Search of human proteins with 4758964

Search of human proteins with 4758964

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
         (398 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]                       815   0.0  
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]                     808   0.0  
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]                       693   0.0  
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]                     686   0.0  
gi|4758968 cytohesin 3 [Homo sapiens]                                 684   0.0  
gi|7019505 cytohesin 4 [Homo sapiens]                                 575   e-164
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr...   198   6e-51
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange...   194   9e-50
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]      161   8e-40
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]       161   8e-40
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]                 156   3e-38
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti...   149   4e-36
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]       147   1e-35
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]       147   1e-35
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]      117   2e-26
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ...   114   2e-25
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6...   114   2e-25
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]    112   8e-25
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]    111   1e-24
gi|48928044 F-box only protein 8 [Homo sapiens]                        85   1e-16
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ...    60   3e-09
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa...    58   1e-08
gi|50234893 pleckstrin homology domain containing, family A (pho...    58   2e-08
gi|31377720 pleckstrin homology domain containing, family A (pho...    58   2e-08
gi|239047795 pleckstrin homology domain containing, family A mem...    55   1e-07
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]        55   1e-07
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]       55   1e-07
gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H...    55   1e-07
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit...    52   9e-07
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa...    51   2e-06

>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
          Length = 398

 Score =  815 bits (2105), Expect = 0.0
 Identities = 398/398 (100%), Positives = 398/398 (100%)

Query: 1   MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM 60
           MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM
Sbjct: 1   MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM 60

Query: 61  QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD 120
           QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD
Sbjct: 61  QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD 120

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF 180
           EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF 180

Query: 181 QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK 240
           QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK
Sbjct: 181 QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK 240

Query: 241 NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKE 300
           NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKE
Sbjct: 241 NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKE 300

Query: 301 PRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAP 360
           PRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAP
Sbjct: 301 PRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAP 360

Query: 361 TPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH 398
           TPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH
Sbjct: 361 TPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH 398


>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
          Length = 397

 Score =  808 bits (2087), Expect = 0.0
 Identities = 397/398 (99%), Positives = 397/398 (99%), Gaps = 1/398 (0%)

Query: 1   MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM 60
           MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM
Sbjct: 1   MEEDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNM 60

Query: 61  QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD 120
           QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD
Sbjct: 61  QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD 120

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF 180
           EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF
Sbjct: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVF 180

Query: 181 QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK 240
           QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK
Sbjct: 181 QSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIK 240

Query: 241 NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKE 300
           NEPFKIPEDDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFEYTTDKE
Sbjct: 241 NEPFKIPEDDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEYTTDKE 299

Query: 301 PRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAP 360
           PRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAP
Sbjct: 300 PRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAP 359

Query: 361 TPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH 398
           TPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH
Sbjct: 360 TPEEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKRH 397


>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
          Length = 400

 Score =  693 bits (1789), Expect = 0.0
 Identities = 329/395 (83%), Positives = 366/395 (92%)

Query: 3   EDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQR 62
           ED  Y P DLT EER ELENIRRRKQELL +IQRL++E++E  +E+E L + E  K +QR
Sbjct: 2   EDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQR 61

Query: 63  NKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEF 122
           N+++AMGRKKFNMDPKKGIQFL+EN+LL+NT E+IA+FLYKGEGLNKTAIGDYLGER+E 
Sbjct: 62  NRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREEL 121

Query: 123 NIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQS 182
           N+ VLHAFV+LHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYC CN GVFQS
Sbjct: 122 NLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQS 181

Query: 183 TDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNE 242
           TDTCYVLSFA+IMLNTSLHNPNV+DKP +ERF+AMNRGIN+GGDLPEELLRNLY+SI+NE
Sbjct: 182 TDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNE 241

Query: 243 PFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR 302
           PFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR
Sbjct: 242 PFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR 301

Query: 303 GIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTP 362
           GIIPLENLSIREV+D +KPNCFELYIP+NK Q+IKACKTEADGRVVEGNH VYRISAPT 
Sbjct: 302 GIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQ 361

Query: 363 EEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKR 397
           EEK+EWIK I+AA+S DPFYEMLAARKK++S  K+
Sbjct: 362 EEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKK 396


>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
          Length = 399

 Score =  686 bits (1771), Expect = 0.0
 Identities = 328/395 (83%), Positives = 365/395 (92%), Gaps = 1/395 (0%)

Query: 3   EDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQR 62
           ED  Y P DLT EER ELENIRRRKQELL +IQRL++E++E  +E+E L + E  K +QR
Sbjct: 2   EDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQR 61

Query: 63  NKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEF 122
           N+++AMGRKKFNMDPKKGIQFL+EN+LL+NT E+IA+FLYKGEGLNKTAIGDYLGER+E 
Sbjct: 62  NRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREEL 121

Query: 123 NIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQS 182
           N+ VLHAFV+LHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYC CN GVFQS
Sbjct: 122 NLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQS 181

Query: 183 TDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNE 242
           TDTCYVLSFA+IMLNTSLHNPNV+DKP +ERF+AMNRGIN+GGDLPEELLRNLY+SI+NE
Sbjct: 182 TDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNE 241

Query: 243 PFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR 302
           PFKIPEDDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFEYTTDKEPR
Sbjct: 242 PFKIPEDDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEYTTDKEPR 300

Query: 303 GIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTP 362
           GIIPLENLSIREV+D +KPNCFELYIP+NK Q+IKACKTEADGRVVEGNH VYRISAPT 
Sbjct: 301 GIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQ 360

Query: 363 EEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKR 397
           EEK+EWIK I+AA+S DPFYEMLAARKK++S  K+
Sbjct: 361 EEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKK 395


>gi|4758968 cytohesin 3 [Homo sapiens]
          Length = 399

 Score =  684 bits (1766), Expect = 0.0
 Identities = 333/389 (85%), Positives = 359/389 (92%), Gaps = 1/389 (0%)

Query: 8   VPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVA 67
           VP DL+ EER+EL +IRRRK+EL+ DI+RLK EIAEV  EI+NL S EE K  QRNKQ+A
Sbjct: 12  VPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIA 71

Query: 68  MGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVL 127
           MGRKKFNMDPKKGIQFLIENDLL+++ ED+AQFLYKGEGLNKT IGDYLGERDEFNI+VL
Sbjct: 72  MGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVL 131

Query: 128 HAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCY 187
            AFVELHEF DLNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYC CN GVFQSTDTCY
Sbjct: 132 QAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCY 191

Query: 188 VLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIP 247
           VLSFAIIMLNTSLHN NV+DKPT ERFIAMNRGIN+GGDLPEELLRNLYESIKNEPFKIP
Sbjct: 192 VLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIP 251

Query: 248 EDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPL 307
           EDDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPL
Sbjct: 252 EDDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPL 310

Query: 308 ENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEE 367
           ENLSIREVED +KPNCFELY P +K QVIKACKTEADGRVVEGNH VYRISAP+PEEKEE
Sbjct: 311 ENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEE 370

Query: 368 WIKCIKAAISRDPFYEMLAARKKKVSSTK 396
           W+K IKA+ISRDPFY+MLA RK+++++ K
Sbjct: 371 WMKSIKASISRDPFYDMLATRKRRIANKK 399


>gi|7019505 cytohesin 4 [Homo sapiens]
          Length = 394

 Score =  575 bits (1483), Expect = e-164
 Identities = 273/386 (70%), Positives = 330/386 (85%), Gaps = 1/386 (0%)

Query: 9   PSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQRNKQVAM 68
           P++L++ E +EL+ I+  +++LL DIQ+LKDEIA+V  +I+   S EE +  Q+ K++ +
Sbjct: 8   PAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELCI 67

Query: 69  GRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLH 128
           GRKKFNMDP KGIQ+ IE+ LL    +DIA+FLYKGEGLNKTAIG YLGERD  N+QVL 
Sbjct: 68  GRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVLQ 127

Query: 129 AFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYV 188
           AFV+ HEF +LNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYC CN GVFQSTDTCYV
Sbjct: 128 AFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCYV 187

Query: 189 LSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPE 248
           LSF+IIMLNTSLHNPNV+D+P  ERF++MNRGIN+G DLPE+ LRNL++SIK+EPF IPE
Sbjct: 188 LSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIPE 247

Query: 249 DDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLE 308
           DDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFE+TTDKEPRGIIPLE
Sbjct: 248 DDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLE 306

Query: 309 NLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEW 368
           NLS+++V+D KKP C ELY P  + Q IKACKT+ DGRVVEG H  YRISA + EE+++W
Sbjct: 307 NLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQW 366

Query: 369 IKCIKAAISRDPFYEMLAARKKKVSS 394
           I+ I+A+I+R PFY++++ RKKK++S
Sbjct: 367 IESIRASITRVPFYDLVSTRKKKIAS 392


>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
           protein 1 [Homo sapiens]
          Length = 1849

 Score =  198 bits (504), Expect = 6e-51
 Identities = 100/211 (47%), Positives = 143/211 (67%), Gaps = 3/211 (1%)

Query: 41  IAEVANEIENLGSTEERKNMQRNKQVA-MGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQ 99
           I   + ++    + E+ + +++ K++   G   FN  PK+GIQ+L E  +L  T EDIAQ
Sbjct: 676 IGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQ 735

Query: 100 FLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQ 159
           FL++ E L+ T +G++LG+ D+FN +V++A+V+ H+F+  + V ALR FL  FRLPGEAQ
Sbjct: 736 FLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQ 795

Query: 160 KIDRMMEAFAQRYCQCNNG--VFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAM 217
           KIDR+ME FA RY +CN G  +F S DT YVL+++IIML T LH+P VK+K T E++I M
Sbjct: 796 KIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKM 855

Query: 218 NRGINDGGDLPEELLRNLYESIKNEPFKIPE 248
           NRGIND  DLPEE L  +Y  I  +   + E
Sbjct: 856 NRGINDSKDLPEEYLSAIYNEIAGKKISMKE 886


>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
           factor 2 [Homo sapiens]
          Length = 1785

 Score =  194 bits (494), Expect = 9e-50
 Identities = 98/190 (51%), Positives = 133/190 (70%), Gaps = 2/190 (1%)

Query: 61  QRNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD 120
           Q+ + +  G + FN  PK+GIQFL E  +L  + EDIAQFL++ E L+ T +GD+LG+  
Sbjct: 642 QQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSA 701

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNG-- 178
            FN +V++A+V+  +F +   V ALR FL  FRLPGEAQKIDR+ME FA RY +CN G  
Sbjct: 702 RFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT 761

Query: 179 VFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYES 238
           +F S DT YVL+++IIML T LH+P VK+K T E++I MNRGIND  DLPEE L ++YE 
Sbjct: 762 LFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEE 821

Query: 239 IKNEPFKIPE 248
           I+ +   + E
Sbjct: 822 IEGKKIAMKE 831


>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
          Length = 1114

 Score =  161 bits (408), Expect = 8e-40
 Identities = 84/194 (43%), Positives = 127/194 (65%), Gaps = 6/194 (3%)

Query: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120
           R +   +G   FN  P+KG+Q+LIE   + +T   +A FL + +GL++  IG++LG R  
Sbjct: 510 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 569

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179
           +FN  VL   V+  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC CN GV 
Sbjct: 570 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 629

Query: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVKD--KPTVERFIAMNRGINDGGDLPEELLRNL 235
             F++ DT ++L+FAII+LNT +++PNVK   K  +E FI   RG++DG D+P E+L  +
Sbjct: 630 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 689

Query: 236 YESIKNEPFKIPED 249
           YE I+    K  ED
Sbjct: 690 YERIRKRELKTNED 703


>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
          Length = 963

 Score =  161 bits (408), Expect = 8e-40
 Identities = 84/194 (43%), Positives = 127/194 (65%), Gaps = 6/194 (3%)

Query: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120
           R +   +G   FN  P+KG+Q+LIE   + +T   +A FL + +GL++  IG++LG R  
Sbjct: 524 RKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQK 583

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179
           +FN  VL   V+  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC CN GV 
Sbjct: 584 QFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVV 643

Query: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVKD--KPTVERFIAMNRGINDGGDLPEELLRNL 235
             F++ DT ++L+FAII+LNT +++PNVK   K  +E FI   RG++DG D+P E+L  +
Sbjct: 644 RQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGI 703

Query: 236 YESIKNEPFKIPED 249
           YE I+    K  ED
Sbjct: 704 YERIRKRELKTNED 717


>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
          Length = 759

 Score =  156 bits (395), Expect = 3e-38
 Identities = 82/194 (42%), Positives = 126/194 (64%), Gaps = 6/194 (3%)

Query: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGE-RD 120
           R +   +G   FN++P KGIQFLI    + +T   +A FL + +GL++  IG++LG  + 
Sbjct: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179
           +FN  VL   V+  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC CN  V 
Sbjct: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467

Query: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVKD--KPTVERFIAMNRGINDGGDLPEELLRNL 235
             F + DT ++L+FAII+LNT +++PN+K   K  +E FI   RG++DG D+P EL+  +
Sbjct: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527

Query: 236 YESIKNEPFKIPED 249
           YE I+ +  K  ED
Sbjct: 528 YERIQQKELKSNED 541


>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
           exchange factor 1 [Homo sapiens]
          Length = 1859

 Score =  149 bits (376), Expect = 4e-36
 Identities = 79/193 (40%), Positives = 121/193 (62%), Gaps = 7/193 (3%)

Query: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCE--DIAQFLYKGEGLNKTAIGDYLGER 119
           + K +  G ++FN  PKKGIQFL E  LL    +  ++AQ+L +   L+K  IG+++ +R
Sbjct: 699 KKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDR 758

Query: 120 DEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV 179
              NI +L +FV    F  L L +ALR +L +FRLPGEA  I R++EAF +R+  CN   
Sbjct: 759 K--NIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSP 816

Query: 180 FQSTDTCYVLSFAIIMLNTSLHNPNVKDK---PTVERFIAMNRGINDGGDLPEELLRNLY 236
           F ++D C+ L++A+IMLNT  HN NV+ +    T+E F    +G+N G D  +++L ++Y
Sbjct: 817 FANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMY 876

Query: 237 ESIKNEPFKIPED 249
            +IKNE   +PE+
Sbjct: 877 HAIKNEEIVMPEE 889


>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
          Length = 949

 Score =  147 bits (372), Expect = 1e-35
 Identities = 76/194 (39%), Positives = 126/194 (64%), Gaps = 6/194 (3%)

Query: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120
           + +   +G   FN  P+KGIQ+LIE   L +T   +A F+ + +GL++  IG++LG R  
Sbjct: 548 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 607

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179
           +FN  VL   V+  +F+ ++L  ALR+F    R+ GEAQK++R++EAF+QRYC CN  + 
Sbjct: 608 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 667

Query: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVK--DKPTVERFIAMNRGINDGGDLPEELLRNL 235
             F++ DT ++L+FAII+LNT +++P+VK   K  ++ FI   RG+++G D+P +LL  +
Sbjct: 668 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 727

Query: 236 YESIKNEPFKIPED 249
           Y+ I+    +  +D
Sbjct: 728 YQRIQGRELRTNDD 741


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score =  147 bits (372), Expect = 1e-35
 Identities = 76/194 (39%), Positives = 126/194 (64%), Gaps = 6/194 (3%)

Query: 62  RNKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERD- 120
           + +   +G   FN  P+KGIQ+LIE   L +T   +A F+ + +GL++  IG++LG R  
Sbjct: 753 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 812

Query: 121 EFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGV- 179
           +FN  VL   V+  +F+ ++L  ALR+F    R+ GEAQK++R++EAF+QRYC CN  + 
Sbjct: 813 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 872

Query: 180 --FQSTDTCYVLSFAIIMLNTSLHNPNVK--DKPTVERFIAMNRGINDGGDLPEELLRNL 235
             F++ DT ++L+FAII+LNT +++P+VK   K  ++ FI   RG+++G D+P +LL  +
Sbjct: 873 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 932

Query: 236 YESIKNEPFKIPED 249
           Y+ I+    +  +D
Sbjct: 933 YQRIQGRELRTNDD 946


>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
          Length = 1024

 Score =  117 bits (292), Expect = 2e-26
 Identities = 61/154 (39%), Positives = 91/154 (59%)

Query: 97  IAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPG 156
           +A+ LY+ +G  K  +  +LG+ ++F+  V   +++   FT + L QALR FL    L G
Sbjct: 561 LAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMG 620

Query: 157 EAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIA 216
           E Q+ +R++  F+QRY QCN     S D  + L+ A+++LNT LH  N+  + T   FI 
Sbjct: 621 ETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIG 680

Query: 217 MNRGINDGGDLPEELLRNLYESIKNEPFKIPEDD 250
              G+NDGGD P ELL+ LY SIKNE  +   D+
Sbjct: 681 NLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDE 714


>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
           isoform b [Homo sapiens]
          Length = 513

 Score =  114 bits (285), Expect = 2e-25
 Identities = 97/347 (27%), Positives = 159/347 (45%), Gaps = 74/347 (21%)

Query: 97  IAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPG 156
           +A+ LY+ +   ++ +  +LG+ +EF+  V   +++  +FT + L Q+LR F  +F L G
Sbjct: 54  LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 113

Query: 157 EAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIA 216
           E Q+ +R++  F+ RY  CN     S D  + L+ AI++LNT LH  N+  K T + FIA
Sbjct: 114 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 173

Query: 217 MNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDG------------------------- 251
             +G+N+G D  ++LL+ LY SIKNE  +   DD                          
Sbjct: 174 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRI 233

Query: 252 NDLTHTFF----NPD----REGWLLK-----LGGGRVKTWKRRW----FILTDNCLYY-- 292
              T+ F     +P+    + G+L +     + G +    KR W     +L    LY   
Sbjct: 234 GSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQK 293

Query: 293 FEYTTDK-----EPRGIIPLEN-LSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGR 346
            EY  +K     + +  + + + L+ +  +  KKPN F+L             KT AD R
Sbjct: 294 DEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKL-------------KT-ADWR 339

Query: 347 VVEGNHTVYRISAPTPEEKEEW---IKCIKAAISRDPFYEMLAARKK 390
           V+            +PEE + W   I C+ A  S  PF   + ++KK
Sbjct: 340 VL-------LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKK 379


>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
           isoform a [Homo sapiens]
          Length = 1047

 Score =  114 bits (285), Expect = 2e-25
 Identities = 97/347 (27%), Positives = 159/347 (45%), Gaps = 74/347 (21%)

Query: 97  IAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPG 156
           +A+ LY+ +   ++ +  +LG+ +EF+  V   +++  +FT + L Q+LR F  +F L G
Sbjct: 588 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 647

Query: 157 EAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIA 216
           E Q+ +R++  F+ RY  CN     S D  + L+ AI++LNT LH  N+  K T + FIA
Sbjct: 648 ETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIA 707

Query: 217 MNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDG------------------------- 251
             +G+N+G D  ++LL+ LY SIKNE  +   DD                          
Sbjct: 708 NLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRI 767

Query: 252 NDLTHTFF----NPD----REGWLLK-----LGGGRVKTWKRRW----FILTDNCLYY-- 292
              T+ F     +P+    + G+L +     + G +    KR W     +L    LY   
Sbjct: 768 GSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQK 827

Query: 293 FEYTTDK-----EPRGIIPLEN-LSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGR 346
            EY  +K     + +  + + + L+ +  +  KKPN F+L             KT AD R
Sbjct: 828 DEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKL-------------KT-ADWR 873

Query: 347 VVEGNHTVYRISAPTPEEKEEW---IKCIKAAISRDPFYEMLAARKK 390
           V+            +PEE + W   I C+ A  S  PF   + ++KK
Sbjct: 874 VL-------LFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKK 913


>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
          Length = 771

 Score =  112 bits (279), Expect = 8e-25
 Identities = 65/172 (37%), Positives = 99/172 (57%), Gaps = 9/172 (5%)

Query: 88  DLLKNTCEDI-------AQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLN 140
           D L N C+ +       A+ LY  EG  +  +   LG+ +EF+  V   ++   +F+ L 
Sbjct: 301 DPLANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLT 360

Query: 141 LVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSL 200
           L  ALR FL +F L GE Q+ +R++  F++RYCQCN     S D  + L+ A+++LNT L
Sbjct: 361 LDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDL 420

Query: 201 HNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFK--IPEDD 250
           H  N+  K + ++FIA    +NDG D  ++LL+ LY SIKNE  +  I ED+
Sbjct: 421 HGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDE 472


>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
          Length = 1056

 Score =  111 bits (277), Expect = 1e-24
 Identities = 55/155 (35%), Positives = 94/155 (60%)

Query: 96  DIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLP 155
           ++A  LY+ EG  K+ +  YL + ++F+  V   ++   +F   +L +ALR FL +  L 
Sbjct: 590 NLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649

Query: 156 GEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFI 215
           GE Q+ +R++  F++R+  CN G+F S D+ + L+ AI++LNT LH  N+    + + FI
Sbjct: 650 GETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFI 709

Query: 216 AMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDD 250
               G+ DGG+ P+ELL+ LY SI++E  +   D+
Sbjct: 710 TNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDE 744


>gi|48928044 F-box only protein 8 [Homo sapiens]
          Length = 319

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 53/180 (29%), Positives = 96/180 (53%), Gaps = 11/180 (6%)

Query: 65  QVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFNI 124
           Q+  G   FN +P +G+ + +   +L ++ ++IA+F++    LN   +  YL ER +   
Sbjct: 138 QLDEGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRD--- 194

Query: 125 QVLHAFVELHEFTDLNLVQALRQFLWSFRLPGE-AQKIDRMMEAFAQRYCQCNNGVFQ-- 181
            VL   V LH F +  L  ALR+F      P E  + ++ ++  F+ R+C CN  + +  
Sbjct: 195 -VLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMREL 253

Query: 182 --STDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESI 239
             S D  YVL +++I+L+  L +P+VK+K +   FI   R      ++ E+ + +LY++I
Sbjct: 254 GLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTR--RAAQNISEDFVGHLYDNI 311


>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
           sapiens]
          Length = 1048

 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 34/113 (30%), Positives = 53/113 (46%), Gaps = 18/113 (15%)

Query: 263 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPN 322
           + GWL K     VK W +RWF+L D CL+Y++   ++   G IPL +  +  V+ S    
Sbjct: 62  KAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPS---- 117

Query: 323 CFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAA 375
                     D + +    +A+   V      Y  SA +PEE+E WI+ +  A
Sbjct: 118 ----------DNISRKHTFKAEHAGVR----TYFFSAESPEEQEAWIQAMGEA 156


>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
           sapiens]
          Length = 748

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 37/115 (32%), Positives = 55/115 (47%), Gaps = 17/115 (14%)

Query: 265 GWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIRE---VEDSKKP 321
           GWL K GG  VKTW  RWF+L  + LYYF+   + +P G I L    + E    E++   
Sbjct: 24  GWLRKQGGF-VKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENPGK 82

Query: 322 NCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAI 376
             FE+    ++D+             +  NH  Y + A T  + E+W+K I+  I
Sbjct: 83  FLFEVVPGGDRDR-------------MTANHESYLLMASTQNDMEDWVKSIRRVI 124


>gi|50234893 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 1 [Homo
           sapiens]
          Length = 404

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 34/121 (28%), Positives = 62/121 (51%), Gaps = 23/121 (19%)

Query: 261 PDREGWLLKLG-----GGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREV 315
           P ++  ++K G     G  +K WKRR+F L +N + YF+   +KEP  +IPL+   + +V
Sbjct: 186 PPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLK--EVHKV 243

Query: 316 EDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAA 375
           ++ K+    ++ + DN  +++   +T             + + A +PEE   WIK +  A
Sbjct: 244 QECKQS---DIMMRDNLFEIVTTSRT-------------FYVQADSPEEMHSWIKAVSGA 287

Query: 376 I 376
           I
Sbjct: 288 I 288


>gi|31377720 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 1 [Homo
           sapiens]
          Length = 404

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 34/121 (28%), Positives = 62/121 (51%), Gaps = 23/121 (19%)

Query: 261 PDREGWLLKLG-----GGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREV 315
           P ++  ++K G     G  +K WKRR+F L +N + YF+   +KEP  +IPL+   + +V
Sbjct: 186 PPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLK--EVHKV 243

Query: 316 EDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAA 375
           ++ K+    ++ + DN  +++   +T             + + A +PEE   WIK +  A
Sbjct: 244 QECKQS---DIMMRDNLFEIVTTSRT-------------FYVQADSPEEMHSWIKAVSGA 287

Query: 376 I 376
           I
Sbjct: 288 I 288


>gi|239047795 pleckstrin homology domain containing, family A member
           7 [Homo sapiens]
          Length = 1121

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 29/112 (25%), Positives = 51/112 (45%), Gaps = 1/112 (0%)

Query: 265 GWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREV-EDSKKPNC 323
           GWL K     ++ WKRRWF+L D CL+Y++ + ++   G IPL +  I  V  + +    
Sbjct: 169 GWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRK 228

Query: 324 FELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAA 375
           +         + +    + A  +  +     Y  SA T E+   W++ +  A
Sbjct: 229 YSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQA 280


>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
          Length = 1047

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 37/117 (31%), Positives = 60/117 (51%), Gaps = 24/117 (20%)

Query: 263 REGWLLKLGGGRVKTWKRRWFIL--TDNCLYYFEYTTDK-EPRGIIPLENLSIREVEDSK 319
           ++G+LLK G G  K WK  +FIL  +D  L YFE      +P+G+I L   S+  V DS 
Sbjct: 477 KKGYLLKKGKG--KRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSL 534

Query: 320 --KPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKA 374
             +PNCF++ +    ++                 H ++  +  TPE+ E+W+K ++A
Sbjct: 535 FGRPNCFQIVVQHFSEE-----------------HYIFYFAGETPEQAEDWMKGLQA 574


>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
          Length = 870

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 37/117 (31%), Positives = 60/117 (51%), Gaps = 24/117 (20%)

Query: 263 REGWLLKLGGGRVKTWKRRWFIL--TDNCLYYFEYTTDK-EPRGIIPLENLSIREVEDSK 319
           ++G+LLK G G  K WK  +FIL  +D  L YFE      +P+G+I L   S+  V DS 
Sbjct: 300 KKGYLLKKGKG--KRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSL 357

Query: 320 --KPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKA 374
             +PNCF++ +    ++                 H ++  +  TPE+ E+W+K ++A
Sbjct: 358 FGRPNCFQIVVQHFSEE-----------------HYIFYFAGETPEQAEDWMKGLQA 397


>gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo
           sapiens]
          Length = 713

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 26/69 (37%), Positives = 38/69 (55%), Gaps = 3/69 (4%)

Query: 261 PDREGWLLKL---GGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVED 317
           PD +GWLL     GG     W+RRWF+L  + LY++    D++  G+I + N S+    D
Sbjct: 397 PDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHD 456

Query: 318 SKKPNCFEL 326
            KK   F+L
Sbjct: 457 QKKKYVFQL 465


>gi|158631203 dual adaptor of phosphotyrosine and
           3-phosphoinositides [Homo sapiens]
          Length = 280

 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 38/117 (32%), Positives = 53/117 (45%), Gaps = 24/117 (20%)

Query: 263 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDS-KKP 321
           +EG+L K GG  VKTWK RWF L  N L YF+     EP  I+ L   S  + + S ++ 
Sbjct: 167 KEGYLTKQGG-LVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERV 225

Query: 322 NCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAISR 378
           NCF L  P                         + + A T  E +EWIK ++  +S+
Sbjct: 226 NCFCLVFP----------------------FRTFYLCAKTGVEADEWIKILRWKLSQ 260


>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
           sapiens]
          Length = 631

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 35/114 (30%), Positives = 51/114 (44%), Gaps = 21/114 (18%)

Query: 263 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPN 322
           ++G+L K G  R + W  RWF L  +CL YF     KE RGIIPL+             +
Sbjct: 219 KQGYLWKRGHLR-RNWAERWFQLQPSCLCYFGSEECKEKRGIIPLD------------AH 265

Query: 323 CFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEEWIKCIKAAI 376
           C    +PD   +    C        V+  +  Y +SA    +++EW   I+ AI
Sbjct: 266 CCVEVLPDRDGKRCMFC--------VKTANRTYEMSASDTRQRQEWTAAIQMAI 311


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,338,598
Number of Sequences: 37866
Number of extensions: 704785
Number of successful extensions: 3646
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 132
Number of HSP's successfully gapped in prelim test: 138
Number of HSP's that attempted gapping in prelim test: 3255
Number of HSP's gapped (non-prelim): 472
length of query: 398
length of database: 18,247,518
effective HSP length: 104
effective length of query: 294
effective length of database: 14,309,454
effective search space: 4206979476
effective search space used: 4206979476
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.