Search of human proteins with 46255005

Search of human proteins with 46255005

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46255005 reticulon 2 isoform B [Homo sapiens]
         (472 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46255005 reticulon 2 isoform B [Homo sapiens]                      935   0.0  
gi|5032055 reticulon 2 isoform A [Homo sapiens]                       771   0.0  
gi|46255007 reticulon 2 isoform C [Homo sapiens]                      385   e-107
gi|45827778 reticulon 1 isoform B [Homo sapiens]                      211   2e-54
gi|10863935 reticulon 1 isoform A [Homo sapiens]                      211   2e-54
gi|24431933 reticulon 4 isoform B [Homo sapiens]                      198   1e-50
gi|47519490 reticulon 4 isoform D [Homo sapiens]                      198   1e-50
gi|45827776 reticulon 1 isoform C [Homo sapiens]                      196   5e-50
gi|47519562 reticulon 4 isoform E [Homo sapiens]                      187   2e-47
gi|24431935 reticulon 4 isoform A [Homo sapiens]                      187   2e-47
gi|5902016 reticulon 4 isoform C [Homo sapiens]                       186   3e-47
gi|41393608 reticulon 3 isoform b [Homo sapiens]                      172   5e-43
gi|41393604 reticulon 3 isoform c [Homo sapiens]                      171   1e-42
gi|5174655 reticulon 3 isoform a [Homo sapiens]                       171   1e-42
gi|41393606 reticulon 3 isoform d [Homo sapiens]                      143   3e-34
gi|56676397 ankyrin repeat domain 11 [Homo sapiens]                    47   5e-05
gi|42518068 trans-golgi network protein 2 [Homo sapiens]               47   5e-05
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H...    46   8e-05
gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [H...    46   8e-05
gi|217330641 IWS1 homolog [Homo sapiens]                               44   2e-04
gi|237757312 synaptojanin 1 isoform c [Homo sapiens]                   41   0.003
gi|67188445 CTD (carboxy-terminal domain, RNA polymerase II, pol...    40   0.004
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         40   0.004
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    40   0.006
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...    40   0.006
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi...    40   0.006
gi|188536004 zinc finger protein 469 [Homo sapiens]                    40   0.006
gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E...    40   0.006
gi|41281612 zinc finger protein 828 [Homo sapiens]                     39   0.008
gi|157785645 SPEG complex locus [Homo sapiens]                         39   0.010

>gi|46255005 reticulon 2 isoform B [Homo sapiens]
          Length = 472

 Score =  935 bits (2416), Expect = 0.0
 Identities = 472/472 (100%), Positives = 472/472 (100%)

Query: 1   MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPR 60
           MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPR
Sbjct: 1   MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPR 60

Query: 61  ELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPE 120
           ELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPE
Sbjct: 61  ELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPE 120

Query: 121 PGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLE 180
           PGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLE
Sbjct: 121 PGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLE 180

Query: 181 TGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEE 240
           TGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEE
Sbjct: 181 TGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEE 240

Query: 241 KQWGPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLH 300
           KQWGPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLH
Sbjct: 241 KQWGPLEREPVRGQCLDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLH 300

Query: 301 FSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSH 360
           FSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSH
Sbjct: 301 FSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSH 360

Query: 361 QITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPL 420
           QITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPL
Sbjct: 361 QITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPL 420

Query: 421 LYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE 472
           LYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE
Sbjct: 421 LYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE 472


>gi|5032055 reticulon 2 isoform A [Homo sapiens]
          Length = 545

 Score =  771 bits (1990), Expect = 0.0
 Identities = 424/547 (77%), Positives = 429/547 (78%), Gaps = 77/547 (14%)

Query: 1   MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPR 60
           MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPR
Sbjct: 1   MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPR 60

Query: 61  ELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPE 120
           ELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPE
Sbjct: 61  ELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPE 120

Query: 121 PGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLE 180
           PGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLE
Sbjct: 121 PGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLE 180

Query: 181 TGEAGEELDLRLRLAQPSSPEVL---------TPQLSPGSGTPQAGTPSPS-------RS 224
           TGEAGEELDLRLRLAQPSSPEVL         TPQ   G+ +P     S S         
Sbjct: 181 TGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQA--GTPSPSRSRDSNSGPEEPLLEE 238

Query: 225 RDSNSGPEE-------------------------------------------PLLEEEEK 241
            +   GP E                                           P+LE    
Sbjct: 239 EEKQWGPLEREPVRGQCLDSTDQLEFTVEPRLLGTAMEWLKTSLLLAVYKTVPILELSPP 298

Query: 242 QW--------GPLEREPVRGQCL--------DSTDQLEFTVEPRLLVADLLYWKDTRTSG 285
            W        GP    PV    L             L    +    VADLLYWKDTRTSG
Sbjct: 299 LWTAIGWVQRGPTPPTPVLRVLLKWAKSPRSSGVPSLSLGADMGSKVADLLYWKDTRTSG 358

Query: 286 VVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLD 345
           VVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLD
Sbjct: 359 VVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLD 418

Query: 346 VDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGL 405
           VDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGL
Sbjct: 419 VDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGL 478

Query: 406 TLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVS 465
           TLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVS
Sbjct: 479 TLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVS 538

Query: 466 GSKAKAE 472
           GSKAKAE
Sbjct: 539 GSKAKAE 545


>gi|46255007 reticulon 2 isoform C [Homo sapiens]
          Length = 205

 Score =  385 bits (989), Expect = e-107
 Identities = 201/201 (100%), Positives = 201/201 (100%)

Query: 272 VADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAV 331
           VADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAV
Sbjct: 5   VADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAV 64

Query: 332 HRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALL 391
           HRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALL
Sbjct: 65  HRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALL 124

Query: 392 FYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKI 451
           FYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKI
Sbjct: 125 FYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKI 184

Query: 452 PGTGALASAAAAVSGSKAKAE 472
           PGTGALASAAAAVSGSKAKAE
Sbjct: 185 PGTGALASAAAAVSGSKAKAE 205


>gi|45827778 reticulon 1 isoform B [Homo sapiens]
          Length = 356

 Score =  211 bits (536), Expect = 2e-54
 Identities = 126/314 (40%), Positives = 185/314 (58%), Gaps = 29/314 (9%)

Query: 156 SGEDSSTSSSTPL--EDEEPQEPNRL-----ETGEAGEELDLRLR--------LAQPSSP 200
           S + SS S  +P   +D  P +P+ L     ETG   EE     R        L  PS+ 
Sbjct: 50  SCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTE 109

Query: 201 EVLTPQLSPGSGTPQAGTPS-PSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDST 259
               P+L PG G  +  TP  P +  + +S  + P   +     GP    P         
Sbjct: 110 PQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP--------- 160

Query: 260 DQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTI 319
             L F  + + +  DLLYW+D + +G+VF   ++ L  L  FS+VSV A+LAL  L  TI
Sbjct: 161 --LLFLNKQKAI--DLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATI 216

Query: 320 SLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLV 379
           S R+Y+ VLQAV + D  +PF+AYL++++TL++EQ ++ +  +   V S   +LR  FLV
Sbjct: 217 SFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLV 276

Query: 380 EDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQ 439
           +DLVDSLK A+L ++LT+VGA+FNGLTLL++ V+ +FT+P++Y +HQAQIDQY+GLV   
Sbjct: 277 QDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTH 336

Query: 440 LSHIKAKIRAKIPG 453
           ++ + AKI+AKIPG
Sbjct: 337 INAVVAKIQAKIPG 350


>gi|10863935 reticulon 1 isoform A [Homo sapiens]
          Length = 776

 Score =  211 bits (536), Expect = 2e-54
 Identities = 126/314 (40%), Positives = 185/314 (58%), Gaps = 29/314 (9%)

Query: 156 SGEDSSTSSSTPL--EDEEPQEPNRL-----ETGEAGEELDLRLR--------LAQPSSP 200
           S + SS S  +P   +D  P +P+ L     ETG   EE     R        L  PS+ 
Sbjct: 470 SCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTE 529

Query: 201 EVLTPQLSPGSGTPQAGTPS-PSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDST 259
               P+L PG G  +  TP  P +  + +S  + P   +     GP    P         
Sbjct: 530 PQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP--------- 580

Query: 260 DQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTI 319
             L F  + + +  DLLYW+D + +G+VF   ++ L  L  FS+VSV A+LAL  L  TI
Sbjct: 581 --LLFLNKQKAI--DLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATI 636

Query: 320 SLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLV 379
           S R+Y+ VLQAV + D  +PF+AYL++++TL++EQ ++ +  +   V S   +LR  FLV
Sbjct: 637 SFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLV 696

Query: 380 EDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQ 439
           +DLVDSLK A+L ++LT+VGA+FNGLTLL++ V+ +FT+P++Y +HQAQIDQY+GLV   
Sbjct: 697 QDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTH 756

Query: 440 LSHIKAKIRAKIPG 453
           ++ + AKI+AKIPG
Sbjct: 757 INAVVAKIQAKIPG 770


>gi|24431933 reticulon 4 isoform B [Homo sapiens]
          Length = 373

 Score =  198 bits (503), Expect = 1e-50
 Identities = 132/378 (34%), Positives = 189/378 (50%), Gaps = 37/378 (9%)

Query: 86  PRPQG----RSVSEPRDQHPQPSL-----GDSLESIPSLSQSPEPGRRGDP-DTAPPSER 135
           PRPQ     + V EP D+  +         + LE +  L + P  G    P  TAP +  
Sbjct: 17  PRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGA 76

Query: 136 PLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLA 195
           PL D     D +    RG             PL    P  P R  + +    +   +   
Sbjct: 77  PLMDFGN--DFVPPAPRG-------------PLPAAPPVAPERQPSWDPSP-VSSTVPAP 120

Query: 196 QPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQC 255
            P S   ++P   P    P A  P P         P   +  + E  W P    P     
Sbjct: 121 SPLSAAAVSPSKLPEDDEPPARPPPP---------PPASVSPQAEPVWTPPAPAPAAPPS 171

Query: 256 LDSTDQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLL 315
             +  +   +     +V DLLYW+D + +GVVF   +  LL L  FSIVSV A++AL LL
Sbjct: 172 TPAAPKRRGSSGS--VVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALL 229

Query: 316 CGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRH 375
             TIS R+Y+ V+QA+ + D  +PF+AYL+ ++ ++ E  ++ S+     V     +LR 
Sbjct: 230 SVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRR 289

Query: 376 FFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGL 435
            FLV+DLVDSLK A+L ++ T+VGA+FNGLTLLIL +I LF++P++Y +HQAQID Y+GL
Sbjct: 290 LFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGL 349

Query: 436 VTNQLSHIKAKIRAKIPG 453
               +    AKI+AKIPG
Sbjct: 350 ANKNVKDAMAKIQAKIPG 367


>gi|47519490 reticulon 4 isoform D [Homo sapiens]
          Length = 392

 Score =  198 bits (503), Expect = 1e-50
 Identities = 138/395 (34%), Positives = 194/395 (49%), Gaps = 52/395 (13%)

Query: 86  PRPQG----RSVSEPRDQHPQPSL-----GDSLESIPSLSQSPEPGRRGDP-DTAPPSER 135
           PRPQ     + V EP D+  +         + LE +  L + P  G    P  TAP +  
Sbjct: 17  PRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGA 76

Query: 136 PLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLA 195
           PL D     D +    RG             PL    P  P R  + +    +   +   
Sbjct: 77  PLMDFGN--DFVPPAPRG-------------PLPAAPPVAPERQPSWDPSP-VSSTVPAP 120

Query: 196 QPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEEKQWGP---------- 245
            P S   ++P   P    P A  P P         P   +  + E  W P          
Sbjct: 121 SPLSAAAVSPSKLPEDDEPPARPPPP---------PPASVSPQAEPVWTPPAPAPAAPPS 171

Query: 246 LEREPVRGQCLDSTDQLEFTV----EPRL---LVADLLYWKDTRTSGVVFTGLMVSLLCL 298
               P R     S D+  F +    EP +    V DLLYW+D + +GVVF   +  LL L
Sbjct: 172 TPAAPKRRGSSGSVDETLFALPAASEPVIRSSAVVDLLYWRDIKKTGVVFGASLFLLLSL 231

Query: 299 LHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERL 358
             FSIVSV A++AL LL  TIS R+Y+ V+QA+ + D  +PF+AYL+ ++ ++ E  ++ 
Sbjct: 232 TVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKY 291

Query: 359 SHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTI 418
           S+     V     +LR  FLV+DLVDSLK A+L ++ T+VGA+FNGLTLLIL +I LF++
Sbjct: 292 SNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSV 351

Query: 419 PLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPG 453
           P++Y +HQAQID Y+GL    +    AKI+AKIPG
Sbjct: 352 PVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPG 386


>gi|45827776 reticulon 1 isoform C [Homo sapiens]
          Length = 208

 Score =  196 bits (497), Expect = 5e-50
 Identities = 93/180 (51%), Positives = 136/180 (75%)

Query: 274 DLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHR 333
           DLLYW+D + +G+VF   ++ L  L  FS+VSV A+LAL  L  TIS R+Y+ VLQAV +
Sbjct: 23  DLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQK 82

Query: 334 GDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFY 393
            D  +PF+AYL++++TL++EQ ++ +  +   V S   +LR  FLV+DLVDSLK A+L +
Sbjct: 83  TDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMW 142

Query: 394 ILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPG 453
           +LT+VGA+FNGLTLL++ V+ +FT+P++Y +HQAQIDQY+GLV   ++ + AKI+AKIPG
Sbjct: 143 LLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPG 202


>gi|47519562 reticulon 4 isoform E [Homo sapiens]
          Length = 986

 Score =  187 bits (475), Expect = 2e-47
 Identities = 100/224 (44%), Positives = 144/224 (64%), Gaps = 8/224 (3%)

Query: 231 PEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVE-PRLLVADLLYWKDTRTSGVVFT 289
           P+  + E E+K     E+E       D +    F+ E  +  V DLLYW+D + +GVVF 
Sbjct: 764 PKVLVKEAEKKLPSDTEKE-------DRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFG 816

Query: 290 GLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLT 349
             +  LL L  FSIVSV A++AL LL  TIS R+Y+ V+QA+ + D  +PF+AYL+ ++ 
Sbjct: 817 ASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVA 876

Query: 350 LTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLI 409
           ++ E  ++ S+     V     +LR  FLV+DLVDSLK A+L ++ T+VGA+FNGLTLLI
Sbjct: 877 ISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLI 936

Query: 410 LGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPG 453
           L +I LF++P++Y +HQAQID Y+GL    +    AKI+AKIPG
Sbjct: 937 LALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPG 980


>gi|24431935 reticulon 4 isoform A [Homo sapiens]
          Length = 1192

 Score =  187 bits (475), Expect = 2e-47
 Identities = 100/224 (44%), Positives = 144/224 (64%), Gaps = 8/224 (3%)

Query: 231  PEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVE-PRLLVADLLYWKDTRTSGVVFT 289
            P+  + E E+K     E+E       D +    F+ E  +  V DLLYW+D + +GVVF 
Sbjct: 970  PKVLVKEAEKKLPSDTEKE-------DRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFG 1022

Query: 290  GLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLT 349
              +  LL L  FSIVSV A++AL LL  TIS R+Y+ V+QA+ + D  +PF+AYL+ ++ 
Sbjct: 1023 ASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVA 1082

Query: 350  LTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLI 409
            ++ E  ++ S+     V     +LR  FLV+DLVDSLK A+L ++ T+VGA+FNGLTLLI
Sbjct: 1083 ISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLI 1142

Query: 410  LGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPG 453
            L +I LF++P++Y +HQAQID Y+GL    +    AKI+AKIPG
Sbjct: 1143 LALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPG 1186


>gi|5902016 reticulon 4 isoform C [Homo sapiens]
          Length = 199

 Score =  186 bits (473), Expect = 3e-47
 Identities = 91/182 (50%), Positives = 128/182 (70%)

Query: 272 VADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAV 331
           V DLLYW+D + +GVVF   +  LL L  FSIVSV A++AL LL  TIS R+Y+ V+QA+
Sbjct: 12  VVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAI 71

Query: 332 HRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALL 391
            + D  +PF+AYL+ ++ ++ E  ++ S+     V     +LR  FLV+DLVDSLK A+L
Sbjct: 72  QKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVL 131

Query: 392 FYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKI 451
            ++ T+VGA+FNGLTLLIL +I LF++P++Y +HQAQID Y+GL    +    AKI+AKI
Sbjct: 132 MWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKI 191

Query: 452 PG 453
           PG
Sbjct: 192 PG 193


>gi|41393608 reticulon 3 isoform b [Homo sapiens]
          Length = 1013

 Score =  172 bits (437), Expect = 5e-43
 Identities = 88/202 (43%), Positives = 134/202 (66%), Gaps = 4/202 (1%)

Query: 256  LDSTDQLEFTVEPRLL----VADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLA 311
            L  T+ ++  V  RLL    V DL++W+D + +G VF   ++ LL L  FS++SV ++L 
Sbjct: 805  LSKTELVKKHVLARLLTDFSVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLI 864

Query: 312  LLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAAT 371
            L LL  TIS R+Y+ V+QAV + +  +PF+AYLDVD+TL+ E      +     +  A  
Sbjct: 865  LALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHINRALK 924

Query: 372  QLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQ 431
             +   FLVEDLVDSLKLA+  +++T+VGA+FNG+TLLIL  + +F++P++Y +++ QID 
Sbjct: 925  LIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFSVPIVYEKYKTQIDH 984

Query: 432  YVGLVTNQLSHIKAKIRAKIPG 453
            YVG+  +Q   I  KI+AK+PG
Sbjct: 985  YVGIARDQTKSIVEKIQAKLPG 1006


>gi|41393604 reticulon 3 isoform c [Homo sapiens]
          Length = 255

 Score =  171 bits (433), Expect = 1e-42
 Identities = 82/182 (45%), Positives = 125/182 (68%)

Query: 272 VADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAV 331
           V DL++W+D + +G VF   ++ LL L  FS++SV ++L L LL  TIS R+Y+ V+QAV
Sbjct: 67  VHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQAV 126

Query: 332 HRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALL 391
            + +  +PF+AYLDVD+TL+ E      +     +  A   +   FLVEDLVDSLKLA+ 
Sbjct: 127 QKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVF 186

Query: 392 FYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKI 451
            +++T+VGA+FNG+TLLIL  + +F++P++Y +++ QID YVG+  +Q   I  KI+AK+
Sbjct: 187 MWLMTYVGAVFNGITLLILAELLIFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKL 246

Query: 452 PG 453
           PG
Sbjct: 247 PG 248


>gi|5174655 reticulon 3 isoform a [Homo sapiens]
          Length = 236

 Score =  171 bits (433), Expect = 1e-42
 Identities = 82/182 (45%), Positives = 125/182 (68%)

Query: 272 VADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAV 331
           V DL++W+D + +G VF   ++ LL L  FS++SV ++L L LL  TIS R+Y+ V+QAV
Sbjct: 48  VHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQAV 107

Query: 332 HRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALL 391
            + +  +PF+AYLDVD+TL+ E      +     +  A   +   FLVEDLVDSLKLA+ 
Sbjct: 108 QKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVF 167

Query: 392 FYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKI 451
            +++T+VGA+FNG+TLLIL  + +F++P++Y +++ QID YVG+  +Q   I  KI+AK+
Sbjct: 168 MWLMTYVGAVFNGITLLILAELLIFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKL 227

Query: 452 PG 453
           PG
Sbjct: 228 PG 229


>gi|41393606 reticulon 3 isoform d [Homo sapiens]
          Length = 241

 Score =  143 bits (361), Expect = 3e-34
 Identities = 68/155 (43%), Positives = 107/155 (69%)

Query: 272 VADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAV 331
           V DL++W+D + +G VF   ++ LL L  FS++SV ++L L LL  TIS R+Y+ V+QAV
Sbjct: 48  VHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQAV 107

Query: 332 HRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALL 391
            + +  +PF+AYLDVD+TL+ E      +     +  A   +   FLVEDLVDSLKLA+ 
Sbjct: 108 QKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVF 167

Query: 392 FYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQ 426
            +++T+VGA+FNG+TLLIL  + +F++P++Y +++
Sbjct: 168 MWLMTYVGAVFNGITLLILAELLIFSVPIVYEKYK 202


>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
          Length = 2663

 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 55/237 (23%), Positives = 83/237 (35%), Gaps = 48/237 (20%)

Query: 23   DSTEGGNDDSDFR-----ELHTAREFSEEDEEETTSQDWGTPRELTFSYIAFDGVVGSGG 77
            D+  G  DD D       EL    + + + E E   +    P E+        GV+  G 
Sbjct: 2122 DAFAGPEDDLDLGPFSLPELPLQTKDAADGEAEPVEESLAPPEEMP---PGAPGVINGGD 2178

Query: 78   RRDSTARRPR---PQGRSVSEPRDQHPQPS----LGDSLESIPSLSQSPEPGRRGDPDTA 130
                 A  P    P   S   P +  P+PS    L  +LE+       PE   RGDPD++
Sbjct: 2179 VSTVVAEEPPALPPDQASTRLPAELEPEPSGEPKLDVALEAAVEAETVPEERARGDPDSS 2238

Query: 131  ------PPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTP---LEDEEPQEPNRLET 181
                  PP +RPL                 GSG+  + +   P   L   +   PN +  
Sbjct: 2239 VEPAPVPPEQRPL-----------------GSGDQGAEAEGPPAASLCAPDGPAPNTVAQ 2281

Query: 182  GEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEE 238
             +A +        A P      +   +P  G P    P  +  + +   P+ P +EE
Sbjct: 2282 AQAADG-------AGPEDDTEASRAAAPAEGPPGGIQPEAAEPKPTAEAPKAPRVEE 2331



 Score = 30.0 bits (66), Expect = 4.7
 Identities = 50/240 (20%), Positives = 90/240 (37%), Gaps = 30/240 (12%)

Query: 12  KEAPSTASSTPDSTEGGNDDSDFRE--LHTAR---------------EFSEEDEEETT-- 52
           ++APS A S+  S +G N DS+F +   H A+               EF E+DE++    
Sbjct: 303 EDAPSFAPSS--SVDGNNTDSEFEKGLKHKAKNPEPQKATAPVKDEYEFDEDDEQDRVPP 360

Query: 53  -------SQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSL 105
                   +D+    +   S+I+   +      +++T    +   R +S+  D+      
Sbjct: 361 VDDKHLLKKDYRKETKSN-SFISIPKMEVKSYTKNNTIAPKKASHRILSDTSDEEDASVT 419

Query: 106 GDSLESIPSLSQSPEPGRRG-DPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSS 164
             + E +   + +  PG +  +P  A   +   +  + R           G   D   SS
Sbjct: 420 VGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKGREVRFGKRSDKFCSS 479

Query: 165 STPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRS 224
            +  E  E  E +R   G +G      L L  PS    L+   +   G+  A   +PS +
Sbjct: 480 ESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTSSHGSSAAQKQNPSHT 539


>gi|42518068 trans-golgi network protein 2 [Homo sapiens]
          Length = 437

 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 57/256 (22%), Positives = 98/256 (38%), Gaps = 18/256 (7%)

Query: 16  STASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPRELTFSYIAFDGVVGS 75
           S A +T DST   +      EL T ++ + +   E  + +    R    +    D    S
Sbjct: 114 SEAQTTKDSTSKSHP-----ELQTPKDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSKS 168

Query: 76  GGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSL-ESIPSLS----QSPEPG--RRGDPD 128
           G    +T   P   G     P+D   +    D   + +P+ S    Q+P+ G  + G  +
Sbjct: 169 GSEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPKDVPNKSGAEKQTPKDGSNKSGAEE 228

Query: 129 TAP---PSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAG 185
             P   PS+   E+   + D    V     S +D S   S P +++E  + +  +  + G
Sbjct: 229 QGPIDGPSKSGAEEQTSK-DSPNKVVPEQPSRKDHSKPISNPSDNKELPKADTNQLADKG 287

Query: 186 EELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEE--PLLEEEEKQW 243
           +      +       ++++P       +       P  + D ++GPEE  P  EE+EK  
Sbjct: 288 KLSPHAFKTESGEETDLISPPQEEVKSSEPTEDVEPKEAEDDDTGPEEGSPPKEEKEKMS 347

Query: 244 GPLEREPVRGQCLDST 259
           G    E   G   DST
Sbjct: 348 GSASSENREGTLSDST 363



 Score = 38.1 bits (87), Expect = 0.017
 Identities = 32/125 (25%), Positives = 53/125 (42%), Gaps = 6/125 (4%)

Query: 102 QPSLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSS 161
           +PS G+ + + PSLSQ P    +  P+   P + P +      +          SG ++ 
Sbjct: 34  RPSAGN-VSTHPSLSQRPGGSTKSHPEPQTPKDSPSKS---SAEAQTPEDTPNKSGAEAK 89

Query: 162 TSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTP-- 219
           T   +  +     +  +  T ++G E          S PE+ TP+ S G    +A TP  
Sbjct: 90  TQKDSSNKSGAEAKTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEAQTPED 149

Query: 220 SPSRS 224
           SP+RS
Sbjct: 150 SPNRS 154


>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
           sapiens]
          Length = 756

 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 52/204 (25%), Positives = 84/204 (41%), Gaps = 27/204 (13%)

Query: 47  DEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPR---PQGRSVSEPRDQHPQP 103
           D ++ TS+D G            +G   SGG      +R +   PQ RSVS   ++H  P
Sbjct: 296 DSQKLTSRDSGP-----------NGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSP 344

Query: 104 SLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTS 163
               S++  P   ++  P R   P+ AP S++     ++             S   +STS
Sbjct: 345 VKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTS 404

Query: 164 SSTPLEDEEPQEPNRLETGEAGEEL-------DLRLRLAQPSSPE-VLTPQLSPG-SGTP 214
              P  D+ P  P ++ T E    +       +  L + +PS+PE V + + SP     P
Sbjct: 405 GKIPAPDKVP-TPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPP 463

Query: 215 QAGTPSPSRSRDSNSGPEEPLLEE 238
               P+P   + +  G E P LE+
Sbjct: 464 MDKVPNP---KMAPLGDEAPTLEK 484


>gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [Homo
           sapiens]
          Length = 645

 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 52/204 (25%), Positives = 84/204 (41%), Gaps = 27/204 (13%)

Query: 47  DEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPR---PQGRSVSEPRDQHPQP 103
           D ++ TS+D G            +G   SGG      +R +   PQ RSVS   ++H  P
Sbjct: 185 DSQKLTSRDSGP-----------NGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSP 233

Query: 104 SLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTS 163
               S++  P   ++  P R   P+ AP S++     ++             S   +STS
Sbjct: 234 VKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTS 293

Query: 164 SSTPLEDEEPQEPNRLETGEAGEEL-------DLRLRLAQPSSPE-VLTPQLSPG-SGTP 214
              P  D+ P  P ++ T E    +       +  L + +PS+PE V + + SP     P
Sbjct: 294 GKIPAPDKVP-TPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPP 352

Query: 215 QAGTPSPSRSRDSNSGPEEPLLEE 238
               P+P   + +  G E P LE+
Sbjct: 353 MDKVPNP---KMAPLGDEAPTLEK 373


>gi|217330641 IWS1 homolog [Homo sapiens]
          Length = 819

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 55/268 (20%), Positives = 101/268 (37%), Gaps = 41/268 (15%)

Query: 18  ASSTPDSTEGGND-DSDFRELHTARE---FSEEDEEETTSQDWGTPR---------ELTF 64
           A+   D  + G+D + D  E H+  +        E ET+ ++ G P+         +   
Sbjct: 16  ATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPL 75

Query: 65  SYIAFDGVVGSGGRR-----DSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSP 119
           +  A D       R+     +S  R   P   S +E  +QH   S  +    +P      
Sbjct: 76  NLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSEN 135

Query: 120 EP---GRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEP 176
           E    G   D +     + P  D  +       + +   S  ++  +    + D E +EP
Sbjct: 136 EELLNGHASDSENEDVGKHPASDSEIEE-----LQKSPASDSETEDALKPQISDSESEEP 190

Query: 177 NRLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEE--- 233
            R +  ++  E   + R++   S E+  PQ+S       + +  P R + S+S  EE   
Sbjct: 191 PRHQASDSENEEPPKPRMSDSESEELPKPQVS------DSESEEPPRHQASDSENEELPK 244

Query: 234 PLLEEEEKQWGPLEREPVRGQCLDSTDQ 261
           P + + E +      +P R Q  DS ++
Sbjct: 245 PRISDSESE------DPPRHQASDSENE 266


>gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
          Length = 1295

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 41/146 (28%), Positives = 55/146 (37%), Gaps = 10/146 (6%)

Query: 93   VSEPRDQHPQPSLGDSLESIPSLSQSPEPGRRGDPDTAPP-SERPLEDLRLRLDHLGWVA 151
            V E   QH QPS      S   L  SP    R  P  +P  SE P+  L +R        
Sbjct: 1022 VEELLPQHLQPS------SSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRT 1075

Query: 152  RGTGSGEDS--STSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQLSP 209
             G  S + S      +TPL  ++P +P   +       +    R A P  P   +   SP
Sbjct: 1076 PGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSP 1135

Query: 210  GSGTPQAGTP-SPSRSRDSNSGPEEP 234
                 + G P SP  +R  N G  +P
Sbjct: 1136 APTRKEFGAPKSPGTTRKDNIGRSQP 1161


>gi|67188445 CTD (carboxy-terminal domain, RNA polymerase II,
           polypeptide A) phosphatase, subunit 1 isoform FCP1a
           [Homo sapiens]
          Length = 961

 Score = 40.4 bits (93), Expect = 0.004
 Identities = 37/121 (30%), Positives = 52/121 (42%), Gaps = 13/121 (10%)

Query: 1   MGQVLPVFAHCKEAPSTASSTPDSTEG-GNDDSDFRELHTAREFSEEDEEETTSQDWGTP 59
           M + +P++  CKE   +     D   G G+DDSD     + +   EE EEE   +  GT 
Sbjct: 840 MSETMPLYTLCKEDLESMDKEVDDILGEGSDDSD-----SEKRRPEEQEEEPQPRKPGTR 894

Query: 60  RELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSP 119
           RE T       G   S  R  +  R PR   R ++E  D   + S   S E   S S++ 
Sbjct: 895 RERTL------GAPASSERSAAGGRGPRGHKRKLNE-EDAASESSRESSNEDEGSSSEAD 947

Query: 120 E 120
           E
Sbjct: 948 E 948



 Score = 29.3 bits (64), Expect = 8.1
 Identities = 54/230 (23%), Positives = 81/230 (35%), Gaps = 47/230 (20%)

Query: 66  YIAFDGVVGSG---GRRDSTARRP--RPQGRSVSEP----RD----------------QH 100
           Y+ F G        G R+S  R+     +G  VSEP    RD                + 
Sbjct: 320 YVYFQGTGDMNAPPGSRESQTRKKVNHSRGTEVSEPSPPVRDPEGVTQAPGVEPSNGLEK 379

Query: 101 PQPSLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPL--EDLRLRLDHLGWVARG----- 153
           P   L  S  + P    SP PG+  + D  PP++ P   ++L    +  G  A+G     
Sbjct: 380 PARELNGSEAATPR--DSPRPGKPDERDIWPPAQAPTSSQELAGAPEPQGSCAQGGRVAP 437

Query: 154 --------TGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTP 205
                   TG+  D   SS +     E +      +   GE    R R    ++PE    
Sbjct: 438 GQRPAQGATGTDLDFDLSSDSE-SSSESEGTKSSSSASDGESEGKRGRQKPKAAPEG-AG 495

Query: 206 QLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQC 255
            L+ GS        +PS   ++  G   P   ++E + G  E     G C
Sbjct: 496 ALAQGSSLEPGRPAAPSLPGEAEPGAHAP---DKEPELGGQEEGERDGLC 542


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 40.4 bits (93), Expect = 0.004
 Identities = 40/150 (26%), Positives = 59/150 (39%), Gaps = 5/150 (3%)

Query: 79  RDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPLE 138
           R  +  R R +  S + PR +H   S   S    PS  + P P RR  P   PP  R   
Sbjct: 281 RSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRH-- 338

Query: 139 DLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPS 198
             R     +    R + S   SS+SSS+      P++P +  +    +   L    + P 
Sbjct: 339 --RRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPR 396

Query: 199 SPEVLTPQLSPGSGTPQAGTPSPS-RSRDS 227
                +P  +P   T  + TP  S R+R S
Sbjct: 397 RRHRPSPPATPPPKTRHSPTPQQSNRTRKS 426



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 37/160 (23%), Positives = 55/160 (34%), Gaps = 21/160 (13%)

Query: 75  SGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPEPGRRGDPDTAPPSE 134
           S  R    AR P+P  R    PR + PQ             S SP P RRG   +    +
Sbjct: 665 SPSRSTREARSPQPNKRHSPSPRPRAPQ------------TSSSPPPVRRGASSSPQRRQ 712

Query: 135 RPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRL 194
            P    R        + R + + E      +     +  +  +   +     E   +   
Sbjct: 713 SPSPSTRP-------IRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPP 765

Query: 195 AQPSSPEVLTPQL--SPGSGTPQAGTPSPSRSRDSNSGPE 232
           A PS  +  +P    SP     +A +P+PS S   NS  E
Sbjct: 766 APPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQE 805


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
           sapiens]
          Length = 1293

 Score = 39.7 bits (91), Expect = 0.006
 Identities = 46/160 (28%), Positives = 68/160 (42%), Gaps = 23/160 (14%)

Query: 84  RRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPLEDLRLR 143
           RR R    S+ + RD  P+  L D+ E + +   S            P  E    D R  
Sbjct: 263 RRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFR-- 320

Query: 144 LDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVL 203
                        GE+ S S  +   +EE +EP++    E GE+ D   R+   +S E  
Sbjct: 321 ---------PVDEGEECSDSEGS--HNEEAKEPDKTNKKE-GEKTD---RVGVEASEE-- 363

Query: 204 TPQLSPGSGTPQAGTPSPSRSRDSN--SGPEEPLLEEEEK 241
           TPQ S  S  P  GTPS  +S++++     +EP  E+ EK
Sbjct: 364 TPQTSSSSARP--GTPSDHQSQEASQFERKDEPKTEQTEK 401


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 39.7 bits (91), Expect = 0.006
 Identities = 46/160 (28%), Positives = 68/160 (42%), Gaps = 23/160 (14%)

Query: 84  RRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPLEDLRLR 143
           RR R    S+ + RD  P+  L D+ E + +   S            P  E    D R  
Sbjct: 269 RRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFR-- 326

Query: 144 LDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVL 203
                        GE+ S S  +   +EE +EP++    E GE+ D   R+   +S E  
Sbjct: 327 ---------PVDEGEECSDSEGS--HNEEAKEPDKTNKKE-GEKTD---RVGVEASEE-- 369

Query: 204 TPQLSPGSGTPQAGTPSPSRSRDSN--SGPEEPLLEEEEK 241
           TPQ S  S  P  GTPS  +S++++     +EP  E+ EK
Sbjct: 370 TPQTSSSSARP--GTPSDHQSQEASQFERKDEPKTEQTEK 407


>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 39.7 bits (91), Expect = 0.006
 Identities = 46/160 (28%), Positives = 68/160 (42%), Gaps = 23/160 (14%)

Query: 84  RRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPLEDLRLR 143
           RR R    S+ + RD  P+  L D+ E + +   S            P  E    D R  
Sbjct: 269 RRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFR-- 326

Query: 144 LDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVL 203
                        GE+ S S  +   +EE +EP++    E GE+ D   R+   +S E  
Sbjct: 327 ---------PVDEGEECSDSEGS--HNEEAKEPDKTNKKE-GEKTD---RVGVEASEE-- 369

Query: 204 TPQLSPGSGTPQAGTPSPSRSRDSN--SGPEEPLLEEEEK 241
           TPQ S  S  P  GTPS  +S++++     +EP  E+ EK
Sbjct: 370 TPQTSSSSARP--GTPSDHQSQEASQFERKDEPKTEQTEK 407


>gi|188536004 zinc finger protein 469 [Homo sapiens]
          Length = 3925

 Score = 39.7 bits (91), Expect = 0.006
 Identities = 48/187 (25%), Positives = 66/187 (35%), Gaps = 48/187 (25%)

Query: 78  RRDSTARRPRPQGRSVSEPRDQHPQPSLGD-SLESIPSLSQSPEPGRRGDPDTAPPSERP 136
           R    AR    Q +++  P  Q  Q   G+    S+   + S  PG+RG P T PP   P
Sbjct: 43  RTTKGAREAGGQAQAMELPEAQPRQARDGELKPPSLRGQAPSSTPGKRGSPQT-PPGRSP 101

Query: 137 LEDLRLRLDHLGWVARGTGSGEDS---------STSSSTPLEDEEPQEPN---------- 177
           L+            +R  G  E S         ++S + P  DE P+ P           
Sbjct: 102 LQA----------PSRLAGRAEGSPPQRYILGIASSRTKPTLDETPENPQLEAAQLPEVD 151

Query: 178 ----------------RLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSP 221
                           R E   A EEL       +P S    T   SP S TP+   P P
Sbjct: 152 TPQGPGTGAPLRPGLPRTEAQPAAEELGFHRCFQEPPSSFTSTNYTSP-SATPRPPAPGP 210

Query: 222 SRSRDSN 228
            +SR ++
Sbjct: 211 PQSRGTS 217



 Score = 36.2 bits (82), Expect = 0.066
 Identities = 53/216 (24%), Positives = 74/216 (34%), Gaps = 45/216 (20%)

Query: 42   EFSEEDEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHP 101
            +F+ E EE+      G           F G  G G +R        P+     +PR    
Sbjct: 1065 DFASESEEDEQPPPRGP---------GFRGRRGRGEKRKEVELTQGPREDEPQKPRKAAR 1115

Query: 102  QPSLGDSLESIPSLSQSPEPG--------------------RRGDPDTAP-PSERPLEDL 140
            Q + GD   + P       PG                    R G P  A  PS  P + L
Sbjct: 1116 QEAGGDGAPANPEEPGGSRPGPGRSPQARGPSRSLETGAAAREGGPKCADRPSVAPKDPL 1175

Query: 141  RLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQ-----EPNRLETGEAGEELDLRLRLA 195
            +        V   T + E++  S   P E +EP+      P+  E  EA           
Sbjct: 1176 Q--------VPTNTETSEETRPSLDFPQEAKEPETAEESAPDSTEFTEALRSPPAACAGE 1227

Query: 196  QPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGP 231
              +SP +L P+  P S     GTP PS S  +N+ P
Sbjct: 1228 MGASPGLLIPEQPPPS-RHDTGTPKPSGSL-ANTAP 1261



 Score = 31.2 bits (69), Expect = 2.1
 Identities = 41/160 (25%), Positives = 59/160 (36%), Gaps = 22/160 (13%)

Query: 86   PRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPEPGRR-GDPDTAPPSERPLEDLRLRL 144
            P PQ R        H  P       S  S S +   G R G   TA P+E P        
Sbjct: 2278 PDPQSRGAPP----HTNPDRMPRGHSSYSPSNTARLGHREGQAVTAVPTEPP-------- 2325

Query: 145  DHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLT 204
                   +G G    +          +EP++P   ETG +G       R+  PS+   L 
Sbjct: 2326 -----TLQGAGPDSPACLEGEMGTSSKEPEDPGTPETGRSG--ATKMPRVTCPSTGLGLG 2378

Query: 205  PQLSPGSGTPQAGTPSPSRSRD-SNSGPE-EPLLEEEEKQ 242
               +P S      + SP   R+ S+  P+ +PL  ++ KQ
Sbjct: 2379 RTTAPSSTASDFQSDSPQSHRNASHQTPQGDPLGPQDLKQ 2418



 Score = 30.0 bits (66), Expect = 4.7
 Identities = 46/213 (21%), Positives = 71/213 (33%), Gaps = 26/213 (12%)

Query: 52   TSQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRP-RPQGRSVSEPRDQHPQPSLGDSLE 110
            +SQ  G+PR  T +         SG  +  TA  P +P   S S   ++ P  +   S  
Sbjct: 3703 SSQGSGSPRPGTKTGGGSQPQPASGQLQSETATTPAKPSFPSRSPAPERLPARAQAKSCT 3762

Query: 111  SIPSLSQSPEPGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLED 170
              P      E G +G   +  P E+     + +   +   AR    G      S+    D
Sbjct: 3763 KGPR-----EAGEQGPHGSLGPKEKGESSTKRKKGQVPGPARSESVGSFGRAPSAP---D 3814

Query: 171  EEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSG 230
            + P+ P +                 Q +   VL  +  P S       PS  R  +    
Sbjct: 3815 KPPRTPRK-----------------QATPSRVLPTKPKPNSQNKPRPPPSEQRKAEPGHT 3857

Query: 231  PEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLE 263
              +  L +   Q  PL R P RG  +   +  E
Sbjct: 3858 QRKDRLGKAFPQGRPLLRPPKRGTAVHGAEPAE 3890


>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
            subunit [Homo sapiens]
          Length = 2270

 Score = 39.7 bits (91), Expect = 0.006
 Identities = 31/86 (36%), Positives = 38/86 (44%), Gaps = 3/86 (3%)

Query: 87   RPQGRSVSEPRDQHPQPSLGDSLE--SIPSLSQSPEPGR-RGDPDTAPPSERPLEDLRLR 143
            R Q RS SE R Q P      SL   SIPS+S +  P R R      PP  RPL      
Sbjct: 2073 RRQSRSPSEGRSQTPNRQGTGSLSESSIPSVSDTSTPRRSRRQLPPVPPKPRPLLSYSSL 2132

Query: 144  LDHLGWVARGTGSGEDSSTSSSTPLE 169
            + H G ++      E+ S  +S  LE
Sbjct: 2133 IRHAGSISPPADGSEEGSPLTSQALE 2158


>gi|41281612 zinc finger protein 828 [Homo sapiens]
          Length = 812

 Score = 39.3 bits (90), Expect = 0.008
 Identities = 44/166 (26%), Positives = 64/166 (38%), Gaps = 28/166 (16%)

Query: 94  SEPRDQHPQ-PSLGDSLESIPSLSQSPEP-GRRGDPDTAPPSE-RPLEDLRLRLDHLGWV 150
           S P  +H + P      +SIP+LS   +  G    P++  P+   PLE  +         
Sbjct: 108 SPPLPEHQKIPCNSAEPKSIPALSMETQKLGSVLSPESPKPTPLTPLEPQK--------- 158

Query: 151 ARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDL--RLRLAQPSSPEVLTPQ-L 207
                 G   S    TPL   EP +P  + + E  + + +    +LA   SPE   P  +
Sbjct: 159 -----PGSVVSPELQTPLPSPEPSKPASVSSPEPPKSVPVCESQKLAPVPSPEPQKPAPV 213

Query: 208 SPGSGTPQAGTPSPSRSRD--------SNSGPEEPLLEEEEKQWGP 245
           SP S       P P +           S S PE P+L    + WGP
Sbjct: 214 SPESVKATLSNPKPQKQSHFPETLGPPSASSPESPVLAASPEPWGP 259


>gi|157785645 SPEG complex locus [Homo sapiens]
          Length = 3267

 Score = 38.9 bits (89), Expect = 0.010
 Identities = 33/145 (22%), Positives = 52/145 (35%), Gaps = 10/145 (6%)

Query: 96   PRDQHPQPSLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTG 155
            P D       G  LES+   ++ P   R    + AP  + PLE+  L+       ++G  
Sbjct: 2079 PEDGKVSGLRGPLLESLGGRARDPRMARAASSEAAPHHQPPLENRGLQKSSS--FSQGEA 2136

Query: 156  SGEDSSTSSSTPLE--------DEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQL 207
                    +  PLE            + P+     EA      R    +PS+P+   P  
Sbjct: 2137 EPRGRHRRAGAPLEIPVARLGARRLQESPSLSALSEAQPSSPARPSAPKPSTPKSAEPSA 2196

Query: 208  SPGSGTPQAGTPSPSRSRDSNSGPE 232
            +  S  PQ   P P++ +     PE
Sbjct: 2197 TTPSDAPQPPAPQPAQDKAPEPRPE 2221



 Score = 36.2 bits (82), Expect = 0.066
 Identities = 44/171 (25%), Positives = 59/171 (34%), Gaps = 32/171 (18%)

Query: 91  RSVSEPRDQHPQPSLGDSLESIPSLSQSPEPGR---RGDPDTAPPSERPLEDLRLRLDHL 147
           R+VS    Q P PS  +            EPGR   RG      P E P +++R R    
Sbjct: 546 RAVSPAAAQPPSPSSAEK--------PGDEPGRPRSRGPAGRTEPGEGPQQEVRRR---- 593

Query: 148 GWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQL 207
                     +   T S    E   P  P   +  EA  +     +   P+      P  
Sbjct: 594 ---------DQFPLTRSRAIQECRSPVPPPAADPPEARTKAPPGRKREPPAQAVRFLPWA 644

Query: 208 SPGSGTPQAGTPSPSRSRDSNSGPE-EPLLE---EEEKQWGPLEREPVRGQ 254
           +PG      G   P     + +GPE E  L    EE+  WGP +R   R Q
Sbjct: 645 TPGL----EGAAVPQTLEKNRAGPEAEKRLRRGPEEDGPWGPWDRRGARSQ 691



 Score = 30.0 bits (66), Expect = 4.7
 Identities = 27/90 (30%), Positives = 36/90 (40%), Gaps = 12/90 (13%)

Query: 193  RLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEEKQWGPLEREPVR 252
            R   P SP  L P L+P + TP + T SPS    S   P    L   +    P +  P R
Sbjct: 2793 RARPPDSPTSLAPPLAPAAPTPPSVTVSPS----SPPTPPSQALSSLKAVGPPPQTPPRR 2848

Query: 253  GQCLDSTDQLEFTV--------EPRLLVAD 274
             + L +    E T+        EP+  V D
Sbjct: 2849 HRGLQAARPAEPTLPSTHVTPSEPKPFVLD 2878


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.133    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,458,128
Number of Sequences: 37866
Number of extensions: 1182507
Number of successful extensions: 6720
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 375
Number of HSP's that attempted gapping in prelim test: 6123
Number of HSP's gapped (non-prelim): 939
length of query: 472
length of database: 18,247,518
effective HSP length: 106
effective length of query: 366
effective length of database: 14,233,722
effective search space: 5209542252
effective search space used: 5209542252
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.