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Search of human proteins with 4758172
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
precursor [Homo sapiens]
(513 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1 precu... 1019 0.0
gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2 pre... 981 0.0
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 175 1e-43
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 103 5e-22
gi|217330641 IWS1 homolog [Homo sapiens] 99 1e-20
gi|60097902 filaggrin [Homo sapiens] 92 1e-18
gi|24415404 MDN1, midasin homolog [Homo sapiens] 91 3e-18
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 88 2e-17
gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homo... 85 1e-16
gi|210032580 SET domain containing 1B [Homo sapiens] 80 3e-15
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 79 8e-15
gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens] 76 6e-14
gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens] 76 6e-14
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 75 1e-13
gi|4504487 histidine rich calcium binding protein precursor [Hom... 75 1e-13
gi|16445033 ACRC protein [Homo sapiens] 74 2e-13
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 74 2e-13
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens] 74 2e-13
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 74 3e-13
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 73 5e-13
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 73 7e-13
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 71 2e-12
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 71 2e-12
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 71 2e-12
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 71 3e-12
gi|50962882 G patch domain containing 8 [Homo sapiens] 70 4e-12
gi|150170670 piccolo isoform 2 [Homo sapiens] 69 8e-12
gi|150378539 piccolo isoform 1 [Homo sapiens] 69 8e-12
gi|157738619 smoothelin-like 1 [Homo sapiens] 69 8e-12
gi|55741677 SET domain containing 1A [Homo sapiens] 69 1e-11
>gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
precursor [Homo sapiens]
Length = 513
Score = 1019 bits (2636), Expect = 0.0
Identities = 513/513 (100%), Positives = 513/513 (100%)
Query: 1 MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEE 60
MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEE
Sbjct: 1 MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEE 60
Query: 61 QANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSG 120
QANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSG
Sbjct: 61 QANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSG 120
Query: 121 PGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEG 180
PGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEG
Sbjct: 121 PGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEG 180
Query: 181 GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK 240
GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK
Sbjct: 181 GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK 240
Query: 241 ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSN 300
ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSN
Sbjct: 241 ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSN 300
Query: 301 SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVV 360
SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVV
Sbjct: 301 SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVV 360
Query: 361 SESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPE 420
SESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPE
Sbjct: 361 SESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPE 420
Query: 421 SPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ 480
SPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ
Sbjct: 421 SPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ 480
Query: 481 LKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY 513
LKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY
Sbjct: 481 LKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY 513
>gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2
precursor [Homo sapiens]
Length = 497
Score = 981 bits (2536), Expect = 0.0
Identities = 497/513 (96%), Positives = 497/513 (96%), Gaps = 16/513 (3%)
Query: 1 MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEE 60
MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPL
Sbjct: 1 MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPL--------------- 45
Query: 61 QANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSG 120
ANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSG
Sbjct: 46 -ANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSG 104
Query: 121 PGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEG 180
PGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEG
Sbjct: 105 PGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEG 164
Query: 181 GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK 240
GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK
Sbjct: 165 GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK 224
Query: 241 ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSN 300
ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSN
Sbjct: 225 ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSN 284
Query: 301 SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVV 360
SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVV
Sbjct: 285 SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVV 344
Query: 361 SESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPE 420
SESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPE
Sbjct: 345 SESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPE 404
Query: 421 SPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ 480
SPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ
Sbjct: 405 SPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ 464
Query: 481 LKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY 513
LKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY
Sbjct: 465 LKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY 497
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 175 bits (443), Expect = 1e-43
Identities = 134/461 (29%), Positives = 208/461 (45%), Gaps = 16/461 (3%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQY 83
+++S DS + K +++ + +S S+ S +S + + D SDS+ S S D
Sbjct: 613 SSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSS--DNSDSSDSSNSSNSSDSSD 670
Query: 84 IYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGD--DDSGPGPKDRQEGGNSRLGSDEDSD 141
+ S S D D D S D D S D + NS SD DS
Sbjct: 671 SSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSN-SSDSDSS 729
Query: 142 DTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKP--EGGDSTQESESEEHWVGGGSD 199
++ +S+ S + D+++ S D+ D +S + DS+ S+S S
Sbjct: 730 NSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSS 789
Query: 200 GESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQL 259
S D S D SD +S S +S +S S +S ++S +++ DS S
Sbjct: 790 NSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSS- 848
Query: 260 LEHPSRKIFRKSRISEEDDRSELDD--NNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDS 317
+ +S S D S+ D N++ SDS E+SNS D+ S DS DS
Sbjct: 849 -DGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDS--DS 905
Query: 318 QEDSKENLSQEESQNVDGP-SSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVE 376
+ S + S + S + D SS SS +N S NSS+S + S + D+ + + S
Sbjct: 906 SDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSS-N 964
Query: 377 DQEDSDSSEEDSSHTLSHSKSESREEQADS-ESSESLNFSEESPESPEDENSSSQEGLQS 435
+ SDS+ DSS + + S S + +DS +SS+S N S+ S S ++S+S + S
Sbjct: 965 SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024
Query: 436 HSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSE 476
SS S S +S D SDS DSS S + SNS++S SS+
Sbjct: 1025 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1065
Score = 172 bits (435), Expect = 9e-43
Identities = 126/498 (25%), Positives = 206/498 (41%), Gaps = 14/498 (2%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQY 83
N++S DS + + S SS S SS+ + D S+S++S + S D
Sbjct: 653 NSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDS 712
Query: 84 IYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDE----D 139
S S+ + D D S D D + +S SD D
Sbjct: 713 SDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772
Query: 140 SDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSD 199
S D+ +S S ++ D++ S D+ + DS S +S +
Sbjct: 773 SSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDS 832
Query: 200 GESSHG-DGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQ 258
+SS+ D S+ D SD S RS+ NS +S S S ++S+ +++ +S S
Sbjct: 833 SDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSS 892
Query: 259 LLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSK---- 314
S S S S N++ S+S++NSNS D+ S DS
Sbjct: 893 DSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSN 952
Query: 315 -GDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTS 373
DS S + S + S + SS+SS ++ S +SS+S + S + D+ D + S
Sbjct: 953 SSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1012
Query: 374 YVEDQEDSDSSEEDSSHTLSHSKSESREEQADS----ESSESLNFSEESPESPEDENSSS 429
S+ DSS++ S S + +DS +SS+S N S+ S S ++S S
Sbjct: 1013 SDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS 1072
Query: 430 QEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESR 489
+ S SS S S +S + D SDS DSS S + S+S++S SS+ + +
Sbjct: 1073 SDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1132
Query: 490 KLTVDAYHNKPIGDQDDN 507
+ D+ ++ D ++
Sbjct: 1133 SDSSDSSNSSDSSDSSES 1150
Score = 171 bits (434), Expect = 1e-42
Identities = 126/502 (25%), Positives = 205/502 (40%), Gaps = 25/502 (4%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQY 83
+++S +S E + + +SS+SS + S+ + D SDS+ S + S D
Sbjct: 692 SSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSN 751
Query: 84 IYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDE-DSDD 142
+ S D D D S D + D + NS S+ DS D
Sbjct: 752 SSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSD 811
Query: 143 TIQASEESAPQGQDSAQ--DTTSESRELDNEDRVDSKPEG-------GDSTQESESEEHW 193
+ +S+ + DS+ D++ S D+ D DS DS+ S+S +
Sbjct: 812 SSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSS 871
Query: 194 VGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQD 253
S S D +E + SD S S+ +S +S S S ++SE +N+ D
Sbjct: 872 DSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSD 931
Query: 254 SGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDS 313
+ S + S + D + D +N+ + S+S+++S+S ++ S DS
Sbjct: 932 NSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDS 991
Query: 314 KGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTS 373
S N S + SS SS +N S NSS+S + S D+ D + S
Sbjct: 992 SDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1051
Query: 374 Y--------VEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDE 425
+ + SDSS+ S S+S + S+SS+S N S+ S S +
Sbjct: 1052 SDSSNSSDSSDSSDSSDSSDSSDS-------SDSSDSSESSDSSDSSNSSDSSDSSDSSD 1104
Query: 426 NSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIE 485
+S S + S SS S S +S D SDS DSS S + S+S+ES SS+ + +
Sbjct: 1105 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSD 1164
Query: 486 IESRKLTVDAYHNKPIGDQDDN 507
+ D+ + D D+
Sbjct: 1165 SSDSSDSSDSSDSSNSSDSSDS 1186
Score = 170 bits (431), Expect = 2e-42
Identities = 126/455 (27%), Positives = 207/455 (45%), Gaps = 20/455 (4%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQY 83
NN ++D+++ ++ + +SS+SS S S ++ S+S+ + SD
Sbjct: 531 NNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDS 590
Query: 84 IYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDT 143
+ S S+ D DS D + DS D + + SD +S D+
Sbjct: 591 SDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDS 650
Query: 144 IQASEESAPQGQDSAQDTTSESRELDNEDRVDSK--PEGGDSTQESESEEHWVGGGSDGE 201
S+ S ++ D++ S D+ DS + DS+ S S E +
Sbjct: 651 SDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSE----SSDSSD 706
Query: 202 SSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLE 261
SS D S+ D S + S S+ NS +S S +S ++S+ +N+ DS S
Sbjct: 707 SSDSDSSDSSD----SSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSS 762
Query: 262 HPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDS 321
+ S S S+ D S D+N SDS+++SNS D+ S DS S DS
Sbjct: 763 NSSDSS-DSSDSSDSSDSSNSSDSNDSSN-SSDSSDSSNSSDSSNSSDSSDSSDSSDSDS 820
Query: 322 KENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDS 381
+ +S N SS+SS +N S +SS+S + S+S + +S D DS
Sbjct: 821 SNS---SDSSN----SSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDS 873
Query: 382 DSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAE 441
+S DSS + ++S + + +DS +S + S+ S S ++S+S + +S +SS
Sbjct: 874 SNSS-DSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDN 932
Query: 442 SQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSE 476
S S +S + D SDS DSS S + SNS++S +SS+
Sbjct: 933 SNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSD 967
Score = 170 bits (430), Expect = 3e-42
Identities = 138/485 (28%), Positives = 215/485 (44%), Gaps = 37/485 (7%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQY 83
+++S DS + + +SS SS+ S SS+ + D SDS+ S E S D
Sbjct: 838 SSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSD-SSDSSNSSDSSDSSDSNESSNSSD--- 893
Query: 84 IYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDE-DSDD 142
+ S S+ D + D S D D +S SD DS D
Sbjct: 894 ----SSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSD 949
Query: 143 TIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKP--EGGDSTQESESEEHWVGGGSDG 200
+ +S+ S ++ D+ S+S D+ D +S + DS+ S+S + S
Sbjct: 950 SSNSSDSSNSSDSSNSSDS-SDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSD 1008
Query: 201 ESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLL 260
S D S D SD S S+ +S +S S +S ++S+ +N+ DS S
Sbjct: 1009 SSDSSDSSNSSDSSNSSDSSNS--SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDS--- 1063
Query: 261 EHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQED 320
S S+ D S+ D++ E SDS+++SNS D+ S DS DS +
Sbjct: 1064 ----------SDSSDSSDSSDSSDSSDSSE-SSDSSDSSNSSDSSDSSDSSDS-SDSSDS 1111
Query: 321 SKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQED 380
S + S + S + D SS+SS ++ S NSS+S + S D+ D + S D D
Sbjct: 1112 SDSSDSSDSSNSSD--SSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDS--SDSSD 1167
Query: 381 SDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSA 440
S S + S + S S+S + S+SS+S + S+ S S ++S S + S SS
Sbjct: 1168 SSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1227
Query: 441 ESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKP 500
S S ES D SDS DSS S + S+S++S S+ + N E +S+ + + +N
Sbjct: 1228 SSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSD----SNDESDSQSKSGNGNNNGS 1283
Query: 501 IGDQD 505
D D
Sbjct: 1284 DSDSD 1288
Score = 169 bits (429), Expect = 4e-42
Identities = 131/486 (26%), Positives = 214/486 (44%), Gaps = 26/486 (5%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVS--SEEQANEDPSDSTQSEEGLGSDDH 81
++ S DS + + +SS SS+ S S S+ + D SDS+ S +G SD
Sbjct: 797 SSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSS 856
Query: 82 QYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSD 141
+RS D D D S D + + +S SD DS
Sbjct: 857 ----------NRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSS 906
Query: 142 DTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGE 201
D+ +S+ S ++ D++ S DN + DS DS+ S+S S
Sbjct: 907 DSSNSSDSS---DSSNSSDSSESSNSSDNSNSSDSS-NSSDSSDSSDSSNSSDSSNSSDS 962
Query: 202 SSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLE 261
S+ D S+ + S S+ +S +S S S ++S+ +++ DS S
Sbjct: 963 SNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSS 1022
Query: 262 HPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDS 321
+ S S S+ D S+ D++ + SDS+++SNS D+ S DS DS + S
Sbjct: 1023 NSSDS----SNSSDSSDSSDSSDSSDSSD-SSDSSDSSNSSDSSDSSDSSDSS-DSSDSS 1076
Query: 322 KENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDS 381
+ S E S + D SS SS ++ S +SS+S + S D+ + + S D DS
Sbjct: 1077 DSSDSSESSDSSD--SSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDS--SDSSDS 1132
Query: 382 DSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAE 441
S + S+ + S SES + S+SS+S + S+ S S ++S+S + S SS
Sbjct: 1133 SDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1192
Query: 442 SQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPI 501
S S +S D SDS DSS S + S+S++S SS+ ++ + + D+ ++
Sbjct: 1193 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDS 1252
Query: 502 GDQDDN 507
D D+
Sbjct: 1253 SDSSDS 1258
Score = 168 bits (426), Expect = 9e-42
Identities = 124/489 (25%), Positives = 206/489 (42%), Gaps = 11/489 (2%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQY 83
+++S DS + + + S S S S++ + D SDS+ S + S D
Sbjct: 752 SSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSD 811
Query: 84 IYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGP----KDRQEGGNSRLGSDED 139
+ S ++ + D + + D+ DS G +R + NS SD
Sbjct: 812 SSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSS 871
Query: 140 SDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSD 199
S +S+ + S +S+S + D DS DS+ S S + S
Sbjct: 872 DSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSS-NSSDSSDSSNSSDSSESSNSS 930
Query: 200 GESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQL 259
S+ D S D SD S S + NS+ S ++S+ +N+ DS S
Sbjct: 931 DNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSD 990
Query: 260 LEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKS-DSTENSNSRDTGLSQPRRDSKGDSQ 318
S + D D +N+ + S DS+ +S+S D+ S DS DS
Sbjct: 991 SSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDS-SDSS 1049
Query: 319 EDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQ 378
+ S + S + S + D SS+SS ++ S +SSES + S + D+ D + S D
Sbjct: 1050 DSSDSSNSSDSSDSSD--SSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDS--SDS 1105
Query: 379 EDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSS 438
DS S + S + S + S+S + S+SS+S N S+ S S ++S S + S S
Sbjct: 1106 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDS 1165
Query: 439 SAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHN 498
S S S +S + SDS DSS S + S+S++S SS+ + + + D+ +
Sbjct: 1166 SDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1225
Query: 499 KPIGDQDDN 507
D +++
Sbjct: 1226 SDSSDSNES 1234
Score = 167 bits (424), Expect = 2e-41
Identities = 135/497 (27%), Positives = 219/497 (44%), Gaps = 30/497 (6%)
Query: 24 NNESEDSEEWKGHLAQ-APTPPLESSESSEG-SKVSSEEQANEDPSDSTQSEEGLGSDDH 81
+++S DS+ + + + + +SS+SS+ S SS + D SDS+ S + S D
Sbjct: 563 SSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 622
Query: 82 QYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDE-DS 140
+ S S D K D D + D+ + DS D NS SD DS
Sbjct: 623 ----KSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSS----DSSNSSNSSDSSDSSDS 674
Query: 141 DDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDG 200
D+ +S+ S + D+++ S D+ D DS + S S + SD
Sbjct: 675 SDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDS 734
Query: 201 E--SSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQ 258
S+ D S+ D SD +S S+ NS +S S +S ++S +++ DS S
Sbjct: 735 SDSSNSSDSSDSSDSSNSSDSSDS--SDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSS 792
Query: 259 LLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQ 318
S S S+ D S+ D+++ SDS+ +S+S D+ S DS S
Sbjct: 793 DSSDSSNSS-DSSNSSDSSDSSDSSDSDSSNS--SDSSNSSDSSDSSNSSDSSDSSDSSD 849
Query: 319 EDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQ 378
++ ++ +S N SS+SS ++ S+ +SS+S + S + D+ D + S D
Sbjct: 850 GSDSDSSNRSDSSN----SSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDS 905
Query: 379 EDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSS 438
DS +S + S + S SES +S SS+S N S+ S S +S S S +S
Sbjct: 906 SDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNS 965
Query: 439 SAESQSEESHSEE--------DDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRK 490
S S S S S + D SDS DSS S + SNS++S SS+ + + +
Sbjct: 966 SDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSS 1025
Query: 491 LTVDAYHNKPIGDQDDN 507
+ ++ + D D+
Sbjct: 1026 DSSNSSDSSDSSDSSDS 1042
Score = 167 bits (422), Expect = 3e-41
Identities = 135/502 (26%), Positives = 211/502 (42%), Gaps = 26/502 (5%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQ 82
Q ++ S+E G+ SS + S S E + N + SDS +E+ DD
Sbjct: 461 QGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAED----DDSD 516
Query: 83 YIYRLAGGFSRSTGKGGDDKDDDED------DSGDDTFGDDDSGPGPKDRQEGGNSRLGS 136
S G G+D +D D DS D D + D + +S S
Sbjct: 517 STSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNS 576
Query: 137 DEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGG 196
DSD + S +S+ + +++ S D+ D DS + S+SE
Sbjct: 577 SSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDS 636
Query: 197 GSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGG 256
S +SS + S+ D SD S NS +S S +S +S+ +N+ DS
Sbjct: 637 DSKSDSSDSNSSDSSDNSDSSDS-----SNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSD 691
Query: 257 SQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDS--- 313
S + S S S + D S+ D++ SDS+ +S+S D+ S DS
Sbjct: 692 SSDSSNSSES--SDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDS 749
Query: 314 --KGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPT 371
DS + S + S + S + D SS+SS +N S +SS S + S + D+ + +
Sbjct: 750 SNSSDSSDSSDSSNSSDSSDSSD--SSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSS 807
Query: 372 -TSYVEDQEDSDSS-EEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSS 429
+S D DSDSS DSS++ S S + + +DS S + S+ S S +S S
Sbjct: 808 DSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDS 867
Query: 430 QEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESR 489
+ S +SS S S +S+ + SDS DSS S + +S S SS D + ES
Sbjct: 868 SDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESS 927
Query: 490 KLTVDAYHNKPIGDQDDNDCQD 511
+ ++ + D +D D
Sbjct: 928 NSSDNSNSSDSSNSSDSSDSSD 949
Score = 165 bits (418), Expect = 8e-41
Identities = 132/505 (26%), Positives = 216/505 (42%), Gaps = 30/505 (5%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQY 83
N++ DS ++ Q P SS+ S G+ ++ E N S S S D+
Sbjct: 446 NSDGYDSYDFDDKSMQGDDP--NSSDESNGNDDANSESDNNSSSRGDASYNSDESKDN-- 501
Query: 84 IYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRL-GSDEDSDD 142
G S S G DD D D + D+ G+ ++G D+ + G + SD DS D
Sbjct: 502 -----GNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSD 556
Query: 143 TIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKP-EGGDSTQESESEEHWVGG----G 197
+ +S+ S DS+ +S + + D DS + DS+ S+S +
Sbjct: 557 SSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDS 616
Query: 198 SDGESSHGDGSELDDEGMQSDDP-ESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGG 256
SD S D S+ + + SD +S S +S NS S S +S+ +++ DS
Sbjct: 617 SDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSD 676
Query: 257 SQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGD 316
S S + D +++ + SDS+++SNS + D
Sbjct: 677 SSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSD 736
Query: 317 SQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVE 376
S S + S + S + D SS+SS +N S +SS+S + S + D+ D + S
Sbjct: 737 SSNSSDSSDSSDSSNSSD--SSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNS--S 792
Query: 377 DQEDSDSSEE--------DSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSS 428
D DS +S + DSS + S S + S+SS+S N S+ S S + S
Sbjct: 793 DSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSD 852
Query: 429 SQEGLQSHS--SSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEI 486
S +S S SS S S +S + D SDS DS+ S S+S++S +SS+ D +
Sbjct: 853 SDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSS 912
Query: 487 ESRKLTVDAYHNKPIGDQDDNDCQD 511
+S + + ++ D+++ D
Sbjct: 913 DSSDSSNSSDSSESSNSSDNSNSSD 937
Score = 165 bits (417), Expect = 1e-40
Identities = 128/501 (25%), Positives = 208/501 (41%), Gaps = 26/501 (5%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQY 83
++ DS + + + +SS+S+ S S + + D SDS S+ SD
Sbjct: 548 DSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDS 607
Query: 84 IYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSD------ 137
S + D E DS D D S D + +S S+
Sbjct: 608 SDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSD 667
Query: 138 ----EDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHW 193
DS D+ +S+ S + D+++ S D+ D DS + S S +
Sbjct: 668 SSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSD 727
Query: 194 VGGGSDG--ESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANT 251
SD S+ D S+ D SD +S S+ NS +S S +S ++S +++
Sbjct: 728 SSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS--SDSSNSSDSSDSSDSSDSSDSSNSSDS 785
Query: 252 QDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRR 311
DS S S S S+ D S+ D+++ SDS+ +S+S D+ S
Sbjct: 786 NDSSNSSDSSDSSNS-SDSSNSSDSSDSSDSSDSDSSN--SSDSSNSSDSSDSSNSSDSS 842
Query: 312 DSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPT 371
DS S ++ ++ +S N SS+SS ++ S+ +SS+S + S + D+ D +
Sbjct: 843 DSSDSSDGSDSDSSNRSDSSN----SSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSS 898
Query: 372 TSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSE-----ESPESPEDEN 426
S D DS +S + S + S SES +S SS+S N S+ +S S + N
Sbjct: 899 NSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSN 958
Query: 427 SSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEI 486
SS S S S S +S + D SDS DSS S + S+S+ S SS+ +
Sbjct: 959 SSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNS 1018
Query: 487 ESRKLTVDAYHNKPIGDQDDN 507
+ D+ ++ D D+
Sbjct: 1019 SDSSNSSDSSNSSDSSDSSDS 1039
Score = 164 bits (416), Expect = 1e-40
Identities = 136/511 (26%), Positives = 218/511 (42%), Gaps = 33/511 (6%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGL------- 76
N+ES+++ +G + S ES + S + A +D SDST
Sbjct: 478 NSESDNNSSSRGDASY------NSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGN 531
Query: 77 -GSDDHQYIYRLAGGFSRSTGKGGD-----DKDDDEDDSGDDTFGDDDSGPGPKDRQEGG 130
G+DD+ G S D D D D D+ DS D +
Sbjct: 532 NGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSS 591
Query: 131 NSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESR--ELDNEDRVDSKPEGGDS--TQE 186
+S +S D+ +S+ S + D+ S+S E D+ D DSK + DS +
Sbjct: 592 DSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDS-DSKSDSSDSNSSDS 650
Query: 187 SESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENS 246
S++ + S S D S+ D SD S S + NS+ +S
Sbjct: 651 SDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDS 710
Query: 247 EQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGL 306
+ +++ DS S + S S S D S+ D++ + SDS+++SNS D+
Sbjct: 711 DSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSD-SSDSSDSSNSSDSSD 769
Query: 307 SQPRRDSKGDSQEDSKENLSQEESQNVDGP-SSESSQEANLSSQENSSESQEEVVSESRG 365
S DS DS S N S S + D SS+SS ++ S +SS+S S+S
Sbjct: 770 SSDSSDSS-DSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSN 828
Query: 366 DNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDE 425
+ +S D DS S D S + S ++S+S S+SS+S N S+ S S +E
Sbjct: 829 SSDSSDSSNSSDSSDSSDSS-DGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNE 887
Query: 426 NSSSQEGLQSHSSSAESQSEESHSEE--DDSDSQD---SSRSKEDSNSTESKSSSEEDGQ 480
+S+S + S +SS S+ S+S + D S+S D SS S ++SNS++S +SS+
Sbjct: 888 SSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDS 947
Query: 481 LKNIEIESRKLTVDAYHNKPIGDQDDNDCQD 511
+ + D+ ++ D + +D D
Sbjct: 948 SDSSNSSDSSNSSDSSNSSDSSDSNSSDSSD 978
Score = 154 bits (390), Expect = 1e-37
Identities = 117/475 (24%), Positives = 206/475 (43%), Gaps = 20/475 (4%)
Query: 47 SSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDE 106
S +S+G + + D S+E G+DD A S + D +
Sbjct: 443 SDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDD-------ANSESDNNSSSRGDASYNS 495
Query: 107 DDSGDDTFGDDDSGPGPKDRQE----GGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTT 162
D+S D+ G D G D + G+ + +D S+ + S D++
Sbjct: 496 DESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSS 555
Query: 163 SESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPES 222
S D+ D DS +S+ +S+S + SD +SS D S D SD +S
Sbjct: 556 DSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSS--DSSNSSDSSDSSDSSDS 613
Query: 223 IRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEH-PSRKIFRKSRISEEDDRSE 281
S + + + +S ++ ++++ DS S ++ S S S+ D S+
Sbjct: 614 SDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSD 673
Query: 282 LDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESS 341
D+++ + S+S+++S+S D+ S DS S DS ++ S + D SS SS
Sbjct: 674 SSDSSSSSD-SSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSS 732
Query: 342 QEANLSSQENSSESQEEVVSESRGDNPDPT-TSYVEDQEDSDSSEEDSSHTLSHSKSESR 400
++ S+ +SS+S + S D+ D + +S D DS S + S+ + S+ S S
Sbjct: 733 DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSS 792
Query: 401 EEQADSESSESLNFSE--ESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSD--S 456
+ S SS+S N S+ +S +S + ++S+S + S SS S S +S D SD
Sbjct: 793 DSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSD 852
Query: 457 QDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQD 511
DSS + SNS++S SS+ + + + ++ + + D+D D
Sbjct: 853 SDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSD 907
Score = 154 bits (390), Expect = 1e-37
Identities = 126/461 (27%), Positives = 200/461 (43%), Gaps = 28/461 (6%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQY 83
+N S+ S+ + + +S+ESS S S + +N SDS+ S S D
Sbjct: 862 SNSSDSSDSSDSSNSSDSSDSSDSNESSNSS--DSSDSSNSSDSDSSDSSNSSDSSDSSN 919
Query: 84 IYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQ-EGGNSRLGSDEDSDD 142
+ S S+ + D +S D + D S + NS SD +S D
Sbjct: 920 ----SSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSD 975
Query: 143 TIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGES 202
+ +S S + D++ S ++ D DS DS+ S S + S S
Sbjct: 976 SSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSS----DSSDSSNSSDSSNSSDSSNSS 1031
Query: 203 SHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEH 262
D S+ D SD +S S+ NS +S S +S ++S+ +++ DS S
Sbjct: 1032 DSSDSSDSSDSSDSSDSSDS--SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESS---- 1085
Query: 263 PSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSK 322
S S S+ D S+ D++ + SDS+++SNS D+ S DS DS S
Sbjct: 1086 DSSDSSNSSDSSDSSDSSDSSDSSDSSD-SSDSSDSSNSSDSSDSSDSSDS-SDSSNSSD 1143
Query: 323 ENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSD 382
+ S E S + D SS+SS ++ S +SS+S + S D+ D + S D DS
Sbjct: 1144 SSDSSESSDSSD--SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS--SDSSDSS 1199
Query: 383 SSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAES 442
S + S + S S+S + S+SS+S + +E S S ++S S S+SS +
Sbjct: 1200 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDS-----SNSSDSSD 1254
Query: 443 QSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKN 483
S+ S S D +D DS + N+ S S S+ +G N
Sbjct: 1255 SSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSN 1295
Score = 151 bits (381), Expect = 2e-36
Identities = 127/441 (28%), Positives = 200/441 (45%), Gaps = 49/441 (11%)
Query: 49 ESSEGSKVSSEEQANEDPSDSTQS----EEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDD 104
+S G+KV ++ SD S ++ + DD S G DD +
Sbjct: 429 KSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPN---------SSDESNGNDDANS 479
Query: 105 DEDDS----GDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQD 160
+ D++ GD ++ D+S KD G +S+ D+DSD T S DS +
Sbjct: 480 ESDNNSSSRGDASYNSDES----KDNGNGSDSKGAEDDDSDST------SDTNNSDSNGN 529
Query: 161 TTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDP 220
+ + + D D K + DS S SD +SS + S D + SD
Sbjct: 530 GNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSS-DSDSSDSDSS 588
Query: 221 ESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRS 280
+S S+ +S +S S +S ++S+ +++ DS S +S S+ D +S
Sbjct: 589 DSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS--------KSDSSKSESDSSDSDSKS 640
Query: 281 ELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSES 340
+ D+N+ SDS++NS+S D+ S DS S DS ++ S +S N SS+S
Sbjct: 641 DSSDSNS-----SDSSDNSDSSDSSNSSNSSDSSDSS--DSSDSSSSSDSSN-SSDSSDS 692
Query: 341 SQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESR 400
S +N S +SS+S + S+S D+ + +S + SDSS+ +S S S S+S
Sbjct: 693 SDSSNSSESSDSSDSSDSDSSDS-SDSSNSNSSDSDSSNSSDSSDSSNSSDSSDS-SDSS 750
Query: 401 EEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDS---DSQ 457
S+SS+S N S+ S S ++S S S+ SS S S +S + D S DS
Sbjct: 751 NSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSS 810
Query: 458 DSSRSKEDSNSTESKSSSEED 478
DSS S + +S S SS+ D
Sbjct: 811 DSSDSSDSDSSNSSDSSNSSD 831
Score = 150 bits (379), Expect = 3e-36
Identities = 136/547 (24%), Positives = 230/547 (42%), Gaps = 68/547 (12%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEE----GLGSD 79
+NE + + K A P S+ E ++ + ++ + T+ E G D
Sbjct: 314 HNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQD 373
Query: 80 DHQYIYRLAGG---FSRSTGKGGDDKDDDEDDS------GDDTFGDDDSGPGPKDRQEGG 130
I + G ++ GKG + K+D T G+ + GP + E G
Sbjct: 374 KGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPG 433
Query: 131 N----SRLGSDEDSD--DTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDST 184
N S GSD +SD D+ ++S ++ D ++ + + ++E +S G S
Sbjct: 434 NKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASY 493
Query: 185 QESESEEHWVGGGSDGESSHGDGSELDDEGMQSD--------DPESIRSERGNSRMNSAG 236
ES+++ G GSD + + D S+ + SD + ++ +S+ G + +S+
Sbjct: 494 NSDESKDN--GNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSD 551
Query: 237 MKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDST 296
S +S +S+ +++ DS S S S+ D D +++ SDS+
Sbjct: 552 SDSSDSSNSSDSSDSSDSDSSDSNSSSD------SDSSDSDSSDSSDSDSSDSSNSSDSS 605
Query: 297 ENSNSRDTGLSQPRRDSK------------GDSQEDSKENLSQEESQNVD---------- 334
++S+S D+ S DSK DS+ DS ++ S + S N D
Sbjct: 606 DSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNS 665
Query: 335 ---------GPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSE 385
SS SS +N S +SS+S S D+ D +S D +S+SS+
Sbjct: 666 SDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSD 725
Query: 386 EDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSE 445
DSS+ S S+S S+SS+S N S+ S S +S S + S SS S S
Sbjct: 726 SDSSN--SSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 783
Query: 446 ESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQD 505
+S+ + SDS DSS S + SNS++S SS+ + +S + + + D
Sbjct: 784 DSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSD 843
Query: 506 DNDCQDG 512
+D DG
Sbjct: 844 SSDSSDG 850
Score = 150 bits (378), Expect = 3e-36
Identities = 118/450 (26%), Positives = 199/450 (44%), Gaps = 40/450 (8%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQY 83
+NES +S + + + +SS SS+ SS+ + D S+S+ S + S D
Sbjct: 885 SNESSNSSDSSDSSNSSDSDSSDSSNSSD----SSDSSNSSDSSESSNSSDNSNSSD--- 937
Query: 84 IYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDE-DSDD 142
+ S S+ D +S D + D S D + NS SD DS D
Sbjct: 938 ----SSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSD 993
Query: 143 TIQASEESAPQGQDSAQDTTSESRELDNEDRVDSK--PEGGDSTQESESEEHWVGGGSDG 200
+ +S+ S + D++ S D+ + DS + DS+ S+S + S
Sbjct: 994 SSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD 1053
Query: 201 ESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLL 260
S+ D S+ D SD +S S+ +S +S S S ++S+ +++ DS S
Sbjct: 1054 SSNSSDSSDSSDSSDSSDSSDS--SDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDS--- 1108
Query: 261 EHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQED 320
S+ D S+ D++ SDS+++S+S D+ S DS DS E
Sbjct: 1109 -------------SDSSDSSDSSDSSN----SSDSSDSSDSSDSSDSSNSSDS-SDSSES 1150
Query: 321 SKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPT-TSYVEDQE 379
S + S + S + D SS+SS ++ S NSS+S + S D+ D + +S D
Sbjct: 1151 SDSSDSSDSSDSSD--SSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1208
Query: 380 DSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSS 439
DS S + S + S S+S + S+SS+S + S+ S S ++S S + +
Sbjct: 1209 DSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDE 1268
Query: 440 AESQSEESHSEEDDSDSQDSSRSKEDSNST 469
++SQS+ + + SDS S + ++ST
Sbjct: 1269 SDSQSKSGNGNNNGSDSDSDSEGSDSNHST 1298
Score = 106 bits (264), Expect = 6e-23
Identities = 122/535 (22%), Positives = 206/535 (38%), Gaps = 77/535 (14%)
Query: 25 NESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYI 84
NE + E W G +A T + E + ++ Q D+
Sbjct: 101 NEEGNIEGWNGDTGKAETYGHDGIHGKEENITANGIQGQVSIIDN--------------- 145
Query: 85 YRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTI 144
AG +RS G DK+ D GD +D + QE G GS+ +D+
Sbjct: 146 ---AGATNRSNTNGNTDKNTQNGDVGDAGHNEDVAVV-----QEDGPQVAGSNNSTDNED 197
Query: 145 QASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSH 204
+ E S ++++ T + + + + P G+ S+ G G+D +
Sbjct: 198 EIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGADEDEDE 257
Query: 205 GDGSELDDE-----------------------------GMQSDDPESIRSERGNSRMNSA 235
G G + D+E G SD E E N
Sbjct: 258 GSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEV 317
Query: 236 -GMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKS-----RISEEDDRSELDDNNTME 289
G K+ +S ENS A + GSQ +E + R+S RI++E + + +
Sbjct: 318 DGDKTSKSEENS--AGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKG 375
Query: 290 -EVKSDSTENSN-SRDTGLSQPRRDSKGD-SQEDSKENL-SQEESQNVDGPSSESSQ--- 342
E+K S+ N N +++ G ++ KG K N+ +Q E N++GP +S
Sbjct: 376 IEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNK 435
Query: 343 --EANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESR 400
+N S NS + DP +S + D +SE D++ + S +
Sbjct: 436 VGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNS 495
Query: 401 EEQADS-ESSESLNFSEESPESPEDENSSSQ--EGLQSHSSSAESQSEESHSEEDDSDSQ 457
+E D+ S+S ++ +S D N+S G + + +S S + S+ DSDS
Sbjct: 496 DESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSS 555
Query: 458 DSSRSKE-----DSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDN 507
DSS S + DS+S++S SSS+ D + S + D+ ++ D D+
Sbjct: 556 DSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDS 610
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 103 bits (256), Expect = 5e-22
Identities = 99/486 (20%), Positives = 192/486 (39%), Gaps = 55/486 (11%)
Query: 46 ESSESSEGSKVSSEE-QANEDP---SDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGD- 100
E +E S+G+ + +E +ANE+ + + + SDD ++ G ++S G+ D
Sbjct: 591 EGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDG 650
Query: 101 -----DKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQ 155
D +E SG + + D++ G KD+ G R G E + +E+ + +
Sbjct: 651 PEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEK-----ELAEKEEWKKR 705
Query: 156 DSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGM 215
D + E + ++R EGG+ EEH G G + E + E + EG
Sbjct: 706 DGEEQEQKEREQGHQKERNQEMEEGGE-------EEH--GEGEEEEGDREEEEEKEGEGK 756
Query: 216 QSDDPESIRSERGNSRMNSAGMKSKESGENS--EQANTQDSGGSQLLEHPSRKIFRKSRI 273
+ + E + ER KE GE E+A ++ G + + + + R
Sbjct: 757 EEGEGEEVEGER-----------EKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRG 805
Query: 274 SEEDDRSELDDNNTME---EVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEES 330
E+++ E++ E E + + E + G + + +G+ +E+ E +EE
Sbjct: 806 EEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE---EEEGEGEEEEGEGKGEEEG 862
Query: 331 QNVDGPSSESSQEANLSSQENSSESQEE-----VVSESRGDNPDPTTSYVEDQEDSDSSE 385
+ +G E +E E +EE E G+ + E++E E
Sbjct: 863 EEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGE 922
Query: 386 EDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSE 445
E+ + E EE+ + E + EE E E +EG E + E
Sbjct: 923 EEG----EEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGE---EEEGEGEGEEEGEGEGE 975
Query: 446 ESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQD 505
E E ++ + + +E E + EE+G+ + E E ++ + + G+ +
Sbjct: 976 EGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGE 1035
Query: 506 DNDCQD 511
+ + ++
Sbjct: 1036 EEEGEE 1041
Score = 93.6 bits (231), Expect = 4e-19
Identities = 96/470 (20%), Positives = 175/470 (37%), Gaps = 73/470 (15%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQ 82
+ E + ++ +G + + E +E E K EEQ ++ Q E ++
Sbjct: 672 EEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEE-- 729
Query: 83 YIYRLAGGFSRSTGKG----GDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDE 138
G G+G GD ++++E + G+ + G ++++EG + E
Sbjct: 730 -------GGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKK----E 778
Query: 139 DSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDS-KPEGGDSTQESESEEHWVGGG 197
+ + EE QG+ ++T E + V+ + E G +E E EE
Sbjct: 779 ERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEE------ 832
Query: 198 SDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGS 257
+GE G+G E + EG + ++ E E G + +E GE E ++ G
Sbjct: 833 GEGEEEEGEGEEEEGEG-EEEEGEGKGEEEGEEG------EGEEEGEEGEGEGEEEEGEG 885
Query: 258 QLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDS 317
+ EE+ E ++ EE + + E + + KG+
Sbjct: 886 E---------------GEEEGEGEGEE----EEGEGEGEEEGEGEG---EEEEGEGKGEE 923
Query: 318 QEDSKENLSQEES---QNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSY 374
+ + E +EE + DG +E +E E + E E G+ +
Sbjct: 924 EGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEG-- 981
Query: 375 VEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 434
E++E EE+ + E EE E E E E E E EG +
Sbjct: 982 -EEEEGEGEGEEE------EGEEEGEEEGEGEEEGEG-----EGEEEEEGEVEGEVEGEE 1029
Query: 435 SHSSSAESQSEESHSE-EDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKN 483
E + EE E E + + +++ R++E+ E K +E G+ +N
Sbjct: 1030 GEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGK--YQETGEEEN 1077
Score = 81.6 bits (200), Expect = 2e-15
Identities = 78/369 (21%), Positives = 134/369 (36%), Gaps = 53/369 (14%)
Query: 140 SDDTIQASEESAPQGQDSAQDTTSESRELD-NEDRVDSKPEGG-------------DSTQ 185
SD+ ++ EE +G + ++ E +E++ NE+ V K GG D +
Sbjct: 580 SDEEVEIPEEK--EGAEDSKGNGIEEQEVEANEENV--KVHGGRKEKTEILSDDLTDKAE 635
Query: 186 ESESEEHWVGGGSDGESSHGDGS----ELDDEGMQSDDPESIRSERGNSRMNSAGMKSKE 241
SE + VG DG GDG+ E Q ++ E ++G M G KE
Sbjct: 636 VSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKE 695
Query: 242 SGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNS 301
E E K R EE ++ E + + E ++ E
Sbjct: 696 LAEKEEW---------------------KKRDGEEQEQKEREQGHQKE--RNQEMEEGGE 732
Query: 302 RDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVS 361
+ G + + + +E E + E + V+G + E + E EE
Sbjct: 733 EEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGD 792
Query: 362 ESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESP-- 419
+ G+ + T E++E+ E + K E EE+ + E E EE
Sbjct: 793 QGEGEEEE-TEGRGEEKEEGGEVEGGE---VEEGKGEREEEEEEGEGEEEEGEGEEEEGE 848
Query: 420 -ESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEED 478
E E E +EG + E + E EE++ + + + + E + EE+
Sbjct: 849 GEEEEGEGKGEEEGEEGEGEE-EGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEE 907
Query: 479 GQLKNIEIE 487
G+ + E E
Sbjct: 908 GEGEGEEEE 916
Score = 77.0 bits (188), Expect = 4e-14
Identities = 70/352 (19%), Positives = 130/352 (36%), Gaps = 16/352 (4%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQ 82
+ E E EE +G + E E E+ E + EE G + +
Sbjct: 749 EEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEK 808
Query: 83 YIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTF-GDDDSGPGPKDRQEG-----GNSRLGS 136
G GKG +++++E + ++ G+++ G G ++ EG G G
Sbjct: 809 EEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGE 868
Query: 137 DEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGG 196
+E + + EE + + E E + E + + EG + E + EE G
Sbjct: 869 EEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEG 928
Query: 197 GSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGG 256
+GE G+G D EG ++ E + + GE E ++ G
Sbjct: 929 EGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGE-GEGEEEGEGEGEEGEGEGEEEEGE 987
Query: 257 SQLLEHPSRKIFRKSRISEEDDRSELDDNNTME---EVKSDSTENSNSRDTGLSQPRRDS 313
+ E + + EE+ E ++ E EV+ + E + G +
Sbjct: 988 GEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEERE 1047
Query: 314 KGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRG 365
K E+++ N +EE + +G E+ +E N E + + VS+ +G
Sbjct: 1048 KEGEGEENRRNREEEEEE--EGKYQETGEEEN----ERQDGEEYKKVSKIKG 1093
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 98.6 bits (244), Expect = 1e-20
Identities = 106/433 (24%), Positives = 171/433 (39%), Gaps = 42/433 (9%)
Query: 99 GDDKDD-------DEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESA 151
GD DD DE DSG D G+DD G R +E SD E+
Sbjct: 8 GDQSDDGGATPVQDERDSGSD--GEDDVNEQHSGSDTGSVERHSENETSD-----REDGL 60
Query: 152 PQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESS----HGDG 207
P+G E L+ D +S+ +SESEE SD E+ HG
Sbjct: 61 PKGHHVTDSENDEPLNLNASDS-ESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSD 119
Query: 208 SELDDE----GMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHP 263
SE ++ G S++ E + +S G K +SE Q S S
Sbjct: 120 SESEETRKLPGSDSENEELLNGHASDSENEDVG---KHPASDSEIEELQKSPASDSETED 176
Query: 264 SRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKE 323
+ K SEE R + D+ E K S+S L +P+ S +S+E +
Sbjct: 177 ALKPQISDSESEEPPRHQASDSENEEPPKP---RMSDSESEELPKPQV-SDSESEEPPRH 232
Query: 324 NLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSE--SRGDNPDPTTSYVEDQEDS 381
S E++ + P S+ + + S EE+ S ++ DP + D E
Sbjct: 233 QASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSE-- 290
Query: 382 DSSEEDSSHTLSHSKSESREEQADSES-SESLNFSEESPESPED---ENSSSQEGLQSHS 437
+EE +S S+SE ++ S+S +E + ++ PES +D EN +Q+ S
Sbjct: 291 --NEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDS 348
Query: 438 SSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESR--KLTVDA 495
++S + DS+ ++ + K DS+ E + E+ + K + + A
Sbjct: 349 FHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASA 408
Query: 496 YHNKPIGDQDDND 508
++ + D DD+D
Sbjct: 409 KKSRVVSDADDSD 421
Score = 82.4 bits (202), Expect = 9e-16
Identities = 115/496 (23%), Positives = 181/496 (36%), Gaps = 64/496 (12%)
Query: 19 VTRYQNNESEDSEEW--KGHLA--QAPTPPLE----SSESSE-----GSKVSSEEQANED 65
V R+ NE+ D E+ KGH PL SES E S SEE+A
Sbjct: 45 VERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPP 104
Query: 66 PSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGK-GGDDKDDDEDDSG---DDTFGDDDSGP 121
SDS + D + S T K G D +++E +G D D P
Sbjct: 105 ASDSENEDVNQHGSDSE---------SEETRKLPGSDSENEELLNGHASDSENEDVGKHP 155
Query: 122 GPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGG 181
E SD +++D ++ PQ DS + + D+E+ KP
Sbjct: 156 ASDSEIEELQKSPASDSETEDALK------PQISDSESEEPPRHQASDSENEEPPKPRMS 209
Query: 182 DSTQE---------SESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRM 232
DS E SESEE SD E+ + D +S+DP R + +S
Sbjct: 210 DSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDS--ESEDPP--RHQASDSE- 264
Query: 233 NSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVK 292
N K + S SE + S+ E P K R+S D SE + +
Sbjct: 265 NEELPKPRISDSESEDPPRNQASDSENEELP------KPRVS--DSESEGPQKGPASDSE 316
Query: 293 SDSTENSNSRDTGLSQPRRDSKGDSQEDSKENL-SQEESQNVDGPSSESSQEANLSSQEN 351
++ + R++KG+ E ++ S SS+S +E + + +
Sbjct: 317 TEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMD 376
Query: 352 SSESQEEVVSESRGDNPDPTTSYVEDQED---------SDSSEEDSSHTLSHSKSESREE 402
S E ++E E S ED+E SD+ + DS S +
Sbjct: 377 SDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTI 436
Query: 403 QADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRS 462
+DSE S++ E + S S+ G + + A+ E EE++ +
Sbjct: 437 ASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDL 496
Query: 463 KEDSNSTESKSSSEED 478
+E+ T+ K + + D
Sbjct: 497 EEEKGETQVKEAEDSD 512
Score = 66.2 bits (160), Expect = 7e-11
Identities = 85/380 (22%), Positives = 148/380 (38%), Gaps = 38/380 (10%)
Query: 19 VTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGS 78
+ Q + + DSE A P + SES E + + + NE+P S+ S
Sbjct: 161 IEELQKSPASDSET-----EDALKPQISDSESEEPPRHQASDSENEEPPKPRMSD----S 211
Query: 79 DDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDR-QEGGNSRLGSD 137
+ + D + ++ D +S P+ + + N L
Sbjct: 212 ESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKP 271
Query: 138 EDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGG 197
SD + E P+ Q S SE+ EL DS+ EG S+SE
Sbjct: 272 RISD----SESEDPPRNQAS----DSENEELPKPRVSDSESEGPQKGPASDSE------- 316
Query: 198 SDGESSHGDGSELDDEGMQSDDPESIR----SERGNSRMNSAGMKSKESGENSEQANTQD 253
++ S H E DD+ + + E S +S M+ S +S E + D
Sbjct: 317 TEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMD 376
Query: 254 SGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDS 313
S + E K+ ++ D E + V SD+ ++ + + S R +
Sbjct: 377 SDEDE-KEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKT 435
Query: 314 -KGDSQEDSKENLSQEESQNVD--GPSSES-SQEANLSSQ---ENSSESQEEVVSESRGD 366
DS+E++ + LS ++++ D G SES ++E NL + E+ E +EE ++ D
Sbjct: 436 IASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQED 495
Query: 367 -NPDPTTSYVEDQEDSDSSE 385
+ + V++ EDSDS +
Sbjct: 496 LEEEKGETQVKEAEDSDSDD 515
Score = 60.1 bits (144), Expect = 5e-09
Identities = 66/268 (24%), Positives = 112/268 (41%), Gaps = 27/268 (10%)
Query: 269 RKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQE 328
R S EDD +E + V+ S ++ R+ GL P+ DS+ D NL+
Sbjct: 23 RDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGL--PKGHHVTDSENDEPLNLNAS 80
Query: 329 ESQNVD-GPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYV--EDQED----- 380
+S++ + +S E+ ++ +S+S+ E V++ D+ T + D E+
Sbjct: 81 DSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLN 140
Query: 381 ---SDSSEED-SSHTLSHSKSESREEQ--ADSESSESLN---FSEESPESPEDENSSSQE 431
SDS ED H S S+ E ++ +DSE+ ++L ES E P + S S+
Sbjct: 141 GHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSEN 200
Query: 432 GLQSHSSSAESQSEE--------SHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKN 483
++S+SEE S SEE S ++E S S SE+ + +
Sbjct: 201 EEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQA 260
Query: 484 IEIESRKLTVDAYHNKPIGDQDDNDCQD 511
+ E+ +L + D N D
Sbjct: 261 SDSENEELPKPRISDSESEDPPRNQASD 288
Score = 54.3 bits (129), Expect = 3e-07
Identities = 74/325 (22%), Positives = 118/325 (36%), Gaps = 45/325 (13%)
Query: 21 RYQNNESEDSEEWKGHLAQAPT--PPLESSESSEGSKV--------SSEEQANEDPSDST 70
R+Q ++SE+ E K ++ + + PP + SE ++ SE+ SDS
Sbjct: 231 RHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSE 290
Query: 71 QSE---------EGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGP 121
E E G SR K D D D ++ G+DT +DS
Sbjct: 291 NEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFH 350
Query: 122 G----------PKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNE 171
D +E + + D D D+ E+ A + D+ E + +
Sbjct: 351 SDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKK 410
Query: 172 DRVDSKPEGGDS---TQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERG 228
RV S + DS + +S E + S+ E+ G EL D+ + D SE G
Sbjct: 411 SRVVSDADDSDSDAVSDKSGKREKTIASDSEEEA----GKELSDKKNEEKDLFGSDSESG 466
Query: 229 NSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSE------- 281
N N ESG+ E+ T L E +++ S+ DD +
Sbjct: 467 NEEENLIADIFGESGDEEEEEFT-GFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDF 525
Query: 282 -LDDNNTMEEVKSDSTENSNSRDTG 305
D ++ KS S + +RD G
Sbjct: 526 LSDFEMMLQRKKSMSGKRRRNRDGG 550
Score = 52.4 bits (124), Expect = 1e-06
Identities = 64/292 (21%), Positives = 114/292 (39%), Gaps = 64/292 (21%)
Query: 17 LPVTRYQNNESEDSEEWKGHLAQ---APTPPLESSESSEGSKVSSEEQANED-------P 66
LP R ++ESED + ++ P P + SES + + + + NE+
Sbjct: 242 LPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSD 301
Query: 67 SDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDS------- 119
S+S ++G SD SR K D D D ++ G+DT +DS
Sbjct: 302 SESEGPQKGPASDSE------TEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHM 355
Query: 120 -----GPGPKDRQEGGNSRLGSDED-------------------SDDTIQASEESA---P 152
+ +E ++ SDED S+D +AS + +
Sbjct: 356 DRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVS 415
Query: 153 QGQDSAQDTTSE-SRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSH------- 204
DS D S+ S + + DS+ E G + ++EE + GSD ES +
Sbjct: 416 DADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDL-FGSDSESGNEEENLIA 474
Query: 205 ---GDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQD 253
G+ + ++E + E + E+G +++ A + +S +N ++ D
Sbjct: 475 DIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEA--EDSDSDDNIKRGKHMD 524
>gi|60097902 filaggrin [Homo sapiens]
Length = 4061
Score = 91.7 bits (226), Expect = 1e-18
Identities = 122/546 (22%), Positives = 198/546 (36%), Gaps = 62/546 (11%)
Query: 20 TRYQNNESEDSEEWKGHLA----QAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEG 75
+R+ + ED GH A Q+ TP E+S S G SS EQA P + S
Sbjct: 982 SRHPRSHHED-RAGHGHSADSSRQSGTPHAETS--SGGQAASSHEQARSSPGERHGSRHQ 1038
Query: 76 LGSDDHQY----------IYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKD 125
+D ++ R +G + S + D + E+ G GP +
Sbjct: 1039 QSADSSRHSGIPRRQASSAVRDSGHWGSSGSQASDSEGHSEESDTQSVSGHGQDGPHQQS 1098
Query: 126 RQE------GGNS--------RLGSDEDSDDTIQASEESAPQGQDS----AQDTTSESRE 167
QE GG S ++ + E S+ + S + Q S A+D++ S
Sbjct: 1099 HQESARDWSGGRSGRSGSFIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSAS 1158
Query: 168 LDNEDRVDSKP---EGG----------DSTQESESEEHWVGGGSDGESSHGD-GSELDDE 213
+ +D + + P GG D + S S ++SHG GS
Sbjct: 1159 QEGQDTIRAHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASR 1218
Query: 214 GMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRI 273
+ D S SR + A + S + Q + S GS+ H + + S
Sbjct: 1219 QTRKDKQSGDGSRHSGSRHHEAASWADSSRHS--QVGQEQSSGSRTSRHQGSSVSQDSDS 1276
Query: 274 SEEDDRSELDDNNTMEEVKSDSTENSN--SRDTGLSQPRRDSKGDSQEDSKENLSQEESQ 331
D SE + S E S SR G Q R S G S + S+++ +
Sbjct: 1277 ERHSDDSERLSGSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSRQSGTHHTES 1336
Query: 332 NVDGPSSESSQEANLSSQENSSESQEEVVSESR--GDNPDPTTSYVEDQEDSDSSEEDSS 389
+ G + S ++A S E ++ SR G +S V D SS +
Sbjct: 1337 SSHGQAVSSHEQARSSPGERHGSRHQQSADSSRHSGIGHRQASSAVRDSGHRGSSGSQVT 1396
Query: 390 HTLSHSK-SESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESH 448
++ HS+ S+++ A ++ +ES E+S SS E QSE +H
Sbjct: 1397 NSEGHSEDSDTQSVSAHGQAGPHQQSHKESARGQSGESSGRSRSFLYQVSSHE-QSESTH 1455
Query: 449 SEEDDSDS-QDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDN 507
+ S + SR ++ NS+ +S + ++ SR +YH + + D
Sbjct: 1456 GQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSSRGGRQGSYHEQSV----DR 1511
Query: 508 DCQDGY 513
GY
Sbjct: 1512 SGHSGY 1517
Score = 83.2 bits (204), Expect = 5e-16
Identities = 102/448 (22%), Positives = 160/448 (35%), Gaps = 30/448 (6%)
Query: 52 EGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGD 111
+GS VS + + DS + E S +H Y A SR + +D G
Sbjct: 1590 QGSSVSQDRDSEGHSEDSERRSES-ASRNH---YGSAREQSRHGSRNPRSHQEDRASHGH 1645
Query: 112 DTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNE 171
SG + GG + ++ + Q DS+ D+ + R+ D+
Sbjct: 1646 SAESSRQSGTRHAETSSGGQAASSQEQARSSPGERHGSRHQQSADSSTDSGTGRRQ-DSS 1704
Query: 172 DRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSR 231
DS G +Q S+SE H + S+HG Q ES R + G
Sbjct: 1705 VVGDSGNRGSSGSQASDSEGHSEESDTQSVSAHGQAGP-----HQQSHQESTRGQSGERS 1759
Query: 232 MNSAG----MKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEE----------D 277
S + + E E++ +GG Q H + + S+E
Sbjct: 1760 GRSGSFLYQVSTHEQSESAHGRTGPSTGGRQRSRHEQARDSSRHSASQEGQDTIRGHPGS 1819
Query: 278 DRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRD-SKGDSQEDSKENLSQEESQNVDGP 336
R ++ + V S S+ T SQ R D S+G S S ++ E Q+ DG
Sbjct: 1820 SRGGRQGSHYEQSVDSSGHSGSHHSHT-TSQERSDVSRGQSGSRSVSRQTRNEKQSGDGS 1878
Query: 337 SSESSQEANLSSQENSSESQEEVVSESRGDNPDPTT-SYVEDQEDSDSSEEDS---SHTL 392
S+ SS+ +SS + +S G S V DS EDS S +
Sbjct: 1879 RHSGSRHHEASSRADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSA 1938
Query: 393 SHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEED 452
S + S EQ+ S + E+ +SS Q G + SS+ Q+ SH +
Sbjct: 1939 SRNHLGSAWEQSRDGSRHPGSHHEDRAGHGHSADSSRQSGTRHTESSSRGQAASSHEQAR 1998
Query: 453 DSDSQDSSRSKEDSNSTESKSSSEEDGQ 480
S + + ++ S+ S GQ
Sbjct: 1999 SSAGERHGSHHQLQSADSSRHSGIGHGQ 2026
Score = 78.6 bits (192), Expect = 1e-14
Identities = 107/482 (22%), Positives = 171/482 (35%), Gaps = 37/482 (7%)
Query: 27 SEDSEEWKGHLAQ------------APTPPLESSESSEGSKVSSEEQANEDPSDSTQSEE 74
SEDSE W G ++ P E G S++ + S
Sbjct: 631 SEDSERWSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSADSSRKSGTRHTQNSSS 690
Query: 75 GLGSDDHQYIYRLAGGF--SRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNS 132
G + H+ AG SR + D G + DSG + +S
Sbjct: 691 GQAASSHEQARSSAGERHGSRHQLQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDS 750
Query: 133 RLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEH 192
G EDSD + A Q S Q++ + R + R S + ++SES
Sbjct: 751 E-GHSEDSDTQSVSGHGQAGHHQQSHQESARD-RSGERSRRSGSFLYQVSTHKQSESSHG 808
Query: 193 WVGG--GSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGM-------KSKESG 243
W G G S H + D ++IR G+SR G +S SG
Sbjct: 809 WTGPSTGVRQGSHHEQARDNSRHSASQDGQDTIRGHPGSSRRGRQGSHHEQSVDRSGHSG 868
Query: 244 ENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSR- 302
+ +Q + + SR R +R E+ + E S + + +S+
Sbjct: 869 SHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSRDGSRHSGSRHHEASSHADISRHSQA 928
Query: 303 DTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSE 362
G S+ R S+ S+++ S+ S++ + S +S+ S+QE S S
Sbjct: 929 GQGQSEGSRTSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSAQEQSRHGSRHPRSH 988
Query: 363 -----SRGDNPDPTT-SYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSE 416
G + D + S E S + SSH + S R +S++S S
Sbjct: 989 HEDRAGHGHSADSSRQSGTPHAETSSGGQAASSHEQARSSPGERHGSRHQQSADS---SR 1045
Query: 417 ESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSE 476
S +S+ ++ SS +++ E HSEE SD+Q S +D +S S
Sbjct: 1046 HSGIPRRQASSAVRDSGHWGSSGSQASDSEGHSEE--SDTQSVSGHGQDGPHQQSHQESA 1103
Query: 477 ED 478
D
Sbjct: 1104 RD 1105
Score = 78.2 bits (191), Expect = 2e-14
Identities = 121/553 (21%), Positives = 207/553 (37%), Gaps = 116/553 (20%)
Query: 22 YQNNESEDSEEWKG--------HLAQAPTPPLESSESSEG-SKVSSEEQANEDPSDSTQS 72
+Q + E + +W G + Q T E SES+ G ++ S+ + + S
Sbjct: 1095 HQQSHQESARDWSGGRSGRSGSFIYQVSTH--EQSESAHGRTRTSTGRRQGSHHEQARDS 1152
Query: 73 EEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDD--------TFGDDDSGPGP- 123
S + Q R G SR G+ G + D SG + G D+ G
Sbjct: 1153 SRHSASQEGQDTIRAHPG-SRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASHGQS 1211
Query: 124 ----------KDRQEGGNSR--------LGSDEDSDDTIQASEE-------SAPQGQDSA 158
KD+Q G SR S DS Q +E S QG +
Sbjct: 1212 GSRSASRQTRKDKQSGDGSRHSGSRHHEAASWADSSRHSQVGQEQSSGSRTSRHQGSSVS 1271
Query: 159 QDTTSESRELDNEDRVD---SKPEGGDSTQESESEEHWVGGGSDGESSHGDGS------- 208
QD+ SE R D+ +R+ S+ G S ++S G + +SHG +
Sbjct: 1272 QDSDSE-RHSDDSERLSGSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSRQSG 1330
Query: 209 ----ELDDEGMQSDDPESIRS---ERGNSRMNSAGMKSKESGENSEQANT--QDSGGSQL 259
E G E RS ER SR + S+ SG QA++ +DSG
Sbjct: 1331 THHTESSSHGQAVSSHEQARSSPGERHGSRHQQSADSSRHSGIGHRQASSAVRDSG---- 1386
Query: 260 LEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQE 319
+ S+++ + SE D ++ + +++ Q +S G S+
Sbjct: 1387 -----HRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHKESARGQSG-ESSGRSRS 1440
Query: 320 DSKENLSQEESQNVDGPSSESS--------QEANLSSQENSSESQEEVV----SESRGDN 367
+ S E+S++ G ++ S+ ++A SS+ ++S+ ++ + SRG
Sbjct: 1441 FLYQVSSHEQSESTHGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSSRGGR 1500
Query: 368 PDPTTSYVEDQED------------SDSSEEDSSHTLSHSKSESREEQADSESSESLNFS 415
SY E D + D+SH S +S SR+ + + +S + S
Sbjct: 1501 QG---SYHEQSVDRSGHSGYHHSHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGSRHS 1557
Query: 416 EESPESP-------------EDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRS 462
P + E++ S+ + SS ++ + E HSE+ + S+ +SR+
Sbjct: 1558 GSRHHEPSTRAGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRN 1617
Query: 463 KEDSNSTESKSSS 475
S +S+ S
Sbjct: 1618 HYGSAREQSRHGS 1630
Score = 77.0 bits (188), Expect = 4e-14
Identities = 114/493 (23%), Positives = 178/493 (36%), Gaps = 47/493 (9%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQA------NEDPSDSTQSEEGL 76
Q + + S + H ++SS S+V E+ + ++ S S S+
Sbjct: 1219 QTRKDKQSGDGSRHSGSRHHEAASWADSSRHSQVGQEQSSGSRTSRHQGSSVSQDSDSER 1278
Query: 77 GSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGP----GPKDRQEGGNS 132
SDD + RL+G SR+ G ++ D S F +D RQ G +
Sbjct: 1279 HSDDSE---RLSGSASRN--HHGSSREQSRDGSRHPGFHQEDRASHGHSADSSRQSGTHH 1333
Query: 133 RLGSDEDSDDTIQASEESAP---------QGQDSAQDTTSESRELDNEDRVDSKPEGGDS 183
S + S+P Q DS++ + R+ + R DS G
Sbjct: 1334 TESSSHGQAVSSHEQARSSPGERHGSRHQQSADSSRHSGIGHRQASSAVR-DSGHRGSSG 1392
Query: 184 TQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESG 243
+Q + SE H + S+HG +S +S S G SR + S E
Sbjct: 1393 SQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHKESARGQSGESS-GRSRSFLYQVSSHEQS 1451
Query: 244 ENSEQANTQDSGGSQLLEHP-SRKIFRKSRISEEDDR-------SELDDNNTMEEVKSDS 295
E++ +GG Q H +R R S + D S + E D
Sbjct: 1452 ESTHGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSSRGGRQGSYHEQSVDR 1511
Query: 296 TENSNSRDTGLS-QPRRD-SKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSS 353
+ +S + + Q R D S G S S ++ E Q+ DG S+ S++ SS
Sbjct: 1512 SGHSGYHHSHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGSRHSGSRHHEPSTRAGSS 1571
Query: 354 ESQEEVVSESRGDNPDPTT-SYVEDQEDSDSSEEDS---SHTLSHSKSESREEQADSESS 409
+ ES G S V DS+ EDS S + S + S EQ+ S
Sbjct: 1572 RHSQVGQGESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYGSAREQSRHGSR 1631
Query: 410 ESLNFSEESPESPEDENSSSQEGLQ-------SHSSSAESQSEESHSEEDDSDSQDSSRS 462
+ E+ SS Q G + ++S++ Q+ S E S Q S+ S
Sbjct: 1632 NPRSHQEDRASHGHSAESSRQSGTRHAETSSGGQAASSQEQARSSPGERHGSRHQQSADS 1691
Query: 463 KEDSNSTESKSSS 475
DS + + SS
Sbjct: 1692 STDSGTGRRQDSS 1704
Score = 76.6 bits (187), Expect = 5e-14
Identities = 104/456 (22%), Positives = 171/456 (37%), Gaps = 55/456 (12%)
Query: 50 SSEGSKVSSEEQANEDPSD--STQSEEGLGSDDHQYIYR----LAGGFSRSTGKGGDDKD 103
SS G SS EQA P + ++ ++ S H I R A SR G G
Sbjct: 3282 SSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRGQASSAVRDSRHWGSSGSQAS 3341
Query: 104 DDEDDSGDD----TFGDDDSGPGPKDRQEGGNSRLG--SDEDSDDTIQASEESAPQGQDS 157
D E S + G +GP + QE R G S Q S +
Sbjct: 3342 DSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHEQSESAHG 3401
Query: 158 AQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQS 217
T++ R+ + + + DS++ S S+E G D H
Sbjct: 3402 RTRTSTGRRQGSHHE------QARDSSRHSASQE-----GQDTIRGH------------- 3437
Query: 218 DDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEE- 276
P S R R S + +S SG + +Q + + SR R++R E+
Sbjct: 3438 --PGSSRRGRQGSHYEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRQTRNDEQS 3495
Query: 277 -DDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDG 335
D ++ ++DS+ +S S G S R S+ S+++ SQ S++ +
Sbjct: 3496 GDGSRHSWSHHHEASTQADSSRHSQSGQ-GQSAGPRTSRNQGSSVSQDSDSQGHSEDSER 3554
Query: 336 PSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHS 395
S +S+ S+QE S + TS+ ED+ S E S + +H
Sbjct: 3555 WSGSASRNHRGSAQEQSRDGSRH------------PTSHHEDRAGHGHSAESSRQSGTHH 3602
Query: 396 KSESREEQADSESSESLNFSEESPESPEDENS-SSQEGLQSHSSSAESQSEESHSEEDDS 454
S QA S ++ + + E S +++ SS+ H ++ + + H S
Sbjct: 3603 AENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGS 3662
Query: 455 DSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRK 490
+ DS EDS+ T+S S+ + G + ES +
Sbjct: 3663 QASDSEGHSEDSD-TQSVSAHGQAGPHQQSHQESTR 3697
Score = 76.3 bits (186), Expect = 6e-14
Identities = 110/546 (20%), Positives = 194/546 (35%), Gaps = 64/546 (11%)
Query: 25 NESEDSEEW--KGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQ 82
N +++W GH+A T E+ ++++ ++ SD S + + H+
Sbjct: 219 NTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLLEENKIYERSRSSDGKSSSQ-VNRSRHE 277
Query: 83 YIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDR--------QEGGNSRL 134
++ SR+ + G D D G + SG ++ ++G
Sbjct: 278 NTSQVPLQESRTRKRRGSRVSQDRDSEGHSEDSERHSGSASRNHHGSAWEQSRDGSRHPR 337
Query: 135 GSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKP---EGGDSTQESESEE 191
DED +++ S G A+ T+S + + ++ S P G Q ++S
Sbjct: 338 SHDEDRASHGHSADSSRQSGTRHAE-TSSRGQTASSHEQARSSPGERHGSGHQQSADSSR 396
Query: 192 HWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNS----------------- 234
H G S+ D G Q+ D E SE +++ S
Sbjct: 397 HSATGRGQASSAVSDRGHRGSSGSQASDSEG-HSENSDTQSVSGHGKAGLRQQSHQESTR 455
Query: 235 --AGMKSKESGENSEQANTQD------------SGGSQLLEHPSRKIFRKSRISEE---- 276
+G +S SG + Q +T + +GG Q H + + S+E
Sbjct: 456 GRSGERSGRSGSSLYQVSTHEQPDSAHGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDT 515
Query: 277 ------DDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRD-SKGDSQEDSKENLSQEE 329
R ++ + V S+ T SQ R D S G S S ++ E
Sbjct: 516 IRGHPGSSRGGRQGSHHEQSVNRSGHSGSHHSHT-TSQGRSDASHGQSGSRSASRQTRNE 574
Query: 330 SQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTT-SYVEDQEDSDSSEEDS 388
Q+ DG S+ SSQ +SS + +S G S V DS EDS
Sbjct: 575 EQSGDGTRHSGSRHHEASSQADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDS 634
Query: 389 ---SHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSE 445
S + S + S +EQ+ S + E+ +SS + G + +S+ Q+
Sbjct: 635 ERWSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSADSSRKSGTRHTQNSSSGQAA 694
Query: 446 ESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKN-IEIESRKLTVDAYHNKPIGDQ 504
SH + S + + ++ S+ S GQ + + + + + G
Sbjct: 695 SSHEQARSSAGERHGSRHQLQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHS 754
Query: 505 DDNDCQ 510
+D+D Q
Sbjct: 755 EDSDTQ 760
Score = 75.5 bits (184), Expect = 1e-13
Identities = 118/525 (22%), Positives = 195/525 (37%), Gaps = 83/525 (15%)
Query: 20 TRYQNNESEDSEEWKGHLA----QAPTPPLESSESSEGSKVSSEEQANEDPSD------- 68
+R+ + ED GH A Q+ T ESS S G SS EQA +
Sbjct: 1954 SRHPGSHHED-RAGHGHSADSSRQSGTRHTESS--SRGQAASSHEQARSSAGERHGSHHQ 2010
Query: 69 ----STQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPK 124
+ G+G R +G S + D + ED +GP +
Sbjct: 2011 LQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDSEGHSEDSDTQSVSAQGKAGPHQQ 2070
Query: 125 DRQEGGNSRLGSDEDSD-------DTIQASE----ESAP-----QGQ--DSAQDTTSESR 166
+E + G T + SE +SAP QG D AQD++ S
Sbjct: 2071 SHKESARGQSGESSGRSGSFLYQVSTHEQSESTHGQSAPSTGGRQGSHYDQAQDSSRHSA 2130
Query: 167 ELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSE 226
+ +D + P ++ +E V S H S +G +SD +
Sbjct: 2131 SQEGQDTIRGHPGPSRGGRQGSHQEQSVDRSGHSGSHH---SHTTSQG-RSD------AS 2180
Query: 227 RGNSRMNSAGMKS---KESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELD 283
RG S SA K+ ++SG+ S + + S + + + + S R+
Sbjct: 2181 RGQSGSRSASRKTYDKEQSGDGSRHSGSHHHEASSWADSSRHSLVGQGQSS--GPRTSRP 2238
Query: 284 DNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVD----GPSSE 339
+++ + SDS +S + R+ G +QE S++ S + D G S+E
Sbjct: 2239 RGSSVSQ-DSDSEGHSEDSERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAE 2297
Query: 340 SSQEANLSSQENSSESQEEVVSE-SRGDNPDPTTSYVEDQEDSD-----------SSEED 387
SS+++ ENSS Q E +R + S+ + DS S+ D
Sbjct: 2298 SSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRD 2357
Query: 388 SSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENS-----------SSQEGLQSH 436
S H S S S++ + + SE S++ + S P ++ S + G +
Sbjct: 2358 SGHRGS-SGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLY 2416
Query: 437 SSSAESQSEESHSEEDDS-DSQDSSRSKEDSNSTESKSSSEEDGQ 480
S QSE +H S + S K+ +S S+ S+ ++GQ
Sbjct: 2417 QVSTHEQSESAHGRTGTSTGGRQGSHHKQARDS--SRHSTSQEGQ 2459
Score = 75.1 bits (183), Expect = 1e-13
Identities = 100/490 (20%), Positives = 172/490 (35%), Gaps = 48/490 (9%)
Query: 27 SEDSEEWKG------------HLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEE 74
SEDSE W G L P E G S++ + S
Sbjct: 2577 SEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSG 2636
Query: 75 GLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNS-- 132
G + H+ AG + G D S G + +D G S
Sbjct: 2637 GQAASSHEQARSSAGE------RHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGS 2690
Query: 133 ----RLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESE 188
G EDSD ++ A Q S Q++ + R + S + ++SE
Sbjct: 2691 QASDNEGHSEDSDTQSVSAHGQAGSHQQSHQES-ARGRSGETSGHSGSFLYQVSTHEQSE 2749
Query: 189 SEEHWVGGGSDGE--SSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENS 246
S W G + G S H + D ++IR G+SR G + S ++S
Sbjct: 2750 SSHGWTGPSTRGRQGSRHEQAQDSSRHSASQDGQDTIRGHPGSSRGGRQGYHHEHSVDSS 2809
Query: 247 EQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGL 306
+ + S + + + SR + R+E + S E S D
Sbjct: 2810 GHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDGSRHSGSRHHEASTHADISR 2869
Query: 307 -SQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRG 365
SQ + S+ ++ S + + +G S +S + + +S+ + +QE++ SR
Sbjct: 2870 HSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQLRDGSRH 2929
Query: 366 DNPDPTTSYVEDQ----EDSDSSEEDSSH---TLSHSKSESREEQADSESSE-------- 410
S+ ED+ +DSS + + T S ++ S EQA S + E
Sbjct: 2930 PR-----SHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQ 2984
Query: 411 SLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTE 470
S + S S +S+ ++ S +++ E HSE+ D+ S + +
Sbjct: 2985 SADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQSH 3044
Query: 471 SKSSSEEDGQ 480
+S+ G+
Sbjct: 3045 QESARGRSGE 3054
Score = 75.1 bits (183), Expect = 1e-13
Identities = 93/493 (18%), Positives = 170/493 (34%), Gaps = 55/493 (11%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQY 83
+ +SE S W G P+ E ++ SS A++D D+ + G Q
Sbjct: 2745 HEQSESSHGWTG-----PSTRGRQGSRHEQAQDSSRHSASQDGQDTIRGHPGSSRGGRQG 2799
Query: 84 IYR---------LAGGFSRSTGKGGDDKDDDEDDS--------GDDTFGDDDSGPGPKDR 126
+ S +T +G D + S ++ GD G +
Sbjct: 2800 YHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDGSRHSGSRHH 2859
Query: 127 QEGGNSRLGSDEDS-DDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQ 185
+ ++ + + + S S QG +QD+ SE D+E S +
Sbjct: 2860 EASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSA 2919
Query: 186 ESE----------SEEHWVGGGSDGESSHGDGS---ELDDEGMQSDDPESIRSERGNSRM 232
+ + +E G G +SS G+ + G + E RS G
Sbjct: 2920 QEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERH- 2978
Query: 233 NSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVK 292
G ++S ++S + S + + + S+ S+ + SE D ++
Sbjct: 2979 ---GSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHG 3035
Query: 293 SDSTENSNSRDT--GLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQ-----EAN 345
+ + +++ G S G + E S GPS+ Q +A
Sbjct: 3036 QAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQ 3095
Query: 346 LSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDS--SHTLSHSKSESREEQ 403
SS+ ++S+ ++ + G + Y + S S SHT S +S++ Q
Sbjct: 3096 DSSRHSASQYGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQ 3155
Query: 404 ADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSK 463
+ S S+ +EE SS+ + H ++ HS+ S+ S RS+
Sbjct: 3156 SGSRSASRTTRNEEQ------SGDSSRHSVSRHHEASTHADISRHSQAVQGQSEGSRRSR 3209
Query: 464 EDSNSTESKSSSE 476
+S S SE
Sbjct: 3210 RQGSSVSQDSDSE 3222
Score = 73.9 bits (180), Expect = 3e-13
Identities = 97/452 (21%), Positives = 161/452 (35%), Gaps = 46/452 (10%)
Query: 47 SSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDE 106
+ SS G VSS EQA P + S +D SR +G G
Sbjct: 1334 TESSSHGQAVSSHEQARSSPGERHGSRHQQSADS-----------SRHSGIGHRQASSAV 1382
Query: 107 DDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSD-DTIQASEESAPQGQDSAQDTTSES 165
DSG G Q + G EDSD ++ A ++ P Q + +S
Sbjct: 1383 RDSGHR---------GSSGSQVTNSE--GHSEDSDTQSVSAHGQAGPHQQSHKESARGQS 1431
Query: 166 RELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRS 225
E R ES + G S H D ++IR
Sbjct: 1432 GESSGRSRSFLYQVSSHEQSESTHGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIRG 1491
Query: 226 ERGNSRMNSAGMKSKESGENS-----EQANTQDSGGSQLLEHPS--RKIFRKSRISEEDD 278
G+SR G ++S + S ++T G S S R R++R E+
Sbjct: 1492 HPGSSRGGRQGSYHEQSVDRSGHSGYHHSHTTPQGRSDASHGQSGPRSASRQTRNEEQSG 1551
Query: 279 RSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSS 338
+ E ST +SR SQ + S+ ++ S + ++ +G S
Sbjct: 1552 DGSRHSGSRHHE---PSTRAGSSRH---SQVGQGESAGSKTSRRQGSSVSQDRDSEGHSE 1605
Query: 339 ESSQEANLSSQENSSESQEEVVSESRG--DNPDPTTSYVEDQEDSDSSEEDSSHTLSHSK 396
+S + + +S+ + ++E+ SR + + S+ E S S + T S +
Sbjct: 1606 DSERRSESASRNHYGSAREQSRHGSRNPRSHQEDRASHGHSAESSRQSGTRHAETSSGGQ 1665
Query: 397 SESREEQADSESSE--------SLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESH 448
+ S +EQA S E S + S +S ++S + SS +++ E H
Sbjct: 1666 AASSQEQARSSPGERHGSRHQQSADSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDSEGH 1725
Query: 449 SEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ 480
SEE D+ S + + +S+ + G+
Sbjct: 1726 SEESDTQSVSAHGQAGPHQQSHQESTRGQSGE 1757
Score = 73.2 bits (178), Expect = 5e-13
Identities = 101/487 (20%), Positives = 165/487 (33%), Gaps = 44/487 (9%)
Query: 27 SEDSEEWKG------------HLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEE 74
SEDSE W G L P E G S++ + S
Sbjct: 2901 SEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSG 2960
Query: 75 GLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNS-- 132
G + H+ AG + G D S G + +D G S
Sbjct: 2961 GQAASSHEQARSSAGE------RHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGS 3014
Query: 133 ----RLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESE 188
G EDSD ++ A Q S Q++ + R + S + ++SE
Sbjct: 3015 QASDNEGHSEDSDTQSVSAHGQAGSHQQSHQES-ARGRSGETSGHSGSFLYQVSTHEQSE 3073
Query: 189 SEEHWVGGGSDGE--SSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGM-------KS 239
S W G + G S H + ++IR G+SR G S
Sbjct: 3074 SSHGWTGPSTRGRQGSRHEQAQDSSRHSASQYGQDTIRGHPGSSRGGRQGYHHEHSVDSS 3133
Query: 240 KESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENS 299
SG + +Q + + SR R +R E+ S + E + + +
Sbjct: 3134 GHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTHADISR 3193
Query: 300 NSRDT-GLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEE 358
+S+ G S+ R S+ S+++ S+ S++ + S +S+ S QE S
Sbjct: 3194 HSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQSRHGSRH 3253
Query: 359 VVSE-----SRGDNPDPTT-SYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESL 412
S G + D + S E S + SSH + S R +S++S
Sbjct: 3254 PRSHHEDRAGHGHSADRSRQSGTRHAETSSGGQAASSHEQARSSPGERHGSRHQQSADS- 3312
Query: 413 NFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESK 472
S S +S+ ++ SS +++ E HSEE D+ S + +
Sbjct: 3313 --SRHSGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQSVSGHGQAGPHQQSHQE 3370
Query: 473 SSSEEDG 479
S+ + G
Sbjct: 3371 SARDRSG 3377
Score = 72.8 bits (177), Expect = 7e-13
Identities = 102/451 (22%), Positives = 166/451 (36%), Gaps = 39/451 (8%)
Query: 46 ESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQ-YIYRLAGGFSRSTGKGGDDKDD 104
+S + S S ++ SD+++ + G S + Y +G SR +G +
Sbjct: 2156 QSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRKTYDKEQSGDGSRHSGSHHHEASS 2215
Query: 105 DEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDED--SDDTIQASEESAPQGQDSAQDTT 162
D S G S R G + SD + S+D+ + S ++ SAQ+ +
Sbjct: 2216 WADSSRHSLVGQGQSSGPRTSRPRGSSVSQDSDSEGHSEDSERRSGSASRNHHGSAQEQS 2275
Query: 163 SESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGE--SSHGDGSELDDEGMQSDDP 220
+ D G + +S H S G+ SSH E S
Sbjct: 2276 RDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQ 2335
Query: 221 ESIRSER----GNSRMNSAGMKSKESGENSEQAN-----TQDSGGSQLLEH----PSRKI 267
+S S R G+ + +SA S G + QA+ ++DS + H P ++
Sbjct: 2336 QSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQS 2395
Query: 268 FRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQ--EDSKENL 325
++S RS + + + +E+++ R TG S R Q + S+ +
Sbjct: 2396 HQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGR-TGTSTGGRQGSHHKQARDSSRHST 2454
Query: 326 SQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSE 385
SQE + G SS ++ S Q S G + TTS
Sbjct: 2455 SQEGQDTIHGHPGSSS-----GGRQGSHYEQLVDRSGHSGSHHSHTTS---------QGR 2500
Query: 386 EDSSHTLSHSKSESREEQADSESSESLNFS---EESPESPEDENSSSQEGLQSHSSSAES 442
D+SH S S+S SR+ + D +S + S S D + SQ G Q S +
Sbjct: 2501 SDASHGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASSRADSSGHSQVG-QGQSEGPRT 2559
Query: 443 QSEESHSEEDDSDSQDSSRSKEDSNSTESKS 473
S DSDSQ S E + + S++
Sbjct: 2560 SRNWGSSFSQDSDSQGHSEDSERWSGSASRN 2590
Score = 71.2 bits (173), Expect = 2e-12
Identities = 107/520 (20%), Positives = 171/520 (32%), Gaps = 73/520 (14%)
Query: 20 TRYQNNESEDSEEWKGHLAQAP--TPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLG 77
+R+ + ED GH A + + + SS G SS EQA P + S
Sbjct: 333 SRHPRSHDEDRAS-HGHSADSSRQSGTRHAETSSRGQTASSHEQARSSPGERHGSGHQQS 391
Query: 78 SDDHQYIYRLAGGFSRST------GKGGDDKDDDEDDS-GDDT---FGDDDSGPGPKDRQ 127
+D ++ G S + G G D E S DT G +G + Q
Sbjct: 392 ADSSRHSATGRGQASSAVSDRGHRGSSGSQASDSEGHSENSDTQSVSGHGKAGLRQQSHQ 451
Query: 128 EGGNSRLG--SDEDSDDTIQASEESAPQG----------------QDSAQDTTSESRELD 169
E R G S Q S P + A+D++ S +
Sbjct: 452 ESTRGRSGERSGRSGSSLYQVSTHEQPDSAHGRTGTSTGGRQGSHHEQARDSSRHSASQE 511
Query: 170 NEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGN 229
+D + P ++ E V S H + S + R
Sbjct: 512 GQDTIRGHPGSSRGGRQGSHHEQSVNRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQT 571
Query: 230 SRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTME 289
+G ++ SG +A++Q R S++ + N
Sbjct: 572 RNEEQSGDGTRHSGSRHHEASSQADSS------------RHSQVGQGQSSGPRTSRNQGS 619
Query: 290 EVKSDSTENSNSRDTGL--SQPRRDSKGDSQEDSKENLSQEESQNVD----GPSSESSQE 343
V DS +S D+ R+ G +QE S++ S + D G S++SS++
Sbjct: 620 SVSQDSDSQGHSEDSERWSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSADSSRK 679
Query: 344 ANLSSQENSSESQ----EEVVSESRGD---------NPDPTTSYVEDQEDSDSSEEDSSH 390
+ +NSS Q E S G+ + D + + S+ DS H
Sbjct: 680 SGTRHTQNSSSGQAASSHEQARSSAGERHGSRHQLQSADSSRHSGTGHGQASSAVRDSGH 739
Query: 391 --------TLSHSKSESREEQADSESSESLNFSEESPESPEDENS--SSQEGLQSHSSSA 440
T S SE + Q+ S ++ + + ES D + S + G + S
Sbjct: 740 RGSSGSQATDSEGHSEDSDTQSVSGHGQAGHHQQSHQESARDRSGERSRRSGSFLYQVST 799
Query: 441 ESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ 480
QSE SH S E + S+ S+ +DGQ
Sbjct: 800 HKQSESSHGWTGPSTGVRQGSHHEQARD-NSRHSASQDGQ 838
Score = 71.2 bits (173), Expect = 2e-12
Identities = 91/462 (19%), Positives = 163/462 (35%), Gaps = 25/462 (5%)
Query: 49 ESSEGSKVS--SEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDE 106
+S +GS+ S +A+ S S+ G G R G +D E
Sbjct: 3494 QSGDGSRHSWSHHHEASTQADSSRHSQSGQGQSAGPRTSRNQGSSVSQDSDSQGHSEDSE 3553
Query: 107 DDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESR 166
SG + + G + ++G ED ++E S G A++++
Sbjct: 3554 RWSGSAS--RNHRGSAQEQSRDGSRHPTSHHEDRAGHGHSAESSRQSGTHHAENSSGGQA 3611
Query: 167 ELDNEDRVDSKPE--GGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIR 224
+E S E G Q ++S H G S+ D G Q+ D E
Sbjct: 3612 ASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHS 3671
Query: 225 SERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDR---SE 281
+ +++ G + E + +G S ++ + R S
Sbjct: 3672 EDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRAGPST 3731
Query: 282 LDDNNTMEEVKSDSTENSNSR---DTGLSQP--RRDSKGDSQEDSKENLSQEESQNVDGP 336
+ E DS+ +S S+ DT P RR + S + + S +
Sbjct: 3732 GGRQGSRHEQARDSSRHSASQEGQDTIRGHPGSRRGGRQGSYHEQSVDRSGHSGSHHSHT 3791
Query: 337 SSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSK 396
+S+ +A+ + S S+E E GD + S + S++ DSS +
Sbjct: 3792 TSQGRSDASHGQSGSRSASRETRNEEQSGDGSRHSGS----RHHEASTQADSSRHSQSGQ 3847
Query: 397 SESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDS 456
ES + S++ +S PED S+ ++H S+ QS + S S
Sbjct: 3848 GESAGSRRSRRQGSSVSQDSDSEAYPEDSERRSESASRNHHGSSREQSRDG-SRHPGSSH 3906
Query: 457 QDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHN 498
+D++ + S S+++E G ++ +S AYH+
Sbjct: 3907 RDTASHVQSSPVQSDSSTAKEHGHFSSLSQDS------AYHS 3942
Score = 70.1 bits (170), Expect = 5e-12
Identities = 93/468 (19%), Positives = 159/468 (33%), Gaps = 42/468 (8%)
Query: 46 ESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDD 105
E + SS G + S Q + D S G+G R +G S + D++
Sbjct: 2968 EQARSSAGERHGSHHQQSADSS----RHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHS 3023
Query: 106 EDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSD-------DTIQASEES-------- 150
ED +G + QE R G T + SE S
Sbjct: 3024 EDSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPST 3083
Query: 151 -APQGQ--DSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDG 207
QG + AQD++ S +D + P ++ EH V S H
Sbjct: 3084 RGRQGSRHEQAQDSSRHSASQYGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHT 3143
Query: 208 SELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQD--SGGSQLLEHPSR 265
+ S + R +G S+ S +A+T S SQ ++ S
Sbjct: 3144 TSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTHADISRHSQAVQGQSE 3203
Query: 266 KIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSK----------- 314
R R + + ++ + + + + N R + Q R S+
Sbjct: 3204 GSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQSRHGSRHPRSHHEDRAG 3263
Query: 315 -GDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESR--GDNPDPT 371
G S + S+++ ++ + G ++ S ++A S E ++ SR G
Sbjct: 3264 HGHSADRSRQSGTRHAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRGQA 3323
Query: 372 TSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENS--SS 429
+S V D SS +S + HS E + Q+ S ++ + ES D + S
Sbjct: 3324 SSAVRDSRHWGSSGSQASDSEGHS--EESDTQSVSGHGQAGPHQQSHQESARDRSGGRSG 3381
Query: 430 QEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEE 477
+ G + S QSE +H S + E + + S+S+E
Sbjct: 3382 RSGSFLYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQE 3429
Score = 68.9 bits (167), Expect = 1e-11
Identities = 113/532 (21%), Positives = 191/532 (35%), Gaps = 97/532 (18%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGL------G 77
+ +SE S W G P+ + E ++ +S A++D D+ + G G
Sbjct: 800 HKQSESSHGWTG-----PSTGVRQGSHHEQARDNSRHSASQDGQDTIRGHPGSSRRGRQG 854
Query: 78 SDDHQYIYRLAGG---FSRSTGKGGDDKDDDEDDS--------GDDTFGDDDSGPGPKDR 126
S Q + R S +T +G D + S ++ D G +
Sbjct: 855 SHHEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSRDGSRHSGSRHH 914
Query: 127 QEGGNSRLGSDEDSDD-TIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQ 185
+ ++ + + + S S QG +QD+ SE D+E S +
Sbjct: 915 EASSHADISRHSQAGQGQSEGSRTSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSA 974
Query: 186 ESESE----------EHWVGGGSDGESSHGDGS---ELDDEGMQSDDPESIRS---ERGN 229
+ +S E G G +SS G+ E G + E RS ER
Sbjct: 975 QEQSRHGSRHPRSHHEDRAGHGHSADSSRQSGTPHAETSSGGQAASSHEQARSSPGERHG 1034
Query: 230 SRMNSAGMKSKESGENSEQANT--QDSG--GSQLLEHPSRKIFRKSRISEEDDRSELDDN 285
SR + S+ SG QA++ +DSG GS S+ S+ + SE D
Sbjct: 1035 SRHQQSADSSRHSGIPRRQASSAVRDSGHWGSS-----------GSQASDSEGHSEESDT 1083
Query: 286 NTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQ----EESQNVDGPSSESS 341
++ D + +++ RD G S + Q E+S++ G + S+
Sbjct: 1084 QSVSGHGQDGPHQQSHQESA-----RDWSGGRSGRSGSFIYQVSTHEQSESAHGRTRTST 1138
Query: 342 QEANLSSQENSSESQEEVVSESRGDN--PDPTTSYVEDQ-EDSDSSEEDSSHTLSH---- 394
S E + +S S+ D P + Q + S + S H+ SH
Sbjct: 1139 GRRQGSHHEQARDSSRHSASQEGQDTIRAHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHT 1198
Query: 395 --------------SKSESREEQADSESS-----------ESLNFSEESPESPEDENSSS 429
S+S SR+ + D +S E+ ++++ S S + SS
Sbjct: 1199 TSQGRSDASHGQSGSRSASRQTRKDKQSGDGSRHSGSRHHEAASWADSSRHSQVGQEQSS 1258
Query: 430 QEGLQSHSSSAESQSEESHSEEDDSD--SQDSSRSKEDSNSTESKSSSEEDG 479
H S+ SQ +S DDS+ S +SR+ S+ +S+ S G
Sbjct: 1259 GSRTSRHQGSSVSQDSDSERHSDDSERLSGSASRNHHGSSREQSRDGSRHPG 1310
Score = 68.9 bits (167), Expect = 1e-11
Identities = 100/483 (20%), Positives = 177/483 (36%), Gaps = 35/483 (7%)
Query: 20 TRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANED---PSDSTQSEEGL 76
+R+Q + ++ G + + S GS+ S E +E+ S S + G
Sbjct: 1683 SRHQQSADSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDSEGHSEESDTQSVSAHGQAGP 1742
Query: 77 GSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDR----QEGGNS 132
HQ R G RS G + + G G + R Q +S
Sbjct: 1743 HQQSHQESTRGQSG-ERSGRSGSFLYQVSTHEQSESAHGRTGPSTGGRQRSRHEQARDSS 1801
Query: 133 RLGSDEDSDDTIQASEESAPQGQ---------DSAQDTTSESRELDNEDRVD-SKPEGGD 182
R + ++ DTI+ S+ G+ DS+ + S +++R D S+ + G
Sbjct: 1802 RHSASQEGQDTIRGHPGSSRGGRQGSHYEQSVDSSGHSGSHHSHTTSQERSDVSRGQSGS 1861
Query: 183 S--TQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK 240
++++ +E+ G S H + S D S + S SR N S+
Sbjct: 1862 RSVSRQTRNEKQSGDGSRHSGSRHHEASSRADSSRHSQVGQGQSSGPRTSR-NQGSSVSQ 1920
Query: 241 ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSN 300
+S +++ GS H + +SR S +D +DS+ S
Sbjct: 1921 DSDSQGHSEDSERWSGSASRNHLG-SAWEQSRDGSRHPGSHHED-RAGHGHSADSSRQSG 1978
Query: 301 SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVV 360
+R T S R S E ++ + + + S++SS+ + + + SS ++
Sbjct: 1979 TRHTESSS--RGQAASSHEQARSSAGERHGSHHQLQSADSSRHSGIGHGQASSAVRDSGH 2036
Query: 361 SESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNF-----S 415
G + + ED + S + + S ES Q+ S S +F +
Sbjct: 2037 RGYSGSQASDSEGHSEDSDTQSVSAQGKAGPHQQSHKESARGQSGESSGRSGSFLYQVST 2096
Query: 416 EESPESPEDENSSSQEGLQ-SHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSS 474
E ES +++ S G Q SH A+ S S S+E QD+ R + + S
Sbjct: 2097 HEQSESTHGQSAPSTGGRQGSHYDQAQDSSRHSASQE----GQDTIRGHPGPSRGGRQGS 2152
Query: 475 SEE 477
+E
Sbjct: 2153 HQE 2155
Score = 68.2 bits (165), Expect = 2e-11
Identities = 103/460 (22%), Positives = 162/460 (35%), Gaps = 49/460 (10%)
Query: 27 SEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLG-SDDHQYIY 85
SEDSE W G +S + GS + P + G G S D
Sbjct: 1928 SEDSERWSG----------SASRNHLGSAWEQSRDGSRHPGSHHEDRAGHGHSADSSRQS 1977
Query: 86 RLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQ 145
S S G+ + +G+ R G +G + S
Sbjct: 1978 GTRHTESSSRGQAASSHEQARSSAGERHGSHHQLQSADSSRHSG----IGHGQASS---- 2029
Query: 146 ASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHG 205
A +S +G +Q + SE D++ + S Q+S E G GESS
Sbjct: 2030 AVRDSGHRGYSGSQASDSEGHSEDSDTQSVSAQGKAGPHQQSHKES---ARGQSGESSGR 2086
Query: 206 DGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK--ESGENSEQANTQDSGGSQLLEHP 263
GS L Q E S G S ++ G + + ++S + + G + HP
Sbjct: 2087 SGSFL----YQVSTHEQSESTHGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIRGHP 2142
Query: 264 SRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRD-SKGDSQEDSK 322
R R ++S +D +S + + +S T SQ R D S+G S S
Sbjct: 2143 GPS--RGGRQGSHQEQS-VD--------RSGHSGSHHSHTT--SQGRSDASRGQSGSRSA 2189
Query: 323 ENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPD---PTTSYVEDQE 379
+ ++ Q+ DG S SS +SS + +V + + P P S V
Sbjct: 2190 SRKTYDKEQSGDGSRHSGSHHHEASSWADSS--RHSLVGQGQSSGPRTSRPRGSSVSQDS 2247
Query: 380 DSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSS 439
DS+ EDS S S S + A +S + E S++ QS +
Sbjct: 2248 DSEGHSEDSERR-SGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGTHH 2306
Query: 440 AESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDG 479
AE+ S + ++ S+ + S+ +S SS G
Sbjct: 2307 AEN-SSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSG 2345
Score = 67.8 bits (164), Expect = 2e-11
Identities = 110/477 (23%), Positives = 161/477 (33%), Gaps = 68/477 (14%)
Query: 22 YQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDD- 80
YQ + E SE G + S+ G + S +QA + ST E G D
Sbjct: 2416 YQVSTHEQSESAHGR----------TGTSTGGRQGSHHKQARDSSRHSTSQE---GQDTI 2462
Query: 81 HQYIYRLAGG---------FSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPK----DRQ 127
H + +GG RS G D + G S + D Q
Sbjct: 2463 HGHPGSSSGGRQGSHYEQLVDRSGHSGSHHSHTTSQGRSDASHGHSGSRSASRQTRNDEQ 2522
Query: 128 EGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQES 187
G SR + + +A Q + SR + DS DS S
Sbjct: 2523 SGDGSRHSGSRHHEASSRADSSGHSQVGQGQSEGPRTSRNWGSSFSQDS-----DSQGHS 2577
Query: 188 ESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSE 247
E E W G S + HG E +G S P S + +R S +S S
Sbjct: 2578 EDSERWSGSAS--RNHHGSAQEQLRDG--SRHPRSHQEDRAGHG------HSADSSRQSG 2627
Query: 248 QANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKS-DSTENSNSRDTGL 306
+TQ S G Q S E RS + + +S DS+ +S
Sbjct: 2628 TRHTQTSSGGQAAS------------SHEQARSSAGERHGSHHQQSADSSRHSGIGHGQA 2675
Query: 307 SQPRRDS--KGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESR 364
S RDS +G S + +N E + S+ ++ S + S+ + S
Sbjct: 2676 SSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHS 2735
Query: 365 GDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPED 424
G V E S+SS + + + + SR EQA S S S++ ++
Sbjct: 2736 GS----FLYQVSTHEQSESSHGWTGPS-TRGRQGSRHEQAQDSSRHSA--SQDGQDTIRG 2788
Query: 425 ENSSSQEGLQS----HSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEE 477
SS+ G Q HS + S HS D+SR + S S + +EE
Sbjct: 2789 HPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEE 2845
Score = 67.4 bits (163), Expect = 3e-11
Identities = 93/445 (20%), Positives = 162/445 (36%), Gaps = 39/445 (8%)
Query: 46 ESSESSEGSKVSSEEQANEDPSDSTQSEEG---------LGSDDHQYIYRLAGGFSRSTG 96
++S GS+ +S + NE+ S G S H + + R++
Sbjct: 556 DASHGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQADSSRHSQVGQGQSSGPRTSR 615
Query: 97 KGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQD 156
G D D G D + G R G+++ S + S E+ A G
Sbjct: 616 NQGSSVSQDSDSQGHSE--DSERWSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHS 673
Query: 157 SAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQ 216
+ S +R N + + + S E H GS + D S G
Sbjct: 674 ADSSRKSGTRHTQNSSSGQAA-SSHEQARSSAGERH----GSRHQLQSADSSRHSGTG-- 726
Query: 217 SDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQD-SGGSQLLEHP-SRKIFRKSRIS 274
++ + R + S+G ++ +S +SE ++TQ SG Q H S + + R
Sbjct: 727 --HGQASSAVRDSGHRGSSGSQATDSEGHSEDSDTQSVSGHGQAGHHQQSHQESARDRSG 784
Query: 275 EEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVD 334
E RS +S+S+ TG+ Q + ++++S+ + SQ+ +
Sbjct: 785 ERSRRSGSFLYQVSTHKQSESSHGWTGPSTGVRQGSHHEQ--ARDNSRHSASQDGQDTIR 842
Query: 335 GPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSH 394
G S + S E S + S G + TTS Q SD+S S +
Sbjct: 843 GHPGSSRRGRQGSHHEQSVDR-----SGHSGSHHSHTTS----QGRSDASRGQSGSRSAS 893
Query: 395 SKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQ----SEESHSE 450
+ + E+ D E S + +S + +G S ++ Q S++S SE
Sbjct: 894 RTTRNEEQSRDGSRHSGSRHHEASSHADISRHSQAGQGQSEGSRTSRRQGSSVSQDSDSE 953
Query: 451 --EDDSDSQDSSRSKEDSNSTESKS 473
+DS+ S S+ S + +S
Sbjct: 954 GHSEDSERWSGSASRNHRGSAQEQS 978
Score = 66.2 bits (160), Expect = 7e-11
Identities = 91/438 (20%), Positives = 153/438 (34%), Gaps = 30/438 (6%)
Query: 46 ESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDD 105
E + SS G + S Q + D S G+G R +G S + D +
Sbjct: 2320 EQARSSAGERHGSHHQQSADSS----RHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHS 2375
Query: 106 EDDSGDDTFGDDDSGPGPKDRQEG--GNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTS 163
ED +GP + QE G S S Q S + T++
Sbjct: 2376 EDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRTGTST 2435
Query: 164 ESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESI 223
R+ + + S QE + H G S G +L D S S
Sbjct: 2436 GGRQGSHHKQARDSSRHSTS-QEGQDTIHGHPGSSSGGRQGSHYEQLVDRSGHSGSHHSH 2494
Query: 224 RSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELD 283
+ +G S S G S + + Q GS+ SR E R++
Sbjct: 2495 TTSQGRSDA-SHGHSGSRSASRQTRNDEQSGDGSR---------HSGSRHHEASSRADSS 2544
Query: 284 DNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQE 343
++ + + +S+ S + + SQ DS+G S++ E S S+N G S+QE
Sbjct: 2545 GHSQVGQGQSEGPRTSRNWGSSFSQDS-DSQGHSEDS--ERWSGSASRNHHG----SAQE 2597
Query: 344 ANLSSQENSSESQEEVVSESRGDNPDPTT-SYVEDQEDSDSSEEDSSHTLSHSKSESREE 402
+ QE+ G + D + S + S + SSH + S + R
Sbjct: 2598 QLRDGSRHPRSHQED--RAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHG 2655
Query: 403 QADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRS 462
+S++S S S +S+ ++ S +++ E HSE+ D+ S +
Sbjct: 2656 SHHQQSADS---SRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQ 2712
Query: 463 KEDSNSTESKSSSEEDGQ 480
+ +S+ G+
Sbjct: 2713 AGSHQQSHQESARGRSGE 2730
Score = 64.3 bits (155), Expect = 3e-10
Identities = 95/450 (21%), Positives = 156/450 (34%), Gaps = 50/450 (11%)
Query: 27 SEDSEEWKGHLAQ------------APTPPLESSESSEGSKVSSEEQANEDPSDSTQSEE 74
SEDSE W G ++ P E G S+E + S
Sbjct: 3549 SEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGHGHSAESSRQSGTHHAENSSG 3608
Query: 75 GLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRL 134
G + H+ AG + G D S G + +D G+S
Sbjct: 3609 GQAASSHEQARSSAGE------RHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGS 3662
Query: 135 ------GSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESE 188
G EDSD ++ A Q S Q++T R R S + ++SE
Sbjct: 3663 QASDSEGHSEDSDTQSVSAHGQAGPHQQSHQEST-RGRSAGRSGRSGSFLYQVSTHEQSE 3721
Query: 189 SEEHWVGGGSDGE--SSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENS 246
S G + G S H + + ++IR G+ R G ++S + S
Sbjct: 3722 SAHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIRGHPGSRRGGRQGSYHEQSVDRS 3781
Query: 247 EQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGL 306
+ + S + S+ + + + E +++ SR +G
Sbjct: 3782 GHSGSHHSHTT-------------SQGRSDASHGQSGSRSASRETRNEEQSGDGSRHSGS 3828
Query: 307 SQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGD 366
++ DS S + Q S S ++ + SQ++ SE+ E SE R +
Sbjct: 3829 RHHEASTQADSSRHS------QSGQGESAGSRRSRRQGSSVSQDSDSEAYPED-SERRSE 3881
Query: 367 NPDPTTSYVEDQEDSDSSEED-SSHTLSHSKSESREEQADSESS-ESLNFSEESPESPED 424
+ ++ D S SSH + S +S Q+DS ++ E +FS S +S
Sbjct: 3882 SASRNHHGSSREQSRDGSRHPGSSHRDTASHVQSSPVQSDSSTAKEHGHFSSLSQDSAYH 3941
Query: 425 ENSSSQEGLQSHSSSAESQSEESHSEEDDS 454
S+ G SSS QSE + ++ S
Sbjct: 3942 SGIQSR-GSPHSSSSYHYQSEGTERQKGQS 3970
Score = 60.1 bits (144), Expect = 5e-09
Identities = 85/392 (21%), Positives = 137/392 (34%), Gaps = 44/392 (11%)
Query: 46 ESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDD 105
E + SS G + S Q + D S G+G R +G S + D +
Sbjct: 3616 EQARSSAGERHGSHHQQSADSS----RHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHS 3671
Query: 106 EDDSGDDTFGDDDSGPGPKDRQE-------GGNSRLGSDEDSDDTIQASEES-------- 150
ED +GP + QE G + R GS T + SE +
Sbjct: 3672 EDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRAGPST 3731
Query: 151 -APQG--QDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWV--GGGSDGESSHG 205
QG + A+D++ S + +D + P ++ E V G S SH
Sbjct: 3732 GGRQGSRHEQARDSSRHSASQEGQDTIRGHPGSRRGGRQGSYHEQSVDRSGHSGSHHSHT 3791
Query: 206 DGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQ-----DSGGSQLL 260
D S E N + G S+ SG +A+TQ S Q
Sbjct: 3792 TSQGRSDASHGQSGSRSASRETRNEEQSGDG--SRHSGSRHHEASTQADSSRHSQSGQGE 3849
Query: 261 EHPSRKIFRK-SRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQE 319
SR+ R+ S +S++ D +++ + + +SR+ RD
Sbjct: 3850 SAGSRRSRRQGSSVSQDSDSEAYPEDSERRSESASRNHHGSSREQS-----RDGSRHPGS 3904
Query: 320 DSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQE 379
++ S +S V SS + + + SS S + +SRG +P ++SY E
Sbjct: 3905 SHRDTASHVQSSPVQSDSSTAKEHGHFSSLSQDSAYHSGI--QSRG-SPHSSSSYHYQSE 3961
Query: 380 DSDSSEEDSSHTLSHSKSESREEQADSESSES 411
++ + S H S AD + ES
Sbjct: 3962 GTERQKGQSGLVWRHGSYGS----ADYDYGES 3989
Score = 57.8 bits (138), Expect = 2e-08
Identities = 93/449 (20%), Positives = 165/449 (36%), Gaps = 43/449 (9%)
Query: 49 ESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDD 108
+ E +K ++ + PS + G+ R GG + ++
Sbjct: 108 DKHEDNKQEENKENRKRPSSLERRNNRKGNKGRSKSPRETGGKRHESSSEKKERKGYSPT 167
Query: 109 SGDDTFGDDDSGPGPKDRQEGGNSRLGSD-----------EDSDDTIQASEESAPQGQ-- 155
++ +G + K++ + N+RLG + ED+++ + E + Q
Sbjct: 168 HREEEYGKNHHNSSKKEKNKTENTRLGDNRKRLSERLEEKEDNEEGVYDYENTGRMTQKW 227
Query: 156 -DSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEG 214
S T + + + D DS E + S S SDG+SS S+++
Sbjct: 228 IQSGHIATYYTIQDEAYDTTDSLLEENKIYERSRS--------SDGKSS----SQVNRSR 275
Query: 215 MQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEH-----PSRKIFR 269
++ ++ R R S + ++S +SE + + SG + H SR R
Sbjct: 276 HENTSQVPLQESRTRKRRGSRVSQDRDSEGHSEDSE-RHSGSASRNHHGSAWEQSRDGSR 334
Query: 270 KSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEE 329
R +ED S ++ + + E S+ T S + S + S S +
Sbjct: 335 HPRSHDEDRASHGHSADSSRQSGTRHAETSSRGQTASSHEQARSSPGERHGSGHQQSADS 394
Query: 330 SQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSS 389
S++ ++S + SS SQ S+S G + + T V + ++ S
Sbjct: 395 SRHSATGRGQASSAVSDRGHRGSSGSQ---ASDSEGHSENSDTQSVSGHGKAGLRQQ--S 449
Query: 390 HTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ-SHSSSAESQSEESH 448
H S ++ S E S SS + E P+S +S G Q SH A S S
Sbjct: 450 HQES-TRGRSGERSGRSGSSLYQVSTHEQPDSAHGRTGTSTGGRQGSHHEQARDSSRHSA 508
Query: 449 SEEDDSDSQDSSRSKEDSNSTESKSSSEE 477
S+E QD+ R S+ + S E
Sbjct: 509 SQE----GQDTIRGHPGSSRGGRQGSHHE 533
Score = 48.1 bits (113), Expect = 2e-05
Identities = 55/265 (20%), Positives = 103/265 (38%), Gaps = 51/265 (19%)
Query: 244 ENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRD 303
E++ + N SG H RK S + +D + ++ + S N+ +
Sbjct: 87 ESTRKENLPISG------HKHRK---HSHHDKHEDNKQEENKENRKRPSSLERRNNRKGN 137
Query: 304 TGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSES 363
G S+ R++ G E S E ++ G S +E + NSS+ ++ +
Sbjct: 138 KGRSKSPRETGGKRHESSSEKKERK------GYSPTHREEEYGKNHHNSSKKEKNKTENT 191
Query: 364 R-GDNPDPTTSYVEDQEDSDSSEEDSSHT------------------------------L 392
R GDN + +E++ED++ D +T L
Sbjct: 192 RLGDNRKRLSERLEEKEDNEEGVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLL 251
Query: 393 SHSKSESREEQADSESSESLNFS--EESPESPEDENSSSQEGLQSHSSSAESQSEESHSE 450
+K R +D +SS +N S E + + P E+ + + + S ++ + E HSE
Sbjct: 252 EENKIYERSRSSDGKSSSQVNRSRHENTSQVPLQESRTRK---RRGSRVSQDRDSEGHSE 308
Query: 451 EDDSDSQDSSRSKEDSNSTESKSSS 475
+ + S +SR+ S +S+ S
Sbjct: 309 DSERHSGSASRNHHGSAWEQSRDGS 333
>gi|24415404 MDN1, midasin homolog [Homo sapiens]
Length = 5596
Score = 90.5 bits (223), Expect = 3e-18
Identities = 92/400 (23%), Positives = 156/400 (39%), Gaps = 22/400 (5%)
Query: 104 DDEDDSGDDTFGD-DDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTT 162
+D G F D + G G + + + ++G++E +DT Q +E + DS D
Sbjct: 4662 EDSAGEGATEFHDYEGGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIK 4721
Query: 163 SESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGD--GSELD--DEGMQSD 218
E ++ + D K G+ ++ E +E G D + GD G E D DE + D
Sbjct: 4722 GEDNAIEMSEDFDGKMHDGELEEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGD 4781
Query: 219 DPESIRSERGNSRMNSAGM-KSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEED 277
D E E +++ G +E E + + DSG S + K K +E D
Sbjct: 4782 DDEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEE-AEAD 4840
Query: 278 DRSELDDNNTMEEVKSDSTENS----NSRDTGLSQPRR-DSKGDSQEDSKENLSQEESQN 332
D + +D + + D EN + + +P D D DS++ E++ N
Sbjct: 4841 DGGQGEDKINEQIDERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDN 4900
Query: 333 VDGPS------SESSQEANLSSQE--NSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSS 384
+G E +EA ++E + Q E S + E +E+ D+
Sbjct: 4901 EEGEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTG 4960
Query: 385 EEDSSHTLSHSKSESREEQADSESSESLNFSEESPES-PEDENSSSQEGLQSHSSSAESQ 443
+D + E EEQ S + EE E+ P D+ QE + S E Q
Sbjct: 4961 ADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQ 5020
Query: 444 SEES-HSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLK 482
E+ +E S Q + +++ + E ++ E Q K
Sbjct: 5021 VPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGK 5060
Score = 78.6 bits (192), Expect = 1e-14
Identities = 96/496 (19%), Positives = 204/496 (41%), Gaps = 64/496 (12%)
Query: 45 LESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGK---GGDD 101
+E SE +G E + E+ + + SE G D +++ L G + + G DD
Sbjct: 4727 IEMSEDFDGKMHDGELEEQEEDDEKSDSE---GGDLDKHMGDLNGEEADKLDERLWGDDD 4783
Query: 102 KDDDEDDSGDDTFGDDDSGPG----------PKDRQEGGNSRLGSDEDS--DDTIQASEE 149
+++DE++ + T +++GPG D + GNS + ++ +A +
Sbjct: 4784 EEEDEEEEDNKT---EETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEAD 4840
Query: 150 SAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSE 209
QG+D + E R+ D E+ VD + E E+ + D E +G G +
Sbjct: 4841 DGGQGEDKINEQIDE-RDYD-ENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNG-GED 4897
Query: 210 LDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDS------GGSQLLEHP 263
D+E + ++P I+ + AG +++E GE N S G S+ +
Sbjct: 4898 TDNEEGEEENPLEIKE-----KPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAE 4952
Query: 264 SRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKE 323
+ ++ D ++ + ++ E+ +S ++ + + G D QE+ +
Sbjct: 4953 GEEEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEER 5012
Query: 324 NLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDS 383
S E Q + + + EN +Q ++ + + + D++
Sbjct: 5013 EDSDTEEQVPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQ 5072
Query: 384 SEEDSS----------HTLSHSKSESREE-QADSESS---------------ESLNFSEE 417
+E S HT +++S R+ QAD+E S ++ + +E+
Sbjct: 5073 AEGHESNFIAQLASQKHTRKNTQSFKRKPGQADNERSMGDHNERVHKRLRTVDTDSHAEQ 5132
Query: 418 SP-ESPED--ENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSS 474
P + P+ E++ + E ++ S + ++Q+ + S+E ++DS + +E+ ++
Sbjct: 5133 GPAQQPQAQVEDADAFEHIKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEIEDTLMD 5192
Query: 475 SEEDGQLKNIEIESRK 490
+EE + K ++E K
Sbjct: 5193 TEEQEEFKAADVEQLK 5208
Score = 62.4 bits (150), Expect = 1e-09
Identities = 94/519 (18%), Positives = 180/519 (34%), Gaps = 76/519 (14%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQ 82
+++E DSE E+ + E +E+ +E+ D+ E G G D+
Sbjct: 4747 EDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEEDEEEEDNKTEETGPGMDEED 4806
Query: 83 YIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDD 142
+A + +G DK + + DD G G E + R DE+ D
Sbjct: 4807 SEL-VAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQGEDKINEQIDER-DYDENEVD 4864
Query: 143 TIQASEESAPQGQ---------------DSAQDTTSESRELDNEDRVDSKPE-------- 179
++E P+ + + +DT +E E +N + KPE
Sbjct: 4865 PYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDNEEGEEENPLEIKEKPEEAGHEAEE 4924
Query: 180 -GGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIR--SERGNSRMNSAG 236
G T ++ES+ E +G E D G D ++ + E + S
Sbjct: 4925 RGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTGADDQDGDAAQHPEEHSEEQQQSVE 4984
Query: 237 MKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDST 296
K KE+ E + D G E + ++ E +R E + + + ++
Sbjct: 4985 EKDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQVPEALERKE---HASCGQTGVENM 5041
Query: 297 ENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQ 356
+N+ + + + P ++ + + +Q E + + +SQ+ + ++
Sbjct: 5042 QNTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRKP 5101
Query: 357 EEVVSE-SRGDNPD---------PTTSYVEDQ---------EDSDSSE------------ 385
+ +E S GD+ + T S+ E ED+D+ E
Sbjct: 5102 GQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQVEDADAFEHIKQGSDAYDAQ 5161
Query: 386 ------EDSSHTLSHSKSESREEQA-----DSESSESLNFSEESPESPEDENSSSQEGLQ 434
++ + S + EE+ D+E E ++ PE+ S + L
Sbjct: 5162 TYDVASKEQQQSAKDSGKDQEEEEIEDTLMDTEEQEEFKAADVEQLKPEEIKSGTTAPLG 5221
Query: 435 SHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKS 473
E Q+ ++ E+D D + KE N +S
Sbjct: 5222 FDEMEVEIQTVKT---EEDQDPRTDKAHKETENEKPERS 5257
Score = 48.5 bits (114), Expect = 1e-05
Identities = 38/189 (20%), Positives = 82/189 (43%), Gaps = 24/189 (12%)
Query: 317 SQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVE 376
++E ++ + + ++ + P S+S ++ ++N+ E E+ + +E
Sbjct: 4695 NEEQVEDTFQKGQEKDKEDPDSKS----DIKGEDNAIEMSEDFDGKMHDGE-------LE 4743
Query: 377 DQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSH 436
+QE+ D + L + E+AD +E + E++N + + G
Sbjct: 4744 EQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEEDEEEEDNKTEETG---- 4799
Query: 437 SSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEED----GQLK-NIEIESR-- 489
+ + E +++D+ DS +S++ K + E K +E D G+ K N +I+ R
Sbjct: 4800 -PGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQGEDKINEQIDERDY 4858
Query: 490 -KLTVDAYH 497
+ VD YH
Sbjct: 4859 DENEVDPYH 4867
Score = 43.9 bits (102), Expect = 4e-04
Identities = 41/193 (21%), Positives = 73/193 (37%), Gaps = 5/193 (2%)
Query: 319 EDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRG-DNPDPTT-SYVE 376
EDS + E G E ++S Q + E E+ + + D DP + S ++
Sbjct: 4662 EDSAGEGATEFHDYEGGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIK 4721
Query: 377 DQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSH 436
++++ ED + + E +EE + SE + + + +E E L
Sbjct: 4722 GEDNAIEMSEDFDGKMHDGELEEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGD 4781
Query: 437 SSSAESQSEESHSEEDDS---DSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTV 493
E + EE + E+ D +DS +D N S+ ++ Q K E E +
Sbjct: 4782 DDEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADD 4841
Query: 494 DAYHNKPIGDQDD 506
I +Q D
Sbjct: 4842 GGQGEDKINEQID 4854
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 87.8 bits (216), Expect = 2e-17
Identities = 96/455 (21%), Positives = 184/455 (40%), Gaps = 57/455 (12%)
Query: 48 SESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDED 107
++ EG +SE A + ++ Q EG+ G + G G +D E
Sbjct: 1769 AQEREGKTHNSETSAGSELGEAEQEGEGISER----------GETGGQGSGHEDNLQGEA 1818
Query: 108 DSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRE 167
+G GD D PG D EG + + + + ++ AP+ + AQ+ E++
Sbjct: 1819 AAG----GDQD--PGQSDGAEGIEA---PEAEGEAQPESEGVEAPEAEGDAQEAEGEAQP 1869
Query: 168 LDNEDRVDSKPEGGDSTQESES----EEHWVGGGSDGESSHGDGSELDDEGMQSDDPESI 223
++ED V++ G++ ESE E W ES + E + E +
Sbjct: 1870 -ESED-VEAPEAEGEAQPESEDVETPEAEWE---VQPESEGAEAPEAEKEAQPETESVEA 1924
Query: 224 RSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELD 283
G S G +++E+ E +++A Q S+++E S+ +EE+ + E +
Sbjct: 1925 LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIE---------SQEAEEEAQPESE 1975
Query: 284 DNNTME-EVKSDSTENSNSRDT-GLSQPRRDSKGDSQEDSKENLSQ------------EE 329
D +E EV++ E ++ + P +++G+ QE +E + EE
Sbjct: 1976 DVEALEVEVETQEAEGEAQPESEDVEAP--EAEGEMQEAEEEAQPESDGVEAQPKSEGEE 2033
Query: 330 SQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSS 389
+Q V+G + ++ +A S + EE E+ G+ + + ED D+ E +
Sbjct: 2034 AQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGE 2093
Query: 390 HTLSHSKSESREEQADSESSESLNFSEESPES-PEDENSSSQEG---LQSHSSSAESQSE 445
E+ E + +++ +E + E E+ PE E + E Q S E+Q
Sbjct: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDA 2153
Query: 446 ESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ 480
E ++ + + +E E + E +G+
Sbjct: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGE 2188
Score = 81.6 bits (200), Expect = 2e-15
Identities = 98/508 (19%), Positives = 202/508 (39%), Gaps = 70/508 (13%)
Query: 22 YQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDH 81
+ + E+ + K H T ++ +E G +S + D + + + L D
Sbjct: 1700 HTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLS--QGPGVDEGEDGEGSQRLNRDKD 1757
Query: 82 QYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSD 141
+ G +G + E +G + + G G +R E G G +++
Sbjct: 1758 PKLGEAEGDAMAQEREG--KTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQ 1815
Query: 142 DTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSK----PEGGDSTQESESEEHWVGGG 197
A + P D A+ E+ E + E + +S+ PE QE+E E
Sbjct: 1816 GEAAAGGDQDPGQSDGAEGI--EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESED 1873
Query: 198 SDGESSHGDGS-------------ELDDEGMQSDDPESIRSER------------GNSRM 232
+ + G+ E+ E ++ PE+ + + G
Sbjct: 1874 VEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEP 1933
Query: 233 NSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTME-EV 291
S G +++E+ E +++A Q S+++E S+ +EE+ + E +D +E EV
Sbjct: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIE---------SQEAEEEAQPESEDVEALEVEV 1984
Query: 292 KSDSTE-NSNSRDTGLSQPRRDSKGDSQEDSKENLSQ------------EESQNVDGPSS 338
++ E + + P +++G+ QE +E + EE+Q V+G +
Sbjct: 1985 ETQEAEGEAQPESEDVEAP--EAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQ 2042
Query: 339 ESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSE 398
++ +A S + EE E+ G+ + + ED D+ E + E
Sbjct: 2043 KTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVE 2102
Query: 399 SREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQD 458
+ E + +++ +E + E+PE+ E E EG+++ + E+Q E E D++ +
Sbjct: 2103 APEAEGEAQKAEGI----EAPET-EGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGE- 2156
Query: 459 SSRSKEDSNSTESKSSSEE-DGQLKNIE 485
++ +S E++ + EE +L+ +E
Sbjct: 2157 ---AQPESEGIEAQEAEEEAQPELEGVE 2181
Score = 75.9 bits (185), Expect = 8e-14
Identities = 97/457 (21%), Positives = 195/457 (42%), Gaps = 47/457 (10%)
Query: 26 ESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEE-QANEDPSDSTQSEEGLGSDDHQYI 84
E+E + + +AP ++ E+ ++ SE+ +A E ++ E + + + ++
Sbjct: 1839 EAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWE 1898
Query: 85 YRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDD---SGPGPKDRQEGGNSRLGSDEDSD 141
+ + + + + + E +T G+D+ G ++ +E G +
Sbjct: 1899 VQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPES 1958
Query: 142 DTIQ---ASEESAPQGQD-SAQDTTSESRELDNEDRVDSK----PEGGDSTQESESEEHW 193
+ I+ A EE+ P+ +D A + E++E + E + +S+ PE QE+E E
Sbjct: 1959 EVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ- 2017
Query: 194 VGGGSDGESSHGDGSELDDEGMQSDDPES-IRSERGNSRMNSAGMKSKESGENSEQAN-- 250
S G ++ EG ++ + E + G+++ S G+++ E+ E +++A
Sbjct: 2018 -------PESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGE 2070
Query: 251 TQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEE--VKSDSTENSNSRDTGLSQ 308
Q++ G HP SE+ D E + E V++ E + G+
Sbjct: 2071 VQEAEGEA---HPE---------SEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEA 2118
Query: 309 PRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNP 368
P +++G++Q +S E + E++ P SE EA + E ES E + ++ +
Sbjct: 2119 P--ETEGEAQPES-EGIEAPEAEGEAQPESEGV-EAQDAEGEAQPES-EGIEAQEAEEEA 2173
Query: 369 DPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSS 428
P VE E ++ + S + ++E E Q + E E+ EE+ PE +
Sbjct: 2174 QPELEGVEAPE-AEGEAQPESEGIEAPEAEG-EAQPELEGVEAPEAEEEAQPEPEGVETP 2231
Query: 429 SQEGLQSHSSSAESQSEESHSEE---DDSDSQDSSRS 462
EG S E+Q E+ S + D S+++S S
Sbjct: 2232 EAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASES 2268
Score = 67.4 bits (163), Expect = 3e-11
Identities = 85/360 (23%), Positives = 145/360 (40%), Gaps = 63/360 (17%)
Query: 136 SDEDSDDTIQASEE------SAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESES 189
+D S T+Q +E S G D +D R ++D + EG QE E
Sbjct: 1715 TDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREG 1774
Query: 190 EEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQA 249
+ H S GSEL G + E I SERG + +G + GE +
Sbjct: 1775 KTH--------NSETSAGSEL---GEAEQEGEGI-SERGETGGQGSGHEDNLQGEAA--- 1819
Query: 250 NTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQP 309
+GG Q D + D +E +++ S G+ P
Sbjct: 1820 ----AGGDQ-------------------DPGQSDGAEGIEAPEAEGEAQPESE--GVEAP 1854
Query: 310 RRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPD 369
+++GD+QE E +Q ES++V+ P +E + S + E++ EV ES G +
Sbjct: 1855 --EAEGDAQEAEGE--AQPESEDVEAPEAEGEAQPE-SEDVETPEAEWEVQPESEG--AE 1907
Query: 370 PTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSS 429
+ E Q +++S E + +SE E Q E+++ + PES E+ +
Sbjct: 1908 APEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAE-GQTQPESEVIESQEA 1966
Query: 430 QEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESR 489
+E Q S E+ E ++E + ++Q S E + E +G+++ E E++
Sbjct: 1967 EEEAQPESEDVEALEVEVETQEAEGEAQPESEDVE---------APEAEGEMQEAEEEAQ 2017
Score = 63.2 bits (152), Expect = 6e-10
Identities = 67/305 (21%), Positives = 116/305 (38%), Gaps = 18/305 (5%)
Query: 200 GESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQL 259
GE + G+ +E+ G DP S R+ +G G+ + E D GSQ
Sbjct: 1698 GEHTDGEAAEVAP-GKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGE-----DGEGSQR 1751
Query: 260 LEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQE 319
L +R K +E D ++ + T S +E + G R G
Sbjct: 1752 L---NRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGS 1808
Query: 320 DSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEV----VSESRGDNPDPTTSYV 375
++NL E + D +S + + E E+Q E E+ GD +
Sbjct: 1809 GHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQ 1868
Query: 376 EDQEDSDSSEEDSSHTLSHSKSESREE----QADSESSESLNFSEESPESPEDENSSSQE 431
+ ED ++ E + E+ E Q +SE +E+ +E+ E + E
Sbjct: 1869 PESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETE 1928
Query: 432 GL-QSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRK 490
G + S AE+Q E ++E + +Q S E + E ED + +E+E+++
Sbjct: 1929 GEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQE 1988
Query: 491 LTVDA 495
+A
Sbjct: 1989 AEGEA 1993
Score = 38.1 bits (87), Expect = 0.019
Identities = 90/470 (19%), Positives = 167/470 (35%), Gaps = 46/470 (9%)
Query: 46 ESSESSEGSKVSSEEQANEDPSDSTQSE---------EGLGSDDHQYIYRLAGGFSRSTG 96
E + S G EE + PS +S + + + Y LA +TG
Sbjct: 925 EKTLRSGGGPQGQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELA---DETTG 981
Query: 97 KGGDDKDDDEDDSGDDT----FGDD--------DSGPGPKDRQEGGNSRLGSDEDSDDTI 144
G E D GDD G+ + PG EG + LGS + +
Sbjct: 982 AAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQDPEPEG--ALLGSSDTGPQSG 1039
Query: 145 QASEE-SAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESS 203
+ + +AP+G A RE RV + G + ++ +G S
Sbjct: 1040 EGVPQGAAPEGVSEAPAEAGADREAPAGCRVSLRALPGRVSASTQIMRALMG------SK 1093
Query: 204 HGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHP 263
G S + + S + + + S + ++ G + + +DS Q L
Sbjct: 1094 QGRPSSVPEVSRPMARRLSCSAGALITCLASLQLFEEDLGSPASKVRFKDSPRYQELLSI 1153
Query: 264 SRKIFRKSRISEEDDRS---ELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQED 320
S+ ++ + E+ S EL + + ++ S + + + + G S E
Sbjct: 1154 SKDLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMTENFTPTSSSGVDISSGSGGSGES 1213
Query: 321 SKENLSQEE--SQNVDGPSSESSQEANLSSQENSS--ESQEEVVSESRGDNPDPTTSYVE 376
S +Q + P S+Q + + E+ E+Q++ + + + E
Sbjct: 1214 SVPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNE 1273
Query: 377 DQEDSDSSEEDSSHTLSHSKSESREEQAD-SESSESLNFSEESPESPEDENSSSQEGLQS 435
D+ + DS E+ +S L + +E+ E+ E E+ + E + ++EGLQ
Sbjct: 1274 DEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQE 1333
Query: 436 HSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIE 485
E E E + Q+ E+ T + EE QL+ ++
Sbjct: 1334 -----EGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVK 1378
Score = 37.4 bits (85), Expect = 0.033
Identities = 38/178 (21%), Positives = 65/178 (36%), Gaps = 20/178 (11%)
Query: 275 EEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVD 334
E + + ++ +EE++ E L + + +G Q ++ E +EE +
Sbjct: 1343 ETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEE 1402
Query: 335 G-----PSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSS 389
G SE+S SQE+ +EE S P P E ++ E S
Sbjct: 1403 GSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPA-------EGTEEPTEPPS 1455
Query: 390 HTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEES 447
H LS + + E Q+ S+ L E P QE Q+ + ++ S
Sbjct: 1456 H-LSETDPSASERQSGSQLEPGL-------EKPPGATMMGQEHTQAQPTQGAAERSSS 1505
Score = 32.0 bits (71), Expect = 1.4
Identities = 39/192 (20%), Positives = 68/192 (35%), Gaps = 23/192 (11%)
Query: 305 GLSQPRRDSKGDSQEDSKENLSQEESQNV---DGPSSESSQEANLSSQENSSESQEEVVS 361
GL P + + + S+E S + S + +G S + + + SQ+E +
Sbjct: 511 GLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGRPQGCPGKARAETSQQE--A 568
Query: 362 ESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPES 421
GD P S + D +E T + + E S ++ E S
Sbjct: 569 SEGGDPASPALSLSSLRSDDLQAETQGQGTEQATGAAVTREPL--VLGLSCSWDSEGASS 626
Query: 422 PEDENSSSQEGLQSHSSSAESQS----------------EESHSEEDDSDSQDSSRSKED 465
+SSQ+G + H S A + S SH +D DSS +K+
Sbjct: 627 TPSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVAPRGHPRHSHYRKDTHSPLDSSVTKQV 686
Query: 466 SNSTESKSSSEE 477
E + + ++
Sbjct: 687 PRPPERRRACQD 698
Score = 31.2 bits (69), Expect = 2.4
Identities = 28/150 (18%), Positives = 61/150 (40%), Gaps = 7/150 (4%)
Query: 116 DDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVD 175
+D++ ++++ N ++ + +Q E + Q+ + E E+ +
Sbjct: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
Query: 176 SKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDD----PE-SIRSERGNS 230
+ + T+E+E E E G L +EG+Q ++ PE ++ E
Sbjct: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEE 1392
Query: 231 RMNSAGMKSKES--GENSEQANTQDSGGSQ 258
+ G+ + S G+ +A++ D GSQ
Sbjct: 1393 GLKEEGLPEEGSVHGQELSEASSPDGKGSQ 1422
Score = 30.4 bits (67), Expect = 4.0
Identities = 35/153 (22%), Positives = 57/153 (37%), Gaps = 29/153 (18%)
Query: 144 IQASEESAPQGQDSAQDTTSESRELDNE---------DRVDSKPEGG---DSTQESESEE 191
++ ++E+ +GQ + E E E + V PEGG ++ +E EE
Sbjct: 1338 LEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEE 1397
Query: 192 HWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANT 251
GS + S D +G Q DDP ++ +E+G S A
Sbjct: 1398 GLPEEGSVHGQELSEASSPDGKGSQEDDP----------------VQEEEAGRASASAEP 1441
Query: 252 QDSGGS-QLLEHPSRKIFRKSRISEEDDRSELD 283
+ G+ + E PS SE S+L+
Sbjct: 1442 CPAEGTEEPTEPPSHLSETDPSASERQSGSQLE 1474
>gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homolog
[Homo sapiens]
Length = 666
Score = 85.1 bits (209), Expect = 1e-16
Identities = 86/373 (23%), Positives = 148/373 (39%), Gaps = 48/373 (12%)
Query: 67 SDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGD----DTFGDDDSGPG 122
S++ + + GSD A G S G + D+ DSG + FGDD
Sbjct: 14 SEAERKDSDSGSDSDSDQENAASG---SNASGSESDQDERGDSGQPSNKELFGDD----- 65
Query: 123 PKDRQEGGNSRLGSD---EDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDS-KP 178
EG + GSD E SD+ +ASE S + D + E N+D + +
Sbjct: 66 --SEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRS 123
Query: 179 EGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMK 238
+GG E+E GS+ S + +D+ QSDD + S+ S K
Sbjct: 124 DGGSHHSEAE--------GSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDK 175
Query: 239 SKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTEN 298
+ S ++ + NT D QL + +++ + + + +D+R DN+ E
Sbjct: 176 LQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDND---------DEK 226
Query: 299 SNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEE 358
NS D Q + K + +D + S EE ++ S + ++ + S S+S++E
Sbjct: 227 QNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRH----SDDEEEQDHKSESARGSDSEDE 282
Query: 359 VVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEES 418
V+ R + S E D++ +++S ++ +D E +
Sbjct: 283 VLRMKR---KNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGED------KPPT 333
Query: 419 PESPEDENSSSQE 431
P P DEN Q+
Sbjct: 334 PGQPVDENGLPQD 346
Score = 84.7 bits (208), Expect = 2e-16
Identities = 87/401 (21%), Positives = 157/401 (39%), Gaps = 54/401 (13%)
Query: 111 DDTFGDD-DSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELD 169
+D FG D DS KD S GSD DSD AS +A G +S QD +S +
Sbjct: 5 EDLFGSDADSEAERKD------SDSGSDSDSDQENAASGSNA-SGSESDQDERGDSGQPS 57
Query: 170 NEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGN 229
N++ E ++ S S+ H S+ + + SE D + +DP + G+
Sbjct: 58 NKELFGDDSEDEGASHHSGSDNH-----SERSDNRSEASERSDH--EDNDPSDVDQHSGS 110
Query: 230 SRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTME 289
E+ + E + GGS E +E +++ DD
Sbjct: 111 -----------EAPNDDEDEGHRSDGGSHHSE------------AEGSEKAHSDDEKWGR 147
Query: 290 EVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQ 349
E KSD +++ +++ + + S D ++S ++ + + + + P + LS +
Sbjct: 148 EDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEE 207
Query: 350 ENSSESQEEVVS-------ESRGDNPDPTTSYVEDQEDSD-----SSEEDSSHTLSHSKS 397
E ++ E V+ ++ D P S E ++SD +S+E+ H+ +
Sbjct: 208 EKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQ 267
Query: 398 ESREEQADSESSES--LNFSEESPESPEDENSSSQEGLQSHSSSAE--SQSEESHSEEDD 453
+ + E A SE L ++ + + E S E + +S + + +++ S D
Sbjct: 268 DHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDG 327
Query: 454 SDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVD 494
D + D N EE IE+E K+ D
Sbjct: 328 EDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTD 368
Score = 66.6 bits (161), Expect = 5e-11
Identities = 52/198 (26%), Positives = 95/198 (47%), Gaps = 29/198 (14%)
Query: 326 SQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSE 385
S+ E ++ D S S + N +S N+S S+ + + RGD+ P+ ++ DS +
Sbjct: 14 SEAERKDSDSGSDSDSDQENAASGSNASGSESD--QDERGDSGQPSN---KELFGDDSED 68
Query: 386 EDSSHTLSHSKSESREEQAD--SESSESLNFSE------------ESPESPEDENSSSQE 431
E +SH HS S++ E++D SE+SE + + E+P EDE S
Sbjct: 69 EGASH---HSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDG 125
Query: 432 GLQSHSSSAESQSEESHSEEDDSDSQDSSRSKED----SNSTESKSSSEEDGQLKNIEIE 487
G SH S AE SE++HS+++ +D S +D ++ E ++ ++ +L+N + +
Sbjct: 126 G--SHHSEAEG-SEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDD 182
Query: 488 SRKLTVDAYHNKPIGDQD 505
+ D + D +
Sbjct: 183 EKMQNTDDEERPQLSDDE 200
Score = 59.7 bits (143), Expect = 6e-09
Identities = 68/310 (21%), Positives = 121/310 (39%), Gaps = 63/310 (20%)
Query: 28 EDSE-EWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQ-SEEGLGSDDHQYIY 85
+DSE E H + + S SE S+ S E + DPSD Q S +DD +
Sbjct: 64 DDSEDEGASHHSGSDNHSERSDNRSEASERSDHE--DNDPSDVDQHSGSEAPNDDEDEGH 121
Query: 86 RLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQ 145
R GG S +G + D++ G + D+ + + + D ++ Q
Sbjct: 122 RSDGGSHHSEAEGSEKAHSDDEKWGRE------------DKSDQSDDEKIQNSDDEERAQ 169
Query: 146 ASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHG 205
S+E Q D + + + D+E+R P+ D ++ SEE
Sbjct: 170 GSDEDKLQNSDDDE----KMQNTDDEER----PQLSDDERQQLSEE-------------- 207
Query: 206 DGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSR 265
E SDD + S+ + + NS + + + + N+ D
Sbjct: 208 -------EKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDD------------ 248
Query: 266 KIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDS-KGDSQEDSKEN 324
+ + S+E+ R D+ ++ KS+S S+S D L R+++ DS+ DS
Sbjct: 249 ---ERPQASDEEHRH--SDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTE 303
Query: 325 LSQEESQNVD 334
+ ++ S +D
Sbjct: 304 VPKDNSGTMD 313
Score = 48.9 bits (115), Expect = 1e-05
Identities = 108/552 (19%), Positives = 203/552 (36%), Gaps = 126/552 (22%)
Query: 19 VTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGS 78
V ++ +E+ + +E +GH + + E+ E SE + E+ ED SD + E+ S
Sbjct: 104 VDQHSGSEAPNDDEDEGHRSDGGSHHSEA-EGSEKAHSDDEKWGREDKSDQSDDEKIQNS 162
Query: 79 DDHQYIYRLAGGFSRSTGKGGDDK-----DDDE-----DD-----SGDDTFGDDDSGPGP 123
DD + R G DD+ DD+E DD S ++ DD P
Sbjct: 163 DDEE---RAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVA 219
Query: 124 KDRQEGGNSRLGSDEDS------DDTIQASEESAPQGQDSA---------QDTTSES-RE 167
D + + SD++ ++ +Q S++ PQ D QD SES R
Sbjct: 220 SDNDD---EKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARG 276
Query: 168 LDNEDRV-----------DSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSE------- 209
D+ED V DS+ + + S + GG+D SS DG +
Sbjct: 277 SDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQ 336
Query: 210 -LDDEGMQSDDPES--------------IRSERGNSR--MNSAGMKSKESGENSEQANTQ 252
+D+ G+ D E + ++ GN + S E Q
Sbjct: 337 PVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYED 396
Query: 253 DSGGSQLLEHPSRKIFR-------KSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTG 305
+ ++L+ R + + RI +++ +E+ ++N SD + + + +
Sbjct: 397 EFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEV 456
Query: 306 LSQPRRDSKGDSQEDSKENLSQEESQNV---------DGPSSESSQEANLSSQENSSESQ 356
+ +GD + + Q V S + ++ LS + S++Q
Sbjct: 457 FDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQ 516
Query: 357 EEVVSESRGDNPD-PTTSYVEDQEDSDSS------------EEDSSHTLSHSKSESREEQ 403
+ + G +P+ T ++ +E+ + E+ LS S E
Sbjct: 517 KIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYD 576
Query: 404 ADSESSESLN-------------------FSEESPESPEDENSSSQEGLQSHSSSAESQS 444
+ E ES++ +S +S E E++ + Q L++ +++ +
Sbjct: 577 EEEEGEESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKA--QRLLKAKKLTSDEEG 634
Query: 445 EES---HSEEDD 453
E S +E+DD
Sbjct: 635 EPSGKRKAEDDD 646
Score = 38.1 bits (87), Expect = 0.019
Identities = 35/138 (25%), Positives = 53/138 (38%), Gaps = 17/138 (12%)
Query: 377 DQEDSDSSEEDSSHTL--SHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 434
D ED S+ DS S S S+S +Q ++ S + + SE + D S + L
Sbjct: 3 DMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELF 62
Query: 435 SHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVD 494
S E S S S D+ + D+ S S+ S ED +++ S
Sbjct: 63 GDDSEDEGASHHSGS--------DNHSERSDNRSEASERSDHEDNDPSDVDQHSGS---- 110
Query: 495 AYHNKPIGDQDDNDCQDG 512
P D+D+ DG
Sbjct: 111 ---EAPNDDEDEGHRSDG 125
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 80.5 bits (197), Expect = 3e-15
Identities = 68/266 (25%), Positives = 120/266 (45%), Gaps = 28/266 (10%)
Query: 227 RGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNN 286
RG R+ S +K KE + + S G Q PS + + EED+ SE + +
Sbjct: 954 RGAIRLPSFKVKRKEPPDTT-------SSGDQKRLRPS------TSVDEEDEESERERDR 1000
Query: 287 TMEEVKSDSTENSNSRDTGLSQPRRDSKGDS--QEDSKENLSQEESQNVDGPSSESSQEA 344
M + + + +P R + DS +ED KE+LS+E+ + +E +E
Sbjct: 1001 DMADTPCELAKRDPKGVGVRRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEE- 1059
Query: 345 NLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQA 404
+E+ + + ES D+ D S ++++ DS EE++ ++ SK+E+
Sbjct: 1060 ----EEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIVT-SKAEATSSSE 1114
Query: 405 DSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEED--DSDSQDSSRS 462
SESSE + SE SP S EDE E + + E + EE +EE + +D +
Sbjct: 1115 SSESSEFESSSESSPSSSEDE-----EEVVAREEEEEEEEEEMVAEESMASAGPEDFEQD 1169
Query: 463 KEDSNSTESKSSSEEDGQLKNIEIES 488
E++ + + G + ++IE+
Sbjct: 1170 GEEAALAPGAPAVDSLGMEEEVDIET 1195
Score = 55.5 bits (132), Expect = 1e-07
Identities = 86/411 (20%), Positives = 152/411 (36%), Gaps = 65/411 (15%)
Query: 31 EEW---KGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRL 87
+EW K +A+A P++S E + + +++ +S EGLG + L
Sbjct: 894 DEWWDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGL 953
Query: 88 AGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQAS 147
G + K + D SGD P +E S D D DT
Sbjct: 954 RGAIRLPSFKVKRKEPPDTTSSGDQK----RLRPSTSVDEEDEESERERDRDMADTPCEL 1009
Query: 148 EESAPQGQDSAQDTTSESRELDN---EDRVDSKPEGGDSTQESESEEHWVGGGSDGESSH 204
+ P+G + + ELD+ ED +S E +ST+E E E
Sbjct: 1010 AKRDPKGV-GVRRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEE------------ 1056
Query: 205 GDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPS 264
+ E DD+ SDD + ++ ++ ++ A K + + E + S
Sbjct: 1057 -EEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIVTSKA-------- 1107
Query: 265 RKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKEN 324
+ SE + SE + ++ S+ E +R+ + +E+ +E
Sbjct: 1108 ----EATSSSESSESSEFESSSESSPSSSEDEEEVVARE------------EEEEEEEEE 1151
Query: 325 LSQEESQNVDGPS--SESSQEANLSSQENSSES---QEEVVSESRGDNPDPTTSYVED-- 377
+ EES GP + +EA L+ + +S +EEV E+ P+ S +++
Sbjct: 1152 MVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPP 1211
Query: 378 -----QEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPE 423
+E +DS E LS + + ++ E+ P SPE
Sbjct: 1212 LPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEA-----RPPLSPE 1257
Score = 30.0 bits (66), Expect = 5.3
Identities = 26/128 (20%), Positives = 55/128 (42%), Gaps = 26/128 (20%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQ 82
+ +E + EE + + SSESSE S+ S +++ PS S EE + ++
Sbjct: 1088 EKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESS--PSSSEDEEEVVAREE-- 1143
Query: 83 YIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKD-RQEGGNSRLGSDEDSD 141
++++++E+ +++ + GP+D Q+G + L +
Sbjct: 1144 -----------------EEEEEEEEMVAEESM----ASAGPEDFEQDGEEAALAPGAPAV 1182
Query: 142 DTIQASEE 149
D++ EE
Sbjct: 1183 DSLGMEEE 1190
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 79.3 bits (194), Expect = 8e-15
Identities = 109/534 (20%), Positives = 212/534 (39%), Gaps = 66/534 (12%)
Query: 23 QNNESE-DSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDH 81
+NNE E S++ K + + ++S E S+ + P S GSDD
Sbjct: 85 ENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYS----GSDDD 140
Query: 82 QYIYRL---AGGFSRSTGKGGDDKDDDED---------------DSGDDTFGDDDSGPGP 123
+L A G ++ + K D ++DED +SGD++ S G
Sbjct: 141 DDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQ 200
Query: 124 KDRQE---GGNSRLGSDEDSDD-----TIQASEESAPQGQDSAQDTTSESRELDNEDRVD 175
K Q+ G N G+++D Q E + + + ++ R+L ++ ++
Sbjct: 201 KKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELE 260
Query: 176 SKPEGGDSTQESES--EEHWVGGGSDGESSHGDGSELDDEGMQS--DDPESIRSERGNSR 231
+ + +ES+ EE V ++ SE E + DD E + ++
Sbjct: 261 TGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKD--- 317
Query: 232 MNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEV 291
K K+ GE E+ + G S+ ++ K + EE++R + ++ ++ +
Sbjct: 318 ------KKKKKGEKEEKEKEKKKGPSKATVKAMQEALAK--LKEEEERQKREEEERIKRL 369
Query: 292 KSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQE-----ESQNVDGPSSESS----Q 342
+ E + L Q +R+ K +++ KE L +E +SQ +E++ Q
Sbjct: 370 --EELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQ 427
Query: 343 EANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREE 402
+ S ++ + E + P +E +E S+S E ++ + +EE
Sbjct: 428 AQGVEVPSKDSLPKKRPIYEDKKRKKIP--QQLESKEVSESMELCAAVEVMEQGVPEKEE 485
Query: 403 QADSESSESLNFSEES-----PESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQ 457
E +E++ DE + EG + H E+ EE EE++ + +
Sbjct: 486 TPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDE 545
Query: 458 DSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQD 511
+S +E+ +E EED ++ + E +S K T+D +K + + D D
Sbjct: 546 ESEEEEEEEGESEGSEGDEEDEKVSD-EKDSGK-TLDKKPSKEMSSDSEYDSDD 597
Score = 53.9 bits (128), Expect = 3e-07
Identities = 56/309 (18%), Positives = 123/309 (39%), Gaps = 28/309 (9%)
Query: 228 GNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNT 287
G + N + +K+ + A + G+ + P + +K + ++ D E D
Sbjct: 2 GKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKE 61
Query: 288 MEEVKSDSTENSNSRDTGLSQP---------RRDSKGDSQEDSKENLSQEESQNVDGPSS 338
+EE+ ++ R+T +P +D K Q+ K++ +S+ ++ S
Sbjct: 62 LEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS 121
Query: 339 ESSQEA----NLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSH 394
+S + A + S + + ++ +++G + +ED D+S++ + +
Sbjct: 122 KSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRIN 181
Query: 395 SKSESREEQAD------SESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESH 448
S ES +E + + N + ES +++ +S + AE + E
Sbjct: 182 SSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERK 241
Query: 449 SEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLK-NIEIESRKLTVD-----AYHNK--- 499
+++ + KE+ + + S +++ Q K E K+TVD A K
Sbjct: 242 KRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAET 301
Query: 500 PIGDQDDND 508
P +DDN+
Sbjct: 302 PTAAEDDNE 310
>gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens]
Length = 755
Score = 76.3 bits (186), Expect = 6e-14
Identities = 81/394 (20%), Positives = 155/394 (39%), Gaps = 52/394 (13%)
Query: 142 DTIQASEESAPQGQDSAQDTTSESRELDNEDRVD---SKPEGGDSTQESESEEHWVGGGS 198
D++ ASE + P + S S+ E +P +++E + G S
Sbjct: 386 DSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGAS 445
Query: 199 DGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQ 258
+ + + +EG + E +RG S K E G N + + +DS
Sbjct: 446 ENNAKESSPEKEAEEGCPEKESEEGCPKRGFE--GSCSQKESEEG-NPVRGSEEDS---- 498
Query: 259 LLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQ 318
P ++ +K+ +++ ++N +E + D + S + + + DS+
Sbjct: 499 ----PKKESKKKTL------KNDCEENGLAKESEDDLNKESEEE---VGPTKESEEDDSE 545
Query: 319 EDSKENLSQEESQN-VDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVED 377
++S E+ S+++S++ + E+ E +L + + E E V+ + +N + + +D
Sbjct: 546 KESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDD 605
Query: 378 QEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHS 437
+ EE S E EE+ E F +ES E EDE + ++GL++
Sbjct: 606 GSEKVLDEEGSEREFDEDSDEKEEEEDTYEKV----FDDESDEK-EDEEYADEKGLEAAD 660
Query: 438 SSAE--SQSEESHSEEDDSDSQDSSRSK---------EDSNSTESKSSSEEDGQLKNIEI 486
AE E+ E DD + +D+ + ED +S E EED K +
Sbjct: 661 KKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDD 720
Query: 487 ESRKLTVDAYHNKPIG------------DQDDND 508
+ T+ + + G D DD+D
Sbjct: 721 SDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
Score = 66.6 bits (161), Expect = 5e-11
Identities = 81/367 (22%), Positives = 145/367 (39%), Gaps = 72/367 (19%)
Query: 12 GLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQ 71
G++ P+ + ++ED E+ E S +K SS E+ E+ +
Sbjct: 419 GMAFEEPIDEKKFEKTEDGGEF------------EEGASENNAKESSPEKEAEEGCPEKE 466
Query: 72 SEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGN 131
SEEG GF S + E + G+ G ++ P ++E
Sbjct: 467 SEEGCPKR----------GFEGSCSQ-------KESEEGNPVRGSEEDSP----KKESKK 505
Query: 132 SRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEE 191
L +D + + + SE+ + + T ES E D+ E ES+E
Sbjct: 506 KTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDS---------------EKESDE 550
Query: 192 HWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGEN-SEQAN 250
S+ +S G E ++ G++ D E G+ + + KE EN SE +
Sbjct: 551 DC----SEKQSEDGSEREFEENGLEKD-----LDEEGSEKELHENVLDKELEENDSENSE 601
Query: 251 TQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSR----DTGL 306
+D G ++L+ R +ED + ++ +T E+V D ++ + GL
Sbjct: 602 FEDDGSEKVLDEEG-----SEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGL 656
Query: 307 -SQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSE---SQEEVVSE 362
+ ++ +GD+ E E +E ++ DG E + E L ++S+E +EE SE
Sbjct: 657 EAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADE-KLFEDDDSNEKLFDEEEDSSE 715
Query: 363 SRGDNPD 369
D+ D
Sbjct: 716 KLFDDSD 722
Score = 66.2 bits (160), Expect = 7e-11
Identities = 79/393 (20%), Positives = 149/393 (37%), Gaps = 46/393 (11%)
Query: 136 SDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVG 195
+D ++T + EE +G ++ + +R L D V + G S SE
Sbjct: 351 TDYQVEETSREREERL-RGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTS 409
Query: 196 GGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSG 255
+ E++ G E E I ++ + + S N+++++ +
Sbjct: 410 KMNAQETATGMAFE-----------EPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEA 458
Query: 256 GSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKG 315
E S + K + E ++ N + + DS + + + T + +
Sbjct: 459 EEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLA 518
Query: 316 DSQEDSKENLSQEESQNVDGPSSESSQE-ANLSSQENSSESQEEVVSESRGDNPDPTTSY 374
ED S+EE GP+ ES ++ + S E+ SE Q E SE +
Sbjct: 519 KESEDDLNKESEEEV----GPTKESEEDDSEKESDEDCSEKQSEDGSERE---------F 565
Query: 375 VEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 434
E+ + D EE S L + + E+ DSE+SE F ++ E DE S +E +
Sbjct: 566 EENGLEKDLDEEGSEKELHENVLDKELEENDSENSE---FEDDGSEKVLDEEGSEREFDE 622
Query: 435 SHSSSAESQSEESHSEEDDSDSQD------------SSRSKEDSNS-----TESKSSSEE 477
E + +D+SD ++ + + E+ ++ ES +E
Sbjct: 623 DSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDE 682
Query: 478 DGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQ 510
D K +E KL D N+ + D++++ +
Sbjct: 683 DADGKEVEDADEKLFEDDDSNEKLFDEEEDSSE 715
Score = 56.2 bits (134), Expect = 7e-08
Identities = 62/228 (27%), Positives = 93/228 (40%), Gaps = 21/228 (9%)
Query: 26 ESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIY 85
ESED + PT E +S + S E+ +ED S+ E GL D +
Sbjct: 520 ESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDE--- 576
Query: 86 RLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQ 145
G + + DK+ +E+DS + F DD S K E G+ R DEDSD+ +
Sbjct: 577 ---EGSEKELHENVLDKELEENDSENSEFEDDGS---EKVLDEEGSER-EFDEDSDEK-E 628
Query: 146 ASEESAPQGQDSAQDTTSESRELDNE--DRVDSKPEGGDST----QESESEEHWVGGGSD 199
E++ + D D + D + + D K E GD+ +ES+ +E G +
Sbjct: 629 EEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKE 688
Query: 200 GESSHGDGSELDDEGMQSDDPESIRSER----GNSRMNSAGMKSKESG 243
E + E DD + D E SE+ + R G S E G
Sbjct: 689 VEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEEG 736
Score = 53.5 bits (127), Expect = 4e-07
Identities = 63/353 (17%), Positives = 130/353 (36%), Gaps = 24/353 (6%)
Query: 175 DSKPEGGDSTQESESEE----------HWVGGGSDGESSHGDGSELDDEGMQSDDPESIR 224
D P+G S + EE W GG + ++ E + E +R
Sbjct: 308 DRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSREREERLR 367
Query: 225 SERG--NSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSEL 282
N+ + G++ +S SE+A S EHPS S+++ ++ + +
Sbjct: 368 GWEAFLNAPEANRGLRRSDSVSASERAGP--SRARHFSEHPST-----SKMNAQETATGM 420
Query: 283 DDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQ 342
++E K + TE+ + G S+ + +++++E ++ES+
Sbjct: 421 AFEEPIDEKKFEKTEDGGEFEEGASE-NNAKESSPEKEAEEGCPEKESEEGCPKRGFEGS 479
Query: 343 EANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREE 402
+ S+E + E S + + E+ + SE+D + ++E
Sbjct: 480 CSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKES 539
Query: 403 QADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHS----EEDDSDSQD 458
+ D ES E E + GL+ S+ E + E +++DS++
Sbjct: 540 EEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSEN 599
Query: 459 SSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQD 511
S + S + SE + + E E + T + + +++D + D
Sbjct: 600 SEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYAD 652
Score = 36.2 bits (82), Expect = 0.073
Identities = 39/157 (24%), Positives = 62/157 (39%), Gaps = 10/157 (6%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEE-----GLG 77
+N+E ED K + + + + + E+ +D SD + EE GL
Sbjct: 598 ENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLE 657
Query: 78 SDDHQYIYRLAGG--FSRSTGKGGDDKDDDEDDSGDDT-FGDDDSGPGPKDRQEGGNSRL 134
+ D + A F S K +D D E + D+ F DDDS D +E + +L
Sbjct: 658 AADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKL 717
Query: 135 GSDEDSDDTIQ--ASEESAPQGQDSAQDTTSESRELD 169
D D T+ S E P S+ +S+ + D
Sbjct: 718 FDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
>gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens]
Length = 755
Score = 76.3 bits (186), Expect = 6e-14
Identities = 81/394 (20%), Positives = 155/394 (39%), Gaps = 52/394 (13%)
Query: 142 DTIQASEESAPQGQDSAQDTTSESRELDNEDRVD---SKPEGGDSTQESESEEHWVGGGS 198
D++ ASE + P + S S+ E +P +++E + G S
Sbjct: 386 DSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGAS 445
Query: 199 DGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQ 258
+ + + +EG + E +RG S K E G N + + +DS
Sbjct: 446 ENNAKESSPEKEAEEGCPEKESEEGCPKRGFE--GSCSQKESEEG-NPVRGSEEDS---- 498
Query: 259 LLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQ 318
P ++ +K+ +++ ++N +E + D + S + + + DS+
Sbjct: 499 ----PKKESKKKTL------KNDCEENGLAKESEDDLNKESEEE---VGPTKESEEDDSE 545
Query: 319 EDSKENLSQEESQN-VDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVED 377
++S E+ S+++S++ + E+ E +L + + E E V+ + +N + + +D
Sbjct: 546 KESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDD 605
Query: 378 QEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHS 437
+ EE S E EE+ E F +ES E EDE + ++GL++
Sbjct: 606 GSEKVLDEEGSEREFDEDSDEKEEEEDTYEKV----FDDESDEK-EDEEYADEKGLEAAD 660
Query: 438 SSAE--SQSEESHSEEDDSDSQDSSRSK---------EDSNSTESKSSSEEDGQLKNIEI 486
AE E+ E DD + +D+ + ED +S E EED K +
Sbjct: 661 KKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDD 720
Query: 487 ESRKLTVDAYHNKPIG------------DQDDND 508
+ T+ + + G D DD+D
Sbjct: 721 SDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
Score = 66.6 bits (161), Expect = 5e-11
Identities = 81/367 (22%), Positives = 145/367 (39%), Gaps = 72/367 (19%)
Query: 12 GLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQ 71
G++ P+ + ++ED E+ E S +K SS E+ E+ +
Sbjct: 419 GMAFEEPIDEKKFEKTEDGGEF------------EEGASENNAKESSPEKEAEEGCPEKE 466
Query: 72 SEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGN 131
SEEG GF S + E + G+ G ++ P ++E
Sbjct: 467 SEEGCPKR----------GFEGSCSQ-------KESEEGNPVRGSEEDSP----KKESKK 505
Query: 132 SRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEE 191
L +D + + + SE+ + + T ES E D+ E ES+E
Sbjct: 506 KTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDS---------------EKESDE 550
Query: 192 HWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGEN-SEQAN 250
S+ +S G E ++ G++ D E G+ + + KE EN SE +
Sbjct: 551 DC----SEKQSEDGSEREFEENGLEKD-----LDEEGSEKELHENVLDKELEENDSENSE 601
Query: 251 TQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSR----DTGL 306
+D G ++L+ R +ED + ++ +T E+V D ++ + GL
Sbjct: 602 FEDDGSEKVLDEEG-----SEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGL 656
Query: 307 -SQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSE---SQEEVVSE 362
+ ++ +GD+ E E +E ++ DG E + E L ++S+E +EE SE
Sbjct: 657 EAADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADE-KLFEDDDSNEKLFDEEEDSSE 715
Query: 363 SRGDNPD 369
D+ D
Sbjct: 716 KLFDDSD 722
Score = 66.2 bits (160), Expect = 7e-11
Identities = 79/393 (20%), Positives = 149/393 (37%), Gaps = 46/393 (11%)
Query: 136 SDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVG 195
+D ++T + EE +G ++ + +R L D V + G S SE
Sbjct: 351 TDYQVEETSREREERL-RGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTS 409
Query: 196 GGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSG 255
+ E++ G E E I ++ + + S N+++++ +
Sbjct: 410 KMNAQETATGMAFE-----------EPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEA 458
Query: 256 GSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKG 315
E S + K + E ++ N + + DS + + + T + +
Sbjct: 459 EEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLA 518
Query: 316 DSQEDSKENLSQEESQNVDGPSSESSQE-ANLSSQENSSESQEEVVSESRGDNPDPTTSY 374
ED S+EE GP+ ES ++ + S E+ SE Q E SE +
Sbjct: 519 KESEDDLNKESEEEV----GPTKESEEDDSEKESDEDCSEKQSEDGSERE---------F 565
Query: 375 VEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 434
E+ + D EE S L + + E+ DSE+SE F ++ E DE S +E +
Sbjct: 566 EENGLEKDLDEEGSEKELHENVLDKELEENDSENSE---FEDDGSEKVLDEEGSEREFDE 622
Query: 435 SHSSSAESQSEESHSEEDDSDSQD------------SSRSKEDSNS-----TESKSSSEE 477
E + +D+SD ++ + + E+ ++ ES +E
Sbjct: 623 DSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDE 682
Query: 478 DGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQ 510
D K +E KL D N+ + D++++ +
Sbjct: 683 DADGKEVEDADEKLFEDDDSNEKLFDEEEDSSE 715
Score = 56.2 bits (134), Expect = 7e-08
Identities = 62/228 (27%), Positives = 93/228 (40%), Gaps = 21/228 (9%)
Query: 26 ESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIY 85
ESED + PT E +S + S E+ +ED S+ E GL D +
Sbjct: 520 ESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDE--- 576
Query: 86 RLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQ 145
G + + DK+ +E+DS + F DD S K E G+ R DEDSD+ +
Sbjct: 577 ---EGSEKELHENVLDKELEENDSENSEFEDDGS---EKVLDEEGSER-EFDEDSDEK-E 628
Query: 146 ASEESAPQGQDSAQDTTSESRELDNE--DRVDSKPEGGDST----QESESEEHWVGGGSD 199
E++ + D D + D + + D K E GD+ +ES+ +E G +
Sbjct: 629 EEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDEDADGKE 688
Query: 200 GESSHGDGSELDDEGMQSDDPESIRSER----GNSRMNSAGMKSKESG 243
E + E DD + D E SE+ + R G S E G
Sbjct: 689 VEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEEG 736
Score = 53.5 bits (127), Expect = 4e-07
Identities = 63/353 (17%), Positives = 130/353 (36%), Gaps = 24/353 (6%)
Query: 175 DSKPEGGDSTQESESEE----------HWVGGGSDGESSHGDGSELDDEGMQSDDPESIR 224
D P+G S + EE W GG + ++ E + E +R
Sbjct: 308 DRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSREREERLR 367
Query: 225 SERG--NSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSEL 282
N+ + G++ +S SE+A S EHPS S+++ ++ + +
Sbjct: 368 GWEAFLNAPEANRGLRRSDSVSASERAGP--SRARHFSEHPST-----SKMNAQETATGM 420
Query: 283 DDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQ 342
++E K + TE+ + G S+ + +++++E ++ES+
Sbjct: 421 AFEEPIDEKKFEKTEDGGEFEEGASE-NNAKESSPEKEAEEGCPEKESEEGCPKRGFEGS 479
Query: 343 EANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREE 402
+ S+E + E S + + E+ + SE+D + ++E
Sbjct: 480 CSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKES 539
Query: 403 QADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHS----EEDDSDSQD 458
+ D ES E E + GL+ S+ E + E +++DS++
Sbjct: 540 EEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSEN 599
Query: 459 SSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQD 511
S + S + SE + + E E + T + + +++D + D
Sbjct: 600 SEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYAD 652
Score = 36.2 bits (82), Expect = 0.073
Identities = 39/157 (24%), Positives = 62/157 (39%), Gaps = 10/157 (6%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEE-----GLG 77
+N+E ED K + + + + + E+ +D SD + EE GL
Sbjct: 598 ENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLE 657
Query: 78 SDDHQYIYRLAGG--FSRSTGKGGDDKDDDEDDSGDDT-FGDDDSGPGPKDRQEGGNSRL 134
+ D + A F S K +D D E + D+ F DDDS D +E + +L
Sbjct: 658 AADKKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKL 717
Query: 135 GSDEDSDDTIQ--ASEESAPQGQDSAQDTTSESRELD 169
D D T+ S E P S+ +S+ + D
Sbjct: 718 FDDSDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 75.5 bits (184), Expect = 1e-13
Identities = 80/383 (20%), Positives = 149/383 (38%), Gaps = 41/383 (10%)
Query: 134 LGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHW 193
+G ++DS E + + Q+ +E + L N D DSK DS +E E +H
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKR---DSLEEGELRDHC 57
Query: 194 VGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQD 253
+ + S + ++D G + DD +I+ + SR + E + + ++
Sbjct: 58 MEI-TIRNSPYRREDSMEDRG-EEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHS 115
Query: 254 SGGSQLLEHPSRKIFRKSRISEEDDRSELD-DNNTMEEVKSDSTENSNSRDTGLSQPRRD 312
+ G + R+ R+ R EE D++ + + E+ + + R L + R
Sbjct: 116 AEGGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRER 175
Query: 313 SKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSS-ESQEEVVSESR------- 364
+ ++ ++ +E + + E +S+ + E + V S
Sbjct: 176 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 235
Query: 365 --------GDNPDPTT----------SYVEDQEDSDSSEEDSSHTLSHSKSESREEQADS 406
GD P S ++D DS+ + + + S S S EE+ +
Sbjct: 236 PPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE 295
Query: 407 ESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS------ 460
E E + E E E+E +E S+S A QS E SEE+ S+ ++
Sbjct: 296 EEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLL 355
Query: 461 ---RSKEDSNSTESKSSSEEDGQ 480
S+ D +S ES+ + EE G+
Sbjct: 356 VVPESRFDRDSGESEEAEEEVGE 378
Score = 62.0 bits (149), Expect = 1e-09
Identities = 81/386 (20%), Positives = 141/386 (36%), Gaps = 44/386 (11%)
Query: 99 GDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSA 158
GD+KD + + D+ + +++ E RL + +D D + EE + +D
Sbjct: 2 GDEKDSWKVKTLDEILQEKKRRKEQEEKAE--IKRLKNSDDRDSKRDSLEEG--ELRDHC 57
Query: 159 QDTTSESRELDNEDRVDSKPEGGDST--------------------QESESEEHWVGGGS 198
+ T + ED ++ + E DS + E H
Sbjct: 58 MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAE 117
Query: 199 DGESSHGDGSELDDEGMQSDDPESIRSE-RGNSRMNSAGMKSKESGENSEQANTQDSGGS 257
G+ + E + ++ + R E R A S+ + EQ +
Sbjct: 118 GGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERER 177
Query: 258 QLLEHPSRKIFRKSRISEEDDRSELDD--------NNTMEEVKSDSTENSNSRDTGLSQP 309
++ E + +K R ++R + + + TM E SD + S+ + P
Sbjct: 178 KMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP 237
Query: 310 R-RDSKGDSQEDSKENLSQEESQNVD----GPSSESSQEANLSSQENSSESQEEVVSESR 364
R R GD ++ KE +E D S + A SS E+ S S+EE E
Sbjct: 238 RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE 297
Query: 365 GDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSE------SREEQADSESSESLNFSEES 418
+ T+ E++E+ + EE+ + + S SE S EE ++ E E+ N
Sbjct: 298 EEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVV 357
Query: 419 PESPEDENSSSQEGLQSHSSSAESQS 444
PES D +S E + QS
Sbjct: 358 PESRFDRDSGESEEAEEEVGEGTPQS 383
Score = 47.0 bits (110), Expect = 4e-05
Identities = 43/187 (22%), Positives = 78/187 (41%), Gaps = 41/187 (21%)
Query: 41 PTPPLESSESSEGSKVSSEEQANE-----DPSDSTQSEEGLGSDDHQYIYRLAGGFSRST 95
P PP E E +G K EE+ E D D + SE S A S +
Sbjct: 234 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSS---------AESSSAES 284
Query: 96 GKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQ 155
G G ++++++E++ +E G++ S+E+ ++ + EE+ +
Sbjct: 285 GSGSEEEEEEEEEE-----------------EEEGSTSEESEEEEEEEEEEEEETGSNSE 327
Query: 156 DSAQDTT--------SESRELDNEDRVDSKPEG--GDSTQESESEEHWVGGGSDGESSHG 205
++++ + SE E +NE+ + PE + ESE E VG G+ S+
Sbjct: 328 EASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALT 387
Query: 206 DGSELDD 212
+G + D
Sbjct: 388 EGDYVPD 394
Score = 40.4 bits (93), Expect = 0.004
Identities = 36/157 (22%), Positives = 61/157 (38%), Gaps = 28/157 (17%)
Query: 123 PKDRQEGGNSR-------------LGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELD 169
P++R E G+ R L +D D+ + + + +S + E E +
Sbjct: 237 PRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 296
Query: 170 NEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDD---------- 219
E+ S E + +E E EE G + E+S E+ +E M D+
Sbjct: 297 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV 356
Query: 220 -PESIRSERGNSRMNSAGMKSKESGENSEQANTQDSG 255
PES R +R + A +E GE + Q++ G
Sbjct: 357 VPES-RFDRDSGESEEA---EEEVGEGTPQSSALTEG 389
>gi|4504487 histidine rich calcium binding protein precursor [Homo
sapiens]
Length = 699
Score = 75.5 bits (184), Expect = 1e-13
Identities = 101/512 (19%), Positives = 175/512 (34%), Gaps = 90/512 (17%)
Query: 17 LPVTRYQNNESEDSEE--------------WKGHLAQAPTPPLESSESSEGSKVSSE--E 60
LP R +++ ED +E +GH + E E E + S+E
Sbjct: 152 LPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGH 211
Query: 61 QANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFG----- 115
QA+ ++ +E + H + G R G DD DDD+DD DD
Sbjct: 212 QAHRHRGHGSEEDEDVSDGHHHH-----GPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEY 266
Query: 116 --------------DDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASE--ESAPQGQDSAQ 159
D+D G R R ++D+DD ++E A + QD +
Sbjct: 267 RHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDDDDVSTEYGHQAHRHQDHRK 326
Query: 160 DTTS--------------ESRELDNEDRVDSKPEG----------GDSTQESESEEHWVG 195
+ D E+ D E G +E E EE V
Sbjct: 327 EEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQ 386
Query: 196 GGSDGESSHGDGSELDDEGMQSDDPESI-----------RSERGNSRMNSAGMKSKESGE 244
G S G + D+E Q + + E ++ + ++S +
Sbjct: 387 FGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQ 446
Query: 245 NSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDT 304
+ E + Q ++ HP K DRS L +++ EE + + S+ D
Sbjct: 447 DEETGHGQRGSIKEMSHHPPGHTVVK-------DRSHLRKDDSEEEKEKEEDPGSHEEDD 499
Query: 305 GLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESR 364
S+ D ++ +EE + E +E +E E + E +E
Sbjct: 500 ESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVG 559
Query: 365 GD-NPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPE 423
+PD + E++E+ + EED R E+A SSE + + P+ +
Sbjct: 560 APLSPDHSE---EEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDAQ 616
Query: 424 DENSSSQEGLQSHSSSAE--SQSEESHSEEDD 453
+ + L + S ++ E H +E++
Sbjct: 617 EYGNYQPGSLCGYCSFCNRCTECESCHCDEEN 648
Score = 68.9 bits (167), Expect = 1e-11
Identities = 116/563 (20%), Positives = 189/563 (33%), Gaps = 125/563 (22%)
Query: 28 EDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRL 87
E S E + HL P E+ + S + + + D S+E Y + L
Sbjct: 52 EASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKE--------YGHLL 103
Query: 88 AGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDS------GPGPKDRQEGGNSR-------- 133
G S+ D K DE SG++ F + G G +D ++ R
Sbjct: 104 PGHRSQ------DHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRS 157
Query: 134 -LGSDEDSDDTIQASEES-----APQGQDSAQDTTSESRELDNEDRVDSKPEG------- 180
DED D+ + + +G D D E E + E+ S G
Sbjct: 158 HSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHR 217
Query: 181 --GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMK 238
G E S+ H G S H + + DD+ DD + + E + G
Sbjct: 218 GHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHG 277
Query: 239 SKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELD------------DNN 286
+E + S+ + +D PS + R EEDD + D ++
Sbjct: 278 IEEDEDVSDGHHHRD---------PSHR----HRSHEEDDNDDDDVSTEYGHQAHRHQDH 324
Query: 287 TMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANL 346
EEV++ S E+ + Q RD + D ++ S E Q G E +E +
Sbjct: 325 RKEEVEAVSGEHHHHVPDHRHQGHRDEEED-EDVSTERWHQGPQHVHHGLVDEEEEEEEI 383
Query: 347 SSQ----------ENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEE----DSSHTL 392
+ Q +E+ E + + P V +ED + S E SH
Sbjct: 384 TVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQ 443
Query: 393 SHSKSESREEQADS----------------------ESSESLNFSEESPESPEDENSSSQ 430
SH E+ Q S + SE EE P S E+++ SS+
Sbjct: 444 SHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSE 503
Query: 431 EGLQS--HSS------------------SAESQSEESHSEEDDSDSQDSSRSKEDSNSTE 470
+G + H S E + E+ EE++ D + E
Sbjct: 504 QGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLS 563
Query: 471 SKSSSEEDGQLKNIEIESRKLTV 493
S EE+ + + +E + + T+
Sbjct: 564 PDHSEEEEEEEEGLEEDEPRFTI 586
Score = 48.9 bits (115), Expect = 1e-05
Identities = 55/245 (22%), Positives = 91/245 (37%), Gaps = 45/245 (18%)
Query: 289 EEVKSDSTENSNSRDTGLSQPRRDSK----------GDSQEDSK---ENLSQEESQNVDG 335
+E K STEN + + + + D G +D K E +S EE G
Sbjct: 69 DENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHG 128
Query: 336 PSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHS 395
+ + E+S+E + + S + S+ ++ ED S E H L H
Sbjct: 129 GQARGHRGHGSEDTEDSAEHRHHLPSHR-------SHSHQDEDEDEVVSSEHHHHILRHG 181
Query: 396 KSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSD 455
E + E EE E E+E +S++ G Q+H H E+D D
Sbjct: 182 HRGHDGEDDEGE--------EEEEEEEEEEEASTEYGHQAHR-------HRGHGSEEDED 226
Query: 456 SQD-------SSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDND 508
D S R + + ++D ++ IE R A+ ++ G ++D D
Sbjct: 227 VSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRH---QAHRHQGHGIEEDED 283
Query: 509 CQDGY 513
DG+
Sbjct: 284 VSDGH 288
>gi|16445033 ACRC protein [Homo sapiens]
Length = 691
Score = 74.3 bits (181), Expect = 2e-13
Identities = 54/252 (21%), Positives = 113/252 (44%), Gaps = 27/252 (10%)
Query: 244 ENSEQANTQDSGGSQLLE-----------HPSRKIFRKSRISEEDDRSELDDNNTMEEVK 292
++ E+ +T + ++LLE H I + +DD DDN EV
Sbjct: 82 DSDEECHTHEEKKAKLLEINSDDESPECCHVKPAIQEPPIVISDDDND--DDNGNDLEVP 139
Query: 293 SDSTENSNSRDTGLSQPRRDSKGDSQ--EDSKENLSQEESQNVDGPSSESSQEANLSSQE 350
D++++S + D D+ DS+ +D+ ++ + + D + + + + + +
Sbjct: 140 DDNSDDSEAPD--------DNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSDVPDD 191
Query: 351 NSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEE--DSSHTLSHSKSESREEQADSES 408
NS +S ++ +S DN D + + +DSD ++ D S S +S S+
Sbjct: 192 NSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDDSSDDSDVPDDSSDDSEAPDDSSDD 251
Query: 409 SESLNFSEESPESPED--ENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDS 466
SE+ + S + E+P+D ++S + + S +++ S++S + +D SD ++ K D
Sbjct: 252 SEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEASDDSSDDSEASDDSSDDSEAPDDKSDD 311
Query: 467 NSTESKSSSEED 478
+ S + D
Sbjct: 312 SDVPEDKSDDSD 323
Score = 70.5 bits (171), Expect = 4e-12
Identities = 60/262 (22%), Positives = 113/262 (43%), Gaps = 28/262 (10%)
Query: 219 DPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDD 278
+P + S+ N N ++ + + +A +S S+ + S DD
Sbjct: 118 EPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNS------------DD 165
Query: 279 RSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSS 338
DDN+ E D++++S+ D D+ DS +D+ ++ S + S + D P
Sbjct: 166 SEAPDDNSDDSEAPDDNSDDSDVPD--------DNSDDSSDDNSDDSSDDNSDDSDVPDD 217
Query: 339 ESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSE 398
+S S + S +V +S D+ P S + + DSS++ + S SE
Sbjct: 218 KSDD----SDVPDDSSDDSDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSE 273
Query: 399 SREEQADSE--SSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDS 456
+ ++ +D S +S + SE S +S +D S + + S E +S++S +D+SD
Sbjct: 274 APDDSSDDSEASDDSSDDSEASDDSSDD--SEAPDDKSDDSDVPEDKSDDSDVPDDNSDD 331
Query: 457 QDSSRSKEDSNSTESKSSSEED 478
+ ED + +S EE+
Sbjct: 332 LEVPVPAEDLCNEGQIASDEEE 353
Score = 68.9 bits (167), Expect = 1e-11
Identities = 79/378 (20%), Positives = 155/378 (41%), Gaps = 42/378 (11%)
Query: 28 EDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRL 87
+D+++ G+ + P + SE+ + + S + +A +D SD +++ + SDD +
Sbjct: 126 DDNDDDNGNDLEVPDDNSDDSEAPDDN--SDDSEAPDDNSDDSEAPDD-NSDDSEAPDDN 182
Query: 88 AGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQAS 147
+ D DD+ DDS DD D D P D+ + + S +DSD +S
Sbjct: 183 SDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDV---PDDKSDDSDVPDDSSDDSDVPDDSS 239
Query: 148 EES-APQGQDSAQDTTSESRELDN----EDRVDSKPEGGDSTQESESEEHWVGGGSDGES 202
++S AP DS+ D+ + D+ +D D DS+ +SE+ + +
Sbjct: 240 DDSEAP--DDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEASDDSSDDSEASDD 297
Query: 203 SHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQL-LE 261
S D DD+ SD PE + S+ ++ D L +
Sbjct: 298 SSDDSEAPDDKSDDSDVPE----------------------DKSDDSDVPDDNSDDLEVP 335
Query: 262 HPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTG--LSQPRRDSKGDSQE 319
P+ + + +I+ D EL + + DS++++ +D G LS+P D + + +
Sbjct: 336 VPAEDLCNEGQIA--SDEEELVEAAAAVS-QHDSSDDAGEQDLGENLSKPPSDPEANPEV 392
Query: 320 DSKENLSQEE-SQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQ 378
++ ++EE + V+ S+ + +++ + + E T + VE
Sbjct: 393 SERKLPTEEEPAPVVEQSGKRKSKTKTIVEPPRKRQTKTKNIVEPPRKRQTKTKNIVEPL 452
Query: 379 EDSDSSEEDSSHTLSHSK 396
+ ++ S T H K
Sbjct: 453 RKRKAKTKNVSVTPGHKK 470
Score = 68.2 bits (165), Expect = 2e-11
Identities = 74/332 (22%), Positives = 134/332 (40%), Gaps = 42/332 (12%)
Query: 100 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQ 159
DD +DD D+G+D DD+ + + + D++SDD+ +A ++++ + A
Sbjct: 125 DDDNDD--DNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSDDS-EAPDDNSDDSE--AP 179
Query: 160 DTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDD 219
D S+ ++ +++ DS + D + + S++ SD D S++ D+ SDD
Sbjct: 180 DDNSDDSDVPDDNSDDSSDDNSDDSSDDNSDD------SDVPDDKSDDSDVPDD--SSDD 231
Query: 220 PESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDR 279
+ +S E+ ++S + S E P DD
Sbjct: 232 SDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPD---------DSSDDS 282
Query: 280 SELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSE 339
DD++ E DS+++S + D D D +DS + V P+ +
Sbjct: 283 EASDDSSDDSEASDDSSDDSEAPDD--KSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAED 340
Query: 340 SSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSES 399
E ++S E E E + S+ D+ D D+ E+D LS S
Sbjct: 341 LCNEGQIASDE--EELVEAAAAVSQHDSSD------------DAGEQDLGENLSKPPS-- 384
Query: 400 REEQADSESSESLNFSEESPESPEDENSSSQE 431
+ +A+ E SE +EE P +P E S ++
Sbjct: 385 -DPEANPEVSERKLPTEEEP-APVVEQSGKRK 414
Score = 65.1 bits (157), Expect = 1e-10
Identities = 86/411 (20%), Positives = 159/411 (38%), Gaps = 40/411 (9%)
Query: 101 DKDDDED-------DSGDDTFGDDDSGPGPKDRQE---GGNSRLGSDEDSDDTIQASEES 150
+ ++DED S DDT G + PK + SR G S +A +
Sbjct: 13 EPEEDEDCYILNVQSSSDDTSGSSVARRAPKRQASCILNVQSRSGDTSGSSVARRAPKRQ 72
Query: 151 APQ----GQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGD 206
A DS ++ + + ++S E + + + SD ++ +
Sbjct: 73 ASSVVVIDSDSDEECHTHEEKKAKLLEINSDDESPECCHVKPAIQEPPIVISDDDNDDDN 132
Query: 207 GSELDDEGMQSDDPESIRSERGNSRM---NSAGMKSKESGENSEQANTQDSGGSQLLEHP 263
G++L+ SDD E+ +S NS ++ + + +A +S S + +
Sbjct: 133 GNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSDVPDDN 192
Query: 264 SRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKE 323
S S DD S DDN+ +V D +++S+ D S D DS +DS+
Sbjct: 193 SDD----SSDDNSDDSS--DDNSDDSDVPDDKSDDSDVPDD--SSDDSDVPDDSSDDSEA 244
Query: 324 NLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDS 383
+ SS+ S+ + SS ++ + SE+ D+ D + + +D D
Sbjct: 245 PDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEASDDSSDDSEAS-DDSSDDSE 303
Query: 384 SEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQ 443
+ +D S + +S + ++S+ L + + + +S E +++A SQ
Sbjct: 304 APDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAEDLCNEGQIASDEEELVEAAAAVSQ 363
Query: 444 SEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVD 494
H DD+ QD + SK S+ + N E+ RKL +
Sbjct: 364 ----HDSSDDAGEQDLGENL-------SKPPSDPEA---NPEVSERKLPTE 400
Score = 58.5 bits (140), Expect = 1e-08
Identities = 80/404 (19%), Positives = 155/404 (38%), Gaps = 46/404 (11%)
Query: 112 DTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSES------ 165
DT G + PK + +S + D DSD+ EE + + D S
Sbjct: 58 DTSGSSVARRAPKRQ---ASSVVVIDSDSDEECHTHEEKKAKLLEINSDDESPECCHVKP 114
Query: 166 ---------RELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQ 216
+ DN+D + E D + S+ + D SE D+
Sbjct: 115 AIQEPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSD 174
Query: 217 SDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEE 276
+ S+ + +++ S ++ ++S N+ DS + P K
Sbjct: 175 DSEAPDDNSDDSDVPDDNSDDSSDDNSDDSSDDNSDDS------DVPDDK---------S 219
Query: 277 DDRSELDDNNTMEEVKSDSTENSNSRDTGL--SQPRRDSKGDSQ--EDSKENLSQEESQN 332
DD DD++ +V DS+++S + D S+ DS DS+ +DS ++ + +
Sbjct: 220 DDSDVPDDSSDDSDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSS 279
Query: 333 VDGPSSESSQEANLSSQENS--SESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSH 390
D +S+ S + + +S ++S SE+ ++ +S S V D D +
Sbjct: 280 DDSEASDDSSDDSEASDDSSDDSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAE 339
Query: 391 TLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESH-- 448
L + + +E+ E++ +++ + S ++ E + E L S E+ E S
Sbjct: 340 DLCNEGQIASDEEELVEAAAAVSQHDSSDDAGEQDLG---ENLSKPPSDPEANPEVSERK 396
Query: 449 --SEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRK 490
+EE+ + + S ++ T + + + KNI RK
Sbjct: 397 LPTEEEPAPVVEQSGKRKSKTKTIVEPPRKRQTKTKNIVEPPRK 440
Score = 48.9 bits (115), Expect = 1e-05
Identities = 50/242 (20%), Positives = 99/242 (40%), Gaps = 25/242 (10%)
Query: 281 ELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSES 340
E D++ + V+S S + S S P+R + S+ + S P ++
Sbjct: 15 EEDEDCYILNVQSSSDDTSGS-SVARRAPKRQASCILNVQSRSGDTSGSSVARRAPKRQA 73
Query: 341 SQEANLSSQENSS----ESQEEVVSESRGDNPDPTTSYVED--QE-----DSDSSEEDSS 389
S + S + E ++ + E D+ P +V+ QE D +++D+
Sbjct: 74 SSVVVIDSDSDEECHTHEEKKAKLLEINSDDESPECCHVKPAIQEPPIVISDDDNDDDNG 133
Query: 390 HTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHS 449
+ L S + +A ++S+ E+P D+NS E +S +E+ + S
Sbjct: 134 NDLEVPDDNSDDSEAPDDNSDD----SEAP----DDNSDDSEAPDDNSDDSEAPDDNS-- 183
Query: 450 EEDDSD-SQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDND 508
DDSD D+S D NS +S + +D + + + + + D+ + + D +D
Sbjct: 184 --DDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDDSSDDSDVPDDSSDD 241
Query: 509 CQ 510
+
Sbjct: 242 SE 243
Score = 40.4 bits (93), Expect = 0.004
Identities = 33/140 (23%), Positives = 55/140 (39%), Gaps = 14/140 (10%)
Query: 380 DSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESP--------EDENSSSQE 431
DSDS EE HT K++ E +D ES E + E P +D+N + E
Sbjct: 80 DSDSDEE--CHTHEEKKAKLLEINSDDESPECCHVKPAIQEPPIVISDDDNDDDNGNDLE 137
Query: 432 GLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKL 491
+S +E+ + S DDS++ D + ++ S S D + ++
Sbjct: 138 VPDDNSDDSEAPDDNS----DDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSDVPDDNS 193
Query: 492 TVDAYHNKPIGDQDDNDCQD 511
+ N D++D D
Sbjct: 194 DDSSDDNSDDSSDDNSDDSD 213
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 74.3 bits (181), Expect = 2e-13
Identities = 80/385 (20%), Positives = 151/385 (39%), Gaps = 43/385 (11%)
Query: 134 LGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHW 193
+G ++DS E + + Q+ +E + L N D DSK DS +E E +H
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKR---DSLEEGELRDHR 57
Query: 194 VGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQ--ANT 251
+ + S + ++D G + DD +I+ + SR + E + + +++
Sbjct: 58 MEI-TIRNSPYRREDSMEDRG-EEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHS 115
Query: 252 QDSGGSQLLEHPSRKIFRKSRISEEDDRSELD-DNNTMEEVKSDSTENSNSRDTGLSQPR 310
+ G ++ R+ R+ R EE D++ + + E+ + + R L + R
Sbjct: 116 AEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKR 175
Query: 311 RDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSS-ESQEEVVSESR----- 364
+ ++ ++ +E + + E +S+ + E + V S
Sbjct: 176 ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 235
Query: 365 ----------GDNPDPTT----------SYVEDQEDSDSSEEDSSHTLSHSKSESREEQA 404
GD P S ++D DS+ + + + S S S EE+
Sbjct: 236 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE 295
Query: 405 DSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS---- 460
+ E E + E E E+E +E S+S A QS E SEE+ S+ ++
Sbjct: 296 EEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENH 355
Query: 461 -----RSKEDSNSTESKSSSEEDGQ 480
S+ D +S ES+ + EE G+
Sbjct: 356 LLVVPESRFDRDSGESEEAEEEVGE 380
Score = 64.7 bits (156), Expect = 2e-10
Identities = 81/360 (22%), Positives = 128/360 (35%), Gaps = 22/360 (6%)
Query: 97 KGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQD 156
K DD+D D + D ++ + + DD++ ++
Sbjct: 36 KNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKE 95
Query: 157 SAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQ 216
E R+ R S EGG + E E E E + + +
Sbjct: 96 KVHHRKDEKRKEKRRHRSHSA-EGGKHARVKEKEREHERRKRHREEQDKARREWERQKRR 154
Query: 217 SDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEE 276
E R ER R+ K + + EQ Q E R+ + R E
Sbjct: 155 EMAREHSRRER--DRLEQLERKRERERKMREQQKEQR-------EQKERERRAEERRKER 205
Query: 277 DDRSELDDNN-TMEEVKSDSTENSNSRDTGLSQPR-RDSKGDSQEDSKENLSQEESQNVD 334
+ R E+ ++ TM E SD + S+ + PR R GD ++ KE +E D
Sbjct: 206 EARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSD 265
Query: 335 ----GPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSH 390
S + A SS E+ S S+EE E + T+ E++E+ + EE+ +
Sbjct: 266 LQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 325
Query: 391 TLSHSKSE------SREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQS 444
+ S SE S EE ++ E E+ N PES D +S E + QS
Sbjct: 326 SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQS 385
Score = 53.5 bits (127), Expect = 4e-07
Identities = 45/179 (25%), Positives = 82/179 (45%), Gaps = 25/179 (13%)
Query: 41 PTPPLESSESSEGSKVSSEEQANE-----DPSDSTQSEEGLGSDDHQYIYRLAGGFSRST 95
P PP E E +G K EE+ E D D + SE S A S +
Sbjct: 236 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSS---------AESSSAES 286
Query: 96 GKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQ 155
G G ++++++E++ ++ ++S ++ +E +E ++ +ASE+SA +
Sbjct: 287 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE------EEEETGSNSEEASEQSA---E 337
Query: 156 DSAQDTTSESRELDNEDRVDSKPEG--GDSTQESESEEHWVGGGSDGESSHGDGSELDD 212
+ +++ SE E +NE+ + PE + ESE E VG G+ S+ +G + D
Sbjct: 338 EVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPD 396
Score = 30.4 bits (67), Expect = 4.0
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 8/95 (8%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQAN----EDPSDSTQSEEGLGS 78
+ E E+ EE +G ++ E E E S+ E+A+ E+ S+ SE+
Sbjct: 292 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 351
Query: 79 DDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDT 113
+++ + F R +G + ++ E++ G+ T
Sbjct: 352 NENHLLVVPESRFDRDSG----ESEEAEEEVGEGT 382
>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
Length = 1163
Score = 74.3 bits (181), Expect = 2e-13
Identities = 112/524 (21%), Positives = 183/524 (34%), Gaps = 75/524 (14%)
Query: 24 NNESEDSEEWKGHLAQA--PTPPLESSESSEGSKVSS----------------EEQANED 65
N+ +E K HL + P+ PL++S S + S V +
Sbjct: 282 NSMTELKPSSKAHLTKLKIPSQPLDASASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTE 341
Query: 66 PS-------DSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDD 118
PS +S QS G G + + G + KDD + S +D+ G+ D
Sbjct: 342 PSKFPFPTKESQQSNFGTGEQKRYNPSKTSNGHQSKSML----KDDLKLSSSEDSDGEQD 397
Query: 119 -------SGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNE 171
S PG NS G+D DD+ S + G DS +++S E NE
Sbjct: 398 CDKTMPRSTPGSNSEPSHHNSE-GADNSRDDSSSHSGSESSSGSDSESESSSSDSEA-NE 455
Query: 172 DRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSR 231
+ PE ++W+ + + S + + Q E GNS
Sbjct: 456 PSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTGNSY 515
Query: 232 MNSAGMKSKES---GENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTM 288
+++G K S G +S+ G + P++ R + + + +
Sbjct: 516 TDTSGPKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQPKKAEKAAA 575
Query: 289 EEVKSD-STENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLS 347
EE + E+ D S P K ++ K N+ +E + + + ++
Sbjct: 576 EEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESKSSPRPTAEKKKYKSTSK 635
Query: 348 SQENSSESQEEVVSESRGDNPD--PTTSYVEDQEDSD-------SSEEDSSHTLSHSKSE 398
S + S E E S S D + P +S +S+ S EE+ S S
Sbjct: 636 SSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSP 695
Query: 399 SREEQADSESSE-----------SLNFSEESPESP----EDENSSSQEGLQSHSSSAESQ 443
E++ S SE LN P P E + + H+ A+ Q
Sbjct: 696 MEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGEKKNVPEKHTREAQKQ 755
Query: 444 SEES--------HSEEDDSDSQDSSRSK-EDSNSTESKSSSEED 478
+ E H EDD+ + +S + K ED NS K SS +
Sbjct: 756 ASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHKPSSNRE 799
Score = 63.5 bits (153), Expect = 4e-10
Identities = 91/408 (22%), Positives = 147/408 (36%), Gaps = 65/408 (15%)
Query: 130 GNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESES 189
G + G D + + S +GQ ++ + S S KP+ S S S
Sbjct: 143 GTNSSGQRHDRESYNNSGSSSRKKGQHGSEHSKSRSSS-------PGKPQAVSSLNSSHS 195
Query: 190 EEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGN-----------SRMNSA--- 235
H G H D D P + G S+ NS
Sbjct: 196 RSH---GNDHHSKEHQRSKSPRDPDANWDSPSRVPFSSGQHSTQSFPPSLMSKSNSMLQK 252
Query: 236 ---------GMKSKESGENSEQANTQDSGGSQLLEHPSRKI-FRKSRI-SEEDDRSELDD 284
G +S E +SE ++Q G S PS K K +I S+ D S D
Sbjct: 253 PTAYVRPMDGQESMEPKLSSEHYSSQSHGNSMTELKPSSKAHLTKLKIPSQPLDASASGD 312
Query: 285 NNTMEEVKSDSTENSNSRDTGLSQPRRDSKGD----SQEDSKENLSQEE------SQNVD 334
+ ++E+ + T + T + P + ++E + N E S+ +
Sbjct: 313 VSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPTKESQQSNFGTGEQKRYNPSKTSN 372
Query: 335 GPSSES--SQEANLSSQENSSESQE---EVVSESRGDNPDPTTSYVEDQEDSDSSEEDS- 388
G S+S + LSS E+S Q+ + + G N +P+ + E +D+S +DS
Sbjct: 373 GHQSKSMLKDDLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSH---HNSEGADNSRDDSS 429
Query: 389 ----SHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ-------SHS 437
S + S S SES +DSE++E + PE P L S +
Sbjct: 430 SHSGSESSSGSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPA 489
Query: 438 SSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIE 485
SS +S S + + Q + S D++ + SS+ K I+
Sbjct: 490 SSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPKETSSATPGRDSKTIQ 537
Score = 50.1 bits (118), Expect = 5e-06
Identities = 107/497 (21%), Positives = 182/497 (36%), Gaps = 84/497 (16%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDP----SDSTQSEEGLGSD 79
+N +DS G + + + S SS+ + A+ +P ++ Q + L
Sbjct: 422 DNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKV 481
Query: 80 DHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGD---DTFGDDDSGPGPKDRQ--------E 128
+ + + S G K+ E +G+ DT G ++ R E
Sbjct: 482 NPHKVSPASSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPKETSSATPGRDSKTIQKGSE 541
Query: 129 GGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESR---ELDNEDRVDS--------- 176
G R S SD T Q Q + + + E R ++++E VD
Sbjct: 542 SGRGRQKSPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRH 601
Query: 177 ------------KPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIR 224
K E S + + ++ + + S + E D SD+ ES+
Sbjct: 602 KAATKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSR-EIIETDTSSSDSDESESLP 660
Query: 225 SERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDD 284
S +S + +DS Q + P + S +SE DDR L
Sbjct: 661 P----SSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLI- 715
Query: 285 NNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEA 344
VK D N +R G +P ++++ E K+N+ ++ ++ +SE
Sbjct: 716 ------VKIDL--NLLTRIPG--KPYKETEPPKGE--KKNVPEKHTREAQKQASEKVSNK 763
Query: 345 NLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQA 404
+N +++ SES+ P T ED +S+ H S +RE
Sbjct: 764 GKRKHKNEDDNR---ASESK----KPKT------EDKNSA--------GHKPSSNRESSK 802
Query: 405 DSESSES-LNFSEESP---ESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS 460
S + E L S P + P+ E+ S + + S SSS +S S S+ E S SS
Sbjct: 803 QSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTI-SQSSSLKSSSN-SNKETSGSSKNSSS 860
Query: 461 RSKEDSNSTESKSSSEE 477
SK+ ++ SSS+E
Sbjct: 861 TSKQKKTEGKTSSSSKE 877
Score = 49.3 bits (116), Expect = 8e-06
Identities = 82/413 (19%), Positives = 155/413 (37%), Gaps = 54/413 (13%)
Query: 132 SRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEE 191
S LG+ ++ D I + S P+ + T S + + + GG S
Sbjct: 54 SMLGNYDEMKDFI--GDRSIPKLVAIPKPTVPPSADEKSNPNFFEQRHGG-----SHQSS 106
Query: 192 HWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKS-----KESGENS 246
W G +S S+ G+QS S +S NS+G + SG +S
Sbjct: 107 KWTPVGPAPSTSQ---SQKRSSGLQSGHSSQRTSAGSSSGTNSSGQRHDRESYNNSGSSS 163
Query: 247 EQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGL 306
+ S S+ K S ++ RS +D+++ E +S S + ++
Sbjct: 164 RKKGQHGSEHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHHSKEHQRSKSPRDPDANWDSP 223
Query: 307 SQPRRDSKGDSQEDSKENLSQEESQNVDGPSS-------ESSQEANLSSQENSSESQEEV 359
S+ S S + +L + + + P++ + S E LSS+ SS+S
Sbjct: 224 SRVPFSSGQHSTQSFPPSLMSKSNSMLQKPTAYVRPMDGQESMEPKLSSEHYSSQSHGNS 283
Query: 360 VSESRGDNPDPTTSYVEDQEDSDSSE-------EDSSHTLSHS------------KSESR 400
++E + + T + D+S ++ ++HS K+E
Sbjct: 284 MTELKPSSKAHLTKLKIPSQPLDASASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPS 343
Query: 401 EEQADSESSESLNF--SEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEED------ 452
+ ++ S+ NF E+ +P ++ Q S SE+S E+D
Sbjct: 344 KFPFPTKESQQSNFGTGEQKRYNPSKTSNGHQSKSMLKDDLKLSSSEDSDGEQDCDKTMP 403
Query: 453 ----DSDSQDSSRSKEDSNSTESKSSSEEDGQLKN-IEIESRKLTVDAYHNKP 500
S+S+ S + E ++++ SSS + + + ES + D+ N+P
Sbjct: 404 RSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEP 456
Score = 44.7 bits (104), Expect = 2e-04
Identities = 65/297 (21%), Positives = 112/297 (37%), Gaps = 41/297 (13%)
Query: 226 ERGNSRMNSAGMKSKES-GENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDD 284
+R N S G +SK ++ + ++++DS G Q + + S SE D
Sbjct: 363 KRYNPSKTSNGHQSKSMLKDDLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSEGAD 422
Query: 285 NNTMEEVK---------SDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDG 335
N+ + SDS S+S D+ ++P + + + + + N
Sbjct: 423 NSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVN 482
Query: 336 P---SSESSQEANL-SSQENSSESQEEVVSESRGDNPDPT-TSYVEDQEDSDSSEEDSSH 390
P S SS ++N+ SSQ E +E+ S D P TS DS + ++ S
Sbjct: 483 PHKVSPASSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPKETSSATPGRDSKTIQKGSES 542
Query: 391 TLSHSKSESR------------------EEQADSESSESLNFSEESP-----ESPEDENS 427
KS ++ E+ A E L E+P P +
Sbjct: 543 GRGRQKSPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHK 602
Query: 428 SSQEGLQSHSSSAESQSEESHSEEDD---SDSQDSSRSKEDSNSTESKSSSEEDGQL 481
++ +G + + ES+S + E S S+ S +S+E + S S S+E L
Sbjct: 603 AATKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESL 659
Score = 43.1 bits (100), Expect = 6e-04
Identities = 45/189 (23%), Positives = 70/189 (37%), Gaps = 27/189 (14%)
Query: 311 RDSKGDSQEDSKENLSQEESQNVDG----------PSSESSQEANLSSQENSSESQEEVV 360
R+ + + +E +QE Q D P +S+E LSS+ S + +
Sbjct: 3 REDRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSKEDKLSSRIQSMLGNYDEM 62
Query: 361 SESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPE 420
+ GD P + S++E S+ EQ S +S ++ P
Sbjct: 63 KDFIGDRSIPKLVAIPKPTVPPSADEKSNPNFF--------EQRHGGSHQSSKWTPVGPA 114
Query: 421 SPEDENSSSQEGLQSH---------SSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTES 471
++ GLQS SSS + S + H E ++S SSR K S S
Sbjct: 115 PSTSQSQKRSSGLQSGHSSQRTSAGSSSGTNSSGQRHDRESYNNSGSSSRKKGQHGSEHS 174
Query: 472 KSSSEEDGQ 480
KS S G+
Sbjct: 175 KSRSSSPGK 183
Score = 32.7 bits (73), Expect = 0.81
Identities = 32/156 (20%), Positives = 67/156 (42%), Gaps = 6/156 (3%)
Query: 19 VTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSE---EQANEDPSDSTQSEEG 75
+TR +++E KG P ++ KVS++ + NED + +++S++
Sbjct: 723 LTRIPGKPYKETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKP 782
Query: 76 LGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLG 135
D + ++ + S +KD +G D + G + R +S L
Sbjct: 783 KTEDKNSAGHKPSSNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLK 842
Query: 136 SDEDSD-DTIQASEESAPQGQDSAQD--TTSESREL 168
S +S+ +T +S+ S+ + + T+S S+E+
Sbjct: 843 SSSNSNKETSGSSKNSSSTSKQKKTEGKTSSSSKEV 878
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 73.9 bits (180), Expect = 3e-13
Identities = 82/374 (21%), Positives = 141/374 (37%), Gaps = 33/374 (8%)
Query: 134 LGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHW 193
+G ++DS E + + Q+ +E + L N D DSK DS +E E +H
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKR---DSLEEGELRDHC 57
Query: 194 V-----GGGSDGESSHGDGSELDDE-----GMQSDDPESI---RSERGNSRMNSAGMKSK 240
+ E S D E DD Q E + + E+ + A +K +
Sbjct: 58 MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKER 117
Query: 241 ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSN 300
E QD + R++ R+ E D +L+ E + +
Sbjct: 118 EHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMRE--QQKE 175
Query: 301 SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQE--- 357
R+ + R + + +E +E + + D + + S E E
Sbjct: 176 QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGD 235
Query: 358 --EVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFS 415
+ V E + + D S ++D DS+ + + + S S S EE+ + E E +
Sbjct: 236 GRKPVKEEKMEERD-LLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGST 294
Query: 416 EESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS---------RSKEDS 466
E E E+E +E S+S A QS E SEE+ S+ ++ S+ D
Sbjct: 295 SEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDR 354
Query: 467 NSTESKSSSEEDGQ 480
+S ES+ + EE G+
Sbjct: 355 DSGESEEAEEEVGE 368
Score = 64.3 bits (155), Expect = 3e-10
Identities = 82/376 (21%), Positives = 140/376 (37%), Gaps = 34/376 (9%)
Query: 99 GDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSA 158
GD+KD + + D+ + +++ E RL + +D D + EE + +D
Sbjct: 2 GDEKDSWKVKTLDEILQEKKRRKEQEEKAE--IKRLKNSDDRDSKRDSLEEG--ELRDHC 57
Query: 159 QDTTSESRELDNEDRVDSKPEGGDST--------QESESEEHWVGGGSDGESSHGDGSEL 210
+ T + ED ++ + E DS E H + H E
Sbjct: 58 MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKER 117
Query: 211 DDEGMQSDDPESIRSERG---NSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKI 267
+ E + E ++ R R A S+ + EQ + ++ E +
Sbjct: 118 EHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQR 177
Query: 268 FRKSRISEEDDRSELDD--------NNTMEEVKSDSTENSNSRDTGLSQPR-RDSKGDSQ 318
+K R ++R + + + TM E SD + S+ + PR R GD +
Sbjct: 178 EQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGR 237
Query: 319 EDSKENLSQEESQNVD----GPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSY 374
+ KE +E D S + A SS E+ S S+EE E + T+
Sbjct: 238 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 297
Query: 375 VEDQEDSDSSEEDSSHTLSHSKSE------SREEQADSESSESLNFSEESPESPEDENSS 428
E++E+ + EE+ + + S SE S EE ++ E E+ N PES D +S
Sbjct: 298 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 357
Query: 429 SQEGLQSHSSSAESQS 444
E + QS
Sbjct: 358 ESEEAEEEVGEGTPQS 373
Score = 53.5 bits (127), Expect = 4e-07
Identities = 45/179 (25%), Positives = 82/179 (45%), Gaps = 25/179 (13%)
Query: 41 PTPPLESSESSEGSKVSSEEQANE-----DPSDSTQSEEGLGSDDHQYIYRLAGGFSRST 95
P PP E E +G K EE+ E D D + SE S A S +
Sbjct: 224 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSS---------AESSSAES 274
Query: 96 GKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQ 155
G G ++++++E++ ++ ++S ++ +E +E ++ +ASE+SA +
Sbjct: 275 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE------EEEETGSNSEEASEQSA---E 325
Query: 156 DSAQDTTSESRELDNEDRVDSKPEG--GDSTQESESEEHWVGGGSDGESSHGDGSELDD 212
+ +++ SE E +NE+ + PE + ESE E VG G+ S+ +G + D
Sbjct: 326 EVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPD 384
Score = 30.4 bits (67), Expect = 4.0
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 8/95 (8%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQAN----EDPSDSTQSEEGLGS 78
+ E E+ EE +G ++ E E E S+ E+A+ E+ S+ SE+
Sbjct: 280 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 339
Query: 79 DDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDT 113
+++ + F R +G + ++ E++ G+ T
Sbjct: 340 NENHLLVVPESRFDRDSG----ESEEAEEEVGEGT 370
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 73.2 bits (178), Expect = 5e-13
Identities = 119/568 (20%), Positives = 213/568 (37%), Gaps = 80/568 (14%)
Query: 13 LSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSE-EQANEDPSDSTQ 71
LSC + + + + E + + + +SS S+ S SS+ E A E+ S +
Sbjct: 172 LSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRK 231
Query: 72 SEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGN 131
+ S H+ + +S + + ++ + T ++ P P++R
Sbjct: 232 KKHRKNSRKHKKEKKKRKKSKKSASS--ESEAENLEAQPQSTVRPEEIPPIPENRFLMRK 289
Query: 132 SRLGSDEDSDDTIQASEE---SAPQGQDSAQD----TTSESRELDNED----RVDSKPEG 180
S +DE + E + P Q ++ T R++ R S+
Sbjct: 290 SPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRS 349
Query: 181 GDSTQESESEEHW---------VGGGSDGESSHGDGSELD------------------DE 213
D + SE+ HW + S GD SEL+ D
Sbjct: 350 RDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDH 409
Query: 214 GMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSR-KIFRKSR 272
S+ P + + + + K ++ NSE+ + + + + SR K KS+
Sbjct: 410 RNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSK 469
Query: 273 ISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDS--KENLSQEES 330
E D + ++ M +S ++ N ++ + + DSKG QE S KE Q ES
Sbjct: 470 SKERDSKHNRNEEKRMRS-RSKGRDHENVKE---KEKQSDSKGKDQERSRSKEKSKQLES 525
Query: 331 QNVDGPSSES----------SQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQED 380
++ + S+S S+E +++ ++S S+ S SR D S D++
Sbjct: 526 KSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSR-DRSRRVRSRTHDRDR 584
Query: 381 SDSSE-----EDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSS------ 429
S S E E S+S R S+ S E E S S
Sbjct: 585 SRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKY 644
Query: 430 --QEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSK----EDSNSTESKSSSEED----G 479
QE SH + +S+ D +S ++SR K + S ++ K SS+++
Sbjct: 645 RNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSS 704
Query: 480 QLKNIEIESRKLTVDAYHNKPIGDQDDN 507
LKN E E + +V+ + K G ++D+
Sbjct: 705 MLKNKEDEKIRSSVEKENQKSKGQENDH 732
Score = 60.5 bits (145), Expect = 4e-09
Identities = 73/361 (20%), Positives = 146/361 (40%), Gaps = 40/361 (11%)
Query: 118 DSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNED-RVDS 176
D K+R NS + +A +S + ++ ++ +S+ NE+ R+ S
Sbjct: 428 DHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRS 487
Query: 177 KPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAG 236
+ +G D E E+ G D E S E ++ S E+ + +
Sbjct: 488 RSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSR 547
Query: 237 MKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEED-DRSELDDNNTMEEVKSDS 295
G++S + T++ S+ SR++ +SR + D RS+ +E +
Sbjct: 548 ECDITKGKHSYNSRTRERSRSR---DRSRRV--RSRTHDRDRSRSKEYHRYREQEYRRRG 602
Query: 296 TENSNSRDTGLSQPRRDSKGDSQEDSKENLSQE-ESQNVDGPSSESSQEANLSSQENSSE 354
S R T + R + + DS+ + +E +S+N D +QE+ S ++ +SE
Sbjct: 603 RSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKD---KYRNQESKSSHRKENSE 659
Query: 355 SQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNF 414
S++ + S+SR N S + SRE++AD + S
Sbjct: 660 SEKRMYSKSRDHN---------------------------SSNNSREKKADRDQSPFSKI 692
Query: 415 SEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSN--STESK 472
+ S ++ + + + SS E ++++S +E+D + + + +S+ + E K
Sbjct: 693 KQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDK 752
Query: 473 S 473
S
Sbjct: 753 S 753
Score = 48.9 bits (115), Expect = 1e-05
Identities = 75/381 (19%), Positives = 130/381 (34%), Gaps = 49/381 (12%)
Query: 19 VTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGS 78
V+ N ++E ++ K H + + + + + + ++ + S S E+
Sbjct: 412 VSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSK 471
Query: 79 DDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSR----- 133
+ R RS KG D ++ E + D+ G D K++ + S+
Sbjct: 472 ERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHD 531
Query: 134 --LGSDEDSDDTIQASEESAPQGQDSAQDTTSE-SRELDNEDRVDSKPEGGDSTQESESE 190
++D ++ E +G+ S T E SR D RV S+ D ++ E
Sbjct: 532 HSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYH 591
Query: 191 EHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQAN 250
+ E RG SR S +
Sbjct: 592 RY---------------------------REQEYRRRGRSRSRERRTPPGRSRSKDRRRR 624
Query: 251 TQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPR 310
+DS S+ E SR K + ++ +S ++ E +S+ S SRD S
Sbjct: 625 RRDSRSSEREESQSR---NKDKYRNQESKS----SHRKENSESEKRMYSKSRDHNSSNNS 677
Query: 311 RDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDP 370
R+ K D + + Q N +SS N E S E+ +S+G D
Sbjct: 678 REKKADRDQSPFSKIKQSSQDN----ELKSSMLKN-KEDEKIRSSVEKENQKSKGQENDH 732
Query: 371 TTSYVE--DQEDSDSSEEDSS 389
+ D E S ++ED S
Sbjct: 733 VHEKNKKFDHESSPGTDEDKS 753
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 72.8 bits (177), Expect = 7e-13
Identities = 80/383 (20%), Positives = 147/383 (38%), Gaps = 50/383 (13%)
Query: 134 LGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHW 193
+G ++DS E + + Q+ +E + L N D DSK DS +E E +H
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKR---DSLEEGELRDHC 57
Query: 194 VGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQD 253
+ + S + ++D G + DD +I+ + SR + E + + A ++
Sbjct: 58 MEI-TIRNSPYRREDSMEDRG-EEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKE 115
Query: 254 SGGSQLLEHPSRKIFRKSRISEEDDRSELD-DNNTMEEVKSDSTENSNSRDTGLSQPRRD 312
R+ R+ R EE D++ + + E+ + + R L + R
Sbjct: 116 K---------EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRER 166
Query: 313 SKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSS-ESQEEVVSESR------- 364
+ ++ ++ +E + + E +S+ + E + V S
Sbjct: 167 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 226
Query: 365 --------GDNPDPTT----------SYVEDQEDSDSSEEDSSHTLSHSKSESREEQADS 406
GD P S ++D DS+ + + + S S S EE+ +
Sbjct: 227 PPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE 286
Query: 407 ESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS------ 460
E E + E E E+E +E S+S A QS E SEE+ S+ ++
Sbjct: 287 EEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLL 346
Query: 461 ---RSKEDSNSTESKSSSEEDGQ 480
S+ D +S ES+ + EE G+
Sbjct: 347 VVPESRFDRDSGESEEAEEEVGE 369
Score = 64.3 bits (155), Expect = 3e-10
Identities = 81/377 (21%), Positives = 143/377 (37%), Gaps = 35/377 (9%)
Query: 99 GDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSA 158
GD+KD + + D+ + +++ E RL + +D D + EE + +D
Sbjct: 2 GDEKDSWKVKTLDEILQEKKRRKEQEEKAE--IKRLKNSDDRDSKRDSLEEG--ELRDHC 57
Query: 159 QDTTSESRELDNEDRVDSKPEGGDSTQ----ESESEEHWVGGGSDGESSHGDGSELDDEG 214
+ T + ED ++ + E DS + S + V D + + + ++
Sbjct: 58 MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKE 117
Query: 215 MQSDDPESIRSERGNSRMNSAGMKSKESGENS---------------EQANTQDSGGSQL 259
+ + + R E+ +R K +E E+ +
Sbjct: 118 REHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQ 177
Query: 260 LEHPSRKIFRKSRISEEDDRSELDDNN-TMEEVKSDSTENSNSRDTGLSQPR-RDSKGDS 317
E R+ + R E + R E+ ++ TM E SD + S+ + PR R GD
Sbjct: 178 REQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDG 237
Query: 318 QEDSKENLSQEESQNVD----GPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTS 373
++ KE +E D S + A SS E+ S S+EE E + T+
Sbjct: 238 RKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE 297
Query: 374 YVEDQEDSDSSEEDSSHTLSHSKSE------SREEQADSESSESLNFSEESPESPEDENS 427
E++E+ + EE+ + + S SE S EE ++ E E+ N PES D +S
Sbjct: 298 ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDS 357
Query: 428 SSQEGLQSHSSSAESQS 444
E + QS
Sbjct: 358 GESEEAEEEVGEGTPQS 374
Score = 53.5 bits (127), Expect = 4e-07
Identities = 45/179 (25%), Positives = 82/179 (45%), Gaps = 25/179 (13%)
Query: 41 PTPPLESSESSEGSKVSSEEQANE-----DPSDSTQSEEGLGSDDHQYIYRLAGGFSRST 95
P PP E E +G K EE+ E D D + SE S A S +
Sbjct: 225 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSS---------AESSSAES 275
Query: 96 GKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQ 155
G G ++++++E++ ++ ++S ++ +E +E ++ +ASE+SA +
Sbjct: 276 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE------EEEETGSNSEEASEQSA---E 326
Query: 156 DSAQDTTSESRELDNEDRVDSKPEG--GDSTQESESEEHWVGGGSDGESSHGDGSELDD 212
+ +++ SE E +NE+ + PE + ESE E VG G+ S+ +G + D
Sbjct: 327 EVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPD 385
Score = 30.4 bits (67), Expect = 4.0
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 8/95 (8%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQAN----EDPSDSTQSEEGLGS 78
+ E E+ EE +G ++ E E E S+ E+A+ E+ S+ SE+
Sbjct: 281 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 340
Query: 79 DDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDT 113
+++ + F R +G + ++ E++ G+ T
Sbjct: 341 NENHLLVVPESRFDRDSG----ESEEAEEEVGEGT 371
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 71.2 bits (173), Expect = 2e-12
Identities = 85/390 (21%), Positives = 149/390 (38%), Gaps = 42/390 (10%)
Query: 124 KDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESREL------DNEDRVDSK 177
++R+ + R + S + +EES+ + Q T+S+ + + N R +K
Sbjct: 1097 RERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTK 1156
Query: 178 PEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGM 237
+ D T S S+ D ++S G+GS D + I+ N ++S
Sbjct: 1157 RKQADITSSSSSDIE-----DDDQNSIGEGSS---------DEQKIKPVTENLVLSSHTG 1202
Query: 238 KSKESGENSEQAN---TQDSGGSQLLEHPSRKIFRK-------SRISEEDDRSELDDNNT 287
+ SG+ + + T D P +I +K + +S ++D S D+
Sbjct: 1203 FCQSSGDEALSKSVPVTVDDDDDD--NDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1260
Query: 288 MEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSK----ENLSQEESQNVDGPSSESSQE 343
++ E + + +Q +S DS+E K L + + DG S E +
Sbjct: 1261 GKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKT 1320
Query: 344 ANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQ 403
+E ++ +V SE D+ + E E S+S +E T S K+E E Q
Sbjct: 1321 KPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSE--EVSESEDEQRPRTRSAKKAELEENQ 1378
Query: 404 ADSESSES---LNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS 460
+ + + E+S + + +E + E + EE E DDS S
Sbjct: 1379 RSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKG 1438
Query: 461 RSKEDSNSTESKSSSEEDGQLKNIEIESRK 490
R K + K +E LK E E RK
Sbjct: 1439 RKKIRKILKDDKLRTETQNALKE-EEERRK 1467
Score = 70.5 bits (171), Expect = 4e-12
Identities = 94/432 (21%), Positives = 169/432 (39%), Gaps = 54/432 (12%)
Query: 93 RSTGKGGDDKDDDEDDSGDDTFGDDDS-----GPGPKDRQEGGNS---RLGSDED----S 140
+STGKG ++ S + +G + G + RQ+ +S + ED S
Sbjct: 1028 KSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSS 1087
Query: 141 DDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDG 200
D ++ E + S ++T + D +S + Q + S++ V
Sbjct: 1088 DKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKK 1147
Query: 201 ESSHGDGSELDDEGMQSDDPESIRSERGNS--RMNSAGMKSKESGEN---SEQANTQDSG 255
+S ++ + S I + NS +S K K EN S S
Sbjct: 1148 RNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSS 1207
Query: 256 GSQLLEHPSRKIFRKSRISEEDDRSELDDNNT------MEEVKSD--STENSNSRDTGLS 307
G + L + ++ +DD + D N +EE+K++ S E+ +S D
Sbjct: 1208 GDEALS-------KSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1260
Query: 308 QPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQ----------EANLSSQENSSESQE 357
+R K + + E + + D S ES + + +S E+ E +
Sbjct: 1261 GKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKT 1320
Query: 358 EVVS--ESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFS 415
+ E +G N +S ED EDSD E S +S S+ E R ++ +E
Sbjct: 1321 KPKEHKEVKGRNRRKVSS--EDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAE----L 1374
Query: 416 EESPESPEDENSSSQEGLQSHSSS---AESQSEESHSEEDDSDSQDSSRSKEDSNSTESK 472
EE+ S + + + +Q SSS + S+ EE EE++ + ++ +ED N +SK
Sbjct: 1375 EENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDEND-DSK 1433
Query: 473 SSSEEDGQLKNI 484
S + +++ I
Sbjct: 1434 SPGKGRKKIRKI 1445
Score = 64.3 bits (155), Expect = 3e-10
Identities = 78/368 (21%), Positives = 140/368 (38%), Gaps = 44/368 (11%)
Query: 50 SSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDE--D 107
S++ + ++ D D Q+ G GS D Q I + S+ G DE
Sbjct: 1154 STKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALS 1213
Query: 108 DSGDDTFGDDDSGPGPKDR------QEGGNSRLGSDED---SDDTIQASEESAPQGQDSA 158
S T DDD P++R E + L SDED D+ + + + Q +++
Sbjct: 1214 KSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENP 1273
Query: 159 QDTTSESR---ELDNEDRVDSKP-------------EGGDSTQESES--EEHWVGGGSDG 200
D ++++ E D++ KP G+S +E ++ +EH G +
Sbjct: 1274 GDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNR 1333
Query: 201 ESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLL 260
+ SE D + +S E + R + K E EN +++ Q ++
Sbjct: 1334 RKVSSEDSE-DSDFQESGVSEEVSESEDEQRPRTRSAKKAELEEN-QRSYKQKKKRRRIK 1391
Query: 261 EHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQP--RRDSKGDSQ 318
KS EE++ E ++ EE + + EN +S+ G + R+ K D
Sbjct: 1392 VQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKL 1451
Query: 319 EDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVS-ESRGDNPDPTTSYVED 377
+N +EE + + ++ +E E EV+ E P T+ +
Sbjct: 1452 RTETQNALKEEEE----------RRKRIAEREREREKLREVIEIEDASPTKCPITTKLVL 1501
Query: 378 QEDSDSSE 385
ED ++ E
Sbjct: 1502 DEDEETKE 1509
Score = 62.4 bits (150), Expect = 1e-09
Identities = 86/378 (22%), Positives = 156/378 (41%), Gaps = 44/378 (11%)
Query: 138 EDSDDTIQASEESAPQG-QDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGG 196
+ SD+T + ++ + +G ++ + + + + + E + +S +G + E E H+ G
Sbjct: 934 DQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKG 993
Query: 197 GSDGESSHGDGSE----LDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQ 252
++ DG + + D+ + D S +E+ + +S +S E+ + N
Sbjct: 994 IKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSC-----DSSEDKKSKN-- 1046
Query: 253 DSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRD 312
G+ E K+ KS +D S + +M+E + NS D L R +
Sbjct: 1047 ---GAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKE------DGCNSSDKRLK--RIE 1095
Query: 313 SKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTT 372
+ SK N + +S + + ESS++ Q SS+ + +V E + ++ T
Sbjct: 1096 LRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSL--RT 1153
Query: 373 SYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENS--SSQ 430
S Q D SS S + + D ++S S+E P EN SS
Sbjct: 1154 STKRKQADITSSS-------------SSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSH 1200
Query: 431 EGL-QSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKS--SSEEDGQLKNIEIE 487
G QS A S+S ++DD D+ +R + E K+ SS+EDG + E
Sbjct: 1201 TGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1260
Query: 488 SRKLTVDAYHNKPIGDQD 505
+K T P GD++
Sbjct: 1261 GKKRTGKQNEENP-GDEE 1277
Score = 58.9 bits (141), Expect = 1e-08
Identities = 99/492 (20%), Positives = 191/492 (38%), Gaps = 44/492 (8%)
Query: 18 PVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLG 77
PVT + E ++ + K L+ P + + + + N+ P S QSE
Sbjct: 634 PVTSNSDEECNETVKEKQKLS---VPVRKKDKRNSSDSAIDNPKPNKLPK-SKQSETVDQ 689
Query: 78 SDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGD--DDSGPGPKDRQEGGNSRLG 135
+ D + + SR + D D +E + T D +G K +++ +S G
Sbjct: 690 NSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSG 749
Query: 136 SDEDSDDTIQASEESAPQGQDSAQDTTSE-SRELDNEDRVDSKPEGGDSTQE-------- 186
SD D+ A + + Q +S EL+ E + SK +T++
Sbjct: 750 SDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDF 809
Query: 187 --SESEEHWVGG----GSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK 240
SE E+H G G + +GS D E Q + E+ S G ++ M+ +
Sbjct: 810 DSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQ--ERETFSSAEGTVDKDTTIMELR 867
Query: 241 ESGENSEQANTQDSGGSQLL-EHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENS 299
+ +QA+ G +L + S +++E ++S+ T ++V+ +
Sbjct: 868 DRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLS--- 924
Query: 300 NSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEV 359
D ++D ++ ED K+ S++ ++ PS + + Q SS E
Sbjct: 925 ---DIAEKFLKKDQSDETSEDDKKQ-SKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEK 980
Query: 360 VSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQAD-SESSESLNFSEES 418
+ E P ++ ++ + E S + S+ ++E +D +E S S +S
Sbjct: 981 LPEREEICHFPKG--IKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDS 1038
Query: 419 PESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEED 478
E + +N + G + +S + SD++ S ++ NS+ D
Sbjct: 1039 SEDKKSKNGAY--GREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSS--------D 1088
Query: 479 GQLKNIEIESRK 490
+LK IE+ R+
Sbjct: 1089 KRLKRIELRERR 1100
Score = 45.1 bits (105), Expect = 2e-04
Identities = 72/336 (21%), Positives = 118/336 (35%), Gaps = 40/336 (11%)
Query: 160 DTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDD 219
D+ + + E++ +K GG+ + EE + E ++D + S
Sbjct: 432 DSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDL-----DMDIVSVPSSV 486
Query: 220 PESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDR 279
PE I + + + + G SG Q +E S K+ IS +D+R
Sbjct: 487 PEDIFENLETAMEVQSSVDHQGDGS---------SGTEQEVESSSVKL----NISSKDNR 533
Query: 280 SELDDNNTMEEVKS-------DSTENSNSRDTGLSQPRRD-----SKGDSQEDSKENLSQ 327
+ T + K S NS + + +D S G + + K L Q
Sbjct: 534 GGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQ 593
Query: 328 EESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEED 387
E S N +E S S S + + NP + S E E ++
Sbjct: 594 ENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKL 653
Query: 388 SSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGL--------QSHSSS 439
S K S + D+ L S++S D+NS S E L SHSSS
Sbjct: 654 SVPVRKKDKRNSSDSAIDNPKPNKLPKSKQS--ETVDQNSDSDEMLAILKEVSRMSHSSS 711
Query: 440 AESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSS 475
+++ E H+ + K+D + KSS+
Sbjct: 712 SDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSST 747
Score = 40.0 bits (92), Expect = 0.005
Identities = 85/444 (19%), Positives = 159/444 (35%), Gaps = 46/444 (10%)
Query: 45 LESSESSEGSKVSSEEQANEDPS-----DSTQSEEGLGSDD------HQYIYRLAGGFSR 93
++SS +G S EQ E S S + G+ S Y+ S
Sbjct: 500 VQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSN 559
Query: 94 STGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQ 153
S KG D ++ +D G + G PK + G LG + ++ + +E S
Sbjct: 560 SPIKGADCQEVPQDKDGYKS-----CGLNPKLEKCG----LGQENSDNEHLVENEVSL-- 608
Query: 154 GQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDE 213
E +L RV + P +E + V SD E + E E
Sbjct: 609 --------LLEESDLRRSPRVKTTP------LRRPTETNPVTSNSDEECN-----ETVKE 649
Query: 214 GMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRI 273
+ P + +R +S K + ++ + + S + +++ R S
Sbjct: 650 KQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHS 709
Query: 274 SEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNV 333
S D +++++ +T + D + D G + R+ S S D+K+ S + S
Sbjct: 710 SSSD--TDINEIHTNHKTLYDLKTQAGKDDKG-KRKRKSSTSGSDFDTKKGKSAKSSIIS 766
Query: 334 DGPSSESSQEANLSSQ-ENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTL 392
S+ +N S+ E +S ++ + P T + ED S++ +
Sbjct: 767 KKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQG 826
Query: 393 SHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEED 452
+ S+E +D + + S E D++++ E L+ + S + +
Sbjct: 827 HKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIME-LRDRLPKKQQASASTDGVDK 885
Query: 453 DSDSQDSSRSKEDSNSTESKSSSE 476
S + S S E E+K S+
Sbjct: 886 LSGKEQSFTSLEVRKVAETKEKSK 909
Score = 38.1 bits (87), Expect = 0.019
Identities = 67/321 (20%), Positives = 119/321 (37%), Gaps = 34/321 (10%)
Query: 221 ESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRS 280
+S +S + + K S N E+ DS + S I K I +
Sbjct: 263 DSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKLI 322
Query: 281 ELDDNNTMEEVK--SDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQN-----V 333
E N VK +T+NS + + K + K +L+ EE N +
Sbjct: 323 ETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAM 382
Query: 334 DGPSSESSQE------------ANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDS 381
D + E + + A + + E ++ SE++ + ++ +
Sbjct: 383 DAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPT 442
Query: 382 DSSEEDSSHTLSHSKSESREE--QADSESSESLNFSEESPES--PED--ENSSSQEGLQS 435
+ + S H KS+ +EE + +SE L+ S S PED EN + +QS
Sbjct: 443 EEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQS 502
Query: 436 HSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDA 495
S + E + S + + SK++ +SK++++ +L KLT +
Sbjct: 503 SVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKEL------YVKLTPVS 556
Query: 496 YHNKPIGDQDDNDC---QDGY 513
N PI D + +DGY
Sbjct: 557 LSNSPIKGADCQEVPQDKDGY 577
Score = 36.2 bits (82), Expect = 0.073
Identities = 31/147 (21%), Positives = 52/147 (35%), Gaps = 7/147 (4%)
Query: 299 SNSRDTGLSQPRRDSKGDSQEDSKENLS------QEESQNVDGPSSESSQEANLSSQENS 352
S S+ L Q D S E+S+E S + + + G S S N + S
Sbjct: 7 SESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTS 66
Query: 353 SESQEEVVSESRGDN-PDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSES 411
S + + SR P T YVE ++ +E + S+ SE+ +
Sbjct: 67 SSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKEDG 126
Query: 412 LNFSEESPESPEDENSSSQEGLQSHSS 438
L+ + N ++ + H S
Sbjct: 127 LHGIVSCTACGQQVNHFQKDSIYRHPS 153
Score = 35.0 bits (79), Expect = 0.16
Identities = 28/107 (26%), Positives = 47/107 (43%), Gaps = 14/107 (13%)
Query: 212 DEGMQSDDPESIRSERGNSRMNSAGMKS------KESGENSEQANTQDSGGSQLLEHPSR 265
+E ++ P + + +++ +G S KE G +S + ++ SG S+ PS
Sbjct: 27 EESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSE-KSKSSGSSRSKRKPSI 85
Query: 266 KIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRD 312
++ E DD LDD E+ S ENS + T S P+ D
Sbjct: 86 V----TKYVESDDEKPLDDETVNEDA---SNENSENDITMQSLPKED 125
Score = 32.3 bits (72), Expect = 1.1
Identities = 23/101 (22%), Positives = 42/101 (41%), Gaps = 2/101 (1%)
Query: 381 SDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSA 440
S+ SEE SS + + +S+ + S+E S +++ SS S
Sbjct: 26 SEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPSI 85
Query: 441 ESQSEESHSEE--DDSDSQDSSRSKEDSNSTESKSSSEEDG 479
++ ES E+ DD + + ++ N +S +EDG
Sbjct: 86 VTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKEDG 126
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 71.2 bits (173), Expect = 2e-12
Identities = 85/390 (21%), Positives = 149/390 (38%), Gaps = 42/390 (10%)
Query: 124 KDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESREL------DNEDRVDSK 177
++R+ + R + S + +EES+ + Q T+S+ + + N R +K
Sbjct: 1135 RERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTK 1194
Query: 178 PEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGM 237
+ D T S S+ D ++S G+GS D + I+ N ++S
Sbjct: 1195 RKQADITSSSSSDIE-----DDDQNSIGEGSS---------DEQKIKPVTENLVLSSHTG 1240
Query: 238 KSKESGENSEQAN---TQDSGGSQLLEHPSRKIFRK-------SRISEEDDRSELDDNNT 287
+ SG+ + + T D P +I +K + +S ++D S D+
Sbjct: 1241 FCQSSGDEALSKSVPVTVDDDDDD--NDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1298
Query: 288 MEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSK----ENLSQEESQNVDGPSSESSQE 343
++ E + + +Q +S DS+E K L + + DG S E +
Sbjct: 1299 GKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKT 1358
Query: 344 ANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQ 403
+E ++ +V SE D+ + E E S+S +E T S K+E E Q
Sbjct: 1359 KPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSE--EVSESEDEQRPRTRSAKKAELEENQ 1416
Query: 404 ADSESSES---LNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS 460
+ + + E+S + + +E + E + EE E DDS S
Sbjct: 1417 RSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKG 1476
Query: 461 RSKEDSNSTESKSSSEEDGQLKNIEIESRK 490
R K + K +E LK E E RK
Sbjct: 1477 RKKIRKILKDDKLRTETQNALKE-EEERRK 1505
Score = 70.5 bits (171), Expect = 4e-12
Identities = 94/432 (21%), Positives = 169/432 (39%), Gaps = 54/432 (12%)
Query: 93 RSTGKGGDDKDDDEDDSGDDTFGDDDS-----GPGPKDRQEGGNS---RLGSDED----S 140
+STGKG ++ S + +G + G + RQ+ +S + ED S
Sbjct: 1066 KSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSS 1125
Query: 141 DDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDG 200
D ++ E + S ++T + D +S + Q + S++ V
Sbjct: 1126 DKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKK 1185
Query: 201 ESSHGDGSELDDEGMQSDDPESIRSERGNS--RMNSAGMKSKESGEN---SEQANTQDSG 255
+S ++ + S I + NS +S K K EN S S
Sbjct: 1186 RNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSS 1245
Query: 256 GSQLLEHPSRKIFRKSRISEEDDRSELDDNNT------MEEVKSD--STENSNSRDTGLS 307
G + L + ++ +DD + D N +EE+K++ S E+ +S D
Sbjct: 1246 GDEALS-------KSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1298
Query: 308 QPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQ----------EANLSSQENSSESQE 357
+R K + + E + + D S ES + + +S E+ E +
Sbjct: 1299 GKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKT 1358
Query: 358 EVVS--ESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFS 415
+ E +G N +S ED EDSD E S +S S+ E R ++ +E
Sbjct: 1359 KPKEHKEVKGRNRRKVSS--EDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAE----L 1412
Query: 416 EESPESPEDENSSSQEGLQSHSSS---AESQSEESHSEEDDSDSQDSSRSKEDSNSTESK 472
EE+ S + + + +Q SSS + S+ EE EE++ + ++ +ED N +SK
Sbjct: 1413 EENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDEND-DSK 1471
Query: 473 SSSEEDGQLKNI 484
S + +++ I
Sbjct: 1472 SPGKGRKKIRKI 1483
Score = 64.3 bits (155), Expect = 3e-10
Identities = 78/368 (21%), Positives = 140/368 (38%), Gaps = 44/368 (11%)
Query: 50 SSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDE--D 107
S++ + ++ D D Q+ G GS D Q I + S+ G DE
Sbjct: 1192 STKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALS 1251
Query: 108 DSGDDTFGDDDSGPGPKDR------QEGGNSRLGSDED---SDDTIQASEESAPQGQDSA 158
S T DDD P++R E + L SDED D+ + + + Q +++
Sbjct: 1252 KSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENP 1311
Query: 159 QDTTSESR---ELDNEDRVDSKP-------------EGGDSTQESES--EEHWVGGGSDG 200
D ++++ E D++ KP G+S +E ++ +EH G +
Sbjct: 1312 GDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNR 1371
Query: 201 ESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLL 260
+ SE D + +S E + R + K E EN +++ Q ++
Sbjct: 1372 RKVSSEDSE-DSDFQESGVSEEVSESEDEQRPRTRSAKKAELEEN-QRSYKQKKKRRRIK 1429
Query: 261 EHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQP--RRDSKGDSQ 318
KS EE++ E ++ EE + + EN +S+ G + R+ K D
Sbjct: 1430 VQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKL 1489
Query: 319 EDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVS-ESRGDNPDPTTSYVED 377
+N +EE + + ++ +E E EV+ E P T+ +
Sbjct: 1490 RTETQNALKEEEE----------RRKRIAEREREREKLREVIEIEDASPTKCPITTKLVL 1539
Query: 378 QEDSDSSE 385
ED ++ E
Sbjct: 1540 DEDEETKE 1547
Score = 62.4 bits (150), Expect = 1e-09
Identities = 86/378 (22%), Positives = 156/378 (41%), Gaps = 44/378 (11%)
Query: 138 EDSDDTIQASEESAPQG-QDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGG 196
+ SD+T + ++ + +G ++ + + + + + E + +S +G + E E H+ G
Sbjct: 972 DQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKG 1031
Query: 197 GSDGESSHGDGSE----LDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQ 252
++ DG + + D+ + D S +E+ + +S +S E+ + N
Sbjct: 1032 IKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSC-----DSSEDKKSKN-- 1084
Query: 253 DSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRD 312
G+ E K+ KS +D S + +M+E + NS D L R +
Sbjct: 1085 ---GAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKE------DGCNSSDKRLK--RIE 1133
Query: 313 SKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTT 372
+ SK N + +S + + ESS++ Q SS+ + +V E + ++ T
Sbjct: 1134 LRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSL--RT 1191
Query: 373 SYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENS--SSQ 430
S Q D SS S + + D ++S S+E P EN SS
Sbjct: 1192 STKRKQADITSSS-------------SSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSH 1238
Query: 431 EGL-QSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKS--SSEEDGQLKNIEIE 487
G QS A S+S ++DD D+ +R + E K+ SS+EDG + E
Sbjct: 1239 TGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1298
Query: 488 SRKLTVDAYHNKPIGDQD 505
+K T P GD++
Sbjct: 1299 GKKRTGKQNEENP-GDEE 1315
Score = 58.9 bits (141), Expect = 1e-08
Identities = 99/492 (20%), Positives = 191/492 (38%), Gaps = 44/492 (8%)
Query: 18 PVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLG 77
PVT + E ++ + K L+ P + + + + N+ P S QSE
Sbjct: 672 PVTSNSDEECNETVKEKQKLS---VPVRKKDKRNSSDSAIDNPKPNKLPK-SKQSETVDQ 727
Query: 78 SDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGD--DDSGPGPKDRQEGGNSRLG 135
+ D + + SR + D D +E + T D +G K +++ +S G
Sbjct: 728 NSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSG 787
Query: 136 SDEDSDDTIQASEESAPQGQDSAQDTTSE-SRELDNEDRVDSKPEGGDSTQE-------- 186
SD D+ A + + Q +S EL+ E + SK +T++
Sbjct: 788 SDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDF 847
Query: 187 --SESEEHWVGG----GSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK 240
SE E+H G G + +GS D E Q + E+ S G ++ M+ +
Sbjct: 848 DSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQ--ERETFSSAEGTVDKDTTIMELR 905
Query: 241 ESGENSEQANTQDSGGSQLL-EHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENS 299
+ +QA+ G +L + S +++E ++S+ T ++V+ +
Sbjct: 906 DRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLS--- 962
Query: 300 NSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEV 359
D ++D ++ ED K+ S++ ++ PS + + Q SS E
Sbjct: 963 ---DIAEKFLKKDQSDETSEDDKKQ-SKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEK 1018
Query: 360 VSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQAD-SESSESLNFSEES 418
+ E P ++ ++ + E S + S+ ++E +D +E S S +S
Sbjct: 1019 LPEREEICHFPKG--IKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDS 1076
Query: 419 PESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEED 478
E + +N + G + +S + SD++ S ++ NS+ D
Sbjct: 1077 SEDKKSKNGAY--GREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSS--------D 1126
Query: 479 GQLKNIEIESRK 490
+LK IE+ R+
Sbjct: 1127 KRLKRIELRERR 1138
Score = 45.1 bits (105), Expect = 2e-04
Identities = 72/336 (21%), Positives = 118/336 (35%), Gaps = 40/336 (11%)
Query: 160 DTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDD 219
D+ + + E++ +K GG+ + EE + E ++D + S
Sbjct: 470 DSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDL-----DMDIVSVPSSV 524
Query: 220 PESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDR 279
PE I + + + + G SG Q +E S K+ IS +D+R
Sbjct: 525 PEDIFENLETAMEVQSSVDHQGDGS---------SGTEQEVESSSVKL----NISSKDNR 571
Query: 280 SELDDNNTMEEVKS-------DSTENSNSRDTGLSQPRRD-----SKGDSQEDSKENLSQ 327
+ T + K S NS + + +D S G + + K L Q
Sbjct: 572 GGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQ 631
Query: 328 EESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEED 387
E S N +E S S S + + NP + S E E ++
Sbjct: 632 ENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKL 691
Query: 388 SSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGL--------QSHSSS 439
S K S + D+ L S++S D+NS S E L SHSSS
Sbjct: 692 SVPVRKKDKRNSSDSAIDNPKPNKLPKSKQS--ETVDQNSDSDEMLAILKEVSRMSHSSS 749
Query: 440 AESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSS 475
+++ E H+ + K+D + KSS+
Sbjct: 750 SDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSST 785
Score = 40.0 bits (92), Expect = 0.005
Identities = 85/444 (19%), Positives = 159/444 (35%), Gaps = 46/444 (10%)
Query: 45 LESSESSEGSKVSSEEQANEDPS-----DSTQSEEGLGSDD------HQYIYRLAGGFSR 93
++SS +G S EQ E S S + G+ S Y+ S
Sbjct: 538 VQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSN 597
Query: 94 STGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQ 153
S KG D ++ +D G + G PK + G LG + ++ + +E S
Sbjct: 598 SPIKGADCQEVPQDKDGYKS-----CGLNPKLEKCG----LGQENSDNEHLVENEVSL-- 646
Query: 154 GQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDE 213
E +L RV + P +E + V SD E + E E
Sbjct: 647 --------LLEESDLRRSPRVKTTP------LRRPTETNPVTSNSDEECN-----ETVKE 687
Query: 214 GMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRI 273
+ P + +R +S K + ++ + + S + +++ R S
Sbjct: 688 KQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHS 747
Query: 274 SEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNV 333
S D +++++ +T + D + D G + R+ S S D+K+ S + S
Sbjct: 748 SSSD--TDINEIHTNHKTLYDLKTQAGKDDKG-KRKRKSSTSGSDFDTKKGKSAKSSIIS 804
Query: 334 DGPSSESSQEANLSSQ-ENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTL 392
S+ +N S+ E +S ++ + P T + ED S++ +
Sbjct: 805 KKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQG 864
Query: 393 SHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEED 452
+ S+E +D + + S E D++++ E L+ + S + +
Sbjct: 865 HKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIME-LRDRLPKKQQASASTDGVDK 923
Query: 453 DSDSQDSSRSKEDSNSTESKSSSE 476
S + S S E E+K S+
Sbjct: 924 LSGKEQSFTSLEVRKVAETKEKSK 947
Score = 38.1 bits (87), Expect = 0.019
Identities = 67/321 (20%), Positives = 119/321 (37%), Gaps = 34/321 (10%)
Query: 221 ESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRS 280
+S +S + + K S N E+ DS + S I K I +
Sbjct: 301 DSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKLI 360
Query: 281 ELDDNNTMEEVK--SDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQN-----V 333
E N VK +T+NS + + K + K +L+ EE N +
Sbjct: 361 ETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAM 420
Query: 334 DGPSSESSQE------------ANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDS 381
D + E + + A + + E ++ SE++ + ++ +
Sbjct: 421 DAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPT 480
Query: 382 DSSEEDSSHTLSHSKSESREE--QADSESSESLNFSEESPES--PED--ENSSSQEGLQS 435
+ + S H KS+ +EE + +SE L+ S S PED EN + +QS
Sbjct: 481 EEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQS 540
Query: 436 HSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDA 495
S + E + S + + SK++ +SK++++ +L KLT +
Sbjct: 541 SVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKEL------YVKLTPVS 594
Query: 496 YHNKPIGDQDDNDC---QDGY 513
N PI D + +DGY
Sbjct: 595 LSNSPIKGADCQEVPQDKDGY 615
Score = 36.6 bits (83), Expect = 0.056
Identities = 37/164 (22%), Positives = 59/164 (35%), Gaps = 3/164 (1%)
Query: 316 DSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYV 375
+ +SK N ++ + SSE S+E SS + +Q G N D +
Sbjct: 4 EPMSESKLNTLVQKLHDFLAHSSEESEET--SSPPRLAMNQNTDKISGSGSNSDMMENSK 61
Query: 376 EDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQS 435
E+ S + S + S K + +S+ + L+ E E +ENS + +QS
Sbjct: 62 EEGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLD-DETVNEDASNENSENDITMQS 120
Query: 436 HSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDG 479
E ED D + TE+ EDG
Sbjct: 121 LPKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGEDG 164
Score = 36.2 bits (82), Expect = 0.073
Identities = 38/181 (20%), Positives = 63/181 (34%), Gaps = 30/181 (16%)
Query: 299 SNSRDTGLSQPRRDSKGDSQEDSKENLS------QEESQNVDGPSSESSQEANLSSQENS 352
S S+ L Q D S E+S+E S + + + G S S N + S
Sbjct: 7 SESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTS 66
Query: 353 SESQEEVVSESRGDN-PDPTTSYVEDQEDSDSSEEDSSHTLSHSKSES------------ 399
S + + SR P T YVE ++ +E + S+ SE+
Sbjct: 67 SSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTV 126
Query: 400 --------REEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEE 451
E++ D + E F S E+ ++GL S + +H ++
Sbjct: 127 IVQPEPVLNEDKDDFKGPE---FRSRSKMKTENLKKRGEDGLHGIVSCTACGQQVNHFQK 183
Query: 452 D 452
D
Sbjct: 184 D 184
Score = 35.4 bits (80), Expect = 0.13
Identities = 30/136 (22%), Positives = 61/136 (44%), Gaps = 19/136 (13%)
Query: 212 DEGMQSDDPESIRSERGNSRMNSAGMKS------KESGENSEQANTQDSGGSQLLEHPSR 265
+E ++ P + + +++ +G S KE G +S + ++ SG S+ PS
Sbjct: 27 EESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSE-KSKSSGSSRSKRKPSI 85
Query: 266 KIFRKSRISEEDDRSELDDNNTMEEVKSDSTEN-----SNSRDTGLSQPR---RDSKGDS 317
++ E DD LDD E+ ++++EN S + T + QP + K D
Sbjct: 86 V----TKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTVIVQPEPVLNEDKDDF 141
Query: 318 QEDSKENLSQEESQNV 333
+ + S+ +++N+
Sbjct: 142 KGPEFRSRSKMKTENL 157
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 71.2 bits (173), Expect = 2e-12
Identities = 84/387 (21%), Positives = 147/387 (37%), Gaps = 49/387 (12%)
Query: 134 LGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHW 193
+G ++DS E + + Q+ +E + L N D DSK DS +E E +H
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKR---DSLEEGELRDHC 57
Query: 194 VGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQD 253
+ + S + ++D G + DD +I+ + SR + E + + A ++
Sbjct: 58 MEI-TIRNSPYRREDSMEDRG-EEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKE 115
Query: 254 SGGSQLLEHPSRKIFRKS-----RISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQ 308
EH RK R+ R E R E+ ++ E +D R L +
Sbjct: 116 KER----EHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLER 171
Query: 309 PRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSS-ESQEEVVSESR--- 364
R + ++ ++ +E + + E +S+ + E + V S
Sbjct: 172 KRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSR 231
Query: 365 ------------GDNPDPTT----------SYVEDQEDSDSSEEDSSHTLSHSKSESREE 402
GD P S ++D DS+ + + + S S S EE
Sbjct: 232 SPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE 291
Query: 403 QADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS-- 460
+ + E E + E E E+E +E S+S A QS E SEE+ S+ ++
Sbjct: 292 EEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 351
Query: 461 -------RSKEDSNSTESKSSSEEDGQ 480
S+ D +S ES+ + EE G+
Sbjct: 352 NHLLVVPESRFDRDSGESEEAEEEVGE 378
Score = 63.5 bits (153), Expect = 4e-10
Identities = 84/386 (21%), Positives = 146/386 (37%), Gaps = 44/386 (11%)
Query: 99 GDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSA 158
GD+KD + + D+ + +++ E RL + +D D + EE + +D
Sbjct: 2 GDEKDSWKVKTLDEILQEKKRRKEQEEKAE--IKRLKNSDDRDSKRDSLEEG--ELRDHC 57
Query: 159 QDTTSESRELDNEDRVDSKPEGGDSTQ----ESESEEHWVGGGSDGESSHGDGSELDDEG 214
+ T + ED ++ + E DS + S + V D + + + ++
Sbjct: 58 MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKE 117
Query: 215 MQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQL---LEHPSRKIFRKS 271
+ + + R E+ +R K +E + + G LE RK R+
Sbjct: 118 REHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERER 177
Query: 272 RISE---------------EDDRSELD-------DNNTMEEVKSDSTENSNSRDTGLSQP 309
++ E E+ R E + + TM E SD + S+ + P
Sbjct: 178 KMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP 237
Query: 310 R-RDSKGDSQEDSKENLSQEESQNVD----GPSSESSQEANLSSQENSSESQEEVVSESR 364
R R GD ++ KE +E D S + A SS E+ S S+EE E
Sbjct: 238 RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE 297
Query: 365 GDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSE------SREEQADSESSESLNFSEES 418
+ T+ E++E+ + EE+ + + S SE S EE ++ E E+ N
Sbjct: 298 EEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVV 357
Query: 419 PESPEDENSSSQEGLQSHSSSAESQS 444
PES D +S E + QS
Sbjct: 358 PESRFDRDSGESEEAEEEVGEGTPQS 383
Score = 53.5 bits (127), Expect = 4e-07
Identities = 45/179 (25%), Positives = 82/179 (45%), Gaps = 25/179 (13%)
Query: 41 PTPPLESSESSEGSKVSSEEQANE-----DPSDSTQSEEGLGSDDHQYIYRLAGGFSRST 95
P PP E E +G K EE+ E D D + SE S A S +
Sbjct: 234 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSS---------AESSSAES 284
Query: 96 GKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQ 155
G G ++++++E++ ++ ++S ++ +E +E ++ +ASE+SA +
Sbjct: 285 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE------EEEETGSNSEEASEQSA---E 335
Query: 156 DSAQDTTSESRELDNEDRVDSKPEG--GDSTQESESEEHWVGGGSDGESSHGDGSELDD 212
+ +++ SE E +NE+ + PE + ESE E VG G+ S+ +G + D
Sbjct: 336 EVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPD 394
Score = 30.4 bits (67), Expect = 4.0
Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 8/95 (8%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQAN----EDPSDSTQSEEGLGS 78
+ E E+ EE +G ++ E E E S+ E+A+ E+ S+ SE+
Sbjct: 290 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 349
Query: 79 DDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDT 113
+++ + F R +G + ++ E++ G+ T
Sbjct: 350 NENHLLVVPESRFDRDSG----ESEEAEEEVGEGT 380
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 70.9 bits (172), Expect = 3e-12
Identities = 84/323 (26%), Positives = 129/323 (39%), Gaps = 31/323 (9%)
Query: 163 SESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPES 222
S SR R G + S+S G S + + S
Sbjct: 192 SRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRS--KKEKSRS 249
Query: 223 IRSERGNSRMNSAGM-KSKESGENSEQANTQDSGGSQLLEHPSR-KIFRKSRISEEDDRS 280
E+ SR +SAG +SK + E+ D+ G PSR K KSR ++ R
Sbjct: 250 PSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERR- 308
Query: 281 ELDDNNTMEEVKSDSTENSNSRDTGL--SQPRRDSKGDSQEDSKENLSQEESQNVDGPSS 338
+EE K S S++ L S+ R SKG S+ S+ ++ +
Sbjct: 309 -------VEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRK----GR 357
Query: 339 ESSQEANLSSQENSSESQEEVVSESRGDNPDPT--TSYVEDQEDSDSSEEDS-----SHT 391
+ S+E + S + S+S+ S RG D +S + +ED+D S+ S S
Sbjct: 358 KRSREESRSRSRSRSKSER---SRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKE 414
Query: 392 LSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEE 451
H+KSES + + E SE+ ++E+ S NS S+ L S S S + ++ S
Sbjct: 415 REHAKSESSQREGRGE-SENAGTNQET-RSRSRSNSKSKPNLPSESRSRSKSASKTRS-R 471
Query: 452 DDSDSQDSSRSKEDSNSTESKSS 474
S S+ +SRS S S S
Sbjct: 472 SKSRSRSASRSPSRSRSRSHSRS 494
Score = 68.6 bits (166), Expect = 1e-11
Identities = 86/397 (21%), Positives = 141/397 (35%), Gaps = 27/397 (6%)
Query: 111 DDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDN 170
D ++G SG G + G + G ++ + S+ +D ++ E+
Sbjct: 76 DGSYGSGRSGYGYR---RSGRDKYGPPTRTEYRLIVENLSSRCSWQDLKDYMRQAGEVTY 132
Query: 171 EDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNS 230
D + G S S+ DG +G L ++ S S R +S
Sbjct: 133 ADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHS 192
Query: 231 RMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEE 290
R S S++S S + + S SR SR S+ RS+ + E+
Sbjct: 193 RSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSR-----SR-SKSRSRSQSRSRSKKEK 246
Query: 291 VKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQE 350
+S S E S SR + R SK ++E + N NV P S S S+
Sbjct: 247 SRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNN------DNVGKPKSRSPSRHKSKSKS 300
Query: 351 NSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSE 410
S + V E RG + S QE S S + S+S SR + +
Sbjct: 301 RSRSQERRVEEEKRG-----SVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRK 355
Query: 411 SLNFSEESPESPEDENSSSQEGLQSHS-------SSAESQSEESHSEEDDSDSQDSSRSK 463
S E S S S+ + S SS + + E++ + S S+ S+ +
Sbjct: 356 GRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKER 415
Query: 464 EDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKP 500
E + S S+ + + E+R + +KP
Sbjct: 416 EHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKP 452
>gi|50962882 G patch domain containing 8 [Homo sapiens]
Length = 1502
Score = 70.5 bits (171), Expect = 4e-12
Identities = 87/430 (20%), Positives = 160/430 (37%), Gaps = 28/430 (6%)
Query: 70 TQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEG 129
T+ + +GS ++ L G + + G +K D + G ++QE
Sbjct: 589 TEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSG-LNKQEP 647
Query: 130 GNSRLGSDEDSDDTIQASEESAPQG-------QDSAQDTTSESRELDNEDRVDSKPEGGD 182
G S ED+ ++ + +E + + + + D E++ SK E G+
Sbjct: 648 GGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEK-SSKAESGE 706
Query: 183 STQESESEEHWVGGGS-DGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKE 241
+++ + + S +S G E G + P R + +S+ S +
Sbjct: 707 KSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAP-PRRRRRAQDDSQRRSLPAEEGS 765
Query: 242 SGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEED-------DRSELDDNNTMEEVKSD 294
SG+ E GGS +H RK K + RS + + +
Sbjct: 766 SGKKDE-----GGGGSSSQDHGGRK--HKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDE 818
Query: 295 STENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSE 354
+++++S P + S+ + +EDS S+ S++ SS S + SS ++S
Sbjct: 819 DSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDAS- 877
Query: 355 SQEEVVSESRGDNPDPTTSYVED--QEDSDSSEEDSSHTLSHSKSESREEQADSESSESL 412
S + S R + D + Y + + S + D S S R + + S+ SL
Sbjct: 878 SDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSL 937
Query: 413 NFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESK 472
+ S+ S S+ +S SSS + S + S SRS S ++
Sbjct: 938 SCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTR 997
Query: 473 SSSEEDGQLK 482
S S+ G K
Sbjct: 998 SPSQRSGSRK 1007
Score = 63.2 bits (152), Expect = 6e-10
Identities = 113/525 (21%), Positives = 195/525 (37%), Gaps = 52/525 (9%)
Query: 27 SEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSD-STQSEEGLGSDDHQYIY 85
S+ +E+ +++ P + S GSK +++ D SD S +S S+
Sbjct: 451 SQGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCES 510
Query: 86 RLAGGFSRSTGKGGDDKDDDEDDSGD--DTFGDDDSGP--GPKD-----RQEGGNSRLGS 136
+ S +T G + ++ + +G D+S P + + E S +
Sbjct: 511 NSSKETSLATPAGKESQEGPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCN 570
Query: 137 DEDSDDTIQASEESAPQGQDSAQDTTSESRE----LDNEDRVDSKPEGGDSTQESES--- 189
D + ++++ +G + +D S S++ LD + SK GG+ S
Sbjct: 571 PLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRM 630
Query: 190 EEHWVGGGSDG----ESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGEN 245
+ G G E GSE +D G S + G S + K K+S ++
Sbjct: 631 DAPASGSACSGLNKQEPGGSHGSETEDTGRSLP---SKKERSGKSHRHKKKKKHKKSSKH 687
Query: 246 SEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTG 305
+ S E + RK R +++ S D+ + E S
Sbjct: 688 KRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSE-----RGPKPEPPGSGSPA 742
Query: 306 LSQPRRDSKGDSQEDS---KENLSQEESQNVDGPSSE-------------SSQEANLSSQ 349
+ RR ++ DSQ S +E S ++ + G SS+ SS + ++
Sbjct: 743 PPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTK 802
Query: 350 ENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSS---EEDSSHTLSHSKSESRE-EQAD 405
+S S S D+ D ++ + + S S EE+ S + HS+S SR +
Sbjct: 803 RSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGS-EHSRSRSRSGRRHS 861
Query: 406 SESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEED-DSDSQDSSRSKE 464
S S ++S S S + S Q S S S HS+ DSD D + SK
Sbjct: 862 SHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKH 921
Query: 465 DSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDC 509
S SSS++D L + SR + ++ G + C
Sbjct: 922 RS-KRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSC 965
Score = 50.4 bits (119), Expect = 4e-06
Identities = 80/375 (21%), Positives = 135/375 (36%), Gaps = 43/375 (11%)
Query: 106 EDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSES 165
+DDS + ++ G KD EGG GS + E P T S
Sbjct: 751 QDDSQRRSLPAEEGSSGKKD--EGGG---GSSSQDHGGRKHKGELPPSSCQRRAGTKRSS 805
Query: 166 RELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRS 225
R S+P GD + S S + + E +D G + S
Sbjct: 806 RSSHR-----SQPSSGDEDSDDASSHRL---HQKSPSQYSEEEEEEDSGSEHSRSRSRSG 857
Query: 226 ERGNSRMNSAGMKSKESGENSEQA------NTQDSGGSQLLEHPSRKIFRKSRISEEDD- 278
R +S +S S S +S+Q+ + D S + SR+ ++S S++ D
Sbjct: 858 RRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDR-SRRHSKRSHDSDDSDY 916
Query: 279 -----RSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDS-KENLSQEESQN 332
RS+ ++ ++ S S S SR ++ R S+G S+ S + S+ S++
Sbjct: 917 ASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRS 976
Query: 333 VDGPSSESSQEANLSSQENSSESQEEVVSESRG---DNPDPTTSYVEDQEDSDSSEEDSS 389
S + S+ + ++ + S R ++P+ S D S S
Sbjct: 977 TTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSP 1036
Query: 390 HTLSHSKSESREEQADSESSES-------------LNFSEESPESPEDENSSSQEGLQSH 436
H + E ++ D +S E SPED+NS + + L
Sbjct: 1037 HYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEK 1096
Query: 437 SSSAESQSEESHSEE 451
S + + + S SEE
Sbjct: 1097 IQSRKVERKPSVSEE 1111
Score = 38.5 bits (88), Expect = 0.015
Identities = 65/320 (20%), Positives = 110/320 (34%), Gaps = 38/320 (11%)
Query: 179 EGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMK 238
EGG E + +E G+ +S G GSE + I + G ++ +
Sbjct: 226 EGG----EDDKDESATNSGTGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQAPGLASQ 281
Query: 239 SKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTEN 298
G + G S +K+ + E S D+ + + +
Sbjct: 282 GISFGIKNNLGTPLQKLGV------SFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPD 335
Query: 299 SNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEE 358
S D GL Q DS G S D K+ E+ Q+ +S S+ + +E + ++ E
Sbjct: 336 EKSSDQGL-QKVGDSDGSSNLDGKKE--DEDPQDGGSLASTLSKLKRMKREEGAGATEPE 392
Query: 359 V--------------------VSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSE 398
+ S + D TT E S + + S+
Sbjct: 393 YYHYIPPAHCKVKPNFPFLLFMRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQ 452
Query: 399 SREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEE-DDSDSQ 457
E+ S + S P P S E ++ QS ESHS++ ++
Sbjct: 453 GAEKTVSEVSEQPKETSMTEPSEP----GSKAEAKKALGGDVSDQSLESHSQKVSETQMC 508
Query: 458 DSSRSKEDSNSTESKSSSEE 477
+S+ SKE S +T + S+E
Sbjct: 509 ESNSSKETSLATPAGKESQE 528
Score = 35.4 bits (80), Expect = 0.13
Identities = 71/331 (21%), Positives = 118/331 (35%), Gaps = 49/331 (14%)
Query: 148 EESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDG 207
E A +D A++ TSE +KP+ S Q + G SDG SS+ DG
Sbjct: 313 ESIASVFKDHAEEGTSED---------GTKPDEKSSDQGLQKV-----GDSDG-SSNLDG 357
Query: 208 SELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKI 267
+ D++ S S+ MK +E +E + P+
Sbjct: 358 KKEDEDPQDGGSLASTLSKLKR-------MKREEGAGATEPEYYHYIPPAHCKVKPNFPF 410
Query: 268 FRKSRISEE-DDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLS 326
R SE+ D + N E K S + + SQ + + E KE
Sbjct: 411 LLFMRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSM 470
Query: 327 QEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYV-----EDQE-- 379
E S+ ++ + ++S Q S SQ+ ++ N TS E QE
Sbjct: 471 TEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGP 530
Query: 380 -------------DSDSSEEDSSHTLSHSKSESREEQA------DSESSESLNFSEESPE 420
D ++ + S L +K+E + D + S + + + E
Sbjct: 531 KHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTE 590
Query: 421 SPEDENSSSQEGLQSHSSSAESQSEESHSEE 451
P+D SSS++ LQ ++S+E E+
Sbjct: 591 KPKDIGSSSKDHLQGLDPGEPNKSKEVGGEK 621
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 69.3 bits (168), Expect = 8e-12
Identities = 118/500 (23%), Positives = 188/500 (37%), Gaps = 66/500 (13%)
Query: 17 LPVTRYQNNESEDSEEWKGHLAQAPTPPLESS--ESSEGSKVSSEEQANEDPSDSTQSEE 74
LP Q+ ED + K + + P PP + + G + + +E D S S Q +
Sbjct: 1298 LPSGTPQSLPKEDDKTTKT-IKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKS 1356
Query: 75 GLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDS----GDDTFGDDDSGPGPKDRQEGG 130
G D Y + G S S G+ DE D D+F + S P D +
Sbjct: 1357 PQGLSDTGYS---SDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLE 1413
Query: 131 NSRLG---------SDEDSDDTIQASEESAPQGQDSAQ-DTTSESRELD-NEDRVDSKPE 179
++ L +DE S+ Q E S Q +D + + SE+ E+ +E+ + E
Sbjct: 1414 STVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE 1473
Query: 180 GGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDP-ESIR--SERGNSRMNSAG 236
T + +S++ H + SE D+ +P +S+ SE NS +
Sbjct: 1474 ERKDTFKKDSQQD-----IPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRK 1528
Query: 237 MKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDD--NNTMEEVKSD 294
++ +S++ +DS GS E RK + E+ SE D+ N ++E+ S
Sbjct: 1529 RRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISS- 1587
Query: 295 STENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSS------ESSQEANLSS 348
STE+ +T KG L+++ S ++D + + EA S
Sbjct: 1588 STESQKKEET-------KGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDES 1640
Query: 349 QE------NSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREE 402
E S ES+E VV+ G T D S+E T + E E
Sbjct: 1641 PELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELE 1700
Query: 403 QADSESSESLNFSEESPESPEDENSSSQEGLQS-HSSSAESQSEESHSEEDDSDSQDSSR 461
E +SPED S EG S H+SS + + D DS S
Sbjct: 1701 M------------ESLTDSPEDR--SRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPS 1746
Query: 462 SKEDSNSTESKSSSEEDGQL 481
K+ + + K+ G L
Sbjct: 1747 HKKGESKQQRKARHRPHGPL 1766
Score = 53.5 bits (127), Expect = 4e-07
Identities = 72/386 (18%), Positives = 150/386 (38%), Gaps = 20/386 (5%)
Query: 117 DDSGPGPKDRQEGGNSRLGS-DEDSDDTIQASEESAPQGQDS--AQDTTSESRELDNEDR 173
++ P P+D++ ++ + +E D +++ + A + + A T E ++ + +
Sbjct: 1237 EEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQ--PQTK 1294
Query: 174 VDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMN 233
++ P G + E ++ + + + G + + E +S+ +S+
Sbjct: 1295 MEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQP 1354
Query: 234 SAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFR---KSRISEEDDRSELDDNNTMEE 290
+ ++G +S+ ++ L+ + I + K S+E S D +E
Sbjct: 1355 KSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLES 1414
Query: 291 VKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQE 350
E S L+ + + K E S E +E S + E +S +E
Sbjct: 1415 TVLSILEAQAST---LADEKSEKKTQPHEVSPEQPKDQEKTQ----SLSETLEITISEEE 1467
Query: 351 NSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSE 410
ESQEE + D+ S + +E S+ ++ ++ + E E +S +
Sbjct: 1468 -IKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQ 1526
Query: 411 SLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDS----SRSKEDS 466
+ S ++ +G Q E ++ED S S+D ++ KE S
Sbjct: 1527 RKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEIS 1586
Query: 467 NSTESKSSSEEDGQLKNIEIESRKLT 492
+STES+ E G+ K + R+LT
Sbjct: 1587 SSTESQKKEETKGKGKITAGKHRRLT 1612
Score = 51.2 bits (121), Expect = 2e-06
Identities = 111/484 (22%), Positives = 180/484 (37%), Gaps = 68/484 (14%)
Query: 13 LSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSES-SEGSKVSSEEQANEDPSDSTQ 71
LS L +T + E EE K + + SS+ E S+ + +P DS +
Sbjct: 1455 LSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVE 1514
Query: 72 -SEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDT---------FGDDDSGP 121
S E S Q R + G S S + K +D SG++ D+
Sbjct: 1515 ESSESENSPVPQRKRRTSVGSSSSD----EYKQEDSQGSGEEEDFIRKQIIEMSADEDAS 1570
Query: 122 GPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQD----TTSESRELD-------- 169
G +D + N + S Q EE+ +G+ +A T S +D
Sbjct: 1571 GSEDDEFIRNQL--KEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHS 1628
Query: 170 ----NEDRVDSKPE-GGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIR 224
+++ D PE T+ ESEE V GG G EL+ ES +
Sbjct: 1629 WHDEDDEAFDESPELKYRETKSQESEELVVTGG--GGLRRFKTIELNSTIADKYSAESSQ 1686
Query: 225 SERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDD 284
++ + + ES +S + ++ G S L + +S D+ S D
Sbjct: 1687 -KKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDS--DS 1743
Query: 285 NNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQE--DSKENLSQEESQNVDGPSSESSQ 342
+ + ++ +S + R G P + + +E + +E L ++E Q E Q
Sbjct: 1744 SPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQR------EIEQ 1797
Query: 343 EANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEE-DSSHTLSHSKSESRE 401
+ SS + S + ++E+ ++ R + P S + ED+ +EE + + S
Sbjct: 1798 QQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCS 1857
Query: 402 EQADSESSESLNFSEESPE------------------SPEDENSSSQ-EGLQSHSSSAES 442
E + S S+ F E SPE SP DE S Q EG Q SAE
Sbjct: 1858 EYSPSIESDPEGF-EISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQKALKSAEE 1916
Query: 443 QSEE 446
EE
Sbjct: 1917 MYEE 1920
Score = 30.8 bits (68), Expect = 3.1
Identities = 33/116 (28%), Positives = 46/116 (39%), Gaps = 7/116 (6%)
Query: 347 SSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHS------KSESR 400
SS + E ++ S S DN E E D + SS + S KS S
Sbjct: 4798 SSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQSPKPSVIKSRSH 4857
Query: 401 EEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDS 456
D + E+S SP SSS+ L+SH S SQS+ S ++ D+
Sbjct: 4858 GIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPS-RSQSKTSVTQTHLEDA 4912
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 69.3 bits (168), Expect = 8e-12
Identities = 118/500 (23%), Positives = 188/500 (37%), Gaps = 66/500 (13%)
Query: 17 LPVTRYQNNESEDSEEWKGHLAQAPTPPLESS--ESSEGSKVSSEEQANEDPSDSTQSEE 74
LP Q+ ED + K + + P PP + + G + + +E D S S Q +
Sbjct: 1298 LPSGTPQSLPKEDDKTTKT-IKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKS 1356
Query: 75 GLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDS----GDDTFGDDDSGPGPKDRQEGG 130
G D Y + G S S G+ DE D D+F + S P D +
Sbjct: 1357 PQGLSDTGYS---SDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLE 1413
Query: 131 NSRLG---------SDEDSDDTIQASEESAPQGQDSAQ-DTTSESRELD-NEDRVDSKPE 179
++ L +DE S+ Q E S Q +D + + SE+ E+ +E+ + E
Sbjct: 1414 STVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE 1473
Query: 180 GGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDP-ESIR--SERGNSRMNSAG 236
T + +S++ H + SE D+ +P +S+ SE NS +
Sbjct: 1474 ERKDTFKKDSQQD-----IPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRK 1528
Query: 237 MKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDD--NNTMEEVKSD 294
++ +S++ +DS GS E RK + E+ SE D+ N ++E+ S
Sbjct: 1529 RRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISS- 1587
Query: 295 STENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSS------ESSQEANLSS 348
STE+ +T KG L+++ S ++D + + EA S
Sbjct: 1588 STESQKKEET-------KGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDES 1640
Query: 349 QE------NSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREE 402
E S ES+E VV+ G T D S+E T + E E
Sbjct: 1641 PELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELE 1700
Query: 403 QADSESSESLNFSEESPESPEDENSSSQEGLQS-HSSSAESQSEESHSEEDDSDSQDSSR 461
E +SPED S EG S H+SS + + D DS S
Sbjct: 1701 M------------ESLTDSPEDR--SRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPS 1746
Query: 462 SKEDSNSTESKSSSEEDGQL 481
K+ + + K+ G L
Sbjct: 1747 HKKGESKQQRKARHRPHGPL 1766
Score = 53.5 bits (127), Expect = 4e-07
Identities = 72/386 (18%), Positives = 150/386 (38%), Gaps = 20/386 (5%)
Query: 117 DDSGPGPKDRQEGGNSRLGS-DEDSDDTIQASEESAPQGQDS--AQDTTSESRELDNEDR 173
++ P P+D++ ++ + +E D +++ + A + + A T E ++ + +
Sbjct: 1237 EEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQ--PQTK 1294
Query: 174 VDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMN 233
++ P G + E ++ + + + G + + E +S+ +S+
Sbjct: 1295 MEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQP 1354
Query: 234 SAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFR---KSRISEEDDRSELDDNNTMEE 290
+ ++G +S+ ++ L+ + I + K S+E S D +E
Sbjct: 1355 KSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLES 1414
Query: 291 VKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQE 350
E S L+ + + K E S E +E S + E +S +E
Sbjct: 1415 TVLSILEAQAST---LADEKSEKKTQPHEVSPEQPKDQEKTQ----SLSETLEITISEEE 1467
Query: 351 NSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSE 410
ESQEE + D+ S + +E S+ ++ ++ + E E +S +
Sbjct: 1468 -IKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQ 1526
Query: 411 SLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDS----SRSKEDS 466
+ S ++ +G Q E ++ED S S+D ++ KE S
Sbjct: 1527 RKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEIS 1586
Query: 467 NSTESKSSSEEDGQLKNIEIESRKLT 492
+STES+ E G+ K + R+LT
Sbjct: 1587 SSTESQKKEETKGKGKITAGKHRRLT 1612
Score = 51.2 bits (121), Expect = 2e-06
Identities = 111/484 (22%), Positives = 180/484 (37%), Gaps = 68/484 (14%)
Query: 13 LSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSES-SEGSKVSSEEQANEDPSDSTQ 71
LS L +T + E EE K + + SS+ E S+ + +P DS +
Sbjct: 1455 LSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVE 1514
Query: 72 -SEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDT---------FGDDDSGP 121
S E S Q R + G S S + K +D SG++ D+
Sbjct: 1515 ESSESENSPVPQRKRRTSVGSSSSD----EYKQEDSQGSGEEEDFIRKQIIEMSADEDAS 1570
Query: 122 GPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQD----TTSESRELD-------- 169
G +D + N + S Q EE+ +G+ +A T S +D
Sbjct: 1571 GSEDDEFIRNQL--KEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHS 1628
Query: 170 ----NEDRVDSKPE-GGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIR 224
+++ D PE T+ ESEE V GG G EL+ ES +
Sbjct: 1629 WHDEDDEAFDESPELKYRETKSQESEELVVTGG--GGLRRFKTIELNSTIADKYSAESSQ 1686
Query: 225 SERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDD 284
++ + + ES +S + ++ G S L + +S D+ S D
Sbjct: 1687 -KKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDS--DS 1743
Query: 285 NNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQE--DSKENLSQEESQNVDGPSSESSQ 342
+ + ++ +S + R G P + + +E + +E L ++E Q E Q
Sbjct: 1744 SPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQR------EIEQ 1797
Query: 343 EANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEE-DSSHTLSHSKSESRE 401
+ SS + S + ++E+ ++ R + P S + ED+ +EE + + S
Sbjct: 1798 QQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCS 1857
Query: 402 EQADSESSESLNFSEESPE------------------SPEDENSSSQ-EGLQSHSSSAES 442
E + S S+ F E SPE SP DE S Q EG Q SAE
Sbjct: 1858 EYSPSIESDPEGF-EISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQKALKSAEE 1916
Query: 443 QSEE 446
EE
Sbjct: 1917 MYEE 1920
Score = 30.8 bits (68), Expect = 3.1
Identities = 33/116 (28%), Positives = 46/116 (39%), Gaps = 7/116 (6%)
Query: 347 SSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHS------KSESR 400
SS + E ++ S S DN E E D + SS + S KS S
Sbjct: 4798 SSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQSPKPSVIKSRSH 4857
Query: 401 EEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDS 456
D + E+S SP SSS+ L+SH S SQS+ S ++ D+
Sbjct: 4858 GIFPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPS-RSQSKTSVTQTHLEDA 4912
>gi|157738619 smoothelin-like 1 [Homo sapiens]
Length = 512
Score = 69.3 bits (168), Expect = 8e-12
Identities = 83/387 (21%), Positives = 159/387 (41%), Gaps = 41/387 (10%)
Query: 135 GSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRV-------DSKPEGGDSTQES 187
G+ +SD + +A E+ + ++D T+ S DN + ++K G + E
Sbjct: 4 GAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEG 63
Query: 188 ESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSE 247
E G + G +EL E D+ + + ++ KE GE E
Sbjct: 64 PPTES--GKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEE 121
Query: 248 QA-NTQDSGG--SQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDT 304
+Q+ G + P ++S ++ E ++E +E K +S + +++ D
Sbjct: 122 TTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAE------EKEAKPESGQKADANDR 175
Query: 305 GLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSES- 363
+P K +E+ + SQEE+ S+E ++A + +E +ESQ+ VV +
Sbjct: 176 DKPEP----KATVEEEDAKTASQEETGQRKECSTEPKEKA--TDEEAKAESQKAVVEDEA 229
Query: 364 -----RGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESL----NF 414
D + +++ D+ ED+ S SE +E+ + E +
Sbjct: 230 KAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSS 289
Query: 415 SEESPESPEDE-NSSSQEGL----QSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNST 469
EE PESP E ++ S +GL + ++ S SE S S+ S + S ++ +
Sbjct: 290 PEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAP 349
Query: 470 ESKSSSEEDGQLKNIEIESRKLTVDAY 496
E + S+ + + ++RK VD +
Sbjct: 350 ERRVSA--PARPRGPRAQNRKAIVDKF 374
Score = 53.9 bits (128), Expect = 3e-07
Identities = 84/414 (20%), Positives = 159/414 (38%), Gaps = 49/414 (11%)
Query: 104 DDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTS 163
D+ + SG ++ G K EG + G +E AP + +
Sbjct: 38 DNPEMSGGGAPAEETKGTAGKAINEGPPTESGK-----------QEKAPAEDGMSAELQG 86
Query: 164 ESRELDNEDRVDSKPEGGDST--------QESESEEHWVGGGSDGESSHGDGSELDDEGM 215
E+ LD E +V+S+ E G ++ E EE VG + G E E
Sbjct: 87 EANGLD-EVKVESQREAGGKEDAEAELKKEDGEKEETTVGS----QEMTGRKEETKSEPK 141
Query: 216 QSDDPES-IRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRIS 274
++++ ES + SE+ + A ESG+ ++ + +E K +
Sbjct: 142 EAEEKESTLASEKQKAEEKEA---KPESGQKADANDRDKPEPKATVEEEDAKTASQEETG 198
Query: 275 EEDDRS-ELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNV 333
+ + S E + T EE K++S + + D ++P+ D +E++K +E
Sbjct: 199 QRKECSTEPKEKATDEEAKAES-QKAVVEDEAKAEPKEP---DGKEEAKHGAKEEAD--- 251
Query: 334 DGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLS 393
+ E +++A + + SE QE+ V + S E+ +S + E H LS
Sbjct: 252 ---AKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGE---GHNLS 305
Query: 394 HSK------SESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEES 447
+ + + SESS S + + PESP + + S+ A + +
Sbjct: 306 TDGLGPDCVASGQTSPSASESSPS-DVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRA 364
Query: 448 HSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPI 501
+ + D + S + +K++ G +KN+ +E + Y + I
Sbjct: 365 QNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDI 418
Score = 41.6 bits (96), Expect = 0.002
Identities = 46/237 (19%), Positives = 92/237 (38%), Gaps = 38/237 (16%)
Query: 46 ESSESSEGSK--VSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKD 103
E E++ GS+ +E+ +P ++ + E L S+ K ++
Sbjct: 118 EKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASE-----------------KQKAEEK 160
Query: 104 DDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTS 163
+ + +SG +D P PK E +++ S E++ + S E + D S
Sbjct: 161 EAKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAES 220
Query: 164 ESRELDNEDRVDSK-PEGGDSTQESESEEHWVGGGSDG--ESSHGDGSELDDEGMQSDD- 219
+ +++E + + K P+G + + EE ++ E+ G SE ++ ++ +
Sbjct: 221 QKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPE 280
Query: 220 -------------PESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHP 263
PES E N + G SG+ S A+ +S S + + P
Sbjct: 281 GGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSAS--ESSPSDVPQSP 335
Score = 37.7 bits (86), Expect = 0.025
Identities = 37/202 (18%), Positives = 77/202 (38%), Gaps = 13/202 (6%)
Query: 309 PRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNP 368
P + D +++E + Q+E + + ++ S N + ++E + + N
Sbjct: 3 PGAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINE 62
Query: 369 DPTTSYVEDQ----EDSDSSE-EDSSHTLSHSKSESREEQADSESSESLNFSEESPESPE 423
P T + + ED S+E + ++ L K ES+ E E +E+ E+ +
Sbjct: 63 GPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEET 122
Query: 424 DENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKN 483
S G + + S ++EE S + K+ + E+K S + +
Sbjct: 123 TVGSQEMTGRKEETKSEPKEAEEKEST--------LASEKQKAEEKEAKPESGQKADAND 174
Query: 484 IEIESRKLTVDAYHNKPIGDQD 505
+ K TV+ K ++
Sbjct: 175 RDKPEPKATVEEEDAKTASQEE 196
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 68.6 bits (166), Expect = 1e-11
Identities = 62/228 (27%), Positives = 95/228 (41%), Gaps = 27/228 (11%)
Query: 239 SKESGENSEQANTQDSGGSQLLEHPSRKIFRK--SRISEEDDRSELDDNNTMEEVKSDST 296
+K G +A SG L PS K+ RK S ISE + + EE + D
Sbjct: 867 AKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPE 926
Query: 297 ENSNSRDTG---LSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSS 353
+ + + G P+RD +E K +S +D E+SQE++ E
Sbjct: 927 QEKEAGEPGRPGTKPPKRD-----EERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDD 981
Query: 354 ESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQ-ADSESSESL 412
E EE E R + D T E + D + SS ++ S+ + +DSESS S
Sbjct: 982 EEDEE--DEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSS- 1038
Query: 413 NFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS 460
+SSS S SSS+ S S ES SE+++ + + ++
Sbjct: 1039 -------------SSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAA 1073
Score = 54.3 bits (129), Expect = 3e-07
Identities = 46/169 (27%), Positives = 68/169 (40%), Gaps = 12/169 (7%)
Query: 316 DSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDP-TTSY 374
++ E+ + S ++ D P E +EA + + + + E RG S+
Sbjct: 905 EASEEKRPRPSTPAEEDEDDPEQE--KEAGEPGRPGTKPPKRD---EERGKTQGKHRKSF 959
Query: 375 VEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 434
D E ++S+E SS E EE D E + E EDE S S
Sbjct: 960 ALDSEGEEASQESSSEK-DEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCS 1018
Query: 435 SHSSS-----AESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEED 478
++ S + S SE S S S S SS S S+S+ES S EE+
Sbjct: 1019 LYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEE 1067
Score = 50.1 bits (118), Expect = 5e-06
Identities = 39/175 (22%), Positives = 66/175 (37%), Gaps = 26/175 (14%)
Query: 346 LSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQA- 404
L S + + E+ S P P+T ED++D + +E +K R+E+
Sbjct: 890 LPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERG 949
Query: 405 ------------DSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEED 452
DSE E+ S + +DE E + + + ++E S E++
Sbjct: 950 KTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDE 1009
Query: 453 DSDSQ-------------DSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVD 494
+SDS DS+ E S+S+ S SSS + S + D
Sbjct: 1010 ESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSED 1064
Score = 47.4 bits (111), Expect = 3e-05
Identities = 46/178 (25%), Positives = 69/178 (38%), Gaps = 10/178 (5%)
Query: 182 DSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKE 241
+ ++ SE+ E S D E + E + P + +R R + G K
Sbjct: 899 EPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKS 958
Query: 242 SGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTME-EVKSDSTENSN 300
+SE S+ E + E++DR E D E EV E S+
Sbjct: 959 FALDSEGEEASQESSSEKDEEDDEED------EEDEDREEAVDTTKKETEVSDGEDEESD 1012
Query: 301 SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEE 358
S D + DS DS+ + S S + SS SS ++ SS E+SSE +EE
Sbjct: 1013 SSSKCSLYADSDGENDSTSDSESSSSSSSSSS---SSSSSSSSSSSSSSESSSEDEEE 1067
Score = 44.7 bits (104), Expect = 2e-04
Identities = 39/185 (21%), Positives = 76/185 (41%), Gaps = 13/185 (7%)
Query: 12 GLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQ 71
GL AL + ++ E SE + + P P + E + + E++A E T+
Sbjct: 883 GLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPE--QEKEAGEPGRPGTK 940
Query: 72 -----SEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDR 126
E G H+ + L ++ + +KD+++D+ ++ +++ K
Sbjct: 941 PPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKE 1000
Query: 127 QEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQE 186
E + G DE+SD + + S + G++ D+TS+S + S S+
Sbjct: 1001 TEVSD---GEDEESDSSSKCSLYADSDGEN---DSTSDSESSSSSSSSSSSSSSSSSSSS 1054
Query: 187 SESEE 191
S S E
Sbjct: 1055 SSSSE 1059
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/183 (24%), Positives = 65/183 (35%), Gaps = 14/183 (7%)
Query: 44 PLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKD 103
P E SE+SE + A ED D Q +E G R +G K
Sbjct: 900 PSEISEASEEKRPRPSTPAEEDEDDPEQEKEA-GEPGRPGTKPPKRDEERGKTQGKHRKS 958
Query: 104 DDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQAS--EESAPQGQDSAQDT 161
D G++ + S +D +E DED ++ + + E G+D D+
Sbjct: 959 FALDSEGEEASQESSSEKDEEDDEEDEE-----DEDREEAVDTTKKETEVSDGEDEESDS 1013
Query: 162 TSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPE 221
+S+ + D + DST +SES S SS S E D+ E
Sbjct: 1014 SSKCSLYADSDGEN------DSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEE 1067
Query: 222 SIR 224
R
Sbjct: 1068 EER 1070
Score = 44.3 bits (103), Expect = 3e-04
Identities = 40/162 (24%), Positives = 69/162 (42%), Gaps = 25/162 (15%)
Query: 100 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEG---GNSRLGSDEDSDDTIQASEESAPQGQD 156
+D+DD E + G + P +D + G G R DS+ +AS+ES+ + +
Sbjct: 920 EDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGE-EASQESSSEKDE 978
Query: 157 SAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSE-----LD 211
+D + + D E+ VD T + E+E SDGE D S D
Sbjct: 979 --EDDEEDEEDEDREEAVD--------TTKKETEV------SDGEDEESDSSSKCSLYAD 1022
Query: 212 DEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQD 253
+G +S S +S +S+ S S +S +++++D
Sbjct: 1023 SDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSED 1064
Score = 33.5 bits (75), Expect = 0.48
Identities = 30/122 (24%), Positives = 52/122 (42%), Gaps = 7/122 (5%)
Query: 355 SQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNF 414
SQ+ S SR D P + + S + + +T S + ++ A S S+ S +F
Sbjct: 244 SQDTSFSSSRQDTPSSFGQF------TPQSSQGTPYT-SRGSTPYSQDSAYSSSTTSTSF 296
Query: 415 SEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSS 474
E+ + S + S +S+ S + + + S S SS S+S+ S SS
Sbjct: 297 KPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSS 356
Query: 475 SE 476
S+
Sbjct: 357 SQ 358
Score = 31.2 bits (69), Expect = 2.4
Identities = 30/121 (24%), Positives = 51/121 (42%), Gaps = 13/121 (10%)
Query: 370 PTTSYVEDQEDSDSSEEDSSHT--LSHSKSESREEQA--DSESSESLNFSEESP------ 419
P VED E +++S+E LSH E A + + +L E P
Sbjct: 1269 PALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALF 1328
Query: 420 ESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDG 479
SP DE + E + + + + Q + EE + + ++ +E+ +S SSS DG
Sbjct: 1329 SSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSD---SSSSSDG 1385
Query: 480 Q 480
+
Sbjct: 1386 E 1386
Score = 29.3 bits (64), Expect = 9.0
Identities = 32/165 (19%), Positives = 64/165 (38%), Gaps = 7/165 (4%)
Query: 304 TGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSS-QENSSESQEEVVSE 362
+G + +S+ S D+ + + G + SQ+ + SS ++++ S + +
Sbjct: 207 SGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQ 266
Query: 363 SRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESP 422
S P + +DS S +S + +SE+ + A S S + + + +
Sbjct: 267 SSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTA 326
Query: 423 EDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSN 467
+++ + SSS S S S S S S D+N
Sbjct: 327 IAATTAATASSSASSSSLSSSSSSS------SSSSSSQFRSSDAN 365
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.292 0.115 0.300
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,980,388
Number of Sequences: 37866
Number of extensions: 1178788
Number of successful extensions: 27407
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 760
Number of HSP's successfully gapped in prelim test: 1518
Number of HSP's that attempted gapping in prelim test: 7164
Number of HSP's gapped (non-prelim): 10617
length of query: 513
length of database: 18,247,518
effective HSP length: 107
effective length of query: 406
effective length of database: 14,195,856
effective search space: 5763517536
effective search space used: 5763517536
T: 11
A: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 44 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.