Search of human proteins with 48762932

Search of human proteins with 48762932

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|48762932 chaperonin containing TCP1, subunit 8 (theta) [Homo
sapiens]
         (548 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|48762932 chaperonin containing TCP1, subunit 8 (theta) [Homo ...  1080   0.0  
gi|7657253 T-complex protein 1 [Homo sapiens]                         269   4e-72
gi|57863257 T-complex protein 1 isoform a [Homo sapiens]              245   7e-65
gi|24307939 chaperonin containing TCP1, subunit 5 (epsilon) [Hom...   244   2e-64
gi|38455427 chaperonin containing TCP1, subunit 4 (delta) [Homo ...   239   6e-63
gi|63162572 chaperonin containing TCP1, subunit 3 isoform a [Hom...   218   9e-57
gi|58761486 chaperonin containing TCP1, subunit 3 isoform b [Hom...   212   6e-55
gi|5453607 chaperonin containing TCP1, subunit 7 isoform a [Homo...   206   3e-53
gi|5453603 chaperonin containing TCP1, subunit 2 [Homo sapiens]       192   5e-49
gi|58761484 chaperonin containing TCP1, subunit 3 isoform c [Hom...   182   5e-46
gi|4502643 chaperonin containing TCP1, subunit 6A isoform a [Hom...   176   5e-44
gi|58331173 chaperonin containing TCP1, subunit 6B [Homo sapiens]     173   4e-43
gi|57863259 T-complex protein 1 isoform b [Homo sapiens]              154   2e-37
gi|58331171 chaperonin containing TCP1, subunit 6A isoform b [Ho...   129   9e-30
gi|58331185 chaperonin containing TCP1, subunit 7 isoform b [Hom...   119   7e-27
gi|9055272 McKusick-Kaufman syndrome protein [Homo sapiens]            47   3e-05
gi|25914754 McKusick-Kaufman syndrome protein [Homo sapiens]           47   3e-05
gi|41399285 chaperonin [Homo sapiens]                                  40   0.004
gi|31542947 chaperonin [Homo sapiens]                                  40   0.004
gi|100816407 Bardet-Biedl syndrome 10 [Homo sapiens]                   39   0.012
gi|40217788 Bardet-Biedl syndrome 12 [Homo sapiens]                    37   0.061
gi|12738834 PRAME family member 2 [Homo sapiens]                       35   0.18 
gi|226246537 zinc finger protein 407 isoform 3 [Homo sapiens]          35   0.23 
gi|226246535 zinc finger protein 407 isoform 2 [Homo sapiens]          35   0.23 
gi|134133288 zinc finger protein 407 isoform 1 [Homo sapiens]          35   0.23 
gi|22547221 tolloid-like 1 [Homo sapiens]                              34   0.30 
gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens]         32   1.5  

>gi|48762932 chaperonin containing TCP1, subunit 8 (theta) [Homo
           sapiens]
          Length = 548

 Score = 1080 bits (2792), Expect = 0.0
 Identities = 548/548 (100%), Positives = 548/548 (100%)

Query: 1   MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHL 60
           MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHL
Sbjct: 1   MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHL 60

Query: 61  EKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLR 120
           EKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLR
Sbjct: 61  EKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLR 120

Query: 121 IGLSVSEVIEGYEIACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLA 180
           IGLSVSEVIEGYEIACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLA
Sbjct: 121 IGLSVSEVIEGYEIACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLA 180

Query: 181 KLIAQACVSIFPDSGHFNVDNIRVCKILGSGISSSSVLHGMVFKKETEGDVTSVKDAKIA 240
           KLIAQACVSIFPDSGHFNVDNIRVCKILGSGISSSSVLHGMVFKKETEGDVTSVKDAKIA
Sbjct: 181 KLIAQACVSIFPDSGHFNVDNIRVCKILGSGISSSSVLHGMVFKKETEGDVTSVKDAKIA 240

Query: 241 VYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADM 300
           VYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADM
Sbjct: 241 VYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADM 300

Query: 301 ALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQV 360
           ALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQV
Sbjct: 301 ALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQV 360

Query: 361 VVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELA 420
           VVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELA
Sbjct: 361 VVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELA 420

Query: 421 KQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGL 480
           KQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGL
Sbjct: 421 KQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGL 480

Query: 481 DIEAEVPAVKDMLEAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKK 540
           DIEAEVPAVKDMLEAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKK
Sbjct: 481 DIEAEVPAVKDMLEAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKK 540

Query: 541 DWDDDQND 548
           DWDDDQND
Sbjct: 541 DWDDDQND 548


>gi|7657253 T-complex protein 1 [Homo sapiens]
          Length = 557

 Score =  269 bits (688), Expect = 4e-72
 Identities = 169/522 (32%), Positives = 273/522 (52%), Gaps = 17/522 (3%)

Query: 26  EEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKM 85
           E  +  ++ A + LA   R  YGP+G  K ++    +   T  A  ILR LE++HPAA +
Sbjct: 30  EPHLLSSLAAVQTLASVIRPCYGPHGRQKFLVTMKGETVCTGCATAILRALELEHPAAWL 89

Query: 86  IVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPN 145
           +  A   Q +  GDGT FV++   ALLE AE+LL+ GL   ++ E Y  A  +    LP+
Sbjct: 90  LREAGQTQAENSGDGTAFVVLLTEALLEQAEQLLKAGLPRPQLREAYATATAEVLATLPS 149

Query: 146 LVCCSAKNLRDID-EVSSLLRTSIMSKQYGNEVFLAKLIAQACVSIFPDSGHFNVDNIRV 204
           L   S   L D    + S++ T  +S        L KL+A AC +I    G F  + + V
Sbjct: 150 LAIQSLGPLEDPSWALHSVMNTHTLSPMD----HLTKLVAHACWAIKELDGSFKPERVGV 205

Query: 205 CKILGSGISSSSVLHGMVFKKETEGDVTSV-KDAKIAVYSCPFDGMITETKGTVLIKTAE 263
           C + G  +  S +L G+    +  G + +V   A++A+++CPF         T  + +  
Sbjct: 206 CALPGGTLEDSCLLPGLAISGKLCGQMATVLSGARVALFACPFGPAHPNAPATARLSSPA 265

Query: 264 ELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMALHYANKYNIMLVRLNSKWDLRR 323
           +L  FSKG + L++ QV  +A  G NV V  G+V +  L  A+KY I++++  S  ++  
Sbjct: 266 DLAQFSKGSDQLLEKQVGQLAAAGINVAVVLGEVDEETLTLADKYGIVVIQARSWMEIIY 325

Query: 324 LCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDN 383
           L + +    LPRL PP  +  G C  VY  E+GD   VVF+ E       T+VLRG+T  
Sbjct: 326 LSEVLDTPLLPRLLPP--QRPGKCQRVYRQELGDGLAVVFEWECTGTPALTVVLRGATTQ 383

Query: 384 LMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAE 443
            +   E+AV  G++ +  L +D RL+PG GATE+ LAK ++  G    G    A   FA 
Sbjct: 384 GLRSAEQAVYHGIDAYFQLCQDPRLIPGAGATEMALAKMLSDKGSRLEGPSGPAFLAFAW 443

Query: 444 AFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGILDTYLG 503
           A + +P+ LAEN+G+  ++V++++  VHQ GN  +G+  E     + ++ + G+ DT + 
Sbjct: 444 ALKYLPKTLAENAGLAVSDVMAEMSGVHQGGNLLMGVGTE----GIINVAQEGVWDTLIV 499

Query: 504 KYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKDWDDD 545
           K    +      + ++ VD+I++AK     K P+ ++ W+ D
Sbjct: 500 KAQGFRAVAEVVLQLVTVDEIVVAK-----KSPTHQEIWNPD 536


>gi|57863257 T-complex protein 1 isoform a [Homo sapiens]
          Length = 556

 Score =  245 bits (626), Expect = 7e-65
 Identities = 163/521 (31%), Positives = 277/521 (53%), Gaps = 27/521 (5%)

Query: 31  RNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMAS 90
           +N+ A   +A   +++ GP G++KM+++ +  + +TND ATIL+ LEV+HPAAK++   +
Sbjct: 20  QNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKVLCELA 79

Query: 91  HMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKA-HEILPNLVCC 149
            +Q++EVGDGT  V++ A  LL+ A+EL++  +  + VI GY +AC++A   I  NL+  
Sbjct: 80  DLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRYINENLIVN 139

Query: 150 SAKNLRDIDEVSSLLRTSIMSKQYG-NEVFLAKLIAQACVSI----FPDSGHFNVDNIRV 204
           + +  RD   + +  +TS+ SK  G N  F A ++  A ++I          + V+++ +
Sbjct: 140 TDELGRDC--LINAAKTSMSSKIIGINGDFFANMVVDAVLAIKYTDIRGQPRYPVNSVNI 197

Query: 205 CKILGSGISSSSVLHGMVFK--KETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTA 262
            K  G     S ++ G        ++G    + +AKIA           +    V+I   
Sbjct: 198 LKAHGRSQMESMLISGYALNCVVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQVVITDP 257

Query: 263 EELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMALHYANKYNIMLVRLNSKWDLR 322
           E+L    + E ++   +++ I  TGANV++T G + DM L Y  +   M VR   K DL+
Sbjct: 258 EKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLK 317

Query: 323 RLCKTVGATALPRLTPPVLEE------MGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIV 376
           R+ K  GAT L  L     EE      +G  + V    + D ++++ K+ K   + S I+
Sbjct: 318 RIAKASGATILSTLANLEGEETFEAAMLGQAEEVVQERICDDELILIKNTKARTSAS-II 376

Query: 377 LRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQY 436
           LRG+ D + D++ER++ D +   K +   K +VPGGGA E  L+  + +Y  +    EQ 
Sbjct: 377 LRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQL 436

Query: 437 AIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKN--------VGLDIEAEVPA 488
           AI +FA +   IP  LA N+   + ++++KL A H E   N        +GLD+    P 
Sbjct: 437 AIAEFARSLLVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLSNGKP- 495

Query: 489 VKDMLEAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKP 529
            +D  +AG+ +  + K  ++K AT AA+T+LR+D +I   P
Sbjct: 496 -RDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIKLHP 535


>gi|24307939 chaperonin containing TCP1, subunit 5 (epsilon) [Homo
           sapiens]
          Length = 541

 Score =  244 bits (622), Expect = 2e-64
 Identities = 161/504 (31%), Positives = 265/504 (52%), Gaps = 8/504 (1%)

Query: 27  EAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMI 86
           EA+  +I A K +A T RT+ GPNG++KM+++    + VTND ATIL  ++V H  AK++
Sbjct: 32  EALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLM 91

Query: 87  VMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPNL 146
           V  S  Q+ E+GDGT  V+V AGALLE AE+LL  G+    + +GYE A R A E L  +
Sbjct: 92  VELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKI 151

Query: 147 VCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLAKLIAQACVSIFPDSGHFNVD--NIRV 204
                 +++D + +    +T++ SK   +       IA   V    D    +VD   I+V
Sbjct: 152 SDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKV 211

Query: 205 CKILGSGISSSSVLHGMVFKKETEGD--VTSVKDAKIAVYSCPFDGMITETKGTVLIKTA 262
              +G  +  + ++ G++  K+         V+DAKIA+ +CPF+    +TK  + + + 
Sbjct: 212 EGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSV 271

Query: 263 EELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMALHYANKYNIMLVRLNSKWDLR 322
           E+     K E+   +  ++ I +TGAN+ +      D A H   + N+  VR     ++ 
Sbjct: 272 EDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIE 331

Query: 323 RLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDT--QVVVFKHEKEDGAISTIVLRGS 380
            +    G   +PR +    E++G    V     G T  +++V +  K   A+ TI +RG 
Sbjct: 332 LIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAV-TIFIRGG 390

Query: 381 TDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKK 440
              ++++ +R++ D +   + L RD R+V GGGA EI  A  ++   + CP LEQYA++ 
Sbjct: 391 NKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRA 450

Query: 441 FAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGILDT 500
           FA+A E IP AL+ENSG+   + ++++ A  Q    N  L I+       DM +  +++T
Sbjct: 451 FADALEVIPMALSENSGMNPIQTMTEVRA-RQVKEMNPALGIDCLHKGTNDMKQQHVIET 509

Query: 501 YLGKYWAIKLATNAAVTVLRVDQI 524
            +GK   I LAT     +L++D I
Sbjct: 510 LIGKKQQISLATQMVRMILKIDDI 533


>gi|38455427 chaperonin containing TCP1, subunit 4 (delta) [Homo
           sapiens]
          Length = 539

 Score =  239 bits (609), Expect = 6e-63
 Identities = 149/508 (29%), Positives = 270/508 (53%), Gaps = 18/508 (3%)

Query: 30  YRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMA 89
           + NI A K +A   RT+ GP GM+KM+ +    + +TND ATIL++++V HPAA+M+V  
Sbjct: 35  FSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVEL 94

Query: 90  SHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPNLVCC 149
           S  Q+ E GDGT  V++ AG+LL+   +LL+ G+  + + E ++ A  K  EIL ++   
Sbjct: 95  SKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDM--S 152

Query: 150 SAKNLRDIDEVSSLLRTSIMSK---QYGNEVFLAKLIAQACVSIFPDSGHFNVD--NIRV 204
               L D + + +   TS+ SK   QY +   L+ +   A + +   +   +VD  +I++
Sbjct: 153 RPVELSDRETLLNSATTSLNSKVVSQYSS--LLSPMSVNAVMKVIDPATATSVDLRDIKI 210

Query: 205 CKILGSGISSSSVLHGMVF-KKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTAE 263
            K LG  I    ++ G+V  +K +   +T V+ AKI +         T+    +++    
Sbjct: 211 VKKLGGTIDDCELVEGLVLTQKVSNSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYA 270

Query: 264 ELMNFSKGEENLMDAQVKAIADTGANVV-----VTGGKVADMALHYANKYNIMLVRLNSK 318
           ++    + E   +   VK I  TG NV+     +    ++D+ALH+ NK  IM+++   +
Sbjct: 271 QMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVIKDIER 330

Query: 319 WDLRRLCKTVGATALPRLTPPVLEEMGHCD-SVYLSEVGDTQVVVFKHEKEDGAISTIVL 377
            D+  +CKT+G   +  +     + +G  + +  ++  G  +++        G   TIV+
Sbjct: 331 EDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEVNLNGSGKLLKITGCASPGKTVTIVV 390

Query: 378 RGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYA 437
           RGS   ++++ ER++ D +   + L + + L+ GGGA EIELA ++T Y  T  G+E Y 
Sbjct: 391 RGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYC 450

Query: 438 IKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGI 497
           ++ FA+A E IP  LAEN+G+     +++L   H +G K  G+++      + ++LE  +
Sbjct: 451 VRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRK--GGISNILEELV 508

Query: 498 LDTYLGKYWAIKLATNAAVTVLRVDQII 525
           +   L    A+ LAT    ++L++D ++
Sbjct: 509 VQPLLVSVSALTLATETVRSILKIDDVV 536


>gi|63162572 chaperonin containing TCP1, subunit 3 isoform a [Homo
           sapiens]
          Length = 545

 Score =  218 bits (556), Expect = 9e-57
 Identities = 162/546 (29%), Positives = 264/546 (48%), Gaps = 32/546 (5%)

Query: 14  MLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATIL 73
           +L +  K  SG  +    NI A K +A   RT  GP  M KM+++ +  + +TND   IL
Sbjct: 9   VLSQNTKRESG-RKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAIL 67

Query: 74  RELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYE 133
           RE++VQHPAAK ++  S  Q++EVGDGT  V++ AG +L +AE  L   +  + VI  Y 
Sbjct: 68  REIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYR 127

Query: 134 IACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLAKLIAQACVSI--F 191
            A       L  +      ++ D D + +++ +SI +K       LA  IA   V +  F
Sbjct: 128 KALDDMISTLKKI--SIPVDISDSDMMLNIINSSITTKAISRWSSLACNIALDAVKMVQF 185

Query: 192 PDSGHFNVD---NIRVCKILGSGISSSSVLHGMVFKKETEGDVTS------VKDAKIAVY 242
            ++G   +D     RV KI G  I  S VL G++  K    DVT       +K+ +I + 
Sbjct: 186 EENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINK----DVTHPRMRRYIKNPRIVLL 241

Query: 243 SCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMAL 302
               +    E++  + I   E+     + EE  +    + I     +VV+T   ++D+A 
Sbjct: 242 DSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQ 301

Query: 303 HYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMG-HCDSVYLSEVGDTQVV 361
           HY  + NI  +R   K D  R+ +  GA  + R      +++G     + + ++GD +  
Sbjct: 302 HYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGD-EYF 360

Query: 362 VFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAK 421
            F  + +D    TI+LRG++  ++ ++ER + D +   + +  D +LVPGGGA+E+ +A 
Sbjct: 361 TFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAH 420

Query: 422 QITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLD 481
            +T   +   G+EQ+  +  A+A E IPR L +N G     +++ L A H + N      
Sbjct: 421 ALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCET-WG 479

Query: 482 IEAEVPAVKDMLEAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKD 541
           +  E   + DM E GI +    K    K A   AV +LR+D I+           SG K 
Sbjct: 480 VNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIV-----------SGHKK 528

Query: 542 WDDDQN 547
             DDQ+
Sbjct: 529 KGDDQS 534


>gi|58761486 chaperonin containing TCP1, subunit 3 isoform b [Homo
           sapiens]
          Length = 544

 Score =  212 bits (540), Expect = 6e-55
 Identities = 161/546 (29%), Positives = 263/546 (48%), Gaps = 33/546 (6%)

Query: 14  MLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATIL 73
           +L +  K  SG  +    NI A K +A   RT  GP  M KM+++ +  + +TND   IL
Sbjct: 9   VLSQNTKRESG-RKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAIL 67

Query: 74  RELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYE 133
           RE++VQHPAAK ++  S  Q++EVGDGT  V++  G +L +AE  L   +  + VI  Y 
Sbjct: 68  REIQVQHPAAKSMIEISRTQDEEVGDGTTSVIIL-GEMLSVAEHFLEQQMHPTVVISAYR 126

Query: 134 IACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLAKLIAQACVSI--F 191
            A       L  +      ++ D D + +++ +SI +K       LA  IA   V +  F
Sbjct: 127 KALDDMISTLKKISI--PVDISDSDMMLNIINSSITTKAISRWSSLACNIALDAVKMVQF 184

Query: 192 PDSGHFNVD---NIRVCKILGSGISSSSVLHGMVFKKETEGDVTS------VKDAKIAVY 242
            ++G   +D     RV KI G  I  S VL G++  K    DVT       +K+ +I + 
Sbjct: 185 EENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINK----DVTHPRMRRYIKNPRIVLL 240

Query: 243 SCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMAL 302
               +    E++  + I   E+     + EE  +    + I     +VV+T   ++D+A 
Sbjct: 241 DSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQ 300

Query: 303 HYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGH-CDSVYLSEVGDTQVV 361
           HY  + NI  +R   K D  R+ +  GA  + R      +++G     + + ++GD +  
Sbjct: 301 HYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGD-EYF 359

Query: 362 VFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAK 421
            F  + +D    TI+LRG++  ++ ++ER + D +   + +  D +LVPGGGA+E+ +A 
Sbjct: 360 TFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAH 419

Query: 422 QITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLD 481
            +T   +   G+EQ+  +  A+A E IPR L +N G     +++ L A H + N      
Sbjct: 420 ALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCET-WG 478

Query: 482 IEAEVPAVKDMLEAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKD 541
           +  E   + DM E GI +    K    K A   AV +LR+D I+           SG K 
Sbjct: 479 VNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIV-----------SGHKK 527

Query: 542 WDDDQN 547
             DDQ+
Sbjct: 528 KGDDQS 533


>gi|5453607 chaperonin containing TCP1, subunit 7 isoform a [Homo
           sapiens]
          Length = 543

 Score =  206 bits (525), Expect = 3e-53
 Identities = 143/523 (27%), Positives = 254/523 (48%), Gaps = 21/523 (4%)

Query: 14  MLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATIL 73
           +LKEG     G+ + V  NI AC+ +A+  RT  GP GM+K++++   K  ++ND ATIL
Sbjct: 8   LLKEGTDSSQGIPQLV-SNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATIL 66

Query: 74  RELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGY- 132
           + L+V HPAAK +V  +  Q+ EVGDGT  V + A   L+  +  +  GL    +I  + 
Sbjct: 67  KLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFR 126

Query: 133 ---EIACRKAHEILPNLVCCSAKNLRDIDEVSSL--LRTSIMSKQYGNEVFLAKLIAQAC 187
              ++A  K  EI   +        R + E  ++  L + ++S+Q   + F AK++  A 
Sbjct: 127 TATQLAVNKIKEIAVTVKKADKVEQRKLLEKCAMTALSSKLISQQ---KAFFAKMVVDAV 183

Query: 188 VSIFPDSGHFNVDNIRVCKILGSGISSSSVLHGMVFKKET-----EGDVTSVKDAKIAVY 242
           + +        +  I + K+ G  +  S ++ G+ FKK       E       + KIA+ 
Sbjct: 184 MML---DDLLQLKMIGIKKVQGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALL 240

Query: 243 SCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMAL 302
           +   +    +    + + T E+       E N++  +++ I  +GA VV++   + D+A 
Sbjct: 241 NVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVAT 300

Query: 303 HYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVV 362
            Y    ++       + DL+R     G +    +     + +G C     +++G  +   
Sbjct: 301 QYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGRCQVFEETQIGGERYNF 360

Query: 363 FKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQ 422
           F    +     T +LRG  +  M++ ER++ D +   +   ++  +V GGGA E+EL+K 
Sbjct: 361 FTGCPK-AKTCTFILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKY 419

Query: 423 ITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDI 482
           +  Y  T PG +Q  I  +A+A E IPR L +N+G  A  +++KL A H +G    G+DI
Sbjct: 420 LRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGTWYGVDI 479

Query: 483 EAEVPAVKDMLEAGILDTYLGKYWAIKLATNAAVTVLRVDQII 525
             E   + D  EA + +  + +  A+  A+ AA  ++ VD+ I
Sbjct: 480 NNE--DIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETI 520


>gi|5453603 chaperonin containing TCP1, subunit 2 [Homo sapiens]
          Length = 535

 Score =  192 bits (489), Expect = 5e-49
 Identities = 137/497 (27%), Positives = 240/497 (48%), Gaps = 12/497 (2%)

Query: 39  LAQTTRTAYGPNGMNKMVINHLE--KLFVTNDAATILRELEVQHPAAKMIVMASHMQEQE 96
           +    ++  GP GM+K++++      L VTND ATIL+ + V +PAAK++V  S +Q+ E
Sbjct: 35  IGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDE 94

Query: 97  VGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHE-ILPNLVCCSAKNLR 155
           VGDGT  V V A  LL  AE L+   +    +I G+  A + A E +L + V   +  ++
Sbjct: 95  VGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAAREALLSSAVDHGSDEVK 154

Query: 156 DIDEVSSLLRTSIMSKQYGNEV-FLAKLIAQACVSIFPDSGHFNVDNIRVCKILGSGISS 214
              ++ ++  T++ SK   +      KL  +A + +    G  N++ I + K LG  ++ 
Sbjct: 155 FRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRL---KGSGNLEAIHIIKKLGGSLAD 211

Query: 215 SSVLHGMVF-KKETEGDVTSVKDAKIAVYSCPFDGMITETKGT-VLIKTAEELMNFSKGE 272
           S +  G +  KK        +++AKI + +   D    +  G+ V + +  ++      E
Sbjct: 212 SYLDEGFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAE 271

Query: 273 ENLMDAQVKAIADTGANVVVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATA 332
           +  M  +V+ I   G N  +    + +          +M +       + RL    G   
Sbjct: 272 KEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEI 331

Query: 333 LPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAV 392
                 P L ++G C  +    +G+ +++ F      G   TIVLRG+T  ++D+ ER++
Sbjct: 332 ASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVAL-GEACTIVLRGATQQILDEAERSL 390

Query: 393 DDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRAL 452
            D +       +D R V GGG +E+ +A  +T      PG E  A++ +A+A   +P  +
Sbjct: 391 HDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEAVAMESYAKALRMLPTII 450

Query: 453 AENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGILDTYLGKYWAIKLAT 512
           A+N+G  + +++++L A H EGN   GLD+      + DM   GI +++  K   +  A 
Sbjct: 451 ADNAGYDSADLVAQLRAAHSEGNTTAGLDMRE--GTIGDMAILGITESFQVKRQVLLSAA 508

Query: 513 NAAVTVLRVDQIIMAKP 529
            AA  +LRVD II A P
Sbjct: 509 EAAEVILRVDNIIKAAP 525


>gi|58761484 chaperonin containing TCP1, subunit 3 isoform c [Homo
           sapiens]
          Length = 507

 Score =  182 bits (463), Expect = 5e-46
 Identities = 139/485 (28%), Positives = 232/485 (47%), Gaps = 31/485 (6%)

Query: 75  ELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEI 134
           +++VQHPAAK ++  S  Q++EVGDGT  V++ AG +L +AE  L   +  + VI  Y  
Sbjct: 31  KIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRK 90

Query: 135 ACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLAKLIAQACVSI--FP 192
           A       L  +      ++ D D + +++ +SI +K       LA  IA   V +  F 
Sbjct: 91  ALDDMISTLKKISI--PVDISDSDMMLNIINSSITTKAISRWSSLACNIALDAVKMVQFE 148

Query: 193 DSGHFNVD---NIRVCKILGSGISSSSVLHGMVFKKETEGDVTS------VKDAKIAVYS 243
           ++G   +D     RV KI G  I  S VL G++  K    DVT       +K+ +I +  
Sbjct: 149 ENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINK----DVTHPRMRRYIKNPRIVLLD 204

Query: 244 CPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMALH 303
              +    E++  + I   E+     + EE  +    + I     +VV+T   ++D+A H
Sbjct: 205 SSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQH 264

Query: 304 YANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGH-CDSVYLSEVGDTQVVV 362
           Y  + NI  +R   K D  R+ +  GA  + R      +++G     + + ++GD +   
Sbjct: 265 YLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGD-EYFT 323

Query: 363 FKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQ 422
           F  + +D    TI+LRG++  ++ ++ER + D +   + +  D +LVPGGGA+E+ +A  
Sbjct: 324 FITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHA 383

Query: 423 ITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDI 482
           +T   +   G+EQ+  +  A+A E IPR L +N G     +++ L A H + N      +
Sbjct: 384 LTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCET-WGV 442

Query: 483 EAEVPAVKDMLEAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKDW 542
             E   + DM E GI +    K    K A   AV +LR+D I+           SG K  
Sbjct: 443 NGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIV-----------SGHKKK 491

Query: 543 DDDQN 547
            DDQ+
Sbjct: 492 GDDQS 496


>gi|4502643 chaperonin containing TCP1, subunit 6A isoform a [Homo
           sapiens]
          Length = 531

 Score =  176 bits (446), Expect = 5e-44
 Identities = 134/514 (26%), Positives = 232/514 (45%), Gaps = 18/514 (3%)

Query: 26  EEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKM 85
           + A+  NI A + L    RT  GP G  KM+++    + +T D   +L E+++QHP A +
Sbjct: 17  QAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASL 76

Query: 86  IVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPN 145
           I   +  Q+   GDGT   ++  G LL+ A+  +  GL    + EG+E A  KA + L  
Sbjct: 77  IAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEE 136

Query: 146 LVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEV-FLAKLIAQACVSIFPDSGHFNVDNIRV 204
           +         D + +  + RTS+ +K +      L + +  + ++I       ++  I +
Sbjct: 137 V---KVSREMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEPIDLFMIEI 193

Query: 205 CKILGSGISSSSVLHGMVFKKETEGDVTS--VKDAKIAVYSCPFDGMITETKGTVLIKTA 262
            ++     + +S++ G+V             V+DA I   +   +   TE       K+A
Sbjct: 194 MEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSA 253

Query: 263 EELMNFSKGEENLMDAQVKAI--------ADTGANVVVTGGKVAD-MALHYANKYNIMLV 313
           EE     K E   ++ +VK I         D+    VV   K  D  +L   +K  I+ +
Sbjct: 254 EEREKLVKAERKFIEDRVKKIIELKRKVCGDSDKGFVVINQKGIDPFSLDALSKEGIVAL 313

Query: 314 RLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAIS 373
           R   + ++ RL    G  AL        + +GH   VY   +G+ +    +      ++ 
Sbjct: 314 RRAKRRNMERLTLACGGVALNSFDDLSPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSV- 372

Query: 374 TIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGL 433
           T++++G   + +  I+ AV DG+   K    D  +VPG GA E+ +A+ +  +  +  G 
Sbjct: 373 TLLIKGPNKHTLTQIKDAVRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALIKHKPSVKGR 432

Query: 434 EQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDML 493
            Q  ++ FA+A   IP+ LA+NSG    E + K+ A H E  + VG+D+    P V    
Sbjct: 433 AQLGVQAFADALLIIPKVLAQNSGFDLQETLVKIQAEHSESGQLVGVDLNTGEPMV--AA 490

Query: 494 EAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMA 527
           E G+ D Y  K   +   T  A  +L VD+I+ A
Sbjct: 491 EVGVWDNYCVKKQLLHSCTVIATNILLVDEIMRA 524


>gi|58331173 chaperonin containing TCP1, subunit 6B [Homo sapiens]
          Length = 530

 Score =  173 bits (438), Expect = 4e-43
 Identities = 127/508 (25%), Positives = 233/508 (45%), Gaps = 18/508 (3%)

Query: 32  NIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASH 91
           NI A + L    RT  GP G  KM+++    + +T D   +L E+++QHP A +I   + 
Sbjct: 23  NICAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLDEMQIQHPTASLIAKVAT 82

Query: 92  MQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPNLVCCSA 151
            Q+   GDGT   ++  G LL+ A+  +  GL    + EG+E A  KA E+L  +     
Sbjct: 83  AQDDVTGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEAAKIKALEVLEEVKVTKE 142

Query: 152 KNLRDIDEVSSLLRTSIMSKQYGNEV-FLAKLIAQACVSIFPDSGHFNVDNIRVCKILGS 210
              + + +V+   RTS+ +K +      L +++  + +++       ++  + + ++   
Sbjct: 143 MKRKILLDVA---RTSLQTKVHAELADVLTEVVVDSVLAVRRPGYPIDLFMVEIMEMKHK 199

Query: 211 GISSSSVLHGMVFKKETEGDVTS--VKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNF 268
             + + ++ G+V             V+DA I + +   +   TE       KTAEE    
Sbjct: 200 LGTDTKLIQGLVLDHGARHPDMKKRVEDAFILICNVSLEYEKTEVNSGFFYKTAEEKEKL 259

Query: 269 SKGEENLMDAQVKAIADTGANVVVTGGK---------VADMALHYANKYNIMLVRLNSKW 319
            K E   ++ +V+ I D    V     K         +   +L    K+ I+ +R   + 
Sbjct: 260 VKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDSLAKHGIVALRRAKRR 319

Query: 320 DLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRG 379
           ++ RL    G  A+       ++ +GH   VY   +G+ +   F  E  +    T++++G
Sbjct: 320 NMERLSLACGGMAVNSFEDLTVDCLGHAGLVYEYTLGEEKFT-FIEECVNPCSVTLLVKG 378

Query: 380 STDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIK 439
              + +  ++ A+ DG+   K    D  +VPG GA E+ +A+ + +Y  +  G  +  ++
Sbjct: 379 PNKHTLTQVKDAIRDGLRAIKNAIEDGCMVPGAGAIEVAMAEALVTYKNSIKGRARLGVQ 438

Query: 440 KFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGILD 499
            FA+A   IP+ LA+N+G    E + K+ A H E  + VG+D+    P V    +AG+ D
Sbjct: 439 AFADALLIIPKVLAQNAGYDPQETLVKVQAEHVESKQLVGVDLNTGEPMV--AADAGVWD 496

Query: 500 TYLGKYWAIKLATNAAVTVLRVDQIIMA 527
            Y  K   +   T  A  +L VD+I+ A
Sbjct: 497 NYCVKKQLLHSCTVIATNILLVDEIMRA 524


>gi|57863259 T-complex protein 1 isoform b [Homo sapiens]
          Length = 401

 Score =  154 bits (390), Expect = 2e-37
 Identities = 109/375 (29%), Positives = 183/375 (48%), Gaps = 23/375 (6%)

Query: 175 NEVFLAKLIAQACVSI----FPDSGHFNVDNIRVCKILGSGISSSSVLHGMVFK--KETE 228
           N  F A ++  A ++I          + V+++ + K  G     S ++ G        ++
Sbjct: 9   NGDFFANMVVDAVLAIKYTDIRGQPRYPVNSVNILKAHGRSQMESMLISGYALNCVVGSQ 68

Query: 229 GDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGA 288
           G    + +AKIA           +    V+I   E+L    + E ++   +++ I  TGA
Sbjct: 69  GMPKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGA 128

Query: 289 NVVVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEE----- 343
           NV++T G + DM L Y  +   M VR   K DL+R+ K  GAT L  L     EE     
Sbjct: 129 NVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGATILSTLANLEGEETFEAA 188

Query: 344 -MGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVL 402
            +G  + V    + D ++++ K+ K   + S I+LRG+ D + D++ER++ D +   K +
Sbjct: 189 MLGQAEEVVQERICDDELILIKNTKARTSAS-IILRGANDFMCDEMERSLHDALCVVKRV 247

Query: 403 TRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANE 462
              K +VPGGGA E  L+  + +Y  +    EQ AI +FA +   IP  LA N+   + +
Sbjct: 248 LESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPNTLAVNAAQDSTD 307

Query: 463 VISKLYAVHQEGNKN--------VGLDIEAEVPAVKDMLEAGILDTYLGKYWAIKLATNA 514
           +++KL A H E   N        +GLD+    P  +D  +AG+ +  + K  ++K AT A
Sbjct: 308 LVAKLRAFHNEAQVNPERKNLKWIGLDLSNGKP--RDNKQAGVFEPTIVKVKSLKFATEA 365

Query: 515 AVTVLRVDQIIMAKP 529
           A+T+LR+D +I   P
Sbjct: 366 AITILRIDDLIKLHP 380


>gi|58331171 chaperonin containing TCP1, subunit 6A isoform b [Homo
           sapiens]
          Length = 486

 Score =  129 bits (323), Expect = 9e-30
 Identities = 120/514 (23%), Positives = 208/514 (40%), Gaps = 63/514 (12%)

Query: 26  EEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKM 85
           + A+  NI A + L    RT  GP G  KM+++    + +T D   +L E+         
Sbjct: 17  QAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEM--------- 67

Query: 86  IVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPN 145
                                               GL    + EG+E A  KA + L  
Sbjct: 68  ------------------------------------GLHPRIITEGFEAAKEKALQFLEE 91

Query: 146 LVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEV-FLAKLIAQACVSIFPDSGHFNVDNIRV 204
           +         D + +  + RTS+ +K +      L + +  + ++I       ++  I +
Sbjct: 92  V---KVSREMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEPIDLFMIEI 148

Query: 205 CKILGSGISSSSVLHGMVFKKETEGDVTS--VKDAKIAVYSCPFDGMITETKGTVLIKTA 262
            ++     + +S++ G+V             V+DA I   +   +   TE       K+A
Sbjct: 149 MEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSA 208

Query: 263 EELMNFSKGEENLMDAQVKAI--------ADTGANVVVTGGKVAD-MALHYANKYNIMLV 313
           EE     K E   ++ +VK I         D+    VV   K  D  +L   +K  I+ +
Sbjct: 209 EEREKLVKAERKFIEDRVKKIIELKRKVCGDSDKGFVVINQKGIDPFSLDALSKEGIVAL 268

Query: 314 RLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAIS 373
           R   + ++ RL    G  AL        + +GH   VY   +G+ +    +      ++ 
Sbjct: 269 RRAKRRNMERLTLACGGVALNSFDDLSPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSV- 327

Query: 374 TIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGL 433
           T++++G   + +  I+ AV DG+   K    D  +VPG GA E+ +A+ +  +  +  G 
Sbjct: 328 TLLIKGPNKHTLTQIKDAVRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALIKHKPSVKGR 387

Query: 434 EQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDML 493
            Q  ++ FA+A   IP+ LA+NSG    E + K+ A H E  + VG+D+    P V    
Sbjct: 388 AQLGVQAFADALLIIPKVLAQNSGFDLQETLVKIQAEHSESGQLVGVDLNTGEPMV--AA 445

Query: 494 EAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMA 527
           E G+ D Y  K   +   T  A  +L VD+I+ A
Sbjct: 446 EVGVWDNYCVKKQLLHSCTVIATNILLVDEIMRA 479


>gi|58331185 chaperonin containing TCP1, subunit 7 isoform b [Homo
           sapiens]
          Length = 339

 Score =  119 bits (298), Expect = 7e-27
 Identities = 81/316 (25%), Positives = 149/316 (47%), Gaps = 8/316 (2%)

Query: 215 SSVLHGMVFKKET-----EGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNFS 269
           S ++ G+ FKK       E       + KIA+ +   +    +    + + T E+     
Sbjct: 4   SQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEKDNAEIRVHTVEDYQAIV 63

Query: 270 KGEENLMDAQVKAIADTGANVVVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLCKTVG 329
             E N++  +++ I  +GA VV++   + D+A  Y    ++       + DL+R     G
Sbjct: 64  DAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACG 123

Query: 330 ATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIE 389
            +    +     + +G C     +++G  +   F    +     T +LRG  +  M++ E
Sbjct: 124 GSIQTSVNALSADVLGRCQVFEETQIGGERYNFFTGCPK-AKTCTFILRGGAEQFMEETE 182

Query: 390 RAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIP 449
           R++ D +   +   ++  +V GGGA E+EL+K +  Y  T PG +Q  I  +A+A E IP
Sbjct: 183 RSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIP 242

Query: 450 RALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGILDTYLGKYWAIK 509
           R L +N+G  A  +++KL A H +G    G+DI  E   + D  EA + +  + +  A+ 
Sbjct: 243 RQLCDNAGFDATNILNKLRARHAQGGTWYGVDINNE--DIADNFEAFVWEPAMVRINALT 300

Query: 510 LATNAAVTVLRVDQII 525
            A+ AA  ++ VD+ I
Sbjct: 301 AASEAACLIVSVDETI 316


>gi|9055272 McKusick-Kaufman syndrome protein [Homo sapiens]
          Length = 570

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 84/446 (18%), Positives = 168/446 (37%), Gaps = 35/446 (7%)

Query: 39  LAQTTRTAYGPNGMNKMVINHLEK-LFVTNDAATILRELEVQHPAAKMIVMASHMQEQEV 97
           L +   + YGP+G  K + N     +  T+ ++ +L  L V HP  K++  +        
Sbjct: 29  LKRIVTSCYGPSGRLKQLHNGFGGYVCTTSQSSALLSHLLVTHPILKILTASIQNHVSSF 88

Query: 98  GDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPNLVC-CSAK-NLR 155
            D   F  +       L E + R+GL+ + VI   +         L +  C C    +  
Sbjct: 89  SDCGLFTAILC---CNLIENVQRLGLTPTTVIRLNKHLLSLCISYLKSETCGCRIPVDFS 145

Query: 156 DIDEVSSLLRTSIMSK-----QYGNEVFLAKLIAQACVSIFPDS--GHFNVDNIRVCKIL 208
               +  L+R+ + SK            ++ LI +A +   P++  GH  +    +  + 
Sbjct: 146 STQILLCLVRSILTSKPACMLTRKETEHVSALILRAFLLTIPENAEGHIILGKSLIVPLK 205

Query: 209 GSGISSSSVLHGMVFKKETEG-----DVTSVKDAKIAVYSCPFDGMITET-KGTVLIKTA 262
           G  +  S+VL G++ +           +      K+A++     G  ++T +GTV++   
Sbjct: 206 GQRVIDSTVLPGILIEMSEVQLMRLLPIKKSTALKVALFCTTLSGDTSDTGEGTVVVSYG 265

Query: 263 EELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMALHYANKYNIMLVRLNSKWDLR 322
             L N     + L++   + I+D   ++V+    +      + N + I+ +       + 
Sbjct: 266 VSLENAVL--DQLLNLGRQLISD-HVDLVLCQKVIHPSLKQFLNMHRIIAIDRIGVTLME 322

Query: 323 RLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTD 382
            L K  G   +  L        G    V  ++ G      F     +  I +++L    D
Sbjct: 323 PLTKMTGTQPIGSLGSICPNSYGSVKDVCTAKFGSKH--FFHLIPNEATICSLLLCNRND 380

Query: 383 NLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITS----------YGETCPG 432
              D+++      ++  ++  ++   + GGG TE  LA  I              + C  
Sbjct: 381 TAWDELKLTCQTALHVLQLTLKEPWALLGGGCTETHLAAYIRHKTHNDPESILKDDECTQ 440

Query: 433 LE-QYAIKKFAEAFEAIPRALAENSG 457
            E Q   + F  A E++  +L  + G
Sbjct: 441 TELQLIAEAFCSALESVVGSLEHDGG 466


>gi|25914754 McKusick-Kaufman syndrome protein [Homo sapiens]
          Length = 570

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 84/446 (18%), Positives = 168/446 (37%), Gaps = 35/446 (7%)

Query: 39  LAQTTRTAYGPNGMNKMVINHLEK-LFVTNDAATILRELEVQHPAAKMIVMASHMQEQEV 97
           L +   + YGP+G  K + N     +  T+ ++ +L  L V HP  K++  +        
Sbjct: 29  LKRIVTSCYGPSGRLKQLHNGFGGYVCTTSQSSALLSHLLVTHPILKILTASIQNHVSSF 88

Query: 98  GDGTNFVLVFAGALLELAEELLRIGLSVSEVIEGYEIACRKAHEILPNLVC-CSAK-NLR 155
            D   F  +       L E + R+GL+ + VI   +         L +  C C    +  
Sbjct: 89  SDCGLFTAILC---CNLIENVQRLGLTPTTVIRLNKHLLSLCISYLKSETCGCRIPVDFS 145

Query: 156 DIDEVSSLLRTSIMSK-----QYGNEVFLAKLIAQACVSIFPDS--GHFNVDNIRVCKIL 208
               +  L+R+ + SK            ++ LI +A +   P++  GH  +    +  + 
Sbjct: 146 STQILLCLVRSILTSKPACMLTRKETEHVSALILRAFLLTIPENAEGHIILGKSLIVPLK 205

Query: 209 GSGISSSSVLHGMVFKKETEG-----DVTSVKDAKIAVYSCPFDGMITET-KGTVLIKTA 262
           G  +  S+VL G++ +           +      K+A++     G  ++T +GTV++   
Sbjct: 206 GQRVIDSTVLPGILIEMSEVQLMRLLPIKKSTALKVALFCTTLSGDTSDTGEGTVVVSYG 265

Query: 263 EELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADMALHYANKYNIMLVRLNSKWDLR 322
             L N     + L++   + I+D   ++V+    +      + N + I+ +       + 
Sbjct: 266 VSLENAVL--DQLLNLGRQLISD-HVDLVLCQKVIHPSLKQFLNMHRIIAIDRIGVTLME 322

Query: 323 RLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTD 382
            L K  G   +  L        G    V  ++ G      F     +  I +++L    D
Sbjct: 323 PLTKMTGTQPIGSLGSICPNSYGSVKDVCTAKFGSKH--FFHLIPNEATICSLLLCNRND 380

Query: 383 NLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITS----------YGETCPG 432
              D+++      ++  ++  ++   + GGG TE  LA  I              + C  
Sbjct: 381 TAWDELKLTCQTALHVLQLTLKEPWALLGGGCTETHLAAYIRHKTHNDPESILKDDECTQ 440

Query: 433 LE-QYAIKKFAEAFEAIPRALAENSG 457
            E Q   + F  A E++  +L  + G
Sbjct: 441 TELQLIAEAFCSALESVVGSLEHDGG 466


>gi|41399285 chaperonin [Homo sapiens]
          Length = 573

 Score = 40.4 bits (93), Expect = 0.004
 Identities = 105/585 (17%), Positives = 217/585 (37%), Gaps = 90/585 (15%)

Query: 1   MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHL 60
           +A H+ +A  +A+ +K GA       +A    +Q    LA       GP G   ++    
Sbjct: 18  LAPHLTRA--YAKDVKFGA-------DARALMLQGVDLLADAVAVTMGPKGRTVIIEQSW 68

Query: 61  EKLFVTNDAATILRELEVQHP----AAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAE 116
               VT D  T+ + ++++       AK++   ++   +E GDGT    V A ++ +   
Sbjct: 69  GSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGF 128

Query: 117 ELLRIGLSVSEVIEGYEIACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNE 176
           E +  G +  E+  G  +A       +  ++    K  + +     + + + +S     E
Sbjct: 129 EKISKGANPVEIRRGVMLA-------VDAVIAELKKQSKPVTTPEEIAQVATISANGDKE 181

Query: 177 VFLAKLIAQACVSIFPDSGHFNVDNIRVCKILGSGISSSSVLHGMVFKK---------ET 227
           +    +I+ A   +    G   V  ++  K L   +    ++ GM F +          +
Sbjct: 182 I--GNIISDAMKKV----GRKGVITVKDGKTLNDEL---EIIEGMKFDRGYISPYFINTS 232

Query: 228 EGDVTSVKDAKIAVYSCPFDGM--------ITETKGTVLIKTAEE---------LMNFSK 270
           +G     +DA + +       +        I       L+  AE+         ++N  K
Sbjct: 233 KGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLK 292

Query: 271 GEENLMDAQVKAIADTGAN-----VVVTGGKV----------ADMALHYANKYNIMLVRL 315
               ++  +     D   N      + TGG V           D+  H   K   ++V  
Sbjct: 293 VGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIV-- 350

Query: 316 NSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTI 375
            +K D   L        + +    ++E++    S Y  E  + ++      K    ++ +
Sbjct: 351 -TKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLA-----KLSDGVAVL 404

Query: 376 VLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLE- 434
            + G++D  +++ +  V D +N  +    ++ +V GGG     L + I +     P  E 
Sbjct: 405 KVGGTSDVEVNEKKDRVTDALNATRAAV-EEGIVLGGGCA---LLRCIPALDSLTPANED 460

Query: 435 -QYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDML 493
            +  I+      +     +A+N+GV+ + ++ K+     + +  VG D  A      +M+
Sbjct: 461 QKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKI----MQSSSEVGYD--AMAGDFVNMV 514

Query: 494 EAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSG 538
           E GI+D       A+  A   A  +   + ++   P     P  G
Sbjct: 515 EKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMG 559


>gi|31542947 chaperonin [Homo sapiens]
          Length = 573

 Score = 40.4 bits (93), Expect = 0.004
 Identities = 105/585 (17%), Positives = 217/585 (37%), Gaps = 90/585 (15%)

Query: 1   MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHL 60
           +A H+ +A  +A+ +K GA       +A    +Q    LA       GP G   ++    
Sbjct: 18  LAPHLTRA--YAKDVKFGA-------DARALMLQGVDLLADAVAVTMGPKGRTVIIEQSW 68

Query: 61  EKLFVTNDAATILRELEVQHP----AAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAE 116
               VT D  T+ + ++++       AK++   ++   +E GDGT    V A ++ +   
Sbjct: 69  GSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGF 128

Query: 117 ELLRIGLSVSEVIEGYEIACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNE 176
           E +  G +  E+  G  +A       +  ++    K  + +     + + + +S     E
Sbjct: 129 EKISKGANPVEIRRGVMLA-------VDAVIAELKKQSKPVTTPEEIAQVATISANGDKE 181

Query: 177 VFLAKLIAQACVSIFPDSGHFNVDNIRVCKILGSGISSSSVLHGMVFKK---------ET 227
           +    +I+ A   +    G   V  ++  K L   +    ++ GM F +          +
Sbjct: 182 I--GNIISDAMKKV----GRKGVITVKDGKTLNDEL---EIIEGMKFDRGYISPYFINTS 232

Query: 228 EGDVTSVKDAKIAVYSCPFDGM--------ITETKGTVLIKTAEE---------LMNFSK 270
           +G     +DA + +       +        I       L+  AE+         ++N  K
Sbjct: 233 KGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLK 292

Query: 271 GEENLMDAQVKAIADTGAN-----VVVTGGKV----------ADMALHYANKYNIMLVRL 315
               ++  +     D   N      + TGG V           D+  H   K   ++V  
Sbjct: 293 VGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIV-- 350

Query: 316 NSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTI 375
            +K D   L        + +    ++E++    S Y  E  + ++      K    ++ +
Sbjct: 351 -TKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLA-----KLSDGVAVL 404

Query: 376 VLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLE- 434
            + G++D  +++ +  V D +N  +    ++ +V GGG     L + I +     P  E 
Sbjct: 405 KVGGTSDVEVNEKKDRVTDALNATRAAV-EEGIVLGGGCA---LLRCIPALDSLTPANED 460

Query: 435 -QYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDML 493
            +  I+      +     +A+N+GV+ + ++ K+     + +  VG D  A      +M+
Sbjct: 461 QKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKI----MQSSSEVGYD--AMAGDFVNMV 514

Query: 494 EAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSG 538
           E GI+D       A+  A   A  +   + ++   P     P  G
Sbjct: 515 EKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMG 559


>gi|100816407 Bardet-Biedl syndrome 10 [Homo sapiens]
          Length = 723

 Score = 38.9 bits (89), Expect = 0.012
 Identities = 76/432 (17%), Positives = 154/432 (35%), Gaps = 78/432 (18%)

Query: 33  IQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHM 92
           +Q  + L        GP G   +      ++ ++ +   +L  L ++HP A+MIV     
Sbjct: 15  LQVAEVLEAIVSCCVGPEGRQVLCTKPTGEVLLSRNGGRLLEALHLEHPIARMIVDCVSS 74

Query: 93  QEQEVGDGTNFVLVFAGALLE---------------------------------LAEELL 119
             ++ GDG    ++F   LL                                  +++ LL
Sbjct: 75  HLKKTGDGAKTFIIFLCHLLRGLHAITDREKDPLMCENIQTHGRHWKNCSRWKFISQALL 134

Query: 120 RIGLSVSE-VIEGY--------------EIACRKAHEILPNLVCCSAKNLRDIDEVSSLL 164
                + + +++ Y                 CR + E+L     C      +   +S L+
Sbjct: 135 TFQTQILDGIMDQYLSRHFLSIFSSAKERTLCRSSLELLLEAYFCGRVGRNNHKFISQLM 194

Query: 165 RTSIMSKQYGNEVFLAKLIAQACVSIFP-DSGHFNVDNIRVCKILGSGISSSSVLHGMVF 223
                      + F   +  ++ + +F     HF   N+ V    G  +S S ++ G+V 
Sbjct: 195 ----------CDYFFKCMTCKSGIGVFELVDDHFVELNVGV---TGLPVSDSRIIAGLVL 241

Query: 224 KKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMD---AQV 280
           +K+      +  D ++ + +     + + T G+  I  +E    F   +  +M+   A +
Sbjct: 242 QKDFSVYRPADGDMRMVIVTETIQPLFS-TSGSEFILNSE--AQFQTSQFWIMEKTKAIM 298

Query: 281 KAIADTGANVVVTGGKVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPV 340
           K +      ++++  K  D+  +YA    I +V   S  ++  + + +G   L    PP 
Sbjct: 299 KHLHSQNVKLLISSVKQPDLVSYYAGVNGISVVECLSSEEVSLIRRIIG---LSPFVPPQ 355

Query: 341 LEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAIST-------IVLRGSTDNLMDDIERAVD 393
                   +  L +     ++  K     G IST       IVL G    L++  E A+ 
Sbjct: 356 AFSQCEIPNTALVKFCKPLILRSKRYVHLGLISTCAFIPHSIVLCGPVHGLIEQHEDALH 415

Query: 394 DGVNTFKVLTRD 405
             +   + L +D
Sbjct: 416 GALKMLRQLFKD 427


>gi|40217788 Bardet-Biedl syndrome 12 [Homo sapiens]
          Length = 710

 Score = 36.6 bits (83), Expect = 0.061
 Identities = 22/101 (21%), Positives = 44/101 (43%), Gaps = 1/101 (0%)

Query: 30  YRNIQACKELAQTTRTAYGPNGMNKMVIN-HLEKLFVTNDAATILRELEVQHPAAKMIVM 88
           +  +Q     A+T RT  GP   +K +I+    +  + +    +L  L++     +++  
Sbjct: 13  HMGLQQLSSFAETGRTFLGPLKSSKFIIDEECHESVLISSTVRLLESLDLTSAVGQLLNE 72

Query: 89  ASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVI 129
           A   Q      G + +L   GA     EE L +G+ +S ++
Sbjct: 73  AVQAQNNTYRTGISTLLFLVGAWSSAVEECLHLGVPISIIV 113


>gi|12738834 PRAME family member 2 [Homo sapiens]
          Length = 474

 Score = 35.0 bits (79), Expect = 0.18
 Identities = 29/79 (36%), Positives = 40/79 (50%), Gaps = 9/79 (11%)

Query: 102 NFVLVFAGALLELAEELLRIGLSVSE-VIEGYEIACRKAHEILPNLVCCS-------AKN 153
           ++VL+F  +L  L   L +I  S+   V+EG +I   +   ILP L CCS         N
Sbjct: 328 SYVLLFRISLEPLGALLEKIAASLETLVLEGCQIHYSQLSAILPGLSCCSQLTTFYFGSN 387

Query: 154 LRDIDEVSSLLR-TSIMSK 171
              ID +  LLR TS +SK
Sbjct: 388 CMSIDALKDLLRHTSGLSK 406


>gi|226246537 zinc finger protein 407 isoform 3 [Homo sapiens]
          Length = 1660

 Score = 34.7 bits (78), Expect = 0.23
 Identities = 17/54 (31%), Positives = 27/54 (50%)

Query: 48  GPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGT 101
           G +   +M + HL     T+DA ++L+ LE      ++ V  S  QE E G G+
Sbjct: 452 GTSETQRMYMKHLRTQMKTHDAESVLKHLEACSSVQRVCVTTSETQEAEQGQGS 505


>gi|226246535 zinc finger protein 407 isoform 2 [Homo sapiens]
          Length = 1815

 Score = 34.7 bits (78), Expect = 0.23
 Identities = 17/54 (31%), Positives = 27/54 (50%)

Query: 48  GPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGT 101
           G +   +M + HL     T+DA ++L+ LE      ++ V  S  QE E G G+
Sbjct: 452 GTSETQRMYMKHLRTQMKTHDAESVLKHLEACSSVQRVCVTTSETQEAEQGQGS 505


>gi|134133288 zinc finger protein 407 isoform 1 [Homo sapiens]
          Length = 2248

 Score = 34.7 bits (78), Expect = 0.23
 Identities = 17/54 (31%), Positives = 27/54 (50%)

Query: 48  GPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGT 101
           G +   +M + HL     T+DA ++L+ LE      ++ V  S  QE E G G+
Sbjct: 452 GTSETQRMYMKHLRTQMKTHDAESVLKHLEACSSVQRVCVTTSETQEAEQGQGS 505


>gi|22547221 tolloid-like 1 [Homo sapiens]
          Length = 1013

 Score = 34.3 bits (77), Expect = 0.30
 Identities = 28/107 (26%), Positives = 48/107 (44%), Gaps = 5/107 (4%)

Query: 132 YEIACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYG-NEVFLAKLIAQACVSI 190
           Y+ AC   +E+ P+   C A     + +++  + T    K+Y  N+  + +++A     I
Sbjct: 597 YQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRI 656

Query: 191 FPDSGHFNVDNIRVCKI----LGSGISSSSVLHGMVFKKETEGDVTS 233
                 F ++   VCK     + SG+SS S LHG     E    +TS
Sbjct: 657 SVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITS 703


>gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens]
          Length = 277

 Score = 32.0 bits (71), Expect = 1.5
 Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 3/42 (7%)

Query: 130 EGYEIA---CRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSI 168
           EG  +A   C K H I PN+ CC A    D D  + L+ +++
Sbjct: 65  EGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNL 106


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,399,594
Number of Sequences: 37866
Number of extensions: 776256
Number of successful extensions: 1940
Number of sequences better than 10.0: 27
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1880
Number of HSP's gapped (non-prelim): 28
length of query: 548
length of database: 18,247,518
effective HSP length: 107
effective length of query: 441
effective length of database: 14,195,856
effective search space: 6260372496
effective search space used: 6260372496
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.