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Search of human proteins with 4885455
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4885455 SH2B adaptor protein 3 [Homo sapiens]
(575 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4885455 SH2B adaptor protein 3 [Homo sapiens] 1190 0.0
gi|242247193 SH2B adaptor protein 2 [Homo sapiens] 264 1e-70
gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens] 164 3e-40
gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens] 162 1e-39
gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 158 1e-38
gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 158 1e-38
gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 158 1e-38
gi|194239668 SHC (Src homology 2 domain containing) transforming... 59 9e-09
gi|194239662 SHC (Src homology 2 domain containing) transforming... 59 9e-09
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 55 1e-07
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 55 1e-07
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 55 1e-07
gi|194239664 SHC (Src homology 2 domain containing) transforming... 55 2e-07
gi|32261324 SHC (Src homology 2 domain containing) transforming ... 55 2e-07
gi|222537752 Src homology 2 domain containing transforming prote... 52 1e-06
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 51 3e-06
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 51 3e-06
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 51 3e-06
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 51 3e-06
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 51 3e-06
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 51 3e-06
gi|169790811 SHC (Src homology 2 domain containing) transforming... 51 3e-06
gi|187475373 c-src tyrosine kinase [Homo sapiens] 51 3e-06
gi|4758078 c-src tyrosine kinase [Homo sapiens] 51 3e-06
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 50 7e-06
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 50 7e-06
gi|224586793 src homology 2 domain-containing transforming prote... 49 1e-05
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 49 1e-05
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 49 1e-05
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens] 48 2e-05
>gi|4885455 SH2B adaptor protein 3 [Homo sapiens]
Length = 575
Score = 1190 bits (3079), Expect = 0.0
Identities = 575/575 (100%), Positives = 575/575 (100%)
Query: 1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA 60
MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA
Sbjct: 1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA 60
Query: 61 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS 120
ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS
Sbjct: 61 ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS 120
Query: 121 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK 180
SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK
Sbjct: 121 SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK 180
Query: 181 KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF 240
KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF
Sbjct: 181 KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF 240
Query: 241 DPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA 300
DPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA
Sbjct: 241 DPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA 300
Query: 301 ELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS 360
ELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS
Sbjct: 301 ELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS 360
Query: 361 CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE 420
CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE
Sbjct: 361 CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE 420
Query: 421 RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS 480
RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS
Sbjct: 421 RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS 480
Query: 481 LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ 540
LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ
Sbjct: 481 LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ 540
Query: 541 HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL 575
HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
Sbjct: 541 HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL 575
>gi|242247193 SH2B adaptor protein 2 [Homo sapiens]
Length = 675
Score = 264 bits (675), Expect = 1e-70
Identities = 229/657 (34%), Positives = 297/657 (45%), Gaps = 111/657 (16%)
Query: 1 MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQH-APLR 59
MNG P ++AP P P W +FCELHA AAA + A ++ F R++P + P
Sbjct: 44 MNGAG--PGPAAAAPVPVPVPVP-DWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDA 100
Query: 60 AELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEA-SPEPGPGPAAPGLP-- 116
S F F F EVR G T RG AEA PE A P
Sbjct: 101 GASFSRHFAANFLDVFGEEVRRVLVAG----PTTRGAAVSAEAMEPELADTSALKAAPYG 156
Query: 117 KARSSEEL---APPRPPGPCSFQHFRRSL------RHIFRRRSAGELPAAHTAAAPGTPG 167
+RSSE++ A + F SL R ++ RR++ P AAAP T
Sbjct: 157 HSRSSEDVSTHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRAS---PEPDAAAAPRTAE 213
Query: 168 EAAETPARPGLAKKFLPWSLAREPPPEALKEAVLRYSLADEASMDSG--ARWQRGRLALR 225
+ R L++ A+ + +E LR+ +AD+A+ SG A+WQ+ RL LR
Sbjct: 214 PRDKWTRRLRLSRTLA----AKVELVDIQREGALRFMVADDAAAGSGGSAQWQKCRLLLR 269
Query: 226 RAPGPDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDI 285
RA + LE F PPK+SRPK+ S+I EVR LEMP+ TFVLKV++ +
Sbjct: 270 RAVAEERFR--LEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEY 327
Query: 286 IFEVGDEQQLNSWMAELS--------------ECTGRGL--------------------- 310
I E D Q +SW+A++ CT G
Sbjct: 328 ILETIDSLQKHSWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPR 387
Query: 311 --EST------------------EAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDP 350
E+T E+ +H+P T SP GS N G DP
Sbjct: 388 PPETTAVGAVVTAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDP 447
Query: 351 ACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGI 410
+ + LS YPWFHG +SRVKAAQLV GP HG+F++RQSETR GEYVLTFNFQG
Sbjct: 448 EAEP-ELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGK 506
Query: 411 AKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPG 470
AKHLRLSL GQC VQHL F SV+DML HF PIPLE G + D+ L SYV PP
Sbjct: 507 AKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADITLRSYVRAQDPPPE 566
Query: 471 SCNT-VLFPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSS--------- 520
T P S W H+ S L+++ CP SP G SS
Sbjct: 567 PGPTPPAAPASPACWSDSPGQHYFSS-----LAAAACPPA-SPSDAAGASSSSASSSSAA 620
Query: 521 ----PPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYT 573
PP + + S +NS + L A + E ++ RA++NQY+
Sbjct: 621 SGPAPPRPVEGQL-SARSRSNSAERLLEAVAATAAE---EPPEAAPGRARAVENQYS 673
>gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens]
Length = 756
Score = 164 bits (414), Expect = 3e-40
Identities = 111/275 (40%), Positives = 138/275 (50%), Gaps = 25/275 (9%)
Query: 317 MHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQ 376
+H SA P + + L QG GG + D LS YPWFHG +SR+KAAQ
Sbjct: 487 VHPLSAPYPPLDTPETATGSFLFQGEPEGG-------EGDQPLSGYPWFHGMLSRLKAAQ 539
Query: 377 LVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVD 436
LV G +HGVFLVRQSETRRGEYVLTFNFQG AKHLRLSL E GQCRVQHL F S+ D
Sbjct: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599
Query: 437 MLHHFQRSPIPLECGAACDVRLSSYVVVV--SQPPGSCNTVLFPFSLPHWDSESLPHWGS 494
ML HF+ PIPLE G + DV L SYV Q P + + P P W P
Sbjct: 600 MLEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQEPTTSHDPPQPPEPPSWTDPPQPGAEE 659
Query: 495 ELGLPHLSSSGCPRGLSPE--------GLPGRSSPPEQIFHLVPSPEEL--------ANS 538
P ++++ + G+P P ++ +V E + A S
Sbjct: 660 ASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAGS 719
Query: 539 LQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYT 573
P+ + + S D H RAI+NQY+
Sbjct: 720 GGDAGVPPMVQLQQSPLGGDGEEGGHPRAINNQYS 754
Score = 131 bits (330), Expect = 1e-30
Identities = 127/409 (31%), Positives = 177/409 (43%), Gaps = 91/409 (22%)
Query: 9 SSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELV-SLQF 67
+SPSS P P P W EFCE HA AAA + AR++ L+ HPQ+A AE S +F
Sbjct: 11 ASPSSPPLPPPP--PPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRF 68
Query: 68 TDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASP--EPGP-----------GPAAPG 114
+LF ++F EV RA G PP A SP E P GP A
Sbjct: 69 AELFLQHFEAEV--ARASG------SLSPPILAPLSPGAEISPHDLSLESCRVGGPLAV- 119
Query: 115 LPKARSSEELAPPRPPGPCSF-------------------QHFRRSLRHIFRRRSAGELP 155
L +RSSE+LA P P S + R S+R I + R + P
Sbjct: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179
Query: 156 AA----HTAAAPGTPGEAAETPARPGLAK------------------KFLPWSLAR---- 189
++ T++ P G + + + G +F L+R
Sbjct: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239
Query: 190 --EPPPEALKEAVLRYSLADEASMDSGA------------------RWQRGRLALRRAPG 229
+ +E +L + A+EA+ D +WQ+ RL LR + G
Sbjct: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLR-SEG 298
Query: 230 PDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEV 289
G LE F PPK+SRP+L CSSI +VR T LEMPD TFV+KV+ ++ I E
Sbjct: 299 EGGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMET 358
Query: 290 GDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSL 338
D Q + +W++++ EC G + + L P TS R +TDSL
Sbjct: 359 VDAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSL 407
>gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]
Length = 683
Score = 162 bits (409), Expect = 1e-39
Identities = 101/208 (48%), Positives = 118/208 (56%), Gaps = 15/208 (7%)
Query: 317 MHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQ 376
+H SA P + + L QG GG + D LS YPWFHG +SR+KAAQ
Sbjct: 487 VHPLSAPYPPLDTPETATGSFLFQGEPEGG-------EGDQPLSGYPWFHGMLSRLKAAQ 539
Query: 377 LVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVD 436
LV G +HGVFLVRQSETRRGEYVLTFNFQG AKHLRLSL E GQCRVQHL F S+ D
Sbjct: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599
Query: 437 MLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSEL 496
ML HF+ PIPLE G + DV L SYV + G + H SE+ GS L
Sbjct: 600 MLEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEA----GSRL 655
Query: 497 GLPHLSSSGCPRGLSPEGLPGRSSPPEQ 524
G + GC R + +P S P +
Sbjct: 656 G----AMRGCAREMDATPMPPAPSCPSE 679
Score = 131 bits (330), Expect = 1e-30
Identities = 127/409 (31%), Positives = 177/409 (43%), Gaps = 91/409 (22%)
Query: 9 SSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELV-SLQF 67
+SPSS P P P W EFCE HA AAA + AR++ L+ HPQ+A AE S +F
Sbjct: 11 ASPSSPPLPPPP--PPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRF 68
Query: 68 TDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASP--EPGP-----------GPAAPG 114
+LF ++F EV RA G PP A SP E P GP A
Sbjct: 69 AELFLQHFEAEV--ARASG------SLSPPILAPLSPGAEISPHDLSLESCRVGGPLAV- 119
Query: 115 LPKARSSEELAPPRPPGPCSF-------------------QHFRRSLRHIFRRRSAGELP 155
L +RSSE+LA P P S + R S+R I + R + P
Sbjct: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179
Query: 156 AA----HTAAAPGTPGEAAETPARPGLAK------------------KFLPWSLAR---- 189
++ T++ P G + + + G +F L+R
Sbjct: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239
Query: 190 --EPPPEALKEAVLRYSLADEASMDSGA------------------RWQRGRLALRRAPG 229
+ +E +L + A+EA+ D +WQ+ RL LR + G
Sbjct: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLR-SEG 298
Query: 230 PDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEV 289
G LE F PPK+SRP+L CSSI +VR T LEMPD TFV+KV+ ++ I E
Sbjct: 299 EGGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMET 358
Query: 290 GDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSL 338
D Q + +W++++ EC G + + L P TS R +TDSL
Sbjct: 359 VDAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSL 407
>gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 158 bits (399), Expect = 1e-38
Identities = 87/146 (59%), Positives = 97/146 (66%), Gaps = 7/146 (4%)
Query: 317 MHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQ 376
+H SA P + + L QG GG + D LS YPWFHG +SR+KAAQ
Sbjct: 487 VHPLSAPYPPLDTPETATGSFLFQGEPEGG-------EGDQPLSGYPWFHGMLSRLKAAQ 539
Query: 377 LVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVD 436
LV G +HGVFLVRQSETRRGEYVLTFNFQG AKHLRLSL E GQCRVQHL F S+ D
Sbjct: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599
Query: 437 MLHHFQRSPIPLECGAACDVRLSSYV 462
ML HF+ PIPLE G + DV L SYV
Sbjct: 600 MLEHFRVHPIPLESGGSSDVVLVSYV 625
Score = 131 bits (330), Expect = 1e-30
Identities = 127/409 (31%), Positives = 177/409 (43%), Gaps = 91/409 (22%)
Query: 9 SSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELV-SLQF 67
+SPSS P P P W EFCE HA AAA + AR++ L+ HPQ+A AE S +F
Sbjct: 11 ASPSSPPLPPPP--PPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRF 68
Query: 68 TDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASP--EPGP-----------GPAAPG 114
+LF ++F EV RA G PP A SP E P GP A
Sbjct: 69 AELFLQHFEAEV--ARASG------SLSPPILAPLSPGAEISPHDLSLESCRVGGPLAV- 119
Query: 115 LPKARSSEELAPPRPPGPCSF-------------------QHFRRSLRHIFRRRSAGELP 155
L +RSSE+LA P P S + R S+R I + R + P
Sbjct: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179
Query: 156 AA----HTAAAPGTPGEAAETPARPGLAK------------------KFLPWSLAR---- 189
++ T++ P G + + + G +F L+R
Sbjct: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239
Query: 190 --EPPPEALKEAVLRYSLADEASMDSGA------------------RWQRGRLALRRAPG 229
+ +E +L + A+EA+ D +WQ+ RL LR + G
Sbjct: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLR-SEG 298
Query: 230 PDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEV 289
G LE F PPK+SRP+L CSSI +VR T LEMPD TFV+KV+ ++ I E
Sbjct: 299 EGGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMET 358
Query: 290 GDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSL 338
D Q + +W++++ EC G + + L P TS R +TDSL
Sbjct: 359 VDAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSL 407
>gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 158 bits (399), Expect = 1e-38
Identities = 87/146 (59%), Positives = 97/146 (66%), Gaps = 7/146 (4%)
Query: 317 MHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQ 376
+H SA P + + L QG GG + D LS YPWFHG +SR+KAAQ
Sbjct: 487 VHPLSAPYPPLDTPETATGSFLFQGEPEGG-------EGDQPLSGYPWFHGMLSRLKAAQ 539
Query: 377 LVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVD 436
LV G +HGVFLVRQSETRRGEYVLTFNFQG AKHLRLSL E GQCRVQHL F S+ D
Sbjct: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599
Query: 437 MLHHFQRSPIPLECGAACDVRLSSYV 462
ML HF+ PIPLE G + DV L SYV
Sbjct: 600 MLEHFRVHPIPLESGGSSDVVLVSYV 625
Score = 131 bits (330), Expect = 1e-30
Identities = 127/409 (31%), Positives = 177/409 (43%), Gaps = 91/409 (22%)
Query: 9 SSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELV-SLQF 67
+SPSS P P P W EFCE HA AAA + AR++ L+ HPQ+A AE S +F
Sbjct: 11 ASPSSPPLPPPP--PPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRF 68
Query: 68 TDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASP--EPGP-----------GPAAPG 114
+LF ++F EV RA G PP A SP E P GP A
Sbjct: 69 AELFLQHFEAEV--ARASG------SLSPPILAPLSPGAEISPHDLSLESCRVGGPLAV- 119
Query: 115 LPKARSSEELAPPRPPGPCSF-------------------QHFRRSLRHIFRRRSAGELP 155
L +RSSE+LA P P S + R S+R I + R + P
Sbjct: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179
Query: 156 AA----HTAAAPGTPGEAAETPARPGLAK------------------KFLPWSLAR---- 189
++ T++ P G + + + G +F L+R
Sbjct: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239
Query: 190 --EPPPEALKEAVLRYSLADEASMDSGA------------------RWQRGRLALRRAPG 229
+ +E +L + A+EA+ D +WQ+ RL LR + G
Sbjct: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLR-SEG 298
Query: 230 PDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEV 289
G LE F PPK+SRP+L CSSI +VR T LEMPD TFV+KV+ ++ I E
Sbjct: 299 EGGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMET 358
Query: 290 GDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSL 338
D Q + +W++++ EC G + + L P TS R +TDSL
Sbjct: 359 VDAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSL 407
>gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 158 bits (399), Expect = 1e-38
Identities = 87/146 (59%), Positives = 97/146 (66%), Gaps = 7/146 (4%)
Query: 317 MHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQ 376
+H SA P + + L QG GG + D LS YPWFHG +SR+KAAQ
Sbjct: 487 VHPLSAPYPPLDTPETATGSFLFQGEPEGG-------EGDQPLSGYPWFHGMLSRLKAAQ 539
Query: 377 LVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVD 436
LV G +HGVFLVRQSETRRGEYVLTFNFQG AKHLRLSL E GQCRVQHL F S+ D
Sbjct: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599
Query: 437 MLHHFQRSPIPLECGAACDVRLSSYV 462
ML HF+ PIPLE G + DV L SYV
Sbjct: 600 MLEHFRVHPIPLESGGSSDVVLVSYV 625
Score = 131 bits (330), Expect = 1e-30
Identities = 127/409 (31%), Positives = 177/409 (43%), Gaps = 91/409 (22%)
Query: 9 SSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELV-SLQF 67
+SPSS P P P W EFCE HA AAA + AR++ L+ HPQ+A AE S +F
Sbjct: 11 ASPSSPPLPPPP--PPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRF 68
Query: 68 TDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASP--EPGP-----------GPAAPG 114
+LF ++F EV RA G PP A SP E P GP A
Sbjct: 69 AELFLQHFEAEV--ARASG------SLSPPILAPLSPGAEISPHDLSLESCRVGGPLAV- 119
Query: 115 LPKARSSEELAPPRPPGPCSF-------------------QHFRRSLRHIFRRRSAGELP 155
L +RSSE+LA P P S + R S+R I + R + P
Sbjct: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179
Query: 156 AA----HTAAAPGTPGEAAETPARPGLAK------------------KFLPWSLAR---- 189
++ T++ P G + + + G +F L+R
Sbjct: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239
Query: 190 --EPPPEALKEAVLRYSLADEASMDSGA------------------RWQRGRLALRRAPG 229
+ +E +L + A+EA+ D +WQ+ RL LR + G
Sbjct: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLR-SEG 298
Query: 230 PDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEV 289
G LE F PPK+SRP+L CSSI +VR T LEMPD TFV+KV+ ++ I E
Sbjct: 299 EGGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMET 358
Query: 290 GDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSL 338
D Q + +W++++ EC G + + L P TS R +TDSL
Sbjct: 359 VDAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSL 407
>gi|194239668 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 4 [Homo sapiens]
Length = 473
Score = 59.3 bits (142), Expect = 9e-09
Identities = 48/173 (27%), Positives = 74/173 (42%), Gaps = 19/173 (10%)
Query: 289 VGDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLL 348
VG + ++ M C GR L + +++ + + + G + G++P L
Sbjct: 290 VGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLF 349
Query: 349 D-------------PACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSE 395
D P L PWFHG +SR +A L+QL G FLVR+S
Sbjct: 350 DMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVREST 404
Query: 396 TRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPL 448
T G+YVLT G KHL L + G R + F SV ++ + + +P+
Sbjct: 405 TTPGQYVLTGLQSGQPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPI 456
>gi|194239662 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 1 [Homo sapiens]
Length = 583
Score = 59.3 bits (142), Expect = 9e-09
Identities = 48/173 (27%), Positives = 74/173 (42%), Gaps = 19/173 (10%)
Query: 289 VGDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLL 348
VG + ++ M C GR L + +++ + + + G + G++P L
Sbjct: 400 VGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLF 459
Query: 349 D-------------PACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSE 395
D P L PWFHG +SR +A L+QL G FLVR+S
Sbjct: 460 DMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVREST 514
Query: 396 TRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPL 448
T G+YVLT G KHL L + G R + F SV ++ + + +P+
Sbjct: 515 TTPGQYVLTGLQSGQPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPI 566
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 55.5 bits (132), Expect = 1e-07
Identities = 38/110 (34%), Positives = 56/110 (50%), Gaps = 8/110 (7%)
Query: 345 GGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLT 404
G L + D LS PWFHG IS +A Q QLQ P+ G+FLVR+S G+YVL
Sbjct: 62 GALREREALSADPKLSLMPWFHGKISGQEAVQ--QLQPPE-DGLFLVRESARHPGDYVLC 118
Query: 405 FNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAAC 454
+F H R+ + + + F +++DM+ H+ + + GA C
Sbjct: 119 VSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSK-----DKGAIC 163
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 55.5 bits (132), Expect = 1e-07
Identities = 38/110 (34%), Positives = 56/110 (50%), Gaps = 8/110 (7%)
Query: 345 GGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLT 404
G L + D LS PWFHG IS +A Q QLQ P+ G+FLVR+S G+YVL
Sbjct: 104 GALREREALSADPKLSLMPWFHGKISGQEAVQ--QLQPPE-DGLFLVRESARHPGDYVLC 160
Query: 405 FNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAAC 454
+F H R+ + + + F +++DM+ H+ + + GA C
Sbjct: 161 VSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSK-----DKGAIC 205
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 55.5 bits (132), Expect = 1e-07
Identities = 38/110 (34%), Positives = 56/110 (50%), Gaps = 8/110 (7%)
Query: 345 GGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLT 404
G L + D LS PWFHG IS +A Q QLQ P+ G+FLVR+S G+YVL
Sbjct: 103 GALREREALSADPKLSLMPWFHGKISGQEAVQ--QLQPPE-DGLFLVRESARHPGDYVLC 159
Query: 405 FNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAAC 454
+F H R+ + + + F +++DM+ H+ + + GA C
Sbjct: 160 VSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSK-----DKGAIC 204
>gi|194239664 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 3 [Homo sapiens]
Length = 584
Score = 55.1 bits (131), Expect = 2e-07
Identities = 34/86 (39%), Positives = 47/86 (54%), Gaps = 6/86 (6%)
Query: 363 PWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERG 422
PWFHG +SR +A L+QL G FLVR+S T G+YVLT G KHL L + G
Sbjct: 488 PWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSGQPKHL-LLVDPEG 541
Query: 423 QCRVQHLHFPSVVDMLHHFQRSPIPL 448
R + F SV ++ + + +P+
Sbjct: 542 VVRTKDHRFESVSHLISYHMDNHLPI 567
>gi|32261324 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 2 [Homo sapiens]
Length = 474
Score = 55.1 bits (131), Expect = 2e-07
Identities = 34/86 (39%), Positives = 47/86 (54%), Gaps = 6/86 (6%)
Query: 363 PWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERG 422
PWFHG +SR +A L+QL G FLVR+S T G+YVLT G KHL L + G
Sbjct: 378 PWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSGQPKHL-LLVDPEG 431
Query: 423 QCRVQHLHFPSVVDMLHHFQRSPIPL 448
R + F SV ++ + + +P+
Sbjct: 432 VVRTKDHRFESVSHLISYHMDNHLPI 457
>gi|222537752 Src homology 2 domain containing transforming protein
D [Homo sapiens]
Length = 340
Score = 52.4 bits (124), Expect = 1e-06
Identities = 43/128 (33%), Positives = 62/128 (48%), Gaps = 14/128 (10%)
Query: 344 PGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVL 403
P +DPA L PWFHGP++R A L+ L G +LVR SET + L
Sbjct: 225 PAERVDPALP-----LEKQPWFHGPLNRADAESLLSL---CKEGSYLVRLSETNPQDCSL 276
Query: 404 TFNFQGIAKHLRLSLTERGQCRV-QHL-HFPSVVDMLHHFQRSPIPLECGAACDVRLSSY 461
+ HL+ + T Q + QH FPSV +++ H+ P+P++ GA L+
Sbjct: 277 SLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQ-GAE---HLALL 332
Query: 462 VVVVSQPP 469
VV+Q P
Sbjct: 333 YPVVTQTP 340
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 51.2 bits (121), Expect = 3e-06
Identities = 30/102 (29%), Positives = 52/102 (50%), Gaps = 9/102 (8%)
Query: 340 QGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRG 399
QG P + P + L + W+HGP+SR A L+ +G FLVR+SE+ G
Sbjct: 139 QGWVPSNYITPV-----NSLEKHSWYHGPVSRSAAEYLLSSL---INGSFLVRESESSPG 190
Query: 400 EYVLTFNFQGIAKHLRLSLTERGQCRV-QHLHFPSVVDMLHH 440
+ ++ ++G H R++ T G+ V F ++ +++HH
Sbjct: 191 QLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 232
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 51.2 bits (121), Expect = 3e-06
Identities = 30/102 (29%), Positives = 52/102 (50%), Gaps = 9/102 (8%)
Query: 340 QGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRG 399
QG P + P + L + W+HGP+SR A L+ +G FLVR+SE+ G
Sbjct: 154 QGWVPSNYITPV-----NSLEKHSWYHGPVSRSAAEYLLSSL---INGSFLVRESESSPG 205
Query: 400 EYVLTFNFQGIAKHLRLSLTERGQCRV-QHLHFPSVVDMLHH 440
+ ++ ++G H R++ T G+ V F ++ +++HH
Sbjct: 206 QLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 247
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 51.2 bits (121), Expect = 3e-06
Identities = 30/102 (29%), Positives = 52/102 (50%), Gaps = 9/102 (8%)
Query: 340 QGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRG 399
QG P + P + L + W+HGP+SR A L+ +G FLVR+SE+ G
Sbjct: 133 QGWVPSNYITPV-----NSLEKHSWYHGPVSRSAAEYLLSSL---INGSFLVRESESSPG 184
Query: 400 EYVLTFNFQGIAKHLRLSLTERGQCRV-QHLHFPSVVDMLHH 440
+ ++ ++G H R++ T G+ V F ++ +++HH
Sbjct: 185 QLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 226
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 51.2 bits (121), Expect = 3e-06
Identities = 30/102 (29%), Positives = 52/102 (50%), Gaps = 9/102 (8%)
Query: 340 QGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRG 399
QG P + P + L + W+HGP+SR A L+ +G FLVR+SE+ G
Sbjct: 139 QGWVPSNYITPV-----NSLEKHSWYHGPVSRSAAEYLLSSL---INGSFLVRESESSPG 190
Query: 400 EYVLTFNFQGIAKHLRLSLTERGQCRV-QHLHFPSVVDMLHH 440
+ ++ ++G H R++ T G+ V F ++ +++HH
Sbjct: 191 QLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 232
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 51.2 bits (121), Expect = 3e-06
Identities = 30/102 (29%), Positives = 52/102 (50%), Gaps = 9/102 (8%)
Query: 340 QGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRG 399
QG P + P + L + W+HGP+SR A L+ +G FLVR+SE+ G
Sbjct: 118 QGWVPSNYITPV-----NSLEKHSWYHGPVSRSAAEYLLSSL---INGSFLVRESESSPG 169
Query: 400 EYVLTFNFQGIAKHLRLSLTERGQCRV-QHLHFPSVVDMLHH 440
+ ++ ++G H R++ T G+ V F ++ +++HH
Sbjct: 170 QLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 211
>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
sapiens]
Length = 475
Score = 51.2 bits (121), Expect = 3e-06
Identities = 33/94 (35%), Positives = 50/94 (53%), Gaps = 6/94 (6%)
Query: 355 TDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHL 414
T+ L PW+HG +SR A ++++ A G FLVR S T G+YVLT G KHL
Sbjct: 371 TEEQLRQEPWYHGRMSRRAAERMLR-----ADGDFLVRDSVTNPGQYVLTGMHAGQPKHL 425
Query: 415 RLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPL 448
L + G R + + F S+ ++ H ++ P+
Sbjct: 426 -LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPI 458
>gi|169790811 SHC (Src homology 2 domain containing) transforming
protein 2 [Homo sapiens]
Length = 582
Score = 51.2 bits (121), Expect = 3e-06
Identities = 33/94 (35%), Positives = 50/94 (53%), Gaps = 6/94 (6%)
Query: 355 TDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHL 414
T+ L PW+HG +SR A ++++ A G FLVR S T G+YVLT G KHL
Sbjct: 478 TEEQLRQEPWYHGRMSRRAAERMLR-----ADGDFLVRDSVTNPGQYVLTGMHAGQPKHL 532
Query: 415 RLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPL 448
L + G R + + F S+ ++ H ++ P+
Sbjct: 533 -LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPI 565
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 50.8 bits (120), Expect = 3e-06
Identities = 26/83 (31%), Positives = 45/83 (54%), Gaps = 3/83 (3%)
Query: 359 LSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSL 418
LS PWFHG I+R +A +L+ P G+FLVR+S G+Y L + G +H R+
Sbjct: 77 LSLMPWFHGKITREQAERLLY---PPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMY 133
Query: 419 TERGQCRVQHLHFPSVVDMLHHF 441
+ ++F +++ ++ H+
Sbjct: 134 HASKLSIDEEVYFENLMQLVEHY 156
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 50.8 bits (120), Expect = 3e-06
Identities = 26/83 (31%), Positives = 45/83 (54%), Gaps = 3/83 (3%)
Query: 359 LSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSL 418
LS PWFHG I+R +A +L+ P G+FLVR+S G+Y L + G +H R+
Sbjct: 77 LSLMPWFHGKITREQAERLLY---PPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMY 133
Query: 419 TERGQCRVQHLHFPSVVDMLHHF 441
+ ++F +++ ++ H+
Sbjct: 134 HASKLSIDEEVYFENLMQLVEHY 156
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 49.7 bits (117), Expect = 7e-06
Identities = 29/102 (28%), Positives = 51/102 (50%), Gaps = 9/102 (8%)
Query: 340 QGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRG 399
QG P + P + L + W+HGP+SR A L+ +G FLVR+SE+ G
Sbjct: 108 QGWVPSNYITPV-----NSLEKHSWYHGPVSRNAAEYLLS---SGINGSFLVRESESSPG 159
Query: 400 EYVLTFNFQGIAKHLRLSLTERGQCRV-QHLHFPSVVDMLHH 440
+ ++ ++G H R++ G+ V F ++ +++HH
Sbjct: 160 QRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHH 201
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 49.7 bits (117), Expect = 7e-06
Identities = 29/102 (28%), Positives = 51/102 (50%), Gaps = 9/102 (8%)
Query: 340 QGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRG 399
QG P + P + L + W+HGP+SR A L+ +G FLVR+SE+ G
Sbjct: 127 QGWVPSNYITPV-----NSLEKHSWYHGPVSRNAAEYLLS---SGINGSFLVRESESSPG 178
Query: 400 EYVLTFNFQGIAKHLRLSLTERGQCRV-QHLHFPSVVDMLHH 440
+ ++ ++G H R++ G+ V F ++ +++HH
Sbjct: 179 QRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHH 220
>gi|224586793 src homology 2 domain-containing transforming protein
C3 [Homo sapiens]
Length = 594
Score = 49.3 bits (116), Expect = 1e-05
Identities = 31/90 (34%), Positives = 46/90 (51%), Gaps = 6/90 (6%)
Query: 359 LSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSL 418
L W+ G +SR +A L++ G FLVR+S T G +VLT G AKHL L +
Sbjct: 494 LQAETWYQGEMSRKEAEGLLEKDGD-----FLVRKSTTNPGSFVLTGMHNGQAKHL-LLV 547
Query: 419 TERGQCRVQHLHFPSVVDMLHHFQRSPIPL 448
G R + F S+ +++H S +P+
Sbjct: 548 DPEGTIRTKDRVFDSISHLINHHLESSLPI 577
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 49.3 bits (116), Expect = 1e-05
Identities = 23/84 (27%), Positives = 49/84 (58%), Gaps = 3/84 (3%)
Query: 363 PWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERG 422
PW++G ++R +A + +G + G FL+R SE+ ++ ++ QG KH ++ L E
Sbjct: 281 PWYYGKVTRHQAEMALNERGHE--GDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETV 338
Query: 423 QCRVQHLHFPSVVDMLHHFQRSPI 446
C + F ++ +++ H++++PI
Sbjct: 339 YC-IGQRKFSTMEELVEHYKKAPI 361
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 48.9 bits (115), Expect = 1e-05
Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 2/85 (2%)
Query: 359 LSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSL 418
LS PW+ +SR +A QL+ L P+ G FL+R SE+ G Y L+ Q H R+S+
Sbjct: 115 LSDQPWYFSGVSRTQAQQLL-LSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSM 173
Query: 419 TERGQCRVQHLH-FPSVVDMLHHFQ 442
G +Q FP + ++L +++
Sbjct: 174 AADGSLYLQKGRLFPGLEELLTYYK 198
>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
Length = 538
Score = 48.1 bits (113), Expect = 2e-05
Identities = 79/263 (30%), Positives = 104/263 (39%), Gaps = 59/263 (22%)
Query: 4 PALQP----SSPSSAPSASPAAAPRGWSEFC-----ELHAVAAARELARQYWLFAREH-P 53
PAL P ++ ++A +AS +AA + E+ L + A +L R + R H P
Sbjct: 5 PALPPPETAAAATTAAAASSSAASPHYQEWILDTIDSLRSRKARPDLERICRMVRRRHGP 64
Query: 54 QHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAP 113
+ RAEL L + QR R G YR+ R P + A+P P P A
Sbjct: 65 EPERTRAELEKL----IQQRAVLRVSYKGSI---SYRNAARVQPPRRGATP-PAPPRAPR 116
Query: 114 GLPKARSSEEL----APPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEA 169
G P A ++ APP PP P + R+ R AA A AP +PG
Sbjct: 117 GAPAAAAAAAPPPTPAPPPPPAPVAAAAPARAPR-----------AAAAAATAPPSPG-- 163
Query: 170 AETPARPG-LAKKFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAP 228
PA+PG A++ P LA PP A AV A A RRAP
Sbjct: 164 ---PAQPGPRAQRAAP--LAAPPPAPAAPPAV-----APPAGP-------------RRAP 200
Query: 229 GPDGPDRVLELFDPPKSSRPKLQ 251
P R L PP+ P Q
Sbjct: 201 PPAVAAREPPLPPPPQPPAPPQQ 223
Score = 37.0 bits (84), Expect = 0.049
Identities = 32/97 (32%), Positives = 40/97 (41%), Gaps = 18/97 (18%)
Query: 98 AKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAA 157
A A A+ P PGPA PG P+A+ + LA P PP P + A PA
Sbjct: 152 AAAAATAPPSPGPAQPG-PRAQRAAPLAAP-PPAPAA--------------PPAVAPPAG 195
Query: 158 HTAAAPGTPGEAAETPARPGLAKKFLPWSLAREPPPE 194
A P P AA P P + P + PPP+
Sbjct: 196 PRRAPP--PAVAAREPPLPPPPQPPAPPQQQQPPPPQ 230
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,487,731
Number of Sequences: 37866
Number of extensions: 1785691
Number of successful extensions: 15699
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 653
Number of HSP's that attempted gapping in prelim test: 12502
Number of HSP's gapped (non-prelim): 3465
length of query: 575
length of database: 18,247,518
effective HSP length: 108
effective length of query: 467
effective length of database: 14,157,990
effective search space: 6611781330
effective search space used: 6611781330
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.