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Search of human proteins with 4758062
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]
(422 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758062 cytokine receptor-like factor 1 [Homo sapiens] 888 0.0
gi|4506107 prolactin receptor [Homo sapiens] 125 6e-29
gi|28610149 interleukin 6 signal transducer isoform 2 precursor ... 122 6e-28
gi|28610147 interleukin 6 signal transducer isoform 1 precursor ... 122 6e-28
gi|115430248 gp130-like monocyte receptor [Homo sapiens] 86 8e-17
gi|27437045 colony stimulating factor 3 receptor isoform d precu... 82 7e-16
gi|24496783 colony stimulating factor 3 receptor isoform c precu... 82 7e-16
gi|27437042 colony stimulating factor 3 receptor isoform b precu... 82 7e-16
gi|4503081 colony stimulating factor 3 receptor isoform a precur... 82 7e-16
gi|22212918 ciliary neurotrophic factor receptor preproprotein [... 75 1e-13
gi|4502931 ciliary neurotrophic factor receptor preproprotein [H... 75 1e-13
gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens] 74 2e-13
gi|218505839 interleukin 11 receptor, alpha isoform 1 precursor ... 70 3e-12
gi|22212922 interleukin 11 receptor, alpha isoform 2 precursor [... 70 3e-12
gi|4758594 interleukin 11 receptor, alpha isoform 1 precursor [H... 70 3e-12
gi|4504673 interleukin 6 receptor isoform 1 precursor [Homo sapi... 67 3e-11
gi|31317249 interleukin 6 receptor isoform 2 precursor [Homo sap... 67 3e-11
gi|4504993 leukemia inhibitory factor receptor precursor [Homo s... 64 3e-10
gi|189083786 leukemia inhibitory factor receptor precursor [Homo... 64 3e-10
gi|24430212 interleukin 23 receptor precursor [Homo sapiens] 57 3e-08
gi|4503993 growth hormone receptor precursor [Homo sapiens] 56 5e-08
gi|4885491 myeloproliferative leukemia virus oncogene precursor ... 56 5e-08
gi|51093381 leptin receptor isoform 3 [Homo sapiens] 56 7e-08
gi|51093379 leptin receptor isoform 2 [Homo sapiens] 56 7e-08
gi|40254464 leptin receptor isoform 1 [Homo sapiens] 56 7e-08
gi|4503591 erythropoietin receptor precursor [Homo sapiens] 54 2e-07
gi|4504647 interleukin 13 receptor, alpha 1 precursor [Homo sapi... 53 6e-07
gi|14577917 Epstein-Barr virus induced 3 precursor [Homo sapiens] 52 8e-07
gi|10834992 interleukin 13 receptor, alpha 2 precursor [Homo sap... 50 4e-06
gi|5031785 interleukin 12 receptor, beta 1 isoform 1 precursor [... 50 5e-06
>gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]
Length = 422
Score = 888 bits (2294), Expect = 0.0
Identities = 422/422 (100%), Positives = 422/422 (100%)
Query: 1 MPAGRRGPAAQSARRPPPLLPLLLLLCVLGAPRAGSGAHTAVISPQDPTLLIGSSLLATC 60
MPAGRRGPAAQSARRPPPLLPLLLLLCVLGAPRAGSGAHTAVISPQDPTLLIGSSLLATC
Sbjct: 1 MPAGRRGPAAQSARRPPPLLPLLLLLCVLGAPRAGSGAHTAVISPQDPTLLIGSSLLATC 60
Query: 61 SVHGDPPGATAEGLYWTLNGRRLPPELSRVLNASTLALALANLNGSRQRSGDNLVCHARD 120
SVHGDPPGATAEGLYWTLNGRRLPPELSRVLNASTLALALANLNGSRQRSGDNLVCHARD
Sbjct: 61 SVHGDPPGATAEGLYWTLNGRRLPPELSRVLNASTLALALANLNGSRQRSGDNLVCHARD 120
Query: 121 GSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQ 180
GSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQ
Sbjct: 121 GSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQ 180
Query: 181 DNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPD 240
DNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPD
Sbjct: 181 DNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPD 240
Query: 241 VHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVEDSVDWKVVDDVSNQTSCRLAG 300
VHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVEDSVDWKVVDDVSNQTSCRLAG
Sbjct: 241 VHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVEDSVDWKVVDDVSNQTSCRLAG 300
Query: 301 LKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTPRSERPGPGGGACEPRGGEPSS 360
LKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTPRSERPGPGGGACEPRGGEPSS
Sbjct: 301 LKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTPRSERPGPGGGACEPRGGEPSS 360
Query: 361 GPVRRELKQFLGWLKKHAYCSNLSFRLYDQWRAWMQKSHKTRNQDEGILPSGRRGTARGP 420
GPVRRELKQFLGWLKKHAYCSNLSFRLYDQWRAWMQKSHKTRNQDEGILPSGRRGTARGP
Sbjct: 361 GPVRRELKQFLGWLKKHAYCSNLSFRLYDQWRAWMQKSHKTRNQDEGILPSGRRGTARGP 420
Query: 421 AR 422
AR
Sbjct: 421 AR 422
>gi|4506107 prolactin receptor [Homo sapiens]
Length = 622
Score = 125 bits (315), Expect = 6e-29
Identities = 83/224 (37%), Positives = 111/224 (49%), Gaps = 18/224 (8%)
Query: 123 ILAGSCLYVG-LPPEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQD 181
+ +CL G LPP KP C S N + TC W PG G L TNYSL Y
Sbjct: 15 LFLNTCLLNGQLPPGKPEIFKCRSPNKETFTCWWRPGTDGG--LPTNYSLTYHREGETLM 72
Query: 182 NTCEEYHTVGPHSCHIPKDL-ALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPD 240
+ C +Y T GP+SCH K +++ Y + V ATN++GS+ SD L +D+ +V DPP +
Sbjct: 73 HECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLE 132
Query: 241 VHVSRVGGLEDQLSVRWV--SPPALKDF---LFQAKYQIRYRVEDSVDWKVVDDVSNQTS 295
+ V V ED+ W+ SPP L D F Y+IR + E + +W+ + QT
Sbjct: 133 LAV-EVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWE-IHFAGQQTE 190
Query: 296 CRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTP 339
++ L PG Y VQVRC P G WS WS T P
Sbjct: 191 FKILSLHPGQKYLVQVRCKP-------DHGYWSAWSPATFIQIP 227
>gi|28610149 interleukin 6 signal transducer isoform 2 precursor
[Homo sapiens]
Length = 329
Score = 122 bits (306), Expect = 6e-28
Identities = 85/302 (28%), Positives = 136/302 (45%), Gaps = 17/302 (5%)
Query: 43 ISPQDPTLLIGSSLLATCSVHG---DPPGATAEGLYWTLNGRRLPPELSRVLNASTLALA 99
ISP+ P + + S+ A C + D A + W N +P E ++N + ++
Sbjct: 31 ISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVT 90
Query: 100 LANLNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGA 159
++ + N++ + + G + GLPPEKP N+SC K + C W G
Sbjct: 91 FTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGR 150
Query: 160 HGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGS 219
ET L TN++LK + + + + T P SC + F E+WVEA N LG
Sbjct: 151 --ETHLETNFTLKSEWATHKFADCKAKRDT--PTSCTVDYSTVYFVNIEVWVEAENALGK 206
Query: 220 ARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVE 279
SD + D + V +PP ++ V L L + W + P++K + KY I+YR +
Sbjct: 207 VTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTN-PSIKSVII-LKYNIQYRTK 264
Query: 280 DSVDWKVV---DDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAA 336
D+ W + D S ++S + LKP T Y ++RC G WS+WS +
Sbjct: 265 DASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRC-----MKEDGKGYWSDWSEEASG 319
Query: 337 ST 338
T
Sbjct: 320 IT 321
>gi|28610147 interleukin 6 signal transducer isoform 1 precursor
[Homo sapiens]
Length = 918
Score = 122 bits (306), Expect = 6e-28
Identities = 85/302 (28%), Positives = 136/302 (45%), Gaps = 17/302 (5%)
Query: 43 ISPQDPTLLIGSSLLATCSVHG---DPPGATAEGLYWTLNGRRLPPELSRVLNASTLALA 99
ISP+ P + + S+ A C + D A + W N +P E ++N + ++
Sbjct: 31 ISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVT 90
Query: 100 LANLNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGA 159
++ + N++ + + G + GLPPEKP N+SC K + C W G
Sbjct: 91 FTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGR 150
Query: 160 HGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGS 219
ET L TN++LK + + + + T P SC + F E+WVEA N LG
Sbjct: 151 --ETHLETNFTLKSEWATHKFADCKAKRDT--PTSCTVDYSTVYFVNIEVWVEAENALGK 206
Query: 220 ARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVE 279
SD + D + V +PP ++ V L L + W + P++K + KY I+YR +
Sbjct: 207 VTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTN-PSIKSVII-LKYNIQYRTK 264
Query: 280 DSVDWKVV---DDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAA 336
D+ W + D S ++S + LKP T Y ++RC G WS+WS +
Sbjct: 265 DASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRC-----MKEDGKGYWSDWSEEASG 319
Query: 337 ST 338
T
Sbjct: 320 IT 321
>gi|115430248 gp130-like monocyte receptor [Homo sapiens]
Length = 764
Score = 85.5 bits (210), Expect = 8e-17
Identities = 59/212 (27%), Positives = 96/212 (45%), Gaps = 19/212 (8%)
Query: 135 PEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPH- 193
P KP NISC K+LTC W+PG +T Y++K + + + C + +
Sbjct: 54 PAKPENISCVYYYRKNLTCTWSPGKETS---YTQYTVKRTYAFGEKHDNCTTNSSTSENR 110
Query: 194 ---SCHIPKDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLE 250
S +P+ + + Y I VEA N G +S + + ++ T+PP V V G++
Sbjct: 111 ASCSFFLPR-ITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGIK 169
Query: 251 DQLSVRWVSPPALKDFLFQAKYQIRYRVEDSVDWKVVDDVSNQ----TSCRLAGLKPGTV 306
+ + W+ P L KY +R+R +S W V+ N+ + L GL+P T
Sbjct: 170 RMIQIEWIK-PELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQPFTE 228
Query: 307 YFVQVRCNPFGIYGSKKAGIWSEWSHPTAAST 338
Y + +RC K++ WS+WS T
Sbjct: 229 YVIALRC------AVKESKFWSDWSQEKMGMT 254
>gi|27437045 colony stimulating factor 3 receptor isoform d
precursor [Homo sapiens]
Length = 783
Score = 82.4 bits (202), Expect = 7e-16
Identities = 94/323 (29%), Positives = 138/323 (42%), Gaps = 47/323 (14%)
Query: 35 GSGAHTAVISPQDPTLLIGSSLLATCSV-----HGDPPGATAEGLYWTLNGRRLPPELSR 89
GS IS P + +G + A+C + H DP + W L P +
Sbjct: 21 GSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ----ILWRLGAELQPGGRQQ 76
Query: 90 VLNASTLA--LALANLNGSRQRSGDNLVCHARDGS---ILAGSCLYVGLPPEKPVNISC- 143
L+ T + L +LN ++ L C G+ IL L G PP P N+SC
Sbjct: 77 RLSDGTQESIITLPHLNHTQAF----LSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCL 132
Query: 144 WSKNMKDLTCRWTPGAHGETFLHTNYSLK-YKLRWYGQ---DNTCEEYHTVGPHSCHIP- 198
+ L C+W PG ET L T+++LK +K R Q D+ + G C IP
Sbjct: 133 MNLTTSSLICQWEPGP--ETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPR 190
Query: 199 KDLALFTPYEIWVEATNRLGSARSDVLTLDILDVV--------TTDPPPDVHVSRVGGLE 250
K L L+ IWV+A N LG++ S L LD +DVV T DP P+ + G L+
Sbjct: 191 KHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQ 250
Query: 251 DQLSVRWVSPPALKDFLFQAKYQIRYRVE-DSVDWKVVDDVSNQT-SCRLAGLKPGTVYF 308
+ W P K ++R++ + W +V + + L GL P T Y
Sbjct: 251 ----LCW--EPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYT 304
Query: 309 VQVRCNPFGIYGSKKAGIWSEWS 331
+Q+RC + + G WS+WS
Sbjct: 305 LQIRCIRWPL-----PGHWSDWS 322
>gi|24496783 colony stimulating factor 3 receptor isoform c
precursor [Homo sapiens]
Length = 863
Score = 82.4 bits (202), Expect = 7e-16
Identities = 94/323 (29%), Positives = 138/323 (42%), Gaps = 47/323 (14%)
Query: 35 GSGAHTAVISPQDPTLLIGSSLLATCSV-----HGDPPGATAEGLYWTLNGRRLPPELSR 89
GS IS P + +G + A+C + H DP + W L P +
Sbjct: 21 GSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ----ILWRLGAELQPGGRQQ 76
Query: 90 VLNASTLA--LALANLNGSRQRSGDNLVCHARDGS---ILAGSCLYVGLPPEKPVNISC- 143
L+ T + L +LN ++ L C G+ IL L G PP P N+SC
Sbjct: 77 RLSDGTQESIITLPHLNHTQAF----LSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCL 132
Query: 144 WSKNMKDLTCRWTPGAHGETFLHTNYSLK-YKLRWYGQ---DNTCEEYHTVGPHSCHIP- 198
+ L C+W PG ET L T+++LK +K R Q D+ + G C IP
Sbjct: 133 MNLTTSSLICQWEPGP--ETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPR 190
Query: 199 KDLALFTPYEIWVEATNRLGSARSDVLTLDILDVV--------TTDPPPDVHVSRVGGLE 250
K L L+ IWV+A N LG++ S L LD +DVV T DP P+ + G L+
Sbjct: 191 KHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQ 250
Query: 251 DQLSVRWVSPPALKDFLFQAKYQIRYRVE-DSVDWKVVDDVSNQT-SCRLAGLKPGTVYF 308
+ W P K ++R++ + W +V + + L GL P T Y
Sbjct: 251 ----LCW--EPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYT 304
Query: 309 VQVRCNPFGIYGSKKAGIWSEWS 331
+Q+RC + + G WS+WS
Sbjct: 305 LQIRCIRWPL-----PGHWSDWS 322
>gi|27437042 colony stimulating factor 3 receptor isoform b
precursor [Homo sapiens]
Length = 769
Score = 82.4 bits (202), Expect = 7e-16
Identities = 94/323 (29%), Positives = 138/323 (42%), Gaps = 47/323 (14%)
Query: 35 GSGAHTAVISPQDPTLLIGSSLLATCSV-----HGDPPGATAEGLYWTLNGRRLPPELSR 89
GS IS P + +G + A+C + H DP + W L P +
Sbjct: 21 GSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ----ILWRLGAELQPGGRQQ 76
Query: 90 VLNASTLA--LALANLNGSRQRSGDNLVCHARDGS---ILAGSCLYVGLPPEKPVNISC- 143
L+ T + L +LN ++ L C G+ IL L G PP P N+SC
Sbjct: 77 RLSDGTQESIITLPHLNHTQAF----LSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCL 132
Query: 144 WSKNMKDLTCRWTPGAHGETFLHTNYSLK-YKLRWYGQ---DNTCEEYHTVGPHSCHIP- 198
+ L C+W PG ET L T+++LK +K R Q D+ + G C IP
Sbjct: 133 MNLTTSSLICQWEPGP--ETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPR 190
Query: 199 KDLALFTPYEIWVEATNRLGSARSDVLTLDILDVV--------TTDPPPDVHVSRVGGLE 250
K L L+ IWV+A N LG++ S L LD +DVV T DP P+ + G L+
Sbjct: 191 KHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQ 250
Query: 251 DQLSVRWVSPPALKDFLFQAKYQIRYRVE-DSVDWKVVDDVSNQT-SCRLAGLKPGTVYF 308
+ W P K ++R++ + W +V + + L GL P T Y
Sbjct: 251 ----LCW--EPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYT 304
Query: 309 VQVRCNPFGIYGSKKAGIWSEWS 331
+Q+RC + + G WS+WS
Sbjct: 305 LQIRCIRWPL-----PGHWSDWS 322
>gi|4503081 colony stimulating factor 3 receptor isoform a precursor
[Homo sapiens]
Length = 836
Score = 82.4 bits (202), Expect = 7e-16
Identities = 94/323 (29%), Positives = 138/323 (42%), Gaps = 47/323 (14%)
Query: 35 GSGAHTAVISPQDPTLLIGSSLLATCSV-----HGDPPGATAEGLYWTLNGRRLPPELSR 89
GS IS P + +G + A+C + H DP + W L P +
Sbjct: 21 GSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQ----ILWRLGAELQPGGRQQ 76
Query: 90 VLNASTLA--LALANLNGSRQRSGDNLVCHARDGS---ILAGSCLYVGLPPEKPVNISC- 143
L+ T + L +LN ++ L C G+ IL L G PP P N+SC
Sbjct: 77 RLSDGTQESIITLPHLNHTQAF----LSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCL 132
Query: 144 WSKNMKDLTCRWTPGAHGETFLHTNYSLK-YKLRWYGQ---DNTCEEYHTVGPHSCHIP- 198
+ L C+W PG ET L T+++LK +K R Q D+ + G C IP
Sbjct: 133 MNLTTSSLICQWEPGP--ETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPR 190
Query: 199 KDLALFTPYEIWVEATNRLGSARSDVLTLDILDVV--------TTDPPPDVHVSRVGGLE 250
K L L+ IWV+A N LG++ S L LD +DVV T DP P+ + G L+
Sbjct: 191 KHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQ 250
Query: 251 DQLSVRWVSPPALKDFLFQAKYQIRYRVE-DSVDWKVVDDVSNQT-SCRLAGLKPGTVYF 308
+ W P K ++R++ + W +V + + L GL P T Y
Sbjct: 251 ----LCW--EPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYT 304
Query: 309 VQVRCNPFGIYGSKKAGIWSEWS 331
+Q+RC + + G WS+WS
Sbjct: 305 LQIRCIRWPL-----PGHWSDWS 322
>gi|22212918 ciliary neurotrophic factor receptor preproprotein
[Homo sapiens]
Length = 372
Score = 75.1 bits (183), Expect = 1e-13
Identities = 81/281 (28%), Positives = 118/281 (41%), Gaps = 43/281 (15%)
Query: 76 WTLNGRRLPPELSRVLNASTLALALANLNGSRQRSGDNLVCHARDGSILAGSCL-YVGLP 134
W +NG L P+L LN S L L +G C RD L L +VGLP
Sbjct: 57 WRVNGTDLAPDL---LNGSQLVL-----HGLELGHSGLYACFHRDSWHLRHQVLLHVGLP 108
Query: 135 PEKPVNISCWSKNM-KDLTCRW-------TPGAHGETFLHTNYSLKYKLRWYGQDNTCEE 186
P +PV +SC S K C W P T LH + + CE+
Sbjct: 109 PREPV-LSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIM-----------VCEK 156
Query: 187 YHTVGPHSCHIPKDLALFTP--YEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVS 244
+ + CHI + + LF+ Y++ + +N LG + +T D +V DPP +V
Sbjct: 157 DPAL-KNRCHI-RYMHLFSTIKYKVSISVSNALGH-NATAITFDEFTIVKPDPPENVVAR 213
Query: 245 RVGGLEDQLSVRWVSPPALKD-FLFQAKYQIRYRVEDSVDWKVVDDVSNQTSCRLAGLKP 303
V +L V W +P D F K+ +RYR W+ V ++S+ T+ +
Sbjct: 214 PVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHV-ELSDGTAHTITDAYA 272
Query: 304 GTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTPRSERP 344
G Y +QV + G WS+WS A +TP +E P
Sbjct: 273 GKEYIIQVAAK------DNEIGTWSDWS-VAAHATPWTEEP 306
>gi|4502931 ciliary neurotrophic factor receptor preproprotein [Homo
sapiens]
Length = 372
Score = 75.1 bits (183), Expect = 1e-13
Identities = 81/281 (28%), Positives = 118/281 (41%), Gaps = 43/281 (15%)
Query: 76 WTLNGRRLPPELSRVLNASTLALALANLNGSRQRSGDNLVCHARDGSILAGSCL-YVGLP 134
W +NG L P+L LN S L L +G C RD L L +VGLP
Sbjct: 57 WRVNGTDLAPDL---LNGSQLVL-----HGLELGHSGLYACFHRDSWHLRHQVLLHVGLP 108
Query: 135 PEKPVNISCWSKNM-KDLTCRW-------TPGAHGETFLHTNYSLKYKLRWYGQDNTCEE 186
P +PV +SC S K C W P T LH + + CE+
Sbjct: 109 PREPV-LSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIM-----------VCEK 156
Query: 187 YHTVGPHSCHIPKDLALFTP--YEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVS 244
+ + CHI + + LF+ Y++ + +N LG + +T D +V DPP +V
Sbjct: 157 DPAL-KNRCHI-RYMHLFSTIKYKVSISVSNALGH-NATAITFDEFTIVKPDPPENVVAR 213
Query: 245 RVGGLEDQLSVRWVSPPALKD-FLFQAKYQIRYRVEDSVDWKVVDDVSNQTSCRLAGLKP 303
V +L V W +P D F K+ +RYR W+ V ++S+ T+ +
Sbjct: 214 PVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHV-ELSDGTAHTITDAYA 272
Query: 304 GTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTPRSERP 344
G Y +QV + G WS+WS A +TP +E P
Sbjct: 273 GKEYIIQVAAK------DNEIGTWSDWS-VAAHATPWTEEP 306
>gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]
Length = 862
Score = 73.9 bits (180), Expect = 2e-13
Identities = 68/239 (28%), Positives = 104/239 (43%), Gaps = 25/239 (10%)
Query: 114 LVCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMK-DLTCRWTPGAHGETFLHTNYSLK 172
L C D + G+ ++VG+ PE+P N+SC K + + C W G +T L+T Y+L+
Sbjct: 103 LACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGR--DTHLYTEYTLQ 160
Query: 173 Y----KLRWYGQ--DNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGSARSDVLT 226
L W Q D C +Y G + + + + V A N LGS+ S T
Sbjct: 161 LSGPKNLTWQKQCKDIYC-DYLDFGINLTPESPE----SNFTAKVTAVNSLGSSSSLPST 215
Query: 227 LDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVEDSVDWKV 286
LD+V PP D+ + + ++ W +D ++RYR +S W +
Sbjct: 216 FTFLDIVRPLPPWDIRIKFQKASVSRCTLYW------RDEGLVLLNRLRYRPSNSRLWNM 269
Query: 287 VDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTPRSERPG 345
V+ + L LKP T Y Q+ + +Y G WS+WS A TP E G
Sbjct: 270 VNVTKAKGRHDLLDLKPFTEYEFQI-SSKLHLY----KGSWSDWSESLRAQTPEEEPTG 323
>gi|218505839 interleukin 11 receptor, alpha isoform 1 precursor
[Homo sapiens]
Length = 422
Score = 70.5 bits (171), Expect = 3e-12
Identities = 62/239 (25%), Positives = 100/239 (41%), Gaps = 30/239 (12%)
Query: 115 VCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYK 174
+C DG++ L +G PP +PV +SC + + ++ +C W+P + L T Y Y+
Sbjct: 93 ICQTLDGALGGTVTLQLGYPPARPV-VSCQAADYENFSCTWSPSQ--ISGLPTRYLTSYR 149
Query: 175 LRWYGQDNTCEEYHTVGPHSCHIPKD-----------LALFTPYEIWVEATNRLGSARSD 223
+ ++ + GP C P+D ++ Y I V N LG A +
Sbjct: 150 KKTVLGADSQRRSPSTGPWPC--PQDPLGAARCVVHGAEFWSQYRINVTEVNPLG-ASTR 206
Query: 224 VLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSP---PALKDFLFQAKYQIRYRVED 280
+L + + ++ DPP + V V G +L W P P FL K++++YR
Sbjct: 207 LLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLL--KFRLQYRPAQ 264
Query: 281 SVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTP 339
W V+ + + G + V+V F AG WS WS P A TP
Sbjct: 265 HPAWSTVEPAGLEEV--ITDAVAGLPHAVRVSARDF-----LDAGTWSTWS-PEAWGTP 315
>gi|22212922 interleukin 11 receptor, alpha isoform 2 precursor
[Homo sapiens]
Length = 390
Score = 70.5 bits (171), Expect = 3e-12
Identities = 62/239 (25%), Positives = 100/239 (41%), Gaps = 30/239 (12%)
Query: 115 VCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYK 174
+C DG++ L +G PP +PV +SC + + ++ +C W+P + L T Y Y+
Sbjct: 93 ICQTLDGALGGTVTLQLGYPPARPV-VSCQAADYENFSCTWSPSQ--ISGLPTRYLTSYR 149
Query: 175 LRWYGQDNTCEEYHTVGPHSCHIPKD-----------LALFTPYEIWVEATNRLGSARSD 223
+ ++ + GP C P+D ++ Y I V N LG A +
Sbjct: 150 KKTVLGADSQRRSPSTGPWPC--PQDPLGAARCVVHGAEFWSQYRINVTEVNPLG-ASTR 206
Query: 224 VLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSP---PALKDFLFQAKYQIRYRVED 280
+L + + ++ DPP + V V G +L W P P FL K++++YR
Sbjct: 207 LLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLL--KFRLQYRPAQ 264
Query: 281 SVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTP 339
W V+ + + G + V+V F AG WS WS P A TP
Sbjct: 265 HPAWSTVEPAGLEEV--ITDAVAGLPHAVRVSARDF-----LDAGTWSTWS-PEAWGTP 315
>gi|4758594 interleukin 11 receptor, alpha isoform 1 precursor [Homo
sapiens]
Length = 422
Score = 70.5 bits (171), Expect = 3e-12
Identities = 62/239 (25%), Positives = 100/239 (41%), Gaps = 30/239 (12%)
Query: 115 VCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYK 174
+C DG++ L +G PP +PV +SC + + ++ +C W+P + L T Y Y+
Sbjct: 93 ICQTLDGALGGTVTLQLGYPPARPV-VSCQAADYENFSCTWSPSQ--ISGLPTRYLTSYR 149
Query: 175 LRWYGQDNTCEEYHTVGPHSCHIPKD-----------LALFTPYEIWVEATNRLGSARSD 223
+ ++ + GP C P+D ++ Y I V N LG A +
Sbjct: 150 KKTVLGADSQRRSPSTGPWPC--PQDPLGAARCVVHGAEFWSQYRINVTEVNPLG-ASTR 206
Query: 224 VLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSP---PALKDFLFQAKYQIRYRVED 280
+L + + ++ DPP + V V G +L W P P FL K++++YR
Sbjct: 207 LLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLL--KFRLQYRPAQ 264
Query: 281 SVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTP 339
W V+ + + G + V+V F AG WS WS P A TP
Sbjct: 265 HPAWSTVEPAGLEEV--ITDAVAGLPHAVRVSARDF-----LDAGTWSTWS-PEAWGTP 315
>gi|4504673 interleukin 6 receptor isoform 1 precursor [Homo
sapiens]
Length = 468
Score = 67.0 bits (162), Expect = 3e-11
Identities = 84/335 (25%), Positives = 126/335 (37%), Gaps = 32/335 (9%)
Query: 22 LLLLLCVLGAPRAGSGAHTAVISPQDPTLLIGSSLLATCSVHGDPPGATAEG---LYWTL 78
L LL GA A ++ T L G S+ TC PG E ++W L
Sbjct: 9 LAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTC------PGVEPEDNATVHWVL 62
Query: 79 NGRRLPPELSRVLNASTLALALANLNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKP 138
SR L L + N C+ R G L V +PPE+P
Sbjct: 63 RKPAAGSHPSRWAGMGRRLL----LRSVQLHDSGNYSCY-RAGRPAGTVHLLVDVPPEEP 117
Query: 139 VNISCWSKN-MKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQD--NTCEEYHTVGPHSC 195
+SC+ K+ + ++ C W P + ++ +D C+ SC
Sbjct: 118 -QLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSC 176
Query: 196 HIPKDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSV 255
+ + Y + + + +GS S T ++ DPP ++ V+ V LSV
Sbjct: 177 QLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSV 236
Query: 256 RWVSPPALKDFLFQAKYQIRYRVEDS---VDWKVVDDVSNQTSCRLAGLKPGTVYFVQVR 312
W P + ++ ++++RYR E S W V D Q C + G + VQ+R
Sbjct: 237 TWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKD---LQHHCVIHDAWSGLRHVVQLR 293
Query: 313 C-NPFGIYGSKKAGIWSEWSHPTAASTPRSERPGP 346
FG G WSEWS P A TP +E P
Sbjct: 294 AQEEFG------QGEWSEWS-PEAMGTPWTESRSP 321
>gi|31317249 interleukin 6 receptor isoform 2 precursor [Homo
sapiens]
Length = 365
Score = 67.0 bits (162), Expect = 3e-11
Identities = 84/335 (25%), Positives = 126/335 (37%), Gaps = 32/335 (9%)
Query: 22 LLLLLCVLGAPRAGSGAHTAVISPQDPTLLIGSSLLATCSVHGDPPGATAEG---LYWTL 78
L LL GA A ++ T L G S+ TC PG E ++W L
Sbjct: 9 LAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTC------PGVEPEDNATVHWVL 62
Query: 79 NGRRLPPELSRVLNASTLALALANLNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKP 138
SR L L + N C+ R G L V +PPE+P
Sbjct: 63 RKPAAGSHPSRWAGMGRRLL----LRSVQLHDSGNYSCY-RAGRPAGTVHLLVDVPPEEP 117
Query: 139 VNISCWSKN-MKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQD--NTCEEYHTVGPHSC 195
+SC+ K+ + ++ C W P + ++ +D C+ SC
Sbjct: 118 -QLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSC 176
Query: 196 HIPKDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSV 255
+ + Y + + + +GS S T ++ DPP ++ V+ V LSV
Sbjct: 177 QLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSV 236
Query: 256 RWVSPPALKDFLFQAKYQIRYRVEDS---VDWKVVDDVSNQTSCRLAGLKPGTVYFVQVR 312
W P + ++ ++++RYR E S W V D Q C + G + VQ+R
Sbjct: 237 TWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKD---LQHHCVIHDAWSGLRHVVQLR 293
Query: 313 C-NPFGIYGSKKAGIWSEWSHPTAASTPRSERPGP 346
FG G WSEWS P A TP +E P
Sbjct: 294 AQEEFG------QGEWSEWS-PEAMGTPWTESRSP 321
>gi|4504993 leukemia inhibitory factor receptor precursor [Homo
sapiens]
Length = 1097
Score = 63.5 bits (153), Expect = 3e-10
Identities = 71/310 (22%), Positives = 131/310 (42%), Gaps = 41/310 (13%)
Query: 43 ISPQDPTLLIGSSLLATCSVHGDPPGATAEGLYWTLNGRRLPPELSRVLNASTLALALAN 102
+ PQD +L+GS + C + E + L G P + L+ +A+ + N
Sbjct: 254 VFPQDKVILVGSDITFCC--------VSQEKVLSALIGHTNCPLIH--LDGENVAIKIRN 303
Query: 103 LNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPG---- 158
++ S SG N+V D + G+ ++ G PP+ P ++C + ++K++ C W PG
Sbjct: 304 ISVSAS-SGTNVVFTTEDN--IFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA 360
Query: 159 -----AHGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEA 213
A T + ++S KY + T E Y + + L Y + A
Sbjct: 361 LVGPRATSYTLVE-SFSGKYVRLKRAEAPTNESYQL-------LFQMLPNQEIYNFTLNA 412
Query: 214 TNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQ 273
N LG ++S +L ++I + V P V + +LS A +FL + + +
Sbjct: 413 HNPLGRSQSTIL-VNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIK 471
Query: 274 IRYRVEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWS-- 331
V++ + + ++ L L P T+Y ++RC+ ++ WS+WS
Sbjct: 472 KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCS------TETFWKWSKWSNK 525
Query: 332 --HPTAASTP 339
H T ++P
Sbjct: 526 KQHLTTEASP 535
>gi|189083786 leukemia inhibitory factor receptor precursor [Homo
sapiens]
Length = 1097
Score = 63.5 bits (153), Expect = 3e-10
Identities = 71/310 (22%), Positives = 131/310 (42%), Gaps = 41/310 (13%)
Query: 43 ISPQDPTLLIGSSLLATCSVHGDPPGATAEGLYWTLNGRRLPPELSRVLNASTLALALAN 102
+ PQD +L+GS + C + E + L G P + L+ +A+ + N
Sbjct: 254 VFPQDKVILVGSDITFCC--------VSQEKVLSALIGHTNCPLIH--LDGENVAIKIRN 303
Query: 103 LNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPG---- 158
++ S SG N+V D + G+ ++ G PP+ P ++C + ++K++ C W PG
Sbjct: 304 ISVSAS-SGTNVVFTTEDN--IFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA 360
Query: 159 -----AHGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEA 213
A T + ++S KY + T E Y + + L Y + A
Sbjct: 361 LVGPRATSYTLVE-SFSGKYVRLKRAEAPTNESYQL-------LFQMLPNQEIYNFTLNA 412
Query: 214 TNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQ 273
N LG ++S +L ++I + V P V + +LS A +FL + + +
Sbjct: 413 HNPLGRSQSTIL-VNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIK 471
Query: 274 IRYRVEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWS-- 331
V++ + + ++ L L P T+Y ++RC+ ++ WS+WS
Sbjct: 472 KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCS------TETFWKWSKWSNK 525
Query: 332 --HPTAASTP 339
H T ++P
Sbjct: 526 KQHLTTEASP 535
>gi|24430212 interleukin 23 receptor precursor [Homo sapiens]
Length = 629
Score = 57.0 bits (136), Expect = 3e-08
Identities = 56/230 (24%), Positives = 91/230 (39%), Gaps = 31/230 (13%)
Query: 122 SILAGSCLYVGLPPEKPVNISC----WSKNMKDLTCRWTPGAHGETFLHTNYSLKYKLRW 177
+++ G + G PP+ P ++C +S NM TC W G T++ T Y + K
Sbjct: 112 TLICGKDISSGYPPDIPDEVTCVIYEYSGNM---TCTWNAGKL--TYIDTKYVVHVKSL- 165
Query: 178 YGQDNTCEEYHTVGPHSCHIPKD-LALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTD 236
T EE + +I D L Y +WV+A N LG S L + + D+V
Sbjct: 166 ----ETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPS 221
Query: 237 PPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVEDSVDWKVVDDVSNQTSC 296
+ + + W S ++ + ++RY+ + W V + +N T
Sbjct: 222 AAVISRAETINATVPKTIIYWDSQTTIE----KVSCEMRYKATTNQTWNVKEFDTNFTYV 277
Query: 297 RLAG--LKPGTVYFVQVRCNPFGIYGSKKAGIWSEWS----HPTAASTPR 340
+ + L+P Y QVRC G W WS H T + P+
Sbjct: 278 QQSEFYLEPNIKYVFQVRCQETG------KRYWQPWSSLFFHKTPETVPQ 321
>gi|4503993 growth hormone receptor precursor [Homo sapiens]
Length = 638
Score = 56.2 bits (134), Expect = 5e-08
Identities = 46/216 (21%), Positives = 95/216 (43%), Gaps = 22/216 (10%)
Query: 136 EKPVNISCWSKNMKDLTCRWTPGAHGETF----LHTNYSLKYKLRWYGQDNTCEEYHTVG 191
++P C S + +C WT H T + Y+ + W + C +Y + G
Sbjct: 49 KEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAG 108
Query: 192 PHSCHIPKDL-ALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVG--- 247
+SC+ +++ PY ++ T+ G+ ++D ++V DPP ++ + +
Sbjct: 109 ENSCYFNSSFTSIWIPY--CIKLTSNGGTVDEKCFSVD--EIVQPDPPIALNWTLLNVSL 164
Query: 248 -GLEDQLSVRWVSP--PALKDFLFQAKYQIRYRVEDSVDWKVVDDVSNQTSCRLAGLKPG 304
G+ + VRW +P ++ +Y+++Y+ + WK++D + TS + LK
Sbjct: 165 TGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILT-TSVPVYSLKVD 223
Query: 305 TVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTPR 340
Y V+VR + +G + E+S + P+
Sbjct: 224 KEYEVRVRSK------QRNSGNYGEFSEVLYVTLPQ 253
>gi|4885491 myeloproliferative leukemia virus oncogene precursor
[Homo sapiens]
Length = 635
Score = 56.2 bits (134), Expect = 5e-08
Identities = 60/257 (23%), Positives = 90/257 (35%), Gaps = 71/257 (27%)
Query: 141 ISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPH-----SC 195
+ C+S+ +DLTC W E Y L Y + C PH C
Sbjct: 38 LKCFSRTFEDLTCFWD---EEEAAPSGTYQLLYAYP-REKPRACPLSSQSMPHFGTRYVC 93
Query: 196 HIP--KDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQL 253
P +++ LF P +WV+ + VL +D V PP + + G +L
Sbjct: 94 QFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVL---FVDSVGLPAPPSIIKAMGGSQPGEL 150
Query: 254 SVRWVSP-PALKDFLFQAKYQIRYRVED---SVDWKVVDDVSNQT--------------- 294
+ W P P + DFL +Y++RY D S V+ ++ +T
Sbjct: 151 QISWEEPAPEISDFL---RYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALD 207
Query: 295 --------------------------------SCRLAGLKPGTVYFVQVRCNPFGIYGSK 322
SC ++GL+PG Y++Q+R P GI
Sbjct: 208 QSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGI---S 264
Query: 323 KAGIWSEWSHPTAASTP 339
G W WS P P
Sbjct: 265 LGGSWGSWSLPVTVDLP 281
Score = 55.8 bits (133), Expect = 7e-08
Identities = 60/236 (25%), Positives = 94/236 (39%), Gaps = 28/236 (11%)
Query: 120 DGSILAGSC------LYVGLPPEK-PVNISCWSKNMKDLTCRWTPGAHGET---FLHTNY 169
DG L GS + V LP + + + C++ ++K++TC+W H + F H+
Sbjct: 261 DGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRA 320
Query: 170 SLKYKLRWYGQDNTCEEYHTVGP-------HSCHIPKDLALFTPYEIWVEATNRLGSARS 222
+ R+ +N CEE P CH I VE T G+ S
Sbjct: 321 RCCPRDRYPIWEN-CEEEEKTNPGLQTPQFSRCHFKSRNDSII--HILVEVTTAPGTVHS 377
Query: 223 DVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVEDSV 282
+ + + P P++H + L + W P + + YQ+RY E
Sbjct: 378 YLGSPFWIHQAVRLPTPNLHWREISS--GHLELEWQHPSSWA--AQETCYQLRYTGEGHQ 433
Query: 283 DWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAAST 338
DWKV++ L L+P + Y +Q+R + G G WS WS PT T
Sbjct: 434 DWKVLEPPLGARGGTLE-LRPRSRYRLQLRAR---LNGPTYQGPWSSWSDPTRVET 485
>gi|51093381 leptin receptor isoform 3 [Homo sapiens]
Length = 958
Score = 55.8 bits (133), Expect = 7e-08
Identities = 72/304 (23%), Positives = 121/304 (39%), Gaps = 41/304 (13%)
Query: 52 IGSSLLATCSVHGDPPGATAEGLYWTLN-GRRLPPELSRVLNASTLALALANLNGSRQRS 110
+GS++ C + ++ + W +N ++P V++ + NLN ++ R
Sbjct: 344 VGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRG 403
Query: 111 G---DNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKN-MKDLTCRWTPGAHGETFLH 166
D + C + LYV + +NISC + + +TCRW+ +
Sbjct: 404 KFTYDAVYCCNEHECHHRYAELYV---IDVNINISCETDGYLTKMTCRWSTST-----IQ 455
Query: 167 TNYSLKYKLRWYGQDNTCEEYHTVGPHS----CHIPKD---------LALFTPYEIWVEA 213
+ +LR++ C + ++ P S C++ D + L + Y +W+
Sbjct: 456 SLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRI 515
Query: 214 TNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQ 273
+ LGS S T + D V PP + + L + W P ++ L ++Q
Sbjct: 516 NHSLGSLDSPP-TCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNL---QFQ 571
Query: 274 IRYRVEDS-VDWK---VVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSE 329
IRY + V WK V D S S + L VY VQVRC G WS
Sbjct: 572 IRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLC--AVYAVQVRCKRLD-----GLGYWSN 624
Query: 330 WSHP 333
WS+P
Sbjct: 625 WSNP 628
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/118 (27%), Positives = 58/118 (49%), Gaps = 10/118 (8%)
Query: 221 RSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVED 280
+S ++++ +++V DPP +H+ + L + W SPP + F +YQ++Y
Sbjct: 223 QSPLMSVQPINMVKPDPPLGLHMEITD--DGNLKISWSSPPLVP---FPLQYQVKYSENS 277
Query: 281 SVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAAST 338
+ + D + + TS + + PG+ Y VQVR GIWS+WS P +T
Sbjct: 278 TTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRL-----DGPGIWSDWSTPRVFTT 330
>gi|51093379 leptin receptor isoform 2 [Homo sapiens]
Length = 896
Score = 55.8 bits (133), Expect = 7e-08
Identities = 72/304 (23%), Positives = 121/304 (39%), Gaps = 41/304 (13%)
Query: 52 IGSSLLATCSVHGDPPGATAEGLYWTLN-GRRLPPELSRVLNASTLALALANLNGSRQRS 110
+GS++ C + ++ + W +N ++P V++ + NLN ++ R
Sbjct: 344 VGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRG 403
Query: 111 G---DNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKN-MKDLTCRWTPGAHGETFLH 166
D + C + LYV + +NISC + + +TCRW+ +
Sbjct: 404 KFTYDAVYCCNEHECHHRYAELYV---IDVNINISCETDGYLTKMTCRWSTST-----IQ 455
Query: 167 TNYSLKYKLRWYGQDNTCEEYHTVGPHS----CHIPKD---------LALFTPYEIWVEA 213
+ +LR++ C + ++ P S C++ D + L + Y +W+
Sbjct: 456 SLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRI 515
Query: 214 TNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQ 273
+ LGS S T + D V PP + + L + W P ++ L ++Q
Sbjct: 516 NHSLGSLDSPP-TCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNL---QFQ 571
Query: 274 IRYRVEDS-VDWK---VVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSE 329
IRY + V WK V D S S + L VY VQVRC G WS
Sbjct: 572 IRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLC--AVYAVQVRCKRLD-----GLGYWSN 624
Query: 330 WSHP 333
WS+P
Sbjct: 625 WSNP 628
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/118 (27%), Positives = 58/118 (49%), Gaps = 10/118 (8%)
Query: 221 RSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVED 280
+S ++++ +++V DPP +H+ + L + W SPP + F +YQ++Y
Sbjct: 223 QSPLMSVQPINMVKPDPPLGLHMEITD--DGNLKISWSSPPLVP---FPLQYQVKYSENS 277
Query: 281 SVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAAST 338
+ + D + + TS + + PG+ Y VQVR GIWS+WS P +T
Sbjct: 278 TTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRL-----DGPGIWSDWSTPRVFTT 330
>gi|40254464 leptin receptor isoform 1 [Homo sapiens]
Length = 1165
Score = 55.8 bits (133), Expect = 7e-08
Identities = 72/304 (23%), Positives = 121/304 (39%), Gaps = 41/304 (13%)
Query: 52 IGSSLLATCSVHGDPPGATAEGLYWTLN-GRRLPPELSRVLNASTLALALANLNGSRQRS 110
+GS++ C + ++ + W +N ++P V++ + NLN ++ R
Sbjct: 344 VGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRG 403
Query: 111 G---DNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKN-MKDLTCRWTPGAHGETFLH 166
D + C + LYV + +NISC + + +TCRW+ +
Sbjct: 404 KFTYDAVYCCNEHECHHRYAELYV---IDVNINISCETDGYLTKMTCRWSTST-----IQ 455
Query: 167 TNYSLKYKLRWYGQDNTCEEYHTVGPHS----CHIPKD---------LALFTPYEIWVEA 213
+ +LR++ C + ++ P S C++ D + L + Y +W+
Sbjct: 456 SLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRI 515
Query: 214 TNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQ 273
+ LGS S T + D V PP + + L + W P ++ L ++Q
Sbjct: 516 NHSLGSLDSPP-TCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNL---QFQ 571
Query: 274 IRYRVEDS-VDWK---VVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSE 329
IRY + V WK V D S S + L VY VQVRC G WS
Sbjct: 572 IRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLC--AVYAVQVRCKRLD-----GLGYWSN 624
Query: 330 WSHP 333
WS+P
Sbjct: 625 WSNP 628
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/118 (27%), Positives = 58/118 (49%), Gaps = 10/118 (8%)
Query: 221 RSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVED 280
+S ++++ +++V DPP +H+ + L + W SPP + F +YQ++Y
Sbjct: 223 QSPLMSVQPINMVKPDPPLGLHMEITD--DGNLKISWSSPPLVP---FPLQYQVKYSENS 277
Query: 281 SVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAAST 338
+ + D + + TS + + PG+ Y VQVR GIWS+WS P +T
Sbjct: 278 TTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRL-----DGPGIWSDWSTPRVFTT 330
>gi|4503591 erythropoietin receptor precursor [Homo sapiens]
Length = 508
Score = 54.3 bits (129), Expect = 2e-07
Identities = 58/221 (26%), Positives = 89/221 (40%), Gaps = 31/221 (14%)
Query: 138 PVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYKLR---WYGQDNTCEEYHTVGPHS 194
P + C+++ ++DL C W A NYS Y+L W C +
Sbjct: 47 PEELLCFTERLEDLVCFWEEAASAGVG-PGNYSFSYQLEDEPW----KLCRLHQAPTARG 101
Query: 195 -----CHIPK-DLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGG 248
C +P D + F P E+ V A + G+ R + + I +VV D P + V+R+
Sbjct: 102 AVRFWCSLPTADTSSFVPLELRVTAAS--GAPRYHRV-IHINEVVLLDAPVGL-VARLAD 157
Query: 249 LEDQLSVRWVSPPALKDFLFQAKYQIRYRVEDSV-----DWKVVDDVSNQTSCRLAGLKP 303
+ +RW+ PP IRY V+ S + V+ + +T C L+ L+
Sbjct: 158 ESGHVVLRWLPPPETP-----MTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRG 212
Query: 304 GTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTPRSERP 344
T Y VR + G WS WS P + TP P
Sbjct: 213 RTRYTFAVRAR---MAEPSFGGFWSAWSEPVSLLTPSDLDP 250
>gi|4504647 interleukin 13 receptor, alpha 1 precursor [Homo
sapiens]
Length = 427
Score = 52.8 bits (125), Expect = 6e-07
Identities = 79/346 (22%), Positives = 129/346 (37%), Gaps = 45/346 (13%)
Query: 24 LLLCVLGAPRAGSGAHTAVISPQDPTLLIGSSLLATCSV---HGDPPGATAEGLYWTLN- 79
LLLC G G G A Q P + S+ C+V P GA++ W +
Sbjct: 13 LLLCAGGG---GGGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSH 69
Query: 80 -----GRRLPPELSRVLNASTLALALANLNGSRQRSGDNLVCHARDGSILAGSCLYV--G 132
+++ PE R + L + GS+ + ++ SIL C+ G
Sbjct: 70 FGDKQDKKIAPETRRSIEVP-LNERICLQVGSQCSTNES-----EKPSILVEKCISPPEG 123
Query: 133 LPPEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGP 192
P + C N+ + C W PG + T TNY+L Y R + + CE G
Sbjct: 124 DPESAVTELQCIWHNLSYMKCSWLPGRN--TSPDTNYTLYYWHRSLEKIHQCENIFREGQ 181
Query: 193 H-SCHIP----KDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVG 247
+ C KD + F + + + + G + + + V DPP H+ +
Sbjct: 182 YFGCSFDLTKVKD-SSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPP---HIKNLS 237
Query: 248 GLEDQLSVRWVSPP-ALKDFLF---------QAKYQIRYRVEDSVDWKVVDDVSNQTSC- 296
D L V+W +P + LF + + Y E + + TSC
Sbjct: 238 FHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNVENTSCF 297
Query: 297 RLAGLKPGTVYFVQVRCNPFGI-YGSKKAGIWSEWSHPTAASTPRS 341
+ G+ P T+ V++R + Y K +WS WS + R+
Sbjct: 298 MVPGVLPDTLNTVRIRVKTNKLCYEDDK--LWSNWSQEMSIGKKRN 341
>gi|14577917 Epstein-Barr virus induced 3 precursor [Homo sapiens]
Length = 229
Score = 52.4 bits (124), Expect = 8e-07
Identities = 59/193 (30%), Positives = 83/193 (43%), Gaps = 22/193 (11%)
Query: 153 CRWT----PGAHGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFT--P 206
C WT P + Y L R G C + T SC I D+ LF+ P
Sbjct: 46 CSWTLPPAPNSTSPVSFIATYRLGMAAR--GHSWPCLQ-QTPTSTSCTIT-DVQLFSMAP 101
Query: 207 YEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDF 266
Y + V A + GS+ S V + ++ DPP V +S + E QL V+W PP F
Sbjct: 102 YVLNVTAVHPWGSSSSFVPFITE-HIIKPDPPEGVRLSPLA--ERQLQVQW-EPPGSWPF 157
Query: 267 --LFQAKYQIRYRVEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKA 324
+F KY IRY+ + + + V + TS L ++P Y+VQV YG
Sbjct: 158 PEIFSLKYWIRYKRQGAARFHRVGPIE-ATSFILRAVRPRARYYVQVAAQDLTDYGE--- 213
Query: 325 GIWSEWSHPTAAS 337
S+WS P A+
Sbjct: 214 --LSDWSLPATAT 224
>gi|10834992 interleukin 13 receptor, alpha 2 precursor [Homo
sapiens]
Length = 380
Score = 50.1 bits (118), Expect = 4e-06
Identities = 59/209 (28%), Positives = 90/209 (43%), Gaps = 25/209 (11%)
Query: 132 GLPPEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYKLRWY-GQDNT--CEEYH 188
G+P K ++ C N + L C W PG L TNY+L Y WY G D+ C +Y
Sbjct: 134 GIPETKVQDMDCVYYNWQYLLCSWKPGI--GVLLDTNYNLFY---WYEGLDHALQCVDYI 188
Query: 189 TVGPHS--CHIP-KDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSR 245
+ C P + + + + I V ++ RS T + ++V PP + +R
Sbjct: 189 KADGQNIGCRFPYLEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLPPVYLTFTR 248
Query: 246 VGGLEDQLSVRW---VSPPALKDFLFQAKYQIRYRVEDSVDWKVVDDVSNQTSCRLAGLK 302
E + ++W + P + F Y+I R +D+ V V N+T +
Sbjct: 249 ESSCE--IKLKWSIPLGPIPARCF----DYEIEIREDDTT--LVTATVENETYTLKTTNE 300
Query: 303 PGTVYFVQVRCNPFGIYGSKKAGIWSEWS 331
+ FV VR + IY S GIWSEWS
Sbjct: 301 TRQLCFV-VR-SKVNIYCSDD-GIWSEWS 326
>gi|5031785 interleukin 12 receptor, beta 1 isoform 1 precursor
[Homo sapiens]
Length = 662
Score = 49.7 bits (117), Expect = 5e-06
Identities = 41/139 (29%), Positives = 62/139 (44%), Gaps = 15/139 (10%)
Query: 209 IWVEATNRLGSARSDVLTLDILDVVTTDPP-PDVHVSRVGGLEDQLSVRWVSPPALKDFL 267
+WVE+ R + +S +TL + + V +PP D+ VS++ G QL + W +P D
Sbjct: 113 LWVESWARNQTEKSPEVTLQLYNSVKYEPPLGDIKVSKLAG---QLRMEWETP----DNQ 165
Query: 268 FQAKYQIRYRVEDSVDWKVVD--DVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAG 325
A+ Q R+R S WK+ D + T L L+ Q+R G GS
Sbjct: 166 VGAEVQFRHRTPSS-PWKLGDCGPQDDDTESCLCPLEMNVAQEFQLRRRQLGSQGSS--- 221
Query: 326 IWSEWSHPTAASTPRSERP 344
WS+WS P +P
Sbjct: 222 -WSKWSSPVCVPPENPPQP 239
Score = 34.3 bits (77), Expect = 0.22
Identities = 29/94 (30%), Positives = 39/94 (41%), Gaps = 17/94 (18%)
Query: 242 HVSRVGGLEDQLSVRWVS------PPALKDFLFQAKYQIRYRVEDSVDWKVVDDVSNQTS 295
HVS D +SV W P LK+ Y +R R EDS +T
Sbjct: 451 HVSVKNHSLDSVSVDWAPSLLSTCPGVLKE------YVVRCRDEDSKQVSEHPVQPTETQ 504
Query: 296 CRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSE 329
L+GL+ G Y VQVR + + G+WS+
Sbjct: 505 VTLSGLRAGVAYTVQVRADTAWL-----RGVWSQ 533
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.442
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,107,017
Number of Sequences: 37866
Number of extensions: 1094303
Number of successful extensions: 4459
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 174
Number of HSP's that attempted gapping in prelim test: 4103
Number of HSP's gapped (non-prelim): 484
length of query: 422
length of database: 18,247,518
effective HSP length: 105
effective length of query: 317
effective length of database: 14,271,588
effective search space: 4524093396
effective search space used: 4524093396
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.