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Search of human proteins with 45580688
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45580688 complement component 7 precursor [Homo sapiens]
(843 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45580688 complement component 7 precursor [Homo sapiens] 1791 0.0
gi|189242612 complement component 6 precursor [Homo sapiens] 454 e-127
gi|169636415 complement component 6 precursor [Homo sapiens] 454 e-127
gi|4557389 complement component 8, alpha polypeptide precursor [... 274 3e-73
gi|4557391 complement component 8, beta polypeptide preproprotei... 245 1e-64
gi|4502511 complement component 9 precursor [Homo sapiens] 216 9e-56
gi|148886654 polydom [Homo sapiens] 81 5e-15
gi|42544177 complement component (3d/Epstein Barr virus) recepto... 75 3e-13
gi|54792123 complement component (3d/Epstein Barr virus) recepto... 75 3e-13
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 73 1e-12
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 73 1e-12
gi|147904700 semaphorin 5A [Homo sapiens] 67 5e-11
gi|62739186 complement factor H isoform a precursor [Homo sapiens] 63 1e-09
gi|133908621 perforin 1 precursor [Homo sapiens] 62 3e-09
gi|40254808 perforin 1 precursor [Homo sapiens] 62 3e-09
gi|4502503 complement component 4 binding protein, alpha chain p... 60 8e-09
gi|118572606 hemicentin 1 [Homo sapiens] 60 8e-09
gi|40317626 thrombospondin 1 precursor [Homo sapiens] 60 1e-08
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 59 1e-08
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 59 1e-08
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 59 1e-08
gi|32261318 unc-5 homolog B [Homo sapiens] 59 2e-08
gi|40317628 thrombospondin 2 precursor [Homo sapiens] 59 2e-08
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 58 3e-08
gi|134031945 SCO-spondin [Homo sapiens] 58 4e-08
gi|32261332 seizure related 6 homolog (mouse)-like precursor [Ho... 57 5e-08
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 57 5e-08
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 57 7e-08
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 57 7e-08
gi|62739188 complement factor H isoform b precursor [Homo sapiens] 57 9e-08
>gi|45580688 complement component 7 precursor [Homo sapiens]
Length = 843
Score = 1791 bits (4638), Expect = 0.0
Identities = 843/843 (100%), Positives = 843/843 (100%)
Query: 1 MKVISLFILVGFIGEFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGG 60
MKVISLFILVGFIGEFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGG
Sbjct: 1 MKVISLFILVGFIGEFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGG 60
Query: 61 QPCVGNAFETQSCEPTRGCPTEEGCGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCE 120
QPCVGNAFETQSCEPTRGCPTEEGCGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCE
Sbjct: 61 QPCVGNAFETQSCEPTRGCPTEEGCGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCE 120
Query: 121 DSERRPSCDIDKPPPNIELTGNGYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLS 180
DSERRPSCDIDKPPPNIELTGNGYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLS
Sbjct: 121 DSERRPSCDIDKPPPNIELTGNGYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLS 180
Query: 181 GNVLSYTFQVKINNDFNYEFYNSTWSYVKHTSTEHTSSSRKRSFFRSSSSSSRSYTSHTN 240
GNVLSYTFQVKINNDFNYEFYNSTWSYVKHTSTEHTSSSRKRSFFRSSSSSSRSYTSHTN
Sbjct: 181 GNVLSYTFQVKINNDFNYEFYNSTWSYVKHTSTEHTSSSRKRSFFRSSSSSSRSYTSHTN 240
Query: 241 EIHKGKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYG 300
EIHKGKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYG
Sbjct: 241 EIHKGKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYG 300
Query: 301 THYLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKCKSSGWHFVVKFSSHGCKELENAL 360
THYLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKCKSSGWHFVVKFSSHGCKELENAL
Sbjct: 301 THYLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKCKSSGWHFVVKFSSHGCKELENAL 360
Query: 361 KAASGTQNNVLRGEPFIRGGGAGFISGLSYLELDNPAGNKRRYSAWAESVTNLPQVIKQK 420
KAASGTQNNVLRGEPFIRGGGAGFISGLSYLELDNPAGNKRRYSAWAESVTNLPQVIKQK
Sbjct: 361 KAASGTQNNVLRGEPFIRGGGAGFISGLSYLELDNPAGNKRRYSAWAESVTNLPQVIKQK 420
Query: 421 LTPLYELVKEVPCASVKKLYLKWALEEYLDEFDPCHCRPCQNGGLATVEGTHCLCHCKPY 480
LTPLYELVKEVPCASVKKLYLKWALEEYLDEFDPCHCRPCQNGGLATVEGTHCLCHCKPY
Sbjct: 421 LTPLYELVKEVPCASVKKLYLKWALEEYLDEFDPCHCRPCQNGGLATVEGTHCLCHCKPY 480
Query: 481 TFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTRSRECNNPPPSGGGRSCVGETT 540
TFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTRSRECNNPPPSGGGRSCVGETT
Sbjct: 481 TFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTRSRECNNPPPSGGGRSCVGETT 540
Query: 541 ESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCN 600
ESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCN
Sbjct: 541 ESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCN 600
Query: 601 EGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCS 660
EGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCS
Sbjct: 601 EGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCS 660
Query: 661 GGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYE 720
GGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYE
Sbjct: 661 GGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYE 720
Query: 721 CGPSLDVCAQDERSKRILPLTVCKMHVLHCQGRNYTLTGRDSCTLPASAEKACGACPLWG 780
CGPSLDVCAQDERSKRILPLTVCKMHVLHCQGRNYTLTGRDSCTLPASAEKACGACPLWG
Sbjct: 721 CGPSLDVCAQDERSKRILPLTVCKMHVLHCQGRNYTLTGRDSCTLPASAEKACGACPLWG 780
Query: 781 KCDAESSKCVCREASECEEEGFSICVEVNGKEQTMSECEAGALRCRGQSISVTSIRPCAA 840
KCDAESSKCVCREASECEEEGFSICVEVNGKEQTMSECEAGALRCRGQSISVTSIRPCAA
Sbjct: 781 KCDAESSKCVCREASECEEEGFSICVEVNGKEQTMSECEAGALRCRGQSISVTSIRPCAA 840
Query: 841 ETQ 843
ETQ
Sbjct: 841 ETQ 843
>gi|189242612 complement component 6 precursor [Homo sapiens]
Length = 934
Score = 454 bits (1168), Expect = e-127
Identities = 281/871 (32%), Positives = 432/871 (49%), Gaps = 70/871 (8%)
Query: 25 PVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPTRGCPTEEG 84
P+NC + PWS+C+ C + Q++ RSV Q+GGQPC Q C P++ C EE
Sbjct: 79 PINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEA 138
Query: 85 -CGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCEDSERRPSCDID-KPPPNIELTGN 142
C +FRC SG+CI++ L CNG++DC D++DE C + C P P+++L GN
Sbjct: 139 DCKNKFRCDSGRCIARKLECNGENDCG-DNSDERDC--GRTKAVCTRKYNPIPSVQLMGN 195
Query: 143 GYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLSGNVLSYTFQVKI-NNDFNYEFY 201
G++ L G+ R V++ GG C+ V S + YR+ N+ + F+V+ +D +FY
Sbjct: 196 GFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFY 255
Query: 202 NSTWSYVKHTSTEHTSSSRKRSFFRSSS--SSSRSYTSHTNEIHKG-------KSYQLLV 252
S + + + + SS+ S F SS RS + N K K +
Sbjct: 256 KDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSENINHNSAFKQAIQASHKKDSSFIR 315
Query: 253 VENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYGTHYLQSGSLGGE 312
+ ++V F + L L++ F K L+HLP Y+ + Y R+ D +GTHY SGSLGG
Sbjct: 316 IHKVMKVLNFTTKAKD-LHLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGV 374
Query: 313 YRVLFYVDSEKLKQNDFNSVEEKKCKSSGWHFVVKFSS-----HGCKELENALKAASGTQ 367
Y +L+ SE+LK + E K C V F+ H C + + K
Sbjct: 375 YDLLYQFSSEELKNSGLTEEEAKHCVRIETKKRVLFAKKTKVEHRCTTNKLSEKHEGSFI 434
Query: 368 NNVLRGEPFIRGGGAGFISGLSYLELDNPAGNKRRYSAWAESVTNLPQVIKQKLTPLYEL 427
+ IRGG + + + L++ E + ++ +S W ESV P VI +L P+ +L
Sbjct: 435 QGAEKSISLIRGGRSEYGAALAW-EKGSSGLEEKTFSEWLESVKENPAVIDFELAPIVDL 493
Query: 428 VKEVPCASVKKLYLKWALEEYLDEFDPCHCRPCQNGGLATVEGTHCLCHCKPYTFGAACE 487
V+ +PCA K+ L+ AL+EY +FDPC C PC N G T+ GT CLC C+ T+G CE
Sbjct: 494 VRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECLCVCQSGTYGENCE 553
Query: 488 QGVLVGNQAGGVDGGWSCWSSWSPC-VQGKKTRSRECNNPPPSGGGRSCVGETTESTQC- 545
+ ++ VDG W CWSSWS C K++R+RECNNP P GG+ C GE + C
Sbjct: 554 K-QSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCT 612
Query: 546 -------------EDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVG 592
+DEE++ + L E + CP P ++GF+++E ++ VG
Sbjct: 613 FSIMENNGQPCINDDEEMKEVDLPE-------IEADSGCPQPVPPENGFIRNEKQLYLVG 665
Query: 593 KNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVG 652
++V +C G+ +G RC D W G++ CQ+ C+ PV+ + + P + Y +G
Sbjct: 666 EDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIG 725
Query: 653 EKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSR 712
E + ++C G + GPS + C + W+P + N+ +K+ LT+ CQ +K S
Sbjct: 726 ESIELTCPKGFVVAGPSRYTCQGN-SWTPPISNSLTCEKDT-LTKLKGHCQLGQKQSGSE 783
Query: 713 CVCKMPYE-CG-PSLDVCAQDERSKRILPLTVCK-----------MHVLH---CQGRNYT 756
C+C P E C S D+C D S CK +H LH CQ
Sbjct: 784 CICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDGRQL 843
Query: 757 LTGRDSCTLPASAEK--ACG--ACPLWGKCDAESSKCVCREASECEEEGFSI-CVEVNG- 810
G + L +++ K +CG C W KC A +SKCVC +C + G + CV++
Sbjct: 844 EWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKMGSS 903
Query: 811 -KEQTMSECEAGALRCRGQSISVTSIRPCAA 840
E+T++ CE G +RC + + + C A
Sbjct: 904 TSEKTLNICEVGTIRCANRKMEILHPGKCLA 934
Score = 33.9 bits (76), Expect = 0.65
Identities = 18/59 (30%), Positives = 26/59 (44%)
Query: 15 EFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSC 73
E QS S+ V+ QW ++ WS C+ K R Q GG+ C G + + C
Sbjct: 553 EKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDC 611
>gi|169636415 complement component 6 precursor [Homo sapiens]
Length = 934
Score = 454 bits (1168), Expect = e-127
Identities = 281/871 (32%), Positives = 432/871 (49%), Gaps = 70/871 (8%)
Query: 25 PVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPTRGCPTEEG 84
P+NC + PWS+C+ C + Q++ RSV Q+GGQPC Q C P++ C EE
Sbjct: 79 PINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEA 138
Query: 85 -CGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCEDSERRPSCDID-KPPPNIELTGN 142
C +FRC SG+CI++ L CNG++DC D++DE C + C P P+++L GN
Sbjct: 139 DCKNKFRCDSGRCIARKLECNGENDCG-DNSDERDC--GRTKAVCTRKYNPIPSVQLMGN 195
Query: 143 GYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLSGNVLSYTFQVKI-NNDFNYEFY 201
G++ L G+ R V++ GG C+ V S + YR+ N+ + F+V+ +D +FY
Sbjct: 196 GFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFY 255
Query: 202 NSTWSYVKHTSTEHTSSSRKRSFFRSSS--SSSRSYTSHTNEIHKG-------KSYQLLV 252
S + + + + SS+ S F SS RS + N K K +
Sbjct: 256 KDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSENINHNSAFKQAIQASHKKDSSFIR 315
Query: 253 VENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYGTHYLQSGSLGGE 312
+ ++V F + L L++ F K L+HLP Y+ + Y R+ D +GTHY SGSLGG
Sbjct: 316 IHKVMKVLNFTTKAKD-LHLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGV 374
Query: 313 YRVLFYVDSEKLKQNDFNSVEEKKCKSSGWHFVVKFSS-----HGCKELENALKAASGTQ 367
Y +L+ SE+LK + E K C V F+ H C + + K
Sbjct: 375 YDLLYQFSSEELKNSGLTEEEAKHCVRIETKKRVLFAKKTKVEHRCTTNKLSEKHEGSFI 434
Query: 368 NNVLRGEPFIRGGGAGFISGLSYLELDNPAGNKRRYSAWAESVTNLPQVIKQKLTPLYEL 427
+ IRGG + + + L++ E + ++ +S W ESV P VI +L P+ +L
Sbjct: 435 QGAEKSISLIRGGRSEYGAALAW-EKGSSGLEEKTFSEWLESVKENPAVIDFELAPIVDL 493
Query: 428 VKEVPCASVKKLYLKWALEEYLDEFDPCHCRPCQNGGLATVEGTHCLCHCKPYTFGAACE 487
V+ +PCA K+ L+ AL+EY +FDPC C PC N G T+ GT CLC C+ T+G CE
Sbjct: 494 VRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECLCVCQSGTYGENCE 553
Query: 488 QGVLVGNQAGGVDGGWSCWSSWSPC-VQGKKTRSRECNNPPPSGGGRSCVGETTESTQC- 545
+ ++ VDG W CWSSWS C K++R+RECNNP P GG+ C GE + C
Sbjct: 554 K-QSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCT 612
Query: 546 -------------EDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVG 592
+DEE++ + L E + CP P ++GF+++E ++ VG
Sbjct: 613 FSIMENNGQPCINDDEEMKEVDLPE-------IEADSGCPQPVPPENGFIRNEKQLYLVG 665
Query: 593 KNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVG 652
++V +C G+ +G RC D W G++ CQ+ C+ PV+ + + P + Y +G
Sbjct: 666 EDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIG 725
Query: 653 EKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSR 712
E + ++C G + GPS + C + W+P + N+ +K+ LT+ CQ +K S
Sbjct: 726 ESIELTCPKGFVVAGPSRYTCQGN-SWTPPISNSLTCEKDT-LTKLKGHCQLGQKQSGSE 783
Query: 713 CVCKMPYE-CG-PSLDVCAQDERSKRILPLTVCK-----------MHVLH---CQGRNYT 756
C+C P E C S D+C D S CK +H LH CQ
Sbjct: 784 CICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDGRQL 843
Query: 757 LTGRDSCTLPASAEK--ACG--ACPLWGKCDAESSKCVCREASECEEEGFSI-CVEVNG- 810
G + L +++ K +CG C W KC A +SKCVC +C + G + CV++
Sbjct: 844 EWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKMGSS 903
Query: 811 -KEQTMSECEAGALRCRGQSISVTSIRPCAA 840
E+T++ CE G +RC + + + C A
Sbjct: 904 TSEKTLNICEVGTIRCANRKMEILHPGKCLA 934
Score = 33.9 bits (76), Expect = 0.65
Identities = 18/59 (30%), Positives = 26/59 (44%)
Query: 15 EFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSC 73
E QS S+ V+ QW ++ WS C+ K R Q GG+ C G + + C
Sbjct: 553 EKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDC 611
>gi|4557389 complement component 8, alpha polypeptide precursor
[Homo sapiens]
Length = 584
Score = 274 bits (700), Expect = 3e-73
Identities = 170/565 (30%), Positives = 264/565 (46%), Gaps = 50/565 (8%)
Query: 20 SSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPTRGC 79
++ + V CQ ++ W++C C + R RS+ ++GG C G+ ++ SC + C
Sbjct: 31 AATPAAVTCQLSNWSEWTDCFPCQDKKYRHRSLLQPNKFGGTICSGDIWDQASCSSSTTC 90
Query: 80 PTEEGCGERFRCF-SGQCISKSLVCNGDSDCDEDSADEDRCEDSER-RPSCDIDKPPPNI 137
+ CG+ F+C +G+C+ + LVCNGD DC D +DED CED C +P P
Sbjct: 91 VRQAQCGQDFQCKETGRCLKRHLVCNGDQDC-LDGSDEDDCEDVRAIDEDCSQYEPIPGS 149
Query: 138 ELTGNGYNELTGQFRNRVINTKSFGGQCRKVFSG-----------------DGKDFYRLS 180
+ GYN LT + V + +GGQC V++G D + ++R
Sbjct: 150 QKAALGYNILTQEDAQSVYDASYYGGQCETVYNGEWRELRYDSTCERLYYGDDEKYFRKP 209
Query: 181 GNVLSYTFQVKINNDFNYEFYNSTWSYVKHTSTEHTSSSRKRSFFRSSSS--------SS 232
N L Y F+ + + EFY++ + + + S + S S
Sbjct: 210 YNFLKYHFEALADTGISSEFYDNANDLLSKVKKDKSDSFGVTIGIGPAGSPLLVGVGVSH 269
Query: 233 RSYTSHTNEIHK--GKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYS 290
TS NE++K K + + V+ A F + + L E + L LP Y+Y
Sbjct: 270 SQDTSFLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIM-LDEGMLQSLMELPDQYNYG 328
Query: 291 AYRRLIDQYGTHYLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKC--KSSGWHFVVKF 348
Y + I+ YGTHY+ SGS+GG Y + +D K++ S + C S G + K
Sbjct: 329 MYAKFINDYGTHYITSGSMGGIYEYILVIDKAKMESLGITSRDITTCFGGSLGIQYEDKI 388
Query: 349 SSHGCKELENALKAASGTQNNVLRGEPF------IRGGGAGFISGLSYLELDNPAGNKRR 402
+ G ++ K G + +RGG +G+ GL+ +
Sbjct: 389 NVGGGLSGDHCKKFGGGKTERARKAMAVEDIISRVRGGSSGWSGGLAQNR------STIT 442
Query: 403 YSAWAESVTNLPQVIKQKLTPLYELVKEVPCASV--KKLYLKWALEEYLDEFDPCHCRPC 460
Y +W S+ P VI ++ P++E+++ + K+ L+ AL++YL EF+ C C PC
Sbjct: 443 YRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCGPC 502
Query: 461 QNGGLATVEGTHCLCHCKPYTFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTRS 520
N G+ +EGT C C C+ + GAACEQ G +A DG WSCWSSWS C G + R
Sbjct: 503 FNNGVPILEGTSCRCQCRLGSLGAACEQTQTEGAKA---DGSWSCWSSWSVCRAGIQERR 559
Query: 521 RECNNPPPSGGGRSCVGETTESTQC 545
REC+NP P GG SC G ++ C
Sbjct: 560 RECDNPAPQNGGASCPGRKVQTQAC 584
>gi|4557391 complement component 8, beta polypeptide preproprotein
[Homo sapiens]
Length = 591
Score = 245 bits (626), Expect = 1e-64
Identities = 164/554 (29%), Positives = 256/554 (46%), Gaps = 38/554 (6%)
Query: 15 EFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCE 74
+ +S P++C+ ++ W+ C+ C K + R + Q+ G+PC + E + C
Sbjct: 52 QMRSVDVTLMPIDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSDKEVEDCV 111
Query: 75 PTRGCPTEEGCGERFRCF-SGQCISKSLVCNGDSDCDEDSADEDRCEDSERRPSCDIDKP 133
R C ++ C E F C +G+C+++ L+CNGD+DC D +DE C ++ ++D+
Sbjct: 112 TNRPCGSQVRC-EGFVCAQTGRCVNRRLLCNGDNDCG-DQSDEANCRRIYKKCQHEMDQY 169
Query: 134 PPNIELTGNGYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLSGNVLSYTFQVKIN 193
I +G N T F V++ + + G C + + + +R NV SYT Q +
Sbjct: 170 W-GIGSLASGINLFTNSFEGPVLDHRYYAGGCSPHYILNTR--FRKPYNVESYTPQTQGK 226
Query: 194 NDFNYEFYNSTWSYVKHTSTEHTSSSRKRSF-----------FRSSSSSSRSYTSHTNEI 242
+F + Y S +S + TE +S SF S S + Y T
Sbjct: 227 YEFILKEYES-YSDFERNVTEKMASKSGFSFGFKIPGIFELGISSQSDRGKHYIRRTKRF 285
Query: 243 HKGKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYGTH 302
KS L + +EVA + P L L F + + LP Y Y YR L +GTH
Sbjct: 286 SHTKSV-FLHARSDLEVAHY-KLKPRSLMLHYEFLQRVKRLPLEYSYGEYRDLFRDFGTH 343
Query: 303 YLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKCKSSGW---------HFVVKFSSHGC 353
Y+ LGG Y ++ E +++ D+ C + + + + S C
Sbjct: 344 YITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYVSLGVSVGKC 403
Query: 354 KELENALKAASGTQNNVLRGEPFIRGGGAGFISGLSYLELDNPAGNKRRYSAWAESVTNL 413
+ + N +K + V +RGG + I+ L+Y EL P + + W ++V
Sbjct: 404 RGILNEIKDRNKRDTMVEDLVVLVRGGASEHITTLAYQEL--PTADLMQ--EWGDAVQYN 459
Query: 414 PQVIKQKLTPLYELVKEVPCA--SVKKLYLKWALEEYLDEFDPCHCRPCQNGGLATVEGT 471
P +IK K+ PLYELV A S + +K ALEE+ E CHC PCQ G+ ++G+
Sbjct: 460 PAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPCQGNGVPVLKGS 519
Query: 472 HCLCHCKPYTFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTRSRECNNPPPSGG 531
C C C + G ACE +DG W+CWS+WS C +KTR R+CNNPPP G
Sbjct: 520 RCDCICPVGSQGLACEVSYRKNTP---IDGKWNCWSNWSSCSGRRKTRQRQCNNPPPQNG 576
Query: 532 GRSCVGETTESTQC 545
G C G +E+ C
Sbjct: 577 GSPCSGPASETLDC 590
>gi|4502511 complement component 9 precursor [Homo sapiens]
Length = 559
Score = 216 bits (549), Expect = 9e-56
Identities = 152/519 (29%), Positives = 235/519 (45%), Gaps = 54/519 (10%)
Query: 15 EFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCE 74
E S ++S ++C+ ++ WS+C+ C + R RS+ V+GQ+ G+ C + + C
Sbjct: 30 ELTESSGSASHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCV 89
Query: 75 PTRGC-PTEEGCGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCEDSERRPSCDIDKP 133
PT C E+ CG F+C +G+CI L CNGD+DC D +DED CE SE RP C D+
Sbjct: 90 PTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCG-DFSDEDDCE-SEPRPPCR-DRV 146
Query: 134 PPNIEL---TGNGYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLSGNVLSYTFQV 190
EL G G N L + + + + G C + G+ +YR NV S ++
Sbjct: 147 VEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYET 206
Query: 191 KINNDFNYEFYNSTWSYVKHTSTEHTS-----------------------------SSRK 221
K +F E Y K E TS S
Sbjct: 207 KGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFTPTETNKAEQCCEETASSISLHG 266
Query: 222 RSFFRSSSSSSRSYTSHTNEIHKGKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELS 281
+ FR S S + +Y + K K L V+ + + +F+ N + + L F ++
Sbjct: 267 KGSFRFSYSKNETYQLFLSYSSK-KEKMFLHVKGEIHLGRFVMRNRDVV-LTTTFVDDIK 324
Query: 282 HLPSLYDYSAYRRLIDQYGTHYLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKCKSSG 341
LP+ Y+ Y ++ YGTHY SGSLGG Y +++ +D +K+ + K+C G
Sbjct: 325 ALPTTYEKGEYFAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRC--LG 382
Query: 342 WHFVV-----------KFSSHGCKELENALKAASGTQNNVLRGEPFIRGGGAGFISGLSY 390
+H V +F+ C + ++N + IRGG + L
Sbjct: 383 YHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELKE 442
Query: 391 LELDNPAGNKRRYSAWAESVTNLPQVIKQKLTPLYELVK-EVPCASVKKLYLKWALEEYL 449
L + + WA S+ + P +I QKL+P+Y LV ++ A +KK L+ A+E+Y+
Sbjct: 443 KLLRGTVIDVTDFVNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLERAIEDYI 502
Query: 450 DEFDPCHCRPCQNGGLATVEGTHCLCHCKPYTF-GAACE 487
+EF C CQNGG + CLC C P+ F G ACE
Sbjct: 503 NEFSVRKCHTCQNGGTVILMDGKCLCAC-PFKFEGIACE 540
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 80.9 bits (198), Expect = 5e-15
Identities = 49/166 (29%), Positives = 78/166 (46%), Gaps = 18/166 (10%)
Query: 534 SCVG----ETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMF 589
SCVG +T C+ + L P C P+ CP P + +G + +G +
Sbjct: 2407 SCVGGFFLRGNSTTLCQPDGTWSSPL--PECVPVE------CPQPEEIPNGIIDVQGLAY 2458
Query: 590 PVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLP-VLMDGIQSHPQKPF 648
+YTC G+ L+GN CGE+ WL G+ C+ I C+ P +++G S+ +
Sbjct: 2459 L--STALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHY 2516
Query: 649 YTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENP 694
G+ VT SC+ G LEGPSA C + W + + + ++P
Sbjct: 2517 ---GQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSP 2559
Score = 71.6 bits (174), Expect = 3e-12
Identities = 42/133 (31%), Positives = 57/133 (42%), Gaps = 16/133 (12%)
Query: 570 FCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKI 629
FC PPA+KD + G F V YTC EGY+L G C D +W + C +
Sbjct: 1962 FCGEPPAIKDAVIT--GNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAV 2019
Query: 630 ACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCV 689
+C P ++D + P+ G+ CS G SL S LC + KW P
Sbjct: 2020 SCDEPPIVD--HASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQGKWVP-------- 2069
Query: 690 QKENPLTQAVPKC 702
P Q +P+C
Sbjct: 2070 ----PEGQDMPRC 2078
Score = 66.2 bits (160), Expect = 1e-10
Identities = 80/299 (26%), Positives = 112/299 (37%), Gaps = 59/299 (19%)
Query: 456 HC---RPCQNGGLATVEGTHCLCHCKPYTFGAACEQGVLVGNQAGG------VDGGWSCW 506
HC +P +NG VEG Y++GA G Q G + GWS
Sbjct: 2555 HCDSPQPIENG---FVEGAD-------YSYGAIIIYSCFPGFQVAGHAMQTCEESGWS-- 2602
Query: 507 SSWSPCVQGKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHC-FPLSL 565
SS C+ +C PP G + + +++++ + + PH + L
Sbjct: 2603 SSIPTCMP------IDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGA 2656
Query: 566 VPT--EFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGE 623
V E PA + F G V YTCN GY L+GNPV C ED W
Sbjct: 2657 VAKTWENTKESPAT-------HSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSA 2709
Query: 624 MHCQKIACVLPVLMDGIQSHPQKPFY-----TVGEKVTVSCSGGMSLEGPSAFLCGSSLK 678
C I C LP + P+ F ++G V SC G L G LC + K
Sbjct: 2710 PSCISIECDLP-------TAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLENRK 2762
Query: 679 W---SPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYECGPSLDVCAQDERS 734
W SP + C +K NP+ K + L + YEC P + + R+
Sbjct: 2763 WSGASPRCEAISC-KKPNPVMNGSIKGSNYTYLST------LYYECDPGYVLNGTERRT 2814
Score = 64.7 bits (156), Expect = 3e-10
Identities = 41/120 (34%), Positives = 57/120 (47%), Gaps = 6/120 (5%)
Query: 562 PLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRW-L 620
PL VP + C PP +++GF++ E F VG V + CNEGY L+G+ C + +W
Sbjct: 2256 PLMCVPLD-CGKPPPIQNGFMKGEN--FEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNK 2312
Query: 621 VGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWS 680
C C P L++ K T VT SC G L+GPS C S +W+
Sbjct: 2313 KSNPKCMPAKCPEPPLLE--NQLVLKELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWN 2370
Score = 60.5 bits (145), Expect = 6e-09
Identities = 52/179 (29%), Positives = 72/179 (40%), Gaps = 16/179 (8%)
Query: 558 PHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDL 617
P C P CP PP L++ V E T VG V ++C EG+ L G V +C
Sbjct: 2316 PKCMPAK------CPEPPLLENQLVLKELTT-EVGV-VTFSCKEGHVLQGPSVLKCLPSQ 2367
Query: 618 RWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSL 677
+W C+ + C P L+ P + G V SC GG L G S LC
Sbjct: 2368 QWNDSFPVCKIVLCTPPPLISFGVPIPSSALH-FGSTVKYSCVGGFFLRGNSTTLCQPDG 2426
Query: 678 KWSPEMKNARCVQKENPLTQAVPK----CQRWEKLQNSRCVCKMPYE-CGPSLDVCAQD 731
WS + CV E P + +P Q L + CK +E G + +C ++
Sbjct: 2427 TWSSPL--PECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGEN 2483
Score = 59.3 bits (142), Expect = 1e-08
Identities = 58/244 (23%), Positives = 91/244 (37%), Gaps = 30/244 (12%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIA 630
C +P ++G G ++ VG V ++C EGY L+G C E W +C+ ++
Sbjct: 1789 CKAPGNPENG--HSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVS 1846
Query: 631 CVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWS---PEMKNAR 687
C P + + ++ +T G KVT C+ G +L G C ++ WS P + +
Sbjct: 1847 CGKPAIPE--NGCIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVK 1904
Query: 688 CVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYEC-GPSLDVCAQDERSKRILPLTVCKMH 746
C EN + L + C Y GPS+ C R P H
Sbjct: 1905 CSSPEN-INNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPP----ACH 1959
Query: 747 VLHC-----------QGRNYTL------TGRDSCTLPASAEKACGACPLWGKCDAESSKC 789
++ C G N+T T ++ TL C A W + D +
Sbjct: 1960 LVFCGEPPAIKDAVITGNNFTFRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAV 2019
Query: 790 VCRE 793
C E
Sbjct: 2020 SCDE 2023
Score = 57.8 bits (138), Expect = 4e-08
Identities = 40/140 (28%), Positives = 60/140 (42%), Gaps = 11/140 (7%)
Query: 557 EPHC-------FPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNP 609
E HC P+ L CP P + + + E + V +NV C EG+ L G+
Sbjct: 3336 EAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFY-VDQNVSIKCREGFLLQGHG 3394
Query: 610 VARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPS 669
+ C D W C+KI+C P ++ + + Y G+ +T SC G LEG
Sbjct: 3395 IITCNPDETWTQTSAKCEKISCGPPAHVE--NAIARGVHYQYGDMITYSCYSGYMLEGFL 3452
Query: 670 AFLCGSSLKW-SPEMKNARC 688
+C + W SP + A C
Sbjct: 3453 RSVCLENGTWTSPPICRAVC 3472
Score = 57.4 bits (137), Expect = 5e-08
Identities = 54/193 (27%), Positives = 76/193 (39%), Gaps = 19/193 (9%)
Query: 508 SWSPCVQGKKTRSRECNNPP-PSGG---GRSCVGETTESTQCEDE-ELEHLRLLEPHCFP 562
+W P + C P P G G E+T QCE ELE R E C
Sbjct: 3226 TWEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNR--ERVCQE 3283
Query: 563 -------LSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGE 615
+++ C +P +G E G NVVY+CN GYSL G A C E
Sbjct: 3284 NRQWSGGVAICKETRCETPLEFLNGKADIENRT--TGPNVVYSCNRGYSLEGPSEAHCTE 3341
Query: 616 DLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGS 675
+ W C+ C +P ++ +K FY V + V++ C G L+G C
Sbjct: 3342 NGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFY-VDQNVSIKCREGFLLQGHGIITCNP 3400
Query: 676 SLKWSPEMKNARC 688
W+ +A+C
Sbjct: 3401 DETWT--QTSAKC 3411
Score = 55.8 bits (133), Expect = 2e-07
Identities = 32/90 (35%), Positives = 43/90 (47%), Gaps = 4/90 (4%)
Query: 592 GKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIAC-VLPVLMDGIQSHPQKPFYT 650
G V C+ G+ L+GNPV C +W HC++I+C V P L +G H FY
Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGF--HSADDFY- 1707
Query: 651 VGEKVTVSCSGGMSLEGPSAFLCGSSLKWS 680
G VT C+ G L G S C + W+
Sbjct: 1708 AGSTVTYQCNNGYYLLGDSRMFCTDNGSWN 1737
Score = 54.7 bits (130), Expect = 4e-07
Identities = 54/216 (25%), Positives = 76/216 (35%), Gaps = 51/216 (23%)
Query: 558 PHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDL 617
PHC +S C PP L++GF + F G V Y CN GY L+G+ C ++
Sbjct: 1683 PHCERIS------CGVPPPLENGFHSADD--FYAGSTVTYQCNNGYYLLGDSRMFCTDNG 1734
Query: 618 RWLVGEMHCQKI------------------------ACVLPVLMDG-------------- 639
W C + +CV P DG
Sbjct: 1735 SWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGN 1794
Query: 640 -IQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQA 698
H YTVG +VT SC G L G + C S +W+ + + V P A
Sbjct: 1795 PENGHSSGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKP---A 1851
Query: 699 VPKCQRWEKLQNSRCVCKMPYECGPSLDVCAQDERS 734
+P+ E+L + K+ Y C + E S
Sbjct: 1852 IPENGCIEELAFT-FGSKVTYRCNKGYTLAGDKESS 1886
Score = 53.9 bits (128), Expect = 6e-07
Identities = 53/186 (28%), Positives = 69/186 (37%), Gaps = 29/186 (15%)
Query: 522 ECNNPPPSGGGRSCVGETT-----ESTQCEDEELEHLRL-----------LEPHCFPLSL 565
+C++PP S G+ E T E T E LE R P C P+
Sbjct: 2832 DCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVR- 2890
Query: 566 VPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMH 625
C +PP L +G EG + K V + C+EGY L G P C D W
Sbjct: 2891 -----CATPPQLANGVT--EGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPL 2943
Query: 626 CQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKW---SPE 682
C+ + C P D P + G + C G L G S+ C S+ W SP
Sbjct: 2944 CKPVNCGPP--EDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPS 3001
Query: 683 MKNARC 688
RC
Sbjct: 3002 CLPCRC 3007
Score = 51.2 bits (121), Expect = 4e-06
Identities = 67/284 (23%), Positives = 103/284 (36%), Gaps = 33/284 (11%)
Query: 558 PHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDL 617
P C P S P ++ G V GT F GK C +G+ L+G C D
Sbjct: 3000 PSCLPCRC-------STPVIEYGTVN--GTDFDCGKAARIQCFKGFKLLGLSEITCEADG 3050
Query: 618 RWLVGEMHCQKIAC-VLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSS 676
+W G HC+ +C LP++ + S V +T SC G ++G S +C
Sbjct: 3051 QWSSGFPHCEHTSCGSLPMIPNAFISETSSWKENV---ITYSCRSGYVIQGSSDLICTEK 3107
Query: 677 LKWS---PEMKNARCVQKENPLTQ-AVPKCQRWEKLQNSRCVCKMPYECGPSLDVCAQDE 732
WS P + C + A + +E RC+ + C +D
Sbjct: 3108 GVWSQPYPVCEPLSCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDG 3167
Query: 733 R--------SKRILPLTVCKMHVLHCQGRNYTLTGR--DSCTLPASAEKA-CGACPLWGK 781
R S + PL H+L G ++++ + SC + E C L G
Sbjct: 3168 RWFPERISCSPKKCPLPENITHIL-VHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGT 3226
Query: 782 CDAESSKCVCREAS----ECEEEGFSICVEVNGKEQTMSECEAG 821
+ S C S E E GF + + + + +CE G
Sbjct: 3227 WEPPFSDESCSPVSCGKPESPEHGFVVGSKYTFESTIIYQCEPG 3270
Score = 50.4 bits (119), Expect = 7e-06
Identities = 38/167 (22%), Positives = 66/167 (39%), Gaps = 9/167 (5%)
Query: 558 PHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDL 617
P + +P C PP++ +G+ G+ + G V Y+CN+G+ + G + C
Sbjct: 2134 PSPMSIQCIPVR-CGEPPSIMNGYAS--GSNYSFGAMVAYSCNKGFYIKGEKKSTCEATG 2190
Query: 618 RWLVGEMHCQKIAC-VLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSS 676
+W C ++C P + +G H + +V C+ G G F+C ++
Sbjct: 2191 QWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFE--SEVRYQCNPGYKSVGSPVFVCQAN 2248
Query: 677 LKW---SPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYE 720
W SP M K P+ K + +E + C YE
Sbjct: 2249 RHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYE 2295
Score = 49.3 bits (116), Expect = 1e-05
Identities = 37/134 (27%), Positives = 51/134 (38%), Gaps = 14/134 (10%)
Query: 558 PHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDL 617
P C P++ C P L GF G F G ++ Y C GY L GN RC +
Sbjct: 2942 PLCKPVN------CGPPEDLAHGF--PNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNG 2993
Query: 618 RWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSL 677
W C C PV+ G + + G+ + C G L G S C +
Sbjct: 2994 SWSGSSPSCLPCRCSTPVIEYGTVNGTD---FDCGKAARIQCFKGFKLLGLSEITCEADG 3050
Query: 678 KWS---PEMKNARC 688
+WS P ++ C
Sbjct: 3051 QWSSGFPHCEHTSC 3064
Score = 48.5 bits (114), Expect = 3e-05
Identities = 37/148 (25%), Positives = 63/148 (42%), Gaps = 16/148 (10%)
Query: 558 PHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDL 617
P C +S C P + +G ++ G+ + + Y C+ GY L G C +D
Sbjct: 2768 PRCEAIS------CKKPNPVMNGSIK--GSNYTYLSTLYYECDPGYVLNGTERRTCQDDK 2819
Query: 618 RWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSL 677
W E C + C P + Q + YT +++ +C+ G LEG + +C ++
Sbjct: 2820 NWDEDEPICIPVDCSSPPVSANGQVRGDE--YTFQKEIEYTCNEGFLLEGARSRVCLANG 2877
Query: 678 KWS---PEMKNARCV---QKENPLTQAV 699
WS P+ RC Q N +T+ +
Sbjct: 2878 SWSGATPDCVPVRCATPPQLANGVTEGL 2905
Score = 44.3 bits (103), Expect = 5e-04
Identities = 46/188 (24%), Positives = 69/188 (36%), Gaps = 29/188 (15%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWL--VGEMHCQK 628
CP P + V G F V + V +C EGY+ G ++ C D W + C
Sbjct: 3181 CPLPENITHILVH--GDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSP 3238
Query: 629 IACVLPVLMDGIQSHPQKPF-----YTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEM 683
++C P P+ F YT + C G LEG +C + +WS +
Sbjct: 3239 VSCGKP-------ESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGV 3291
Query: 684 KNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYEC-------GPSLDVCAQDERSKR 736
+ + E PL K ++N + Y C GPS C ++
Sbjct: 3292 AICKETRCETPLEFLNGKAD----IENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSH 3347
Query: 737 ILPLTVCK 744
+PL CK
Sbjct: 3348 PVPL--CK 3353
Score = 41.2 bits (95), Expect = 0.004
Identities = 33/129 (25%), Positives = 48/129 (37%), Gaps = 8/129 (6%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIA 630
C PP + G V + G V Y+C G+ L GN C D W C +
Sbjct: 2381 CTPPPLISFG-VPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVE 2439
Query: 631 CVLP-VLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKW---SPEMKNA 686
C P + +GI + + +C G L G + LCG + W P K
Sbjct: 2440 CPQPEEIPNGIIDVQGLAYLST---ALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAI 2496
Query: 687 RCVQKENPL 695
C++ + L
Sbjct: 2497 ECLKPKEIL 2505
Score = 40.8 bits (94), Expect = 0.005
Identities = 28/128 (21%), Positives = 48/128 (37%), Gaps = 15/128 (11%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMH----- 625
C PP + + +F G Y C++GYSL N C +W+ E
Sbjct: 2021 CDEPPIVDHASPETAHRLF--GDIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRC 2078
Query: 626 ----CQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSP 681
C+K V +++ + K + G V+ C G L + C +W+P
Sbjct: 2079 IAHFCEKPPSVSYSILESVS----KAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNP 2134
Query: 682 EMKNARCV 689
+ +C+
Sbjct: 2135 SPMSIQCI 2142
Score = 38.5 bits (88), Expect = 0.026
Identities = 56/235 (23%), Positives = 78/235 (33%), Gaps = 48/235 (20%)
Query: 470 GTH-----CLCHCKPYTFG-----AACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTR 519
GTH C+C Y G AC G + G GG S S PC T
Sbjct: 297 GTHTGHFECICEKGYYGKGLQYECTACPSGTY---KPEGSPGGIS---SCIPCPDENHT- 349
Query: 520 SRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKD 579
+PP S CV + EL H CP+ ++
Sbjct: 350 -----SPPGSTSPEDCVCREGYRASGQTCELVH------------------CPALKPPEN 386
Query: 580 GFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDG 639
G+ C+ G+ L+G+ + C + W E +C+ C P L
Sbjct: 387 GYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVRTC--PHLRQP 444
Query: 640 IQSHPQKPFYTVGEKVT--VSCSGGMSLEGPSAFLCGSSLKW-SPEMKNARCVQK 691
H + K T V+C G LEG C + +W PE RCV++
Sbjct: 445 KHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPE---PRCVER 496
Score = 36.2 bits (82), Expect = 0.13
Identities = 33/128 (25%), Positives = 46/128 (35%), Gaps = 4/128 (3%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIA 630
CP K G + + C+EGY L G+ C + +W E C +
Sbjct: 438 CPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERH 497
Query: 631 CVLPVLMDGIQSHPQ---KPFYTVGEKVTVSCSGGMSLEGPSAFL-CGSSLKWSPEMKNA 686
C + + P K G VSC G L G L C +S KW+ ++ A
Sbjct: 498 CSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAA 557
Query: 687 RCVQKENP 694
C E P
Sbjct: 558 VCKDVEAP 565
>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
isoform 2 [Homo sapiens]
Length = 1033
Score = 74.7 bits (182), Expect = 3e-13
Identities = 40/120 (33%), Positives = 58/120 (48%), Gaps = 4/120 (3%)
Query: 571 CPSPPALKDG-FVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKI 629
CP PP +G F G +++Y+C++GY L+G + C + W HC+++
Sbjct: 851 CPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEV 910
Query: 630 ACVLPVLMDGIQS--HPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNAR 687
C P MDGIQ P+K Y G VT+ C G LEG C S +W+P + R
Sbjct: 911 NCSSPADMDGIQKGLEPRK-MYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCR 969
Score = 59.7 bits (143), Expect = 1e-08
Identities = 53/208 (25%), Positives = 81/208 (38%), Gaps = 23/208 (11%)
Query: 571 CPSPPALKDGFVQDEGTM-FPVGKNVVYTCNEG------YSLIGNPVARCGEDLR----W 619
CP PP + +G FP G V YTCN G +SLIG RC + + W
Sbjct: 527 CPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTW 586
Query: 620 LVGEMHCQ----KIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGS 675
C+ + C + +G + ++ Y + VT C G +L+G S C +
Sbjct: 587 SGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKA 646
Query: 676 SLKWSPEMK--NARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYE-CGPSLDVCAQDE 732
W PE+ Q Q +P R E + S C+ Y+ G + +C E
Sbjct: 647 DNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTS---CQDGYQLTGHAYQMCQDAE 703
Query: 733 RSKRILPLTVCKMHVLHCQGRNYTLTGR 760
+ +CK V+HC + G+
Sbjct: 704 NGIWFKKIPLCK--VIHCHPPPVIVNGK 729
Score = 56.6 bits (135), Expect = 9e-08
Identities = 41/181 (22%), Positives = 69/181 (38%), Gaps = 2/181 (1%)
Query: 523 CNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFV 582
C+ P G +GE+T + ++ P C LS + CP P L+ V
Sbjct: 305 CDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRC-ELSTSAVQ-CPHPQILRGRMV 362
Query: 583 QDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQS 642
+ + V++ C G++L G+ RC W C+K P +++G +
Sbjct: 363 SGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKE 422
Query: 643 HPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKC 702
+ G + SC+ G L G + C S W+P + + E Q + K
Sbjct: 423 DRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKP 482
Query: 703 Q 703
Q
Sbjct: 483 Q 483
Score = 52.4 bits (124), Expect = 2e-06
Identities = 57/230 (24%), Positives = 88/230 (38%), Gaps = 33/230 (14%)
Query: 570 FCPSPPALKDG-FVQDEGTMFPVGKNVVYTCN----EG--YSLIGNPVARCGEDLR---- 618
FCPSPP + +G + + G V YTC+ EG + LIG RC D +
Sbjct: 275 FCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGT 334
Query: 619 WLVGEMHCQ----KIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCG 674
W C+ + C P ++ G QK YT + V +C G +L+G C
Sbjct: 335 WSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCN 394
Query: 675 SSLKWSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCV-----CKMPYECGPSLDVCA 729
+ W P +A +KE QA P +K ++ V + Y C P +
Sbjct: 395 AQGTWEP---SAPVCEKE---CQAPPNILNGQK-EDRHMVRFDPGTSIKYSCNPGYVLVG 447
Query: 730 QDE---RSKRIL--PLTVCKMHVLHCQGRNYTLTGRDSCTLPASAEKACG 774
++ S+ + P+ CK+ GR + P +CG
Sbjct: 448 EESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRP-DVNSSCG 496
Score = 51.6 bits (122), Expect = 3e-06
Identities = 38/129 (29%), Positives = 57/129 (44%), Gaps = 12/129 (9%)
Query: 558 PHCFPLSLVPTEFCPSPPALKDGFVQDE--GTMFPVGKNVVYTCNEGYSLIGNPVARCGE 615
P C +S+ P E CP+ P + +G E G++ P G +V Y+C GY L+G + C
Sbjct: 144 PTC--VSVFPLE-CPALPMIHNGHHTSENVGSIAP-GLSVTYSCESGYLLVGEKIINCLS 199
Query: 616 DLRWLVGEMHCQKIAC-VLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC- 673
+W C++ C L +G P P VG C G L+GP + C
Sbjct: 200 SGKWSAVPPTCEEARCKSLGRFPNGKVKEP--PILRVGVTANFFCDEGYRLQGPPSSRCV 257
Query: 674 --GSSLKWS 680
G + W+
Sbjct: 258 IAGQGVAWT 266
Score = 49.7 bits (117), Expect = 1e-05
Identities = 34/124 (27%), Positives = 54/124 (43%), Gaps = 5/124 (4%)
Query: 562 PLSLVPTEFCPSPPALKDGFVQDEGTM-FPVGKNVVYTCNEGYSLIGNPVARCGEDLRWL 620
P + V + C +PP + +G +D + F G ++ Y+CN GY L+G +C + W
Sbjct: 401 PSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWT 460
Query: 621 VGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWS 680
C+ AC + + PQ F V V SC G L G C ++ W
Sbjct: 461 PPVPQCKVAACEATGRQ--LLTKPQHQF--VRPDVNSSCGEGYKLSGSVYQECQGTIPWF 516
Query: 681 PEMK 684
E++
Sbjct: 517 MEIR 520
Score = 49.7 bits (117), Expect = 1e-05
Identities = 55/221 (24%), Positives = 86/221 (38%), Gaps = 29/221 (13%)
Query: 544 QCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYT-CNEG 602
QC + H P L P CP+P +K G+ ++ ++VY CN G
Sbjct: 761 QCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPE-VKHGYKLNKTHSAYSHNDIVYVDCNPG 819
Query: 603 YSLIGNPVARCGEDLRWLVGEMHCQKIACV----LPVLMDGIQSHPQKPFYTVGEKVTVS 658
+ + G+ V RC D W+ G C K A + P +G + ++ G + S
Sbjct: 820 FIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYS 879
Query: 659 CSGGMSLEGPSAFLCGSSLKWS---PEMKNARC--------VQK---ENPLTQ----AVP 700
C G L G + LC WS P K C +QK + Q
Sbjct: 880 CDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTL 939
Query: 701 KCQRWEKLQNS-RCVCKMPYECGPSLDVCAQDERSKRILPL 740
+C+ L+ S + C+ ++ P L VC RS+ + P+
Sbjct: 940 ECEDGYMLEGSPQSQCQSDHQWNPPLAVC----RSRSLAPV 976
Score = 46.6 bits (109), Expect = 1e-04
Identities = 31/119 (26%), Positives = 49/119 (41%), Gaps = 9/119 (7%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC----GEDLRWLVGEMHC 626
C SPP + +G + T VG + Y+C+ + LIG C D W C
Sbjct: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82
Query: 627 QKI----ACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSP 681
+ +C P++ G + P Y G+ VT +C S+ G + C ++ W P
Sbjct: 83 EYFNKYSSCPEPIVPGGYKIRGSTP-YRHGDSVTFACKTNFSMNGNKSVWCQANNMWGP 140
Score = 43.5 bits (101), Expect = 8e-04
Identities = 32/132 (24%), Positives = 53/132 (40%), Gaps = 15/132 (11%)
Query: 571 CPSPPALKDGFVQDEGTM---FPVGKNVVYTCNEGYSLIGNPVARCGEDLR----WLVGE 623
C PP + +G + G M F G V Y C++G+ L+G +C D + W
Sbjct: 719 CHPPPVIVNG--KHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS 776
Query: 624 MHCQK----IACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKW 679
C + C P + G + + Y+ + V V C+ G + G C + W
Sbjct: 777 PQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTW 836
Query: 680 SPEMKNARCVQK 691
P + C++K
Sbjct: 837 VPGVPT--CIKK 846
Score = 40.4 bits (93), Expect = 0.007
Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 7/93 (7%)
Query: 591 VGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIAC-VLPVLMDGIQSHPQKPFY 649
V +V +C EGY L G+ C + W + C++I C PV+ +G + +
Sbjct: 487 VRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDF 546
Query: 650 TVGEKVTVSCSGG------MSLEGPSAFLCGSS 676
G VT +C+ G SL G S C S+
Sbjct: 547 PYGTTVTYTCNPGPERGVEFSLIGESTIRCTSN 579
Score = 40.0 bits (92), Expect = 0.009
Identities = 39/151 (25%), Positives = 56/151 (37%), Gaps = 7/151 (4%)
Query: 523 CNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFV 582
CN P G S +GE+T D+E P C LSL+ + C +
Sbjct: 556 CNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLC-KLSLLAVQ-CSHVHIANGYKI 613
Query: 583 QDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQS 642
+ + V + C G++L G+ RC D W C+K C QS
Sbjct: 614 SGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETC-----QHVRQS 668
Query: 643 HPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC 673
+ P + E V SC G L G + +C
Sbjct: 669 LQELPAGSRVELVNTSCQDGYQLTGHAYQMC 699
>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
isoform 1 [Homo sapiens]
Length = 1092
Score = 74.7 bits (182), Expect = 3e-13
Identities = 40/120 (33%), Positives = 58/120 (48%), Gaps = 4/120 (3%)
Query: 571 CPSPPALKDG-FVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKI 629
CP PP +G F G +++Y+C++GY L+G + C + W HC+++
Sbjct: 910 CPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEV 969
Query: 630 ACVLPVLMDGIQS--HPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNAR 687
C P MDGIQ P+K Y G VT+ C G LEG C S +W+P + R
Sbjct: 970 NCSSPADMDGIQKGLEPRK-MYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCR 1028
Score = 58.2 bits (139), Expect = 3e-08
Identities = 56/239 (23%), Positives = 90/239 (37%), Gaps = 7/239 (2%)
Query: 523 CNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFV 582
CN P G S +GE+T D+E P C LSL+ + C +
Sbjct: 556 CNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLC-KLSLLAVQ-CSHVHIANGYKI 613
Query: 583 QDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQS 642
+ + V + C G++L G+ RC D W C+K P L G +
Sbjct: 614 SGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKGCQSPPGLHHGRHT 673
Query: 643 HPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKC 702
F+ G V +C G L G + C S WSP RC + + Q++ +
Sbjct: 674 GGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSA--PRCEETCQHVRQSLQEL 731
Query: 703 QRWEKLQNSRCVCKMPYE-CGPSLDVCAQDERSKRILPLTVCKMHVLHCQGRNYTLTGR 760
+++ C+ Y+ G + +C E + +CK V+HC + G+
Sbjct: 732 PAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCK--VIHCHPPPVIVNGK 788
Score = 56.6 bits (135), Expect = 9e-08
Identities = 41/181 (22%), Positives = 69/181 (38%), Gaps = 2/181 (1%)
Query: 523 CNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFV 582
C+ P G +GE+T + ++ P C LS + CP P L+ V
Sbjct: 305 CDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRC-ELSTSAVQ-CPHPQILRGRMV 362
Query: 583 QDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQS 642
+ + V++ C G++L G+ RC W C+K P +++G +
Sbjct: 363 SGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKE 422
Query: 643 HPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKC 702
+ G + SC+ G L G + C S W+P + + E Q + K
Sbjct: 423 DRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKP 482
Query: 703 Q 703
Q
Sbjct: 483 Q 483
Score = 52.4 bits (124), Expect = 2e-06
Identities = 57/230 (24%), Positives = 88/230 (38%), Gaps = 33/230 (14%)
Query: 570 FCPSPPALKDG-FVQDEGTMFPVGKNVVYTCN----EG--YSLIGNPVARCGEDLR---- 618
FCPSPP + +G + + G V YTC+ EG + LIG RC D +
Sbjct: 275 FCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGT 334
Query: 619 WLVGEMHCQ----KIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCG 674
W C+ + C P ++ G QK YT + V +C G +L+G C
Sbjct: 335 WSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCN 394
Query: 675 SSLKWSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCV-----CKMPYECGPSLDVCA 729
+ W P +A +KE QA P +K ++ V + Y C P +
Sbjct: 395 AQGTWEP---SAPVCEKE---CQAPPNILNGQK-EDRHMVRFDPGTSIKYSCNPGYVLVG 447
Query: 730 QDE---RSKRIL--PLTVCKMHVLHCQGRNYTLTGRDSCTLPASAEKACG 774
++ S+ + P+ CK+ GR + P +CG
Sbjct: 448 EESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRP-DVNSSCG 496
Score = 52.0 bits (123), Expect = 2e-06
Identities = 36/128 (28%), Positives = 53/128 (41%), Gaps = 15/128 (11%)
Query: 571 CPSPPALKDGFVQDEGTM-FPVGKNVVYTCNEG------YSLIGNPVARCGEDLR----W 619
CP PP + +G FP G V YTCN G +SLIG RC + + W
Sbjct: 527 CPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTW 586
Query: 620 LVGEMHCQ----KIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGS 675
C+ + C + +G + ++ Y + VT C G +L+G S C +
Sbjct: 587 SGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKA 646
Query: 676 SLKWSPEM 683
W PE+
Sbjct: 647 DNTWDPEI 654
Score = 51.6 bits (122), Expect = 3e-06
Identities = 38/129 (29%), Positives = 57/129 (44%), Gaps = 12/129 (9%)
Query: 558 PHCFPLSLVPTEFCPSPPALKDGFVQDE--GTMFPVGKNVVYTCNEGYSLIGNPVARCGE 615
P C +S+ P E CP+ P + +G E G++ P G +V Y+C GY L+G + C
Sbjct: 144 PTC--VSVFPLE-CPALPMIHNGHHTSENVGSIAP-GLSVTYSCESGYLLVGEKIINCLS 199
Query: 616 DLRWLVGEMHCQKIAC-VLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC- 673
+W C++ C L +G P P VG C G L+GP + C
Sbjct: 200 SGKWSAVPPTCEEARCKSLGRFPNGKVKEP--PILRVGVTANFFCDEGYRLQGPPSSRCV 257
Query: 674 --GSSLKWS 680
G + W+
Sbjct: 258 IAGQGVAWT 266
Score = 49.7 bits (117), Expect = 1e-05
Identities = 34/124 (27%), Positives = 54/124 (43%), Gaps = 5/124 (4%)
Query: 562 PLSLVPTEFCPSPPALKDGFVQDEGTM-FPVGKNVVYTCNEGYSLIGNPVARCGEDLRWL 620
P + V + C +PP + +G +D + F G ++ Y+CN GY L+G +C + W
Sbjct: 401 PSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWT 460
Query: 621 VGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWS 680
C+ AC + + PQ F V V SC G L G C ++ W
Sbjct: 461 PPVPQCKVAACEATGRQ--LLTKPQHQF--VRPDVNSSCGEGYKLSGSVYQECQGTIPWF 516
Query: 681 PEMK 684
E++
Sbjct: 517 MEIR 520
Score = 49.7 bits (117), Expect = 1e-05
Identities = 55/221 (24%), Positives = 86/221 (38%), Gaps = 29/221 (13%)
Query: 544 QCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYT-CNEG 602
QC + H P L P CP+P +K G+ ++ ++VY CN G
Sbjct: 820 QCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPE-VKHGYKLNKTHSAYSHNDIVYVDCNPG 878
Query: 603 YSLIGNPVARCGEDLRWLVGEMHCQKIACV----LPVLMDGIQSHPQKPFYTVGEKVTVS 658
+ + G+ V RC D W+ G C K A + P +G + ++ G + S
Sbjct: 879 FIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYS 938
Query: 659 CSGGMSLEGPSAFLCGSSLKWS---PEMKNARC--------VQK---ENPLTQ----AVP 700
C G L G + LC WS P K C +QK + Q
Sbjct: 939 CDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTL 998
Query: 701 KCQRWEKLQNS-RCVCKMPYECGPSLDVCAQDERSKRILPL 740
+C+ L+ S + C+ ++ P L VC RS+ + P+
Sbjct: 999 ECEDGYMLEGSPQSQCQSDHQWNPPLAVC----RSRSLAPV 1035
Score = 46.6 bits (109), Expect = 1e-04
Identities = 31/119 (26%), Positives = 49/119 (41%), Gaps = 9/119 (7%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC----GEDLRWLVGEMHC 626
C SPP + +G + T VG + Y+C+ + LIG C D W C
Sbjct: 23 CGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKC 82
Query: 627 QKI----ACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSP 681
+ +C P++ G + P Y G+ VT +C S+ G + C ++ W P
Sbjct: 83 EYFNKYSSCPEPIVPGGYKIRGSTP-YRHGDSVTFACKTNFSMNGNKSVWCQANNMWGP 140
Score = 43.5 bits (101), Expect = 8e-04
Identities = 32/132 (24%), Positives = 53/132 (40%), Gaps = 15/132 (11%)
Query: 571 CPSPPALKDGFVQDEGTM---FPVGKNVVYTCNEGYSLIGNPVARCGEDLR----WLVGE 623
C PP + +G + G M F G V Y C++G+ L+G +C D + W
Sbjct: 778 CHPPPVIVNG--KHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPS 835
Query: 624 MHCQK----IACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKW 679
C + C P + G + + Y+ + V V C+ G + G C + W
Sbjct: 836 PQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTW 895
Query: 680 SPEMKNARCVQK 691
P + C++K
Sbjct: 896 VPGVPT--CIKK 905
Score = 40.4 bits (93), Expect = 0.007
Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 7/93 (7%)
Query: 591 VGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIAC-VLPVLMDGIQSHPQKPFY 649
V +V +C EGY L G+ C + W + C++I C PV+ +G + +
Sbjct: 487 VRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDF 546
Query: 650 TVGEKVTVSCSGG------MSLEGPSAFLCGSS 676
G VT +C+ G SL G S C S+
Sbjct: 547 PYGTTVTYTCNPGPERGVEFSLIGESTIRCTSN 579
>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
Length = 2489
Score = 73.2 bits (178), Expect = 1e-12
Identities = 45/177 (25%), Positives = 79/177 (44%), Gaps = 7/177 (3%)
Query: 517 KTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPA 576
K S C+ P G + +GE++ + + P C L CP PP
Sbjct: 2247 KEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRC---ELSVPAACPHPPK 2303
Query: 577 LKDG-FVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPV 635
+++G ++ +++ G + Y C+ GY L+G C + W + +C+++ C P+
Sbjct: 2304 IQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPL 2363
Query: 636 LMDGIQSH-PQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQK 691
M+GI K Y G+ VT+ C G +LEG C + +W P + A+C +
Sbjct: 2364 FMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL--AKCTSR 2418
Score = 55.5 bits (132), Expect = 2e-07
Identities = 37/170 (21%), Positives = 69/170 (40%), Gaps = 7/170 (4%)
Query: 522 ECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGF 581
+C+ P VGE + +D+++ P C + T C +P
Sbjct: 1997 QCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRC-----ISTNKCTAPEVENAIR 2051
Query: 582 VQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQ 641
V + F + + + + C G+ ++G+ +C + RW HC ++ P ++ G
Sbjct: 2052 VPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEH 2111
Query: 642 SHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQK 691
+ + ++ G++V SC L G ++ C WSPE RC K
Sbjct: 2112 TLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEA--PRCTVK 2159
Score = 52.4 bits (124), Expect = 2e-06
Identities = 39/163 (23%), Positives = 71/163 (43%), Gaps = 13/163 (7%)
Query: 523 CNNPPPSGGGRSC---VGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKD 579
CN P GGR VGE + D+++ P C ++P + +PP +++
Sbjct: 195 CN---PGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC----IIPNKC--TPPNVEN 245
Query: 580 GF-VQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMD 638
G V D ++F + + V + C G+ + G +C +W C ++ P ++
Sbjct: 246 GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH 305
Query: 639 GIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSP 681
++ K ++ G++V SC G L G ++ C WSP
Sbjct: 306 AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 348
Score = 52.4 bits (124), Expect = 2e-06
Identities = 39/163 (23%), Positives = 71/163 (43%), Gaps = 13/163 (7%)
Query: 523 CNNPPPSGGGRSC---VGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKD 579
CN P GGR VGE + D+++ P C ++P + +PP +++
Sbjct: 645 CN---PGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC----IIPNKC--TPPNVEN 695
Query: 580 GF-VQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMD 638
G V D ++F + + V + C G+ + G +C +W C ++ P ++
Sbjct: 696 GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH 755
Query: 639 GIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSP 681
++ K ++ G++V SC G L G ++ C WSP
Sbjct: 756 AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 798
Score = 52.4 bits (124), Expect = 2e-06
Identities = 39/163 (23%), Positives = 71/163 (43%), Gaps = 13/163 (7%)
Query: 523 CNNPPPSGGGRSC---VGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKD 579
CN P GGR VGE + D+++ P C ++P + +PP +++
Sbjct: 1095 CN---PGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC----IIPNKC--TPPNVEN 1145
Query: 580 GF-VQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMD 638
G V D ++F + + V + C G+ + G +C +W C ++ P ++
Sbjct: 1146 GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH 1205
Query: 639 GIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSP 681
++ K ++ G++V SC G L G ++ C WSP
Sbjct: 1206 AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 1248
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/131 (24%), Positives = 60/131 (45%), Gaps = 5/131 (3%)
Query: 562 PLSLVPTEFCPSPPALKDGF-VQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWL 620
P ++P + +PP +++G V D ++F + + V + C G+ + G +C +W
Sbjct: 1580 PQCIIPNKC--TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWE 1637
Query: 621 VGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWS 680
C ++ P ++ G + + ++ G++V SC G L G ++ C WS
Sbjct: 1638 PELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWS 1697
Query: 681 PEMKNARCVQK 691
PE RC K
Sbjct: 1698 PEA--PRCAVK 1706
Score = 50.4 bits (119), Expect = 7e-06
Identities = 43/169 (25%), Positives = 66/169 (39%), Gaps = 14/169 (8%)
Query: 571 CPSPPALKDG-FVQDEGTMFPVGKNVVYTCNEG------YSLIGNPVARC--GEDLRWLV 621
C PP + +G F+ F G V Y CN G + L+G P C +D +
Sbjct: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225
Query: 622 GEMHCQKIA---CVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLK 678
Q I C P + +GI + +++ E V C G ++GP C + K
Sbjct: 226 SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 285
Query: 679 WSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYECGPSLDV 727
W PE+ + V + P + QR N ++ Y C P D+
Sbjct: 286 WEPELPSCSRVCQPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDL 332
Score = 50.4 bits (119), Expect = 7e-06
Identities = 43/169 (25%), Positives = 66/169 (39%), Gaps = 14/169 (8%)
Query: 571 CPSPPALKDG-FVQDEGTMFPVGKNVVYTCNEG------YSLIGNPVARC--GEDLRWLV 621
C PP + +G F+ F G V Y CN G + L+G P C +D +
Sbjct: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
Query: 622 GEMHCQKIA---CVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLK 678
Q I C P + +GI + +++ E V C G ++GP C + K
Sbjct: 676 SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 735
Query: 679 WSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYECGPSLDV 727
W PE+ + V + P + QR N ++ Y C P D+
Sbjct: 736 WEPELPSCSRVCQPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDL 782
Score = 50.4 bits (119), Expect = 7e-06
Identities = 43/169 (25%), Positives = 66/169 (39%), Gaps = 14/169 (8%)
Query: 571 CPSPPALKDG-FVQDEGTMFPVGKNVVYTCNEG------YSLIGNPVARC--GEDLRWLV 621
C PP + +G F+ F G V Y CN G + L+G P C +D +
Sbjct: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125
Query: 622 GEMHCQKIA---CVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLK 678
Q I C P + +GI + +++ E V C G ++GP C + K
Sbjct: 1126 SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 1185
Query: 679 WSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYECGPSLDV 727
W PE+ + V + P + QR N ++ Y C P D+
Sbjct: 1186 WEPELPSCSRVCQPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDL 1232
Score = 47.8 bits (112), Expect = 4e-05
Identities = 36/136 (26%), Positives = 55/136 (40%), Gaps = 12/136 (8%)
Query: 571 CPSPPALKDG-FVQDEGTMFPVGKNVVYTCNEG------YSLIGNPVARC--GEDLRWLV 621
C PP + +G F+ F G V Y CN G + L+G P C +D +
Sbjct: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575
Query: 622 GEMHCQKIA---CVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLK 678
Q I C P + +GI + +++ E V C G ++GP C + K
Sbjct: 1576 SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 1635
Query: 679 WSPEMKNARCVQKENP 694
W PE+ + V + P
Sbjct: 1636 WEPELPSCSRVCQPPP 1651
Score = 45.4 bits (106), Expect = 2e-04
Identities = 35/125 (28%), Positives = 51/125 (40%), Gaps = 11/125 (8%)
Query: 562 PLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC---GEDLR 618
P + + C +PP +G V T VG + Y+C G+ LIG+ A C G
Sbjct: 545 PKDVCKRKSCKTPPDPVNGMVHVI-TDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAH 603
Query: 619 WLVGEMHCQKIACVL-PVLMDGIQSHPQKPFYTVGEKVTVSCSGG------MSLEGPSAF 671
W CQ+I C L P + +G + + G VT C+ G L G +
Sbjct: 604 WSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSI 663
Query: 672 LCGSS 676
C S+
Sbjct: 664 YCTSN 668
Score = 45.4 bits (106), Expect = 2e-04
Identities = 35/125 (28%), Positives = 51/125 (40%), Gaps = 11/125 (8%)
Query: 562 PLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC---GEDLR 618
P + + C +PP +G V T VG + Y+C G+ LIG+ A C G
Sbjct: 995 PKDVCKRKSCKTPPDPVNGMVHVI-TDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAH 1053
Query: 619 WLVGEMHCQKIACVL-PVLMDGIQSHPQKPFYTVGEKVTVSCSGG------MSLEGPSAF 671
W CQ+I C L P + +G + + G VT C+ G L G +
Sbjct: 1054 WSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSI 1113
Query: 672 LCGSS 676
C S+
Sbjct: 1114 YCTSN 1118
Score = 45.1 bits (105), Expect = 3e-04
Identities = 35/125 (28%), Positives = 51/125 (40%), Gaps = 11/125 (8%)
Query: 562 PLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC---GEDLR 618
P + + C +PP +G V T VG + Y+C G+ LIG+ A C G
Sbjct: 1445 PKDVCKRKSCKTPPDPVNGMVHVI-TDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAH 1503
Query: 619 WLVGEMHCQKIACVL-PVLMDGIQSHPQKPFYTVGEKVTVSCSGG------MSLEGPSAF 671
W CQ+I C L P + +G + + G VT C+ G L G +
Sbjct: 1504 WSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSI 1563
Query: 672 LCGSS 676
C S+
Sbjct: 1564 YCTSN 1568
Score = 43.5 bits (101), Expect = 8e-04
Identities = 31/104 (29%), Positives = 41/104 (39%), Gaps = 4/104 (3%)
Query: 572 PSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIAC 631
P P L Q + F G+ V Y+C GY L G RC W C+ +C
Sbjct: 299 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSC 358
Query: 632 --VLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC 673
+ L++G P +G KV C G L+G SA C
Sbjct: 359 DDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYC 400
Score = 43.5 bits (101), Expect = 8e-04
Identities = 31/104 (29%), Positives = 41/104 (39%), Gaps = 4/104 (3%)
Query: 572 PSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIAC 631
P P L Q + F G+ V Y+C GY L G RC W C+ +C
Sbjct: 749 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSC 808
Query: 632 --VLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC 673
+ L++G P +G KV C G L+G SA C
Sbjct: 809 DDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYC 850
Score = 43.5 bits (101), Expect = 8e-04
Identities = 31/104 (29%), Positives = 41/104 (39%), Gaps = 4/104 (3%)
Query: 572 PSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIAC 631
P P L Q + F G+ V Y+C GY L G RC W C+ +C
Sbjct: 1199 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSC 1258
Query: 632 --VLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC 673
+ L++G P +G KV C G L+G SA C
Sbjct: 1259 DDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYC 1300
Score = 43.1 bits (100), Expect = 0.001
Identities = 53/194 (27%), Positives = 76/194 (39%), Gaps = 36/194 (18%)
Query: 571 CPSPPALKDGFVQ-DEGTMFPVGKNVVYTCNEGYSLIGNPVARC---GEDLRWLVGEMHC 626
C PP +G V + T F G V Y+CNEG+ LIG+P C G ++ W C
Sbjct: 1907 CGPPPEPFNGMVHINTDTQF--GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPIC 1964
Query: 627 QKIAC-VLPVLMDGIQSHPQKPFYTVGEKVTVSCSGG------MSLEGPSAFLCGSSLK- 678
+ I+C P + +G + + G VT C G L G + C S
Sbjct: 1965 EIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQ 2024
Query: 679 ---WS--------------PEMKNARCVQKEN---PLTQAVP-KCQRWEKLQNSRCV-CK 716
WS PE++NA V LT+ + +CQ + S V C+
Sbjct: 2025 VGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQ 2084
Query: 717 MPYECGPSLDVCAQ 730
GP L C++
Sbjct: 2085 TNGRWGPKLPHCSR 2098
Score = 42.7 bits (99), Expect = 0.001
Identities = 34/117 (29%), Positives = 51/117 (43%), Gaps = 13/117 (11%)
Query: 571 CPSPPALKDGFVQD-EGTMFPVGKNVVYTCNEGYSLIGNPVARC---GEDLRWLVGEMHC 626
C +PP +G V +G F G + Y+C +GY LIG+ A C G+ + W C
Sbjct: 104 CRNPPDPVNGMVHVIKGIQF--GSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPIC 161
Query: 627 QKIACVL-PVLMDGIQSHPQKPFYTVGEKVTVSCSGG------MSLEGPSAFLCGSS 676
+I C L P + +G + + G VT C+ G L G + C S+
Sbjct: 162 DRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSN 218
Score = 42.4 bits (98), Expect = 0.002
Identities = 38/169 (22%), Positives = 66/169 (39%), Gaps = 14/169 (8%)
Query: 571 CPSPPALKDG-FVQDEGTMFPVGKNVVYTCNEG------YSLIGNPVARC-GEDLR---W 619
C PP + +G F + T F G V Y C+ G + L+G C +D + W
Sbjct: 1969 CEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVW 2028
Query: 620 LVGEMHCQKI-ACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLK 678
C C P + + I+ + F+T+ E + C G + G C ++ +
Sbjct: 2029 SSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGR 2088
Query: 679 WSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYECGPSLDV 727
W P++ + C + P + + N ++ Y C PS D+
Sbjct: 2089 WGPKLPH--CSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDL 2135
Score = 42.0 bits (97), Expect = 0.002
Identities = 36/128 (28%), Positives = 50/128 (39%), Gaps = 19/128 (14%)
Query: 570 FCPSPPALKDGFVQDEGTMF---PVGKNVVYTCNE------GYSLIGNPVARCGEDLR-- 618
FCP+PPA+ +G + GT F P GK + Y C+ ++LIG RC D +
Sbjct: 2223 FCPNPPAILNG--RHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN 2280
Query: 619 --WLVGEMHCQ---KIACV-LPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFL 672
W C+ AC P + +G Y G ++ C G L G
Sbjct: 2281 GVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIF 2340
Query: 673 CGSSLKWS 680
C WS
Sbjct: 2341 CTDQGIWS 2348
Score = 39.3 bits (90), Expect = 0.015
Identities = 35/121 (28%), Positives = 47/121 (38%), Gaps = 30/121 (24%)
Query: 570 FCPSPPALKDG-FVQDEGTMFPVGKNVVYTCN------EGYSLIGNPVARCGEDLR---- 618
FCPSPP + +G +FP GK V YTC+ + LIG RC D +
Sbjct: 420 FCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGV 479
Query: 619 WLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLK 678
W C GI H Q P + + K+ + S F G+SLK
Sbjct: 480 WSSPAPRC------------GILGHCQAPDHFLFAKLKTQTNA-------SDFPIGTSLK 520
Query: 679 W 679
+
Sbjct: 521 Y 521
Score = 39.3 bits (90), Expect = 0.015
Identities = 35/121 (28%), Positives = 47/121 (38%), Gaps = 30/121 (24%)
Query: 570 FCPSPPALKDG-FVQDEGTMFPVGKNVVYTCN------EGYSLIGNPVARCGEDLR---- 618
FCPSPP + +G +FP GK V YTC+ + LIG RC D +
Sbjct: 870 FCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGV 929
Query: 619 WLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLK 678
W C GI H Q P + + K+ + S F G+SLK
Sbjct: 930 WSSPAPRC------------GILGHCQAPDHFLFAKLKTQTNA-------SDFPIGTSLK 970
Query: 679 W 679
+
Sbjct: 971 Y 971
Score = 38.9 bits (89), Expect = 0.020
Identities = 52/211 (24%), Positives = 69/211 (32%), Gaps = 33/211 (15%)
Query: 506 WSSWSP-CVQGKKTRSRECNNPPPSGGGRSCVGET---------------TESTQCEDEE 549
WSS P C+ K + E N G RS T + + QC+
Sbjct: 2028 WSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNG 2087
Query: 550 LEHLRLLEPHCFPLSLVPTEFCPSPPALKDG-FVQDEGTMFPVGKNVVYTCNEGYSLIGN 608
+L PHC + C PP + G F G+ V Y+C Y L G
Sbjct: 2088 RWGPKL--PHC-------SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGA 2138
Query: 609 PVARCGEDLRWLVGEMHCQKIAC--VLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLE 666
C W C +C L L G P +G KV+ C G L+
Sbjct: 2139 ASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLK 2196
Query: 667 GPSAFLC---GSSLKWSPEMKNARCVQKENP 694
G SA C G W+ + + NP
Sbjct: 2197 GRSASHCVLAGMKALWNSSVPVCEQIFCPNP 2227
Score = 38.5 bits (88), Expect = 0.026
Identities = 35/121 (28%), Positives = 47/121 (38%), Gaps = 30/121 (24%)
Query: 570 FCPSPPALKDG-FVQDEGTMFPVGKNVVYTCN------EGYSLIGNPVARCGEDLR---- 618
FCPSPP + +G +FP GK V YTC+ + LIG RC D +
Sbjct: 1320 FCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGV 1379
Query: 619 WLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLK 678
W C GI H Q P + + K+ + S F G+SLK
Sbjct: 1380 WSSPAPRC------------GILGHCQAPDHFLFAKLKTQTNA-------SDFPIGTSLK 1420
Query: 679 W 679
+
Sbjct: 1421 Y 1421
Score = 37.7 bits (86), Expect = 0.045
Identities = 43/174 (24%), Positives = 68/174 (39%), Gaps = 22/174 (12%)
Query: 517 KTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPA 576
KT + C+ P G +GE+T + + P C L C +P
Sbjct: 444 KTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILG-----HCQAP-- 496
Query: 577 LKDGFV------QDEGTMFPVGKNVVYTCNEGYSLIGNPVA-RCGEDLRWLVGEMHCQKI 629
D F+ Q + FP+G ++ Y C Y G P + C ++L W + C++
Sbjct: 497 --DHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRK 552
Query: 630 ACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC---GSSLKWS 680
+C P H VG ++ SC+ G L G S+ C G++ WS
Sbjct: 553 SCKTPPDPVNGMVHVITDI-QVGSRINYSCTTGHRLIGHSSAECILSGNAAHWS 605
Score = 37.7 bits (86), Expect = 0.045
Identities = 43/174 (24%), Positives = 68/174 (39%), Gaps = 22/174 (12%)
Query: 517 KTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPA 576
KT + C+ P G +GE+T + + P C L C +P
Sbjct: 894 KTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILG-----HCQAP-- 946
Query: 577 LKDGFV------QDEGTMFPVGKNVVYTCNEGYSLIGNPVA-RCGEDLRWLVGEMHCQKI 629
D F+ Q + FP+G ++ Y C Y G P + C ++L W + C++
Sbjct: 947 --DHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRK 1002
Query: 630 ACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC---GSSLKWS 680
+C P H VG ++ SC+ G L G S+ C G++ WS
Sbjct: 1003 SCKTPPDPVNGMVHVITDI-QVGSRINYSCTTGHRLIGHSSAECILSGNAAHWS 1055
Score = 37.7 bits (86), Expect = 0.045
Identities = 38/138 (27%), Positives = 52/138 (37%), Gaps = 24/138 (17%)
Query: 570 FCPSPPALKDGFVQDEGTM---FPVGKNVVYTCNE------GYSLIGNPVARCGEDLRWL 620
FCP+PPA+ +G + GT P GK + YTC+ ++LIG RC D
Sbjct: 1770 FCPNPPAILNG--RHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHG- 1826
Query: 621 VGEMHCQKIACVLPVLMDGIQSHPQKPF-----------YTVGEKVTVSCSGGMSLEGPS 669
G C L V ++ Q PF + VG + C G
Sbjct: 1827 NGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGY-FGKMF 1885
Query: 670 AFLCGSSLKWSPEMKNAR 687
+ C +L WS N R
Sbjct: 1886 SISCLENLVWSSVEDNCR 1903
Score = 36.2 bits (82), Expect = 0.13
Identities = 30/106 (28%), Positives = 37/106 (34%), Gaps = 5/106 (4%)
Query: 571 CPSPPALKDG-FVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKI 629
C PP + G F G+ V Y+C GY L G C W C
Sbjct: 1647 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVK 1706
Query: 630 AC--VLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC 673
+C L L G P +G KV+ C G L+G S C
Sbjct: 1707 SCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHC 1750
Score = 35.8 bits (81), Expect = 0.17
Identities = 28/98 (28%), Positives = 43/98 (43%), Gaps = 7/98 (7%)
Query: 589 FPVGKNVVYTCNEGYSLIGNPVA-RCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKP 647
FP+G + Y C GYS G P + C ++ W + C++ +C P H K
Sbjct: 63 FPIGTYLNYECRPGYS--GRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKG 120
Query: 648 FYTVGEKVTVSCSGGMSLEGPSAFLC---GSSLKWSPE 682
G ++ SC+ G L G S+ C G ++ W E
Sbjct: 121 I-QFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNE 157
Score = 35.8 bits (81), Expect = 0.17
Identities = 28/102 (27%), Positives = 45/102 (44%), Gaps = 7/102 (6%)
Query: 583 QDEGTMFPVGKNVVYTCNEGYSLIGNPVA-RCGEDLRWLVGEMHCQKIACVLPVLMDGIQ 641
Q + FP+G ++ Y C Y G P + C ++L W + C++ +C P
Sbjct: 1407 QTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGM 1464
Query: 642 SHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC---GSSLKWS 680
H VG ++ SC+ G L G S+ C G++ WS
Sbjct: 1465 VHVITDI-QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWS 1505
>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
Length = 2039
Score = 73.2 bits (178), Expect = 1e-12
Identities = 45/177 (25%), Positives = 79/177 (44%), Gaps = 7/177 (3%)
Query: 517 KTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPA 576
K S C+ P G + +GE++ + + P C L CP PP
Sbjct: 1797 KEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRC---ELSVPAACPHPPK 1853
Query: 577 LKDG-FVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPV 635
+++G ++ +++ G + Y C+ GY L+G C + W + +C+++ C P+
Sbjct: 1854 IQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPL 1913
Query: 636 LMDGIQSH-PQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQK 691
M+GI K Y G+ VT+ C G +LEG C + +W P + A+C +
Sbjct: 1914 FMNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPL--AKCTSR 1968
Score = 55.5 bits (132), Expect = 2e-07
Identities = 37/170 (21%), Positives = 69/170 (40%), Gaps = 7/170 (4%)
Query: 522 ECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGF 581
+C+ P VGE + +D+++ P C + T C +P
Sbjct: 1547 QCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRC-----ISTNKCTAPEVENAIR 1601
Query: 582 VQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQ 641
V + F + + + + C G+ ++G+ +C + RW HC ++ P ++ G
Sbjct: 1602 VPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEH 1661
Query: 642 SHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQK 691
+ + ++ G++V SC L G ++ C WSPE RC K
Sbjct: 1662 TLSHQDNFSPGQEVFYSCEPSYDLRGAASLHCTPQGDWSPEA--PRCTVK 1709
Score = 52.4 bits (124), Expect = 2e-06
Identities = 39/163 (23%), Positives = 71/163 (43%), Gaps = 13/163 (7%)
Query: 523 CNNPPPSGGGRSC---VGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKD 579
CN P GGR VGE + D+++ P C ++P + +PP +++
Sbjct: 195 CN---PGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC----IIPNKC--TPPNVEN 245
Query: 580 GF-VQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMD 638
G V D ++F + + V + C G+ + G +C +W C ++ P ++
Sbjct: 246 GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH 305
Query: 639 GIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSP 681
++ K ++ G++V SC G L G ++ C WSP
Sbjct: 306 AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 348
Score = 52.4 bits (124), Expect = 2e-06
Identities = 39/163 (23%), Positives = 71/163 (43%), Gaps = 13/163 (7%)
Query: 523 CNNPPPSGGGRSC---VGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKD 579
CN P GGR VGE + D+++ P C ++P + +PP +++
Sbjct: 645 CN---PGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC----IIPNKC--TPPNVEN 695
Query: 580 GF-VQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMD 638
G V D ++F + + V + C G+ + G +C +W C ++ P ++
Sbjct: 696 GILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLH 755
Query: 639 GIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSP 681
++ K ++ G++V SC G L G ++ C WSP
Sbjct: 756 AERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP 798
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/131 (24%), Positives = 60/131 (45%), Gaps = 5/131 (3%)
Query: 562 PLSLVPTEFCPSPPALKDGF-VQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWL 620
P ++P + +PP +++G V D ++F + + V + C G+ + G +C +W
Sbjct: 1130 PQCIIPNKC--TPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWE 1187
Query: 621 VGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWS 680
C ++ P ++ G + + ++ G++V SC G L G ++ C WS
Sbjct: 1188 PELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWS 1247
Query: 681 PEMKNARCVQK 691
PE RC K
Sbjct: 1248 PEA--PRCAVK 1256
Score = 50.4 bits (119), Expect = 7e-06
Identities = 43/169 (25%), Positives = 66/169 (39%), Gaps = 14/169 (8%)
Query: 571 CPSPPALKDG-FVQDEGTMFPVGKNVVYTCNEG------YSLIGNPVARC--GEDLRWLV 621
C PP + +G F+ F G V Y CN G + L+G P C +D +
Sbjct: 166 CGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 225
Query: 622 GEMHCQKIA---CVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLK 678
Q I C P + +GI + +++ E V C G ++GP C + K
Sbjct: 226 SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 285
Query: 679 WSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYECGPSLDV 727
W PE+ + V + P + QR N ++ Y C P D+
Sbjct: 286 WEPELPSCSRVCQPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDL 332
Score = 50.4 bits (119), Expect = 7e-06
Identities = 43/169 (25%), Positives = 66/169 (39%), Gaps = 14/169 (8%)
Query: 571 CPSPPALKDG-FVQDEGTMFPVGKNVVYTCNEG------YSLIGNPVARC--GEDLRWLV 621
C PP + +G F+ F G V Y CN G + L+G P C +D +
Sbjct: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675
Query: 622 GEMHCQKIA---CVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLK 678
Q I C P + +GI + +++ E V C G ++GP C + K
Sbjct: 676 SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 735
Query: 679 WSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYECGPSLDV 727
W PE+ + V + P + QR N ++ Y C P D+
Sbjct: 736 WEPELPSCSRVCQPPPDVLHAERTQR--DKDNFSPGQEVFYSCEPGYDL 782
Score = 47.8 bits (112), Expect = 4e-05
Identities = 36/136 (26%), Positives = 55/136 (40%), Gaps = 12/136 (8%)
Query: 571 CPSPPALKDG-FVQDEGTMFPVGKNVVYTCNEG------YSLIGNPVARC--GEDLRWLV 621
C PP + +G F+ F G V Y CN G + L+G P C +D +
Sbjct: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1125
Query: 622 GEMHCQKIA---CVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLK 678
Q I C P + +GI + +++ E V C G ++GP C + K
Sbjct: 1126 SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 1185
Query: 679 WSPEMKNARCVQKENP 694
W PE+ + V + P
Sbjct: 1186 WEPELPSCSRVCQPPP 1201
Score = 45.4 bits (106), Expect = 2e-04
Identities = 35/125 (28%), Positives = 51/125 (40%), Gaps = 11/125 (8%)
Query: 562 PLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC---GEDLR 618
P + + C +PP +G V T VG + Y+C G+ LIG+ A C G
Sbjct: 545 PKDVCKRKSCKTPPDPVNGMVHVI-TDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAH 603
Query: 619 WLVGEMHCQKIACVL-PVLMDGIQSHPQKPFYTVGEKVTVSCSGG------MSLEGPSAF 671
W CQ+I C L P + +G + + G VT C+ G L G +
Sbjct: 604 WSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSI 663
Query: 672 LCGSS 676
C S+
Sbjct: 664 YCTSN 668
Score = 45.1 bits (105), Expect = 3e-04
Identities = 35/125 (28%), Positives = 51/125 (40%), Gaps = 11/125 (8%)
Query: 562 PLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC---GEDLR 618
P + + C +PP +G V T VG + Y+C G+ LIG+ A C G
Sbjct: 995 PKDVCKRKSCKTPPDPVNGMVHVI-TDIQVGSRINYSCTTGHRLIGHSSAECILSGNTAH 1053
Query: 619 WLVGEMHCQKIACVL-PVLMDGIQSHPQKPFYTVGEKVTVSCSGG------MSLEGPSAF 671
W CQ+I C L P + +G + + G VT C+ G L G +
Sbjct: 1054 WSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSI 1113
Query: 672 LCGSS 676
C S+
Sbjct: 1114 YCTSN 1118
Score = 43.5 bits (101), Expect = 8e-04
Identities = 31/104 (29%), Positives = 41/104 (39%), Gaps = 4/104 (3%)
Query: 572 PSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIAC 631
P P L Q + F G+ V Y+C GY L G RC W C+ +C
Sbjct: 299 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSC 358
Query: 632 --VLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC 673
+ L++G P +G KV C G L+G SA C
Sbjct: 359 DDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYC 400
Score = 43.5 bits (101), Expect = 8e-04
Identities = 31/104 (29%), Positives = 41/104 (39%), Gaps = 4/104 (3%)
Query: 572 PSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIAC 631
P P L Q + F G+ V Y+C GY L G RC W C+ +C
Sbjct: 749 PPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSC 808
Query: 632 --VLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC 673
+ L++G P +G KV C G L+G SA C
Sbjct: 809 DDFMGQLLNGRVLFPVN--LQLGAKVDFVCDEGFQLKGSSASYC 850
Score = 43.1 bits (100), Expect = 0.001
Identities = 53/194 (27%), Positives = 76/194 (39%), Gaps = 36/194 (18%)
Query: 571 CPSPPALKDGFVQ-DEGTMFPVGKNVVYTCNEGYSLIGNPVARC---GEDLRWLVGEMHC 626
C PP +G V + T F G V Y+CNEG+ LIG+P C G ++ W C
Sbjct: 1457 CGPPPEPFNGMVHINTDTQF--GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPIC 1514
Query: 627 QKIAC-VLPVLMDGIQSHPQKPFYTVGEKVTVSCSGG------MSLEGPSAFLCGSSLK- 678
+ I+C P + +G + + G VT C G L G + C S
Sbjct: 1515 EIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQ 1574
Query: 679 ---WS--------------PEMKNARCVQKEN---PLTQAVP-KCQRWEKLQNSRCV-CK 716
WS PE++NA V LT+ + +CQ + S V C+
Sbjct: 1575 VGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQ 1634
Query: 717 MPYECGPSLDVCAQ 730
GP L C++
Sbjct: 1635 TNGRWGPKLPHCSR 1648
Score = 42.7 bits (99), Expect = 0.001
Identities = 34/117 (29%), Positives = 51/117 (43%), Gaps = 13/117 (11%)
Query: 571 CPSPPALKDGFVQD-EGTMFPVGKNVVYTCNEGYSLIGNPVARC---GEDLRWLVGEMHC 626
C +PP +G V +G F G + Y+C +GY LIG+ A C G+ + W C
Sbjct: 104 CRNPPDPVNGMVHVIKGIQF--GSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPIC 161
Query: 627 QKIACVL-PVLMDGIQSHPQKPFYTVGEKVTVSCSGG------MSLEGPSAFLCGSS 676
+I C L P + +G + + G VT C+ G L G + C S+
Sbjct: 162 DRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSN 218
Score = 42.4 bits (98), Expect = 0.002
Identities = 38/169 (22%), Positives = 66/169 (39%), Gaps = 14/169 (8%)
Query: 571 CPSPPALKDG-FVQDEGTMFPVGKNVVYTCNEG------YSLIGNPVARC-GEDLR---W 619
C PP + +G F + T F G V Y C+ G + L+G C +D + W
Sbjct: 1519 CEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVW 1578
Query: 620 LVGEMHCQKI-ACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLK 678
C C P + + I+ + F+T+ E + C G + G C ++ +
Sbjct: 1579 SSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNGR 1638
Query: 679 WSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYECGPSLDV 727
W P++ + C + P + + N ++ Y C PS D+
Sbjct: 1639 WGPKLPH--CSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDL 1685
Score = 42.0 bits (97), Expect = 0.002
Identities = 36/128 (28%), Positives = 50/128 (39%), Gaps = 19/128 (14%)
Query: 570 FCPSPPALKDGFVQDEGTMF---PVGKNVVYTCNE------GYSLIGNPVARCGEDLR-- 618
FCP+PPA+ +G + GT F P GK + Y C+ ++LIG RC D +
Sbjct: 1773 FCPNPPAILNG--RHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGN 1830
Query: 619 --WLVGEMHCQ---KIACV-LPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFL 672
W C+ AC P + +G Y G ++ C G L G
Sbjct: 1831 GVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIF 1890
Query: 673 CGSSLKWS 680
C WS
Sbjct: 1891 CTDQGIWS 1898
Score = 39.3 bits (90), Expect = 0.015
Identities = 35/121 (28%), Positives = 47/121 (38%), Gaps = 30/121 (24%)
Query: 570 FCPSPPALKDG-FVQDEGTMFPVGKNVVYTCN------EGYSLIGNPVARCGEDLR---- 618
FCPSPP + +G +FP GK V YTC+ + LIG RC D +
Sbjct: 420 FCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGV 479
Query: 619 WLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLK 678
W C GI H Q P + + K+ + S F G+SLK
Sbjct: 480 WSSPAPRC------------GILGHCQAPDHFLFAKLKTQTNA-------SDFPIGTSLK 520
Query: 679 W 679
+
Sbjct: 521 Y 521
Score = 38.9 bits (89), Expect = 0.020
Identities = 52/211 (24%), Positives = 69/211 (32%), Gaps = 33/211 (15%)
Query: 506 WSSWSP-CVQGKKTRSRECNNPPPSGGGRSCVGET---------------TESTQCEDEE 549
WSS P C+ K + E N G RS T + + QC+
Sbjct: 1578 WSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQCQTNG 1637
Query: 550 LEHLRLLEPHCFPLSLVPTEFCPSPPALKDG-FVQDEGTMFPVGKNVVYTCNEGYSLIGN 608
+L PHC + C PP + G F G+ V Y+C Y L G
Sbjct: 1638 RWGPKL--PHC-------SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGA 1688
Query: 609 PVARCGEDLRWLVGEMHCQKIAC--VLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLE 666
C W C +C L L G P +G KV+ C G L+
Sbjct: 1689 ASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLN--LQLGAKVSFVCDEGFRLK 1746
Query: 667 GPSAFLC---GSSLKWSPEMKNARCVQKENP 694
G SA C G W+ + + NP
Sbjct: 1747 GRSASHCVLAGMKALWNSSVPVCEQIFCPNP 1777
Score = 38.5 bits (88), Expect = 0.026
Identities = 35/121 (28%), Positives = 47/121 (38%), Gaps = 30/121 (24%)
Query: 570 FCPSPPALKDG-FVQDEGTMFPVGKNVVYTCN------EGYSLIGNPVARCGEDLR---- 618
FCPSPP + +G +FP GK V YTC+ + LIG RC D +
Sbjct: 870 FCPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGV 929
Query: 619 WLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLK 678
W C GI H Q P + + K+ + S F G+SLK
Sbjct: 930 WSSPAPRC------------GILGHCQAPDHFLFAKLKTQTNA-------SDFPIGTSLK 970
Query: 679 W 679
+
Sbjct: 971 Y 971
Score = 37.7 bits (86), Expect = 0.045
Identities = 43/174 (24%), Positives = 68/174 (39%), Gaps = 22/174 (12%)
Query: 517 KTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPA 576
KT + C+ P G +GE+T + + P C L C +P
Sbjct: 444 KTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILG-----HCQAP-- 496
Query: 577 LKDGFV------QDEGTMFPVGKNVVYTCNEGYSLIGNPVA-RCGEDLRWLVGEMHCQKI 629
D F+ Q + FP+G ++ Y C Y G P + C ++L W + C++
Sbjct: 497 --DHFLFAKLKTQTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRK 552
Query: 630 ACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC---GSSLKWS 680
+C P H VG ++ SC+ G L G S+ C G++ WS
Sbjct: 553 SCKTPPDPVNGMVHVITDI-QVGSRINYSCTTGHRLIGHSSAECILSGNAAHWS 605
Score = 37.7 bits (86), Expect = 0.045
Identities = 38/138 (27%), Positives = 52/138 (37%), Gaps = 24/138 (17%)
Query: 570 FCPSPPALKDGFVQDEGTM---FPVGKNVVYTCNE------GYSLIGNPVARCGEDLRWL 620
FCP+PPA+ +G + GT P GK + YTC+ ++LIG RC D
Sbjct: 1320 FCPNPPAILNG--RHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHG- 1376
Query: 621 VGEMHCQKIACVLPVLMDGIQSHPQKPF-----------YTVGEKVTVSCSGGMSLEGPS 669
G C L V ++ Q PF + VG + C G
Sbjct: 1377 NGVWSSPAPRCELSVRAGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGY-FGKMF 1435
Query: 670 AFLCGSSLKWSPEMKNAR 687
+ C +L WS N R
Sbjct: 1436 SISCLENLVWSSVEDNCR 1453
Score = 36.2 bits (82), Expect = 0.13
Identities = 30/106 (28%), Positives = 37/106 (34%), Gaps = 5/106 (4%)
Query: 571 CPSPPALKDG-FVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKI 629
C PP + G F G+ V Y+C GY L G C W C
Sbjct: 1197 CQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVK 1256
Query: 630 AC--VLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC 673
+C L L G P +G KV+ C G L+G S C
Sbjct: 1257 SCDDFLGQLPHGRVLFPLN--LQLGAKVSFVCDEGFRLKGSSVSHC 1300
Score = 35.8 bits (81), Expect = 0.17
Identities = 28/98 (28%), Positives = 43/98 (43%), Gaps = 7/98 (7%)
Query: 589 FPVGKNVVYTCNEGYSLIGNPVA-RCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKP 647
FP+G + Y C GYS G P + C ++ W + C++ +C P H K
Sbjct: 63 FPIGTYLNYECRPGYS--GRPFSIICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKG 120
Query: 648 FYTVGEKVTVSCSGGMSLEGPSAFLC---GSSLKWSPE 682
G ++ SC+ G L G S+ C G ++ W E
Sbjct: 121 I-QFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNE 157
Score = 35.8 bits (81), Expect = 0.17
Identities = 28/102 (27%), Positives = 45/102 (44%), Gaps = 7/102 (6%)
Query: 583 QDEGTMFPVGKNVVYTCNEGYSLIGNPVA-RCGEDLRWLVGEMHCQKIACVLPVLMDGIQ 641
Q + FP+G ++ Y C Y G P + C ++L W + C++ +C P
Sbjct: 957 QTNASDFPIGTSLKYECRPEY--YGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGM 1014
Query: 642 SHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC---GSSLKWS 680
H VG ++ SC+ G L G S+ C G++ WS
Sbjct: 1015 VHVITDI-QVGSRINYSCTTGHRLIGHSSAECILSGNTAHWS 1055
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 67.4 bits (163), Expect = 5e-11
Identities = 43/110 (39%), Positives = 53/110 (48%), Gaps = 18/110 (16%)
Query: 473 CLCHCK------PYTFGAACE-QGVLVGNQAGGVDGGWSCWSSWSPCVQ----GKKTRSR 521
CLC + P G CE G+ + N + +GGW+ W+SWSPC G + R R
Sbjct: 563 CLCRTRSCDSPAPQCGGWQCEGPGMEIANCSR--NGGWTPWTSWSPCSTTCGIGFQVRQR 620
Query: 522 ECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFC 571
C+NP P GGR CVG+ E C EHL L PH F P E C
Sbjct: 621 SCSNPTPRHGGRVCVGQNREERYCN----EHL-LCPPHMFWTGWGPWERC 665
Score = 55.1 bits (131), Expect = 3e-07
Identities = 23/51 (45%), Positives = 30/51 (58%), Gaps = 4/51 (7%)
Query: 499 VDGGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQC 545
V+G WS W+SWS C + G + R R CNNP P GG C+G + E +C
Sbjct: 783 VNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQEC 833
Score = 54.7 bits (130), Expect = 4e-07
Identities = 24/54 (44%), Positives = 30/54 (55%), Gaps = 4/54 (7%)
Query: 499 VDGGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQCEDE 548
VDG WSCWS W+ C G R+R C+NP P+ GG C+G TE C +
Sbjct: 840 VDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQ 893
Score = 41.6 bits (96), Expect = 0.003
Identities = 20/54 (37%), Positives = 25/54 (46%), Gaps = 7/54 (12%)
Query: 499 VDGGWSCWSSWSPC-------VQGKKTRSRECNNPPPSGGGRSCVGETTESTQC 545
VDG + WS W+PC V R+R C++P P GG C G E C
Sbjct: 539 VDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANC 592
Score = 38.9 bits (89), Expect = 0.020
Identities = 24/76 (31%), Positives = 36/76 (47%), Gaps = 5/76 (6%)
Query: 11 GFIGEFQSFSSASS-PVNCQWDFYAPWSECN-GCTKTQTRRRSVAVYGQ--YGGQPCVGN 66
G G+F S+ VN W + WS+C+ C++ R+ V + YGG PC+G
Sbjct: 767 GLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGP 826
Query: 67 AFETQSCEPTRGCPTE 82
+ E Q C CP +
Sbjct: 827 SLEYQECN-ILPCPVD 841
Score = 38.9 bits (89), Expect = 0.020
Identities = 20/44 (45%), Positives = 23/44 (52%), Gaps = 3/44 (6%)
Query: 503 WSCWSSWSPC-VQGKKTRSRECNNPPPSGGGRSCVGETTESTQC 545
WS WS WS C G + R+R+C P G C G TTES C
Sbjct: 899 WSEWSDWSECEASGVQVRARQCILLFPMGS--QCSGNTTESRPC 940
Score = 36.6 bits (83), Expect = 0.10
Identities = 32/134 (23%), Positives = 54/134 (40%), Gaps = 15/134 (11%)
Query: 33 YAPWSECNGCTKT-----QTRRRSVA-VYGQYGGQPCVGNAFETQSCEPTRGCPTE---E 83
+ PW+ + C+ T Q R+RS + ++GG+ CVG E + C CP
Sbjct: 598 WTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHMFWT 657
Query: 84 GCGERFRCFS---GQCISKSLVCNGDSDCDEDSADEDRCEDSERRPSCDIDKPPPNIELT 140
G G RC + G ++ +C DC + + C + P ++ K P T
Sbjct: 658 GWGPWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNTN---PCPELKKTTPWTPWT 714
Query: 141 GNGYNELTGQFRNR 154
++ G + R
Sbjct: 715 PVNISDNGGHYEQR 728
Score = 33.1 bits (74), Expect = 1.1
Identities = 22/70 (31%), Positives = 33/70 (47%), Gaps = 6/70 (8%)
Query: 15 EFQSFSSASSPVNCQWDFYAPWSECN----GCTKTQTRRRSVAVYGQYGGQPCVGNAFET 70
E+Q + PV+ W ++PW++C+ G +TR S YGG C+G E
Sbjct: 829 EYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPA-PAYGGDICLGLHTEE 887
Query: 71 QSCEPTRGCP 80
C T+ CP
Sbjct: 888 ALCN-TQPCP 896
>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
Length = 1231
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/156 (28%), Positives = 71/156 (45%), Gaps = 10/156 (6%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC-GEDLRWLVGEMHCQKI 629
C SPP + G V + G+ V Y C EG+ + G +A+C GE +W C K
Sbjct: 931 CKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE--KW-SHPPSCIKT 987
Query: 630 ACV-LPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWS--PEMKNA 686
C+ LP + I +K Y GE+VT +C+ ++G S C +S +W+ P ++
Sbjct: 988 DCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINS-RWTGRPTCRDT 1046
Query: 687 RCVQKENPLTQAVPKCQ--RWEKLQNSRCVCKMPYE 720
CV + Q ++ + R C+ PYE
Sbjct: 1047 SCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYE 1082
Score = 56.6 bits (135), Expect = 9e-08
Identities = 67/260 (25%), Positives = 91/260 (35%), Gaps = 49/260 (18%)
Query: 505 CWSSWSPCVQGKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFP-- 562
C W+ CV + +CN PP G ++ T E + + C P
Sbjct: 9 CLMLWAICV------AEDCNELPPRRNTEILTGSWSDQTYPEGTQAIY------KCRPGY 56
Query: 563 ---------------LSLVPTEFCPSPPALKDG------FVQDEGTMFPVGKNVVYTCNE 601
++L P C P G F G +F G VYTCNE
Sbjct: 57 RSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNE 116
Query: 602 GYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLM---DGIQSHPQKP--FYTVGEKVT 656
GY L+G R + W C+ + C LPV I S +P Y G+ V
Sbjct: 117 GYQLLGEINYRECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVR 175
Query: 657 VSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQ---KENPLTQAVPKCQRWEKLQNSR- 712
C+ G +EG C WS E +CV+ K + P Q+ +N R
Sbjct: 176 FVCNSGYKIEGDEEMHCSDDGFWSKE--KPKCVEISCKSPDVINGSPISQKIIYKENERF 233
Query: 713 -CVCKMPYECGPSLD-VCAQ 730
C M YE D VC +
Sbjct: 234 QYKCNMGYEYSERGDAVCTE 253
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/90 (27%), Positives = 39/90 (43%), Gaps = 2/90 (2%)
Query: 592 GKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTV 651
G+ V + CN GY + G+ C +D W + C +I+C P +++G QK Y
Sbjct: 171 GQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVING-SPISQKIIYKE 229
Query: 652 GEKVTVSCSGGMSLEGPSAFLCGSSLKWSP 681
E+ C+ G +C S W P
Sbjct: 230 NERFQYKCNMGYEYSERGDAVCTES-GWRP 258
Score = 41.6 bits (96), Expect = 0.003
Identities = 31/130 (23%), Positives = 51/130 (39%), Gaps = 7/130 (5%)
Query: 564 SLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGE 623
S+ + CP PP + + + G+ V C E Y + C +D RW
Sbjct: 804 SMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITC-KDGRWQSIP 862
Query: 624 MHCQKIACVLPVLMDG---IQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWS 680
+ +KI C P ++ S + Y G K++ +C GG + + C KWS
Sbjct: 863 LCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMG-KWS 921
Query: 681 --PEMKNARC 688
P+ + C
Sbjct: 922 SPPQCEGLPC 931
Score = 37.0 bits (84), Expect = 0.077
Identities = 28/104 (26%), Positives = 48/104 (46%), Gaps = 9/104 (8%)
Query: 575 PALKDGFVQDEGTMFPVGKNVVYTCNEGY-----SLIGNPVARCGEDLRWLVGEMHCQKI 629
P + +++ T F + + Y C++GY S G+ V CG + W + C +
Sbjct: 512 PVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIV--CGYN-GWSDLPI-CYER 567
Query: 630 ACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC 673
C LP + + +K Y VGE + SC G ++ GP++ C
Sbjct: 568 ECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQC 611
Score = 33.9 bits (76), Expect = 0.65
Identities = 29/125 (23%), Positives = 48/125 (38%), Gaps = 29/125 (23%)
Query: 510 SPCVQGKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHC--------- 560
SP + K + + C PP G V E T+ EE H ++E +C
Sbjct: 617 SPDLPICKEQVQSCGPPPELLNGN--VKEKTK------EEYGHSEVVEYYCNPRFLMKGP 668
Query: 561 ------------FPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGN 608
P+ +V C P L+ G+ Q + G +V + C+E +++IG+
Sbjct: 669 NKIQCVDGEWTTLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGH 728
Query: 609 PVARC 613
C
Sbjct: 729 RSITC 733
Score = 31.6 bits (70), Expect = 3.2
Identities = 29/119 (24%), Positives = 44/119 (36%), Gaps = 9/119 (7%)
Query: 571 CPSPPALKDGF-VQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQ-- 627
C +PP +++ + V + + +P G+ V Y C Y + G+ C W C+
Sbjct: 1048 CVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNG-NW-TEPPQCKDS 1105
Query: 628 --KIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMK 684
K P+ I S P Y V C LEG C + +WS K
Sbjct: 1106 TGKCGPPPPIDNGDITSFPLS-VYAPASSVEYQCQNLYQLEGNKRITCRNG-QWSEPPK 1162
Score = 30.4 bits (67), Expect = 7.2
Identities = 12/31 (38%), Positives = 20/31 (64%)
Query: 575 PALKDGFVQDEGTMFPVGKNVVYTCNEGYSL 605
P L++G+ Q+ G F GK++ C+ GY+L
Sbjct: 392 PYLENGYNQNHGRKFVQGKSIDVACHPGYAL 422
>gi|133908621 perforin 1 precursor [Homo sapiens]
Length = 555
Score = 61.6 bits (148), Expect = 3e-09
Identities = 59/247 (23%), Positives = 96/247 (38%), Gaps = 21/247 (8%)
Query: 276 FWKELSHLPSLYDYS---AYRRLIDQYGTHYLQSGSLGGEYRVLFYVDSEKLKQNDFNSV 332
F + L LP ++ S AY RLI YGTH++++ LGG L + + +L
Sbjct: 193 FKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDN 252
Query: 333 EEKKC------KSSGWHFVVKFSSHGCKELENALKAASGTQNNVLRGEPFIRGGGAGFIS 386
E + C + G H + + C+E + K + + GG I+
Sbjct: 253 EVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSIN 312
Query: 387 GLSYLELDNPAGNKRRYSAWAESVTNLPQVIKQKLTPLYELVKEVPCASVKKLYLKWALE 446
L + P +YSAW S+ P ++ L PL+ L+ ++ L+ AL
Sbjct: 313 DLLFGIQAGP----EQYSAWVNSLPGSPGLVDYTLEPLHVLLDS---QDPRREALRRALS 365
Query: 447 EYLDE---FDPCHCRPCQNGGLATV-EGTHCLCHCKPYTFGAACEQGVLVGNQAGGVDGG 502
+YL + + C RPC G + + C+CH T C + +
Sbjct: 366 QYLTDRARWRDC-SRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQA 424
Query: 503 WSCWSSW 509
W W W
Sbjct: 425 WGLWGDW 431
>gi|40254808 perforin 1 precursor [Homo sapiens]
Length = 555
Score = 61.6 bits (148), Expect = 3e-09
Identities = 59/247 (23%), Positives = 96/247 (38%), Gaps = 21/247 (8%)
Query: 276 FWKELSHLPSLYDYS---AYRRLIDQYGTHYLQSGSLGGEYRVLFYVDSEKLKQNDFNSV 332
F + L LP ++ S AY RLI YGTH++++ LGG L + + +L
Sbjct: 193 FKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDN 252
Query: 333 EEKKC------KSSGWHFVVKFSSHGCKELENALKAASGTQNNVLRGEPFIRGGGAGFIS 386
E + C + G H + + C+E + K + + GG I+
Sbjct: 253 EVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSIN 312
Query: 387 GLSYLELDNPAGNKRRYSAWAESVTNLPQVIKQKLTPLYELVKEVPCASVKKLYLKWALE 446
L + P +YSAW S+ P ++ L PL+ L+ ++ L+ AL
Sbjct: 313 DLLFGIQAGP----EQYSAWVNSLPGSPGLVDYTLEPLHVLLDS---QDPRREALRRALS 365
Query: 447 EYLDE---FDPCHCRPCQNGGLATV-EGTHCLCHCKPYTFGAACEQGVLVGNQAGGVDGG 502
+YL + + C RPC G + + C+CH T C + +
Sbjct: 366 QYLTDRARWRDC-SRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQA 424
Query: 503 WSCWSSW 509
W W W
Sbjct: 425 WGLWGDW 431
>gi|4502503 complement component 4 binding protein, alpha chain
precursor [Homo sapiens]
Length = 597
Score = 60.1 bits (144), Expect = 8e-09
Identities = 38/150 (25%), Positives = 60/150 (40%), Gaps = 11/150 (7%)
Query: 536 VGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNV 595
+G TT + +D + L P C + C PP +++G E + G +V
Sbjct: 147 IGSTTSRCEVQDRGVGWSHPL-PQCEIVK------CKPPPDIRNGRHSGEENFYAYGFSV 199
Query: 596 VYTCNEGYSLIGNPVARCGEDLR----WLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTV 651
Y+C+ +SL+G+ C + W C+KI C P + G P Y
Sbjct: 200 TYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNY 259
Query: 652 GEKVTVSCSGGMSLEGPSAFLCGSSLKWSP 681
+ + C G L G S C + KW+P
Sbjct: 260 KDTIVFKCQKGFVLRGSSVIHCDADSKWNP 289
Score = 59.7 bits (143), Expect = 1e-08
Identities = 38/138 (27%), Positives = 55/138 (39%), Gaps = 20/138 (14%)
Query: 569 EFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQK 628
+ C PP + G + + + ++Y C++GY L+G C W C K
Sbjct: 424 DICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSCSYS-HWSAPAPQC-K 481
Query: 629 IACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARC 688
C P L++G S K Y E VT+ C G + GP + C + W PE
Sbjct: 482 ALCRKPELVNGRLS-VDKDQYVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPE------ 534
Query: 689 VQKENPLTQAVPKCQRWE 706
VPKC+ WE
Sbjct: 535 ----------VPKCE-WE 541
Score = 50.8 bits (120), Expect = 5e-06
Identities = 36/155 (23%), Positives = 67/155 (43%), Gaps = 13/155 (8%)
Query: 534 SCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGK 593
S +G + S E+E + R P C ++ C P V G ++
Sbjct: 208 SLLGHASISCTVENETIGVWRPSPPTCEKIT------CRKPDVSHGEMVSGFGPIYNYKD 261
Query: 594 NVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACV-LPVLMDGI-QSHP---QKPF 648
+V+ C +G+ L G+ V C D +W C+ +C+ LP + +++P ++
Sbjct: 262 TIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDV 321
Query: 649 YTVGEKVTVSCSGGM--SLEGPSAFLCGSSLKWSP 681
Y VG + C G + + P+ +C +L+W+P
Sbjct: 322 YVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTP 356
Score = 48.5 bits (114), Expect = 3e-05
Identities = 30/106 (28%), Positives = 50/106 (47%), Gaps = 4/106 (3%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC---GEDLRWLVGEMHCQ 627
C P L++G V+ + T G + ++C+EG+ LIG+ +RC + W C+
Sbjct: 113 CRHPGELRNGQVEIK-TDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCE 171
Query: 628 KIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC 673
+ C P + + ++ FY G VT SC SL G ++ C
Sbjct: 172 IVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISC 217
Score = 30.8 bits (68), Expect = 5.5
Identities = 40/147 (27%), Positives = 54/147 (36%), Gaps = 16/147 (10%)
Query: 571 CPSPPALKDGFVQD---EGTMFPVGKNVVYTCNEGY-SLIGNPVARCGEDLRWLVGEMHC 626
C PP L D T F G + YTC GY C D W V C
Sbjct: 50 CGPPPTLSFAAPMDITLTETRFKTGTTLKYTCLPGYVRSHSTQTLTCNSDGEW-VYNTFC 108
Query: 627 QKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNA 686
C P + Q K + G ++ SCS G L G + C E+++
Sbjct: 109 IYKRCRHPGELRNGQVE-IKTDLSFGSQIEFSCSEGFFLIGSTTSRC--------EVQD- 158
Query: 687 RCVQKENPLTQA-VPKCQRWEKLQNSR 712
R V +PL Q + KC+ ++N R
Sbjct: 159 RGVGWSHPLPQCEIVKCKPPPDIRNGR 185
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 60.1 bits (144), Expect = 8e-09
Identities = 26/51 (50%), Positives = 32/51 (62%), Gaps = 4/51 (7%)
Query: 499 VDGGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQC 545
VDG W W SWS C G+KTR R C++P P GGR C G+TT+ T+C
Sbjct: 4813 VDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRC 4863
Score = 55.1 bits (131), Expect = 3e-07
Identities = 25/56 (44%), Positives = 29/56 (51%), Gaps = 4/56 (7%)
Query: 494 NQAGGVDGGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQC 545
N+ VDG WS WS W C + G +TR+R CNNP GGR C G E C
Sbjct: 4580 NKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMC 4635
Score = 54.7 bits (130), Expect = 4e-07
Identities = 23/53 (43%), Positives = 29/53 (54%), Gaps = 4/53 (7%)
Query: 499 VDGGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQCED 547
V G WS W W C + G +TR+R CNNPPP+ GG C G T+ C +
Sbjct: 4642 VHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNE 4694
Score = 53.9 bits (128), Expect = 6e-07
Identities = 22/52 (42%), Positives = 30/52 (57%), Gaps = 4/52 (7%)
Query: 501 GGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQCEDE 548
G WS WS W C + G+ R R C+NPPPS GGR+C G ++ +C +
Sbjct: 4758 GNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTD 4809
Score = 51.6 bits (122), Expect = 3e-06
Identities = 35/118 (29%), Positives = 51/118 (43%), Gaps = 24/118 (20%)
Query: 455 CHCRPCQNGGLATV------------EGTHC---LCHCKPYTFGAA----CEQGVLVGNQ 495
C+ RPC G + +GT LC+ P FG + E + V N+
Sbjct: 4635 CNIRPCPVHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNE 4694
Query: 496 AG-GVDGGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQCEDE 548
+ G W+ W+SWS C G + R+R C++P P GGR C G +S C +
Sbjct: 4695 RNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSD 4752
Score = 49.3 bits (116), Expect = 1e-05
Identities = 22/54 (40%), Positives = 31/54 (57%), Gaps = 4/54 (7%)
Query: 499 VDGGWSCWSSWSPCV----QGKKTRSRECNNPPPSGGGRSCVGETTESTQCEDE 548
V GG+S WS+W C +G + RSR CN P P+ GG+ C G E C+++
Sbjct: 4528 VHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNK 4581
Score = 40.4 bits (93), Expect = 0.007
Identities = 25/69 (36%), Positives = 35/69 (50%), Gaps = 4/69 (5%)
Query: 15 EFQSFSSASSPVNCQWDFYAPWSECN-GCTK-TQTRRRSVAVYG-QYGGQPCVGNAFETQ 71
E ++ + PV+ W ++ W EC C + QTR R+ Q+GG+PC GNA E
Sbjct: 4574 EMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEII 4633
Query: 72 SCEPTRGCP 80
C R CP
Sbjct: 4634 MCN-IRPCP 4641
Score = 39.3 bits (90), Expect = 0.015
Identities = 32/121 (26%), Positives = 50/121 (41%), Gaps = 18/121 (14%)
Query: 15 EFQSFSSASSPVNCQWDFYAPWS----ECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFET 70
+ Q + + P++ +W +A WS C G + +TR S V QYGG+ C G+ ++
Sbjct: 4688 QMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPV-PQYGGRKCEGSDVQS 4746
Query: 71 QSCEPTRGCPTE------EGCGERFRCFSGQCISKSLVC------NGDSDCDEDSADEDR 118
C + CPT G G R +G + + C NG C + R
Sbjct: 4747 DFCN-SDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQR 4805
Query: 119 C 119
C
Sbjct: 4806 C 4806
Score = 32.3 bits (72), Expect = 1.9
Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 4/59 (6%)
Query: 25 PVNCQWDFYAPWSECN-GCTK-TQTRRRSV-AVYGQYGGQPCVGNAFETQSCEPTRGCP 80
PV+ W + PW C+ C K TQTR R +GG C G + Q C R CP
Sbjct: 4641 PVHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCN-ERNCP 4698
Score = 32.0 bits (71), Expect = 2.5
Identities = 20/70 (28%), Positives = 33/70 (47%), Gaps = 6/70 (8%)
Query: 15 EFQSFSSASSPVNCQWDFYAPWSECN----GCTKTQTRRRSVAVYGQYGGQPCVGNAFET 70
+ Q ++ PV+ W + WS+C+ G KT+ R V + GG+PC G+ +
Sbjct: 4802 QIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVK-GGRPCPGDTTQV 4860
Query: 71 QSCEPTRGCP 80
C + CP
Sbjct: 4861 TRCN-VQACP 4869
>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
Length = 1170
Score = 59.7 bits (143), Expect = 1e-08
Identities = 36/110 (32%), Positives = 47/110 (42%), Gaps = 24/110 (21%)
Query: 499 VDGGWSCWSSWS----PCVQGKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLR 554
++GGW WS W C G + RSR CNNP P GG+ CVG+ TE+ C ++
Sbjct: 491 INGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQD----- 545
Query: 555 LLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYS 604
P + C S P F + T +P G C GYS
Sbjct: 546 -----------CPIDGCLSNPC----FAGVKCTSYPDGSWKCGACPPGYS 580
Score = 53.1 bits (126), Expect = 1e-06
Identities = 24/53 (45%), Positives = 29/53 (54%), Gaps = 4/53 (7%)
Query: 500 DGGWSCWSSWSPCV----QGKKTRSRECNNPPPSGGGRSCVGETTESTQCEDE 548
DGGWS WS WS C G TR R CN+P P G+ C GE E+ C+ +
Sbjct: 435 DGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKD 487
Score = 41.2 bits (95), Expect = 0.004
Identities = 35/141 (24%), Positives = 58/141 (41%), Gaps = 30/141 (21%)
Query: 15 EFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYG---QYGGQPCVGNAFETQ 71
E ++ + P+N W ++PW C+ ++RS Q+GG+ CVG+ E Q
Sbjct: 480 ETKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQ 539
Query: 72 SCEPTRGCPTEEGCGERFRCFSG-QCIS-----------------KSLVCNGDSDCDE-- 111
C + CP +GC CF+G +C S + C +C E
Sbjct: 540 ICN-KQDCPI-DGCLSN-PCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDECKEVP 596
Query: 112 ----DSADEDRCEDSERRPSC 128
+ E RCE+++ +C
Sbjct: 597 DACFNHNGEHRCENTDPGYNC 617
Score = 39.3 bits (90), Expect = 0.015
Identities = 33/118 (27%), Positives = 45/118 (38%), Gaps = 22/118 (18%)
Query: 30 WDFYAPWSECN---GCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPTRGCPTEEGCG 86
W ++PWS C+ G R + Q G+PC G A ET++C+ CP G G
Sbjct: 438 WSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKD-ACPINGGWG 496
Query: 87 E-------RFRCFSGQCISKSLVCN------GDSDCDEDSADEDRCEDSERRPSCDID 131
C G +S +CN G DC D + C + C ID
Sbjct: 497 PWSPWDICSVTC-GGGVQKRSRLCNNPTPQFGGKDCVGDVTENQIC----NKQDCPID 549
Score = 38.5 bits (88), Expect = 0.026
Identities = 46/210 (21%), Positives = 72/210 (34%), Gaps = 50/210 (23%)
Query: 368 NNVLRGE-PFIRGGGAGF-------ISGLSYLELDNPAGNKRRYSAWAESVTNLPQVIKQ 419
NNV+ G P IR G I G+S EL + R ++ + + + +
Sbjct: 244 NNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDSIRKVTE 303
Query: 420 KLTPLYELVKEVPCASVKKLYLKWALEEYLDEFDPCHCR--------------PCQNGGL 465
+ L ++ P + + E +D CHC+ PC N
Sbjct: 304 ENKELANELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSN--- 360
Query: 466 ATVEGTHCLCHCKPYTFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCV----QGKKTRSR 521
ATV C C P + D GWS WS W+ C G + R R
Sbjct: 361 ATVPDGECCPRCWP----------------SDSADDGWSPWSEWTSCSTSCGNGIQQRGR 404
Query: 522 ECNNPPPSGGGRSCVGETTESTQCEDEELE 551
C++ C G + ++ C +E +
Sbjct: 405 SCDSL-----NNRCEGSSVQTRTCHIQECD 429
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 59.3 bits (142), Expect = 1e-08
Identities = 30/96 (31%), Positives = 45/96 (46%), Gaps = 9/96 (9%)
Query: 460 CQNGGLATVEGTHCLCHC--KPYTFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQ--- 514
C + EGT C H K + + C V G++ GVDG W W+ W C +
Sbjct: 508 CITNSIPAAEGTLCQTHTIDKGWCYKRVC---VPFGSRPEGVDGAWGPWTPWGDCSRTCG 564
Query: 515 -GKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEE 549
G + SR C++P P+ GG+ C+GE C ++
Sbjct: 565 GGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDD 600
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 59.3 bits (142), Expect = 1e-08
Identities = 27/59 (45%), Positives = 34/59 (57%), Gaps = 4/59 (6%)
Query: 495 QAGGVDGGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEE 549
Q G DGGWS W+ + C + G ++RSR CNNP P+ GGR C+G E C EE
Sbjct: 547 QTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEE 605
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1
motif, 14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 59.3 bits (142), Expect = 1e-08
Identities = 27/59 (45%), Positives = 34/59 (57%), Gaps = 4/59 (6%)
Query: 495 QAGGVDGGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEE 549
Q G DGGWS W+ + C + G ++RSR CNNP P+ GGR C+G E C EE
Sbjct: 550 QTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEE 608
>gi|32261318 unc-5 homolog B [Homo sapiens]
Length = 945
Score = 58.5 bits (140), Expect = 2e-08
Identities = 35/94 (37%), Positives = 40/94 (42%), Gaps = 5/94 (5%)
Query: 459 PCQNG-GLATVEGTHCLCHCKPYTFGAACEQGVLVGNQAGG---VDGGWSCWSSWSPC-V 513
PC N G + T + P GA CE VDG W+ WS WS C
Sbjct: 257 PCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVDGAWTEWSKWSACST 316
Query: 514 QGKKTRSRECNNPPPSGGGRSCVGETTESTQCED 547
+ RSREC PPP GGR C G +S C D
Sbjct: 317 ECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTD 350
Score = 56.2 bits (134), Expect = 1e-07
Identities = 23/51 (45%), Positives = 30/51 (58%), Gaps = 4/51 (7%)
Query: 499 VDGGWSCWSSWSPCV----QGKKTRSRECNNPPPSGGGRSCVGETTESTQC 545
V+GGWS W+ WSPC +G + R+R C NP P GG C G+ + T C
Sbjct: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTAC 295
Score = 37.4 bits (85), Expect = 0.059
Identities = 32/108 (29%), Positives = 42/108 (38%), Gaps = 14/108 (12%)
Query: 26 VNCQWDFYAPWSEC-NGCTKTQTRRRSVAVYGQ--YGGQPCVGNAFETQSCEPTRGCPTE 82
VN W +A WS C N C + +R GG C G AF+ +C T CP +
Sbjct: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTAC--TTICPVD 302
Query: 83 EGCGE--RFRCFSGQCIS-KSLVC------NGDSDCDEDSADEDRCED 121
E ++ S +C +S C NG DC D C D
Sbjct: 303 GAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTD 350
Score = 31.6 bits (70), Expect = 3.2
Identities = 14/49 (28%), Positives = 24/49 (48%)
Query: 25 PVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSC 73
PV+ W ++ WS C+ R +A Q GG+ C G ++++C
Sbjct: 300 PVDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNC 348
>gi|40317628 thrombospondin 2 precursor [Homo sapiens]
Length = 1172
Score = 58.5 bits (140), Expect = 2e-08
Identities = 27/68 (39%), Positives = 34/68 (50%), Gaps = 4/68 (5%)
Query: 499 VDGGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLR 554
+DG WS WS WS C G + R+R CN+P P GG++CVG+ E C
Sbjct: 493 IDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDG 552
Query: 555 LLEPHCFP 562
L CFP
Sbjct: 553 CLSNPCFP 560
Score = 53.1 bits (126), Expect = 1e-06
Identities = 24/51 (47%), Positives = 29/51 (56%), Gaps = 4/51 (7%)
Query: 500 DGGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQCE 546
DGGWS WS WS C G TR R CN+P P GG++C G E+ C+
Sbjct: 437 DGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQ 487
Score = 49.3 bits (116), Expect = 1e-05
Identities = 41/137 (29%), Positives = 57/137 (41%), Gaps = 21/137 (15%)
Query: 15 EFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYG---QYGGQPCVGNAFETQ 71
E ++ A P++ +W ++PWS C R R+ QYGG+ CVG+ E Q
Sbjct: 482 ETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQ 541
Query: 72 SCEPTRGCPTEEGCGERFRCFSG-QCIS------------KSLVCNGD--SDCDEDSADE 116
C R CP +GC CF G QC S + NG D DE +
Sbjct: 542 MCN-KRSCPV-DGCLSN-PCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVP 598
Query: 117 DRCEDSERRPSCDIDKP 133
D C + + P C +P
Sbjct: 599 DICFSTSKVPRCVNTQP 615
Score = 33.9 bits (76), Expect = 0.65
Identities = 29/117 (24%), Positives = 44/117 (37%), Gaps = 20/117 (17%)
Query: 30 WDFYAPWSECN---GCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPT------RGCP 80
W ++PWS C+ G R + Q GG+ C G+ ET++C+ R P
Sbjct: 440 WSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSP 499
Query: 81 TEEGCGERFRCFSGQCISKSLVCN------GDSDCDEDSADEDRCEDSERRPSCDID 131
C +G ++ VCN G C D + C + SC +D
Sbjct: 500 WSPWSACTVTC-AGGIRERTRVCNSPEPQYGGKACVGDVQERQMC----NKRSCPVD 551
Score = 32.0 bits (71), Expect = 2.5
Identities = 22/82 (26%), Positives = 36/82 (43%), Gaps = 15/82 (18%)
Query: 474 LCH---CKPYTFGA-ACEQGVLVGNQAGGVDG--GWSCWSSWSPCV----QGKKTRSREC 523
+CH C P T + + +G + VDG GWS W+ W+ C G + R R C
Sbjct: 349 ICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSC 408
Query: 524 NNPPPSGGGRSCVGETTESTQC 545
+ +C+G + ++ C
Sbjct: 409 DVT-----SNTCLGPSIQTRAC 425
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 58.2 bits (139), Expect = 3e-08
Identities = 37/132 (28%), Positives = 55/132 (41%), Gaps = 20/132 (15%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIA 630
C SP + +G + +G F VVY CN G+ L+G V C +D +W C I
Sbjct: 2681 CGSPDPIVNGHISGDG--FSYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPIT 2738
Query: 631 CVLPVLMDGIQSHPQKPF--------YTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPE 682
C HP P + + + V +C+ G L+G S C S+ +WS
Sbjct: 2739 C----------GHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSP 2788
Query: 683 MKNARCVQKENP 694
+ R V +P
Sbjct: 2789 LPTCRVVNCSDP 2800
Score = 51.2 bits (121), Expect = 4e-06
Identities = 28/95 (29%), Positives = 42/95 (44%), Gaps = 2/95 (2%)
Query: 586 GTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQ 645
GT+ G ++TCN GY+L+G+ V C + W E C C P + + H
Sbjct: 2636 GTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSPDPI--VNGHIS 2693
Query: 646 KPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWS 680
++ + V C+ G L G S +C KWS
Sbjct: 2694 GDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWS 2728
Score = 49.7 bits (117), Expect = 1e-05
Identities = 36/140 (25%), Positives = 56/140 (40%), Gaps = 11/140 (7%)
Query: 558 PHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDL 617
P C P++ C P GF G+ F + V +TCN GY L G A+C +
Sbjct: 2732 PVCVPIT------CGHPGNPAHGFTN--GSEFNLNDVVNFTCNTGYLLQGVSRAQCRSNG 2783
Query: 618 RWLVGEMHCQKIACVLPVLMDGIQSHPQKPF---YTVGEKVTVSCSGGMSLEGPSAFLCG 674
+W C+ + C P ++ H Q+ F + G + C G L G SA C
Sbjct: 2784 QWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCM 2843
Query: 675 SSLKWSPEMKNARCVQKENP 694
++ W + + +P
Sbjct: 2844 ANGLWDRSLPKCLAISCGHP 2863
Score = 43.9 bits (102), Expect = 6e-04
Identities = 29/110 (26%), Positives = 46/110 (41%), Gaps = 4/110 (3%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIA 630
CP PP +++G V EG+ F G ++ Y+C +GY L + + C W C +
Sbjct: 3098 CPQPPPVQNGTV--EGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPVF 3155
Query: 631 CVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWS 680
C P + + +T +V C L G S +C + WS
Sbjct: 3156 CGDPGI--PAEGRLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWS 3203
Score = 42.4 bits (98), Expect = 0.002
Identities = 37/143 (25%), Positives = 57/143 (39%), Gaps = 15/143 (10%)
Query: 556 LEPHCFPLSLVPTEFCPSPPALKDGF-VQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCG 614
L+P C +S C +P +G V +G +F +V+Y C EGY G C
Sbjct: 2970 LQPVCEAVS------CGNPGTPTNGMIVSSDGILF--SSSVIYACWEGYKTSGLMTRHCT 3021
Query: 615 EDLRWLVGEMHCQKIACVLP-VLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEG--PSAF 671
+ W C I+C P L +GIQ +T + V+ C+ G +E +
Sbjct: 3022 ANGTWTGTAPDCTIISCGDPGTLANGIQFGTD---FTFNKTVSYQCNPGYVMEAVTSATI 3078
Query: 672 LCGSSLKWSPEMKNARCVQKENP 694
C +W+P + V P
Sbjct: 3079 RCTKDGRWNPSKPVCKAVLCPQP 3101
Score = 41.2 bits (95), Expect = 0.004
Identities = 30/120 (25%), Positives = 46/120 (38%), Gaps = 21/120 (17%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIA 630
CP P G +Q+ + VG V + C +GY + G+ C +L W + C A
Sbjct: 3217 CPDPGTPHFG-IQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHA 3275
Query: 631 CVLPVLMDGIQSHPQKPFY---------TVGEKVTVSCSGGMSLEGPSAF-LCGSSLKWS 680
C P+ P + T G + +C G L G S C + +KW+
Sbjct: 3276 C----------RQPETPAHADVRAIDLPTFGYTLVYTCHPGFFLAGGSEHRTCKADMKWT 3325
Score = 40.8 bits (94), Expect = 0.005
Identities = 68/291 (23%), Positives = 103/291 (35%), Gaps = 76/291 (26%)
Query: 438 KLYLKWALEEYLDE------FDPCHC---RPCQNGGL----ATVEGTHCLCHCKP-YTF- 482
+LYL+W+ + + + +C P +NGG+ A G+ CKP Y
Sbjct: 2408 QLYLRWSTDHATSKKGFKIRYAAPYCSLTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMV 2467
Query: 483 ---GAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTRSRECNNPPPSGGGRSCVGET 539
A C + L G W S +P Q C P G G E
Sbjct: 2468 GHSNATCRRNPL----------GMYQWDSLTPLCQAVS-----CGIPESPGNGSFTGNEF 2512
Query: 540 T---------------ESTQ-----CEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKD 579
T ES+Q C+++ L + P C P++ CPS A
Sbjct: 2513 TLDSKVVYECHEGFKLESSQQATAVCQEDGLWSNKGKPPTCKPVA------CPSIEAQLS 2566
Query: 580 GFV---QDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMH--CQKIACVLP 634
V G++ G V+ +C+ GY L G + RC + W +G+ C+ I+C
Sbjct: 2567 EHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISC--- 2623
Query: 635 VLMDGIQSHPQK-----PFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWS 680
G S P G +C+ G +L G C ++ WS
Sbjct: 2624 ----GSLSFPPNGNKIGTLTVYGATAIFTCNTGYTLVGSHVRECLANGLWS 2670
Score = 40.4 bits (93), Expect = 0.007
Identities = 17/43 (39%), Positives = 27/43 (62%), Gaps = 2/43 (4%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC 613
CP PP ++G++ + + VG++V + C GY LIG+PV C
Sbjct: 2088 CPDPPPFQNGYMINSD--YSVGQSVSFECYPGYILIGHPVLTC 2128
Score = 36.6 bits (83), Expect = 0.10
Identities = 15/43 (34%), Positives = 22/43 (51%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC 613
C PPA+ + E F +G V Y C+ GY+L+G + C
Sbjct: 2259 CQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTC 2301
Score = 36.2 bits (82), Expect = 0.13
Identities = 33/116 (28%), Positives = 40/116 (34%), Gaps = 9/116 (7%)
Query: 586 GTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHC---QKIACVLPVLMDGIQS 642
G +F G V Y+C SLIGN C ED W HC C P G +
Sbjct: 2873 GELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDP----GTPA 2928
Query: 643 HPQK--PFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLT 696
H + + + SC G L G C + WS V NP T
Sbjct: 2929 HGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGT 2984
Score = 33.5 bits (75), Expect = 0.85
Identities = 15/49 (30%), Positives = 26/49 (53%), Gaps = 2/49 (4%)
Query: 565 LVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC 613
++P+ C +P + G + GT F +G + Y+C GY L G+ + C
Sbjct: 139 VLPSHTCGNPGEILKGVLH--GTRFNIGDKIRYSCLPGYILEGHAILTC 185
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 57.8 bits (138), Expect = 4e-08
Identities = 32/99 (32%), Positives = 42/99 (42%), Gaps = 10/99 (10%)
Query: 455 CHCRPCQNGGLATVEGTHCLCHCKPYTFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQ 514
C C Q+GG C + GA ++ VDG W W WSPC
Sbjct: 3435 CACPTPQHGGAP--------CTGEAGEAGAQHQREACPSYATCPVDGAWGPWGPWSPCDM 3486
Query: 515 --GKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEELE 551
G+ RSR C+ PP GGR C G T+S C++ +
Sbjct: 3487 CLGQSHRSRACSRPPTPEGGRPCPGNHTQSRPCQENSTQ 3525
Score = 53.5 bits (127), Expect = 8e-07
Identities = 59/251 (23%), Positives = 82/251 (32%), Gaps = 49/251 (19%)
Query: 499 VDGGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQCED------- 547
V GGWS WS WS C + G+ RSR C++PP GG C GE ++ C
Sbjct: 4003 VPGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCNPMPCEAGC 4062
Query: 548 ----EELEHLRLLEPHCFPLS----LVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTC 599
E + C L + C G ++ +G P+G + T
Sbjct: 4063 PAGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQKGCRCPKGSLEQDGGCVPIG-HCDCTD 4121
Query: 600 NEGYSLIGNPVARCGEDLRWLVGEMH---CQKIACVLPVLMDGIQSHPQKPFYTVGEKVT 656
+G+S W G H C +C L Q P
Sbjct: 4122 AQGHS--------------WAPGSQHQDACNNCSCQAGQLSCTAQPCPPPTHCAWSHWSA 4167
Query: 657 VS-CSGGMSLEG-PSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKC----------QR 704
S CS G S F +S W+PE + + + P P C
Sbjct: 4168 WSPCSHSCGPRGQQSRFRSSTSGSWAPECREEQSQSQPCPQPSCPPLCLQGTRSRTLGDS 4227
Query: 705 WEKLQNSRCVC 715
W + + RC C
Sbjct: 4228 WLQGECQRCSC 4238
Score = 53.1 bits (126), Expect = 1e-06
Identities = 82/375 (21%), Positives = 124/375 (33%), Gaps = 90/375 (24%)
Query: 495 QAGGVDGGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQC----- 545
QA V G W+ W +W PC G ++R R C +PPP GG C G + E C
Sbjct: 2550 QACPVAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPCGLQPC 2609
Query: 546 ---EDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQD-------EGTMFPVGKNV 595
D EL + + C LVP P PP+ D EG P G +
Sbjct: 2610 SGGTDCELGRVYVSADLC-QKGLVP----PCPPSCLDPKANRSCSGHCVEGCRCPPGLLL 2664
Query: 596 VYTCNEGYSLIGNPVARC----GEDLRW---------------LVGEMHCQKIACVLPV- 635
+ P++ C GE+L+W GE+ CQ C LP
Sbjct: 2665 -------HDTRCLPLSECPCLVGEELKWPGVSFLLGNCSQCVCEKGELLCQPGGCPLPCG 2717
Query: 636 -------------LMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSL-KWSP 681
G+++ + P C G +CG+ + W+P
Sbjct: 2718 WSAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGCHTVCGTEVFGWTP 2777
Query: 682 EMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYECGPSLDVCAQDERSKRILPL- 740
+ C Q A W +C P + D ++ S + P+
Sbjct: 2778 WTSWSSCSQS----CLAPGGGPGWRSRSR---LCPSPGDSSCPGDATQEEPCSPPVCPVP 2830
Query: 741 ---------TVCKMHV---LHCQGRNYT--LTGRDSCTLPASAEKACGACPLWGKCDAES 786
+ C + +GR+ + G +C P S + C P +C
Sbjct: 2831 SIWGLWAPWSTCSAPCDGGIQTRGRSCSSLAPGDTTCPGPHSQTRDCNTQPCTAQC---P 2887
Query: 787 SKCVCREASECEEEG 801
+ R A +C +EG
Sbjct: 2888 ENMLFRSAEQCHQEG 2902
Score = 51.6 bits (122), Expect = 3e-06
Identities = 26/65 (40%), Positives = 35/65 (53%), Gaps = 5/65 (7%)
Query: 486 CEQGVLVGNQAG-GVDGGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETT 540
CE+G L+ G + GWS WSSW+PC + G + R R +NPP + GG C G+
Sbjct: 2700 CEKGELLCQPGGCPLPCGWSAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQ 2759
Query: 541 ESTQC 545
E C
Sbjct: 2760 ELQGC 2764
Score = 49.7 bits (117), Expect = 1e-05
Identities = 24/58 (41%), Positives = 31/58 (53%), Gaps = 5/58 (8%)
Query: 499 VDGGWSCWSSWSPCV-----QGKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEELE 551
VD GWS WS W+ C+ Q + R NNP PSG GR C G ++ +C+ E E
Sbjct: 1908 VDCGWSSWSPWAKCLGPCGSQSIQWSFRSSNNPRPSGRGRQCRGIHRKARRCQTEPCE 1965
Score = 46.6 bits (109), Expect = 1e-04
Identities = 19/50 (38%), Positives = 26/50 (52%), Gaps = 4/50 (8%)
Query: 501 GGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQCE 546
GGW W WS C + G ++R+R C+ PPP G G C G + C+
Sbjct: 3253 GGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEVCQ 3302
Score = 46.6 bits (109), Expect = 1e-04
Identities = 35/118 (29%), Positives = 44/118 (37%), Gaps = 37/118 (31%)
Query: 455 CHCRPCQ---NGGLATVEGTHCLC----------------------HCKPYTFGAACEQG 489
C+C P Q + G V+ HC C HC C +G
Sbjct: 3344 CYCPPGQVLSSNGAICVQPGHCSCLDLLTGQRHHPGARLARPDGCNHC-------TCLEG 3396
Query: 490 VL-VGNQAGGVDGGWSCWSSWS----PCVQGKKTRSRECNNPPPSGGGRSCVGETTES 542
L + V GGW WS W+ PC ++RSR C P P GG C GE E+
Sbjct: 3397 RLNCTDLPCPVPGGWCPWSEWTMCSQPCRGQTRSRSRACACPTPQHGGAPCTGEAGEA 3454
Score = 45.8 bits (107), Expect = 2e-04
Identities = 29/81 (35%), Positives = 36/81 (44%), Gaps = 16/81 (19%)
Query: 458 RPCQNGGLATVEGTHCLCHCKPYTFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQ--- 514
R C GL ++ H F AAC VDG WS WS WS C +
Sbjct: 1719 RRCSPLGLLVLQNCPGPEHQSQACFTAACP-----------VDGEWSTWSPWSVCSEPCR 1767
Query: 515 GKKTRSRECNNPPPSGGGRSC 535
G TR R+C++ P GGR+C
Sbjct: 1768 GTMTRQRQCHS--PQNGGRTC 1786
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/118 (26%), Positives = 51/118 (43%), Gaps = 16/118 (13%)
Query: 17 QSFSSASSPVNCQWDFYAPWSECN-GCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEP 75
Q+ +A+ PV+ +W ++PWS C+ C T TR+R Q GG+ C S
Sbjct: 1740 QACFTAACPVDGEWSTWSPWSVCSEPCRGTMTRQRQ-CHSPQNGGRTCAALPGGLHSTRQ 1798
Query: 76 TRGCPTEEGCGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCEDSERRPSCDIDKP 133
T+ CP ++GC + C+G+ + C+D + +C D P
Sbjct: 1799 TKPCP-QDGC-------------PNATCSGELMFQPCAPCPLTCDDISGQVTCPPDWP 1842
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/118 (28%), Positives = 47/118 (39%), Gaps = 24/118 (20%)
Query: 443 WALE--EYLDEFDPC---HCRP-CQNG------GLATVEGTHCLCHCKPYTFGAACEQGV 490
WA E E + PC C P C G G + ++G C C P +GV
Sbjct: 4192 WAPECREEQSQSQPCPQPSCPPLCLQGTRSRTLGDSWLQGECQRCSCTP--------EGV 4243
Query: 491 LVGNQAGGVDGGWSCWSSWSPCV----QGKKTRSRECNNPPPSGGGRSCVGETTESTQ 544
+ + V W+ WSSWS C G + R+R C P C+G T++ Q
Sbjct: 4244 ICEDTECAVPEAWTLWSSWSDCPVSCGGGNQVRTRACRAAAPHHRSPPCLGPDTQTRQ 4301
Score = 40.8 bits (94), Expect = 0.005
Identities = 22/69 (31%), Positives = 35/69 (50%), Gaps = 1/69 (1%)
Query: 20 SSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVA-VYGQYGGQPCVGNAFETQSCEPTRG 78
S A+ PV+ W + PWS C+ C R R+ + GG+PC GN +++ C+
Sbjct: 3465 SYATCPVDGAWGPWGPWSPCDMCLGQSHRSRACSRPPTPEGGRPCPGNHTQSRPCQENST 3524
Query: 79 CPTEEGCGE 87
T+ G G+
Sbjct: 3525 QCTDCGGGQ 3533
Score = 39.7 bits (91), Expect = 0.012
Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 5/43 (11%)
Query: 500 DGGWSCWSSWSPCVQ-----GKKTRSRECNNPPPSGGGRSCVG 537
DGG+ WS W PC + G +TRSR+C P+ G+ C G
Sbjct: 3811 DGGFGPWSPWGPCSRSCGGLGTRTRSRQCVLTMPTLSGQGCRG 3853
Score = 39.7 bits (91), Expect = 0.012
Identities = 26/98 (26%), Positives = 41/98 (41%), Gaps = 14/98 (14%)
Query: 25 PVNCQWDFYAPWSECN---GCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPTRGCPT 81
PV W ++PWS C+ G ++ R + + GG PC G + + C P P
Sbjct: 4002 PVPGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCNP---MPC 4058
Query: 82 EEGC--GERFRCFSGQC------ISKSLVCNGDSDCDE 111
E GC G + +C + + +VC D C +
Sbjct: 4059 EAGCPAGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQK 4096
Score = 39.3 bits (90), Expect = 0.015
Identities = 22/52 (42%), Positives = 28/52 (53%), Gaps = 4/52 (7%)
Query: 69 ETQSCEPTRGCPTEEGC-GERFRCFSGQCISKSLVCNGDSDCDEDSADEDRC 119
E CEP G P C G RC SG+C+ + C+G DC ED +DE+ C
Sbjct: 2220 ELLGCEP--GSPPAPLCPGVGLRCASGECVLRGGPCDGVLDC-EDGSDEEGC 2268
Score = 39.3 bits (90), Expect = 0.015
Identities = 22/64 (34%), Positives = 30/64 (46%), Gaps = 3/64 (4%)
Query: 25 PVNCQWDFYAPWSECNGCTKTQTRRRSVAVY---GQYGGQPCVGNAFETQSCEPTRGCPT 81
PV W ++ W+ C+ + QTR RS A Q+GG PC G A E + CP+
Sbjct: 3406 PVPGGWCPWSEWTMCSQPCRGQTRSRSRACACPTPQHGGAPCTGEAGEAGAQHQREACPS 3465
Query: 82 EEGC 85
C
Sbjct: 3466 YATC 3469
Score = 38.9 bits (89), Expect = 0.020
Identities = 30/112 (26%), Positives = 46/112 (41%), Gaps = 19/112 (16%)
Query: 25 PVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQ---YGGQPCVGNAFETQSCEPTRGCPT 81
P+ C W ++ W+ C+ + R R + +GG PC G+ E Q C C T
Sbjct: 2713 PLPCGWSAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGCHTV--CGT 2770
Query: 82 EEGCGERFRCFSG---QCI---------SKSLVC--NGDSDCDEDSADEDRC 119
E + +S C+ S+S +C GDS C D+ E+ C
Sbjct: 2771 EVFGWTPWTSWSSCSQSCLAPGGGPGWRSRSRLCPSPGDSSCPGDATQEEPC 2822
Score = 37.7 bits (86), Expect = 0.045
Identities = 19/48 (39%), Positives = 23/48 (47%), Gaps = 4/48 (8%)
Query: 502 GWSCWSSWS----PCVQGKKTRSRECNNPPPSGGGRSCVGETTESTQC 545
GWS W+ WS C G + R R PP + GG C G T E+ C
Sbjct: 2987 GWSPWTLWSLCSCSCNVGIRRRFRAGTAPPAAFGGAECQGPTMEAEFC 3034
Score = 37.4 bits (85), Expect = 0.059
Identities = 25/77 (32%), Positives = 33/77 (42%), Gaps = 15/77 (19%)
Query: 498 GVDGGWSCWSSWSPCVQGKKTRSRECNNPP-PSGGGRS--CVGETTESTQCEDEELEHLR 554
G+ GGW WSSWSPC SR C +P P+ R+ C+ T + L+
Sbjct: 3878 GLPGGWGPWSSWSPC-------SRSCTDPARPAWRSRTRLCLANCTMG-----DPLQERP 3925
Query: 555 LLEPHCFPLSLVPTEFC 571
P C L + P C
Sbjct: 3926 CNLPSCTELPVCPGPGC 3942
Score = 36.2 bits (82), Expect = 0.13
Identities = 22/68 (32%), Positives = 27/68 (39%), Gaps = 4/68 (5%)
Query: 20 SSASSPVNCQWDFYAPWSECNGCTKTQTRRR---SVAVYGQYGGQPCVGNAFETQSCEPT 76
+S PV C W + WS C+ RRR A +GG C G E + C
Sbjct: 2978 TSERCPVACGWSPWTLWSLCSCSCNVGIRRRFRAGTAPPAAFGGAECQGPTMEAEFCS-L 3036
Query: 77 RGCPTEEG 84
R CP G
Sbjct: 3037 RPCPGPGG 3044
Score = 35.0 bits (79), Expect = 0.29
Identities = 18/46 (39%), Positives = 27/46 (58%), Gaps = 6/46 (13%)
Query: 74 EPTRGCPTEEGCGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRC 119
EP+ CP +G C G+C+ +L+C+G DC D+ADE+ C
Sbjct: 1447 EPSYPCP--QGL---LACADGRCLPPALLCDGHPDC-LDAADEESC 1486
Score = 34.7 bits (78), Expect = 0.38
Identities = 17/52 (32%), Positives = 22/52 (42%), Gaps = 7/52 (13%)
Query: 501 GGWSCWSSWSPCVQ----GKKTRSRECNNPP---PSGGGRSCVGETTESTQC 545
G WS W W C G++ RSR C PP P+ R+C + C
Sbjct: 3646 GVWSSWGPWEDCSVSCGGGEQLRSRRCARPPCPGPARQSRTCSTQVCREAGC 3697
Score = 33.9 bits (76), Expect = 0.65
Identities = 21/75 (28%), Positives = 30/75 (40%), Gaps = 14/75 (18%)
Query: 473 CLCHC--------KPYTFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQ----GKKTRS 520
CL +C +P + E V G G + W+ W+ W PC + G++ R
Sbjct: 3911 CLANCTMGDPLQERPCNLPSCTELPVCPGPGCGAGNCSWTSWAPWEPCSRSCGVGQQRRL 3970
Query: 521 RECNNPPPSGGGRSC 535
R PP GG C
Sbjct: 3971 RAYR--PPGPGGHWC 3983
Score = 33.1 bits (74), Expect = 1.1
Identities = 55/236 (23%), Positives = 74/236 (31%), Gaps = 57/236 (24%)
Query: 430 EVPCASVKKLYLKWALEEYLDEFDPCHCRPCQNGGLA-TVEGTHCLCHCKPYTFGAACEQ 488
+ PC +LY A+ D C+ C +G +A T E C P+T + C
Sbjct: 2944 QCPCQLHGQLYASGAMAR----LDSCNNCTCVSGKMACTSERCPVACGWSPWTLWSLCSC 2999
Query: 489 GVLVGNQ----AGGVD----GGWSC---------------------WSSWSPCV----QG 515
VG + AG GG C W WSPC G
Sbjct: 3000 SCNVGIRRRFRAGTAPPAAFGGAECQGPTMEAEFCSLRPCPGPGGEWGPWSPCSVPCGGG 3059
Query: 516 KKTRSR----------ECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSL 565
+ R+R C P +G + C L P +
Sbjct: 3060 YRNRTRGSSRSLMEFSTCGLQPCAGPVPGMCPRDKQWLDCAQGPASCAELSAPRGTNQTC 3119
Query: 566 VPTEFCPSPPALKDGF---VQD-----EGTMFPVGKNVVYTCNEGYSLIGNPVARC 613
P CPS L + QD EG ++P G VV C E S + +A C
Sbjct: 3120 HPGCHCPSGMLLLNNVCVPTQDCPCAHEGHLYPPGSTVVRPC-ENCSCVSGLIANC 3174
Score = 33.1 bits (74), Expect = 1.1
Identities = 21/58 (36%), Positives = 26/58 (44%), Gaps = 4/58 (6%)
Query: 488 QGVLVGNQAGGVDGGWSCWSSWS-PCVQGKKTRSRECNNPPPSGGGRSCVGETTESTQ 544
+ ++ +Q V G WS WSS S PC G R R C P G C + TE Q
Sbjct: 4754 ESLVCPHQECPVLGPWSAWSSCSAPCGGGTMERHRTCEGGP---GVAPCQAQDTEQRQ 4808
Score = 32.7 bits (73), Expect = 1.4
Identities = 17/40 (42%), Positives = 22/40 (55%), Gaps = 3/40 (7%)
Query: 78 GCPTEEGCGE-RFRCFSGQCISKSLVCNGDSDCDEDSADE 116
GC GCGE + C SG C+ +L+C+ DC D DE
Sbjct: 1410 GCAAP-GCGEGQMTCSSGHCLPLALLCDRQDDCG-DGTDE 1447
Score = 32.3 bits (72), Expect = 1.9
Identities = 34/121 (28%), Positives = 39/121 (32%), Gaps = 40/121 (33%)
Query: 454 PCHCRPCQNGGLATVEGTHCLCHCKPYTFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCV 513
PC C NG T G +C +P G + G Q G W WS W PC
Sbjct: 1655 PCPEYTCPNG---TCIGFQLVCDGQP-DCGRPGQVGPSPEEQGCGA---WGPWSPWGPC- 1706
Query: 514 QGKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPS 573
SR C P G GRS C PL L+ + CP
Sbjct: 1707 ------SRTCG---PWGQGRS-----------------------RRCSPLGLLVLQNCPG 1734
Query: 574 P 574
P
Sbjct: 1735 P 1735
Score = 32.0 bits (71), Expect = 2.5
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 91 CFSGQCISKSLVCNGDSDCDEDSADEDRCEDSERRP 126
C SG+C+S C+ DC +D +DED C D P
Sbjct: 2471 CGSGECLSAERRCDLRPDC-QDGSDEDGCVDCVLAP 2505
Score = 31.6 bits (70), Expect = 3.2
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 2/36 (5%)
Query: 85 CGE-RFRCFSGQCISKSLVCNGDSDCDEDSADEDRC 119
CG FRC SG+C + C+ + DC D +DE C
Sbjct: 1565 CGPFEFRCGSGECTPRGWRCDQEEDC-ADGSDERGC 1599
Score = 31.2 bits (69), Expect = 4.2
Identities = 22/61 (36%), Positives = 27/61 (44%), Gaps = 6/61 (9%)
Query: 25 PVNCQWDFYAPWSECNG-CT-KTQTRRRSVAVYGQYGGQPCVGNAFETQSCEP---TRGC 79
PV W +APWS C+ C QTR RS + G C G +T+ C T C
Sbjct: 2828 PVPSIWGLWAPWSTCSAPCDGGIQTRGRSCSSLAP-GDTTCPGPHSQTRDCNTQPCTAQC 2886
Query: 80 P 80
P
Sbjct: 2887 P 2887
Score = 31.2 bits (69), Expect = 4.2
Identities = 19/61 (31%), Positives = 25/61 (40%), Gaps = 3/61 (4%)
Query: 27 NCQWDFYAPWSECN-GCTKTQTRRRSVAVYGQYGGQPC--VGNAFETQSCEPTRGCPTEE 83
NC W +APW C+ C Q RR GG C + A++ + R CP
Sbjct: 3946 NCSWTSWAPWEPCSRSCGVGQQRRLRAYRPPGPGGHWCPNILTAYQERRFCNLRACPVPG 4005
Query: 84 G 84
G
Sbjct: 4006 G 4006
Score = 30.8 bits (68), Expect = 5.5
Identities = 16/37 (43%), Positives = 19/37 (51%), Gaps = 3/37 (8%)
Query: 75 PTRGCPTEEG--CGERFRCFSGQCISKSLVCNGDSDC 109
P G P G C E + C +G CI LVC+G DC
Sbjct: 1644 PALGGPNRTGLPCPE-YTCPNGTCIGFQLVCDGQPDC 1679
Score = 30.8 bits (68), Expect = 5.5
Identities = 26/98 (26%), Positives = 41/98 (41%), Gaps = 17/98 (17%)
Query: 25 PVNCQWDFYAPWSECN---GCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPTRGCPT 81
P +C W ++ WS C+ G Q+R RS + G + + C ++Q C P CP
Sbjct: 4157 PTHCAWSHWSAWSPCSHSCGPRGQQSRFRS-STSGSWAPE-CREEQSQSQPC-PQPSCPP 4213
Query: 82 EEGCGERFR----------CFSGQCISKSLVCNGDSDC 109
G R R C C + ++C D++C
Sbjct: 4214 LCLQGTRSRTLGDSWLQGECQRCSCTPEGVICE-DTEC 4250
Score = 30.0 bits (66), Expect = 9.4
Identities = 24/84 (28%), Positives = 37/84 (44%), Gaps = 12/84 (14%)
Query: 26 VNCQWDFYAPWSECNGCTKTQ----TRRRSVAVYGQYGGQPCVGNAFETQSC--EPTRGC 79
V+C W ++PW++C G +Q + R S G+ C G + + C EP GC
Sbjct: 1908 VDCGWSSWSPWAKCLGPCGSQSIQWSFRSSNNPRPSGRGRQCRGIHRKARRCQTEPCEGC 1967
Query: 80 PTE---EGCGERFR---CFSGQCI 97
+ GER+ C QC+
Sbjct: 1968 EHQGQVHRVGERWHGGPCRVCQCL 1991
>gi|32261332 seizure related 6 homolog (mouse)-like precursor [Homo
sapiens]
Length = 1024
Score = 57.4 bits (137), Expect = 5e-08
Identities = 35/126 (27%), Positives = 53/126 (42%), Gaps = 3/126 (2%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIA 630
C P +++G+ T G + Y C+ GY ++G+ C DL W C+KI
Sbjct: 745 CSDLPEIQNGWKTTSHTELVRGARITYQCDPGYDIVGSDTLTCQWDLSWSSDPPFCEKIM 804
Query: 631 -CVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSP--EMKNAR 687
C P +D P VG + +C+ G LEG S C S +P +
Sbjct: 805 YCTDPGEVDHSTRLISDPVLLVGTTIQYTCNPGFVLEGSSLLTCYSRETGTPIWTSRLPH 864
Query: 688 CVQKEN 693
CV +E+
Sbjct: 865 CVSEES 870
Score = 40.4 bits (93), Expect = 0.007
Identities = 30/100 (30%), Positives = 40/100 (40%), Gaps = 11/100 (11%)
Query: 591 VGKNVVYTCNEGYSLIGNPVARC-----GEDLRWLVGEMHC---QKIACVLPVLMDGIQS 642
VG + YTCN G+ L G+ + C G + W HC + +AC P L +
Sbjct: 826 VGTTIQYTCNPGFVLEGSSLLTCYSRETGTPI-WTSRLPHCVSEESLACDNPGLPENGYQ 884
Query: 643 HPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC--GSSLKWS 680
K Y GE +T C G L G C G W+
Sbjct: 885 ILYKRLYLPGESLTFMCYEGFELMGEVTIRCILGQPSHWN 924
Score = 30.4 bits (67), Expect = 7.2
Identities = 16/64 (25%), Positives = 30/64 (46%), Gaps = 5/64 (7%)
Query: 558 PHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC--GE 615
PHC + C +P ++G+ ++ G+++ + C EG+ L+G RC G+
Sbjct: 863 PHCVSEESLA---CDNPGLPENGYQILYKRLYLPGESLTFMCYEGFELMGEVTIRCILGQ 919
Query: 616 DLRW 619
W
Sbjct: 920 PSHW 923
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
motif, 16 preproprotein [Homo sapiens]
Length = 1224
Score = 57.4 bits (137), Expect = 5e-08
Identities = 37/102 (36%), Positives = 47/102 (46%), Gaps = 12/102 (11%)
Query: 455 CHC--RPCQNGGLATVEGTHCLCHCKPYTFGAACEQGVLVGNQAGG-VDGGWSCWSSWSP 511
CH R C+ + EGT +C + G C V G++ G WS WSSWSP
Sbjct: 543 CHRIGRKCETKFMPAAEGT--ICGHDMWCRGGQC---VKYGDEGPKPTHGHWSDWSSWSP 597
Query: 512 CVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEE 549
C + G RSR C NP PS GG+ C G T C ++
Sbjct: 598 CSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQK 639
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 57.0 bits (136), Expect = 7e-08
Identities = 37/112 (33%), Positives = 50/112 (44%), Gaps = 8/112 (7%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIA 630
C +P + +G + E + +VVY CN G+ LIG V C +D W C ++
Sbjct: 2716 CGTPEPIVNGHINGEN--YSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVS 2773
Query: 631 CVLPVLMDGIQSHPQK--PFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWS 680
C P G H Q YTVG V SC G +L G S +CG W+
Sbjct: 2774 CGHP----GSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWT 2821
Score = 53.5 bits (127), Expect = 8e-07
Identities = 44/144 (30%), Positives = 59/144 (40%), Gaps = 17/144 (11%)
Query: 558 PHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDL 617
P CFP+ FC P G +D G F +V ++C+ L+G+P C D
Sbjct: 3063 PQCFPV------FCGDPGVPSRGRREDRG--FSYRSSVSFSCHPPLVLVGSPRRFCQSDG 3114
Query: 618 RWLVGEMHC---QKIACVLP-VLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLC 673
W + C C P V GIQ++ Q Y VG V C G L+G + C
Sbjct: 3115 TWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQG--YQVGSTVLFRCQKGYLLQGSTTRTC 3172
Query: 674 GSSLKWS---PEMKNARCVQKENP 694
+L WS P+ C Q E P
Sbjct: 3173 LPNLTWSGTPPDCVPHHCRQPETP 3196
Score = 50.8 bits (120), Expect = 5e-06
Identities = 27/95 (28%), Positives = 41/95 (43%), Gaps = 2/95 (2%)
Query: 586 GTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQ 645
GT+ G +++CN GY+L+G+ V C + W E+ C C P + + H
Sbjct: 2671 GTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPI--VNGHIN 2728
Query: 646 KPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWS 680
Y+ V C+ G L G S +C WS
Sbjct: 2729 GENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWS 2763
Score = 49.3 bits (116), Expect = 1e-05
Identities = 65/299 (21%), Positives = 106/299 (35%), Gaps = 46/299 (15%)
Query: 570 FCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLR----WLVGEMH 625
+C P A GF+ + + P G ++ + CN GY L+G+ +A C + W
Sbjct: 2467 YCSLPRAPLHGFILGQTSTQP-GGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIPL 2525
Query: 626 CQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLE--GPSAFLCGSSLKWSPEM 683
CQ ++C LP ++ YTVG K SCS G L+ + C + WS
Sbjct: 2526 CQALSCGLPEAPKNGMVFGKE--YTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRN 2583
Query: 684 KNARCVQKENPLTQAVP-KCQRWEKLQNS------------------------RCVCKMP 718
+CV P ++ + RW + + RC
Sbjct: 2584 VPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGK 2643
Query: 719 YECGPSLDVCAQDERSKRILPLTVCKMHVLHCQGRNYTLTGRDSCTLPASAEKACGACPL 778
+ G S C + +P ++ L G + TL S + C A L
Sbjct: 2644 WSLGDSTPTCRIISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGL 2703
Query: 779 WGKCDAESSKCVCREASECEEEGFSICVEVNGKE-----QTMSECEAGALRCRGQSISV 832
W + +C+ A C + +NG+ + +C AG R G S+ +
Sbjct: 2704 WSGSEV---RCL---AGHCGTPEPIVNGHINGENYSYRGSVVYQCNAG-FRLIGMSVRI 2755
Score = 43.5 bits (101), Expect = 8e-04
Identities = 34/119 (28%), Positives = 46/119 (38%), Gaps = 9/119 (7%)
Query: 583 QDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIA---CVLPVLMDG 639
Q G + VG V Y+C +L+GN CG D W HC + C P G
Sbjct: 2784 QMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDP----G 2839
Query: 640 IQSHPQK--PFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLT 696
I +H + + G + SC G L G S C ++ WS + NP T
Sbjct: 2840 IPAHGIRLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGT 2898
Score = 40.8 bits (94), Expect = 0.005
Identities = 23/66 (34%), Positives = 33/66 (50%), Gaps = 7/66 (10%)
Query: 556 LEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC-- 613
L+P C L + CP P +G V+ G + VG++V + C GY L G+PV C
Sbjct: 2111 LDPGCEAYEL---QECPDPEPFANGIVRGAG--YNVGQSVTFECLPGYQLTGHPVLTCQH 2165
Query: 614 GEDLRW 619
G + W
Sbjct: 2166 GTNRNW 2171
Score = 40.8 bits (94), Expect = 0.005
Identities = 27/100 (27%), Positives = 42/100 (42%), Gaps = 4/100 (4%)
Query: 586 GTMFPVGKNVVYTCNEGYSLIGNPVA--RCGEDLRWLVGEMHCQKIACVLPVLMDGIQSH 643
G F K V Y C GY + + V+ C +D W + C+ + C P L+ +
Sbjct: 2965 GNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVV 3024
Query: 644 PQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEM 683
+ G VT +C G L P+ F C + W+ E+
Sbjct: 3025 GSD--FMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGEL 3062
Score = 40.0 bits (92), Expect = 0.009
Identities = 38/159 (23%), Positives = 61/159 (38%), Gaps = 33/159 (20%)
Query: 562 PLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLV 621
P + PT + P + +Q+ + VG V++ C +GY L G+ C +L W
Sbjct: 3121 PSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSG 3180
Query: 622 GEMHCQKIACVLPVLMDGIQSHPQKPFY---------TVGEKVTVSCSGGMSLEGPSAF- 671
C C P+ P + ++G + SC G SL+G S
Sbjct: 3181 TPPDCVPHHC----------RQPETPTHANVGALDLPSMGYTLIYSCQEGFSLKGGSEHR 3230
Query: 672 LCGSSLKWSPEMKNARCVQ-----------KENPLTQAV 699
C + W+ K C++ +E PLTQA+
Sbjct: 3231 TCKADGSWTG--KPPICLEVRPSGRPINTAREPPLTQAL 3267
Score = 39.3 bits (90), Expect = 0.015
Identities = 32/112 (28%), Positives = 45/112 (40%), Gaps = 8/112 (7%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIA 630
C PP + +G V G+ F G +V Y C EGY L V C + W C +
Sbjct: 3012 CKPPPLIPNGKVV--GSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVF 3069
Query: 631 CVLPVLMDGIQSHPQKP--FYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWS 680
C P G+ S ++ ++ V+ SC + L G C S WS
Sbjct: 3070 CGDP----GVPSRGRREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDGTWS 3117
Score = 38.1 bits (87), Expect = 0.034
Identities = 18/50 (36%), Positives = 24/50 (48%)
Query: 564 SLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC 613
S P CP P L + V E F +G V Y C G++L+GN + C
Sbjct: 2287 SAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTC 2336
Score = 33.5 bits (75), Expect = 0.85
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC 613
CP P + G + G+ F +G +V +TCNEGY L G+ C
Sbjct: 343 CPDPGIPERG--KRLGSDFRLGSSVQFTCNEGYDLQGSKRITC 383
Score = 32.0 bits (71), Expect = 2.5
Identities = 21/60 (35%), Positives = 28/60 (46%), Gaps = 6/60 (10%)
Query: 571 CPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC----GEDLRWLVGEMHC 626
C S P + G + G+ F VG V + CN GY+L G+P C G +W V C
Sbjct: 1735 CSSVPEPRYG--KRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTC 1792
Score = 31.2 bits (69), Expect = 4.2
Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 5/52 (9%)
Query: 571 CPSPPALKDGF-VQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC--GEDLRW 619
C P K G+ V DEG G +V ++C+ GYSL G+ C GE W
Sbjct: 1211 CEDPGTPKFGYKVHDEGHF--AGSSVSFSCDPGYSLRGSEELLCLSGERRTW 1260
Score = 30.4 bits (67), Expect = 7.2
Identities = 15/47 (31%), Positives = 23/47 (48%), Gaps = 2/47 (4%)
Query: 567 PTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARC 613
P E C P ++K+G G+ +G +V Y C+ GY + G C
Sbjct: 1554 PRESCFDPGSIKNG--TRVGSDLKLGSSVTYYCHGGYEVEGTSTLSC 1598
Score = 30.4 bits (67), Expect = 7.2
Identities = 25/102 (24%), Positives = 39/102 (38%), Gaps = 8/102 (7%)
Query: 582 VQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLP-VLMDGI 640
V +G +F ++VY C EGY G C + W + C I C P + +G+
Sbjct: 2905 VFSDGLVF--SSSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGL 2962
Query: 641 QSHPQKPFYTVGEKVTVSCSGGMSLEG--PSAFLCGSSLKWS 680
+ + + VT C G +E S C W+
Sbjct: 2963 RLGND---FRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWN 3001
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 57.0 bits (136), Expect = 7e-08
Identities = 24/53 (45%), Positives = 31/53 (58%), Gaps = 4/53 (7%)
Query: 499 VDGGWSCWSSWSPCVQ----GKKTRSRECNNPPPSGGGRSCVGETTESTQCED 547
VDG WS W +WS C + G + R R+C+NPPP GG C G + E CE+
Sbjct: 542 VDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCEN 594
>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
Length = 449
Score = 56.6 bits (135), Expect = 9e-08
Identities = 67/260 (25%), Positives = 91/260 (35%), Gaps = 49/260 (18%)
Query: 505 CWSSWSPCVQGKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFP-- 562
C W+ CV + +CN PP G ++ T E + + C P
Sbjct: 9 CLMLWAICV------AEDCNELPPRRNTEILTGSWSDQTYPEGTQAIY------KCRPGY 56
Query: 563 ---------------LSLVPTEFCPSPPALKDG------FVQDEGTMFPVGKNVVYTCNE 601
++L P C P G F G +F G VYTCNE
Sbjct: 57 RSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNE 116
Query: 602 GYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLM---DGIQSHPQKP--FYTVGEKVT 656
GY L+G R + W C+ + C LPV I S +P Y G+ V
Sbjct: 117 GYQLLGEINYRECDTDGWTNDIPICEVVKC-LPVTAPENGKIVSSAMEPDREYHFGQAVR 175
Query: 657 VSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQ---KENPLTQAVPKCQRWEKLQNSR- 712
C+ G +EG C WS E +CV+ K + P Q+ +N R
Sbjct: 176 FVCNSGYKIEGDEEMHCSDDGFWSKE--KPKCVEISCKSPDVINGSPISQKIIYKENERF 233
Query: 713 -CVCKMPYECGPSLD-VCAQ 730
C M YE D VC +
Sbjct: 234 QYKCNMGYEYSERGDAVCTE 253
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/90 (27%), Positives = 39/90 (43%), Gaps = 2/90 (2%)
Query: 592 GKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTV 651
G+ V + CN GY + G+ C +D W + C +I+C P +++G QK Y
Sbjct: 171 GQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVING-SPISQKIIYKE 229
Query: 652 GEKVTVSCSGGMSLEGPSAFLCGSSLKWSP 681
E+ C+ G +C S W P
Sbjct: 230 NERFQYKCNMGYEYSERGDAVCTES-GWRP 258
Score = 30.4 bits (67), Expect = 7.2
Identities = 12/31 (38%), Positives = 20/31 (64%)
Query: 575 PALKDGFVQDEGTMFPVGKNVVYTCNEGYSL 605
P L++G+ Q+ G F GK++ C+ GY+L
Sbjct: 392 PYLENGYNQNHGRKFVQGKSIDVACHPGYAL 422
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,789,818
Number of Sequences: 37866
Number of extensions: 1978678
Number of successful extensions: 7542
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 167
Number of HSP's successfully gapped in prelim test: 83
Number of HSP's that attempted gapping in prelim test: 5683
Number of HSP's gapped (non-prelim): 1482
length of query: 843
length of database: 18,247,518
effective HSP length: 111
effective length of query: 732
effective length of database: 14,044,392
effective search space: 10280494944
effective search space used: 10280494944
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.