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Search of human proteins with 4759082
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4759082 serum deprivation response protein [Homo sapiens]
(425 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4759082 serum deprivation response protein [Homo sapiens] 816 0.0
gi|42734430 polymerase I and transcript release factor [Homo sap... 217 1e-56
gi|66472922 muscle-related coiled-coil protein [Homo sapiens] 157 2e-38
gi|47132587 protein kinase C, delta binding protein [Homo sapiens] 135 9e-32
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 53 5e-07
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 53 5e-07
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 52 1e-06
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 50 4e-06
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 50 5e-06
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 49 7e-06
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 48 1e-05
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 48 2e-05
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 48 2e-05
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 48 2e-05
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 48 2e-05
gi|221219020 NYD-SP11 protein [Homo sapiens] 47 3e-05
gi|38569484 kinesin family member 21A [Homo sapiens] 46 6e-05
gi|38045919 huntingtin interacting protein 1 [Homo sapiens] 46 6e-05
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 46 7e-05
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 46 7e-05
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 45 1e-04
gi|197313732 pleckstrin homology-like domain, family B, member 2... 45 1e-04
gi|197313730 pleckstrin homology-like domain, family B, member 2... 45 1e-04
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 45 1e-04
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 45 1e-04
gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo ... 45 1e-04
gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo s... 45 1e-04
gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo sa... 45 1e-04
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 45 2e-04
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 45 2e-04
>gi|4759082 serum deprivation response protein [Homo sapiens]
Length = 425
Score = 816 bits (2109), Expect = 0.0
Identities = 425/425 (100%), Positives = 425/425 (100%)
Query: 1 MGEDAAQAEKFQHPGSDMRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLT 60
MGEDAAQAEKFQHPGSDMRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLT
Sbjct: 1 MGEDAAQAEKFQHPGSDMRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLT 60
Query: 61 LLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRK 120
LLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRK
Sbjct: 61 LLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRK 120
Query: 121 VSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAV 180
VSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAV
Sbjct: 121 VSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAV 180
Query: 181 EGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVD 240
EGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVD
Sbjct: 181 EGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVD 240
Query: 241 SLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRK 300
SLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRK
Sbjct: 241 SLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRK 300
Query: 301 KVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEKAT 360
KVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEKAT
Sbjct: 301 KVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEKAT 360
Query: 361 SRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDGDPVQPAVLQ 420
SRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDGDPVQPAVLQ
Sbjct: 361 SRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDGDPVQPAVLQ 420
Query: 421 VHQTS 425
VHQTS
Sbjct: 421 VHQTS 425
>gi|42734430 polymerase I and transcript release factor [Homo
sapiens]
Length = 390
Score = 217 bits (553), Expect = 1e-56
Identities = 143/378 (37%), Positives = 212/378 (56%), Gaps = 60/378 (15%)
Query: 23 PSSPSPMPSSTPSPSLN--LGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKME 80
P + +P PSS + + G E + + QVN V VL+LLDK++ +D +Q Q ++E
Sbjct: 17 PDAEAPEPSSAGAQAAEEPSGAGSEELIKSDQVNGVLVLSLLDKIIGAVDQIQLTQAQLE 76
Query: 81 QRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQVK 140
+RQ +EG+V+ IQ +L+KL K A+TSNTVSKLLEK RKVS + + V+ ++RQ Q+K
Sbjct: 77 ERQAEMEGAVQSIQGELSKLGKAHATTSNTVSKLLEKVRKVSVNVKTVRGSLERQAGQIK 136
Query: 141 RLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPD-------ENKSL 193
+LE N A+LLRR +FKV+I+Q+E ++PA K +S +++ E LP+ E +
Sbjct: 137 KLEVNEAELLRRRNFKVMIYQDEVKLPA----KLSISKSLKESEALPEKEGEELGEGERP 192
Query: 194 EETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFS------ 247
EE ++LSSD EA+E EE +EESRAE+IKRS L++VD KKAFS
Sbjct: 193 EEDAAALELSSD-------EAVE--VEEVIEESRAERIKRSGLRRVDDFKKAFSKEKMEK 243
Query: 248 -----------------------RQNIEKKMNKLGTKIVSVERREKIK-------KSLTS 277
R +EK+MNKLGT++V ERREK+K KS T
Sbjct: 244 TKVRTRENLEKTRLKTKENLEKTRHTLEKRMNKLGTRLVPAERREKLKTSRDKLRKSFTP 303
Query: 278 NHQKISSGKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGH 337
+H + K++ +KV P TF KK+REG+ T+ ++ + + + E+
Sbjct: 304 DHVVYARSKTAVYKVPPFTFHVKKIREGQVEVLKATEMVEVGADDDEGGAERGEAGDLRR 363
Query: 338 SEASLASALVEGEIAEEA 355
+ AL+ EI EE+
Sbjct: 364 GSSPDVHALL--EITEES 379
>gi|66472922 muscle-related coiled-coil protein [Homo sapiens]
Length = 364
Score = 157 bits (396), Expect = 2e-38
Identities = 105/330 (31%), Positives = 186/330 (56%), Gaps = 48/330 (14%)
Query: 31 SSTPSPSLNLGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSV 90
S++ + ++ D Q A+T++T+LDK+ +++D+VQ +Q ++E+R +E ++
Sbjct: 6 SASNADKIHQNRLSSVTEDEDQDAALTIVTVLDKVASIVDSVQASQKRIEERHREMENAI 65
Query: 91 KGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLL 150
K +Q DL KLS+ ++T + ++KL EK+RKVSAH + VK R+++Q VK++E +++
Sbjct: 66 KSVQIDLLKLSQSHSNTGHIINKLFEKTRKVSAHIKDVKARVEKQQIHVKKVEVKQEEIM 125
Query: 151 RRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPH 210
++N F+V+IFQE+ P S+ V + E +EE D++ + VDLSSD+
Sbjct: 126 KKNKFRVVIFQEKFRCPTSLSVVKD-RNLTENQEE--DDDDIFDP---PVDLSSDE---- 175
Query: 211 DEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFS-------RQNIEKKMNKLGTKIV 263
E VEESR+ ++++S + +D++KKAFS RQN++KK+N++ T+IV
Sbjct: 176 ---------EYYVEESRSARLRKSGKEHIDNIKKAFSKENMQKTRQNLDKKVNRIRTRIV 226
Query: 264 SVERREKIKKS------------LTSNHQKISSGKSSP----FKVSPLTFGR-KKVREGE 306
+ ERRE++++S + K S ++P FK+ L G+ + V EGE
Sbjct: 227 TPERRERLRQSGERLRQSGERLRQSGERFKKSISNAAPSKEAFKMRSLRKGKDRTVAEGE 286
Query: 307 SHAENE-----TKSEDLPSSEQMPNDQEEE 331
A +SE L ++ +D+ E
Sbjct: 287 ECAREMGVDIIARSESLGPISELYSDELSE 316
>gi|47132587 protein kinase C, delta binding protein [Homo sapiens]
Length = 261
Score = 135 bits (339), Expect = 9e-32
Identities = 79/195 (40%), Positives = 119/195 (61%), Gaps = 20/195 (10%)
Query: 53 VNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVS 112
V+AVTV+TLL+KL +ML+ ++E Q + +RQ L GSV+ IQ+ L LS+ +TSNT++
Sbjct: 20 VHAVTVVTLLEKLASMLETLRERQGGLARRQGGLAGSVRRIQSGLGALSRSHDTTSNTLA 79
Query: 113 KLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFV 172
+LL K+ +VS+H A +ER R+ AQV+RLE NH L+ R VL+F+EE E+PAS F
Sbjct: 80 QLLAKAERVSSHANAAQERAVRRAAQVQRLEANHGLLVARGKLHVLLFKEEGEVPASAFQ 139
Query: 173 KQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIK 232
K P + EL E E + +S++E+ ESRA++++
Sbjct: 140 KAPEPLGPADQSELGPEQLEAE--------------------VGESSDEEPVESRAQRLR 179
Query: 233 RSSLKKVDSLKKAFS 247
R+ L+KV SL++A S
Sbjct: 180 RTGLQKVQSLRRALS 194
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 53.1 bits (126), Expect = 5e-07
Identities = 90/411 (21%), Positives = 173/411 (42%), Gaps = 76/411 (18%)
Query: 40 LGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQH------KMEQR-QISLEGSVKG 92
L T E +R+NS+ + + +L+ QEN+H + QR QIS E VK
Sbjct: 538 LEKTIETLRENSE-----------RQIKILE--QENEHLNQTVSSLRQRSQISAEARVKD 584
Query: 93 IQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRR 152
I+ + L + TS+ +SK+ + R++ KE+ +R + LEN L +
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGER----AEELENELHHLEKE 640
Query: 153 NHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDE 212
N + +I + + + EL EN+ L++T L S +L
Sbjct: 641 NELL------QKKITNLKITCEKIEALEQENSELERENRKLKKT-----LDSFKNLTFQL 689
Query: 213 EALEDSAEEKVEES-----RAEKIKRSSLK----KVDSLKKAFSRQNIEKKMNKLGTKIV 263
E+LE + EE+ E +K +S+K ++++ + ++ ++K + L
Sbjct: 690 ESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
Query: 264 SVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREGES-----HAENETKSEDL 318
ER E + L +Q++ L KK+++ ES EN+T ++L
Sbjct: 750 KTERLEVSYQGLDIENQRLQ---------KTLENSNKKIQQLESELQDLEMENQTLQKNL 800
Query: 319 P----SSEQMPN-DQEEESFAEGHSEASLASALVEGE---IAEEAAEKATSRGSNSGMDS 370
SS+++ ++E +S + S+ +E E + ++A K T+ N+
Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860
Query: 371 NIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDGDPVQPAVLQV 421
N+ E+E+ L + + E L +E E+ + + V+ A + +
Sbjct: 861 NL--------EKENKTLSKEIGIYKESCVRL--KELEKENKELVKRATIDI 901
Score = 39.7 bits (91), Expect = 0.005
Identities = 71/354 (20%), Positives = 147/354 (41%), Gaps = 50/354 (14%)
Query: 69 LDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNT--------VSKLLEKSRK 120
L+ +++ +EQ LE K ++ + +L + QA +T + L ++++
Sbjct: 810 LEQLEKENKSLEQETSQLEKDKKQLEKENKRL-RQQAEIKDTTLEENNVKIGNLEKENKT 868
Query: 121 VSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAV 180
+S KE C ++K LE + +L++R +I V +++ +
Sbjct: 869 LSKEIGIYKE----SCVRLKELEKENKELVKRATI---------DIKTLVTLREDLVSEK 915
Query: 181 EGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVD 240
+++ ++ + L L + L+ + L HDE++ +DS K+ ES+ E + SL ++
Sbjct: 916 LKTQQMNNDLEKLTHELEKIGLNKER-LLHDEQSTDDS-RYKLLESKLESTLKKSL-EIK 972
Query: 241 SLKKAFSRQNIEKKMN---KLGTKIVSVERREKIKKSLTSNHQKISSG-----------K 286
K A +E+ N +L ++ +V++ + K + + S +
Sbjct: 973 EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1032
Query: 287 SSPFKVSPLTFGRKKVREGESH-----AENETKSEDLPSSEQMPNDQEEESFAEGHSEAS 341
S L + ++ E E + AE + L E N+ + + A S
Sbjct: 1033 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1092
Query: 342 L--ASALVEGEIAEEAAEKAT-SRGSNSGMDSNIDLTIVE---DEEEESVALEQ 389
L + ++ + A+ E +T + S S M+ N L I + + E ESV E+
Sbjct: 1093 LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKER 1146
Score = 32.0 bits (71), Expect = 1.1
Identities = 65/283 (22%), Positives = 115/283 (40%), Gaps = 32/283 (11%)
Query: 69 LDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLE-KSRKV-----S 122
L V++N ++QRQ E V+ + +K++ + T +LL+ K R + +
Sbjct: 997 LKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1055
Query: 123 AHTRAVKERMDRQCAQVKRLENN-HAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVE 181
A +A K+ + Q Q++ NN AQ+L + + QE+N + K V +
Sbjct: 1056 ATLQAEKQALKTQLKQLETQNNNLQAQILALQR-QTVSLQEQNTTLQTQNAKLQVENSTL 1114
Query: 182 GKE---------ELPDENKSLEETLHTV-----DLSS-DDDLPHDEEALEDSAEEKVEES 226
+ +L + SLE +V DL S D L D E LE E + E
Sbjct: 1115 NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEY 1174
Query: 227 RAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGK 286
+ K +LK +++E + N+L + + E ++K L +K+
Sbjct: 1175 ESLISKHGTLKSAHK-NLEVEHRDLEDRYNQL---LKQKGQLEDLEKMLKVEQEKMLLEN 1230
Query: 287 SSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQE 329
+ V+ K GE+ N T S+ L +E + D +
Sbjct: 1231 KNHETVA----AEYKKLCGENDRLNHTYSQLLKETEVLQTDHK 1269
Score = 31.2 bits (69), Expect = 1.9
Identities = 55/236 (23%), Positives = 101/236 (42%), Gaps = 22/236 (9%)
Query: 184 EELPDENKSLEETLHTVDLSSDDD----LPHDEEALEDSAEEKVEESRAEKIKRSSLKKV 239
+ L DE ET+ ++LS + D LPH + + + R E + S++
Sbjct: 198 KRLIDERDEHSETI--IELSEERDGLHFLPHASSSAQSPCGSPGMK-RTESRQHLSVELA 254
Query: 240 DSLKKAFS-RQNIEKKMNKLGTKIVSVERRE-KIKKSLTSNHQKISSGKSSPFKVSPLTF 297
D+ K RQ +E+K +L +E+ E ++K+ N +S +S+ L
Sbjct: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA 314
Query: 298 GRKK-VREGESHAENETKSEDLPSSE-------QMPNDQ----EEESFAEGHSEASLASA 345
R+K VR + +E E L E ++ D E ++ E E + A +
Sbjct: 315 LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS 374
Query: 346 LVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYAL 401
E+ +E + ++ + M+ ++D +E+ EE++ LE AQK + S L
Sbjct: 375 DKLHELEKENLQ-LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 53.1 bits (126), Expect = 5e-07
Identities = 90/411 (21%), Positives = 173/411 (42%), Gaps = 76/411 (18%)
Query: 40 LGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQH------KMEQR-QISLEGSVKG 92
L T E +R+NS+ + + +L+ QEN+H + QR QIS E VK
Sbjct: 538 LEKTIETLRENSE-----------RQIKILE--QENEHLNQTVSSLRQRSQISAEARVKD 584
Query: 93 IQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRR 152
I+ + L + TS+ +SK+ + R++ KE+ +R + LEN L +
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGER----AEELENELHHLEKE 640
Query: 153 NHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDE 212
N + +I + + + EL EN+ L++T L S +L
Sbjct: 641 NELL------QKKITNLKITCEKIEALEQENSELERENRKLKKT-----LDSFKNLTFQL 689
Query: 213 EALEDSAEEKVEES-----RAEKIKRSSLK----KVDSLKKAFSRQNIEKKMNKLGTKIV 263
E+LE + EE+ E +K +S+K ++++ + ++ ++K + L
Sbjct: 690 ESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
Query: 264 SVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREGES-----HAENETKSEDL 318
ER E + L +Q++ L KK+++ ES EN+T ++L
Sbjct: 750 KTERLEVSYQGLDIENQRLQ---------KTLENSNKKIQQLESELQDLEMENQTLQKNL 800
Query: 319 P----SSEQMPN-DQEEESFAEGHSEASLASALVEGE---IAEEAAEKATSRGSNSGMDS 370
SS+++ ++E +S + S+ +E E + ++A K T+ N+
Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860
Query: 371 NIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDGDPVQPAVLQV 421
N+ E+E+ L + + E L +E E+ + + V+ A + +
Sbjct: 861 NL--------EKENKTLSKEIGIYKESCVRL--KELEKENKELVKRATIDI 901
Score = 32.0 bits (71), Expect = 1.1
Identities = 65/283 (22%), Positives = 115/283 (40%), Gaps = 32/283 (11%)
Query: 69 LDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLE-KSRKV-----S 122
L V++N ++QRQ E V+ + +K++ + T +LL+ K R + +
Sbjct: 996 LKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1054
Query: 123 AHTRAVKERMDRQCAQVKRLENN-HAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVE 181
A +A K+ + Q Q++ NN AQ+L + + QE+N + K V +
Sbjct: 1055 ATLQAEKQALKTQLKQLETQNNNLQAQILALQR-QTVSLQEQNTTLQTQNAKLQVENSTL 1113
Query: 182 GKE---------ELPDENKSLEETLHTV-----DLSS-DDDLPHDEEALEDSAEEKVEES 226
+ +L + SLE +V DL S D L D E LE E + E
Sbjct: 1114 NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEY 1173
Query: 227 RAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGK 286
+ K +LK +++E + N+L + + E ++K L +K+
Sbjct: 1174 ESLISKHGTLKSAHK-NLEVEHRDLEDRYNQL---LKQKGQLEDLEKMLKVEQEKMLLEN 1229
Query: 287 SSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQE 329
+ V+ K GE+ N T S+ L +E + D +
Sbjct: 1230 KNHETVA----AEYKKLCGENDRLNHTYSQLLKETEVLQTDHK 1268
Score = 31.2 bits (69), Expect = 1.9
Identities = 55/236 (23%), Positives = 101/236 (42%), Gaps = 22/236 (9%)
Query: 184 EELPDENKSLEETLHTVDLSSDDD----LPHDEEALEDSAEEKVEESRAEKIKRSSLKKV 239
+ L DE ET+ ++LS + D LPH + + + R E + S++
Sbjct: 198 KRLIDERDEHSETI--IELSEERDGLHFLPHASSSAQSPCGSPGMK-RTESRQHLSVELA 254
Query: 240 DSLKKAFS-RQNIEKKMNKLGTKIVSVERRE-KIKKSLTSNHQKISSGKSSPFKVSPLTF 297
D+ K RQ +E+K +L +E+ E ++K+ N +S +S+ L
Sbjct: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA 314
Query: 298 GRKK-VREGESHAENETKSEDLPSSE-------QMPNDQ----EEESFAEGHSEASLASA 345
R+K VR + +E E L E ++ D E ++ E E + A +
Sbjct: 315 LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS 374
Query: 346 LVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYAL 401
E+ +E + ++ + M+ ++D +E+ EE++ LE AQK + S L
Sbjct: 375 DKLHELEKENLQ-LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHL 429
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 51.6 bits (122), Expect = 1e-06
Identities = 100/487 (20%), Positives = 188/487 (38%), Gaps = 89/487 (18%)
Query: 3 EDAAQAEKFQHP---GSDMRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVL 59
E A +A K Q+ S + +E S L +T+E +++ ++ + +
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETR-QKLNLS 1335
Query: 60 TLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSR 119
+ + +L +++QE Q + E+ + +LE V +Q+ L K T+ L E +
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 120 KVSAHTRAVKERMDRQCAQVKRLENNHAQLLRR--------NHFKVL------------- 158
K+ A+ +R++ + +LE +L + +H + +
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 159 IFQEENEIPA-------------------SVFVKQPVSGAVEGKEELPDENKSLEETLHT 199
+ EE I A ++ + + + A+E KEE +NK L +
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED 1515
Query: 200 VDLSSDDDL---PHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMN 256
+ +SS DD+ H+ E + + E++VEE R + L++++ +A + ++N
Sbjct: 1516 L-MSSKDDVGKNVHELEKSKRALEQQVEEMRTQ------LEELEDELQATEDAKLRLEVN 1568
Query: 257 KLGTKI-------VSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVR------ 303
K E+ E+ K+ L +++ + K L KK
Sbjct: 1569 MQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKD 1628
Query: 304 -EGESHAENETKSEDLPS----SEQMPNDQEE---------ESFAEG-HSEASLASALVE 348
E + A N+ + E + QM + Q E E FA+ SE L S +E
Sbjct: 1629 LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKS--LE 1686
Query: 349 GEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQA---QKVRYEGSYALTSEE 405
EI + E A+S + + D + DE S + + A +K R E A EE
Sbjct: 1687 AEILQLQEELASSERARRHAEQERD--ELADEITNSASGKSALLDEKRRLEARIAQLEEE 1744
Query: 406 AERSDGD 412
E +
Sbjct: 1745 LEEEQSN 1751
Score = 42.0 bits (97), Expect = 0.001
Identities = 65/305 (21%), Positives = 128/305 (41%), Gaps = 33/305 (10%)
Query: 128 VKERMDRQCAQVKRLENNHAQLLRRNHF-------KVLIFQEENEIPASVFVKQ------ 174
VKE+ + +++ +E H QLL + + +F E E+ A + K+
Sbjct: 864 VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEI 923
Query: 175 --PVSGAVEGKEE----LPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKV-EESR 227
+ VE +EE L +E K ++ H DL ++ L +E A + EKV E++
Sbjct: 924 LHDLESRVEEEEERNQILQNEKKKMQ--AHIQDL--EEQLDEEEGARQKLQLEKVTAEAK 979
Query: 228 AEKIKRSSLKKVDSLKKAFSRQNI-EKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGK 286
+K++ L D K + + E ++ + +++ E + K + + + + S
Sbjct: 980 IKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDL 1039
Query: 287 SSPFKVSPLTFGRKKVREGESHAENETKS-EDLPSSEQMPNDQEEESFAEGHSEASLASA 345
K T R+++ + + + ET +D + Q D+ + A+ E L A
Sbjct: 1040 EERLKKEEKT--RQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAK--KEEELQGA 1095
Query: 346 LVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEE 405
L G+ +E K + + + I + ED E E + +A+K + + S L + +
Sbjct: 1096 LARGD--DETLHKNNALKVVRELQAQI-AELQEDFESEKASRNKAEKQKRDLSEELEALK 1152
Query: 406 AERSD 410
E D
Sbjct: 1153 TELED 1157
Score = 42.0 bits (97), Expect = 0.001
Identities = 71/329 (21%), Positives = 153/329 (46%), Gaps = 49/329 (14%)
Query: 44 EEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKY 103
EE R N Q+ A ++ L++ D V +N H++E+ + +LE V+ ++ L +L
Sbjct: 1500 EEFERQNKQLRAD-----MEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE 1554
Query: 104 QASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEE 163
+T + +KL ++ + +A+K + +R Q + +N + L + L + E
Sbjct: 1555 LQATED--AKL-----RLEVNMQAMKAQFERD-LQTRDEQNEEKKRLLIKQVRELEAELE 1606
Query: 164 NEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLP--HDEEALEDSAEE 221
+E ++ + AV K+++ + K LE + + + D+ + +A +
Sbjct: 1607 DE-------RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR 1659
Query: 222 KVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVER----REKIKKSLTS 277
++EE+RA + + + K +S KK +++E ++ +L ++ S ER E+ + L
Sbjct: 1660 ELEEARASRDEIFAQSK-ESEKKL---KSLEAEILQLQEELASSERARRHAEQERDELAD 1715
Query: 278 NHQKISSGKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGH 337
+SGKS+ +K R A+ E + E+ S+ ++ ND+ ++ +
Sbjct: 1716 EITNSASGKSALLD--------EKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ-- 1765
Query: 338 SEASLASALVEGEIAEEAAEKATSRGSNS 366
V+ AE AAE++ ++ S++
Sbjct: 1766 ---------VDTLNAELAAERSAAQKSDN 1785
Score = 36.2 bits (82), Expect = 0.058
Identities = 74/369 (20%), Positives = 152/369 (41%), Gaps = 57/369 (15%)
Query: 35 SPSLNLGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQR----QISLEGSV 90
S + E+ RD S+ + T L+ ++ A QE + K EQ + +LE
Sbjct: 1129 SEKASRNKAEKQKRDLSE-ELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEET 1187
Query: 91 KGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQ----CAQVKRLENNH 146
K + + + + A+ +S+ LE++++ A+ K+ ++ +VK L+
Sbjct: 1188 KNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVK 1247
Query: 147 AQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDD 206
A+ H + + + E+ A V S + EL ++ L+ L V ++
Sbjct: 1248 AE---SEHKRKKLDAQVQELHAKV------SEGDRLRVELAEKASKLQNELDNVSTLLEE 1298
Query: 207 ----------DLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAF---------S 247
D E L+D+ E EE+R + S +++++ K + +
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 248 RQNIEKKM-----------NKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLT 296
R+N+EK++ K+ + ++E E+ KK L + + + S + L
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEAL----SQRLEEKALA 1414
Query: 297 FGRKKVREGESHAENETKSEDLPSSEQMPN--DQEEESFAEGHSEASLASA--LVEGEIA 352
+ + + + E + + DL Q+ + +++++ F + +E SA E + A
Sbjct: 1415 YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA 1474
Query: 353 E-EAAEKAT 360
E EA EK T
Sbjct: 1475 EAEAREKET 1483
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 50.1 bits (118), Expect = 4e-06
Identities = 78/412 (18%), Positives = 160/412 (38%), Gaps = 63/412 (15%)
Query: 3 EDAAQAEKFQHPGSDMRQEKPSSPSPMPSSTPSPSLNLGNT---EEA--IRDNSQVNAVT 57
E+ A E+ + + ++K S + T +N N+ EEA N+QV
Sbjct: 34 EEEAARERRRRARQERLRQKQEEES-LGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDD 92
Query: 58 VLTLLDKLVNMLDAVQENQHKMEQRQISLEGSV---------KGIQNDL----------- 97
L++L + Q+ + +RQ + ++ + +QND
Sbjct: 93 EAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEK 152
Query: 98 --TKLSKYQASTSNTVSKLLEKS--RKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRN 153
++ +Y+ + TV+K +K+ R + + KE+ + + + KR + N
Sbjct: 153 SESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS------IGEN 206
Query: 154 HFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEE 213
+V++ ++ E V +G + +E +E + + SD+ H++
Sbjct: 207 QVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER---------EQGSDEISHHEKM 257
Query: 214 ALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKK 273
ED + E +R E +R +K K A R IE + + ERRE ++
Sbjct: 258 EEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQE---RERREAEER 314
Query: 274 SLTSNHQKISSGKSSPFKVSPLTFGRKKVREGESHAENE---TKSEDLPSSEQMPNDQEE 330
+K ++ + R++++E E A E K E+ ++E+ +EE
Sbjct: 315 ERMREEEKRAAEE------------RQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEE 362
Query: 331 ESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEEE 382
E A + + A + ++ E+ K ++ ++ I VE + E
Sbjct: 363 EKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIE 414
Score = 42.0 bits (97), Expect = 0.001
Identities = 59/308 (19%), Positives = 114/308 (37%), Gaps = 27/308 (8%)
Query: 116 EKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLR-RNHFKVLIFQEENEIPASVFVKQ 174
E++R + A +ER R+ + +R+ + R K +E+ +K+
Sbjct: 291 ERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKE---EEKRAAEERQRIKE 347
Query: 175 PVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRS 234
A E ++ + +E K E ++ +E+ EEK + KIK
Sbjct: 348 EEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE 407
Query: 235 SLK-------------KVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQK 281
++ + D L+ A ++ E+K K+ K ++ + K +K
Sbjct: 408 KVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEK 467
Query: 282 ISSGKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEAS 341
I K +V +K E +S E + L + E +F+ AS
Sbjct: 468 IKKDKEPKEEVKSFMDRKKGFTEVKSQ-NGEFMTHKLKHT--------ENTFSRPGGRAS 518
Query: 342 LASALVEGEIAEEAAEKATSRGSNSGMDSNIDL-TIVEDEEEESVALEQAQKVRYEGSYA 400
+ + EG EA ++ G + + + + ++E ++ LE+ +K R E
Sbjct: 519 VDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKV 578
Query: 401 LTSEEAER 408
L EE R
Sbjct: 579 LEEEEQRR 586
Score = 39.3 bits (90), Expect = 0.007
Identities = 73/350 (20%), Positives = 127/350 (36%), Gaps = 53/350 (15%)
Query: 71 AVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKE 130
A QE + + + + + K + ++ + + + ++ E+ ++ + + +KE
Sbjct: 302 AAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKE 361
Query: 131 RMDRQCAQVKRL---ENNHAQLLRRNHFKVLIFQEENEIPASVFVK-QPVSGAVEGKEEL 186
R + +R E A++ + K L +E+ +K + V +EGK
Sbjct: 362 EEKRAAEERQRARAEEEEKAKVEEQKRNKQL--EEKKHAMQETKIKGEKVEQKIEGK--W 417
Query: 187 PDENKSLEETLHTVDLSSDDD------LPHDEEALEDSAEEKVEESRAEKIKRSSLKKVD 240
+E K+ E+ L T L + E+ ED K EE + EKIK+ K +
Sbjct: 418 VNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPK-E 476
Query: 241 SLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSL--TSNHQKISSGKSSPFKVSPLTFG 298
+K R K G V + E + L T N G++S
Sbjct: 477 EVKSFMDR--------KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASV--------- 519
Query: 299 RKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEK 358
K EG E + E+L +E E + EA+L EE +K
Sbjct: 520 DTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALE--------LEELKKK 571
Query: 359 ATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAER 408
R ++E+EE+ E +K+R E EE ER
Sbjct: 572 REERRK-----------VLEEEEQRRKQEEADRKLREEEEKRRLKEEIER 610
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 49.7 bits (117), Expect = 5e-06
Identities = 68/367 (18%), Positives = 147/367 (40%), Gaps = 41/367 (11%)
Query: 70 DAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVK 129
D+++E + + + +I++ S ++ + + + S + + SRK H R +
Sbjct: 12 DSLEEGELRDHRMEITIRNSPYRREDSME--DRGEEDDSLAIKPPQQMSRKEKVHHRKDE 69
Query: 130 ERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDE 189
+R +++ A+VK E H + R+ H +EE + + +Q + +E +
Sbjct: 70 KRKEKKHARVKEKEREHER--RKRH------REEQDKARREWERQ------KRREMAREH 115
Query: 190 NKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQ 249
++ + L ++ + + E+ E +++ E E+ K ++ S R+
Sbjct: 116 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 175
Query: 250 NIEKKMN----------------KLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVS 293
+ K+ +LG V+ + ++ L S+ Q IS + K S
Sbjct: 176 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER---KTS 232
Query: 294 PLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAE 353
+ G E E + E+ S +++EEE E E S + AE
Sbjct: 233 SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE 292
Query: 354 EAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDGD- 412
E +E+ S ++++ + + +S E+A++ EG T + + ++GD
Sbjct: 293 EVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG----TPQSSALTEGDY 348
Query: 413 -PVQPAV 418
P PA+
Sbjct: 349 VPDSPAL 355
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 49.3 bits (116), Expect = 7e-06
Identities = 73/359 (20%), Positives = 144/359 (40%), Gaps = 47/359 (13%)
Query: 62 LDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKV 121
L++ M + + +E + SL+ + ++ LTK+ K + +T N V L E+
Sbjct: 930 LEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEE---- 985
Query: 122 SAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVE 181
A++E + + + K L+ H Q L + +V EE+++ + + + +
Sbjct: 986 ---MTALEENISKLTKEKKSLQEAHQQTL--DDLQV----EEDKVNGLIKINAKLEQQTD 1036
Query: 182 GKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDS 241
E ++ K L L + DL +E++ D +K + EK+K+ +
Sbjct: 1037 DLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDK--QQIEEKLKKKEFELSQL 1094
Query: 242 LKKAFSRQ----NIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTF 297
K Q +KK+ +L +I +E + + +L + KI +S +
Sbjct: 1095 QAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRA---KIEKQRSDLARELEEIS 1151
Query: 298 GRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASL----ASALVE----- 348
R + G + A+ E + ++M D EE + + A+L A ++ E
Sbjct: 1152 ERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQI 1211
Query: 349 --------------GEIAEEAAEKATSRGSNSGMDSNIDLT--IVEDEEEESVALEQAQ 391
E+ E + A++ + S SNI+ T VED+ E A ++ Q
Sbjct: 1212 DNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQ 1270
Score = 43.9 bits (102), Expect = 3e-04
Identities = 75/381 (19%), Positives = 155/381 (40%), Gaps = 44/381 (11%)
Query: 64 KLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSA 123
+L +D +Q + K+E+ + L+ + + +++ LSK +++ T + ++ ++ A
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKA 1265
Query: 124 HTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEG- 182
+ + Q RL+ + +L R + ++E+ I KQ ++ +E
Sbjct: 1266 KDEQQTQLIHDLNMQKARLQTQNGELSHR------VEEKESLISQLTKSKQALTQQLEEL 1319
Query: 183 KEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRA------------EK 230
K ++ +E K+ H + SS D E E+ E K E RA K
Sbjct: 1320 KRQMEEETKAKNAMAHALQ-SSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTK 1378
Query: 231 IKRSSLKKVDSLKKAFSR-----QNIEKKMNKLGTKIVSVERR--------EKIKKSLTS 277
+ ++++ + L++A + Q E+ +K S+E+ E + + L
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLER 1438
Query: 278 NHQKISS-GKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSE--QMPN------DQ 328
+H ++ K L ++K+ E ++ E K S+E +M N DQ
Sbjct: 1439 SHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQ 1498
Query: 329 EEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMD-SNIDLTIVEDEEEESVAL 387
E E + S L E +IAE + + ++ DL + +E E S+
Sbjct: 1499 LETLRRENKNLQEEISDLTE-QIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH 1557
Query: 388 EQAQKVRYEGSYALTSEEAER 408
E+++ +R + + E +R
Sbjct: 1558 EESKILRVQLELSQVKSELDR 1578
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 48.1 bits (113), Expect = 1e-05
Identities = 68/367 (18%), Positives = 146/367 (39%), Gaps = 41/367 (11%)
Query: 70 DAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVK 129
D+++E + + +I++ S ++ + + + S + + SRK H R +
Sbjct: 46 DSLEEGELRDHCMEITIRNSPYRREDSME--DRGEEDDSLAIKPPQQMSRKEKVHHRKDE 103
Query: 130 ERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDE 189
+R +++ A+VK E H + R+ H +EE + + +Q + +E +
Sbjct: 104 KRKEKKHARVKEKEREHER--RKRH------REEQDKARREWERQ------KRREMAREH 149
Query: 190 NKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQ 249
++ + L ++ + + E+ E +++ E E+ K ++ S R+
Sbjct: 150 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 209
Query: 250 NIEKKMN----------------KLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVS 293
+ K+ +LG V+ + ++ L S+ Q IS + K S
Sbjct: 210 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER---KTS 266
Query: 294 PLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAE 353
+ G E E + E+ S +++EEE E E S + AE
Sbjct: 267 SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE 326
Query: 354 EAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDGD- 412
E +E+ S ++++ + + +S E+A++ EG T + + ++GD
Sbjct: 327 EVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG----TPQSSALTEGDY 382
Query: 413 -PVQPAV 418
P PA+
Sbjct: 383 VPDSPAL 389
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 47.8 bits (112), Expect = 2e-05
Identities = 75/387 (19%), Positives = 164/387 (42%), Gaps = 50/387 (12%)
Query: 44 EEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKY 103
EE R N + A ++ LV+ D V +N H++E+ + +LE ++ ++ L +L
Sbjct: 1500 EELERTNKMLKAE-----MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 104 QASTSNTVSKLLEKSRKVSAHTRAVKERMDRQC-AQVKRLENNHAQLLRRNH-FKVLIFQ 161
+T + +L + +A+K + +R A+ ++ E QL R+ H ++ +
Sbjct: 1555 LQATEDAKLRL-------EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 162 EENEIPASVFVKQPVSG-----------AVEGKEELPDENKSLEETLHTVDLSSDDDLPH 210
E + + K+ + G A++G+EE + + L+ + +D
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1667
Query: 211 DEE--ALEDSAEEKVEESRAEKI-------------KRSSLKK---VDSLKKAFSRQN-I 251
+E A E+K + A+ + K++ L+K + L + S +N +
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1727
Query: 252 EKKMNKLGTKIVSVERR-EKIKKSLTSNHQKISSGKSSPFKVS-PLTFGRKKVREGESHA 309
+ + +L +I +E E+ + ++ + ++ ++S L R ++ ES
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1787
Query: 310 EN-ETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGM 368
+ E ++++L S + F + A +E ++ +EA EK + S
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847
Query: 369 DSNIDLTIVEDEEEESVA---LEQAQK 392
D + +++ E+E +A EQA+K
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEK 1874
Score = 44.3 bits (103), Expect = 2e-04
Identities = 65/329 (19%), Positives = 131/329 (39%), Gaps = 47/329 (14%)
Query: 111 VSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASV 170
V++ E+ + + KER + ++K LE H+QL + Q E E+ A
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE- 905
Query: 171 FVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALED---------SAEE 221
A E + L + + LEE LH ++ +++ ++ + EE
Sbjct: 906 --------AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 222 KVEESRAEKIK--------RSSLKKVD---------SLKKAFSRQNIEKKMNKLGTKIVS 264
++EE A + K + +KK++ + K + R+ +E++++ L T +
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 265 VERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQM 324
E + K L + H+ + S K +K R+ + + + + EQ+
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLK------KEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 325 PNDQ---EEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEE 381
+ Q E E L +AL + +E A+K + ++ +I + ED +
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHIS-DLQEDLD 1128
Query: 382 EESVALEQAQKVRYEGSYALTSEEAERSD 410
E A +A+K + + L + + E D
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELED 1157
Score = 44.3 bits (103), Expect = 2e-04
Identities = 99/483 (20%), Positives = 188/483 (38%), Gaps = 82/483 (16%)
Query: 18 MRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQH 77
M E + S S L +T+E +++ ++ + V T L +L +++Q+
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKLRQLEEERNSLQDQLD 1353
Query: 78 KMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCA 137
+ + + +LE + + L+ K ++TV L E ++ + ++ + + A
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1413
Query: 138 QVKRLE-----------------NNHAQLL-----RRNHFKVLIFQEEN----------- 164
+LE +N QL+ ++ F L+ +E+N
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 165 -------EIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALED 217
+ ++ + + + A+E KEEL NK L+ + + +SS DD+ + LE
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL-VSSKDDVGKNVHELEK 1532
Query: 218 SAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTK-------IVSVERREK 270
S ++ E++ E++K + L++++ +A + ++N K E+ E+
Sbjct: 1533 S--KRALETQMEEMK-TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589
Query: 271 IKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREG-----ESHAENETKSEDLPSSEQMP 325
++ L + + K L KK EG E A++ K + + +Q+
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE-EAIKQLR 1648
Query: 326 NDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVE------D 379
Q + + E + AS A+E +KA S ++ M DL E D
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL-MQLQEDLAAAERARKQAD 1707
Query: 380 EEEESVALE-----------QAQKVRYEGSYALTSEEAERSDG------DPVQPAVLQVH 422
E+E +A E Q +K R E A EE E G D V+ A Q
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 423 QTS 425
Q S
Sbjct: 1768 QLS 1770
Score = 38.9 bits (89), Expect = 0.009
Identities = 50/255 (19%), Positives = 108/255 (42%), Gaps = 43/255 (16%)
Query: 44 EEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDL------ 97
EEA R Q+ VT + KL + + + + +K+ + + LE + + +L
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 98 ----TKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQV-KRLENNHAQLLRR 152
TKL S + + L+K K +K +++ + +++ + AQ+
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE- 1080
Query: 153 NHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDE 212
K+ + ++E E+ A++ +E+ +N +L++ H
Sbjct: 1081 --LKMQLAKKEEELQAAL---------ARLDDEIAQKNNALKKIRELEG--------HIS 1121
Query: 213 EALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREK-- 270
+ ED E+ ++AEK KR +++++LK +E ++ T+ +RE+
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALK-----TELEDTLDSTATQQELRAKREQEV 1176
Query: 271 --IKKSL---TSNHQ 280
+KK+L T +H+
Sbjct: 1177 TVLKKALDEETRSHE 1191
Score = 31.2 bits (69), Expect = 1.9
Identities = 71/345 (20%), Positives = 137/345 (39%), Gaps = 41/345 (11%)
Query: 69 LDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAV 128
LD+ + ++K E+++ L ++ ++ T+L ST+ ++ ++V+ +A+
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALK---TELEDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 129 KERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPD 188
E AQV+ + HAQ + L Q E K+ + + K+ L
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEE-----LTEQLEQ-------FKRAKANLDKNKQTLEK 1231
Query: 189 ENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEE-SRAEKIKRSSLKKVDSLKKAFS 247
EN L L + + ++ H ++ LE +E + S E+ + KV L+
Sbjct: 1232 ENADLAGELRVLG-QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 248 R-----QNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKV 302
E K KL + S+ + + + L + S+ K+ L R +
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST--KLRQLEEERNSL 1348
Query: 303 REGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGE---------IAE 353
++ + E E K ++L N Q +S + AS AL EG+ + +
Sbjct: 1349 QD-QLDEEMEAK-QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 354 EAAEKATS-----RGSNSGMDSNIDLTIVEDEEEESVA-LEQAQK 392
+ EKA + + N DL + D + + V+ LE+ Q+
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 47.8 bits (112), Expect = 2e-05
Identities = 75/387 (19%), Positives = 164/387 (42%), Gaps = 50/387 (12%)
Query: 44 EEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKY 103
EE R N + A ++ LV+ D V +N H++E+ + +LE ++ ++ L +L
Sbjct: 1507 EELERTNKMLKAE-----MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 104 QASTSNTVSKLLEKSRKVSAHTRAVKERMDRQC-AQVKRLENNHAQLLRRNH-FKVLIFQ 161
+T + +L + +A+K + +R A+ ++ E QL R+ H ++ +
Sbjct: 1562 LQATEDAKLRL-------EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 162 EENEIPASVFVKQPVSG-----------AVEGKEELPDENKSLEETLHTVDLSSDDDLPH 210
E + + K+ + G A++G+EE + + L+ + +D
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1674
Query: 211 DEE--ALEDSAEEKVEESRAEKI-------------KRSSLKK---VDSLKKAFSRQN-I 251
+E A E+K + A+ + K++ L+K + L + S +N +
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1734
Query: 252 EKKMNKLGTKIVSVERR-EKIKKSLTSNHQKISSGKSSPFKVS-PLTFGRKKVREGESHA 309
+ + +L +I +E E+ + ++ + ++ ++S L R ++ ES
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794
Query: 310 EN-ETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGM 368
+ E ++++L S + F + A +E ++ +EA EK + S
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Query: 369 DSNIDLTIVEDEEEESVA---LEQAQK 392
D + +++ E+E +A EQA+K
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEK 1881
Score = 44.3 bits (103), Expect = 2e-04
Identities = 65/329 (19%), Positives = 131/329 (39%), Gaps = 47/329 (14%)
Query: 111 VSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASV 170
V++ E+ + + KER + ++K LE H+QL + Q E E+ A
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE- 912
Query: 171 FVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALED---------SAEE 221
A E + L + + LEE LH ++ +++ ++ + EE
Sbjct: 913 --------AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 222 KVEESRAEKIK--------RSSLKKVD---------SLKKAFSRQNIEKKMNKLGTKIVS 264
++EE A + K + +KK++ + K + R+ +E++++ L T +
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 265 VERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQM 324
E + K L + H+ + S K +K R+ + + + + EQ+
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLK------KEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 325 PNDQ---EEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEE 381
+ Q E E L +AL + +E A+K + ++ +I + ED +
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHIS-DLQEDLD 1135
Query: 382 EESVALEQAQKVRYEGSYALTSEEAERSD 410
E A +A+K + + L + + E D
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELED 1164
Score = 44.3 bits (103), Expect = 2e-04
Identities = 99/483 (20%), Positives = 188/483 (38%), Gaps = 82/483 (16%)
Query: 18 MRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQH 77
M E + S S L +T+E +++ ++ + V T L +L +++Q+
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKLRQLEEERNSLQDQLD 1360
Query: 78 KMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCA 137
+ + + +LE + + L+ K ++TV L E ++ + ++ + + A
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1420
Query: 138 QVKRLE-----------------NNHAQLL-----RRNHFKVLIFQEEN----------- 164
+LE +N QL+ ++ F L+ +E+N
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 165 -------EIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALED 217
+ ++ + + + A+E KEEL NK L+ + + +SS DD+ + LE
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL-VSSKDDVGKNVHELEK 1539
Query: 218 SAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTK-------IVSVERREK 270
S ++ E++ E++K + L++++ +A + ++N K E+ E+
Sbjct: 1540 S--KRALETQMEEMK-TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596
Query: 271 IKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREG-----ESHAENETKSEDLPSSEQMP 325
++ L + + K L KK EG E A++ K + + +Q+
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE-EAIKQLR 1655
Query: 326 NDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVE------D 379
Q + + E + AS A+E +KA S ++ M DL E D
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL-MQLQEDLAAAERARKQAD 1714
Query: 380 EEEESVALE-----------QAQKVRYEGSYALTSEEAERSDG------DPVQPAVLQVH 422
E+E +A E Q +K R E A EE E G D V+ A Q
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 423 QTS 425
Q S
Sbjct: 1775 QLS 1777
Score = 38.9 bits (89), Expect = 0.009
Identities = 50/255 (19%), Positives = 108/255 (42%), Gaps = 43/255 (16%)
Query: 44 EEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDL------ 97
EEA R Q+ VT + KL + + + + +K+ + + LE + + +L
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 98 ----TKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQV-KRLENNHAQLLRR 152
TKL S + + L+K K +K +++ + +++ + AQ+
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE- 1087
Query: 153 NHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDE 212
K+ + ++E E+ A++ +E+ +N +L++ H
Sbjct: 1088 --LKMQLAKKEEELQAAL---------ARLDDEIAQKNNALKKIRELEG--------HIS 1128
Query: 213 EALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREK-- 270
+ ED E+ ++AEK KR +++++LK +E ++ T+ +RE+
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALK-----TELEDTLDSTATQQELRAKREQEV 1183
Query: 271 --IKKSL---TSNHQ 280
+KK+L T +H+
Sbjct: 1184 TVLKKALDEETRSHE 1198
Score = 31.2 bits (69), Expect = 1.9
Identities = 71/345 (20%), Positives = 137/345 (39%), Gaps = 41/345 (11%)
Query: 69 LDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAV 128
LD+ + ++K E+++ L ++ ++ T+L ST+ ++ ++V+ +A+
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALK---TELEDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 129 KERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPD 188
E AQV+ + HAQ + L Q E K+ + + K+ L
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEE-----LTEQLEQ-------FKRAKANLDKNKQTLEK 1238
Query: 189 ENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEE-SRAEKIKRSSLKKVDSLKKAFS 247
EN L L + + ++ H ++ LE +E + S E+ + KV L+
Sbjct: 1239 ENADLAGELRVLG-QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 248 R-----QNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKV 302
E K KL + S+ + + + L + S+ K+ L R +
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST--KLRQLEEERNSL 1355
Query: 303 REGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGE---------IAE 353
++ + E E K ++L N Q +S + AS AL EG+ + +
Sbjct: 1356 QD-QLDEEMEAK-QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 354 EAAEKATS-----RGSNSGMDSNIDLTIVEDEEEESVA-LEQAQK 392
+ EKA + + N DL + D + + V+ LE+ Q+
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 47.8 bits (112), Expect = 2e-05
Identities = 75/387 (19%), Positives = 164/387 (42%), Gaps = 50/387 (12%)
Query: 44 EEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKY 103
EE R N + A ++ LV+ D V +N H++E+ + +LE ++ ++ L +L
Sbjct: 1507 EELERTNKMLKAE-----MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 104 QASTSNTVSKLLEKSRKVSAHTRAVKERMDRQC-AQVKRLENNHAQLLRRNH-FKVLIFQ 161
+T + +L + +A+K + +R A+ ++ E QL R+ H ++ +
Sbjct: 1562 LQATEDAKLRL-------EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 162 EENEIPASVFVKQPVSG-----------AVEGKEELPDENKSLEETLHTVDLSSDDDLPH 210
E + + K+ + G A++G+EE + + L+ + +D
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1674
Query: 211 DEE--ALEDSAEEKVEESRAEKI-------------KRSSLKK---VDSLKKAFSRQN-I 251
+E A E+K + A+ + K++ L+K + L + S +N +
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1734
Query: 252 EKKMNKLGTKIVSVERR-EKIKKSLTSNHQKISSGKSSPFKVS-PLTFGRKKVREGESHA 309
+ + +L +I +E E+ + ++ + ++ ++S L R ++ ES
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1794
Query: 310 EN-ETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGM 368
+ E ++++L S + F + A +E ++ +EA EK + S
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854
Query: 369 DSNIDLTIVEDEEEESVA---LEQAQK 392
D + +++ E+E +A EQA+K
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEK 1881
Score = 44.3 bits (103), Expect = 2e-04
Identities = 65/329 (19%), Positives = 131/329 (39%), Gaps = 47/329 (14%)
Query: 111 VSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASV 170
V++ E+ + + KER + ++K LE H+QL + Q E E+ A
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE- 912
Query: 171 FVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALED---------SAEE 221
A E + L + + LEE LH ++ +++ ++ + EE
Sbjct: 913 --------AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 222 KVEESRAEKIK--------RSSLKKVD---------SLKKAFSRQNIEKKMNKLGTKIVS 264
++EE A + K + +KK++ + K + R+ +E++++ L T +
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 265 VERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQM 324
E + K L + H+ + S K +K R+ + + + + EQ+
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLK------KEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 325 PNDQ---EEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEE 381
+ Q E E L +AL + +E A+K + ++ +I + ED +
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHIS-DLQEDLD 1135
Query: 382 EESVALEQAQKVRYEGSYALTSEEAERSD 410
E A +A+K + + L + + E D
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELED 1164
Score = 44.3 bits (103), Expect = 2e-04
Identities = 99/483 (20%), Positives = 188/483 (38%), Gaps = 82/483 (16%)
Query: 18 MRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQH 77
M E + S S L +T+E +++ ++ + V T L +L +++Q+
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKLRQLEEERNSLQDQLD 1360
Query: 78 KMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCA 137
+ + + +LE + + L+ K ++TV L E ++ + ++ + + A
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1420
Query: 138 QVKRLE-----------------NNHAQLL-----RRNHFKVLIFQEEN----------- 164
+LE +N QL+ ++ F L+ +E+N
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 165 -------EIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALED 217
+ ++ + + + A+E KEEL NK L+ + + +SS DD+ + LE
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL-VSSKDDVGKNVHELEK 1539
Query: 218 SAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTK-------IVSVERREK 270
S ++ E++ E++K + L++++ +A + ++N K E+ E+
Sbjct: 1540 S--KRALETQMEEMK-TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596
Query: 271 IKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREG-----ESHAENETKSEDLPSSEQMP 325
++ L + + K L KK EG E A++ K + + +Q+
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE-EAIKQLR 1655
Query: 326 NDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVE------D 379
Q + + E + AS A+E +KA S ++ M DL E D
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL-MQLQEDLAAAERARKQAD 1714
Query: 380 EEEESVALE-----------QAQKVRYEGSYALTSEEAERSDG------DPVQPAVLQVH 422
E+E +A E Q +K R E A EE E G D V+ A Q
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 423 QTS 425
Q S
Sbjct: 1775 QLS 1777
Score = 38.9 bits (89), Expect = 0.009
Identities = 50/255 (19%), Positives = 108/255 (42%), Gaps = 43/255 (16%)
Query: 44 EEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDL------ 97
EEA R Q+ VT + KL + + + + +K+ + + LE + + +L
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 98 ----TKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQV-KRLENNHAQLLRR 152
TKL S + + L+K K +K +++ + +++ + AQ+
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE- 1087
Query: 153 NHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDE 212
K+ + ++E E+ A++ +E+ +N +L++ H
Sbjct: 1088 --LKMQLAKKEEELQAAL---------ARLDDEIAQKNNALKKIRELEG--------HIS 1128
Query: 213 EALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREK-- 270
+ ED E+ ++AEK KR +++++LK +E ++ T+ +RE+
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALK-----TELEDTLDSTATQQELRAKREQEV 1183
Query: 271 --IKKSL---TSNHQ 280
+KK+L T +H+
Sbjct: 1184 TVLKKALDEETRSHE 1198
Score = 31.2 bits (69), Expect = 1.9
Identities = 71/345 (20%), Positives = 137/345 (39%), Gaps = 41/345 (11%)
Query: 69 LDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAV 128
LD+ + ++K E+++ L ++ ++ T+L ST+ ++ ++V+ +A+
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALK---TELEDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 129 KERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPD 188
E AQV+ + HAQ + L Q E K+ + + K+ L
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEE-----LTEQLEQ-------FKRAKANLDKNKQTLEK 1238
Query: 189 ENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEE-SRAEKIKRSSLKKVDSLKKAFS 247
EN L L + + ++ H ++ LE +E + S E+ + KV L+
Sbjct: 1239 ENADLAGELRVLG-QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 248 R-----QNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKV 302
E K KL + S+ + + + L + S+ K+ L R +
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST--KLRQLEEERNSL 1355
Query: 303 REGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGE---------IAE 353
++ + E E K ++L N Q +S + AS AL EG+ + +
Sbjct: 1356 QD-QLDEEMEAK-QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 354 EAAEKATS-----RGSNSGMDSNIDLTIVEDEEEESVA-LEQAQK 392
+ EKA + + N DL + D + + V+ LE+ Q+
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 47.8 bits (112), Expect = 2e-05
Identities = 75/387 (19%), Positives = 164/387 (42%), Gaps = 50/387 (12%)
Query: 44 EEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKY 103
EE R N + A ++ LV+ D V +N H++E+ + +LE ++ ++ L +L
Sbjct: 1500 EELERTNKMLKAE-----MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 104 QASTSNTVSKLLEKSRKVSAHTRAVKERMDRQC-AQVKRLENNHAQLLRRNH-FKVLIFQ 161
+T + +L + +A+K + +R A+ ++ E QL R+ H ++ +
Sbjct: 1555 LQATEDAKLRL-------EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 162 EENEIPASVFVKQPVSG-----------AVEGKEELPDENKSLEETLHTVDLSSDDDLPH 210
E + + K+ + G A++G+EE + + L+ + +D
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1667
Query: 211 DEE--ALEDSAEEKVEESRAEKI-------------KRSSLKK---VDSLKKAFSRQN-I 251
+E A E+K + A+ + K++ L+K + L + S +N +
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1727
Query: 252 EKKMNKLGTKIVSVERR-EKIKKSLTSNHQKISSGKSSPFKVS-PLTFGRKKVREGESHA 309
+ + +L +I +E E+ + ++ + ++ ++S L R ++ ES
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESAR 1787
Query: 310 EN-ETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGM 368
+ E ++++L S + F + A +E ++ +EA EK + S
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847
Query: 369 DSNIDLTIVEDEEEESVA---LEQAQK 392
D + +++ E+E +A EQA+K
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEK 1874
Score = 44.3 bits (103), Expect = 2e-04
Identities = 65/329 (19%), Positives = 131/329 (39%), Gaps = 47/329 (14%)
Query: 111 VSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASV 170
V++ E+ + + KER + ++K LE H+QL + Q E E+ A
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE- 905
Query: 171 FVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALED---------SAEE 221
A E + L + + LEE LH ++ +++ ++ + EE
Sbjct: 906 --------AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 222 KVEESRAEKIK--------RSSLKKVD---------SLKKAFSRQNIEKKMNKLGTKIVS 264
++EE A + K + +KK++ + K + R+ +E++++ L T +
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 265 VERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQM 324
E + K L + H+ + S K +K R+ + + + + EQ+
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLK------KEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 325 PNDQ---EEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEE 381
+ Q E E L +AL + +E A+K + ++ +I + ED +
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAAL--ARLDDEIAQKNNALKKIRELEGHIS-DLQEDLD 1128
Query: 382 EESVALEQAQKVRYEGSYALTSEEAERSD 410
E A +A+K + + L + + E D
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELED 1157
Score = 44.3 bits (103), Expect = 2e-04
Identities = 99/483 (20%), Positives = 188/483 (38%), Gaps = 82/483 (16%)
Query: 18 MRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQH 77
M E + S S L +T+E +++ ++ + V T L +L +++Q+
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-QKLNVSTKLRQLEEERNSLQDQLD 1353
Query: 78 KMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCA 137
+ + + +LE + + L+ K ++TV L E ++ + ++ + + A
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1413
Query: 138 QVKRLE-----------------NNHAQLL-----RRNHFKVLIFQEEN----------- 164
+LE +N QL+ ++ F L+ +E+N
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 165 -------EIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALED 217
+ ++ + + + A+E KEEL NK L+ + + +SS DD+ + LE
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL-VSSKDDVGKNVHELEK 1532
Query: 218 SAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTK-------IVSVERREK 270
S ++ E++ E++K + L++++ +A + ++N K E+ E+
Sbjct: 1533 S--KRALETQMEEMK-TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589
Query: 271 IKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREG-----ESHAENETKSEDLPSSEQMP 325
++ L + + K L KK EG E A++ K + + +Q+
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE-EAIKQLR 1648
Query: 326 NDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVE------D 379
Q + + E + AS A+E +KA S ++ M DL E D
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL-MQLQEDLAAAERARKQAD 1707
Query: 380 EEEESVALE-----------QAQKVRYEGSYALTSEEAERSDG------DPVQPAVLQVH 422
E+E +A E Q +K R E A EE E G D V+ A Q
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 423 QTS 425
Q S
Sbjct: 1768 QLS 1770
Score = 38.9 bits (89), Expect = 0.009
Identities = 50/255 (19%), Positives = 108/255 (42%), Gaps = 43/255 (16%)
Query: 44 EEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDL------ 97
EEA R Q+ VT + KL + + + + +K+ + + LE + + +L
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 98 ----TKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQV-KRLENNHAQLLRR 152
TKL S + + L+K K +K +++ + +++ + AQ+
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE- 1080
Query: 153 NHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDE 212
K+ + ++E E+ A++ +E+ +N +L++ H
Sbjct: 1081 --LKMQLAKKEEELQAAL---------ARLDDEIAQKNNALKKIRELEG--------HIS 1121
Query: 213 EALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREK-- 270
+ ED E+ ++AEK KR +++++LK +E ++ T+ +RE+
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALK-----TELEDTLDSTATQQELRAKREQEV 1176
Query: 271 --IKKSL---TSNHQ 280
+KK+L T +H+
Sbjct: 1177 TVLKKALDEETRSHE 1191
Score = 31.2 bits (69), Expect = 1.9
Identities = 71/345 (20%), Positives = 137/345 (39%), Gaps = 41/345 (11%)
Query: 69 LDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAV 128
LD+ + ++K E+++ L ++ ++ T+L ST+ ++ ++V+ +A+
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALK---TELEDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 129 KERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPD 188
E AQV+ + HAQ + L Q E K+ + + K+ L
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEE-----LTEQLEQ-------FKRAKANLDKNKQTLEK 1231
Query: 189 ENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEE-SRAEKIKRSSLKKVDSLKKAFS 247
EN L L + + ++ H ++ LE +E + S E+ + KV L+
Sbjct: 1232 ENADLAGELRVLG-QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 248 R-----QNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKV 302
E K KL + S+ + + + L + S+ K+ L R +
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST--KLRQLEEERNSL 1348
Query: 303 REGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGE---------IAE 353
++ + E E K ++L N Q +S + AS AL EG+ + +
Sbjct: 1349 QD-QLDEEMEAK-QNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 354 EAAEKATS-----RGSNSGMDSNIDLTIVEDEEEESVA-LEQAQK 392
+ EKA + + N DL + D + + V+ LE+ Q+
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 47.4 bits (111), Expect = 3e-05
Identities = 48/240 (20%), Positives = 104/240 (43%), Gaps = 30/240 (12%)
Query: 62 LDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQAST-------SNTVSKL 114
L+K++ L + ++ K+ Q +I + + + +LS Q+ S S+L
Sbjct: 2073 LNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSEL 2132
Query: 115 LEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFV-- 172
+ +K++ R + +M R + +++ ++L R++ +L +EE I +
Sbjct: 2133 TKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPF 2192
Query: 173 -----------------KQPVSGAV---EGKEELPDENKSLEETLHTVD-LSSDDDLPHD 211
K+ S V E +E +E +SL + L + LSS+++ +
Sbjct: 2193 LKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEERE 2252
Query: 212 EEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKI 271
EE + E + EE ++ + K+V+ ++ ++ EKK ++ K E +E+I
Sbjct: 2253 EEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEI 2312
>gi|38569484 kinesin family member 21A [Homo sapiens]
Length = 1661
Score = 46.2 bits (108), Expect = 6e-05
Identities = 47/222 (21%), Positives = 95/222 (42%), Gaps = 26/222 (11%)
Query: 59 LTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKS 118
L ++K + L A Q+ ++ + Q E +K +Q D+ ++ K T +L+++
Sbjct: 712 LQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKK-------TKVRLMKQM 764
Query: 119 RKVSAHTRAVKERMDRQCAQVKRLENNHAQLLR-----RNHFKVLIFQEENEIPASVFVK 173
++ R + R +R+ AQ+K+ + LR + + +V++ ++ E+ A
Sbjct: 765 KEEQEKARLTESRRNREIAQLKKDQRKRDHQLRLLEAQKRNQEVVLRRKTEEVTALRRQV 824
Query: 174 QPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKR 233
+P+S V GK T LSS D D + + E + A++ R
Sbjct: 825 RPMSDKVAGKV--------------TRKLSSSDAPAQDTGSSAAAVETDASRTGAQQKMR 870
Query: 234 SSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSL 275
+ +V +L + N +K K T V + + ++K L
Sbjct: 871 IPVARVQALPTPATNGNRKKYQRKGLTGRVFISKTARMKWQL 912
Score = 30.4 bits (67), Expect = 3.2
Identities = 18/91 (19%), Positives = 47/91 (51%), Gaps = 3/91 (3%)
Query: 61 LLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRK 120
L+D+L N +Q + + E++ + L+ ++ Q + ++ + S + EK++K
Sbjct: 647 LIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSE---EKAKK 703
Query: 121 VSAHTRAVKERMDRQCAQVKRLENNHAQLLR 151
V + + M+++ +++ + HA+LL+
Sbjct: 704 VRSEYEKKLQAMNKELQRLQAAQKEHARLLK 734
>gi|38045919 huntingtin interacting protein 1 [Homo sapiens]
Length = 1037
Score = 46.2 bits (108), Expect = 6e-05
Identities = 61/281 (21%), Positives = 113/281 (40%), Gaps = 30/281 (10%)
Query: 49 DNSQVNAVTVLTLLDKLVNMLDA-VQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQAST 107
+N + + V+ L V+ L+A + E QH +Q E ++ +L +L + + T
Sbjct: 392 ENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEF----LRAELDELRRQREDT 447
Query: 108 SNTVSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIP 167
L E RK A+ ++R + + L NHA LLR+N
Sbjct: 448 EKAQRSLSEIERKAQAN----EQRYSKLKEKYSELVQNHADLLRKN-------------- 489
Query: 168 ASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESR 227
V + VS A + + +L E K LE++L + E LE +E R
Sbjct: 490 --AEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQR 547
Query: 228 AEKIKRSSLKKVDSLKKAFSRQ--NIEKKMNKLGTKIVSVERR-EKIKKSLTSNHQKISS 284
++ + SL+ + ++ + +EK+ + L + E ++K L K++S
Sbjct: 548 ELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS 607
Query: 285 GKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQMP 325
+ S +++ RK + G A + + L E+ P
Sbjct: 608 TEESMCQLA--KDQRKMLLVGSRKAAEQVIQDALNQLEEPP 646
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 45.8 bits (107), Expect = 7e-05
Identities = 90/461 (19%), Positives = 172/461 (37%), Gaps = 63/461 (13%)
Query: 4 DAAQAEKFQHPGSDMRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLTLLD 63
D+++ EK G D + K S SS + T + + T++ L D
Sbjct: 810 DSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDT-TIMELRD 868
Query: 64 KL------------VNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTV 111
+L V+ L +++ +E R+++ E K K Q S+
Sbjct: 869 RLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVA-ETKEKSKHLKTKTCKKVQDGLSDIA 927
Query: 112 SKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVF 171
K L+K + S T ++ ++ + K+ ++ + KV+ +++ E +
Sbjct: 928 EKFLKKDQ--SDETSEDDKKQSKKGTEEKKKPSDFKK-------KVIKMEQQYESSSDGT 978
Query: 172 VKQPV--------SGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALE-----DS 218
K P G + K D K ++ D+ + E++ DS
Sbjct: 979 EKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDS 1038
Query: 219 AEEKV--------EESRAEKIKRSSLKKVDSLKKAFSRQNI-EKKMNKLGTKIVSVERRE 269
+E+K E+ R + + +SS K+ D + ++ E N ++ +E RE
Sbjct: 1039 SEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRE 1098
Query: 270 KIKKSLTSNHQKISSGKSSP---------FKVSPLTFGRKKV------REGESHAENETK 314
+ S N ++I SG SS K T +KK + + K
Sbjct: 1099 RRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRK 1158
Query: 315 SEDLPSSEQMP-NDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNID 373
D+ SS D ++ S EG S+ + E + S G + + ++
Sbjct: 1159 QADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSG-DEALSKSVP 1217
Query: 374 LTIVEDEEEESVALEQAQKVRYEGSYA-LTSEEAERSDGDP 413
+T+ +D+++ A+K+ E A L+S+E SD +P
Sbjct: 1218 VTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEP 1258
Score = 33.9 bits (76), Expect = 0.29
Identities = 53/256 (20%), Positives = 103/256 (40%), Gaps = 42/256 (16%)
Query: 189 ENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEK-----------VEESRAEKIKRSSLK 237
E ++L +T ++ S EE+ ED+ ++K V+E + ++ S+ +
Sbjct: 1098 ERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKR 1157
Query: 238 KVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLT-SNHQKI--SSGKSSPFKVSP 294
K + + S + N +G ++ + + ++L S+H SSG + K P
Sbjct: 1158 KQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVP 1217
Query: 295 LTFGRKKVREGESHAEN--------ETKSEDLPSSEQMPNDQEEESFAEGHSEASLASAL 346
+T + ++ EN E +L S E +D E E EG +
Sbjct: 1218 VTVDDD---DDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPE---EGKKRTGKQNEE 1271
Query: 347 VEGEIAEEAAEKATSRGSNSGMDS----------NIDLTIVEDE--EEESVALEQAQKVR 394
G+ EEA + S + +S LT+ + E EE+ ++ ++V+
Sbjct: 1272 NPGD--EEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVK 1329
Query: 395 YEGSYALTSEEAERSD 410
++SE++E SD
Sbjct: 1330 GRNRRKVSSEDSEDSD 1345
Score = 32.7 bits (73), Expect = 0.64
Identities = 36/167 (21%), Positives = 67/167 (40%), Gaps = 23/167 (13%)
Query: 188 DENKSLEETLHTVDLSSDDDLPHDEEA----------LEDSAEEKVEESRAEKIKRSSLK 237
+EN EE + V+ SD D ++ L S E EE + K K
Sbjct: 1270 EENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKT-KPKEHKEV 1328
Query: 238 KVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTF 297
K + +K S + + + G E++ +S + S K + + + ++
Sbjct: 1329 KGRNRRKVSSEDSEDSDFQESGVS-------EEVSESEDEQRPRTRSAKKAELEENQRSY 1381
Query: 298 GRKKVR-----EGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSE 339
+KK R + +S +EN++ SE+ ++ ++EEE E E
Sbjct: 1382 KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDE 1428
Score = 28.9 bits (63), Expect = 9.3
Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 12/99 (12%)
Query: 180 VEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKV 239
++ +E+ ENKS E +++ +EE E+ EE+ +E+ K KK+
Sbjct: 1390 IKVQEDSSSENKSNSE-------EEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKI 1442
Query: 240 DSL----KKAFSRQNIEKKMNKLGTKIVSVER-REKIKK 273
+ K QN K+ + +I ER REK+++
Sbjct: 1443 RKILKDDKLRTETQNALKEEEERRKRIAEREREREKLRE 1481
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 45.8 bits (107), Expect = 7e-05
Identities = 90/461 (19%), Positives = 172/461 (37%), Gaps = 63/461 (13%)
Query: 4 DAAQAEKFQHPGSDMRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLTLLD 63
D+++ EK G D + K S SS + T + + T++ L D
Sbjct: 848 DSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDT-TIMELRD 906
Query: 64 KL------------VNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTV 111
+L V+ L +++ +E R+++ E K K Q S+
Sbjct: 907 RLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVA-ETKEKSKHLKTKTCKKVQDGLSDIA 965
Query: 112 SKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVF 171
K L+K + S T ++ ++ + K+ ++ + KV+ +++ E +
Sbjct: 966 EKFLKKDQ--SDETSEDDKKQSKKGTEEKKKPSDFKK-------KVIKMEQQYESSSDGT 1016
Query: 172 VKQPV--------SGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALE-----DS 218
K P G + K D K ++ D+ + E++ DS
Sbjct: 1017 EKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDS 1076
Query: 219 AEEKV--------EESRAEKIKRSSLKKVDSLKKAFSRQNI-EKKMNKLGTKIVSVERRE 269
+E+K E+ R + + +SS K+ D + ++ E N ++ +E RE
Sbjct: 1077 SEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRE 1136
Query: 270 KIKKSLTSNHQKISSGKSSP---------FKVSPLTFGRKKV------REGESHAENETK 314
+ S N ++I SG SS K T +KK + + K
Sbjct: 1137 RRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRK 1196
Query: 315 SEDLPSSEQMP-NDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNID 373
D+ SS D ++ S EG S+ + E + S G + + ++
Sbjct: 1197 QADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSG-DEALSKSVP 1255
Query: 374 LTIVEDEEEESVALEQAQKVRYEGSYA-LTSEEAERSDGDP 413
+T+ +D+++ A+K+ E A L+S+E SD +P
Sbjct: 1256 VTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEP 1296
Score = 33.9 bits (76), Expect = 0.29
Identities = 53/256 (20%), Positives = 103/256 (40%), Gaps = 42/256 (16%)
Query: 189 ENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEK-----------VEESRAEKIKRSSLK 237
E ++L +T ++ S EE+ ED+ ++K V+E + ++ S+ +
Sbjct: 1136 ERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKR 1195
Query: 238 KVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLT-SNHQKI--SSGKSSPFKVSP 294
K + + S + N +G ++ + + ++L S+H SSG + K P
Sbjct: 1196 KQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVP 1255
Query: 295 LTFGRKKVREGESHAEN--------ETKSEDLPSSEQMPNDQEEESFAEGHSEASLASAL 346
+T + ++ EN E +L S E +D E E EG +
Sbjct: 1256 VTVDDD---DDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPE---EGKKRTGKQNEE 1309
Query: 347 VEGEIAEEAAEKATSRGSNSGMDS----------NIDLTIVEDE--EEESVALEQAQKVR 394
G+ EEA + S + +S LT+ + E EE+ ++ ++V+
Sbjct: 1310 NPGD--EEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVK 1367
Query: 395 YEGSYALTSEEAERSD 410
++SE++E SD
Sbjct: 1368 GRNRRKVSSEDSEDSD 1383
Score = 32.7 bits (73), Expect = 0.64
Identities = 36/167 (21%), Positives = 67/167 (40%), Gaps = 23/167 (13%)
Query: 188 DENKSLEETLHTVDLSSDDDLPHDEEA----------LEDSAEEKVEESRAEKIKRSSLK 237
+EN EE + V+ SD D ++ L S E EE + K K
Sbjct: 1308 EENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKT-KPKEHKEV 1366
Query: 238 KVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTF 297
K + +K S + + + G E++ +S + S K + + + ++
Sbjct: 1367 KGRNRRKVSSEDSEDSDFQESGVS-------EEVSESEDEQRPRTRSAKKAELEENQRSY 1419
Query: 298 GRKKVR-----EGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSE 339
+KK R + +S +EN++ SE+ ++ ++EEE E E
Sbjct: 1420 KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDE 1466
Score = 28.9 bits (63), Expect = 9.3
Identities = 23/89 (25%), Positives = 40/89 (44%), Gaps = 1/89 (1%)
Query: 248 RQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREGES 307
R + + +K+ + + E K+ TS+ +K S SS K P + + E
Sbjct: 37 RLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEK 96
Query: 308 HAENETKSEDLPSSEQMPNDQEEESFAEG 336
++ET +ED S+E ND +S +G
Sbjct: 97 PLDDETVNED-ASNENSENDITMQSLPKG 124
Score = 28.9 bits (63), Expect = 9.3
Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 12/99 (12%)
Query: 180 VEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKV 239
++ +E+ ENKS E +++ +EE E+ EE+ +E+ K KK+
Sbjct: 1428 IKVQEDSSSENKSNSE-------EEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKI 1480
Query: 240 DSL----KKAFSRQNIEKKMNKLGTKIVSVER-REKIKK 273
+ K QN K+ + +I ER REK+++
Sbjct: 1481 RKILKDDKLRTETQNALKEEEERRKRIAEREREREKLRE 1519
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 45.4 bits (106), Expect = 1e-04
Identities = 67/371 (18%), Positives = 145/371 (39%), Gaps = 34/371 (9%)
Query: 70 DAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVK 129
D+++E + + +I++ S ++ + + + S + + SRK H R +
Sbjct: 46 DSLEEGELRDHCMEITIRNSPYRREDSME--DRGEEDDSLAIKPPQQMSRKEKVHHRKDE 103
Query: 130 ERMDRQCAQVKRLENN-HAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPD 188
+R ++ E HA++ R H + +EE + + +Q + +E +
Sbjct: 104 KRKEKCRHHSHSAEGGKHARVKEREHERRKRHREEQDKARREWERQ------KRREMARE 157
Query: 189 ENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSR 248
++ + L ++ + + E+ E +++ E E+ K ++ S R
Sbjct: 158 HSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMR 217
Query: 249 QNIEKKMN----------------KLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKV 292
++ K+ +LG V+ + ++ L S+ Q IS + K
Sbjct: 218 EDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER---KT 274
Query: 293 SPLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIA 352
S + G E E + E+ S +++EEE E E S + A
Sbjct: 275 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 334
Query: 353 EEAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDGD 412
EE +E+ S ++++ + + +S E+A++ EG T + + ++GD
Sbjct: 335 EEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG----TPQSSALTEGD 390
Query: 413 --PVQPAVLQV 421
P PA+L +
Sbjct: 391 YVPDSPALLPI 401
>gi|197313732 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 45.4 bits (106), Expect = 1e-04
Identities = 65/328 (19%), Positives = 129/328 (39%), Gaps = 44/328 (13%)
Query: 23 PSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLT------------LLDKLVNMLD 70
PSS P SS S L T E I + + + + L K+ ++ D
Sbjct: 554 PSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDIND 613
Query: 71 AVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKE 130
+ E+ +++ L+G K ++ T+L K + + K+ E + + K
Sbjct: 614 QMDESFRELDMECALLDGEQK---SETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKV 670
Query: 131 RMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDEN 190
++D + +++RL+ +++ + + P S+ ++ + ++ +L D
Sbjct: 671 KLDAEREKLERLQELYSEQKT----------QLDNCPESM--REQLQQQLKRDADLLDVE 718
Query: 191 KSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFS--- 247
E L L + L ++E L +V E + + R +K+ +LKK +
Sbjct: 719 SKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRK--EKISALKKQANHIV 776
Query: 248 ------RQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKK 301
+ + K+ N L I+ ++R ++ +L + +S GK P + L G
Sbjct: 777 QQAQREQDHFVKEKNNL---IMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYIS 833
Query: 302 VREGESHAENETKSEDLPSSEQMPNDQE 329
V E N T +L S Q P D +
Sbjct: 834 VNEINEPCGNST---NLSPSTQFPADAD 858
Score = 33.9 bits (76), Expect = 0.29
Identities = 38/139 (27%), Positives = 63/139 (45%), Gaps = 10/139 (7%)
Query: 283 SSGKSSPFKVSPLTFG--RKKVREGESHAENETKSEDLPSSEQMP------NDQEEESFA 334
+S +SS + P T ++ R E A ET+ L + E++ NDQ +ESF
Sbjct: 561 ASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFR 620
Query: 335 EGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVR 394
E E +L + E E EK N + + ++ IV ++ +E V L+ A++ +
Sbjct: 621 ELDMECALLDGEQKSETTELMKEKEILDHLNRKI-AELEKNIVGEKTKEKVKLD-AEREK 678
Query: 395 YEGSYALTSEEAERSDGDP 413
E L SE+ + D P
Sbjct: 679 LERLQELYSEQKTQLDNCP 697
>gi|197313730 pleckstrin homology-like domain, family B, member 2
isoform a [Homo sapiens]
Length = 1253
Score = 45.4 bits (106), Expect = 1e-04
Identities = 65/328 (19%), Positives = 129/328 (39%), Gaps = 44/328 (13%)
Query: 23 PSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLT------------LLDKLVNMLD 70
PSS P SS S L T E I + + + + L K+ ++ D
Sbjct: 554 PSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDIND 613
Query: 71 AVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKE 130
+ E+ +++ L+G K ++ T+L K + + K+ E + + K
Sbjct: 614 QMDESFRELDMECALLDGEQK---SETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKV 670
Query: 131 RMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDEN 190
++D + +++RL+ +++ + + P S+ ++ + ++ +L D
Sbjct: 671 KLDAEREKLERLQELYSEQKT----------QLDNCPESM--REQLQQQLKRDADLLDVE 718
Query: 191 KSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFS--- 247
E L L + L ++E L +V E + + R +K+ +LKK +
Sbjct: 719 SKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRK--EKISALKKQANHIV 776
Query: 248 ------RQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKK 301
+ + K+ N L I+ ++R ++ +L + +S GK P + L G
Sbjct: 777 QQAQREQDHFVKEKNNL---IMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYIS 833
Query: 302 VREGESHAENETKSEDLPSSEQMPNDQE 329
V E N T +L S Q P D +
Sbjct: 834 VNEINEPCGNST---NLSPSTQFPADAD 858
Score = 33.9 bits (76), Expect = 0.29
Identities = 38/139 (27%), Positives = 63/139 (45%), Gaps = 10/139 (7%)
Query: 283 SSGKSSPFKVSPLTFG--RKKVREGESHAENETKSEDLPSSEQMP------NDQEEESFA 334
+S +SS + P T ++ R E A ET+ L + E++ NDQ +ESF
Sbjct: 561 ASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFR 620
Query: 335 EGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVR 394
E E +L + E E EK N + + ++ IV ++ +E V L+ A++ +
Sbjct: 621 ELDMECALLDGEQKSETTELMKEKEILDHLNRKI-AELEKNIVGEKTKEKVKLD-AEREK 678
Query: 395 YEGSYALTSEEAERSDGDP 413
E L SE+ + D P
Sbjct: 679 LERLQELYSEQKTQLDNCP 697
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
Length = 1790
Score = 45.1 bits (105), Expect = 1e-04
Identities = 45/183 (24%), Positives = 78/183 (42%), Gaps = 18/183 (9%)
Query: 188 DENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFS 247
D+ ++ E T+ + + SS D + EE E S E EE + + S ++ S ++
Sbjct: 1592 DQEEATESTVESEEESSSDYTEYSEEESEFSESETTEEE--SESETPSEEEESSTPESEE 1649
Query: 248 RQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREGES 307
++ E + K IV RR +++ +++ K P + ++ E E
Sbjct: 1650 SESTESEGEKARKNIVLARRRPMVEEV-----KEVKGRKEEPQEEQ-----KEPKMEEEE 1699
Query: 308 HAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSG 367
H+E E E P+ + D E + E E S SA VEG + E ++ S S+S
Sbjct: 1700 HSEEE---ESGPAPVEESTDPEAQDIPE---EGSAESASVEGGVESEEESESGSSSSSSE 1753
Query: 368 MDS 370
S
Sbjct: 1754 SQS 1756
Score = 29.3 bits (64), Expect = 7.1
Identities = 30/129 (23%), Positives = 53/129 (41%), Gaps = 12/129 (9%)
Query: 300 KKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAE----EA 355
K + E E+ +SE+ SS+ +EE F+E + + + E E E+
Sbjct: 1588 KLTLDQEEATESTVESEEESSSDYTEYSEEESEFSESETTEEESESETPSEEEESSTPES 1647
Query: 356 AEKATSRGSNSGMDSNIDLT----IVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDG 411
E ++ NI L +VE+ +E E+ Q+ + E EE E S+
Sbjct: 1648 EESESTESEGEKARKNIVLARRRPMVEEVKEVKGRKEEPQEEQKEPK----MEEEEHSEE 1703
Query: 412 DPVQPAVLQ 420
+ PA ++
Sbjct: 1704 EESGPAPVE 1712
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 45.1 bits (105), Expect = 1e-04
Identities = 76/391 (19%), Positives = 151/391 (38%), Gaps = 62/391 (15%)
Query: 38 LNLGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDL 97
L+L T + ++ QV L +L L+ +E H+++ S++ + QN L
Sbjct: 888 LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947
Query: 98 TKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENN-------HAQLL 150
+ K + +++L + S + A++ + Q LEN AQ L
Sbjct: 948 KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007
Query: 151 RRNHFKVLIFQEENEIPASVF-----------------------VKQPVSGAVE----GK 183
K+ + Q E F V++ +S A E +
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067
Query: 184 EELPDENKSLEE------TLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLK 237
++ ++NK ++E TL + L +AL+D +EK + + ++S L
Sbjct: 1068 NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLA 1127
Query: 238 KVDSLK----KAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVS 293
+++ +K K ++ N E K +KL I + + K+ L ++ GK+ K +
Sbjct: 1128 EIEEIKCRQEKEITKLNEELKSHKL-ESIKEITNLKDAKQLLIQQKLEL-QGKADSLKAA 1185
Query: 294 PLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAE 353
E E +++ + +Q+ ++EE EA L S + E E+
Sbjct: 1186 ---------------VEQEKRNQQI-LKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGM 1229
Query: 354 EAAEKATSRGSNSGMDSNIDLTIVEDEEEES 384
+ E+ ++ + N +L V+ E + S
Sbjct: 1230 KKHEENEAKLTMQITALNENLGTVKKEWQSS 1260
Score = 38.5 bits (88), Expect = 0.012
Identities = 65/348 (18%), Positives = 139/348 (39%), Gaps = 25/348 (7%)
Query: 76 QHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQ 135
Q M+ + E + ++++ KL AS+ T+S+L + K + + +
Sbjct: 234 QTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKL 293
Query: 136 CAQVKRLENNHA----QLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKE----ELP 187
+ V L + LL++ + ++ NE S K+ + + K+ +L
Sbjct: 294 KSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS---KKNIQATLHQKDLDCQQLQ 350
Query: 188 DENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFS 247
+ E +LH + + +L EA + EE E + ++ K++ ++
Sbjct: 351 SRLSASETSLHRIHV----ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE 406
Query: 248 RQNIE--KKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREG 305
+ ++ ++N+L +K++ ER+ +++SS K + K R
Sbjct: 407 QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE 466
Query: 306 ESHAENETKSEDLPSSEQMPNDQEEESFA-EGHSEASLASALVEGE-IAEEAAEKATSRG 363
E E T S +L Q +E A + + A L A + E + + +K
Sbjct: 467 EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ 526
Query: 364 SNSGM--DSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERS 409
+ + S +++++E E E+ A QA EG A+ ++ E++
Sbjct: 527 NLEALLQKSKENISLLEKEREDLYAKIQAG----EGETAVLNQLQEKN 570
Score = 37.7 bits (86), Expect = 0.020
Identities = 71/364 (19%), Positives = 156/364 (42%), Gaps = 68/364 (18%)
Query: 39 NLGNTEEAIRDNSQ-VNAVTVLTLLDKLVNMLDAVQEN---------QHK-----MEQRQ 83
+L + A++D Q +N +T T LD++ L QE+ ++K +EQ+
Sbjct: 668 HLDTAQNALQDKQQELNKIT--TQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725
Query: 84 ISLEGSVKGIQNDL--TKLSKYQA---------------STSNTVSKLLEKSRKVSAHTR 126
LEG +K ++ D K SK QA + +SK LE +++ + TR
Sbjct: 726 EELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR 785
Query: 127 -----------AVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQP 175
++K+++ +Q + + L+ + L + K+ + N I +V Q
Sbjct: 786 LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET--KIQHEELNNRIQTTVTELQK 843
Query: 176 VSGAVEGKEELPDENKSLEETLHTV-DLSSDDDLPHDEEALEDSAEEKVEESRAEKIK-- 232
V KE L E ++++ L V D + ++E + A E +++K
Sbjct: 844 VK---MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ 900
Query: 233 -----RSSLKKVDSLKKAFSRQ-----NIEKKMNKLGTKIV----SVERREKIKKSLTSN 278
++LK+ LKK+ ++ ++ ++N + +++ ++++ EK ++ L N
Sbjct: 901 LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Query: 279 HQKISSGKSSPFKVSPLTFGRKKVRE-GESHAENETKSEDLPSSEQMPNDQEEESFAEGH 337
++ K G K+ ++ EN+ + + +++++ ++E+ S + +
Sbjct: 961 INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Query: 338 SEAS 341
E S
Sbjct: 1021 YEKS 1024
>gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo
sapiens]
Length = 1188
Score = 45.1 bits (105), Expect = 1e-04
Identities = 49/217 (22%), Positives = 94/217 (43%), Gaps = 17/217 (7%)
Query: 185 ELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVE---ESRAEKIKRSSLKKVDS 241
++ +E K LEE++ L D ++P E ++ EE ++ ES E+I+
Sbjct: 416 KVKEEKKDLEESMEEA-LKLDQEMPLTE--VKSEPEENIDSNSESEREEIE--------- 463
Query: 242 LKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKK 301
LK R+ I + +N + +I + +K+K + T N +++ K + L GRK
Sbjct: 464 LKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKN 523
Query: 302 VREGESHAENETKSEDLPSSEQMPNDQE-EESFAEGHSEASLASALVEGEIAEEAAEKAT 360
+ + + + D S E+ QE EE+ ++ SE +E + +
Sbjct: 524 TPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKY 583
Query: 361 SRGSNSGM-DSNIDLTIVEDEEEESVALEQAQKVRYE 396
RG + +++I T ++D E + VRY+
Sbjct: 584 GRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYD 620
>gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo
sapiens]
Length = 1203
Score = 45.1 bits (105), Expect = 1e-04
Identities = 49/217 (22%), Positives = 94/217 (43%), Gaps = 17/217 (7%)
Query: 185 ELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVE---ESRAEKIKRSSLKKVDS 241
++ +E K LEE++ L D ++P E ++ EE ++ ES E+I+
Sbjct: 416 KVKEEKKDLEESMEEA-LKLDQEMPLTE--VKSEPEENIDSNSESEREEIE--------- 463
Query: 242 LKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKK 301
LK R+ I + +N + +I + +K+K + T N +++ K + L GRK
Sbjct: 464 LKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKN 523
Query: 302 VREGESHAENETKSEDLPSSEQMPNDQE-EESFAEGHSEASLASALVEGEIAEEAAEKAT 360
+ + + + D S E+ QE EE+ ++ SE +E + +
Sbjct: 524 TPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKY 583
Query: 361 SRGSNSGM-DSNIDLTIVEDEEEESVALEQAQKVRYE 396
RG + +++I T ++D E + VRY+
Sbjct: 584 GRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYD 620
>gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo
sapiens]
Length = 1257
Score = 45.1 bits (105), Expect = 1e-04
Identities = 49/217 (22%), Positives = 94/217 (43%), Gaps = 17/217 (7%)
Query: 185 ELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVE---ESRAEKIKRSSLKKVDS 241
++ +E K LEE++ L D ++P E ++ EE ++ ES E+I+
Sbjct: 416 KVKEEKKDLEESMEEA-LKLDQEMPLTE--VKSEPEENIDSNSESEREEIE--------- 463
Query: 242 LKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKK 301
LK R+ I + +N + +I + +K+K + T N +++ K + L GRK
Sbjct: 464 LKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKN 523
Query: 302 VREGESHAENETKSEDLPSSEQMPNDQE-EESFAEGHSEASLASALVEGEIAEEAAEKAT 360
+ + + + D S E+ QE EE+ ++ SE +E + +
Sbjct: 524 TPKQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKY 583
Query: 361 SRGSNSGM-DSNIDLTIVEDEEEESVALEQAQKVRYE 396
RG + +++I T ++D E + VRY+
Sbjct: 584 GRGKTQKIYEASIKSTEIDDGEVLYLVHYYGWNVRYD 620
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 44.7 bits (104), Expect = 2e-04
Identities = 66/370 (17%), Positives = 144/370 (38%), Gaps = 42/370 (11%)
Query: 70 DAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVK 129
D+++E + + +I++ S ++ + + + S + + SRK H R +
Sbjct: 46 DSLEEGELRDHCMEITIRNSPYRREDSME--DRGEEDDSLAIKPPQQMSRKEKVHHRKDE 103
Query: 130 ERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDE 189
+R ++ HA++ R H + +EE + + +Q + +E +
Sbjct: 104 KRKEKW---------KHARVKEREHERRKRHREEQDKARREWERQ------KRREMAREH 148
Query: 190 NKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQ 249
++ + L ++ + + E+ E +++ E E+ K ++ S R+
Sbjct: 149 SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 208
Query: 250 NIEKKMN----------------KLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVS 293
+ K+ +LG V+ + ++ L S+ Q IS + K S
Sbjct: 209 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER---KTS 265
Query: 294 PLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAE 353
+ G E E + E+ S +++EEE E E S + AE
Sbjct: 266 SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE 325
Query: 354 EAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDGD- 412
E +E+ S ++++ + + +S E+A++ EG T + + ++GD
Sbjct: 326 EVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG----TPQSSALTEGDY 381
Query: 413 -PVQPAVLQV 421
P PA+L +
Sbjct: 382 VPDSPALLPI 391
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 44.7 bits (104), Expect = 2e-04
Identities = 69/370 (18%), Positives = 145/370 (39%), Gaps = 38/370 (10%)
Query: 70 DAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVK 129
D+++E + + +I++ S ++ + + + S + + SRK H R +
Sbjct: 46 DSLEEGELRDHCMEITIRNSPYRREDSME--DRGEEDDSLAIKPPQQMSRKEKVHHRKDE 103
Query: 130 ERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQP---VSGAVEGKEEL 186
+R +++ A+VK E H + R+ H +EE + + +Q ++ +E
Sbjct: 104 KRKEKKHARVKEKEREHER--RKRH------REEQDKARREWERQKRREMAREHSRRERG 155
Query: 187 PDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAF 246
D + L ++ + + E+ E +++ E E+ K ++ S
Sbjct: 156 NDGVCLFRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRT 215
Query: 247 SRQNIEKKMN----------------KLGTKIVSVERREKIKKSLTSNHQKISSGKSSPF 290
R++ K+ +LG V+ + ++ L S+ Q IS +
Sbjct: 216 MREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER--- 272
Query: 291 KVSPLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGE 350
K S + G E E + E+ S +++EEE E E S +
Sbjct: 273 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 332
Query: 351 IAEEAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSD 410
AEE +E+ S ++++ + + +S E+A++ EG T + + ++
Sbjct: 333 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG----TPQSSALTE 388
Query: 411 GD--PVQPAV 418
GD P PA+
Sbjct: 389 GDYVPDSPAL 398
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.302 0.120 0.308
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,253,234
Number of Sequences: 37866
Number of extensions: 726468
Number of successful extensions: 6194
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 87
Number of HSP's successfully gapped in prelim test: 598
Number of HSP's that attempted gapping in prelim test: 4806
Number of HSP's gapped (non-prelim): 1569
length of query: 425
length of database: 18,247,518
effective HSP length: 105
effective length of query: 320
effective length of database: 14,271,588
effective search space: 4566908160
effective search space used: 4566908160
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.