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Search of human proteins with 47132591
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
(948 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 1884 0.0
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 1860 0.0
gi|5453974 protein kinase N2 [Homo sapiens] 1078 0.0
gi|40254851 protein kinase PKNbeta [Homo sapiens] 867 0.0
gi|28557781 protein kinase C, eta [Homo sapiens] 328 2e-89
gi|4885563 protein kinase C, epsilon [Homo sapiens] 324 3e-88
gi|4506067 protein kinase C, alpha [Homo sapiens] 322 1e-87
gi|5453976 protein kinase C, theta [Homo sapiens] 321 2e-87
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 319 7e-87
gi|13384594 protein kinase C, gamma [Homo sapiens] 319 7e-87
gi|47157325 protein kinase C, delta [Homo sapiens] 318 2e-86
gi|31377782 protein kinase C, delta [Homo sapiens] 318 2e-86
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 316 7e-86
gi|4502023 AKT2 kinase [Homo sapiens] 314 3e-85
gi|62241015 AKT1 kinase [Homo sapiens] 310 3e-84
gi|62241013 AKT1 kinase [Homo sapiens] 310 3e-84
gi|62241011 AKT1 kinase [Homo sapiens] 310 3e-84
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 308 2e-83
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 308 2e-83
gi|133908623 protein kinase C, iota [Homo sapiens] 277 4e-74
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 270 5e-72
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 270 6e-72
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 270 6e-72
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 270 6e-72
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 269 8e-72
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 265 2e-70
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 264 3e-70
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 264 3e-70
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 260 4e-69
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 255 1e-67
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 1884 bits (4881), Expect = 0.0
Identities = 948/948 (100%), Positives = 948/948 (100%)
Query: 1 MAEANNPSEQELESEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKE 60
MAEANNPSEQELESEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKE
Sbjct: 1 MAEANNPSEQELESEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKE 60
Query: 61 GAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPG 120
GAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPG
Sbjct: 61 GAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPG 120
Query: 121 AGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSK 180
AGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSK
Sbjct: 121 AGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSK 180
Query: 181 TKIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKN 240
TKIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKN
Sbjct: 181 TKIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKN 240
Query: 241 VLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAA 300
VLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAA
Sbjct: 241 VLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAA 300
Query: 301 ASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTP 360
ASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTP
Sbjct: 301 ASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTP 360
Query: 361 DSRPPFLSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNA 420
DSRPPFLSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNA
Sbjct: 361 DSRPPFLSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNA 420
Query: 421 WDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEV 480
WDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEV
Sbjct: 421 WDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEV 480
Query: 481 TFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSP 540
TFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSP
Sbjct: 481 TFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSP 540
Query: 541 GASPGSEARTTGDISVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQ 600
GASPGSEARTTGDISVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQ
Sbjct: 541 GASPGSEARTTGDISVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQ 600
Query: 601 ETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVAR 660
ETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVAR
Sbjct: 601 ETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVAR 660
Query: 661 DEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSE 720
DEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSE
Sbjct: 661 DEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSE 720
Query: 721 PRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTST 780
PRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTST
Sbjct: 721 PRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTST 780
Query: 781 FCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRY 840
FCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRY
Sbjct: 781 FCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRY 840
Query: 841 PRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPT 900
PRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPT
Sbjct: 841 PRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPT 900
Query: 901 LSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC 948
LSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC
Sbjct: 901 LSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC 948
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 1860 bits (4819), Expect = 0.0
Identities = 935/937 (99%), Positives = 937/937 (100%)
Query: 12 LESEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTD 71
++SEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTD
Sbjct: 6 VQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTD 65
Query: 72 LGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNL 131
LGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNL
Sbjct: 66 LGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNL 125
Query: 132 SRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLR 191
SRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLR
Sbjct: 126 SRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLR 185
Query: 192 RALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAP 251
RALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAP
Sbjct: 186 RALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAP 245
Query: 252 DRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAAASSAAFSTRLA 311
DRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAAASSAAFSTRLA
Sbjct: 246 DRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAAASSAAFSTRLA 305
Query: 312 GPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTPDSRPPFLSRPA 371
GPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTPDSRPPFLSRPA
Sbjct: 306 GPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTPDSRPPFLSRPA 365
Query: 372 RGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAWDQSFTLELER 431
RGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAWDQSFTLELER
Sbjct: 366 RGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAWDQSFTLELER 425
Query: 432 ARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPVIERIP 491
ARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPVIERIP
Sbjct: 426 ARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPVIERIP 485
Query: 492 RLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSPGASPGSEARTT 551
RLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSPGASPGSEARTT
Sbjct: 486 RLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSPGASPGSEARTT 545
Query: 552 GDISVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPL 611
GDISVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPL
Sbjct: 546 GDISVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPL 605
Query: 612 RKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKR 671
RKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKR
Sbjct: 606 RKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKR 665
Query: 672 ILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVV 731
ILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVV
Sbjct: 666 ILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVV 725
Query: 732 LGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 791
LGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE
Sbjct: 726 LGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 785
Query: 792 VLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGI 851
VLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGI
Sbjct: 786 VLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGI 845
Query: 852 MRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFD 911
MRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFD
Sbjct: 846 MRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFD 905
Query: 912 EEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC 948
EEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC
Sbjct: 906 EEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC 942
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 1078 bits (2788), Expect = 0.0
Identities = 585/997 (58%), Positives = 720/997 (72%), Gaps = 66/997 (6%)
Query: 4 ANNPSE-----QELESEPRSWSLLEQLG-LAGADLAAPGVQQQLELERERLRREIRKELK 57
A+NP EL+ + RS E + + D + VQQ+L+ ++R++REIRKELK
Sbjct: 2 ASNPERGEILLTELQGDSRSLPFSENVSAVQKLDFSDTMVQQKLDDIKDRIKREIRKELK 61
Query: 58 LKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQ 117
+KEGAENLR+ TTD +SL V+ +L+ S+++L+ LH +LQEL+AH+V+ DP D P+
Sbjct: 62 IKEGAENLRKVTTDK-KSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPR 120
Query: 118 SPGA--GGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQM 175
+P P CS +N +R+ L+KQL IELKVKQGAENMIQ YSNGS+KDRKL TAQQ+
Sbjct: 121 TPDTPNNDPRCSTSN-NRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQL 179
Query: 176 LQDSKTKIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVA 235
LQDSKTKI++IRMQ+ +A+Q +L A P + +ELR+EELRHHFR+E AVA
Sbjct: 180 LQDSKTKIEVIRMQILQAVQTNELAFDNA------KPVISPLELRMEELRHHFRIEFAVA 233
Query: 236 EGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLR 295
EGAKNV++LL + K DRKA+SEAQ + ES+QKL LL+ +LE+RL E+P +HPK R++
Sbjct: 234 EGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIII 293
Query: 296 EELA-AASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPW-NPTPS 353
EEL+ A+S S R + YSTL KPA LTGTLEVR++GC+D+ E +P + S
Sbjct: 294 EELSLVAASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATS 353
Query: 354 MGGPG--TPDSRPPFLSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQT 411
+ PG ++R F+SR ++ S+SGS R+ LK + + +++V VLKLDNTVVGQT
Sbjct: 354 VALPGWSPSETRSSFMSRTSK---SKSGS--SRNLLKTD-DLSNDVCAVLKLDNTVVGQT 407
Query: 412 SWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDME 471
SWKP +WDQ FTLEL+R+RELE++V+WRD R LCA+KFL+LEDFLDN+RH + L +E
Sbjct: 408 SWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLE 467
Query: 472 PQGCLVAEVTFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPN 531
PQG L AEVTF NPVIER P+L+RQKKIFSKQQGK F RA QMNI++ATW RL+RR IP
Sbjct: 468 PQGTLFAEVTFFNPVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPT 527
Query: 532 ATGTGTFSPGASPGSE-----------ARTTGDISVEKLNLGTDSDSSP----------- 569
+GTFSP A + A D +V KL+ + + P
Sbjct: 528 VNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEI 587
Query: 570 QKSSR----DPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPL--------- 616
+SS D P S IQ LP E S L S +
Sbjct: 588 DESSELRVLDIPGQDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQ 647
Query: 617 -----TLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKR 671
L+DF+ AVLGRGHFGKVLL+E++ + E+FAIKALKKGDIVARDEV+SLMCEKR
Sbjct: 648 QRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKR 707
Query: 672 ILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVV 731
I V S HPFLVNLF CFQT EHVCFVMEY+AGGDLM+HIH+DVFSEPRA+FY+ACVV
Sbjct: 708 IFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVV 767
Query: 732 LGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 791
LGLQ+LHEHKIVYRDLKLDNLLLDTEG+VKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE
Sbjct: 768 LGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 827
Query: 792 VLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGI 851
VLT+TSYTRAVDWWGLGVL+YEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS EAI I
Sbjct: 828 VLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISI 887
Query: 852 MRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFD 911
MRRLLRRNPERRLG+SE+DAEDVKK PFFR + W AL+ +++ PPF+PT+ GR DVSNFD
Sbjct: 888 MRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFD 947
Query: 912 EEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC 948
+EFT EAP L+PPR+ R L+ EQ F DFD++A C
Sbjct: 948 DEFTSEAPILTPPREPRILSEEEQEMFRDFDYIADWC 984
>gi|40254851 protein kinase PKNbeta [Homo sapiens]
Length = 889
Score = 867 bits (2241), Expect = 0.0
Identities = 480/917 (52%), Positives = 608/917 (66%), Gaps = 63/917 (6%)
Query: 42 ELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELH 101
E E+E +RR I+KELK+KEG ENLRR TD R LG V+ LLR S+RRL+ LH +L+ELH
Sbjct: 17 EDEKEVIRRAIQKELKIKEGVENLRRVATDR-RHLGHVQQLLRSSNRRLEQLHGELRELH 75
Query: 102 AHVVLPDPAATHDGPQSPGAGGPTCSATNLS--RVAGLEKQLAIELKVKQGAENMIQTYS 159
A ++LP P GP P A GP A L + L +QL +ELKVKQGAENM T +
Sbjct: 76 ARILLPGPGP---GPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCA 132
Query: 160 NGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVEL 219
+G+ K+RKLL AQQML+DS+ K+ ++RM++ + GSP+ G EL
Sbjct: 133 SGTPKERKLLAAAQQMLRDSQLKVALLRMKISSL-------------EASGSPEPGP-EL 178
Query: 220 RIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALER 279
EEL+H VE AVAEGAKNV++LLS+ + DRKA++EAQ +L ES+QKL LLR ALE+
Sbjct: 179 LAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQ 238
Query: 280 RLGELPADHPKGRLLREELAAASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGC 339
L +LP HP + EL AA P P+ T KP LTGTL+VR++GC
Sbjct: 239 LLEQLPPAHPLRSRVTRELRAAVPGY-------PQPS---GTPVKPTALTGTLQVRLLGC 288
Query: 340 RDLPETIPW-NPTPSMGGPGTPDSRPPFLSRPARG-LYSRSGSLSGRSSLKAEAENTSEV 397
L +P +P ++ S P+ G L +++ GR L SEV
Sbjct: 289 EQLLTAVPGRSPAAALA------------SSPSEGWLRTKAKHQRGRGEL------ASEV 330
Query: 398 STVLKLDNTVVGQTSWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLED 457
VLK+DN VVGQT W +WDQ+F + LERARELE+ V WRD R LC + FL+LED
Sbjct: 331 LAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLED 390
Query: 458 FLDNERHEVQLDMEPQGCLVAEVTFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNID 517
FLDN H++ L + PQG L A+VTF +PVIER PRL+RQ++IFSK++G+ F RA QMN+
Sbjct: 391 FLDNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLG 450
Query: 518 VATWVRLLRRLIPNATGTGTFSPGAS---------PGSEARTTGDISVEKLNLGTDSDSS 568
+A W RL+ L+P + T SP S+ T + +K LG +
Sbjct: 451 MAAWGRLVMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPP 510
Query: 569 PQKSSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLG 628
P+ P P+S +P + P + T+ P P SP RK P L+DF+ LAVLG
Sbjct: 511 PKPPRLYLPQEPTSEETP--RTKRPHMEPRTRRGPSPP-ASPTRKPP-RLQDFRCLAVLG 566
Query: 629 RGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLF 688
RGHFGKVLL +F+ +G+ +AIKALKK ++++RDE+ESL CEKRIL AV GHPFL++L
Sbjct: 567 RGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLL 626
Query: 689 GCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLK 748
CFQT H CFV E+ GGDLM+ IH DVF EP+A FY ACVVLGLQFLHE KI+YRDLK
Sbjct: 627 ACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLK 686
Query: 749 LDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLG 808
LDNLLLD +G++KIADFGLCKEG+G+GDRTSTFCGTPEFLAPEVLT +YTRAVDWWGLG
Sbjct: 687 LDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLG 746
Query: 809 VLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSE 868
VLLYEMLVGE PFPGD EEEVFD IVN + YP FLS + + +++LL++ PE+RLG+ E
Sbjct: 747 VLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGE 806
Query: 869 RDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDAR 928
+DAE++K QPFFRT W+ALLAR + PPFVPTL G D+ F+ EFTG P L+PP
Sbjct: 807 QDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHS 866
Query: 929 PLTAAEQAAFLDFDFVA 945
LTA +QAAF DFDFV+
Sbjct: 867 LLTARQQAAFRDFDFVS 883
Score = 71.6 bits (174), Expect = 3e-12
Identities = 51/165 (30%), Positives = 81/165 (49%), Gaps = 24/165 (14%)
Query: 35 PGVQQQLELERERLRREIRKELKLKEGAENLRR----ATTDLGRSLGPVELLLRGSSRRL 90
P +Q E LRR++ ELK+K+GAEN+ T + L + +LR S ++
Sbjct: 97 PWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKV 156
Query: 91 DLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQG 150
LL ++ L A G P GP A L+ +L +E V +G
Sbjct: 157 ALLRMKISSLEA-----------SGSPEP---GPELLAEE------LQHRLHVEAAVAEG 196
Query: 151 AENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQ 195
A+N+++ S+ T+DRK L AQ LQ+S K+D++R+ L + L+
Sbjct: 197 AKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLE 241
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 328 bits (840), Expect = 2e-89
Identities = 173/372 (46%), Positives = 243/372 (65%), Gaps = 9/372 (2%)
Query: 577 PSSPSSLSSPIQESTAPELPSET-QETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKV 635
P + S S + ST E+ +E G + S R L +++F+F+ VLG+G FGKV
Sbjct: 313 PGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNR---LGIDNFEFIRVLGKGSFGKV 369
Query: 636 LLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPE 695
+L+ + +G+L+A+K LKK I+ D+VE M EKRIL+ + HPFL LF CFQTP+
Sbjct: 370 MLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN--HPFLTQLFCCFQTPD 427
Query: 696 HVCFVMEYSAGGDLMLHIH-SDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLL 754
+ FVME+ GGDLM HI S F E RA FY+A ++ L FLH+ I+YRDLKLDN+LL
Sbjct: 428 RLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLL 487
Query: 755 DTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEM 814
D EG+ K+ADFG+CKEG+ G T+TFCGTP+++APE+L + Y AVDWW +GVLLYEM
Sbjct: 488 DHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEM 547
Query: 815 LVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAED- 873
L G +PF ++E+++F++I+NDEV YP +L +A GI++ + +NP RLGS + E
Sbjct: 548 LCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHA 607
Query: 874 VKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAA 933
+ + PFF+ + W L R++ PPF P + R DVSNFD +F E P L+ P D L
Sbjct: 608 ILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT-PIDEGHLPMI 666
Query: 934 EQAAFLDFDFVA 945
Q F +F +V+
Sbjct: 667 NQDEFRNFSYVS 678
Score = 36.2 bits (82), Expect = 0.15
Identities = 34/135 (25%), Positives = 58/135 (42%), Gaps = 8/135 (5%)
Query: 384 RSSLKAEAENTSEVSTVLKLDNTVVGQTSWKP-CGPNAWDQSFTLELERARELELAVFWR 442
R SL + + + +D VGQTS K +++ F + LELAVF
Sbjct: 30 RHSLFKKGHQLLDPYLTVSVDQVRVGQTSTKQKTNKPTYNEEFCANVTDGGHLELAVFHE 89
Query: 443 DQRGL------CALKFLKLEDFLD-NERHEVQLDMEPQGCLVAEVTFRNPVIERIPRLRR 495
G C L+F +L ++ E +D+EP+G + +T E + R
Sbjct: 90 TPLGYDHFVANCTLQFQELLRTTGASDTFEGWVDLEPEGKVFVVITLTGSFTEATLQRDR 149
Query: 496 QKKIFSKQQGKAFQR 510
K F++++ +A +R
Sbjct: 150 IFKHFTRKRQRAMRR 164
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 324 bits (830), Expect = 3e-88
Identities = 165/377 (43%), Positives = 243/377 (64%), Gaps = 21/377 (5%)
Query: 565 SDSSPQKSSRDPPSSP-----SSLSSPIQESTAPELPSETQE---TPGPALCSPLRKSP- 615
S S + S+ P+SP L + I+++ + + E +P L SP
Sbjct: 336 SSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEV 395
Query: 616 -------LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMC 668
L L++F F+ VLG+G FGKV+L+E + E++A+K LKK I+ D+V+ M
Sbjct: 396 RQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMT 455
Query: 669 EKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIH-SDVFSEPRAIFYS 727
EKRILA HP+L L+ CFQT + + FVMEY GGDLM I S F EPR+ FY+
Sbjct: 456 EKRILALARK--HPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYA 513
Query: 728 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF 787
A V L FLH+H ++YRDLKLDN+LLD EG+ K+ADFG+CKEG+ G T+TFCGTP++
Sbjct: 514 AEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDY 573
Query: 788 LAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAE 847
+APE+L + Y +VDWW LGVL+YEM+ G+ PF D+E+++F+SI++D+V YP +LS E
Sbjct: 574 IAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKE 633
Query: 848 AIGIMRRLLRRNPERRLG--SSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRT 905
A+ I++ + +NP +RLG +S+ + +K+ PFF+ + W L +++ PPF P + +
Sbjct: 634 AVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKR 693
Query: 906 DVSNFDEEFTGEAPTLS 922
DV+NFD++FT E P L+
Sbjct: 694 DVNNFDQDFTREEPVLT 710
Score = 40.4 bits (93), Expect = 0.008
Identities = 37/128 (28%), Positives = 61/128 (47%), Gaps = 16/128 (12%)
Query: 401 LKLDNTVVGQTSWKP-CGPNAWDQSFTLELERARELELAVF------WRDQRGLCALKFL 453
L +D++ +GQT+ K AW F ++ R++ELAVF + D C ++F
Sbjct: 44 LNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQF- 102
Query: 454 KLEDFLDN-ERH-EVQLDMEPQGCLVAEVTFRNPVIE----RIPRLRRQKKIFSKQQGKA 507
E+ L N RH E +D+EP+G + + E R+ R++ K+QG
Sbjct: 103 --EELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAV 160
Query: 508 FQRARQMN 515
+R Q+N
Sbjct: 161 RRRVHQVN 168
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 322 bits (824), Expect = 1e-87
Identities = 166/350 (47%), Positives = 227/350 (64%), Gaps = 11/350 (3%)
Query: 596 PSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKG 655
PSE ++ P L + L DF FL VLG+G FGKV+L++ + + EL+AIK LKK
Sbjct: 320 PSEDRKQPSNNL------DRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKD 373
Query: 656 DIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS 715
++ D+VE M EKR+LA + PFL L CFQT + + FVMEY GGDLM HI
Sbjct: 374 VVIQDDDVECTMVEKRVLALLDKP--PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQ 431
Query: 716 -DVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGY 774
F EP+A+FY+A + +GL FLH+ I+YRDLKLDN++LD+EG++KIADFG+CKE M
Sbjct: 432 VGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMD 491
Query: 775 GDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIV 834
G T TFCGTP+++APE++ Y ++VDWW GVLLYEML G+ PF G+DE+E+F SI+
Sbjct: 492 GVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIM 551
Query: 835 NDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLP 894
V YP+ LS EA+ I + L+ ++P +RLG DV++ FFR + WE L R +
Sbjct: 552 EHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQ 611
Query: 895 PPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 944
PPF P + G+ NFD+ FT P L+PP D + +Q+ F F +V
Sbjct: 612 PPFKPKVCGK-GAENFDKFFTRGQPVLTPP-DQLVIANIDQSDFEGFSYV 659
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 321 bits (823), Expect = 2e-87
Identities = 178/381 (46%), Positives = 234/381 (61%), Gaps = 16/381 (4%)
Query: 569 PQKSSRDPPSSPSSLSSPIQE-STAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVL 627
P R+P S SP+ E LP P+L + L +EDF +L
Sbjct: 334 PTPGKREPQGI--SWESPLDEVDKMCHLPEPELNKERPSL-----QIKLKIEDFILHKML 386
Query: 628 GRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNL 687
G+G FGKV L+EF+ + + FAIKALKK ++ D+VE M EKR+L+ HPFL ++
Sbjct: 387 GKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWE--HPFLTHM 444
Query: 688 FGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFLHEHKIVYRD 746
F FQT E++ FVMEY GGDLM HI S F RA FY+A ++LGLQFLH IVYRD
Sbjct: 445 FCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRD 504
Query: 747 LKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWG 806
LKLDN+LLD +G++KIADFG+CKE M +T+TFCGTP+++APE+L Y +VDWW
Sbjct: 505 LKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWS 564
Query: 807 LGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGS 866
GVLLYEML+G+SPF G DEEE+F SI D YPR+L EA ++ +L R PE+RLG
Sbjct: 565 FGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGV 624
Query: 867 SERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRD 926
D+++ P FR + WE L + + PPF P + D SNFD+EF E P LS D
Sbjct: 625 ----RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLS-FAD 679
Query: 927 ARPLTAAEQAAFLDFDFVAGG 947
+ + +Q F +F F+ G
Sbjct: 680 RALINSMDQNMFRNFSFMNPG 700
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 319 bits (818), Expect = 7e-87
Identities = 159/330 (48%), Positives = 216/330 (65%), Gaps = 5/330 (1%)
Query: 616 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 675
+ L DF FL VLG+G FGKV+LSE + + EL+A+K LKK ++ D+VE M EKR+LA
Sbjct: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396
Query: 676 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGL 734
PFL L CFQT + + FVMEY GGDLM HI F EP A+FY+A + +GL
Sbjct: 397 PGKP--PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454
Query: 735 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 794
FL I+YRDLKLDN++LD+EG++KIADFG+CKE + G T TFCGTP+++APE++
Sbjct: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514
Query: 795 DTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR 854
Y ++VDWW GVLLYEML G++PF G+DE+E+F SI+ V YP+ +S EA+ I +
Sbjct: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574
Query: 855 LLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEF 914
L+ ++P +RLG D+K+ FFR + WE L + + PP+ P GR + NFD F
Sbjct: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRFF 633
Query: 915 TGEAPTLSPPRDARPLTAAEQAAFLDFDFV 944
T P L+PP D + +Q+ F F FV
Sbjct: 634 TRHPPVLTPP-DQEVIRNIDQSEFEGFSFV 662
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 319 bits (818), Expect = 7e-87
Identities = 175/363 (48%), Positives = 228/363 (62%), Gaps = 14/363 (3%)
Query: 590 STAPELPSETQETPGPALC----SPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGE 645
S++P +PS + P C SP R L + DF FL VLG+G FGKV+L+E R S E
Sbjct: 320 SSSP-IPSPSPSPTDPKRCFFGASPGR---LHISDFSFLMVLGKGSFGKVMLAERRGSDE 375
Query: 646 LFAIKALKKGDIVARDEVESLMCEKRILA--AVTSAGHP-FLVNLFGCFQTPEHVCFVME 702
L+AIK LKK IV D+V+ + EKR+LA G P FL L FQTP+ + FVME
Sbjct: 376 LYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVME 435
Query: 703 YSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVK 761
Y GGDLM HI F EP A FY+A + +GL FLH I+YRDLKLDN++LD EG++K
Sbjct: 436 YVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIK 495
Query: 762 IADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPF 821
I DFG+CKE + G T TFCGTP+++APE++ Y ++VDWW GVLLYEML G+ PF
Sbjct: 496 ITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPF 555
Query: 822 PGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFR 881
G+DEEE+F +I+ V YP+ LS EA+ I + L ++P +RLGS ++ FFR
Sbjct: 556 DGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFR 615
Query: 882 TLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDF 941
+ WE L +PPPF P GR+ NFD+ FT AP L+PP D L + +QA F F
Sbjct: 616 WIDWERLERLEIPPPFRPRPCGRSG-ENFDKFFTRAAPALTPP-DRLVLASIDQADFQGF 673
Query: 942 DFV 944
+V
Sbjct: 674 TYV 676
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 318 bits (815), Expect = 2e-86
Identities = 167/332 (50%), Positives = 219/332 (65%), Gaps = 8/332 (2%)
Query: 614 SPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRIL 673
S + +F F VLG+G FGKVLL E + GE FAIKALKK ++ D+VE M EKR+L
Sbjct: 342 SKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVL 401
Query: 674 AAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDV-FSEPRAIFYSACVVL 732
+A +PFL +L FQT +H+ FVME+ GGDLM HI F RA FY+A ++
Sbjct: 402 TL--AAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMC 459
Query: 733 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 792
GLQFLH I+YRDLKLDN+LLD +G++KIADFG+CKE + R STFCGTP+++APE+
Sbjct: 460 GLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEI 519
Query: 793 LTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIM 852
L YT +VDWW GVLLYEML+G+SPF GDDE+E+F+SI D YPR+++ E+ I+
Sbjct: 520 LQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIL 579
Query: 853 RRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDE 912
+L R P +RLG + ++K PFF+T+ W L RRL PPF P + D SNFD+
Sbjct: 580 EKLFEREPTKRLGVT----GNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQ 635
Query: 913 EFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 944
EF E LS D + + +Q+AF F FV
Sbjct: 636 EFLNEKARLS-YSDKNLIDSMDQSAFAGFSFV 666
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 318 bits (815), Expect = 2e-86
Identities = 167/332 (50%), Positives = 219/332 (65%), Gaps = 8/332 (2%)
Query: 614 SPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRIL 673
S + +F F VLG+G FGKVLL E + GE FAIKALKK ++ D+VE M EKR+L
Sbjct: 342 SKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVL 401
Query: 674 AAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDV-FSEPRAIFYSACVVL 732
+A +PFL +L FQT +H+ FVME+ GGDLM HI F RA FY+A ++
Sbjct: 402 TL--AAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMC 459
Query: 733 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 792
GLQFLH I+YRDLKLDN+LLD +G++KIADFG+CKE + R STFCGTP+++APE+
Sbjct: 460 GLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEI 519
Query: 793 LTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIM 852
L YT +VDWW GVLLYEML+G+SPF GDDE+E+F+SI D YPR+++ E+ I+
Sbjct: 520 LQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIL 579
Query: 853 RRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDE 912
+L R P +RLG + ++K PFF+T+ W L RRL PPF P + D SNFD+
Sbjct: 580 EKLFEREPTKRLGVT----GNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQ 635
Query: 913 EFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 944
EF E LS D + + +Q+AF F FV
Sbjct: 636 EFLNEKARLS-YSDKNLIDSMDQSAFAGFSFV 666
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 316 bits (809), Expect = 7e-86
Identities = 156/329 (47%), Positives = 214/329 (65%), Gaps = 4/329 (1%)
Query: 616 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 675
+ L DF FL VLG+G FGKV+LSE + + EL+A+K LKK ++ D+VE M EKR+LA
Sbjct: 337 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396
Query: 676 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGL 734
PFL L CFQT + + FVMEY GGDLM HI F EP A+FY+A + +GL
Sbjct: 397 PGKP--PFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGL 454
Query: 735 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 794
FL I+YRDLKLDN++LD+EG++KIADFG+CKE + G T TFCGTP+++APE++
Sbjct: 455 FFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA 514
Query: 795 DTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRR 854
Y ++VDWW GVLLYEML G++PF G+DE+E+F SI+ V YP+ +S EA+ I +
Sbjct: 515 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 574
Query: 855 LLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEF 914
L+ ++P +RLG D+K+ FFR + WE L + + PP+ P + D SNFD+EF
Sbjct: 575 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEF 634
Query: 915 TGEAPTLSPPRDARPLTAAEQAAFLDFDF 943
T + P P D + +Q F F +
Sbjct: 635 TRQ-PVELTPTDKLFIMNLDQNEFAGFSY 662
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 314 bits (804), Expect = 3e-85
Identities = 149/330 (45%), Positives = 222/330 (67%), Gaps = 4/330 (1%)
Query: 596 PSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKG 655
PS++ T + ++ +T+ DF +L +LG+G FGKV+L + +G +A+K L+K
Sbjct: 127 PSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKE 186
Query: 656 DIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS 715
I+A+DEV + E R+L + HPFL L FQT + +CFVMEY+ GG+L H+
Sbjct: 187 VIIAKDEVAHTVTESRVLQ---NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR 243
Query: 716 D-VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGY 774
+ VF+E RA FY A +V L++LH +VYRD+KL+NL+LD +G++KI DFGLCKEG+
Sbjct: 244 ERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD 303
Query: 775 GDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIV 834
G TFCGTPE+LAPEVL D Y RAVDWWGLGV++YEM+ G PF D E +F+ I+
Sbjct: 304 GATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL 363
Query: 835 NDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLP 894
+E+R+PR LS EA ++ LL+++P++RLG DA++V + FF ++ W+ ++ ++L
Sbjct: 364 MEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLL 423
Query: 895 PPFVPTLSGRTDVSNFDEEFTGEAPTLSPP 924
PPF P ++ D FD+EFT ++ T++PP
Sbjct: 424 PPFKPQVTSEVDTRYFDDEFTAQSITITPP 453
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 310 bits (795), Expect = 3e-84
Identities = 151/314 (48%), Positives = 216/314 (68%), Gaps = 5/314 (1%)
Query: 613 KSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRI 672
K +T+ +F++L +LG+G FGKV+L + + +G +A+K LKK IVA+DEV + E R+
Sbjct: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
Query: 673 LAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVV 731
L ++ HPFL L FQT + +CFVMEY+ GG+L H+ + VFSE RA FY A +V
Sbjct: 202 LQ---NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
Query: 732 LGLQFLHEHK-IVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 790
L +LH K +VYRDLKL+NL+LD +G++KI DFGLCKEG+ G TFCGTPE+LAP
Sbjct: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318
Query: 791 EVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIG 850
EVL D Y RAVDWWGLGV++YEM+ G PF D E++F+ I+ +E+R+PR L EA
Sbjct: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKS 378
Query: 851 IMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNF 910
++ LL+++P++RLG DA+++ + FF + W+ + ++L PPF P ++ TD F
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF 438
Query: 911 DEEFTGEAPTLSPP 924
DEEFT + T++PP
Sbjct: 439 DEEFTAQMITITPP 452
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 310 bits (795), Expect = 3e-84
Identities = 151/314 (48%), Positives = 216/314 (68%), Gaps = 5/314 (1%)
Query: 613 KSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRI 672
K +T+ +F++L +LG+G FGKV+L + + +G +A+K LKK IVA+DEV + E R+
Sbjct: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
Query: 673 LAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVV 731
L ++ HPFL L FQT + +CFVMEY+ GG+L H+ + VFSE RA FY A +V
Sbjct: 202 LQ---NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
Query: 732 LGLQFLHEHK-IVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 790
L +LH K +VYRDLKL+NL+LD +G++KI DFGLCKEG+ G TFCGTPE+LAP
Sbjct: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318
Query: 791 EVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIG 850
EVL D Y RAVDWWGLGV++YEM+ G PF D E++F+ I+ +E+R+PR L EA
Sbjct: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKS 378
Query: 851 IMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNF 910
++ LL+++P++RLG DA+++ + FF + W+ + ++L PPF P ++ TD F
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF 438
Query: 911 DEEFTGEAPTLSPP 924
DEEFT + T++PP
Sbjct: 439 DEEFTAQMITITPP 452
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 310 bits (795), Expect = 3e-84
Identities = 151/314 (48%), Positives = 216/314 (68%), Gaps = 5/314 (1%)
Query: 613 KSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRI 672
K +T+ +F++L +LG+G FGKV+L + + +G +A+K LKK IVA+DEV + E R+
Sbjct: 142 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 201
Query: 673 LAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVV 731
L ++ HPFL L FQT + +CFVMEY+ GG+L H+ + VFSE RA FY A +V
Sbjct: 202 LQ---NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 258
Query: 732 LGLQFLHEHK-IVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 790
L +LH K +VYRDLKL+NL+LD +G++KI DFGLCKEG+ G TFCGTPE+LAP
Sbjct: 259 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 318
Query: 791 EVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIG 850
EVL D Y RAVDWWGLGV++YEM+ G PF D E++F+ I+ +E+R+PR L EA
Sbjct: 319 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKS 378
Query: 851 IMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNF 910
++ LL+++P++RLG DA+++ + FF + W+ + ++L PPF P ++ TD F
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF 438
Query: 911 DEEFTGEAPTLSPP 924
DEEFT + T++PP
Sbjct: 439 DEEFTAQMITITPP 452
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 308 bits (789), Expect = 2e-83
Identities = 148/309 (47%), Positives = 210/309 (67%), Gaps = 4/309 (1%)
Query: 617 TLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAV 676
T+ DF +L +LG+G FGKV+L + SG+ +A+K LKK I+A+DEV + E R+L
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK-- 201
Query: 677 TSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGLQ 735
+ HPFL +L FQT + +CFVMEY GG+L H+ + VFSE R FY A +V L
Sbjct: 202 -NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260
Query: 736 FLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTD 795
+LH KIVYRDLKL+NL+LD +G++KI DFGLCKEG+ TFCGTPE+LAPEVL D
Sbjct: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLED 320
Query: 796 TSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRL 855
Y RAVDWWGLGV++YEM+ G PF D E++F+ I+ +++++PR LS++A ++ L
Sbjct: 321 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGL 380
Query: 856 LRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFT 915
L ++P +RLG DA+++ + FF + W+ + ++L PPF P ++ TD FDEEFT
Sbjct: 381 LIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFT 440
Query: 916 GEAPTLSPP 924
+ T++PP
Sbjct: 441 AQTITITPP 449
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 308 bits (789), Expect = 2e-83
Identities = 148/309 (47%), Positives = 210/309 (67%), Gaps = 4/309 (1%)
Query: 617 TLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAV 676
T+ DF +L +LG+G FGKV+L + SG+ +A+K LKK I+A+DEV + E R+L
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLK-- 201
Query: 677 TSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGLQ 735
+ HPFL +L FQT + +CFVMEY GG+L H+ + VFSE R FY A +V L
Sbjct: 202 -NTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260
Query: 736 FLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTD 795
+LH KIVYRDLKL+NL+LD +G++KI DFGLCKEG+ TFCGTPE+LAPEVL D
Sbjct: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLED 320
Query: 796 TSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRL 855
Y RAVDWWGLGV++YEM+ G PF D E++F+ I+ +++++PR LS++A ++ L
Sbjct: 321 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGL 380
Query: 856 LRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFT 915
L ++P +RLG DA+++ + FF + W+ + ++L PPF P ++ TD FDEEFT
Sbjct: 381 LIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFT 440
Query: 916 GEAPTLSPP 924
+ T++PP
Sbjct: 441 AQTITITPP 449
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 277 bits (708), Expect = 4e-74
Identities = 150/379 (39%), Positives = 223/379 (58%), Gaps = 25/379 (6%)
Query: 577 PSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVL 636
PSS SL +E A T+E+ G A S L L+DF L V+GRG + KVL
Sbjct: 221 PSSHESLDQVGEEKEA----MNTRES-GKA------SSSLGLQDFDLLRVIGRGSYAKVL 269
Query: 637 LSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEH 696
L + + ++A+K +KK + ++++ + EK + ++ HPFLV L CFQT
Sbjct: 270 LVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN--HPFLVGLHSCFQTESR 327
Query: 697 VCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLD 755
+ FV+EY GGDLM H+ E A FYSA + L L +LHE I+YRDLKLDN+LLD
Sbjct: 328 LFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLD 387
Query: 756 TEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEML 815
+EG++K+ D+G+CKEG+ GD TSTFCGTP ++APE+L Y +VDWW LGVL++EM+
Sbjct: 388 SEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMM 447
Query: 816 VGESPF---------PGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGS 866
G SPF + E+ +F I+ ++R PR LS +A +++ L ++P+ RLG
Sbjct: 448 AGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGC 507
Query: 867 SERDA-EDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPR 925
+ D++ PFFR + W+ + +++ PPF P +SG + NFD +FT E P P
Sbjct: 508 HPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNE-PVQLTPD 566
Query: 926 DARPLTAAEQAAFLDFDFV 944
D + +Q+ F F+++
Sbjct: 567 DDDIVRKIDQSEFEGFEYI 585
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 270 bits (690), Expect = 5e-72
Identities = 156/394 (39%), Positives = 225/394 (57%), Gaps = 26/394 (6%)
Query: 569 PQKSSRDPPSSP-SSLSSPIQESTAPELP-------SETQETPGPALC--------SPLR 612
P DPP+ S L P+ PELP S TP P P
Sbjct: 31 PWMGGADPPTPTLSCLLLPVP----PELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSA 86
Query: 613 KSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRI 672
DF FL V+G+G++GKVLL++ + G +A+K L+K I+ + E +M E+ +
Sbjct: 87 NPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSV 146
Query: 673 LAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDV-FSEPRAIFYSACVV 731
L + + HPFLV L FQTPE + FV++Y GG+L H+ + F EPRA FY+A V
Sbjct: 147 L--LKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVA 204
Query: 732 LGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 791
+ +LH I+YRDLK +N+LLD +G+V + DFGLCKEG+ D TSTFCGTPE+LAPE
Sbjct: 205 SAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPE 264
Query: 792 VLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGI 851
VL Y RAVDWW LG +LYEML G PF D +++++I++ ++ P + A +
Sbjct: 265 VLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDL 324
Query: 852 MRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFD 911
++ LL ++ +RLG S+ D ++K FF + W+ L +RL PPF P ++G D+ +FD
Sbjct: 325 LQSLLHKDQRQRLG-SKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFD 383
Query: 912 EEFTGEA--PTLSPPRDARPLTAAEQAAFLDFDF 943
EFT EA ++ D ++ +AFL F +
Sbjct: 384 PEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 417
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 270 bits (689), Expect = 6e-72
Identities = 135/338 (39%), Positives = 206/338 (60%), Gaps = 12/338 (3%)
Query: 616 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 675
L L+DF + V+GRG + KVLL + + +++A+K +KK + ++++ + EK +
Sbjct: 64 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123
Query: 676 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGL 734
+S +PFLV L CFQT + V+EY GGDLM H+ E A FY+A + + L
Sbjct: 124 ASS--NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIAL 181
Query: 735 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 794
FLHE I+YRDLKLDN+LLD +G++K+ D+G+CKEG+G GD TSTFCGTP ++APE+L
Sbjct: 182 NFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILR 241
Query: 795 DTSYTRAVDWWGLGVLLYEMLVGESPF-------PGDDEEEVFDSIVNDEVRYPRFLSAE 847
Y +VDWW LGVL++EM+ G SPF + E+ +F I+ +R PRFLS +
Sbjct: 242 GEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVK 301
Query: 848 AIGIMRRLLRRNPERRLGSSERDA-EDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTD 906
A +++ L ++P+ RLG + D+K FFR++ W+ L ++ PPF P ++
Sbjct: 302 ASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYG 361
Query: 907 VSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 944
+ NFD +FT E P P D + +Q+ F F+++
Sbjct: 362 LDNFDTQFTSE-PVQLTPDDEDAIKRIDQSEFEGFEYI 398
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 270 bits (689), Expect = 6e-72
Identities = 135/338 (39%), Positives = 206/338 (60%), Gaps = 12/338 (3%)
Query: 616 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 675
L L+DF + V+GRG + KVLL + + +++A+K +KK + ++++ + EK +
Sbjct: 64 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123
Query: 676 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGL 734
+S +PFLV L CFQT + V+EY GGDLM H+ E A FY+A + + L
Sbjct: 124 ASS--NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIAL 181
Query: 735 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 794
FLHE I+YRDLKLDN+LLD +G++K+ D+G+CKEG+G GD TSTFCGTP ++APE+L
Sbjct: 182 NFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILR 241
Query: 795 DTSYTRAVDWWGLGVLLYEMLVGESPF-------PGDDEEEVFDSIVNDEVRYPRFLSAE 847
Y +VDWW LGVL++EM+ G SPF + E+ +F I+ +R PRFLS +
Sbjct: 242 GEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVK 301
Query: 848 AIGIMRRLLRRNPERRLGSSERDA-EDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTD 906
A +++ L ++P+ RLG + D+K FFR++ W+ L ++ PPF P ++
Sbjct: 302 ASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYG 361
Query: 907 VSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 944
+ NFD +FT E P P D + +Q+ F F+++
Sbjct: 362 LDNFDTQFTSE-PVQLTPDDEDAIKRIDQSEFEGFEYI 398
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 270 bits (689), Expect = 6e-72
Identities = 135/338 (39%), Positives = 206/338 (60%), Gaps = 12/338 (3%)
Query: 616 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 675
L L+DF + V+GRG + KVLL + + +++A+K +KK + ++++ + EK +
Sbjct: 247 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 306
Query: 676 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGL 734
+S +PFLV L CFQT + V+EY GGDLM H+ E A FY+A + + L
Sbjct: 307 ASS--NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIAL 364
Query: 735 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 794
FLHE I+YRDLKLDN+LLD +G++K+ D+G+CKEG+G GD TSTFCGTP ++APE+L
Sbjct: 365 NFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILR 424
Query: 795 DTSYTRAVDWWGLGVLLYEMLVGESPF-------PGDDEEEVFDSIVNDEVRYPRFLSAE 847
Y +VDWW LGVL++EM+ G SPF + E+ +F I+ +R PRFLS +
Sbjct: 425 GEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVK 484
Query: 848 AIGIMRRLLRRNPERRLGSSERDA-EDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTD 906
A +++ L ++P+ RLG + D+K FFR++ W+ L ++ PPF P ++
Sbjct: 485 ASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYG 544
Query: 907 VSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 944
+ NFD +FT E P P D + +Q+ F F+++
Sbjct: 545 LDNFDTQFTSE-PVQLTPDDEDAIKRIDQSEFEGFEYI 581
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 269 bits (688), Expect = 8e-72
Identities = 140/327 (42%), Positives = 207/327 (63%), Gaps = 6/327 (1%)
Query: 620 DFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSA 679
DF FL V+G+G++GKVLL++ + G +A+K L+K I+ + E +M E+ +L + +
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVL--LKNV 91
Query: 680 GHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDV-FSEPRAIFYSACVVLGLQFLH 738
HPFLV L FQTPE + FV++Y GG+L H+ + F EPRA FY+A V + +LH
Sbjct: 92 RHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLH 151
Query: 739 EHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSY 798
I+YRDLK +N+LLD +G+V + DFGLCKEG+ D TSTFCGTPE+LAPEVL Y
Sbjct: 152 SLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPY 211
Query: 799 TRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRR 858
RAVDWW LG +LYEML G PF D +++++I++ ++ P + A +++ LL +
Sbjct: 212 DRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHK 271
Query: 859 NPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEA 918
+ +RLG S+ D ++K FF + W+ L +RL PPF P ++G D+ +FD EFT EA
Sbjct: 272 DQRQRLG-SKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEA 330
Query: 919 --PTLSPPRDARPLTAAEQAAFLDFDF 943
++ D ++ +AFL F +
Sbjct: 331 VSKSIGCTPDTVASSSGASSAFLGFSY 357
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 265 bits (677), Expect = 2e-70
Identities = 147/355 (41%), Positives = 212/355 (59%), Gaps = 20/355 (5%)
Query: 597 SETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEF---RPSGELFAIKALK 653
SET GP P E F+ L VLG+G +GKV +G++FA+K LK
Sbjct: 75 SETSVNRGPEKIRP--------ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLK 126
Query: 654 KGDIV--ARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLML 711
K IV A+D + E+ IL V HPF+V+L FQT + ++EY +GG+L +
Sbjct: 127 KAMIVRNAKDTAHT-KAERNILEEVK---HPFIVDLIYAFQTGGKLYLILEYLSGGELFM 182
Query: 712 HIHSD-VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKE 770
+ + +F E A FY A + + L LH+ I+YRDLK +N++L+ +G+VK+ DFGLCKE
Sbjct: 183 QLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKE 242
Query: 771 GMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVF 830
+ G T TFCGT E++APE+L + + RAVDWW LG L+Y+ML G PF G++ ++
Sbjct: 243 SIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTI 302
Query: 831 DSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLA 890
D I+ ++ P +L+ EA ++++LL+RN RLG+ DA +V+ PFFR + WE LLA
Sbjct: 303 DKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLA 362
Query: 891 RRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVA 945
R++ PPF P L DVS FD +FT + P SP D L+ + FL F +VA
Sbjct: 363 RKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSP--DDSTLSESANQVFLGFTYVA 415
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 264 bits (674), Expect = 3e-70
Identities = 143/344 (41%), Positives = 208/344 (60%), Gaps = 8/344 (2%)
Query: 575 DPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGK 634
D P S S E ++ +L S +Q +P K DF FL V+G+G FGK
Sbjct: 120 DSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPT----DFDFLKVIGKGSFGK 175
Query: 635 VLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTP 694
VLL++ + G+ +A+K L+K ++ R E + +M E+ +L + + HPFLV L FQT
Sbjct: 176 VLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVL--LKNVKHPFLVGLHYSFQTT 233
Query: 695 EHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLL 753
E + FV+++ GG+L H+ + F E RA FY+A + L +LH KIVYRDLK +N+L
Sbjct: 234 EKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENIL 293
Query: 754 LDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYE 813
LD+ G+V + DFGLCKEG+ D T+TFCGTPE+LAPEV+ Y VDWW LG +LYE
Sbjct: 294 LDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYE 353
Query: 814 MLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAED 873
ML G PF D E++D+I++ + +S A I+ LL ++ + RLG+ E D +
Sbjct: 354 MLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKE-DFLE 412
Query: 874 VKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGE 917
++ PFF +L W L+ +++PPPF P ++G D+ NFD FT E
Sbjct: 413 IQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEE 456
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 264 bits (674), Expect = 3e-70
Identities = 143/344 (41%), Positives = 208/344 (60%), Gaps = 8/344 (2%)
Query: 575 DPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGK 634
D P S S E ++ +L S +Q +P K DF FL V+G+G FGK
Sbjct: 120 DSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPT----DFDFLKVIGKGSFGK 175
Query: 635 VLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTP 694
VLL++ + G+ +A+K L+K ++ R E + +M E+ +L + + HPFLV L FQT
Sbjct: 176 VLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVL--LKNVKHPFLVGLHYSFQTT 233
Query: 695 EHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLL 753
E + FV+++ GG+L H+ + F E RA FY+A + L +LH KIVYRDLK +N+L
Sbjct: 234 EKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENIL 293
Query: 754 LDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYE 813
LD+ G+V + DFGLCKEG+ D T+TFCGTPE+LAPEV+ Y VDWW LG +LYE
Sbjct: 294 LDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYE 353
Query: 814 MLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAED 873
ML G PF D E++D+I++ + +S A I+ LL ++ + RLG+ E D +
Sbjct: 354 MLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKE-DFLE 412
Query: 874 VKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGE 917
++ PFF +L W L+ +++PPPF P ++G D+ NFD FT E
Sbjct: 413 IQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEE 456
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 260 bits (665), Expect = 4e-69
Identities = 153/402 (38%), Positives = 228/402 (56%), Gaps = 24/402 (5%)
Query: 555 SVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELP-----SETQETPGPALCS 609
+V L+L T+ S + +P SP+ + P+ E A L E + T
Sbjct: 3 AVFDLDLETEEGS---EGEGEPELSPAD-ACPLAELRAAGLEPVGHYEEVELTETSVNVG 58
Query: 610 PLRKSPLTLEDFKFLAVLGRGHFGKVLLS---EFRPSGELFAIKALKKGDIV--ARDEVE 664
P R P F+ L VLG+G +GKV + G+++A+K L+K IV A+D
Sbjct: 59 PERIGP---HCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAH 115
Query: 665 SLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRA 723
+ E+ IL +V HPF+V L FQT + ++E +GG+L H+ + +F E A
Sbjct: 116 T-RAERNILESVK---HPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTA 171
Query: 724 IFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCG 783
FY A + L L LH I+YRDLK +N++L ++G++K+ DFGLCKE + G T TFCG
Sbjct: 172 CFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCG 231
Query: 784 TPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRF 843
T E++APE+L + + RAVDWW LG L+Y+ML G PF ++ ++ D I+ ++ P +
Sbjct: 232 TIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPY 291
Query: 844 LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSG 903
L+ +A ++++ L+RNP +R+G DA DV++ PFFR + W+ LLA R+ PPF P L
Sbjct: 292 LTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQS 351
Query: 904 RTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVA 945
DVS FD FT + P SP D L+ + AFL F +VA
Sbjct: 352 EEDVSQFDTRFTRQTPVDSP--DDTALSESANQAFLGFTYVA 391
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 255 bits (652), Expect = 1e-67
Identities = 142/368 (38%), Positives = 219/368 (59%), Gaps = 15/368 (4%)
Query: 587 IQESTAPELPSETQETPGPALCSPLRKSPLTL-----EDFKFLAVLGRGHFGKVLLSEFR 641
I + PEL + +P P+ + P + DF FL V+G+G FGKVLL+ +
Sbjct: 60 ISQPQEPELMN-ANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHK 118
Query: 642 PSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVM 701
+A+K L+K I+ + E + +M E+ +L + + HPFLV L FQT + + FV+
Sbjct: 119 AEEVFYAVKVLQKKAILKKKEEKHIMSERNVL--LKNVKHPFLVGLHFSFQTADKLYFVL 176
Query: 702 EYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYV 760
+Y GG+L H+ + F EPRA FY+A + L +LH IVYRDLK +N+LLD++G++
Sbjct: 177 DYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHI 236
Query: 761 KIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESP 820
+ DFGLCKE + + TSTFCGTPE+LAPEVL Y R VDWW LG +LYEML G P
Sbjct: 237 VLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPP 296
Query: 821 FPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF 880
F + E++D+I+N ++ ++ A ++ LL+++ +RLG+ + D ++K FF
Sbjct: 297 FYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKD-DFMEIKSHVFF 355
Query: 881 RTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGE--APTLSPPRDARPLTAAEQ--- 935
+ W+ L+ +++ PPF P +SG D+ +FD EFT E ++ D+ +TA+ +
Sbjct: 356 SLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAA 415
Query: 936 AAFLDFDF 943
AFL F +
Sbjct: 416 EAFLGFSY 423
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,019,975
Number of Sequences: 37866
Number of extensions: 2070937
Number of successful extensions: 13438
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 683
Number of HSP's successfully gapped in prelim test: 323
Number of HSP's that attempted gapping in prelim test: 10182
Number of HSP's gapped (non-prelim): 1946
length of query: 948
length of database: 18,247,518
effective HSP length: 112
effective length of query: 836
effective length of database: 14,006,526
effective search space: 11709455736
effective search space used: 11709455736
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.