Search of human proteins with 46852398

Search of human proteins with 46852398

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46852398 biogenesis of lysosome-related organelles
complex-1, subunit 2 isoform 1 [Homo sapiens]
         (142 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46852398 biogenesis of lysosome-related organelles complex-1,...   274   2e-74
gi|47717129 biogenesis of lysosome-related organelles complex-1,...   193   5e-50
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    39   0.002
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    39   0.002
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    39   0.002
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    39   0.002
gi|39725717 coiled-coil domain containing 141 [Homo sapiens]           37   0.007
gi|5031937 calcium binding and coiled-coil domain 2 [Homo sapiens]     36   0.009
gi|45505178 cancer antigen 1 [Homo sapiens]                            34   0.047
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    34   0.047
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [...    33   0.061
gi|149363685 hypothetical protein LOC23379 [Homo sapiens]              33   0.10 
gi|42794618 transmembrane protein 81 [Homo sapiens]                    33   0.10 
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     32   0.18 
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    32   0.18 
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    32   0.23 
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    32   0.23 
gi|95147555 microtubule-associated protein 1A [Homo sapiens]           31   0.30 
gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 ...    31   0.39 
gi|221219020 NYD-SP11 protein [Homo sapiens]                           30   0.67 
gi|7662230 ring finger protein 40 [Homo sapiens]                       30   0.67 
gi|96975038 coiled-coil domain containing 100 [Homo sapiens]           30   0.67 
gi|192807292 keratin 24 [Homo sapiens]                                 30   0.88 
gi|151101140 coiled-coil domain containing 2 isoform a [Homo sap...    30   0.88 
gi|151105223 coiled-coil domain containing 2 isoform a [Homo sap...    30   0.88 
gi|151105229 coiled-coil domain containing 2 isoform a [Homo sap...    30   0.88 
gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens]                    29   1.1  
gi|4507651 tropomyosin 4 isoform 2 [Homo sapiens]                      29   1.1  
gi|34577120 mitochondrial translational release factor 1 [Homo s...    29   1.1  
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    29   1.1  

>gi|46852398 biogenesis of lysosome-related organelles complex-1,
           subunit 2 isoform 1 [Homo sapiens]
          Length = 142

 Score =  274 bits (701), Expect = 2e-74
 Identities = 142/142 (100%), Positives = 142/142 (100%)

Query: 1   MAAAAEGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATS 60
           MAAAAEGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATS
Sbjct: 1   MAAAAEGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATS 60

Query: 61  EDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQ 120
           EDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQ
Sbjct: 61  EDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQ 120

Query: 121 AAYKLDAYSKKLEAKYKKLEKR 142
           AAYKLDAYSKKLEAKYKKLEKR
Sbjct: 121 AAYKLDAYSKKLEAKYKKLEKR 142


>gi|47717129 biogenesis of lysosome-related organelles complex-1,
           subunit 2 isoform 2 [Homo sapiens]
          Length = 99

 Score =  193 bits (490), Expect = 5e-50
 Identities = 99/99 (100%), Positives = 99/99 (100%)

Query: 44  MFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQP 103
           MFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQP
Sbjct: 1   MFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQP 60

Query: 104 YLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR 142
           YLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR
Sbjct: 61  YLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR 99


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
           sapiens]
          Length = 1972

 Score = 38.5 bits (88), Expect = 0.002
 Identities = 39/138 (28%), Positives = 64/138 (46%), Gaps = 9/138 (6%)

Query: 11  TRSDEP--ARDDAAVETAEEAKEPAEADITELCR--DMFSKMATYLTGELTATSEDYKLL 66
           TR +E   A++D   +T +E ++ AE ++ EL +     ++    L  +L A +E Y   
Sbjct: 848 TRQEEEMQAKEDELQKT-KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906

Query: 67  ENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQP----YLDQINVIEEQVAALEQAA 122
           E M    + K  E+++I   +   L++   +   LQ        Q+  +EEQ+   E A 
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966

Query: 123 YKLDAYSKKLEAKYKKLE 140
            KL       EAK KKLE
Sbjct: 967 QKLQLEKVTAEAKIKKLE 984



 Score = 27.7 bits (60), Expect = 3.3
 Identities = 34/154 (22%), Positives = 62/154 (40%), Gaps = 23/154 (14%)

Query: 6    EGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSE--DY 63
            E   A  +D+  +    VE+       AE    +L +D+ S     L+ +L  T E    
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS-----LSSQLQDTQELLQE 1326

Query: 64   KLLENMNKLTSLKYLEMKDIAI------------NISRNLKDLNQKYAG----LQPYLDQ 107
            +  + +N  T L+ LE +  ++            N+ R++  LN + +     LQ +   
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386

Query: 108  INVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEK 141
            +  +EE     ++    L    ++  A Y KLEK
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
           sapiens]
          Length = 1979

 Score = 38.5 bits (88), Expect = 0.002
 Identities = 39/138 (28%), Positives = 64/138 (46%), Gaps = 9/138 (6%)

Query: 11  TRSDEP--ARDDAAVETAEEAKEPAEADITELCR--DMFSKMATYLTGELTATSEDYKLL 66
           TR +E   A++D   +T +E ++ AE ++ EL +     ++    L  +L A +E Y   
Sbjct: 855 TRQEEEMQAKEDELQKT-KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913

Query: 67  ENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQP----YLDQINVIEEQVAALEQAA 122
           E M    + K  E+++I   +   L++   +   LQ        Q+  +EEQ+   E A 
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973

Query: 123 YKLDAYSKKLEAKYKKLE 140
            KL       EAK KKLE
Sbjct: 974 QKLQLEKVTAEAKIKKLE 991



 Score = 27.7 bits (60), Expect = 3.3
 Identities = 34/154 (22%), Positives = 62/154 (40%), Gaps = 23/154 (14%)

Query: 6    EGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSE--DY 63
            E   A  +D+  +    VE+       AE    +L +D+ S     L+ +L  T E    
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS-----LSSQLQDTQELLQE 1333

Query: 64   KLLENMNKLTSLKYLEMKDIAI------------NISRNLKDLNQKYAG----LQPYLDQ 107
            +  + +N  T L+ LE +  ++            N+ R++  LN + +     LQ +   
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393

Query: 108  INVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEK 141
            +  +EE     ++    L    ++  A Y KLEK
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
           sapiens]
          Length = 1945

 Score = 38.5 bits (88), Expect = 0.002
 Identities = 39/138 (28%), Positives = 64/138 (46%), Gaps = 9/138 (6%)

Query: 11  TRSDEP--ARDDAAVETAEEAKEPAEADITELCR--DMFSKMATYLTGELTATSEDYKLL 66
           TR +E   A++D   +T +E ++ AE ++ EL +     ++    L  +L A +E Y   
Sbjct: 855 TRQEEEMQAKEDELQKT-KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913

Query: 67  ENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQP----YLDQINVIEEQVAALEQAA 122
           E M    + K  E+++I   +   L++   +   LQ        Q+  +EEQ+   E A 
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973

Query: 123 YKLDAYSKKLEAKYKKLE 140
            KL       EAK KKLE
Sbjct: 974 QKLQLEKVTAEAKIKKLE 991



 Score = 27.7 bits (60), Expect = 3.3
 Identities = 34/154 (22%), Positives = 62/154 (40%), Gaps = 23/154 (14%)

Query: 6    EGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSE--DY 63
            E   A  +D+  +    VE+       AE    +L +D+ S     L+ +L  T E    
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS-----LSSQLQDTQELLQE 1333

Query: 64   KLLENMNKLTSLKYLEMKDIAI------------NISRNLKDLNQKYAG----LQPYLDQ 107
            +  + +N  T L+ LE +  ++            N+ R++  LN + +     LQ +   
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393

Query: 108  INVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEK 141
            +  +EE     ++    L    ++  A Y KLEK
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
           sapiens]
          Length = 1938

 Score = 38.5 bits (88), Expect = 0.002
 Identities = 39/138 (28%), Positives = 64/138 (46%), Gaps = 9/138 (6%)

Query: 11  TRSDEP--ARDDAAVETAEEAKEPAEADITELCR--DMFSKMATYLTGELTATSEDYKLL 66
           TR +E   A++D   +T +E ++ AE ++ EL +     ++    L  +L A +E Y   
Sbjct: 848 TRQEEEMQAKEDELQKT-KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906

Query: 67  ENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQP----YLDQINVIEEQVAALEQAA 122
           E M    + K  E+++I   +   L++   +   LQ        Q+  +EEQ+   E A 
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966

Query: 123 YKLDAYSKKLEAKYKKLE 140
            KL       EAK KKLE
Sbjct: 967 QKLQLEKVTAEAKIKKLE 984



 Score = 27.7 bits (60), Expect = 3.3
 Identities = 34/154 (22%), Positives = 62/154 (40%), Gaps = 23/154 (14%)

Query: 6    EGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSE--DY 63
            E   A  +D+  +    VE+       AE    +L +D+ S     L+ +L  T E    
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS-----LSSQLQDTQELLQE 1326

Query: 64   KLLENMNKLTSLKYLEMKDIAI------------NISRNLKDLNQKYAG----LQPYLDQ 107
            +  + +N  T L+ LE +  ++            N+ R++  LN + +     LQ +   
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386

Query: 108  INVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEK 141
            +  +EE     ++    L    ++  A Y KLEK
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420


>gi|39725717 coiled-coil domain containing 141 [Homo sapiens]
          Length = 875

 Score = 36.6 bits (83), Expect = 0.007
 Identities = 18/68 (26%), Positives = 38/68 (55%)

Query: 74  SLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLE 133
           S++Y  M+D    +  + KD+ +K+  L+    + N     + AL+    ++D Y++K++
Sbjct: 321 SVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQ 380

Query: 134 AKYKKLEK 141
           A  +K+EK
Sbjct: 381 ALKRKMEK 388


>gi|5031937 calcium binding and coiled-coil domain 2 [Homo sapiens]
          Length = 446

 Score = 36.2 bits (82), Expect = 0.009
 Identities = 31/133 (23%), Positives = 58/133 (43%), Gaps = 10/133 (7%)

Query: 19  DDAAVETAEEAKEPAEADITELCRD---------MFSKMATYLTGELTATSEDYKLLENM 69
           +D  V T +   E  E    ELC++            K  + +  EL    E+ + L+++
Sbjct: 131 EDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSI 190

Query: 70  NKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLD-QINVIEEQVAALEQAAYKLDAY 128
           NK   LK  E KD        LK+ NQK +     +  +++ ++ Q++  E+   KL   
Sbjct: 191 NKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQG 250

Query: 129 SKKLEAKYKKLEK 141
            +    + ++L+K
Sbjct: 251 DQDKTEQLEQLKK 263


>gi|45505178 cancer antigen 1 [Homo sapiens]
          Length = 641

 Score = 33.9 bits (76), Expect = 0.047
 Identities = 19/84 (22%), Positives = 42/84 (50%)

Query: 58  ATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAA 117
           A +E  + L++ N+   ++  E++   + + + +K+L  K    Q ++D IN ++E V  
Sbjct: 168 ALNEVLQKLKHTNRKQEVRIQELQCSNLYLEKRVKELQMKITKQQVFIDVINKLKENVEE 227

Query: 118 LEQAAYKLDAYSKKLEAKYKKLEK 141
           L +  YK+       +   + LE+
Sbjct: 228 LIEDKYKIILEKNDTKKTLQNLEE 251


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 33.9 bits (76), Expect = 0.047
 Identities = 33/138 (23%), Positives = 61/138 (44%), Gaps = 7/138 (5%)

Query: 11  TRSDEP--ARDDAAVETAE-EAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLE 67
           TR +E   A+D+  ++  E + K   E +  E       +    L  +L A +E +   E
Sbjct: 848 TRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907

Query: 68  NMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINV----IEEQVAALEQAAY 123
            M    + K  E+++I  ++   +++  ++   LQ    ++      +EEQ+   E A  
Sbjct: 908 EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ 967

Query: 124 KLDAYSKKLEAKYKKLEK 141
           KL       EAK KK+E+
Sbjct: 968 KLQLEKVTAEAKIKKMEE 985


>gi|14165274 golgi-associated microtubule-binding protein HOOK3
           [Homo sapiens]
          Length = 718

 Score = 33.5 bits (75), Expect = 0.061
 Identities = 36/147 (24%), Positives = 65/147 (44%), Gaps = 20/147 (13%)

Query: 15  EPARDDAAVETAEEAKEPAE-----------ADITELCRDMFSKM--ATYLTGELTATSE 61
           E A+DD  +   E  KE +E           AD  +  +D    +  ++    +L    E
Sbjct: 262 EAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVE 321

Query: 62  DYKL-LENMNKLT-SLKYLEMKDI-----AINISRNLKDLNQKYAGLQPYLDQINVIEEQ 114
            YK  LE++  L   +K LE K+       +++   L+  N   + L+ Y  Q+  ++ +
Sbjct: 322 SYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNR 381

Query: 115 VAALEQAAYKLDAYSKKLEAKYKKLEK 141
           ++   + A KLD   K+L+ K   L+K
Sbjct: 382 LSEESKKADKLDFEYKRLKEKVDSLQK 408


>gi|149363685 hypothetical protein LOC23379 [Homo sapiens]
          Length = 2266

 Score = 32.7 bits (73), Expect = 0.10
 Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 4/49 (8%)

Query: 93  DLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEK 141
           +L +K + L+ Y D      ++ A +++   K DA  KKLEAK KKL++
Sbjct: 98  ELEEKKSSLKLYQDT----HQEYARVKEECLKSDAQKKKLEAKVKKLQE 142


>gi|42794618 transmembrane protein 81 [Homo sapiens]
          Length = 255

 Score = 32.7 bits (73), Expect = 0.10
 Identities = 29/116 (25%), Positives = 50/116 (43%), Gaps = 12/116 (10%)

Query: 35  ADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIA-----INISR 89
           +DI E  ++ F        G ++   E +K  +  +     KY +  D       + + +
Sbjct: 107 SDILEFGQEAFRFTWRLARGVISTDDEVFKPFQANSHFVKFKYAQEYDSGTYRCDVQLVK 166

Query: 90  NLKDLNQKYAGLQ---PYLDQIN----VIEEQVAALEQAAYKLDAYSKKLEAKYKK 138
           NL+ + + Y GL+   P L  +N    + E+Q    E     LD+YSK    K+KK
Sbjct: 167 NLRLVKRLYFGLRVLPPNLVNLNFHQSLTEDQKLIDEGLEVNLDSYSKPHHPKWKK 222


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 32.0 bits (71), Expect = 0.18
 Identities = 34/131 (25%), Positives = 59/131 (45%), Gaps = 7/131 (5%)

Query: 17  ARDDAAVETAEEAKEPAEADITELCRDMFSKMAT--YLTGELTATSEDYKLLENMNKLTS 74
           A+++  V+  E+ +  AE  +TE+       MA    L  +L A +E     E +    +
Sbjct: 849 AKEEELVKVREK-QLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLT 907

Query: 75  LKYLEMKDIAINISRNLKDLNQKYAGLQP----YLDQINVIEEQVAALEQAAYKLDAYSK 130
            K  E+++I  ++   +++  ++   LQ         I  +EEQ+   E A  KL     
Sbjct: 908 AKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKV 967

Query: 131 KLEAKYKKLEK 141
             EAK KKLE+
Sbjct: 968 TTEAKLKKLEE 978


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 32.0 bits (71), Expect = 0.18
 Identities = 30/116 (25%), Positives = 54/116 (46%), Gaps = 9/116 (7%)

Query: 34   EADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKD 93
            E +  EL +     + T +T      SE  K  +  N L  L + E++ I +N  R L D
Sbjct: 887  EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH-ELEKIGLNKERLLHD 945

Query: 94   ---LNQKYAGLQPYLDQ-----INVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEK 141
                + +Y  L+  L+      + + EE++AALE    +   Y+++L  + K ++K
Sbjct: 946  EQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK 1001



 Score = 31.6 bits (70), Expect = 0.23
 Identities = 23/86 (26%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 59   TSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQI----NVIEEQ 114
            + ED K  E  ++ T+ + L++KD  I + RN   L  +   L+  L Q+    N ++ Q
Sbjct: 1023 SGEDNKW-ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ 1081

Query: 115  VAALEQAAYKLDAYSKKLEAKYKKLE 140
            + AL++    L   +  L+ +  KL+
Sbjct: 1082 ILALQRQTVSLQEQNTTLQTQNAKLQ 1107



 Score = 30.4 bits (67), Expect = 0.52
 Identities = 21/79 (26%), Positives = 41/79 (51%), Gaps = 4/79 (5%)

Query: 64  KLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAY 123
           K LEN NK       E++D+ +      K+L +    L+    ++  +E++  +LEQ   
Sbjct: 770 KTLENSNKKIQQLESELQDLEMENQTLQKNLEE----LKISSKRLEQLEKENKSLEQETS 825

Query: 124 KLDAYSKKLEAKYKKLEKR 142
           +L+   K+LE + K+L ++
Sbjct: 826 QLEKDKKQLEKENKRLRQQ 844


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 31.6 bits (70), Expect = 0.23
 Identities = 34/140 (24%), Positives = 63/140 (45%), Gaps = 6/140 (4%)

Query: 6    EGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTG----ELTATSE 61
            EG++ ++    A+     E  EE +E   +++    R++  K ++        ELT T  
Sbjct: 910  EGLIKSKILLEAKVKELTERLEEEEE-MNSELVAKKRNLEDKCSSLKRDIDDLELTLTKV 968

Query: 62   DYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQA 121
            + +     NK+ +L   EM  +  NIS+  K+        Q  LD + V E++V  L + 
Sbjct: 969  EKEKHATENKVKNLSE-EMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKI 1027

Query: 122  AYKLDAYSKKLEAKYKKLEK 141
              KL+  +  LE   ++ +K
Sbjct: 1028 NAKLEQQTDDLEGSLEQEKK 1047


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 31.6 bits (70), Expect = 0.23
 Identities = 23/86 (26%), Positives = 43/86 (50%), Gaps = 5/86 (5%)

Query: 59   TSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQI----NVIEEQ 114
            + ED K  E  ++ T+ + L++KD  I + RN   L  +   L+  L Q+    N ++ Q
Sbjct: 1024 SGEDNKW-ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ 1082

Query: 115  VAALEQAAYKLDAYSKKLEAKYKKLE 140
            + AL++    L   +  L+ +  KL+
Sbjct: 1083 ILALQRQTVSLQEQNTTLQTQNAKLQ 1108



 Score = 30.8 bits (68), Expect = 0.39
 Identities = 30/117 (25%), Positives = 54/117 (46%), Gaps = 10/117 (8%)

Query: 34   EADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKD 93
            E +  EL +     + T +T      SE  K  +  N L  L + E++ I +N  R L D
Sbjct: 887  EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH-ELEKIGLNKERLLHD 945

Query: 94   L----NQKYAGLQPYLDQ-----INVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEK 141
                 + +Y  L+  L+      + + EE++AALE    +   Y+++L  + K ++K
Sbjct: 946  EQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK 1002



 Score = 30.4 bits (67), Expect = 0.52
 Identities = 21/79 (26%), Positives = 41/79 (51%), Gaps = 4/79 (5%)

Query: 64  KLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAY 123
           K LEN NK       E++D+ +      K+L +    L+    ++  +E++  +LEQ   
Sbjct: 770 KTLENSNKKIQQLESELQDLEMENQTLQKNLEE----LKISSKRLEQLEKENKSLEQETS 825

Query: 124 KLDAYSKKLEAKYKKLEKR 142
           +L+   K+LE + K+L ++
Sbjct: 826 QLEKDKKQLEKENKRLRQQ 844


>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
          Length = 2803

 Score = 31.2 bits (69), Expect = 0.30
 Identities = 39/152 (25%), Positives = 62/152 (40%), Gaps = 28/152 (18%)

Query: 16   PARDDAAVE-----------TAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYK 64
            PA +D A++           T+E+ KEP   D     +D   +    +  + TA  +  +
Sbjct: 1333 PALEDIAIKWEDKVPGLKDRTSEQKKEPEPKDEVLQQKDKTLEHKEVVEPKDTAIYQKDE 1392

Query: 65   LLENMNKLTSL---------KYLEMKDIAIN-----ISRNLKDLNQKYAGLQPYLDQINV 110
             L   N+             + LE KD A+      +    KDL +K   L+    +  +
Sbjct: 1393 ALHVKNEAVKQQDKALEQKGRDLEQKDTALEQKDKALEPKDKDLEEKDKALE---QKDKI 1449

Query: 111  IEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR 142
             EE+  ALEQ    L+   K LE K K LE++
Sbjct: 1450 PEEKDKALEQKDTALEQKDKALEPKDKDLEQK 1481


>gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2
           [Homo sapiens]
          Length = 1235

 Score = 30.8 bits (68), Expect = 0.39
 Identities = 22/87 (25%), Positives = 42/87 (48%), Gaps = 3/87 (3%)

Query: 52  LTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVI 111
           LT +L  T ++ K +E +      +Y++ K+   N S +LK L+     ++    Q +  
Sbjct: 273 LTRQLQQTEKELKSVETLLNQKRPQYIKAKE---NTSHHLKKLDVAKKSIKDSEKQCSKQ 329

Query: 112 EEQVAALEQAAYKLDAYSKKLEAKYKK 138
           E+ + ALE     LDA  +  E + ++
Sbjct: 330 EDDIKALETELADLDAAWRSFEKQIEE 356


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 30.0 bits (66), Expect = 0.67
 Identities = 32/138 (23%), Positives = 57/138 (41%), Gaps = 4/138 (2%)

Query: 3    AAAEGVLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSED 62
            A  E  LA   ++ A+++  +   E     A   IT+  R+M      +   E T     
Sbjct: 1589 AQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRG 1648

Query: 63   YKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAA 122
             KL +   KL   K  ++      ++R  + L +K   L    +  N++ ++V  L Q  
Sbjct: 1649 EKLSQEAEKLAQ-KRKKLAKKWEKVAREEEKLAKKGGKL---AEVKNILAQKVEELPQRE 1704

Query: 123  YKLDAYSKKLEAKYKKLE 140
              LD   K+L  + ++LE
Sbjct: 1705 QNLDWQEKELAQELEELE 1722


>gi|7662230 ring finger protein 40 [Homo sapiens]
          Length = 1001

 Score = 30.0 bits (66), Expect = 0.67
 Identities = 28/121 (23%), Positives = 53/121 (43%), Gaps = 12/121 (9%)

Query: 21  AAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEM 80
           AAV    EA +  +  + ELC+ ++S+  +    E  A     + L   N+        +
Sbjct: 190 AAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSE--AAQAHTRELGRENR-------RL 240

Query: 81  KDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLE 140
           +D+A  +      ++ +Y+ LQ   D++   E +V  +E     L    +KL  + +KL 
Sbjct: 241 QDLATQLQEKHHRISLEYSELQ---DKVTSAETKVLEMETTVEDLQWDIEKLRKREQKLN 297

Query: 141 K 141
           K
Sbjct: 298 K 298


>gi|96975038 coiled-coil domain containing 100 [Homo sapiens]
          Length = 986

 Score = 30.0 bits (66), Expect = 0.67
 Identities = 25/94 (26%), Positives = 42/94 (44%), Gaps = 2/94 (2%)

Query: 50  TYLTGELTATSEDYKLLEN-MNKLTSLKYLEMKDIAINISRNLKDLNQKYA-GLQPYLDQ 107
           T L G+L  T  D +  E  +  + S    E K++     RNL++L        +  + Q
Sbjct: 706 TILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQ 765

Query: 108 INVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEK 141
           + +   ++  LE+  ++L       E KYK LEK
Sbjct: 766 VELERLKIKQLEEDKHRLQQQLNDAENKYKILEK 799


>gi|192807292 keratin 24 [Homo sapiens]
          Length = 525

 Score = 29.6 bits (65), Expect = 0.88
 Identities = 31/121 (25%), Positives = 57/121 (47%), Gaps = 17/121 (14%)

Query: 24  ETAEEAKEPAEADITELCRDMFSKMATYLTGELT-----ATSEDYKLLENMNKLTSLKYL 78
           E AE+ +  AE        + F+K +  L  +++     ATS   ++ E    L +L+  
Sbjct: 323 ELAEQNRREAE--------ERFNKQSASLQAQISTDAGAATSAKNEITELKRTLQALEIE 374

Query: 79  EMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKK 138
               +A+  S     L    AG   Y+ Q++ I+ Q++ALE+   ++   +K   A+YK+
Sbjct: 375 LQSQLAMKSSLE-GTLADTEAG---YVAQLSEIQTQISALEEEICQIWGETKCQNAEYKQ 430

Query: 139 L 139
           L
Sbjct: 431 L 431


>gi|151101140 coiled-coil domain containing 2 isoform a [Homo
           sapiens]
          Length = 600

 Score = 29.6 bits (65), Expect = 0.88
 Identities = 16/55 (29%), Positives = 30/55 (54%), Gaps = 1/55 (1%)

Query: 89  RNLKDLNQKYAGLQPYL-DQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR 142
           + +KD NQ+ A ++  L D    I + +  + Q    L+ +  ++  KYK+L+KR
Sbjct: 310 KQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKR 364



 Score = 28.1 bits (61), Expect = 2.6
 Identities = 26/138 (18%), Positives = 58/138 (42%), Gaps = 20/138 (14%)

Query: 8   VLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLE 67
           +L  ++D   +    + T  +AKE     + E            +  E  AT +   +++
Sbjct: 175 MLKAQNDRETQSLDVIFTERQAKEKQIRSVEE-----------EIEQEKQATDD---IIK 220

Query: 68  NMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINV------IEEQVAALEQA 121
           NM+    +KYLEMK     + + L  L Q+        + +        ++++   L + 
Sbjct: 221 NMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEK 280

Query: 122 AYKLDAYSKKLEAKYKKL 139
            Y+L+++  ++ A+ K +
Sbjct: 281 LYELESHRDQMIAEDKSI 298


>gi|151105223 coiled-coil domain containing 2 isoform a [Homo
           sapiens]
          Length = 600

 Score = 29.6 bits (65), Expect = 0.88
 Identities = 16/55 (29%), Positives = 30/55 (54%), Gaps = 1/55 (1%)

Query: 89  RNLKDLNQKYAGLQPYL-DQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR 142
           + +KD NQ+ A ++  L D    I + +  + Q    L+ +  ++  KYK+L+KR
Sbjct: 310 KQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKR 364



 Score = 28.1 bits (61), Expect = 2.6
 Identities = 26/138 (18%), Positives = 58/138 (42%), Gaps = 20/138 (14%)

Query: 8   VLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLE 67
           +L  ++D   +    + T  +AKE     + E            +  E  AT +   +++
Sbjct: 175 MLKAQNDRETQSLDVIFTERQAKEKQIRSVEE-----------EIEQEKQATDD---IIK 220

Query: 68  NMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINV------IEEQVAALEQA 121
           NM+    +KYLEMK     + + L  L Q+        + +        ++++   L + 
Sbjct: 221 NMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEK 280

Query: 122 AYKLDAYSKKLEAKYKKL 139
            Y+L+++  ++ A+ K +
Sbjct: 281 LYELESHRDQMIAEDKSI 298


>gi|151105229 coiled-coil domain containing 2 isoform a [Homo
           sapiens]
          Length = 600

 Score = 29.6 bits (65), Expect = 0.88
 Identities = 16/55 (29%), Positives = 30/55 (54%), Gaps = 1/55 (1%)

Query: 89  RNLKDLNQKYAGLQPYL-DQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR 142
           + +KD NQ+ A ++  L D    I + +  + Q    L+ +  ++  KYK+L+KR
Sbjct: 310 KQIKDDNQEIASMERQLTDTKEKINQFIEEIRQLDMDLEEHQGEMNQKYKELKKR 364



 Score = 28.1 bits (61), Expect = 2.6
 Identities = 26/138 (18%), Positives = 58/138 (42%), Gaps = 20/138 (14%)

Query: 8   VLATRSDEPARDDAAVETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLE 67
           +L  ++D   +    + T  +AKE     + E            +  E  AT +   +++
Sbjct: 175 MLKAQNDRETQSLDVIFTERQAKEKQIRSVEE-----------EIEQEKQATDD---IIK 220

Query: 68  NMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINV------IEEQVAALEQA 121
           NM+    +KYLEMK     + + L  L Q+        + +        ++++   L + 
Sbjct: 221 NMSFENQVKYLEMKTTNEKLLQELDTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEK 280

Query: 122 AYKLDAYSKKLEAKYKKL 139
            Y+L+++  ++ A+ K +
Sbjct: 281 LYELESHRDQMIAEDKSI 298


>gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens]
          Length = 284

 Score = 29.3 bits (64), Expect = 1.1
 Identities = 28/119 (23%), Positives = 52/119 (43%), Gaps = 15/119 (12%)

Query: 23  VETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKD 82
           ++ A+   E A+    E+ R +       L GEL    E  ++ E       LK  ++++
Sbjct: 148 LKEAKHIAEEADRKYEEVARKL-----VILEGELERAEERAEVSE-------LKCGDLEE 195

Query: 83  IAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEK 141
              N++ NLK L    A  + Y ++ +  EE++  L     + +  ++  E    KLEK
Sbjct: 196 ELKNVTNNLKSLE---AASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEK 251


>gi|4507651 tropomyosin 4 isoform 2 [Homo sapiens]
          Length = 248

 Score = 29.3 bits (64), Expect = 1.1
 Identities = 28/119 (23%), Positives = 52/119 (43%), Gaps = 15/119 (12%)

Query: 23  VETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKD 82
           ++ A+   E A+    E+ R +       L GEL    E  ++ E       LK  ++++
Sbjct: 112 LKEAKHIAEEADRKYEEVARKL-----VILEGELERAEERAEVSE-------LKCGDLEE 159

Query: 83  IAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEK 141
              N++ NLK L    A  + Y ++ +  EE++  L     + +  ++  E    KLEK
Sbjct: 160 ELKNVTNNLKSLE---AASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEK 215


>gi|34577120 mitochondrial translational release factor 1 [Homo
           sapiens]
          Length = 445

 Score = 29.3 bits (64), Expect = 1.1
 Identities = 20/75 (26%), Positives = 39/75 (52%), Gaps = 5/75 (6%)

Query: 64  KLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAY 123
           K +EN++K        ++ I +N   N + LN+++A L P    +  I +++   EQA  
Sbjct: 77  KYMENLSKEYQTLEQCLQHIPVN-EENRRSLNRRHAELAP----LAAIYQEIQETEQAIE 131

Query: 124 KLDAYSKKLEAKYKK 138
           +L++  K L  + +K
Sbjct: 132 ELESMCKSLNKQDEK 146


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin
           (with transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 29.3 bits (64), Expect = 1.1
 Identities = 24/118 (20%), Positives = 54/118 (45%), Gaps = 10/118 (8%)

Query: 23  VETAEEAKEPAEADITELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKD 82
           VET ++  E  +  +TE+   M  KM      + +   E   L E +N L+  +  + + 
Sbjct: 889 VETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQ 948

Query: 83  IAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLE 140
           +        ++ N+  +GL+   D+++   +   + E+  ++ D   K+ E + +KL+
Sbjct: 949 V--------EEDNEVSSGLKQNYDEMSPAGQ--ISKEELQHEFDLLKKENEQRKRKLQ 996



 Score = 27.3 bits (59), Expect = 4.4
 Identities = 12/30 (40%), Positives = 20/30 (66%)

Query: 104  YLDQINVIEEQVAALEQAAYKLDAYSKKLE 133
            YL QI+ ++E++A LE+   K   +S+ LE
Sbjct: 1838 YLQQIDQLKERIAGLEEEKQKNKEFSQTLE 1867



 Score = 26.2 bits (56), Expect = 9.7
 Identities = 29/100 (29%), Positives = 50/100 (50%), Gaps = 17/100 (17%)

Query: 53   TGELTATSED-YKLLENMNK----LTSLKYL--EMKDIAINISRNLKDLNQKYAG----- 100
            T ELT  SE+ ++L E +NK    + SLK +  E +  A ++ + L+    + AG     
Sbjct: 1329 TSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLR 1388

Query: 101  -LQPYLDQINVI----EEQVAALEQAAYKLDAYSKKLEAK 135
             LQP LD++  +    EE V+ L     + +A   K++ +
Sbjct: 1389 ELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTE 1428


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.125    0.322 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 4,174,760
Number of Sequences: 37866
Number of extensions: 150245
Number of successful extensions: 931
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 72
Number of HSP's that attempted gapping in prelim test: 817
Number of HSP's gapped (non-prelim): 182
length of query: 142
length of database: 18,247,518
effective HSP length: 92
effective length of query: 50
effective length of database: 14,763,846
effective search space: 738192300
effective search space used: 738192300
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 56 (26.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.