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Search of human proteins with 47078267
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
(479 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 956 0.0
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 936 0.0
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 839 0.0
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 302 5e-82
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 300 2e-81
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 296 4e-80
gi|15718708 caspase 8 isoform C precursor [Homo sapiens] 296 4e-80
gi|15718704 caspase 8 isoform A precursor [Homo sapiens] 280 2e-75
gi|15718698 caspase 7 isoform delta [Homo sapiens] 167 3e-41
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 167 3e-41
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 167 3e-41
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] 132 9e-31
gi|14790115 caspase 3 preproprotein [Homo sapiens] 130 3e-30
gi|14790119 caspase 3 preproprotein [Homo sapiens] 130 3e-30
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 124 1e-28
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 119 5e-27
gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1 [... 104 2e-22
gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1 [... 104 2e-22
gi|14916485 caspase 6 isoform beta [Homo sapiens] 99 6e-21
gi|6912286 caspase 14 precursor [Homo sapiens] 94 3e-19
gi|15718712 caspase 8 isoform E [Homo sapiens] 88 2e-17
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 79 7e-15
gi|209870071 caspase 5 isoform b precursor [Homo sapiens] 79 7e-15
gi|209870069 caspase 5 isoform a precursor [Homo sapiens] 79 7e-15
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 76 6e-14
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 76 6e-14
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 76 6e-14
gi|209870073 caspase 5 isoform c [Homo sapiens] 75 1e-13
gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens] 63 5e-10
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens] 63 5e-10
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 956 bits (2472), Expect = 0.0
Identities = 479/479 (100%), Positives = 479/479 (100%)
Query: 1 MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD 60
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD
Sbjct: 1 MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD 60
Query: 61 VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY 120
VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY
Sbjct: 61 VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY 120
Query: 121 ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK 180
ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK
Sbjct: 121 ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK 180
Query: 181 LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPRAAVYRMNRNHR 240
LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPRAAVYRMNRNHR
Sbjct: 181 LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPRAAVYRMNRNHR 240
Query: 241 GLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNP 300
GLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNP
Sbjct: 241 GLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNP 300
Query: 301 AHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQG 360
AHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQG
Sbjct: 301 AHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQG 360
Query: 361 EEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC 420
EEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC
Sbjct: 361 EEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLC 420
Query: 421 NHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFPVPLDALSL 479
NHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFPVPLDALSL
Sbjct: 421 NHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFPVPLDALSL 479
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 936 bits (2418), Expect = 0.0
Identities = 479/522 (91%), Positives = 479/522 (91%), Gaps = 43/522 (8%)
Query: 1 MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD 60
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD
Sbjct: 1 MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD 60
Query: 61 VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY 120
VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY
Sbjct: 61 VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY 120
Query: 121 ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK 180
ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK
Sbjct: 121 ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK 180
Query: 181 LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALP------------ 228
LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALP
Sbjct: 181 LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSN 240
Query: 229 -------------------------------RAAVYRMNRNHRGLCVIVNNHSFTSLKDR 257
RAAVYRMNRNHRGLCVIVNNHSFTSLKDR
Sbjct: 241 GNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDR 300
Query: 258 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 317
QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR
Sbjct: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360
Query: 318 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 377
FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE
Sbjct: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420
Query: 378 QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSIL 437
QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSIL
Sbjct: 421 QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSIL 480
Query: 438 TAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFPVPLDALSL 479
TAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFPVPLDALSL
Sbjct: 481 TAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFPVPLDALSL 522
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 839 bits (2168), Expect = 0.0
Identities = 429/472 (90%), Positives = 429/472 (90%), Gaps = 43/472 (9%)
Query: 1 MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD 60
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD
Sbjct: 1 MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD 60
Query: 61 VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY 120
VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY
Sbjct: 61 VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY 120
Query: 121 ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK 180
ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK
Sbjct: 121 ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK 180
Query: 181 LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALP------------ 228
LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALP
Sbjct: 181 LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSN 240
Query: 229 -------------------------------RAAVYRMNRNHRGLCVIVNNHSFTSLKDR 257
RAAVYRMNRNHRGLCVIVNNHSFTSLKDR
Sbjct: 241 GNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDR 300
Query: 258 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 317
QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR
Sbjct: 301 QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR 360
Query: 318 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 377
FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE
Sbjct: 361 FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE 420
Query: 378 QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 429
QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR
Sbjct: 421 QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPR 472
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 302 bits (773), Expect = 5e-82
Identities = 185/484 (38%), Positives = 272/484 (56%), Gaps = 35/484 (7%)
Query: 17 KVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDP 76
K+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 59 KMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNL 118
Query: 77 FFLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKD 133
FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+
Sbjct: 119 SFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRS 178
Query: 134 MIFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNI---E 186
FLL++ + K +M L +EK+ + E L L+ +C + LL+ I E
Sbjct: 179 FKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYE 238
Query: 187 KYKREKAIQIVTPPVDKEAESYQGEEEL-----VSQTDVKTFLEALPRAAVYRMNRNHRG 241
++ +E++ + P + + EEL +S + + E+ VY+M RG
Sbjct: 239 EFSKERSSSLEGSP-----DEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRG 293
Query: 242 LCVIVNNHSFT----------SLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEM 291
C+I+NNH+F S++DR GTH DA L+ F+ L F + H++ T ++
Sbjct: 294 YCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYE 353
Query: 292 VLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPK 351
+L+ + H++ DCF+ CIL+HG G +Y +D PI E+ S FT L+CP LA KPK
Sbjct: 354 ILKIYQLMD-HSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPK 412
Query: 352 LFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDS----IPAEADFLLGLATVPGYVSFR 407
+FFIQACQG+ Q + +E D+ L IP EADFLLG+ATV VS+R
Sbjct: 413 VFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYR 472
Query: 408 HVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKK 467
+ EG+WYIQSLC L++ PR +DIL+ILT VN +VS + DK+ KQMPQP FTLRKK
Sbjct: 473 NPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKK 532
Query: 468 LVFP 471
LVFP
Sbjct: 533 LVFP 536
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 300 bits (768), Expect = 2e-81
Identities = 184/483 (38%), Positives = 271/483 (56%), Gaps = 35/483 (7%)
Query: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134
FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
Query: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNI---EK 187
FLL++ + K +M L +EK+ + E L L+ +C + LL+ I E+
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
Query: 188 YKREKAIQIVTPPVDKEAESYQGEEEL-----VSQTDVKTFLEALPRAAVYRMNRNHRGL 242
+ +E++ + P + + EEL +S + + E+ VY+M RG
Sbjct: 181 FSKERSSSLEGSP-----DEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGY 235
Query: 243 CVIVNNHSFT----------SLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMV 292
C+I+NNH+F S++DR GTH DA L+ F+ L F + H++ T ++ +
Sbjct: 236 CLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEI 295
Query: 293 LQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKL 352
L+ + H++ DCF+ CIL+HG G +Y +D PI E+ S FT L+CP LA KPK+
Sbjct: 296 LKIYQLMD-HSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKV 354
Query: 353 FFIQACQGEEIQPSVSIEADALNPEQAPTSLQDS----IPAEADFLLGLATVPGYVSFRH 408
FFIQACQG+ Q + +E D+ L IP EADFLLG+ATV VS+R+
Sbjct: 355 FFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRN 414
Query: 409 VEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKL 468
EG+WYIQSLC L++ PR +DIL+ILT VN +VS + DK+ KQMPQP FTLRKKL
Sbjct: 415 PAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKL 474
Query: 469 VFP 471
VFP
Sbjct: 475 VFP 477
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 296 bits (757), Expect = 4e-80
Identities = 185/479 (38%), Positives = 265/479 (55%), Gaps = 42/479 (8%)
Query: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134
FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
Query: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKY-- 188
FLL++ + K +M L +EK+ + E L L+ +C + LL+ I Y
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
Query: 189 --KREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIV 246
K E+ ++T E++ SQT K VY+M RG C+I+
Sbjct: 181 FSKGEELCGVMT------ISDSPREQDSESQTLDK----------VYQMKSKPRGYCLII 224
Query: 247 NNHSFT----------SLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQ 296
NNH+F S++DR GTH DA L+ F+ L F + H++ T ++ +L+
Sbjct: 225 NNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY 284
Query: 297 KCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQ 356
+ H++ DCF+ CIL+HG G +Y +D PI E+ S FT L+CP LA KPK+FFIQ
Sbjct: 285 QLMD-HSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ 343
Query: 357 ACQGEEIQPSVSIEADALNPEQAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEG 412
ACQG+ Q + +E D+ L IP EADFLLG+ATV VS+R+ EG
Sbjct: 344 ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEG 403
Query: 413 SWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFP 471
+WYIQSLC L++ PR +DIL+ILT VN +VS + DK+ KQMPQP FTLRKKLVFP
Sbjct: 404 TWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFP 462
>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 296 bits (757), Expect = 4e-80
Identities = 185/479 (38%), Positives = 265/479 (55%), Gaps = 42/479 (8%)
Query: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134
FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
Query: 135 IFLLKDSLPKT----EMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKY-- 188
FLL++ + K +M L +EK+ + E L L+ +C + LL+ I Y
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE 180
Query: 189 --KREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIV 246
K E+ ++T E++ SQT K VY+M RG C+I+
Sbjct: 181 FSKGEELCGVMT------ISDSPREQDSESQTLDK----------VYQMKSKPRGYCLII 224
Query: 247 NNHSFT----------SLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQ 296
NNH+F S++DR GTH DA L+ F+ L F + H++ T ++ +L+
Sbjct: 225 NNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY 284
Query: 297 KCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQ 356
+ H++ DCF+ CIL+HG G +Y +D PI E+ S FT L+CP LA KPK+FFIQ
Sbjct: 285 QLMD-HSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQ 343
Query: 357 ACQGEEIQPSVSIEADALNPEQAPTSLQDS----IPAEADFLLGLATVPGYVSFRHVEEG 412
ACQG+ Q + +E D+ L IP EADFLLG+ATV VS+R+ EG
Sbjct: 344 ACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEG 403
Query: 413 SWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFP 471
+WYIQSLC L++ PR +DIL+ILT VN +VS + DK+ KQMPQP FTLRKKLVFP
Sbjct: 404 TWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFP 462
>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
Length = 496
Score = 280 bits (716), Expect = 2e-75
Identities = 186/511 (36%), Positives = 265/511 (51%), Gaps = 74/511 (14%)
Query: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVS--------------------- 113
FL ELL+ I + LL +LN KEE+ER L P R ++S
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQ 120
Query: 114 -----------LFRNLLYELSEGIDSENLKDMIFLLKDSLPK----TEMTSLSFLAFLEK 158
L R +LY++SE + L+ FLL++ + K +M L +EK
Sbjct: 121 SVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEK 180
Query: 159 QGKIDEDNLTCLEDLCKTVVPKLLRNIEKY----KREKAIQIVTPPVDKEAESYQGEEEL 214
+ + E L L+ +C + LL+ I Y K E+ ++T E++
Sbjct: 181 RVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMT------ISDSPREQDS 234
Query: 215 VSQTDVKTFLEALPRAAVYRMNRNHRGLCVIVNNHSFT----------SLKDRQGTHKDA 264
SQT K VY+M RG C+I+NNH+F S++DR GTH DA
Sbjct: 235 ESQTLDK----------VYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDA 284
Query: 265 EILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSS 324
L+ F+ L F + H++ T ++ +L+ + H++ DCF+ CIL+HG G +Y +
Sbjct: 285 GALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMD-HSNMDCFICCILSHGDKGIIYGT 343
Query: 325 DEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQ 384
D PI E+ S FT L+CP LA KPK+FFIQACQG+ Q + +E D+ L
Sbjct: 344 DGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLS 403
Query: 385 DS----IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAV 440
IP EADFLLG+ATV VS+R+ EG+WYIQSLC L++ PR +DIL+ILT V
Sbjct: 404 SPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEV 463
Query: 441 NDDVSRRVDKQGTKKQMPQPAFTLRKKLVFP 471
N +VS + DK+ KQMPQP FTLRKKLVFP
Sbjct: 464 NYEVSNKDDKKNMGKQMPQPTFTLRKKLVFP 494
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 167 bits (422), Expect = 3e-41
Identities = 99/272 (36%), Positives = 153/272 (56%), Gaps = 15/272 (5%)
Query: 208 YQGEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDA 264
+ +++ V+ +KT + +P Y MN G C+I+NN +F T + R GT KDA
Sbjct: 69 FSKKKKNVTMRSIKTTRDRVPTYQ-YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDA 127
Query: 265 EILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSS 324
E L F+ LGF V ++N+ + +M+ +L+K H + CF +L+HG +Y
Sbjct: 128 EALFKCFRSLGFDVIVYNDCSCAKMQDLLKKAS-EEDHTNAACFACILLSHGEENVIYGK 186
Query: 325 DEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQ 384
D + PI+++ +HF +C L EKPKLFFIQAC+G E+ + ++ +N A + +
Sbjct: 187 D-GVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDA--NPR 243
Query: 385 DSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDV 444
IP EADFL +TVPGY S+R GSW++Q+LC+ L++ + +I+ ILT VND V
Sbjct: 244 YKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEE-HGKDLEIMQILTRVNDRV 302
Query: 445 SRRVDKQG------TKKQMPQPAFTLRKKLVF 470
+R + Q KKQ+P L K+L F
Sbjct: 303 ARHFESQSDDPHFHEKKQIPCVVSMLTKELYF 334
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 167 bits (422), Expect = 3e-41
Identities = 99/272 (36%), Positives = 153/272 (56%), Gaps = 15/272 (5%)
Query: 208 YQGEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDA 264
+ +++ V+ +KT + +P Y MN G C+I+NN +F T + R GT KDA
Sbjct: 36 FSKKKKNVTMRSIKTTRDRVPTYQ-YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDA 94
Query: 265 EILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSS 324
E L F+ LGF V ++N+ + +M+ +L+K H + CF +L+HG +Y
Sbjct: 95 EALFKCFRSLGFDVIVYNDCSCAKMQDLLKKAS-EEDHTNAACFACILLSHGEENVIYGK 153
Query: 325 DEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQ 384
D + PI+++ +HF +C L EKPKLFFIQAC+G E+ + ++ +N A + +
Sbjct: 154 D-GVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDA--NPR 210
Query: 385 DSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDV 444
IP EADFL +TVPGY S+R GSW++Q+LC+ L++ + +I+ ILT VND V
Sbjct: 211 YKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEE-HGKDLEIMQILTRVNDRV 269
Query: 445 SRRVDKQG------TKKQMPQPAFTLRKKLVF 470
+R + Q KKQ+P L K+L F
Sbjct: 270 ARHFESQSDDPHFHEKKQIPCVVSMLTKELYF 301
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 167 bits (422), Expect = 3e-41
Identities = 99/272 (36%), Positives = 153/272 (56%), Gaps = 15/272 (5%)
Query: 208 YQGEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDA 264
+ +++ V+ +KT + +P Y MN G C+I+NN +F T + R GT KDA
Sbjct: 36 FSKKKKNVTMRSIKTTRDRVPTYQ-YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDA 94
Query: 265 EILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSS 324
E L F+ LGF V ++N+ + +M+ +L+K H + CF +L+HG +Y
Sbjct: 95 EALFKCFRSLGFDVIVYNDCSCAKMQDLLKKAS-EEDHTNAACFACILLSHGEENVIYGK 153
Query: 325 DEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQ 384
D + PI+++ +HF +C L EKPKLFFIQAC+G E+ + ++ +N A + +
Sbjct: 154 D-GVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDA--NPR 210
Query: 385 DSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDV 444
IP EADFL +TVPGY S+R GSW++Q+LC+ L++ + +I+ ILT VND V
Sbjct: 211 YKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEE-HGKDLEIMQILTRVNDRV 269
Query: 445 SRRVDKQG------TKKQMPQPAFTLRKKLVF 470
+R + Q KKQ+P L K+L F
Sbjct: 270 ARHFESQSDDPHFHEKKQIPCVVSMLTKELYF 301
>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
Length = 293
Score = 132 bits (331), Expect = 9e-31
Identities = 98/278 (35%), Positives = 140/278 (50%), Gaps = 20/278 (7%)
Query: 210 GEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEI 266
G EE +++TD E A Y+M+ RG+ +I N+ F +L +R+GT D +
Sbjct: 14 GGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDN 73
Query: 267 LSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDE 326
L+ F LGF V N++ E+ + + + +HAD DCFV L+HG +Y+ D
Sbjct: 74 LTRRFSDLGFEVKCFNDLKAEELLLKIHEVS-TVSHADADCFVCVFLSHGEGNHIYAYD- 131
Query: 327 ALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQ-PSVSIEADALNPEQAPTSLQD 385
A I I+ + F +C L KPK+F IQAC+G + P + ++ E+ T++ +
Sbjct: 132 AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITE 191
Query: 386 -------SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILT 438
++PA ADFL+ + GY S R GSWYIQ LC L K E +LT
Sbjct: 192 VDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLE-FTELLT 250
Query: 439 AVNDDVS-RRVD-----KQGTKKQMPQPAFTLRKKLVF 470
VN VS RRVD KKQ+P A L KKL F
Sbjct: 251 LVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHF 288
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 130 bits (326), Expect = 3e-30
Identities = 84/247 (34%), Positives = 132/247 (53%), Gaps = 17/247 (6%)
Query: 233 YRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 289
Y+M+ GLC+I+NN +F T + R GT DA L F+ L + V N++T+ E+
Sbjct: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
Query: 290 EMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEK 349
+ L + H+ FV +L+HG G ++ ++ + +++I + F +C L K
Sbjct: 97 -VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP-VDLKKITNFFRGDRCRSLTGK 154
Query: 350 PKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 409
PKLF IQAC+G E+ + ++ ++ + A IP EADFL +T PGY S+R+
Sbjct: 155 PKLFIIQACRGTELDCGIETDS-GVDDDMAC----HKIPVEADFLYAYSTAPGYYSWRNS 209
Query: 410 EEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQG------TKKQMPQPAFT 463
++GSW+IQSLC LK+ + E + ILT VN V+ + KKQ+P
Sbjct: 210 KDGSWFIQSLCAMLKQYADKLE-FMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSM 268
Query: 464 LRKKLVF 470
L K+L F
Sbjct: 269 LTKELYF 275
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 130 bits (326), Expect = 3e-30
Identities = 84/247 (34%), Positives = 132/247 (53%), Gaps = 17/247 (6%)
Query: 233 YRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 289
Y+M+ GLC+I+NN +F T + R GT DA L F+ L + V N++T+ E+
Sbjct: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
Query: 290 EMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEK 349
+ L + H+ FV +L+HG G ++ ++ + +++I + F +C L K
Sbjct: 97 -VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP-VDLKKITNFFRGDRCRSLTGK 154
Query: 350 PKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 409
PKLF IQAC+G E+ + ++ ++ + A IP EADFL +T PGY S+R+
Sbjct: 155 PKLFIIQACRGTELDCGIETDS-GVDDDMAC----HKIPVEADFLYAYSTAPGYYSWRNS 209
Query: 410 EEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQG------TKKQMPQPAFT 463
++GSW+IQSLC LK+ + E + ILT VN V+ + KKQ+P
Sbjct: 210 KDGSWFIQSLCAMLKQYADKLE-FMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSM 268
Query: 464 LRKKLVF 470
L K+L F
Sbjct: 269 LTKELYF 275
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 124 bits (312), Expect = 1e-28
Identities = 107/346 (30%), Positives = 161/346 (46%), Gaps = 48/346 (13%)
Query: 167 LTCLEDLCKTVVPKLLRN------IEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDV 220
++CLED + ++ LR + K E +V P ++ E + E
Sbjct: 74 ISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGS 133
Query: 221 KTF-----LEALPRAA--VYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEILSHV 270
F LE+L A Y ++ G C+I+NN +F + L+ R G++ D E L
Sbjct: 134 GGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRR 193
Query: 271 FQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHG------RF-GAVYS 323
F L F V + ++T +M + L + H DC V IL+HG +F GAVY
Sbjct: 194 FSSLHFMVEVKGDLTAKKMVLALL-ELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYG 252
Query: 324 SDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEE-------IQPSVSIEADALNP 376
+D + + +I++ F CP L KPKLFFIQAC GE+ S E+ NP
Sbjct: 253 TDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNP 312
Query: 377 EQAPTSLQD------------SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLK 424
E T Q+ S+P +D + +T PG+VS+R + GSWY+++L + +
Sbjct: 313 EPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFE 372
Query: 425 KLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVF 470
+ ED+ S+L V + VS +G KQMP LRKKL F
Sbjct: 373 QWA-HSEDLQSLLLRVANAVS----VKGIYKQMPGCFNFLRKKLFF 413
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 119 bits (299), Expect = 5e-27
Identities = 104/354 (29%), Positives = 162/354 (45%), Gaps = 48/354 (13%)
Query: 109 RQRVSLFRNLLYELSEGIDSENLKDMIFLLKDSLPKTEMTSLS----------------F 152
+ RV L + LL LSE ++ KD+I L L + ++ S S F
Sbjct: 42 KNRVVLAKQLL--LSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAF 99
Query: 153 LAFLE-----KQGKIDEDNLTCLEDLCKTVVPKLLRNI---------EKYKREKAIQIVT 198
AF E KQG +++ LT L L + V+P L + E K +++ T
Sbjct: 100 DAFCEALRETKQGHLEDMLLTTLSGL-QHVLPPLSCDYDLSLPFPVCESCPLYKKLRLST 158
Query: 199 PPVDKEAESYQGEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIVNNHSFTSLKD-- 256
V+ ++ G L + F + + A YR+ RGL ++++N FT K+
Sbjct: 159 DTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLA-YRLQSRPRGLALVLSNVHFTGEKELE 217
Query: 257 -RQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTH 315
R G D L +F+ LG+ VH+ + T EM+ LQ PAH D + +L+H
Sbjct: 218 FRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSH 277
Query: 316 GRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALN 375
G GA+Y D L+ ++E+ F CP L KPK+FFIQAC+G+E V + D N
Sbjct: 278 GVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVD-QQDGKN 336
Query: 376 PEQAPTSLQDS----------IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSL 419
+P + +P +D + G A + G + R+ + GSWYI++L
Sbjct: 337 HAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEAL 390
>gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1
[Homo sapiens]
Length = 480
Score = 104 bits (260), Expect = 2e-22
Identities = 131/493 (26%), Positives = 211/493 (42%), Gaps = 75/493 (15%)
Query: 27 IDSNLGVQDVENLKFLC----IGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAEL 82
++ L + E L FLC I +VP + D+ + L LS D LAEL
Sbjct: 9 VEEALDTDEKEMLLFLCRDVAIDVVP-------PNVRDLLDILRERGKLSVGD---LAEL 58
Query: 83 LYIIRQKKLLQH-LNCTKEEVE-RLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKD 140
LY +R+ LL+ L ++ VE LL VS +R L+ E+ E +D ++ +IFL+KD
Sbjct: 59 LYRVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118
Query: 141 SLPK----TEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVP-KLLRNIEKYKR----- 190
+ + E + L + LEK + D L LE K + L I+KYK+
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178
Query: 191 --------EKAIQIVTPPVDKEAESYQG-------EEELVSQTD-VKTFLEA----LPRA 230
+ AIQ + G +E+L +Q + VK ++ LP++
Sbjct: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238
Query: 231 AV---YRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKV 287
Y+M G+C+I++ + E+L F LG+ V +++
Sbjct: 239 IPEERYKMKSKPLGICLIIDCIG-----------NETELLRDTFTSLGYEVQKFLHLSMH 287
Query: 288 EMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDE--ALIPIREIMSHFTALQCPR 345
+ +L + C P H D D FV +++ G +VY D+ + +P+ I F CP
Sbjct: 288 GISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPY 347
Query: 346 LAEKPKLFFIQ--ACQGEEIQPSVSIEADALNPEQAPTSLQD----SIPAEADFLLGLAT 399
LA KPK+FFIQ +++ S +E D + Q ++ EADF L T
Sbjct: 348 LAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCT 407
Query: 400 VPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVND---DVSRRVDKQGTKKQ 456
+ + S Y+Q L L++ R +L + +N D + RV + +K
Sbjct: 408 ADMSLLEQSHSSPSLYLQCLSQKLRQ--ERKRPLLDLHIELNGYMYDWNSRVSAK--EKY 463
Query: 457 MPQPAFTLRKKLV 469
TLRKKL+
Sbjct: 464 YVWLQHTLRKKLI 476
>gi|187608571 CASP8 and FADD-like apoptosis regulator isoform 1
[Homo sapiens]
Length = 480
Score = 104 bits (260), Expect = 2e-22
Identities = 131/493 (26%), Positives = 211/493 (42%), Gaps = 75/493 (15%)
Query: 27 IDSNLGVQDVENLKFLC----IGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAEL 82
++ L + E L FLC I +VP + D+ + L LS D LAEL
Sbjct: 9 VEEALDTDEKEMLLFLCRDVAIDVVP-------PNVRDLLDILRERGKLSVGD---LAEL 58
Query: 83 LYIIRQKKLLQH-LNCTKEEVE-RLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKD 140
LY +R+ LL+ L ++ VE LL VS +R L+ E+ E +D ++ +IFL+KD
Sbjct: 59 LYRVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKD 118
Query: 141 SLPK----TEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVP-KLLRNIEKYKR----- 190
+ + E + L + LEK + D L LE K + L I+KYK+
Sbjct: 119 YMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGA 178
Query: 191 --------EKAIQIVTPPVDKEAESYQG-------EEELVSQTD-VKTFLEA----LPRA 230
+ AIQ + G +E+L +Q + VK ++ LP++
Sbjct: 179 GTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQS 238
Query: 231 AV---YRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKV 287
Y+M G+C+I++ + E+L F LG+ V +++
Sbjct: 239 IPEERYKMKSKPLGICLIIDCIG-----------NETELLRDTFTSLGYEVQKFLHLSMH 287
Query: 288 EMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDE--ALIPIREIMSHFTALQCPR 345
+ +L + C P H D D FV +++ G +VY D+ + +P+ I F CP
Sbjct: 288 GISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPY 347
Query: 346 LAEKPKLFFIQ--ACQGEEIQPSVSIEADALNPEQAPTSLQD----SIPAEADFLLGLAT 399
LA KPK+FFIQ +++ S +E D + Q ++ EADF L T
Sbjct: 348 LAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCT 407
Query: 400 VPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVND---DVSRRVDKQGTKKQ 456
+ + S Y+Q L L++ R +L + +N D + RV + +K
Sbjct: 408 ADMSLLEQSHSSPSLYLQCLSQKLRQ--ERKRPLLDLHIELNGYMYDWNSRVSAK--EKY 463
Query: 457 MPQPAFTLRKKLV 469
TLRKKL+
Sbjct: 464 YVWLQHTLRKKLI 476
>gi|14916485 caspase 6 isoform beta [Homo sapiens]
Length = 204
Score = 99.4 bits (246), Expect = 6e-21
Identities = 71/184 (38%), Positives = 94/184 (51%), Gaps = 16/184 (8%)
Query: 301 AHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQG 360
+HAD DCFV L+HG +Y+ D A I I+ + F +C L KPK+F IQAC+G
Sbjct: 18 SHADADCFVCVFLSHGEGNHIYAYD-AKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRG 76
Query: 361 EEIQ-PSVSIEADALNPEQAPTSLQD-------SIPAEADFLLGLATVPGYVSFRHVEEG 412
+ P + ++ E+ T++ + ++PA ADFL+ + GY S R G
Sbjct: 77 NQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNG 136
Query: 413 SWYIQSLCNHLKKLVPRHEDILSILTAVNDDVS-RRVD-----KQGTKKQMPQPAFTLRK 466
SWYIQ LC L K E +LT VN VS RRVD KKQ+P A L K
Sbjct: 137 SWYIQDLCEMLGKYGSSLE-FTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTK 195
Query: 467 KLVF 470
KL F
Sbjct: 196 KLHF 199
>gi|6912286 caspase 14 precursor [Homo sapiens]
Length = 242
Score = 94.0 bits (232), Expect = 3e-19
Identities = 62/218 (28%), Positives = 105/218 (48%), Gaps = 9/218 (4%)
Query: 255 KDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQK--QKCNPAHADGDCFVFCI 312
K R+G+ +D + L H+F+ L F + + T + + L+K Q + C +
Sbjct: 27 KAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVL 86
Query: 313 LTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEAD 372
+ HGR G + D ++ + + C L KPK++ IQAC+GE+ P ++ D
Sbjct: 87 MAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGD 146
Query: 373 ALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHED 432
+ +IP D L +TV GY+++RH ++GS +IQ+L + K R
Sbjct: 147 EI--VMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK---RKGH 201
Query: 433 ILSILTAVNDDVSRR--VDKQGTKKQMPQPAFTLRKKL 468
IL +LT V ++ V + +K P+ TLRK+L
Sbjct: 202 ILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRL 239
>gi|15718712 caspase 8 isoform E [Homo sapiens]
Length = 235
Score = 87.8 bits (216), Expect = 2e-17
Identities = 58/179 (32%), Positives = 94/179 (52%), Gaps = 7/179 (3%)
Query: 18 VSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPF 77
+ F L I L +D+ +LKFL + +P +K E A +F+ L + +L E +
Sbjct: 1 MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS 60
Query: 78 FLAELLYIIRQKKLL-QHLNCTKEEVERLL--PTRQRVSLFRNLLYELSEGIDSENLKDM 134
FL ELL+ I + LL +LN KEE+ER L P R ++S +R +LY++SE + L+
Sbjct: 61 FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF 120
Query: 135 IFLLKDSLPK----TEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYK 189
FLL++ + K +M L +EK+ + E L L+ +C + LL+ I Y+
Sbjct: 121 KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYE 179
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 79.3 bits (194), Expect = 7e-15
Identities = 80/290 (27%), Positives = 124/290 (42%), Gaps = 32/290 (11%)
Query: 161 KIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDV 220
KI++ L ++ L K V + ++ I V P + EA G E T++
Sbjct: 120 KIEDKALILVDSLRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEA----GPPESAESTNI 175
Query: 221 KTFLEALPRAAVYRM-NRNH------------RGLCVIVNNHSFTSLKDRQGTHKDAEIL 267
L+ PR R+ +NH R L +I+ N F L R G H D +
Sbjct: 176 ---LKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGM 232
Query: 268 SHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRF----GAVYS 323
+ Q LG+TV N+T +ME VL+ P H D +++HG G +
Sbjct: 233 KRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHK 292
Query: 324 SDEALIPIRE-IMSHFTALQCPRLAEKPKLFFIQACQGE---EIQPSVSIEADALNPEQA 379
+ + + + I F C L +KPK+ +QAC+GE E+ S + AL Q+
Sbjct: 293 KKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQS 352
Query: 380 PTSLQ-DS---IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 425
+L+ DS I E DF+ ++ P VS+R GS +I L +K
Sbjct: 353 SENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQK 402
>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
Length = 376
Score = 79.3 bits (194), Expect = 7e-15
Identities = 80/290 (27%), Positives = 124/290 (42%), Gaps = 32/290 (11%)
Query: 161 KIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDV 220
KI++ L ++ L K V + ++ I V P + EA G E T++
Sbjct: 49 KIEDKALILVDSLRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEA----GPPESAESTNI 104
Query: 221 KTFLEALPRAAVYRM-NRNH------------RGLCVIVNNHSFTSLKDRQGTHKDAEIL 267
L+ PR R+ +NH R L +I+ N F L R G H D +
Sbjct: 105 ---LKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGM 161
Query: 268 SHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRF----GAVYS 323
+ Q LG+TV N+T +ME VL+ P H D +++HG G +
Sbjct: 162 KRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHK 221
Query: 324 SDEALIPIRE-IMSHFTALQCPRLAEKPKLFFIQACQGE---EIQPSVSIEADALNPEQA 379
+ + + + I F C L +KPK+ +QAC+GE E+ S + AL Q+
Sbjct: 222 KKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQS 281
Query: 380 PTSLQ-DS---IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 425
+L+ DS I E DF+ ++ P VS+R GS +I L +K
Sbjct: 282 SENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQK 331
>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
Length = 434
Score = 79.3 bits (194), Expect = 7e-15
Identities = 80/290 (27%), Positives = 124/290 (42%), Gaps = 32/290 (11%)
Query: 161 KIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDV 220
KI++ L ++ L K V + ++ I V P + EA G E T++
Sbjct: 107 KIEDKALILVDSLRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEA----GPPESAESTNI 162
Query: 221 KTFLEALPRAAVYRM-NRNH------------RGLCVIVNNHSFTSLKDRQGTHKDAEIL 267
L+ PR R+ +NH R L +I+ N F L R G H D +
Sbjct: 163 ---LKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGM 219
Query: 268 SHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRF----GAVYS 323
+ Q LG+TV N+T +ME VL+ P H D +++HG G +
Sbjct: 220 KRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHK 279
Query: 324 SDEALIPIRE-IMSHFTALQCPRLAEKPKLFFIQACQGE---EIQPSVSIEADALNPEQA 379
+ + + + I F C L +KPK+ +QAC+GE E+ S + AL Q+
Sbjct: 280 KKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQS 339
Query: 380 PTSLQ-DS---IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 425
+L+ DS I E DF+ ++ P VS+R GS +I L +K
Sbjct: 340 SENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQK 389
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 76.3 bits (186), Expect = 6e-14
Identities = 53/196 (27%), Positives = 86/196 (43%), Gaps = 12/196 (6%)
Query: 242 LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPA 301
L +I+ N F S+ R G D ++ + Q LG++V + N+T +M L+ P
Sbjct: 71 LALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPE 130
Query: 302 HADGDCFVFCILTHG-RFGAVYSSDEALIP----IREIMSHFTALQCPRLAEKPKLFFIQ 356
H D ++HG R G +P + I + CP L +KPK+ IQ
Sbjct: 131 HKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQ 190
Query: 357 ACQGEE-----IQPSVSIEADALNP--EQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 409
AC+G+ + SV + + P E+ E DF+ ++ P VS+RH
Sbjct: 191 ACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHP 250
Query: 410 EEGSWYIQSLCNHLKK 425
GS +I L H+++
Sbjct: 251 TMGSVFIGRLIEHMQE 266
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 76.3 bits (186), Expect = 6e-14
Identities = 53/196 (27%), Positives = 86/196 (43%), Gaps = 12/196 (6%)
Query: 242 LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPA 301
L +I+ N F S+ R G D ++ + Q LG++V + N+T +M L+ P
Sbjct: 164 LALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPE 223
Query: 302 HADGDCFVFCILTHG-RFGAVYSSDEALIP----IREIMSHFTALQCPRLAEKPKLFFIQ 356
H D ++HG R G +P + I + CP L +KPK+ IQ
Sbjct: 224 HKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQ 283
Query: 357 ACQGEE-----IQPSVSIEADALNP--EQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 409
AC+G+ + SV + + P E+ E DF+ ++ P VS+RH
Sbjct: 284 ACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHP 343
Query: 410 EEGSWYIQSLCNHLKK 425
GS +I L H+++
Sbjct: 344 TMGSVFIGRLIEHMQE 359
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 76.3 bits (186), Expect = 6e-14
Identities = 53/196 (27%), Positives = 86/196 (43%), Gaps = 12/196 (6%)
Query: 242 LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPA 301
L +I+ N F S+ R G D ++ + Q LG++V + N+T +M L+ P
Sbjct: 143 LALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPE 202
Query: 302 HADGDCFVFCILTHG-RFGAVYSSDEALIP----IREIMSHFTALQCPRLAEKPKLFFIQ 356
H D ++HG R G +P + I + CP L +KPK+ IQ
Sbjct: 203 HKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQ 262
Query: 357 ACQGEE-----IQPSVSIEADALNP--EQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 409
AC+G+ + SV + + P E+ E DF+ ++ P VS+RH
Sbjct: 263 ACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHP 322
Query: 410 EEGSWYIQSLCNHLKK 425
GS +I L H+++
Sbjct: 323 TMGSVFIGRLIEHMQE 338
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 75.5 bits (184), Expect = 1e-13
Identities = 60/204 (29%), Positives = 93/204 (45%), Gaps = 12/204 (5%)
Query: 234 RMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVL 293
+ + R L +I+ N F L R G H D + + Q LG+TV N+T +ME VL
Sbjct: 44 KKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVL 103
Query: 294 QKQKCNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAE 348
+ P H D +++HG G + + + + + I F C L +
Sbjct: 104 RAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKD 163
Query: 349 KPKLFFIQACQGE---EIQPSVSIEADALNPEQAPTSLQ-DS---IPAEADFLLGLATVP 401
KPK+ +QAC+GE E+ S + AL Q+ +L+ DS I E DF+ ++ P
Sbjct: 164 KPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTP 223
Query: 402 GYVSFRHVEEGSWYIQSLCNHLKK 425
VS+R GS +I L +K
Sbjct: 224 HNVSWRDRTRGSIFITELITCFQK 247
>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
Length = 321
Score = 63.2 bits (152), Expect = 5e-10
Identities = 49/200 (24%), Positives = 81/200 (40%), Gaps = 12/200 (6%)
Query: 238 NHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQK 297
N L +I+ N F L R G D + + + L ++V + N+T +ME L+
Sbjct: 77 NRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFA 136
Query: 298 CNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAEKPKL 352
P H D +++HG G V+ + + + + I F C L +KPK+
Sbjct: 137 TRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKV 196
Query: 353 FFIQACQGE-------EIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVS 405
+QAC+G P+ A + + E E DF+ ++ P VS
Sbjct: 197 IIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVS 256
Query: 406 FRHVEEGSWYIQSLCNHLKK 425
+R GS +I L +K
Sbjct: 257 WRDSTMGSIFITQLITCFQK 276
>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
Length = 377
Score = 63.2 bits (152), Expect = 5e-10
Identities = 49/200 (24%), Positives = 81/200 (40%), Gaps = 12/200 (6%)
Query: 238 NHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQK 297
N L +I+ N F L R G D + + + L ++V + N+T +ME L+
Sbjct: 133 NRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFA 192
Query: 298 CNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAEKPKL 352
P H D +++HG G V+ + + + + I F C L +KPK+
Sbjct: 193 TRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKV 252
Query: 353 FFIQACQGE-------EIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVS 405
+QAC+G P+ A + + E E DF+ ++ P VS
Sbjct: 253 IIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVS 312
Query: 406 FRHVEEGSWYIQSLCNHLKK 425
+R GS +I L +K
Sbjct: 313 WRDSTMGSIFITQLITCFQK 332
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,123,167
Number of Sequences: 37866
Number of extensions: 821696
Number of successful extensions: 2248
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 2087
Number of HSP's gapped (non-prelim): 105
length of query: 479
length of database: 18,247,518
effective HSP length: 106
effective length of query: 373
effective length of database: 14,233,722
effective search space: 5309178306
effective search space used: 5309178306
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.