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Search of human proteins with 48255879
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|48255879 troponin T type 2, cardiac isoform 2 [Homo sapiens]
(288 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|48255879 troponin T type 2, cardiac isoform 2 [Homo sapiens] 565 e-161
gi|48255881 troponin T type 2, cardiac isoform 3 [Homo sapiens] 554 e-158
gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens] 546 e-156
gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens] 544 e-155
gi|187173290 troponin T1, skeletal, slow isoform b [Homo sapiens] 318 3e-87
gi|187173292 troponin T1, skeletal, slow isoform c [Homo sapiens] 313 1e-85
gi|187173288 troponin T1, skeletal, slow isoform a [Homo sapiens] 308 5e-84
gi|5803203 troponin T3, skeletal, fast isoform 1 [Homo sapiens] 301 6e-82
gi|112789541 troponin T3, skeletal, fast isoform 4 [Homo sapiens] 295 2e-80
gi|112789538 troponin T3, skeletal, fast isoform 2 [Homo sapiens] 295 3e-80
gi|112789536 troponin T3, skeletal, fast isoform 3 [Homo sapiens] 287 7e-78
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 77 2e-14
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 76 4e-14
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 74 1e-13
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 73 3e-13
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 73 3e-13
gi|50726968 microfibrillar-associated protein 1 [Homo sapiens] 73 3e-13
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 72 4e-13
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 72 4e-13
gi|148746195 trichohyalin [Homo sapiens] 72 4e-13
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 72 6e-13
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 72 7e-13
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 70 2e-12
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 70 2e-12
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 70 3e-12
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 70 3e-12
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 69 4e-12
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 68 8e-12
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 68 8e-12
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 68 8e-12
>gi|48255879 troponin T type 2, cardiac isoform 2 [Homo sapiens]
Length = 288
Score = 565 bits (1456), Expect = e-161
Identities = 288/288 (100%), Positives = 288/288 (100%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM
Sbjct: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
Query: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL
Sbjct: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
Query: 121 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN
Sbjct: 121 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
Query: 181 MMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI 240
MMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI
Sbjct: 181 MMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI 240
Query: 241 YNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 288
YNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
Sbjct: 241 YNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 288
>gi|48255881 troponin T type 2, cardiac isoform 3 [Homo sapiens]
Length = 285
Score = 554 bits (1428), Expect = e-158
Identities = 285/288 (98%), Positives = 285/288 (98%), Gaps = 3/288 (1%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM
Sbjct: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
Query: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL
Sbjct: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
Query: 121 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN
Sbjct: 121 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
Query: 181 MMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI 240
MMHFGGYIQK TERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI
Sbjct: 181 MMHFGGYIQK---TERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI 237
Query: 241 YNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 288
YNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
Sbjct: 238 YNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 285
>gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens]
Length = 295
Score = 546 bits (1407), Expect = e-156
Identities = 285/298 (95%), Positives = 285/298 (95%), Gaps = 13/298 (4%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEE----------QEEAAEEDAEAEAETEETRAEEDEEEE 50
MSDIEEVVEEYEEEEQEEAAVEE QEEAAEEDAEAEAETEETRAEEDEEEE
Sbjct: 1 MSDIEEVVEEYEEEEQEEAAVEEEEDWREDEDEQEEAAEEDAEAEAETEETRAEEDEEEE 60
Query: 51 EAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHF 110
EAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHF
Sbjct: 61 EAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHF 120
Query: 111 ENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAED 170
ENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAED
Sbjct: 121 ENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAED 180
Query: 171 EARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLR 230
EARKKKALSNMMHFGGYIQK TERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLR
Sbjct: 181 EARKKKALSNMMHFGGYIQK---TERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLR 237
Query: 231 EKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 288
EKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
Sbjct: 238 EKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 295
>gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens]
Length = 282
Score = 544 bits (1401), Expect = e-155
Identities = 282/288 (97%), Positives = 282/288 (97%), Gaps = 6/288 (2%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
MSDIEEVVEEYEEEEQEE QEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM
Sbjct: 1 MSDIEEVVEEYEEEEQEE-----QEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 55
Query: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL
Sbjct: 56 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 115
Query: 121 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN
Sbjct: 116 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 175
Query: 181 MMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI 240
MMHFGGYIQK AQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI
Sbjct: 176 MMHFGGYIQK-AQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI 234
Query: 241 YNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 288
YNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
Sbjct: 235 YNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 282
>gi|187173290 troponin T1, skeletal, slow isoform b [Homo sapiens]
Length = 262
Score = 318 bits (815), Expect = 3e-87
Identities = 178/290 (61%), Positives = 211/290 (72%), Gaps = 30/290 (10%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
MSD EE +EYEEE+ EE A EE+EEA EE E AE EE R
Sbjct: 1 MSDTEE--QEYEEEQPEEEAAEEEEEAPEE-PEPVAEPEEER------------------ 39
Query: 61 EESKPKP-RSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEE 119
PKP R +P L+PPKIP+GERVDFDDIHRKRMEKDL ELQ LI+ HFE RKKEEEE
Sbjct: 40 ----PKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEE 95
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALS 179
LV+LK+RIERRR+ERAEQQR R E+E+ERQ +LAEE+ R+EEEE +++AED+A+KKK LS
Sbjct: 96 LVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLS 155
Query: 180 NM-MHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQ 238
NM HFGGY+ K E+K GKRQT RE K +IL+ER+K L ID++ E+QLREKA+EL
Sbjct: 156 NMGAHFGGYLVK---AEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSD 212
Query: 239 SIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 288
I+ LE+EKFDL K KQQKYEINVL NRI+ QK K GK +V GRWK
Sbjct: 213 WIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK 262
>gi|187173292 troponin T1, skeletal, slow isoform c [Homo sapiens]
Length = 251
Score = 313 bits (802), Expect = 1e-85
Identities = 165/255 (64%), Positives = 201/255 (78%), Gaps = 7/255 (2%)
Query: 36 AETEETRAEEDEEEEEAKEAEDGPMEESKPKP-RSFMPNLVPPKIPDGERVDFDDIHRKR 94
++TEE EE++ EEEA E E+ EE +PKP R +P L+PPKIP+GERVDFDDIHRKR
Sbjct: 2 SDTEEQEYEEEQPEEEAAEEEEE--EEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKR 59
Query: 95 MEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE 154
MEKDL ELQ LI+ HFE RKKEEEELV+LK+RIERRR+ERAEQQR R E+E+ERQ +LAE
Sbjct: 60 MEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAE 119
Query: 155 ERARREEEENRRKAEDEARKKKALSNM-MHFGGYIQKQAQTERKSGKRQTEREKKKKILA 213
E+ R+EEEE +++AED+A+KKK LSNM HFGGY+ K E+K GKRQT RE K +IL+
Sbjct: 120 EKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVK---AEQKRGKRQTGREMKVRILS 176
Query: 214 ERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQK 273
ER+K L ID++ E+QLREKA+EL I+ LE+EKFDL K KQQKYEINVL NRI+ QK
Sbjct: 177 ERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQK 236
Query: 274 VSKTRGKAKVTGRWK 288
K GK +V GRWK
Sbjct: 237 FRKGAGKGRVGGRWK 251
>gi|187173288 troponin T1, skeletal, slow isoform a [Homo sapiens]
Length = 278
Score = 308 bits (788), Expect = 5e-84
Identities = 178/306 (58%), Positives = 211/306 (68%), Gaps = 46/306 (15%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
MSD EE +EYEEE+ EE A EE+EEA EE E AE EE R
Sbjct: 1 MSDTEE--QEYEEEQPEEEAAEEEEEAPEE-PEPVAEPEEER------------------ 39
Query: 61 EESKPKP-RSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEE 119
PKP R +P L+PPKIP+GERVDFDDIHRKRMEKDL ELQ LI+ HFE RKKEEEE
Sbjct: 40 ----PKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEE 95
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALS 179
LV+LK+RIERRR+ERAEQQR R E+E+ERQ +LAEE+ R+EEEE +++AED+A+KKK LS
Sbjct: 96 LVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLS 155
Query: 180 NM-MHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQL--------- 229
NM HFGGY+ K E+K GKRQT RE K +IL+ER+K L ID++ E+QL
Sbjct: 156 NMGAHFGGYLVK---AEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLRARSAWLPP 212
Query: 230 -------REKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAK 282
REKA+EL I+ LE+EKFDL K KQQKYEINVL NRI+ QK K GK +
Sbjct: 213 SQPSCPAREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGR 272
Query: 283 VTGRWK 288
V GRWK
Sbjct: 273 VGGRWK 278
>gi|5803203 troponin T3, skeletal, fast isoform 1 [Homo sapiens]
Length = 258
Score = 301 bits (770), Expect = 6e-82
Identities = 166/281 (59%), Positives = 207/281 (73%), Gaps = 30/281 (10%)
Query: 12 EEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFM 71
EE EQ E EE+EEA EE+ E +E AEED EEE KP+P+
Sbjct: 4 EEVEQVEEQYEEEEEAQEEE-----EVQEDTAEEDAEEE-------------KPRPK--- 42
Query: 72 PNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRR 131
L PKIP+GE+VDFDDI +KR KDL ELQALI++HFE RKKEEEELV+LK+RIE+RR
Sbjct: 43 --LTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRR 100
Query: 132 AERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNM-MHFGGYIQK 190
AERAEQQRIR E+E+ERQNRLAEE+ARREEE+ +R+AED+ +KKKALS+M ++ Y+
Sbjct: 101 AERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYL-- 158
Query: 191 QAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDL 250
A+ ++K GK+QT RE KKKILAERRK L IDHL ED+LR+KAKELW++++ LE +KF+
Sbjct: 159 -AKADQKRGKKQTAREMKKKILAERRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEF 217
Query: 251 QEKFKQQKYEINVLRNRINDNQKVSKTRG---KAKVTGRWK 288
EK K+QKY+I LR+RI+ QK SK G K KV GRWK
Sbjct: 218 GEKLKRQKYDITTLRSRIDQAQKHSKKAGTPAKGKVGGRWK 258
>gi|112789541 troponin T3, skeletal, fast isoform 4 [Homo sapiens]
Length = 250
Score = 295 bits (756), Expect = 2e-80
Identities = 155/257 (60%), Positives = 198/257 (77%), Gaps = 12/257 (4%)
Query: 36 AETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRM 95
++ E + EE EEEE + E+ EE KP+P+ L PKIP+GE+VDFDDI +KR
Sbjct: 2 SDEEVEQVEEQYEEEEEAQEEEEVQEEEKPRPK-----LTAPKIPEGEKVDFDDIQKKRQ 56
Query: 96 EKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEE 155
KDL ELQALI++HFE RKKEEEELV+LK+RIE+RRAERAEQQRIR E+E+ERQNRLAEE
Sbjct: 57 NKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEE 116
Query: 156 RARREEEENRRKAEDEARKKKALSNM-MHFGGYIQKQAQTERKSGKRQTEREKKKKILAE 214
+ARREEE+ +R+AED+ +KKKALS+M ++ Y+ A+ ++K GK+QT RE KKKILAE
Sbjct: 117 KARREEEDAKRRAEDDLKKKKALSSMGANYSSYL---AKADQKRGKKQTAREMKKKILAE 173
Query: 215 RRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKV 274
RRK L IDHL ED+LR+KAKELW++++ LE +KF+ EK K+QKY+I LR+RI+ QK
Sbjct: 174 RRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDITTLRSRIDQAQKH 233
Query: 275 SKTRG---KAKVTGRWK 288
SK G K KV GRWK
Sbjct: 234 SKKAGTPAKGKVGGRWK 250
>gi|112789538 troponin T3, skeletal, fast isoform 2 [Homo sapiens]
Length = 256
Score = 295 bits (755), Expect = 3e-80
Identities = 159/262 (60%), Positives = 201/262 (76%), Gaps = 12/262 (4%)
Query: 31 DAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDI 90
D E E + EE EE+E +EEA E + + E + KPR P L PKIP+GE+VDFDDI
Sbjct: 3 DEEVE-QVEEQYEEEEEAQEEAAEVHE-EVHEPEEKPR---PKLTAPKIPEGEKVDFDDI 57
Query: 91 HRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQN 150
+KR KDL ELQALI++HFE RKKEEEELV+LK+RIE+RRAERAEQQRIR E+E+ERQN
Sbjct: 58 QKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQN 117
Query: 151 RLAEERARREEEENRRKAEDEARKKKALSNM-MHFGGYIQKQAQTERKSGKRQTEREKKK 209
RLAEE+ARREEE+ +R+AED+ +KKKALS+M ++ Y+ A+ ++K GK+QT RE KK
Sbjct: 118 RLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYL---AKADQKRGKKQTAREMKK 174
Query: 210 KILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRIN 269
KILAERRK L IDHL ED+LR+KAKELW++++ LE +KF+ EK K+QKY+I LR+RI+
Sbjct: 175 KILAERRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDITTLRSRID 234
Query: 270 DNQKVSKTRG---KAKVTGRWK 288
QK SK G K KV GRWK
Sbjct: 235 QAQKHSKKAGTPAKGKVGGRWK 256
>gi|112789536 troponin T3, skeletal, fast isoform 3 [Homo sapiens]
Length = 250
Score = 287 bits (735), Expect = 7e-78
Identities = 152/257 (59%), Positives = 195/257 (75%), Gaps = 12/257 (4%)
Query: 36 AETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRM 95
++ E + EE EEEE + E+ EE KP+P+ L PKIP+GE+VDFDDI +KR
Sbjct: 2 SDEEVEQVEEQYEEEEEAQEEEEVQEEEKPRPK-----LTAPKIPEGEKVDFDDIQKKRQ 56
Query: 96 EKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEE 155
KDL ELQALI++HFE RKKEEEELV+LK+RIE+RRAERAEQQRIR E+E+ERQNRLAEE
Sbjct: 57 NKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEE 116
Query: 156 RARREEEENRRKAEDEARKKKALSNM-MHFGGYIQKQAQTERKSGKRQTEREKKKKILAE 214
+ARREEE+ +R+AED+ +KKKALS+M ++ Y+ A+ ++K GK+QT RE KKKILAE
Sbjct: 117 KARREEEDAKRRAEDDLKKKKALSSMGANYSSYL---AKADQKRGKKQTAREMKKKILAE 173
Query: 215 RRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKV 274
RRK L IDHL ED+LR+KAKELW++++ LE +KF+ EK K+QKY+I +R R+ K
Sbjct: 174 RRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDIMNVRARVQMLAKF 233
Query: 275 SKTRG---KAKVTGRWK 288
SK G K KV GRWK
Sbjct: 234 SKKAGTPAKGKVGGRWK 250
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 77.0 bits (188), Expect = 2e-14
Identities = 73/295 (24%), Positives = 141/295 (47%), Gaps = 32/295 (10%)
Query: 5 EEVVEEYEEEEQE-EAAVEEQEEAAEEDAEAEAETEETRAEEDE----------EEEEAK 53
EE ++E+EE+ QE E + EQEE E E EE E++E E+EE
Sbjct: 367 EEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM 426
Query: 54 EAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEK-----DLNELQALIEA 108
++ M E + K R + K+ + E++ + R+ EK E +A +
Sbjct: 427 RRQEEMMWEKEEKIRE-----LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 481
Query: 109 HFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRL--AEERARREEEENRR 166
E +++EE++ ++++ R+ + EQ++IR E +++ Q + EE+ R +EE R+
Sbjct: 482 QEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQ 541
Query: 167 KA---EDEARKKKALSNMMHFGGYIQKQAQTERKSGK---RQTE--REKKKKILAERRKV 218
K E E + +K M + Q + R+ + RQ E RE+++KI + K+
Sbjct: 542 KEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKI 601
Query: 219 LAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQK 273
+ + ++Q EK E + + E + + +EK ++Q+ +I +I + ++
Sbjct: 602 REQEEMTQEQ-EEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEE 655
Score = 73.2 bits (178), Expect = 3e-13
Identities = 57/258 (22%), Positives = 129/258 (50%), Gaps = 22/258 (8%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEED---EEEEEAKEAEDGPME 61
+E + E EE+ QEE + EQE+ E++A+ + E+ R +E+ E+EE+ E+ E
Sbjct: 450 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE 509
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
+ K + + + + ++I R++ + ++E + I E ++EE++
Sbjct: 510 QEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK--EKIHEQEEKIRKQEEKMWRQEEKMH 567
Query: 122 SLKDRI-ERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
+++I E+ ++++IR + EK R+ EE+ R +EE + + E +++ +
Sbjct: 568 DQEEKIREQEEKVWRQEEKIREQEEKIREQ---EEKIREQEEMTQEQEEKMGEQEEKMCE 624
Query: 181 MMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI 240
+ Q Q E+ + + RE++KKI + K+ E+ ++E+ +++W+
Sbjct: 625 QEE-----KMQEQEEKMRRQEEKIREQEKKIREQEEKI----REQEEMMQEQEEKMWEQ- 674
Query: 241 YNLEAEKFDLQEKFKQQK 258
E + + +EK ++Q+
Sbjct: 675 ---EEKMCEQEEKMQEQE 689
Score = 61.6 bits (148), Expect = 8e-10
Identities = 52/287 (18%), Positives = 135/287 (47%), Gaps = 53/287 (18%)
Query: 4 IEEVVEEYE-----EEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE--EEEEAKEAE 56
++ VEE E ++QEE ++E+ E + + + + E+ R +E++ E+EE +
Sbjct: 342 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 401
Query: 57 DGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKE 116
+ M E + K R R E+ + E + E +++
Sbjct: 402 EEMMWEKEEKMR-------------------------RQEEMMWEKE-------EKMRRQ 429
Query: 117 EEELVSLKDRIERRRAERAEQQRIRNEREK-ERQNRLAEERARREEEENRRKAEDEARKK 175
EE + +++I + EQ++IR + EK + + ++ E+ R+E+E + E++ R++
Sbjct: 430 EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ 489
Query: 176 KALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAID---------HLNE 226
+ + Q++ E++ + + +R++++++ + K+ + H E
Sbjct: 490 EEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQE 549
Query: 227 DQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQK 273
+++R++ +++W+ E + D +EK ++Q+ ++ +I + ++
Sbjct: 550 EKIRKQEEKMWRQ----EEKMHDQEEKIREQEEKVWRQEEKIREQEE 592
Score = 57.0 bits (136), Expect = 2e-08
Identities = 55/276 (19%), Positives = 132/276 (47%), Gaps = 29/276 (10%)
Query: 25 EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGER 84
EE E++A+ + + + +E+ E + KE ++ + + +P D
Sbjct: 278 EELKEKNAKLQEKLQLVESEKSEIQLNVKE-----LKRKLERAKLLLPQQQLQAEADHLG 332
Query: 85 VDFDDIHRK-RMEKDLNEL-QALIEAHFENRKKEEEELVSLKDRIERRRAE-RAEQQRIR 141
+ + K + + + NEL L + E ++EE++ +++I+ + + R ++++IR
Sbjct: 333 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 392
Query: 142 NEREKERQNRLA----EERARREEE------ENRRKAED----EARKKKALSNMMHFGGY 187
+ EK R+ EE+ RR+EE E R+ E+ + K + L MH
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 452
Query: 188 IQKQA---QTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLE 244
I++Q Q E K +++ +E++ K+ + K+ E+++RE+ +++W+ +
Sbjct: 453 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE----QEEKIREQEEKMWRQEEKIH 508
Query: 245 AEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGK 280
++ +E+ +Q++ E+ +I + +++ + + K
Sbjct: 509 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEK 544
Score = 55.8 bits (133), Expect = 4e-08
Identities = 41/172 (23%), Positives = 84/172 (48%), Gaps = 19/172 (11%)
Query: 1 MSDIEEVVEEYEEEE-QEEAAVEEQEEAAEEDAEAEAETEETRAEEDE---EEEEAKEAE 56
M D EE + E EE+ ++E + EQEE E E E EE E++E E+EE +
Sbjct: 566 MHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQ 625
Query: 57 DGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKE 116
+ M+E + K R E++ + + E+ + E + +++ E ++
Sbjct: 626 EEKMQEQEEKMRR-----------QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 674
Query: 117 EEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKA 168
EE++ +++++ E+ E+ R + E+ E++ RL ++ + +E + +A
Sbjct: 675 EEKMCEQEEKMQ----EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 48.9 bits (115), Expect = 5e-06
Identities = 34/172 (19%), Positives = 81/172 (47%), Gaps = 7/172 (4%)
Query: 5 EEVVEEYEEE--EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
EE + + EE+ QEE +++E+ E++ + + E+ R E EE+ +E + EE
Sbjct: 549 EEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIR--EQEEKIREQEEKIREQEE 606
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ M E++ + +R E+ + E + I E +++EE +
Sbjct: 607 MTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 666
Query: 123 LKDRI---ERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDE 171
++++ E + E+ E+ + + E+ + ++ ++ E+ R ++E + + E
Sbjct: 667 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
Score = 30.0 bits (66), Expect = 2.5
Identities = 30/149 (20%), Positives = 66/149 (44%), Gaps = 21/149 (14%)
Query: 128 ERRRAERAEQQRIRNEREKERQN-------RLAEERARREEEENRRKAEDEARKK-KALS 179
+ ++A Q+ +R E E + + + A + ++ E EAR L
Sbjct: 170 DEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH 229
Query: 180 NMMHFGGYIQKQAQ---TERKSGKRQTEREKKKKILAERRKVLAID----HLNEDQLREK 232
+ F G +++ T++K R E L + R L+++ + +++L+EK
Sbjct: 230 DSWKFAGELEQALSAVATQKKKADRYIEE------LTKERDALSLELYRNTITDEELKEK 283
Query: 233 AKELWQSIYNLEAEKFDLQEKFKQQKYEI 261
+L + + +E+EK ++Q K+ K ++
Sbjct: 284 NAKLQEKLQLVESEKSEIQLNVKELKRKL 312
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 75.9 bits (185), Expect = 4e-14
Identities = 65/267 (24%), Positives = 120/267 (44%), Gaps = 23/267 (8%)
Query: 9 EEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPR 68
+E +E E+E E + E E E E E E R E E+E E + D + +K + R
Sbjct: 300 KERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDR 359
Query: 69 SFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIE 128
D +R D R+R D N+ ++ +R++E E ++R
Sbjct: 360 ------------DRDRERDRDRDRER-SSDRNKDRSRSREKSRDRERERER---ERERER 403
Query: 129 RRRAERAEQQRIRNEREKERQNRLAEERARREEEEN---RRKAEDEARKKKALSNMMHFG 185
R ER ++ ERE+ER+ ++R R E+EE+ RRK E + R+K+A
Sbjct: 404 EREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKN 463
Query: 186 GYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAI----DHLNEDQLREKAKELWQSIY 241
I+++ +T + + E E+++++ E +++ D +D + L + +
Sbjct: 464 WEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLR 523
Query: 242 NLEAEKFDLQEKFKQQKYEINVLRNRI 268
+ E E + K++K E+ +R R+
Sbjct: 524 DREKEMEADERDRKREKEELEEIRQRL 550
Score = 65.1 bits (157), Expect = 7e-11
Identities = 47/171 (27%), Positives = 83/171 (48%), Gaps = 8/171 (4%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
D EE E+ E + E + E+E A +E + E + E E+E E +E M +
Sbjct: 432 DREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAK 491
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ + F+ + D +R D ++K L + + +EA +RK+E+EEL
Sbjct: 492 EAKRLKEFLEDY------DDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEE 545
Query: 123 LKDRI--ERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDE 171
++ R+ E AE QR+ E E+ RQ ++ +E EEEE +++ E++
Sbjct: 546 IRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEK 596
Score = 64.3 bits (155), Expect = 1e-10
Identities = 66/286 (23%), Positives = 122/286 (42%), Gaps = 32/286 (11%)
Query: 18 EAAVEEQEEAAEEDAEAEAETEETRAE------EDEEEEEAKEAEDGPMEESKPKPRSFM 71
E + EEA +E+ + + + E E ++E++ P ++ K K
Sbjct: 186 ETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIF 245
Query: 72 PNL-VPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHF---------ENRKKEEEELV 121
V P IP + +DI+ ME+D +L + + F E KKE+E
Sbjct: 246 RRFPVAPLIPY-PLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQE 304
Query: 122 SLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRR-------KAEDEARK 174
K+R ER R E++R ERE+ER+ +E+ R E E R + D R+
Sbjct: 305 IEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRE 364
Query: 175 KKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAK 234
+ + + ++++ KS R+ ERE++++ ER + + E + RE+ +
Sbjct: 365 RDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERE-RERER 423
Query: 235 ELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGK 280
E E +K +E+ ++ YE L ++ + + + R K
Sbjct: 424 E-------REKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLK 462
Score = 63.5 bits (153), Expect = 2e-10
Identities = 72/293 (24%), Positives = 127/293 (43%), Gaps = 36/293 (12%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEE-DEEEEEAKEAE----- 56
+IE+ E E E + E E+E E + E E E E R E D + + KE +
Sbjct: 304 EIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDR 363
Query: 57 --DGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRK 114
D + + R+ + K D ER + R+R + E + E E +
Sbjct: 364 ERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERERER 423
Query: 115 KEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLA-------------EERARREE 161
+ E++ ++ E ER + +R E+E Q RL E+ A REE
Sbjct: 424 EREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREE 483
Query: 162 EENRRKAEDEARKKKALSN--------MMHFGGYIQKQAQ-TERKSGKRQTEREKKKKIL 212
E R A++ R K+ L + + G +QK+ + E++ + +R+++K+ L
Sbjct: 484 ERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEEL 543
Query: 213 AE-RRKVLAIDHLNED----QLREKAKELWQSIYNLEAEKFDLQEKFKQQKYE 260
E R+++LA H + D ++ ++A+ Q E E + +E+ KQ+K E
Sbjct: 544 EEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPES-EEEEEEKQEKEE 595
Score = 60.1 bits (144), Expect = 2e-09
Identities = 50/227 (22%), Positives = 102/227 (44%), Gaps = 22/227 (9%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
D E E E E+E E+E E + E E E E+ + + EE+EE +
Sbjct: 390 DREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERK 449
Query: 63 SKPKPRSFMPNLVPPKIPDGERV-------DFDDIHRKRMEKDLNELQALIEAHFENRKK 115
+ K ++ L +I + ++ + ++ R+ M K+ L+ +E + ++R
Sbjct: 450 LREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDD 509
Query: 116 EEEELVS-----LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAED 170
+ S L+DR + A+ +++R + E E+ RQ LAE + E R + E
Sbjct: 510 PKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEA 569
Query: 171 EARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRK 217
E R++ I+++ ++E + ++Q + EK+++ + E +
Sbjct: 570 ERRRQP----------QIKQEPESEEEEEEKQEKEEKREEPMEEEEE 606
Score = 34.7 bits (78), Expect = 0.100
Identities = 23/73 (31%), Positives = 38/73 (52%), Gaps = 6/73 (8%)
Query: 2 SDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
++++ + +E E Q + +QE +EE+ E + E EE R E EEEE E E P
Sbjct: 560 AELQRMEQEAERRRQPQI---KQEPESEEEEEEKQEKEEKREEPMEEEE---EPEQKPCL 613
Query: 62 ESKPKPRSFMPNL 74
+ +P S P++
Sbjct: 614 KPTLRPISSAPSV 626
Score = 30.4 bits (67), Expect = 1.9
Identities = 18/72 (25%), Positives = 29/72 (40%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
+ ++ E + E EQE + + E E EE+++E+E K E EE
Sbjct: 548 QRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEP 607
Query: 65 PKPRSFMPNLVP 76
+ P L P
Sbjct: 608 EQKPCLKPTLRP 619
Score = 28.5 bits (62), Expect = 7.2
Identities = 17/72 (23%), Positives = 29/72 (40%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
+E +EE + E + E + EAE + +E E EEE +E ++ + +
Sbjct: 540 KEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREE 599
Query: 65 PKPRSFMPNLVP 76
P P P
Sbjct: 600 PMEEEEEPEQKP 611
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 73.9 bits (180), Expect = 1e-13
Identities = 64/269 (23%), Positives = 131/269 (48%), Gaps = 36/269 (13%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEA--EAETEETRAEEDEEEEEAKEAEDG 58
M + EE + E EE+ E+ + EQEE +E+ + + + +E A+ +EE+ +E E+
Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 431
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEE 118
E+ K R KI + E++ ++ KR E++ Q E + +E+E
Sbjct: 432 IREQEKKMWRQ------EEKIHEQEKIREEE---KRQEQEEMWRQ-------EEKIREQE 475
Query: 119 ELVSLKDRIERRRAERAEQQRIRNEREK----ERQNRLAEERARREEE---ENRRKAEDE 171
E+ K+++ + R +++++ + EK E + R EE+ R+EE E K ++
Sbjct: 476 EIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQ 535
Query: 172 ARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLRE 231
K + MM +K + E K +++ R +++KI + K+ ++++RE
Sbjct: 536 EEKIREQEEMMQ--EQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKI----REQKEKIRE 589
Query: 232 KAKELWQSIYNLEAEKFDLQEKFKQQKYE 260
+ +++W+ + EK QE+ Q++ E
Sbjct: 590 QEEKIWE-----QEEKIREQEEMMQEQEE 613
Score = 73.6 bits (179), Expect = 2e-13
Identities = 56/276 (20%), Positives = 134/276 (48%), Gaps = 33/276 (11%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE----------------- 47
+E + E EE+ QEE + EQE+ E++A+ + E+ R +E++
Sbjct: 389 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE 448
Query: 48 -----EEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNEL 102
EEE+ +E E+ +E K + + + K+ + E++ + R E+ +++
Sbjct: 449 QEKIREEEKRQEQEEMWRQEEKIREQEEIWR-QKEKMHEQEKIRKQEEKVWRQEEKMHDQ 507
Query: 103 QALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREK---ERQNRLAEERARR 159
+ I E ++EE++ +++I + + EQ+ + E+E+ E++ ++ E+ R
Sbjct: 508 EEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMR 567
Query: 160 EEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTER---EKKKKILAERR 216
+EE R+ E++ R++K + Q++ E++ ++ E E+++K+ +
Sbjct: 568 RQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 627
Query: 217 KVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQE 252
K+ E+++R + +++W+ L ++ +QE
Sbjct: 628 KM----QEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 659
Score = 71.2 bits (173), Expect = 1e-12
Identities = 72/295 (24%), Positives = 139/295 (47%), Gaps = 41/295 (13%)
Query: 5 EEVVEEYEEEEQE-EAAVEEQEEAAEEDAEAEAETEETRAEEDE----------EEEEAK 53
EE ++E+EE+ QE E + EQEE E E EE E++E E+EE
Sbjct: 306 EEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM 365
Query: 54 EAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEK-----DLNELQALIEA 108
+ M E + K R + K+ + E++ + R+ EK E +A +
Sbjct: 366 RRLEEMMWEKEEKIRE-----LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 420
Query: 109 HFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKA 168
E +++EE++ + ++ R+ + EQ++IR E +++ Q E R+EE+ R +
Sbjct: 421 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQ-----EEMWRQEEKIREQE 475
Query: 169 EDEARKKKALSNMMHFGGYIQKQ-----AQTERKSGKRQTEREKKKKILAERRKVLAIDH 223
E +K+K MH I+KQ Q E+ + + RE+++K+ + K+ +
Sbjct: 476 EIWRQKEK-----MHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEE 530
Query: 224 L---NEDQLREKAKELWQSIYNL--EAEKFDLQEKFKQQKYEINVLRNRINDNQK 273
E+++RE+ + + + + + EK QEK ++Q+ +I +I + ++
Sbjct: 531 KIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKE 585
Score = 58.9 bits (141), Expect = 5e-09
Identities = 53/278 (19%), Positives = 129/278 (46%), Gaps = 57/278 (20%)
Query: 4 IEEVVEEYE-----EEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE--EEEEAKEAE 56
++ VEE E ++QEE ++E+ E + + + + E+ R +E++ E+EE +
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 340
Query: 57 DGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKE 116
+ M E + K R R E+ + E + E ++
Sbjct: 341 EEMMWEKEEKMR-------------------------RQEEMMWEKE-------EKMRRL 368
Query: 117 EEELVSLKDRIERRRAERAEQQRIRNEREK-ERQNRLAEERARREEEENRRKAEDEARKK 175
EE + +++I + EQ++IR + EK + + ++ E+ R+E+E + E++ R++
Sbjct: 369 EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ 428
Query: 176 KALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 235
+ +K + E+K +++ + +++KI E ++ + +++ + +E
Sbjct: 429 E------------EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEE 476
Query: 236 LWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQK 273
+W+ + EK QEK ++Q+ ++ +++D ++
Sbjct: 477 IWR-----QKEKMHEQEKIRKQEEKVWRQEEKMHDQEE 509
Score = 58.5 bits (140), Expect = 6e-09
Identities = 56/276 (20%), Positives = 132/276 (47%), Gaps = 29/276 (10%)
Query: 25 EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGER 84
EE E++A+ + + + +E+ E + KE ++ + + +P D
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKE-----LKRKLERAKLLLPQQQLQAEADHLG 271
Query: 85 VDFDDIHRK-RMEKDLNEL-QALIEAHFENRKKEEEELVSLKDRIERRRAE-RAEQQRIR 141
+ + K + + + NEL L + E ++EE++ +++I+ + + R ++++IR
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 331
Query: 142 NEREKERQNRLA----EERARREEE------ENRRKAED----EARKKKALSNMMHFGGY 187
+ EK R+ EE+ RR+EE E R+ E+ + K + L MH
Sbjct: 332 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEK 391
Query: 188 IQKQA---QTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLE 244
I++Q Q E K +++ +E++ K+ + K+ E+++RE+ K++W+ +
Sbjct: 392 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE----QEEKIREQEKKMWRQEEKIH 447
Query: 245 AEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGK 280
++ +E+ +Q++ E+ +I + +++ + + K
Sbjct: 448 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEK 483
Score = 54.3 bits (129), Expect = 1e-07
Identities = 42/173 (24%), Positives = 85/173 (49%), Gaps = 15/173 (8%)
Query: 1 MSDIEEVVEEYEEEE-QEEAAVEEQEEAAEEDAEAEAETEETRAEEDE----EEEEAKEA 55
M D EE + E EE+ ++E + EQEE E E E EE E++E +EE+ +E
Sbjct: 504 MHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQ 563
Query: 56 EDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKK 115
E +E K + + KI + E ++ E+ + E + +++ E +
Sbjct: 564 EKMRRQEEKIREQEEKIREQKEKIREQEEKIWE------QEEKIREQEEMMQEQEEKMWE 617
Query: 116 EEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKA 168
+EE++ +++++ E+ E+ R + E+ E++ RL ++ + +E + +A
Sbjct: 618 QEEKMCEQEEKMQ----EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 666
Score = 30.0 bits (66), Expect = 2.5
Identities = 30/149 (20%), Positives = 66/149 (44%), Gaps = 21/149 (14%)
Query: 128 ERRRAERAEQQRIRNEREKERQN-------RLAEERARREEEENRRKAEDEARKK-KALS 179
+ ++A Q+ +R E E + + + A + ++ E EAR L
Sbjct: 109 DEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH 168
Query: 180 NMMHFGGYIQKQAQ---TERKSGKRQTEREKKKKILAERRKVLAID----HLNEDQLREK 232
+ F G +++ T++K R E L + R L+++ + +++L+EK
Sbjct: 169 DSWKFAGELEQALSAVATQKKKADRYIEE------LTKERDALSLELYRNTITDEELKEK 222
Query: 233 AKELWQSIYNLEAEKFDLQEKFKQQKYEI 261
+L + + +E+EK ++Q K+ K ++
Sbjct: 223 NAKLQEKLQLVESEKSEIQLNVKELKRKL 251
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 73.2 bits (178), Expect = 3e-13
Identities = 61/283 (21%), Positives = 134/283 (47%), Gaps = 17/283 (6%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE----------EEEEAKE 54
+E + E EE+ QEE + EQE+ E++A+ + E+ R +E++ +EE+ E
Sbjct: 403 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE 462
Query: 55 AEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRK 114
E EE + + KI + E + E+ + + + + E +
Sbjct: 463 QEKIREEEKRQEQEEMWRQ--EEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIR 520
Query: 115 KEEEELVSLKDRIERRRAERAEQQRIRNEREK-ERQNRLAEERARREEEENRRKAEDEAR 173
++EE++ ++++ R+ + EQ+ + E EK Q ++ EE R+E+E+ + E++ R
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIR 580
Query: 174 --KKKALSNMMHFGGYIQKQAQTERKSGKRQTE-REKKKKILAERRKVLAIDHLNEDQLR 230
++K +K+ + E K K++ + RE+++KI + K+ + +Q
Sbjct: 581 EQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQ-E 639
Query: 231 EKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQK 273
E +E + + E + + +EK ++Q+ + +I + +K
Sbjct: 640 EMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEK 682
Score = 70.5 bits (171), Expect = 2e-12
Identities = 61/283 (21%), Positives = 145/283 (51%), Gaps = 32/283 (11%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAE--AEAETEETRAEEDEEEEEAKEAEDG 58
M + EE + E EE+ E+ + EQEE +E+ + + + +E A+ +EE+ +E E+
Sbjct: 386 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 445
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRK-----RMEKDLNELQALIEAHFENR 113
E+ K R KI + E++ ++ ++ R E+ ++E Q I E
Sbjct: 446 IREQEKKMWRQ------EEKIHEQEKIREEEKRQEQEEMWRQEEKIHE-QEEIWRQKEKM 498
Query: 114 KKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEAR 173
++EE++ ++++ R ++++IR + EK R+ EE+ R+EE+ R + E+ R
Sbjct: 499 HEQEEKIRKQEEKVWR------QEEKIREQEEKIREQ---EEKMWRQEEKIREQ-EEMWR 548
Query: 174 KKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKA 233
+++ + ++Q Q ++ + + RE+++K+ + K+ E++ +E+
Sbjct: 549 EEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKI----REQEEKRQEQE 604
Query: 234 KELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSK 276
+++W+ E + + +EK ++Q+ +I +I + +++++
Sbjct: 605 EKMWKQ----EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQ 643
Score = 64.3 bits (155), Expect = 1e-10
Identities = 60/270 (22%), Positives = 117/270 (43%), Gaps = 66/270 (24%)
Query: 5 EEVVEEYEEEEQE-EAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEES 63
EE ++E+EE+ QE E + EQEE E E EE E++E+ +E M E
Sbjct: 306 EEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM----MWEK 361
Query: 64 KPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSL 123
+ K R R E+ + E + E +++EE +
Sbjct: 362 EEKMR-------------------------RQEEMMWEKE-------EKMRRQEEMMWEK 389
Query: 124 KDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMH 183
+++I + EQ++IR + EK ++ E+ +R+E+E + ++E
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE------------ 437
Query: 184 FGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNL 243
K + E K RE++KK+ + K+ + + E++ R++ +E+W+
Sbjct: 438 ------KIREQEEKI------REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR----- 480
Query: 244 EAEKFDLQEKFKQQKYEINVLRNRINDNQK 273
+ EK QE+ +QK +++ +I ++
Sbjct: 481 QEEKIHEQEEIWRQKEKMHEQEEKIRKQEE 510
Score = 63.2 bits (152), Expect = 3e-10
Identities = 60/266 (22%), Positives = 122/266 (45%), Gaps = 43/266 (16%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE----EEEEAKEAEDGPM 60
EE+ + E+ ++E + +QEE E E EE E++E +EE+ +E E+
Sbjct: 489 EEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR 548
Query: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQAL-------IEAHFENR 113
EE K + KI + E+ + R E+ + E + I E R
Sbjct: 549 EEEKMHEQE--------KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKR 600
Query: 114 KKEEEELVSLKDRIERRRAERAEQQ-RIRNEREKERQNRLAEERARREEEENRRKAEDEA 172
+++EE++ +++I + + EQ+ +IR + EK R+ EE + +EE+ + E
Sbjct: 601 QEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQ---EEMTQEQEEKMGEQEEKMC 657
Query: 173 RKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREK 232
+++ + Q Q E + + RE++KKI + K+ E+ ++E+
Sbjct: 658 EQEEKM------------QEQEETMWRQEEKIREQEKKIREQEEKI----REQEEMMQEQ 701
Query: 233 AKELWQSIYNLEAEKFDLQEKFKQQK 258
+++W+ E + + +EK ++Q+
Sbjct: 702 EEKMWEQ----EEKMCEQEEKMQEQE 723
Score = 61.6 bits (148), Expect = 8e-10
Identities = 45/198 (22%), Positives = 104/198 (52%), Gaps = 15/198 (7%)
Query: 94 RMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRA---ERAEQQRIRNER--EKER 148
R E+ + E + I+ E +++EE++ ++++ R+ E+ E+ R + E EKE
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 363
Query: 149 QNRLAEERARREEEENRRKAE---DEARKKKALSNMMHFGGYIQKQA---QTERKSGKRQ 202
+ R EE +EE+ RR+ E ++ K + L MH I++Q Q E K +++
Sbjct: 364 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE 423
Query: 203 TEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEIN 262
+E++ K+ + K+ E+++RE+ K++W+ + ++ +E+ +Q++ E+
Sbjct: 424 KRQEQEAKMWRQEEKIRE----QEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMW 479
Query: 263 VLRNRINDNQKVSKTRGK 280
+I++ +++ + + K
Sbjct: 480 RQEEKIHEQEEIWRQKEK 497
Score = 58.2 bits (139), Expect = 8e-09
Identities = 49/215 (22%), Positives = 97/215 (45%), Gaps = 9/215 (4%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAK----EAEDGPM 60
EE + E EE +EE + EQE+ EE+ E E + R EE E+E K E +
Sbjct: 537 EEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQ 596
Query: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
EE + + M E++ + + E+ + E + + + E ++EE++
Sbjct: 597 EEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKM 656
Query: 121 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
+++++ + Q+ RE+E++ R EE+ R +EE + E E + +
Sbjct: 657 CEQEEKMQEQEETMWRQEE--KIREQEKKIREQEEKIREQEEMMQ---EQEEKMWEQEEK 711
Query: 181 MMHFGGYIQKQAQTERKSGKRQTEREKKKKILAER 215
M +Q+Q + R+ ++ E+E + + E+
Sbjct: 712 MCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746
Score = 48.9 bits (115), Expect = 5e-06
Identities = 52/274 (18%), Positives = 127/274 (46%), Gaps = 20/274 (7%)
Query: 25 EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGER 84
EE E++A+ + + + +E+ E + KE ++ + + +P D
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKE-----LKRKLERAKLLLPQQQLQAEADHLG 271
Query: 85 VDFDDIHRK-RMEKDLNEL-QALIEAHFENRKKEEEELVSLKDRIERRRAE-RAEQQRIR 141
+ + K + + + NEL L + E ++EE++ +++I+ + + R ++++IR
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 331
Query: 142 NEREKERQNRLAEERARREEEENRRKAED---EARKKKALSNMMHFGGYIQKQAQTERKS 198
+ EK R+ +E E+EE R+ E+ E +K M + + + Q E
Sbjct: 332 EQEEKMRR----QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW 387
Query: 199 GKRQTEREKKKKILAERRKVLAIDHLNEDQLR----EKAKELWQSIYNLEAEKFDLQEKF 254
K + RE ++K + E+ K+ + +++ + EK +E ++ E + + +EK
Sbjct: 388 EKEEKIRELEEK-MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 446
Query: 255 KQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 288
++Q+ ++ +I++ +K+ + + + W+
Sbjct: 447 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR 480
Score = 48.5 bits (114), Expect = 7e-06
Identities = 36/161 (22%), Positives = 75/161 (46%), Gaps = 33/161 (20%)
Query: 5 EEVVEEYEEE-EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE---EEEEAKEAEDGPM 60
EE ++E EE+ ++E + EQEE +E E E EE E++E E+EE ++ +
Sbjct: 618 EEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKI 677
Query: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
E + K R E+ + E + +++ E ++EE++
Sbjct: 678 REQEKKIR-------------------------EQEEKIREQEEMMQEQEEKMWEQEEKM 712
Query: 121 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREE 161
+++++ E+ E+ R + E+ E++ RL ++ + +E
Sbjct: 713 CEQEEKMQ----EQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 35.0 bits (79), Expect = 0.076
Identities = 26/79 (32%), Positives = 38/79 (48%), Gaps = 11/79 (13%)
Query: 1 MSDIEEVVEEYEEEEQE--------EAAVEEQEEAAEEDAEAEAETEETRAEEDE---EE 49
M + EE + E EE+ QE E + EQE+ E E E EE E++E E+
Sbjct: 649 MGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 708
Query: 50 EEAKEAEDGPMEESKPKPR 68
EE ++ M+E + K R
Sbjct: 709 EEKMCEQEEKMQEQEEKMR 727
Score = 30.0 bits (66), Expect = 2.5
Identities = 30/149 (20%), Positives = 66/149 (44%), Gaps = 21/149 (14%)
Query: 128 ERRRAERAEQQRIRNEREKERQN-------RLAEERARREEEENRRKAEDEARKK-KALS 179
+ ++A Q+ +R E E + + + A + ++ E EAR L
Sbjct: 109 DEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH 168
Query: 180 NMMHFGGYIQKQAQ---TERKSGKRQTEREKKKKILAERRKVLAID----HLNEDQLREK 232
+ F G +++ T++K R E L + R L+++ + +++L+EK
Sbjct: 169 DSWKFAGELEQALSAVATQKKKADRYIEE------LTKERDALSLELYRNTITDEELKEK 222
Query: 233 AKELWQSIYNLEAEKFDLQEKFKQQKYEI 261
+L + + +E+EK ++Q K+ K ++
Sbjct: 223 NAKLQEKLQLVESEKSEIQLNVKELKRKL 251
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 72.8 bits (177), Expect = 3e-13
Identities = 72/286 (25%), Positives = 128/286 (44%), Gaps = 35/286 (12%)
Query: 9 EEYEEEEQEEAAVEEQEEAAE-----EDAEAEAETEETRAEEDEEEEEAKEAEDGPMEES 63
EE E QE +EE E + + +AE +E + +E+EEEE+ K G +
Sbjct: 150 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVE 209
Query: 64 ---KPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
+ K V + +G+ + + E+ +E+ +H E ++E++E
Sbjct: 210 VMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEI-----SHHEKMEEEDKE- 263
Query: 121 VSLKDRIERRRAERAEQQRIRNEREKE----------RQNRLAEERARREEEENRRKAED 170
+ ER R E E++RI+ E++K+ + A+ER RRE EE R E+
Sbjct: 264 ---RAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREE 320
Query: 171 EARKKKALSNMMHFGGYIQKQAQTERKSGKRQTER--EKKKKILAERRKVLAIDHLNEDQ 228
E R + + +K+A ER+ K + +R E++++I E ++ +
Sbjct: 321 EKRAAEERQRIKE----EEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAE 376
Query: 229 LREKAK-ELWQSIYNLEAEKFDLQE-KFKQQKYEINVLRNRINDNQ 272
EKAK E + LE +K +QE K K +K E + +N+ +
Sbjct: 377 EEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKK 422
Score = 72.0 bits (175), Expect = 6e-13
Identities = 71/289 (24%), Positives = 131/289 (45%), Gaps = 25/289 (8%)
Query: 10 EYEEEEQEEAAVEEQEEAAEEDAEAEAETEETR----AEEDEEEEEAKEAEDGPMEESKP 65
E E E+EE + QE E+ E ++ + AEE+++E++ KE E EE KP
Sbjct: 143 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEE----EEEKP 198
Query: 66 KPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKD 125
K S N V + + ++ ++ N + E E +++ + +S +
Sbjct: 199 KRGSIGENQVEVMVEEKTTESQEETVVMSLK---NGQISSEEPKQEEEREQGSDEISHHE 255
Query: 126 RIERRRAERAEQQRIRNEREK------ERQNRLAEERARREEEENRRKAEDEARKKKALS 179
++E ERAE +R R E E+ E+ ++A+ERAR E EE E E R+ +
Sbjct: 256 KMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERE 315
Query: 180 NMMHFGGYIQKQAQTERKSGKRQTER-EKKKKILAERRKVLAIDHLNEDQLREKAKELWQ 238
M +K+A ER+ K + +R ++++ + E K A + + ++A E Q
Sbjct: 316 RMRE----EEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 371
Query: 239 SIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRW 287
E EK ++E+ + ++ E + K+ + + K+ G+W
Sbjct: 372 RARAEEEEKAKVEEQKRNKQLE---EKKHAMQETKIKGEKVEQKIEGKW 417
Score = 72.0 bits (175), Expect = 6e-13
Identities = 69/296 (23%), Positives = 135/296 (45%), Gaps = 32/296 (10%)
Query: 2 SDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETE---ETRAEEDEEEEEAKEAEDG 58
+D + E +E++++E EE+EE + + E + E E + E +EE ++G
Sbjct: 175 NDWRDAEENKKEDKEKE---EEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNG 231
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKK--- 115
+ +PK +I E+++ +D R E+ E + E KK
Sbjct: 232 QISSEEPKQEEEREQ-GSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIAD 290
Query: 116 -----EEEELVSLKDRIERRRAE-----RAEQQRIRNERE--KERQNRLAEERARREEEE 163
E EE + ++R ERR AE R E++R ER+ KE + R AEER R +EEE
Sbjct: 291 ERARIEAEEKAAAQER-ERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE 349
Query: 164 NRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDH 223
+R AE+ R K+ ++Q + K + E +K+ K L E++ +
Sbjct: 350 -KRAAEERQRIKEEEKRAAE-----ERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETK 403
Query: 224 LNEDQLREKAKELWQSIYNLEAEKFD---LQEKFKQQKYEINVLRNRINDNQKVSK 276
+ +++ +K + W + + +K L+++ +++ ++ R ++ +++ K
Sbjct: 404 IKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFK 459
Score = 57.8 bits (138), Expect = 1e-08
Identities = 73/276 (26%), Positives = 122/276 (44%), Gaps = 37/276 (13%)
Query: 9 EEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPR 68
E+ EEE++E A E AEE +AE ++ A+E E ++A E + + R
Sbjct: 255 EKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEER 314
Query: 69 SFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIE 128
M + +R+ K EK E + I+ E K+ EE +K+ E
Sbjct: 315 ERMREEEKRAAEERQRI-------KEEEKRAAEERQRIK---EEEKRAAEERQRIKEE-E 363
Query: 129 RRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYI 188
+R AE E+QR R E E++ + EE+ R ++ E ++ A E + K G ++
Sbjct: 364 KRAAE--ERQRARAEEEEKAK---VEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWV 418
Query: 189 -QKQAQTERKSG---KRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLE 244
+K+AQ ++ K+Q E EK K+ A+R K L ED+ K +E+
Sbjct: 419 NEKKAQEDKLQTAVLKKQGE-EKGTKVQAKREK------LQEDKPTFKKEEI-------- 463
Query: 245 AEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGK 280
K + +K K+ K E+ +R +V G+
Sbjct: 464 --KDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE 497
Score = 55.1 bits (131), Expect = 7e-08
Identities = 66/281 (23%), Positives = 122/281 (43%), Gaps = 37/281 (13%)
Query: 9 EEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPR 68
EE E+ + EE++ AAEE A AE EE E+++ + E + M+E+K K
Sbjct: 348 EEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE 407
Query: 69 SFMPNLVPPKIPDGERVDFDDIH----RKRMEKDLNELQALIEAHFENR---KKEE---- 117
+ + K + ++ D + +K+ E+ ++QA E E++ KKEE
Sbjct: 408 K-VEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE 466
Query: 118 ---------EELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARR----EEEEN 164
EE+ S DR + +++ + K +N + R +E E
Sbjct: 467 KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEG 526
Query: 165 RRKAE-----DEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAE---RR 216
+ E +E R+++ + F QKQ + + + + +RE+++K+L E RR
Sbjct: 527 APQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRR 586
Query: 217 KVLAIDH-LNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQ 256
K D L E++ + + KE I AE + ++K +
Sbjct: 587 KQEEADRKLREEEEKRRLKE---EIERRRAEAAEKRQKMPE 624
Score = 47.4 bits (111), Expect = 1e-05
Identities = 70/313 (22%), Positives = 128/313 (40%), Gaps = 57/313 (18%)
Query: 9 EEYEEEEQEEAAVEEQEEAAEE-----DAEAEAETEETRAEED-------------EEEE 50
EE E+ + EE++ AAEE + E A E R +E+ EEEE
Sbjct: 320 EEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEE 379
Query: 51 EAK----------EAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIH----RKRME 96
+AK E + M+E+K K + + K + ++ D + +K+ E
Sbjct: 380 KAKVEEQKRNKQLEEKKHAMQETKIKGEK-VEQKIEGKWVNEKKAQEDKLQTAVLKKQGE 438
Query: 97 KDLNELQALIEAHFENR---KKEE-------------EELVSLKDRIERRRAERAEQQRI 140
+ ++QA E E++ KKEE EE+ S DR + +++
Sbjct: 439 EKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEF 498
Query: 141 RNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQ--AQTERKS 198
+ K +N + R + + + K L + G + + + ++K
Sbjct: 499 MTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQ 558
Query: 199 GKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQK 258
+ E E+ KK ERRKV L E++ R K +E + + E EK L+E+ ++++
Sbjct: 559 QEAALELEELKKKREERRKV-----LEEEEQRRKQEEADRKLRE-EEEKRRLKEEIERRR 612
Query: 259 YEINVLRNRINDN 271
E R ++ ++
Sbjct: 613 AEAAEKRQKMPED 625
Score = 38.9 bits (89), Expect = 0.005
Identities = 43/203 (21%), Positives = 83/203 (40%), Gaps = 37/203 (18%)
Query: 107 EAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARR------- 159
E E R+++ EE+ +RI +R + E++ R R + RQ RL +++
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
Query: 160 EEEENRRKAEDEARKKKALSNMMHFG----GYIQKQAQTERKSGKRQTEREKKKK----- 210
+ E N + + + K +N G ++++ A+ E + KR E +++K
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Query: 211 -----ILAERRKVLAIDHLNEDQLREKAKELWQSIYNLE----------------AEKFD 249
+ R++ NE +E+ E Q Y +E AE+
Sbjct: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
Query: 250 LQEKFKQQKYEINVLRNRINDNQ 272
++K K+++ E R I +NQ
Sbjct: 185 KEDKEKEEEEEEKPKRGSIGENQ 207
Score = 34.7 bits (78), Expect = 0.100
Identities = 30/112 (26%), Positives = 50/112 (44%), Gaps = 3/112 (2%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE + EEEEQ E + EE+ + + E R + E+ K EDG ++ K
Sbjct: 573 EERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 632
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKE 116
P + F P KI ER +F + ++ + QA I + ++R ++
Sbjct: 633 PF-KCFTPKGSSLKIE--ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQ 681
>gi|50726968 microfibrillar-associated protein 1 [Homo sapiens]
Length = 439
Score = 72.8 bits (177), Expect = 3e-13
Identities = 74/297 (24%), Positives = 139/297 (46%), Gaps = 35/297 (11%)
Query: 1 MSDIEEVVEEYE---EEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAK---- 53
M +E EE++ + +++EA EEQEE + D + R ED EE A+
Sbjct: 50 MESSDEEDEEFQFIKKAKEQEAEPEEQEEDSSSDPRLRRL--QNRISEDVEERLARHRKI 107
Query: 54 -EAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFEN 112
E E +S+ + ++ + E +D ++I R+R ++ +
Sbjct: 108 VEPEVVGESDSEVEGDAWRMEREDSSEEEEEEIDDEEIERRR---------GMMRQRAQE 158
Query: 113 RKKEEEELVSLKDRIERRRAERAEQQRIRNE---REKERQNRLAEERARREEEENRRKAE 169
RK EE E++ ++D E R E +E + E E E + RL R+++ ++ E
Sbjct: 159 RKNEEMEVMEVED--EGRSGEESESESEYEEYTDSEDEMEPRLKPVFIRKKDRVTVQERE 216
Query: 170 DEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLN-EDQ 228
EA K+K L ++ A+ RK + E E KK++ +R + A+D LN +D+
Sbjct: 217 AEALKQKELEQEA------KRMAEERRKYTLKIVEEETKKELEENKRSLAALDALNTDDE 270
Query: 229 LREKAKELW--QSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKV 283
E+ E W + + ++ ++ D +E +++K EI +RN + + ++ ++ R KV
Sbjct: 271 NDEEEYEAWKVRELKRIKRDRED-REALEKEKAEIERMRN-LTEEERRAELRANGKV 325
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 72.4 bits (176), Expect = 4e-13
Identities = 64/273 (23%), Positives = 130/273 (47%), Gaps = 30/273 (10%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEE--EEEAKEAEDG 58
M + E+ + EE+ QEE + E+E+ E+ E E EE +++E E+E KE +
Sbjct: 432 MQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 491
Query: 59 PMEESKPK--PRSFMPNL------VPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHF 110
+ E K K + M KI D E + + R EK + E + +
Sbjct: 492 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEK-MREQEDQMWEQE 550
Query: 111 ENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAED 170
E + +E+++ ++R+E++ E+ ++ + E+ +E + E+ REEEE R+ E+
Sbjct: 551 EKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 610
Query: 171 EARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDH--LNEDQ 228
+ ++++ + Q Q E+ + + +E+++K+ + K+ + + +
Sbjct: 611 KMQEQEE-----------KMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQR 659
Query: 229 LREKAKELWQSIYNLEAEKFDLQEKFKQQKYEI 261
L E+ ++LW E EK QEK ++Q+ +I
Sbjct: 660 LPEQKEKLW------EHEKMQEQEKMQEQEEKI 686
Score = 68.2 bits (165), Expect = 8e-12
Identities = 57/264 (21%), Positives = 127/264 (48%), Gaps = 25/264 (9%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEE---EEEAKEAEDGPME 61
E+ + E E+E +E+ + EQEE +E E E EE E++E+ +EE ++ M
Sbjct: 327 EKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 386
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEA--HFENRKKEEEE 119
E + K R ER+ D + E+ + E + + E KK +E+
Sbjct: 387 EQEQKMRD-----------QEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALS 179
+D+ E+ + E ++R + RE+E R EE+ ++ +EEN + E++ +++ L
Sbjct: 436 EKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK-QEENMWEQEEKEWQQQRLP 494
Query: 180 NMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELW-- 237
+K + E K +++ + ++++ + +K+ ++++RE+ ++W
Sbjct: 495 EQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM-----WRQEKMREQEDQMWEQ 549
Query: 238 -QSIYNLEAEKFDLQEKFKQQKYE 260
+ + + E + +D +E+ +++ E
Sbjct: 550 EEKMRDQEQKMWDQEERMEKKTQE 573
Score = 67.4 bits (163), Expect = 1e-11
Identities = 57/288 (19%), Positives = 142/288 (49%), Gaps = 34/288 (11%)
Query: 1 MSDIEEVVEEYEEE--EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDG 58
M + EE ++E EE+ EQEE E++E+ E+ E + + E+ +E+E+ +E E+
Sbjct: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKD------LNELQALIEAHFEN 112
E+ K + ++ K D E++ ++ R+R +K + E + ++ E
Sbjct: 686 IWEQEKMEKKTQEQE---KKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEK 742
Query: 113 RKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEA 172
+++EEE+ ++++ + + EQQR+ ++EK ++ +E+ + E+E + + ++E
Sbjct: 743 MQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEE- 801
Query: 173 RKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREK 232
+ + Q E+ G+ + R +++K+ + K+ E+++ +
Sbjct: 802 ----------------KMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWG----QEEKMWGQ 841
Query: 233 AKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGK 280
+++W +E + +EK ++Q+ ++ ++ + ++ K RG+
Sbjct: 842 EEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE--KMRGQ 887
Score = 66.2 bits (160), Expect = 3e-11
Identities = 51/264 (19%), Positives = 130/264 (49%), Gaps = 29/264 (10%)
Query: 5 EEVVEEYEEE--EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+E + E E++ EQEE +++++ +++ E +T+E + ++EE+ +E E M E
Sbjct: 536 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEER--MRE 593
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ K R + E + + + E+ + E + + E +++EE++
Sbjct: 594 REKKMRE-----------EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWE 642
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
++++ + + EQQR+ ++EK ++ +E+ + +E+E + +++ KK
Sbjct: 643 QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQ--- 699
Query: 183 HFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHL---NEDQLREKAKELWQS 239
+K+ + K + ++ RE++KK+ E + + E++++E+ +E+W+
Sbjct: 700 ------EKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQ 753
Query: 240 IYNL--EAEKFDLQEKFKQQKYEI 261
+ + EK Q++ +QK ++
Sbjct: 754 EEKMWEQEEKMWEQQRLPEQKEKL 777
Score = 63.9 bits (154), Expect = 2e-10
Identities = 52/275 (18%), Positives = 129/275 (46%), Gaps = 20/275 (7%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAK------- 53
M + +E + E EE +E+ + EQ E E+ + + + ++TR +E++ +EE +
Sbjct: 399 MWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKK 458
Query: 54 -EAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFEN 112
E+ M E + K + N+ + + ++ + K E++ + Q E
Sbjct: 459 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 518
Query: 113 RKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRL----AEERARREEEENRRKA 168
+ +++EE+ + ++ R+ R ++ ++ + EK R EER ++ +E +K
Sbjct: 519 KIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKT 578
Query: 169 EDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQ 228
D+ K + M ++++ + R+ ++ E+E+K + E+ E++
Sbjct: 579 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM------WEQEEK 632
Query: 229 LREKAKELWQSIYNL--EAEKFDLQEKFKQQKYEI 261
++E+ +++W+ + + EK Q++ +QK ++
Sbjct: 633 MQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKL 667
Score = 63.5 bits (153), Expect = 2e-10
Identities = 59/266 (22%), Positives = 123/266 (46%), Gaps = 17/266 (6%)
Query: 16 QEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLV 75
QEE +E+E +E + E + R EE E+E K E +E K +
Sbjct: 271 QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE----QEEKMWRQEKRLREQ 326
Query: 76 PPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRI-ERRRAER 134
++ + E+ + + E+ + E + + E +++EE++ ++R+ E+ + R
Sbjct: 327 EKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 386
Query: 135 AEQQRIRNEREK--ERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQA 192
++Q++R++ E+ E+ RL E+ R E+E + ++ R++K + +K
Sbjct: 387 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQE------KKTR 440
Query: 193 QTERKSGKRQTEREKKKKILAE----RRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKF 248
E K + + RE++KK+ E R + + E+ ++ KE Q + EK
Sbjct: 441 DQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 500
Query: 249 DLQEKFKQQKYEINVLRNRINDNQKV 274
QEK ++Q+ +I +I D +++
Sbjct: 501 WEQEKMQEQEEKIWEQEEKIRDQEEM 526
Score = 60.1 bits (144), Expect = 2e-09
Identities = 59/289 (20%), Positives = 136/289 (47%), Gaps = 40/289 (13%)
Query: 3 DIEEVVEEYEEEEQ---EEAAVEEQEEAAEEDAEAEAETEETRAEED----EEEEEAKEA 55
++ E E E+EEQ +E + EQEE E E EE E++ E+E++ ++
Sbjct: 336 ELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQ 395
Query: 56 EDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKK 115
E+ E+ + ++ + E++ ++ + + R EK + E E + +
Sbjct: 396 EERMWEQDERLREK------EERMREQEKM-WEQVEKMREEKKMQEQ--------EKKTR 440
Query: 116 EEEELVSLKDRI-ERRRAERAEQQRIRNEREKE---------------RQNRLAEERARR 159
++EE + ++RI ER + R E++ +R + EK +Q RL E++ +
Sbjct: 441 DQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 500
Query: 160 EEEENRRKAEDEA-RKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKV 218
E+E ++ E++ +++ + + G +K + E+ + E+++K+ + +K+
Sbjct: 501 WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 560
Query: 219 LAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNR 267
+ E + +E+ K+ W + E+ ++E+ K+ + E ++R +
Sbjct: 561 WDQEERMEKKTQEQEKKTWDQEEKMREEE-RMREREKKMREEEEMMREQ 608
Score = 48.9 bits (115), Expect = 5e-06
Identities = 52/252 (20%), Positives = 114/252 (45%), Gaps = 18/252 (7%)
Query: 25 EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKI--PDG 82
EE +++AE + + +E+ E + KE + +E +K N + ++ +
Sbjct: 221 EELKKKNAELQEKLPLAESEKSEIQLNVKELKR-KLERAKFLLPQVQTNTLQEEMWRQEE 279
Query: 83 ERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRN 142
E + + RK+ EK + + L E + R++EE+ K E+ + R +++ +R
Sbjct: 280 ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELRE 339
Query: 143 EREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQ 202
++E Q +E+ + E+ + E E + + + +++Q Q R +R
Sbjct: 340 QKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERM 399
Query: 203 TEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNL-EAEKFDLQEKFKQQKYEI 261
E++++ L E+ E+++RE+ K +W+ + + E +K QEK + + E
Sbjct: 400 WEQDER---LREK----------EERMREQEK-MWEQVEKMREEKKMQEQEKKTRDQEEK 445
Query: 262 NVLRNRINDNQK 273
RI + +K
Sbjct: 446 MQEEERIREREK 457
Score = 48.1 bits (113), Expect = 9e-06
Identities = 45/181 (24%), Positives = 79/181 (43%), Gaps = 12/181 (6%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEE--EEEAKEAEDG 58
M + E + E ++ +EE + EQEE +E E E EE E++E+ E+E K E
Sbjct: 709 MREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ 768
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKR-MEKDLNELQALIEAHFENRKKEE 117
+ E K K KI + E D + R E+ + + + E +E
Sbjct: 769 RLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQE 828
Query: 118 EELVSLKDRI---------ERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKA 168
E++ ++++ + + E Q + RE+E + R EE+ R +EE+ R +
Sbjct: 829 EKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQE 888
Query: 169 E 169
E
Sbjct: 889 E 889
Score = 41.6 bits (96), Expect = 8e-04
Identities = 39/191 (20%), Positives = 93/191 (48%), Gaps = 18/191 (9%)
Query: 90 IHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQ 149
I + ++K ELQ + + + + + LK ++ER + + Q + E RQ
Sbjct: 218 ITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ 277
Query: 150 NRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREK-- 207
EE R +E++ R++ E R+++ L G +++Q + + KR E+EK
Sbjct: 278 ----EEELREQEKKIRKQEEKMWRQEERLREQ---EGKMREQEEKMWRQEKRLREQEKEL 330
Query: 208 --KKKILAERRKVLAIDHLNEDQLREKAKELW---QSIYNLEAEKFDLQEKFKQQKYEIN 262
++K L E++++ E+Q++E+ +++W + + E + + +E+ +Q+ ++
Sbjct: 331 REQEKELREQKEL----REQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 386
Query: 263 VLRNRINDNQK 273
++ D ++
Sbjct: 387 EQEQKMRDQEE 397
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 72.4 bits (176), Expect = 4e-13
Identities = 69/288 (23%), Positives = 125/288 (43%), Gaps = 17/288 (5%)
Query: 9 EEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAE---DGPMEESKP 65
E ++E+E ++ E E E +TE+ +E E E +E E + + +
Sbjct: 172 ERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRE 231
Query: 66 KPRSFMPNLVPPKIPDGERVDFDDIHR-KRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ R K + ER + R K E++ + + + R+KE E K
Sbjct: 232 RDRQRKTEREREKQAERERASERETERDKERERERDR-----DRDRDRRQKERERQTDRK 286
Query: 125 --DRIER-RRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNM 181
R ER R ER +++ ERE+ER + ER R E E +R+ E + K++
Sbjct: 287 RQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRK 346
Query: 182 MHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE---LWQ 238
++ QT R+ G+RQ ERE++++ +R+ + D+ R++ KE +
Sbjct: 347 RQTEMDRERNRQTGRE-GRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTE 405
Query: 239 SIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGR 286
+ + E +E+ K ++ E R R + QK + R + + T R
Sbjct: 406 KDRDGQRETEKQREREKDRESERGRERGREREKQK-GRERDRERQTDR 452
Score = 59.7 bits (143), Expect = 3e-09
Identities = 54/264 (20%), Positives = 123/264 (46%), Gaps = 23/264 (8%)
Query: 9 EEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPR 68
E + E+E +E+E E + E + + E E + +A++ + + + + R
Sbjct: 112 ERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERE--RQTDRERQR 169
Query: 69 SFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIE 128
N + + R + + R+R +++ E + H E ++ E E + +
Sbjct: 170 QTERNRQKEREREKNRQERRERERQREKENKTE-----DRHSERGRERERERETETETER 224
Query: 129 RRRAERAEQQRIRNEREKERQ---NRLAEERARREEEENRRKAEDEARKKKALSNMMHFG 185
+R+ +R ++ + ERE+E+Q R +E R++E R + D R ++
Sbjct: 225 KRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQK------- 277
Query: 186 GYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAID-HLNEDQLREKAKELWQSIY-NL 243
+++ QT+RK +R+TER+++ + ER++ + N + RE+ +E +
Sbjct: 278 ---ERERQTDRKR-QRRTERDRETERKRERQRERERERERNRKRERERERERERERQRET 333
Query: 244 EAEKFDLQEKFKQQKYEINVLRNR 267
E ++ +E+ ++++ E++ RNR
Sbjct: 334 ERDREKERERKRKRQTEMDRERNR 357
Score = 59.3 bits (142), Expect = 4e-09
Identities = 56/272 (20%), Positives = 110/272 (40%), Gaps = 31/272 (11%)
Query: 12 EEEEQEEAAVEEQEEAAEEDAEAEAETE-ETRAEEDEEEEEAKEAEDGPMEESKPKPRSF 70
+E + + ++A +D E + E E R E+ + E E + E+ + + R
Sbjct: 34 QESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKR-- 91
Query: 71 MPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERR 130
D HR+R E + + + ++++E ++R R
Sbjct: 92 ------------------DRHRERQRDREKERERQTDRERDRQREKERNRQKERERETER 133
Query: 131 RAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAE----DEARKKKALSNMMHFGG 186
ER ++ +RE+ERQ +ER R+ + E +R+ E E ++K
Sbjct: 134 EGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERER 193
Query: 187 YIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAE 246
+K+ +TE + +R ERE++++ E + D D+ R+ +E +AE
Sbjct: 194 QREKENKTEDRHSERGRERERERETETETERKRQTDR-ERDRQRKTERE-----REKQAE 247
Query: 247 KFDLQEKFKQQKYEINVLRNRINDNQKVSKTR 278
+ E+ ++ E R+R D + K R
Sbjct: 248 RERASERETERDKERERERDRDRDRDRRQKER 279
Score = 58.2 bits (139), Expect = 8e-09
Identities = 47/195 (24%), Positives = 87/195 (44%), Gaps = 18/195 (9%)
Query: 13 EEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMP 72
++E+E +++ E D E E + E R E E E K + E + + R
Sbjct: 276 QKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQR---- 331
Query: 73 NLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRA 132
+ ER + RKR + + + + E R++ E E ++R +
Sbjct: 332 --------ETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAR 383
Query: 133 ERAEQQRIRN-EREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQ 191
ER E++R R+ +R+KER+ + ++R + E E +R+ E + ++ G +KQ
Sbjct: 384 EREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRER----GREREKQ 439
Query: 192 AQTERKSGKRQTERE 206
ER +RQT+R+
Sbjct: 440 KGRERDR-ERQTDRQ 453
Score = 53.9 bits (128), Expect = 2e-07
Identities = 45/206 (21%), Positives = 94/206 (45%), Gaps = 8/206 (3%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAE---DGPME 61
E E +E E+E +++ +E + R E D E E +E + + E
Sbjct: 253 ERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERE 312
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
++ + R + + ER + RKR + + + + E R++ E E
Sbjct: 313 RNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERE 372
Query: 122 SLKDRIERRRAERAEQQRIRN-EREKERQNRLAEER-ARREEEENRRKAED---EARKKK 176
++R + ER E++R R+ +R+KER+ + ++R +RE E+ R + +D E +++
Sbjct: 373 RERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRER 432
Query: 177 ALSNMMHFGGYIQKQAQTERKSGKRQ 202
G ++ QT+R++G+++
Sbjct: 433 GREREKQKGRERDRERQTDRQAGRQR 458
Score = 53.1 bits (126), Expect = 3e-07
Identities = 51/208 (24%), Positives = 90/208 (43%), Gaps = 13/208 (6%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
E+ E E+E +E+E + D + + +E + D + + E D E +
Sbjct: 243 EKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE-RDRETERKR 301
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ R + + ER R+R + E + E E ++K + E+ +
Sbjct: 302 ERQRERERERERNRKRERER------ERERERERQRETERDREKERERKRKRQTEMDRER 355
Query: 125 DRIERRRAER-AEQQRIRNEREKERQNRLAEERARREEEENR-RKAEDEARKKKALSNMM 182
+R R R AE++R ERE+ER + A ER RE + +R R+ E E + +K
Sbjct: 356 NRQTGREGRRQAERER---ERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQR 412
Query: 183 HFGGYIQKQAQTERKSGK-RQTEREKKK 209
+++ E + G+ R EREK+K
Sbjct: 413 ETEKQREREKDRESERGRERGREREKQK 440
Score = 50.1 bits (118), Expect = 2e-06
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 17/169 (10%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+ E E E E+E ++E E + E E + E R E E E + K + E
Sbjct: 296 ETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRER 355
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
++ R + + ER R+ E+D + +R+KE E
Sbjct: 356 NRQTGREGRRQAERERERERERDRQSAREREERERDRDR----------DRQKERERQTE 405
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDE 171
KDR +R E+ + EREK+R++ ER R E++ R+ + E
Sbjct: 406 -KDRDGQRETEK------QREREKDRESERGRERGREREKQKGRERDRE 447
Score = 39.7 bits (91), Expect = 0.003
Identities = 41/165 (24%), Positives = 75/165 (45%), Gaps = 13/165 (7%)
Query: 132 AERAEQQRIRN-EREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQK 190
A+ +++R R ERE+ R+ R E R+ E RR+ +D RK+ ++
Sbjct: 49 ADGDDRERNRQKERERRREKRQTERETDRKRE--RRREKDRHRKRDRHRERQR-DREKER 105
Query: 191 QAQTER-------KSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNL 243
+ QT+R K RQ ERE++ + ER + D E + + A++ + +
Sbjct: 106 ERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDR 165
Query: 244 EAEKFDLQEKFKQQKYEIN--VLRNRINDNQKVSKTRGKAKVTGR 286
E ++ + + K+++ E N R R +K +KT + GR
Sbjct: 166 ERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGR 210
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 72.4 bits (176), Expect = 4e-13
Identities = 64/279 (22%), Positives = 131/279 (46%), Gaps = 33/279 (11%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE----EEEEAKEAEDGP 59
++E EE + EE+E+ +EQE E+ + + E E+ EE E +E E + +D
Sbjct: 906 LQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKK 965
Query: 60 MEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKE--- 116
+++ + + L+ + R + + +R+ E E Q L E + R++E
Sbjct: 966 LQQKEEQ-------LLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWER 1018
Query: 117 ----------EEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRR 166
EEE + ++R +RR ER Q R E ++E + L EER R +E R
Sbjct: 1019 QYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078
Query: 167 KAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAE-----RRKVLAI 221
+ E ++ ++ +++ + ER+ + + +++++++L E RR+ L
Sbjct: 1079 QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138
Query: 222 DHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYE 260
+ E++++++ ++L + E EK QE +Q + E
Sbjct: 1139 QYREEEEVQQEEEQLLRE----EPEKRRRQELERQYREE 1173
Score = 71.6 bits (174), Expect = 7e-13
Identities = 65/289 (22%), Positives = 139/289 (48%), Gaps = 33/289 (11%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEE-----DAEAEAETEETRAEEDEEEEEAKEAED 57
+++E E+ + E++E E QEE ++ + + + EE R E+ EE E +E +
Sbjct: 270 ELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE 329
Query: 58 GPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKE- 116
E + + R ++ R+ E++ E Q E E R+++
Sbjct: 330 QQEERREQQLRREQEERREQQL------------RREQEEERREQQLRREQEEERREQQL 377
Query: 117 -EEELVSLKDRIERRRAERAEQ-----QRIRNEREKERQNRL-AEERARREEEENR--RK 167
E+ + + ++ R + R EQ Q++R E++ R+ +L E++ RRE+EE R +K
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK 437
Query: 168 AEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNED 227
E E R+++ +++++ +TER +R+ ++ K+ + R + L L E+
Sbjct: 438 HEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL---KLEEE 494
Query: 228 QLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSK 276
+ RE+ + Q + + E+ +++ K+Q+ E L+ R+ Q++ +
Sbjct: 495 ERREQQERREQQLRREQEER--REQRLKRQEEE-ERLQQRLRSEQQLRR 540
Score = 70.9 bits (172), Expect = 1e-12
Identities = 61/287 (21%), Positives = 138/287 (48%), Gaps = 15/287 (5%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE E+ E+E+ E ++ ++E + + E ETE R E++ +++ K ++ E
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETE--RHEQERRKQQLKRDQEEERRERW 488
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNE--LQALIEAHFENRKKEEEELVS 122
K + R + ++ +R+++ E LQ + + + R+++EE
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 123 LKDRIERRRAER-AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNM 181
L R E +R E+ +QR++ E+E+ R L E RR++ R K E E R ++ L
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ---RLKREQEERLEQRLKR- 604
Query: 182 MHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIY 241
++++ + E++ + + E E+++++L + + + QLR + +E +
Sbjct: 605 -EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ----EERRQQQLRREQQERREQRL 659
Query: 242 NLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 288
E E+ L+++ K++ E + + Q+ ++ R K+++ +W+
Sbjct: 660 KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIP-KWQ 705
Score = 70.9 bits (172), Expect = 1e-12
Identities = 69/312 (22%), Positives = 139/312 (44%), Gaps = 54/312 (17%)
Query: 5 EEVVEEYEE----EEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE------------E 48
EE +++ EE EE+E+ +E+E +D + + + E+ EE E E
Sbjct: 933 EEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYRE 992
Query: 49 EEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEA 108
EEE ++ E+ + E + K R R +++ +RK+ E E Q L E
Sbjct: 993 EEELQQEEEQLLREEREKRR---------------RQEWERQYRKKDELQQEEEQLLREE 1037
Query: 109 HFENRKKE-------------EEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEE 155
+ R +E EEE + ++R RRR E Q R E ++E + L EE
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097
Query: 156 RARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAE- 214
+R +E R+ +E ++ ++ +++ + ER+ + + +++++++L E
Sbjct: 1098 PEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREE 1157
Query: 215 ----RRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRIND 270
RR+ L + E++L+++ ++L + E ++ QE+ +Q + E + R +
Sbjct: 1158 PEKRRRQELERQYREEEELQQEEEQLLR-----EEQEKRRQERERQYREEEELQRQKRKQ 1212
Query: 271 NQKVSKTRGKAK 282
+ R K
Sbjct: 1213 RYRDEDQRSDLK 1224
Score = 70.5 bits (171), Expect = 2e-12
Identities = 62/260 (23%), Positives = 122/260 (46%), Gaps = 29/260 (11%)
Query: 13 EEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE----EEEEAKEAEDGPMEESKPKPR 68
+EE+EE EE+E+ ++ E + EE +E+E EE E + ++ + K K
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966
Query: 69 SFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIE 128
+ + P+ R R+ EK E E ++EEE + ++R +
Sbjct: 967 QQKEEQLLGEEPEKRR-------RQEREKKYRE---------EEELQQEEEQLLREEREK 1010
Query: 129 RRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYI 188
RRR E Q R ++E ++E + L EER +R +E R+ +E ++ ++
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET 1070
Query: 189 QKQAQTERKSGKRQTEREKKKKILAE-----RRKVLAIDHLNEDQLREKAKELWQSIYNL 243
+++ + ER+ K + +++++++L E RR+ E++L+++ ++L +
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE---- 1126
Query: 244 EAEKFDLQEKFKQQKYEINV 263
E EK QE +Q + E V
Sbjct: 1127 EREKRRRQELERQYREEEEV 1146
Score = 69.3 bits (168), Expect = 4e-12
Identities = 61/246 (24%), Positives = 120/246 (48%), Gaps = 33/246 (13%)
Query: 9 EEYEEEEQEEAAVEEQEEAAE--EDAEAEAETEET-RAEEDEEEEEAKEAEDGPMEESKP 65
++ +E+E+E A EEQ E E E + + EE R ++ +E E + AE+ ++ K
Sbjct: 139 QKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKG 198
Query: 66 KPRSFMPN---LVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENR----KKEEE 118
P+ L ++ + R ++ ++R E+ Q E + R +KEEE
Sbjct: 199 HETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE 258
Query: 119 ELVSLKDRIER---------RRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAE 169
+L + + +R R+ ER E +R R E E+++Q E++ RR++EE RR+ +
Sbjct: 259 KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318
Query: 170 DEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQL 229
+E R+++ +++ Q ER+ + + E+E++++ R + + E QL
Sbjct: 319 EERREQQE-----------RREQQEERREQQLRREQEERREQQLRREQE---EERREQQL 364
Query: 230 REKAKE 235
R + +E
Sbjct: 365 RREQEE 370
Score = 68.6 bits (166), Expect = 6e-12
Identities = 57/291 (19%), Positives = 132/291 (45%), Gaps = 16/291 (5%)
Query: 9 EEYEEEEQ--EEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEA-----EDGPME 61
EE+ +EEQ +E + + EE + E ++ +E+EE+E K E+ ++
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKD-----LNELQALIEAHFENRKKE 116
E +P+ + + + +++ ++ R+R E++ L Q L E R+++
Sbjct: 262 EEEPQRQRELQE----EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317
Query: 117 EEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKK 176
+EE ++R E++ R +Q R E +E+Q R +E RRE++ R + E+ ++
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL 377
Query: 177 ALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKEL 236
+ ++++ Q R+ R+ ++ ++++ L +++ L +Q E+ ++
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK 437
Query: 237 WQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRW 287
+ + K + +E+ K E R+ ++ K + + RW
Sbjct: 438 HEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Score = 67.8 bits (164), Expect = 1e-11
Identities = 63/271 (23%), Positives = 126/271 (46%), Gaps = 28/271 (10%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETE-------ETRAEEDEEEEEAKEA 55
++++ E+ EE+E+ ++E+E E+ E + E E ETR ++ E + KE
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE 1084
Query: 56 EDGPMEES--KPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENR 113
E EE + +P + + E + ++ R E++ Q L + E
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEE 1144
Query: 114 KKEEEELVSLKDRIERRRAERAEQQ-RIRNEREKERQNRLAEERARREEEENRRKAEDEA 172
+ ++EE L++ E+RR + E+Q R E ++E + L EE+ +R +E R+ E+E
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEE 1204
Query: 173 RKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKK-----KKILAERRKVLAIDHLNED 227
+++ + + + +R K Q E EK+ K+ + R+ L +
Sbjct: 1205 LQRQKRKQ--------RYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS 1256
Query: 228 QLREKAKELWQSIYNLEAEKFDLQEKFKQQK 258
QLR++ + Q + +L E+ QE+ ++Q+
Sbjct: 1257 QLRDRQSQ--QDLQHLLGEQ---QERDREQE 1282
Score = 67.0 bits (162), Expect = 2e-11
Identities = 63/271 (23%), Positives = 133/271 (49%), Gaps = 27/271 (9%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKE------AEDG 58
E + E +++E+ + E+EE + + +E + E+EE+ + +E E+
Sbjct: 795 ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEED 854
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRK--KE 116
++E + + RS + R ++ RKR L AL E + ++ +E
Sbjct: 855 GLQEDQERRRS-----QEQRRDQKWRWQLEE-ERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 117 EEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKK 176
EEE + ++R +RRR E+ Q R + ++E + L EER +R +E R+ + + ++
Sbjct: 909 EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ 968
Query: 177 ALSNMMHFGGYIQKQAQTERKSGKRQTE--REKKKKILAE-----RRKVLAIDHLNEDQL 229
++ G +K+ + ER+ R+ E +++++++L E RR+ + +D+L
Sbjct: 969 KEEQLL--GEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDEL 1026
Query: 230 REKAKELWQSIYNLEAEKFDLQEKFKQQKYE 260
+++ ++L + E EK LQE+ +Q + E
Sbjct: 1027 QQEEEQLLRE----EREKRRLQERERQYREE 1053
Score = 63.5 bits (153), Expect = 2e-10
Identities = 60/279 (21%), Positives = 125/279 (44%), Gaps = 16/279 (5%)
Query: 11 YEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEE----EAKEAEDGPMEESKPK 66
++EEE++E E EE+ E E + R ++EEE+ E +E EE + +
Sbjct: 238 FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQ 297
Query: 67 PRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDR 126
R + K + R ++ ++ ++ E + + E ++ E++L ++
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE 357
Query: 127 IERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRR----KAEDEARKKKAL--SN 180
R + R EQ+ R E++ R+ +L E+ R E++ RR + E + R+++ L
Sbjct: 358 ERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 417
Query: 181 MMHFGGYIQKQAQTERKSGKRQTER--EKKKKILAERRKVLAIDHLNEDQLREKAKELWQ 238
+ ++++ + ER K + ER ++ K+ ERR L + E +E+ K+ +
Sbjct: 418 QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK 477
Query: 239 SIYNLEAE----KFDLQEKFKQQKYEINVLRNRINDNQK 273
E K + +E+ +QQ+ LR + ++
Sbjct: 478 RDQEEERRERWLKLEEEERREQQERREQQLRREQEERRE 516
Score = 63.5 bits (153), Expect = 2e-10
Identities = 57/255 (22%), Positives = 121/255 (47%), Gaps = 13/255 (5%)
Query: 6 EVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKP 65
+V ++E + E++E+ ++E + + EE + +EEE+ ++ E K
Sbjct: 718 KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKS 777
Query: 66 KPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKD 125
+ + PP ER + ++R ++ L E + E R++ E+EL L++
Sbjct: 778 ERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK-EQRRRQRREREKELQFLEE 836
Query: 126 RIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFG 185
+ +R ERA+Q + + +E Q R + RR+++ + E+ R++ L
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ 896
Query: 186 GYIQKQAQ--TERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNL 243
++K+ Q E + ++ EREK+++ ER+ + E+QL+++ ++L +
Sbjct: 897 EQLRKEQQLLQEEEEELQREEREKRRRQEQERQ------YREEEQLQQEEEQLLRE---- 946
Query: 244 EAEKFDLQEKFKQQK 258
E EK QE+ +Q +
Sbjct: 947 EREKRRRQERERQYR 961
Score = 63.2 bits (152), Expect = 3e-10
Identities = 51/255 (20%), Positives = 121/255 (47%), Gaps = 29/255 (11%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
E+ + ++ +E+ EQ+ E+ E + + EE E++ +E + ++ +
Sbjct: 392 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNE--LQALIEAHFENRKKEEEELVS 122
+ R ++ + + ER ++++++D E + ++ E R++++E
Sbjct: 452 EERRDWLKREEETERHEQER------RKQQLKRDQEEERRERWLKLEEEERREQQERR-- 503
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
+ ++ R + ER EQ+ R E E+ Q RL E+ R E+E RR ++ K++
Sbjct: 504 -EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERR---EQLLKREE----- 554
Query: 183 HFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYN 242
+K+ + ER+ + + E+E+++ L +R + + + RE+ + L Q +
Sbjct: 555 ------EKRLEQERREQRLKREQEERRDQLLKREE----ERRQQRLKREQEERLEQRLKR 604
Query: 243 LEAEKFDLQEKFKQQ 257
E E+ + +E+ +Q+
Sbjct: 605 EEVERLEQEERREQR 619
Score = 63.2 bits (152), Expect = 3e-10
Identities = 67/284 (23%), Positives = 122/284 (42%), Gaps = 50/284 (17%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEE-----------TRAEEDEEEEEA 52
+EE ++E +E+ EQEE E+ + + E E R +E+ E+
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Query: 53 KEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFEN 112
K E+ +E+ + + R K ER D + ++ E+ L+ E E
Sbjct: 551 KREEEKRLEQERREQRL--------KREQEER--RDQLLKREEERRQQRLKREQEERLEQ 600
Query: 113 RKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEA 172
R K EE +R+E+ ER EQ+ R E E+ER+ +L + + E + + + E +
Sbjct: 601 RLKREE-----VERLEQE--ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653
Query: 173 RKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREK 232
R+++ L +++ + + KR+ E E++++ LAE ++Q RE+
Sbjct: 654 RREQRLKR--------EEEEERLEQRLKREHEEERREQELAEE---------EQEQARER 696
Query: 233 AKE---LWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQK 273
K WQ + LE+E Q K + + R R +K
Sbjct: 697 IKSRIPKWQ--WQLESEADARQSKVYSRPRKQEGQRRRQEQEEK 738
Score = 62.8 bits (151), Expect = 3e-10
Identities = 61/272 (22%), Positives = 126/272 (46%), Gaps = 30/272 (11%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
+E+ +Y +EE+ + +E+E+ E+ E E R + EEEE ++ E+ + E +
Sbjct: 1074 QELERQYRKEEELQ---QEEEQLLREEPEKRRRQERER--QCREEEELQQEEEQLLREER 1128
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
K R + + + E V ++ R E + Q L + E + ++EE L+
Sbjct: 1129 EKRRR---QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185
Query: 125 DRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHF 184
+ E+RR ER +++ R E E +RQ R ++R R E++ + K + E K+ A+
Sbjct: 1186 EEQEKRRQER--ERQYREEEELQRQKR--KQRYRDEDQRSDLKWQWEPEKENAV------ 1235
Query: 185 GGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHL---NEDQLREKAKELWQSIY 241
+ + K + + R+ + L +R+ + HL +++ RE+ + WQ
Sbjct: 1236 -----RDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQ-- 1288
Query: 242 NLEAEKFDLQEKFKQQKYEINVLRNRINDNQK 273
F +E+ ++++ + R+R + +K
Sbjct: 1289 --RDRHFPEEEQLEREEQKEAKRRDRKSQEEK 1318
Score = 62.4 bits (150), Expect = 4e-10
Identities = 65/272 (23%), Positives = 129/272 (47%), Gaps = 22/272 (8%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
+E ++ EEEQ+ E + + EE+ + E EE++ +E +E + E
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE--- 1482
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKK---EEEELV 121
+ R F+ + + +R F + + E + L+ + H + R++ +EE+ +
Sbjct: 1483 -RDRKFLEEEQQLRRQERDR-KFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQL 1540
Query: 122 SLKDRIERRRAER----AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKA 177
++R ++RR +R E++++R ERE+++ +R +R R EE+ R+ E E + +
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600
Query: 178 LSNMMHFGGYIQKQAQTERKSGKRQ---TEREKKKKILAER-RKVLAIDHLNEDQLREKA 233
+ G Q + + +RK + + ERE+++ ER RK L E QLR +
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE----EEPQLRRQE 1656
Query: 234 KELWQSIYNLEAEKFDLQEKFKQQKYEINVLR 265
+E Q + + KF +E+ Q+ E + R
Sbjct: 1657 RE--QQLRHDRDRKFREEEQLLQEGEEQQLRR 1686
Score = 61.2 bits (147), Expect = 1e-09
Identities = 70/323 (21%), Positives = 143/323 (44%), Gaps = 54/323 (16%)
Query: 9 EEYEEEEQEEAA-----VEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEES 63
E+ E EEQ+EA +E+++ E+ E + +ET + EEE+ +E E+ P+
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 64 K-------------PKPRSFMPNLVPPKIPDGERVDFDD------------IHRKRMEKD 98
+ + R F+ + + ER + + + R K
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKF 1416
Query: 99 LNELQALIEAHFENRKKEEEELVSLKDRI------------ERRRAERAEQQRIRNEREK 146
E Q L + + +EEE+ V ++R ER R R E+Q ++ E+
Sbjct: 1417 REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ 1476
Query: 147 ERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTERE 206
+ + + + EE++ RR+ D +++ L + +++++ Q R+ +R+ +E
Sbjct: 1477 QLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQE 1536
Query: 207 KKKKILAERRKVLAIDH----LNEDQLREKAKELWQSIYNLEAE-KFDLQE-KFKQQKYE 260
+++ ER + D E+QLR++ +E Q + E + KF L+E K ++Q+ E
Sbjct: 1537 EQQLRRQERGQQRRQDRDRKFREEEQLRQEREE--QQLSRQERDRKFRLEEQKVRRQEQE 1594
Query: 261 INVLRNRINDNQKVSKTRGKAKV 283
R + D Q++ + G+ ++
Sbjct: 1595 ----RKFMEDEQQLRRQEGQQQL 1613
Score = 58.9 bits (141), Expect = 5e-09
Identities = 73/296 (24%), Positives = 132/296 (44%), Gaps = 51/296 (17%)
Query: 12 EEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFM 71
EEE +++ EQEE E+ + E E R E++E E+ + E+ E + +S
Sbjct: 582 EEERRQQRLKREQEERLEQRLKRE---EVERLEQEERREQRLKREEPEEERRQQLLKSEE 638
Query: 72 PNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEE---EELVSLKDRIE 128
+ E+ + + KR E++ Q L H E R+++E EE ++RI+
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK 698
Query: 129 RR---------------------RAERAEQQRIRNEREKERQNRLAE------ERA-RRE 160
R R + E QR R E+E++R+ R +E ERA R++
Sbjct: 699 SRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758
Query: 161 EEENRRK--------AEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQ------TERE 206
+EE +R+ E R ++ LS ++Q + E + + Q E+E
Sbjct: 759 QEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKE 818
Query: 207 KKKKILAERRKVLA-IDHLNEDQLREKAKELWQSIYNL--EAEKFDLQEKFKQQKY 259
++++ ER K L ++ + Q RE+A++L + L + E+ QE+ + QK+
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874
Score = 58.9 bits (141), Expect = 5e-09
Identities = 63/282 (22%), Positives = 124/282 (43%), Gaps = 58/282 (20%)
Query: 9 EEYEEEEQEEAAVEEQE------EAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
EE EE Q++ E+QE + EE+ E + EE E+E A+E ++ E
Sbjct: 637 EEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARER 696
Query: 63 SKPKPRSFMPNLVP------------PKIPDGERVDFDDIHRKRMEKDLNELQALIEAHF 110
K + + L P+ +G+R + ++R + +ELQ E
Sbjct: 697 IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE--SELQWQEEERA 754
Query: 111 ENRKKEEEELVSL------KDRIERRRAERAEQQRIRNEREK-----ERQNRLAEERARR 159
+++EEE+ +++ ER R + + +R +RE+ ERQ R E+R
Sbjct: 755 HRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR--EQRFLP 812
Query: 160 EEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVL 219
EEEE ++ ++K L +++++ Q +R+ +Q + E+
Sbjct: 813 EEEEKEQRRRQRREREKELQ-------FLEEEEQLQRRERAQQLQEEE------------ 853
Query: 220 AIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEI 261
D L EDQ R +++E + + ++ L+E+ K++++ +
Sbjct: 854 --DGLQEDQERRRSQEQRRD----QKWRWQLEEERKRRRHTL 889
Score = 58.5 bits (140), Expect = 6e-09
Identities = 60/265 (22%), Positives = 126/265 (47%), Gaps = 46/265 (17%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEA---ETEETRAEEDEEEEEAKEAEDGPME 61
E+ + +EE +E+ E+E+ E++ + E EE R + + EEE ++ +
Sbjct: 535 EQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ 594
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
E + + R K + ER++ ++ +R++++ E E + K EE+
Sbjct: 595 EERLEQRL--------KREEVERLEQEERREQRLKREEPE-----EERRQQLLKSEEQEE 641
Query: 122 SLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRR-----KAEDEARKKK 176
+ ++ R + ER E QR++ E E+ER E+R +RE EE RR + E E +++
Sbjct: 642 RRQQQLRREQQERRE-QRLKREEEEER----LEQRLKREHEEERREQELAEEEQEQARER 696
Query: 177 ALSNMMHFGGYIQKQA---QTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKA 233
S + + ++ +A Q++ S R+ E +++++ E+R+ R ++
Sbjct: 697 IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR------------RRES 744
Query: 234 KELWQSIYNLEAEKFDLQEKFKQQK 258
+ WQ E E+ Q++ ++Q+
Sbjct: 745 ELQWQ-----EEERAHRQQQEEEQR 764
Score = 57.8 bits (138), Expect = 1e-08
Identities = 58/289 (20%), Positives = 136/289 (47%), Gaps = 30/289 (10%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEES 63
+EE + + ++ Q + EEQ+ +E + + + + E+E+ + +E + +E
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE- 1576
Query: 64 KPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSL 123
+ R F + + ER +D + R ++ +L+ + F +E+E+L+
Sbjct: 1577 --RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF----REDEQLLQE 1630
Query: 124 KDRIERRRAER-----AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDE------- 171
++ + R ER E+ ++R + E+E+Q R +R REEE+ ++ E++
Sbjct: 1631 REEQQLHRQERDRKFLEEEPQLRRQ-EREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER 1689
Query: 172 ----ARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDH---- 223
+++ L ++Q++ Q R+ +R+ E++ + E+ ++ +
Sbjct: 1690 DRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI 1749
Query: 224 LNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQ 272
L E+QLR + +E Q + E ++ +E+ +Q+ E LR++ +D +
Sbjct: 1750 LEEEQLRPEREE--QQLRRQERDRKFREEEQLRQEREEQQLRSQESDRK 1796
Score = 57.4 bits (137), Expect = 1e-08
Identities = 63/263 (23%), Positives = 114/263 (43%), Gaps = 25/263 (9%)
Query: 12 EEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFM 71
E+EE+ E ++ QEE +E + R +E+ E+ K E+ +E+ + + R
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRL-- 567
Query: 72 PNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENR-KKEEEELVSLKDRIERR 130
K ER D + ++ E+ L+ E E R K+EE E + ++R E+R
Sbjct: 568 ------KREQEERRD--QLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQR 619
Query: 131 RA-----ERAEQQRIRNEREKER--------QNRLAEERARREEEENRRKAEDEARKKKA 177
E QQ +++E ++ER Q E+R +REEEE R + R+ +
Sbjct: 620 LKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE-ERLEQRLKREHEE 678
Query: 178 LSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELW 237
Q+QA+ KS + + + + + A + KV + E Q R + +E
Sbjct: 679 ERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEK 738
Query: 238 QSIYNLEAEKFDLQEKFKQQKYE 260
+ E + + + +QQ+ E
Sbjct: 739 RRRRESELQWQEEERAHRQQQEE 761
Score = 57.0 bits (136), Expect = 2e-08
Identities = 59/245 (24%), Positives = 111/245 (45%), Gaps = 32/245 (13%)
Query: 16 QEEAAVEEQEEAAEEDAEAEAETEETRAEE-DEEEEEAKEAEDGPMEESKPKPRSFMPNL 74
Q+ E+Q D + E E + R ++ E+E E E E+ ++ + + R
Sbjct: 111 QDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQR------ 164
Query: 75 VPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAER 134
D +R D +++ R+R E E + E ++ K E E D + RR E
Sbjct: 165 ------DRQRRD-EELWRQRQEWQEREERRAEEEQLQSCKGHETE--EFPDEEQLRRREL 215
Query: 135 AEQQRIRNEREKERQNRLAEERARREEEENR-RKAEDEARKKKALSNMMHFGGYIQKQAQ 193
E +R + EK++Q R ++R +EEEE RK E RK+ +++ Q
Sbjct: 216 LELRR-KGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKE-------------EEKLQ 261
Query: 194 TERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEK 253
E +R+ + E+++ ER++ L + E+Q +++ + Q E E+ + QE+
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQE-LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320
Query: 254 FKQQK 258
++Q+
Sbjct: 321 RREQQ 325
Score = 57.0 bits (136), Expect = 2e-08
Identities = 44/203 (21%), Positives = 95/203 (46%), Gaps = 14/203 (6%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
+E+ ++ EEEQ E+++ +E E E+ R E +E++ +E + EE +
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ 1778
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ L + D + + + + ++R E+ L Q + + + EEE + L+
Sbjct: 1779 LRQEREEQQLRSQE-SDRKFREEEQLRQEREEQQLRPQQR------DGKYRWEEEQLQLE 1831
Query: 125 DRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHF 184
++ +R R ER Q R + + ++R E+ +EEE+ RR+ + +++ +
Sbjct: 1832 EQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ--- 1888
Query: 185 GGYIQKQAQTERKSGKRQTEREK 207
QK+ Q R+ G+ +++ K
Sbjct: 1889 ----QKEEQRHRQVGEIKSQEGK 1907
Score = 56.6 bits (135), Expect = 2e-08
Identities = 66/290 (22%), Positives = 127/290 (43%), Gaps = 58/290 (20%)
Query: 10 EYEEEEQEEAAVEEQEEA--------AEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
+++EEE+ +E+E+ AEE +E + R E+ E AE+
Sbjct: 747 QWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR 806
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKK-----E 116
E + F+P E + + R+R E++ ELQ L E R++ +
Sbjct: 807 EQR-----FLP----------EEEEKEQRRRQRRERE-KELQFLEEEEQLQRRERAQQLQ 850
Query: 117 EEELVSLKDRIERRRAERAEQQRIRNEREKERQNRL----------------------AE 154
EEE +D+ RR E+ Q+ R + E+ER+ R E
Sbjct: 851 EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE 910
Query: 155 ERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAE 214
E +REE E RR+ E E R+ + + + ++ + +R+ +R+ + K KK+ +
Sbjct: 911 EELQREEREKRRRQEQE-RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK 969
Query: 215 RRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDL----QEKFKQQKYE 260
++L + E + R++ ++ ++ L+ E+ L +EK ++Q++E
Sbjct: 970 EEQLLGEE--PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017
Score = 54.7 bits (130), Expect = 9e-08
Identities = 68/314 (21%), Positives = 137/314 (43%), Gaps = 64/314 (20%)
Query: 3 DIEEVVEEYEEEEQEEAAV----------EEQEEAAEEDAEAEAETEETRAEEDE---EE 49
++E E EE +QEE + +E E E+ E + E E+ EE E +E
Sbjct: 1135 ELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQE 1194
Query: 50 EEAKEAEDGPMEESKPKPR--------------------SFMPNLVPPKIPDGE---RVD 86
E + E+ ++ K K R + N V K + E +++
Sbjct: 1195 RERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLE 1254
Query: 87 FDDIHRKRMEKDLNELQALIEAHFENRKKE------------EEELVSLKDRIERRRAER 134
+ ++ ++DL L L E +R++E EEE + +++ E +R +R
Sbjct: 1255 DSQLRDRQSQQDLQHL--LGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR 1312
Query: 135 ---AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQ 191
E+Q +R ERE++R+ + + + R EE+ + + E R+++ Q+Q
Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ 1372
Query: 192 AQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLRE----KAKELWQSIYNLEAEK 247
+ + +R +E+++K L E +++ + E QLR+ K +E Q + E ++
Sbjct: 1373 GRKFLEEEQRLRRQERERKFLKEEQQLRCQE--REQQLRQDRDRKFREEEQQLSRQERDR 1430
Query: 248 FDLQEKFKQQKYEI 261
KF++++ ++
Sbjct: 1431 -----KFREEEQQV 1439
Score = 54.7 bits (130), Expect = 9e-08
Identities = 51/231 (22%), Positives = 104/231 (45%), Gaps = 25/231 (10%)
Query: 12 EEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFM 71
E EEQ+ E + EE+ + + E + ++E++ +E E EE + + +
Sbjct: 1678 EGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQET-- 1735
Query: 72 PNLVPPKIPDGERVDFDDIHRKRMEKDL----NELQALIEAHFENRKKEEEELVSLKDRI 127
+ E++ + +RK +E++ E Q L + + +EEE+L ++
Sbjct: 1736 ---------EQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQ 1786
Query: 128 ERRRAER----AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMH 183
+ R E E++++R ERE+++ + R EEE + E E R ++
Sbjct: 1787 QLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR 1846
Query: 184 FGGYIQKQAQTERKSGKRQTE--REKKKKILAERRKVLAIDHLNEDQLREK 232
++Q T+ KS + + E +E+++K ER + L +H+ Q E+
Sbjct: 1847 ----AEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQ 1893
Score = 54.3 bits (129), Expect = 1e-07
Identities = 59/284 (20%), Positives = 127/284 (44%), Gaps = 36/284 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQ---EEAAEEDAEAEAETEETRAEEDE-------EEEEAKE 54
+E +Y EEE+ + +Q +E D + + E E+ A D E E+ ++
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQ 1252
Query: 55 AEDGPMEESKPKPR-SFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENR 113
ED + + + + + + + ER + R E++ E + EA +R
Sbjct: 1253 LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR 1312
Query: 114 KKEEEELVSLKDRIERRRAERA-----EQQRIRNEREKERQNRLAEERARREE-----EE 163
K +EE+ + ++R E+RR + E++++ ERE++ R +R REE E+
Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ 1372
Query: 164 NRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDH 223
R+ E+E R ++ +++++ Q + ++Q +++ +K E ++
Sbjct: 1373 GRKFLEEEQRLRRQERERK----FLKEEQQLRCQEREQQLRQDRDRKFREEEQQ------ 1422
Query: 224 LNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNR 267
L+ + K +E Q + E E+ KF +++ ++ R+R
Sbjct: 1423 LSRQERDRKFREEEQQVRRQERER-----KFLEEEQQLRQERHR 1461
Score = 52.8 bits (125), Expect = 4e-07
Identities = 55/250 (22%), Positives = 109/250 (43%), Gaps = 44/250 (17%)
Query: 11 YEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSF 70
+ EEEQ E EEQ+EA D +++ E + R E +E+ + EE + R
Sbjct: 1293 FPEEEQLER--EEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE 1350
Query: 71 MPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERR 130
P +R E+D + + + RK EEE R+ R+
Sbjct: 1351 QP-------------------LRRQERDRKFREEELRHQEQGRKFLEEE-----QRLRRQ 1386
Query: 131 RAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQK 190
ER + + R +ER+ +L ++R R+ EE ++ + E +K ++
Sbjct: 1387 ERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK------------FRE 1434
Query: 191 QAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDL 250
+ Q R+ + + E+++++ ER + E+QL ++ +E Q ++ E ++ L
Sbjct: 1435 EEQQVRRQERERKFLEEEQQLRQERHRKFR----EEEQLLQEREE--QQLHRQERDRKFL 1488
Query: 251 QEKFKQQKYE 260
+E+ + ++ E
Sbjct: 1489 EEEQQLRRQE 1498
Score = 51.2 bits (121), Expect = 1e-06
Identities = 63/275 (22%), Positives = 123/275 (44%), Gaps = 31/275 (11%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
+E+ +Y EEE+ + +E+E+ E+ E + E + E+EE + K + E+ +
Sbjct: 1164 QELERQYREEEELQ---QEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQR 1220
Query: 65 P---------KPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKK 115
K + N V K + E+ + + R + +LQ L+ E ++
Sbjct: 1221 SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDRE 1280
Query: 116 EEEELVSLKDRI--ERRRAERAEQQRI--RNEREKERQNRLAEERARREEEENRRKAEDE 171
+E +DR E + ER EQ+ R+ + +E + L EER EE+ RR+ D
Sbjct: 1281 QERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREER----EEKRRRQETD- 1335
Query: 172 ARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLRE 231
RK + ++ +++ Q R+ + + RE++ + + RK L + Q RE
Sbjct: 1336 -RKFREEEQLLQ-----EREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERE 1389
Query: 232 -KAKELWQSIYNLEAE---KFDLQEKFKQQKYEIN 262
K + Q + E E + D KF++++ +++
Sbjct: 1390 RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLS 1424
Score = 50.4 bits (119), Expect = 2e-06
Identities = 53/233 (22%), Positives = 105/233 (45%), Gaps = 39/233 (16%)
Query: 6 EVVEEYEEEEQEEAAVEEQEEAAEEDAEAE-AETEETRAEEDEEEEEAKEAEDGPMEESK 64
E ++ +E+E ++E+++ ++ E + E E+ R E ++E+ +E +EE +
Sbjct: 1695 EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+P L + D + + + + ++R E+ L ++ + + +EEE+L
Sbjct: 1755 LRPEREEQQLRRQE-RDRKFREEEQLRQEREEQQLRSQES------DRKFREEEQL---- 1803
Query: 125 DRIERRRAERAEQQRIRNEREKERQNRLAEE--RARREEEENRRKAEDEARKKKALSNMM 182
R ER + QQR R +E Q +L E+ R R+E + R E A ++K+
Sbjct: 1804 -RQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR--- 1859
Query: 183 HFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 235
++Q + + KR+ ERE+K L E+ +R + KE
Sbjct: 1860 ------EEQELWQEEEQKRRQERERK---------------LREEHIRRQQKE 1891
Score = 48.5 bits (114), Expect = 7e-06
Identities = 58/267 (21%), Positives = 119/267 (44%), Gaps = 35/267 (13%)
Query: 24 QEEAAEEDAEAEAETEETRAEEDEEEEEAK--EAEDGPMEESKPKPRSFMPNLVPPKIPD 81
Q +E+ A + +E+ ++ +EE+ + E D +EE + R ++ +
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150
Query: 82 GERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIR 141
GE + +E Q +E +R++ +EEL + + R RAE+++++
Sbjct: 151 GE--------------EQSEKQERLEQR--DRQRRDEELWRQRQEWQEREERRAEEEQLQ 194
Query: 142 NEREKERQNRLAEERARREE-EENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGK 200
+ + E + EE+ RR E E RRK +E ++++ F Q + E++ K
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVF------QEEEEKEWRK 248
Query: 201 RQT----EREKKKKILAERRKVL-----AIDHLNEDQLREKAKELWQSIYNLEAEKFDLQ 251
R+T E EK ++ +R++ L + L +LR + +E Q L E+ L+
Sbjct: 249 RETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQ-QLR 307
Query: 252 EKFKQQKYEINVLRNRINDNQKVSKTR 278
K ++++ E R + ++ + R
Sbjct: 308 RKQEEERREQQEERREQQERREQQEER 334
Score = 39.3 bits (90), Expect = 0.004
Identities = 39/175 (22%), Positives = 80/175 (45%), Gaps = 29/175 (16%)
Query: 82 GERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRI------ERRRAERA 135
G+ D+ R R + + LQ + R++E++ +DR +RRR +R
Sbjct: 90 GQATGLDEEKRARCDGKESLLQ-------DRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQ 142
Query: 136 EQQR--IRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQ 193
EQ+R E + E+Q RL E+R R+ +E + E ++++ +++A+
Sbjct: 143 EQERELAEGEEQSEKQERL-EQRDRQRRDEELWRQRQEWQERE------------ERRAE 189
Query: 194 TER-KSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEK 247
E+ +S K E + RR++L + ++ +++ +E ++ E EK
Sbjct: 190 EEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEK 244
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 72.0 bits (175), Expect = 6e-13
Identities = 61/228 (26%), Positives = 106/228 (46%), Gaps = 30/228 (13%)
Query: 10 EYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRS 69
E E E+E +E ++ E + + E E R E E+E + + + E K + R
Sbjct: 37 EIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERE 96
Query: 70 FMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIER 129
+ +GE + KR +K+ E + E +KE ER
Sbjct: 97 RKKRRREKENKEGEEKE------KRKKKEKKERGRTSKEGKERERKE-----------ER 139
Query: 130 RRAERAEQQRIRNEREKERQNRLAEERARR---EEEENRRKAEDEARKKKALSNMMHFGG 186
+R ER E++R + EREKER+ + ++R R+ E+EE R++ E + RKK+ +
Sbjct: 140 KREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERN------- 192
Query: 187 YIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAK 234
+K+ + ER+ K + ER+K++K ER+K D + +E+ K
Sbjct: 193 --RKERKKERER-KERRERKKERKKKEERKKERQKDRQTNWREKERGK 237
Score = 67.4 bits (163), Expect = 1e-11
Identities = 59/210 (28%), Positives = 101/210 (48%), Gaps = 37/210 (17%)
Query: 5 EEVVEEYEEEEQEEAAVEEQE-EAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEES 63
E+ E E+E + E +E++ E +E+ E + E +E EE+E+ K+ +E
Sbjct: 67 EKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKK------KEK 120
Query: 64 KPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSL 123
K + R+ + + +R + + RK+ E++ E + RKK E + V
Sbjct: 121 KERGRTSKEGKERERKEERKREERKERERKKEEREK-------ERERKERKKRERKQVGE 173
Query: 124 K--DRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNM 181
K +R E+ R ER +++R R ER+KER ER R E + RK ++E +K++
Sbjct: 174 KEEERKEKERKERKKRERNRKERKKER------ERKERRERKKERKKKEERKKER----- 222
Query: 182 MHFGGYIQKQAQT---ERKSGKRQTEREKK 208
QK QT E++ GKR+ + KK
Sbjct: 223 -------QKDRQTNWREKERGKRERKERKK 245
Score = 63.9 bits (154), Expect = 2e-10
Identities = 51/190 (26%), Positives = 95/190 (50%), Gaps = 15/190 (7%)
Query: 96 EKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERA-EQQRIRNEREK--ERQNRL 152
+ ++ E + IE E +K+ E E + E+R+ ER E++R R ++EK ER+
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 153 AEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKIL 212
E + RR E+EN+ E E RKKK G ++ + ERK +++ ER+++++
Sbjct: 95 RERKKRRREKENKEGEEKEKRKKKEKKER---GRTSKEGKERERKEERKREERKERERKK 151
Query: 213 AERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQ 272
ER K E + +E+ K + + E E+ + +E+ +++K E N + +
Sbjct: 152 EEREK--------ERERKERKKRERKQVGEKEEERKE-KERKERKKRERNRKERKKERER 202
Query: 273 KVSKTRGKAK 282
K + R K +
Sbjct: 203 KERRERKKER 212
Score = 28.9 bits (63), Expect = 5.5
Identities = 16/65 (24%), Positives = 28/65 (43%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEES 63
+ E EE +E+E++E E+ + E E + E ++EE KE +
Sbjct: 171 VGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNW 230
Query: 64 KPKPR 68
+ K R
Sbjct: 231 REKER 235
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 71.6 bits (174), Expect = 7e-13
Identities = 63/278 (22%), Positives = 139/278 (50%), Gaps = 26/278 (9%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEED----EEEEEAKEAEDGP 59
I+E E+ +E+E++ + EQEE E E EE ++ E+EE+ +E E+
Sbjct: 297 IQEREEKIQEQEEK---IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 353
Query: 60 MEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEE 119
E+ K + + KI + E+ + R E+ + E + I E +++EE+
Sbjct: 354 HEQEKIREQE-EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEK 412
Query: 120 LVSLKDRIERRRAERAEQ-QRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKAL 178
+ ++++ + E EQ +++R + EK R+ +E+ RE+EE R+ E+ ++++
Sbjct: 413 MGEQEEKMWEQEEEMQEQEEKMRRQEEKIRE----QEKKIREQEEKIREQEEMMQEQEEK 468
Query: 179 SNMMHFGGYIQKQA--QTERKSGKRQTE--REKKKKILAERRKVLAIDHLNEDQLREKAK 234
G +++A Q + + +RQ E RE++KKI + K+ E+ ++E+ +
Sbjct: 469 MGEQE-GKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKI----REQEEMMQEQEE 523
Query: 235 ELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQ 272
++W+ E + + +EK ++Q+ ++ ++ + +
Sbjct: 524 KMWEQ----EEKMCEQEEKMQEQEEKMRRQEEKMREQE 557
Score = 67.0 bits (162), Expect = 2e-11
Identities = 49/229 (21%), Positives = 112/229 (48%), Gaps = 17/229 (7%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE--EEEEAKEAEDGPMEE 62
+E + E EE+ QEE + EQE+ E++A+ + E+ R +E++ E+EE + ++ M E
Sbjct: 356 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGE 415
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ K E + + +R E+ + E + I E +++EE +
Sbjct: 416 QEEK-----------MWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 464
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
++++ + + EQ+ E+E++ + +E RE+E+ R+ E++ R+++ +
Sbjct: 465 QEEKMGEQEGKMCEQEAKMQEQEEKMRR---QEEKIREQEKKIREQEEKIREQEEMMQEQ 521
Query: 183 HFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLRE 231
+ Q++ E++ K Q + EK ++ + R+ E++++E
Sbjct: 522 EEKMWEQEEKMCEQEE-KMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 61.2 bits (147), Expect = 1e-09
Identities = 57/259 (22%), Positives = 121/259 (46%), Gaps = 33/259 (12%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNL 74
+Q+E + QEE +E E E EE + E+EE ++ M E + K R
Sbjct: 284 QQQEEKMWRQEEKIQEREEKIQEQEE----KIREQEEKMRRQEEMMWEKEEKMRR----- 334
Query: 75 VPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAER 134
E + + + +E+ ++E + + E E +++EEE++ + R E+
Sbjct: 335 ------QEEMMWEKEEKIRELEEKMHEQEKIREQ--EEKRQEEEKIREQEKRQEQEAKMW 386
Query: 135 AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQT 194
++++IR + EK R+ +E +E+EE + E++ +++ + Q Q
Sbjct: 387 RQEEKIREQEEKIRE----QEEMMQEQEEKMGEQEEKMWEQEE-----------EMQEQE 431
Query: 195 ERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKF 254
E+ + + RE++KKI + K+ + + ++Q EK E + EA+ + +EK
Sbjct: 432 EKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ-EEKMGEQEGKMCEQEAKMQEQEEKM 490
Query: 255 KQQKYEINVLRNRINDNQK 273
++Q+ +I +I + ++
Sbjct: 491 RRQEEKIREQEKKIREQEE 509
Score = 54.7 bits (130), Expect = 9e-08
Identities = 40/168 (23%), Positives = 85/168 (50%), Gaps = 18/168 (10%)
Query: 1 MSDIEEVVEEYEEE--EQEEAAVEEQEEAAEEDAEAEAETEETRAEED--EEEEEAKEAE 56
M + EE + E EEE EQEE ++E+ E++ + + E+ R +E+ +E+EE +
Sbjct: 413 MGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQ 472
Query: 57 DGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKE 116
+G M E + K + E++ + + EK + E + I E +++
Sbjct: 473 EGKMCEQEAKMQE-----------QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ 521
Query: 117 EEELVSLKDRI---ERRRAERAEQQRIRNEREKERQNRLAEERARREE 161
EE++ ++++ E + E+ E+ R + E+ +E++ RL ++ + +E
Sbjct: 522 EEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 38.9 bits (89), Expect = 0.005
Identities = 62/308 (20%), Positives = 131/308 (42%), Gaps = 50/308 (16%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEA------------KEAED----- 57
E E+ A + +EA + EA+ +T + E + A EA D
Sbjct: 96 EDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 155
Query: 58 -------GPMEES-------KPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQ 103
G +E++ K K ++ L + + + + +++L E
Sbjct: 156 HDSWKFAGELEQALSAVATQKKKADRYIEELTKER----DALSLELYRNTITDEELKEKN 211
Query: 104 ALIEAHFENRKKEEEELVSLKDRIERRRAERAE----QQRIRNERE---KERQNRLAEER 156
A ++ + + E+ E + L + +R+ ERA+ QQ+++ E + KE Q+ A+ +
Sbjct: 212 AKLQEKLQLVESEKSE-IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQ 270
Query: 157 ARREEEE--NRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAE 214
A+ EE E NR + E + + + IQ+Q E K +++ + ++++++ E
Sbjct: 271 AQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQ---EEKIREQEEKMRRQEEMMWE 327
Query: 215 RRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKV 274
+ + + + EK +EL + ++ E EK QE+ +Q++ +I R K+
Sbjct: 328 KEEKMRRQEEMMWEKEEKIRELEEKMH--EQEKIREQEEKRQEEEKIREQEKRQEQEAKM 385
Query: 275 SKTRGKAK 282
+ K +
Sbjct: 386 WRQEEKIR 393
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 70.5 bits (171), Expect = 2e-12
Identities = 68/233 (29%), Positives = 119/233 (51%), Gaps = 39/233 (16%)
Query: 4 IEEVVEEYEEE-EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+E++ EE +++ EQ+ A ++E+ E A+E+ AE + ++ A + EE EA+ + EE
Sbjct: 588 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ----EE 643
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ R + E ++ +K+ E++ L+ EA ++E+E
Sbjct: 644 EARRLRWLQQ--------EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQ 695
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
+ ERR ER EQ+R RE+ERQ LAE+ RRE+E R +AE E +++
Sbjct: 696 ERREQERREQERREQER----REQERQ--LAEQERRREQE--RLQAERELQER------- 740
Query: 183 HFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 235
+K + +++ +R+ E +KKK E ++ LA L E+Q +KAKE
Sbjct: 741 ------EKALRLQKEQLQRELEEKKKK----EEQQRLAERQLQEEQ-EKKAKE 782
Score = 60.8 bits (146), Expect = 1e-09
Identities = 57/254 (22%), Positives = 118/254 (46%), Gaps = 16/254 (6%)
Query: 37 ETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRME 96
E E R E +EEA++ +EE K + L K+ ER+ R+R+E
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRR------RLEEVKLKREERLRKVLQARERVE 589
Query: 97 KDLNELQALIEAHF----ENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQN-- 150
+ E + IE F E +K +EE ++ + ++ A++ E+ R ++E+E +
Sbjct: 590 QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 649
Query: 151 --RLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKK 208
+ EE R +E ++K E++ R +KA Q++ + ER+ +R+ + ++
Sbjct: 650 WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE 709
Query: 209 KKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRI 268
++ + R++ + E + + +EL + L +K LQ + +++K + + R+
Sbjct: 710 QERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEE--QQRL 767
Query: 269 NDNQKVSKTRGKAK 282
+ Q + KAK
Sbjct: 768 AERQLQEEQEKKAK 781
Score = 57.4 bits (137), Expect = 1e-08
Identities = 45/176 (25%), Positives = 87/176 (49%), Gaps = 20/176 (11%)
Query: 8 VEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKP 67
+EE E ++E +E+ E + + +E+E+E K AE + E + +
Sbjct: 632 MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE 691
Query: 68 RSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRI 127
R + ER + + ++R E++ E + + + R++E+E L + ++
Sbjct: 692 RR-----------EQERREQERREQERREQERREQERQLAE--QERRREQERLQAERELQ 738
Query: 128 ERRRAERAEQQRIRNERE----KERQNRLAEERARREEEENRRKAEDEARKKKALS 179
ER +A R ++++++ E E KE Q RLAE R+ +EE +KA++ A KAL+
Sbjct: 739 EREKALRLQKEQLQRELEEKKKKEEQQRLAE---RQLQEEQEKKAKEAAGASKALN 791
Score = 54.3 bits (129), Expect = 1e-07
Identities = 47/200 (23%), Positives = 94/200 (47%), Gaps = 13/200 (6%)
Query: 67 PRSFMPNLVPPKIP--DGERVDFDDIHRKRME--KDLNELQALIEAHFENRKKEEEELVS 122
PRS M + + P + F + R+R+E + E + L E K+ E V
Sbjct: 512 PRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVK 571
Query: 123 LK--DRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
LK +R+ + R ++++ E++K+ + + A+ + E+ + R AE++A+KK A
Sbjct: 572 LKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKK 631
Query: 181 MMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI 240
M +++ + R +Q E E++ + L +++K E + KA E +
Sbjct: 632 MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKE------EEQERLRKAAEAKRLA 685
Query: 241 YNLEAEKFDLQEKFKQQKYE 260
E E+ + QE+ +Q++ E
Sbjct: 686 EQREQERRE-QERREQERRE 704
Score = 29.6 bits (65), Expect = 3.2
Identities = 20/81 (24%), Positives = 42/81 (51%), Gaps = 5/81 (6%)
Query: 13 EEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSF-- 70
++EQ + +EE+++ E+ AE + +E + ++ +E A +A + ++ P S+
Sbjct: 747 QKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQM 806
Query: 71 --MPNLVPPKI-PDGERVDFD 88
+ PPKI PD +D +
Sbjct: 807 TPQGHRAPPKINPDNYGMDLN 827
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 70.5 bits (171), Expect = 2e-12
Identities = 68/233 (29%), Positives = 119/233 (51%), Gaps = 39/233 (16%)
Query: 4 IEEVVEEYEEE-EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+E++ EE +++ EQ+ A ++E+ E A+E+ AE + ++ A + EE EA+ + EE
Sbjct: 584 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ----EE 639
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ R + E ++ +K+ E++ L+ EA ++E+E
Sbjct: 640 EARRLRWLQQ--------EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQ 691
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
+ ERR ER EQ+R RE+ERQ LAE+ RRE+E R +AE E +++
Sbjct: 692 ERREQERREQERREQER----REQERQ--LAEQERRREQE--RLQAERELQER------- 736
Query: 183 HFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 235
+K + +++ +R+ E +KKK E ++ LA L E+Q +KAKE
Sbjct: 737 ------EKALRLQKEQLQRELEEKKKK----EEQQRLAERQLQEEQ-EKKAKE 778
Score = 60.8 bits (146), Expect = 1e-09
Identities = 57/254 (22%), Positives = 118/254 (46%), Gaps = 16/254 (6%)
Query: 37 ETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRME 96
E E R E +EEA++ +EE K + L K+ ER+ R+R+E
Sbjct: 532 EKERQRLENLRRKEEAEQLRRQKVEEDKRR------RLEEVKLKREERLRKVLQARERVE 585
Query: 97 KDLNELQALIEAHF----ENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQN-- 150
+ E + IE F E +K +EE ++ + ++ A++ E+ R ++E+E +
Sbjct: 586 QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
Query: 151 --RLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKK 208
+ EE R +E ++K E++ R +KA Q++ + ER+ +R+ + ++
Sbjct: 646 WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE 705
Query: 209 KKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRI 268
++ + R++ + E + + +EL + L +K LQ + +++K + + R+
Sbjct: 706 QERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEE--QQRL 763
Query: 269 NDNQKVSKTRGKAK 282
+ Q + KAK
Sbjct: 764 AERQLQEEQEKKAK 777
Score = 57.4 bits (137), Expect = 1e-08
Identities = 45/176 (25%), Positives = 87/176 (49%), Gaps = 20/176 (11%)
Query: 8 VEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKP 67
+EE E ++E +E+ E + + +E+E+E K AE + E + +
Sbjct: 628 MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE 687
Query: 68 RSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRI 127
R + ER + + ++R E++ E + + + R++E+E L + ++
Sbjct: 688 RR-----------EQERREQERREQERREQERREQERQLAE--QERRREQERLQAERELQ 734
Query: 128 ERRRAERAEQQRIRNERE----KERQNRLAEERARREEEENRRKAEDEARKKKALS 179
ER +A R ++++++ E E KE Q RLAE R+ +EE +KA++ A KAL+
Sbjct: 735 EREKALRLQKEQLQRELEEKKKKEEQQRLAE---RQLQEEQEKKAKEAAGASKALN 787
Score = 56.2 bits (134), Expect = 3e-08
Identities = 48/198 (24%), Positives = 95/198 (47%), Gaps = 13/198 (6%)
Query: 67 PRSFMPNLVPPKIPDGERVDFDDIHRKRME--KDLNELQALIEAHFENRKKEEEELVSLK 124
PRS M + + P R+D + R+R+E + E + L E K+ E V LK
Sbjct: 512 PRSVMKSFIKRNTP--LRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK 569
Query: 125 --DRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
+R+ + R ++++ E++K+ + + A+ + E+ + R AE++A+KK A M
Sbjct: 570 REERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKME 629
Query: 183 HFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYN 242
+++ + R +Q E E++ + L +++K E + KA E +
Sbjct: 630 EVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKE------EEQERLRKAAEAKRLAEQ 683
Query: 243 LEAEKFDLQEKFKQQKYE 260
E E+ + QE+ +Q++ E
Sbjct: 684 REQERRE-QERREQERRE 700
Score = 29.6 bits (65), Expect = 3.2
Identities = 20/81 (24%), Positives = 42/81 (51%), Gaps = 5/81 (6%)
Query: 13 EEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSF-- 70
++EQ + +EE+++ E+ AE + +E + ++ +E A +A + ++ P S+
Sbjct: 743 QKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQM 802
Query: 71 --MPNLVPPKI-PDGERVDFD 88
+ PPKI PD +D +
Sbjct: 803 TPQGHRAPPKINPDNYGMDLN 823
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 69.7 bits (169), Expect = 3e-12
Identities = 60/261 (22%), Positives = 118/261 (45%), Gaps = 35/261 (13%)
Query: 23 EQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDG 82
++E E + E E E R +E+++ K+ E G E K K R +
Sbjct: 37 KKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKER------------EK 84
Query: 83 ERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRN 142
+R + + R++ +K+ + + E +KK+E + ++R ++R ER ++R +
Sbjct: 85 QRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKE---RERENKQRRERKRKKRRKK 141
Query: 143 EREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQ 202
+R KER+ E+ R + E R+K + E R+KK N +K+ + ++ +R+
Sbjct: 142 KRRKERKR----EKERGKRERKRKKRKKEEREKKRERNRKE-----RKKERERKERRERK 192
Query: 203 TEREKKKKILAERRKVLAIDHLNEDQ----LREKAKE-------LWQSIYNLEAEKFDLQ 251
ER+K+++ ER+K D + Q LRE A I++ + F ++
Sbjct: 193 KERKKERRKKKERKKDRKTDRQTDSQVFRPLRESAFNRVTVTGVFRYRIFHTGLDHFPIK 252
Query: 252 EKFKQQKYEINVLRNRINDNQ 272
++E+N +ND +
Sbjct: 253 TNILLSRHEVNDGEIEVNDGE 273
Score = 55.8 bits (133), Expect = 4e-08
Identities = 46/200 (23%), Positives = 90/200 (45%), Gaps = 23/200 (11%)
Query: 101 ELQALIEAHFEN--RKKEEEELVSLKDRIERRRAERAEQQRIR----------------- 141
ELQ + +H ++E E ++R +R+R E++R R
Sbjct: 16 ELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKER 75
Query: 142 ----NEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERK 197
EREK+R+ R +ER +R++E+ +R+ + R+++ KQ + ++
Sbjct: 76 ERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKR 135
Query: 198 SGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQ 257
+R+ +R K++K ER K + + REK +E + E E+ + +E+ K++
Sbjct: 136 KKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKER 195
Query: 258 KYEINVLRNRINDNQKVSKT 277
K E + R D + +T
Sbjct: 196 KKERRKKKERKKDRKTDRQT 215
Score = 47.8 bits (112), Expect = 1e-05
Identities = 29/158 (18%), Positives = 74/158 (46%), Gaps = 11/158 (6%)
Query: 9 EEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPR 68
+E ++ ++ E E + + E + + + E+ R + +E+++ + + G E K K R
Sbjct: 61 KEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKER 120
Query: 69 SFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIE 128
+ ER + RKR ++ + + + E K+E + K+ E
Sbjct: 121 K-----------ERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEERE 169
Query: 129 RRRAERAEQQRIRNEREKERQNRLAEERARREEEENRR 166
++R ++++ ER++ R+ + ++ RR+++E ++
Sbjct: 170 KKRERNRKERKKERERKERRERKKERKKERRKKKERKK 207
Score = 42.0 bits (97), Expect = 6e-04
Identities = 38/147 (25%), Positives = 71/147 (48%), Gaps = 10/147 (6%)
Query: 142 NEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKR 201
+ER+KER+ R E+R R E+E +R+ + +KK+ +K+ + +RK +R
Sbjct: 34 SERKKERRER--EKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKE-RR 90
Query: 202 QTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEI 261
+ ER K+KK +R + + RE+ K+ + E ++ +++ K++K +
Sbjct: 91 EKERRKRKKEKKKRER-------KQRGRRERKKKKERKERERENKQRRERKRKKRRKKKR 143
Query: 262 NVLRNRINDNQKVSKTRGKAKVTGRWK 288
R R + K + R K K R K
Sbjct: 144 RKERKREKERGKRERKRKKRKKEEREK 170
Score = 37.7 bits (86), Expect = 0.012
Identities = 33/147 (22%), Positives = 69/147 (46%), Gaps = 8/147 (5%)
Query: 139 RIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKS 198
++ E + + +++ +RE E + + E E RK++ G +K+ + +R+
Sbjct: 12 KLNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRER 71
Query: 199 GK-RQTEREKKKKILAERRKVLAIDHLNEDQLREK----AKELWQSIYNLEAEKFDLQEK 253
GK R+ +R++++K ERR+ E + RE+ +E + E E+ + Q +
Sbjct: 72 GKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRR 131
Query: 254 FKQQKYEINVLRNRINDNQKVSKTRGK 280
+++K R + +K K RGK
Sbjct: 132 ERKRKKRRKKKRRK---ERKREKERGK 155
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 69.7 bits (169), Expect = 3e-12
Identities = 68/275 (24%), Positives = 126/275 (45%), Gaps = 22/275 (8%)
Query: 8 VEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKP 67
V+ +E QE+ +EQEE AE ++ +++ + EE E + + S +
Sbjct: 10 VKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRR 69
Query: 68 RSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRI 127
M +R + DD + + ++ + + E RK+++ V K+R
Sbjct: 70 EDSME----------DRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKERE 119
Query: 128 -ERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGG 186
ERR+ R EQ + R E E++++ +A E +RRE R + E RK++ M
Sbjct: 120 HERRKRHREEQDKARREWERQKRREMAREHSRRE----RDRLEQLERKRERERKMREQQK 175
Query: 187 YIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQL-REKAKELWQSIYNLEA 245
++Q + ER++ +R+ ERE ++++ A R + ED + KA +S
Sbjct: 176 EQREQKERERRAEERRKEREARREVSAHHRT------MREDYSDKVKASHWSRSPPRPPR 229
Query: 246 EKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGK 280
E+F+L + K K E R+ ++D Q +S + K
Sbjct: 230 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERK 264
Score = 50.1 bits (118), Expect = 2e-06
Identities = 50/214 (23%), Positives = 85/214 (39%), Gaps = 23/214 (10%)
Query: 8 VEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKP 67
+E+ E + + E + EQ++ E E E EE R E E E E+ K
Sbjct: 157 LEQLERKRERERKMREQQKEQREQKERERRAEERRKER-EARREVSAHHRTMREDYSDKV 215
Query: 68 RSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS-LKDR 126
++ + PP+ P ER + D RK ++++ K EE +L+S L+D
Sbjct: 216 KASHWSRSPPR-PPRERFELGD-GRKPVKEE---------------KMEERDLLSDLQDI 258
Query: 127 IERRR----AERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
+ R AE + + E+E + EE EE + E+E +++ SN
Sbjct: 259 SDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSE 318
Query: 183 HFGGYIQKQAQTERKSGKRQTEREKKKKILAERR 216
++ E S + E E ++ E R
Sbjct: 319 EASEQSAEEVSEEEMSEDEERENENHLLVVPESR 352
Score = 50.1 bits (118), Expect = 2e-06
Identities = 33/119 (27%), Positives = 49/119 (41%), Gaps = 14/119 (11%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
+SD E E E + E+EE EE+ E E T E EE+EEEEE +E
Sbjct: 258 ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS 317
Query: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEE 119
EE+ + E V +++ ++ N L + E+ F+ E EE
Sbjct: 318 EEASEQ--------------SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEE 362
Score = 38.9 bits (89), Expect = 0.005
Identities = 45/161 (27%), Positives = 67/161 (41%), Gaps = 22/161 (13%)
Query: 2 SDIEEVVEEYEEEE--------QEEAAVEEQEEAAEEDAEAEAETE-----ETRAEEDEE 48
S+ EE EE EEEE E++A E EE ED E E E E+R + D
Sbjct: 299 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 358
Query: 49 EEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEA 108
E E E E G E P+ + P P ++ ++ + K L LQ
Sbjct: 359 ESEEAEEEVG---EGTPQSSALTEGDYVPDSPALSPIEL----KQELPKYLPALQGCRSV 411
Query: 109 -HFENRKKEEEELVSLKDRI-ERRRAERAEQQRIRNEREKE 147
F+ + EE + R +++ E +R++ E+EKE
Sbjct: 412 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKE 452
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 69.3 bits (168), Expect = 4e-12
Identities = 59/301 (19%), Positives = 137/301 (45%), Gaps = 26/301 (8%)
Query: 5 EEVVEEYEEE--EQEEAAVEEQEEAAEEDAEAEAETEETRAEED---EEEEEAKEAEDGP 59
EE + E E++ +QEE ++E E++ + + E+ R +E E+E+E +E E
Sbjct: 240 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKEL 299
Query: 60 MEESKPKPRSFMPNLVPPKI-PDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEE 118
E+ K + + K+ E++ + R E+ L E + + + + +EE
Sbjct: 300 REQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 359
Query: 119 ELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKAL 178
+ +R+ + EQ+++ + EK ++ ER ++ EE E E + +K
Sbjct: 360 RMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE 419
Query: 179 SNMMHFGGYIQKQAQTER------KSGKRQTEREKKKKILAERRKVLAIDHL-------- 224
NM +K+ Q +R K +++ +E+++KI + K+ + +
Sbjct: 420 ENMWE---QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMW 476
Query: 225 NEDQLREKAKELW---QSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKA 281
++++RE+ ++W + + + E + +D +E+ +Q + R+ + +K+ + K
Sbjct: 477 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKM 536
Query: 282 K 282
+
Sbjct: 537 R 537
Score = 66.2 bits (160), Expect = 3e-11
Identities = 60/296 (20%), Positives = 136/296 (45%), Gaps = 25/296 (8%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEE---EEAKEAED 57
M + EE ++E E + E + E+EE E E + EE E++E+E + E ++
Sbjct: 381 MWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKE 440
Query: 58 GPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKE- 116
E+ K + + KI D E + + R EK + + E + R +E
Sbjct: 441 KLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ 500
Query: 117 -----EEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARR--------EEEE 163
EE + +R+ + EQ+++ + EK R+ + +E+ ++ EEE
Sbjct: 501 KMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEE 560
Query: 164 NRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAER---RKVLA 220
R+ E + R+++ + M +Q+Q + R+ ++ E+E+K + E+ ++
Sbjct: 561 RMREREKKMREEEEM--MREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKM 618
Query: 221 IDHLNEDQLREKAKELW---QSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQK 273
+ ED+++E+ + +W + + E + ++ +EK ++Q+ ++ ++ ++
Sbjct: 619 WEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEE 674
Score = 63.2 bits (152), Expect = 3e-10
Identities = 58/277 (20%), Positives = 135/277 (48%), Gaps = 30/277 (10%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEED---EEEEEAKEAED 57
M + +E + E EE +E+ + EQEE +E+ ++ R EE+ E+EE+ ++ E+
Sbjct: 361 MWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEE 420
Query: 58 GPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALI---EAHFENRK 114
E+ + + + ++P+ + ++ + E+ + E + I E + K
Sbjct: 421 NMWEQEEKEWQQ-------QRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEK 473
Query: 115 K--EEEELVSLKDRI-ERRRAERAEQQRIRNEREK--ERQNRLAEERARREEEENRRKAE 169
K +E++ +D++ E+ R ++Q++ ++ E+ E+ RL E+ R E++ + E
Sbjct: 474 KMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQE 533
Query: 170 DEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHL---NE 226
++ R++K +K E K + + RE++KK+ E + + E
Sbjct: 534 EKMREEKKTQEQE------KKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQE 587
Query: 227 DQLREKAKELW---QSIYNLEAEKFDLQEKFKQQKYE 260
+++RE+ +++W + + E + ++ +EK +Q+ E
Sbjct: 588 EKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEE 624
Score = 61.2 bits (147), Expect = 1e-09
Identities = 53/272 (19%), Positives = 134/272 (49%), Gaps = 26/272 (9%)
Query: 24 QEEAAEEDAEAEAETEETRAEEDE--EEEEAKEAEDGPMEESKPKPRSFMPNL--VPPKI 79
QEE ++ E + ++ R +E++ +EE ++G M E + K R L ++
Sbjct: 233 QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKEL 292
Query: 80 PDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRI-ERRRAERAEQQ 138
+ E+ + + E+ + E + + E +++EE++ ++R+ E+ + R ++Q
Sbjct: 293 REQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 352
Query: 139 RIRNEREK--ERQNRLAEERARREEE----ENRRKAEDEARKKKALSNMMHFGGYIQKQA 192
++R++ E+ E+ RL E+ R E+ E K ++E R ++ M +++Q
Sbjct: 353 KMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQE 412
Query: 193 QTERKSGKRQTEREKK---KKILAERRKVLAIDHLNEDQLREKAKELWQSIYNL------ 243
+ +K + E+E+K ++ L E+++ L +++++E+ +++W+ +
Sbjct: 413 EKMQKQEENMWEQEEKEWQQQRLPEQKEKL----WEQEKMQEQEEKIWEQEEKIRDQEEM 468
Query: 244 --EAEKFDLQEKFKQQKYEINVLRNRINDNQK 273
+ +K QEK ++Q+ ++ ++ D ++
Sbjct: 469 WGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ 500
Score = 60.8 bits (146), Expect = 1e-09
Identities = 56/273 (20%), Positives = 129/273 (47%), Gaps = 27/273 (9%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE--EEEEAKEAEDGPMEE 62
++ + E +E+ E+ ++EQEE E E + EE +E + +E+ +E ED M E
Sbjct: 432 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED-QMWE 490
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALI--EAHFENRKKEEEEL 120
+ K R + + ER+ D + E+ + E + + E KK +E+
Sbjct: 491 QEEKMRDQEQKMWDQE----ERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQE 546
Query: 121 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
D+ E+ R E ++R + RE+E R EE+ + +EE+ R + E +++ +
Sbjct: 547 KKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKM-- 604
Query: 181 MMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI 240
Q+Q + + ++ E+E++ K+ + + E++++E+ +++W+
Sbjct: 605 --------QEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWE----QEEKMQEQEEKMWEQ- 651
Query: 241 YNLEAEKFDLQEKFKQQKYEINVLRNRINDNQK 273
E + + +EK ++Q+ ++ ++ + ++
Sbjct: 652 ---EEKMREQEEKMREQEEKMQGQEEKMREQEE 681
Score = 56.6 bits (135), Expect = 2e-08
Identities = 51/218 (23%), Positives = 103/218 (47%), Gaps = 19/218 (8%)
Query: 10 EYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE--EEEEAKEAEDGPMEESKPKP 67
+ EE+ +EE +EQE+ + E E E R E + EEEE ++ M+E + K
Sbjct: 531 QQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 590
Query: 68 RSFMPNL--VPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKK--EEEELVSL 123
R + K+ + E ++ + +++ +++Q E +E +K E+EE
Sbjct: 591 REQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEE---- 646
Query: 124 KDRIERRRAERAEQQRIRNEREKERQNRL-AEERARREEEENRRKAEDEAR--KKKALSN 180
+ E+ E+ R + E+ +E++ ++ +E RE+EE + E++ R ++K
Sbjct: 647 ------KMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQ 700
Query: 181 MMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKV 218
G +K E K ++ REK+++I ++ K+
Sbjct: 701 EEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKM 738
Score = 54.7 bits (130), Expect = 9e-08
Identities = 55/260 (21%), Positives = 120/260 (46%), Gaps = 30/260 (11%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
M + +E + E EE +E+ + +QEE E+ + + + ++T +E++ EE + E
Sbjct: 509 MWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRE---- 564
Query: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKK--EEE 118
E K + M K+ + E + ++M + ++Q E +E +K E+E
Sbjct: 565 REKKMREEEEMMREQEEKMQEQEEKMREQ--EEKMWEQEEKMQEQEEKMWEQEEKMWEQE 622
Query: 119 ELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKAL 178
E +D+++ + EQ+ E+E++ +E RE+EE R+ E++ +
Sbjct: 623 E----EDKMQEQEEMMWEQEEKMQEQEEKMWE---QEEKMREQEEKMREQEEKMQ----- 670
Query: 179 SNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQ 238
G + + Q E+ G+ + RE+++K+ + K+ E+++ + +++W
Sbjct: 671 ------GQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWG----QEEKMWGQEEKMWG 720
Query: 239 SIYNLEAEKFDLQEKFKQQK 258
E E+ +K K Q+
Sbjct: 721 QEEMREKEERIRDQKEKMQE 740
Score = 53.5 bits (127), Expect = 2e-07
Identities = 48/212 (22%), Positives = 97/212 (45%), Gaps = 27/212 (12%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE---EEEEAKEAED 57
M + E + E ++ +EE + EQEE +E E E EE E++E E+EE ++
Sbjct: 556 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQE 615
Query: 58 GPM----EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKR-MEKDLNELQALIEAHFEN 112
M EE K + + M K+ + E ++ + R E+ + E + ++ E
Sbjct: 616 EKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEK 675
Query: 113 RKKEEEELVSLKDRI-ERRRAERAEQQRIRNEREK---------------ERQNRLAEER 156
+++EE++ ++++ E+ R +++++ + EK E++ R+ +++
Sbjct: 676 MREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQK 735
Query: 157 ARREE---EENRRKAEDEARKKKALSNMMHFG 185
+ +E E R +E K L NM H G
Sbjct: 736 EKMQERLPEHEERCSEPCLPPSKVLCNMSHTG 767
Score = 50.8 bits (120), Expect = 1e-06
Identities = 48/253 (18%), Positives = 115/253 (45%), Gaps = 22/253 (8%)
Query: 25 EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGER 84
EE +++AE + + +E+ E + KE ++ + + +P + + +
Sbjct: 183 EELKKKNAELQEKLRLAESEKSEIQLNVKE-----LKRKLERAKFLLPQVQTNTLQE--- 234
Query: 85 VDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNER 144
R E++L E + I E ++EE L + ++ + + Q++ E+
Sbjct: 235 ------EMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQ 288
Query: 145 EK---ERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKR 201
EK E++ L E++ RE+EE ++ E++ +++ + Q++ E++ R
Sbjct: 289 EKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 348
Query: 202 QTEREKKKKILAERRKVLAIDHLNEDQLREKAKE-LWQSIYNLEAEKFDLQEKFKQQKYE 260
+ E++ + + E R + L E + R + +E +W+ ++ E+ ++E+ K+ + E
Sbjct: 349 EQEQKMRDQ---EERMWEQDERLREKEERMREQEKMWEQEEKMQEEE-RIREREKKMREE 404
Query: 261 INVLRNRINDNQK 273
+R + QK
Sbjct: 405 EETMREQEEKMQK 417
Score = 48.9 bits (115), Expect = 5e-06
Identities = 60/301 (19%), Positives = 130/301 (43%), Gaps = 53/301 (17%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAET------EETRAEED--EEEEEAKEAEDGPMEESKP- 65
E E+ A + +EA + EA+ T ++T E ++ A++ EDG + ESK
Sbjct: 70 EDEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESKDL 129
Query: 66 --------------------------KPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDL 99
K ++ L + + + I + ++K
Sbjct: 130 AGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKN 189
Query: 100 NELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARR 159
ELQ + + + + + LK ++ER + + Q + E RQ EE R
Sbjct: 190 AELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ----EEELRE 245
Query: 160 EEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREK----KKKILAER 215
+E++ R++ E R+++ L G +++Q + R+ KR E+EK ++K L E+
Sbjct: 246 QEKKIRKQEEKMWRQEERLREQ---EGKMREQEEKMRRQEKRLREQEKELREQEKELREQ 302
Query: 216 RKVLAIDHLNEDQLREKAKELW---QSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQ 272
+K+ E+Q++E+ +++W + + E + + +E+ +Q+ ++ ++ D +
Sbjct: 303 KKL----REQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQE 358
Query: 273 K 273
+
Sbjct: 359 E 359
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 68.2 bits (165), Expect = 8e-12
Identities = 78/309 (25%), Positives = 142/309 (45%), Gaps = 47/309 (15%)
Query: 1 MSDIEEVVEEYEEEEQE-----EAAVEEQEEAAEEDAEAEAETE-ETRAEEDEEEEEAKE 54
M + E + E+ EE+E EAA+E+Q + AE A+A+A+ E E + + +EE
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 55 AEDGPMEESKPKPRSFMPNLVPPKIPD-------GERVDFDDIHRKRMEKDLNELQALIE 107
E+ ++ + K RS L + + + + R R+E+++ ++ +E
Sbjct: 1404 REEAAVDAQQQK-RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 108 AHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEE---- 163
A R E EL +L R RAE AE Q+ + + E ER R ++ ++R+ +
Sbjct: 1463 ATERQRGGAEGELQAL-----RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 164 -NRRKAEDEA--RKKKALSNMMHFGGYIQ------KQAQTER--------KSGKRQTERE 206
+R KAE EA K++AL + + +QA+ ER ++ +R E E
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1577
Query: 207 KKKK------ILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYE 260
+ K A+ + L +H+ QLRE+A+ Q E + + + + ++ + +
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637
Query: 261 IN-VLRNRI 268
N LR R+
Sbjct: 1638 ANEALRLRL 1646
Score = 53.5 bits (127), Expect = 2e-07
Identities = 67/303 (22%), Positives = 129/303 (42%), Gaps = 29/303 (9%)
Query: 12 EEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFM 71
E+ Q +A +EE+ + +++E E ++ E+ + E E ++ S K +
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 72 PNLVPPKIPDGE-RVDFDDIHRKRMEKDLNEL-QALIEAHFENRKKEEEELV--SLKDRI 127
L ++ G R + +D R + + +L Q + A E R++E EE V SL
Sbjct: 1942 AEL---ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998
Query: 128 ERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGY 187
E R +A + + + K + R ERA +E + A++ A+K+ H
Sbjct: 1999 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2058
Query: 188 IQK----------------QAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNE-DQLR 230
QK Q + E ++ +R E ++ ++ AER + + E ++L+
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 231 EKAKELWQSIYNLEAEKFDL-----QEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTG 285
+ A+E Q+ +A L QE ++ + E LR + + ++ K + A+ T
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 286 RWK 288
R K
Sbjct: 2179 RQK 2181
Score = 53.5 bits (127), Expect = 2e-07
Identities = 66/277 (23%), Positives = 123/277 (44%), Gaps = 45/277 (16%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
+ + E + + EE+ Q A + E ++AE EA RA+ ++ K+A D M
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQAALRQKQAADAEM 2167
Query: 61 EESKPKPRSFMPNLVPPKIPDGE-------RVDFDDIHRKRMEKDLNELQALIEAHFENR 113
E K + F + K + +++ D + ++++L L+A R
Sbjct: 2168 E----KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Query: 114 KKEEEELVS----------LKDRIERRR-----AERAEQQRIRNEREKERQNRLAEERAR 158
+ EEEL S LK RIE ++ QR E E E+ ++AEE AR
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAAR 2282
Query: 159 -----REEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTERE---KKKK 210
+E R+ AE++ +++AL+ M ++++ Q +++ + + E E ++K+
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKM-----LKEKMQAVQEATRLKAEAELLQQQKE 2337
Query: 211 ILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEK 247
+ E+ + L D E ++ A+E LEAE+
Sbjct: 2338 LAQEQARRLQED--KEQMAQQLAEETQGFQRTLEAER 2372
Score = 52.8 bits (125), Expect = 4e-07
Identities = 63/264 (23%), Positives = 113/264 (42%), Gaps = 39/264 (14%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE E EE+ + ++ +EEAA + A E E +A+ +E + AE + +
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ L + H +++ ELQ ++ +E+ L L+
Sbjct: 2038 LAQEAAQKRLQAE----------EKAHAFAVQQKEQELQQTLQ-------QEQSVLDQLR 2080
Query: 125 DRIE--RRRAERAEQQRIRNEREKERQNRLAEERARRE---EEENRRKAEDEARKKKALS 179
E RR AE AE+ R++ ERE + R EE R + EE+ + +A+ +A +K
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK--- 2137
Query: 180 NMMHFGGYIQKQAQTE--RKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAK-EL 236
++K+A+ E R++ Q +K+ AE K E LR+KA+ E
Sbjct: 2138 --------LRKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQ 2186
Query: 237 WQSIYNLEAEKFDLQEKFKQQKYE 260
+ L+ E+ D Q+ ++ +
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQ 2210
Score = 51.6 bits (122), Expect = 8e-07
Identities = 68/313 (21%), Positives = 131/313 (41%), Gaps = 50/313 (15%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETE------------------------- 39
EE V + E+ E ++Q EA EAE E E
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1657
Query: 40 -ETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKD 98
+ AE+ +EE E + G EE + R + + + + R E++
Sbjct: 1658 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQQRLAAEQE 1714
Query: 99 LNELQALIEAHFENRKKEEEELVSLKDR----IERRRAERAEQQRIRNEREKERQNRL-A 153
L L+A E + R+ EEEL L+ ++R+ AE ++R E E ++ A
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774
Query: 154 EERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREK--KKKI 211
EE +R E+++++ E EA + + L+ + ++A+ +R+ + R++ +++
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 212 LAERRKVLAIDHLN------EDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLR 265
LAE K+ AI E L+EK E N + E F++++ E +
Sbjct: 1835 LAE--KLAAIGEATRLKTEAEIALKEKEAE------NERLRRLAEDEAFQRRRLEEQAAQ 1886
Query: 266 NRINDNQKVSKTR 278
++ + +++++ R
Sbjct: 1887 HKADIEERLAQLR 1899
Score = 49.3 bits (116), Expect = 4e-06
Identities = 60/243 (24%), Positives = 106/243 (43%), Gaps = 58/243 (23%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNL 74
++E AV + E AE A+ +AE E R E + E E +
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ--------------------- 1635
Query: 75 VPPKIPDGERVDFDDIHRKRME-KDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAE 133
+ ++ R R++ +++ + ++L +A E +K+E E E RR
Sbjct: 1636 ----------LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER--------EARRRG 1677
Query: 134 RAEQQRIRN----EREKERQNRLAE----ERARREEEENRRKAEDE--ARKKKALSNMMH 183
+AE+Q +R E+E E+Q +LAE +R E+E R +AE E ++++ L +
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL- 1736
Query: 184 FGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNL 243
+ Q + + KRQ + K+ AE +LA E++ R ++ +S L
Sbjct: 1737 ----ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE---KSKQRL 1789
Query: 244 EAE 246
EAE
Sbjct: 1790 EAE 1792
Score = 48.5 bits (114), Expect = 7e-06
Identities = 72/294 (24%), Positives = 126/294 (42%), Gaps = 45/294 (15%)
Query: 2 SDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEE--------EEAK 53
+++ +V E E +A EE+ + E ++ E E R E EE EEAK
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 54 EAEDGPMEESKPKPRSFMPNLVPPK---IPDGERVDFD-DIHRKRMEKDLNELQALIEAH 109
EE + R+ ++ K I + R+ + +I K E + L+ L E
Sbjct: 1815 RQRQ-LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1873
Query: 110 FENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAE 169
R++ EE+ K IE ER Q R ++ E ERQ L E+ R+ RR+ E
Sbjct: 1874 AFQRRRLEEQAAQHKADIE----ERLAQLRKASDSELERQKGLVEDTLRQ-----RRQVE 1924
Query: 170 DEARKKKALSNMMHFG--------GYIQKQAQ-TERKSGKRQTEREKKKKILAERRKVLA 220
+E KA G G I+ A+ T R + + E +++++ AE
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE------ 1978
Query: 221 IDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKV 274
E++ R +A+E Q +L AE+ +++ K E+ L+ ++ + +++
Sbjct: 1979 -----EERRRREAEERVQK--SLAAEEEAARQR-KAALEEVERLKAKVEEARRL 2024
Score = 46.2 bits (108), Expect = 3e-05
Identities = 57/251 (22%), Positives = 109/251 (43%), Gaps = 28/251 (11%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQ--------EEAAEEDAEAEAETEETRAEEDEEEEEAKEA 55
+++ +E ++ Q+E +V +Q AAEE EA + E A+ + EEA+
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117
Query: 56 EDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKK 115
+ E+++ + ++ K+ + + + R + E+ + +A E KK
Sbjct: 2118 KQSAEEQAQARAQA---QAAAEKL--RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 116 EEEELVSLKDRIE------RRRAERAEQQRIRNEREKERQNRLAEERARR-----EEEEN 164
E+ + K ++E R + E + Q+ + E +R A E AR+ EE +
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 165 RRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHL 224
R +E K KA + ++ + T+R Q E EK K++ AE L++
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQR---FLQEEAEKMKQV-AEEAARLSVAAQ 2288
Query: 225 NEDQLREKAKE 235
+LR+ A+E
Sbjct: 2289 EAARLRQLAEE 2299
Score = 44.3 bits (103), Expect = 1e-04
Identities = 53/224 (23%), Positives = 98/224 (43%), Gaps = 31/224 (13%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+I E + E QE+ + + E + ++ +AE E E E+E + E
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE------ 2465
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKR---MEKDLNELQALI--EAHFENRKKEE 117
L+ K + + V + + ++ + L+E +L+ E E K +
Sbjct: 2466 ---------AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 118 EELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE-ERARREEEENRRKAEDEARKKK 176
E+L +D + + + R EQQR + + E+ERQ +A E ARR + E AE+ R+K+
Sbjct: 2517 EQL--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQ 2570
Query: 177 ALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLA 220
+ Q++ Q E + + Q RE+ + + + R LA
Sbjct: 2571 EELQQLE----QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2610
Score = 41.6 bits (96), Expect = 8e-04
Identities = 58/302 (19%), Positives = 130/302 (43%), Gaps = 37/302 (12%)
Query: 6 EVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKP 65
+ V+E + E +++Q+E A+E A E +E A++ EE + + +E +
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR---TLEAERQ 2373
Query: 66 KPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEE---EELVS 122
+ K+ RV + R E+D + E E + E +E V+
Sbjct: 2374 RQLEMSAEAERLKL----RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2429
Query: 123 LKDRIERRR------AERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKK 176
L +E +R AER + EREKE+ + A+ + EE + E ++ +
Sbjct: 2430 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489
Query: 177 AL--SNMMHFGGYIQKQAQTERKSGK---------------RQTEREKKKKILAERRKVL 219
AL S + +Q++ E++ K R+ ++ +++++ ER++++
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 220 AIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRG 279
A + ++ R + E + + + E L+++ +QQ+ + R+ + ++ + +
Sbjct: 2550 A----SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605
Query: 280 KA 281
+A
Sbjct: 2606 RA 2607
Score = 41.6 bits (96), Expect = 8e-04
Identities = 47/233 (20%), Positives = 100/233 (42%), Gaps = 32/233 (13%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE + + ++ +E + E A ++ +T E + ++ + + E +E K
Sbjct: 2400 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRM---EKDLNELQALI--EAHFENRKKEEEE 119
K + L+ K + + V + + ++ + L+E +L+ E E K + E+
Sbjct: 2460 EKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2518
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLA------------EERARREEEENRRK 167
L +D + + + R EQQR + + E+ERQ +A EE RR++EE ++
Sbjct: 2519 L--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2576
Query: 168 AEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLA 220
+ ++++ L+ + +R + Q E+ + LA +V A
Sbjct: 2577 EQQRRQQEELLAE------------ENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Score = 28.5 bits (62), Expect = 7.2
Identities = 37/174 (21%), Positives = 63/174 (36%), Gaps = 23/174 (13%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQ--EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
IE+ + E+ Q+E A +Q EE + + E E + A +E EAE+G
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
+ + + + +R +++ + ++ +LQ L E H EE
Sbjct: 2569 KQEELQQL-----------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Query: 122 SL----------KDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENR 165
S +D ++ AE + R K RL E EE R
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2671
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 68.2 bits (165), Expect = 8e-12
Identities = 78/309 (25%), Positives = 142/309 (45%), Gaps = 47/309 (15%)
Query: 1 MSDIEEVVEEYEEEEQE-----EAAVEEQEEAAEEDAEAEAETE-ETRAEEDEEEEEAKE 54
M + E + E+ EE+E EAA+E+Q + AE A+A+A+ E E + + +EE
Sbjct: 1348 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407
Query: 55 AEDGPMEESKPKPRSFMPNLVPPKIPD-------GERVDFDDIHRKRMEKDLNELQALIE 107
E+ ++ + K RS L + + + + R R+E+++ ++ +E
Sbjct: 1408 REEAAVDAQQQK-RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466
Query: 108 AHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEE---- 163
A R E EL +L R RAE AE Q+ + + E ER R ++ ++R+ +
Sbjct: 1467 ATERQRGGAEGELQAL-----RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1521
Query: 164 -NRRKAEDEA--RKKKALSNMMHFGGYIQ------KQAQTER--------KSGKRQTERE 206
+R KAE EA K++AL + + +QA+ ER ++ +R E E
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1581
Query: 207 KKKK------ILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYE 260
+ K A+ + L +H+ QLRE+A+ Q E + + + + ++ + +
Sbjct: 1582 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1641
Query: 261 IN-VLRNRI 268
N LR R+
Sbjct: 1642 ANEALRLRL 1650
Score = 53.5 bits (127), Expect = 2e-07
Identities = 67/303 (22%), Positives = 129/303 (42%), Gaps = 29/303 (9%)
Query: 12 EEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFM 71
E+ Q +A +EE+ + +++E E ++ E+ + E E ++ S K +
Sbjct: 1886 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1945
Query: 72 PNLVPPKIPDGE-RVDFDDIHRKRMEKDLNEL-QALIEAHFENRKKEEEELV--SLKDRI 127
L ++ G R + +D R + + +L Q + A E R++E EE V SL
Sbjct: 1946 AEL---ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2002
Query: 128 ERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGY 187
E R +A + + + K + R ERA +E + A++ A+K+ H
Sbjct: 2003 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2062
Query: 188 IQK----------------QAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNE-DQLR 230
QK Q + E ++ +R E ++ ++ AER + + E ++L+
Sbjct: 2063 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2122
Query: 231 EKAKELWQSIYNLEAEKFDL-----QEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTG 285
+ A+E Q+ +A L QE ++ + E LR + + ++ K + A+ T
Sbjct: 2123 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182
Query: 286 RWK 288
R K
Sbjct: 2183 RQK 2185
Score = 53.5 bits (127), Expect = 2e-07
Identities = 66/277 (23%), Positives = 123/277 (44%), Gaps = 45/277 (16%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
+ + E + + EE+ Q A + E ++AE EA RA+ ++ K+A D M
Sbjct: 2115 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQAALRQKQAADAEM 2171
Query: 61 EESKPKPRSFMPNLVPPKIPDGE-------RVDFDDIHRKRMEKDLNELQALIEAHFENR 113
E K + F + K + +++ D + ++++L L+A R
Sbjct: 2172 E----KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2227
Query: 114 KKEEEELVS----------LKDRIERRR-----AERAEQQRIRNEREKERQNRLAEERAR 158
+ EEEL S LK RIE ++ QR E E E+ ++AEE AR
Sbjct: 2228 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAAR 2286
Query: 159 -----REEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTERE---KKKK 210
+E R+ AE++ +++AL+ M ++++ Q +++ + + E E ++K+
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALAEKM-----LKEKMQAVQEATRLKAEAELLQQQKE 2341
Query: 211 ILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEK 247
+ E+ + L D E ++ A+E LEAE+
Sbjct: 2342 LAQEQARRLQED--KEQMAQQLAEETQGFQRTLEAER 2376
Score = 52.8 bits (125), Expect = 4e-07
Identities = 63/264 (23%), Positives = 113/264 (42%), Gaps = 39/264 (14%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE E EE+ + ++ +EEAA + A E E +A+ +E + AE + +
Sbjct: 1982 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2041
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ L + H +++ ELQ ++ +E+ L L+
Sbjct: 2042 LAQEAAQKRLQAE----------EKAHAFAVQQKEQELQQTLQ-------QEQSVLDQLR 2084
Query: 125 DRIE--RRRAERAEQQRIRNEREKERQNRLAEERARRE---EEENRRKAEDEARKKKALS 179
E RR AE AE+ R++ ERE + R EE R + EE+ + +A+ +A +K
Sbjct: 2085 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK--- 2141
Query: 180 NMMHFGGYIQKQAQTE--RKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAK-EL 236
++K+A+ E R++ Q +K+ AE K E LR+KA+ E
Sbjct: 2142 --------LRKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQ 2190
Query: 237 WQSIYNLEAEKFDLQEKFKQQKYE 260
+ L+ E+ D Q+ ++ +
Sbjct: 2191 ELTTLRLQLEETDHQKNLLDEELQ 2214
Score = 51.6 bits (122), Expect = 8e-07
Identities = 68/313 (21%), Positives = 131/313 (41%), Gaps = 50/313 (15%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETE------------------------- 39
EE V + E+ E ++Q EA EAE E E
Sbjct: 1602 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1661
Query: 40 -ETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKD 98
+ AE+ +EE E + G EE + R + + + + R E++
Sbjct: 1662 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQQRLAAEQE 1718
Query: 99 LNELQALIEAHFENRKKEEEELVSLKDR----IERRRAERAEQQRIRNEREKERQNRL-A 153
L L+A E + R+ EEEL L+ ++R+ AE ++R E E ++ A
Sbjct: 1719 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1778
Query: 154 EERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREK--KKKI 211
EE +R E+++++ E EA + + L+ + ++A+ +R+ + R++ +++
Sbjct: 1779 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1838
Query: 212 LAERRKVLAIDHLN------EDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLR 265
LAE K+ AI E L+EK E N + E F++++ E +
Sbjct: 1839 LAE--KLAAIGEATRLKTEAEIALKEKEAE------NERLRRLAEDEAFQRRRLEEQAAQ 1890
Query: 266 NRINDNQKVSKTR 278
++ + +++++ R
Sbjct: 1891 HKADIEERLAQLR 1903
Score = 49.3 bits (116), Expect = 4e-06
Identities = 60/243 (24%), Positives = 106/243 (43%), Gaps = 58/243 (23%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNL 74
++E AV + E AE A+ +AE E R E + E E +
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ--------------------- 1639
Query: 75 VPPKIPDGERVDFDDIHRKRME-KDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAE 133
+ ++ R R++ +++ + ++L +A E +K+E E E RR
Sbjct: 1640 ----------LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER--------EARRRG 1681
Query: 134 RAEQQRIRN----EREKERQNRLAE----ERARREEEENRRKAEDE--ARKKKALSNMMH 183
+AE+Q +R E+E E+Q +LAE +R E+E R +AE E ++++ L +
Sbjct: 1682 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL- 1740
Query: 184 FGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNL 243
+ Q + + KRQ + K+ AE +LA E++ R ++ +S L
Sbjct: 1741 ----ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE---KSKQRL 1793
Query: 244 EAE 246
EAE
Sbjct: 1794 EAE 1796
Score = 48.5 bits (114), Expect = 7e-06
Identities = 72/294 (24%), Positives = 126/294 (42%), Gaps = 45/294 (15%)
Query: 2 SDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEE--------EEAK 53
+++ +V E E +A EE+ + E ++ E E R E EE EEAK
Sbjct: 1759 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818
Query: 54 EAEDGPMEESKPKPRSFMPNLVPPK---IPDGERVDFD-DIHRKRMEKDLNELQALIEAH 109
EE + R+ ++ K I + R+ + +I K E + L+ L E
Sbjct: 1819 RQRQ-LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1877
Query: 110 FENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAE 169
R++ EE+ K IE ER Q R ++ E ERQ L E+ R+ RR+ E
Sbjct: 1878 AFQRRRLEEQAAQHKADIE----ERLAQLRKASDSELERQKGLVEDTLRQ-----RRQVE 1928
Query: 170 DEARKKKALSNMMHFG--------GYIQKQAQ-TERKSGKRQTEREKKKKILAERRKVLA 220
+E KA G G I+ A+ T R + + E +++++ AE
Sbjct: 1929 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE------ 1982
Query: 221 IDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKV 274
E++ R +A+E Q +L AE+ +++ K E+ L+ ++ + +++
Sbjct: 1983 -----EERRRREAEERVQK--SLAAEEEAARQR-KAALEEVERLKAKVEEARRL 2028
Score = 46.2 bits (108), Expect = 3e-05
Identities = 57/251 (22%), Positives = 109/251 (43%), Gaps = 28/251 (11%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQ--------EEAAEEDAEAEAETEETRAEEDEEEEEAKEA 55
+++ +E ++ Q+E +V +Q AAEE EA + E A+ + EEA+
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2121
Query: 56 EDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKK 115
+ E+++ + ++ K+ + + + R + E+ + +A E KK
Sbjct: 2122 KQSAEEQAQARAQA---QAAAEKL--RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2176
Query: 116 EEEELVSLKDRIE------RRRAERAEQQRIRNEREKERQNRLAEERARR-----EEEEN 164
E+ + K ++E R + E + Q+ + E +R A E AR+ EE +
Sbjct: 2177 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2236
Query: 165 RRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHL 224
R +E K KA + ++ + T+R Q E EK K++ AE L++
Sbjct: 2237 VRVQMEELSKLKARIEAENRALILRDKDNTQR---FLQEEAEKMKQV-AEEAARLSVAAQ 2292
Query: 225 NEDQLREKAKE 235
+LR+ A+E
Sbjct: 2293 EAARLRQLAEE 2303
Score = 44.3 bits (103), Expect = 1e-04
Identities = 53/224 (23%), Positives = 98/224 (43%), Gaps = 31/224 (13%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+I E + E QE+ + + E + ++ +AE E E E+E + E
Sbjct: 2416 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE------ 2469
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKR---MEKDLNELQALI--EAHFENRKKEE 117
L+ K + + V + + ++ + L+E +L+ E E K +
Sbjct: 2470 ---------AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2520
Query: 118 EELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE-ERARREEEENRRKAEDEARKKK 176
E+L +D + + + R EQQR + + E+ERQ +A E ARR + E AE+ R+K+
Sbjct: 2521 EQL--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQ 2574
Query: 177 ALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLA 220
+ Q++ Q E + + Q RE+ + + + R LA
Sbjct: 2575 EELQQLE----QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2614
Score = 41.6 bits (96), Expect = 8e-04
Identities = 58/302 (19%), Positives = 130/302 (43%), Gaps = 37/302 (12%)
Query: 6 EVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKP 65
+ V+E + E +++Q+E A+E A E +E A++ EE + + +E +
Sbjct: 2321 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR---TLEAERQ 2377
Query: 66 KPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEE---EELVS 122
+ K+ RV + R E+D + E E + E +E V+
Sbjct: 2378 RQLEMSAEAERLKL----RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2433
Query: 123 LKDRIERRR------AERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKK 176
L +E +R AER + EREKE+ + A+ + EE + E ++ +
Sbjct: 2434 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2493
Query: 177 AL--SNMMHFGGYIQKQAQTERKSGK---------------RQTEREKKKKILAERRKVL 219
AL S + +Q++ E++ K R+ ++ +++++ ER++++
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553
Query: 220 AIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRG 279
A + ++ R + E + + + E L+++ +QQ+ + R+ + ++ + +
Sbjct: 2554 A----SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2609
Query: 280 KA 281
+A
Sbjct: 2610 RA 2611
Score = 41.6 bits (96), Expect = 8e-04
Identities = 47/233 (20%), Positives = 100/233 (42%), Gaps = 32/233 (13%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE + + ++ +E + E A ++ +T E + ++ + + E +E K
Sbjct: 2404 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2463
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRM---EKDLNELQALI--EAHFENRKKEEEE 119
K + L+ K + + V + + ++ + L+E +L+ E E K + E+
Sbjct: 2464 EKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2522
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLA------------EERARREEEENRRK 167
L +D + + + R EQQR + + E+ERQ +A EE RR++EE ++
Sbjct: 2523 L--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2580
Query: 168 AEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLA 220
+ ++++ L+ + +R + Q E+ + LA +V A
Sbjct: 2581 EQQRRQQEELLAE------------ENQRLREQLQLLEEQHRAALAHSEEVTA 2621
Score = 28.5 bits (62), Expect = 7.2
Identities = 37/174 (21%), Positives = 63/174 (36%), Gaps = 23/174 (13%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQ--EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
IE+ + E+ Q+E A +Q EE + + E E + A +E EAE+G
Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2572
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
+ + + + +R +++ + ++ +LQ L E H EE
Sbjct: 2573 KQEELQQL-----------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2621
Query: 122 SL----------KDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENR 165
S +D ++ AE + R K RL E EE R
Sbjct: 2622 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2675
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 68.2 bits (165), Expect = 8e-12
Identities = 78/309 (25%), Positives = 142/309 (45%), Gaps = 47/309 (15%)
Query: 1 MSDIEEVVEEYEEEEQE-----EAAVEEQEEAAEEDAEAEAETE-ETRAEEDEEEEEAKE 54
M + E + E+ EE+E EAA+E+Q + AE A+A+A+ E E + + +EE
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 55 AEDGPMEESKPKPRSFMPNLVPPKIPD-------GERVDFDDIHRKRMEKDLNELQALIE 107
E+ ++ + K RS L + + + + R R+E+++ ++ +E
Sbjct: 1404 REEAAVDAQQQK-RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 108 AHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEE---- 163
A R E EL +L R RAE AE Q+ + + E ER R ++ ++R+ +
Sbjct: 1463 ATERQRGGAEGELQAL-----RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 164 -NRRKAEDEA--RKKKALSNMMHFGGYIQ------KQAQTER--------KSGKRQTERE 206
+R KAE EA K++AL + + +QA+ ER ++ +R E E
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1577
Query: 207 KKKK------ILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYE 260
+ K A+ + L +H+ QLRE+A+ Q E + + + + ++ + +
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637
Query: 261 IN-VLRNRI 268
N LR R+
Sbjct: 1638 ANEALRLRL 1646
Score = 53.5 bits (127), Expect = 2e-07
Identities = 67/303 (22%), Positives = 129/303 (42%), Gaps = 29/303 (9%)
Query: 12 EEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFM 71
E+ Q +A +EE+ + +++E E ++ E+ + E E ++ S K +
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 72 PNLVPPKIPDGE-RVDFDDIHRKRMEKDLNEL-QALIEAHFENRKKEEEELV--SLKDRI 127
L ++ G R + +D R + + +L Q + A E R++E EE V SL
Sbjct: 1942 AEL---ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998
Query: 128 ERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGY 187
E R +A + + + K + R ERA +E + A++ A+K+ H
Sbjct: 1999 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2058
Query: 188 IQK----------------QAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNE-DQLR 230
QK Q + E ++ +R E ++ ++ AER + + E ++L+
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 231 EKAKELWQSIYNLEAEKFDL-----QEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTG 285
+ A+E Q+ +A L QE ++ + E LR + + ++ K + A+ T
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 286 RWK 288
R K
Sbjct: 2179 RQK 2181
Score = 53.5 bits (127), Expect = 2e-07
Identities = 66/277 (23%), Positives = 123/277 (44%), Gaps = 45/277 (16%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
+ + E + + EE+ Q A + E ++AE EA RA+ ++ K+A D M
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQAALRQKQAADAEM 2167
Query: 61 EESKPKPRSFMPNLVPPKIPDGE-------RVDFDDIHRKRMEKDLNELQALIEAHFENR 113
E K + F + K + +++ D + ++++L L+A R
Sbjct: 2168 E----KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Query: 114 KKEEEELVS----------LKDRIERRR-----AERAEQQRIRNEREKERQNRLAEERAR 158
+ EEEL S LK RIE ++ QR E E E+ ++AEE AR
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAAR 2282
Query: 159 -----REEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTERE---KKKK 210
+E R+ AE++ +++AL+ M ++++ Q +++ + + E E ++K+
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKM-----LKEKMQAVQEATRLKAEAELLQQQKE 2337
Query: 211 ILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEK 247
+ E+ + L D E ++ A+E LEAE+
Sbjct: 2338 LAQEQARRLQED--KEQMAQQLAEETQGFQRTLEAER 2372
Score = 52.8 bits (125), Expect = 4e-07
Identities = 63/264 (23%), Positives = 113/264 (42%), Gaps = 39/264 (14%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE E EE+ + ++ +EEAA + A E E +A+ +E + AE + +
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ L + H +++ ELQ ++ +E+ L L+
Sbjct: 2038 LAQEAAQKRLQAE----------EKAHAFAVQQKEQELQQTLQ-------QEQSVLDQLR 2080
Query: 125 DRIE--RRRAERAEQQRIRNEREKERQNRLAEERARRE---EEENRRKAEDEARKKKALS 179
E RR AE AE+ R++ ERE + R EE R + EE+ + +A+ +A +K
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK--- 2137
Query: 180 NMMHFGGYIQKQAQTE--RKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAK-EL 236
++K+A+ E R++ Q +K+ AE K E LR+KA+ E
Sbjct: 2138 --------LRKEAEQEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQ 2186
Query: 237 WQSIYNLEAEKFDLQEKFKQQKYE 260
+ L+ E+ D Q+ ++ +
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQ 2210
Score = 51.6 bits (122), Expect = 8e-07
Identities = 68/313 (21%), Positives = 131/313 (41%), Gaps = 50/313 (15%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETE------------------------- 39
EE V + E+ E ++Q EA EAE E E
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1657
Query: 40 -ETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKD 98
+ AE+ +EE E + G EE + R + + + + R E++
Sbjct: 1658 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQQRLAAEQE 1714
Query: 99 LNELQALIEAHFENRKKEEEELVSLKDR----IERRRAERAEQQRIRNEREKERQNRL-A 153
L L+A E + R+ EEEL L+ ++R+ AE ++R E E ++ A
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774
Query: 154 EERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREK--KKKI 211
EE +R E+++++ E EA + + L+ + ++A+ +R+ + R++ +++
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 212 LAERRKVLAIDHLN------EDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLR 265
LAE K+ AI E L+EK E N + E F++++ E +
Sbjct: 1835 LAE--KLAAIGEATRLKTEAEIALKEKEAE------NERLRRLAEDEAFQRRRLEEQAAQ 1886
Query: 266 NRINDNQKVSKTR 278
++ + +++++ R
Sbjct: 1887 HKADIEERLAQLR 1899
Score = 49.3 bits (116), Expect = 4e-06
Identities = 60/243 (24%), Positives = 106/243 (43%), Gaps = 58/243 (23%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNL 74
++E AV + E AE A+ +AE E R E + E E +
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ--------------------- 1635
Query: 75 VPPKIPDGERVDFDDIHRKRME-KDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAE 133
+ ++ R R++ +++ + ++L +A E +K+E E E RR
Sbjct: 1636 ----------LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER--------EARRRG 1677
Query: 134 RAEQQRIRN----EREKERQNRLAE----ERARREEEENRRKAEDE--ARKKKALSNMMH 183
+AE+Q +R E+E E+Q +LAE +R E+E R +AE E ++++ L +
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL- 1736
Query: 184 FGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNL 243
+ Q + + KRQ + K+ AE +LA E++ R ++ +S L
Sbjct: 1737 ----ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE---KSKQRL 1789
Query: 244 EAE 246
EAE
Sbjct: 1790 EAE 1792
Score = 48.5 bits (114), Expect = 7e-06
Identities = 72/294 (24%), Positives = 126/294 (42%), Gaps = 45/294 (15%)
Query: 2 SDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEE--------EEAK 53
+++ +V E E +A EE+ + E ++ E E R E EE EEAK
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 54 EAEDGPMEESKPKPRSFMPNLVPPK---IPDGERVDFD-DIHRKRMEKDLNELQALIEAH 109
EE + R+ ++ K I + R+ + +I K E + L+ L E
Sbjct: 1815 RQRQ-LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1873
Query: 110 FENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAE 169
R++ EE+ K IE ER Q R ++ E ERQ L E+ R+ RR+ E
Sbjct: 1874 AFQRRRLEEQAAQHKADIE----ERLAQLRKASDSELERQKGLVEDTLRQ-----RRQVE 1924
Query: 170 DEARKKKALSNMMHFG--------GYIQKQAQ-TERKSGKRQTEREKKKKILAERRKVLA 220
+E KA G G I+ A+ T R + + E +++++ AE
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE------ 1978
Query: 221 IDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKV 274
E++ R +A+E Q +L AE+ +++ K E+ L+ ++ + +++
Sbjct: 1979 -----EERRRREAEERVQK--SLAAEEEAARQR-KAALEEVERLKAKVEEARRL 2024
Score = 46.2 bits (108), Expect = 3e-05
Identities = 57/251 (22%), Positives = 109/251 (43%), Gaps = 28/251 (11%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQ--------EEAAEEDAEAEAETEETRAEEDEEEEEAKEA 55
+++ +E ++ Q+E +V +Q AAEE EA + E A+ + EEA+
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117
Query: 56 EDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKK 115
+ E+++ + ++ K+ + + + R + E+ + +A E KK
Sbjct: 2118 KQSAEEQAQARAQA---QAAAEKL--RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 116 EEEELVSLKDRIE------RRRAERAEQQRIRNEREKERQNRLAEERARR-----EEEEN 164
E+ + K ++E R + E + Q+ + E +R A E AR+ EE +
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 165 RRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHL 224
R +E K KA + ++ + T+R Q E EK K++ AE L++
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQR---FLQEEAEKMKQV-AEEAARLSVAAQ 2288
Query: 225 NEDQLREKAKE 235
+LR+ A+E
Sbjct: 2289 EAARLRQLAEE 2299
Score = 44.3 bits (103), Expect = 1e-04
Identities = 53/224 (23%), Positives = 98/224 (43%), Gaps = 31/224 (13%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+I E + E QE+ + + E + ++ +AE E E E+E + E
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE------ 2465
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKR---MEKDLNELQALI--EAHFENRKKEE 117
L+ K + + V + + ++ + L+E +L+ E E K +
Sbjct: 2466 ---------AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 118 EELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE-ERARREEEENRRKAEDEARKKK 176
E+L +D + + + R EQQR + + E+ERQ +A E ARR + E AE+ R+K+
Sbjct: 2517 EQL--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQ 2570
Query: 177 ALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLA 220
+ Q++ Q E + + Q RE+ + + + R LA
Sbjct: 2571 EELQQLE----QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2610
Score = 41.6 bits (96), Expect = 8e-04
Identities = 58/302 (19%), Positives = 130/302 (43%), Gaps = 37/302 (12%)
Query: 6 EVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKP 65
+ V+E + E +++Q+E A+E A E +E A++ EE + + +E +
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR---TLEAERQ 2373
Query: 66 KPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEE---EELVS 122
+ K+ RV + R E+D + E E + E +E V+
Sbjct: 2374 RQLEMSAEAERLKL----RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2429
Query: 123 LKDRIERRR------AERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKK 176
L +E +R AER + EREKE+ + A+ + EE + E ++ +
Sbjct: 2430 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQ 2489
Query: 177 AL--SNMMHFGGYIQKQAQTERKSGK---------------RQTEREKKKKILAERRKVL 219
AL S + +Q++ E++ K R+ ++ +++++ ER++++
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 220 AIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRG 279
A + ++ R + E + + + E L+++ +QQ+ + R+ + ++ + +
Sbjct: 2550 A----SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605
Query: 280 KA 281
+A
Sbjct: 2606 RA 2607
Score = 41.6 bits (96), Expect = 8e-04
Identities = 47/233 (20%), Positives = 100/233 (42%), Gaps = 32/233 (13%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE + + ++ +E + E A ++ +T E + ++ + + E +E K
Sbjct: 2400 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRM---EKDLNELQALI--EAHFENRKKEEEE 119
K + L+ K + + V + + ++ + L+E +L+ E E K + E+
Sbjct: 2460 EKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2518
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLA------------EERARREEEENRRK 167
L +D + + + R EQQR + + E+ERQ +A EE RR++EE ++
Sbjct: 2519 L--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2576
Query: 168 AEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLA 220
+ ++++ L+ + +R + Q E+ + LA +V A
Sbjct: 2577 EQQRRQQEELLAE------------ENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Score = 28.5 bits (62), Expect = 7.2
Identities = 37/174 (21%), Positives = 63/174 (36%), Gaps = 23/174 (13%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQ--EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
IE+ + E+ Q+E A +Q EE + + E E + A +E EAE+G
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
+ + + + +R +++ + ++ +LQ L E H EE
Sbjct: 2569 KQEELQQL-----------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Query: 122 SL----------KDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENR 165
S +D ++ AE + R K RL E EE R
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2671
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.124 0.322
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,189,617
Number of Sequences: 37866
Number of extensions: 637996
Number of successful extensions: 44055
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1308
Number of HSP's successfully gapped in prelim test: 1208
Number of HSP's that attempted gapping in prelim test: 7391
Number of HSP's gapped (non-prelim): 14464
length of query: 288
length of database: 18,247,518
effective HSP length: 101
effective length of query: 187
effective length of database: 14,423,052
effective search space: 2697110724
effective search space used: 2697110724
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.