Search of human proteins with 4758968

Search of human proteins with 4758968

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4758968 cytohesin 3 [Homo sapiens]
         (399 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4758968 cytohesin 3 [Homo sapiens]                                 814   0.0  
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]                     689   0.0  
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]                       684   0.0  
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]                     671   0.0  
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]                       666   0.0  
gi|7019505 cytohesin 4 [Homo sapiens]                                 602   e-172
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr...   193   3e-49
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange...   187   2e-47
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]      161   1e-39
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]       161   1e-39
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]                 157   1e-38
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti...   152   5e-37
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]       147   1e-35
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]       147   1e-35
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ...   118   1e-26
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6...   118   1e-26
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]      115   5e-26
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]    112   5e-25
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]    112   5e-25
gi|48928044 F-box only protein 8 [Homo sapiens]                        89   7e-18
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa...    62   9e-10
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ...    55   1e-07
gi|24432056 hypothetical protein LOC144717 [Homo sapiens]              55   1e-07
gi|50234893 pleckstrin homology domain containing, family A (pho...    54   2e-07
gi|31377720 pleckstrin homology domain containing, family A (pho...    54   2e-07
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]             54   2e-07
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit...    52   7e-07
gi|239047795 pleckstrin homology domain containing, family A mem...    52   9e-07
gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H...    52   9e-07
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]        52   1e-06

>gi|4758968 cytohesin 3 [Homo sapiens]
          Length = 399

 Score =  814 bits (2103), Expect = 0.0
 Identities = 399/399 (100%), Positives = 399/399 (100%)

Query: 1   MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEE 60
           MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEE
Sbjct: 1   MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEE 60

Query: 61  SKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYL 120
           SKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYL
Sbjct: 61  SKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYL 120

Query: 121 GERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCN 180
           GERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCN
Sbjct: 121 GERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCN 180

Query: 181 PGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLY 240
           PGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLY
Sbjct: 181 PGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLY 240

Query: 241 ESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTT 300
           ESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTT
Sbjct: 241 ESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTT 300

Query: 301 DKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRI 360
           DKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRI
Sbjct: 301 DKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRI 360

Query: 361 SAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK 399
           SAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK
Sbjct: 361 SAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK 399


>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
          Length = 397

 Score =  689 bits (1778), Expect = 0.0
 Identities = 333/388 (85%), Positives = 359/388 (92%)

Query: 12  VPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIA 71
           VP DL+ EER+EL +IRRRK+EL+ DI+RLK EIAEV  EI+NL S EE K  QRNKQ+A
Sbjct: 8   VPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVA 67

Query: 72  MGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVL 131
           MGRKKFNMDPKKGIQFLIENDLL+++ ED+AQFLYKGEGLNKT IGDYLGERDEFNI+VL
Sbjct: 68  MGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVL 127

Query: 132 QAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCY 191
            AFVELHEF DLNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYC CN GVFQSTDTCY
Sbjct: 128 HAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCY 187

Query: 192 VLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIP 251
           VLSFAIIMLNTSLHN NV+DKPT ERFIAMNRGIN+GGDLPEELLRNLYESIKNEPFKIP
Sbjct: 188 VLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIP 247

Query: 252 EDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLE 311
           EDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLE
Sbjct: 248 EDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLE 307

Query: 312 NLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEW 371
           NLSIREVED +KPNCFELY P +K QVIKACKTEADGRVVEGNH VYRISAP+PEEKEEW
Sbjct: 308 NLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEW 367

Query: 372 MKSIKASISRDPFYDMLATRKRRIANKK 399
           +K IKA+ISRDPFY+MLA RK+++++ K
Sbjct: 368 IKCIKAAISRDPFYEMLAARKKKVSSTK 395


>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
          Length = 398

 Score =  684 bits (1766), Expect = 0.0
 Identities = 333/389 (85%), Positives = 359/389 (92%), Gaps = 1/389 (0%)

Query: 12  VPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIA 71
           VP DL+ EER+EL +IRRRK+EL+ DI+RLK EIAEV  EI+NL S EE K  QRNKQ+A
Sbjct: 8   VPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVA 67

Query: 72  MGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVL 131
           MGRKKFNMDPKKGIQFLIENDLL+++ ED+AQFLYKGEGLNKT IGDYLGERDEFNI+VL
Sbjct: 68  MGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVL 127

Query: 132 QAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCY 191
            AFVELHEF DLNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYC CN GVFQSTDTCY
Sbjct: 128 HAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCY 187

Query: 192 VLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIP 251
           VLSFAIIMLNTSLHN NV+DKPT ERFIAMNRGIN+GGDLPEELLRNLYESIKNEPFKIP
Sbjct: 188 VLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIP 247

Query: 252 EDDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPL 310
           EDDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPL
Sbjct: 248 EDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPL 307

Query: 311 ENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEE 370
           ENLSIREVED +KPNCFELY P +K QVIKACKTEADGRVVEGNH VYRISAP+PEEKEE
Sbjct: 308 ENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEE 367

Query: 371 WMKSIKASISRDPFYDMLATRKRRIANKK 399
           W+K IKA+ISRDPFY+MLA RK+++++ K
Sbjct: 368 WIKCIKAAISRDPFYEMLAARKKKVSSTK 396


>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
          Length = 399

 Score =  671 bits (1731), Expect = 0.0
 Identities = 321/397 (80%), Positives = 365/397 (91%), Gaps = 4/397 (1%)

Query: 3   EDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESK 62
           EDG  E    P DL+ EER EL +IRRRK+EL+ +I+RL+ E++E M+E++ L + E SK
Sbjct: 2   EDGVYE----PPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSK 57

Query: 63  TTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGE 122
           T QRN+++AMGRKKFNMDPKKGIQFL+EN+LLQ++PE++A+FLYKGEGLNKT IGDYLGE
Sbjct: 58  TLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGE 117

Query: 123 RDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPG 182
           R+E N+ VL AFV+LHEF DLNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYCLCNPG
Sbjct: 118 REELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPG 177

Query: 183 VFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYES 242
           VFQSTDTCYVLSFA+IMLNTSLHN NVRDKP  ERF+AMNRGINEGGDLPEELLRNLY+S
Sbjct: 178 VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDS 237

Query: 243 IKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDK 302
           I+NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDK
Sbjct: 238 IRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDK 297

Query: 303 EPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISA 362
           EPRGIIPLENLSIREV+DPRKPNCFELY P++KGQ+IKACKTEADGRVVEGNH+VYRISA
Sbjct: 298 EPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISA 357

Query: 363 PSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK 399
           P+ EEK+EW+KSI+A++S DPFY+MLA RK+RI+ KK
Sbjct: 358 PTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKK 394


>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
          Length = 400

 Score =  666 bits (1719), Expect = 0.0
 Identities = 321/398 (80%), Positives = 365/398 (91%), Gaps = 5/398 (1%)

Query: 3   EDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESK 62
           EDG  E    P DL+ EER EL +IRRRK+EL+ +I+RL+ E++E M+E++ L + E SK
Sbjct: 2   EDGVYE----PPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSK 57

Query: 63  TTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGE 122
           T QRN+++AMGRKKFNMDPKKGIQFL+EN+LLQ++PE++A+FLYKGEGLNKT IGDYLGE
Sbjct: 58  TLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGE 117

Query: 123 RDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPG 182
           R+E N+ VL AFV+LHEF DLNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYCLCNPG
Sbjct: 118 REELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPG 177

Query: 183 VFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYES 242
           VFQSTDTCYVLSFA+IMLNTSLHN NVRDKP  ERF+AMNRGINEGGDLPEELLRNLY+S
Sbjct: 178 VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDS 237

Query: 243 IKNEPFKIPEDDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEYTTD 301
           I+NEPFKIPEDDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFEYTTD
Sbjct: 238 IRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTD 297

Query: 302 KEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRIS 361
           KEPRGIIPLENLSIREV+DPRKPNCFELY P++KGQ+IKACKTEADGRVVEGNH+VYRIS
Sbjct: 298 KEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRIS 357

Query: 362 APSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK 399
           AP+ EEK+EW+KSI+A++S DPFY+MLA RK+RI+ KK
Sbjct: 358 APTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKK 395


>gi|7019505 cytohesin 4 [Homo sapiens]
          Length = 394

 Score =  602 bits (1552), Expect = e-172
 Identities = 283/387 (73%), Positives = 338/387 (87%)

Query: 13  PEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIAM 72
           P +LS  E EEL  I+  +K+L++DI++LK EIA+V  +ID   S EES+  Q+ K++ +
Sbjct: 8   PAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCI 67

Query: 73  GRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQ 132
           GRKKFNMDP KGIQ+ IE+ LL    +D+A+FLYKGEGLNKT IG YLGERD  N++VLQ
Sbjct: 68  GRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQ 127

Query: 133 AFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYV 192
           AFV+ HEFA+LNLVQALRQFLWSFRLPGEAQKIDRMMEAFA+RYCLCNPGVFQSTDTCYV
Sbjct: 128 AFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYV 187

Query: 193 LSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPE 252
           LSF+IIMLNTSLHN NVRD+P  ERF++MNRGIN G DLPE+ LRNL++SIK+EPF IPE
Sbjct: 188 LSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPE 247

Query: 253 DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLEN 312
           DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFE+TTDKEPRGIIPLEN
Sbjct: 248 DDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLEN 307

Query: 313 LSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWM 372
           LS+++V+DP+KP C ELYNPS +GQ IKACKT+ DGRVVEG H  YRISA S EE+++W+
Sbjct: 308 LSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWI 367

Query: 373 KSIKASISRDPFYDMLATRKRRIANKK 399
           +SI+ASI+R PFYD+++TRK++IA+K+
Sbjct: 368 ESIRASITRVPFYDLVSTRKKKIASKQ 394


>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
           protein 1 [Homo sapiens]
          Length = 1849

 Score =  193 bits (490), Expect = 3e-49
 Identities = 98/211 (46%), Positives = 142/211 (67%), Gaps = 3/211 (1%)

Query: 45  IAEVMTEIDNLTSVEESKTTQRNKQIA-MGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQ 103
           I    T++    + E+ +  ++ K+I   G   FN  PK+GIQ+L E  +L ++PED+AQ
Sbjct: 676 IGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQ 735

Query: 104 FLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQ 163
           FL++ E L+ T +G++LG+ D+FN +V+ A+V+ H+F+  + V ALR FL  FRLPGEAQ
Sbjct: 736 FLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQ 795

Query: 164 KIDRMMEAFASRYCLCNPG--VFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAM 221
           KIDR+ME FA+RY  CN G  +F S DT YVL+++IIML T LH+  V++K T E++I M
Sbjct: 796 KIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKM 855

Query: 222 NRGINEGGDLPEELLRNLYESIKNEPFKIPE 252
           NRGIN+  DLPEE L  +Y  I  +   + E
Sbjct: 856 NRGINDSKDLPEEYLSAIYNEIAGKKISMKE 886


>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
           factor 2 [Homo sapiens]
          Length = 1785

 Score =  187 bits (474), Expect = 2e-47
 Identities = 96/190 (50%), Positives = 132/190 (69%), Gaps = 2/190 (1%)

Query: 65  QRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERD 124
           Q+ + I  G + FN  PK+GIQFL E  +L +S ED+AQFL++ E L+ T +GD+LG+  
Sbjct: 642 QQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSA 701

Query: 125 EFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPG-- 182
            FN +V+ A+V+  +F +   V ALR FL  FRLPGEAQKIDR+ME FA+RY  CN G  
Sbjct: 702 RFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT 761

Query: 183 VFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYES 242
           +F S DT YVL+++IIML T LH+  V++K T E++I MNRGIN+  DLPEE L ++YE 
Sbjct: 762 LFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEE 821

Query: 243 IKNEPFKIPE 252
           I+ +   + E
Sbjct: 822 IEGKKIAMKE 831


>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
          Length = 1114

 Score =  161 bits (407), Expect = 1e-39
 Identities = 82/194 (42%), Positives = 127/194 (65%), Gaps = 6/194 (3%)

Query: 66  RNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERD- 124
           R +   +G   FN  P+KG+Q+LIE   +  +P  VA FL + +GL++ +IG++LG R  
Sbjct: 510 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 569

Query: 125 EFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGV- 183
           +FN  VL   V+  +F+ + L +ALR+F    R+ GEAQK++R++EAF+ RYC+CNPGV 
Sbjct: 570 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 629

Query: 184 --FQSTDTCYVLSFAIIMLNTSLHNHNVRD--KPTAERFIAMNRGINEGGDLPEELLRNL 239
             F++ DT ++L+FAII+LNT +++ NV+   K   E FI   RG+++G D+P E+L  +
Sbjct: 630 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 689

Query: 240 YESIKNEPFKIPED 253
           YE I+    K  ED
Sbjct: 690 YERIRKRELKTNED 703


>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
          Length = 963

 Score =  161 bits (407), Expect = 1e-39
 Identities = 82/194 (42%), Positives = 127/194 (65%), Gaps = 6/194 (3%)

Query: 66  RNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERD- 124
           R +   +G   FN  P+KG+Q+LIE   +  +P  VA FL + +GL++ +IG++LG R  
Sbjct: 524 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 583

Query: 125 EFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGV- 183
           +FN  VL   V+  +F+ + L +ALR+F    R+ GEAQK++R++EAF+ RYC+CNPGV 
Sbjct: 584 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 643

Query: 184 --FQSTDTCYVLSFAIIMLNTSLHNHNVRD--KPTAERFIAMNRGINEGGDLPEELLRNL 239
             F++ DT ++L+FAII+LNT +++ NV+   K   E FI   RG+++G D+P E+L  +
Sbjct: 644 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 703

Query: 240 YESIKNEPFKIPED 253
           YE I+    K  ED
Sbjct: 704 YERIRKRELKTNED 717


>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
          Length = 759

 Score =  157 bits (398), Expect = 1e-38
 Identities = 95/284 (33%), Positives = 151/284 (53%), Gaps = 35/284 (12%)

Query: 5   GGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMT-------------- 50
           G  +G   P+    EE EE  ++ R  +    D+E+L        +              
Sbjct: 258 GAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKD 317

Query: 51  ------------EIDNLTSVEE---SKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQ 95
                         +N  S +    S  T R +   +G   FN++P KGIQFLI    + 
Sbjct: 318 ALQAMILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIP 377

Query: 96  SSPEDVAQFLYKGEGLNKTVIGDYLGE-RDEFNIKVLQAFVELHEFADLNLVQALRQFLW 154
            +P  VA FL + +GL++ +IG++LG  + +FN  VL   V+  +F+ + L +ALR+F  
Sbjct: 378 DTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQA 437

Query: 155 SFRLPGEAQKIDRMMEAFASRYCLCNPGV---FQSTDTCYVLSFAIIMLNTSLHNHNVRD 211
             R+ GEAQK++R++EAF+ RYC+CNP V   F + DT ++L+FAII+LNT +++ N++ 
Sbjct: 438 HIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKP 497

Query: 212 --KPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPED 253
             K   E FI   RG+++G D+P EL+  +YE I+ +  K  ED
Sbjct: 498 DRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNED 541


>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
           exchange factor 1 [Homo sapiens]
          Length = 1859

 Score =  152 bits (384), Expect = 5e-37
 Identities = 82/193 (42%), Positives = 122/193 (63%), Gaps = 7/193 (3%)

Query: 66  RNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPE--DVAQFLYKGEGLNKTVIGDYLGER 123
           + K +  G ++FN  PKKGIQFL E  LL    +  +VAQ+L +   L+K +IG+++ +R
Sbjct: 699 KKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDR 758

Query: 124 DEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGV 183
              NI +L++FV    F  L L +ALR +L +FRLPGEA  I R++EAF  R+  CN   
Sbjct: 759 K--NIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSP 816

Query: 184 FQSTDTCYVLSFAIIMLNTSLHNHNVRDK---PTAERFIAMNRGINEGGDLPEELLRNLY 240
           F ++D C+ L++A+IMLNT  HNHNVR +    T E F    +G+N G D  +++L ++Y
Sbjct: 817 FANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMY 876

Query: 241 ESIKNEPFKIPED 253
            +IKNE   +PE+
Sbjct: 877 HAIKNEEIVMPEE 889


>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
          Length = 949

 Score =  147 bits (372), Expect = 1e-35
 Identities = 75/194 (38%), Positives = 125/194 (64%), Gaps = 6/194 (3%)

Query: 66  RNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERD- 124
           + +   +G   FN  P+KGIQ+LIE   L  +P  VA F+ + +GL++ +IG++LG R  
Sbjct: 548 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 607

Query: 125 EFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGV- 183
           +FN  VL   V+  +F+ ++L  ALR+F    R+ GEAQK++R++EAF+ RYC+CNP + 
Sbjct: 608 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 667

Query: 184 --FQSTDTCYVLSFAIIMLNTSLHNHNVR--DKPTAERFIAMNRGINEGGDLPEELLRNL 239
             F++ DT ++L+FAII+LNT +++ +V+   K   + FI   RG++ G D+P +LL  +
Sbjct: 668 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 727

Query: 240 YESIKNEPFKIPED 253
           Y+ I+    +  +D
Sbjct: 728 YQRIQGRELRTNDD 741


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score =  147 bits (372), Expect = 1e-35
 Identities = 75/194 (38%), Positives = 125/194 (64%), Gaps = 6/194 (3%)

Query: 66  RNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERD- 124
           + +   +G   FN  P+KGIQ+LIE   L  +P  VA F+ + +GL++ +IG++LG R  
Sbjct: 753 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 812

Query: 125 EFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGV- 183
           +FN  VL   V+  +F+ ++L  ALR+F    R+ GEAQK++R++EAF+ RYC+CNP + 
Sbjct: 813 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 872

Query: 184 --FQSTDTCYVLSFAIIMLNTSLHNHNVR--DKPTAERFIAMNRGINEGGDLPEELLRNL 239
             F++ DT ++L+FAII+LNT +++ +V+   K   + FI   RG++ G D+P +LL  +
Sbjct: 873 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 932

Query: 240 YESIKNEPFKIPED 253
           Y+ I+    +  +D
Sbjct: 933 YQRIQGRELRTNDD 946


>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
           isoform b [Homo sapiens]
          Length = 513

 Score =  118 bits (295), Expect = 1e-26
 Identities = 59/154 (38%), Positives = 96/154 (62%)

Query: 101 VAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPG 160
           +A+ LY+ +   ++ +  +LG+ +EF+  V + +++  +F  + L Q+LR F  +F L G
Sbjct: 54  LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 113

Query: 161 EAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIA 220
           E Q+ +R++  F++RY  CNP    S D  + L+ AI++LNT LH HN+  K T + FIA
Sbjct: 114 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 173

Query: 221 MNRGINEGGDLPEELLRNLYESIKNEPFKIPEDD 254
             +G+NEG D  ++LL+ LY SIKNE  +   DD
Sbjct: 174 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 207


>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
           isoform a [Homo sapiens]
          Length = 1047

 Score =  118 bits (295), Expect = 1e-26
 Identities = 59/154 (38%), Positives = 96/154 (62%)

Query: 101 VAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPG 160
           +A+ LY+ +   ++ +  +LG+ +EF+  V + +++  +F  + L Q+LR F  +F L G
Sbjct: 588 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 647

Query: 161 EAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIA 220
           E Q+ +R++  F++RY  CNP    S D  + L+ AI++LNT LH HN+  K T + FIA
Sbjct: 648 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 707

Query: 221 MNRGINEGGDLPEELLRNLYESIKNEPFKIPEDD 254
             +G+NEG D  ++LL+ LY SIKNE  +   DD
Sbjct: 708 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 741


>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
          Length = 1024

 Score =  115 bits (289), Expect = 5e-26
 Identities = 59/154 (38%), Positives = 90/154 (58%)

Query: 101 VAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPG 160
           +A+ LY+ +G  K  +  +LG+ ++F+  V   +++   F  + L QALR FL    L G
Sbjct: 561 LAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMG 620

Query: 161 EAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIA 220
           E Q+ +R++  F+ RY  CNP    S D  + L+ A+++LNT LH HN+  + T   FI 
Sbjct: 621 ETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIG 680

Query: 221 MNRGINEGGDLPEELLRNLYESIKNEPFKIPEDD 254
              G+N+GGD P ELL+ LY SIKNE  +   D+
Sbjct: 681 NLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDE 714


>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
          Length = 771

 Score =  112 bits (281), Expect = 5e-25
 Identities = 61/156 (39%), Positives = 94/156 (60%), Gaps = 2/156 (1%)

Query: 101 VAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPG 160
           +A+ LY  EG  +  +   LG+ +EF+  V   ++   +F+ L L  ALR FL +F L G
Sbjct: 317 LARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMG 376

Query: 161 EAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIA 220
           E Q+ +R++  F+ RYC CNP    S D  + L+ A+++LNT LH HN+  K + ++FIA
Sbjct: 377 ETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIA 436

Query: 221 MNRGINEGGDLPEELLRNLYESIKNEPFK--IPEDD 254
               +N+G D  ++LL+ LY SIKNE  +  I ED+
Sbjct: 437 NLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDE 472


>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
          Length = 1056

 Score =  112 bits (281), Expect = 5e-25
 Identities = 55/155 (35%), Positives = 95/155 (61%)

Query: 100 DVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLP 159
           ++A  LY+ EG  K+ +  YL + ++F+  V + ++   +F   +L +ALR FL +  L 
Sbjct: 590 NLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649

Query: 160 GEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFI 219
           GE Q+ +R++  F+ R+  CNPG+F S D+ + L+ AI++LNT LH  N+    + + FI
Sbjct: 650 GETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFI 709

Query: 220 AMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDD 254
               G+ +GG+ P+ELL+ LY SI++E  +   D+
Sbjct: 710 TNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDE 744


>gi|48928044 F-box only protein 8 [Homo sapiens]
          Length = 319

 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 53/180 (29%), Positives = 96/180 (53%), Gaps = 11/180 (6%)

Query: 69  QIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNI 128
           Q+  G   FN +P +G+ + +   +L  SP+++A+F++    LN   +  YL ER +   
Sbjct: 138 QLDEGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRD--- 194

Query: 129 KVLQAFVELHEFADLNLVQALRQFLWSFRLPGE-AQKIDRMMEAFASRYCLCNPGVFQ-- 185
            VL   V LH F +  L  ALR+F      P E  + ++ ++  F+ R+C CNP + +  
Sbjct: 195 -VLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMREL 253

Query: 186 --STDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESI 243
             S D  YVL +++I+L+  L + +V++K +   FI   R      ++ E+ + +LY++I
Sbjct: 254 GLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTR--RAAQNISEDFVGHLYDNI 311


>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
           sapiens]
          Length = 748

 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 10/111 (9%)

Query: 269 GWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFE 328
           GWL K GG VKTW  RWF+L  + LYYF+   + +P G I L    + E           
Sbjct: 24  GWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSE----------H 73

Query: 329 LYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASI 379
             N  + G+ +       D   +  NH  Y + A +  + E+W+KSI+  I
Sbjct: 74  PCNEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVI 124


>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
           sapiens]
          Length = 1048

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 19/110 (17%)

Query: 267 REGWLLKLGGR-VKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPN 325
           + GWL K     VK W +RWF+L D CL+Y++   ++   G IPL +  +  V+     +
Sbjct: 62  KAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNIS 121

Query: 326 CFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSI 375
               +   H G                     Y  SA SPEE+E W++++
Sbjct: 122 RKHTFKAEHAGV------------------RTYFFSAESPEEQEAWIQAM 153


>gi|24432056 hypothetical protein LOC144717 [Homo sapiens]
          Length = 249

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 25/54 (46%), Positives = 33/54 (61%)

Query: 266 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVE 319
           D  G+L K GGR   + RRWF+L  N L+YFE    +EP G+I LE  ++  VE
Sbjct: 19  DNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGVIILEGCTVELVE 72


>gi|50234893 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 1 [Homo
           sapiens]
          Length = 404

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 31/117 (26%), Positives = 54/117 (46%), Gaps = 26/117 (22%)

Query: 267 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENL----SIREVEDPR 322
           + G+ +K G  +K WKRR+F L +N + YF+   +KEP  +IPL+ +      ++ +   
Sbjct: 194 KAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMM 253

Query: 323 KPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASI 379
           + N FE+   S                        + + A SPEE   W+K++  +I
Sbjct: 254 RDNLFEIVTTSR----------------------TFYVQADSPEEMHSWIKAVSGAI 288


>gi|31377720 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 1 [Homo
           sapiens]
          Length = 404

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 31/117 (26%), Positives = 54/117 (46%), Gaps = 26/117 (22%)

Query: 267 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENL----SIREVEDPR 322
           + G+ +K G  +K WKRR+F L +N + YF+   +KEP  +IPL+ +      ++ +   
Sbjct: 194 KAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMM 253

Query: 323 KPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASI 379
           + N FE+   S                        + + A SPEE   W+K++  +I
Sbjct: 254 RDNLFEIVTTSR----------------------TFYVQADSPEEMHSWIKAVSGAI 288


>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
          Length = 698

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 34/117 (29%), Positives = 60/117 (51%), Gaps = 16/117 (13%)

Query: 267 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREV----EDPR 322
           + GWL K    +K W++RWF+L  + L+Y++   + +P+G I L+   + E+    EDP 
Sbjct: 40  KAGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPG 99

Query: 323 KPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASI 379
           K + FE+ +P   G+  K          V  N     + A S  + E+W+++I+  I
Sbjct: 100 K-HLFEI-SPGGAGEREK----------VPANPEALLLMASSQRDMEDWVQAIRRVI 144


>gi|158631203 dual adaptor of phosphotyrosine and
           3-phosphoinositides [Homo sapiens]
          Length = 280

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 32/82 (39%), Positives = 40/82 (48%), Gaps = 1/82 (1%)

Query: 267 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVE-DPRKPN 325
           +EG+L K GG VKTWK RWF L  N L YF+     EP  I+ L   S  + +    + N
Sbjct: 167 KEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVN 226

Query: 326 CFELYNPSHKGQVIKACKTEAD 347
           CF L  P     +      EAD
Sbjct: 227 CFCLVFPFRTFYLCAKTGVEAD 248


>gi|239047795 pleckstrin homology domain containing, family A member
           7 [Homo sapiens]
          Length = 1121

 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 10/124 (8%)

Query: 269 GWLLKLGGR-VKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCF 327
           GWL K     ++ WKRRWF+L D CL+Y++ + ++   G IPL +  I  V    + +  
Sbjct: 169 GWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRK 228

Query: 328 ELYNPSHKGQVIKACKTEADGRVVEGNHV-VYRISAPSPEEKEEWMKSI--------KAS 378
             +   H G       +   G   E + +  Y  SA + E+   W++++        ++S
Sbjct: 229 YSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSS 288

Query: 379 ISRD 382
           + RD
Sbjct: 289 LKRD 292


>gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo
           sapiens]
          Length = 713

 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 26/81 (32%), Positives = 42/81 (51%), Gaps = 4/81 (4%)

Query: 265 PDREGWLLKL----GGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVED 320
           PD +GWLL      G     W+RRWF+L  + LY++    D++  G+I + N S+    D
Sbjct: 397 PDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHD 456

Query: 321 PRKPNCFELYNPSHKGQVIKA 341
            +K   F+L +  +K  +  A
Sbjct: 457 QKKKYVFQLTHDVYKPFIFAA 477


>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
          Length = 1047

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 48/167 (28%), Positives = 78/167 (46%), Gaps = 37/167 (22%)

Query: 225 INEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHT---------FFNPDREGWLLKLG 275
           I EG  L E +     E + N+       DG ++ +T         + N  ++G+LLK G
Sbjct: 431 IVEGYYLKEPVPMQDQEQVLNDTV-----DGKEIYNTIRRKTKDAFYKNIVKKGYLLKKG 485

Query: 276 GRVKTWKRRWFIL--TDNCLYYFEYTTDK-EPRGIIPLENLSIREVEDPR--KPNCFELY 330
            + K WK  +FIL  +D  L YFE      +P+G+I L   S+  V D    +PNCF++ 
Sbjct: 486 -KGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQI- 543

Query: 331 NPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKA 377
                  V++    E         H ++  +  +PE+ E+WMK ++A
Sbjct: 544 -------VVQHFSEE---------HYIFYFAGETPEQAEDWMKGLQA 574


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.138    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,895,243
Number of Sequences: 37866
Number of extensions: 735161
Number of successful extensions: 2835
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 114
Number of HSP's successfully gapped in prelim test: 108
Number of HSP's that attempted gapping in prelim test: 2521
Number of HSP's gapped (non-prelim): 361
length of query: 399
length of database: 18,247,518
effective HSP length: 104
effective length of query: 295
effective length of database: 14,309,454
effective search space: 4221288930
effective search space used: 4221288930
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.