAPNKDVADCLALILS 1016
Query: 116 QPRPRRPREA 125
+P P++A
Sbjct: 1017 TMKPFPPKDA 1026
>gi|52486251 phospholipase A2, group VI isoform b [Homo sapiens]
Length = 752
Score = 69.3 bits (168), Expect = 4e-12
Identities = 65/214 (30%), Positives = 94/214 (43%), Gaps = 20/214 (9%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYA--AGAGLCVAERRGHTALHLACRVGAHACAR 112
MD+ + G+T H A + G+ S V +L A AGL +G T LHLAC++G R
Sbjct: 179 MDVTDYKGETVFHYA-VQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVR 237
Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
LL R P+ Y + + + DS ++ +
Sbjct: 238 VLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSS------------QIHSKDPR 285
Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232
Y G +PLH A K+ EM R+L G +++ + G + LH+AV D +LL G
Sbjct: 286 Y-GASPLHWA---KNAEMARMLLKRGCNVNSTS-SAGNTALHVAVMRNRFDCAIVLLTHG 340
Query: 233 ANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
AN AR G TPL AM + N + + L GA
Sbjct: 341 ANADARGEHGNTPLHLAMSKDNVEMIKALIVFGA 374
Score = 41.6 bits (96), Expect = 9e-04
Identities = 50/191 (26%), Positives = 81/191 (42%), Gaps = 26/191 (13%)
Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115
N+ G T LHLA LG+ V L A + G+ +H A + CA ++
Sbjct: 217 NNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEMIISMD 275
Query: 116 --QPRPRRPRE-APDTYLAQGPD-------RTPDTNHTPVALYPDSDLEKEEEESEEDWK 165
Q + PR A + A+ + R + N T A ++ L + D
Sbjct: 276 SSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSA--GNTALHVAVMRNRFDCA 333
Query: 166 LQL-------EAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLA-- 216
+ L +A G+TPLH+A+ +VEM++ L GA++D P G +P LA
Sbjct: 334 IVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPN-DFGETPTFLASK 392
Query: 217 VEAQAADVLEL 227
+ Q D++ +
Sbjct: 393 IGRQLQDLMHI 403
Score = 36.6 bits (83), Expect = 0.029
Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 7/96 (7%)
Query: 170 AENYEGHTPLHVAVIHKDVE-MVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELL 228
AEN EG TPLH+A D E +V L++ +D + G + H AV+ + VL+LL
Sbjct: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYK-GETVFHYAVQGDNSQVLQLL 205
Query: 229 LR---AGANPAARMYGGRTPLGSAMLRPNPILARLL 261
R AG N G TPL A + R+L
Sbjct: 206 GRNAVAGLNQVNNQ--GLTPLHLACQLGKQEMVRVL 239
Score = 35.4 bits (80), Expect = 0.064
Identities = 50/222 (22%), Positives = 80/222 (36%), Gaps = 49/222 (22%)
Query: 57 LQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQ 116
++N + HLA LG C G T LHLACR G L+Q
Sbjct: 114 IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQ 173
Query: 117 PRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176
HT Q++ +Y+G
Sbjct: 174 -----------------------YCHT-----------------------QMDVTDYKGE 187
Query: 177 TPLHVAVIHKDVEMVRLL-RDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANP 235
T H AV + ++++LL R+A A L++ G +PLHLA + +++ +LL A
Sbjct: 188 TVFHYAVQGDNSQVLQLLGRNAVAGLNQVN-NQGLTPLHLACQLGKQEMVRVLLLCNAR- 245
Query: 236 AARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSG 277
M P+ SAM A ++ + + + +D + G
Sbjct: 246 CNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYG 287
Score = 28.5 bits (62), Expect = 7.8
Identities = 26/89 (29%), Positives = 36/89 (40%), Gaps = 11/89 (12%)
Query: 29 RGCRGLPSSSA--TSLR---MGTRFSAGTEYM------DLQNDLGQTALHLAAILGETST 77
RGC +SSA T+L M RF + D + + G T LHLA
Sbjct: 306 RGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEM 365
Query: 78 VEKLYAAGAGLCVAERRGHTALHLACRVG 106
++ L GA + G T LA ++G
Sbjct: 366 IKALIVFGAEVDTPNDFGETPTFLASKIG 394
>gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens]
Length = 806
Score = 69.3 bits (168), Expect = 4e-12
Identities = 65/214 (30%), Positives = 94/214 (43%), Gaps = 20/214 (9%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYA--AGAGLCVAERRGHTALHLACRVGAHACAR 112
MD+ + G+T H A + G+ S V +L A AGL +G T LHLAC++G R
Sbjct: 179 MDVTDYKGETVFHYA-VQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVR 237
Query: 113 ALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAEN 172
LL R P+ Y + + + DS ++ +
Sbjct: 238 VLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSS------------QIHSKDPR 285
Query: 173 YEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAG 232
Y G +PLH A K+ EM R+L G +++ + G + LH+AV D +LL G
Sbjct: 286 Y-GASPLHWA---KNAEMARMLLKRGCNVNSTS-SAGNTALHVAVMRNRFDCAIVLLTHG 340
Query: 233 ANPAARMYGGRTPLGSAMLRPNPILARLLRAHGA 266
AN AR G TPL AM + N + + L GA
Sbjct: 341 ANADARGEHGNTPLHLAMSKDNVEMIKALIVFGA 374
Score = 41.2 bits (95), Expect = 0.001
Identities = 48/178 (26%), Positives = 75/178 (42%), Gaps = 24/178 (13%)
Query: 59 NDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL--- 115
N+ G T LHLA LG+ V L A + G+ +H A + CA ++
Sbjct: 217 NNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYP-IHSAMKFSQKGCAEMIISMD 275
Query: 116 --QPRPRRPRE-APDTYLAQGPD-------RTPDTNHTPVALYPDSDLEKEEEESEEDWK 165
Q + PR A + A+ + R + N T A ++ L + D
Sbjct: 276 SSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSA--GNTALHVAVMRNRFDCA 333
Query: 166 LQL-------EAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLA 216
+ L +A G+TPLH+A+ +VEM++ L GA++D P G +P LA
Sbjct: 334 IVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPN-DFGETPTFLA 390
Score = 36.6 bits (83), Expect = 0.029
Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 7/96 (7%)
Query: 170 AENYEGHTPLHVAVIHKDVE-MVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELL 228
AEN EG TPLH+A D E +V L++ +D + G + H AV+ + VL+LL
Sbjct: 147 AENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYK-GETVFHYAVQGDNSQVLQLL 205
Query: 229 LR---AGANPAARMYGGRTPLGSAMLRPNPILARLL 261
R AG N G TPL A + R+L
Sbjct: 206 GRNAVAGLNQVNNQ--GLTPLHLACQLGKQEMVRVL 239
Score = 35.4 bits (80), Expect = 0.064
Identities = 50/222 (22%), Positives = 80/222 (36%), Gaps = 49/222 (22%)
Query: 57 LQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQ 116
++N + HLA LG C G T LHLACR G L+Q
Sbjct: 114 IRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQ 173
Query: 117 PRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGH 176
HT Q++ +Y+G
Sbjct: 174 -----------------------YCHT-----------------------QMDVTDYKGE 187
Query: 177 TPLHVAVIHKDVEMVRLL-RDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANP 235
T H AV + ++++LL R+A A L++ G +PLHLA + +++ +LL A
Sbjct: 188 TVFHYAVQGDNSQVLQLLGRNAVAGLNQVN-NQGLTPLHLACQLGKQEMVRVLLLCNAR- 245
Query: 236 AARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSG 277
M P+ SAM A ++ + + + +D + G
Sbjct: 246 CNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYG 287
Score = 30.8 bits (68), Expect = 1.6
Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 11/98 (11%)
Query: 29 RGCRGLPSSSA--TSLR---MGTRFSAGTEYM------DLQNDLGQTALHLAAILGETST 77
RGC +SSA T+L M RF + D + + G T LHLA
Sbjct: 306 RGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEM 365
Query: 78 VEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
++ L GA + G T LA ++G +A+L
Sbjct: 366 IKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAIL 403
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 66.6 bits (161), Expect = 3e-11
Identities = 62/239 (25%), Positives = 105/239 (43%), Gaps = 23/239 (9%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G+TA HLAA G + + G + + GH+ALHLA + H C R LLQ
Sbjct: 53 GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ----- 107
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
++ P + D++ Y + + + + K + ++ +G+ PL +
Sbjct: 108 ---------SKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 158
Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
AV + E+ L D GAD++ + GR+ L LA E +++ +E L++ GA+
Sbjct: 159 AVQNGHSEICHFLLDHGADVNSRNKS-GRTALMLACEIGSSNAVEALIKKGADLNLVDSL 217
Query: 242 GRTPLGSAMLRPNPILARLLRAHGAPE--------PEGEDEKSGPCSSSSDSDSGDEGV 292
G L + L N + LL + + + P+ + S P S +S SG E V
Sbjct: 218 GYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKESV 276
Score = 37.7 bits (86), Expect = 0.013
Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 10/90 (11%)
Query: 58 QNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQP 117
+N G+TAL LA +G ++ VE L GA L + + G+ ALH + ++ +A ++LL
Sbjct: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS-KLSENAGIQSLLLS 239
Query: 118 R---------PRRPREAPDTYLAQGPDRTP 138
+ P +P++ D + TP
Sbjct: 240 KISQDADLKTPTKPKQLSDVSSPRSITSTP 269
Score = 37.4 bits (85), Expect = 0.017
Identities = 41/164 (25%), Positives = 67/164 (40%), Gaps = 19/164 (11%)
Query: 85 GAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPD--TNH 142
GA + G TA HLA G C R + + G D T T H
Sbjct: 43 GASATKHDSEGKTAFHLAAAKGHVECLRVM---------------ITHGVDVTAQDTTGH 87
Query: 143 TPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLD 202
+ + L + + + + K E+ + G T LH A ++ V++L + + ++
Sbjct: 88 SALHLAAKNSHHECIRKLLQS-KCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPIN 146
Query: 203 KPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPL 246
+ G PL LAV+ +++ LL GA+ +R GRT L
Sbjct: 147 LKD-LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 65.9 bits (159), Expect = 4e-11
Identities = 54/229 (23%), Positives = 106/229 (46%), Gaps = 22/229 (9%)
Query: 8 WAPWVRTQRPPEDLGWARSWARGCRGLPSSSATSLR--MGTRFSAGTEYMDLQNDLGQTA 65
+ PW+ + + W ++ R + + + A + +G + ++ T++ + G+TA
Sbjct: 5 YLPWLSAKEKKTN-EWNKNDDRLLQAVENGDAEKVASLLGKKGASATKH----DSEGKTA 59
Query: 66 LHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREA 125
HLAA G + + G + + GH+ALHLA + H C R LLQ
Sbjct: 60 FHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ--------- 110
Query: 126 PDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIH 185
++ P + D++ Y + + + + K + ++ +G+ PL +AV +
Sbjct: 111 -----SKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQN 165
Query: 186 KDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
E+ L D GAD++ + GR+ L LA E +++ +E L++ GA+
Sbjct: 166 GHSEICHFLLDHGADVNSRNKS-GRTALMLACEIGSSNAVEALIKKGAD 213
Score = 35.8 bits (81), Expect = 0.049
Identities = 21/58 (36%), Positives = 35/58 (60%), Gaps = 1/58 (1%)
Query: 58 QNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
+N G+TAL LA +G ++ VE L GA L + + G+ ALH + ++ +A ++LL
Sbjct: 184 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS-KLSENAGIQSLL 240
Score = 35.0 bits (79), Expect = 0.083
Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 1/94 (1%)
Query: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233
EG T H+A VE +R++ G D+ + T G S LHLA + + + LL++
Sbjct: 55 EGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT-GHSALHLAAKNSHHECIRKLLQSKC 113
Query: 234 NPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
+ G+T L A + ++L H +P
Sbjct: 114 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 147
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 65.5 bits (158), Expect = 6e-11
Identities = 67/207 (32%), Positives = 86/207 (41%), Gaps = 14/207 (6%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G+T LHLAA + +L AGA +R G T LH A A + LL+ R
Sbjct: 1634 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSR--- 1690
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
+ A D RT D TP+ L +E EE + + A + G T LH
Sbjct: 1691 -QTAVDA-------RTED-GTTPLMLAARLAVEDLVEELIAA-QADVGARDKWGKTALHW 1740
Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYG 241
A + R L AGAD D + ++PL LA A +V +LLL GA R
Sbjct: 1741 AAAVNNARAARSLLQAGADKD-AQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQA 1799
Query: 242 GRTPLGSAMLRPNPILARLLRAHGAPE 268
G P A R + L LL G PE
Sbjct: 1800 GLAPADVAHQRNHWDLLTLLEGAGPPE 1826
Score = 42.0 bits (97), Expect = 7e-04
Identities = 33/104 (31%), Positives = 46/104 (44%)
Query: 175 GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
G TPLH AV E+ +LL + G +PL LA D++E L+ A A+
Sbjct: 1667 GRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQAD 1726
Query: 235 PAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP 278
AR G+T L A N AR L GA + ++ + P
Sbjct: 1727 VGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTP 1770
Score = 41.6 bits (96), Expect = 9e-04
Identities = 51/184 (27%), Positives = 72/184 (39%), Gaps = 49/184 (26%)
Query: 55 MDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARAL 114
+D + + G T L LAA L VE+L AA A + ++ G TALH A V AR+L
Sbjct: 1694 VDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSL 1753
Query: 115 LQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYE 174
LQ G D+ +A++
Sbjct: 1754 LQ---------------AGADK--------------------------------DAQDNR 1766
Query: 175 GHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
TPL +A VE+ +LL GA + + G +P +A + D+L LL AG
Sbjct: 1767 EQTPLFLAAREGAVEVAQLLLGLGAARELRD-QAGLAPADVAHQRNHWDLLTLLEGAGP- 1824
Query: 235 PAAR 238
P AR
Sbjct: 1825 PEAR 1828
Score = 39.3 bits (90), Expect = 0.004
Identities = 38/118 (32%), Positives = 49/118 (41%), Gaps = 20/118 (16%)
Query: 149 PDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEP-- 206
P + + +ESE + L+ +G TPL AV +V+ GA L PEP
Sbjct: 1562 PQAAMLTPPQESEMEAP-DLDTRGPDGVTPLMSAVCCGEVQSGTF---QGAWLGCPEPWE 1617
Query: 207 ------TC--------GRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAM 250
C G +PLHLA LL AGANP GRTPL +A+
Sbjct: 1618 PLLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAV 1675
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 65.5 bits (158), Expect = 6e-11
Identities = 47/173 (27%), Positives = 82/173 (47%), Gaps = 15/173 (8%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G+TA HLAA G + + G + + GH+ALHLA + H C R LLQ
Sbjct: 45 GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ----- 99
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
++ P + D++ Y + + + + K + ++ +G+ PL +
Sbjct: 100 ---------SKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 150
Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
AV + E+ L D GAD++ + GR+ L LA E +++ +E L++ GA+
Sbjct: 151 AVQNGHSEICHFLLDHGADVNSRNKS-GRTALMLACEIGSSNAVEALIKKGAD 202
Score = 35.8 bits (81), Expect = 0.049
Identities = 21/58 (36%), Positives = 35/58 (60%), Gaps = 1/58 (1%)
Query: 58 QNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
+N G+TAL LA +G ++ VE L GA L + + G+ ALH + ++ +A ++LL
Sbjct: 173 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS-KLSENAGIQSLL 229
Score = 35.0 bits (79), Expect = 0.083
Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 1/94 (1%)
Query: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233
EG T H+A VE +R++ G D+ + T G S LHLA + + + LL++
Sbjct: 44 EGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT-GHSALHLAAKNSHHECIRKLLQSKC 102
Query: 234 NPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
+ G+T L A + ++L H +P
Sbjct: 103 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 136
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 65.5 bits (158), Expect = 6e-11
Identities = 47/173 (27%), Positives = 82/173 (47%), Gaps = 15/173 (8%)
Query: 62 GQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRR 121
G+TA HLAA G + + G + + GH+ALHLA + H C R LLQ
Sbjct: 53 GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ----- 107
Query: 122 PREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHV 181
++ P + D++ Y + + + + K + ++ +G+ PL +
Sbjct: 108 ---------SKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLL 158
Query: 182 AVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGAN 234
AV + E+ L D GAD++ + GR+ L LA E +++ +E L++ GA+
Sbjct: 159 AVQNGHSEICHFLLDHGADVNSRNKS-GRTALMLACEIGSSNAVEALIKKGAD 210
Score = 35.8 bits (81), Expect = 0.049
Identities = 21/58 (36%), Positives = 35/58 (60%), Gaps = 1/58 (1%)
Query: 58 QNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALL 115
+N G+TAL LA +G ++ VE L GA L + + G+ ALH + ++ +A ++LL
Sbjct: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS-KLSENAGIQSLL 237
Score = 35.0 bits (79), Expect = 0.083
Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 1/94 (1%)
Query: 174 EGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGA 233
EG T H+A VE +R++ G D+ + T G S LHLA + + + LL++
Sbjct: 52 EGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT-GHSALHLAAKNSHHECIRKLLQSKC 110
Query: 234 NPAARMYGGRTPLGSAMLRPNPILARLLRAHGAP 267
+ G+T L A + ++L H +P
Sbjct: 111 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 144
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,566,283
Number of Sequences: 37866
Number of extensions: 796723
Number of successful extensions: 7525
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 334
Number of HSP's successfully gapped in prelim test: 100
Number of HSP's that attempted gapping in prelim test: 4135
Number of HSP's gapped (non-prelim): 2094
length of query: 306
length of database: 18,247,518
effective HSP length: 102
effective length of query: 204
effective length of database: 14,385,186
effective search space: 2934577944
effective search space used: 2934577944
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.