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Search of human proteins with 47078269
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
(521 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 1042 0.0
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 946 0.0
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 839 0.0
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 240 2e-63
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 238 8e-63
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 233 4e-61
gi|15718708 caspase 8 isoform C precursor [Homo sapiens] 233 4e-61
gi|15718704 caspase 8 isoform A precursor [Homo sapiens] 217 2e-56
gi|15718698 caspase 7 isoform delta [Homo sapiens] 150 2e-36
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 150 2e-36
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 150 2e-36
gi|14790115 caspase 3 preproprotein [Homo sapiens] 121 1e-27
gi|14790119 caspase 3 preproprotein [Homo sapiens] 121 1e-27
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 115 1e-25
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] 114 2e-25
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 108 9e-24
gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1 [... 108 2e-23
gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1 [... 108 2e-23
gi|15718712 caspase 8 isoform E [Homo sapiens] 88 2e-17
gi|14916485 caspase 6 isoform beta [Homo sapiens] 88 2e-17
gi|6912286 caspase 14 precursor [Homo sapiens] 86 1e-16
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 77 4e-14
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 77 4e-14
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 77 4e-14
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 77 4e-14
gi|209870073 caspase 5 isoform c [Homo sapiens] 77 4e-14
gi|209870071 caspase 5 isoform b precursor [Homo sapiens] 77 4e-14
gi|209870069 caspase 5 isoform a precursor [Homo sapiens] 77 4e-14
gi|15718702 caspase 7 isoform beta [Homo sapiens] 65 2e-10
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens] 64 3e-10
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 1042 bits (2694), Expect = 0.0
Identities = 521/521 (100%), Positives = 521/521 (100%)
Query: 1 MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD 60
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD
Sbjct: 1 MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD 60
Query: 61 VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY 120
VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY
Sbjct: 61 VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY 120
Query: 121 ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK 180
ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK
Sbjct: 121 ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK 180
Query: 181 LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSN 240
LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSN
Sbjct: 181 LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSN 240
Query: 241 GNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDR 300
GNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDR
Sbjct: 241 GNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDR 300
Query: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360
QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR
Sbjct: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360
Query: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420
FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE
Sbjct: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420
Query: 421 QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKT 480
QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKT
Sbjct: 421 QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKT 480
Query: 481 MEIRGRKRTVWGAKQISATSLPTAISAQTPRPPMRRWSSVS 521
MEIRGRKRTVWGAKQISATSLPTAISAQTPRPPMRRWSSVS
Sbjct: 481 MEIRGRKRTVWGAKQISATSLPTAISAQTPRPPMRRWSSVS 521
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 946 bits (2444), Expect = 0.0
Identities = 472/472 (100%), Positives = 472/472 (100%)
Query: 1 MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD 60
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD
Sbjct: 1 MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD 60
Query: 61 VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY 120
VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY
Sbjct: 61 VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY 120
Query: 121 ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK 180
ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK
Sbjct: 121 ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK 180
Query: 181 LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSN 240
LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSN
Sbjct: 181 LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSN 240
Query: 241 GNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDR 300
GNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDR
Sbjct: 241 GNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDR 300
Query: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360
QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR
Sbjct: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360
Query: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420
FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE
Sbjct: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420
Query: 421 QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 472
QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR
Sbjct: 421 QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 472
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 839 bits (2168), Expect = 0.0
Identities = 429/472 (90%), Positives = 429/472 (90%), Gaps = 43/472 (9%)
Query: 1 MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD 60
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD
Sbjct: 1 MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD 60
Query: 61 VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY 120
VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY
Sbjct: 61 VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY 120
Query: 121 ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK 180
ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK
Sbjct: 121 ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK 180
Query: 181 LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSN 240
LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALP
Sbjct: 181 LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALP------------ 228
Query: 241 GNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDR 300
RAAVYRMNRNHRGLCVIVNNHSFTSLKDR
Sbjct: 229 -------------------------------RAAVYRMNRNHRGLCVIVNNHSFTSLKDR 257
Query: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360
QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR
Sbjct: 258 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 317
Query: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420
FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE
Sbjct: 318 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 377
Query: 421 QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 472
QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR
Sbjct: 378 QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 429
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 240 bits (613), Expect = 2e-63
Identities = 164/477 (34%), Positives = 238/477 (49%), Gaps = 62/477 (12%)
Query: 17 KVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDP 76
K+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 59 KMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNL 118
Query: 77 FFLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKD 133
FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+
Sbjct: 119 SFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRS 178
Query: 134 MIFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYK 189
FLL++ + K +M L +EK+ + E L L+ +C + LL+ I Y+
Sbjct: 179 FKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYE 238
Query: 190 REKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAP 249
KE S LE P E SNG
Sbjct: 239 E----------FSKERSSS---------------LEGSPDEF-------SNGEELCGVMT 266
Query: 250 SLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFT----------SLKD 299
S Q + + TL+ VY+M RG C+I+NNH+F S++D
Sbjct: 267 ISDSPREQDSESQTLDK--------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRD 318
Query: 300 RQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHG 359
R GTH DA L+ F+ L F + H++ T ++ +L+ + H++ DCF+ CIL+HG
Sbjct: 319 RNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHG 377
Query: 360 RFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNP 419
G +Y +D PI E+ S FT L+CP LA KPK+FFIQACQG+ Q + +E D+
Sbjct: 378 DKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ 437
Query: 420 EQAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 472
L IP EADFLLG+ATV VS+R+ EG+WYIQSLC L++ PR
Sbjct: 438 PYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 494
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 238 bits (608), Expect = 8e-63
Identities = 163/476 (34%), Positives = 237/476 (49%), Gaps = 62/476 (13%)
Query: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134
FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
Query: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKR 190
FLL++ + K +M L +EK+ + E L L+ +C + LL+ I Y+
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
Query: 191 EKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPS 250
KE S LE P E SNG
Sbjct: 181 ----------FSKERSSS---------------LEGSPDEF-------SNGEELCGVMTI 208
Query: 251 LVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFT----------SLKDR 300
S Q + + TL+ VY+M RG C+I+NNH+F S++DR
Sbjct: 209 SDSPREQDSESQTLDK--------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDR 260
Query: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360
GTH DA L+ F+ L F + H++ T ++ +L+ + H++ DCF+ CIL+HG
Sbjct: 261 NGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHGD 319
Query: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420
G +Y +D PI E+ S FT L+CP LA KPK+FFIQACQG+ Q + +E D+
Sbjct: 320 KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQP 379
Query: 421 QAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 472
L IP EADFLLG+ATV VS+R+ EG+WYIQSLC L++ PR
Sbjct: 380 YLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 435
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 233 bits (593), Expect = 4e-61
Identities = 160/476 (33%), Positives = 237/476 (49%), Gaps = 77/476 (16%)
Query: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134
FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
Query: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKR 190
FLL++ + K +M L +EK+ + E L L+ +C + LL+ I Y
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDY-- 178
Query: 191 EKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPS 250
E + EEL V T ++ P+E
Sbjct: 179 ---------------EEFSKGEELCG---VMTISDS-PRE-------------------- 199
Query: 251 LVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFT----------SLKDR 300
Q + + TL+ VY+M RG C+I+NNH+F S++DR
Sbjct: 200 ------QDSESQTLDK--------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDR 245
Query: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360
GTH DA L+ F+ L F + H++ T ++ +L+ + H++ DCF+ CIL+HG
Sbjct: 246 NGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHGD 304
Query: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420
G +Y +D PI E+ S FT L+CP LA KPK+FFIQACQG+ Q + +E D+
Sbjct: 305 KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQP 364
Query: 421 QAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 472
L IP EADFLLG+ATV VS+R+ EG+WYIQSLC L++ PR
Sbjct: 365 YLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420
>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 233 bits (593), Expect = 4e-61
Identities = 160/476 (33%), Positives = 237/476 (49%), Gaps = 77/476 (16%)
Query: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134
FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
Query: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKR 190
FLL++ + K +M L +EK+ + E L L+ +C + LL+ I Y
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDY-- 178
Query: 191 EKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPS 250
E + EEL V T ++ P+E
Sbjct: 179 ---------------EEFSKGEELCG---VMTISDS-PRE-------------------- 199
Query: 251 LVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFT----------SLKDR 300
Q + + TL+ VY+M RG C+I+NNH+F S++DR
Sbjct: 200 ------QDSESQTLDK--------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDR 245
Query: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360
GTH DA L+ F+ L F + H++ T ++ +L+ + H++ DCF+ CIL+HG
Sbjct: 246 NGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHGD 304
Query: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420
G +Y +D PI E+ S FT L+CP LA KPK+FFIQACQG+ Q + +E D+
Sbjct: 305 KGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQP 364
Query: 421 QAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 472
L IP EADFLLG+ATV VS+R+ EG+WYIQSLC L++ PR
Sbjct: 365 YLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPR 420
>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
Length = 496
Score = 217 bits (552), Expect = 2e-56
Identities = 161/508 (31%), Positives = 237/508 (46%), Gaps = 109/508 (21%)
Query: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVS--------------------- 113
FL ELL+ I + LL +LN KEE+ER L P R ++S
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120
Query: 114 -----------LFRNLLYELSEGIDSENLKDMIFLLKDSLPKT----EMTSLSFLAFLEK 158
L R +LY++SE + L+ FLL++ + K +M L +EK
Sbjct: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180
Query: 159 QGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQT 218
+ + E L L+ +C + LL+ I Y E + EEL
Sbjct: 181 RVILGEGKLDILKRVCAQINKSLLKIINDY-----------------EEFSKGEELCG-- 221
Query: 219 DVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRM 278
V T ++ P+E Q + + TL+ VY+M
Sbjct: 222 -VMTISDS-PRE--------------------------QDSESQTLDK--------VYQM 245
Query: 279 NRNHRGLCVIVNNHSFT----------SLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVT 328
RG C+I+NNH+F S++DR GTH DA L+ F+ L F + H++ T
Sbjct: 246 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 305
Query: 329 KVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPR 388
++ +L+ + H++ DCF+ CIL+HG G +Y +D PI E+ S FT L+CP
Sbjct: 306 VEQIYEILKIYQLMD-HSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPS 364
Query: 389 LAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDS----IPAEADFLLGLATVP 444
LA KPK+FFIQACQG+ Q + +E D+ L IP EADFLLG+ATV
Sbjct: 365 LAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVN 424
Query: 445 GYVSFRHVEEGSWYIQSLCNHLKKLVPR 472
VS+R+ EG+WYIQSLC L++ PR
Sbjct: 425 NCVSYRNPAEGTWYIQSLCQSLRERCPR 452
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 150 bits (380), Expect = 2e-36
Identities = 81/223 (36%), Positives = 126/223 (56%), Gaps = 7/223 (3%)
Query: 249 PSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHK 305
PSL S+ + + ++ + Y MN G C+I+NN +F T + R GT K
Sbjct: 66 PSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDK 125
Query: 306 DAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVY 365
DAE L F+ LGF V ++N+ + +M+ +L+K H + CF +L+HG +Y
Sbjct: 126 DAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKAS-EEDHTNAACFACILLSHGEENVIY 184
Query: 366 SSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTS 425
D + PI+++ +HF +C L EKPKLFFIQAC+G E+ + ++ +N A +
Sbjct: 185 GKD-GVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDA--N 241
Query: 426 LQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
+ IP EADFL +TVPGY S+R GSW++Q+LC+ L++
Sbjct: 242 PRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEE 284
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 150 bits (380), Expect = 2e-36
Identities = 81/223 (36%), Positives = 126/223 (56%), Gaps = 7/223 (3%)
Query: 249 PSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHK 305
PSL S+ + + ++ + Y MN G C+I+NN +F T + R GT K
Sbjct: 33 PSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDK 92
Query: 306 DAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVY 365
DAE L F+ LGF V ++N+ + +M+ +L+K H + CF +L+HG +Y
Sbjct: 93 DAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKAS-EEDHTNAACFACILLSHGEENVIY 151
Query: 366 SSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTS 425
D + PI+++ +HF +C L EKPKLFFIQAC+G E+ + ++ +N A +
Sbjct: 152 GKD-GVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDA--N 208
Query: 426 LQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
+ IP EADFL +TVPGY S+R GSW++Q+LC+ L++
Sbjct: 209 PRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEE 251
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 150 bits (380), Expect = 2e-36
Identities = 81/223 (36%), Positives = 126/223 (56%), Gaps = 7/223 (3%)
Query: 249 PSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHK 305
PSL S+ + + ++ + Y MN G C+I+NN +F T + R GT K
Sbjct: 33 PSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDK 92
Query: 306 DAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVY 365
DAE L F+ LGF V ++N+ + +M+ +L+K H + CF +L+HG +Y
Sbjct: 93 DAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKAS-EEDHTNAACFACILLSHGEENVIY 151
Query: 366 SSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTS 425
D + PI+++ +HF +C L EKPKLFFIQAC+G E+ + ++ +N A +
Sbjct: 152 GKD-GVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDA--N 208
Query: 426 LQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
+ IP EADFL +TVPGY S+R GSW++Q+LC+ L++
Sbjct: 209 PRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEE 251
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 121 bits (304), Expect = 1e-27
Identities = 74/227 (32%), Positives = 123/227 (54%), Gaps = 11/227 (4%)
Query: 276 YRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332
Y+M+ GLC+I+NN +F T + R GT DA L F+ L + V N++T+ E+
Sbjct: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
Query: 333 EMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEK 392
+ L + H+ FV +L+HG G ++ ++ + +++I + F +C L K
Sbjct: 97 -VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP-VDLKKITNFFRGDRCRSLTGK 154
Query: 393 PKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 452
PKLF IQAC+G E+ + ++ ++ + A IP EADFL +T PGY S+R+
Sbjct: 155 PKLFIIQACRGTELDCGIETDS-GVDDDMAC----HKIPVEADFLYAYSTAPGYYSWRNS 209
Query: 453 EEGSWYIQSLCNHLKKLVPRMLKFLEKTMEIRGRKRTVWGAKQISAT 499
++GSW+IQSLC LK+ + L+F+ + + T + + AT
Sbjct: 210 KDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFDAT 255
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 121 bits (304), Expect = 1e-27
Identities = 74/227 (32%), Positives = 123/227 (54%), Gaps = 11/227 (4%)
Query: 276 YRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332
Y+M+ GLC+I+NN +F T + R GT DA L F+ L + V N++T+ E+
Sbjct: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
Query: 333 EMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEK 392
+ L + H+ FV +L+HG G ++ ++ + +++I + F +C L K
Sbjct: 97 -VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP-VDLKKITNFFRGDRCRSLTGK 154
Query: 393 PKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 452
PKLF IQAC+G E+ + ++ ++ + A IP EADFL +T PGY S+R+
Sbjct: 155 PKLFIIQACRGTELDCGIETDS-GVDDDMAC----HKIPVEADFLYAYSTAPGYYSWRNS 209
Query: 453 EEGSWYIQSLCNHLKKLVPRMLKFLEKTMEIRGRKRTVWGAKQISAT 499
++GSW+IQSLC LK+ + L+F+ + + T + + AT
Sbjct: 210 KDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFDAT 255
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 115 bits (287), Expect = 1e-25
Identities = 67/200 (33%), Positives = 102/200 (51%), Gaps = 14/200 (7%)
Query: 276 YRMNRNHRGLCVIVNNHSFTSLKD---RQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332
YR+ RGL ++++N FT K+ R G D L +F+ LG+ VH+ + T EM
Sbjct: 192 YRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEM 251
Query: 333 EMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEK 392
+ LQ PAH D + +L+HG GA+Y D L+ ++E+ F CP L K
Sbjct: 252 QEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNK 311
Query: 393 PKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDS----------IPAEADFLLGLAT 442
PK+FFIQAC+G+E V + D N +P + +P +D + G A
Sbjct: 312 PKMFFIQACRGDETDRGVD-QQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 370
Query: 443 VPGYVSFRHVEEGSWYIQSL 462
+ G + R+ + GSWYI++L
Sbjct: 371 LKGTAAMRNTKRGSWYIEAL 390
>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
Length = 293
Score = 114 bits (286), Expect = 2e-25
Identities = 75/227 (33%), Positives = 114/227 (50%), Gaps = 18/227 (7%)
Query: 258 GASANTLNSETSTKR-----AAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEI 309
G N ++ KR A Y+M+ RG+ +I N+ F +L +R+GT D +
Sbjct: 14 GGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDN 73
Query: 310 LSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDE 369
L+ F LGF V N++ E+ + + + +HAD DCFV L+HG +Y+ D
Sbjct: 74 LTRRFSDLGFEVKCFNDLKAEELLLKIHEVS-TVSHADADCFVCVFLSHGEGNHIYAYD- 131
Query: 370 ALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQ-PSVSIEADALNPEQAPTSLQD 428
A I I+ + F +C L KPK+F IQAC+G + P + ++ E+ T++ +
Sbjct: 132 AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITE 191
Query: 429 -------SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
++PA ADFL+ + GY S R GSWYIQ LC L K
Sbjct: 192 VDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGK 238
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 108 bits (271), Expect = 9e-24
Identities = 72/216 (33%), Positives = 108/216 (50%), Gaps = 30/216 (13%)
Query: 276 YRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332
Y ++ G C+I+NN +F + L+ R G++ D E L F L F V + ++T +M
Sbjct: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
Query: 333 EMVLQKQKCNPAHADGDCFVFCILTHG------RF-GAVYSSDEALIPIREIMSHFTALQ 385
+ L + H DC V IL+HG +F GAVY +D + + +I++ F
Sbjct: 213 VLALL-ELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTS 271
Query: 386 CPRLAEKPKLFFIQACQGEE-------IQPSVSIEADALNPEQAPTSLQD---------- 428
CP L KPKLFFIQAC GE+ S E+ NPE T Q+
Sbjct: 272 CPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDA 331
Query: 429 --SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSL 462
S+P +D + +T PG+VS+R + GSWY+++L
Sbjct: 332 ISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL 367
>gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1
[Homo sapiens]
Length = 480
Score = 108 bits (269), Expect = 2e-23
Identities = 129/486 (26%), Positives = 204/486 (41%), Gaps = 73/486 (15%)
Query: 27 IDSNLGVQDVENLKFLC----IGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAEL 82
++ L + E L FLC I +VP + D+ + L LS D LAEL
Sbjct: 9 VEEALDTDEKEMLLFLCRDVAIDVVP-------PNVRDLLDILRERGKLSVGD---LAEL 58
Query: 83 LYIIRQKKLLQH-LNCTKEEVE-RLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKD 140
LY +R+ LL+ L ++ VE LL VS +R L+ E+ E +D ++ +IFL+KD
Sbjct: 59 LYRVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118
Query: 141 SLPK----TEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQI 196
+ + E + L + LEK + D L LE K L+NI + + IQ
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLE--------KCLKNIHRIDLKTKIQ- 169
Query: 197 VTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGM 256
K +S QG + T + L+A Q+S ++ SN R NG
Sbjct: 170 ------KYKQSVQG-----AGTSYRNVLQAAIQKSLKDP---SNNFRLHNGRSKEQRLKE 215
Query: 257 Q-GASANTLNSETSTKRAAV--------YRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDA 307
Q GA + A + Y+M G+C+I++ +
Sbjct: 216 QLGAQQEPVKKSIQESEAFLPQSIPEERYKMKSKPLGICLIIDCIG-----------NET 264
Query: 308 EILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSS 367
E+L F LG+ V +++ + +L + C P H D D FV +++ G +VY
Sbjct: 265 ELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGV 324
Query: 368 DE--ALIPIREIMSHFTALQCPRLAEKPKLFFIQ--ACQGEEIQPSVSIEADALNPEQAP 423
D+ + +P+ I F CP LA KPK+FFIQ +++ S +E D +
Sbjct: 325 DQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVE 384
Query: 424 TSLQD----SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEK 479
Q ++ EADF L T + + S Y+Q L L++ R L+
Sbjct: 385 FKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQ--ERKRPLLDL 442
Query: 480 TMEIRG 485
+E+ G
Sbjct: 443 HIELNG 448
>gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1
[Homo sapiens]
Length = 480
Score = 108 bits (269), Expect = 2e-23
Identities = 129/486 (26%), Positives = 204/486 (41%), Gaps = 73/486 (15%)
Query: 27 IDSNLGVQDVENLKFLC----IGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAEL 82
++ L + E L FLC I +VP + D+ + L LS D LAEL
Sbjct: 9 VEEALDTDEKEMLLFLCRDVAIDVVP-------PNVRDLLDILRERGKLSVGD---LAEL 58
Query: 83 LYIIRQKKLLQH-LNCTKEEVE-RLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKD 140
LY +R+ LL+ L ++ VE LL VS +R L+ E+ E +D ++ +IFL+KD
Sbjct: 59 LYRVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118
Query: 141 SLPK----TEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQI 196
+ + E + L + LEK + D L LE K L+NI + + IQ
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLE--------KCLKNIHRIDLKTKIQ- 169
Query: 197 VTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGM 256
K +S QG + T + L+A Q+S ++ SN R NG
Sbjct: 170 ------KYKQSVQG-----AGTSYRNVLQAAIQKSLKDP---SNNFRLHNGRSKEQRLKE 215
Query: 257 Q-GASANTLNSETSTKRAAV--------YRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDA 307
Q GA + A + Y+M G+C+I++ +
Sbjct: 216 QLGAQQEPVKKSIQESEAFLPQSIPEERYKMKSKPLGICLIIDCIG-----------NET 264
Query: 308 EILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSS 367
E+L F LG+ V +++ + +L + C P H D D FV +++ G +VY
Sbjct: 265 ELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGV 324
Query: 368 DE--ALIPIREIMSHFTALQCPRLAEKPKLFFIQ--ACQGEEIQPSVSIEADALNPEQAP 423
D+ + +P+ I F CP LA KPK+FFIQ +++ S +E D +
Sbjct: 325 DQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVE 384
Query: 424 TSLQD----SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEK 479
Q ++ EADF L T + + S Y+Q L L++ R L+
Sbjct: 385 FKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQ--ERKRPLLDL 442
Query: 480 TMEIRG 485
+E+ G
Sbjct: 443 HIELNG 448
>gi|15718712 caspase 8 isoform E [Homo sapiens]
Length = 235
Score = 87.8 bits (216), Expect = 2e-17
Identities = 58/179 (32%), Positives = 94/179 (52%), Gaps = 7/179 (3%)
Query: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134
FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
Query: 135 IFLLKDSLPK----TEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYK 189
FLL++ + K +M L +EK+ + E L L+ +C + LL+ I Y+
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYE 179
>gi|14916485 caspase 6 isoform beta [Homo sapiens]
Length = 204
Score = 87.8 bits (216), Expect = 2e-17
Identities = 50/133 (37%), Positives = 71/133 (53%), Gaps = 9/133 (6%)
Query: 344 AHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQG 403
+HAD DCFV L+HG +Y+ D A I I+ + F +C L KPK+F IQAC+G
Sbjct: 18 SHADADCFVCVFLSHGEGNHIYAYD-AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRG 76
Query: 404 EEIQ-PSVSIEADALNPEQAPTSLQD-------SIPAEADFLLGLATVPGYVSFRHVEEG 455
+ P + ++ E+ T++ + ++PA ADFL+ + GY S R G
Sbjct: 77 NQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNG 136
Query: 456 SWYIQSLCNHLKK 468
SWYIQ LC L K
Sbjct: 137 SWYIQDLCEMLGK 149
>gi|6912286 caspase 14 precursor [Homo sapiens]
Length = 242
Score = 85.5 bits (210), Expect = 1e-16
Identities = 50/182 (27%), Positives = 88/182 (48%), Gaps = 4/182 (2%)
Query: 298 KDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQK--QKCNPAHADGDCFVFCI 355
K R+G+ +D + L H+F+ L F + + T + + L+K Q + C +
Sbjct: 27 KAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVL 86
Query: 356 LTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEAD 415
+ HGR G + D ++ + + C L KPK++ IQAC+GE+ P ++ D
Sbjct: 87 MAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGD 146
Query: 416 ALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLK 475
+ +IP D L +TV GY+++RH ++GS +IQ+L + K +L+
Sbjct: 147 EI--VMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKGHILE 204
Query: 476 FL 477
L
Sbjct: 205 LL 206
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 77.0 bits (188), Expect = 4e-14
Identities = 58/212 (27%), Positives = 95/212 (44%), Gaps = 14/212 (6%)
Query: 271 KRAAVYR-MNRNHRG-LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVT 328
K A +Y M+++ R L +I+ N F S+ R G D ++ + Q LG++V + N+T
Sbjct: 55 KSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 114
Query: 329 KVEMEMVLQKQKCNPAHADGDCFVFCILTHG-RFGAVYSSDEALIP----IREIMSHFTA 383
+M L+ P H D ++HG R G +P + I +
Sbjct: 115 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 174
Query: 384 LQCPRLAEKPKLFFIQACQGEE-----IQPSVSIEADALNP--EQAPTSLQDSIPAEADF 436
CP L +KPK+ IQAC+G+ + SV + + P E+ E DF
Sbjct: 175 KNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDF 234
Query: 437 LLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
+ ++ P VS+RH GS +I L H+++
Sbjct: 235 IAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQE 266
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 77.0 bits (188), Expect = 4e-14
Identities = 58/212 (27%), Positives = 95/212 (44%), Gaps = 14/212 (6%)
Query: 271 KRAAVYR-MNRNHRG-LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVT 328
K A +Y M+++ R L +I+ N F S+ R G D ++ + Q LG++V + N+T
Sbjct: 148 KSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 207
Query: 329 KVEMEMVLQKQKCNPAHADGDCFVFCILTHG-RFGAVYSSDEALIP----IREIMSHFTA 383
+M L+ P H D ++HG R G +P + I +
Sbjct: 208 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 267
Query: 384 LQCPRLAEKPKLFFIQACQGEE-----IQPSVSIEADALNP--EQAPTSLQDSIPAEADF 436
CP L +KPK+ IQAC+G+ + SV + + P E+ E DF
Sbjct: 268 KNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDF 327
Query: 437 LLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
+ ++ P VS+RH GS +I L H+++
Sbjct: 328 IAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQE 359
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 77.0 bits (188), Expect = 4e-14
Identities = 58/212 (27%), Positives = 95/212 (44%), Gaps = 14/212 (6%)
Query: 271 KRAAVYR-MNRNHRG-LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVT 328
K A +Y M+++ R L +I+ N F S+ R G D ++ + Q LG++V + N+T
Sbjct: 127 KSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 186
Query: 329 KVEMEMVLQKQKCNPAHADGDCFVFCILTHG-RFGAVYSSDEALIP----IREIMSHFTA 383
+M L+ P H D ++HG R G +P + I +
Sbjct: 187 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 246
Query: 384 LQCPRLAEKPKLFFIQACQGEE-----IQPSVSIEADALNP--EQAPTSLQDSIPAEADF 436
CP L +KPK+ IQAC+G+ + SV + + P E+ E DF
Sbjct: 247 KNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDF 306
Query: 437 LLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
+ ++ P VS+RH GS +I L H+++
Sbjct: 307 IAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQE 338
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 77.0 bits (188), Expect = 4e-14
Identities = 64/223 (28%), Positives = 100/223 (44%), Gaps = 21/223 (9%)
Query: 277 RMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVL 336
+ + R L +I+ N F L R G H D + + Q LG+TV N+T +ME VL
Sbjct: 199 KKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVL 258
Query: 337 QKQKCNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAE 391
+ P H D +++HG G + + + + + I F C L +
Sbjct: 259 RAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKD 318
Query: 392 KPKLFFIQACQGE---EIQPSVSIEADALNPEQAPTSLQ-DS---IPAEADFLLGLATVP 444
KPK+ +QAC+GE E+ S + AL Q+ +L+ DS I E DF+ ++ P
Sbjct: 319 KPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTP 378
Query: 445 GYVSFRHVEEGSWYIQSL---------CNHLKKLVPRMLKFLE 478
VS+R GS +I L C HL ++ ++ K E
Sbjct: 379 HNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFE 421
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 77.0 bits (188), Expect = 4e-14
Identities = 64/223 (28%), Positives = 100/223 (44%), Gaps = 21/223 (9%)
Query: 277 RMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVL 336
+ + R L +I+ N F L R G H D + + Q LG+TV N+T +ME VL
Sbjct: 44 KKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVL 103
Query: 337 QKQKCNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAE 391
+ P H D +++HG G + + + + + I F C L +
Sbjct: 104 RAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKD 163
Query: 392 KPKLFFIQACQGE---EIQPSVSIEADALNPEQAPTSLQ-DS---IPAEADFLLGLATVP 444
KPK+ +QAC+GE E+ S + AL Q+ +L+ DS I E DF+ ++ P
Sbjct: 164 KPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTP 223
Query: 445 GYVSFRHVEEGSWYIQSL---------CNHLKKLVPRMLKFLE 478
VS+R GS +I L C HL ++ ++ K E
Sbjct: 224 HNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFE 266
>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
Length = 376
Score = 77.0 bits (188), Expect = 4e-14
Identities = 64/223 (28%), Positives = 100/223 (44%), Gaps = 21/223 (9%)
Query: 277 RMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVL 336
+ + R L +I+ N F L R G H D + + Q LG+TV N+T +ME VL
Sbjct: 128 KKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVL 187
Query: 337 QKQKCNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAE 391
+ P H D +++HG G + + + + + I F C L +
Sbjct: 188 RAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKD 247
Query: 392 KPKLFFIQACQGE---EIQPSVSIEADALNPEQAPTSLQ-DS---IPAEADFLLGLATVP 444
KPK+ +QAC+GE E+ S + AL Q+ +L+ DS I E DF+ ++ P
Sbjct: 248 KPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTP 307
Query: 445 GYVSFRHVEEGSWYIQSL---------CNHLKKLVPRMLKFLE 478
VS+R GS +I L C HL ++ ++ K E
Sbjct: 308 HNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFE 350
>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
Length = 434
Score = 77.0 bits (188), Expect = 4e-14
Identities = 64/223 (28%), Positives = 100/223 (44%), Gaps = 21/223 (9%)
Query: 277 RMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVL 336
+ + R L +I+ N F L R G H D + + Q LG+TV N+T +ME VL
Sbjct: 186 KKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVL 245
Query: 337 QKQKCNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAE 391
+ P H D +++HG G + + + + + I F C L +
Sbjct: 246 RAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKD 305
Query: 392 KPKLFFIQACQGE---EIQPSVSIEADALNPEQAPTSLQ-DS---IPAEADFLLGLATVP 444
KPK+ +QAC+GE E+ S + AL Q+ +L+ DS I E DF+ ++ P
Sbjct: 306 KPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTP 365
Query: 445 GYVSFRHVEEGSWYIQSL---------CNHLKKLVPRMLKFLE 478
VS+R GS +I L C HL ++ ++ K E
Sbjct: 366 HNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFE 408
>gi|15718702 caspase 7 isoform beta [Homo sapiens]
Length = 253
Score = 64.7 bits (156), Expect = 2e-10
Identities = 49/153 (32%), Positives = 75/153 (49%), Gaps = 11/153 (7%)
Query: 249 PSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHK 305
PSL S+ + + ++ + Y MN G C+I+NN +F T + R GT K
Sbjct: 33 PSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDK 92
Query: 306 DAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVY 365
DAE L F+ LGF V ++N+ + +M+ +L+K H + CF +L+HG
Sbjct: 93 DAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKAS-EEDHTNAACFACILLSHGEENMES 151
Query: 366 SS-DEALIPIREIMSHFTALQ--CPRLAEKPKL 395
S +A + R++ LQ PRLAE P L
Sbjct: 152 CSVTQAGVQRRDL----GRLQPPPPRLAEGPSL 180
>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
Length = 377
Score = 63.9 bits (154), Expect = 3e-10
Identities = 73/350 (20%), Positives = 134/350 (38%), Gaps = 31/350 (8%)
Query: 159 QGKIDEDNLTCLEDLCKTVVPKLL-----RNIEKYKREKAIQIVTPPVDKE----AESYQ 209
+G + L LE L K + +L +N+ +K E+ + + + A+S Q
Sbjct: 3 EGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQ 62
Query: 210 GEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETS 269
++ + Q ++TF + H +G + + L E +
Sbjct: 63 EKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERA 122
Query: 270 TKRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTK 329
+ + N R L +I+ N F L R G D + + + L ++V + N+T
Sbjct: 123 EEIYPIKERNNRTR-LALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTA 181
Query: 330 VEMEMVLQKQKCNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTAL 384
+ME L+ P H D +++HG G V+ + + + + I F
Sbjct: 182 RDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNR 241
Query: 385 QCPRLAEKPKLFFIQACQGE-------EIQPSVSIEADALNPEQAPTSLQDSIPAEADFL 437
C L +KPK+ +QAC+G P+ A + + E E DF+
Sbjct: 242 NCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFI 301
Query: 438 LGLATVPGYVSFRHVEEGSWYIQSL---------CNHLKKLVPRMLKFLE 478
++ P VS+R GS +I L C HL+++ ++ + E
Sbjct: 302 AFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFE 351
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,913,117
Number of Sequences: 37866
Number of extensions: 895777
Number of successful extensions: 2747
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 2587
Number of HSP's gapped (non-prelim): 121
length of query: 521
length of database: 18,247,518
effective HSP length: 107
effective length of query: 414
effective length of database: 14,195,856
effective search space: 5877084384
effective search space used: 5877084384
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.